Search of human proteins with 148596974

Search of human proteins with 148596974

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|148596974 TXK tyrosine kinase [Homo sapiens]
         (527 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|148596974 TXK tyrosine kinase [Homo sapiens]                      1089   0.0  
gi|130977759 tec protein tyrosine kinase [Homo sapiens]               614   e-176
gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]   571   e-163
gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]                561   e-160
gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens]            470   e-132
gi|42544182 BMX non-receptor tyrosine kinase [Homo sapiens]           470   e-132
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a...   333   2e-91
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b...   333   2e-91
gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog is...   333   2e-91
gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]      332   4e-91
gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]       332   4e-91
gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog ...   331   1e-90
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap...   328   6e-90
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi...   328   6e-90
gi|112789548 lymphocyte-specific protein tyrosine kinase precurs...   328   1e-89
gi|112789546 lymphocyte-specific protein tyrosine kinase precurs...   328   1e-89
gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]     327   2e-89
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]             322   4e-88
gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]                 322   5e-88
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]             322   5e-88
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]               322   5e-88
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]             322   5e-88
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]             322   5e-88
gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo sa...   320   2e-87
gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo sa...   320   2e-87
gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo sapi...   320   2e-87
gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]              317   2e-86
gi|4503787 fyn-related kinase [Homo sapiens]                          315   6e-86
gi|187475373 c-src tyrosine kinase [Homo sapiens]                     285   7e-77
gi|4758078 c-src tyrosine kinase [Homo sapiens]                       285   7e-77

>gi|148596974 TXK tyrosine kinase [Homo sapiens]
          Length = 527

 Score = 1089 bits (2817), Expect = 0.0
 Identities = 527/527 (100%), Positives = 527/527 (100%)

Query: 1   MILSSYNTIQSVFCCCCCCSVQKRQMRTQISLSTDEELPEKYTQRRRPWLSQLSNKKQSN 60
           MILSSYNTIQSVFCCCCCCSVQKRQMRTQISLSTDEELPEKYTQRRRPWLSQLSNKKQSN
Sbjct: 1   MILSSYNTIQSVFCCCCCCSVQKRQMRTQISLSTDEELPEKYTQRRRPWLSQLSNKKQSN 60

Query: 61  TGRVQPSKRKPLPPLPPSEVAEEKIQVKALYDFLPREPCNLALRRAEEYLILEKYNPHWW 120
           TGRVQPSKRKPLPPLPPSEVAEEKIQVKALYDFLPREPCNLALRRAEEYLILEKYNPHWW
Sbjct: 61  TGRVQPSKRKPLPPLPPSEVAEEKIQVKALYDFLPREPCNLALRRAEEYLILEKYNPHWW 120

Query: 121 KARDRLGNEGLIPSNYVTENKITNLEIYEWYHRNITRNQAEHLLRQESKEGAFIVRDSRH 180
           KARDRLGNEGLIPSNYVTENKITNLEIYEWYHRNITRNQAEHLLRQESKEGAFIVRDSRH
Sbjct: 121 KARDRLGNEGLIPSNYVTENKITNLEIYEWYHRNITRNQAEHLLRQESKEGAFIVRDSRH 180

Query: 181 LGSYTISVFMGARRSTEAAIKHYQIKKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMT 240
           LGSYTISVFMGARRSTEAAIKHYQIKKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMT
Sbjct: 181 LGSYTISVFMGARRSTEAAIKHYQIKKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMT 240

Query: 241 RLRYPVGLMGSCLPATAGFSYEKWEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKA 300
           RLRYPVGLMGSCLPATAGFSYEKWEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKA
Sbjct: 241 RLRYPVGLMGSCLPATAGFSYEKWEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKA 300

Query: 301 INEGSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKG 360
           INEGSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKG
Sbjct: 301 INEGSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKG 360

Query: 361 KLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEY 420
           KLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEY
Sbjct: 361 KLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEY 420

Query: 421 VSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAIS 480
           VSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAIS
Sbjct: 421 VSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAIS 480

Query: 481 EGFRLYRPHLAPMSIYEVMYSCWHEKPEGRPTFAELLRAVTEIAETW 527
           EGFRLYRPHLAPMSIYEVMYSCWHEKPEGRPTFAELLRAVTEIAETW
Sbjct: 481 EGFRLYRPHLAPMSIYEVMYSCWHEKPEGRPTFAELLRAVTEIAETW 527


>gi|130977759 tec protein tyrosine kinase [Homo sapiens]
          Length = 631

 Score =  614 bits (1584), Expect = e-176
 Identities = 290/463 (62%), Positives = 359/463 (77%), Gaps = 2/463 (0%)

Query: 65  QPSKRKPLPPLPPSEVAEEKIQVKALYDFLPREPCNLALRRAEEYLILEKYNPHWWKARD 124
           +  KR+P PP+P  E    +  V A+YDF   E  +L L R +EYLILEK + HWW+ARD
Sbjct: 162 ETKKRRPPPPIPLEEEDNSEEIVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARD 221

Query: 125 RLGNEGLIPSNYVTENKITNLEIYEWYHRNITRNQAEHLLRQESKEGAFIVRDSRHLGSY 184
           + GNEG IPSNYVT  K  NL+ YEWY RN+ R++AE LLR E KEG F+VRDS   G Y
Sbjct: 222 KYGNEGYIPSNYVTGKKSNNLDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDSSQPGLY 281

Query: 185 TISVFMGARRSTEAAIKHYQIKKNDSG--QWYVAERHAFQSIPELIWYHQHNAAGLMTRL 242
           T+S++        +  +HY IK+  +   ++Y+AE+HAF SIPE+I YH+HNAAGL+TRL
Sbjct: 282 TVSLYTKFGGEGSSGFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRL 341

Query: 243 RYPVGLMGSCLPATAGFSYEKWEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAIN 302
           RYPV + G   P TAGFSYEKWEI+PSEL F++E+GSG FGVV LG+WR+  +VAIKAI 
Sbjct: 342 RYPVSVKGKNAPTTAGFSYEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIR 401

Query: 303 EGSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKGKL 362
           EG+M EEDFIEEAKVMMKL+H KLVQLYGVC Q+KP+YIVTEFME GCLLN+LR+ +G  
Sbjct: 402 EGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHF 461

Query: 363 RKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVS 422
            +++LLS+CQD+CEGMEYLERN +IHRDLAARNCLVS   +VK+SDFGM RYVLDD+Y S
Sbjct: 462 SRDVLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTS 521

Query: 423 SFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEG 482
           S GAKFP+KW PPEVF ++++SSKSDVWSFGVLMWEVFTEG+MPFE  +N +VV  ++ G
Sbjct: 522 SSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRG 581

Query: 483 FRLYRPHLAPMSIYEVMYSCWHEKPEGRPTFAELLRAVTEIAE 525
            RLY+P LA   +YEVM  CW EKPEGRP+F +LLR + E+ E
Sbjct: 582 HRLYQPKLASNYVYEVMLRCWQEKPEGRPSFEDLLRTIDELVE 624


>gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]
          Length = 659

 Score =  571 bits (1472), Expect = e-163
 Identities = 271/512 (52%), Positives = 362/512 (70%), Gaps = 12/512 (2%)

Query: 17  CCCSVQKRQMRTQISLSTDEELPEKYTQRRRPWLSQLSNKKQSNTGRVQPSKRKPLPPLP 76
           CC    K  M  QI  + +  L    + R+       + K    T       +KPLPP P
Sbjct: 154 CCSQTAKNAMGCQILENRNGSLKPGSSHRK-------TKKPLPPTPEEDQILKKPLPPEP 206

Query: 77  ---PSEVAEEKIQVKALYDFLPREPCNLALRRAEEYLILEKYNPHWWKARDRLGNEGLIP 133
              P   +E K +V ALYD++P    +L LR+ +EY ILE+ N  WW+ARD+ G EG IP
Sbjct: 207 AAAPVSTSELK-KVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIP 265

Query: 134 SNYVTENKITNLEIYEWYHRNITRNQAEHLLRQESKEGAFIVRDSRHLGSYTISVFMGAR 193
           SNYVTE +  ++E+YEWY +++TR+QAE LL+QE KEG FIVRDS   G YT+SVF  + 
Sbjct: 266 SNYVTEAE-DSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKST 324

Query: 194 RSTEAAIKHYQIKKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCL 253
              +  I+HY +      Q+Y+AE+H F +IPELI YHQHN+AGL++RL+YPV       
Sbjct: 325 GDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNA 384

Query: 254 PATAGFSYEKWEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIE 313
           P+TAG  Y  WEIDP +L F+KE+G+GQFGVV  G+WR    VAIK I EGSMSE++FIE
Sbjct: 385 PSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIE 444

Query: 314 EAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKGKLRKEMLLSVCQD 373
           EAKVMM LSH KLVQLYGVC +++P++I+TE+M NGCLLNYLRE + + + + LL +C+D
Sbjct: 445 EAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKD 504

Query: 374 ICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWS 433
           +CE MEYLE   ++HRDLAARNCLV+   +VK+SDFG++RYVLDDEY SS G+KFP++WS
Sbjct: 505 VCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWS 564

Query: 434 PPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPM 493
           PPEV +++K+SSKSD+W+FGVLMWE+++ GKMP+E  +N +  E I++G RLYRPHLA  
Sbjct: 565 PPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASE 624

Query: 494 SIYEVMYSCWHEKPEGRPTFAELLRAVTEIAE 525
            +Y +MYSCWHEK + RPTF  LL  + ++ +
Sbjct: 625 KVYTIMYSCWHEKADERPTFKILLSNILDVMD 656


>gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]
          Length = 620

 Score =  561 bits (1446), Expect = e-160
 Identities = 281/487 (57%), Positives = 352/487 (72%), Gaps = 13/487 (2%)

Query: 51  SQLSNKKQSNTGRVQPSK---RKPLPPLP-----PSEVAEEKIQVKALYDFLPREPCNLA 102
           SQL  K  +   +  P+K   +KPLPP P     P    EE + + ALYD+   +P  LA
Sbjct: 134 SQLE-KLATGCAQYDPTKNASKKPLPPTPEDNRRPLWEPEETVVI-ALYDYQTNDPQELA 191

Query: 103 LRRAEEYLILEKYNPHWWKARDRLGNEGLIPSNYVTENKITNLEIYEWYHRNITRNQAEH 162
           LRR EEY +L+    HWW+ +DR G+EG +PS+Y+ E    NLE YEWY+++I+R++AE 
Sbjct: 192 LRRNEEYCLLDSSEIHWWRVQDRNGHEGYVPSSYLVEKSPNNLETYEWYNKSISRDKAEK 251

Query: 163 LLRQESKEGAFIVRDSRHLGSYTISVFMGARRS-TEAAIKHYQIKKNDSG--QWYVAERH 219
           LL    KEGAF+VRDSR  G+YT+SVF  A  S     IKHY IK+ +    ++YVAE++
Sbjct: 252 LLLDTGKEGAFMVRDSRTAGTYTVSVFTKAVVSENNPCIKHYHIKETNDNPKRYYVAEKY 311

Query: 220 AFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAGFSYEKWEIDPSELAFIKEIGS 279
            F SIP LI YHQHN  GL+TRLRYPV       P TAG  Y KW IDPSEL F++EIGS
Sbjct: 312 VFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDPSELTFVQEIGS 371

Query: 280 GQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRKPL 339
           GQFG+VHLG W +  +VAIK I EG+MSEEDFIEEA+VMMKLSH KLVQLYGVC+++ P+
Sbjct: 372 GQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPI 431

Query: 340 YIVTEFMENGCLLNYLRENKGKLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVS 399
            +V EFME+GCL +YLR  +G    E LL +C D+CEGM YLE    IHRDLAARNCLV 
Sbjct: 432 CLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVG 491

Query: 400 STCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEV 459
              ++K+SDFGMTR+VLDD+Y SS G KFP+KW+ PEVF F++YSSKSDVWSFGVLMWEV
Sbjct: 492 ENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEV 551

Query: 460 FTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCWHEKPEGRPTFAELLRA 519
           F+EGK+P+EN+SN +VVE IS GFRLY+P LA   +Y++M  CW E+PE RP F+ LLR 
Sbjct: 552 FSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFSRLLRQ 611

Query: 520 VTEIAET 526
           + EIAE+
Sbjct: 612 LAEIAES 618


>gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens]
          Length = 675

 Score =  470 bits (1209), Expect = e-132
 Identities = 238/498 (47%), Positives = 318/498 (63%), Gaps = 39/498 (7%)

Query: 50  LSQLSNKKQSNTGRVQPSKRKPLPPLPPSEVAEEKIQVKALYDFLPREPCNLALRRAEEY 109
           L+Q  N+ + N G          PP   + +A+     K +Y   P    N+     E++
Sbjct: 191 LAQYDNESKKNYGSQ--------PPSSSTSLAQYDSNSKKIYGSQPN--FNMQYIPREDF 240

Query: 110 LILEKYNPHWWKAR---DRLGNEGLIPSNYVTEN------KIT-------------NLEI 147
                  P WW+ R       +E +  SN    N      KI+             NL+ 
Sbjct: 241 -------PDWWQVRKLKSSSSSEDVASSNQKERNVNHTTSKISWEFPESSSSEEEENLDD 293

Query: 148 YEWYHRNITRNQAEHLLRQESKEGAFIVRDSRHLGSYTISVFMGARRSTEAAIKHYQIKK 207
           Y+W+  NI+R+Q+E LLRQ+ KEGAF+VR+S  +G YT+S+F  A    +  +KHY +  
Sbjct: 294 YDWFAGNISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVSLFSKAVNDKKGTVKHYHVHT 353

Query: 208 NDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAGFSYEKWEID 267
           N   + Y+AE + F SIP+LI YHQHN+AG++TRLR+PV    + +P +       WE+ 
Sbjct: 354 NAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNGIWELK 413

Query: 268 PSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSHSKLV 327
             E+  +KE+GSGQFGVV LG+W+    VA+K I EGSMSE++F +EA+ MMKLSH KLV
Sbjct: 414 REEITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLV 473

Query: 328 QLYGVCIQRKPLYIVTEFMENGCLLNYLRENKGKLRKEMLLSVCQDICEGMEYLERNGYI 387
           + YGVC +  P+YIVTE++ NGCLLNYLR +   L    LL +C D+CEGM +LE + +I
Sbjct: 474 KFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFI 533

Query: 388 HRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNKYSSKS 447
           HRDLAARNCLV     VK+SDFGMTRYVLDD+YVSS G KFP+KWS PEVF + KYSSKS
Sbjct: 534 HRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKS 593

Query: 448 DVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCWHEKP 507
           DVW+FG+LMWEVF+ GK P++   N QVV  +S+G RLYRPHLA  +IY++MYSCWHE P
Sbjct: 594 DVWAFGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELP 653

Query: 508 EGRPTFAELLRAVTEIAE 525
           E RPTF +LL ++  + E
Sbjct: 654 EKRPTFQQLLSSIEPLRE 671


>gi|42544182 BMX non-receptor tyrosine kinase [Homo sapiens]
          Length = 675

 Score =  470 bits (1209), Expect = e-132
 Identities = 238/498 (47%), Positives = 318/498 (63%), Gaps = 39/498 (7%)

Query: 50  LSQLSNKKQSNTGRVQPSKRKPLPPLPPSEVAEEKIQVKALYDFLPREPCNLALRRAEEY 109
           L+Q  N+ + N G          PP   + +A+     K +Y   P    N+     E++
Sbjct: 191 LAQYDNESKKNYGSQ--------PPSSSTSLAQYDSNSKKIYGSQPN--FNMQYIPREDF 240

Query: 110 LILEKYNPHWWKAR---DRLGNEGLIPSNYVTEN------KIT-------------NLEI 147
                  P WW+ R       +E +  SN    N      KI+             NL+ 
Sbjct: 241 -------PDWWQVRKLKSSSSSEDVASSNQKERNVNHTTSKISWEFPESSSSEEEENLDD 293

Query: 148 YEWYHRNITRNQAEHLLRQESKEGAFIVRDSRHLGSYTISVFMGARRSTEAAIKHYQIKK 207
           Y+W+  NI+R+Q+E LLRQ+ KEGAF+VR+S  +G YT+S+F  A    +  +KHY +  
Sbjct: 294 YDWFAGNISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVSLFSKAVNDKKGTVKHYHVHT 353

Query: 208 NDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAGFSYEKWEID 267
           N   + Y+AE + F SIP+LI YHQHN+AG++TRLR+PV    + +P +       WE+ 
Sbjct: 354 NAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNGIWELK 413

Query: 268 PSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSHSKLV 327
             E+  +KE+GSGQFGVV LG+W+    VA+K I EGSMSE++F +EA+ MMKLSH KLV
Sbjct: 414 REEITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLV 473

Query: 328 QLYGVCIQRKPLYIVTEFMENGCLLNYLRENKGKLRKEMLLSVCQDICEGMEYLERNGYI 387
           + YGVC +  P+YIVTE++ NGCLLNYLR +   L    LL +C D+CEGM +LE + +I
Sbjct: 474 KFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFI 533

Query: 388 HRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNKYSSKS 447
           HRDLAARNCLV     VK+SDFGMTRYVLDD+YVSS G KFP+KWS PEVF + KYSSKS
Sbjct: 534 HRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKS 593

Query: 448 DVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCWHEKP 507
           DVW+FG+LMWEVF+ GK P++   N QVV  +S+G RLYRPHLA  +IY++MYSCWHE P
Sbjct: 594 DVWAFGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELP 653

Query: 508 EGRPTFAELLRAVTEIAE 525
           E RPTF +LL ++  + E
Sbjct: 654 EKRPTFQQLLSSIEPLRE 671


>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
           [Homo sapiens]
          Length = 1130

 Score =  333 bits (854), Expect = 2e-91
 Identities = 177/437 (40%), Positives = 265/437 (60%), Gaps = 18/437 (4%)

Query: 89  ALYDFLPREPCNLALRRAEEYLILE-KYNPHWWKARDRLGNEGLIPSNYVTENKITNLEI 147
           ALYDF+      L++ + E+  +L   +N  W +A+ + G +G +PSNY+T   + +LE 
Sbjct: 68  ALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNG-QGWVPSNYITP--VNSLEK 124

Query: 148 YEWYHRNITRNQAEHLLRQESKEGAFIVRDSRHL-GSYTISVFMGARRSTEAAIKHYQIK 206
           + WYH  ++RN AE+LL      G+F+VR+S    G  +IS+        E  + HY+I 
Sbjct: 125 HSWYHGPVSRNAAEYLL-SSGINGSFLVRESESSPGQRSISL------RYEGRVYHYRIN 177

Query: 207 KNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAGFS--YEKW 264
               G+ YV+    F ++ EL+ +H   A GL+T L YP        P   G S  Y+KW
Sbjct: 178 TASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNK--PTVYGVSPNYDKW 235

Query: 265 EIDPSELAFIKEIGSGQFGVVHLGEWRSH-IQVAIKAINEGSMSEEDFIEEAKVMMKLSH 323
           E++ +++    ++G GQ+G V+ G W+ + + VA+K + E +M  E+F++EA VM ++ H
Sbjct: 236 EMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 295

Query: 324 SKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRE-NKGKLRKEMLLSVCQDICEGMEYLE 382
             LVQL GVC +  P YI+TEFM  G LL+YLRE N+ ++   +LL +   I   MEYLE
Sbjct: 296 PNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLE 355

Query: 383 RNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNK 442
           +  +IHRDLAARNCLV    +VK++DFG++R +  D Y +  GAKFPIKW+ PE   +NK
Sbjct: 356 KKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNK 415

Query: 443 YSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSC 502
           +S KSDVW+FGVL+WE+ T G  P+      QV E + + +R+ RP   P  +YE+M +C
Sbjct: 416 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRAC 475

Query: 503 WHEKPEGRPTFAELLRA 519
           W   P  RP+FAE+ +A
Sbjct: 476 WQWNPSDRPSFAEIHQA 492


>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
           [Homo sapiens]
          Length = 1149

 Score =  333 bits (854), Expect = 2e-91
 Identities = 177/437 (40%), Positives = 265/437 (60%), Gaps = 18/437 (4%)

Query: 89  ALYDFLPREPCNLALRRAEEYLILE-KYNPHWWKARDRLGNEGLIPSNYVTENKITNLEI 147
           ALYDF+      L++ + E+  +L   +N  W +A+ + G +G +PSNY+T   + +LE 
Sbjct: 87  ALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNG-QGWVPSNYITP--VNSLEK 143

Query: 148 YEWYHRNITRNQAEHLLRQESKEGAFIVRDSRHL-GSYTISVFMGARRSTEAAIKHYQIK 206
           + WYH  ++RN AE+LL      G+F+VR+S    G  +IS+        E  + HY+I 
Sbjct: 144 HSWYHGPVSRNAAEYLL-SSGINGSFLVRESESSPGQRSISL------RYEGRVYHYRIN 196

Query: 207 KNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAGFS--YEKW 264
               G+ YV+    F ++ EL+ +H   A GL+T L YP        P   G S  Y+KW
Sbjct: 197 TASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNK--PTVYGVSPNYDKW 254

Query: 265 EIDPSELAFIKEIGSGQFGVVHLGEWRSH-IQVAIKAINEGSMSEEDFIEEAKVMMKLSH 323
           E++ +++    ++G GQ+G V+ G W+ + + VA+K + E +M  E+F++EA VM ++ H
Sbjct: 255 EMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 314

Query: 324 SKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRE-NKGKLRKEMLLSVCQDICEGMEYLE 382
             LVQL GVC +  P YI+TEFM  G LL+YLRE N+ ++   +LL +   I   MEYLE
Sbjct: 315 PNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLE 374

Query: 383 RNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNK 442
           +  +IHRDLAARNCLV    +VK++DFG++R +  D Y +  GAKFPIKW+ PE   +NK
Sbjct: 375 KKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNK 434

Query: 443 YSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSC 502
           +S KSDVW+FGVL+WE+ T G  P+      QV E + + +R+ RP   P  +YE+M +C
Sbjct: 435 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRAC 494

Query: 503 WHEKPEGRPTFAELLRA 519
           W   P  RP+FAE+ +A
Sbjct: 495 WQWNPSDRPSFAEIHQA 511


>gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
           isoform A [Homo sapiens]
          Length = 512

 Score =  333 bits (854), Expect = 2e-91
 Identities = 185/469 (39%), Positives = 281/469 (59%), Gaps = 35/469 (7%)

Query: 66  PSKRKPLPPLPPSEVAE-EKIQVK----------ALYDFLPREPCNLALRRAEEYLILEK 114
           P+  K   P+P S++   ++ Q K          ALY +    P +L+ ++ E+  +LE+
Sbjct: 36  PTSNKQQRPVPESQLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEE 95

Query: 115 YNPHWWKARDRLGN-EGLIPSNYVTENKITNLEIYEWYHRNITRNQAEH-LLRQESKEGA 172
           +   WWKA+  L   EG IPSNYV   K+  LE  EW+ ++ITR  AE  LL   +  GA
Sbjct: 96  HG-EWWKAKSLLTKKEGFIPSNYVA--KLNTLETEEWFFKDITRKDAERQLLAPGNSAGA 152

Query: 173 FIVRDSRHL-GSYTISVFMGARRSTEAA----IKHYQIKKNDSGQWYVAERHAFQSIPEL 227
           F++R+S  L GS+++SV     R  +      IKHY+I+  D+G +Y++ R  F  I ++
Sbjct: 153 FLIRESETLKGSFSLSV-----RDFDPVHGDVIKHYKIRSLDNGGYYISPRITFPCISDM 207

Query: 228 IWYHQHNAAGLMTRLRYPVGLMGSCLPATAGFSYEK--WEIDPSELAFIKEIGSGQFGVV 285
           I ++Q  A GL  RL        +C+       ++K  WEI    +  +K +G+GQFG V
Sbjct: 208 IKHYQKQADGLCRRLEK------ACISPKPQKPWDKDAWEIPRESIKLVKRLGAGQFGEV 261

Query: 286 HLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEF 345
            +G + +  +VA+K +  G+MS + F+EEA +M  L H KLV+LY V  + +P+YI+TE+
Sbjct: 262 WMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEY 321

Query: 346 MENGCLLNYLRENKG-KLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIV 404
           M  G LL++L+ ++G K+    L+     I EGM Y+ER  YIHRDL A N LVS + + 
Sbjct: 322 MAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMC 381

Query: 405 KISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGK 464
           KI+DFG+ R + D+EY +  GAKFPIKW+ PE   F  ++ KSDVWSFG+L++E+ T GK
Sbjct: 382 KIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGK 441

Query: 465 MPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCWHEKPEGRPTF 513
           +P+  ++N  V+ A+S+G+R+ R    P  +Y++M  CW EK E RPTF
Sbjct: 442 IPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTF 490


>gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]
          Length = 534

 Score =  332 bits (852), Expect = 4e-91
 Identities = 171/432 (39%), Positives = 264/432 (61%), Gaps = 11/432 (2%)

Query: 89  ALYDFLPREPCNLALRRAEEYLILEKYNPHWWKARD-RLGNEGLIPSNYVTENKITNLEI 147
           ALYD+  R   +L+  + E++ IL      WW+AR    G  G IPSNYV    + +++ 
Sbjct: 89  ALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAP--VDSIQA 146

Query: 148 YEWYHRNITRNQAEH-LLRQESKEGAFIVRDSRHL-GSYTISVFMGARRSTEAAIKHYQI 205
            EWY   + R  AE  LL   +  G F++R+S    G+Y++S+        +  +KHY+I
Sbjct: 147 EEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDH-VKHYKI 205

Query: 206 KKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAGFSYEKWE 265
           +K D+G +Y+  R  F+++ +L+ ++   A GL   L     +  SC P T+G + + WE
Sbjct: 206 RKLDNGGYYITTRAQFETLQQLVQHYSEKADGLCFNLTV---IASSCTPQTSGLAKDAWE 262

Query: 266 IDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSHSK 325
           +    L   K++G G F  V LG W  + +VAIK +  G+MS E F+EEA++M KL H K
Sbjct: 263 VARRSLCLEKKLGQGCFAEVWLGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDK 322

Query: 326 LVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKGK-LRKEMLLSVCQDICEGMEYLERN 384
           LVQLY V +  +P+YIVTE+M  G LL++L++ +G+ L+   L+ +   +  GM Y+ER 
Sbjct: 323 LVQLYAV-VSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERM 381

Query: 385 GYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNKYS 444
            YIHRDL + N LV +  I KI+DFG+ R + D+EY +  GAKFPIKW+ PE  L+ +++
Sbjct: 382 NYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFT 441

Query: 445 SKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCWH 504
            KSDVWSFG+L+ E+ T+G++P+   +N +V+E +  G+R+  P   P+S++E+M  CW 
Sbjct: 442 IKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWK 501

Query: 505 EKPEGRPTFAEL 516
           + PE RPTF  L
Sbjct: 502 KDPEERPTFEYL 513


>gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]
          Length = 537

 Score =  332 bits (852), Expect = 4e-91
 Identities = 173/432 (40%), Positives = 265/432 (61%), Gaps = 8/432 (1%)

Query: 89  ALYDFLPREPCNLALRRAEEYLILEKYNPHWWKARD-RLGNEGLIPSNYVTENKITNLEI 147
           ALYD+  R   +L+  + E++ IL      WW+AR    G  G IPSNYV    + +++ 
Sbjct: 89  ALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAP--VDSIQA 146

Query: 148 YEWYHRNITRNQAEH-LLRQESKEGAFIVRDSRHL-GSYTISVFMGARRSTEAAIKHYQI 205
            EWY   + R  AE  LL   +  G F++R+S    G+Y++S+        +  +KHY+I
Sbjct: 147 EEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDH-VKHYKI 205

Query: 206 KKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAGFSYEKWE 265
           +K D+G +Y+  R  F+++ +L+ ++   AAGL  RL  P       L   +  + + WE
Sbjct: 206 RKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWE 265

Query: 266 IDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSHSK 325
           I    L  IK +G+GQFG V +G W  + +VAIK +  G+MS E F+EEA++M KL H K
Sbjct: 266 IPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDK 325

Query: 326 LVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKGK-LRKEMLLSVCQDICEGMEYLERN 384
           LVQLY V +  +P+YIVTE+M  G LL++L++ +G+ L+   L+ +   +  GM Y+ER 
Sbjct: 326 LVQLYAV-VSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERM 384

Query: 385 GYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNKYS 444
            YIHRDL + N LV +  I KI+DFG+ R + D+EY +  GAKFPIKW+ PE  L+ +++
Sbjct: 385 NYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFT 444

Query: 445 SKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCWH 504
            KSDVWSFG+L+ E+ T+G++P+   +N +V+E +  G+R+  P   P+S++E+M  CW 
Sbjct: 445 IKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWK 504

Query: 505 EKPEGRPTFAEL 516
           + PE RPTF  L
Sbjct: 505 KDPEERPTFEYL 516


>gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
           isoform B [Homo sapiens]
          Length = 491

 Score =  331 bits (848), Expect = 1e-90
 Identities = 179/437 (40%), Positives = 269/437 (61%), Gaps = 24/437 (5%)

Query: 87  VKALYDFLPREPCNLALRRAEEYLILEKYNPHWWKARDRLGN-EGLIPSNYVTENKITNL 145
           V ALY +    P +L+ ++ E+  +LE++   WWKA+  L   EG IPSNYV   K+  L
Sbjct: 47  VVALYPYDGIHPDDLSFKKGEKMKVLEEHG-EWWKAKSLLTKKEGFIPSNYVA--KLNTL 103

Query: 146 EIYEWYHRNITRNQAEH-LLRQESKEGAFIVRDSRHL-GSYTISVFMGARRSTEAA---- 199
           E  EW+ ++ITR  AE  LL   +  GAF++R+S  L GS+++SV     R  +      
Sbjct: 104 ETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSV-----RDFDPVHGDV 158

Query: 200 IKHYQIKKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAGF 259
           IKHY+I+  D+G +Y++ R  F  I ++I ++Q  A GL  RL        +C+      
Sbjct: 159 IKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEK------ACISPKPQK 212

Query: 260 SYEK--WEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKV 317
            ++K  WEI    +  +K +G+GQFG V +G + +  +VA+K +  G+MS + F+EEA +
Sbjct: 213 PWDKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANL 272

Query: 318 MMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKG-KLRKEMLLSVCQDICE 376
           M  L H KLV+LY V  + +P+YI+TE+M  G LL++L+ ++G K+    L+     I E
Sbjct: 273 MKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAE 332

Query: 377 GMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPE 436
           GM Y+ER  YIHRDL A N LVS + + KI+DFG+ R + D+EY +  GAKFPIKW+ PE
Sbjct: 333 GMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPE 392

Query: 437 VFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIY 496
              F  ++ KSDVWSFG+L++E+ T GK+P+  ++N  V+ A+S+G+R+ R    P  +Y
Sbjct: 393 AINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELY 452

Query: 497 EVMYSCWHEKPEGRPTF 513
           ++M  CW EK E RPTF
Sbjct: 453 DIMKMCWKEKAEERPTF 469


>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
           sapiens]
          Length = 536

 Score =  328 bits (842), Expect = 6e-90
 Identities = 179/440 (40%), Positives = 263/440 (59%), Gaps = 16/440 (3%)

Query: 89  ALYDFLPREPCNLALRRAEEYLILEKYNPHWWKARD-RLGNEGLIPSNYVTENKITNLEI 147
           ALYD+  R   +L+ ++ E   I+      WW A     G  G IPSNYV  +   +++ 
Sbjct: 91  ALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSD--SIQA 148

Query: 148 YEWYHRNITRNQAEHLL-RQESKEGAFIVRDSRHL-GSYTISV--FMGARRSTEAAIKHY 203
            EWY   ITR ++E LL   E+  G F+VR+S    G+Y +SV  F  A+      +KHY
Sbjct: 149 EEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLN---VKHY 205

Query: 204 QIKKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAGFSYEK 263
           +I+K DSG +Y+  R  F S+ +L+ Y+  +A GL  RL     +  +  P T G + + 
Sbjct: 206 KIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRL---TTVCPTSKPQTQGLAKDA 262

Query: 264 WEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSH 323
           WEI    L    ++G G FG V +G W    +VAIK +  G+MS E F++EA+VM KL H
Sbjct: 263 WEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRH 322

Query: 324 SKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKGK-LRKEMLLSVCQDICEGMEYLE 382
            KLVQLY V +  +P+YIVTE+M  G LL++L+   GK LR   L+ +   I  GM Y+E
Sbjct: 323 EKLVQLYAV-VSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVE 381

Query: 383 RNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNK 442
           R  Y+HRDL A N LV    + K++DFG+ R + D+EY +  GAKFPIKW+ PE  L+ +
Sbjct: 382 RMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 441

Query: 443 YSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSC 502
           ++ KSDVWSFG+L+ E+ T+G++P+    N +V++ +  G+R+  P   P S++++M  C
Sbjct: 442 FTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQC 501

Query: 503 WHEKPEGRPTFAELLRAVTE 522
           W ++PE RPTF E L+A  E
Sbjct: 502 WRKEPEERPTF-EYLQAFLE 520


>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
           sapiens]
          Length = 536

 Score =  328 bits (842), Expect = 6e-90
 Identities = 179/440 (40%), Positives = 263/440 (59%), Gaps = 16/440 (3%)

Query: 89  ALYDFLPREPCNLALRRAEEYLILEKYNPHWWKARD-RLGNEGLIPSNYVTENKITNLEI 147
           ALYD+  R   +L+ ++ E   I+      WW A     G  G IPSNYV  +   +++ 
Sbjct: 91  ALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSD--SIQA 148

Query: 148 YEWYHRNITRNQAEHLL-RQESKEGAFIVRDSRHL-GSYTISV--FMGARRSTEAAIKHY 203
            EWY   ITR ++E LL   E+  G F+VR+S    G+Y +SV  F  A+      +KHY
Sbjct: 149 EEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLN---VKHY 205

Query: 204 QIKKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAGFSYEK 263
           +I+K DSG +Y+  R  F S+ +L+ Y+  +A GL  RL     +  +  P T G + + 
Sbjct: 206 KIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRL---TTVCPTSKPQTQGLAKDA 262

Query: 264 WEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSH 323
           WEI    L    ++G G FG V +G W    +VAIK +  G+MS E F++EA+VM KL H
Sbjct: 263 WEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRH 322

Query: 324 SKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKGK-LRKEMLLSVCQDICEGMEYLE 382
            KLVQLY V +  +P+YIVTE+M  G LL++L+   GK LR   L+ +   I  GM Y+E
Sbjct: 323 EKLVQLYAV-VSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVE 381

Query: 383 RNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNK 442
           R  Y+HRDL A N LV    + K++DFG+ R + D+EY +  GAKFPIKW+ PE  L+ +
Sbjct: 382 RMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 441

Query: 443 YSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSC 502
           ++ KSDVWSFG+L+ E+ T+G++P+    N +V++ +  G+R+  P   P S++++M  C
Sbjct: 442 FTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQC 501

Query: 503 WHEKPEGRPTFAELLRAVTE 522
           W ++PE RPTF E L+A  E
Sbjct: 502 WRKEPEERPTF-EYLQAFLE 520


>gi|112789548 lymphocyte-specific protein tyrosine kinase precursor
           [Homo sapiens]
          Length = 509

 Score =  328 bits (840), Expect = 1e-89
 Identities = 175/451 (38%), Positives = 276/451 (61%), Gaps = 15/451 (3%)

Query: 76  PPSEVAEEKIQVKALYDFLPREPCNLALRRAEEYLILEKYNPHWWKARD-RLGNEGLIPS 134
           PP+   ++ + + AL+ + P    +L   + E+  ILE+ +  WWKA+    G EG IP 
Sbjct: 56  PPASPLQDNLVI-ALHSYEPSHDGDLGFEKGEQLRILEQ-SGEWWKAQSLTTGQEGFIPF 113

Query: 135 NYVTENKITNLEIYEWYHRNITRNQAEH-LLRQESKEGAFIVRDSRHL-GSYTISVFMGA 192
           N+V   K  +LE   W+ +N++R  AE  LL   +  G+F++R+S    GS+++SV    
Sbjct: 114 NFVA--KANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFD 171

Query: 193 RRSTEAAIKHYQIKKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSC 252
           +   E  +KHY+I+  D+G +Y++ R  F  + EL+ ++ + + GL TRL  P       
Sbjct: 172 QNQGEV-VKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQ 230

Query: 253 LPATAGFSYEKWEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFI 312
            P    +  ++WE+    L  ++ +G+GQFG V +G +  H +VA+K++ +GSMS + F+
Sbjct: 231 KP----WWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFL 286

Query: 313 EEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKG-KLRKEMLLSVC 371
            EA +M +L H +LV+LY V  Q +P+YI+TE+MENG L+++L+   G KL    LL + 
Sbjct: 287 AEANLMKQLQHQRLVRLYAVVTQ-EPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMA 345

Query: 372 QDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIK 431
             I EGM ++E   YIHRDL A N LVS T   KI+DFG+ R + D+EY +  GAKFPIK
Sbjct: 346 AQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIK 405

Query: 432 WSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLA 491
           W+ PE   +  ++ KSDVWSFG+L+ E+ T G++P+   +N +V++ +  G+R+ RP   
Sbjct: 406 WTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNC 465

Query: 492 PMSIYEVMYSCWHEKPEGRPTFAELLRAVTE 522
           P  +Y++M  CW E+PE RPTF + LR+V E
Sbjct: 466 PEELYQLMRLCWKERPEDRPTF-DYLRSVLE 495


>gi|112789546 lymphocyte-specific protein tyrosine kinase precursor
           [Homo sapiens]
          Length = 509

 Score =  328 bits (840), Expect = 1e-89
 Identities = 175/451 (38%), Positives = 276/451 (61%), Gaps = 15/451 (3%)

Query: 76  PPSEVAEEKIQVKALYDFLPREPCNLALRRAEEYLILEKYNPHWWKARD-RLGNEGLIPS 134
           PP+   ++ + + AL+ + P    +L   + E+  ILE+ +  WWKA+    G EG IP 
Sbjct: 56  PPASPLQDNLVI-ALHSYEPSHDGDLGFEKGEQLRILEQ-SGEWWKAQSLTTGQEGFIPF 113

Query: 135 NYVTENKITNLEIYEWYHRNITRNQAEH-LLRQESKEGAFIVRDSRHL-GSYTISVFMGA 192
           N+V   K  +LE   W+ +N++R  AE  LL   +  G+F++R+S    GS+++SV    
Sbjct: 114 NFVA--KANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFD 171

Query: 193 RRSTEAAIKHYQIKKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSC 252
           +   E  +KHY+I+  D+G +Y++ R  F  + EL+ ++ + + GL TRL  P       
Sbjct: 172 QNQGEV-VKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQ 230

Query: 253 LPATAGFSYEKWEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFI 312
            P    +  ++WE+    L  ++ +G+GQFG V +G +  H +VA+K++ +GSMS + F+
Sbjct: 231 KP----WWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFL 286

Query: 313 EEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKG-KLRKEMLLSVC 371
            EA +M +L H +LV+LY V  Q +P+YI+TE+MENG L+++L+   G KL    LL + 
Sbjct: 287 AEANLMKQLQHQRLVRLYAVVTQ-EPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMA 345

Query: 372 QDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIK 431
             I EGM ++E   YIHRDL A N LVS T   KI+DFG+ R + D+EY +  GAKFPIK
Sbjct: 346 AQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIK 405

Query: 432 WSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLA 491
           W+ PE   +  ++ KSDVWSFG+L+ E+ T G++P+   +N +V++ +  G+R+ RP   
Sbjct: 406 WTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNC 465

Query: 492 PMSIYEVMYSCWHEKPEGRPTFAELLRAVTE 522
           P  +Y++M  CW E+PE RPTF + LR+V E
Sbjct: 466 PEELYQLMRLCWKERPEDRPTF-DYLRSVLE 495


>gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]
          Length = 526

 Score =  327 bits (838), Expect = 2e-89
 Identities = 179/450 (39%), Positives = 274/450 (60%), Gaps = 18/450 (4%)

Query: 79  EVAEEKIQVKALYDFLPREPCNLALRRAEEYLILEKYNPHWWKARD-RLGNEGLIPSNYV 137
           E   E I V ALYD+      +L+ ++ ++ ++LE+ +  WWKAR      EG IPSNYV
Sbjct: 75  EAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVLEE-SGEWWKARSLATRKEGYIPSNYV 133

Query: 138 TENKITNLEIYEWYHRNITRNQAEH-LLRQESKEGAFIVRDSRHL-GSYTISVFMGARRS 195
              ++ +LE  EW+ + I+R  AE  LL   +  G+F++RDS    GSY++SV     R 
Sbjct: 134 A--RVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQ 191

Query: 196 TEAAIKHYQIKKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPA 255
            +  +KHY+I+  D+G +Y++ R  F ++ EL+ +++    GL  +L  P      C+ +
Sbjct: 192 GDT-VKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVP------CMSS 244

Query: 256 TAGFSYEK--WEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIE 313
                +EK  WEI    L   K++G+GQFG V +  +  H +VA+K +  GSMS E F+ 
Sbjct: 245 KPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLA 304

Query: 314 EAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKG-KLRKEMLLSVCQ 372
           EA VM  L H KLV+L+ V + ++P+YI+TEFM  G LL++L+ ++G K     L+    
Sbjct: 305 EANVMKTLQHDKLVKLHAV-VTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSA 363

Query: 373 DICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKW 432
            I EGM ++E+  YIHRDL A N LVS++ + KI+DFG+ R + D+EY +  GAKFPIKW
Sbjct: 364 QIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKW 423

Query: 433 SPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAP 492
           + PE   F  ++ KSDVWSFG+L+ E+ T G++P+   SN +V+ A+  G+R+ RP   P
Sbjct: 424 TAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCP 483

Query: 493 MSIYEVMYSCWHEKPEGRPTFAELLRAVTE 522
             +Y +M  CW  +PE RPTF E +++V +
Sbjct: 484 EELYNIMMRCWKNRPEERPTF-EYIQSVLD 512


>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
          Length = 1146

 Score =  322 bits (826), Expect = 4e-88
 Identities = 189/522 (36%), Positives = 294/522 (56%), Gaps = 36/522 (6%)

Query: 4   SSYNTIQSVFCCCCCCSVQKRQMRTQISLSTDEELPEKYTQRRRPWLSQLSNKKQSNTGR 63
           +SY   Q    CC C              +++  LP+      RP+   +  + Q+    
Sbjct: 11  NSYGRDQDTSLCCLCTE------------ASESALPDLTEALHRPYGCDV--EPQALNEA 56

Query: 64  VQPSKRKPLPPLPPSEVAEEKIQVKALYDFLPREPCNLALRRAEEYLILE-KYNPHWWKA 122
           ++ S ++ L  L  +E ++  + V ALYDF+      L++ + E+  +L    N  W + 
Sbjct: 57  IRWSSKENL--LGATE-SDPNLFV-ALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEV 112

Query: 123 RDRLGNEGLIPSNYVTENKITNLEIYEWYHRNITRNQAEHLLRQESKEGAFIVRDSRHL- 181
           R + G +G +PSNY+T   + +LE + WYH  ++R+ AE+LL      G+F+VR+S    
Sbjct: 113 RSKNG-QGWVPSNYITP--VNSLEKHSWYHGPVSRSAAEYLL-SSLINGSFLVRESESSP 168

Query: 182 GSYTISVFMGARRSTEAAIKHYQIKKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTR 241
           G  +IS+        E  + HY+I     G+ YV     F ++ EL+ +H   A GL+T 
Sbjct: 169 GQLSISL------RYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTT 222

Query: 242 LRYPVGLMGSCLPATAGFS--YEKWEIDPSELAFIKEIGSGQFGVVHLGEWRSH-IQVAI 298
           L YP        P   G S  ++KWE++ +++    ++G GQ+G V++G W+ + + VA+
Sbjct: 223 LHYPAPKCNK--PTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAV 280

Query: 299 KAINEGSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRE- 357
           K + E +M  E+F++EA VM ++ H  LVQL GVC    P YIVTE+M  G LL+YLRE 
Sbjct: 281 KTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLREC 340

Query: 358 NKGKLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLD 417
           N+ ++   +LL +   I   MEYLE+  +IHRDLAARNCLV    +VK++DFG++R +  
Sbjct: 341 NREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTG 400

Query: 418 DEYVSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVE 477
           D Y +  GAKFPIKW+ PE   +N +S KSDVW+FGVL+WE+ T G  P+      QV +
Sbjct: 401 DTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYD 460

Query: 478 AISEGFRLYRPHLAPMSIYEVMYSCWHEKPEGRPTFAELLRA 519
            + +G+R+ +P   P  +YE+M +CW   P  RP+FAE  +A
Sbjct: 461 LLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQA 502


>gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]
          Length = 505

 Score =  322 bits (825), Expect = 5e-88
 Identities = 183/457 (40%), Positives = 279/457 (61%), Gaps = 21/457 (4%)

Query: 73  PPLPPSEVAEEKIQVKALYDFLPREPCNLALRRAEEYLILEKYNPHWWKARDRL-GNEGL 131
           PP P   + E+K  V ALYD+      +L + + E+  +L K    WW AR  + G EG 
Sbjct: 49  PPPPDEHLDEDKHFVVALYDYTAMNDRDLQMLKGEKLQVL-KGTGDWWLARSLVTGREGY 107

Query: 132 IPSNYVTENKITNLEIYEWYHRNITRNQAEH-LLRQESKEGAFIVRDSR-HLGSYTISVF 189
           +PSN+V   ++ +LE+  W+ R+  R +AE  LL   +K G+F++R+S  + G++++SV 
Sbjct: 108 VPSNFVA--RVESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVK 165

Query: 190 MGARRSTEAAIKHYQIKKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLM 249
               +     IKHY+I+  D G +Y++ R  F S+  L+ ++     GL  RL  P    
Sbjct: 166 DVTTQGE--LIKHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLP---- 219

Query: 250 GSCL-PATAG-FSYEKWEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMS 307
             C+ PA    ++ ++WEI    L  ++++GSGQFG V +G ++++++VAIK + EG+MS
Sbjct: 220 --CVRPAPQNPWAQDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMS 277

Query: 308 EEDFIEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKG-KLRKEM 366
            E F+ EA VM  L H +LV+LY V + ++P+YIVTE+M  GCLL++L+ ++G +L    
Sbjct: 278 PEAFLGEANVMKALQHERLVRLYAV-VTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPR 336

Query: 367 LLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGA 426
           L+ +   I EGM Y+ER   IHRDL A N LVS     KI+DFG+ R ++D EY +  GA
Sbjct: 337 LIDMSAQIAEGMAYIERMNSIHRDLRAANILVSEALCCKIADFGLAR-IIDSEYTAQEGA 395

Query: 427 KFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLY 486
           KFPIKW+ PE   F  ++ K+DVWSFGVL+ EV T G++P+   SN +V+  +  G+R+ 
Sbjct: 396 KFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMP 455

Query: 487 RPHLAPMSIYE-VMYSCWHEKPEGRPTFAELLRAVTE 522
           RP   P  +Y  V+  CW  +PE RPTF E L++V E
Sbjct: 456 RPDTCPPELYRGVIAECWRSRPEERPTF-EFLQSVLE 491


>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
          Length = 1167

 Score =  322 bits (825), Expect = 5e-88
 Identities = 173/437 (39%), Positives = 261/437 (59%), Gaps = 18/437 (4%)

Query: 89  ALYDFLPREPCNLALRRAEEYLILE-KYNPHWWKARDRLGNEGLIPSNYVTENKITNLEI 147
           ALYDF+      L++ + E+  +L    N  W + R + G +G +PSNY+T   + +LE 
Sbjct: 99  ALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNG-QGWVPSNYITP--VNSLEK 155

Query: 148 YEWYHRNITRNQAEHLLRQESKEGAFIVRDSRHL-GSYTISVFMGARRSTEAAIKHYQIK 206
           + WYH  ++R+ AE+LL      G+F+VR+S    G  +IS+        E  + HY+I 
Sbjct: 156 HSWYHGPVSRSAAEYLL-SSLINGSFLVRESESSPGQLSISL------RYEGRVYHYRIN 208

Query: 207 KNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAGFS--YEKW 264
               G+ YV     F ++ EL+ +H   A GL+T L YP        P   G S  ++KW
Sbjct: 209 TTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNK--PTVYGVSPIHDKW 266

Query: 265 EIDPSELAFIKEIGSGQFGVVHLGEWRSH-IQVAIKAINEGSMSEEDFIEEAKVMMKLSH 323
           E++ +++    ++G GQ+G V++G W+ + + VA+K + E +M  E+F++EA VM ++ H
Sbjct: 267 EMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 326

Query: 324 SKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRE-NKGKLRKEMLLSVCQDICEGMEYLE 382
             LVQL GVC    P YIVTE+M  G LL+YLRE N+ ++   +LL +   I   MEYLE
Sbjct: 327 PNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLE 386

Query: 383 RNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNK 442
           +  +IHRDLAARNCLV    +VK++DFG++R +  D Y +  GAKFPIKW+ PE   +N 
Sbjct: 387 KKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNT 446

Query: 443 YSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSC 502
           +S KSDVW+FGVL+WE+ T G  P+      QV + + +G+R+ +P   P  +YE+M +C
Sbjct: 447 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRAC 506

Query: 503 WHEKPEGRPTFAELLRA 519
           W   P  RP+FAE  +A
Sbjct: 507 WKWSPADRPSFAETHQA 523


>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
          Length = 1182

 Score =  322 bits (825), Expect = 5e-88
 Identities = 173/437 (39%), Positives = 261/437 (59%), Gaps = 18/437 (4%)

Query: 89  ALYDFLPREPCNLALRRAEEYLILE-KYNPHWWKARDRLGNEGLIPSNYVTENKITNLEI 147
           ALYDF+      L++ + E+  +L    N  W + R + G +G +PSNY+T   + +LE 
Sbjct: 114 ALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNG-QGWVPSNYITP--VNSLEK 170

Query: 148 YEWYHRNITRNQAEHLLRQESKEGAFIVRDSRHL-GSYTISVFMGARRSTEAAIKHYQIK 206
           + WYH  ++R+ AE+LL      G+F+VR+S    G  +IS+        E  + HY+I 
Sbjct: 171 HSWYHGPVSRSAAEYLL-SSLINGSFLVRESESSPGQLSISL------RYEGRVYHYRIN 223

Query: 207 KNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAGFS--YEKW 264
               G+ YV     F ++ EL+ +H   A GL+T L YP        P   G S  ++KW
Sbjct: 224 TTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNK--PTVYGVSPIHDKW 281

Query: 265 EIDPSELAFIKEIGSGQFGVVHLGEWRSH-IQVAIKAINEGSMSEEDFIEEAKVMMKLSH 323
           E++ +++    ++G GQ+G V++G W+ + + VA+K + E +M  E+F++EA VM ++ H
Sbjct: 282 EMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 341

Query: 324 SKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRE-NKGKLRKEMLLSVCQDICEGMEYLE 382
             LVQL GVC    P YIVTE+M  G LL+YLRE N+ ++   +LL +   I   MEYLE
Sbjct: 342 PNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLE 401

Query: 383 RNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNK 442
           +  +IHRDLAARNCLV    +VK++DFG++R +  D Y +  GAKFPIKW+ PE   +N 
Sbjct: 402 KKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNT 461

Query: 443 YSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSC 502
           +S KSDVW+FGVL+WE+ T G  P+      QV + + +G+R+ +P   P  +YE+M +C
Sbjct: 462 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRAC 521

Query: 503 WHEKPEGRPTFAELLRA 519
           W   P  RP+FAE  +A
Sbjct: 522 WKWSPADRPSFAETHQA 538


>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
          Length = 542

 Score =  322 bits (825), Expect = 5e-88
 Identities = 173/437 (39%), Positives = 261/437 (59%), Gaps = 18/437 (4%)

Query: 89  ALYDFLPREPCNLALRRAEEYLILE-KYNPHWWKARDRLGNEGLIPSNYVTENKITNLEI 147
           ALYDF+      L++ + E+  +L    N  W + R + G +G +PSNY+T   + +LE 
Sbjct: 93  ALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNG-QGWVPSNYITP--VNSLEK 149

Query: 148 YEWYHRNITRNQAEHLLRQESKEGAFIVRDSRHL-GSYTISVFMGARRSTEAAIKHYQIK 206
           + WYH  ++R+ AE+LL      G+F+VR+S    G  +IS+        E  + HY+I 
Sbjct: 150 HSWYHGPVSRSAAEYLL-SSLINGSFLVRESESSPGQLSISL------RYEGRVYHYRIN 202

Query: 207 KNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAGFS--YEKW 264
               G+ YV     F ++ EL+ +H   A GL+T L YP        P   G S  ++KW
Sbjct: 203 TTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNK--PTVYGVSPIHDKW 260

Query: 265 EIDPSELAFIKEIGSGQFGVVHLGEWRSH-IQVAIKAINEGSMSEEDFIEEAKVMMKLSH 323
           E++ +++    ++G GQ+G V++G W+ + + VA+K + E +M  E+F++EA VM ++ H
Sbjct: 261 EMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 320

Query: 324 SKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRE-NKGKLRKEMLLSVCQDICEGMEYLE 382
             LVQL GVC    P YIVTE+M  G LL+YLRE N+ ++   +LL +   I   MEYLE
Sbjct: 321 PNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLE 380

Query: 383 RNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNK 442
           +  +IHRDLAARNCLV    +VK++DFG++R +  D Y +  GAKFPIKW+ PE   +N 
Sbjct: 381 KKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNT 440

Query: 443 YSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSC 502
           +S KSDVW+FGVL+WE+ T G  P+      QV + + +G+R+ +P   P  +YE+M +C
Sbjct: 441 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRAC 500

Query: 503 WHEKPEGRPTFAELLRA 519
           W   P  RP+FAE  +A
Sbjct: 501 WKWSPADRPSFAETHQA 517


>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
          Length = 1064

 Score =  322 bits (825), Expect = 5e-88
 Identities = 173/437 (39%), Positives = 261/437 (59%), Gaps = 18/437 (4%)

Query: 89  ALYDFLPREPCNLALRRAEEYLILE-KYNPHWWKARDRLGNEGLIPSNYVTENKITNLEI 147
           ALYDF+      L++ + E+  +L    N  W + R + G +G +PSNY+T   + +LE 
Sbjct: 99  ALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNG-QGWVPSNYITP--VNSLEK 155

Query: 148 YEWYHRNITRNQAEHLLRQESKEGAFIVRDSRHL-GSYTISVFMGARRSTEAAIKHYQIK 206
           + WYH  ++R+ AE+LL      G+F+VR+S    G  +IS+        E  + HY+I 
Sbjct: 156 HSWYHGPVSRSAAEYLL-SSLINGSFLVRESESSPGQLSISL------RYEGRVYHYRIN 208

Query: 207 KNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAGFS--YEKW 264
               G+ YV     F ++ EL+ +H   A GL+T L YP        P   G S  ++KW
Sbjct: 209 TTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNK--PTVYGVSPIHDKW 266

Query: 265 EIDPSELAFIKEIGSGQFGVVHLGEWRSH-IQVAIKAINEGSMSEEDFIEEAKVMMKLSH 323
           E++ +++    ++G GQ+G V++G W+ + + VA+K + E +M  E+F++EA VM ++ H
Sbjct: 267 EMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 326

Query: 324 SKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRE-NKGKLRKEMLLSVCQDICEGMEYLE 382
             LVQL GVC    P YIVTE+M  G LL+YLRE N+ ++   +LL +   I   MEYLE
Sbjct: 327 PNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLE 386

Query: 383 RNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNK 442
           +  +IHRDLAARNCLV    +VK++DFG++R +  D Y +  GAKFPIKW+ PE   +N 
Sbjct: 387 KKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNT 446

Query: 443 YSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSC 502
           +S KSDVW+FGVL+WE+ T G  P+      QV + + +G+R+ +P   P  +YE+M +C
Sbjct: 447 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRAC 506

Query: 503 WHEKPEGRPTFAELLRA 519
           W   P  RP+FAE  +A
Sbjct: 507 WKWSPADRPSFAETHQA 523


>gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo
           sapiens]
          Length = 529

 Score =  320 bits (821), Expect = 2e-87
 Identities = 175/432 (40%), Positives = 255/432 (59%), Gaps = 11/432 (2%)

Query: 89  ALYDFLPREPCNLALRRAEEYLILEKYNPHWWKARD-RLGNEGLIPSNYVTENKITNLEI 147
           ALYD+  R   +L   + E++ IL      WW+AR    G  G IPSNYV    + +++ 
Sbjct: 84  ALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAP--VDSIQA 141

Query: 148 YEWYHRNITRNQAEH-LLRQESKEGAFIVRDSRHL-GSYTISVFMGARRSTEAAIKHYQI 205
            EWY   I R  AE  LL   + +GAF++R+S    G+Y++S+     ++    +KHY+I
Sbjct: 142 EEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSI-RDWDQTRGDHVKHYKI 200

Query: 206 KKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAGFSYEKWE 265
           +K D G +Y+  R  F S+ EL+ ++     GL   L  P  +M    P T G + + WE
Sbjct: 201 RKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMK---PQTLGLAKDAWE 257

Query: 266 IDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSHSK 325
           I  S +   + +G+G FG V LG W    +VA+K +  G+MS + F+EEA+VM  L H K
Sbjct: 258 ISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDK 317

Query: 326 LVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKGK-LRKEMLLSVCQDICEGMEYLERN 384
           LVQLY V +  +P+YIVTEFM +G LL++L+  +G+ LR   L+ +   + EGM Y+ER 
Sbjct: 318 LVQLYAV-VSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERM 376

Query: 385 GYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNKYS 444
            YIHRDL A N LV      KI+DFG+ R + DDEY    G+KFPIKW+ PE  LF +++
Sbjct: 377 NYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFT 436

Query: 445 SKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCWH 504
            KSDVWSFG+L+ E+ T+G++P+   +  +V+E + +G+ +  P   P S+YE M   W 
Sbjct: 437 IKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWR 496

Query: 505 EKPEGRPTFAEL 516
             PE RPTF  L
Sbjct: 497 LDPEERPTFEYL 508


>gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo
           sapiens]
          Length = 529

 Score =  320 bits (821), Expect = 2e-87
 Identities = 175/432 (40%), Positives = 255/432 (59%), Gaps = 11/432 (2%)

Query: 89  ALYDFLPREPCNLALRRAEEYLILEKYNPHWWKARD-RLGNEGLIPSNYVTENKITNLEI 147
           ALYD+  R   +L   + E++ IL      WW+AR    G  G IPSNYV    + +++ 
Sbjct: 84  ALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAP--VDSIQA 141

Query: 148 YEWYHRNITRNQAEH-LLRQESKEGAFIVRDSRHL-GSYTISVFMGARRSTEAAIKHYQI 205
            EWY   I R  AE  LL   + +GAF++R+S    G+Y++S+     ++    +KHY+I
Sbjct: 142 EEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSI-RDWDQTRGDHVKHYKI 200

Query: 206 KKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAGFSYEKWE 265
           +K D G +Y+  R  F S+ EL+ ++     GL   L  P  +M    P T G + + WE
Sbjct: 201 RKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMK---PQTLGLAKDAWE 257

Query: 266 IDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSHSK 325
           I  S +   + +G+G FG V LG W    +VA+K +  G+MS + F+EEA+VM  L H K
Sbjct: 258 ISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDK 317

Query: 326 LVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKGK-LRKEMLLSVCQDICEGMEYLERN 384
           LVQLY V +  +P+YIVTEFM +G LL++L+  +G+ LR   L+ +   + EGM Y+ER 
Sbjct: 318 LVQLYAV-VSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERM 376

Query: 385 GYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNKYS 444
            YIHRDL A N LV      KI+DFG+ R + DDEY    G+KFPIKW+ PE  LF +++
Sbjct: 377 NYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFT 436

Query: 445 SKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCWH 504
            KSDVWSFG+L+ E+ T+G++P+   +  +V+E + +G+ +  P   P S+YE M   W 
Sbjct: 437 IKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWR 496

Query: 505 EKPEGRPTFAEL 516
             PE RPTF  L
Sbjct: 497 LDPEERPTFEYL 508


>gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo
           sapiens]
          Length = 529

 Score =  320 bits (821), Expect = 2e-87
 Identities = 175/432 (40%), Positives = 255/432 (59%), Gaps = 11/432 (2%)

Query: 89  ALYDFLPREPCNLALRRAEEYLILEKYNPHWWKARD-RLGNEGLIPSNYVTENKITNLEI 147
           ALYD+  R   +L   + E++ IL      WW+AR    G  G IPSNYV    + +++ 
Sbjct: 84  ALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAP--VDSIQA 141

Query: 148 YEWYHRNITRNQAEH-LLRQESKEGAFIVRDSRHL-GSYTISVFMGARRSTEAAIKHYQI 205
            EWY   I R  AE  LL   + +GAF++R+S    G+Y++S+     ++    +KHY+I
Sbjct: 142 EEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSI-RDWDQTRGDHVKHYKI 200

Query: 206 KKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAGFSYEKWE 265
           +K D G +Y+  R  F S+ EL+ ++     GL   L  P  +M    P T G + + WE
Sbjct: 201 RKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMK---PQTLGLAKDAWE 257

Query: 266 IDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSHSK 325
           I  S +   + +G+G FG V LG W    +VA+K +  G+MS + F+EEA+VM  L H K
Sbjct: 258 ISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDK 317

Query: 326 LVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKGK-LRKEMLLSVCQDICEGMEYLERN 384
           LVQLY V +  +P+YIVTEFM +G LL++L+  +G+ LR   L+ +   + EGM Y+ER 
Sbjct: 318 LVQLYAV-VSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERM 376

Query: 385 GYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNKYS 444
            YIHRDL A N LV      KI+DFG+ R + DDEY    G+KFPIKW+ PE  LF +++
Sbjct: 377 NYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFT 436

Query: 445 SKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCWH 504
            KSDVWSFG+L+ E+ T+G++P+   +  +V+E + +G+ +  P   P S+YE M   W 
Sbjct: 437 IKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWR 496

Query: 505 EKPEGRPTFAEL 516
             PE RPTF  L
Sbjct: 497 LDPEERPTFEYL 508


>gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]
          Length = 543

 Score =  317 bits (811), Expect = 2e-86
 Identities = 170/432 (39%), Positives = 255/432 (59%), Gaps = 17/432 (3%)

Query: 89  ALYDFLPREPCNLALRRAEEYLILEKYNPHWWKARD-RLGNEGLIPSNYVTENKITNLEI 147
           ALYD+  R   +L+ ++ E + I+      WW+AR    G  G IPSNYV      +++ 
Sbjct: 98  ALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGYIPSNYVAP--ADSIQA 155

Query: 148 YEWYHRNITRNQAEHLLRQESKE-GAFIVRDSRHL-GSYTISVFMGARRSTEAA---IKH 202
            EWY   + R  AE LL     + G F+VR+S    G+Y++S+    R   E     +KH
Sbjct: 156 EEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSI----RDWDEIRGDNVKH 211

Query: 203 YQIKKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAGFSYE 262
           Y+I+K D+G +Y+  R  F ++ +L+ ++  +A GL  +L     +  +  P T G + +
Sbjct: 212 YKIRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKL---TTVCPTVKPQTQGLAKD 268

Query: 263 KWEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKLS 322
            WEI    L    ++G G FG V +G W    +VAIK +  G+M  E F++EA++M KL 
Sbjct: 269 AWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLR 328

Query: 323 HSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKGK-LRKEMLLSVCQDICEGMEYL 381
           H KLV LY V +  +P+YIVTEFM  G LL++L+E  GK L+   L+ +   I +GM Y+
Sbjct: 329 HDKLVPLYAV-VSEEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYI 387

Query: 382 ERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFN 441
           ER  YIHRDL A N LV    + KI+DFG+ R + D+EY +  GAKFPIKW+ PE  L+ 
Sbjct: 388 ERMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYG 447

Query: 442 KYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYS 501
           +++ KSDVWSFG+L  E+ T+G++P+    N +V+E +  G+R+  P   P S++E+M  
Sbjct: 448 RFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNL 507

Query: 502 CWHEKPEGRPTF 513
           CW + P+ RPTF
Sbjct: 508 CWKKDPDERPTF 519


>gi|4503787 fyn-related kinase [Homo sapiens]
          Length = 505

 Score =  315 bits (807), Expect = 6e-86
 Identities = 173/455 (38%), Positives = 263/455 (57%), Gaps = 27/455 (5%)

Query: 89  ALYDFLPREPCNLALRRAEEYLILEKYNPHWWKARD----RLGN----EGLIPSNYVTEN 140
           AL+D+  R   +L+ R  ++  +L+  +  WW AR     R G+    +G IPSNYV E+
Sbjct: 49  ALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVAED 108

Query: 141 KITNLEIYEWYHRNITRNQAE-HLLRQESKEGAFIVRDSR-HLGSYTISVFMGARRSTEA 198
           +  +L+   W+   I R+ AE  LL  E+K G+F++R+S    G +++SV  GA      
Sbjct: 109 R--SLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGA------ 160

Query: 199 AIKHYQIKKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAG 258
            +KHY+IK+ D G +++  R  F ++ E + ++   + GL  +L  P   +   +PA   
Sbjct: 161 VVKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPC--LKIQVPAPFD 218

Query: 259 FSY---EKWEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEA 315
            SY   ++WEID + +  +K +GSGQFG V  G W +   VA+K +  GSM   DF+ EA
Sbjct: 219 LSYKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREA 278

Query: 316 KVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKG-KLRKEMLLSVCQDI 374
           ++M  L H KL+QLY VC    P+YI+TE M +G L  YL+ + G K+     + +   +
Sbjct: 279 QIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQV 338

Query: 375 CEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTR-YVLDDE--YVSSFGAKFPIK 431
             GM YLE   YIHRDLAARN LV    I K++DFG+ R + +D+E  Y S    K P+K
Sbjct: 339 ASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVK 398

Query: 432 WSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLA 491
           W+ PE    NK+S KSDVWSFG+L++E+ T GKMP+   +  QV++ +++ +RL +P   
Sbjct: 399 WTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNC 458

Query: 492 PMSIYEVMYSCWHEKPEGRPTFAELLRAVTEIAET 526
           P   Y +M  CW+ +P+ RPTF  L   + +  ET
Sbjct: 459 PQQFYNIMLECWNAEPKERPTFETLRWKLEDYFET 493


>gi|187475373 c-src tyrosine kinase [Homo sapiens]
          Length = 450

 Score =  285 bits (729), Expect = 7e-77
 Identities = 161/415 (38%), Positives = 250/415 (60%), Gaps = 22/415 (5%)

Query: 116 NPHWWKARDRLGNEGLIPSNYVTENKI----TNLEIYEWYHRNITRNQAEHLLRQESKEG 171
           +P+W+KA++++G EG+IP+NYV + +     T L +  W+H  ITR QAE LL    + G
Sbjct: 44  DPNWYKAKNKVGREGIIPANYVQKREGVKAGTKLSLMPWFHGKITREQAERLL-YPPETG 102

Query: 172 AFIVRDSRHL-GSYTISVFMGARRSTEAAIKHYQIKKNDSGQWYVAERHAFQSIPELIWY 230
            F+VR+S +  G YT+ V      S +  ++HY+I  + S +  + E   F+++ +L+ +
Sbjct: 103 LFLVRESTNYPGDYTLCV------SCDGKVEHYRIMYHAS-KLSIDEEVYFENLMQLVEH 155

Query: 231 HQHNAAGLMTRLRYPVGLMGSCLPATAGFSYEKWEIDPSELAFIKEIGSGQFGVVHLGEW 290
           +  +A GL TRL  P  + G+ + A   F    W ++  EL  ++ IG G+FG V LG++
Sbjct: 156 YTSDADGLCTRLIKPKVMEGT-VAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDY 214

Query: 291 RSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRKP-LYIVTEFMENG 349
           R + +VA+K I   + ++  F+ EA VM +L HS LVQL GV ++ K  LYIVTE+M  G
Sbjct: 215 RGN-KVAVKCIKNDATAQA-FLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKG 272

Query: 350 CLLNYLREN-KGKLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISD 408
            L++YLR   +  L  + LL    D+CE MEYLE N ++HRDLAARN LVS   + K+SD
Sbjct: 273 SLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSD 332

Query: 409 FGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFE 468
           FG+T+     +       K P+KW+ PE     K+S+KSDVWSFG+L+WE+++ G++P+ 
Sbjct: 333 FGLTKEASSTQDTG----KLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYP 388

Query: 469 NKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCWHEKPEGRPTFAELLRAVTEI 523
                 VV  + +G+++  P   P ++YEVM +CWH     RP+F +L   +  I
Sbjct: 389 RIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQLEHI 443


>gi|4758078 c-src tyrosine kinase [Homo sapiens]
          Length = 450

 Score =  285 bits (729), Expect = 7e-77
 Identities = 161/415 (38%), Positives = 250/415 (60%), Gaps = 22/415 (5%)

Query: 116 NPHWWKARDRLGNEGLIPSNYVTENKI----TNLEIYEWYHRNITRNQAEHLLRQESKEG 171
           +P+W+KA++++G EG+IP+NYV + +     T L +  W+H  ITR QAE LL    + G
Sbjct: 44  DPNWYKAKNKVGREGIIPANYVQKREGVKAGTKLSLMPWFHGKITREQAERLL-YPPETG 102

Query: 172 AFIVRDSRHL-GSYTISVFMGARRSTEAAIKHYQIKKNDSGQWYVAERHAFQSIPELIWY 230
            F+VR+S +  G YT+ V      S +  ++HY+I  + S +  + E   F+++ +L+ +
Sbjct: 103 LFLVRESTNYPGDYTLCV------SCDGKVEHYRIMYHAS-KLSIDEEVYFENLMQLVEH 155

Query: 231 HQHNAAGLMTRLRYPVGLMGSCLPATAGFSYEKWEIDPSELAFIKEIGSGQFGVVHLGEW 290
           +  +A GL TRL  P  + G+ + A   F    W ++  EL  ++ IG G+FG V LG++
Sbjct: 156 YTSDADGLCTRLIKPKVMEGT-VAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDY 214

Query: 291 RSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRKP-LYIVTEFMENG 349
           R + +VA+K I   + ++  F+ EA VM +L HS LVQL GV ++ K  LYIVTE+M  G
Sbjct: 215 RGN-KVAVKCIKNDATAQA-FLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKG 272

Query: 350 CLLNYLREN-KGKLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISD 408
            L++YLR   +  L  + LL    D+CE MEYLE N ++HRDLAARN LVS   + K+SD
Sbjct: 273 SLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSD 332

Query: 409 FGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFE 468
           FG+T+     +       K P+KW+ PE     K+S+KSDVWSFG+L+WE+++ G++P+ 
Sbjct: 333 FGLTKEASSTQDTG----KLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYP 388

Query: 469 NKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCWHEKPEGRPTFAELLRAVTEI 523
                 VV  + +G+++  P   P ++YEVM +CWH     RP+F +L   +  I
Sbjct: 389 RIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQLEHI 443


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.135    0.419 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,114,897
Number of Sequences: 37866
Number of extensions: 913791
Number of successful extensions: 5575
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 654
Number of HSP's successfully gapped in prelim test: 320
Number of HSP's that attempted gapping in prelim test: 3340
Number of HSP's gapped (non-prelim): 1225
length of query: 527
length of database: 18,247,518
effective HSP length: 107
effective length of query: 420
effective length of database: 14,195,856
effective search space: 5962259520
effective search space used: 5962259520
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.