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Search of human proteins with 148234215
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|148234215 guanylate binding protein 4-like [Homo sapiens]
(638 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|148234215 guanylate binding protein 4-like [Homo sapiens] 1258 0.0
gi|31377634 guanylate binding protein 4 [Homo sapiens] 959 0.0
gi|157671915 guanylate binding protein family, member 6 [Homo sa... 868 0.0
gi|38327558 guanylate binding protein 2, interferon-inducible [H... 650 0.0
gi|166706903 guanylate binding protein 1, interferon-inducible, ... 649 0.0
gi|112382372 guanylate binding protein 3 [Homo sapiens] 647 0.0
gi|197333737 guanylate-binding protein 5 [Homo sapiens] 593 e-169
gi|16418425 guanylate-binding protein 5 [Homo sapiens] 593 e-169
gi|169160863 PREDICTED: similar to guanylate-binding protein 5 [... 102 1e-21
gi|208610002 atlastin GTPase 2 isoform 2 [Homo sapiens] 73 9e-13
gi|208610000 atlastin GTPase 2 isoform 1 [Homo sapiens] 73 9e-13
gi|189181742 atlastin GTPase 1 isoform b [Homo sapiens] 71 3e-12
gi|74024917 atlastin GTPase 1 isoform b [Homo sapiens] 71 3e-12
gi|19923445 atlastin GTPase 1 isoform a [Homo sapiens] 71 3e-12
gi|45827806 atlastin 3 [Homo sapiens] 67 7e-11
gi|58530840 desmoplakin isoform I [Homo sapiens] 54 6e-07
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 54 6e-07
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 54 6e-07
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 54 6e-07
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 54 6e-07
gi|71061468 centromere protein E [Homo sapiens] 53 1e-06
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 52 2e-06
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 51 4e-06
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 50 6e-06
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 50 6e-06
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 50 6e-06
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 50 6e-06
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 50 6e-06
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 50 6e-06
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 50 6e-06
>gi|148234215 guanylate binding protein 4-like [Homo sapiens]
Length = 638
Score = 1258 bits (3254), Expect = 0.0
Identities = 638/638 (100%), Positives = 638/638 (100%)
Query: 1 MASEIHMPGPVCLTENTKGHLVVNSEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAG 60
MASEIHMPGPVCLTENTKGHLVVNSEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAG
Sbjct: 1 MASEIHMPGPVCLTENTKGHLVVNSEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAG 60
Query: 61 KNKGFPLGCTVKSETKGIWMWCVPHPSKPNHTLILLDTEGLGDMEKSDPKSDSWIFALAV 120
KNKGFPLGCTVKSETKGIWMWCVPHPSKPNHTLILLDTEGLGDMEKSDPKSDSWIFALAV
Sbjct: 61 KNKGFPLGCTVKSETKGIWMWCVPHPSKPNHTLILLDTEGLGDMEKSDPKSDSWIFALAV 120
Query: 121 LLSSSFVYNSMGTINHQALEQLHYVTELTELIRAKSCPRPDEVEDSSEFVSFFPDFIWTV 180
LLSSSFVYNSMGTINHQALEQLHYVTELTELIRAKSCPRPDEVEDSSEFVSFFPDFIWTV
Sbjct: 121 LLSSSFVYNSMGTINHQALEQLHYVTELTELIRAKSCPRPDEVEDSSEFVSFFPDFIWTV 180
Query: 181 RDFTLELKLDGHPITEDEYLENALKLISGKNPQIQNSNKPREWIRHFFPKQKCFVFDRPI 240
RDFTLELKLDGHPITEDEYLENALKLISGKNPQIQNSNKPREWIRHFFPKQKCFVFDRPI
Sbjct: 181 RDFTLELKLDGHPITEDEYLENALKLISGKNPQIQNSNKPREWIRHFFPKQKCFVFDRPI 240
Query: 241 NDKKLLLHVEEVREDQLDSNFQMQSENFCSYIFTHAKTKTLREGILVTGNRLGMLVETYL 300
NDKKLLLHVEEVREDQLDSNFQMQSENFCSYIFTHAKTKTLREGILVTGNRLGMLVETYL
Sbjct: 241 NDKKLLLHVEEVREDQLDSNFQMQSENFCSYIFTHAKTKTLREGILVTGNRLGMLVETYL 300
Query: 301 DAINSGATPCLENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCE 360
DAINSGATPCLENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCE
Sbjct: 301 DAINSGATPCLENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCE 360
Query: 361 REAIAVFMEYSFKDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLTES 420
REAIAVFMEYSFKDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLTES
Sbjct: 361 REAIAVFMEYSFKDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLTES 420
Query: 421 ISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKA 480
ISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKA
Sbjct: 421 ISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKA 480
Query: 481 LTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMEREREN 540
LTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMEREREN
Sbjct: 481 LTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMEREREN 540
Query: 541 YMRELRKMLSHKMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENEEPSVFSQILDVA 600
YMRELRKMLSHKMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENEEPSVFSQILDVA
Sbjct: 541 YMRELRKMLSHKMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENEEPSVFSQILDVA 600
Query: 601 GSIFIAALPGAAKLVDLGMKILSSLCNRLRNPGKKIIS 638
GSIFIAALPGAAKLVDLGMKILSSLCNRLRNPGKKIIS
Sbjct: 601 GSIFIAALPGAAKLVDLGMKILSSLCNRLRNPGKKIIS 638
>gi|31377634 guanylate binding protein 4 [Homo sapiens]
Length = 640
Score = 959 bits (2480), Expect = 0.0
Identities = 484/622 (77%), Positives = 547/622 (87%), Gaps = 1/622 (0%)
Query: 3 SEIHMPGPVCLTENTKGHLVVNSEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKN 62
SE M P+CL EN + L VNS+ALEIL I+QPVVVVAIVGLYRTGKSYLMN+LAGK
Sbjct: 18 SESIMMAPICLVENQEEQLTVNSKALEILDKISQPVVVVAIVGLYRTGKSYLMNRLAGKR 77
Query: 63 KGFPLGCTVKSETKGIWMWCVPHPSKPNHTLILLDTEGLGDMEKSDPKSDSWIFALAVLL 122
GFPLG TV+SETKGIWMWCVPH SKPNHTL+LLDTEGLGD+EKS+PK+DSWIFALAVLL
Sbjct: 78 NGFPLGSTVQSETKGIWMWCVPHLSKPNHTLVLLDTEGLGDVEKSNPKNDSWIFALAVLL 137
Query: 123 SSSFVYNSMGTINHQALEQLHYVTELTELIRAKSCPRPDEVEDSSEFVSFFPDFIWTVRD 182
SSSFVYNS+ TINHQALEQLHYVTEL ELIRAKSCPRPDE EDSSEF SFFPDFIWTVRD
Sbjct: 138 SSSFVYNSVSTINHQALEQLHYVTELAELIRAKSCPRPDEAEDSSEFASFFPDFIWTVRD 197
Query: 183 FTLELKLDGHPITEDEYLENALKLISGKNPQIQNSNKPREWIRHFFPKQKCFVFDRPIND 242
FTLELKLDG+PITEDEYLENALKLI GKNP+IQNSN PRE IRHFF K+KCFVFDRP ND
Sbjct: 198 FTLELKLDGNPITEDEYLENALKLIPGKNPKIQNSNMPRECIRHFFRKRKCFVFDRPTND 257
Query: 243 KKLLLHVEEVREDQLDSNFQMQSENFCSYIFTHAKTKTLREGILVTGNRLGMLVETYLDA 302
K+ L H++EV E+ L+ +F MQS+NFCSYIFTHAKTKTLREGI+VTG RLG LV TY+DA
Sbjct: 258 KQYLNHMDEVPEENLERHFLMQSDNFCSYIFTHAKTKTLREGIIVTGKRLGTLVVTYVDA 317
Query: 303 INSGATPCLENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCERE 362
INSGA PCLENA+ LAQ EN AAVQRAA+HYSQQMAQQ+R PTDTLQELLDVHA CERE
Sbjct: 318 INSGAVPCLENAVTALAQLENPAAVQRAADHYSQQMAQQLRLPTDTLQELLDVHAACERE 377
Query: 363 AIAVFMEYSFKDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLTESIS 422
AIAVFME+SFKD++ EFQKKLVDT+EKKK DFVLQNEEASAKYCQAELKRLSE LTESI
Sbjct: 378 AIAVFMEHSFKDENHEFQKKLVDTIEKKKGDFVLQNEEASAKYCQAELKRLSEHLTESIL 437
Query: 423 RGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALT 482
RG F VPGGHN+YLE KK++E DY LVPRKGVKA+EVLQ+FLQSQVV+EESILQSDKALT
Sbjct: 438 RGIFSVPGGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDKALT 497
Query: 483 AGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERERENYM 542
AGEKAIAA++A KEAAEKEQELLR+KQKEQQQMMEAQERSFQE +AQ++KK+E EREN +
Sbjct: 498 AGEKAIAAERAMKEAAEKEQELLREKQKEQQQMMEAQERSFQEYMAQMEKKLEEERENLL 557
Query: 543 RELRKMLSHKMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENEEPSVFSQILDVAGS 602
RE ++L HK+KV EE+L E F++ E LN+EIN+LKE+IE+ +NE+ + +ILD+A +
Sbjct: 558 REHERLLKHKLKVQEEMLKEEFQKKSEQLNKEINQLKEKIESTKNEQLRLL-KILDMASN 616
Query: 603 IFIAALPGAAKLVDLGMKILSS 624
I I LPGA+KL+ +G K L S
Sbjct: 617 IMIVTLPGASKLLGVGTKYLGS 638
>gi|157671915 guanylate binding protein family, member 6 [Homo
sapiens]
Length = 633
Score = 868 bits (2244), Expect = 0.0
Identities = 437/632 (69%), Positives = 515/632 (81%)
Query: 1 MASEIHMPGPVCLTENTKGHLVVNSEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAG 60
M S M PVCL EN L+VN +A++IL I+QPVVVVAIVGLYRTGKSYLMN LAG
Sbjct: 1 MESGPKMLAPVCLVENNNEQLLVNQQAIQILEKISQPVVVVAIVGLYRTGKSYLMNHLAG 60
Query: 61 KNKGFPLGCTVKSETKGIWMWCVPHPSKPNHTLILLDTEGLGDMEKSDPKSDSWIFALAV 120
+N GFPLG TV+SETKGIWMWCVPHPSKPNHTL+LLDTEGLGD+EK DPK+DSWIFALAV
Sbjct: 61 QNHGFPLGSTVQSETKGIWMWCVPHPSKPNHTLVLLDTEGLGDVEKGDPKNDSWIFALAV 120
Query: 121 LLSSSFVYNSMGTINHQALEQLHYVTELTELIRAKSCPRPDEVEDSSEFVSFFPDFIWTV 180
LL S+FVYNSM TINHQALEQLHYVTELTELI+AKS PRPD VEDS+EFVSFFPDF+WTV
Sbjct: 121 LLCSTFVYNSMSTINHQALEQLHYVTELTELIKAKSSPRPDGVEDSTEFVSFFPDFLWTV 180
Query: 181 RDFTLELKLDGHPITEDEYLENALKLISGKNPQIQNSNKPREWIRHFFPKQKCFVFDRPI 240
RDFTLELKL+GHPITEDEYLENALKLI G NP++Q SN PRE IR FFPK+KCFVFDRP
Sbjct: 181 RDFTLELKLNGHPITEDEYLENALKLIQGNNPRVQTSNFPRECIRRFFPKRKCFVFDRPT 240
Query: 241 NDKKLLLHVEEVREDQLDSNFQMQSENFCSYIFTHAKTKTLREGILVTGNRLGMLVETYL 300
NDK LL ++E+V E QLD FQ Q+ FCSYIFTHA+TKTLREGI VTGNRLG L TY+
Sbjct: 241 NDKDLLANIEKVSEKQLDPKFQEQTNIFCSYIFTHARTKTLREGITVTGNRLGTLAVTYV 300
Query: 301 DAINSGATPCLENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCE 360
+AINSGA PCLENA+ LAQ ENSAAVQRAA++YSQQMAQ+V+ PTDTLQELLD+HA CE
Sbjct: 301 EAINSGAVPCLENAVITLAQRENSAAVQRAADYYSQQMAQRVKLPTDTLQELLDMHAACE 360
Query: 361 REAIAVFMEYSFKDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLTES 420
REAIA+FME+SFKD++QEFQKK ++T KK DF+LQNEE+S +YCQA+L LS+ L ES
Sbjct: 361 REAIAIFMEHSFKDENQEFQKKFMETTMNKKGDFLLQNEESSVQYCQAKLNELSKGLMES 420
Query: 421 ISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKA 480
IS G+F VPGGH +Y+E K++IEQDY VPRKGVKA EV Q FL+SQ+VIEESILQSDKA
Sbjct: 421 ISAGSFSVPGGHKLYMETKERIEQDYWQVPRKGVKAKEVFQRFLESQMVIEESILQSDKA 480
Query: 481 LTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMEREREN 540
LT EKA+A +AKKEAAEKEQELL+QK +EQQQ MEAQ++S +ENIAQLK+K++ ERE+
Sbjct: 481 LTDREKAVAVDRAKKEAAEKEQELLKQKLQEQQQQMEAQDKSRKENIAQLKEKLQMEREH 540
Query: 541 YMRELRKMLSHKMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENEEPSVFSQILDVA 600
+RE ML H KV + L EGFK+ +E +N EI++ K I+ +N++ ++ LD
Sbjct: 541 LLREQIMMLEHTQKVQNDWLHEGFKKKYEEMNAEISQFKRMIDTTKNDDTPWIARTLDNL 600
Query: 601 GSIFIAALPGAAKLVDLGMKILSSLCNRLRNP 632
A L AKL+ G+K +SSL + + P
Sbjct: 601 ADELTAILSAPAKLIGHGVKGVSSLFKKHKLP 632
>gi|38327558 guanylate binding protein 2, interferon-inducible [Homo
sapiens]
Length = 591
Score = 650 bits (1677), Expect = 0.0
Identities = 326/575 (56%), Positives = 435/575 (75%), Gaps = 1/575 (0%)
Query: 1 MASEIHMPGPVCLTENTKGHLVVNSEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAG 60
MA EI++PGP+ L +NTKG LVVN EAL+ILSAITQPVVVVAIVGLYRTGKSYLMNKLAG
Sbjct: 1 MAPEINLPGPMSLIDNTKGQLVVNPEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAG 60
Query: 61 KNKGFPLGCTVKSETKGIWMWCVPHPSKPNHTLILLDTEGLGDMEKSDPKSDSWIFALAV 120
K GF LG TVKS TKGIWMWCVPHP KP HTL+LLDTEGLGD+EK D ++DSWIFALA+
Sbjct: 61 KKNGFSLGSTVKSHTKGIWMWCVPHPKKPEHTLVLLDTEGLGDIEKGDNENDSWIFALAI 120
Query: 121 LLSSSFVYNSMGTINHQALEQLHYVTELTELIRAKSCPRPDEVEDSSEFVSFFPDFIWTV 180
LLSS+FVYNSMGTIN QA++QLHYVTELT+ I+A S P + V+DS++FVSFFP F+WT+
Sbjct: 121 LLSSTFVYNSMGTINQQAMDQLHYVTELTDRIKANSSPGNNSVDDSADFVSFFPAFVWTL 180
Query: 181 RDFTLELKLDGHPITEDEYLENALKLISGKNPQIQNSNKPREWIRHFFPKQKCFVFDRPI 240
RDFTLEL++DG PIT D+YLE +LKL G + + ++ N PR IR FFPK+KCFVFD P
Sbjct: 181 RDFTLELEVDGEPITADDYLELSLKLRKGTDKKSKSFNDPRLCIRKFFPKRKCFVFDWPA 240
Query: 241 NDKKLLLHVEEVREDQLDSNFQMQSENFCSYIFTHAKTKTLREGILVTGNRLGMLVETYL 300
KK L H+E+++E++L+ +F Q FCSYI +H+ KTL GI V G RL LV TY+
Sbjct: 241 -PKKYLAHLEQLKEEELNPDFIEQVAEFCSYILSHSNVKTLSGGIPVNGPRLESLVLTYV 299
Query: 301 DAINSGATPCLENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCE 360
+AI+SG PC+ENA+ LAQ ENSAAV++A HY QQM Q+V+ PT+TLQELLD+H E
Sbjct: 300 NAISSGDLPCMENAVLALAQIENSAAVEKAIAHYEQQMGQKVQLPTETLQELLDLHRDSE 359
Query: 361 REAIAVFMEYSFKDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLTES 420
REAI VFM+ SFKD Q FQ+KL +E +++DF QN +AS+ C A L+ + L E
Sbjct: 360 REAIEVFMKNSFKDVDQMFQRKLGAQLEARRDDFCKQNSKASSDCCMALLQDIFGPLEED 419
Query: 421 ISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKA 480
+ +GTF PGG+ ++ + ++++ Y VPRKG++A EVL+ +L+S+ + +++LQ+D++
Sbjct: 420 VKQGTFSKPGGYRLFTQKLQELKNKYYQVPRKGIQAKEVLKKYLESKEDVADALLQTDQS 479
Query: 481 LTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMEREREN 540
L+ EKAI ++ K E+AE +++L + QK+ ++MME +E+S+QE++ QL +KMER+R
Sbjct: 480 LSEKEKAIEVERIKAESAEAAKKMLEEIQKKNEEMMEQKEKSYQEHVKQLTEKMERDRAQ 539
Query: 541 YMRELRKMLSHKMKVLEELLTEGFKEIFESLNEEI 575
M E K L+ K++ E LL EGF+ + L ++I
Sbjct: 540 LMAEQEKTLALKLQEQERLLKEGFENESKRLQKDI 574
>gi|166706903 guanylate binding protein 1, interferon-inducible,
67kDa [Homo sapiens]
Length = 592
Score = 649 bits (1673), Expect = 0.0
Identities = 324/584 (55%), Positives = 440/584 (75%), Gaps = 3/584 (0%)
Query: 1 MASEIHMPGPVCLTENTKGHLVVNSEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAG 60
MASEIHM GP+CL ENT G L+ N EAL+ILSAITQP+VVVAIVGLYRTGKSYLMNKLAG
Sbjct: 1 MASEIHMTGPMCLIENTNGRLMANPEALKILSAITQPMVVVAIVGLYRTGKSYLMNKLAG 60
Query: 61 KNKGFPLGCTVKSETKGIWMWCVPHPSKPNHTLILLDTEGLGDMEKSDPKSDSWIFALAV 120
K KGF LG TV+S TKGIWMWCVPHP KP H L+LLDTEGLGD+EK D ++DSWIFALAV
Sbjct: 61 KKKGFSLGSTVQSHTKGIWMWCVPHPKKPGHILVLLDTEGLGDVEKGDNQNDSWIFALAV 120
Query: 121 LLSSSFVYNSMGTINHQALEQLHYVTELTELIRAKSCP--RPDEVEDSSEFVSFFPDFIW 178
LLSS+FVYNS+GTIN QA++QL+YVTELT IR+KS P +EVEDS++FVSFFPDF+W
Sbjct: 121 LLSSTFVYNSIGTINQQAMDQLYYVTELTHRIRSKSSPDENENEVEDSADFVSFFPDFVW 180
Query: 179 TVRDFTLELKLDGHPITEDEYLENALKLISGKNPQIQNSNKPREWIRHFFPKQKCFVFDR 238
T+RDF+L+L+ DG P+T DEYL +LKL G + + + N PR IR FFPK+KCFVFDR
Sbjct: 181 TLRDFSLDLEADGQPLTPDEYLTYSLKLKKGTSQKDETFNLPRLCIRKFFPKKKCFVFDR 240
Query: 239 PINDKKLLLHVEEVREDQLDSNFQMQSENFCSYIFTHAKTKTLREGILVTGNRLGMLVET 298
P++ +KL +E++++++LD F Q +FCSYIF+++KTKTL GI V G RL LV T
Sbjct: 241 PVHRRKLA-QLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIQVNGPRLESLVLT 299
Query: 299 YLDAINSGATPCLENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAV 358
Y++AI+SG PC+ENA+ LAQ ENSAAVQ+A HY QQM Q+V+ PT+TLQELLD+H
Sbjct: 300 YVNAISSGDLPCMENAVLALAQIENSAAVQKAIAHYEQQMGQKVQLPTETLQELLDLHRD 359
Query: 359 CEREAIAVFMEYSFKDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLT 418
EREAI VF+ SFKD FQK+L +EKK++DF QN+EAS+ C A L+ + L
Sbjct: 360 SEREAIEVFIRSSFKDVDHLFQKELAAQLEKKRDDFCKQNQEASSDRCSALLQVIFSPLE 419
Query: 419 ESISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSD 478
E + G + PGG+ ++++ + +++ Y PRKG++A+E+LQ++L+S+ + ++ILQ+D
Sbjct: 420 EEVKAGIYSKPGGYRLFVQKLQDLKKKYYEEPRKGIQAEEILQTYLKSKESMTDAILQTD 479
Query: 479 KALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERER 538
+ LT EK I ++ K E+A+ ++L++ Q++ +QMME +ERS+QE++ QL +KME +R
Sbjct: 480 QTLTEKEKEIEVERVKAESAQASAKMLQEMQRKNEQMMEQKERSYQEHLKQLTEKMENDR 539
Query: 539 ENYMRELRKMLSHKMKVLEELLTEGFKEIFESLNEEINRLKEQI 582
++E + L+ K++ E+LL EGF++ + EI L+ ++
Sbjct: 540 VQLLKEQERTLALKLQEQEQLLKEGFQKESRIMKNEIQDLQTKM 583
>gi|112382372 guanylate binding protein 3 [Homo sapiens]
Length = 595
Score = 647 bits (1668), Expect = 0.0
Identities = 325/583 (55%), Positives = 432/583 (74%), Gaps = 1/583 (0%)
Query: 1 MASEIHMPGPVCLTENTKGHLVVNSEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAG 60
MA EIHM GP+CL ENT G LV N EAL+ILSAITQPVVVVAIVGLYRTGKSYLMNKLAG
Sbjct: 1 MAPEIHMTGPMCLIENTNGELVANPEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAG 60
Query: 61 KNKGFPLGCTVKSETKGIWMWCVPHPSKPNHTLILLDTEGLGDMEKSDPKSDSWIFALAV 120
KNKGF LG TVKS TKGIWMWCVPHP KP HTL+LLDTEGLGD++K D ++DSWIF LAV
Sbjct: 61 KNKGFSLGSTVKSHTKGIWMWCVPHPKKPEHTLVLLDTEGLGDVKKGDNQNDSWIFTLAV 120
Query: 121 LLSSSFVYNSMGTINHQALEQLHYVTELTELIRAKSCPRPDEVEDSSEFVSFFPDFIWTV 180
LLSS+ VYNSMGTIN QA++QL+YVTELT IR+KS P +E EDS++FVSFFPDF+WT+
Sbjct: 121 LLSSTLVYNSMGTINQQAMDQLYYVTELTHRIRSKSSPDENENEDSADFVSFFPDFVWTL 180
Query: 181 RDFTLELKLDGHPITEDEYLENALKLISGKNPQIQNSNKPREWIRHFFPKQKCFVFDRPI 240
RDF+L+L+ DG P+T DEYLE +LKL G + + +N N PR IR FFPK+KCFVFD PI
Sbjct: 181 RDFSLDLEADGQPLTPDEYLEYSLKLTQGTSQKDKNFNLPRLCIRKFFPKKKCFVFDLPI 240
Query: 241 NDKKLLLHVEEVREDQLDSNFQMQSENFCSYIFTHAKTKTLREGILVTGNRLGMLVETYL 300
+ +K L +E++++++LD F Q +FCSYIF+++KTKTL GI V G RL LV TY+
Sbjct: 241 HRRK-LAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIKVNGPRLESLVLTYI 299
Query: 301 DAINSGATPCLENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCE 360
+AI+ G PC+ENA+ LAQ ENSAAVQ+A HY QQM Q+V+ P +TLQELLD+H V E
Sbjct: 300 NAISRGDLPCMENAVLALAQIENSAAVQKAIAHYDQQMGQKVQLPAETLQELLDLHRVSE 359
Query: 361 REAIAVFMEYSFKDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLTES 420
REA V+M+ SFKD FQKKL ++KK++DF QN+EAS+ C A L+ + L E
Sbjct: 360 REATEVYMKNSFKDVDHLFQKKLAAQLDKKRDDFCKQNQEASSDRCSALLQVIFSPLEEE 419
Query: 421 ISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKA 480
+ G + PGG+ ++++ + +E+ Y PRKG++A+E+LQ++L+S+ + ++ILQ+D+
Sbjct: 420 VKAGIYSKPGGYCLFIQKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQI 479
Query: 481 LTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMEREREN 540
LT EK I + K E+A+ +++ + Q + QQMME +E+S+QE++ QL +KMERER
Sbjct: 480 LTEKEKEIEVECVKAESAQASAKMVEEMQIKYQQMMEEKEKSYQEHVKQLTEKMERERAQ 539
Query: 541 YMRELRKMLSHKMKVLEELLTEGFKEIFESLNEEINRLKEQIE 583
+ E K L+ K++ +L E + L EI +L++ ++
Sbjct: 540 LLEEQEKTLTSKLQEQARVLKERCQGESTQLQNEIQKLQKTLK 582
>gi|197333737 guanylate-binding protein 5 [Homo sapiens]
Length = 586
Score = 593 bits (1529), Expect = e-169
Identities = 307/592 (51%), Positives = 415/592 (70%), Gaps = 8/592 (1%)
Query: 1 MASEIHMPGPVCLTENTKGHLVVNSEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAG 60
MA EIHM P+CL EN L VN EALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAG
Sbjct: 1 MALEIHMSDPMCLIENFNEQLKVNQEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAG 60
Query: 61 KNKGFPLGCTVKSETKGIWMWCVPHPSKPNHTLILLDTEGLGDMEKSDPKSDSWIFALAV 120
KNKGF + TV+S TKGIW+WCVPHP+ PNHTL+LLDTEGLGD+EK+D K+D IFALA+
Sbjct: 61 KNKGFSVASTVQSHTKGIWIWCVPHPNWPNHTLVLLDTEGLGDVEKADNKNDIQIFALAL 120
Query: 121 LLSSSFVYNSMGTINHQALEQLHYVTELTELIRAKSCPRPDEVEDSSEFVSFFPDFIWTV 180
LLSS+FVYN++ I+ A++ LH VTELT+L++A++ P D VED ++ SFFPD +WT+
Sbjct: 121 LLSSTFVYNTVNKIDQGAIDLLHNVTELTDLLKARNSPDLDRVEDPADSASFFPDLVWTL 180
Query: 181 RDFTLELKLDGHPITEDEYLENALKLISGKNPQIQNSNKPREWIRHFFPKQKCFVFDRPI 240
RDF L L++DG +T DEYLEN+L+ G + ++QN N PR I+ FFPK+KCF+FD P
Sbjct: 181 RDFCLGLEIDGQLVTPDEYLENSLRPKQGSDQRVQNFNLPRLCIQKFFPKKKCFIFDLPA 240
Query: 241 NDKKLLLHVEEVREDQLDSNFQMQSENFCSYIFTHAKTKTLREGILVTGNRLGMLVETYL 300
+ KK L +E + +D+L+ F Q FCSYIF+H+ TKTL GI+V G+RL LV TY+
Sbjct: 241 HQKK-LAQLETLPDDELEPEFVQQVTEFCSYIFSHSMTKTLPGGIMVNGSRLKNLVLTYV 299
Query: 301 DAINSGATPCLENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCE 360
+AI+SG PC+ENA+ LAQ ENSAAVQ+A HY QQM Q+V+ P +TLQELLD+H E
Sbjct: 300 NAISSGDLPCIENAVLALAQRENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSE 359
Query: 361 REAIAVFMEYSFKDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLTES 420
REAI VFM+ SFKD Q FQK+L ++ K+ D +N EAS+ YC A LK + L E+
Sbjct: 360 REAIEVFMKNSFKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSALLKDIFGPLEEA 419
Query: 421 ISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKA 480
+ +G + PGGHN++++ ++++ Y PRKG++A+EVLQ +L+S+ + +ILQ+D+A
Sbjct: 420 VKQGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQA 479
Query: 481 LTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMEREREN 540
LT EK Q K EA + E + L Q++ +QMM+ +ER QE + Q ME ++N
Sbjct: 480 LTETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERERLHQEQVRQ----MEIAKQN 535
Query: 541 YMRELRKMLSHKMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENEEPSV 592
++ E +KM +M+ L+ F+ SL E+ + + N++P V
Sbjct: 536 WLAEQQKMQEQQMQEQAAQLSTTFQAQNRSLLSELQHAQRTV---NNDDPCV 584
>gi|16418425 guanylate-binding protein 5 [Homo sapiens]
Length = 586
Score = 593 bits (1529), Expect = e-169
Identities = 307/592 (51%), Positives = 415/592 (70%), Gaps = 8/592 (1%)
Query: 1 MASEIHMPGPVCLTENTKGHLVVNSEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAG 60
MA EIHM P+CL EN L VN EALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAG
Sbjct: 1 MALEIHMSDPMCLIENFNEQLKVNQEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAG 60
Query: 61 KNKGFPLGCTVKSETKGIWMWCVPHPSKPNHTLILLDTEGLGDMEKSDPKSDSWIFALAV 120
KNKGF + TV+S TKGIW+WCVPHP+ PNHTL+LLDTEGLGD+EK+D K+D IFALA+
Sbjct: 61 KNKGFSVASTVQSHTKGIWIWCVPHPNWPNHTLVLLDTEGLGDVEKADNKNDIQIFALAL 120
Query: 121 LLSSSFVYNSMGTINHQALEQLHYVTELTELIRAKSCPRPDEVEDSSEFVSFFPDFIWTV 180
LLSS+FVYN++ I+ A++ LH VTELT+L++A++ P D VED ++ SFFPD +WT+
Sbjct: 121 LLSSTFVYNTVNKIDQGAIDLLHNVTELTDLLKARNSPDLDRVEDPADSASFFPDLVWTL 180
Query: 181 RDFTLELKLDGHPITEDEYLENALKLISGKNPQIQNSNKPREWIRHFFPKQKCFVFDRPI 240
RDF L L++DG +T DEYLEN+L+ G + ++QN N PR I+ FFPK+KCF+FD P
Sbjct: 181 RDFCLGLEIDGQLVTPDEYLENSLRPKQGSDQRVQNFNLPRLCIQKFFPKKKCFIFDLPA 240
Query: 241 NDKKLLLHVEEVREDQLDSNFQMQSENFCSYIFTHAKTKTLREGILVTGNRLGMLVETYL 300
+ KK L +E + +D+L+ F Q FCSYIF+H+ TKTL GI+V G+RL LV TY+
Sbjct: 241 HQKK-LAQLETLPDDELEPEFVQQVTEFCSYIFSHSMTKTLPGGIMVNGSRLKNLVLTYV 299
Query: 301 DAINSGATPCLENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCE 360
+AI+SG PC+ENA+ LAQ ENSAAVQ+A HY QQM Q+V+ P +TLQELLD+H E
Sbjct: 300 NAISSGDLPCIENAVLALAQRENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSE 359
Query: 361 REAIAVFMEYSFKDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLTES 420
REAI VFM+ SFKD Q FQK+L ++ K+ D +N EAS+ YC A LK + L E+
Sbjct: 360 REAIEVFMKNSFKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSALLKDIFGPLEEA 419
Query: 421 ISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKA 480
+ +G + PGGHN++++ ++++ Y PRKG++A+EVLQ +L+S+ + +ILQ+D+A
Sbjct: 420 VKQGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQA 479
Query: 481 LTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMEREREN 540
LT EK Q K EA + E + L Q++ +QMM+ +ER QE + Q ME ++N
Sbjct: 480 LTETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERERLHQEQVRQ----MEIAKQN 535
Query: 541 YMRELRKMLSHKMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENEEPSV 592
++ E +KM +M+ L+ F+ SL E+ + + N++P V
Sbjct: 536 WLAEQQKMQEQQMQEQAAQLSTTFQAQNRSLLSELQHAQRTV---NNDDPCV 584
>gi|169160863 PREDICTED: similar to guanylate-binding protein 5
[Homo sapiens]
Length = 112
Score = 102 bits (253), Expect = 1e-21
Identities = 51/67 (76%), Positives = 60/67 (89%), Gaps = 1/67 (1%)
Query: 318 LAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCEREAIAVFMEYSFKDKSQ 377
LAQ ENS A+QRAANHYSQQMAQ++RFPTD LQELLD+H CEREAIAVFME+S + ++Q
Sbjct: 3 LAQRENSVALQRAANHYSQQMAQRMRFPTDMLQELLDMHTACEREAIAVFMEHS-RGENQ 61
Query: 378 EFQKKLV 384
EFQKKL+
Sbjct: 62 EFQKKLM 68
>gi|208610002 atlastin GTPase 2 isoform 2 [Homo sapiens]
Length = 583
Score = 72.8 bits (177), Expect = 9e-13
Identities = 89/395 (22%), Positives = 163/395 (41%), Gaps = 45/395 (11%)
Query: 38 VVVVAIVGLYRTGKSYLM--------NK-----LAGKNK---GFPLGCTVKSETKGIWMW 81
+VVV++ G +R GKS+L+ NK + G N+ GF + ET GI +W
Sbjct: 94 IVVVSVAGAFRKGKSFLLDFMLRYMYNKDSQSWIGGNNEPLTGFTWRGGCERETTGIQVW 153
Query: 82 ----CVPHPSKPNHTLILLDTEGLGDMEKSDPKSDSWIFALAVLLSSSFVYNSMGTINHQ 137
+ P+ ++L+DT+G D + S K + +FAL+ + SS VYN I
Sbjct: 154 NEVFVIDRPNGTKVAVLLMDTQGAFDSQ-STIKDCATVFALSTMTSSVQVYNLSQNIQED 212
Query: 138 ALEQLHYVTELTELIRAKSCPRPDEVEDSSEFVSFFPDFIWTVRDFTLELKLDGHPITED 197
L+ L TE L + +P F ++ +RD++ +
Sbjct: 213 DLQHLQLFTEYGRLAMEEIYQKP------------FQTLMFLIRDWSYPYEHSYGLEGGK 260
Query: 198 EYLENALKLISGKNPQIQNSNKPREWIRHFFPKQKCFVFDRPINDKKLLLHVEEVREDQL 257
++LE L++ ++ ++QN R+ I + F CF+ P K + R +
Sbjct: 261 QFLEKRLQVKQNQHEELQN---VRKHIHNCFSNLGCFLLPHP-GLKVATNPSFDGRLKDI 316
Query: 258 DSNFQMQSENFCSYIFTHAK-TKTLREGILVTGNRLGMLVETYLDAINSGATPCLENAMA 316
D +F+ + N + + G VT L + Y+ P ++ +
Sbjct: 317 DEDFKRELRNLVPLLLAPENLVEKEISGSKVTCRDLVEYFKAYIKIYQGEELPHPKSMLQ 376
Query: 317 VLAQCENSAAVQRAANHYSQQMAQ------QVRFPTDTLQELLDVHAVCEREAIAVFMEY 370
A+ N AAV A + Y + M Q P+D ++ LD+ V ++ +V +
Sbjct: 377 ATAEANNLAAVAGARDTYCKSMEQVCGGDKPYIAPSDLERKHLDLKEVAIKQFRSV-KKM 435
Query: 371 SFKDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKY 405
+ + +Q +L +E+ +F+ N+ + Y
Sbjct: 436 GGDEFCRRYQDQLEAEIEETYANFIKHNDGKNIFY 470
>gi|208610000 atlastin GTPase 2 isoform 1 [Homo sapiens]
Length = 579
Score = 72.8 bits (177), Expect = 9e-13
Identities = 89/395 (22%), Positives = 163/395 (41%), Gaps = 45/395 (11%)
Query: 38 VVVVAIVGLYRTGKSYLM--------NK-----LAGKNK---GFPLGCTVKSETKGIWMW 81
+VVV++ G +R GKS+L+ NK + G N+ GF + ET GI +W
Sbjct: 94 IVVVSVAGAFRKGKSFLLDFMLRYMYNKDSQSWIGGNNEPLTGFTWRGGCERETTGIQVW 153
Query: 82 ----CVPHPSKPNHTLILLDTEGLGDMEKSDPKSDSWIFALAVLLSSSFVYNSMGTINHQ 137
+ P+ ++L+DT+G D + S K + +FAL+ + SS VYN I
Sbjct: 154 NEVFVIDRPNGTKVAVLLMDTQGAFDSQ-STIKDCATVFALSTMTSSVQVYNLSQNIQED 212
Query: 138 ALEQLHYVTELTELIRAKSCPRPDEVEDSSEFVSFFPDFIWTVRDFTLELKLDGHPITED 197
L+ L TE L + +P F ++ +RD++ +
Sbjct: 213 DLQHLQLFTEYGRLAMEEIYQKP------------FQTLMFLIRDWSYPYEHSYGLEGGK 260
Query: 198 EYLENALKLISGKNPQIQNSNKPREWIRHFFPKQKCFVFDRPINDKKLLLHVEEVREDQL 257
++LE L++ ++ ++QN R+ I + F CF+ P K + R +
Sbjct: 261 QFLEKRLQVKQNQHEELQN---VRKHIHNCFSNLGCFLLPHP-GLKVATNPSFDGRLKDI 316
Query: 258 DSNFQMQSENFCSYIFTHAK-TKTLREGILVTGNRLGMLVETYLDAINSGATPCLENAMA 316
D +F+ + N + + G VT L + Y+ P ++ +
Sbjct: 317 DEDFKRELRNLVPLLLAPENLVEKEISGSKVTCRDLVEYFKAYIKIYQGEELPHPKSMLQ 376
Query: 317 VLAQCENSAAVQRAANHYSQQMAQ------QVRFPTDTLQELLDVHAVCEREAIAVFMEY 370
A+ N AAV A + Y + M Q P+D ++ LD+ V ++ +V +
Sbjct: 377 ATAEANNLAAVAGARDTYCKSMEQVCGGDKPYIAPSDLERKHLDLKEVAIKQFRSV-KKM 435
Query: 371 SFKDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKY 405
+ + +Q +L +E+ +F+ N+ + Y
Sbjct: 436 GGDEFCRRYQDQLEAEIEETYANFIKHNDGKNIFY 470
>gi|189181742 atlastin GTPase 1 isoform b [Homo sapiens]
Length = 553
Score = 71.2 bits (173), Expect = 3e-12
Identities = 83/385 (21%), Positives = 162/385 (42%), Gaps = 45/385 (11%)
Query: 38 VVVVAIVGLYRTGKSYLMNKL-------------AGKNK---GFPLGCTVKSETKGIWMW 81
VV V++ G +R GKS+LM+ + N+ GF + ET GI +W
Sbjct: 67 VVAVSVAGAFRKGKSFLMDFMLRYMYNQESVDWVGDYNEPLTGFSWRGGSERETTGIQIW 126
Query: 82 C----VPHPSKPNHTLILLDTEGLGDMEKSDPKSDSWIFALAVLLSSSFVYNSMGTINHQ 137
+ P ++L+DT+G D + S + + +FAL+ ++SS VYN +
Sbjct: 127 SEIFLINKPDGKKVAVLLMDTQGTFDSQ-STLRDSATVFALSTMISSIQVYNLSQNVQED 185
Query: 138 ALEQLHYVTELTELIRAKSCPRPDEVEDSSEFVSFFPDFIWTVRDFTLELKLDGHPITED 197
L+ L TE L ++ +P F I+ VRD++ +
Sbjct: 186 DLQHLQLFTEYGRLAMEETFLKP------------FQSLIFLVRDWSFPYEFSYGADGGA 233
Query: 198 EYLENALKLISGKNPQIQNSNKPREWIRHFFPKQKCFVFDRPINDKKLLLHVE-EVREDQ 256
++LE LK+ ++ ++QN R+ I F CF+ P K+ + + + +
Sbjct: 234 KFLEKRLKVSGNQHEELQN---VRKHIHSCFTNISCFLLPHP--GLKVATNPNFDGKLKE 288
Query: 257 LDSNFQMQSENFCSYIFTHAKTKTLRE--GILVTGNRLGMLVETYLDAINSGATPCLENA 314
+D F + ++ + ++ ++E G +T L + Y+ P ++
Sbjct: 289 IDDEFIKNLKILIPWLLS-PESLDIKEINGNKITCRGLVEYFKAYIKIYQGEELPHPKSM 347
Query: 315 MAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTL--QELLDVHAVCEREAIAVFMEYSF 372
+ A+ N AAV A + Y+++M + L +L H + E++ +F
Sbjct: 348 LQATAEANNLAAVATAKDTYNKKMEEICGGDKPFLAPNDLQTKHLQLKEESVKLFRGVK- 406
Query: 373 KDKSQEFQKKLVDTMEKKKEDFVLQ 397
K +EF ++ + +E + ++ +Q
Sbjct: 407 KMGGEEFSRRYLQQLESEIDELYIQ 431
>gi|74024917 atlastin GTPase 1 isoform b [Homo sapiens]
Length = 553
Score = 71.2 bits (173), Expect = 3e-12
Identities = 83/385 (21%), Positives = 162/385 (42%), Gaps = 45/385 (11%)
Query: 38 VVVVAIVGLYRTGKSYLMNKL-------------AGKNK---GFPLGCTVKSETKGIWMW 81
VV V++ G +R GKS+LM+ + N+ GF + ET GI +W
Sbjct: 67 VVAVSVAGAFRKGKSFLMDFMLRYMYNQESVDWVGDYNEPLTGFSWRGGSERETTGIQIW 126
Query: 82 C----VPHPSKPNHTLILLDTEGLGDMEKSDPKSDSWIFALAVLLSSSFVYNSMGTINHQ 137
+ P ++L+DT+G D + S + + +FAL+ ++SS VYN +
Sbjct: 127 SEIFLINKPDGKKVAVLLMDTQGTFDSQ-STLRDSATVFALSTMISSIQVYNLSQNVQED 185
Query: 138 ALEQLHYVTELTELIRAKSCPRPDEVEDSSEFVSFFPDFIWTVRDFTLELKLDGHPITED 197
L+ L TE L ++ +P F I+ VRD++ +
Sbjct: 186 DLQHLQLFTEYGRLAMEETFLKP------------FQSLIFLVRDWSFPYEFSYGADGGA 233
Query: 198 EYLENALKLISGKNPQIQNSNKPREWIRHFFPKQKCFVFDRPINDKKLLLHVE-EVREDQ 256
++LE LK+ ++ ++QN R+ I F CF+ P K+ + + + +
Sbjct: 234 KFLEKRLKVSGNQHEELQN---VRKHIHSCFTNISCFLLPHP--GLKVATNPNFDGKLKE 288
Query: 257 LDSNFQMQSENFCSYIFTHAKTKTLRE--GILVTGNRLGMLVETYLDAINSGATPCLENA 314
+D F + ++ + ++ ++E G +T L + Y+ P ++
Sbjct: 289 IDDEFIKNLKILIPWLLS-PESLDIKEINGNKITCRGLVEYFKAYIKIYQGEELPHPKSM 347
Query: 315 MAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTL--QELLDVHAVCEREAIAVFMEYSF 372
+ A+ N AAV A + Y+++M + L +L H + E++ +F
Sbjct: 348 LQATAEANNLAAVATAKDTYNKKMEEICGGDKPFLAPNDLQTKHLQLKEESVKLFRGVK- 406
Query: 373 KDKSQEFQKKLVDTMEKKKEDFVLQ 397
K +EF ++ + +E + ++ +Q
Sbjct: 407 KMGGEEFSRRYLQQLESEIDELYIQ 431
>gi|19923445 atlastin GTPase 1 isoform a [Homo sapiens]
Length = 558
Score = 71.2 bits (173), Expect = 3e-12
Identities = 83/385 (21%), Positives = 162/385 (42%), Gaps = 45/385 (11%)
Query: 38 VVVVAIVGLYRTGKSYLMNKL-------------AGKNK---GFPLGCTVKSETKGIWMW 81
VV V++ G +R GKS+LM+ + N+ GF + ET GI +W
Sbjct: 67 VVAVSVAGAFRKGKSFLMDFMLRYMYNQESVDWVGDYNEPLTGFSWRGGSERETTGIQIW 126
Query: 82 C----VPHPSKPNHTLILLDTEGLGDMEKSDPKSDSWIFALAVLLSSSFVYNSMGTINHQ 137
+ P ++L+DT+G D + S + + +FAL+ ++SS VYN +
Sbjct: 127 SEIFLINKPDGKKVAVLLMDTQGTFDSQ-STLRDSATVFALSTMISSIQVYNLSQNVQED 185
Query: 138 ALEQLHYVTELTELIRAKSCPRPDEVEDSSEFVSFFPDFIWTVRDFTLELKLDGHPITED 197
L+ L TE L ++ +P F I+ VRD++ +
Sbjct: 186 DLQHLQLFTEYGRLAMEETFLKP------------FQSLIFLVRDWSFPYEFSYGADGGA 233
Query: 198 EYLENALKLISGKNPQIQNSNKPREWIRHFFPKQKCFVFDRPINDKKLLLHVE-EVREDQ 256
++LE LK+ ++ ++QN R+ I F CF+ P K+ + + + +
Sbjct: 234 KFLEKRLKVSGNQHEELQN---VRKHIHSCFTNISCFLLPHP--GLKVATNPNFDGKLKE 288
Query: 257 LDSNFQMQSENFCSYIFTHAKTKTLRE--GILVTGNRLGMLVETYLDAINSGATPCLENA 314
+D F + ++ + ++ ++E G +T L + Y+ P ++
Sbjct: 289 IDDEFIKNLKILIPWLLS-PESLDIKEINGNKITCRGLVEYFKAYIKIYQGEELPHPKSM 347
Query: 315 MAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTL--QELLDVHAVCEREAIAVFMEYSF 372
+ A+ N AAV A + Y+++M + L +L H + E++ +F
Sbjct: 348 LQATAEANNLAAVATAKDTYNKKMEEICGGDKPFLAPNDLQTKHLQLKEESVKLFRGVK- 406
Query: 373 KDKSQEFQKKLVDTMEKKKEDFVLQ 397
K +EF ++ + +E + ++ +Q
Sbjct: 407 KMGGEEFSRRYLQQLESEIDELYIQ 431
>gi|45827806 atlastin 3 [Homo sapiens]
Length = 541
Score = 66.6 bits (161), Expect = 7e-11
Identities = 99/432 (22%), Positives = 165/432 (38%), Gaps = 52/432 (12%)
Query: 2 ASEIHMPGPVCLTENTKGHLVVNSEALEILSAITQP------VVVVAIVGLYRTGKSYLM 55
A E PGPV + K + + S + Q VVVV++ G +R GKS+++
Sbjct: 18 AMESSKPGPVQVVLVQKDQHSFELDEKALASILLQDHIRDLDVVVVSVAGAFRKGKSFIL 77
Query: 56 N---------KLAGKNK----------GFPLGCTVKSETKGIWMWC----VPHPSKPNHT 92
+ K +G + GF ET GI +W V P
Sbjct: 78 DFMLRYLYSQKESGHSNWLGDPEEPLTGFSWRGGSDPETTGIQIWSEVFTVEKPGGKKVA 137
Query: 93 LILLDTEGLGDMEKSDPKSDSWIFALAVLLSSSFVYNSMGTINHQALEQLHYVTELTELI 152
++L+DT+G D + S K + IFAL+ + SS +YN I L+QL TE L
Sbjct: 138 VVLMDTQGAFDSQ-STVKDCATIFALSTMTSSVQIYNLSQNIQEDDLQQLQLFTEYGRLA 196
Query: 153 RAKSCPRPDEVEDSSEFVSFFPDFIWTVRDFTLELKLDGHPITEDEYLENALKLISGKNP 212
DE+ F F ++ VRD++ + +L+ L++ ++
Sbjct: 197 M-------DEI-----FQKPFQTLMFLVRDWSFPYEYSYGLQGGMAFLDKRLQVKEHQHE 244
Query: 213 QIQNSNKPREWIRHFFPKQKCFVFDRPINDKKLLLHVEEVREDQLDSNFQMQSENFCSYI 272
+IQN R I F CF+ P + +D + F+ Q + Y+
Sbjct: 245 EIQN---VRNHIHSCFSDVTCFLLPHPGLQVATSPDFDGKLKD-IAGEFKEQLQALIPYV 300
Query: 273 FTHAKTKTLR-EGILVTGNRLGMLVETYLDAINSGATPCLENAMAVLAQCENSAAVQRAA 331
+K G VT L + Y+ P ++ + A+ N AA A
Sbjct: 301 LNPSKLMEKEINGSKVTCRGLLEYFKAYIKIYQGEDLPHPKSMLQATAEANNLAAAASAK 360
Query: 332 NHYSQQMAQQVRFPTDTLQELLDVHAVCEREAIAV-----FMEYSFKDKSQEFQKKLVDT 386
+ Y M + L + CE + +A+ + KD S +Q++L +
Sbjct: 361 DIYYNNMEEVCGGEKPYLSPDILEEKHCEFKQLALDHFKKTKKMGGKDFSFRYQQELEEE 420
Query: 387 MEKKKEDFVLQN 398
+++ E+F N
Sbjct: 421 IKELYENFCKHN 432
>gi|58530840 desmoplakin isoform I [Homo sapiens]
Length = 2871
Score = 53.5 bits (127), Expect = 6e-07
Identities = 82/432 (18%), Positives = 181/432 (41%), Gaps = 80/432 (18%)
Query: 200 LENALKLISGKNPQIQN------SNKPREW--------IRHFFPKQKCFV---FDRPIND 242
LE A K I KN +I+ R W +R+ + ++ + F+ IN
Sbjct: 1313 LEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINI 1372
Query: 243 KKLLLHVEEVREDQLDSNFQMQSENFCSYIFTHAKTKTLREGILVTGNRLGMLVETYLDA 302
K +H +++++ S ++ Q +N + ++L E I N L E
Sbjct: 1373 TKTTIHQLTMQKEEDTSGYRAQIDNLTR------ENRSLSEEIKRLKNTLTQTTEN---- 1422
Query: 303 INSGATPCLENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCERE 362
L + E Q+A Q QQ+ + ++ +V ++
Sbjct: 1423 ---------------LRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQ 1467
Query: 363 AIAVFMEYSFKDKSQEFQ--KKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLTES 420
++ + + +DK++E + K+L+D ++ L++E A + Q +L++ + TE+
Sbjct: 1468 SLDDAAK-TIQDKNKEIERLKQLIDKETNDRK--CLEDENARLQRVQYDLQKANSSATET 1524
Query: 421 ISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKA 480
I++ + + ++ DY V ++ D+ + F S ++ + ++
Sbjct: 1525 INK--------LKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEE 1576
Query: 481 LTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQ--------QQMMEAQ--ERSFQENIAQL 530
L ++ + K++ E+E E +R+ KEQ QQ+ +A ++ ++++ Q
Sbjct: 1577 LNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQ 1636
Query: 531 KKKME---RERENYMRELRKMLSH----KMKVLEE--------LLTEGFKEIFESLNEEI 575
+ ++ RE++ ELR++ S + ++L+E L E F++ E + +
Sbjct: 1637 RDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSL 1696
Query: 576 NRLKEQIEAAEN 587
N K +IE ++
Sbjct: 1697 NESKIEIERLQS 1708
Score = 35.8 bits (81), Expect = 0.12
Identities = 54/220 (24%), Positives = 88/220 (40%), Gaps = 32/220 (14%)
Query: 373 KDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLTESISRGTFFVPGGH 432
+DKS+E QK + + +D+ LQ A Y L LL I R P G
Sbjct: 941 RDKSEEVQK-IAELCANSIKDYELQ----LASYTSG----LETLLNIPIKRTMIQSPSG- 990
Query: 433 NIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAIAAKQ 492
+ L+ + Y + + L L+S +E+ L++ K E+ A+
Sbjct: 991 -VILQEAADVHARYIELLTRSGDYYRFLSEMLKS---LEDLKLKNTKIEVLEEELRLARD 1046
Query: 493 AKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERERENYMRELRKMLSHK 552
A E K + L + QK +Q +Q K K+ + EL++
Sbjct: 1047 ANSENCNKNKFLDQNLQK------------YQAECSQFKAKLAS-----LEELKRQAELD 1089
Query: 553 MKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENEEPSV 592
K ++ L + + +I E LNE+I RL +IE + SV
Sbjct: 1090 GKSAKQNLDKCYGQIKE-LNEKITRLTYEIEDEKRRRKSV 1128
Score = 34.7 bits (78), Expect = 0.28
Identities = 48/230 (20%), Positives = 103/230 (44%), Gaps = 36/230 (15%)
Query: 375 KSQEFQKKLVDTMEKKKEDFVL--QNEEASAKYCQAELKRLSELLTESISRGTFFVPGGH 432
K Q + +L M+++ ED Q+ E +AK Q + K + L E
Sbjct: 1287 KKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAE------------- 1333
Query: 433 NIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQ-------SQVVIEESILQSDKALTAGE 485
EAK++ E + L + +E++ Q ++ I + +Q ++ T+G
Sbjct: 1334 -FQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEED-TSGY 1391
Query: 486 KA-----IAAKQAKKEAAEKEQELLRQKQKEQQQMME--AQERSFQENIAQLKKKMERER 538
+A ++ E ++ + L Q + +++ E Q+++ ++Q K+++E E
Sbjct: 1392 RAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVE- 1450
Query: 539 ENYMRELRKMLSHKMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENE 588
+R++ +M + + ++ L + K I + N+EI RLK+ I+ N+
Sbjct: 1451 ---LRQVTQMRTEESVRYKQSLDDAAKTI-QDKNKEIERLKQLIDKETND 1496
Score = 33.9 bits (76), Expect = 0.47
Identities = 53/269 (19%), Positives = 113/269 (42%), Gaps = 39/269 (14%)
Query: 350 QELLDVHAVCEREAIAVFMEYSF--KDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQ 407
+ L H + E E + +EY + +S+ K +E + + + N +
Sbjct: 1711 ENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLI 1770
Query: 408 AELKRLSELLTESISRGTFFVPGGHNIYLEAKKKI-----EQDYTLVPRKGVKADEVLQS 462
+L+R E L + I + N E+K + E++ LV K ++ D+
Sbjct: 1771 NDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQ 1830
Query: 463 FLQSQVVIEESILQSD----KALTAGEKAIA-------AKQAKKEAA-----------EK 500
L+ ++ +S L+++ + L ++ I + ++KE A E+
Sbjct: 1831 RLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSER 1890
Query: 501 EQELLRQK----QKEQQQMMEAQERSFQENIAQLKKKMERERENYMRELRKML-----SH 551
E+ LR + Q E +++ E R +++ + + ++E ER Y RE+ K+ SH
Sbjct: 1891 EKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSH 1950
Query: 552 KMKVLE-ELLTEGFKEIFESLNEEINRLK 579
+ E E + K +F+ L +++ ++
Sbjct: 1951 RETQTECEWTVDTSKLVFDGLRKKVTAMQ 1979
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 53.5 bits (127), Expect = 6e-07
Identities = 53/243 (21%), Positives = 101/243 (41%), Gaps = 28/243 (11%)
Query: 377 QEFQKKLVDTMEKKKEDFVLQNE-EASAKYCQAELKRLSELLT-------------ESIS 422
++FQ++L D + E F E E AK +A+L +L E L E ++
Sbjct: 1655 KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELA 1714
Query: 423 RGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALT 482
G N + K+++E + + + +++ + Q L
Sbjct: 1715 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA 1774
Query: 483 AGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERS----FQENIAQLKKKMERER 538
++ ++ E++ + LR K E + ++++ +S + IAQL++++E+E
Sbjct: 1775 TERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEA 1834
Query: 539 ENYMRELRKMLSHKMKVLEELL---------TEGFKEIFESLNEEINRLKEQIEAAENEE 589
+ K L K K L+E+L E +KE E N + +LK Q+E AE E
Sbjct: 1835 RE-KQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES 1893
Query: 590 PSV 592
+
Sbjct: 1894 QRI 1896
Score = 38.9 bits (89), Expect = 0.015
Identities = 36/165 (21%), Positives = 82/165 (49%), Gaps = 9/165 (5%)
Query: 440 KKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAKKEAAE 499
K++EQ ++ + + E LQ+ + EE ++ E+ + +A+ E E
Sbjct: 876 KELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEE 935
Query: 500 -KEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMER-ERENYMRELRKML------SH 551
+ Q+L +++K QQM++ +E+ +E A+ K ++E+ E +++L + ++
Sbjct: 936 DRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNN 995
Query: 552 KMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENEEPSVFSQI 596
K+ +LL E ++ +L EE + K + +N+ S+ S++
Sbjct: 996 KLSKERKLLEERISDLTTNLAEEEEKAK-NLTKLKNKHESMISEL 1039
Score = 37.0 bits (84), Expect = 0.056
Identities = 67/299 (22%), Positives = 120/299 (40%), Gaps = 54/299 (18%)
Query: 328 QRAANHYSQ--QMAQQVRFPTDTLQELLDVHAVCEREAIAVFMEYSFKDKSQEFQKKLVD 385
Q+A N + Q Q+ + LQE L A E A A M K QE ++ ++
Sbjct: 869 QKAENELKELEQKHSQLTEEKNLLQEQLQ--AETELYAEAEEMRVRLAAKKQELEE-ILH 925
Query: 386 TMEKKKEDFVLQNEEASAKYCQAELKRLSE--------LLTESISRGTFFVPGGHNIYLE 437
ME + L+ EE + QAE K++++ L E +R + + E
Sbjct: 926 EMEAR-----LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQL---EKVTAE 977
Query: 438 AK-KKIEQDYTLVPRKGVKA-------DEVLQSFLQSQVVIEESILQSDKALTAGEKAIA 489
AK KK+E + ++ + K +E + + EE K E I+
Sbjct: 978 AKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMIS 1037
Query: 490 AKQA---KKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERERE------- 539
+ K+E + +E E L++K + Q Q IA+LK ++ ++ E
Sbjct: 1038 ELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALA 1097
Query: 540 ----------NYMRELRKMLSHKMKVLEELLTE-----GFKEIFESLNEEINRLKEQIE 583
N ++++R++ H + E+L +E ++ L EE+ LK ++E
Sbjct: 1098 RLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELE 1156
Score = 36.2 bits (82), Expect = 0.095
Identities = 32/140 (22%), Positives = 67/140 (47%), Gaps = 18/140 (12%)
Query: 460 LQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQ 519
L+ L S +E + ++ +T +KA+ + EA +E +RQK + + + Q
Sbjct: 1155 LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE---MRQKHAQAVEELTEQ 1211
Query: 520 ERSFQE---NIAQLKKKMERERENYMRELRKM------LSHKMKVLEELLTEGFKEIFE- 569
F+ N+ + K+ +E+E + ELR + + HK K LE + E + +
Sbjct: 1212 LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG 1271
Query: 570 -----SLNEEINRLKEQIEA 584
LN+++++L+ ++E+
Sbjct: 1272 ERARAELNDKVHKLQNEVES 1291
Score = 35.8 bits (81), Expect = 0.12
Identities = 38/176 (21%), Positives = 83/176 (47%), Gaps = 22/176 (12%)
Query: 380 QKKLVDTMEKKKEDF---VLQNEEASAKYC----QAELK-RLSELLTESISRGTFFVPGG 431
Q++LV +EKK+ F + + + S+KY +AE + R E S++R
Sbjct: 1439 QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL------ 1492
Query: 432 HNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAIAAK 491
LEAK+++E+ K +KA+ ++ + S+ + +++ + +K+ A E +
Sbjct: 1493 -EEALEAKEELERT-----NKMLKAE--MEDLVSSKDDVGKNVHELEKSKRALETQMEEM 1544
Query: 492 QAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERERENYMRELRK 547
+ + E E E + + + M+A + F+ ++ ++ E +R R+L +
Sbjct: 1545 KTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1600
Score = 33.5 bits (75), Expect = 0.62
Identities = 58/288 (20%), Positives = 114/288 (39%), Gaps = 49/288 (17%)
Query: 319 AQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCEREAIAVFMEYSFKDKSQE 378
++C + + N ++ +V T L E E +AI + + +
Sbjct: 1266 SKCSDGERARAELNDKVHKLQNEVESVTGMLNE-------AEGKAIKLAKDVA------S 1312
Query: 379 FQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKR--LSELLTESISRGTFFVPGGHNIYL 436
+L DT E +E+ Q S K Q E +R L + L E +
Sbjct: 1313 LSSQLQDTQELLQEE-TRQKLNVSTKLRQLEEERNSLQDQLDEE---------------M 1356
Query: 437 EAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAKKE 496
EAK+ +E+ + + + + + LQ F + +EE + K + + K A +
Sbjct: 1357 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD 1416
Query: 497 AAEKEQELLRQK----------QKEQQQMMEAQERSFQENIAQ---LKKKMERERENYMR 543
EK + L+Q+ Q++ +E ++R F + +A+ + K ER+
Sbjct: 1417 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1476
Query: 544 ELRKMLSHKM---KVLEELLTEGFKEIFESLNEEINRLKEQIEAAENE 588
E R+ + + + LEE L KE E N+ + E + +++++
Sbjct: 1477 EAREKETKALSLARALEEALEA--KEELERTNKMLKAEMEDLVSSKDD 1522
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 53.5 bits (127), Expect = 6e-07
Identities = 53/243 (21%), Positives = 101/243 (41%), Gaps = 28/243 (11%)
Query: 377 QEFQKKLVDTMEKKKEDFVLQNE-EASAKYCQAELKRLSELLT-------------ESIS 422
++FQ++L D + E F E E AK +A+L +L E L E ++
Sbjct: 1662 KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELA 1721
Query: 423 RGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALT 482
G N + K+++E + + + +++ + Q L
Sbjct: 1722 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA 1781
Query: 483 AGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERS----FQENIAQLKKKMERER 538
++ ++ E++ + LR K E + ++++ +S + IAQL++++E+E
Sbjct: 1782 TERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEA 1841
Query: 539 ENYMRELRKMLSHKMKVLEELL---------TEGFKEIFESLNEEINRLKEQIEAAENEE 589
+ K L K K L+E+L E +KE E N + +LK Q+E AE E
Sbjct: 1842 RE-KQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES 1900
Query: 590 PSV 592
+
Sbjct: 1901 QRI 1903
Score = 38.9 bits (89), Expect = 0.015
Identities = 36/165 (21%), Positives = 82/165 (49%), Gaps = 9/165 (5%)
Query: 440 KKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAKKEAAE 499
K++EQ ++ + + E LQ+ + EE ++ E+ + +A+ E E
Sbjct: 883 KELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEE 942
Query: 500 -KEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMER-ERENYMRELRKML------SH 551
+ Q+L +++K QQM++ +E+ +E A+ K ++E+ E +++L + ++
Sbjct: 943 DRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNN 1002
Query: 552 KMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENEEPSVFSQI 596
K+ +LL E ++ +L EE + K + +N+ S+ S++
Sbjct: 1003 KLSKERKLLEERISDLTTNLAEEEEKAK-NLTKLKNKHESMISEL 1046
Score = 37.0 bits (84), Expect = 0.056
Identities = 67/299 (22%), Positives = 120/299 (40%), Gaps = 54/299 (18%)
Query: 328 QRAANHYSQ--QMAQQVRFPTDTLQELLDVHAVCEREAIAVFMEYSFKDKSQEFQKKLVD 385
Q+A N + Q Q+ + LQE L A E A A M K QE ++ ++
Sbjct: 876 QKAENELKELEQKHSQLTEEKNLLQEQLQ--AETELYAEAEEMRVRLAAKKQELEE-ILH 932
Query: 386 TMEKKKEDFVLQNEEASAKYCQAELKRLSE--------LLTESISRGTFFVPGGHNIYLE 437
ME + L+ EE + QAE K++++ L E +R + + E
Sbjct: 933 EMEAR-----LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQL---EKVTAE 984
Query: 438 AK-KKIEQDYTLVPRKGVKA-------DEVLQSFLQSQVVIEESILQSDKALTAGEKAIA 489
AK KK+E + ++ + K +E + + EE K E I+
Sbjct: 985 AKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMIS 1044
Query: 490 AKQA---KKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERERE------- 539
+ K+E + +E E L++K + Q Q IA+LK ++ ++ E
Sbjct: 1045 ELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALA 1104
Query: 540 ----------NYMRELRKMLSHKMKVLEELLTE-----GFKEIFESLNEEINRLKEQIE 583
N ++++R++ H + E+L +E ++ L EE+ LK ++E
Sbjct: 1105 RLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELE 1163
Score = 36.2 bits (82), Expect = 0.095
Identities = 32/140 (22%), Positives = 67/140 (47%), Gaps = 18/140 (12%)
Query: 460 LQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQ 519
L+ L S +E + ++ +T +KA+ + EA +E +RQK + + + Q
Sbjct: 1162 LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE---MRQKHAQAVEELTEQ 1218
Query: 520 ERSFQE---NIAQLKKKMERERENYMRELRKM------LSHKMKVLEELLTEGFKEIFE- 569
F+ N+ + K+ +E+E + ELR + + HK K LE + E + +
Sbjct: 1219 LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG 1278
Query: 570 -----SLNEEINRLKEQIEA 584
LN+++++L+ ++E+
Sbjct: 1279 ERARAELNDKVHKLQNEVES 1298
Score = 35.8 bits (81), Expect = 0.12
Identities = 38/176 (21%), Positives = 83/176 (47%), Gaps = 22/176 (12%)
Query: 380 QKKLVDTMEKKKEDF---VLQNEEASAKYC----QAELK-RLSELLTESISRGTFFVPGG 431
Q++LV +EKK+ F + + + S+KY +AE + R E S++R
Sbjct: 1446 QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL------ 1499
Query: 432 HNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAIAAK 491
LEAK+++E+ K +KA+ ++ + S+ + +++ + +K+ A E +
Sbjct: 1500 -EEALEAKEELERT-----NKMLKAE--MEDLVSSKDDVGKNVHELEKSKRALETQMEEM 1551
Query: 492 QAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERERENYMRELRK 547
+ + E E E + + + M+A + F+ ++ ++ E +R R+L +
Sbjct: 1552 KTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1607
Score = 33.5 bits (75), Expect = 0.62
Identities = 58/288 (20%), Positives = 114/288 (39%), Gaps = 49/288 (17%)
Query: 319 AQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCEREAIAVFMEYSFKDKSQE 378
++C + + N ++ +V T L E E +AI + + +
Sbjct: 1273 SKCSDGERARAELNDKVHKLQNEVESVTGMLNE-------AEGKAIKLAKDVA------S 1319
Query: 379 FQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKR--LSELLTESISRGTFFVPGGHNIYL 436
+L DT E +E+ Q S K Q E +R L + L E +
Sbjct: 1320 LSSQLQDTQELLQEE-TRQKLNVSTKLRQLEEERNSLQDQLDEE---------------M 1363
Query: 437 EAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAKKE 496
EAK+ +E+ + + + + + LQ F + +EE + K + + K A +
Sbjct: 1364 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD 1423
Query: 497 AAEKEQELLRQK----------QKEQQQMMEAQERSFQENIAQ---LKKKMERERENYMR 543
EK + L+Q+ Q++ +E ++R F + +A+ + K ER+
Sbjct: 1424 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1483
Query: 544 ELRKMLSHKM---KVLEELLTEGFKEIFESLNEEINRLKEQIEAAENE 588
E R+ + + + LEE L KE E N+ + E + +++++
Sbjct: 1484 EAREKETKALSLARALEEALEA--KEELERTNKMLKAEMEDLVSSKDD 1529
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 53.5 bits (127), Expect = 6e-07
Identities = 53/243 (21%), Positives = 101/243 (41%), Gaps = 28/243 (11%)
Query: 377 QEFQKKLVDTMEKKKEDFVLQNE-EASAKYCQAELKRLSELLT-------------ESIS 422
++FQ++L D + E F E E AK +A+L +L E L E ++
Sbjct: 1662 KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELA 1721
Query: 423 RGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALT 482
G N + K+++E + + + +++ + Q L
Sbjct: 1722 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA 1781
Query: 483 AGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERS----FQENIAQLKKKMERER 538
++ ++ E++ + LR K E + ++++ +S + IAQL++++E+E
Sbjct: 1782 TERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEA 1841
Query: 539 ENYMRELRKMLSHKMKVLEELL---------TEGFKEIFESLNEEINRLKEQIEAAENEE 589
+ K L K K L+E+L E +KE E N + +LK Q+E AE E
Sbjct: 1842 RE-KQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES 1900
Query: 590 PSV 592
+
Sbjct: 1901 QRI 1903
Score = 38.9 bits (89), Expect = 0.015
Identities = 36/165 (21%), Positives = 82/165 (49%), Gaps = 9/165 (5%)
Query: 440 KKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAKKEAAE 499
K++EQ ++ + + E LQ+ + EE ++ E+ + +A+ E E
Sbjct: 883 KELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEE 942
Query: 500 -KEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMER-ERENYMRELRKML------SH 551
+ Q+L +++K QQM++ +E+ +E A+ K ++E+ E +++L + ++
Sbjct: 943 DRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNN 1002
Query: 552 KMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENEEPSVFSQI 596
K+ +LL E ++ +L EE + K + +N+ S+ S++
Sbjct: 1003 KLSKERKLLEERISDLTTNLAEEEEKAK-NLTKLKNKHESMISEL 1046
Score = 37.0 bits (84), Expect = 0.056
Identities = 67/299 (22%), Positives = 120/299 (40%), Gaps = 54/299 (18%)
Query: 328 QRAANHYSQ--QMAQQVRFPTDTLQELLDVHAVCEREAIAVFMEYSFKDKSQEFQKKLVD 385
Q+A N + Q Q+ + LQE L A E A A M K QE ++ ++
Sbjct: 876 QKAENELKELEQKHSQLTEEKNLLQEQLQ--AETELYAEAEEMRVRLAAKKQELEE-ILH 932
Query: 386 TMEKKKEDFVLQNEEASAKYCQAELKRLSE--------LLTESISRGTFFVPGGHNIYLE 437
ME + L+ EE + QAE K++++ L E +R + + E
Sbjct: 933 EMEAR-----LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQL---EKVTAE 984
Query: 438 AK-KKIEQDYTLVPRKGVKA-------DEVLQSFLQSQVVIEESILQSDKALTAGEKAIA 489
AK KK+E + ++ + K +E + + EE K E I+
Sbjct: 985 AKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMIS 1044
Query: 490 AKQA---KKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERERE------- 539
+ K+E + +E E L++K + Q Q IA+LK ++ ++ E
Sbjct: 1045 ELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALA 1104
Query: 540 ----------NYMRELRKMLSHKMKVLEELLTE-----GFKEIFESLNEEINRLKEQIE 583
N ++++R++ H + E+L +E ++ L EE+ LK ++E
Sbjct: 1105 RLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELE 1163
Score = 36.2 bits (82), Expect = 0.095
Identities = 32/140 (22%), Positives = 67/140 (47%), Gaps = 18/140 (12%)
Query: 460 LQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQ 519
L+ L S +E + ++ +T +KA+ + EA +E +RQK + + + Q
Sbjct: 1162 LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE---MRQKHAQAVEELTEQ 1218
Query: 520 ERSFQE---NIAQLKKKMERERENYMRELRKM------LSHKMKVLEELLTEGFKEIFE- 569
F+ N+ + K+ +E+E + ELR + + HK K LE + E + +
Sbjct: 1219 LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG 1278
Query: 570 -----SLNEEINRLKEQIEA 584
LN+++++L+ ++E+
Sbjct: 1279 ERARAELNDKVHKLQNEVES 1298
Score = 35.8 bits (81), Expect = 0.12
Identities = 38/176 (21%), Positives = 83/176 (47%), Gaps = 22/176 (12%)
Query: 380 QKKLVDTMEKKKEDF---VLQNEEASAKYC----QAELK-RLSELLTESISRGTFFVPGG 431
Q++LV +EKK+ F + + + S+KY +AE + R E S++R
Sbjct: 1446 QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL------ 1499
Query: 432 HNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAIAAK 491
LEAK+++E+ K +KA+ ++ + S+ + +++ + +K+ A E +
Sbjct: 1500 -EEALEAKEELERT-----NKMLKAE--MEDLVSSKDDVGKNVHELEKSKRALETQMEEM 1551
Query: 492 QAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERERENYMRELRK 547
+ + E E E + + + M+A + F+ ++ ++ E +R R+L +
Sbjct: 1552 KTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1607
Score = 33.5 bits (75), Expect = 0.62
Identities = 58/288 (20%), Positives = 114/288 (39%), Gaps = 49/288 (17%)
Query: 319 AQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCEREAIAVFMEYSFKDKSQE 378
++C + + N ++ +V T L E E +AI + + +
Sbjct: 1273 SKCSDGERARAELNDKVHKLQNEVESVTGMLNE-------AEGKAIKLAKDVA------S 1319
Query: 379 FQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKR--LSELLTESISRGTFFVPGGHNIYL 436
+L DT E +E+ Q S K Q E +R L + L E +
Sbjct: 1320 LSSQLQDTQELLQEE-TRQKLNVSTKLRQLEEERNSLQDQLDEE---------------M 1363
Query: 437 EAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAKKE 496
EAK+ +E+ + + + + + LQ F + +EE + K + + K A +
Sbjct: 1364 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD 1423
Query: 497 AAEKEQELLRQK----------QKEQQQMMEAQERSFQENIAQ---LKKKMERERENYMR 543
EK + L+Q+ Q++ +E ++R F + +A+ + K ER+
Sbjct: 1424 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1483
Query: 544 ELRKMLSHKM---KVLEELLTEGFKEIFESLNEEINRLKEQIEAAENE 588
E R+ + + + LEE L KE E N+ + E + +++++
Sbjct: 1484 EAREKETKALSLARALEEALEA--KEELERTNKMLKAEMEDLVSSKDD 1529
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 53.5 bits (127), Expect = 6e-07
Identities = 53/243 (21%), Positives = 101/243 (41%), Gaps = 28/243 (11%)
Query: 377 QEFQKKLVDTMEKKKEDFVLQNE-EASAKYCQAELKRLSELLT-------------ESIS 422
++FQ++L D + E F E E AK +A+L +L E L E ++
Sbjct: 1655 KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELA 1714
Query: 423 RGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALT 482
G N + K+++E + + + +++ + Q L
Sbjct: 1715 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA 1774
Query: 483 AGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERS----FQENIAQLKKKMERER 538
++ ++ E++ + LR K E + ++++ +S + IAQL++++E+E
Sbjct: 1775 TERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEA 1834
Query: 539 ENYMRELRKMLSHKMKVLEELL---------TEGFKEIFESLNEEINRLKEQIEAAENEE 589
+ K L K K L+E+L E +KE E N + +LK Q+E AE E
Sbjct: 1835 RE-KQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES 1893
Query: 590 PSV 592
+
Sbjct: 1894 QRI 1896
Score = 38.9 bits (89), Expect = 0.015
Identities = 36/165 (21%), Positives = 82/165 (49%), Gaps = 9/165 (5%)
Query: 440 KKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAKKEAAE 499
K++EQ ++ + + E LQ+ + EE ++ E+ + +A+ E E
Sbjct: 876 KELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEE 935
Query: 500 -KEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMER-ERENYMRELRKML------SH 551
+ Q+L +++K QQM++ +E+ +E A+ K ++E+ E +++L + ++
Sbjct: 936 DRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNN 995
Query: 552 KMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENEEPSVFSQI 596
K+ +LL E ++ +L EE + K + +N+ S+ S++
Sbjct: 996 KLSKERKLLEERISDLTTNLAEEEEKAK-NLTKLKNKHESMISEL 1039
Score = 37.0 bits (84), Expect = 0.056
Identities = 67/299 (22%), Positives = 120/299 (40%), Gaps = 54/299 (18%)
Query: 328 QRAANHYSQ--QMAQQVRFPTDTLQELLDVHAVCEREAIAVFMEYSFKDKSQEFQKKLVD 385
Q+A N + Q Q+ + LQE L A E A A M K QE ++ ++
Sbjct: 869 QKAENELKELEQKHSQLTEEKNLLQEQLQ--AETELYAEAEEMRVRLAAKKQELEE-ILH 925
Query: 386 TMEKKKEDFVLQNEEASAKYCQAELKRLSE--------LLTESISRGTFFVPGGHNIYLE 437
ME + L+ EE + QAE K++++ L E +R + + E
Sbjct: 926 EMEAR-----LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQL---EKVTAE 977
Query: 438 AK-KKIEQDYTLVPRKGVKA-------DEVLQSFLQSQVVIEESILQSDKALTAGEKAIA 489
AK KK+E + ++ + K +E + + EE K E I+
Sbjct: 978 AKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMIS 1037
Query: 490 AKQA---KKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERERE------- 539
+ K+E + +E E L++K + Q Q IA+LK ++ ++ E
Sbjct: 1038 ELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALA 1097
Query: 540 ----------NYMRELRKMLSHKMKVLEELLTE-----GFKEIFESLNEEINRLKEQIE 583
N ++++R++ H + E+L +E ++ L EE+ LK ++E
Sbjct: 1098 RLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELE 1156
Score = 36.2 bits (82), Expect = 0.095
Identities = 32/140 (22%), Positives = 67/140 (47%), Gaps = 18/140 (12%)
Query: 460 LQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQ 519
L+ L S +E + ++ +T +KA+ + EA +E +RQK + + + Q
Sbjct: 1155 LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE---MRQKHAQAVEELTEQ 1211
Query: 520 ERSFQE---NIAQLKKKMERERENYMRELRKM------LSHKMKVLEELLTEGFKEIFE- 569
F+ N+ + K+ +E+E + ELR + + HK K LE + E + +
Sbjct: 1212 LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG 1271
Query: 570 -----SLNEEINRLKEQIEA 584
LN+++++L+ ++E+
Sbjct: 1272 ERARAELNDKVHKLQNEVES 1291
Score = 35.8 bits (81), Expect = 0.12
Identities = 38/176 (21%), Positives = 83/176 (47%), Gaps = 22/176 (12%)
Query: 380 QKKLVDTMEKKKEDF---VLQNEEASAKYC----QAELK-RLSELLTESISRGTFFVPGG 431
Q++LV +EKK+ F + + + S+KY +AE + R E S++R
Sbjct: 1439 QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL------ 1492
Query: 432 HNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAIAAK 491
LEAK+++E+ K +KA+ ++ + S+ + +++ + +K+ A E +
Sbjct: 1493 -EEALEAKEELERT-----NKMLKAE--MEDLVSSKDDVGKNVHELEKSKRALETQMEEM 1544
Query: 492 QAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERERENYMRELRK 547
+ + E E E + + + M+A + F+ ++ ++ E +R R+L +
Sbjct: 1545 KTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1600
Score = 33.5 bits (75), Expect = 0.62
Identities = 58/288 (20%), Positives = 114/288 (39%), Gaps = 49/288 (17%)
Query: 319 AQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCEREAIAVFMEYSFKDKSQE 378
++C + + N ++ +V T L E E +AI + + +
Sbjct: 1266 SKCSDGERARAELNDKVHKLQNEVESVTGMLNE-------AEGKAIKLAKDVA------S 1312
Query: 379 FQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKR--LSELLTESISRGTFFVPGGHNIYL 436
+L DT E +E+ Q S K Q E +R L + L E +
Sbjct: 1313 LSSQLQDTQELLQEE-TRQKLNVSTKLRQLEEERNSLQDQLDEE---------------M 1356
Query: 437 EAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAKKE 496
EAK+ +E+ + + + + + LQ F + +EE + K + + K A +
Sbjct: 1357 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD 1416
Query: 497 AAEKEQELLRQK----------QKEQQQMMEAQERSFQENIAQ---LKKKMERERENYMR 543
EK + L+Q+ Q++ +E ++R F + +A+ + K ER+
Sbjct: 1417 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1476
Query: 544 ELRKMLSHKM---KVLEELLTEGFKEIFESLNEEINRLKEQIEAAENE 588
E R+ + + + LEE L KE E N+ + E + +++++
Sbjct: 1477 EAREKETKALSLARALEEALEA--KEELERTNKMLKAEMEDLVSSKDD 1522
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 52.8 bits (125), Expect = 1e-06
Identities = 48/223 (21%), Positives = 106/223 (47%), Gaps = 21/223 (9%)
Query: 368 MEYSFKDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLTESISRGTFF 427
+E + K + + ++ L +T K D +Q E +A+ E K + L E IS T
Sbjct: 1897 VEETLKLERDQLKESLQET---KARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQ 1953
Query: 428 VPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKA 487
+ ++K ++++ + +K ++ V + S I E + +K
Sbjct: 1954 ISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINE--------MEQLKKQ 2005
Query: 488 IAAKQAKKEAAEKEQELLRQKQKEQQQMME--AQERSFQENIAQLKKKMERERENYMREL 545
A+ ++ + L +K E + + A+ER + + ++K+ ++ ER+ ++ L
Sbjct: 2006 FEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKER---DELRRIKESLKMERDQFIATL 2062
Query: 546 RKMLS-----HKMKVLEELLTEGFKEIFESLNEEINRLKEQIE 583
R+M++ H++K + LL++G + + ESL E+ +R+KE ++
Sbjct: 2063 REMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLK 2105
Score = 38.1 bits (87), Expect = 0.025
Identities = 60/307 (19%), Positives = 122/307 (39%), Gaps = 33/307 (10%)
Query: 290 NRLGMLVETYLDAINSGATPCLENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTL 349
N L ++E+ + T EN + EN ++ + +Q + +
Sbjct: 1053 NELQQMLESVIAEKEQLKTDLKENIEMTI---ENQEELRLLGDELKKQQEIVAQEKNHAI 1109
Query: 350 QELLDVHAVCEREAIAVFMEYSFKDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAE 409
++ ++ C+R A +E K+KSQ+ Q+K + ++E +Q + + + E
Sbjct: 1110 KKEGELSRTCDRLAE---VEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNE 1166
Query: 410 LKRLSELLTESISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVV 469
LK EL E + LE +K+ ++Y V K + + + LQ
Sbjct: 1167 LKN-KELTLEHMETER----------LELAQKLNENYEEV--KSITKERKVLKELQKSFE 1213
Query: 470 IEESILQSDKALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQ 529
E L+ I +A ++E ++ KE Q+ ++ RS E AQ
Sbjct: 1214 TERDHLRG---------YIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQ 1264
Query: 530 LKKKMERERENYMRELRKMLSHKMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENEE 589
+ + E+ + + + H+ E+ L KE+ E+ E +N L+ E + ++
Sbjct: 1265 IINTQDLEKSHTKLQEEIPVLHE----EQELLPNVKEVSET-QETMNELELLTEQSTTKD 1319
Query: 590 PSVFSQI 596
+ ++I
Sbjct: 1320 STTLARI 1326
Score = 33.1 bits (74), Expect = 0.80
Identities = 65/353 (18%), Positives = 138/353 (39%), Gaps = 35/353 (9%)
Query: 251 EVREDQLDSNFQMQSENFCSYIFTHAKTKTLREGILVTGNRLGMLVETYLDAINSGATPC 310
E+ +L+ FQ E S KT++E + V ++L + L I +
Sbjct: 1327 EMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSK- 1385
Query: 311 LENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTL---QELLDVHAVCEREAIAVF 367
E ++ + + + + + + + +R + L + L + H E +++A
Sbjct: 1386 QEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHD--EMKSVA-- 1441
Query: 368 MEYSFKDKSQEFQKKLVDTMEKKKEDF-------VLQNEEASAKYC-----QAELKRLSE 415
KD Q Q+ L ++ KE+ + EE +C + + L
Sbjct: 1442 ---KEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRV 1498
Query: 416 LLTESISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESIL 475
L+E + + I + + KI++ Y + +K +Q + +E
Sbjct: 1499 NLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRK 1558
Query: 476 QSDKALTAGE-KAIAAKQAKKEAAEKEQELLRQKQ--KEQQQMMEAQERSFQEN----IA 528
D AL + E K + +E+ E+ Q ++++K+ K Q+ ++ + +EN +A
Sbjct: 1559 AKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVA 1618
Query: 529 QLKKKMERERENYMRELRKMLSHKMKVLEELLTEGFKEIFESLNEEINRLKEQ 581
++K+ E+E + KM +E L KE FE+ + ++ +
Sbjct: 1619 KMKESQEKEYQFLKMTAVNETQEKMCEIEHL-----KEQFETQKLNLENIETE 1666
Score = 32.3 bits (72), Expect = 1.4
Identities = 51/222 (22%), Positives = 94/222 (42%), Gaps = 31/222 (13%)
Query: 375 KSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLTESISRGTFFVPGGHNI 434
K+QE Q+K + E+ E L+ + + ++R L+TE +
Sbjct: 871 KTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKL------------- 917
Query: 435 YLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAK 494
++ +E+ TL K D++ Q LQ + IE L+SD T +Q +
Sbjct: 918 ----QQTLEEVKTLTQEK----DDLKQ--LQESLQIERDQLKSDIHDTVNMNIDTQEQLR 967
Query: 495 K--EAAEKEQE---LLRQKQKEQQQMMEAQERSFQENIAQLKKKMERERENYMRELRKML 549
E+ ++ QE L+ K E+ E + E + ++KM + E +
Sbjct: 968 NALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQ 1027
Query: 550 SHKMKVLEELLTEGFKEIFESLNEEINRLKEQIEA--AENEE 589
+ V + + E ++IF SL +E N L++ +E+ AE E+
Sbjct: 1028 TLTADVKDNEIIEQQRKIF-SLIQEKNELQQMLESVIAEKEQ 1068
Score = 32.3 bits (72), Expect = 1.4
Identities = 46/232 (19%), Positives = 102/232 (43%), Gaps = 27/232 (11%)
Query: 374 DKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLTESISRGTFFVPGGHN 433
DK Q+ + K T+ +D + ++ E L ++L I+
Sbjct: 1016 DKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEK-------EQ 1068
Query: 434 IYLEAKKKIE------QDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKA 487
+ + K+ IE ++ L+ + K E++ + E + ++ L E+
Sbjct: 1069 LKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEK 1128
Query: 488 IAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERERENYMRELRK 547
+ K+ ++ EK+Q+LL Q++M E Q++ I ++ + ++ E +N L
Sbjct: 1129 L--KEKSQQLQEKQQQLL----NVQEEMSEMQKK-----INEI-ENLKNELKNKELTLEH 1176
Query: 548 MLSHKMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENEEPSVFSQILDV 599
M + +++ L + L E ++E+ +S+ +E LKE ++ E E + I ++
Sbjct: 1177 METERLE-LAQKLNENYEEV-KSITKERKVLKELQKSFETERDHLRGYIREI 1226
Score = 32.3 bits (72), Expect = 1.4
Identities = 29/144 (20%), Positives = 68/144 (47%), Gaps = 16/144 (11%)
Query: 460 LQSFLQSQVVIEESILQSDKALTAGEKAIAA-KQAKKEAAEKEQEL---------LRQKQ 509
LQ +Q E ++ K + +K ++ +Q KK+ ++ L L QK
Sbjct: 1818 LQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKL 1877
Query: 510 KEQQQMMEAQERSFQENIAQLKKKMERERENYMRELRKMLSHKMKVLEEL-----LTEGF 564
E + M++ + ++N+ ++++ ++ ER+ L++ + +++ +EL L++
Sbjct: 1878 HENLEEMKSVMKE-RDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEH 1936
Query: 565 KEIFESLNEEINRLKEQIEAAENE 588
KE + L E+I+ QI + +
Sbjct: 1937 KETVDKLREKISEKTIQISDIQKD 1960
Score = 30.0 bits (66), Expect = 6.8
Identities = 28/98 (28%), Positives = 49/98 (50%), Gaps = 21/98 (21%)
Query: 499 EKEQELLRQKQKEQQQMMEAQERSFQEN--------IAQLKKKMERERENYMRELRKMLS 550
EKE+ L+ K+K EA ER +++ I+ L K + + E Y ++L LS
Sbjct: 520 EKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNL-KNLVKHAEVYNQDLENELS 578
Query: 551 HKMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENE 588
K+++L E KE ++I +L+E I++ + E
Sbjct: 579 SKVELLRE------KE------DQIKKLQEYIDSQKLE 604
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 52.0 bits (123), Expect = 2e-06
Identities = 51/226 (22%), Positives = 104/226 (46%), Gaps = 19/226 (8%)
Query: 369 EYSFKDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLTESISRGTFFV 428
E + K+QE +KK D EK +E+ ++ E + + ++ E + E +
Sbjct: 564 EERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEK----- 618
Query: 429 PGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAI 488
+ + +K EQ+ + ++ ++ + + Q + + E+ L K + +
Sbjct: 619 -----MQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKM 673
Query: 489 AAKQAKKEAAEK--EQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERERENYMRELR 546
++ +E EK EQE + +K +EQ++ QE+ +E + ++K RE E MRE
Sbjct: 674 QEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQE 733
Query: 547 KMLSHKMKVLEELLTEGFKEIF---ESLNEEINRLKEQIEAAENEE 589
+ KM+ EE + E +E++ E + E+ ++ EQ E +E
Sbjct: 734 E----KMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKE 775
Score = 49.7 bits (117), Expect = 8e-06
Identities = 52/221 (23%), Positives = 107/221 (48%), Gaps = 13/221 (5%)
Query: 376 SQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLTESISRGTFFVPGGH-NI 434
S E + + E KK++ LQ + A+ ++E++ + L + R F +P N
Sbjct: 210 SLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNT 269
Query: 435 YLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAK 494
E + E++ +K K +E + + E + + ++ + EK + ++ +
Sbjct: 270 LQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRL--REQE 327
Query: 495 KEAAEKEQELLRQKQKE----QQQMMEAQERSF--QENIAQLKKKMERERENYMRELRKM 548
KE E+E+EL ++QKE ++QM E +E+ + +E + + ++KM R+ E + ++M
Sbjct: 328 KELREQEKEL--REQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQM 385
Query: 549 LSHKMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENEE 589
+ K+ ++ E E E L E+ R++EQ + E E
Sbjct: 386 REQEQKMRDQ--EERMWEQDERLREKEERMREQEKMWEQVE 424
Score = 48.1 bits (113), Expect = 2e-05
Identities = 49/233 (21%), Positives = 101/233 (43%), Gaps = 25/233 (10%)
Query: 375 KSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLTESISRGTFFVPGGHNI 434
K QE +KK D EK +E+ ++ E + + ++ E + + N+
Sbjct: 431 KMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQ----------EENM 480
Query: 435 YLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAK 494
+ + +K+ +Q ++ + E +Q Q + + E+ D+ G++ +Q K
Sbjct: 481 WEQEEKEWQQQRLPEQKEKLWEQEKMQE--QEEKIWEQEEKIRDQEEMWGQEKKMWRQEK 538
Query: 495 KEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKM------------ERERENYM 542
E + +K ++Q+Q M QE ++ + +KK RERE M
Sbjct: 539 MREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKM 598
Query: 543 RELRKMLSHKMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENEEPSVFSQ 595
RE +M+ + + ++E E +E E + E+ +++EQ E +E ++ Q
Sbjct: 599 REEEEMMREQEEKMQE-QEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQ 650
Score = 46.2 bits (108), Expect = 9e-05
Identities = 47/233 (20%), Positives = 103/233 (44%), Gaps = 15/233 (6%)
Query: 373 KDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAEL----------KRLSELLTESIS 422
K++ Q+K+ + +EK +E+ +Q +E + + ++ K++ E
Sbjct: 409 KEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMRE 468
Query: 423 RGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALT 482
+ N++ + +K+ +Q ++ + E +Q Q + + E+ D+
Sbjct: 469 QEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQE--QEEKIWEQEEKIRDQEEM 526
Query: 483 AGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERERENYM 542
G++ +Q K E + +K ++Q+Q M QE ++ + +KK ++E M
Sbjct: 527 WGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKK-TWDQEEKM 585
Query: 543 RELRKMLSHKMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENEEPSVFSQ 595
RE +M + K+ EE E +E E + E+ +++EQ E +E + Q
Sbjct: 586 REEERMREREKKMREE--EEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQ 636
Score = 45.1 bits (105), Expect = 2e-04
Identities = 49/260 (18%), Positives = 124/260 (47%), Gaps = 11/260 (4%)
Query: 336 QQMAQQVRFPTDTLQELLDVHAVCEREAIAVFMEYSFKDKSQEFQKKLVDTMEKKKEDFV 395
++M +Q + D +++ + + ERE E + +++ ++ QK+ + E++++++
Sbjct: 430 KKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQ 489
Query: 396 LQN--EEASAKYCQAELKRLSELLTESIS--RGTFFVPGGHNIYLEAKKKIEQDYTLVPR 451
Q E+ + Q +++ E + E R + G +K EQ+ + +
Sbjct: 490 QQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQ 549
Query: 452 KGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAK-KEAAEKEQELLRQKQK 510
+ D+ + + Q + + +++ Q K EK ++ + +E +E+E + ++Q+
Sbjct: 550 EEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQE 609
Query: 511 EQQQMMEAQERSFQENIAQLKKKMERERENYMRELRKMLSHKMKVLE-ELLTEGFKEIFE 569
E+ Q E + + +E + + ++KM+ + E + KM + K+ E + L E ++++E
Sbjct: 610 EKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWE 669
Query: 570 SLNEEINRLKEQIEAAENEE 589
+++EQ + E EE
Sbjct: 670 H-----EKMQEQEKMQEQEE 684
Score = 42.4 bits (98), Expect = 0.001
Identities = 32/120 (26%), Positives = 62/120 (51%), Gaps = 9/120 (7%)
Query: 471 EESILQSDKALTAGEKAIAAKQAKKEAAEK----EQELLRQKQ---KEQQQMMEAQERSF 523
EE + + ++ L EK + ++ K E+ + E LR+K+ +EQ++M E E+
Sbjct: 368 EEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMR 427
Query: 524 QENIAQLKKKMERERENYMRELRKMLSHKMKVLEELLTEGFKEIFESLNEEINRLKEQIE 583
+E Q ++K R++E M+E ++ + K+ EE E +E E + ++ + EQ E
Sbjct: 428 EEKKMQEQEKKTRDQEEKMQEEERIREREKKMREE--EETMREQEEKMQKQEENMWEQEE 485
Score = 40.8 bits (94), Expect = 0.004
Identities = 55/245 (22%), Positives = 102/245 (41%), Gaps = 33/245 (13%)
Query: 360 EREAIAVFMEYSFKDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLTE 419
+R AV + D+ E K D + + + NEE K AEL+ L
Sbjct: 182 QRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKK--NAELQEKLPLAES 239
Query: 420 SISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDK 479
S V E K+K+E+ L+P+ ++E + + ++
Sbjct: 240 EKSEIQLNVK-------ELKRKLERAKFLLPQVQTNT-------------LQEEMWRQEE 279
Query: 480 ALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERERE 539
L EK I ++ K E+ K +EQ++ M QE+ +E +L+++ + RE
Sbjct: 280 ELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELRE 339
Query: 540 NYMRELRKM------LSHKMKVLEELLTEGFKEIF---ESLNEEINRLKEQIEAAENEEP 590
+ELR+ KM EE + E ++++ E L E+ +++EQ + ++E
Sbjct: 340 --QKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEE 397
Query: 591 SVFSQ 595
++ Q
Sbjct: 398 RMWEQ 402
Score = 40.4 bits (93), Expect = 0.005
Identities = 53/262 (20%), Positives = 111/262 (42%), Gaps = 28/262 (10%)
Query: 336 QQMAQQVRFPTDTLQELLDVHAVCEREAIAVFMEYSFKDKSQEFQKKLVDTMEKKKEDFV 395
++M +Q R P + ++L + + E+E + E K QE +K EKK D
Sbjct: 652 EKMWEQQRLP-EQKEKLWEHEKMQEQEKM---QEQEEKIWEQEKMEKKTQEQEKKTWDQE 707
Query: 396 LQNEEASAKYCQAELKRLSELLTESISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVK 455
EE S + + +++ E++ E + +K EQ+ + ++
Sbjct: 708 KMREEESMREREKKMREEEEMMRE-----------------QEEKMQEQEEKMQEQEEEM 750
Query: 456 ADEVLQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQM 515
++ + + Q + + E+ L K EK ++ +++ EQE + Q+E+ +
Sbjct: 751 WEQEEKMWEQEEKMWEQQRLPEQK-----EKLWEHEKMQEQEKIWEQEEKMRDQEEKMRG 805
Query: 516 MEAQERSFQENIAQLKKKMERERENYMRELRKMLSHKMKV--LEELLTEGFKEIFESLNE 573
E + R +E + ++KM + E + KM + K+ EE + E + E + E
Sbjct: 806 QEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMRE 865
Query: 574 EINRLKEQIEAAENEEPSVFSQ 595
+ +++ Q E +E + Q
Sbjct: 866 QEEKMRGQEEKMREQEEKMRGQ 887
Score = 39.7 bits (91), Expect = 0.009
Identities = 36/164 (21%), Positives = 78/164 (47%), Gaps = 11/164 (6%)
Query: 437 EAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAKKE 496
+ K+ EQ+ L +K ++ E +Q Q EE + + ++ + E+ + ++ +
Sbjct: 326 QEKELREQEKELREQKELREQE---EQMQEQ---EEKMWEQEEKMREQEEKMWRQEERLW 379
Query: 497 AAEKEQELLRQKQKEQQQMM-EAQERSFQENIAQLKKKMERERENYMRELRKMLSHKMKV 555
EK+ QK ++Q++ M E ER ++ +++ E+ MRE +KM + K
Sbjct: 380 EQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKT 439
Query: 556 LEE----LLTEGFKEIFESLNEEINRLKEQIEAAENEEPSVFSQ 595
++ E +E + + EE ++EQ E + +E +++ Q
Sbjct: 440 RDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQ 483
Score = 38.5 bits (88), Expect = 0.019
Identities = 45/229 (19%), Positives = 107/229 (46%), Gaps = 16/229 (6%)
Query: 373 KDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLTESISRGTFFVPGGH 432
++K QE ++K+ + EK +E E+ + Q E + L E + H
Sbjct: 616 EEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEK-----LWEH 670
Query: 433 NIYLEAKKKIEQDYTLVPRKGVKA---DEVLQSFLQSQVVIEESILQSDKALTAGEKAIA 489
E +K EQ+ + ++ ++ ++ +++ Q ++ EES+ + +K + E+ +
Sbjct: 671 EKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMR 730
Query: 490 AKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSF--QENIAQLKKKM-ERERENYMRELR 546
++ K + E++ + ++ EQ++ M QE Q+ + + K+K+ E E+ M+E
Sbjct: 731 EQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEK---MQEQE 787
Query: 547 KMLSHKMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENEEPSVFSQ 595
K+ + K+ ++ E + E + + +++ Q E +E ++ Q
Sbjct: 788 KIWEQEEKMRDQ--EEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQ 834
Score = 35.8 bits (81), Expect = 0.12
Identities = 29/134 (21%), Positives = 66/134 (49%), Gaps = 20/134 (14%)
Query: 471 EESILQSDKALTAGEKAIAAK-----QAKKEAAEKEQELLRQKQKEQQQMMEAQER---- 521
EE + + D+ L E+ + + Q +K EK+ + +K ++Q++ M+ +ER
Sbjct: 396 EERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIRER 455
Query: 522 -----SFQENIAQLKKKMEREREN-YMRELRKMLSHKMKVLEELLTEGFKEIFESLNEEI 575
+E + + ++KM+++ EN + +E ++ ++ +E L E E + E+
Sbjct: 456 EKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQ-----EKMQEQE 510
Query: 576 NRLKEQIEAAENEE 589
++ EQ E ++E
Sbjct: 511 EKIWEQEEKIRDQE 524
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 50.8 bits (120), Expect = 4e-06
Identities = 73/326 (22%), Positives = 139/326 (42%), Gaps = 30/326 (9%)
Query: 300 LDAINSGATPCLENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVC 359
LD N LEN+ + Q E+ N Q+ ++++ + L++L +
Sbjct: 761 LDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSL 820
Query: 360 EREAIAVFMEYSFKDKSQEFQKKLVD----TMEK--------KKEDFVLQNEEASAKYCQ 407
E+E + + +K + ++ + T+E+ +KE+ L E K
Sbjct: 821 EQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESC 880
Query: 408 AELKRLSELLTESISRGTF----FVPGGHNIYLEAKKKIEQDYTL------VPRKGVKAD 457
LK L + E + R T V ++ E K + + L + + G+ +
Sbjct: 881 VRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKE 940
Query: 458 EVL---QSFLQSQVVIEESILQSD--KALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQ 512
+L QS S+ + ES L+S K+L E+ IAA +A+ E + + LRQ+ K
Sbjct: 941 RLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTV 1000
Query: 513 QQMMEA-QERSFQENIAQLKKKMERERENYMRELRKMLSHKMKVLEELLTEGFKEIFESL 571
++ EA ++R +E + Q + E + RE ++ +KV + L+ + +L
Sbjct: 1001 KKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIE--VERNNATL 1058
Query: 572 NEEINRLKEQIEAAENEEPSVFSQIL 597
E LK Q++ E + ++ +QIL
Sbjct: 1059 QAEKQALKTQLKQLETQNNNLQAQIL 1084
Score = 39.7 bits (91), Expect = 0.009
Identities = 67/358 (18%), Positives = 140/358 (39%), Gaps = 38/358 (10%)
Query: 238 RPINDKKLLLHVEEVREDQLDSNFQMQSENFCSYIFTHAKTKTLREGILVTGNRLGMLVE 297
R D+ L + VR D+L+S E F A+ + L+E N++ + +
Sbjct: 306 RMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKE-----DNQVLLETK 360
Query: 298 TYLDAINSGATPCLENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHA 357
T L+ G + L + E +A H + R + L E
Sbjct: 361 TMLEDQLEGTRARSDK----LHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLE 416
Query: 358 VCEREAIAVFMEYSFKDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELL 417
+ +++++ + ++ + +L + +K V NE S++ + E++ S
Sbjct: 417 MAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEV--NELTSSRLLKLEMENQSLTK 474
Query: 418 TESISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQS 477
T R T G+ K +K ++ Q + ++E I+Q
Sbjct: 475 TVEELRTTVDSVEGN-----------------ASKILKMEKENQRLSKKVEILENEIVQE 517
Query: 478 DKALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERE 537
++L + +K EK E LR+ + Q +++E + + ++ L+++ +
Sbjct: 518 KQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQIS 577
Query: 538 RENYMRELRKMLSHKMKVLEELLTEGFKEI----FE--SLNEEINRLKEQIEAAENEE 589
E ++++ K + K+L E + E ++ FE + +E+ KE+ E AE E
Sbjct: 578 AEARVKDIEK----ENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELE 631
Score = 35.4 bits (80), Expect = 0.16
Identities = 44/220 (20%), Positives = 98/220 (44%), Gaps = 31/220 (14%)
Query: 390 KKEDFVLQNEEASAKYCQAELKRLSELLTESISRGTFFVPGGHNIYLEAKKKIEQDYTLV 449
K L+N+E ++ + +LK+ ELL S + + +E +++++
Sbjct: 719 KMAQLQLENKELESE--KEQLKKGLELLKASFKKTERLEVSYQGLDIE-NQRLQKTLENS 775
Query: 450 PRKGVKADEVLQSFLQSQVVIEESILQ---SDKALTAGEKAIAAKQAKKEAAEKEQELLR 506
+K + + LQ +++++ + S K L EK + + + EK+++ L
Sbjct: 776 NKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLE 835
Query: 507 QKQKEQQQMMEAQERSFQEN---IAQLKKKME----------------RERENYMRELRK 547
++ K +Q E ++ + +EN I L+K+ + +E E +EL K
Sbjct: 836 KENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVK 895
Query: 548 MLSHKMKVL----EELLTEGFKEIFESLNEEINRLKEQIE 583
+ +K L E+L++E K + +N ++ +L ++E
Sbjct: 896 RATIDIKTLVTLREDLVSEKLKT--QQMNNDLEKLTHELE 933
Score = 35.0 bits (79), Expect = 0.21
Identities = 66/287 (22%), Positives = 120/287 (41%), Gaps = 41/287 (14%)
Query: 300 LDAINSGATPCLENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVC 359
L+ N T +E + E +A+ +Q+++++V E+L+ V
Sbjct: 465 LEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKV--------EILENEIVQ 516
Query: 360 EREAIAVFMEYSFKDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLTE 419
E++++ S KD +E + +L T+E +E N E K + E + L++ ++
Sbjct: 517 EKQSLQNCQNLS-KDLMKE-KAQLEKTIETLRE-----NSERQIKILEQENEHLNQTVSS 569
Query: 420 SISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDK 479
R I EA+ K + + + +K S ++ + + L+ K
Sbjct: 570 LRQRS--------QISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYK 621
Query: 480 ALTAGEKAIAAKQAKKEA--AEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERE 537
EK A++ + E EKE ELL++K + E E QEN E E
Sbjct: 622 -----EKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQEN-------SELE 669
Query: 538 RENYMRELRKMLSHKMKVLEELLTEGFKEIFESLNEEINRLKEQIEA 584
REN R+L+K L + +L E ++ L+EE L+ +E+
Sbjct: 670 REN--RKLKKTLDSFKNLTFQL--ESLEKENSQLDEENLELRRNVES 712
Score = 35.0 bits (79), Expect = 0.21
Identities = 53/245 (21%), Positives = 104/245 (42%), Gaps = 50/245 (20%)
Query: 375 KSQEFQKKLVDTMEKKKEDFVLQNEEASAKY----------------CQAELKRLSELLT 418
K +E K L D++ K E L +E +++Y + E + L +
Sbjct: 1144 KEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYN 1203
Query: 419 ESISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKA------------DEVLQSFLQS 466
+ + + G LE K+EQ+ L+ K + D + ++ S
Sbjct: 1204 QLLKQK------GQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTY--S 1255
Query: 467 QVVIEESILQSD-KALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQ- 524
Q++ E +LQ+D K L + +K E E E + K++ QQ + + + + Q
Sbjct: 1256 QLLKETEVLQTDHKNLKS-----LLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQC 1310
Query: 525 ENIAQLKKKMERERENYMRELRKMLSHKMKVLE------ELLTEGFKEIFESLNEEINRL 578
E ++QLK +E E + + +++ ++ +LE +L ++ + LN E+ R
Sbjct: 1311 ELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLN-ELRRQ 1369
Query: 579 KEQIE 583
KE++E
Sbjct: 1370 KEKLE 1374
Score = 29.6 bits (65), Expect = 8.9
Identities = 30/167 (17%), Positives = 68/167 (40%), Gaps = 23/167 (13%)
Query: 453 GVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAKKEAAEKEQELLRQK---- 508
G + +E+ S L + +S+ ++ + L ++ +K EKE + L +K
Sbjct: 451 GHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEIL 510
Query: 509 ------QKEQQQMMEAQERSFQENIAQLKKKMERERENYMRELR-------------KML 549
+K+ Q + + + AQL+K +E REN R+++ L
Sbjct: 511 ENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSL 570
Query: 550 SHKMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENEEPSVFSQI 596
+ ++ E + ++ + L+E I ++ E E+ + ++
Sbjct: 571 RQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKEL 617
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 50.1 bits (118), Expect = 6e-06
Identities = 73/327 (22%), Positives = 139/327 (42%), Gaps = 58/327 (17%)
Query: 318 LAQCENSAAVQRAANHYSQQMAQQVRFPTDTL----QELLDVHAVCEREAIAVF----ME 369
LAQ E + +Q +QQ+A++ + TL Q L++ A ER + V +
Sbjct: 2338 LAQ-EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2396
Query: 370 YSFKDKSQEFQKKLVDTMEK--------KKEDFVLQNEEASAKYCQAELKRLSELLTESI 421
++ +Q F+K+ + EK +++ ++Q E + + +RL E + E
Sbjct: 2397 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE-- 2454
Query: 422 SRGTFFVPGGHNIYLEAKK-KIEQDYTLVPRKGVKADEVLQS-FLQSQVVIEESILQSDK 479
LE +K K++Q+ L+ K + V Q LQ +++S L
Sbjct: 2455 --------------LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2500
Query: 480 ALTAGEKAIAAKQAK------KEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKK 533
+L E+ I ++AK E A+ +Q Q++++QQ ME + + ++ + +++
Sbjct: 2501 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ--MEQERQRLVASMEEARRR 2558
Query: 534 MERERENYMRELRKM--LSHKMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENEEPS 591
E R+ ++ L + + EELL EE RL+EQ++ E + +
Sbjct: 2559 QHEAEEGVRRKQEELQQLEQQRRQQEELLA-----------EENQRLREQLQLLEEQHRA 2607
Query: 592 VFSQILDVAGSIFIA--ALPGAAKLVD 616
+ +V S A LP +D
Sbjct: 2608 ALAHSEEVTASQVAATKTLPNGRDALD 2634
Score = 47.4 bits (111), Expect = 4e-05
Identities = 63/291 (21%), Positives = 128/291 (43%), Gaps = 47/291 (16%)
Query: 311 LENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCEREAIAVFMEY 370
+E A V A+ E + QRA Q +++R + + L V + V +E
Sbjct: 1515 VELASRVKAEAEAAREKQRAL-----QALEELRLQAEEAERRLRQAEVERARQVQVALET 1569
Query: 371 SFKDKSQEFQKKLVDTMEKKKE-DFVLQNEEASAKYCQAELKRLSELLTESISRGTFFVP 429
+ + E Q K EK + + LQ E + + E +R ++ E+
Sbjct: 1570 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA--------- 1620
Query: 430 GGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAIA 489
EA++++E R +KA+E L+ LQ++ V A +K++A
Sbjct: 1621 --ERAREEAERELE-------RWQLKANEALRLRLQAEEV-------------AQQKSLA 1658
Query: 490 AKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERERENYMRELRKML 549
+A+K+ E E+E R++ K ++Q + +E + QE +E++R+ ++ L
Sbjct: 1659 QAEAEKQKEEAERE-ARRRGKAEEQAVRQRELAEQE--------LEKQRQLAEGTAQQRL 1709
Query: 550 SHKMKVLE-ELLTEGFKEIFESLNEEINRLKEQIEAAENEEPSVFSQILDV 599
+ + +++ TE ++ + L EE+ RL+ + AA + + +++ V
Sbjct: 1710 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1760
Score = 41.6 bits (96), Expect = 0.002
Identities = 62/316 (19%), Positives = 132/316 (41%), Gaps = 38/316 (12%)
Query: 296 VETYLDAINSGATPCLENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDV 355
+E L I S A E+ + Q E AA QR + + ++ R + +Q+ L
Sbjct: 1944 LELELGRIRSNA----EDTLRSKEQAELEAARQR---QLAAEEERRRREAEERVQKSLAA 1996
Query: 356 HAVCEREAIAVFMEYSFKDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSE 415
R+ A E E ++L + E++ + +EA+ K QAE K +
Sbjct: 1997 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2056
Query: 416 LLTESISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKAD-------EVLQSFLQSQV 468
+ + E ++ ++Q+ +++ + +A+ E ++ +Q++
Sbjct: 2057 AVQQKEQ--------------ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2102
Query: 469 VIEESILQSDKALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIA 528
+S Q ++A + A QA+ +A ++L ++ ++E + +A++ + ++
Sbjct: 2103 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ--- 2159
Query: 529 QLKKKMERERENYMRELRKMLSHKMKVLEELLT-----EGFKEIFESLNEEINRLKEQIE 583
K+ + E E + + + L K +V +EL T E L+EE+ RLK +
Sbjct: 2160 --KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT 2217
Query: 584 AAENEEPSVFSQILDV 599
A + V ++ V
Sbjct: 2218 EAARQRSQVEEELFSV 2233
Score = 40.0 bits (92), Expect = 0.007
Identities = 32/125 (25%), Positives = 61/125 (48%), Gaps = 8/125 (6%)
Query: 472 ESILQSDKALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQE--RSFQENIAQ 529
E+ L+ + L A A A QA++EA E +Q + + + ++ ++AQ+ RS QE + Q
Sbjct: 1366 EAALEKQRQL-AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ 1424
Query: 530 LKKKMERERENYMRELRKMLSHKMKVLEE-----LLTEGFKEIFESLNEEINRLKEQIEA 584
L++ E E + R+ ++++ EE L E + E+ L+ + E
Sbjct: 1425 LRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEE 1484
Query: 585 AENEE 589
AE ++
Sbjct: 1485 AEAQK 1489
Score = 38.5 bits (88), Expect = 0.019
Identities = 58/285 (20%), Positives = 121/285 (42%), Gaps = 43/285 (15%)
Query: 319 AQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCEREAIAVFMEYSFKDKSQE 378
A+ + AA ++ Q+ A++ + L++ A E E F E + + K+Q
Sbjct: 2127 ARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA--EMEKHKKFAEQTLRQKAQV 2184
Query: 379 FQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLTES------ISRGTFFVPGGH 432
Q+ ++ L+ + EL+RL TE+ + F V
Sbjct: 2185 EQELTTLRLQ-------LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV---- 2233
Query: 433 NIYLEAKKKIEQDYTLVPRKGVKAD-EVLQSFLQSQVVIEESILQSDKALTAGEKAIAAK 491
+ +E K++ R + D + Q FLQ EE+ A A ++AA+
Sbjct: 2234 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQ-----EEAEKMKQVAEEAARLSVAAQ 2288
Query: 492 QAKKEAAEKEQELLRQK-------QKEQQQMMEAQERSFQENIAQLKKKMERERENYMRE 544
+A + E++L +Q+ +++ Q + EA + + Q +K++ +E+ ++E
Sbjct: 2289 EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQE 2348
Query: 545 LRKMLSHKMKVLEELLTEGFKEIFES-------LNEEINRLKEQI 582
++ ++ ++ EE T+GF+ E+ ++ E RLK ++
Sbjct: 2349 DKEQMAQQL--AEE--TQGFQRTLEAERQRQLEMSAEAERLKLRV 2389
Score = 37.7 bits (86), Expect = 0.033
Identities = 68/293 (23%), Positives = 117/293 (39%), Gaps = 52/293 (17%)
Query: 318 LAQCENSAAVQRAANHYSQQMAQQ---VRFPTDTLQ-----ELLDVH-AVCEREAIAVFM 368
LA+ E Q A Q++A + +R +T Q +LL+ A +REA A
Sbjct: 1689 LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA-- 1746
Query: 369 EYSFKDKSQEFQKKLVDTMEK---------KKEDFVLQNEEASAKYCQAELKRLSELLTE 419
K QE + +L + + E+ E S + +AE R EL E
Sbjct: 1747 ----TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1802
Query: 420 SISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDK 479
+ + EAK++ + R+ +A+ VL L + I ++ +
Sbjct: 1803 AARLRA--------LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA-------IGEATR 1847
Query: 480 ALTAGEKAIAAKQAKKEAAEK--EQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERE 537
T E A+ K+A+ E + E E ++++ E+Q + +E +AQL+K + E
Sbjct: 1848 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD--IEERLAQLRKASDSE 1905
Query: 538 RENYMRELRKMLSHKMKVLEELLTEGFKEIFE-------SLNEEINRLKEQIE 583
E + L + +V EE+L K FE L E+ R++ E
Sbjct: 1906 LERQKGLVEDTLRQRRQVEEEIL--ALKASFEKAAAGKAELELELGRIRSNAE 1956
Score = 36.2 bits (82), Expect = 0.095
Identities = 38/158 (24%), Positives = 77/158 (48%), Gaps = 13/158 (8%)
Query: 437 EAKKKIEQDYTLVPRKGVKAD-EVLQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAKK 495
E+++K + + L R VKA+ E + ++ +EE LQ+++A E+ + +QA+
Sbjct: 1506 ESQRKRQAEVELASR--VKAEAEAAREKQRALQALEELRLQAEEA----ERRL--RQAEV 1557
Query: 496 EAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERER--ENYMRELRKMLSHKM 553
E A + Q L Q+ + ++++ SF E AQL++ ++ E +RE + + +
Sbjct: 1558 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1617
Query: 554 KVLEELLTEGFKEI--FESLNEEINRLKEQIEAAENEE 589
E E +E+ ++ E RL+ Q E ++
Sbjct: 1618 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1655
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 50.1 bits (118), Expect = 6e-06
Identities = 73/327 (22%), Positives = 139/327 (42%), Gaps = 58/327 (17%)
Query: 318 LAQCENSAAVQRAANHYSQQMAQQVRFPTDTL----QELLDVHAVCEREAIAVF----ME 369
LAQ E + +Q +QQ+A++ + TL Q L++ A ER + V +
Sbjct: 2342 LAQ-EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2400
Query: 370 YSFKDKSQEFQKKLVDTMEK--------KKEDFVLQNEEASAKYCQAELKRLSELLTESI 421
++ +Q F+K+ + EK +++ ++Q E + + +RL E + E
Sbjct: 2401 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE-- 2458
Query: 422 SRGTFFVPGGHNIYLEAKK-KIEQDYTLVPRKGVKADEVLQS-FLQSQVVIEESILQSDK 479
LE +K K++Q+ L+ K + V Q LQ +++S L
Sbjct: 2459 --------------LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2504
Query: 480 ALTAGEKAIAAKQAK------KEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKK 533
+L E+ I ++AK E A+ +Q Q++++QQ ME + + ++ + +++
Sbjct: 2505 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ--MEQERQRLVASMEEARRR 2562
Query: 534 MERERENYMRELRKM--LSHKMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENEEPS 591
E R+ ++ L + + EELL EE RL+EQ++ E + +
Sbjct: 2563 QHEAEEGVRRKQEELQQLEQQRRQQEELLA-----------EENQRLREQLQLLEEQHRA 2611
Query: 592 VFSQILDVAGSIFIA--ALPGAAKLVD 616
+ +V S A LP +D
Sbjct: 2612 ALAHSEEVTASQVAATKTLPNGRDALD 2638
Score = 47.4 bits (111), Expect = 4e-05
Identities = 63/291 (21%), Positives = 128/291 (43%), Gaps = 47/291 (16%)
Query: 311 LENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCEREAIAVFMEY 370
+E A V A+ E + QRA Q +++R + + L V + V +E
Sbjct: 1519 VELASRVKAEAEAAREKQRAL-----QALEELRLQAEEAERRLRQAEVERARQVQVALET 1573
Query: 371 SFKDKSQEFQKKLVDTMEKKKE-DFVLQNEEASAKYCQAELKRLSELLTESISRGTFFVP 429
+ + E Q K EK + + LQ E + + E +R ++ E+
Sbjct: 1574 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA--------- 1624
Query: 430 GGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAIA 489
EA++++E R +KA+E L+ LQ++ V A +K++A
Sbjct: 1625 --ERAREEAERELE-------RWQLKANEALRLRLQAEEV-------------AQQKSLA 1662
Query: 490 AKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERERENYMRELRKML 549
+A+K+ E E+E R++ K ++Q + +E + QE +E++R+ ++ L
Sbjct: 1663 QAEAEKQKEEAERE-ARRRGKAEEQAVRQRELAEQE--------LEKQRQLAEGTAQQRL 1713
Query: 550 SHKMKVLE-ELLTEGFKEIFESLNEEINRLKEQIEAAENEEPSVFSQILDV 599
+ + +++ TE ++ + L EE+ RL+ + AA + + +++ V
Sbjct: 1714 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1764
Score = 41.6 bits (96), Expect = 0.002
Identities = 62/316 (19%), Positives = 132/316 (41%), Gaps = 38/316 (12%)
Query: 296 VETYLDAINSGATPCLENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDV 355
+E L I S A E+ + Q E AA QR + + ++ R + +Q+ L
Sbjct: 1948 LELELGRIRSNA----EDTLRSKEQAELEAARQR---QLAAEEERRRREAEERVQKSLAA 2000
Query: 356 HAVCEREAIAVFMEYSFKDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSE 415
R+ A E E ++L + E++ + +EA+ K QAE K +
Sbjct: 2001 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2060
Query: 416 LLTESISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKAD-------EVLQSFLQSQV 468
+ + E ++ ++Q+ +++ + +A+ E ++ +Q++
Sbjct: 2061 AVQQKEQ--------------ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2106
Query: 469 VIEESILQSDKALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIA 528
+S Q ++A + A QA+ +A ++L ++ ++E + +A++ + ++
Sbjct: 2107 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ--- 2163
Query: 529 QLKKKMERERENYMRELRKMLSHKMKVLEELLT-----EGFKEIFESLNEEINRLKEQIE 583
K+ + E E + + + L K +V +EL T E L+EE+ RLK +
Sbjct: 2164 --KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT 2221
Query: 584 AAENEEPSVFSQILDV 599
A + V ++ V
Sbjct: 2222 EAARQRSQVEEELFSV 2237
Score = 40.0 bits (92), Expect = 0.007
Identities = 32/125 (25%), Positives = 61/125 (48%), Gaps = 8/125 (6%)
Query: 472 ESILQSDKALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQE--RSFQENIAQ 529
E+ L+ + L A A A QA++EA E +Q + + + ++ ++AQ+ RS QE + Q
Sbjct: 1370 EAALEKQRQL-AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ 1428
Query: 530 LKKKMERERENYMRELRKMLSHKMKVLEE-----LLTEGFKEIFESLNEEINRLKEQIEA 584
L++ E E + R+ ++++ EE L E + E+ L+ + E
Sbjct: 1429 LRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEE 1488
Query: 585 AENEE 589
AE ++
Sbjct: 1489 AEAQK 1493
Score = 38.5 bits (88), Expect = 0.019
Identities = 58/285 (20%), Positives = 121/285 (42%), Gaps = 43/285 (15%)
Query: 319 AQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCEREAIAVFMEYSFKDKSQE 378
A+ + AA ++ Q+ A++ + L++ A E E F E + + K+Q
Sbjct: 2131 ARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA--EMEKHKKFAEQTLRQKAQV 2188
Query: 379 FQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLTES------ISRGTFFVPGGH 432
Q+ ++ L+ + EL+RL TE+ + F V
Sbjct: 2189 EQELTTLRLQ-------LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV---- 2237
Query: 433 NIYLEAKKKIEQDYTLVPRKGVKAD-EVLQSFLQSQVVIEESILQSDKALTAGEKAIAAK 491
+ +E K++ R + D + Q FLQ EE+ A A ++AA+
Sbjct: 2238 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQ-----EEAEKMKQVAEEAARLSVAAQ 2292
Query: 492 QAKKEAAEKEQELLRQK-------QKEQQQMMEAQERSFQENIAQLKKKMERERENYMRE 544
+A + E++L +Q+ +++ Q + EA + + Q +K++ +E+ ++E
Sbjct: 2293 EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQE 2352
Query: 545 LRKMLSHKMKVLEELLTEGFKEIFES-------LNEEINRLKEQI 582
++ ++ ++ EE T+GF+ E+ ++ E RLK ++
Sbjct: 2353 DKEQMAQQL--AEE--TQGFQRTLEAERQRQLEMSAEAERLKLRV 2393
Score = 37.7 bits (86), Expect = 0.033
Identities = 68/293 (23%), Positives = 117/293 (39%), Gaps = 52/293 (17%)
Query: 318 LAQCENSAAVQRAANHYSQQMAQQ---VRFPTDTLQ-----ELLDVH-AVCEREAIAVFM 368
LA+ E Q A Q++A + +R +T Q +LL+ A +REA A
Sbjct: 1693 LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA-- 1750
Query: 369 EYSFKDKSQEFQKKLVDTMEK---------KKEDFVLQNEEASAKYCQAELKRLSELLTE 419
K QE + +L + + E+ E S + +AE R EL E
Sbjct: 1751 ----TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1806
Query: 420 SISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDK 479
+ + EAK++ + R+ +A+ VL L + I ++ +
Sbjct: 1807 AARLRA--------LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA-------IGEATR 1851
Query: 480 ALTAGEKAIAAKQAKKEAAEK--EQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERE 537
T E A+ K+A+ E + E E ++++ E+Q + +E +AQL+K + E
Sbjct: 1852 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD--IEERLAQLRKASDSE 1909
Query: 538 RENYMRELRKMLSHKMKVLEELLTEGFKEIFE-------SLNEEINRLKEQIE 583
E + L + +V EE+L K FE L E+ R++ E
Sbjct: 1910 LERQKGLVEDTLRQRRQVEEEIL--ALKASFEKAAAGKAELELELGRIRSNAE 1960
Score = 36.2 bits (82), Expect = 0.095
Identities = 38/158 (24%), Positives = 77/158 (48%), Gaps = 13/158 (8%)
Query: 437 EAKKKIEQDYTLVPRKGVKAD-EVLQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAKK 495
E+++K + + L R VKA+ E + ++ +EE LQ+++A E+ + +QA+
Sbjct: 1510 ESQRKRQAEVELASR--VKAEAEAAREKQRALQALEELRLQAEEA----ERRL--RQAEV 1561
Query: 496 EAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERER--ENYMRELRKMLSHKM 553
E A + Q L Q+ + ++++ SF E AQL++ ++ E +RE + + +
Sbjct: 1562 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1621
Query: 554 KVLEELLTEGFKEI--FESLNEEINRLKEQIEAAENEE 589
E E +E+ ++ E RL+ Q E ++
Sbjct: 1622 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1659
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 50.1 bits (118), Expect = 6e-06
Identities = 73/327 (22%), Positives = 139/327 (42%), Gaps = 58/327 (17%)
Query: 318 LAQCENSAAVQRAANHYSQQMAQQVRFPTDTL----QELLDVHAVCEREAIAVF----ME 369
LAQ E + +Q +QQ+A++ + TL Q L++ A ER + V +
Sbjct: 2338 LAQ-EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2396
Query: 370 YSFKDKSQEFQKKLVDTMEK--------KKEDFVLQNEEASAKYCQAELKRLSELLTESI 421
++ +Q F+K+ + EK +++ ++Q E + + +RL E + E
Sbjct: 2397 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE-- 2454
Query: 422 SRGTFFVPGGHNIYLEAKK-KIEQDYTLVPRKGVKADEVLQS-FLQSQVVIEESILQSDK 479
LE +K K++Q+ L+ K + V Q LQ +++S L
Sbjct: 2455 --------------LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2500
Query: 480 ALTAGEKAIAAKQAK------KEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKK 533
+L E+ I ++AK E A+ +Q Q++++QQ ME + + ++ + +++
Sbjct: 2501 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ--MEQERQRLVASMEEARRR 2558
Query: 534 MERERENYMRELRKM--LSHKMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENEEPS 591
E R+ ++ L + + EELL EE RL+EQ++ E + +
Sbjct: 2559 QHEAEEGVRRKQEELQQLEQQRRQQEELLA-----------EENQRLREQLQLLEEQHRA 2607
Query: 592 VFSQILDVAGSIFIA--ALPGAAKLVD 616
+ +V S A LP +D
Sbjct: 2608 ALAHSEEVTASQVAATKTLPNGRDALD 2634
Score = 47.4 bits (111), Expect = 4e-05
Identities = 63/291 (21%), Positives = 128/291 (43%), Gaps = 47/291 (16%)
Query: 311 LENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCEREAIAVFMEY 370
+E A V A+ E + QRA Q +++R + + L V + V +E
Sbjct: 1515 VELASRVKAEAEAAREKQRAL-----QALEELRLQAEEAERRLRQAEVERARQVQVALET 1569
Query: 371 SFKDKSQEFQKKLVDTMEKKKE-DFVLQNEEASAKYCQAELKRLSELLTESISRGTFFVP 429
+ + E Q K EK + + LQ E + + E +R ++ E+
Sbjct: 1570 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA--------- 1620
Query: 430 GGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAIA 489
EA++++E R +KA+E L+ LQ++ V A +K++A
Sbjct: 1621 --ERAREEAERELE-------RWQLKANEALRLRLQAEEV-------------AQQKSLA 1658
Query: 490 AKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERERENYMRELRKML 549
+A+K+ E E+E R++ K ++Q + +E + QE +E++R+ ++ L
Sbjct: 1659 QAEAEKQKEEAERE-ARRRGKAEEQAVRQRELAEQE--------LEKQRQLAEGTAQQRL 1709
Query: 550 SHKMKVLE-ELLTEGFKEIFESLNEEINRLKEQIEAAENEEPSVFSQILDV 599
+ + +++ TE ++ + L EE+ RL+ + AA + + +++ V
Sbjct: 1710 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1760
Score = 41.6 bits (96), Expect = 0.002
Identities = 62/316 (19%), Positives = 132/316 (41%), Gaps = 38/316 (12%)
Query: 296 VETYLDAINSGATPCLENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDV 355
+E L I S A E+ + Q E AA QR + + ++ R + +Q+ L
Sbjct: 1944 LELELGRIRSNA----EDTLRSKEQAELEAARQR---QLAAEEERRRREAEERVQKSLAA 1996
Query: 356 HAVCEREAIAVFMEYSFKDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSE 415
R+ A E E ++L + E++ + +EA+ K QAE K +
Sbjct: 1997 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2056
Query: 416 LLTESISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKAD-------EVLQSFLQSQV 468
+ + E ++ ++Q+ +++ + +A+ E ++ +Q++
Sbjct: 2057 AVQQKEQ--------------ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2102
Query: 469 VIEESILQSDKALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIA 528
+S Q ++A + A QA+ +A ++L ++ ++E + +A++ + ++
Sbjct: 2103 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ--- 2159
Query: 529 QLKKKMERERENYMRELRKMLSHKMKVLEELLT-----EGFKEIFESLNEEINRLKEQIE 583
K+ + E E + + + L K +V +EL T E L+EE+ RLK +
Sbjct: 2160 --KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT 2217
Query: 584 AAENEEPSVFSQILDV 599
A + V ++ V
Sbjct: 2218 EAARQRSQVEEELFSV 2233
Score = 40.0 bits (92), Expect = 0.007
Identities = 32/125 (25%), Positives = 61/125 (48%), Gaps = 8/125 (6%)
Query: 472 ESILQSDKALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQE--RSFQENIAQ 529
E+ L+ + L A A A QA++EA E +Q + + + ++ ++AQ+ RS QE + Q
Sbjct: 1366 EAALEKQRQL-AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ 1424
Query: 530 LKKKMERERENYMRELRKMLSHKMKVLEE-----LLTEGFKEIFESLNEEINRLKEQIEA 584
L++ E E + R+ ++++ EE L E + E+ L+ + E
Sbjct: 1425 LRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEE 1484
Query: 585 AENEE 589
AE ++
Sbjct: 1485 AEAQK 1489
Score = 38.5 bits (88), Expect = 0.019
Identities = 58/285 (20%), Positives = 121/285 (42%), Gaps = 43/285 (15%)
Query: 319 AQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCEREAIAVFMEYSFKDKSQE 378
A+ + AA ++ Q+ A++ + L++ A E E F E + + K+Q
Sbjct: 2127 ARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA--EMEKHKKFAEQTLRQKAQV 2184
Query: 379 FQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLTES------ISRGTFFVPGGH 432
Q+ ++ L+ + EL+RL TE+ + F V
Sbjct: 2185 EQELTTLRLQ-------LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV---- 2233
Query: 433 NIYLEAKKKIEQDYTLVPRKGVKAD-EVLQSFLQSQVVIEESILQSDKALTAGEKAIAAK 491
+ +E K++ R + D + Q FLQ EE+ A A ++AA+
Sbjct: 2234 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQ-----EEAEKMKQVAEEAARLSVAAQ 2288
Query: 492 QAKKEAAEKEQELLRQK-------QKEQQQMMEAQERSFQENIAQLKKKMERERENYMRE 544
+A + E++L +Q+ +++ Q + EA + + Q +K++ +E+ ++E
Sbjct: 2289 EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQE 2348
Query: 545 LRKMLSHKMKVLEELLTEGFKEIFES-------LNEEINRLKEQI 582
++ ++ ++ EE T+GF+ E+ ++ E RLK ++
Sbjct: 2349 DKEQMAQQL--AEE--TQGFQRTLEAERQRQLEMSAEAERLKLRV 2389
Score = 37.7 bits (86), Expect = 0.033
Identities = 68/293 (23%), Positives = 117/293 (39%), Gaps = 52/293 (17%)
Query: 318 LAQCENSAAVQRAANHYSQQMAQQ---VRFPTDTLQ-----ELLDVH-AVCEREAIAVFM 368
LA+ E Q A Q++A + +R +T Q +LL+ A +REA A
Sbjct: 1689 LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA-- 1746
Query: 369 EYSFKDKSQEFQKKLVDTMEK---------KKEDFVLQNEEASAKYCQAELKRLSELLTE 419
K QE + +L + + E+ E S + +AE R EL E
Sbjct: 1747 ----TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1802
Query: 420 SISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDK 479
+ + EAK++ + R+ +A+ VL L + I ++ +
Sbjct: 1803 AARLRA--------LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA-------IGEATR 1847
Query: 480 ALTAGEKAIAAKQAKKEAAEK--EQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERE 537
T E A+ K+A+ E + E E ++++ E+Q + +E +AQL+K + E
Sbjct: 1848 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD--IEERLAQLRKASDSE 1905
Query: 538 RENYMRELRKMLSHKMKVLEELLTEGFKEIFE-------SLNEEINRLKEQIE 583
E + L + +V EE+L K FE L E+ R++ E
Sbjct: 1906 LERQKGLVEDTLRQRRQVEEEIL--ALKASFEKAAAGKAELELELGRIRSNAE 1956
Score = 36.2 bits (82), Expect = 0.095
Identities = 38/158 (24%), Positives = 77/158 (48%), Gaps = 13/158 (8%)
Query: 437 EAKKKIEQDYTLVPRKGVKAD-EVLQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAKK 495
E+++K + + L R VKA+ E + ++ +EE LQ+++A E+ + +QA+
Sbjct: 1506 ESQRKRQAEVELASR--VKAEAEAAREKQRALQALEELRLQAEEA----ERRL--RQAEV 1557
Query: 496 EAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERER--ENYMRELRKMLSHKM 553
E A + Q L Q+ + ++++ SF E AQL++ ++ E +RE + + +
Sbjct: 1558 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1617
Query: 554 KVLEELLTEGFKEI--FESLNEEINRLKEQIEAAENEE 589
E E +E+ ++ E RL+ Q E ++
Sbjct: 1618 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1655
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 50.1 bits (118), Expect = 6e-06
Identities = 73/327 (22%), Positives = 139/327 (42%), Gaps = 58/327 (17%)
Query: 318 LAQCENSAAVQRAANHYSQQMAQQVRFPTDTL----QELLDVHAVCEREAIAVF----ME 369
LAQ E + +Q +QQ+A++ + TL Q L++ A ER + V +
Sbjct: 2306 LAQ-EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2364
Query: 370 YSFKDKSQEFQKKLVDTMEK--------KKEDFVLQNEEASAKYCQAELKRLSELLTESI 421
++ +Q F+K+ + EK +++ ++Q E + + +RL E + E
Sbjct: 2365 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE-- 2422
Query: 422 SRGTFFVPGGHNIYLEAKK-KIEQDYTLVPRKGVKADEVLQS-FLQSQVVIEESILQSDK 479
LE +K K++Q+ L+ K + V Q LQ +++S L
Sbjct: 2423 --------------LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2468
Query: 480 ALTAGEKAIAAKQAK------KEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKK 533
+L E+ I ++AK E A+ +Q Q++++QQ ME + + ++ + +++
Sbjct: 2469 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ--MEQERQRLVASMEEARRR 2526
Query: 534 MERERENYMRELRKM--LSHKMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENEEPS 591
E R+ ++ L + + EELL EE RL+EQ++ E + +
Sbjct: 2527 QHEAEEGVRRKQEELQQLEQQRRQQEELLA-----------EENQRLREQLQLLEEQHRA 2575
Query: 592 VFSQILDVAGSIFIA--ALPGAAKLVD 616
+ +V S A LP +D
Sbjct: 2576 ALAHSEEVTASQVAATKTLPNGRDALD 2602
Score = 47.4 bits (111), Expect = 4e-05
Identities = 63/291 (21%), Positives = 128/291 (43%), Gaps = 47/291 (16%)
Query: 311 LENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCEREAIAVFMEY 370
+E A V A+ E + QRA Q +++R + + L V + V +E
Sbjct: 1483 VELASRVKAEAEAAREKQRAL-----QALEELRLQAEEAERRLRQAEVERARQVQVALET 1537
Query: 371 SFKDKSQEFQKKLVDTMEKKKE-DFVLQNEEASAKYCQAELKRLSELLTESISRGTFFVP 429
+ + E Q K EK + + LQ E + + E +R ++ E+
Sbjct: 1538 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA--------- 1588
Query: 430 GGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAIA 489
EA++++E R +KA+E L+ LQ++ V A +K++A
Sbjct: 1589 --ERAREEAERELE-------RWQLKANEALRLRLQAEEV-------------AQQKSLA 1626
Query: 490 AKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERERENYMRELRKML 549
+A+K+ E E+E R++ K ++Q + +E + QE +E++R+ ++ L
Sbjct: 1627 QAEAEKQKEEAERE-ARRRGKAEEQAVRQRELAEQE--------LEKQRQLAEGTAQQRL 1677
Query: 550 SHKMKVLE-ELLTEGFKEIFESLNEEINRLKEQIEAAENEEPSVFSQILDV 599
+ + +++ TE ++ + L EE+ RL+ + AA + + +++ V
Sbjct: 1678 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1728
Score = 41.6 bits (96), Expect = 0.002
Identities = 62/316 (19%), Positives = 132/316 (41%), Gaps = 38/316 (12%)
Query: 296 VETYLDAINSGATPCLENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDV 355
+E L I S A E+ + Q E AA QR + + ++ R + +Q+ L
Sbjct: 1912 LELELGRIRSNA----EDTLRSKEQAELEAARQR---QLAAEEERRRREAEERVQKSLAA 1964
Query: 356 HAVCEREAIAVFMEYSFKDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSE 415
R+ A E E ++L + E++ + +EA+ K QAE K +
Sbjct: 1965 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2024
Query: 416 LLTESISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKAD-------EVLQSFLQSQV 468
+ + E ++ ++Q+ +++ + +A+ E ++ +Q++
Sbjct: 2025 AVQQKEQ--------------ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2070
Query: 469 VIEESILQSDKALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIA 528
+S Q ++A + A QA+ +A ++L ++ ++E + +A++ + ++
Sbjct: 2071 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ--- 2127
Query: 529 QLKKKMERERENYMRELRKMLSHKMKVLEELLT-----EGFKEIFESLNEEINRLKEQIE 583
K+ + E E + + + L K +V +EL T E L+EE+ RLK +
Sbjct: 2128 --KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT 2185
Query: 584 AAENEEPSVFSQILDV 599
A + V ++ V
Sbjct: 2186 EAARQRSQVEEELFSV 2201
Score = 40.0 bits (92), Expect = 0.007
Identities = 32/125 (25%), Positives = 61/125 (48%), Gaps = 8/125 (6%)
Query: 472 ESILQSDKALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQE--RSFQENIAQ 529
E+ L+ + L A A A QA++EA E +Q + + + ++ ++AQ+ RS QE + Q
Sbjct: 1334 EAALEKQRQL-AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ 1392
Query: 530 LKKKMERERENYMRELRKMLSHKMKVLEE-----LLTEGFKEIFESLNEEINRLKEQIEA 584
L++ E E + R+ ++++ EE L E + E+ L+ + E
Sbjct: 1393 LRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEE 1452
Query: 585 AENEE 589
AE ++
Sbjct: 1453 AEAQK 1457
Score = 38.5 bits (88), Expect = 0.019
Identities = 58/285 (20%), Positives = 121/285 (42%), Gaps = 43/285 (15%)
Query: 319 AQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCEREAIAVFMEYSFKDKSQE 378
A+ + AA ++ Q+ A++ + L++ A E E F E + + K+Q
Sbjct: 2095 ARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA--EMEKHKKFAEQTLRQKAQV 2152
Query: 379 FQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLTES------ISRGTFFVPGGH 432
Q+ ++ L+ + EL+RL TE+ + F V
Sbjct: 2153 EQELTTLRLQ-------LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV---- 2201
Query: 433 NIYLEAKKKIEQDYTLVPRKGVKAD-EVLQSFLQSQVVIEESILQSDKALTAGEKAIAAK 491
+ +E K++ R + D + Q FLQ EE+ A A ++AA+
Sbjct: 2202 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQ-----EEAEKMKQVAEEAARLSVAAQ 2256
Query: 492 QAKKEAAEKEQELLRQK-------QKEQQQMMEAQERSFQENIAQLKKKMERERENYMRE 544
+A + E++L +Q+ +++ Q + EA + + Q +K++ +E+ ++E
Sbjct: 2257 EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQE 2316
Query: 545 LRKMLSHKMKVLEELLTEGFKEIFES-------LNEEINRLKEQI 582
++ ++ ++ EE T+GF+ E+ ++ E RLK ++
Sbjct: 2317 DKEQMAQQL--AEE--TQGFQRTLEAERQRQLEMSAEAERLKLRV 2357
Score = 37.7 bits (86), Expect = 0.033
Identities = 68/293 (23%), Positives = 117/293 (39%), Gaps = 52/293 (17%)
Query: 318 LAQCENSAAVQRAANHYSQQMAQQ---VRFPTDTLQ-----ELLDVH-AVCEREAIAVFM 368
LA+ E Q A Q++A + +R +T Q +LL+ A +REA A
Sbjct: 1657 LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA-- 1714
Query: 369 EYSFKDKSQEFQKKLVDTMEK---------KKEDFVLQNEEASAKYCQAELKRLSELLTE 419
K QE + +L + + E+ E S + +AE R EL E
Sbjct: 1715 ----TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1770
Query: 420 SISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDK 479
+ + EAK++ + R+ +A+ VL L + I ++ +
Sbjct: 1771 AARLRA--------LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA-------IGEATR 1815
Query: 480 ALTAGEKAIAAKQAKKEAAEK--EQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERE 537
T E A+ K+A+ E + E E ++++ E+Q + +E +AQL+K + E
Sbjct: 1816 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD--IEERLAQLRKASDSE 1873
Query: 538 RENYMRELRKMLSHKMKVLEELLTEGFKEIFE-------SLNEEINRLKEQIE 583
E + L + +V EE+L K FE L E+ R++ E
Sbjct: 1874 LERQKGLVEDTLRQRRQVEEEIL--ALKASFEKAAAGKAELELELGRIRSNAE 1924
Score = 36.2 bits (82), Expect = 0.095
Identities = 38/158 (24%), Positives = 77/158 (48%), Gaps = 13/158 (8%)
Query: 437 EAKKKIEQDYTLVPRKGVKAD-EVLQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAKK 495
E+++K + + L R VKA+ E + ++ +EE LQ+++A E+ + +QA+
Sbjct: 1474 ESQRKRQAEVELASR--VKAEAEAAREKQRALQALEELRLQAEEA----ERRL--RQAEV 1525
Query: 496 EAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERER--ENYMRELRKMLSHKM 553
E A + Q L Q+ + ++++ SF E AQL++ ++ E +RE + + +
Sbjct: 1526 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1585
Query: 554 KVLEELLTEGFKEI--FESLNEEINRLKEQIEAAENEE 589
E E +E+ ++ E RL+ Q E ++
Sbjct: 1586 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1623
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 50.1 bits (118), Expect = 6e-06
Identities = 73/327 (22%), Positives = 139/327 (42%), Gaps = 58/327 (17%)
Query: 318 LAQCENSAAVQRAANHYSQQMAQQVRFPTDTL----QELLDVHAVCEREAIAVF----ME 369
LAQ E + +Q +QQ+A++ + TL Q L++ A ER + V +
Sbjct: 2475 LAQ-EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2533
Query: 370 YSFKDKSQEFQKKLVDTMEK--------KKEDFVLQNEEASAKYCQAELKRLSELLTESI 421
++ +Q F+K+ + EK +++ ++Q E + + +RL E + E
Sbjct: 2534 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE-- 2591
Query: 422 SRGTFFVPGGHNIYLEAKK-KIEQDYTLVPRKGVKADEVLQS-FLQSQVVIEESILQSDK 479
LE +K K++Q+ L+ K + V Q LQ +++S L
Sbjct: 2592 --------------LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2637
Query: 480 ALTAGEKAIAAKQAK------KEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKK 533
+L E+ I ++AK E A+ +Q Q++++QQ ME + + ++ + +++
Sbjct: 2638 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ--MEQERQRLVASMEEARRR 2695
Query: 534 MERERENYMRELRKM--LSHKMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENEEPS 591
E R+ ++ L + + EELL EE RL+EQ++ E + +
Sbjct: 2696 QHEAEEGVRRKQEELQQLEQQRRQQEELLA-----------EENQRLREQLQLLEEQHRA 2744
Query: 592 VFSQILDVAGSIFIA--ALPGAAKLVD 616
+ +V S A LP +D
Sbjct: 2745 ALAHSEEVTASQVAATKTLPNGRDALD 2771
Score = 47.4 bits (111), Expect = 4e-05
Identities = 63/291 (21%), Positives = 128/291 (43%), Gaps = 47/291 (16%)
Query: 311 LENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCEREAIAVFMEY 370
+E A V A+ E + QRA Q +++R + + L V + V +E
Sbjct: 1652 VELASRVKAEAEAAREKQRAL-----QALEELRLQAEEAERRLRQAEVERARQVQVALET 1706
Query: 371 SFKDKSQEFQKKLVDTMEKKKE-DFVLQNEEASAKYCQAELKRLSELLTESISRGTFFVP 429
+ + E Q K EK + + LQ E + + E +R ++ E+
Sbjct: 1707 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA--------- 1757
Query: 430 GGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAIA 489
EA++++E R +KA+E L+ LQ++ V A +K++A
Sbjct: 1758 --ERAREEAERELE-------RWQLKANEALRLRLQAEEV-------------AQQKSLA 1795
Query: 490 AKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERERENYMRELRKML 549
+A+K+ E E+E R++ K ++Q + +E + QE +E++R+ ++ L
Sbjct: 1796 QAEAEKQKEEAERE-ARRRGKAEEQAVRQRELAEQE--------LEKQRQLAEGTAQQRL 1846
Query: 550 SHKMKVLE-ELLTEGFKEIFESLNEEINRLKEQIEAAENEEPSVFSQILDV 599
+ + +++ TE ++ + L EE+ RL+ + AA + + +++ V
Sbjct: 1847 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1897
Score = 41.6 bits (96), Expect = 0.002
Identities = 62/316 (19%), Positives = 132/316 (41%), Gaps = 38/316 (12%)
Query: 296 VETYLDAINSGATPCLENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDV 355
+E L I S A E+ + Q E AA QR + + ++ R + +Q+ L
Sbjct: 2081 LELELGRIRSNA----EDTLRSKEQAELEAARQR---QLAAEEERRRREAEERVQKSLAA 2133
Query: 356 HAVCEREAIAVFMEYSFKDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSE 415
R+ A E E ++L + E++ + +EA+ K QAE K +
Sbjct: 2134 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2193
Query: 416 LLTESISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKAD-------EVLQSFLQSQV 468
+ + E ++ ++Q+ +++ + +A+ E ++ +Q++
Sbjct: 2194 AVQQKEQ--------------ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2239
Query: 469 VIEESILQSDKALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIA 528
+S Q ++A + A QA+ +A ++L ++ ++E + +A++ + ++
Sbjct: 2240 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ--- 2296
Query: 529 QLKKKMERERENYMRELRKMLSHKMKVLEELLT-----EGFKEIFESLNEEINRLKEQIE 583
K+ + E E + + + L K +V +EL T E L+EE+ RLK +
Sbjct: 2297 --KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT 2354
Query: 584 AAENEEPSVFSQILDV 599
A + V ++ V
Sbjct: 2355 EAARQRSQVEEELFSV 2370
Score = 40.0 bits (92), Expect = 0.007
Identities = 32/125 (25%), Positives = 61/125 (48%), Gaps = 8/125 (6%)
Query: 472 ESILQSDKALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQE--RSFQENIAQ 529
E+ L+ + L A A A QA++EA E +Q + + + ++ ++AQ+ RS QE + Q
Sbjct: 1503 EAALEKQRQL-AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ 1561
Query: 530 LKKKMERERENYMRELRKMLSHKMKVLEE-----LLTEGFKEIFESLNEEINRLKEQIEA 584
L++ E E + R+ ++++ EE L E + E+ L+ + E
Sbjct: 1562 LRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEE 1621
Query: 585 AENEE 589
AE ++
Sbjct: 1622 AEAQK 1626
Score = 38.5 bits (88), Expect = 0.019
Identities = 58/285 (20%), Positives = 121/285 (42%), Gaps = 43/285 (15%)
Query: 319 AQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCEREAIAVFMEYSFKDKSQE 378
A+ + AA ++ Q+ A++ + L++ A E E F E + + K+Q
Sbjct: 2264 ARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA--EMEKHKKFAEQTLRQKAQV 2321
Query: 379 FQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLTES------ISRGTFFVPGGH 432
Q+ ++ L+ + EL+RL TE+ + F V
Sbjct: 2322 EQELTTLRLQ-------LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV---- 2370
Query: 433 NIYLEAKKKIEQDYTLVPRKGVKAD-EVLQSFLQSQVVIEESILQSDKALTAGEKAIAAK 491
+ +E K++ R + D + Q FLQ EE+ A A ++AA+
Sbjct: 2371 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQ-----EEAEKMKQVAEEAARLSVAAQ 2425
Query: 492 QAKKEAAEKEQELLRQK-------QKEQQQMMEAQERSFQENIAQLKKKMERERENYMRE 544
+A + E++L +Q+ +++ Q + EA + + Q +K++ +E+ ++E
Sbjct: 2426 EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQE 2485
Query: 545 LRKMLSHKMKVLEELLTEGFKEIFES-------LNEEINRLKEQI 582
++ ++ ++ EE T+GF+ E+ ++ E RLK ++
Sbjct: 2486 DKEQMAQQL--AEE--TQGFQRTLEAERQRQLEMSAEAERLKLRV 2526
Score = 37.7 bits (86), Expect = 0.033
Identities = 68/293 (23%), Positives = 117/293 (39%), Gaps = 52/293 (17%)
Query: 318 LAQCENSAAVQRAANHYSQQMAQQ---VRFPTDTLQ-----ELLDVH-AVCEREAIAVFM 368
LA+ E Q A Q++A + +R +T Q +LL+ A +REA A
Sbjct: 1826 LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA-- 1883
Query: 369 EYSFKDKSQEFQKKLVDTMEK---------KKEDFVLQNEEASAKYCQAELKRLSELLTE 419
K QE + +L + + E+ E S + +AE R EL E
Sbjct: 1884 ----TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1939
Query: 420 SISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDK 479
+ + EAK++ + R+ +A+ VL L + I ++ +
Sbjct: 1940 AARLRA--------LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA-------IGEATR 1984
Query: 480 ALTAGEKAIAAKQAKKEAAEK--EQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERE 537
T E A+ K+A+ E + E E ++++ E+Q + +E +AQL+K + E
Sbjct: 1985 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD--IEERLAQLRKASDSE 2042
Query: 538 RENYMRELRKMLSHKMKVLEELLTEGFKEIFE-------SLNEEINRLKEQIE 583
E + L + +V EE+L K FE L E+ R++ E
Sbjct: 2043 LERQKGLVEDTLRQRRQVEEEIL--ALKASFEKAAAGKAELELELGRIRSNAE 2093
Score = 36.2 bits (82), Expect = 0.095
Identities = 38/158 (24%), Positives = 77/158 (48%), Gaps = 13/158 (8%)
Query: 437 EAKKKIEQDYTLVPRKGVKAD-EVLQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAKK 495
E+++K + + L R VKA+ E + ++ +EE LQ+++A E+ + +QA+
Sbjct: 1643 ESQRKRQAEVELASR--VKAEAEAAREKQRALQALEELRLQAEEA----ERRL--RQAEV 1694
Query: 496 EAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERER--ENYMRELRKMLSHKM 553
E A + Q L Q+ + ++++ SF E AQL++ ++ E +RE + + +
Sbjct: 1695 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1754
Query: 554 KVLEELLTEGFKEI--FESLNEEINRLKEQIEAAENEE 589
E E +E+ ++ E RL+ Q E ++
Sbjct: 1755 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1792
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 50.1 bits (118), Expect = 6e-06
Identities = 73/327 (22%), Positives = 139/327 (42%), Gaps = 58/327 (17%)
Query: 318 LAQCENSAAVQRAANHYSQQMAQQVRFPTDTL----QELLDVHAVCEREAIAVF----ME 369
LAQ E + +Q +QQ+A++ + TL Q L++ A ER + V +
Sbjct: 2316 LAQ-EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2374
Query: 370 YSFKDKSQEFQKKLVDTMEK--------KKEDFVLQNEEASAKYCQAELKRLSELLTESI 421
++ +Q F+K+ + EK +++ ++Q E + + +RL E + E
Sbjct: 2375 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE-- 2432
Query: 422 SRGTFFVPGGHNIYLEAKK-KIEQDYTLVPRKGVKADEVLQS-FLQSQVVIEESILQSDK 479
LE +K K++Q+ L+ K + V Q LQ +++S L
Sbjct: 2433 --------------LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2478
Query: 480 ALTAGEKAIAAKQAK------KEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKK 533
+L E+ I ++AK E A+ +Q Q++++QQ ME + + ++ + +++
Sbjct: 2479 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ--MEQERQRLVASMEEARRR 2536
Query: 534 MERERENYMRELRKM--LSHKMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENEEPS 591
E R+ ++ L + + EELL EE RL+EQ++ E + +
Sbjct: 2537 QHEAEEGVRRKQEELQQLEQQRRQQEELLA-----------EENQRLREQLQLLEEQHRA 2585
Query: 592 VFSQILDVAGSIFIA--ALPGAAKLVD 616
+ +V S A LP +D
Sbjct: 2586 ALAHSEEVTASQVAATKTLPNGRDALD 2612
Score = 47.4 bits (111), Expect = 4e-05
Identities = 63/291 (21%), Positives = 128/291 (43%), Gaps = 47/291 (16%)
Query: 311 LENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCEREAIAVFMEY 370
+E A V A+ E + QRA Q +++R + + L V + V +E
Sbjct: 1493 VELASRVKAEAEAAREKQRAL-----QALEELRLQAEEAERRLRQAEVERARQVQVALET 1547
Query: 371 SFKDKSQEFQKKLVDTMEKKKE-DFVLQNEEASAKYCQAELKRLSELLTESISRGTFFVP 429
+ + E Q K EK + + LQ E + + E +R ++ E+
Sbjct: 1548 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA--------- 1598
Query: 430 GGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAIA 489
EA++++E R +KA+E L+ LQ++ V A +K++A
Sbjct: 1599 --ERAREEAERELE-------RWQLKANEALRLRLQAEEV-------------AQQKSLA 1636
Query: 490 AKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERERENYMRELRKML 549
+A+K+ E E+E R++ K ++Q + +E + QE +E++R+ ++ L
Sbjct: 1637 QAEAEKQKEEAERE-ARRRGKAEEQAVRQRELAEQE--------LEKQRQLAEGTAQQRL 1687
Query: 550 SHKMKVLE-ELLTEGFKEIFESLNEEINRLKEQIEAAENEEPSVFSQILDV 599
+ + +++ TE ++ + L EE+ RL+ + AA + + +++ V
Sbjct: 1688 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1738
Score = 41.6 bits (96), Expect = 0.002
Identities = 62/316 (19%), Positives = 132/316 (41%), Gaps = 38/316 (12%)
Query: 296 VETYLDAINSGATPCLENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDV 355
+E L I S A E+ + Q E AA QR + + ++ R + +Q+ L
Sbjct: 1922 LELELGRIRSNA----EDTLRSKEQAELEAARQR---QLAAEEERRRREAEERVQKSLAA 1974
Query: 356 HAVCEREAIAVFMEYSFKDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSE 415
R+ A E E ++L + E++ + +EA+ K QAE K +
Sbjct: 1975 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2034
Query: 416 LLTESISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKAD-------EVLQSFLQSQV 468
+ + E ++ ++Q+ +++ + +A+ E ++ +Q++
Sbjct: 2035 AVQQKEQ--------------ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2080
Query: 469 VIEESILQSDKALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIA 528
+S Q ++A + A QA+ +A ++L ++ ++E + +A++ + ++
Sbjct: 2081 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ--- 2137
Query: 529 QLKKKMERERENYMRELRKMLSHKMKVLEELLT-----EGFKEIFESLNEEINRLKEQIE 583
K+ + E E + + + L K +V +EL T E L+EE+ RLK +
Sbjct: 2138 --KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT 2195
Query: 584 AAENEEPSVFSQILDV 599
A + V ++ V
Sbjct: 2196 EAARQRSQVEEELFSV 2211
Score = 40.0 bits (92), Expect = 0.007
Identities = 32/125 (25%), Positives = 61/125 (48%), Gaps = 8/125 (6%)
Query: 472 ESILQSDKALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQE--RSFQENIAQ 529
E+ L+ + L A A A QA++EA E +Q + + + ++ ++AQ+ RS QE + Q
Sbjct: 1344 EAALEKQRQL-AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ 1402
Query: 530 LKKKMERERENYMRELRKMLSHKMKVLEE-----LLTEGFKEIFESLNEEINRLKEQIEA 584
L++ E E + R+ ++++ EE L E + E+ L+ + E
Sbjct: 1403 LRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEE 1462
Query: 585 AENEE 589
AE ++
Sbjct: 1463 AEAQK 1467
Score = 38.5 bits (88), Expect = 0.019
Identities = 58/285 (20%), Positives = 121/285 (42%), Gaps = 43/285 (15%)
Query: 319 AQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCEREAIAVFMEYSFKDKSQE 378
A+ + AA ++ Q+ A++ + L++ A E E F E + + K+Q
Sbjct: 2105 ARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA--EMEKHKKFAEQTLRQKAQV 2162
Query: 379 FQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLTES------ISRGTFFVPGGH 432
Q+ ++ L+ + EL+RL TE+ + F V
Sbjct: 2163 EQELTTLRLQ-------LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV---- 2211
Query: 433 NIYLEAKKKIEQDYTLVPRKGVKAD-EVLQSFLQSQVVIEESILQSDKALTAGEKAIAAK 491
+ +E K++ R + D + Q FLQ EE+ A A ++AA+
Sbjct: 2212 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQ-----EEAEKMKQVAEEAARLSVAAQ 2266
Query: 492 QAKKEAAEKEQELLRQK-------QKEQQQMMEAQERSFQENIAQLKKKMERERENYMRE 544
+A + E++L +Q+ +++ Q + EA + + Q +K++ +E+ ++E
Sbjct: 2267 EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQE 2326
Query: 545 LRKMLSHKMKVLEELLTEGFKEIFES-------LNEEINRLKEQI 582
++ ++ ++ EE T+GF+ E+ ++ E RLK ++
Sbjct: 2327 DKEQMAQQL--AEE--TQGFQRTLEAERQRQLEMSAEAERLKLRV 2367
Score = 37.7 bits (86), Expect = 0.033
Identities = 68/293 (23%), Positives = 117/293 (39%), Gaps = 52/293 (17%)
Query: 318 LAQCENSAAVQRAANHYSQQMAQQ---VRFPTDTLQ-----ELLDVH-AVCEREAIAVFM 368
LA+ E Q A Q++A + +R +T Q +LL+ A +REA A
Sbjct: 1667 LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA-- 1724
Query: 369 EYSFKDKSQEFQKKLVDTMEK---------KKEDFVLQNEEASAKYCQAELKRLSELLTE 419
K QE + +L + + E+ E S + +AE R EL E
Sbjct: 1725 ----TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1780
Query: 420 SISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDK 479
+ + EAK++ + R+ +A+ VL L + I ++ +
Sbjct: 1781 AARLRA--------LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA-------IGEATR 1825
Query: 480 ALTAGEKAIAAKQAKKEAAEK--EQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERE 537
T E A+ K+A+ E + E E ++++ E+Q + +E +AQL+K + E
Sbjct: 1826 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD--IEERLAQLRKASDSE 1883
Query: 538 RENYMRELRKMLSHKMKVLEELLTEGFKEIFE-------SLNEEINRLKEQIE 583
E + L + +V EE+L K FE L E+ R++ E
Sbjct: 1884 LERQKGLVEDTLRQRRQVEEEIL--ALKASFEKAAAGKAELELELGRIRSNAE 1934
Score = 36.2 bits (82), Expect = 0.095
Identities = 38/158 (24%), Positives = 77/158 (48%), Gaps = 13/158 (8%)
Query: 437 EAKKKIEQDYTLVPRKGVKAD-EVLQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAKK 495
E+++K + + L R VKA+ E + ++ +EE LQ+++A E+ + +QA+
Sbjct: 1484 ESQRKRQAEVELASR--VKAEAEAAREKQRALQALEELRLQAEEA----ERRL--RQAEV 1535
Query: 496 EAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERER--ENYMRELRKMLSHKM 553
E A + Q L Q+ + ++++ SF E AQL++ ++ E +RE + + +
Sbjct: 1536 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1595
Query: 554 KVLEELLTEGFKEI--FESLNEEINRLKEQIEAAENEE 589
E E +E+ ++ E RL+ Q E ++
Sbjct: 1596 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1633
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 50.1 bits (118), Expect = 6e-06
Identities = 73/327 (22%), Positives = 139/327 (42%), Gaps = 58/327 (17%)
Query: 318 LAQCENSAAVQRAANHYSQQMAQQVRFPTDTL----QELLDVHAVCEREAIAVF----ME 369
LAQ E + +Q +QQ+A++ + TL Q L++ A ER + V +
Sbjct: 2324 LAQ-EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2382
Query: 370 YSFKDKSQEFQKKLVDTMEK--------KKEDFVLQNEEASAKYCQAELKRLSELLTESI 421
++ +Q F+K+ + EK +++ ++Q E + + +RL E + E
Sbjct: 2383 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE-- 2440
Query: 422 SRGTFFVPGGHNIYLEAKK-KIEQDYTLVPRKGVKADEVLQS-FLQSQVVIEESILQSDK 479
LE +K K++Q+ L+ K + V Q LQ +++S L
Sbjct: 2441 --------------LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2486
Query: 480 ALTAGEKAIAAKQAK------KEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKK 533
+L E+ I ++AK E A+ +Q Q++++QQ ME + + ++ + +++
Sbjct: 2487 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ--MEQERQRLVASMEEARRR 2544
Query: 534 MERERENYMRELRKM--LSHKMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENEEPS 591
E R+ ++ L + + EELL EE RL+EQ++ E + +
Sbjct: 2545 QHEAEEGVRRKQEELQQLEQQRRQQEELLA-----------EENQRLREQLQLLEEQHRA 2593
Query: 592 VFSQILDVAGSIFIA--ALPGAAKLVD 616
+ +V S A LP +D
Sbjct: 2594 ALAHSEEVTASQVAATKTLPNGRDALD 2620
Score = 47.4 bits (111), Expect = 4e-05
Identities = 63/291 (21%), Positives = 128/291 (43%), Gaps = 47/291 (16%)
Query: 311 LENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCEREAIAVFMEY 370
+E A V A+ E + QRA Q +++R + + L V + V +E
Sbjct: 1501 VELASRVKAEAEAAREKQRAL-----QALEELRLQAEEAERRLRQAEVERARQVQVALET 1555
Query: 371 SFKDKSQEFQKKLVDTMEKKKE-DFVLQNEEASAKYCQAELKRLSELLTESISRGTFFVP 429
+ + E Q K EK + + LQ E + + E +R ++ E+
Sbjct: 1556 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA--------- 1606
Query: 430 GGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAIA 489
EA++++E R +KA+E L+ LQ++ V A +K++A
Sbjct: 1607 --ERAREEAERELE-------RWQLKANEALRLRLQAEEV-------------AQQKSLA 1644
Query: 490 AKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERERENYMRELRKML 549
+A+K+ E E+E R++ K ++Q + +E + QE +E++R+ ++ L
Sbjct: 1645 QAEAEKQKEEAERE-ARRRGKAEEQAVRQRELAEQE--------LEKQRQLAEGTAQQRL 1695
Query: 550 SHKMKVLE-ELLTEGFKEIFESLNEEINRLKEQIEAAENEEPSVFSQILDV 599
+ + +++ TE ++ + L EE+ RL+ + AA + + +++ V
Sbjct: 1696 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1746
Score = 41.6 bits (96), Expect = 0.002
Identities = 62/316 (19%), Positives = 132/316 (41%), Gaps = 38/316 (12%)
Query: 296 VETYLDAINSGATPCLENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDV 355
+E L I S A E+ + Q E AA QR + + ++ R + +Q+ L
Sbjct: 1930 LELELGRIRSNA----EDTLRSKEQAELEAARQR---QLAAEEERRRREAEERVQKSLAA 1982
Query: 356 HAVCEREAIAVFMEYSFKDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSE 415
R+ A E E ++L + E++ + +EA+ K QAE K +
Sbjct: 1983 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2042
Query: 416 LLTESISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKAD-------EVLQSFLQSQV 468
+ + E ++ ++Q+ +++ + +A+ E ++ +Q++
Sbjct: 2043 AVQQKEQ--------------ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2088
Query: 469 VIEESILQSDKALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIA 528
+S Q ++A + A QA+ +A ++L ++ ++E + +A++ + ++
Sbjct: 2089 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ--- 2145
Query: 529 QLKKKMERERENYMRELRKMLSHKMKVLEELLT-----EGFKEIFESLNEEINRLKEQIE 583
K+ + E E + + + L K +V +EL T E L+EE+ RLK +
Sbjct: 2146 --KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT 2203
Query: 584 AAENEEPSVFSQILDV 599
A + V ++ V
Sbjct: 2204 EAARQRSQVEEELFSV 2219
Score = 40.0 bits (92), Expect = 0.007
Identities = 32/125 (25%), Positives = 61/125 (48%), Gaps = 8/125 (6%)
Query: 472 ESILQSDKALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQE--RSFQENIAQ 529
E+ L+ + L A A A QA++EA E +Q + + + ++ ++AQ+ RS QE + Q
Sbjct: 1352 EAALEKQRQL-AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ 1410
Query: 530 LKKKMERERENYMRELRKMLSHKMKVLEE-----LLTEGFKEIFESLNEEINRLKEQIEA 584
L++ E E + R+ ++++ EE L E + E+ L+ + E
Sbjct: 1411 LRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEE 1470
Query: 585 AENEE 589
AE ++
Sbjct: 1471 AEAQK 1475
Score = 38.5 bits (88), Expect = 0.019
Identities = 58/285 (20%), Positives = 121/285 (42%), Gaps = 43/285 (15%)
Query: 319 AQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCEREAIAVFMEYSFKDKSQE 378
A+ + AA ++ Q+ A++ + L++ A E E F E + + K+Q
Sbjct: 2113 ARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA--EMEKHKKFAEQTLRQKAQV 2170
Query: 379 FQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLTES------ISRGTFFVPGGH 432
Q+ ++ L+ + EL+RL TE+ + F V
Sbjct: 2171 EQELTTLRLQ-------LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV---- 2219
Query: 433 NIYLEAKKKIEQDYTLVPRKGVKAD-EVLQSFLQSQVVIEESILQSDKALTAGEKAIAAK 491
+ +E K++ R + D + Q FLQ EE+ A A ++AA+
Sbjct: 2220 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQ-----EEAEKMKQVAEEAARLSVAAQ 2274
Query: 492 QAKKEAAEKEQELLRQK-------QKEQQQMMEAQERSFQENIAQLKKKMERERENYMRE 544
+A + E++L +Q+ +++ Q + EA + + Q +K++ +E+ ++E
Sbjct: 2275 EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQE 2334
Query: 545 LRKMLSHKMKVLEELLTEGFKEIFES-------LNEEINRLKEQI 582
++ ++ ++ EE T+GF+ E+ ++ E RLK ++
Sbjct: 2335 DKEQMAQQL--AEE--TQGFQRTLEAERQRQLEMSAEAERLKLRV 2375
Score = 37.7 bits (86), Expect = 0.033
Identities = 68/293 (23%), Positives = 117/293 (39%), Gaps = 52/293 (17%)
Query: 318 LAQCENSAAVQRAANHYSQQMAQQ---VRFPTDTLQ-----ELLDVH-AVCEREAIAVFM 368
LA+ E Q A Q++A + +R +T Q +LL+ A +REA A
Sbjct: 1675 LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA-- 1732
Query: 369 EYSFKDKSQEFQKKLVDTMEK---------KKEDFVLQNEEASAKYCQAELKRLSELLTE 419
K QE + +L + + E+ E S + +AE R EL E
Sbjct: 1733 ----TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1788
Query: 420 SISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDK 479
+ + EAK++ + R+ +A+ VL L + I ++ +
Sbjct: 1789 AARLRA--------LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA-------IGEATR 1833
Query: 480 ALTAGEKAIAAKQAKKEAAEK--EQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERE 537
T E A+ K+A+ E + E E ++++ E+Q + +E +AQL+K + E
Sbjct: 1834 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD--IEERLAQLRKASDSE 1891
Query: 538 RENYMRELRKMLSHKMKVLEELLTEGFKEIFE-------SLNEEINRLKEQIE 583
E + L + +V EE+L K FE L E+ R++ E
Sbjct: 1892 LERQKGLVEDTLRQRRQVEEEIL--ALKASFEKAAAGKAELELELGRIRSNAE 1942
Score = 36.2 bits (82), Expect = 0.095
Identities = 38/158 (24%), Positives = 77/158 (48%), Gaps = 13/158 (8%)
Query: 437 EAKKKIEQDYTLVPRKGVKAD-EVLQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAKK 495
E+++K + + L R VKA+ E + ++ +EE LQ+++A E+ + +QA+
Sbjct: 1492 ESQRKRQAEVELASR--VKAEAEAAREKQRALQALEELRLQAEEA----ERRL--RQAEV 1543
Query: 496 EAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERER--ENYMRELRKMLSHKM 553
E A + Q L Q+ + ++++ SF E AQL++ ++ E +RE + + +
Sbjct: 1544 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1603
Query: 554 KVLEELLTEGFKEI--FESLNEEINRLKEQIEAAENEE 589
E E +E+ ++ E RL+ Q E ++
Sbjct: 1604 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1641
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.131 0.369
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,773,572
Number of Sequences: 37866
Number of extensions: 1006071
Number of successful extensions: 13563
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 291
Number of HSP's successfully gapped in prelim test: 850
Number of HSP's that attempted gapping in prelim test: 6825
Number of HSP's gapped (non-prelim): 4243
length of query: 638
length of database: 18,247,518
effective HSP length: 109
effective length of query: 529
effective length of database: 14,120,124
effective search space: 7469545596
effective search space used: 7469545596
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.