Guide to the Human Genome
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Search of human proteins with 148233522

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|148233522 coiled-coil domain containing 102B [Homo sapiens]
         (513 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|147905592 coiled-coil domain containing 102B [Homo sapiens]       1024   0.0  
gi|148233522 coiled-coil domain containing 102B [Homo sapiens]       1024   0.0  
gi|226495417 coiled-coil domain containing 102A [Homo sapiens]        370   e-102
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]    88   2e-17
gi|31982906 cingulin-like 1 [Homo sapiens]                             87   5e-17
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [...    81   3e-15
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s...    80   6e-15
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]     79   8e-15
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo...    79   8e-15
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo...    79   8e-15
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ...    79   1e-14
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo...    77   3e-14
gi|156104908 myosin heavy chain 6 [Homo sapiens]                       77   4e-14
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo...    76   6e-14
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...    74   2e-13
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...    74   2e-13
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...    74   2e-13
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...    74   2e-13
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ...    74   3e-13
gi|46049114 M-phase phosphoprotein 1 [Homo sapiens]                    74   3e-13
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H...    74   4e-13
gi|4502443 dystonin isoform 1e precursor [Homo sapiens]                74   4e-13
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]                   73   5e-13
gi|71061468 centromere protein E [Homo sapiens]                        72   1e-12
gi|55770834 centromere protein F [Homo sapiens]                        72   2e-12
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa...    71   3e-12
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s...    71   3e-12
gi|148762940 DVL-binding protein DAPLE [Homo sapiens]                  70   6e-12
gi|16262452 cingulin [Homo sapiens]                                    68   2e-11
gi|21735548 centrosomal protein 2 [Homo sapiens]                       68   2e-11

>gi|147905592 coiled-coil domain containing 102B [Homo sapiens]
          Length = 513

 Score = 1024 bits (2648), Expect = 0.0
 Identities = 513/513 (100%), Positives = 513/513 (100%)

Query: 1   MNLDSIHRLIEETQIFQMQQSSIKSRGDMVAPASPPRDTCNTCFPLHGLQSHAAHNFCAH 60
           MNLDSIHRLIEETQIFQMQQSSIKSRGDMVAPASPPRDTCNTCFPLHGLQSHAAHNFCAH
Sbjct: 1   MNLDSIHRLIEETQIFQMQQSSIKSRGDMVAPASPPRDTCNTCFPLHGLQSHAAHNFCAH 60

Query: 61  SYNTNKWDICEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEG 120
           SYNTNKWDICEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEG
Sbjct: 61  SYNTNKWDICEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEG 120

Query: 121 RQLRIKLEMAMKELSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQM 180
           RQLRIKLEMAMKELSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQM
Sbjct: 121 RQLRIKLEMAMKELSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQM 180

Query: 181 HESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTG 240
           HESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTG
Sbjct: 181 HESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTG 240

Query: 241 LRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYE 300
           LRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYE
Sbjct: 241 LRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYE 300

Query: 301 ELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENT 360
           ELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENT
Sbjct: 301 ELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENT 360

Query: 361 SEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKN 420
           SEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKN
Sbjct: 361 SEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKN 420

Query: 421 QELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELD 480
           QELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELD
Sbjct: 421 QELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELD 480

Query: 481 DSLNQIRKLQRSLDEEKERNENLETELRHLQNW 513
           DSLNQIRKLQRSLDEEKERNENLETELRHLQNW
Sbjct: 481 DSLNQIRKLQRSLDEEKERNENLETELRHLQNW 513


>gi|148233522 coiled-coil domain containing 102B [Homo sapiens]
          Length = 513

 Score = 1024 bits (2648), Expect = 0.0
 Identities = 513/513 (100%), Positives = 513/513 (100%)

Query: 1   MNLDSIHRLIEETQIFQMQQSSIKSRGDMVAPASPPRDTCNTCFPLHGLQSHAAHNFCAH 60
           MNLDSIHRLIEETQIFQMQQSSIKSRGDMVAPASPPRDTCNTCFPLHGLQSHAAHNFCAH
Sbjct: 1   MNLDSIHRLIEETQIFQMQQSSIKSRGDMVAPASPPRDTCNTCFPLHGLQSHAAHNFCAH 60

Query: 61  SYNTNKWDICEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEG 120
           SYNTNKWDICEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEG
Sbjct: 61  SYNTNKWDICEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEG 120

Query: 121 RQLRIKLEMAMKELSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQM 180
           RQLRIKLEMAMKELSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQM
Sbjct: 121 RQLRIKLEMAMKELSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQM 180

Query: 181 HESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTG 240
           HESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTG
Sbjct: 181 HESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTG 240

Query: 241 LRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYE 300
           LRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYE
Sbjct: 241 LRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYE 300

Query: 301 ELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENT 360
           ELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENT
Sbjct: 301 ELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENT 360

Query: 361 SEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKN 420
           SEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKN
Sbjct: 361 SEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKN 420

Query: 421 QELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELD 480
           QELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELD
Sbjct: 421 QELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELD 480

Query: 481 DSLNQIRKLQRSLDEEKERNENLETELRHLQNW 513
           DSLNQIRKLQRSLDEEKERNENLETELRHLQNW
Sbjct: 481 DSLNQIRKLQRSLDEEKERNENLETELRHLQNW 513


>gi|226495417 coiled-coil domain containing 102A [Homo sapiens]
          Length = 550

 Score =  370 bits (950), Expect = e-102
 Identities = 212/449 (47%), Positives = 297/449 (66%), Gaps = 13/449 (2%)

Query: 67  WDICEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIK 126
           W+  EELRLRELEE +ARAAQMEKTMR WSDCTANWREKWSKVRAERN AREE RQLR +
Sbjct: 69  WESREELRLRELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQLRQR 128

Query: 127 LEMAMKELSTLKK-KQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIR 185
           L+   KEL+  ++ +Q    + EA    + +     G  +++ +  +         E+ R
Sbjct: 129 LDALTKELAGARRERQEAQGECEARGRELARLRGARGVADQTRDGPEP--------EAER 180

Query: 186 EYLVKRQFSTKEDTNNKEQGVVIDSLK-LSEEMKPNLDGVDLFNNGGSGNGETKTGLRLK 244
           E +  R   ++    ++E  +V   LK + EE +   +   L   G  G+   +   RL 
Sbjct: 181 EPV--RDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLP 238

Query: 245 -AINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELK 303
                  E E ++++AL++ LDE QK+L KERE + AL + IE+LE  LS WK KYEEL 
Sbjct: 239 WEDTAATEEEASKLTALRLRLDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELS 298

Query: 304 ESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEW 363
           ++K + +K+  IL   H DE+  +S ++++E  +++S DR + ELR E+ERLQAEN +EW
Sbjct: 299 KTKQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAAEW 358

Query: 364 DKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQEL 423
            +RE LE EK GLEREN++L+ QV ++EE L ++ R +A++   D + SQ  L EKN+EL
Sbjct: 359 GRRERLETEKLGLERENKKLRAQVGDLEEALARRRRQTASALDCDLRASQAALFEKNKEL 418

Query: 424 LNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSL 483
            +L+H + KL +Q+Q  +AEL HAN RV+Q+EAEVKKLRLRVEELK+ L Q EDELD++ 
Sbjct: 419 ADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDELDEAH 478

Query: 484 NQIRKLQRSLDEEKERNENLETELRHLQN 512
           NQ RKLQRSLDE+ E++ENL+ +L HLQ+
Sbjct: 479 NQARKLQRSLDEQTEQSENLQVQLEHLQS 507



 Score = 38.1 bits (87), Expect = 0.019
 Identities = 66/325 (20%), Positives = 128/325 (39%), Gaps = 39/325 (12%)

Query: 70  CEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEM 129
           C E R       +  + + E++   W D TA   E+ SK+ A           LR++L+ 
Sbjct: 214 CWEARSLGAGGPRGSSGRQERSRLPWED-TAATEEEASKLTA-----------LRLRLDE 261

Query: 130 AMKELSTLKK-KQSLPPQKEALEANVTQ-DLKLPGFVEESCEHTDQFQLSSQMHESIREY 187
           + K L   ++ K +L    E LE  ++Q  +K     +   E   Q  +  + H+     
Sbjct: 262 SQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELSKTKQEMLKQLSILKEAHQD---- 317

Query: 188 LVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAIN 247
               +     +    E G      +   E++  ++ +   N    G  E     RL+   
Sbjct: 318 ----ELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAAEWGRRE-----RLETEK 368

Query: 248 LPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELKESKP 307
           L LE E  ++ A    L+E   +  + R+  +AL+ ++   ++AL     +  +LK    
Sbjct: 369 LGLERENKKLRAQVGDLEE--ALARRRRQTASALDCDLRASQAALFEKNKELADLKHVHG 426

Query: 308 KNVKEFDILLG----------QHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQA 357
           K  K+F   +           QH  E+++L   ++E  K     +  + E   +  +LQ 
Sbjct: 427 KLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDELDEAHNQARKLQR 486

Query: 358 ENTSEWDKREILEREKQGLERENRR 382
               + ++ E L+ + + L+   RR
Sbjct: 487 SLDEQTEQSENLQVQLEHLQSRLRR 511


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 102/458 (22%), Positives = 204/458 (44%), Gaps = 52/458 (11%)

Query: 100  ANWREKWSKVRA------ERNSAREE----GRQLRIKLEMAMKELSTLKKK-QSLPPQKE 148
            A  REK +K  +      E   A+EE     +QLR  +E  M     + K    L   K 
Sbjct: 1476 AEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKR 1535

Query: 149  ALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIREYLVKRQFSTKEDTNNKEQGVVI 208
            ALE  V +       +E+  + T+  +L  +++    +   +R   T+++ N +++ ++I
Sbjct: 1536 ALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLI 1595

Query: 209  DSLK-----LSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLENEVTEISALQVH 263
              ++     L +E K     V           + +   +++A N   +  + ++  LQ  
Sbjct: 1596 KQVRELEAELEDERKQRALAVASKKKMEIDLKDLEA--QIEAANKARDEVIKQLRKLQAQ 1653

Query: 264  LDEFQKILWKEREMRTAL-------EKEIERLESALSLWKWKYEELKESKPKNVKEFDIL 316
            + ++Q+ L + R  R  +       EK+++ LE+ +   + +    + ++    +E D L
Sbjct: 1654 MKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDEL 1713

Query: 317  LGQHN----------DEMQELSGNI--------KEESKSQNSKDRVICELRAELERLQAE 358
              +            DE + L   I        +E+S  +   DR   +   +++ L AE
Sbjct: 1714 ADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDR-FRKTTLQVDTLNAE 1772

Query: 359  NTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQE 418
              +E    +  +  +Q LER+N+ LK +++E+E  +  K++  A   + + K+ Q  L+E
Sbjct: 1773 LAAERSAAQKSDNARQQLERQNKELKAKLQELEGAV--KSKFKATISALEAKIGQ--LEE 1828

Query: 419  KNQELLNLQHAYYKLNRQYQANIAEL----THANNRVDQNEAEVKKLRLRVEELKQGLNQ 474
            + ++    + A  KL R+ +  + E+           DQ + +++K   R+++LK+ L +
Sbjct: 1829 QLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEE 1888

Query: 475  KEDELDDSLNQIRKLQRSLDEEKERNENLETELRHLQN 512
             E+E   +    RKLQR LD+  E NE L  E+  L+N
Sbjct: 1889 AEEEATRANASRRKLQRELDDATEANEGLSREVSTLKN 1926



 Score = 65.9 bits (159), Expect = 9e-11
 Identities = 119/531 (22%), Positives = 221/531 (41%), Gaps = 96/531 (18%)

Query: 65   NKWDICEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLR 124
            NK   CE   ++ L++VKA +    K +       A  +E  +KV +E +  R E  +  
Sbjct: 1233 NKELACE---VKVLQQVKAESEHKRKKL------DAQVQELHAKV-SEGDRLRVELAEKA 1282

Query: 125  IKLEMAMKELSTL------------KKKQSLPPQ----KEALEANVTQDLKLPGFVEESC 168
             KL+  +  +STL            K   SL  Q    +E L+    Q L L   + +  
Sbjct: 1283 SKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLE 1342

Query: 169  EHTDQFQLSSQMHESIREYLVKRQFSTKE---DTNNKEQGVVIDSLKLSEEMKPNLDGVD 225
            E  +  Q   +  E  R+ L K+  + +    DT  K    +     L E  K  L   +
Sbjct: 1343 EEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAE 1402

Query: 226  LFNNGGSGNG-------ETKTGLR--LKAINLPLENEVTEISALQVHLDEFQKILWKERE 276
              +              +TK  L+  L  + + L+++    S L+    +F ++L +E+ 
Sbjct: 1403 ALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKS 1462

Query: 277  MRTALEKEIERLES--------ALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQ--- 325
            +     +E +R E+        ALSL +   EE  E+K +  ++   L     D M    
Sbjct: 1463 ISARYAEERDRAEAEAREKETKALSLAR-ALEEALEAKEEFERQNKQLRADMEDLMSSKD 1521

Query: 326  ELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWD----------------KREIL 369
            ++  N+ E  KS+ + ++ + E+R +LE L+ E  +  D                +R++ 
Sbjct: 1522 DVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQ 1581

Query: 370  EREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHA 429
             R++Q  E++   +K QV+E+E  L+ + +  A + +   KM +IDL++   ++     A
Sbjct: 1582 TRDEQNEEKKRLLIK-QVRELEAELEDERKQRALAVASKKKM-EIDLKDLEAQIEAANKA 1639

Query: 430  YYKLNRQ----------YQANIAELTHANNRV----DQNEAEVKKLRLRVEELKQGL--- 472
              ++ +Q          YQ  + E   + + +     ++E ++K L   + +L++ L   
Sbjct: 1640 RDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASS 1699

Query: 473  -------NQKEDELDDSLNQIRKLQRSLDEEKERNE----NLETELRHLQN 512
                    Q+ DEL D +      + +L +EK R E     LE EL   Q+
Sbjct: 1700 ERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQS 1750



 Score = 57.0 bits (136), Expect = 4e-08
 Identities = 100/462 (21%), Positives = 192/462 (41%), Gaps = 52/462 (11%)

Query: 70   CEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSARE--EGRQLRIKL 127
            C      E E+ K  A    K     SD     +++  K R E   A+   +G    ++ 
Sbjct: 1011 CSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKE-EKTRQELEKAKRKLDGETTDLQD 1069

Query: 128  EMAMKELSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIREY 187
            ++A  +    + K  L  ++E L+  + +        +E+    +  ++  ++   I E 
Sbjct: 1070 QIAELQAQIDELKLQLAKKEEELQGALARG------DDETLHKNNALKVVRELQAQIAE- 1122

Query: 188  LVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAIN 247
             ++  F +++ + NK +    D  +  E +K  L+   L          TK    +  + 
Sbjct: 1123 -LQEDFESEKASRNKAEKQKRDLSEELEALKTELEDT-LDTTAAQQELRTKREQEVAELK 1180

Query: 248  LPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELKESKP 307
              LE E     A         +I    +   TALE+  E+LE A   +K   E+ K+   
Sbjct: 1181 KALEEETKNHEA---------QIQDMRQRHATALEELSEQLEQA-KRFKANLEKNKQGLE 1230

Query: 308  KNVKEFDI-------LLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENT 360
             + KE          +  +   + ++L   ++E     +  DR+  EL  +  +LQ E  
Sbjct: 1231 TDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELD 1290

Query: 361  SEWDKREILEREKQGLE--RENRRLKIQVKEMEELLDKKNR--LSANSQSPDFKMSQIDL 416
            +     E  E EK+G++  ++   L+ Q+++ +ELL ++ R  L+ +S+    +  +  L
Sbjct: 1291 NVSTLLE--EAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSL 1348

Query: 417  QEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQN-------EAEVKKLRLRVEELK 469
            QE+ +E    + A   L +Q  A  ++L     +VD +       E   KKL    E L 
Sbjct: 1349 QEQQEE---EEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALS 1405

Query: 470  QGLNQKE---DELDDSLNQIRK----LQRSLDEEKERNENLE 504
            Q L +K    D+L+ + N++++    L   LD +++   NLE
Sbjct: 1406 QRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLE 1447



 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 61/269 (22%), Positives = 116/269 (43%), Gaps = 38/269 (14%)

Query: 241  LRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYE 300
            L++K     +E E+ E+      L E + IL ++ +  T L  E E + + L+  K + E
Sbjct: 862  LKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELE 921

Query: 301  ELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQ-NSKDRVICELRAELERLQAEN 359
            E+       V+E         +E  ++  N K++ ++     +  + E     ++LQ E 
Sbjct: 922  EILHDLESRVEE--------EEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEK 973

Query: 360  TSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEK 419
             +   K + +E E   LE +N +   + K ME+ + +      +SQ          L E+
Sbjct: 974  VTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAE-----CSSQ----------LAEE 1018

Query: 420  NQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDEL 479
             ++  NL     K+  + +  I++L          E  +KK     +EL++   + + E 
Sbjct: 1019 EEKAKNLA----KIRNKQEVMISDL----------EERLKKEEKTRQELEKAKRKLDGET 1064

Query: 480  DDSLNQIRKLQRSLDEEKERNENLETELR 508
             D  +QI +LQ  +DE K +    E EL+
Sbjct: 1065 TDLQDQIAELQAQIDELKLQLAKKEEELQ 1093



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 31/104 (29%), Positives = 57/104 (54%), Gaps = 14/104 (13%)

Query: 415 DLQEKNQELLNLQHAYYK-------LNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEE 467
           +LQ K++ELL ++    K       + R++Q  + E    N   +Q +AE + L    EE
Sbjct: 853 ELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEE---KNILAEQLQAETE-LFAEAEE 908

Query: 468 LKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRHLQ 511
           ++  L  K+ EL++ L+    L+  ++EE+ERN+ L+ E + +Q
Sbjct: 909 MRARLAAKKQELEEILHD---LESRVEEEEERNQILQNEKKKMQ 949



 Score = 39.7 bits (91), Expect = 0.007
 Identities = 69/344 (20%), Positives = 137/344 (39%), Gaps = 79/344 (22%)

Query: 76   RELEEVKA-------RAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLE 128
            RELEE +A       ++ + EK ++         +E+ +     R  A +E      + E
Sbjct: 1659 RELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQE------RDE 1712

Query: 129  MAMKELSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEH--------TDQFQLSSQM 180
            +A +  ++   K +L  +K  LEA + Q       +EE  E          D+F+ ++  
Sbjct: 1713 LADEITNSASGKSALLDEKRRLEARIAQ-------LEEELEEEQSNMELLNDRFRKTTLQ 1765

Query: 181  HESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTG 240
             +++   L   + + ++  N ++Q       + ++E+K  L  ++         G  K+ 
Sbjct: 1766 VDTLNAELAAERSAAQKSDNARQQ-----LERQNKELKAKLQELE---------GAVKSK 1811

Query: 241  LRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYE 300
             +              ISAL+  + + ++ L +E + R A  K + R E           
Sbjct: 1812 FK------------ATISALEAKIGQLEEQLEQEAKERAAANKLVRRTE----------- 1848

Query: 301  ELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENT 360
                   K +KE   +  Q  DE +  +   KE+ +  N++ +   +L+ +LE  + E T
Sbjct: 1849 -------KKLKE---IFMQVEDERRH-ADQYKEQMEKANARMK---QLKRQLEEAEEEAT 1894

Query: 361  SEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANS 404
                 R  L+RE       N  L  +V  ++  L +   +S +S
Sbjct: 1895 RANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPISFSS 1938



 Score = 33.9 bits (76), Expect = 0.36
 Identities = 38/176 (21%), Positives = 83/176 (47%), Gaps = 25/176 (14%)

Query: 340 SKDRVICELRAELERLQAENTSEW---DKREILEREKQGLERENRRLKIQVKEMEELLDK 396
           +K + + ++  + E LQA++       +K+  +E E + +ER++++L  +   + E L  
Sbjct: 839 TKVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQA 898

Query: 397 KNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEA 456
           +  L A ++       +  L  K QEL  + H         ++ + E     N++ QNE 
Sbjct: 899 ETELFAEAEE-----MRARLAAKKQELEEILH-------DLESRVEE-EEERNQILQNEK 945

Query: 457 EVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRHLQN 512
             KK++  +++L       E++LD+     +KLQ      + + + +E E+  L++
Sbjct: 946 --KKMQAHIQDL-------EEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLED 992


>gi|31982906 cingulin-like 1 [Homo sapiens]
          Length = 1302

 Score = 86.7 bits (213), Expect = 5e-17
 Identities = 104/448 (23%), Positives = 215/448 (47%), Gaps = 47/448 (10%)

Query: 79   EEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAMKE-LSTL 137
            EE++ R AQ+++ +       A  +E   K   E        RQL   L  A KE    +
Sbjct: 839  EELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEI-------RQLEEALVHARKEEKEAV 891

Query: 138  KKKQSLPPQKEALEANVTQDLK----LPGFVEESCEHTDQFQLSSQMHESIREYLVKRQF 193
              +++L  + EA + N++Q  +    L   ++E  E  +Q +      E+ R +L K   
Sbjct: 892  SARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGK--- 948

Query: 194  STKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLENE 253
             T E    +   +V  S   + E++  LD     N       E +  L+ K     LE E
Sbjct: 949  -TIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELA--EMQRQLKEKT----LEAE 1001

Query: 254  VTEISALQVHLDEFQKILWKEREMRTALEKEIER---LESALSLWKWKYE---ELKESKP 307
             + ++A+++  DE + +  + R+ + A ++ + +   LE  L   +++ E    LK+ + 
Sbjct: 1002 KSRLTAMKMQ-DEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRS 1060

Query: 308  KNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWDKRE 367
            + VK+ +       D++ +L   ++EE  + +     I   R ++E+L+ E   E   R+
Sbjct: 1061 RLVKQME-------DKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQ 1113

Query: 368  ILEREKQGLERENRRLKIQVKEME-ELLDKKNRLSANSQSPDFKMSQID--LQEKNQELL 424
             LE +K  LER+N+ LK ++  +E      K  L    ++   ++++++  L+ + ++  
Sbjct: 1114 DLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEA---RIAELEDRLESEERDRA 1170

Query: 425  NLQHAYYKLNRQYQANIAELTHAN-NRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSL 483
            NLQ +  +L R+ +  + ++   + +  DQ +    +L LR++ +K+ + + E+E+D   
Sbjct: 1171 NLQLSNRRLERKVKELVMQVDDEHLSLTDQKD----QLSLRLKAMKRQVEEAEEEIDRLE 1226

Query: 484  NQIRKLQRSLDEEKERNENLETELRHLQ 511
            +  +KLQR L+E+ + NE+L+ +L  ++
Sbjct: 1227 SSKKKLQRELEEQMDMNEHLQGQLNSMK 1254



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 90/442 (20%), Positives = 171/442 (38%), Gaps = 87/442 (19%)

Query: 126 KLEMAMKELSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIR 185
           K+ +  +++ TLK + +   Q      N T ++K            D  +  S++   + 
Sbjct: 577 KVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVK------------DLLEQKSKLTIEVA 624

Query: 186 EYLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGG------------SG 233
           E   + Q   K   N KE+          E M+ NL+ +   +N                
Sbjct: 625 ELQRQLQLEVKNQQNIKEE---------RERMRANLEELRSQHNEKVEENSTLQQRLEES 675

Query: 234 NGETKTGLR-LKAINLPLENEVTEISALQVHLDEFQKIL-----WKEREMRTALEKEIER 287
            GE +  L  L  + +  E   TEI  LQ  L E    L      ++RE    +E+ ++ 
Sbjct: 676 EGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQA 735

Query: 288 LESALSLWKWKYEE-----------------LKESKPKNVKEFDILLGQHNDEMQELSGN 330
            +    L   K E+                 LKE    + +E D L  Q++ E+Q L  +
Sbjct: 736 KQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRES 795

Query: 331 IKEESKS---------QNSKDRVICELRAELERLQAENTSEWDKREILEREKQGLERENR 381
           ++E +K+          + +D+   E+R +L  LQ EN     + E LER    L+R+  
Sbjct: 796 VEEATKNVEVLASRSNTSEQDQAGTEMRVKL--LQEENEKLQGRSEELERRVAQLQRQIE 853

Query: 382 RLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANI 441
            LK    + +E L K        +    + + +  +++ +E ++ + A        Q N+
Sbjct: 854 DLKGDEAKAKETLKK-----YEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNL 908

Query: 442 AELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRK------------- 488
           ++ T    ++ +   E  + + ++  LK  +  +   L  ++ +++K             
Sbjct: 909 SQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTST 968

Query: 489 --LQRSLDEEKERNENLETELR 508
             LQ  LDE KE+N     E++
Sbjct: 969 LELQNQLDEYKEKNRRELAEMQ 990



 Score = 38.9 bits (89), Expect = 0.011
 Identities = 47/200 (23%), Positives = 87/200 (43%), Gaps = 33/200 (16%)

Query: 314 DILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWDKREILEREK 373
           D+L GQ     QEL+    EE+  Q   + +        +  + +    ++K + L+   
Sbjct: 538 DLLKGQ-----QELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRA 592

Query: 374 QGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYYKL 433
            G  + N +      E+++LL++K++L+           Q+ L+ KNQ+ +  +      
Sbjct: 593 AGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAE---LQRQLQLEVKNQQNIKEER----- 644

Query: 434 NRQYQANIAEL-THANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRS 492
             + +AN+ EL +  N +V++N             L+Q L + E EL       RK    
Sbjct: 645 -ERMRANLEELRSQHNEKVEENST-----------LQQRLEESEGEL-------RKNLEE 685

Query: 493 LDEEKERNENLETELRHLQN 512
           L + K   E  +TE+R LQ+
Sbjct: 686 LFQVKMEREQHQTEIRDLQD 705


>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
            sapiens]
          Length = 1937

 Score = 80.9 bits (198), Expect = 3e-15
 Identities = 109/506 (21%), Positives = 222/506 (43%), Gaps = 75/506 (14%)

Query: 71   EELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKL--- 127
            E+L L ++E   A  A ++K  R +    + W++K+ + +AE  ++++E R L  +L   
Sbjct: 1429 EDLML-DVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKV 1487

Query: 128  ----EMAMKELSTLKKKQSLPPQK------------------EALEANVTQD-LKLPGFV 164
                E ++ +L TL+++     Q+                  E ++  V Q+  ++   +
Sbjct: 1488 KNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAAL 1547

Query: 165  EE---SCEHTD------QFQLSSQMHESIREYLVK------------RQFSTKEDTNNKE 203
            EE   S EH +      Q +L+    E  R+   K            R   T + T + E
Sbjct: 1548 EEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAE 1607

Query: 204  QGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLP-LENEVTEISALQV 262
                 D+L++ ++M+ +L+ +++  N  +         RL A +L    N    +   Q+
Sbjct: 1608 IRSRNDALRVKKKMEGDLNEMEIQLNHAN---------RLAAESLRNYRNTQGILKETQL 1658

Query: 263  HLDEFQKILWKEREMRTALEKEIERLESALS-LWKW-----KYEELKESKPKNVKEFDIL 316
            HLD+  +     +E    +E+    L++ +  LW       +  ++ E +  +  E   L
Sbjct: 1659 HLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQL 1718

Query: 317  LGQHNDEMQELSGNIKEE-SKSQNSKDRVICELRAELERLQAENTSEWDKREILEREKQG 375
            L   N  +      ++ + S+ Q+  + VI E R   E+ +   T      E L++E+  
Sbjct: 1719 LHTQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDT 1778

Query: 376  ---LERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAY-- 430
               LER  + L+  VK+++  LD+  +L+        +  +  ++E   E+ N Q     
Sbjct: 1779 SAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAE 1838

Query: 431  -YKLNRQYQANIAELTHANNRVDQNEAE----VKKLRLRVEELKQGLNQKEDELDDSLNQ 485
              K  R+++  + ELT+      +N       V KL+ +V+  K+   + E++ + +L++
Sbjct: 1839 AVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSK 1898

Query: 486  IRKLQRSLDEEKERNENLETELRHLQ 511
             RKLQ  L+E +ER +  E+++  L+
Sbjct: 1899 FRKLQHELEEAEERADIAESQVNKLR 1924



 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 91/451 (20%), Positives = 198/451 (43%), Gaps = 57/451 (12%)

Query: 84   RAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAMKELSTLK----- 138
            ++A+ EK M       A  +E++ K + E   +  + ++L  K+   +KE + L+     
Sbjct: 844  KSAETEKEM-------ATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQS 896

Query: 139  KKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIREYLVKRQFSTKED 198
            +  SL   +E  E  +   ++L   ++E  E  ++ +  +    + +  L       K+D
Sbjct: 897  EADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKD 956

Query: 199  TNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGET--KTGLRLKAINLPLENEVTE 256
             ++ E    +   K+ +E     + V       +G  ET  K     KA+    +  + +
Sbjct: 957  IDDLE----LTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDD 1012

Query: 257  ISA--------------LQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEEL 302
            + A              L+  +D+ +  L +E+++R  LE+   +LE  L L +    ++
Sbjct: 1013 LQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDM 1072

Query: 303  KESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSE 362
            +  K    ++ D  L +   E+  L   I++E   +    + I EL+A +E L  E  +E
Sbjct: 1073 ENDK----QQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAE 1128

Query: 363  WDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQ- 421
               R   E+++  L RE       ++E+ E L++    ++         +Q++L +K + 
Sbjct: 1129 RASRAKAEKQRSDLSRE-------LEEISERLEEAGGATS---------AQVELNKKREA 1172

Query: 422  ELLNLQHAYYKLNRQYQANIAELT--HANNRVDQNEA--EVKKLRLRVEELKQGLNQKED 477
            E   L+    +   Q++A +A L   HA++  +  E    +++++ ++E+ K  L  + D
Sbjct: 1173 EFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETD 1232

Query: 478  ELDDSLNQIRKLQRSLDEEKERNENLETELR 508
            +L  +   I K + +L++     E+  +EL+
Sbjct: 1233 DLSSNAEAISKAKGNLEKMCRSLEDQVSELK 1263



 Score = 59.3 bits (142), Expect = 8e-09
 Identities = 96/464 (20%), Positives = 188/464 (40%), Gaps = 71/464 (15%)

Query: 68   DICEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWS-------KVRAERNSAREEG 120
            D C EL+ +++++++   A++EK      +   N  E+ +       K+  E+ + +E  
Sbjct: 948  DECSELK-KDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETH 1006

Query: 121  RQLRIKLEMAMKELSTLKK-KQSLPPQKEALEANVTQDLKL-----------PGFVEESC 168
            +Q    L+    +++ L K K  L  Q + LE ++ Q+ KL            G ++ + 
Sbjct: 1007 QQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQ 1066

Query: 169  EHT-----DQFQLSSQMHESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDG 223
            E T     D+ QL  ++ +  +E+ +    S  ED    EQ V I   K  +E++  ++ 
Sbjct: 1067 ESTMDMENDKQQLDEKLEK--KEFEISNLISKIED----EQAVEIQLQKKIKELQARIEE 1120

Query: 224  VDLFNNGGSGNGETKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEK 283
            +     G     E  +  + +     L  E+ EIS     L+E       + E+    E 
Sbjct: 1121 L-----GEEIEAERASRAKAEKQRSDLSRELEEISE---RLEEAGGATSAQVELNKKREA 1172

Query: 284  EIERLESALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDR 343
            E ++L            +L+E+  ++      L  +H D M EL   I       ++  R
Sbjct: 1173 EFQKLR----------RDLEEATLQHEAMVAALRKKHADSMAELGEQI-------DNLQR 1215

Query: 344  VICELRAELERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSAN 403
            V  +L  E   L+ E        E + + K  LE+  R L+ QV E++   +++ RL   
Sbjct: 1216 VKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRL--- 1272

Query: 404  SQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRL 463
                        + +   +   LQ    + +RQ     A ++  +     +  ++++L+ 
Sbjct: 1273 ------------INDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKH 1320

Query: 464  RVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETEL 507
            ++EE  +  N     L  S +    L+   +EE+E    L+  L
Sbjct: 1321 QLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRAL 1364



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 106/478 (22%), Positives = 205/478 (42%), Gaps = 74/478 (15%)

Query: 72   ELRLRELEE-VKARAAQMEKTMRWWSDCTANWREKWSKVRAE-RNSAREEGRQLRIKLEM 129
            E   R LE+ V     + E+  R  +D TA         RA  +  A E  RQL  K + 
Sbjct: 1249 EKMCRSLEDQVSELKTKEEEQQRLINDLTAQ--------RARLQTEAGEYSRQLDEK-DA 1299

Query: 130  AMKELSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHT--------DQFQLSSQMH 181
             + +LS  + KQ+   Q E L+  + ++ K    +  + + +        +Q++   +  
Sbjct: 1300 LVSQLS--RSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGK 1357

Query: 182  ESIREYLVKR-----QFSTKEDTNNKEQGVVIDSLK--LSEEMKPNLDGVDLFNNGGSGN 234
              ++  L K      Q+ TK +T+  ++   ++  K  L++ ++   + V+  N   +  
Sbjct: 1358 AELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASL 1417

Query: 235  GETKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSL 294
             +TK  L+ +  +L L+ E +  +                     AL+K+    +  LS 
Sbjct: 1418 EKTKQRLQNEVEDLMLDVERSNAAC-------------------AALDKKQRNFDKVLSE 1458

Query: 295  WKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQ-NSKDRVICELRAELE 353
            WK KYEE +     + KE   L    + E+ ++  N+ EES  Q  +  R    L+ E+ 
Sbjct: 1459 WKQKYEETQAELEASQKESRSL----STELFKVK-NVYEESLDQLETLRRENKNLQQEIS 1513

Query: 354  RLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLD-KKNRLSANSQSPDFKMS 412
             L  +      +   LE+ K+ +E+E   ++  ++E E  L+ ++ ++       +   S
Sbjct: 1514 DLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKS 1573

Query: 413  QID--LQEKNQELLNLQHAYYKLNRQYQANI-AELTHANNRV--------DQNEAEVK-- 459
            ++D  + EK++E+  L+  + ++    Q+ + AE+   N+ +        D NE E++  
Sbjct: 1574 EVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLN 1633

Query: 460  -KLRLRVEELK-----QG-LNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRHL 510
               RL  E L+     QG L + +  LDD+L     L+  L   + R   L+ E+  L
Sbjct: 1634 HANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAEIEEL 1691


>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
            sapiens]
          Length = 1935

 Score = 79.7 bits (195), Expect = 6e-15
 Identities = 104/495 (21%), Positives = 212/495 (42%), Gaps = 64/495 (12%)

Query: 77   ELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKL-------EM 129
            ++E   A AA ++K  R +    A W++K+ + ++E  S+++E R L  +L       E 
Sbjct: 1431 DVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEE 1490

Query: 130  AMKELSTLKKKQS----------------------LPPQKEALEANVTQDLKLPGFVEES 167
            +++ L T K++                        L   ++ LEA   +        E S
Sbjct: 1491 SLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEAS 1550

Query: 168  CEHTDQFQLSSQMHESIREYLVKRQFSTKEDTNNKEQGV---VIDSLKLSEEMKPNLDGV 224
             EH +   L +Q+  +  +  ++R+ + K++   + +     V+DSL+ S + +      
Sbjct: 1551 LEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNE 1610

Query: 225  DLFNNGGSGNGETKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKE 284
             L           +  ++L   N        ++ +LQ  L + Q  L         L++ 
Sbjct: 1611 ALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKEN 1670

Query: 285  IERLESALSLWKWKYEELK---ESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSK 341
            I  +E   +L + + EEL+   E   ++ K  +  L + ++ +Q L          +   
Sbjct: 1671 IAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKM 1730

Query: 342  DRVICELRAELERLQAE--NTSEWDKREI---------LEREKQG---LERENRRLKIQV 387
            D  + +L+ E+E    E  N  E  K+ I         L++E+     LER  + ++  +
Sbjct: 1731 DADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTI 1790

Query: 388  KEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLN-------RQYQAN 440
            K+++  LD+  +++        +     L+ + +EL N   A  K N       R+ +  
Sbjct: 1791 KDLQHRLDEAEQIALKGGKKQLQK----LEARVRELENELEAEQKRNAESVKGMRKSERR 1846

Query: 441  IAELTHANNRVDQN----EAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEE 496
            I ELT+      +N    +  V KL+L+V+  K+   + E++ + +L++ RK+Q  LDE 
Sbjct: 1847 IKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEA 1906

Query: 497  KERNENLETELRHLQ 511
            +ER +  E+++  L+
Sbjct: 1907 EERADIAESQVNKLR 1921



 Score = 63.9 bits (154), Expect = 3e-10
 Identities = 86/460 (18%), Positives = 200/460 (43%), Gaps = 54/460 (11%)

Query: 84   RAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAMKELSTLK----- 138
            ++A+ EK M       A+ +E++++++     +    ++L  K+   ++E + L+     
Sbjct: 841  KSAEREKEM-------ASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQA 893

Query: 139  KKQSLPPQKEALEANVTQDLKLPGFVEESCEHT-DQFQLSSQMHESIREYLVKRQFSTKE 197
            ++ +L   +E  +  +   ++L   V+E  E   D+ ++++++    R+ L       K 
Sbjct: 894  EQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRK-LEDECSELKR 952

Query: 198  DTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGE--TKTGLRLKAINLPLENEVT 255
            D ++ E    +   K+ +E     + V       +G  E   K     KA+    +  + 
Sbjct: 953  DIDDLE----LTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALD 1008

Query: 256  EISA--------------LQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEE 301
            ++ A              L+  +D+ +  L +E+++R  LE+   +LE  L L +    +
Sbjct: 1009 DLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMD 1068

Query: 302  LKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTS 361
            L+  K    ++ D  L + + E+  L+  I++E    +   + + EL+A +E L+ E  +
Sbjct: 1069 LENDK----QQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEA 1124

Query: 362  EWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQ 421
            E   R  +E+ +  L RE   +  +++E       +  ++   ++ +F+  + DL+E   
Sbjct: 1125 ERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREA-EFQKMRRDLEEATL 1183

Query: 422  ELLNLQHAYYKLNRQYQANIAELTHANNRVDQN-EAEVKKLRLRVEELKQGLNQ------ 474
            +      A  K +    A + E      RV Q  E E  + +L ++++   + Q      
Sbjct: 1184 QHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKA 1243

Query: 475  --------KEDELDDSLNQIRKLQRSLDEEKERNENLETE 506
                     ED++++  ++  + QRS+++   +   L+TE
Sbjct: 1244 NLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTE 1283



 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 94/467 (20%), Positives = 186/467 (39%), Gaps = 45/467 (9%)

Query: 78   LEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAMKELST- 136
            +E++    A +EK  R   D     R K  + +   N    +    R KL+    ELS  
Sbjct: 1235 MEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQ----RAKLQTENGELSRQ 1290

Query: 137  LKKKQSLPPQKEALEANVTQ---DLKLPGFVEESCEHTDQFQLSSQMHESIREYLVKRQF 193
            L +K++L  Q    +   TQ   DLK     E   ++     L S  H+     L++ Q+
Sbjct: 1291 LDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCD---LLREQY 1347

Query: 194  STKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLK-------AI 246
              + +   + Q V+  +     + +   +   +         + K   RL+       A+
Sbjct: 1348 EEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAV 1407

Query: 247  NLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELKESK 306
            N    +       LQ  +++    + +      AL+K+    +  L+ WK KYEE +   
Sbjct: 1408 NAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSEL 1467

Query: 307  PKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWDKR 366
              + KE   L    + E+ +L    +E  +   +  R    L+ E+  L  +  S     
Sbjct: 1468 ESSQKEARSL----STELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTI 1523

Query: 367  EILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQ----EKNQE 422
              LE+ ++ LE E   L+  ++E E  L+ +      +Q  +F   + +++    EK++E
Sbjct: 1524 HELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQL-EFNQIKAEIERKLAEKDEE 1582

Query: 423  LLNLQHAYYKLNRQYQANIAELTHANNRV---------DQNEAEVK---------KLRLR 464
            +   +  + ++    Q ++   T + N           D NE E++         + + +
Sbjct: 1583 MEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQ 1642

Query: 465  VEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRHLQ 511
            V+ L+  L   + +LDD++     L+ ++   + RN  L+ EL  L+
Sbjct: 1643 VKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELR 1689



 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 111/520 (21%), Positives = 212/520 (40%), Gaps = 88/520 (16%)

Query: 70   CEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEM 129
            C++L ++   +++A+  +M + +    +  A    K  K+  E +  + +   L + L  
Sbjct: 905  CDQL-IKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAK 963

Query: 130  AMKEL-STLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHT-DQFQLSSQMHESIREY 187
              KE  +T  K ++L  +   L+  + +  K    ++E+ +   D  Q       ++ + 
Sbjct: 964  VEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKA 1023

Query: 188  LVK--RQFSTKEDTNNKEQGVVID----SLKLSEEMKPNLDGVDLFNNGGSGNGET--KT 239
             VK  +Q    E +  +E+ V +D      KL  ++K   + +    N      E   K 
Sbjct: 1024 KVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKK 1083

Query: 240  GLRLKAINLPLENEVT-------EISALQVHLDEFQKILWKEREMRTALEK--------- 283
               L A+N  +E+E         ++  LQ  ++E ++ L  ER  R  +EK         
Sbjct: 1084 DFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSREL 1143

Query: 284  -EI-ERLESALSLWKWKYE--------------ELKESKPKNVKEFDILLGQHNDEMQEL 327
             EI ERLE A      + E              +L+E+  ++      L  +H D + EL
Sbjct: 1144 EEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAEL 1203

Query: 328  SGNI-----------KEESKSQNSKDRV------ICELRAELERL---------QAENTS 361
               I           KE+S+ +   D V      I + +A LE++         +  + +
Sbjct: 1204 GEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKA 1263

Query: 362  EWDKREI--LEREKQGLERENRRLKIQVKEMEELLDK--KNRLSANSQSPDFKMS-QIDL 416
            E  +R +  L  ++  L+ EN  L  Q+ E E L+ +  + +L+   Q  D K   + ++
Sbjct: 1264 EETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEV 1323

Query: 417  QEKN---QELLNLQHAYYKLNRQYQANIAE-------LTHANNRVDQ----NEAEVKKLR 462
            + KN     L + +H    L  QY+            L+ AN+ V Q     E +  +  
Sbjct: 1324 KAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRT 1383

Query: 463  LRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNEN 502
              +EE K+ L Q+  E ++++  +     SL++ K R +N
Sbjct: 1384 EELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQN 1423



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 62/307 (20%), Positives = 125/307 (40%), Gaps = 53/307 (17%)

Query: 204 QGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLENEVTEISALQVH 263
           +G  IDS K +E++  +LD     ++     G TK   +   + L  E     +S +   
Sbjct: 732 EGQFIDSRKGAEKLLSSLD----IDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIITR 787

Query: 264 LDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELKESKPKNVKEFDILLGQHNDE 323
           +    + +    E +  LE+       +L + +W           N++ F   +G  N  
Sbjct: 788 IQAQSRGVLARMEYKKLLERR-----DSLLVIQW-----------NIRAF---MGVKNWP 828

Query: 324 MQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWDKREILEREKQGLERENRRL 383
             +L   IK   KS   +++ +  ++ E  RL                 K+ LE+   R 
Sbjct: 829 WMKLYFKIKPLLKSAE-REKEMASMKEEFTRL-----------------KEALEKSEARR 870

Query: 384 KIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAE 443
           K   ++M  LL +KN L    Q+    ++  D +E+  +L+       K   Q +A + E
Sbjct: 871 KELEEKMVSLLQEKNDLQLQVQAEQDNLA--DAEERCDQLI-------KNKIQLEAKVKE 921

Query: 444 LTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENL 503
           +   N R++  E    +L  +  +L+   ++ + ++DD    + K+++     + + +NL
Sbjct: 922 M---NERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNL 978

Query: 504 ETELRHL 510
             E+  L
Sbjct: 979 TEEMAGL 985


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score = 79.3 bits (194), Expect = 8e-15
 Identities = 106/462 (22%), Positives = 197/462 (42%), Gaps = 69/462 (14%)

Query: 71   EELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMA 130
            EE+  +E E VK R  Q+    R     T       S++ AE+   +E+  Q   +L   
Sbjct: 845  EEMMAKEEELVKVREKQLAAENRLTEMETLQ-----SQLMAEKLQLQEQ-LQAETELCAE 898

Query: 131  MKELST--LKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMH------- 181
             +EL      KKQ L      LEA V ++       EE C+H    +   Q +       
Sbjct: 899  AEELRARLTAKKQELEEICHDLEARVEEE-------EERCQHLQAEKKKMQQNIQELEEQ 951

Query: 182  ----ESIREYLVKRQFSTKEDTNNKEQGVVI---DSLKLSEEMKPNLDGVDLFNNGGSGN 234
                ES R+ L   + +T+      E+  +I    + KL++E K   D +  F    +  
Sbjct: 952  LEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEE 1011

Query: 235  GETKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSL 294
             E    L        L+N+       +  + + ++ L +E + R  LEK   +LE   + 
Sbjct: 1012 EEKSKSLA------KLKNKH------EAMITDLEERLRREEKQRQELEKTRRKLEGDSTD 1059

Query: 295  WKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELER 354
               +  EL+      + E  + L +  +E+Q     ++EE+  +N   + I EL +++  
Sbjct: 1060 LSDQIAELQAQ----IAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISE 1115

Query: 355  LQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQI 414
            LQ +  SE   R   E++K+ L  E   LK    E+E+ LD                +Q 
Sbjct: 1116 LQEDLESERASRNKAEKQKRDLGEELEALK---TELEDTLDS-------------TAAQQ 1159

Query: 415  DLQEKNQELLN-LQHAYYKLNRQYQANIAELTHANNRVDQNEAE----VKKLRLRVEELK 469
            +L+ K ++ +N L+    +  + ++A I E+   +++  +  AE     K+++  +E+ K
Sbjct: 1160 ELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAK 1219

Query: 470  QGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRHLQ 511
            Q L  +  EL    N+++ L +   + + + + +E +L+ LQ
Sbjct: 1220 QTLENERGEL---ANEVKVLLQGKGDSEHKRKKVEAQLQELQ 1258



 Score = 70.5 bits (171), Expect = 4e-12
 Identities = 95/464 (20%), Positives = 199/464 (42%), Gaps = 55/464 (11%)

Query: 75   LRELEEVKARAAQMEKTMRWWSDCTANWREKWSK----VRAERNSAREEGRQLRIKLEMA 130
            L E  E KA   ++ K  R   +   + ++   K    +   + +  ++  +++ +LE  
Sbjct: 1485 LEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEEL 1544

Query: 131  MKEL-STLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQF-----QLSSQMHESI 184
              EL +T   K  L    +A++A   +DL+  G  E+S E   Q      ++ +++ +  
Sbjct: 1545 EDELQATEDAKLRLEVNLQAMKAQFERDLQ--GRDEQSEEKKKQLVRQVREMEAELEDER 1602

Query: 185  REYLV------KRQFSTKE-----DTNNKEQGVVIDSL-KLSEEMKPNLDGVDLFNNGGS 232
            ++  +      K +   K+     D+ NK +   I  L KL  +MK  +  +D       
Sbjct: 1603 KQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELD------- 1655

Query: 233  GNGETKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESAL 292
               +T+   R + +    ENE  ++ +++  + + Q+ L      +   ++E + L   +
Sbjct: 1656 ---DTRAS-REEILAQAKENE-KKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEI 1710

Query: 293  SLWKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGN---IKEESKSQNSK-DRVICEL 348
            +    K     E K    +  +  + Q  +E++E  GN   I +  K  N + D++  +L
Sbjct: 1711 ANSSGKGALALEEK----RRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDL 1766

Query: 349  RAELERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPD 408
               LER  A+           E  +Q LER+N+ LK++++EME  +  K + S  +    
Sbjct: 1767 N--LERSHAQKN---------ENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAK 1815

Query: 409  FKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEEL 468
                +  L  + +E         +  ++ +  + ++       +Q + +  K   R+++L
Sbjct: 1816 IAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQL 1875

Query: 469  KQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRHLQN 512
            K+ L + E+E   +    RKLQR L++  E  + +  E+  L+N
Sbjct: 1876 KRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKN 1919



 Score = 69.3 bits (168), Expect = 8e-12
 Identities = 98/441 (22%), Positives = 189/441 (42%), Gaps = 40/441 (9%)

Query: 79   EEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAMKELSTLK 138
            ++V+A+  +++              +K +K++ E ++      Q   K     K+ S L+
Sbjct: 1248 KKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALE 1307

Query: 139  KKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIREYLVKRQFSTKED 198
             +  L   +E L+    Q L L   +++  +  + F+   +  E  +  L K+  +    
Sbjct: 1308 SQ--LQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQ 1365

Query: 199  TNN--KEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLENEVTE 256
              +  K+    +  L+ +EE+K  L   DL   G S   E K     K     LE   T 
Sbjct: 1366 VADMKKKMEDSVGCLETAEEVKRKLQK-DL--EGLSQRHEEKVAAYDK-----LEKTKTR 1417

Query: 257  ISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKW---KYEELKESKPKNVKEF 313
               LQ  LD+    L  +R+    LEK+ ++ +  L+  K    KY E ++      +E 
Sbjct: 1418 ---LQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREK 1474

Query: 314  DILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWDKREILEREK 373
            +        +   L+  ++E  + +   +R+  + R E+E L +           LE+ K
Sbjct: 1475 ET-------KALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSK 1527

Query: 374  QGLERENRRLKIQVKEMEELL----DKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHA 429
            + LE++   +K Q++E+E+ L    D K RL  N Q+   +  + DLQ ++++    +  
Sbjct: 1528 RALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFER-DLQGRDEQ---SEEK 1583

Query: 430  YYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKL 489
              +L RQ +   AEL     +     A  KKL + +++L+  ++      D+++ Q+RKL
Sbjct: 1584 KKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKL 1643

Query: 490  Q-------RSLDEEKERNENL 503
            Q       R LD+ +   E +
Sbjct: 1644 QAQMKDCMRELDDTRASREEI 1664


>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score = 79.3 bits (194), Expect = 8e-15
 Identities = 107/512 (20%), Positives = 222/512 (43%), Gaps = 87/512 (16%)

Query: 71   EELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKL--- 127
            E+L L ++E   A  A ++K  R +    A W++K  +  AE  ++++E R L  +L   
Sbjct: 1432 EDLML-DVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKI 1490

Query: 128  ----EMAMKELSTLKKKQSLPPQK------------------EALEANVTQD-LKLPGFV 164
                E ++ +L TLK++     Q+                  E ++  V Q+  +L   +
Sbjct: 1491 KNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAAL 1550

Query: 165  EE---SCEHTD------QFQLSSQMHESIREYLVK------------RQFSTKEDTNNKE 203
            EE   S EH +      Q +L+    E  R+   K            R   + + T + E
Sbjct: 1551 EEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAE 1610

Query: 204  QGVVIDSLKLSEEMKPNLDGVDL-FNNGGSGNGETKTGLR-----LKAINLPLENEVTE- 256
                 D+++L ++M+ +L+ +++  N+      E     R     LK   + L++ +   
Sbjct: 1611 IRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQ 1670

Query: 257  -------------ISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELK 303
                          + LQ  ++E +  L +    R   E+E+      + L   +   L 
Sbjct: 1671 EDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLI 1730

Query: 304  ESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEW 363
             +K K   +   + G+  D +QE + N +E++K   +   ++ E          E   E 
Sbjct: 1731 NTKKKLETDISQMQGEMEDILQE-ARNAEEKAKKAITDAAMMAE----------ELKKEQ 1779

Query: 364  DKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQEL 423
            D    LER K+ +E+  + L++++ E E+L  K  +     Q  + ++ +++ + ++++ 
Sbjct: 1780 DTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQI--QKLEARVRELEGEVESEQK 1837

Query: 424  LNLQHAYYKLNRQYQANIAELTHANNRVDQN----EAEVKKLRLRVEELKQGLNQKEDEL 479
             N +    K  R+++  + ELT+      +N    +  V KL+ +V+  K+   + E++ 
Sbjct: 1838 RNAEAV--KGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQS 1895

Query: 480  DDSLNQIRKLQRSLDEEKERNENLETELRHLQ 511
            + +L + RKLQ  L+E +ER +  E+++  L+
Sbjct: 1896 NTNLAKFRKLQHELEEAEERADIAESQVNKLR 1927



 Score = 66.6 bits (161), Expect = 5e-11
 Identities = 87/449 (19%), Positives = 202/449 (44%), Gaps = 53/449 (11%)

Query: 84   RAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAMKELSTLK----- 138
            ++A+ EK M       A  +E++ K++ E   +  + ++L  K+   +KE + L+     
Sbjct: 847  KSAETEKEM-------ATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQA 899

Query: 139  KKQSLPPQKEALEANVTQDLKLPGFVEESCEHT-DQFQLSSQMHESIREYLVKRQFSTKE 197
            + + L   +E  +  +   ++L   ++E  E   D+ ++++++    R+ L       K+
Sbjct: 900  EAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRK-LEDECSELKK 958

Query: 198  DTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGET--KTGLRLKAINLPLENEVT 255
            D ++ E    +   K+ +E     + V       +G  ET  K     KA+    +  + 
Sbjct: 959  DIDDLE----LTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLD 1014

Query: 256  EISA--------------LQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEE 301
            ++ A              L+  +D+ +  L +E+++R  LE+   +LE  L L +    +
Sbjct: 1015 DLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMD 1074

Query: 302  LKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTS 361
            ++  K    ++ D  L +   E+  L   I++E        + I EL+A +E L+ E  +
Sbjct: 1075 IENEK----QQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEA 1130

Query: 362  EWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQ 421
            E   R   E+++  L RE   +  +++E       +  ++   ++ +F+  + DL+E   
Sbjct: 1131 ERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREA-EFQKMRRDLEEAT- 1188

Query: 422  ELLNLQH--AYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDEL 479
                LQH      L +++  ++AEL     ++D     +++++ ++E+ K  +  + D+L
Sbjct: 1189 ----LQHEATAATLRKKHADSVAEL---GEQIDN----LQRVKQKLEKEKSEMKMEIDDL 1237

Query: 480  DDSLNQIRKLQRSLDEEKERNENLETELR 508
              ++  + K + +L++     E+  +EL+
Sbjct: 1238 ASNVETVSKAKGNLEKMCRTLEDQLSELK 1266



 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 97/473 (20%), Positives = 196/473 (41%), Gaps = 70/473 (14%)

Query: 77   ELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAER-NSAREEGRQLRIKLEMAMKELS 135
            ++E  K R A+ +K  R   + T       + +R +  +S  E G Q+   L+   ++L 
Sbjct: 1166 QIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQID-NLQRVKQKLE 1224

Query: 136  TLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIREYLVKRQFST 195
              K+K  +  + + L +NV    K  G +E+ C  T + QLS    +   +  +    + 
Sbjct: 1225 --KEKSEMKMEIDDLASNVETVSKAKGNLEKMCR-TLEDQLSELKSKEEEQQRLINDLTA 1281

Query: 196  KEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLENEVT 255
            +      E G     L   E +   L             G+     +++ +   LE E+ 
Sbjct: 1282 QRGRLQTESGEFSRQLDEKEALVSQLS-----------RGKQAFTQQIEELKRQLEEEIK 1330

Query: 256  EISALQVHL-------DEFQKILWKEREMRTALEKEIERLESALSLWKWKY--------E 300
              +AL   L       D  ++   +E+E +  L++ + +  + ++ W+ KY        E
Sbjct: 1331 AKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTE 1390

Query: 301  ELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENT 360
            EL+E+K K  +     L    + ++ ++       K++      + +L  ++ER  A   
Sbjct: 1391 ELEEAKKKLAQR----LQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAA-C 1445

Query: 361  SEWDKRE-----ILEREKQGLERENRRLKIQVKE--------------MEELLDKKNRLS 401
            +  DK++     IL   KQ  E  +  L+   KE               EE LD+   L 
Sbjct: 1446 AALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLK 1505

Query: 402  ANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAE----LTHANNRVDQNEAE 457
              +++   ++S  DL E+  E     H   K+ +Q +    E    L  A   ++  E +
Sbjct: 1506 RENKNLQQEIS--DLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGK 1563

Query: 458  VKKLRLRVEELKQGLNQKEDELDDSLNQIRK--------LQRSLDEE-KERNE 501
            + +++L + ++K  +++K  E D+ ++Q+++        +Q +LD E + RN+
Sbjct: 1564 ILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRND 1616



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 102/502 (20%), Positives = 205/502 (40%), Gaps = 90/502 (17%)

Query: 68   DICEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWS-------KVRAERNSAREEG 120
            D C EL+ +++++++   A++EK      +   N  E+ +       K+  E+ + +E  
Sbjct: 951  DECSELK-KDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAH 1009

Query: 121  RQLRIKLEMAMKELSTLKK-KQSLPPQKEALEANVTQDLKLPGFVEESCEHTD-QFQLSS 178
            +Q    L+    +++TL K K  L  Q + LE ++ Q+ KL   +E +    +   +L+ 
Sbjct: 1010 QQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQ 1069

Query: 179  QM-------HESIREYLVKRQF--STKEDTNNKEQGVVIDSLKLSEEMKPNLDGVD---- 225
            +         + + E L K++F  S  +     EQ + I   K  +E++  ++ ++    
Sbjct: 1070 ESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIE 1129

Query: 226  --------------------------LFNNGGSGNGETKTGLRLKAI---------NLPL 250
                                      L   GG+ + + +   + +A             L
Sbjct: 1130 AERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATL 1189

Query: 251  ENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELKESKPKNV 310
            ++E T  +  + H D   ++     E    L++  ++LE   S  K + ++L      NV
Sbjct: 1190 QHEATAATLRKKHADSVAEL----GEQIDNLQRVKQKLEKEKSEMKMEIDDLAS----NV 1241

Query: 311  KEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAEN---TSEWDKRE 367
            +      G      + L   + E    +  + R+I +L A+  RLQ E+   + + D++E
Sbjct: 1242 ETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKE 1301

Query: 368  IL----EREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSP--DFKMSQIDLQEKNQ 421
             L     R KQ   ++   LK   +++EE +  KN L+   QS   D  + +   +E+ +
Sbjct: 1302 ALVSQLSRGKQAFTQQIEELK---RQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQE 1358

Query: 422  ELLNLQHAYYKLNRQY-QANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELD 480
                LQ A  K N +  Q      T A  R ++           +EE K+ L Q+    +
Sbjct: 1359 SKAELQRALSKANTEVAQWRTKYETDAIQRTEE-----------LEEAKKKLAQRLQAAE 1407

Query: 481  DSLNQIRKLQRSLDEEKERNEN 502
            + +  +     SL++ K+R +N
Sbjct: 1408 EHVEAVNAKCASLEKTKQRLQN 1429


>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score = 79.3 bits (194), Expect = 8e-15
 Identities = 107/512 (20%), Positives = 222/512 (43%), Gaps = 87/512 (16%)

Query: 71   EELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKL--- 127
            E+L L ++E   A  A ++K  R +    A W++K  +  AE  ++++E R L  +L   
Sbjct: 1432 EDLML-DVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKI 1490

Query: 128  ----EMAMKELSTLKKKQSLPPQK------------------EALEANVTQD-LKLPGFV 164
                E ++ +L TLK++     Q+                  E ++  V Q+  +L   +
Sbjct: 1491 KNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAAL 1550

Query: 165  EE---SCEHTD------QFQLSSQMHESIREYLVK------------RQFSTKEDTNNKE 203
            EE   S EH +      Q +L+    E  R+   K            R   + + T + E
Sbjct: 1551 EEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAE 1610

Query: 204  QGVVIDSLKLSEEMKPNLDGVDL-FNNGGSGNGETKTGLR-----LKAINLPLENEVTE- 256
                 D+++L ++M+ +L+ +++  N+      E     R     LK   + L++ +   
Sbjct: 1611 IRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQ 1670

Query: 257  -------------ISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELK 303
                          + LQ  ++E +  L +    R   E+E+      + L   +   L 
Sbjct: 1671 EDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLI 1730

Query: 304  ESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEW 363
             +K K   +   + G+  D +QE + N +E++K   +   ++ E          E   E 
Sbjct: 1731 NTKKKLETDISQMQGEMEDILQE-ARNAEEKAKKAITDAAMMAE----------ELKKEQ 1779

Query: 364  DKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQEL 423
            D    LER K+ +E+  + L++++ E E+L  K  +     Q  + ++ +++ + ++++ 
Sbjct: 1780 DTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQI--QKLEARVRELEGEVESEQK 1837

Query: 424  LNLQHAYYKLNRQYQANIAELTHANNRVDQN----EAEVKKLRLRVEELKQGLNQKEDEL 479
             N +    K  R+++  + ELT+      +N    +  V KL+ +V+  K+   + E++ 
Sbjct: 1838 RNAEAV--KGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQS 1895

Query: 480  DDSLNQIRKLQRSLDEEKERNENLETELRHLQ 511
            + +L + RKLQ  L+E +ER +  E+++  L+
Sbjct: 1896 NTNLAKFRKLQHELEEAEERADIAESQVNKLR 1927



 Score = 66.6 bits (161), Expect = 5e-11
 Identities = 87/449 (19%), Positives = 202/449 (44%), Gaps = 53/449 (11%)

Query: 84   RAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAMKELSTLK----- 138
            ++A+ EK M       A  +E++ K++ E   +  + ++L  K+   +KE + L+     
Sbjct: 847  KSAETEKEM-------ATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQA 899

Query: 139  KKQSLPPQKEALEANVTQDLKLPGFVEESCEHT-DQFQLSSQMHESIREYLVKRQFSTKE 197
            + + L   +E  +  +   ++L   ++E  E   D+ ++++++    R+ L       K+
Sbjct: 900  EAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRK-LEDECSELKK 958

Query: 198  DTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGET--KTGLRLKAINLPLENEVT 255
            D ++ E    +   K+ +E     + V       +G  ET  K     KA+    +  + 
Sbjct: 959  DIDDLE----LTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLD 1014

Query: 256  EISA--------------LQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEE 301
            ++ A              L+  +D+ +  L +E+++R  LE+   +LE  L L +    +
Sbjct: 1015 DLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMD 1074

Query: 302  LKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTS 361
            ++  K    ++ D  L +   E+  L   I++E        + I EL+A +E L+ E  +
Sbjct: 1075 IENEK----QQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEA 1130

Query: 362  EWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQ 421
            E   R   E+++  L RE   +  +++E       +  ++   ++ +F+  + DL+E   
Sbjct: 1131 ERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREA-EFQKMRRDLEEAT- 1188

Query: 422  ELLNLQH--AYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDEL 479
                LQH      L +++  ++AEL     ++D     +++++ ++E+ K  +  + D+L
Sbjct: 1189 ----LQHEATAATLRKKHADSVAEL---GEQIDN----LQRVKQKLEKEKSEMKMEIDDL 1237

Query: 480  DDSLNQIRKLQRSLDEEKERNENLETELR 508
              ++  + K + +L++     E+  +EL+
Sbjct: 1238 ASNVETVSKAKGNLEKMCRTLEDQLSELK 1266



 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 97/473 (20%), Positives = 196/473 (41%), Gaps = 70/473 (14%)

Query: 77   ELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAER-NSAREEGRQLRIKLEMAMKELS 135
            ++E  K R A+ +K  R   + T       + +R +  +S  E G Q+   L+   ++L 
Sbjct: 1166 QIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQID-NLQRVKQKLE 1224

Query: 136  TLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIREYLVKRQFST 195
              K+K  +  + + L +NV    K  G +E+ C  T + QLS    +   +  +    + 
Sbjct: 1225 --KEKSEMKMEIDDLASNVETVSKAKGNLEKMCR-TLEDQLSELKSKEEEQQRLINDLTA 1281

Query: 196  KEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLENEVT 255
            +      E G     L   E +   L             G+     +++ +   LE E+ 
Sbjct: 1282 QRGRLQTESGEFSRQLDEKEALVSQLS-----------RGKQAFTQQIEELKRQLEEEIK 1330

Query: 256  EISALQVHL-------DEFQKILWKEREMRTALEKEIERLESALSLWKWKY--------E 300
              +AL   L       D  ++   +E+E +  L++ + +  + ++ W+ KY        E
Sbjct: 1331 AKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTE 1390

Query: 301  ELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENT 360
            EL+E+K K  +     L    + ++ ++       K++      + +L  ++ER  A   
Sbjct: 1391 ELEEAKKKLAQR----LQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAA-C 1445

Query: 361  SEWDKRE-----ILEREKQGLERENRRLKIQVKE--------------MEELLDKKNRLS 401
            +  DK++     IL   KQ  E  +  L+   KE               EE LD+   L 
Sbjct: 1446 AALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLK 1505

Query: 402  ANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAE----LTHANNRVDQNEAE 457
              +++   ++S  DL E+  E     H   K+ +Q +    E    L  A   ++  E +
Sbjct: 1506 RENKNLQQEIS--DLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGK 1563

Query: 458  VKKLRLRVEELKQGLNQKEDELDDSLNQIRK--------LQRSLDEE-KERNE 501
            + +++L + ++K  +++K  E D+ ++Q+++        +Q +LD E + RN+
Sbjct: 1564 ILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRND 1616



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 102/502 (20%), Positives = 205/502 (40%), Gaps = 90/502 (17%)

Query: 68   DICEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWS-------KVRAERNSAREEG 120
            D C EL+ +++++++   A++EK      +   N  E+ +       K+  E+ + +E  
Sbjct: 951  DECSELK-KDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAH 1009

Query: 121  RQLRIKLEMAMKELSTLKK-KQSLPPQKEALEANVTQDLKLPGFVEESCEHTD-QFQLSS 178
            +Q    L+    +++TL K K  L  Q + LE ++ Q+ KL   +E +    +   +L+ 
Sbjct: 1010 QQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQ 1069

Query: 179  QM-------HESIREYLVKRQF--STKEDTNNKEQGVVIDSLKLSEEMKPNLDGVD---- 225
            +         + + E L K++F  S  +     EQ + I   K  +E++  ++ ++    
Sbjct: 1070 ESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIE 1129

Query: 226  --------------------------LFNNGGSGNGETKTGLRLKAI---------NLPL 250
                                      L   GG+ + + +   + +A             L
Sbjct: 1130 AERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATL 1189

Query: 251  ENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELKESKPKNV 310
            ++E T  +  + H D   ++     E    L++  ++LE   S  K + ++L      NV
Sbjct: 1190 QHEATAATLRKKHADSVAEL----GEQIDNLQRVKQKLEKEKSEMKMEIDDLAS----NV 1241

Query: 311  KEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAEN---TSEWDKRE 367
            +      G      + L   + E    +  + R+I +L A+  RLQ E+   + + D++E
Sbjct: 1242 ETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKE 1301

Query: 368  IL----EREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSP--DFKMSQIDLQEKNQ 421
             L     R KQ   ++   LK   +++EE +  KN L+   QS   D  + +   +E+ +
Sbjct: 1302 ALVSQLSRGKQAFTQQIEELK---RQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQE 1358

Query: 422  ELLNLQHAYYKLNRQY-QANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELD 480
                LQ A  K N +  Q      T A  R ++           +EE K+ L Q+    +
Sbjct: 1359 SKAELQRALSKANTEVAQWRTKYETDAIQRTEE-----------LEEAKKKLAQRLQAAE 1407

Query: 481  DSLNQIRKLQRSLDEEKERNEN 502
            + +  +     SL++ K+R +N
Sbjct: 1408 EHVEAVNAKCASLEKTKQRLQN 1429


>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
            sapiens]
          Length = 1939

 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 103/513 (20%), Positives = 217/513 (42%), Gaps = 100/513 (19%)

Query: 77   ELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKL-------EM 129
            ++E   A    ++K  R +    A W++K+ + +AE  ++++E R L  +L       E 
Sbjct: 1435 DVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEE 1494

Query: 130  AMKELSTLKK-----------------------------KQSLPPQKEALEANVTQDLKL 160
            ++  L TLK+                             K+ L  +K  L+ ++ +    
Sbjct: 1495 SLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEE---- 1550

Query: 161  PGFVEESCEHTD------QFQLSSQMHESIREYLVK------------RQFSTKEDTNNK 202
                E S EH +      Q +L+    E  R+   K            R   + + T + 
Sbjct: 1551 ---AEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDA 1607

Query: 203  EQGVVIDSLKLSEEMKPNLDGVDL-FNNGGSGNGETKTGLR-----LKAINLPLENEVT- 255
            E     D+L++ ++M+ +L+ +++  N+      E    LR     LK   L L++ +  
Sbjct: 1608 EIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRG 1667

Query: 256  -------------EISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEEL 302
                           + +Q  ++E +  L +    R   E+E+      + L   +   L
Sbjct: 1668 QDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSL 1727

Query: 303  KESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSE 362
              +K K   +   + G+  D +QE + N +E++K   +   ++ E          E   E
Sbjct: 1728 INTKKKLETDISQIQGEMEDIVQE-ARNAEEKAKKAITDAAMMAE----------ELKKE 1776

Query: 363  WDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQE 422
             D    LER K+ +E+  + L++++ E E+L  K  +     Q  + ++ +++ + ++++
Sbjct: 1777 QDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQI--QKLEARVRELESEVESEQ 1834

Query: 423  LLNLQHAYYKLNRQYQANIAELTHANNRVDQN----EAEVKKLRLRVEELKQGLNQKEDE 478
              N++    K  R+++  + ELT+      +N    +  V KL+ +V+  K+   + E++
Sbjct: 1835 KHNVEAV--KGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAEEAEEQ 1892

Query: 479  LDDSLNQIRKLQRSLDEEKERNENLETELRHLQ 511
             + +L + RKLQ  L+E KER +  E+++  L+
Sbjct: 1893 SNVNLAKFRKLQHELEEAKERADIAESQVNKLR 1925



 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 48/236 (20%), Positives = 110/236 (46%), Gaps = 9/236 (3%)

Query: 273  KEREMRTALEKEIERLESALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIK 332
            K +E+    E E E + + L+  K K E+      K++ + ++ L +   E       +K
Sbjct: 922  KIKEVTERAEDE-EEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVK 980

Query: 333  EESKSQNSKDRVICELRAELERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEE 392
              ++     D  I +L  E + LQ  +    D  ++ E +   L +   +L+ QV ++E 
Sbjct: 981  NLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEG 1040

Query: 393  LLDKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVD 452
             L+++ +L  + +    K+   DL+   +  ++ ++   +LN + +    E+++   +++
Sbjct: 1041 SLEQEKKLCMDLERAKRKLEG-DLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIE 1099

Query: 453  QNEAEVKKLRLRVEELKQGLNQKEDELD-------DSLNQIRKLQRSLDEEKERNE 501
              +A   +L+ +++EL+  + + E+E++        +  Q   L R L+E  ER E
Sbjct: 1100 DEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLE 1155



 Score = 56.6 bits (135), Expect = 5e-08
 Identities = 110/513 (21%), Positives = 206/513 (40%), Gaps = 112/513 (21%)

Query: 68   DICEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWS-------KVRAERNSAREEG 120
            D C EL+ +++++++   A++EK      +   N  E+ +       K+  E+ + +E  
Sbjct: 949  DECSELK-KDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAH 1007

Query: 121  RQLRIKLEMAMKELSTLKK-KQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQ 179
            +Q    L+M   +++TL K K  L  Q + LE ++ Q+ KL   +E +            
Sbjct: 1008 QQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERA------------ 1055

Query: 180  MHESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKT 239
                +   L   Q ST +  N+K+Q        L+E++K      ++ N  G    E   
Sbjct: 1056 -KRKLEGDLKLAQESTMDTENDKQQ--------LNEKLKKK--EFEMSNLQGKIEDE--- 1101

Query: 240  GLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKE-----------IERL 288
                +A+ + L+ ++ E   LQ  ++E ++ +  ER  R   EK+            ERL
Sbjct: 1102 ----QALAIQLQKKIKE---LQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERL 1154

Query: 289  ESALSLWKWKYE--------------ELKESKPKNVKEFDILLGQHNDEMQELSGNIKEE 334
            E A      + E              +L+ES  ++      L  +H D + EL   I   
Sbjct: 1155 EEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSL 1214

Query: 335  SKSQNSKDRVICELRAELERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEELL 394
             + +   ++   EL+ E+  L +   +    +   E+  + LE +   +K + +E + L+
Sbjct: 1215 QRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLI 1274

Query: 395  D----KKNRLSANS-------QSPDFKMSQI----------------DLQEKNQELLNLQ 427
            +    +K RL   S          D  +SQ+                 L+E+ +    L 
Sbjct: 1275 NELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLA 1334

Query: 428  HAYYK-------LNRQY---QANIAEL----THANNRVDQ----NEAEVKKLRLRVEELK 469
            HA          L  QY   Q   AEL    + AN+ V Q     E +  +    +EE K
Sbjct: 1335 HALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAK 1394

Query: 470  QGLNQKEDELDDSLNQIRKLQRSLDEEKERNEN 502
            + L Q+  + ++ +  +     SL++ K+R +N
Sbjct: 1395 KKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQN 1427



 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 105/524 (20%), Positives = 206/524 (39%), Gaps = 110/524 (20%)

Query: 78   LEEVKARAAQMEKTMRWWSDCTANWREKW-------SKVRAERNSAREEGRQLRIKLEMA 130
            +E V    A  EK  R   D  +  + K        +++ A++     E  +   +L+  
Sbjct: 1239 METVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEK 1298

Query: 131  MKELSTLKK-KQSLPPQKEALEANVTQDLKLPGFVE---ESCEHT-----DQFQLSSQMH 181
               +S L + KQ+   Q E L+  + ++ K    +    +S  H      +Q++   +  
Sbjct: 1299 DAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAK 1358

Query: 182  ESIREYLVKR-----QFSTKEDTNNKEQGVVIDSLK--LSEEMKPNLDGVDLFNNGGSGN 234
              ++  + K      Q+ TK +T+  ++   ++  K  L++ ++   + V+  N+  +  
Sbjct: 1359 AELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASL 1418

Query: 235  GETKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSL 294
             +TK  L+ +  +L ++ E +  + +                   AL+K+    +  L+ 
Sbjct: 1419 EKTKQRLQNEVEDLMIDVERSNAACI-------------------ALDKKQRNFDKVLAE 1459

Query: 295  WKWKYEEL--------KES--------KPKNVKE-----FDILLGQHNDEMQELSG---- 329
            WK KYEE         KES        K KN  E      + L  ++ +  QE+S     
Sbjct: 1460 WKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQ 1519

Query: 330  ------NIKEESKSQNSKDRVICELRAELERLQAENTSEWDK----------------RE 367
                  +I E  K +   D    EL+  LE  +A    E  K                R+
Sbjct: 1520 IAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRK 1579

Query: 368  ILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANS------QSPDFKMSQIDLQEKNQ 421
            I E++++  + +   L++ V+ M+  LD + R   ++         D    +I L   N+
Sbjct: 1580 IAEKDEELDQLKRNHLRV-VESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANR 1638

Query: 422  E----LLNLQHAYYKL-NRQYQANIA---------ELTHANNRVDQNEAEVKKLRLRVEE 467
            +    L NL++    L + Q   + A         +L     R +  +AEV++LR  +E 
Sbjct: 1639 QAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLER 1698

Query: 468  LKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRHLQ 511
             ++G    E EL D+  +++ L           + LET++  +Q
Sbjct: 1699 TERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQ 1742



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 36/170 (21%), Positives = 86/170 (50%), Gaps = 7/170 (4%)

Query: 342  DRVICELRAELERLQAENTSEWDKREILEREKQGLERENRRLKIQVK-EMEELLDKKNR- 399
            ++ +  ++ E E+ + E      KR+ LE +   L +E   L++QV+ E + L D + R 
Sbjct: 850  EKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAEERC 909

Query: 400  --LSANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAE 457
              L       + K+ ++  + +++E +N +    K  R+ +   +EL    + ++   A+
Sbjct: 910  DQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKK--RKLEDECSELKKDIDDLELTLAK 967

Query: 458  VKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERN-ENLETE 506
            V+K +   E   + L ++   LD+++ ++ K +++L E  ++  ++L+ E
Sbjct: 968  VEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQME 1017


>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
            sapiens]
          Length = 1939

 Score = 77.4 bits (189), Expect = 3e-14
 Identities = 104/494 (21%), Positives = 220/494 (44%), Gaps = 62/494 (12%)

Query: 77   ELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKL-------EM 129
            ++E   A  A ++K  R +    A W++K  +  AE  ++++E R L  +L       E 
Sbjct: 1435 DVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEE 1494

Query: 130  AMKELSTLKKKQSLPPQK------------------EALEANVTQDL-KLPGFVEE---S 167
            ++ +L TLK++     Q+                  E ++  V Q+  +L   +EE   S
Sbjct: 1495 SLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEAS 1554

Query: 168  CEHTDQFQLSSQMHESIREYLVKRQFSTKE---DTNNKEQGVVIDSLK--LSEEMKPNLD 222
             EH +   L  Q+  +  +  V R+ + K+   D   +    +++S++  L  E++   D
Sbjct: 1555 LEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRND 1614

Query: 223  GVDLFNNGGSGNGETKTGL----RLKAINLP-LENEVTEISALQVHLDEFQKILWKEREM 277
             + L         E +  L    R+ A  L    N    +   Q+HLD+  +     +E 
Sbjct: 1615 AIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQ 1674

Query: 278  RTALEK-------EIERLESALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGN 330
               +E+       EIE L + L   + +  ++ E +  +  E   LL   N  +      
Sbjct: 1675 LAMVERRANLLQAEIEELRATLEQTE-RSRKIAEQELLDASERVQLLHTQNTSLINTKKK 1733

Query: 331  IKEE-SKSQNSKDRVICELRAELERLQAENTSEWDKREILEREKQG---LERENRRLKIQ 386
            ++ + S+ Q   + +I E R   E+ +   T      E L++E+     LER  + L+  
Sbjct: 1734 LETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQT 1793

Query: 387  VKEMEELLDKKNRLSANS-----QSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANI 441
            VK+++  LD+  +L+        Q  + ++ +++ + ++++  N++    K  R+++  +
Sbjct: 1794 VKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAV--KGLRKHERKV 1851

Query: 442  AELTHANNRVDQN----EAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEK 497
             ELT+      +N    +  V KL+ +V+  K+   + E++ + +L++ R++Q  L+E +
Sbjct: 1852 KELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAE 1911

Query: 498  ERNENLETELRHLQ 511
            ER +  E+++  L+
Sbjct: 1912 ERADIAESQVNKLR 1925



 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 103/480 (21%), Positives = 206/480 (42%), Gaps = 84/480 (17%)

Query: 77   ELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAER-NSAREEGRQLRIKLEMAMKELS 135
            ++E  K R A+ +K  R   + T       + +R +  +S  E G Q+   L+   ++L 
Sbjct: 1164 QIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQID-NLQRVKQKLE 1222

Query: 136  TLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIREYLVKRQFST 195
              K+K  +  + + L +N+    K  G +E+ C   +  QLS              +  T
Sbjct: 1223 --KEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALED-QLS--------------EIKT 1265

Query: 196  KEDTNNKEQGVVIDSLKL--------SEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAIN 247
            KE+    EQ  +I+ L          S E    LD  D   +  S  G+     +++ + 
Sbjct: 1266 KEE----EQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLS-RGKQAFTQQIEELK 1320

Query: 248  LPLENEVTEISALQVHL-------DEFQKILWKEREMRTALEKEIERLESALSLWKWKY- 299
              LE E+   SAL   L       D  ++   +E+E +  L++ + +  S ++ W+ KY 
Sbjct: 1321 RQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYE 1380

Query: 300  -------EELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAEL 352
                   EEL+E+K K  +     L    + ++ ++       K++      + +L  ++
Sbjct: 1381 TDAIQRTEELEEAKKKLAQR----LQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDV 1436

Query: 353  ERLQA-------------ENTSEW-DKREILEREKQGLERENRRLKIQVKEM----EELL 394
            ER  A             +  +EW  K E    E +  ++E+R L  ++ ++    EE L
Sbjct: 1437 ERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESL 1496

Query: 395  DKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAE----LTHANNR 450
            D+   L   +++   ++S  DL E+  E     H   K+ +Q +   +E    L  A   
Sbjct: 1497 DQLETLKRENKNLQQEIS--DLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEAS 1554

Query: 451  VDQNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRK--------LQRSLDEE-KERNE 501
            ++  E ++ +++L + ++K  +++K  E D+ ++Q+++        +Q +LD E + RN+
Sbjct: 1555 LEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRND 1614



 Score = 53.1 bits (126), Expect = 6e-07
 Identities = 84/409 (20%), Positives = 171/409 (41%), Gaps = 48/409 (11%)

Query: 118  EEGRQLRIKLEMAMKELS-TLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHT--DQF 174
            E+ +++R+ LE A ++L   LK  Q      E  +  + + LK   F     +    D+ 
Sbjct: 1043 EQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQ 1102

Query: 175  QLSSQMHESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVD--LFNNGGS 232
             L  Q+ + I+E  ++ +    E+    E+     + K   ++   L+ +   L   GG+
Sbjct: 1103 ALGMQLQKKIKE--LQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGA 1160

Query: 233  GNGETKTGLRLKAI---------NLPLENEVTEISALQVHLDEFQKILWKEREMRTALEK 283
             + + +   + +A             L++E T  +  + H D   ++     E    L++
Sbjct: 1161 TSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAEL----GEQIDNLQR 1216

Query: 284  EIERLESALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDR 343
              ++LE   S  K + ++L      N++      G      + L   + E    +  + R
Sbjct: 1217 VKQKLEKEKSEMKMEIDDLAS----NMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQR 1272

Query: 344  VICELRAELERLQAEN---TSEWDKREIL----EREKQGLERENRRLKIQVKEMEELLDK 396
            +I +L A+  RLQ E+   + + D+++ L     R KQ   ++   LK   +++EE +  
Sbjct: 1273 LINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELK---RQLEEEIKA 1329

Query: 397  KNRLSANSQSP--DFKMSQIDLQEKNQELLNLQHAYYKLNRQY-QANIAELTHANNRVDQ 453
            K+ L+   QS   D  + +   +E+ +    LQ A  K N +  Q      T A  R ++
Sbjct: 1330 KSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEE 1389

Query: 454  NEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNEN 502
                       +EE K+ L Q+  + ++ +  +     SL++ K+R +N
Sbjct: 1390 -----------LEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQN 1427



 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 92/484 (19%), Positives = 198/484 (40%), Gaps = 76/484 (15%)

Query: 68   DICEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWS-------KVRAERNSAREEG 120
            D C EL+ +++++++   A++EK      +   N  E+ +       K+  E+ + +E  
Sbjct: 949  DECSELK-KDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAH 1007

Query: 121  RQLRIKLEMAMKELSTLKK-KQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQ 179
            +Q    L+    +++TL K K  L  Q + LE ++ Q+ K+   +E +            
Sbjct: 1008 QQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERA------------ 1055

Query: 180  MHESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKT 239
                +   L   Q ST +  N+K+Q        L E++K      +   +G     E + 
Sbjct: 1056 -KRKLEGDLKLAQESTMDIENDKQQ--------LDEKLKKK----EFEMSGLQSKIEDE- 1101

Query: 240  GLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKE-----------IERL 288
                +A+ + L+ ++ E   LQ  ++E ++ +  ER  R   EK+            ERL
Sbjct: 1102 ----QALGMQLQKKIKE---LQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERL 1154

Query: 289  ESALSLWKWKYE--------------ELKESKPKNVKEFDILLGQHNDEMQELSGNIKEE 334
            E A      + E              +L+E+  ++      L  +H D + EL   I   
Sbjct: 1155 EEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNL 1214

Query: 335  SKSQNSKDRVICELRAELERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEELL 394
             + +   ++   E++ E++ L +   +    +  LE+  + LE +   +K + +E + L+
Sbjct: 1215 QRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLI 1274

Query: 395  DKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHA-------YYKLNRQYQANIAELTHA 447
            +      A  Q+   + S+  L EK+  +  L            +L RQ +  I   +  
Sbjct: 1275 NDLTAQRARLQTESGEYSR-QLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSAL 1333

Query: 448  NNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEK-ERNENLETE 506
             + +  +  +   LR + EE ++   + +  +  + +++ + +   + +  +R E LE  
Sbjct: 1334 AHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEA 1393

Query: 507  LRHL 510
             + L
Sbjct: 1394 KKKL 1397



 Score = 42.7 bits (99), Expect = 8e-04
 Identities = 64/308 (20%), Positives = 137/308 (44%), Gaps = 31/308 (10%)

Query: 204  QGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLENEVTEISALQVH 263
            +G  IDS K SE++  ++D     ++     G TK   +   + L  E    +++ L   
Sbjct: 736  EGQFIDSKKASEKLLGSID----IDHTQYKFGHTKVFFKAGLLGLLEEMRDEKLAQLITR 791

Query: 264  LDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELKESKPKNVKEFDILLGQHNDE 323
                 + + +    R   +K +ER ES   +              NV+ F   +   +  
Sbjct: 792  T----QAMCRGFLARVEYQKMVERRESIFCI------------QYNVRAF---MNVKHWP 832

Query: 324  MQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWDKREILEREKQGLERENRRL 383
              +L   IK   KS  + ++ +  ++ E E+ + E      KR+ LE +   L +E   L
Sbjct: 833  WMKLYFKIKPLLKSAET-EKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDL 891

Query: 384  KIQVK-EMEELLDKKNR---LSANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQA 439
            ++QV+ E + L D + R   L       + K+ ++  + +++E +N +    K  R+ + 
Sbjct: 892  QLQVQAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKK--RKLED 949

Query: 440  NIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKER 499
              +EL    + ++   A+V+K +   E   + L ++   LD+++ ++ K +++L E  ++
Sbjct: 950  ECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQ 1009

Query: 500  N-ENLETE 506
              ++L+ E
Sbjct: 1010 TLDDLQAE 1017


>gi|156104908 myosin heavy chain 6 [Homo sapiens]
          Length = 1939

 Score = 77.0 bits (188), Expect = 4e-14
 Identities = 103/494 (20%), Positives = 214/494 (43%), Gaps = 62/494 (12%)

Query: 77   ELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKL-------EM 129
            ++E   A AA ++K  R +    A W++K+ + ++E  S+++E R L  +L       E 
Sbjct: 1433 DVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEE 1492

Query: 130  AMKELSTLKKKQS----------------------LPPQKEALEANVTQDLKLPGFVEE- 166
            +++ L T K++                        L   ++ LE    + L+L   +EE 
Sbjct: 1493 SLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEV---EKLELQSALEEA 1549

Query: 167  --SCEHTDQFQLSSQMHESIREYLVKRQFSTKEDTNN---KEQGVVIDSLKLSEEMKPNL 221
              S EH +   L +Q+  +  +  ++R+ + K++      +    V+DSL+ S + +   
Sbjct: 1550 EASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRS 1609

Query: 222  DGVDLFNNGGSGNGETKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTAL 281
                L           +  ++L   N        ++ +LQ  L + Q  L         L
Sbjct: 1610 RNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDL 1669

Query: 282  EKEIERLESALSLWKWKYEELK---ESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQ 338
            ++ I  +E   +L + + EEL+   E   ++ K  +  L + ++ +Q L          +
Sbjct: 1670 KENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQK 1729

Query: 339  NSKDRVICELRAELERLQAE--NTSEWDKREI---------LEREKQG---LERENRRLK 384
               +  + +L++E+E    E  N  E  K+ I         L++E+     LER  + ++
Sbjct: 1730 KKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNME 1789

Query: 385  IQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAY---YKLNRQYQANI 441
              +K+++  LD+  +++        +  +  ++E   EL   Q       K  R+ +  I
Sbjct: 1790 QTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRI 1849

Query: 442  AELTHANNRVDQN----EAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEK 497
             ELT+      +N    +  V KL+L+V+  K+   + E++ + +L++ RK+Q  LDE +
Sbjct: 1850 KELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAE 1909

Query: 498  ERNENLETELRHLQ 511
            ER +  E+++  L+
Sbjct: 1910 ERADIAESQVNKLR 1923



 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 109/465 (23%), Positives = 206/465 (44%), Gaps = 56/465 (12%)

Query: 54   AHNFCAHSYNTNKWDICEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAER 113
            A N  AH+  + + D C+ LR +  EE +A+A ++++ +   +   A WR K+     +R
Sbjct: 1327 AKNALAHALQSARHD-CDLLREQYEEETEAKA-ELQRVLSKANSEVAQWRTKYETDAIQR 1384

Query: 114  NSAREEGRQ-LRIKLEMAMKELSTLKKK-QSLPPQKEALEANVTQDLKLPGFVEESCEHT 171
                EE ++ L  +L+ A + +  +  K  SL   K  L+ N  +DL +   VE S    
Sbjct: 1385 TEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQ-NEIEDLMVD--VERSNAAA 1441

Query: 172  DQFQLSSQMHESI-REYLVKRQFSTKE-DTNNKE-QGVVIDSLKLSEEMKPNLDGVDLFN 228
                   +  + I  E+  K + S  E +++ KE + +  +  KL    + +L+ ++ F 
Sbjct: 1442 AALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFK 1501

Query: 229  NGGSGNGETKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERL 288
                                  +N   EIS L   L E  K + +  ++R  LE E   L
Sbjct: 1502 REN-------------------KNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLEL 1542

Query: 289  ESALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQ-ELSGNIKEESKSQNSKDRVICE 347
            +SAL     + E   E +   +    +   Q   E++ +L+   +E  +++ +  RV+  
Sbjct: 1543 QSALE----EAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDS 1598

Query: 348  LRAELERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSP 407
            L+  L+   AE  S   + E+L        R  ++++  + EME  L   NR++A +Q  
Sbjct: 1599 LQTSLD---AETRS---RNEVL--------RVKKKMEGDLNEMEIQLSHANRMAAEAQK- 1643

Query: 408  DFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEE 467
              K  Q  L++   +L +   A    N   + NIA +   NN +   +AE+++LR  VE+
Sbjct: 1644 QVKSLQSLLKDTQIQLDDAVRA----NDDLKENIAIVERRNNLL---QAELEELRAVVEQ 1696

Query: 468  LKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRHLQN 512
             ++     E EL ++  +++ L         + + +E++L  LQ+
Sbjct: 1697 TERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQS 1741



 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 116/505 (22%), Positives = 211/505 (41%), Gaps = 88/505 (17%)

Query: 76   RELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREE--------GRQLRIKL 127
            ++L+E +AR  ++E+ +   ++ TA  R K  K+R++ +   EE        G    +++
Sbjct: 1108 KKLKENQARIEELEEELE--AERTA--RAKVEKLRSDLSRELEEISERLEEAGGATSVQI 1163

Query: 128  EMAMKELSTLKKK----QSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHES 183
            EM  K  +  +K     +    Q EA  A + +  K    V E  E  D  Q   Q  E 
Sbjct: 1164 EMNKKREAEFQKMRRDLEEATLQHEATAAALRK--KHADSVAELGEQIDNLQRVKQKLEK 1221

Query: 184  IREYLVKRQFSTKED--TNNKEQGVV----IDSLKLSEEMKPNLDGVDLFNNGGSGNGET 237
                  K +F  + D  T+N EQ +     ++ +  + E + N   V L     S N  T
Sbjct: 1222 -----EKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFT 1276

Query: 238  KTGLRLKAINLPLENEVTEISALQVHL-----------DEFQKILWKEREMRTALEKEIE 286
                +L+  N  L  ++ E  AL   L           ++ ++ L +E + + AL   ++
Sbjct: 1277 TQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQ 1336

Query: 287  RLESALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQEL-----SGNIKEESKSQNSK 341
                   L + +YEE  E+K     E   +L + N E+ +      +  I+   + + +K
Sbjct: 1337 SARHDCDLLREQYEEETEAKA----ELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAK 1392

Query: 342  DRVICELRAELERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEEL---LDKKN 398
             ++   L+   E ++A N     K   LE+ K  L+ E   L + V+        LDKK 
Sbjct: 1393 KKLAQRLQDAEEAVEAVNA----KCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQ 1448

Query: 399  R-----LSANSQSPDFKMSQIDLQEK-----NQELLNLQHAYYKL----------NRQYQ 438
            R     L+   Q  +   S+++  +K     + EL  L++AY +           N+  Q
Sbjct: 1449 RNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQ 1508

Query: 439  ANIAELTHANNRVDQNEAEVKKLRLRVE----ELKQGLNQKEDELDDSLNQIRKLQRSLD 494
              I++LT       +N  E++K+R ++E    EL+  L + E  L+    +I + Q   +
Sbjct: 1509 EEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFN 1568

Query: 495  EEK--------ERNENLETELRHLQ 511
            + K        E++E +E   R+ Q
Sbjct: 1569 QIKAEIERKLAEKDEEMEQAKRNHQ 1593



 Score = 57.0 bits (136), Expect = 4e-08
 Identities = 51/235 (21%), Positives = 97/235 (41%), Gaps = 30/235 (12%)

Query: 273  KEREMRTALEKEIERLESALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIK 332
            K +EM   LE E E + + L+  K K E+      K++ + ++ L +   E       +K
Sbjct: 920  KVKEMNERLEDE-EEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVK 978

Query: 333  EESKSQNSKDRVICELRAELERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEE 392
              ++     D +I +L  E + LQ  +    D  ++ E +   L +   +L+ QV ++E 
Sbjct: 979  NLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEG 1038

Query: 393  LLDKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVD 452
             L+++ ++                       ++L+ A  KL    +     +    N   
Sbjct: 1039 SLEQEKKVR----------------------MDLERAKRKLEGDLKLTQESIMDLENDKL 1076

Query: 453  QNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETEL 507
            Q E ++KK    +       NQ+  +++D      +LQ+ L E + R E LE EL
Sbjct: 1077 QLEEKLKKKEFDI-------NQQNSKIEDEQVLALQLQKKLKENQARIEELEEEL 1124



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 102/467 (21%), Positives = 198/467 (42%), Gaps = 75/467 (16%)

Query: 74   RLRE-LEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAER---NSAREEGRQL---RIK 126
            R++E LE+ +AR  ++E+ M           +   +V+AE+   N A E   QL   +I+
Sbjct: 860  RIKETLEKSEARRKELEEKM---VSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQ 916

Query: 127  LEMAMKELSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIRE 186
            LE  +KE++     + L  ++E       +  KL     E  +  D  +L+    E    
Sbjct: 917  LEAKVKEMN-----ERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVE---- 967

Query: 187  YLVKRQFSTKEDTNN-KEQGVVIDSL--KLSEEMKPNLDGVDLFNNGGSGNGETKTGLRL 243
               K + +T+    N  E+   +D +  KL++E K   +           + +    L++
Sbjct: 968  ---KEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEA----------HQQALDDLQV 1014

Query: 244  KAINLPLENEVTEISALQVHL----DEFQKILWKEREMRTALEKEIERLESALSLWKWKY 299
            +      E++V  +S  +V L    D+ +  L +E+++R  LE+   +LE  L L +   
Sbjct: 1015 E------EDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESI 1068

Query: 300  EELKESKPK-----NVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELER 354
             +L+  K +       KEFDI          + +  I++E        + + E +A +E 
Sbjct: 1069 MDLENDKLQLEEKLKKKEFDI---------NQQNSKIEDEQVLALQLQKKLKENQARIEE 1119

Query: 355  LQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQI 414
            L+ E  +E   R  +E+ +  L RE   +  +++E       +  ++   ++ +F+  + 
Sbjct: 1120 LEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREA-EFQKMRR 1178

Query: 415  DLQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQN-EAEVKKLRLRVEEL----- 468
            DL+E   +      A  K +    A + E      RV Q  E E  + +L ++++     
Sbjct: 1179 DLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNME 1238

Query: 469  -----KQGLNQKEDELDDSLNQIR----KLQRSLDEEKERNENLETE 506
                 K  L +    L+D  N+ R    + QRSL++   +   L+TE
Sbjct: 1239 QIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTE 1285



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 67/307 (21%), Positives = 127/307 (41%), Gaps = 53/307 (17%)

Query: 204 QGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLENEVTEISALQVH 263
           +G  IDS K +E++  +LD     ++     G TK   +   + L  E     +S +   
Sbjct: 734 EGQFIDSRKGTEKLLSSLD----IDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIITR 789

Query: 264 LDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELKESKPKNVKEFDILLGQHNDE 323
           +    +     + MR   +K +ER ++ L + +W           N++ F   +G  N  
Sbjct: 790 MQAQAR----GQLMRIEFKKIVERRDALLVI-QW-----------NIRAF---MGVKNWP 830

Query: 324 MQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWDKREILEREKQGLERENRRL 383
             +L   IK   KS            AE E+  A    E+       R K+ LE+   R 
Sbjct: 831 WMKLYFKIKPLLKS------------AETEKEMATMKEEFG------RIKETLEKSEARR 872

Query: 384 KIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAE 443
           K   ++M  LL +KN L    Q+    ++  D +E+  +L+       K   Q +A + E
Sbjct: 873 KELEEKMVSLLQEKNDLQLQVQAEQDNLN--DAEERCDQLI-------KNKIQLEAKVKE 923

Query: 444 LTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENL 503
           +   N R++  E    +L  +  +L+   ++ + ++DD    + K+++     + + +NL
Sbjct: 924 M---NERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNL 980

Query: 504 ETELRHL 510
             E+  L
Sbjct: 981 TEEMAGL 987


>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
            sapiens]
          Length = 1938

 Score = 76.3 bits (186), Expect = 6e-14
 Identities = 112/505 (22%), Positives = 219/505 (43%), Gaps = 80/505 (15%)

Query: 75   LRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKL------- 127
            +R+LE      A ++K  R +    A W++K  + +AE  +A++E R L  +L       
Sbjct: 1433 MRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAY 1492

Query: 128  EMAMKELSTLKK-------------KQSLPPQKEALEANVTQ--------DLKLP-GFVE 165
            E  + +L TL++             +Q     K   EA  T+        DL++    VE
Sbjct: 1493 EEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVE 1552

Query: 166  ESCEHTD------QFQLSSQMHESIREYLVKRQFSTKEDTNNKEQGVVI----------- 208
             S EH +      Q +LS    E  R+ + K +   +   N++     +           
Sbjct: 1553 GSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSR 1612

Query: 209  -DSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLENEVTEI-SALQVHLDE 266
             D+L+L ++M+ +L+ +++   G S     +T   L+ +   L++    +  AL+ + D 
Sbjct: 1613 NDALRLKKKMEGDLNEMEI-QLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDL 1671

Query: 267  FQKILWKEREMRTALEKEIERLESALSLWKWKYEELKESKPKNVKEFDILLGQHNDEM-- 324
             +++   ER     LE E+E ++ AL   + +   L E +  +  +   LL   N  +  
Sbjct: 1672 KEQLAIVERRNGLLLE-ELEEMKVALEQTE-RTRRLSEQELLDASDRVQLLHSQNTSLIN 1729

Query: 325  -------------QELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWDKREILER 371
                          E+  +I+E   ++    + I +     E L+ E     D    LER
Sbjct: 1730 TKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQ----DTSAHLER 1785

Query: 372  EKQGLERENRRLKIQVKEMEELLDK--KNRLSANSQSPDFKMSQIDLQEK-NQELLNLQH 428
             K+ LE+  + L+ ++ E E+L  K  K ++           +++D+++K   E L   H
Sbjct: 1786 MKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAH 1845

Query: 429  AYYKLNRQ--YQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQI 486
             Y +  ++  YQ   AE  H N  + + +  V KL+ +V+  K+   + E++ +  L++ 
Sbjct: 1846 KYERKVKEMTYQ---AEEDHKN--ILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRC 1900

Query: 487  RKLQRSLDEEKERNENLETELRHLQ 511
            R++Q  L+E  ER +  E+++  L+
Sbjct: 1901 RRVQHELEEAAERADIAESQVNKLR 1925



 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 88/456 (19%), Positives = 189/456 (41%), Gaps = 45/456 (9%)

Query: 77   ELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAER-NSAREEGRQLRIKLEMAMKELS 135
            ++E  K R A+ +K  R   + T       + +R ++ +S  E G Q+   L+   ++L 
Sbjct: 1164 QIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQID-NLQRVKQKLE 1222

Query: 136  TLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHT-DQFQLSSQMHESIREYLVKRQFS 194
              K+K  L  + + + +N+    K    +E +C    DQF       E        +Q  
Sbjct: 1223 --KEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDE--------QQTQ 1272

Query: 195  TKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLENEV 254
               D N ++  +   + +LS  ++     +           +     +L+ +   +E E 
Sbjct: 1273 LIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQ-----QLEELKRQMEEET 1327

Query: 255  TEISALQVHL-------DEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELKESKP 307
               +A+   L       D  ++   +E+E +  L++ + +  S ++ W+ KYE     + 
Sbjct: 1328 KAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRT 1387

Query: 308  KNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWDKRE 367
            + ++E    L Q    +QE   N +  +    S ++    L+ E+E L  +         
Sbjct: 1388 EELEEAKKKLAQR---LQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACA 1444

Query: 368  ILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQ 427
             L+++++  ++     K ++ E +  L+   + S +  +  FKM     +   +E+++  
Sbjct: 1445 TLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKM-----RNAYEEVVDQL 1499

Query: 428  HAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSL---- 483
                + N+  Q  I++LT       +N  E +K +  VE+ K  L    +E++ SL    
Sbjct: 1500 ETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEE 1559

Query: 484  NQIRKLQRSLDEEK--------ERNENLETELRHLQ 511
            ++I ++Q  L + K        E++E +E   R+ Q
Sbjct: 1560 SKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQ 1595



 Score = 59.3 bits (142), Expect = 8e-09
 Identities = 96/487 (19%), Positives = 197/487 (40%), Gaps = 53/487 (10%)

Query: 65   NKWDICEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKW-------SKVRAERNSAR 117
            N  D C  L+ R++++++    ++EK      +   N  E+        SK+  E+ S +
Sbjct: 946  NLEDKCSSLK-RDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQ 1004

Query: 118  EEGRQLRIKLEMAMKELSTLKK-KQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQL 176
            E  +Q    L++   +++ L K    L  Q + LE ++ Q+ KL   +E +    +    
Sbjct: 1005 EAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLK 1064

Query: 177  SSQMH--------ESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFN 228
             SQ          + I E L K++F   +    K     + SL+  +++K     ++   
Sbjct: 1065 MSQESIMDLENDKQQIEEKLKKKEFELSQ-LQAKIDDEQVHSLQFQKKIKELQARIEELE 1123

Query: 229  NGGSGNGETKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERL 288
                   E +  LR K I     +   E+  +   L+E       + EM    E E +++
Sbjct: 1124 E----EIEAEHTLRAK-IEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKM 1178

Query: 289  ESALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQ------------------ELSGN 330
               L     ++E    +  K   +    LG+  D +Q                  +++ N
Sbjct: 1179 RRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASN 1238

Query: 331  IKEESKSQNSKDRVICELRAELERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEM 390
            I+  SKS+++ +R    +  +   ++A++  +      L  +K  L+ +N  L  +V+E 
Sbjct: 1239 IEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEK 1298

Query: 391  EELLDK--KNRLSANSQSPDFK-MSQIDLQEKN---QELLNLQHAYYKLNRQYQANIAEL 444
            E L+ +  K++ +   Q  + K   + + + KN     L + +H    L  QY+      
Sbjct: 1299 ESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAK 1358

Query: 445  THANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLE 504
                  + +  +EV + R + E       Q+ +EL+++    +KL + L E +E  E   
Sbjct: 1359 AELQRALSKANSEVAQWRTKYE---TDAIQRTEELEEAK---KKLAQRLQEAEENTETAN 1412

Query: 505  TELRHLQ 511
            ++   L+
Sbjct: 1413 SKCASLE 1419



 Score = 43.5 bits (101), Expect = 5e-04
 Identities = 52/260 (20%), Positives = 100/260 (38%), Gaps = 35/260 (13%)

Query: 277  MRTALEKEIERLESALSL------------WKWKYEELKESKPKNVKEFDILLGQHNDEM 324
            MR   +K +ER +S   +            W W     K        E +  +    ++ 
Sbjct: 801  MRVEFKKMMERRDSIFCIQYNIRSFMNVKHWPWMNLFFKIKPLLKSAEAEKEMATMKEDF 860

Query: 325  QELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWDKREILEREKQGLERENRRLK 384
            +     +      +   +  +  L  E   LQ +  SE +     E   +GL +    L+
Sbjct: 861  ERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSKILLE 920

Query: 385  IQVKEMEELLDKK----NRLSANSQSPDFKMSQI--DLQEKNQELLNLQHAYYKLNRQYQ 438
             +VKE+ E L+++    + L A  ++ + K S +  D+ +    L  ++   +    + +
Sbjct: 921  AKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVK 980

Query: 439  ANIAELTHANNRVDQNEAEVKKLR---------LRVEE--------LKQGLNQKEDELDD 481
                E+T     + +   E K L+         L+VEE        +   L Q+ D+L+ 
Sbjct: 981  NLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEG 1040

Query: 482  SLNQIRKLQRSLDEEKERNE 501
            SL Q +KL+  L+  K + E
Sbjct: 1041 SLEQEKKLRADLERAKRKLE 1060



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 35/146 (23%), Positives = 68/146 (46%), Gaps = 12/146 (8%)

Query: 366 REILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELLN 425
           +E  ER K+ L R   R K   ++M  LL +KN L    QS    +  +D +E+ + L+ 
Sbjct: 857 KEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENL--MDAEERCEGLI- 913

Query: 426 LQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQ 485
                 K     +A + ELT      ++  +E+   +  +E+    L +  D+L+ +L +
Sbjct: 914 ------KSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTK 967

Query: 486 IRKLQRSLDEEKERNENLETELRHLQ 511
           + K + + + + +   NL  E+  L+
Sbjct: 968 VEKEKHATENKVK---NLSEEMTALE 990


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 98/451 (21%), Positives = 193/451 (42%), Gaps = 40/451 (8%)

Query: 77   ELEEV-KARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAMKELS 135
            ELE   K   A+ME  +    D   N  E     RA      E   QL    E+  +  +
Sbjct: 1501 ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLE---ELEDELQA 1557

Query: 136  TLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIREYLVKRQFST 195
            T   K  L    +AL+    +DL+      +      + QL  Q+HE          + T
Sbjct: 1558 TEDAKLRLEVNMQALKGQFERDLQ----ARDEQNEEKRRQLQRQLHE----------YET 1603

Query: 196  KEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLENEVT 255
            + +   K++ +   + K   +++ +L  ++L  +     G  +   +L+ +   +++   
Sbjct: 1604 ELEDERKQRALAAAAKK---KLEGDLKDLELQADSAI-KGREEAIKQLRKLQAQMKDFQR 1659

Query: 256  EISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELKESKPKNVKEFDI 315
            E+   +   DE      +  +   +LE ++ +L+  L+  +   ++    K +  +E   
Sbjct: 1660 ELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELAS 1719

Query: 316  LLGQHN---DEMQELSGNI--------KEESKSQNSKDRVICELRAELERLQAENTSEWD 364
             L   N   DE + L   I        +E+   +   DRV  +   + E+L  E  +E  
Sbjct: 1720 SLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR-KATQQAEQLSNELATERS 1778

Query: 365  KREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELL 424
              +  E  +Q LER+N+ L+ ++ EME  +  K++  +   + + K++Q++ ++  QE  
Sbjct: 1779 TAQKNESARQQLERQNKELRSKLHEMEGAV--KSKFKSTIAALEAKIAQLE-EQVEQEAR 1835

Query: 425  NLQHAYYKL---NRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDD 481
              Q A   L   +++ +  + ++       +Q + + +K   RV++LK+ L + E+E   
Sbjct: 1836 EKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQR 1895

Query: 482  SLNQIRKLQRSLDEEKERNENLETELRHLQN 512
                 RKLQR LDE  E NE +  E+  L++
Sbjct: 1896 INANRRKLQRELDEATESNEAMGREVNALKS 1926



 Score = 70.5 bits (171), Expect = 4e-12
 Identities = 103/466 (22%), Positives = 195/466 (41%), Gaps = 77/466 (16%)

Query: 76   RELEEVKARAAQMEKTMRWWSDCTANWRE---KWSKVRAERNSARE----------EGRQ 122
            R+ EE++A+  +++KT           +E   K S++  E+N  +E          E  +
Sbjct: 849  RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE 908

Query: 123  LRIKLEMAMKEL--------STLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQF 174
            +R++L    +EL        + L++++    Q +A    + Q +     +EE  E  +  
Sbjct: 909  MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQML---DLEEQLEEEEAA 965

Query: 175  QLSSQMHESIREYLVKR---QFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGV-DLFNNG 230
            +   Q+ +   E  +K+   +    +D NNK          LS+E K   + + DL  N 
Sbjct: 966  RQKLQLEKVTAEAKIKKLEDEILVMDDQNNK----------LSKERKLLEERISDLTTNL 1015

Query: 231  GSGNGETKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLES 290
                 + K   +LK          + IS L+V L        KE + R    +E+E+L+ 
Sbjct: 1016 AEEEEKAKNLTKLK------NKHESMISELEVRLK-------KEEKSR----QELEKLKR 1058

Query: 291  ALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRA 350
             L      + E        + E  + L +  +E+Q     + +E   +N+  + I EL  
Sbjct: 1059 KLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEG 1118

Query: 351  ELERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFK 410
             +  LQ +  SE   R   E++K+ L  E   LK    E+E+ LD     +A  Q    K
Sbjct: 1119 HISDLQEDLDSERAARNKAEKQKRDLGEELEALK---TELEDTLDS----TATQQELRAK 1171

Query: 411  MSQIDLQEKNQELLNLQHAYYKLNRQYQANIAEL----THANNRVDQNEAEVKKLRLRVE 466
                    + QE+  L+ A  +  R ++A + E+      A   + +   + K+ +  ++
Sbjct: 1172 --------REQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD 1223

Query: 467  ELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRHLQN 512
            + KQ L   E E  D   ++R L ++  E + + + LE +++ LQ+
Sbjct: 1224 KNKQTL---EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQS 1266



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 128/564 (22%), Positives = 226/564 (40%), Gaps = 132/564 (23%)

Query: 72   ELRLREL-EEVKARAAQMEKTMRWWSDCTANWREKWSKVRAE----RNSAREEGR----- 121
            E + R+L EE++A   ++E T+    D TA  +E  +K   E    + +  EE R     
Sbjct: 1138 EKQKRDLGEELEALKTELEDTL----DSTATQQELRAKREQEVTVLKKALDEETRSHEAQ 1193

Query: 122  --QLRIKLEMAMKELSTL-----KKKQSLPPQKEALE---ANVTQDLKLPGFVEESCEHT 171
              ++R K   A++EL+       + K +L   K+ LE   A++  +L++ G  ++  EH 
Sbjct: 1194 VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHK 1253

Query: 172  DQFQLSSQMHE-------------SIREYLVKRQFSTKEDTN--NKEQGVVIDSLKLSEE 216
             + +L +Q+ E              + + + K Q   +  T   N+ +G  I   K    
Sbjct: 1254 KK-KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1312

Query: 217  MKPNL-DGVDLFNNGGSGNGETKTGLR-LKAINLPLENEVTE-----------ISALQVH 263
            +   L D  +L            T LR L+     L++++ E           IS L + 
Sbjct: 1313 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1372

Query: 264  LDEFQKILWKEREMRTALE-------KEIERLESALSLWKWKYEELKESKPKNVKEFDIL 316
            L + +K L        ALE       KEIE L          Y++L+++K +  +E D L
Sbjct: 1373 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 1432

Query: 317  LGQHNDEMQELSGNIKEE--------------SKSQNSKDRVICELR-----------AE 351
            +   +++ Q +S   K++              SK  + +DR   E R           A 
Sbjct: 1433 VVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL 1492

Query: 352  LERLQA----ENTSEWDKREI----------------LEREKQGLERENRRLKIQVKEME 391
             E L+A    E T++  K E+                LE+ K+ LE +   +K Q++E+E
Sbjct: 1493 EEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELE 1552

Query: 392  ELL----DKKNRLSANSQS------PDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANI 441
            + L    D K RL  N Q+       D +      +EK ++L    H Y       +   
Sbjct: 1553 DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR 1612

Query: 442  AELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLD------- 494
            A    A  ++   E ++K L L+ +   +G  +   +L     Q++  QR L+       
Sbjct: 1613 ALAAAAKKKL---EGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD 1669

Query: 495  -------EEKERNENLETELRHLQ 511
                   E +++ ++LE +L  LQ
Sbjct: 1670 EIFATAKENEKKAKSLEADLMQLQ 1693



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 102/464 (21%), Positives = 188/464 (40%), Gaps = 77/464 (16%)

Query: 72   ELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAM 131
            EL +R  +E K+R  ++EK  R      +++ E+ + ++A+            +K+++A 
Sbjct: 1038 ELEVRLKKEEKSRQ-ELEKLKRKLEGDASDFHEQIADLQAQI---------AELKMQLA- 1086

Query: 132  KELSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIREYLVKR 191
                  KK++ L      L+  + Q       + E   H    Q       + R      
Sbjct: 1087 ------KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARN----- 1135

Query: 192  QFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLE 251
                K +   ++ G  +++LK   E++  LD              T+  LR K      E
Sbjct: 1136 ----KAEKQKRDLGEELEALKT--ELEDTLDST-----------ATQQELRAKR-----E 1173

Query: 252  NEVTEISALQVHLDEFQKILWKE-REMRTALEKEIERLESALSLWKWKYEELKESKPKNV 310
             EVT    L+  LDE  +    + +EMR    + +E L   L  +K     L ++K    
Sbjct: 1174 QEVT---VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE 1230

Query: 311  KEFDIL------LGQHNDEMQ----ELSGNIKEESKSQNSKDRVICELRAELERLQAENT 360
            KE   L      LGQ   E++    +L   ++E     +  +R   EL  ++ +LQ E  
Sbjct: 1231 KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVE 1290

Query: 361  SEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQID----- 415
            S        E +   L ++   L  Q+++ +ELL ++ R   N  +   K+ Q++     
Sbjct: 1291 SVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVST---KLRQLEEERNS 1347

Query: 416  ----LQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQG 471
                L E+ +   NL+     LN Q   +  +L    + V+  E   K+ +  +E L Q 
Sbjct: 1348 LQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQ 1407

Query: 472  LNQKE---DELDDSLNQIRK----LQRSLDEEKERNENLETELR 508
              +K    D+L+ + N++++    L   LD +++   NLE + R
Sbjct: 1408 YEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQR 1451



 Score = 38.5 bits (88), Expect = 0.015
 Identities = 63/335 (18%), Positives = 138/335 (41%), Gaps = 67/335 (20%)

Query: 76   RELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAMKEL- 134
            RELE+ +A   ++  T +       +      +++ +  +A    +Q  ++ E   +EL 
Sbjct: 1659 RELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1718

Query: 135  STLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEH--------TDQFQLSSQMHESIRE 186
            S+L  + +L  +K  LEA + Q       +EE  E         +D+ + ++Q  E +  
Sbjct: 1719 SSLSGRNALQDEKRRLEARIAQ-------LEEELEEEQGNMEAMSDRVRKATQQAEQL-- 1769

Query: 187  YLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAI 246
                 + +T+  T  K +       + ++E++  L  ++         G  K+  +    
Sbjct: 1770 ---SNELATERSTAQKNESARQQLERQNKELRSKLHEME---------GAVKSKFK---- 1813

Query: 247  NLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELKESK 306
                    + I+AL+  + + ++           +E+E    ++A    K K ++LKE  
Sbjct: 1814 --------STIAALEAKIAQLEE----------QVEQEAREKQAATKSLKQKDKKLKE-- 1853

Query: 307  PKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWDKR 366
                     +L Q  DE ++++   KE+++  N++   + +L+ +LE  + E+      R
Sbjct: 1854 ---------ILLQVEDE-RKMAEQYKEQAEKGNAR---VKQLKRQLEEAEEESQRINANR 1900

Query: 367  EILEREKQGLERENRRLKIQVKEMEELLDKKNRLS 401
              L+RE       N  +  +V  ++  L + N  S
Sbjct: 1901 RKLQRELDEATESNEAMGREVNALKSKLRRGNETS 1935


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 98/451 (21%), Positives = 193/451 (42%), Gaps = 40/451 (8%)

Query: 77   ELEEV-KARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAMKELS 135
            ELE   K   A+ME  +    D   N  E     RA      E   QL    E+  +  +
Sbjct: 1508 ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLE---ELEDELQA 1564

Query: 136  TLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIREYLVKRQFST 195
            T   K  L    +AL+    +DL+      +      + QL  Q+HE          + T
Sbjct: 1565 TEDAKLRLEVNMQALKGQFERDLQ----ARDEQNEEKRRQLQRQLHE----------YET 1610

Query: 196  KEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLENEVT 255
            + +   K++ +   + K   +++ +L  ++L  +     G  +   +L+ +   +++   
Sbjct: 1611 ELEDERKQRALAAAAKK---KLEGDLKDLELQADSAI-KGREEAIKQLRKLQAQMKDFQR 1666

Query: 256  EISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELKESKPKNVKEFDI 315
            E+   +   DE      +  +   +LE ++ +L+  L+  +   ++    K +  +E   
Sbjct: 1667 ELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELAS 1726

Query: 316  LLGQHN---DEMQELSGNI--------KEESKSQNSKDRVICELRAELERLQAENTSEWD 364
             L   N   DE + L   I        +E+   +   DRV  +   + E+L  E  +E  
Sbjct: 1727 SLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR-KATQQAEQLSNELATERS 1785

Query: 365  KREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELL 424
              +  E  +Q LER+N+ L+ ++ EME  +  K++  +   + + K++Q++ ++  QE  
Sbjct: 1786 TAQKNESARQQLERQNKELRSKLHEMEGAV--KSKFKSTIAALEAKIAQLE-EQVEQEAR 1842

Query: 425  NLQHAYYKL---NRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDD 481
              Q A   L   +++ +  + ++       +Q + + +K   RV++LK+ L + E+E   
Sbjct: 1843 EKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQR 1902

Query: 482  SLNQIRKLQRSLDEEKERNENLETELRHLQN 512
                 RKLQR LDE  E NE +  E+  L++
Sbjct: 1903 INANRRKLQRELDEATESNEAMGREVNALKS 1933



 Score = 70.5 bits (171), Expect = 4e-12
 Identities = 103/466 (22%), Positives = 195/466 (41%), Gaps = 77/466 (16%)

Query: 76   RELEEVKARAAQMEKTMRWWSDCTANWRE---KWSKVRAERNSARE----------EGRQ 122
            R+ EE++A+  +++KT           +E   K S++  E+N  +E          E  +
Sbjct: 856  RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE 915

Query: 123  LRIKLEMAMKEL--------STLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQF 174
            +R++L    +EL        + L++++    Q +A    + Q +     +EE  E  +  
Sbjct: 916  MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQML---DLEEQLEEEEAA 972

Query: 175  QLSSQMHESIREYLVKR---QFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGV-DLFNNG 230
            +   Q+ +   E  +K+   +    +D NNK          LS+E K   + + DL  N 
Sbjct: 973  RQKLQLEKVTAEAKIKKLEDEILVMDDQNNK----------LSKERKLLEERISDLTTNL 1022

Query: 231  GSGNGETKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLES 290
                 + K   +LK          + IS L+V L        KE + R    +E+E+L+ 
Sbjct: 1023 AEEEEKAKNLTKLK------NKHESMISELEVRLK-------KEEKSR----QELEKLKR 1065

Query: 291  ALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRA 350
             L      + E        + E  + L +  +E+Q     + +E   +N+  + I EL  
Sbjct: 1066 KLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEG 1125

Query: 351  ELERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFK 410
             +  LQ +  SE   R   E++K+ L  E   LK    E+E+ LD     +A  Q    K
Sbjct: 1126 HISDLQEDLDSERAARNKAEKQKRDLGEELEALK---TELEDTLDS----TATQQELRAK 1178

Query: 411  MSQIDLQEKNQELLNLQHAYYKLNRQYQANIAEL----THANNRVDQNEAEVKKLRLRVE 466
                    + QE+  L+ A  +  R ++A + E+      A   + +   + K+ +  ++
Sbjct: 1179 --------REQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD 1230

Query: 467  ELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRHLQN 512
            + KQ L   E E  D   ++R L ++  E + + + LE +++ LQ+
Sbjct: 1231 KNKQTL---EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQS 1273



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 128/564 (22%), Positives = 226/564 (40%), Gaps = 132/564 (23%)

Query: 72   ELRLREL-EEVKARAAQMEKTMRWWSDCTANWREKWSKVRAE----RNSAREEGR----- 121
            E + R+L EE++A   ++E T+    D TA  +E  +K   E    + +  EE R     
Sbjct: 1145 EKQKRDLGEELEALKTELEDTL----DSTATQQELRAKREQEVTVLKKALDEETRSHEAQ 1200

Query: 122  --QLRIKLEMAMKELSTL-----KKKQSLPPQKEALE---ANVTQDLKLPGFVEESCEHT 171
              ++R K   A++EL+       + K +L   K+ LE   A++  +L++ G  ++  EH 
Sbjct: 1201 VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHK 1260

Query: 172  DQFQLSSQMHE-------------SIREYLVKRQFSTKEDTN--NKEQGVVIDSLKLSEE 216
             + +L +Q+ E              + + + K Q   +  T   N+ +G  I   K    
Sbjct: 1261 KK-KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1319

Query: 217  MKPNL-DGVDLFNNGGSGNGETKTGLR-LKAINLPLENEVTE-----------ISALQVH 263
            +   L D  +L            T LR L+     L++++ E           IS L + 
Sbjct: 1320 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1379

Query: 264  LDEFQKILWKEREMRTALE-------KEIERLESALSLWKWKYEELKESKPKNVKEFDIL 316
            L + +K L        ALE       KEIE L          Y++L+++K +  +E D L
Sbjct: 1380 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 1439

Query: 317  LGQHNDEMQELSGNIKEE--------------SKSQNSKDRVICELR-----------AE 351
            +   +++ Q +S   K++              SK  + +DR   E R           A 
Sbjct: 1440 VVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL 1499

Query: 352  LERLQA----ENTSEWDKREI----------------LEREKQGLERENRRLKIQVKEME 391
             E L+A    E T++  K E+                LE+ K+ LE +   +K Q++E+E
Sbjct: 1500 EEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELE 1559

Query: 392  ELL----DKKNRLSANSQS------PDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANI 441
            + L    D K RL  N Q+       D +      +EK ++L    H Y       +   
Sbjct: 1560 DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR 1619

Query: 442  AELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLD------- 494
            A    A  ++   E ++K L L+ +   +G  +   +L     Q++  QR L+       
Sbjct: 1620 ALAAAAKKKL---EGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD 1676

Query: 495  -------EEKERNENLETELRHLQ 511
                   E +++ ++LE +L  LQ
Sbjct: 1677 EIFATAKENEKKAKSLEADLMQLQ 1700



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 102/464 (21%), Positives = 188/464 (40%), Gaps = 77/464 (16%)

Query: 72   ELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAM 131
            EL +R  +E K+R  ++EK  R      +++ E+ + ++A+            +K+++A 
Sbjct: 1045 ELEVRLKKEEKSRQ-ELEKLKRKLEGDASDFHEQIADLQAQI---------AELKMQLA- 1093

Query: 132  KELSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIREYLVKR 191
                  KK++ L      L+  + Q       + E   H    Q       + R      
Sbjct: 1094 ------KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARN----- 1142

Query: 192  QFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLE 251
                K +   ++ G  +++LK   E++  LD              T+  LR K      E
Sbjct: 1143 ----KAEKQKRDLGEELEALKT--ELEDTLDST-----------ATQQELRAKR-----E 1180

Query: 252  NEVTEISALQVHLDEFQKILWKE-REMRTALEKEIERLESALSLWKWKYEELKESKPKNV 310
             EVT    L+  LDE  +    + +EMR    + +E L   L  +K     L ++K    
Sbjct: 1181 QEVT---VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE 1237

Query: 311  KEFDIL------LGQHNDEMQ----ELSGNIKEESKSQNSKDRVICELRAELERLQAENT 360
            KE   L      LGQ   E++    +L   ++E     +  +R   EL  ++ +LQ E  
Sbjct: 1238 KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVE 1297

Query: 361  SEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQID----- 415
            S        E +   L ++   L  Q+++ +ELL ++ R   N  +   K+ Q++     
Sbjct: 1298 SVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVST---KLRQLEEERNS 1354

Query: 416  ----LQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQG 471
                L E+ +   NL+     LN Q   +  +L    + V+  E   K+ +  +E L Q 
Sbjct: 1355 LQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQ 1414

Query: 472  LNQKE---DELDDSLNQIRK----LQRSLDEEKERNENLETELR 508
              +K    D+L+ + N++++    L   LD +++   NLE + R
Sbjct: 1415 YEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQR 1458



 Score = 38.5 bits (88), Expect = 0.015
 Identities = 63/335 (18%), Positives = 138/335 (41%), Gaps = 67/335 (20%)

Query: 76   RELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAMKEL- 134
            RELE+ +A   ++  T +       +      +++ +  +A    +Q  ++ E   +EL 
Sbjct: 1666 RELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1725

Query: 135  STLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEH--------TDQFQLSSQMHESIRE 186
            S+L  + +L  +K  LEA + Q       +EE  E         +D+ + ++Q  E +  
Sbjct: 1726 SSLSGRNALQDEKRRLEARIAQ-------LEEELEEEQGNMEAMSDRVRKATQQAEQL-- 1776

Query: 187  YLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAI 246
                 + +T+  T  K +       + ++E++  L  ++         G  K+  +    
Sbjct: 1777 ---SNELATERSTAQKNESARQQLERQNKELRSKLHEME---------GAVKSKFK---- 1820

Query: 247  NLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELKESK 306
                    + I+AL+  + + ++           +E+E    ++A    K K ++LKE  
Sbjct: 1821 --------STIAALEAKIAQLEE----------QVEQEAREKQAATKSLKQKDKKLKE-- 1860

Query: 307  PKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWDKR 366
                     +L Q  DE ++++   KE+++  N++   + +L+ +LE  + E+      R
Sbjct: 1861 ---------ILLQVEDE-RKMAEQYKEQAEKGNAR---VKQLKRQLEEAEEESQRINANR 1907

Query: 367  EILEREKQGLERENRRLKIQVKEMEELLDKKNRLS 401
              L+RE       N  +  +V  ++  L + N  S
Sbjct: 1908 RKLQRELDEATESNEAMGREVNALKSKLRRGNETS 1942


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 98/451 (21%), Positives = 193/451 (42%), Gaps = 40/451 (8%)

Query: 77   ELEEV-KARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAMKELS 135
            ELE   K   A+ME  +    D   N  E     RA      E   QL    E+  +  +
Sbjct: 1508 ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLE---ELEDELQA 1564

Query: 136  TLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIREYLVKRQFST 195
            T   K  L    +AL+    +DL+      +      + QL  Q+HE          + T
Sbjct: 1565 TEDAKLRLEVNMQALKGQFERDLQ----ARDEQNEEKRRQLQRQLHE----------YET 1610

Query: 196  KEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLENEVT 255
            + +   K++ +   + K   +++ +L  ++L  +     G  +   +L+ +   +++   
Sbjct: 1611 ELEDERKQRALAAAAKK---KLEGDLKDLELQADSAI-KGREEAIKQLRKLQAQMKDFQR 1666

Query: 256  EISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELKESKPKNVKEFDI 315
            E+   +   DE      +  +   +LE ++ +L+  L+  +   ++    K +  +E   
Sbjct: 1667 ELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELAS 1726

Query: 316  LLGQHN---DEMQELSGNI--------KEESKSQNSKDRVICELRAELERLQAENTSEWD 364
             L   N   DE + L   I        +E+   +   DRV  +   + E+L  E  +E  
Sbjct: 1727 SLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR-KATQQAEQLSNELATERS 1785

Query: 365  KREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELL 424
              +  E  +Q LER+N+ L+ ++ EME  +  K++  +   + + K++Q++ ++  QE  
Sbjct: 1786 TAQKNESARQQLERQNKELRSKLHEMEGAV--KSKFKSTIAALEAKIAQLE-EQVEQEAR 1842

Query: 425  NLQHAYYKL---NRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDD 481
              Q A   L   +++ +  + ++       +Q + + +K   RV++LK+ L + E+E   
Sbjct: 1843 EKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQR 1902

Query: 482  SLNQIRKLQRSLDEEKERNENLETELRHLQN 512
                 RKLQR LDE  E NE +  E+  L++
Sbjct: 1903 INANRRKLQRELDEATESNEAMGREVNALKS 1933



 Score = 70.5 bits (171), Expect = 4e-12
 Identities = 103/466 (22%), Positives = 195/466 (41%), Gaps = 77/466 (16%)

Query: 76   RELEEVKARAAQMEKTMRWWSDCTANWRE---KWSKVRAERNSARE----------EGRQ 122
            R+ EE++A+  +++KT           +E   K S++  E+N  +E          E  +
Sbjct: 856  RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE 915

Query: 123  LRIKLEMAMKEL--------STLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQF 174
            +R++L    +EL        + L++++    Q +A    + Q +     +EE  E  +  
Sbjct: 916  MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQML---DLEEQLEEEEAA 972

Query: 175  QLSSQMHESIREYLVKR---QFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGV-DLFNNG 230
            +   Q+ +   E  +K+   +    +D NNK          LS+E K   + + DL  N 
Sbjct: 973  RQKLQLEKVTAEAKIKKLEDEILVMDDQNNK----------LSKERKLLEERISDLTTNL 1022

Query: 231  GSGNGETKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLES 290
                 + K   +LK          + IS L+V L        KE + R    +E+E+L+ 
Sbjct: 1023 AEEEEKAKNLTKLK------NKHESMISELEVRLK-------KEEKSR----QELEKLKR 1065

Query: 291  ALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRA 350
             L      + E        + E  + L +  +E+Q     + +E   +N+  + I EL  
Sbjct: 1066 KLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEG 1125

Query: 351  ELERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFK 410
             +  LQ +  SE   R   E++K+ L  E   LK    E+E+ LD     +A  Q    K
Sbjct: 1126 HISDLQEDLDSERAARNKAEKQKRDLGEELEALK---TELEDTLDS----TATQQELRAK 1178

Query: 411  MSQIDLQEKNQELLNLQHAYYKLNRQYQANIAEL----THANNRVDQNEAEVKKLRLRVE 466
                    + QE+  L+ A  +  R ++A + E+      A   + +   + K+ +  ++
Sbjct: 1179 --------REQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD 1230

Query: 467  ELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRHLQN 512
            + KQ L   E E  D   ++R L ++  E + + + LE +++ LQ+
Sbjct: 1231 KNKQTL---EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQS 1273



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 128/564 (22%), Positives = 226/564 (40%), Gaps = 132/564 (23%)

Query: 72   ELRLREL-EEVKARAAQMEKTMRWWSDCTANWREKWSKVRAE----RNSAREEGR----- 121
            E + R+L EE++A   ++E T+    D TA  +E  +K   E    + +  EE R     
Sbjct: 1145 EKQKRDLGEELEALKTELEDTL----DSTATQQELRAKREQEVTVLKKALDEETRSHEAQ 1200

Query: 122  --QLRIKLEMAMKELSTL-----KKKQSLPPQKEALE---ANVTQDLKLPGFVEESCEHT 171
              ++R K   A++EL+       + K +L   K+ LE   A++  +L++ G  ++  EH 
Sbjct: 1201 VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHK 1260

Query: 172  DQFQLSSQMHE-------------SIREYLVKRQFSTKEDTN--NKEQGVVIDSLKLSEE 216
             + +L +Q+ E              + + + K Q   +  T   N+ +G  I   K    
Sbjct: 1261 KK-KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1319

Query: 217  MKPNL-DGVDLFNNGGSGNGETKTGLR-LKAINLPLENEVTE-----------ISALQVH 263
            +   L D  +L            T LR L+     L++++ E           IS L + 
Sbjct: 1320 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1379

Query: 264  LDEFQKILWKEREMRTALE-------KEIERLESALSLWKWKYEELKESKPKNVKEFDIL 316
            L + +K L        ALE       KEIE L          Y++L+++K +  +E D L
Sbjct: 1380 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 1439

Query: 317  LGQHNDEMQELSGNIKEE--------------SKSQNSKDRVICELR-----------AE 351
            +   +++ Q +S   K++              SK  + +DR   E R           A 
Sbjct: 1440 VVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL 1499

Query: 352  LERLQA----ENTSEWDKREI----------------LEREKQGLERENRRLKIQVKEME 391
             E L+A    E T++  K E+                LE+ K+ LE +   +K Q++E+E
Sbjct: 1500 EEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELE 1559

Query: 392  ELL----DKKNRLSANSQS------PDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANI 441
            + L    D K RL  N Q+       D +      +EK ++L    H Y       +   
Sbjct: 1560 DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR 1619

Query: 442  AELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLD------- 494
            A    A  ++   E ++K L L+ +   +G  +   +L     Q++  QR L+       
Sbjct: 1620 ALAAAAKKKL---EGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD 1676

Query: 495  -------EEKERNENLETELRHLQ 511
                   E +++ ++LE +L  LQ
Sbjct: 1677 EIFATAKENEKKAKSLEADLMQLQ 1700



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 102/464 (21%), Positives = 188/464 (40%), Gaps = 77/464 (16%)

Query: 72   ELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAM 131
            EL +R  +E K+R  ++EK  R      +++ E+ + ++A+            +K+++A 
Sbjct: 1045 ELEVRLKKEEKSRQ-ELEKLKRKLEGDASDFHEQIADLQAQI---------AELKMQLA- 1093

Query: 132  KELSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIREYLVKR 191
                  KK++ L      L+  + Q       + E   H    Q       + R      
Sbjct: 1094 ------KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARN----- 1142

Query: 192  QFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLE 251
                K +   ++ G  +++LK   E++  LD              T+  LR K      E
Sbjct: 1143 ----KAEKQKRDLGEELEALKT--ELEDTLDST-----------ATQQELRAKR-----E 1180

Query: 252  NEVTEISALQVHLDEFQKILWKE-REMRTALEKEIERLESALSLWKWKYEELKESKPKNV 310
             EVT    L+  LDE  +    + +EMR    + +E L   L  +K     L ++K    
Sbjct: 1181 QEVT---VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE 1237

Query: 311  KEFDIL------LGQHNDEMQ----ELSGNIKEESKSQNSKDRVICELRAELERLQAENT 360
            KE   L      LGQ   E++    +L   ++E     +  +R   EL  ++ +LQ E  
Sbjct: 1238 KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVE 1297

Query: 361  SEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQID----- 415
            S        E +   L ++   L  Q+++ +ELL ++ R   N  +   K+ Q++     
Sbjct: 1298 SVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVST---KLRQLEEERNS 1354

Query: 416  ----LQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQG 471
                L E+ +   NL+     LN Q   +  +L    + V+  E   K+ +  +E L Q 
Sbjct: 1355 LQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQ 1414

Query: 472  LNQKE---DELDDSLNQIRK----LQRSLDEEKERNENLETELR 508
              +K    D+L+ + N++++    L   LD +++   NLE + R
Sbjct: 1415 YEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQR 1458


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 98/451 (21%), Positives = 193/451 (42%), Gaps = 40/451 (8%)

Query: 77   ELEEV-KARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAMKELS 135
            ELE   K   A+ME  +    D   N  E     RA      E   QL    E+  +  +
Sbjct: 1501 ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLE---ELEDELQA 1557

Query: 136  TLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIREYLVKRQFST 195
            T   K  L    +AL+    +DL+      +      + QL  Q+HE          + T
Sbjct: 1558 TEDAKLRLEVNMQALKGQFERDLQ----ARDEQNEEKRRQLQRQLHE----------YET 1603

Query: 196  KEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLENEVT 255
            + +   K++ +   + K   +++ +L  ++L  +     G  +   +L+ +   +++   
Sbjct: 1604 ELEDERKQRALAAAAKK---KLEGDLKDLELQADSAI-KGREEAIKQLRKLQAQMKDFQR 1659

Query: 256  EISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELKESKPKNVKEFDI 315
            E+   +   DE      +  +   +LE ++ +L+  L+  +   ++    K +  +E   
Sbjct: 1660 ELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELAS 1719

Query: 316  LLGQHN---DEMQELSGNI--------KEESKSQNSKDRVICELRAELERLQAENTSEWD 364
             L   N   DE + L   I        +E+   +   DRV  +   + E+L  E  +E  
Sbjct: 1720 SLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR-KATQQAEQLSNELATERS 1778

Query: 365  KREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELL 424
              +  E  +Q LER+N+ L+ ++ EME  +  K++  +   + + K++Q++ ++  QE  
Sbjct: 1779 TAQKNESARQQLERQNKELRSKLHEMEGAV--KSKFKSTIAALEAKIAQLE-EQVEQEAR 1835

Query: 425  NLQHAYYKL---NRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDD 481
              Q A   L   +++ +  + ++       +Q + + +K   RV++LK+ L + E+E   
Sbjct: 1836 EKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQR 1895

Query: 482  SLNQIRKLQRSLDEEKERNENLETELRHLQN 512
                 RKLQR LDE  E NE +  E+  L++
Sbjct: 1896 INANRRKLQRELDEATESNEAMGREVNALKS 1926



 Score = 70.5 bits (171), Expect = 4e-12
 Identities = 103/466 (22%), Positives = 195/466 (41%), Gaps = 77/466 (16%)

Query: 76   RELEEVKARAAQMEKTMRWWSDCTANWRE---KWSKVRAERNSARE----------EGRQ 122
            R+ EE++A+  +++KT           +E   K S++  E+N  +E          E  +
Sbjct: 849  RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE 908

Query: 123  LRIKLEMAMKEL--------STLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQF 174
            +R++L    +EL        + L++++    Q +A    + Q +     +EE  E  +  
Sbjct: 909  MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQML---DLEEQLEEEEAA 965

Query: 175  QLSSQMHESIREYLVKR---QFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGV-DLFNNG 230
            +   Q+ +   E  +K+   +    +D NNK          LS+E K   + + DL  N 
Sbjct: 966  RQKLQLEKVTAEAKIKKLEDEILVMDDQNNK----------LSKERKLLEERISDLTTNL 1015

Query: 231  GSGNGETKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLES 290
                 + K   +LK          + IS L+V L        KE + R    +E+E+L+ 
Sbjct: 1016 AEEEEKAKNLTKLK------NKHESMISELEVRLK-------KEEKSR----QELEKLKR 1058

Query: 291  ALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRA 350
             L      + E        + E  + L +  +E+Q     + +E   +N+  + I EL  
Sbjct: 1059 KLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEG 1118

Query: 351  ELERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFK 410
             +  LQ +  SE   R   E++K+ L  E   LK    E+E+ LD     +A  Q    K
Sbjct: 1119 HISDLQEDLDSERAARNKAEKQKRDLGEELEALK---TELEDTLDS----TATQQELRAK 1171

Query: 411  MSQIDLQEKNQELLNLQHAYYKLNRQYQANIAEL----THANNRVDQNEAEVKKLRLRVE 466
                    + QE+  L+ A  +  R ++A + E+      A   + +   + K+ +  ++
Sbjct: 1172 --------REQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD 1223

Query: 467  ELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRHLQN 512
            + KQ L   E E  D   ++R L ++  E + + + LE +++ LQ+
Sbjct: 1224 KNKQTL---EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQS 1266



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 128/564 (22%), Positives = 226/564 (40%), Gaps = 132/564 (23%)

Query: 72   ELRLREL-EEVKARAAQMEKTMRWWSDCTANWREKWSKVRAE----RNSAREEGR----- 121
            E + R+L EE++A   ++E T+    D TA  +E  +K   E    + +  EE R     
Sbjct: 1138 EKQKRDLGEELEALKTELEDTL----DSTATQQELRAKREQEVTVLKKALDEETRSHEAQ 1193

Query: 122  --QLRIKLEMAMKELSTL-----KKKQSLPPQKEALE---ANVTQDLKLPGFVEESCEHT 171
              ++R K   A++EL+       + K +L   K+ LE   A++  +L++ G  ++  EH 
Sbjct: 1194 VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHK 1253

Query: 172  DQFQLSSQMHE-------------SIREYLVKRQFSTKEDTN--NKEQGVVIDSLKLSEE 216
             + +L +Q+ E              + + + K Q   +  T   N+ +G  I   K    
Sbjct: 1254 KK-KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1312

Query: 217  MKPNL-DGVDLFNNGGSGNGETKTGLR-LKAINLPLENEVTE-----------ISALQVH 263
            +   L D  +L            T LR L+     L++++ E           IS L + 
Sbjct: 1313 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1372

Query: 264  LDEFQKILWKEREMRTALE-------KEIERLESALSLWKWKYEELKESKPKNVKEFDIL 316
            L + +K L        ALE       KEIE L          Y++L+++K +  +E D L
Sbjct: 1373 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 1432

Query: 317  LGQHNDEMQELSGNIKEE--------------SKSQNSKDRVICELR-----------AE 351
            +   +++ Q +S   K++              SK  + +DR   E R           A 
Sbjct: 1433 VVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL 1492

Query: 352  LERLQA----ENTSEWDKREI----------------LEREKQGLERENRRLKIQVKEME 391
             E L+A    E T++  K E+                LE+ K+ LE +   +K Q++E+E
Sbjct: 1493 EEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELE 1552

Query: 392  ELL----DKKNRLSANSQS------PDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANI 441
            + L    D K RL  N Q+       D +      +EK ++L    H Y       +   
Sbjct: 1553 DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR 1612

Query: 442  AELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLD------- 494
            A    A  ++   E ++K L L+ +   +G  +   +L     Q++  QR L+       
Sbjct: 1613 ALAAAAKKKL---EGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD 1669

Query: 495  -------EEKERNENLETELRHLQ 511
                   E +++ ++LE +L  LQ
Sbjct: 1670 EIFATAKENEKKAKSLEADLMQLQ 1693



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 102/464 (21%), Positives = 188/464 (40%), Gaps = 77/464 (16%)

Query: 72   ELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAM 131
            EL +R  +E K+R  ++EK  R      +++ E+ + ++A+            +K+++A 
Sbjct: 1038 ELEVRLKKEEKSRQ-ELEKLKRKLEGDASDFHEQIADLQAQI---------AELKMQLA- 1086

Query: 132  KELSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIREYLVKR 191
                  KK++ L      L+  + Q       + E   H    Q       + R      
Sbjct: 1087 ------KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARN----- 1135

Query: 192  QFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLE 251
                K +   ++ G  +++LK   E++  LD              T+  LR K      E
Sbjct: 1136 ----KAEKQKRDLGEELEALKT--ELEDTLDST-----------ATQQELRAKR-----E 1173

Query: 252  NEVTEISALQVHLDEFQKILWKE-REMRTALEKEIERLESALSLWKWKYEELKESKPKNV 310
             EVT    L+  LDE  +    + +EMR    + +E L   L  +K     L ++K    
Sbjct: 1174 QEVT---VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE 1230

Query: 311  KEFDIL------LGQHNDEMQ----ELSGNIKEESKSQNSKDRVICELRAELERLQAENT 360
            KE   L      LGQ   E++    +L   ++E     +  +R   EL  ++ +LQ E  
Sbjct: 1231 KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVE 1290

Query: 361  SEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQID----- 415
            S        E +   L ++   L  Q+++ +ELL ++ R   N  +   K+ Q++     
Sbjct: 1291 SVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVST---KLRQLEEERNS 1347

Query: 416  ----LQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQG 471
                L E+ +   NL+     LN Q   +  +L    + V+  E   K+ +  +E L Q 
Sbjct: 1348 LQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQ 1407

Query: 472  LNQKE---DELDDSLNQIRK----LQRSLDEEKERNENLETELR 508
              +K    D+L+ + N++++    L   LD +++   NLE + R
Sbjct: 1408 YEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQR 1451


>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
            sapiens]
          Length = 1983

 Score = 73.9 bits (180), Expect = 3e-13
 Identities = 105/506 (20%), Positives = 207/506 (40%), Gaps = 86/506 (16%)

Query: 77   ELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKL-------EM 129
            ELE   + AA ++K  R         R +  +++ E  +A+ E R L  +L       E 
Sbjct: 1480 ELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEE 1539

Query: 130  AMKELSTLKKK----------------------QSLPPQKEALEANVTQDLKLPGFVEES 167
            A++ L TLK++                      Q L   K+ALE   ++        E +
Sbjct: 1540 ALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGA 1599

Query: 168  CEHTDQFQLSSQMHESIREYLVKRQFSTKEDT-----NNKEQGVVI-------------D 209
             E  +   L  Q+  S  +  V R+ + K++       N ++ V               +
Sbjct: 1600 LELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNE 1659

Query: 210  SLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLENEVTEISALQVHLDEFQK 269
            +L+L ++M+ +L+ ++L   G +    T+     + +   L+ E       Q   DE Q+
Sbjct: 1660 ALRLKKKMEGDLNDLEL-QLGHATRQATEAQAATRLMQAQLKEE-------QAGRDEEQR 1711

Query: 270  ILWKEREMRTALEK-------EIERLESALSLWKWKYEELKESKPKNVKEFDILLGQHND 322
            +  +  E   ALE+       E+E L +AL   +      ++   +  +  ++L  Q+  
Sbjct: 1712 LAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTG 1771

Query: 323  ----------EMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWDKREILERE 372
                      ++ +LSG ++E ++ +   +    +   +   +  E   E D    LER 
Sbjct: 1772 LLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERM 1831

Query: 373  KQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDL---QEKNQELLNLQHA 429
            K+ LE+  R L+ +++E E+   +  +          +  + +L   Q+K+ E L     
Sbjct: 1832 KKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEAL----- 1886

Query: 430  YYKLNRQYQANIAELTHANNRVDQNEAE----VKKLRLRVEELKQGLNQKEDELDDSLNQ 485
              K  R+++  + EL +      +N A     V KL+ +V+  K+   + E + + +L +
Sbjct: 1887 --KGVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQANTNLAK 1944

Query: 486  IRKLQRSLDEEKERNENLETELRHLQ 511
             RK Q  LD+ +ER +  ET+   L+
Sbjct: 1945 YRKAQHELDDAEERADMAETQANKLR 1970



 Score = 56.2 bits (134), Expect = 7e-08
 Identities = 51/236 (21%), Positives = 105/236 (44%), Gaps = 9/236 (3%)

Query: 273  KEREMRTALEKEIERLESALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIK 332
            K +E+   LE E E + + L+  + K E+      K++ +  + L +   E Q     +K
Sbjct: 967  KVKELSERLEDE-EEVNADLAARRRKLEDECTELKKDIDDLKLTLAKAEKEKQATENKVK 1025

Query: 333  EESKSQNSKDRVICELRAELERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEE 392
              ++   + D  +  L  E + LQ  +       +  E     L +   RL+ QV+++E 
Sbjct: 1026 NLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLEC 1085

Query: 393  LLDKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVD 452
             L+++ +L  +++    K+   DL+   + + +      +L  + +   +EL+  + RV+
Sbjct: 1086 SLEQEKKLRMDTERAKRKLEG-DLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVE 1144

Query: 453  -------QNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNE 501
                   Q + ++K+L+ R EEL++ L  +         Q  +  R L+E  ER E
Sbjct: 1145 DEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLE 1200



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 98/456 (21%), Positives = 194/456 (42%), Gaps = 54/456 (11%)

Query: 72   ELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAM 131
            +L LR +E+ +   AQM+K ++   +  A   E   ++ AER +AR    + R +    +
Sbjct: 1138 QLSLR-VEDEQLLGAQMQKKIK---ELQARAEELEEELEAER-AARARVEKQRAEAAREL 1192

Query: 132  KELSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCE--HTDQFQLSSQMHES-IREYL 188
            +ELS   +        EA  A+  Q         E C     +  +L  ++ E+ +R   
Sbjct: 1193 EELSERLE--------EAGGASAGQ--------REGCRKREAELGRLRRELEEAALRHEA 1236

Query: 189  VKRQFSTKEDTNNKEQGVVIDSL-KLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAIN 247
                   K+     E G  +DSL ++ ++++     + +  +  + N ET T  +  A  
Sbjct: 1237 TVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEK 1296

Query: 248  LPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELKESKP 307
            L    E  ++S  ++ ++E Q+ L      R  L+ E   L   L        E KE   
Sbjct: 1297 LCRTYE-DQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLL--------EEKECLI 1347

Query: 308  KNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWDKRE 367
              +     L  Q    ++EL   ++EESK++++    +  LR + + L+ ++  E + + 
Sbjct: 1348 SQLSRGKALAAQ---SLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQA 1404

Query: 368  ILER--EKQGLERENRRLKIQ---VKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQE 422
             L+R   K   E    R K +   ++  EEL + K +L+   Q      ++  ++  N +
Sbjct: 1405 ELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQE-----AEEGVEAANAK 1459

Query: 423  LLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDS 482
              +L+ A  +L  + +    EL  A +     + + + L   +EE ++   + + EL+ +
Sbjct: 1460 CSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAA 1519

Query: 483  LNQIR-------KLQRSLDEEKERNENLETELRHLQ 511
              + R       +L+   +E  E  E L+ E ++LQ
Sbjct: 1520 QRESRGLGTELFRLRHGHEEALEALETLKRENKNLQ 1555



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 60/269 (22%), Positives = 120/269 (44%), Gaps = 34/269 (12%)

Query: 260  LQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELKESKPKNVKEFDILLGQ 319
            L+  +++ +  L +E+++R   E+   +LE  L L +    +  + K    ++ +  L +
Sbjct: 1076 LEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDK----QQLEEKLKK 1131

Query: 320  HNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWDKREILEREKQGLERE 379
             + E+ +LS  +++E        + I EL+A  E L+ E  +E   R  +E+++    RE
Sbjct: 1132 KDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARE 1191

Query: 380  NRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELLN--LQH-----AYYK 432
                   ++E+ E L++    SA  Q    +  + +L    +EL    L+H     A  +
Sbjct: 1192 -------LEELSERLEEAGGASAG-QREGCRKREAELGRLRRELEEAALRHEATVAALRR 1243

Query: 433  LNRQYQANIAELTHANNRVDQN-EAEVKKLRLRVEELKQGLNQK--------------ED 477
               +  A + E   +  RV Q  E E  +LR+ V++L   +                 ED
Sbjct: 1244 KQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYED 1303

Query: 478  ELDDSLNQIRKLQRSLDEEKERNENLETE 506
            +L ++  ++ +LQR L +   +   L+TE
Sbjct: 1304 QLSEAKIKVEELQRQLADASTQRGRLQTE 1332



 Score = 39.3 bits (90), Expect = 0.009
 Identities = 55/249 (22%), Positives = 107/249 (42%), Gaps = 27/249 (10%)

Query: 270  ILWKEREMRTALEKEIERLESALSLWKWKYEELKESKPK------NVKEFDILLGQHNDE 323
            +L + R+ R A    + +  S   L + +Y+ L   +        N++ F+ +    N  
Sbjct: 821  VLEELRDQRLAKVLTLLQARSRGRLMRLEYQRLLGGRDALFTIQWNIRAFNAV---KNWS 877

Query: 324  MQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWDKREILEREKQGLERENRRL 383
              +L   +K   +S  +++  +  LRAEL  L+    +   KR+ LE     + +E   L
Sbjct: 878  WMKLFFKMKPLLRSAQAEEE-LAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDL 936

Query: 384  KIQVK-EMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIA 442
             +Q++ E + L D + R            S++ L+ K +EL        +L  + + N A
Sbjct: 937  ALQLQAEQDNLADAEERCHL------LIKSKVQLEGKVKELSE------RLEDEEEVN-A 983

Query: 443  ELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNEN 502
            +L     +++    E+KK    +++LK  L + E E   + N+++ L   +    E    
Sbjct: 984  DLAARRRKLEDECTELKK---DIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVAR 1040

Query: 503  LETELRHLQ 511
            L  E + LQ
Sbjct: 1041 LTKEKKALQ 1049


>gi|46049114 M-phase phosphoprotein 1 [Homo sapiens]
          Length = 1780

 Score = 73.9 bits (180), Expect = 3e-13
 Identities = 96/457 (21%), Positives = 191/457 (41%), Gaps = 63/457 (13%)

Query: 76   RELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAMKELS 135
            ++ EEV+   A++E  +R   +     R     +  E  + +EE  +L  ++    +ELS
Sbjct: 822  KKSEEVRPNIAEIED-IRVLQENNEGLRAFLLTIENELKNEKEEKAELNKQIVHFQQELS 880

Query: 136  TLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIREYLVKRQFST 195
             L +K++L   KE  +     D+ +     +  ++ +Q        E I +   + + +T
Sbjct: 881  -LSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQ-------EEKIMKLSNEIETAT 932

Query: 196  KEDTNNKEQ----GVVIDSLKLSEEMKPNLDGVDLFN-----NGGSGNGETKTGLRLKAI 246
            +  TNN  Q       ID L+  + +   +  +DL N     NG   +    T L L   
Sbjct: 933  RSITNNVSQIKLMHTKIDELRTLDSVS-QISNIDLLNLRDLSNGSEEDNLPNTQLDLLGN 991

Query: 247  NLPLENEVTE---------------ISALQVHLDEFQKILWKEREMRTALEKEIERLESA 291
            +  +  +V E               I A+     E  K   K+      LE++IE+L++ 
Sbjct: 992  DYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAE 1051

Query: 292  LSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAE 351
            +  +K +   LKE + KN    D LL +    +Q+L   ++E++ + + + + + E +  
Sbjct: 1052 VKGYKDENNRLKEKEHKNQ---DDLLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRA 1108

Query: 352  LERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKM 411
            L  L    T                       K ++KE+E +L+ +    ++S     K+
Sbjct: 1109 LSELTQGVTC---------------------YKAKIKELETILETQKVECSHSA----KL 1143

Query: 412  SQIDLQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQG 471
             Q D+ EK   +L L+    +     Q ++      N +  + + E+ +L   ++++K  
Sbjct: 1144 EQ-DILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHL 1202

Query: 472  LNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELR 508
            L  KE+E + +  +  KL+  L     R +NL+ +L+
Sbjct: 1203 LQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQ 1239



 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 99/463 (21%), Positives = 201/463 (43%), Gaps = 98/463 (21%)

Query: 60   HSYNTNKWDICEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREE 119
            HS     W+ C+E+    ++    ++ Q+E+             ++  K++AE    ++E
Sbjct: 1014 HSSIEAIWEECKEI----VKASSKKSHQIEEL-----------EQQIEKLQAEVKGYKDE 1058

Query: 120  GRQLRIKLEMAMKELSTLKKKQSLPPQ--KEALEANVTQDLKLPGFVEESCEHTDQFQLS 177
              +L+ K      +L  LK+K++L  Q  +E  E NVT D+++   VE         +  
Sbjct: 1059 NNRLKEKEHKNQDDL--LKEKETLIQQLKEELQEKNVTLDVQIQHVVEGK-------RAL 1109

Query: 178  SQMHESIREYLVK-RQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGE 236
            S++ + +  Y  K ++  T  +T   E      S KL +++                   
Sbjct: 1110 SELTQGVTCYKAKIKELETILETQKVECS---HSAKLEQDI------------------- 1147

Query: 237  TKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWK 296
                L  ++I L LE  + E    Q HL +  K           L++EI +L + L   K
Sbjct: 1148 ----LEKESIILKLERNLKEF---QEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMK 1200

Query: 297  WKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELER-- 354
               +  +E +  N +E + L        +ELS +    +++QN        L+A+L+R  
Sbjct: 1201 HLLQLKEEEEETNRQETEKL-------KEELSAS---SARTQN--------LKADLQRKE 1242

Query: 355  -----LQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDF 409
                 L+ + T    + + +++E   +  E++ L+I++ E+E+   KKN+ S      + 
Sbjct: 1243 EDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEK---KKNQCSQ-----EL 1294

Query: 410  KMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELK 469
             M Q  +Q+  ++L N         ++ +  I +   A   ++  E  ++ +R+ +EE +
Sbjct: 1295 DMKQRTIQQLKEQLNN---------QKVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQE 1345

Query: 470  QGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRHLQN 512
            Q   +++  L+  L ++ +L   L++ KE+  +LET+     N
Sbjct: 1346 QTQVEQDQVLEAKLEEVERLATELEKWKEKCNDLETKNNQRSN 1388



 Score = 56.2 bits (134), Expect = 7e-08
 Identities = 104/498 (20%), Positives = 211/498 (42%), Gaps = 84/498 (16%)

Query: 50   QSHAAHNFCAHSYNTNKWDICEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKV 109
            +  AA + CA    T +   C EL+  +++      A++ KT           + +  K 
Sbjct: 652  REEAAKDICATKVETEEATACLELKFNQIK------AELAKT-----------KGELIKT 694

Query: 110  RAERNSAREEGRQLRIKLEMAMKELST----LKKKQSLPPQKEALEANVTQDLKLPGFVE 165
            + E      E   L  +LE + K++ T    +K+  ++  QKE    N  Q+LK    +E
Sbjct: 695  KEELKKRENESDSLIQELETSNKKIITQNQRIKELINIIDQKED-TINEFQNLK--SHME 751

Query: 166  ESCEHTDQFQLSSQM-------HESI-------------REYLVKRQFSTKEDTNNK--- 202
             + +  D+   SS +       +E++             R+ + + +    E    K   
Sbjct: 752  NTFKCNDKADTSSLIINNKLICNETVEVPKDSKSKICSERKRVNENELQQDEPPAKKGSI 811

Query: 203  -EQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLR--LKAINLPLENEVTEISA 259
                 + +  K SEE++PN+  ++          E   GLR  L  I   L+NE  E + 
Sbjct: 812  HVSSAITEDQKKSEEVRPNIAEIEDIR----VLQENNEGLRAFLLTIENELKNEKEEKAE 867

Query: 260  LQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELKESKPKNVKEFDILLGQ 319
            L   +  FQ+ L    +    L KE+++++S   +      EL   K KN ++       
Sbjct: 868  LNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDI---AIAELHVQKSKNQEQ------- 917

Query: 320  HNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQA-ENTSEWDKREILEREKQGLER 378
              +++ +LS  I+  ++S  +    I  +  +++ L+  ++ S+    ++L         
Sbjct: 918  -EEKIMKLSNEIETATRSITNNVSQIKLMHTKIDELRTLDSVSQISNIDLL--------- 967

Query: 379  ENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYYK-LNRQY 437
             N R      E + L + +  L  N      ++ +  +QE N+E  N  H+  + +  + 
Sbjct: 968  -NLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRE--NSFHSSIEAIWEEC 1024

Query: 438  QANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQ-KEDE---LDDSLNQIRKLQRSL 493
            +  +   +  ++++++ E +++KL+  V+  K   N+ KE E    DD L +   L + L
Sbjct: 1025 KEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLKEKETLIQQL 1084

Query: 494  DEE-KERNENLETELRHL 510
             EE +E+N  L+ +++H+
Sbjct: 1085 KEELQEKNVTLDVQIQHV 1102



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 75/345 (21%), Positives = 151/345 (43%), Gaps = 42/345 (12%)

Query: 77   ELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAMKELST 136
            EL    AR   ++  ++   +  A+ +EK +  + +    ++E   +R + ++   +++ 
Sbjct: 1223 ELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINE 1282

Query: 137  LKKKQSLPPQKEALEANVTQDLKLP---GFVEESCEHTDQFQLSSQMHESIREYLVKRQF 193
            L+KK++   Q+  ++    Q LK       VEE+ +  ++      + E I E +  R  
Sbjct: 1283 LEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIEDM--RMT 1340

Query: 194  STKEDTNNKEQGVVIDSLKLS---------EEMKPNLDGVDLFNNGGSG-NGETKTGLRL 243
              +++    EQ  V+++ KL          E+ K   + ++  NN  S    E  T +  
Sbjct: 1341 LEEQEQTQVEQDQVLEA-KLEEVERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLG 1399

Query: 244  KAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELK 303
            K  NL  E + +E    Q +  + +K L +E+ M     KE E + +       KY E +
Sbjct: 1400 KLTNLQDELQESE----QKYNADRKKWL-EEKMMLITQAKEAENIRNKEMK---KYAEDR 1451

Query: 304  ESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEW 363
            E   K   E +IL  Q  ++  +L        K +  +D+++  L  +L+ L + N  + 
Sbjct: 1452 ERFFKQQNEMEILTAQLTEKDSDL-------QKWREERDQLVAALEIQLKALISSNVQKD 1504

Query: 364  DKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPD 408
            ++ E L+R    +  E  +++ Q+ ++     K  R+S  S  PD
Sbjct: 1505 NEIEQLKR----IISETSKIETQIMDI-----KPKRIS--SADPD 1538



 Score = 35.4 bits (80), Expect = 0.13
 Identities = 53/253 (20%), Positives = 106/253 (41%), Gaps = 30/253 (11%)

Query: 270 ILWKEREMRTALEKE--IERLESALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQEL 327
           I W E  +   +E E  +E LE+A      + + L E   K ++E    +   ++E ++L
Sbjct: 520 ISW-ENSLEDLMEDEDLVEELENAEETQNVETKLLDEDLDKTLEENKAFIS--HEEKRKL 576

Query: 328 SGNIKEESKS--QNSKDRVICELRAELERLQAENTSEWDKREILEREKQGLERE------ 379
              I++  K      K+++  E +   E +  E T  W +RE   +E    ERE      
Sbjct: 577 LDLIEDLKKKLINEKKEKLTLEFKIR-EEVTQEFTQYWAQREADFKETLLQEREILEENA 635

Query: 380 NRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQA 439
            RRL I     ++L+ K +  +    + D   ++++ +E          A   L  ++  
Sbjct: 636 ERRLAI----FKDLVGKCD--TREEAAKDICATKVETEE----------ATACLELKFNQ 679

Query: 440 NIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKER 499
             AEL      + + + E+KK     + L Q L     ++     +I++L   +D++++ 
Sbjct: 680 IKAELAKTKGELIKTKEELKKRENESDSLIQELETSNKKIITQNQRIKELINIIDQKEDT 739

Query: 500 NENLETELRHLQN 512
               +    H++N
Sbjct: 740 INEFQNLKSHMEN 752


>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
            sapiens]
          Length = 1940

 Score = 73.6 bits (179), Expect = 4e-13
 Identities = 102/495 (20%), Positives = 218/495 (44%), Gaps = 64/495 (12%)

Query: 77   ELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKL-------EM 129
            ++E   + AA ++K  R +    A W+ K  + +AE  ++ +E R L  +L       E 
Sbjct: 1432 DVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEE 1491

Query: 130  AMKELSTLKKKQSLPPQKEA-LEANVTQDLKLPGFVEESCEHTDQFQLSSQM-------- 180
            A+ +L T+K++     Q+ A L   + ++ K    +E+S +  +  +   Q+        
Sbjct: 1492 ALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAA 1551

Query: 181  --HES---IREYLVKRQFSTKEDTNNKEQGVVIDSLKLS-----EEMKPNLDGVDLFNNG 230
              HE    +R  L   Q  ++ D    E+   I+ LK +     E M+  LD      N 
Sbjct: 1552 LEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNE 1611

Query: 231  GSGNGETKTG------LRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKE 284
                 +   G      ++L   N      +  + ++Q  L + Q  L      +  L+++
Sbjct: 1612 AIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQ 1671

Query: 285  IERLESALSLWKWKYEELKES-----KPKNVKEFDILLGQHNDEMQELSGNIKEESKSQN 339
            +  +E   +L + + EEL+ +     + + + E ++L    N+ +Q L         ++ 
Sbjct: 1672 LAIVERRANLLQAEVEELRATLEQTERARKLAEQELL--DSNERVQLLHTQNTSLIHTKK 1729

Query: 340  SKDRVICELRAELERLQ--AENTSEWDKREI---------LEREKQG---LERENRRLKI 385
              +  + +L++E+E     A N  E  K+ I         L++E+     LER  + L+ 
Sbjct: 1730 KLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQ 1789

Query: 386  QVKEMEELLDKKNRLSANS-----QSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQAN 440
             VK+++  LD+  +L+        Q  + ++ +++ + + ++  N +    K  R+Y+  
Sbjct: 1790 TVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESV--KGLRKYERR 1847

Query: 441  IAELTHANNRVDQNEAE----VKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEE 496
            + ELT+ +    +N       V KL+++V+  K+   + +++ +  L + RK Q  L+E 
Sbjct: 1848 VKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEA 1907

Query: 497  KERNENLETELRHLQ 511
            +ER +  E+++  L+
Sbjct: 1908 EERADIAESQVNKLR 1922



 Score = 69.3 bits (168), Expect = 8e-12
 Identities = 94/464 (20%), Positives = 197/464 (42%), Gaps = 54/464 (11%)

Query: 84   RAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAMKELSTLK----- 138
            ++A+ EK M       A  +E++ K + E   +  + ++L  KL   ++E + L+     
Sbjct: 842  KSAETEKEM-------ATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQA 894

Query: 139  KKQSLPPQKEALEANVTQDLKLPGFVEESCEHT-DQFQLSSQMHESIREYLVKRQFSTKE 197
            + ++L   +E  +  +    +L   ++E  E   D+ ++++++    R+ L       K+
Sbjct: 895  ESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRK-LEDECSELKK 953

Query: 198  DTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGET--KTGLRLKAINLPLENEVT 255
            D ++ E    +   K+ +E     + V       SG  ET  K     KA+    +  + 
Sbjct: 954  DIDDLE----LTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALD 1009

Query: 256  EISA--------------LQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEE 301
            ++ A              L+  +++ +  L +E+++R  LE+   +LE  L L +    +
Sbjct: 1010 DLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILD 1069

Query: 302  LKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTS 361
            L+  K    ++ D  L + + E  +L   +++E        + I EL+A +E L+ E  +
Sbjct: 1070 LENDK----QQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEA 1125

Query: 362  EWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQ 421
            E   R   E+++    RE   L  +++E   +   +  L+   ++   K+ + DL+E   
Sbjct: 1126 ERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRR-DLEEATL 1184

Query: 422  ELLNLQHAYYKLNRQYQANIAELTHANNRVDQN-EAEVKKLRLRVEELKQGLNQK----- 475
            +   +  A  K +    A + E      RV Q  E E  + +L +++L   +        
Sbjct: 1185 QHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKA 1244

Query: 476  ---------EDELDDSLNQIRKLQRSLDEEKERNENLETELRHL 510
                     ED+L ++  +  ++QRSL E   +   L+TE   L
Sbjct: 1245 NLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGEL 1288



 Score = 57.0 bits (136), Expect = 4e-08
 Identities = 99/453 (21%), Positives = 193/453 (42%), Gaps = 75/453 (16%)

Query: 68   DICEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWS-------KVRAERNSAREEG 120
            D C EL+ +++++++   A++EK      +   N  E+ S       K+  E+ + +E  
Sbjct: 946  DECSELK-KDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAH 1004

Query: 121  RQLRIKLEMAMKELSTLKK-KQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQ 179
            +Q    L+    ++++L K K  L  Q E LE+++ Q+ KL   +E +            
Sbjct: 1005 QQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERN------------ 1052

Query: 180  MHESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKT 239
                +   L   Q S  +  N+K+Q        L E +K      +          E   
Sbjct: 1053 -KRKLEGDLKLAQESILDLENDKQQ--------LDERLKKK--DFEYCQLQSKVEDEQTL 1101

Query: 240  GLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKY 299
            GL+ +           +I  LQ  ++E ++ +  ER  R   EK+  R + A  L     
Sbjct: 1102 GLQFQK----------KIKELQARIEELEEEIEAERATRAKTEKQ--RSDYAREL----- 1144

Query: 300  EELKE--SKPKNVKEFDILLGQHND-EMQELSGNIKEESKSQNSKDRVICELRAELERLQ 356
            EEL E   +   V    I L +  + E  +L  +++E +    +       + A L +  
Sbjct: 1145 EELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEA-------MVAALRKKH 1197

Query: 357  AENTSEWDKR-EILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQID 415
            A++ +E  ++ + L+R KQ LE+E    K+++ ++   ++  ++  AN       + +I 
Sbjct: 1198 ADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKAN-------LEKIC 1250

Query: 416  LQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQK 475
               ++Q    L  A  K N + Q +++ELT   +R+   + E  +L  ++EE +  ++Q 
Sbjct: 1251 RTLEDQ----LSEARGK-NEEIQRSLSELTTQKSRL---QTEAGELSRQLEEKESIVSQL 1302

Query: 476  EDELDDSLNQIRKLQRSLDEEKERNENLETELR 508
                     Q  +L+R L+EE +    L   L+
Sbjct: 1303 SRSKQAFTQQTEELKRQLEEENKAKNALAHALQ 1335



 Score = 55.8 bits (133), Expect = 9e-08
 Identities = 87/460 (18%), Positives = 191/460 (41%), Gaps = 53/460 (11%)

Query: 78   LEEVKARAAQMEKTMRWWSDCTANWREK-------WSKVRAERNSAREEGRQLRIKLEMA 130
            +E V    A +EK  R   D  +  R K        S++  +++  + E  +L  +LE  
Sbjct: 1236 MESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEK 1295

Query: 131  MKELSTLKK-KQSLPPQKEALEANVTQDLKLPGFVEESCEHT--------DQFQLSSQMH 181
               +S L + KQ+   Q E L+  + ++ K    +  + + +        +Q++   +  
Sbjct: 1296 ESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGK 1355

Query: 182  ESIREYLVKR-----QFSTKEDTNNKEQGVVIDSLK--LSEEMKPNLDGVDLFNNGGSGN 234
              ++  L K      Q+ TK +T+  ++   ++  K  L++ ++ + + V+  N   +  
Sbjct: 1356 AELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASL 1415

Query: 235  GETKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSL 294
             +TK  L+             E+  L V ++       +   +  AL+K+    +  L+ 
Sbjct: 1416 EKTKQRLQ------------GEVEDLMVDVE-------RANSLAAALDKKQRNFDKVLAE 1456

Query: 295  WKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELER 354
            WK K EE +     ++KE   L    + E+ +L    +E      +  R    L  E+  
Sbjct: 1457 WKTKCEESQAELEASLKESRSL----STELFKLKNAYEEALDQLETVKRENKNLEQEIAD 1512

Query: 355  LQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKM-SQ 413
            L  +          LE+ ++ +E E   +++ ++E E  L+ +       Q    ++ S+
Sbjct: 1513 LTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSE 1572

Query: 414  ID--LQEKNQELLNLQHAYYKLNRQYQANI-AELTHANNRV---DQNEAEVKKLRLRVEE 467
            ID  + EK++E+  L+  Y +     Q+ + AE+   N  +    + E ++ ++ +++  
Sbjct: 1573 IDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSH 1632

Query: 468  LKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETEL 507
              +   +    L     Q++  Q  LD+     E+L+ +L
Sbjct: 1633 ANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQL 1672



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 89/396 (22%), Positives = 160/396 (40%), Gaps = 56/396 (14%)

Query: 77   ELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEG--RQLRIKLEMAMKEL 134
            E+E++K    +  +TM+   D      E  S+  A R   + EG   ++ I+L  A ++ 
Sbjct: 1583 EIEQLKRNYQRTVETMQSALDA-----EVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQA 1637

Query: 135  S-TLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIREYLVKRQF 193
            + TLK  +S+  Q +  + ++   L+    ++E     ++         ++ +  V+   
Sbjct: 1638 AETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVER-------RANLLQAEVEELR 1690

Query: 194  STKEDTNNKEQGVVIDSLKLSE-EMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLEN 252
            +T E T            KL+E E+  + + V L +   +    TK  L    + L  E 
Sbjct: 1691 ATLEQTERAR--------KLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEV 1742

Query: 253  EVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELKESKPKNVKE 312
            E     A     ++ +K +     M   L+KE +             E +K++  + VK+
Sbjct: 1743 EDASRDARNAE-EKAKKAITDAAMMAEELKKEQDTSAHL--------ERMKKNLEQTVKD 1793

Query: 313  FDILLGQHN-DEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWDKREILER 371
                  QH  DE ++L+  +K   K     +  I EL  ELE  Q +NT           
Sbjct: 1794 L-----QHRLDEAEQLA--LKGGKKQIQKLETRIRELEFELEGEQKKNTES--------- 1837

Query: 372  EKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYY 431
              +GL +  RR+K    + EE  D+KN L         ++     + + +E     +A+ 
Sbjct: 1838 -VKGLRKYERRVKELTYQSEE--DRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHL 1894

Query: 432  KLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEE 467
               R+ Q    EL  A  R D  E++V KLR +  +
Sbjct: 1895 TKFRKAQH---ELEEAEERADIAESQVNKLRAKTRD 1927


>gi|4502443 dystonin isoform 1e precursor [Homo sapiens]
          Length = 2649

 Score = 73.6 bits (179), Expect = 4e-13
 Identities = 92/424 (21%), Positives = 186/424 (43%), Gaps = 46/424 (10%)

Query: 117  REEGRQLRI---KLEMAMKELSTLKK--------KQSLPPQKEALEANVTQDLKLPGFVE 165
            RE GRQL     K E AM+E S LKK         +SL  +K  L+  V +  +     E
Sbjct: 1439 RELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAE 1498

Query: 166  ESCEHTDQFQLSSQMHESIREYLVKR-QFSTKEDTNNKEQ-----GVVIDSLKLSEEMKP 219
            ++ +H     L+SQ+H    E  ++R Q   ++  + KEQ       ++ ++K  +E   
Sbjct: 1499 KNIQH-----LNSQIHSFRDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKE--- 1550

Query: 220  NLDGVDLFNNGGSGNGETKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRT 279
            N D +   N     + E    L+ K   L  +N  T++   ++  +    +L K+     
Sbjct: 1551 NNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQ----- 1605

Query: 280  ALEKEIERLESALSLWKWKYEELKESKPKNVK---EFDILLGQHNDEMQELSGNIKEESK 336
             +++  E L+     +K +     E   K  K   +F   +    +++ +    + E  +
Sbjct: 1606 TIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQ 1665

Query: 337  SQNSKDRVICELRAELERLQAE-NTSEWDKR----EILEREKQGLERENRRLKIQ----V 387
              + ++ +I   + E+  L AE N S+ +KR    ++  ++ Q  E  NR  K+Q    +
Sbjct: 1666 KCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHL 1725

Query: 388  KEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAELTHA 447
            K +EE +  +  +    +S  FK S  + ++K ++L+  +          + +   L   
Sbjct: 1726 KTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRLDFVSLQQE 1785

Query: 448  NNRVDQN----EAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENL 503
            N+R  +N    E  +K+L  ++++ ++ + Q +    +   + +KL+  L  +K   ENL
Sbjct: 1786 NSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENL 1845

Query: 504  ETEL 507
            + ++
Sbjct: 1846 KQKM 1849



 Score = 42.7 bits (99), Expect = 8e-04
 Identities = 66/288 (22%), Positives = 125/288 (43%), Gaps = 53/288 (18%)

Query: 248 LPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELKESKP 307
           LP E++   +S LQ   ++F   L   +E +     +I +LE  +++ K  Y+EL +S  
Sbjct: 675 LPGEHQQV-LSNLQSRFEDF---LEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAE 730

Query: 308 KNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWDKRE 367
           +  +E  +    +N  + E+  NI+   + +N +DR+I ++R  LER     +       
Sbjct: 731 REEQEESV----YNLYISEVR-NIR--LRLENCEDRLIRQIRTPLERDDLHESVF----R 779

Query: 368 ILEREKQGLERENRRLKIQV------------------------KEMEELLDKKNRLSAN 403
           I E+EK  L++E  RLK  +                         E+  +L   N++ + 
Sbjct: 780 ITEQEK--LKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSM 837

Query: 404 SQSPDFKMSQIDLQEKNQELLNLQHAYYKLNR-QYQANIAELTHANNRVDQNEAEVKKLR 462
           S +   K+  ++L  KN +        Y+    + +A IA+  +  N +    + +K+ R
Sbjct: 838 SSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI----STLKQWR 893

Query: 463 LRVEELKQGLNQKEDEL-------DDSLNQIRKLQRSLDEEKERNENL 503
             V+E +Q  +  EDEL       D+     ++     D  KE+ + L
Sbjct: 894 SEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQL 941



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 76/406 (18%), Positives = 170/406 (41%), Gaps = 43/406 (10%)

Query: 119  EGRQLRIKLEMAMKELSTLKKKQS-----LPPQKEALEANVTQDLKLPGFVEESCEHTDQ 173
            E  +L  K+    + ++ LKK++S     LP  +EA E  + +  +    VE+      +
Sbjct: 1132 ENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQQRN---VEDISLQKIR 1188

Query: 174  FQLSSQMHESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSG 233
             +  ++ +    E +V+ + + + +     Q + I++      ++ NL     F N    
Sbjct: 1189 AESEAKQYRRELETIVREKEAAERELERVRQ-LTIEAEAKRAAVEENLLN---FRNQLEE 1244

Query: 234  NGETKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALS 293
            N  T+     + +   L+ +   ++ L+   ++  + L ++R+    L K I+++E  L+
Sbjct: 1245 NTFTR-----RTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLA 1299

Query: 294  LWKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESK-----SQNSKDRVICEL 348
              K   E       K +KE   +  +   ++ E+    +E +      +Q +  R +  L
Sbjct: 1300 FQKQVAE-------KQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAVTGL 1352

Query: 349  RAELERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPD 408
            + E ++ +AE          L+++   L   NR+ +   ++M EL  + N L     S +
Sbjct: 1353 QQEHDKQKAEE---------LKQQVDELTAANRKAE---QDMRELTYELNALQLEKTSSE 1400

Query: 409  FKMSQID--LQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVE 466
             K   +   L E N  L  L+    + ++  +    +L     +++Q   + ++      
Sbjct: 1401 EKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEAS 1460

Query: 467  ELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRHLQN 512
            +LK+     + EL+   ++  KLQR +D     +   E  ++HL +
Sbjct: 1461 DLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNS 1506



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 62/310 (20%), Positives = 125/310 (40%), Gaps = 32/310 (10%)

Query: 214  SEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWK 273
            +EE+K  +D +   N     +    T   L A+ L   +   +   L+  LDE    L  
Sbjct: 1361 AEELKQQVDELTAANRKAEQDMRELT-YELNALQLEKTSSEEKARLLKDKLDETNNTL-- 1417

Query: 274  EREMRTALEKEIERLESALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQ-------E 326
                   L+ E+ER + A   +  +  EL     +   + +  + + +D  +       E
Sbjct: 1418 -----RCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLE 1472

Query: 327  LSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWDKREILEREK-QGLERENRRLKI 385
            L     E+ K Q   DR+        + +Q  N+     R+  E E+ Q  +R++  LK 
Sbjct: 1473 LESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKELERLQICQRKSDHLKE 1532

Query: 386  QVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAELT 445
            Q ++  E L     + A  ++ D       +Q  N+EL         L ++    + ELT
Sbjct: 1533 QFEKSHEQL--LQNIKAEKENND------KIQRLNEELEKSNECAEMLKQK----VEELT 1580

Query: 446  HANNR----VDQNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNE 501
              NN     + + +AE + + L  + ++Q     + + D   +Q+R     L ++ +  +
Sbjct: 1581 RQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQ 1640

Query: 502  NLETELRHLQ 511
            + + +++ L+
Sbjct: 1641 DFQRKIKCLE 1650



 Score = 39.3 bits (90), Expect = 0.009
 Identities = 77/370 (20%), Positives = 158/370 (42%), Gaps = 43/370 (11%)

Query: 78   LEEVKARAAQMEKTMRW------WSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAM 131
            L+ +KA     +K  R        ++C    ++K  ++  + N  +   ++++ + E  +
Sbjct: 1542 LQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAESENIV 1601

Query: 132  KELSTLKKKQSLPPQKEAL--EANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIREYLV 189
             E      KQ++  + EAL  +A+  +D +L    E   + T   Q   +  + + E L 
Sbjct: 1602 LE------KQTIQQRCEALKIQADGFKD-QLRSTNEHLHKQTKTEQDFQRKIKCLEEDLA 1654

Query: 190  KRQFSTKEDTNN-KEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINL 248
            K Q    E      +Q ++I + K  +E++ NL+     +      GE K  L+   +  
Sbjct: 1655 KSQNLVSEFKQKCDQQNIIIQNTK--KEVR-NLNAELNASKEEKRRGEQKVQLQQAQVQ- 1710

Query: 249  PLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELKESKPK 308
             L N + ++   ++HL   ++ +   R+M    ++E  + + +   ++ K E+L ESK  
Sbjct: 1711 ELNNRLKKVQD-ELHLKTIEEQM-THRKM-VLFQEESGKFKQSAEEFRKKMEKLMESKVI 1767

Query: 309  NVKEFD------ILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSE 362
               +        + L Q N   QE   N K    +    +R + + R ++++ Q    + 
Sbjct: 1768 TENDISGIRLDFVSLQQENSRAQE---NAKLCETNIKELERQLQQYREQMQQGQHMEANH 1824

Query: 363  WDKREILERE----KQGLERENRRLKIQVKEMEELL-------DKKNRLSANSQSPDFKM 411
            + K + LE E    K+ +E   +++  Q+KE E  L        KK+     +  PDF+M
Sbjct: 1825 YQKCQKLEDELIAQKREVENLKQKMDQQIKEHEHQLVLLQCEIQKKSTAKDCTFKPDFEM 1884

Query: 412  SQIDLQEKNQ 421
            +  + Q   +
Sbjct: 1885 TVKECQHSGE 1894


>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
          Length = 1417

 Score = 73.2 bits (178), Expect = 5e-13
 Identities = 96/468 (20%), Positives = 203/468 (43%), Gaps = 66/468 (14%)

Query: 77   ELEEVKARAAQMEKTMRWWSD---CTANWREKWSKVRAERNSAREEGRQLRIKLEMAMKE 133
            +LE+   +  + EKTM        C  +  E   ++  E   ++ E ++  +K + A+K 
Sbjct: 776  QLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTE---SKGEMKKENMKKDEALKA 832

Query: 134  LSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHE------SIREY 187
            L     ++++  ++         D  L    EE   H +Q + + +  E      S   Y
Sbjct: 833  LQNQVSEETIKVRQ--------LDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVY 884

Query: 188  LVKRQFSTKEDT--NNKEQGVVID-SLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLK 244
             ++++   K  +     EQ V++  +L+  ++M       +   NG   + +TK   ++ 
Sbjct: 885  CLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQ----ETIRNGELEDTQTKLEKQVS 940

Query: 245  AINLPLENEVTEISALQVHLDEFQKILWKEREMR---------TALEKEIE--RLESALS 293
             +   L+ +    +     ++E  +    E +++         TA + +IE  + +  LS
Sbjct: 941  KLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELS 1000

Query: 294  LWKWKYEELK---ESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRA 350
              + +   LK   E+K  ++ + D++L Q   E+++ +  +KE  K Q+S +        
Sbjct: 1001 KMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTE-------- 1052

Query: 351  ELERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDK------KNRLSANS 404
                   E T    KRE+LE E Q    E +    Q++E+ ++L K      +   +   
Sbjct: 1053 ------TELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKD 1106

Query: 405  QSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLR 464
             + + +  ++++++K QELL +  A  + N + +   A++TH +  + ++  E+++   +
Sbjct: 1107 LTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQ---K 1163

Query: 465  VEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRHLQN 512
            + +L+  L + E EL +   QI  L   L   KE+    E E   LQN
Sbjct: 1164 IIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLR--EKEFIMLQN 1209



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 88/409 (21%), Positives = 174/409 (42%), Gaps = 54/409 (13%)

Query: 104  EKWSKVRAERNSAREEGRQLRIKLEMAMKELSTLKKKQSLPPQKEALEANVTQDLKLPGF 163
            EK  K+R+   +   E  ++ +  E A K    L++ + +  Q E LEA + +  +    
Sbjct: 729  EKNEKIRSLETNINTEHEKICLAFEKAKK--IHLEQHKEMEKQIERLEAQLEKKDQQFKE 786

Query: 164  VEESCEHTDQFQLSSQMH-ESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLD 222
             E++     Q  +  Q H ES+   L + +   K++   K++ +     ++SEE      
Sbjct: 787  QEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEET----- 841

Query: 223  GVDLFNNGGSGNGETKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALE 282
                           K      A+ +  E  V  ++ L+ + ++F+K L K+ E    L+
Sbjct: 842  --------------IKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQ 887

Query: 283  KEIERLESALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKD 342
            KE+          K K   L+E+  +NV     L  Q     QE   N + E  +Q   +
Sbjct: 888  KEL----------KIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELED-TQTKLE 936

Query: 343  RVICELRAELERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSA 402
            + + +L  EL++ Q E+++E  ++   + E    E + +R K+      EL     ++  
Sbjct: 937  KQVSKLEQELQK-QRESSAEKLRKMEEKCESAAHEADLKRQKVI-----ELTGTARQV-- 988

Query: 403  NSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLR 462
                      +I++ +  +EL  ++     L R  +     L+  +  +DQ + E++K  
Sbjct: 989  ----------KIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKT 1038

Query: 463  LRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRHLQ 511
              V+EL++  +  E EL ++L +   L+  L   +  +  L++ LR LQ
Sbjct: 1039 NAVKELEKLQHSTETELTEALQKREVLETEL---QNAHGELKSTLRQLQ 1084



 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 93/454 (20%), Positives = 187/454 (41%), Gaps = 68/454 (14%)

Query: 72   ELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRI---KLE 128
            +L+ +++ E+   A Q++  M         ++E+ SK+  E    + +G    +   +L+
Sbjct: 972  DLKRQKVIELTGTARQVKIEMD-------QYKEELSKMEKEIMHLKRDGENKAMHLSQLD 1024

Query: 129  MAMKELST-LKKKQSLPPQKEAL----EANVTQDLKLPGFVEESCEHTD-QFQLSSQMHE 182
            M + +  T L+KK +   + E L    E  +T+ L+    +E   ++   + + + +  +
Sbjct: 1025 MILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQ 1084

Query: 183  SIREYLVKRQFSTKED-TNNKEQGVVIDSLKLS-EEMKPNLDGVDLFNNGGSGNGETKTG 240
             +R+ L K Q S +E  T  K+    +   K+  E+ K  L  +D               
Sbjct: 1085 ELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQ-------------- 1130

Query: 241  LRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYE 300
              LK  N  L+    +++ L + +          RE R  +E++I +LE  L        
Sbjct: 1131 -ALKERNWELKQRAAQVTHLDMTI----------REHRGEMEQKIIKLEGTL-------- 1171

Query: 301  ELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQ---- 356
               E     +KE +  +   ND++Q     ++E+       ++ I +L+ E+ER Q    
Sbjct: 1172 ---EKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMK 1228

Query: 357  -AENTSEWDKREILEREKQGLE--RENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQ 413
              E+  +  ++ I  + K+ ++  +E R  + QV+     L +       +Q    ++S 
Sbjct: 1229 EMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSS 1288

Query: 414  IDLQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLN 473
             +L++  Q           L  +  A+     H   R+   +AE+KKL   VE LK+  +
Sbjct: 1289 -ELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARM---QAEIKKLSAEVESLKEAYH 1344

Query: 474  QKEDELDDSLNQIRKLQRSLDEEKERNENLETEL 507
                E+        K + S D +K   + L  +L
Sbjct: 1345 M---EMISHQENHAKWKISADSQKSSVQQLNEQL 1375



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 98/419 (23%), Positives = 180/419 (42%), Gaps = 61/419 (14%)

Query: 103 REKWSKVRAERNSAREEGRQLRIKLEMAMKELSTLKKKQSLPPQKEALEANVTQDLKLPG 162
           REK +K+R +      +   L  K E    EL+  + K S+      LE+   Q   +P 
Sbjct: 235 REKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSM------LESAQQQAASVP- 287

Query: 163 FVEESCEHTDQFQLSSQMHESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLD 222
            +EE   + +  ++S+Q  + +RE   K + S K     KEQ     SL+ S+E    L 
Sbjct: 288 ILEEQIINLEA-EVSAQ-DKVLREAENKLEQSQKM-VIEKEQ-----SLQESKEECIKLK 339

Query: 223 GVDLFNNGGSGNGETKTGLRL-KAINLPLENEVTEISALQVH----LDEFQKILWKEREM 277
            VDL         +TK G R  +  N  L N      A Q +     ++ +K+  +E  +
Sbjct: 340 -VDLLE-------QTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEIL 391

Query: 278 R---TALEKEIERLESALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEE 334
               T  EKE +RL+    L+K + E LKE                  +++E + N KE+
Sbjct: 392 ERNLTNCEKENKRLQERCGLYKSELEILKEKLR---------------QLKEENNNGKEK 436

Query: 335 SKSQNSKDRVICELRAELERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEELL 394
            +    K+  +     E  +   +  SE + ++ + R+K  L  ENR LK++V    E L
Sbjct: 437 LRIMAVKNSEVMAQLTESRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQNERL 496

Query: 395 DKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQN 454
           D   +        + + S+++L+   + +  L         +   +  +++  +N+ D+ 
Sbjct: 497 DLCQQ--------EIESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRC 548

Query: 455 EAEVKKLRLRVEELKQGLNQKEDELDD-----SLNQIRKLQRSLDEEKERNE--NLETE 506
               +  +L + EL+  L  KE E+       + NQ+ +   + ++ +E ++  +LETE
Sbjct: 549 IGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETE 607



 Score = 33.5 bits (75), Expect = 0.48
 Identities = 32/162 (19%), Positives = 75/162 (46%), Gaps = 11/162 (6%)

Query: 356 QAENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKN----RLSANSQSPDFKM 411
           +AEN  E  ++ ++E+E+   E +   +K++V  +E+    K     R  A   + +   
Sbjct: 309 EAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAERQRNEALYNAEELSK 368

Query: 412 SQIDLQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQN----EAEVKKLRLRVEE 467
           +    ++K  E L    A  ++    + N+      N R+ +     ++E++ L+ ++ +
Sbjct: 369 AFQQYKKKVAEKLEKVQAEEEI---LERNLTNCEKENKRLQERCGLYKSELEILKEKLRQ 425

Query: 468 LKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRH 509
           LK+  N  +++L     +  ++   L E ++    LE+EL +
Sbjct: 426 LKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELEN 467


>gi|71061468 centromere protein E [Homo sapiens]
          Length = 2701

 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 106/471 (22%), Positives = 212/471 (45%), Gaps = 74/471 (15%)

Query: 101 NWREKWSKVRAERNSAREEGRQLRI-KLEMAMKELSTLKKKQSLPPQKEALEANVTQDLK 159
           N   + + +RA+ ++   +  QLR  K EM +K    LK+K  L  + EALE    +D +
Sbjct: 495 NIESELNSLRADYDNLVLDYEQLRTEKEEMELK----LKEKNDLD-EFEALERKTKKDQE 549

Query: 160 LPGFVEES-----CEHTDQFQLSSQMHESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLS 214
           +    E S      +H + +    +   S +  L++     KED   K Q   IDS KL 
Sbjct: 550 MQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLRE----KEDQIKKLQEY-IDSQKLE 604

Query: 215 E---EMKPNLDGVD--------LFNNGGSGNGETKTGLRLKAINLPLENEVTEISALQVH 263
               ++  +L+ ++        LF+         +    L++ NL L+ ++ E++     
Sbjct: 605 NIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQ 664

Query: 264 LDE----FQKILWKEREMRTALEKEIERLESALSLWKWKYEELKESK-PKNVKEFDILLG 318
           ++     +Q  L  +++M+  LEKE++   + ++    K   L + K PK++     L G
Sbjct: 665 MENDIQLYQSQLEAKKKMQVDLEKELQSAFNEIT----KLTSLIDGKVPKDLLCNLELEG 720

Query: 319 QHNDEMQELSGNIKEESKSQNSKDRVICELRA---ELERLQAENTSEWDKREILEREKQG 375
           +  D  +EL+  + EE+++   +  ++ EL++   E+ERL+ E   + ++  I+  EK  
Sbjct: 721 KITDLQKELNKEV-EENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDK 779

Query: 376 LERENRRLKIQVKEMEELLDK---------KNRLSANSQSPDFKMSQIDLQEK------- 419
           L  E    + +V+ + E + K          N  S + +  +FK   +D ++K       
Sbjct: 780 LFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEE 839

Query: 420 ----NQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQK 475
               NQE++NL     K +    A   EL++    + +   EV++    +E+LK+ L  +
Sbjct: 840 NERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENR 899

Query: 476 E--------------DELDDSLNQIRKLQRSLDEEKERNENLETELRHLQN 512
           +              ++L  +L +++ L +  D+ K+  E+L+ E   L++
Sbjct: 900 DSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKS 950



 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 100/426 (23%), Positives = 179/426 (42%), Gaps = 86/426 (20%)

Query: 99   TANWREKWSKVRAERNSAREEGRQLRIKLEMAMKELSTLKKKQSLPPQK--EALEA--NV 154
            T   +EK  +V+   N    E  QL+ +LE     L T++++++L  +K  + LE    +
Sbjct: 872  TQELQEKTREVQERLN----EMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTL 927

Query: 155  TQDLKLPGFVEESCEHTDQFQLSSQMHESIREYLVKRQFSTKEDTNN-----KEQGVVID 209
            TQ+      ++ES +  ++ QL S +H++     V     T+E   N     K+    I+
Sbjct: 928  TQEKDDLKQLQESLQ-IERDQLKSDIHDT-----VNMNIDTQEQLRNALESLKQHQETIN 981

Query: 210  SLK--LSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLENEVTEISALQVHLDEF 267
            +LK  +SEE+  NL   +         GETK   + K + +                D+ 
Sbjct: 982  TLKSKISEEVSRNLHMEE-------NTGETKDEFQQKMVGI----------------DKK 1018

Query: 268  QKILWKEREMRTALEKEIERLESALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQEL 327
            Q +  K  +  TA  K+ E +E    ++    E+          E   +L     E ++L
Sbjct: 1019 QDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEK---------NELQQMLESVIAEKEQL 1069

Query: 328  SGNIKEESKSQNSKDRVICELRAELERLQAENTSEWDKREILEREKQGLERENRRLKIQV 387
              ++KE  +        +  L  EL++ Q          EI+ +EK    ++   L    
Sbjct: 1070 KTDLKENIEMTIENQEELRLLGDELKKQQ----------EIVAQEKNHAIKKEGELS--- 1116

Query: 388  KEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAELTHA 447
            +  + L + + +L   SQ          LQEK Q+LLN+Q    ++    Q  I E+ + 
Sbjct: 1117 RTCDRLAEVEEKLKEKSQQ---------LQEKQQQLLNVQEEMSEM----QKKINEIENL 1163

Query: 448  NNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETEL 507
             N +   E  ++ +     EL Q LN+  +E+  S+ + RK+       KE  ++ ETE 
Sbjct: 1164 KNELKNKELTLEHMETERLELAQKLNENYEEVK-SITKERKVL------KELQKSFETER 1216

Query: 508  RHLQNW 513
             HL+ +
Sbjct: 1217 DHLRGY 1222



 Score = 60.1 bits (144), Expect = 5e-09
 Identities = 94/468 (20%), Positives = 215/468 (45%), Gaps = 51/468 (10%)

Query: 71   EELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMA 130
            E+  ++++ EV+ +  ++++         +  +   SK+    N  +E   +++I +   
Sbjct: 1533 EQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMI--- 1589

Query: 131  MKELSTLKKKQ-SLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIREYL- 188
             KE   +K+ Q +L  +++ L+ N  +   +   ++ES E   QF   + ++E+  +   
Sbjct: 1590 -KEKEEMKRVQEALQIERDQLKENTKE---IVAKMKESQEKEYQFLKMTAVNETQEKMCE 1645

Query: 189  ---VKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKA 245
               +K QF T++      + +  ++++L++ +  NL+ +             +  L+++ 
Sbjct: 1646 IEHLKEQFETQK---LNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVER 1702

Query: 246  INLP--LENEVT-------EISALQVHLDEFQKILWKEREMRTA-------LEKEIERLE 289
              L   L   +T       E+  + +HL E Q+ + K R + +        ++K++E   
Sbjct: 1703 DQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSN 1762

Query: 290  SALSLWKWKYEELKESKPKNVKE----FDILLGQHNDEMQELSGNIKEESKSQNSKDRVI 345
             AL     K +E       ++KE     D L G  +++  +LS N++++ ++ N+K    
Sbjct: 1763 DALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLS-NMQKDLENSNAK---- 1817

Query: 346  CELRAELERLQA-ENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSAN- 403
              L+ +++ L+A E+     K+++ E +K+  E E  +LK Q+K+    L K    + N 
Sbjct: 1818 --LQEKIQELKANEHQLITLKKDVNETQKKVSEME--QLKKQIKDQSLTLSKLEIENLNL 1873

Query: 404  SQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRL 463
            +Q     + ++    K ++ L       KL R       + T A +   Q E  +K  R+
Sbjct: 1874 AQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQE--LKTARM 1931

Query: 464  RVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRHLQ 511
              +E K+ +++  +++ +   QI  +Q+ LD+ K   + L+ +++ LQ
Sbjct: 1932 LSKEHKETVDKLREKISEKTIQISDIQKDLDKSK---DELQKKIQELQ 1976



 Score = 59.3 bits (142), Expect = 8e-09
 Identities = 84/417 (20%), Positives = 185/417 (44%), Gaps = 30/417 (7%)

Query: 116  AREEGRQLRI--KLEMAMKELSTL-KKKQSLPPQKEALEANVTQDLK------LPGFVEE 166
            AR E  +LR+  K + + +E+ +L K++ +L   KEALE    Q LK      L    E 
Sbjct: 1324 ARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQ-LKEHIRETLAKIQES 1382

Query: 167  SCEHTDQFQLSSQMHESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDL 226
              +      +  + +E+ +      QF  K+    +   + I+ L LS+ ++ + D  ++
Sbjct: 1383 QSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLR---IEIEMLGLSKRLQESHD--EM 1437

Query: 227  FNNGGSGNGETKTGLRLKAINLPLENEVTEISALQVHLDEFQKI----LWKEREMRTALE 282
             +     +   +    L++ +  L+  + EI A  +  +E  K+    L ++ E    L 
Sbjct: 1438 KSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELR 1497

Query: 283  KEIERLESALSLWKWKYEELKESKPKNVKEFDILLGQHN----DEMQELSGNIKEESKSQ 338
              +   E+ +S  + + E + +     ++E      Q N     E+QE    +K+  + +
Sbjct: 1498 VNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHR 1557

Query: 339  NSKDRVICELRAELERLQAENTSEWDKREILEREKQGLERENRRLKI---QVKEMEELLD 395
             +KD  +  + +++  L        ++ +I+ +EK+ ++R    L+I   Q+KE  + + 
Sbjct: 1558 KAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIV 1617

Query: 396  KKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNE 455
             K + S   +    KM+ ++  E  +++  ++H   +   Q + N+  +   N R+ Q  
Sbjct: 1618 AKMKESQEKEYQFLKMTAVN--ETQEKMCEIEHLKEQFETQ-KLNLENIETENIRLTQIL 1674

Query: 456  AEVKKLRLRVEELKQGLNQKEDELDDSLNQIRK-LQRSLDEEKERNENLETELRHLQ 511
             E  +    V + +  L   E+ L    +Q+++ L+ ++  + E+ E L+    HL+
Sbjct: 1675 HENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLK 1731



 Score = 49.7 bits (117), Expect = 6e-06
 Identities = 96/477 (20%), Positives = 196/477 (41%), Gaps = 57/477 (11%)

Query: 69   ICEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLE 128
            I E+L+ + LEEVK    + +   +          +  S +    N   +   QLR  LE
Sbjct: 913  ITEKLQ-QTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALE 971

Query: 129  MAMKELSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIREYL 188
                  S  + ++++   K  +   V+++L +    E + E  D+FQ      +  ++  
Sbjct: 972  ------SLKQHQETINTLKSKISEEVSRNLHME---ENTGETKDEFQQKMVGIDKKQDLE 1022

Query: 189  VKRQFSTKEDTNNKE----QGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLK 244
             K   +   D  + E    Q  +   ++   E++  L+ V       +   + KT L+ +
Sbjct: 1023 AKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVI------AEKEQLKTDLK-E 1075

Query: 245  AINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEI----ERLESALSLWKWKYE 300
             I + +EN+  E+  L   L + Q+I+ +E+      E E+    +RL       K K +
Sbjct: 1076 NIEMTIENQ-EELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQ 1134

Query: 301  ELKESKPK--NVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAE 358
            +L+E + +  NV+E    + +  +E++ L   +K +  +    +    EL  +L     E
Sbjct: 1135 QLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEE 1194

Query: 359  NTSEWDKREILEREKQGLERENRRLKIQVKEMEEL-LDKKNRLSANSQSPDFKMSQID-- 415
              S   +R++L+  ++  E E   L+  ++E+E   L  K  L             ID  
Sbjct: 1195 VKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDEL 1254

Query: 416  ---LQEKNQELLN---LQHAYYKLNRQYQA---------NIAELTHANNRVDQNEAEVKK 460
               + EK  +++N   L+ ++ KL  +            N+ E++     +++ E   ++
Sbjct: 1255 RRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQ 1314

Query: 461  ---------LRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELR 508
                      R+ +E L+  LN+K  E  + +  + K + +L   KE  E    +L+
Sbjct: 1315 STTKDSTTLARIEMERLR--LNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLK 1369



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 74/383 (19%), Positives = 153/383 (39%), Gaps = 61/383 (15%)

Query: 123  LRIKLEMAMKELSTLKKK-QSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMH 181
            L+  +EM ++    L+     L  Q+E +       +K  G +  +C+        +++ 
Sbjct: 1073 LKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRL------AEVE 1126

Query: 182  ESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGL 241
            E ++E   + Q   ++  N +E+           EM+  ++ ++   N            
Sbjct: 1127 EKLKEKSQQLQEKQQQLLNVQEE---------MSEMQKKINEIENLKN------------ 1165

Query: 242  RLKAINLPLENEVTEISALQVHLDEFQ---KILWKEREMRTALEKEIERLESALSLWKWK 298
             LK   L LE+  TE   L   L+E     K + KER++   L+K  E     L  +  +
Sbjct: 1166 ELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIRE 1225

Query: 299  YEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAE 358
             E       + +K   I L +H + + EL  ++ E++                    Q  
Sbjct: 1226 IEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKT-------------------AQII 1266

Query: 359  NTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQE 418
            NT + +K     +E+  +  E + L   VKE+ E  +  N L   ++    K S      
Sbjct: 1267 NTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDS------ 1320

Query: 419  KNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDE 478
                L  ++    +LN ++Q +  E+       D  +   + L ++ ++LK+ + +   +
Sbjct: 1321 --TTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAK 1378

Query: 479  LDDSLNQIRKLQRSLDEEKERNE 501
            + +S +   K ++SL+ +++ NE
Sbjct: 1379 IQESQS---KQEQSLNMKEKDNE 1398



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 97/473 (20%), Positives = 202/473 (42%), Gaps = 58/473 (12%)

Query: 69   ICEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLE 128
            I EELR+  +  +K +   ++K     S+ T    +K S ++ +  ++  + ++   +L+
Sbjct: 1772 IQEELRIAHMH-LKEQQETIDKLRGIVSEKT----DKLSNMQKDLENSNAKLQEKIQELK 1826

Query: 129  MAMKELSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIREYL 188
                +L TLKK  +   +K +    + + +K         E  +   L+ ++HE++ E  
Sbjct: 1827 ANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLE-IENLNLAQKLHENLEE-- 1883

Query: 189  VKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINL 248
            +K     +++    E+ + ++  +L E ++      DL         E KT   L   + 
Sbjct: 1884 MKSVMKERDNLRRVEETLKLERDQLKESLQET-KARDL-----EIQQELKTARMLSKEHK 1937

Query: 249  PLENEVTE-ISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELKESKP 307
               +++ E IS   + + + QK L K ++    L+K+I+ L+    L   + +E      
Sbjct: 1938 ETVDKLREKISEKTIQISDIQKDLDKSKD---ELQKKIQELQKK-ELQLLRVKEDVNMSH 1993

Query: 308  KNVKEFDILLGQHNDEMQELS------GNIKEESKSQNSKD--RVICELRAELERLQAEN 359
            K + E + L  Q   E Q LS       N +   K   S +  R++ + R EL R++   
Sbjct: 1994 KKINEMEQLKKQF--EAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESL 2051

Query: 360  TSEWDK-----REILEREKQ-------------GLERENRRLKIQVKEMEELLDKKNRLS 401
              E D+     RE++ R++Q             G +     L+ +   ++ELL + + + 
Sbjct: 2052 KMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMD 2111

Query: 402  ANSQSPDFKMSQIDLQ---EKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEV 458
             + +        +DL+   E  +EL     A   L      +I +L  AN R      E 
Sbjct: 2112 DHYEC--LNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSM---EF 2166

Query: 459  KKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRHLQ 511
             ++  +++ +   + + ++E  +S+N   K +    +E E+ + L  +++HLQ
Sbjct: 2167 HRIMKKLKYVLSYVTKIKEEQHESIN---KFEMDFIDEVEKQKELLIKIQHLQ 2216



 Score = 35.4 bits (80), Expect = 0.13
 Identities = 41/175 (23%), Positives = 71/175 (40%), Gaps = 22/175 (12%)

Query: 127  LEMAMKELSTLKKKQSL--PPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESI 184
            LE   + +  L+ K +L   P KE +E      +KL     E  ++  +F+      ++ 
Sbjct: 2432 LEKTKETIQVLQDKVALGAKPYKEEIE---DLKMKLVKIDLEKMKNAKEFEKEISATKAT 2488

Query: 185  REYLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLK 244
             EY  +     +E+    +Q    D+  +SE   P      L   GGSG  +    L LK
Sbjct: 2489 VEYQKEVIRLLRENLRRSQQAQ--DTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILK 2546

Query: 245  AINLPLENEVT--------------EISALQVHLDEFQKILWKEREMRTALEKEI 285
            + ++ LE E++              E+ +   HL    K  WKER ++    K++
Sbjct: 2547 SEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVK-TWKERTLKREAHKQV 2600



 Score = 31.2 bits (69), Expect = 2.4
 Identities = 62/285 (21%), Positives = 111/285 (38%), Gaps = 41/285 (14%)

Query: 121  RQLRIKLEMAMKELSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQF--QLSS 178
            + L+ K E   K   TLK   +   Q        TQD K P     + + T +   +L +
Sbjct: 2333 KSLKEKNEKLFKNYQTLKTSLASGAQVNP----TTQDNKNPHVTSRATQLTTEKIRELEN 2388

Query: 179  QMHESIREYLVK--------RQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNG 230
             +HE+    + K        ++     D   K Q  V +S K  E+ K  +  +      
Sbjct: 2389 SLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVL------ 2442

Query: 231  GSGNGETKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLES 290
                 + K  L  K    P + E+ ++    V +D  +    KE       EKEI   ++
Sbjct: 2443 -----QDKVALGAK----PYKEEIEDLKMKLVKIDLEKMKNAKE------FEKEISATKA 2487

Query: 291  ALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKS---QNSKDRVICE 347
             +   K     L+E+  ++ +  D  +   + + Q  +  +     S   QN+K  +   
Sbjct: 2488 TVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALI--- 2544

Query: 348  LRAELERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEE 392
            L++E  RL+ E +    + E L ++K  L   N+ L  +VK  +E
Sbjct: 2545 LKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKE 2589



 Score = 30.4 bits (67), Expect = 4.0
 Identities = 42/216 (19%), Positives = 91/216 (42%), Gaps = 37/216 (17%)

Query: 331 IKEESKSQNSKDRVICELRA-----ELERLQAENTSEWDK-------------------R 366
           I + S   N+K R+IC +        L  LQ  +T+++ K                   +
Sbjct: 291 ILQNSLGGNAKTRIICTITPVSFDETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRK 350

Query: 367 EILEREKQ--GLERENRRLKIQVKEMEELLDKKNRLSA-------NSQSPDFKMSQIDLQ 417
           EI++ +KQ   +  E R   ++  ++ +LL++K+ L         N        S + LQ
Sbjct: 351 EIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQ 410

Query: 418 E--KNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQK 475
           +  K +    +     K+N+   +N A+  +    +     ++    LR  E+ + +  +
Sbjct: 411 QELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLR--EIDESVCSE 468

Query: 476 EDELDDSLNQIRKLQRSLDEEKERNENLETELRHLQ 511
            D   ++L+ + +++ +   +    EN+E+EL  L+
Sbjct: 469 SDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLR 504


>gi|55770834 centromere protein F [Homo sapiens]
          Length = 3114

 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 112/474 (23%), Positives = 195/474 (41%), Gaps = 87/474 (18%)

Query: 101  NWREKW-------SKVRAERNSAREEGRQLRIKLEMAMKELSTLK-----KKQSLPPQKE 148
            +W+E++       S++R+E+ S   E   L   LE+   E   L+     K++ +   +E
Sbjct: 1892 SWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEE 1951

Query: 149  ALEANVTQDLKLPGFVEESCEHTDQF-QLSSQMHESIREYLVKRQFSTKEDTNNKEQGVV 207
             L    ++  +L G ++   + T    QLS +M E  +E                 Q   
Sbjct: 1952 ELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQEL-------------ESHQSEC 1998

Query: 208  IDSLKLSE-EMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLENEVTEISALQVHLDE 266
            +  ++++E E+K   + +   ++  S   + KT L+ K  +  LE +   +S  +  L+ 
Sbjct: 1999 LHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQS--LEKDSQALSLTKCELEN 2056

Query: 267  FQKILWKEREMRTALEKEIERLESALSLWKWKYEELKESKPKNVK-----EFDILLGQHN 321
                L KE+E+   L KE E L++ LS  +  YE+L  SK          EF + L    
Sbjct: 2057 QIAQLNKEKEL---LVKESESLQARLS--ESDYEKLNVSKALEAALVEKGEFALRLSSTQ 2111

Query: 322  DEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWDKREILEREKQG------ 375
            +E+ +L   I++      + ++    +  +L+  + EN S  DK E LERE Q       
Sbjct: 2112 EEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQE 2171

Query: 376  ---LERENRR-----LKIQVKEMEE-----------LLDKKNRLSANSQSPDFKMSQID- 415
               L+ EN +     LK Q++EM             L  +K  L+   Q    ++S++D 
Sbjct: 2172 LVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDK 2231

Query: 416  --------LQEKNQELLNLQHAYYKLNRQYQANIAELTHA--------------NNRVDQ 453
                    L+EK Q  + ++          Q  + EL  A                 +D 
Sbjct: 2232 LLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDP 2291

Query: 454  NEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETEL 507
               E  +LR  +E+L+  L   E +    L Q+++ +   D  K R ENLE EL
Sbjct: 2292 PIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLEREL 2345



 Score = 66.6 bits (161), Expect = 5e-11
 Identities = 93/454 (20%), Positives = 190/454 (41%), Gaps = 46/454 (10%)

Query: 77   ELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAMKELST 136
            E E ++++   +E  ++     +  + E+   +  +R +   E R L   L+    E+ T
Sbjct: 636  EKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVET 695

Query: 137  -------LKKKQSLPPQK--EALEANVTQDLKLPGFVEE--------SCEHTDQFQLSSQ 179
                   L++K     QK  + +E    +  +L G VE+        S E  D+ +    
Sbjct: 696  QKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQD 755

Query: 180  MH---ESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGE 236
            +H   ES+R+ L  +  S   + +++   +  D          N+ G       GS   E
Sbjct: 756  LHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQ-----GSMPSE 810

Query: 237  TKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWK 296
             ++  RL+A   P  + +     LQ  +D  +  L  +++M + L+K+ E L        
Sbjct: 811  -RSECRLEADQSPKNSAI-----LQNRVDSLEFSLESQKQMNSDLQKQCEELV------- 857

Query: 297  WKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQ 356
                ++K    +N+ + + +   H   + E S  I +  +  ++   V+ E  + LE  +
Sbjct: 858  ----QIKGEIEENLMKAEQM---HQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKE 910

Query: 357  AENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDL 416
             E     DK E  + E Q L++ N  L+  +KE++ LL +   L     S    +++ ++
Sbjct: 911  KELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQ-LLSETLSLEKKEMSSIISLNKREI 969

Query: 417  QEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKE 476
            +E  QE   L+     LN++    I +     N +D+ E  + +L  + ++ K  L Q+ 
Sbjct: 970  EELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRC 1029

Query: 477  DELDDSLNQIRKLQRSLDEEKERNENLETELRHL 510
            +E  ++   + +  ++  E+  + E L  E   L
Sbjct: 1030 EETGNAYEDLSQKYKAAQEKNSKLECLLNECTSL 1063



 Score = 59.3 bits (142), Expect = 8e-09
 Identities = 90/419 (21%), Positives = 170/419 (40%), Gaps = 52/419 (12%)

Query: 105 KWSKVRAERNSAREEGRQLRIKLEMAMKELSTLKKKQSLPPQKEALEANVTQDLKLPGFV 164
           K+  ++ + N   EE    R +LE  +K L   K  Q+LP Q      ++ +        
Sbjct: 163 KYEDLKEKYNKEVEE----RKRLEAEVKALQAKKASQTLP-QATMNHRDIARHQASSSVF 217

Query: 165 EESCEHTDQFQLSSQMHESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGV 224
               E T     S+     IR       FS +++       + I     +     N    
Sbjct: 218 SWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSP 277

Query: 225 DLFNNGGSGNGETKTGLRLKAINLPLENEVTEISA-LQVHLDEFQKILWKEREMRTALEK 283
            L +             +LKA N  L N++ E+   LQ H  E +  + K +E++  LEK
Sbjct: 278 HLLD-------------QLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEK 324

Query: 284 -EIERLESALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKD 342
            ++E +E    L K + E ++ +      ++D    ++    Q+L    ++ S  + + +
Sbjct: 325 AKVELIEKEKVLNKCRDELVRTTA-----QYDQASTKYTALEQKLKKLTEDLSCQRQNAE 379

Query: 343 RVICELRAELERLQAENTSEWDKREILEREKQGLERENRRLKIQV-KEMEELLDKKNRLS 401
              C L  +++  + E   E  +++   R  Q L++E  ++K ++ +E+++  +  N L 
Sbjct: 380 SARCSLEQKIKEKEKEFQEELSRQQ---RSFQTLDQECIQMKARLTQELQQAKNMHNVLQ 436

Query: 402 ANSQSPDFKMSQID--LQEKNQELLNLQHAYYKLN---RQYQANIAELTHANNRV----D 452
           A          Q++  L+E  Q+L   + A+        + + ++ E+   NN +    +
Sbjct: 437 AELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSE 496

Query: 453 QNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRHLQ 511
           Q   EV  L   ++ +KQ LNQ               Q   +E K +N + ET LR LQ
Sbjct: 497 QKAREVCHLEAELKNIKQCLNQS--------------QNFAEEMKAKNTSQETMLRDLQ 541



 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 88/417 (21%), Positives = 175/417 (41%), Gaps = 79/417 (18%)

Query: 105  KWSKVRAERNSAREEGRQLR-IKLEMAMKELSTLKKKQSLPPQKEALEA---NVTQDLKL 160
            K S+V  E    +E+  +LR + +E+  K      K  SL    E L++   N+  +L+L
Sbjct: 2540 KLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELEL 2599

Query: 161  P-----GFVEESCEHT-DQFQLSSQMHESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLS 214
                   FVE+  + T  + +L  +MHE     + ++    +E+ + ++  +  +   L 
Sbjct: 2600 TKMDKMSFVEKVNKMTAKETELQREMHE-----MAQKTAELQEELSGEKNRLAGELQLLL 2654

Query: 215  EEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWKE 274
            EE+K + D +         N E K     K+++   +++V +   ++  + E+Q  L + 
Sbjct: 2655 EEIKSSKDQLKELT---LENSELK-----KSLDCMHKDQVEKEGKVREEIAEYQLRLHEA 2706

Query: 275  REMRTALEKEIER-LESALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKE 333
             +   AL  +  +  E  +  ++ K    +E       E D+L                 
Sbjct: 2707 EKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLL----------------- 2749

Query: 334  ESKSQNSKDRVICELRAELERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEEL 393
                ++SK+ +   L+A  + L+    ++ D  + + + K+  ER   ++K+ +K  ++L
Sbjct: 2750 ----KSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQL 2805

Query: 394  LDKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQ 453
             ++K  L                    +EL  LQ A  K            T  + +VD+
Sbjct: 2806 EEEKEILQ-------------------KELSQLQAAQEKQKTG--------TVMDTKVDE 2838

Query: 454  NEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRHL 510
               E+K       ELK+ L +K  E D+ L++   L  S ++ ++  E LET++ HL
Sbjct: 2839 LTTEIK-------ELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHL 2888



 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 85/441 (19%), Positives = 175/441 (39%), Gaps = 54/441 (12%)

Query: 108 KVRAERNSAREEGRQLRIKLEMAMKELS-TLKKKQSLPPQKEALEANVTQDLK-LPGFVE 165
           +++A+    R +  +L ++L+   KE+   + K Q L  Q E  +  + +  K L    +
Sbjct: 282 QLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRD 341

Query: 166 ESCEHTDQFQLSSQMHESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVD 225
           E    T Q+  +S  + ++ + L K          N E        K+ E+ K   +  +
Sbjct: 342 ELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQE--E 399

Query: 226 LFNNGGSGNGETKTGLRLKA-INLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKE 284
           L     S     +  +++KA +   L+      + LQ  LD+   +  +        +++
Sbjct: 400 LSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQK 459

Query: 285 IERLESALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQEL----------------S 328
           + R E A    + K  EL+ S  +  KE ++L      + +E+                S
Sbjct: 460 LCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQS 519

Query: 329 GNIKEESKSQN-SKDRVICELRAELERLQAENTSEWDKREILEREKQG------------ 375
            N  EE K++N S++ ++ +L+ ++ + +   T E  K  + + EKQ             
Sbjct: 520 QNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREH 579

Query: 376 -----------LERENRRL----KIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKN 420
                       E+E++ L    +++ KE EEL ++K   S      +  ++Q++     
Sbjct: 580 HIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQME----- 634

Query: 421 QELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELD 480
            E  NLQ     L    +    +    N RV   E + + L + +  L   L+ K  E++
Sbjct: 635 SEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVE 694

Query: 481 DSLNQIRKLQRSLDEEKERNE 501
                  +LQ+  +   ++++
Sbjct: 695 TQKLAYMELQQKAEFSDQKHQ 715



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 104/493 (21%), Positives = 192/493 (38%), Gaps = 98/493 (19%)

Query: 71  EELRLRELEEVKARAAQMEKTMRWWSD----CTANW----------REKWSKVRAERNSA 116
           +EL+L +LE+ K    + EK +    D     TA +           +K  K+  + +  
Sbjct: 316 QELQL-QLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQ 374

Query: 117 REEGRQLRIKLEMAMKE--------LSTLKKK-QSLPPQKEALEANVTQDLK-------- 159
           R+     R  LE  +KE        LS  ++  Q+L  +   ++A +TQ+L+        
Sbjct: 375 RQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNV 434

Query: 160 ------------------LPGFVEESCEHTDQFQLSSQMHESIR---EYLVKRQFSTKED 198
                             L  F ++ C     FQ S      +R   E + K     K  
Sbjct: 435 LQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSH 494

Query: 199 TNNKEQGV-------------VIDSLKLSEEMKP-NLDGVDLFNNGGSGNGETKTGLRLK 244
           +  K + V             +  S   +EEMK  N     +  +      + +  L L+
Sbjct: 495 SEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLE 554

Query: 245 AINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELKE 304
            + L + +   +    Q  L + +  + +  +  +  EKE + L SAL L K +YEELKE
Sbjct: 555 KLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKE 614

Query: 305 SKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWD 364
            K         L      E ++L   ++ E ++  SK   I  L   L+  Q ++    +
Sbjct: 615 EK--------TLFSCWKSENEKLLTQMESEKENLQSK---INHLETCLKTQQIKSHEYNE 663

Query: 365 KREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEK----- 419
           +   LE     ++REN  L ++++ +  +LD K+ +   +Q    K++ ++LQ+K     
Sbjct: 664 RVRTLE-----MDREN--LSVEIRNLHNVLDSKS-VEVETQ----KLAYMELQQKAEFSD 711

Query: 420 ---NQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKE 476
               +E+ N+     +L  Q +    +L   +N +   +   + L    E L+  L  K+
Sbjct: 712 QKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKD 771

Query: 477 DELDDSLNQIRKL 489
             L  + +  R L
Sbjct: 772 ASLVTNEDHQRSL 784



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 61/284 (21%), Positives = 127/284 (44%), Gaps = 30/284 (10%)

Query: 250  LENEVTEISALQVHLDEFQKILWKE-----REMRTALEKEIERLESALSLWKWKYEELKE 304
            L NE+ E+ + ++HL E Q +   E      ++   L+KE   L   L  +   ++EL +
Sbjct: 1800 LLNEMKELDS-KLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQ 1858

Query: 305  S-KPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEW 363
              +       D+ +       +++  N+ + + S   K+R + ++  EL R+++E  S  
Sbjct: 1859 RVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSW--KERFL-DVENELSRIRSEKASIE 1915

Query: 364  DKR-------EILEREKQGLERENRRLKIQVKEMEELLD----KKNRLSANSQSPDFKMS 412
             +        E+++ EK  LE++N   +  +  +EE L     ++N+L     +   K +
Sbjct: 1916 HEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTT 1975

Query: 413  QID-----LQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEE 467
             +D     ++EK QEL + Q       +  +A + E T     +  + +E+ K +  ++E
Sbjct: 1976 ALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQE 2035

Query: 468  LKQGLNQKEDELD----DSLNQIRKLQRSLDEEKERNENLETEL 507
              Q L +    L     +  NQI +L +  +   + +E+L+  L
Sbjct: 2036 KLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARL 2079



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 85/400 (21%), Positives = 168/400 (42%), Gaps = 73/400 (18%)

Query: 139  KKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIREYLVKRQFSTKED 198
            K+Q+L  Q E LE    Q L+  G  E      +   L S ++  I+E    +Q   K+D
Sbjct: 2467 KEQNLSSQVECLELEKAQLLQ--GLDEAK---NNYIVLQSSVNGLIQEVEDGKQKLEKKD 2521

Query: 199  TNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLENEVTEIS 258
               +E   + + ++  E++   L  V+     G      +  L L+ + + LE ++  + 
Sbjct: 2522 ---EEISRLKNQIQDQEQLVSKLSQVE-----GEHQLWKEQNLELRNLTVELEQKIQVLQ 2573

Query: 259  ALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKW-KYEELKESKPKNVKEFDILL 317
            +    L +  ++L          +   + LE+ L L K  K   +++      KE ++  
Sbjct: 2574 SKNASLQDTLEVL----------QSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQR 2623

Query: 318  GQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWDKREILEREKQGLE 377
              H  EM + +  ++EE   +  K+R+  EL+  LE +++       K ++ E     L 
Sbjct: 2624 EMH--EMAQKTAELQEELSGE--KNRLAGELQLLLEEIKSS------KDQLKE-----LT 2668

Query: 378  RENRRLKIQVKEM-EELLDKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQ 436
             EN  LK  +  M ++ ++K+ ++    +  ++++   + ++K+Q LL         N+Q
Sbjct: 2669 LENSELKKSLDCMHKDQVEKEGKV--REEIAEYQLRLHEAEKKHQALL------LDTNKQ 2720

Query: 437  YQANIA----ELTHANNRVDQNEAEVKKLRLRVEELKQGL-------------------- 472
            Y+  I     +LT     +   + E+  L+   EEL   L                    
Sbjct: 2721 YEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKY 2780

Query: 473  -NQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRHLQ 511
             NQ + E + +  +++ L +S  + +E  E L+ EL  LQ
Sbjct: 2781 VNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQ 2820



 Score = 39.3 bits (90), Expect = 0.009
 Identities = 49/233 (21%), Positives = 90/233 (38%), Gaps = 64/233 (27%)

Query: 297 WKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQ 356
           W  EE KE  P    +          ++QEL G + +  K +  +       + +L+ L+
Sbjct: 3   WALEEWKEGLPTRALQ----------KIQELEGQLDKLKKEKQQR-------QFQLDSLE 45

Query: 357 AENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDL 416
           A    +  K E  + E   L+REN+RL   ++  E L   K ++S   Q    K SQ++ 
Sbjct: 46  AALQKQKQKVENEKTEGTNLKRENQRL---MEICESLEKTKQKISHELQ---VKESQVNF 99

Query: 417 QEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKE 476
           QE                        +L     ++++ E E+K+ +  +E  +Q     +
Sbjct: 100 QE-----------------------GQLNSGKKQIEKLEQELKRCKSELERSQQAAQSAD 136

Query: 477 DELDD------------------SLNQIRKLQRSLDEEKERNENLETELRHLQ 511
             L+                   S ++   L+   ++E E  + LE E++ LQ
Sbjct: 137 VSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQ 189



 Score = 37.4 bits (85), Expect = 0.033
 Identities = 48/198 (24%), Positives = 81/198 (40%), Gaps = 17/198 (8%)

Query: 319  QHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWDKREILEREKQGLER 378
            +   +M  LS      S +Q S D V C        LQ EN +   ++E      +G+E 
Sbjct: 1501 EQTGDMSLLSNLEGAVSANQCSVDEVFCS------SLQEENLT---RKETPSAPAKGVEE 1551

Query: 379  ENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQ 438
                 ++  + +E+L +K             ++ Q+ L  + QEL  L+  Y   N Q+Q
Sbjct: 1552 LESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQL-LSSERQELDCLRKQYLSENEQWQ 1610

Query: 439  ANIAELT---HANNRVDQNEAEVKKLRLRVEELK-QGLNQKEDEL--DDSLNQIRKLQRS 492
              +  +T    +    ++ + E   L L V  L+ QGL+     L   D+ + I+    S
Sbjct: 1611 QKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNES 1670

Query: 493  LDEEKER-NENLETELRH 509
             D  KE  +E  E   +H
Sbjct: 1671 CDISKEHTSETTERTPKH 1688



 Score = 31.2 bits (69), Expect = 2.4
 Identities = 34/152 (22%), Positives = 71/152 (46%), Gaps = 15/152 (9%)

Query: 278  RTALEKEIERLESALSLWKWKYEELKESKPKNVKEFDILLGQH---NDEMQELSGNIKEE 334
            R +LEK  E++ES   +   + +EL++      +E D L  Q+   N++ Q+   ++  E
Sbjct: 1560 RQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLE 1619

Query: 335  SKSQNSKDRVICE---LRAELERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEME 391
             +S+ + ++   E   L  E+ RLQ +        ++  R   G++ E+    IQ +   
Sbjct: 1620 MESKLAAEKKQTEQLSLELEVARLQLQGL------DLSSRSLLGIDTED---AIQGRNES 1670

Query: 392  ELLDKKNRLSANSQSPDFKMSQIDLQEKNQEL 423
              + K++      ++P   + QI  ++  Q+L
Sbjct: 1671 CDISKEHTSETTERTPKHDVHQICDKDAQQDL 1702


>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
           sapiens]
          Length = 1843

 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 102/469 (21%), Positives = 197/469 (42%), Gaps = 77/469 (16%)

Query: 73  LRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAMK 132
           LR R     +AR   +EK  +   +       K SK+  E+   ++E    + K E A +
Sbjct: 570 LRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEE 629

Query: 133 ---ELSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIREYLV 189
              EL  L+K+  L  QK+     +T + K+    +E+ E   + +   +  +S +    
Sbjct: 630 LENELHHLEKENELL-QKKITNLKITCE-KIEALEQENSELERENRKLKKTLDSFKNLTF 687

Query: 190 KRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLP 249
           + +   KE++   E+ +         E++ N++ +   +              +K   L 
Sbjct: 688 QLESLEKENSQLDEENL---------ELRRNVESLKCAS--------------MKMAQLQ 724

Query: 250 LENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLE---SALSLWKWKYEELKESK 306
           LEN+          L+  ++ L K  E+  A  K+ ERLE     L +   + ++  E+ 
Sbjct: 725 LENK---------ELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENS 775

Query: 307 PKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWDKR 366
            K +++ +  L     E Q L  N++E   S              LE+L+ EN S   + 
Sbjct: 776 NKKIQQLESELQDLEMENQTLQKNLEELKISSK-----------RLEQLEKENKSLEQET 824

Query: 367 EILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQ------------I 414
             LE++K+ LE+EN+RL+ Q +  +  L++ N    N +  +  +S+             
Sbjct: 825 SQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLK 884

Query: 415 DLQEKNQELLNLQHAYYK----LNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQ 470
           +L+++N+EL+       K    L     +   +    NN +++   E++K+ L     K+
Sbjct: 885 ELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLN----KE 940

Query: 471 GLNQKEDELDDSLNQIRK------LQRSLDEEKERNENLETELRHLQNW 513
            L   E   DDS  ++ +      L++SL+ ++E+   LE  L    N+
Sbjct: 941 RLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNY 989



 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 105/480 (21%), Positives = 201/480 (41%), Gaps = 52/480 (10%)

Query: 64   TNKWDICEELRLRELE--EVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGR 121
            TN    CE++   E E  E++    +++KT+    D   N   +   +  E +   EE  
Sbjct: 649  TNLKITCEKIEALEQENSELERENRKLKKTL----DSFKNLTFQLESLEKENSQLDEENL 704

Query: 122  QLRIKLEMAMKELSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMH 181
            +LR  +E    + +++K  Q     KE LE+   Q  K    ++ S + T++ ++S Q  
Sbjct: 705  ELRRNVESL--KCASMKMAQLQLENKE-LESEKEQLKKGLELLKASFKKTERLEVSYQGL 761

Query: 182  ESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLSEE---MKPNLDGVDLFNNGGSGNGETK 238
            +   + L K    T E++N K Q +  +   L  E   ++ NL+ + +          +K
Sbjct: 762  DIENQRLQK----TLENSNKKIQQLESELQDLEMENQTLQKNLEELKI---------SSK 808

Query: 239  TGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTA-----------LEKEIER 287
               +L+  N  LE E +++   +  L++  K L ++ E++             LEKE + 
Sbjct: 809  RLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKT 868

Query: 288  LESALSLWKWKYEELKESKPKN---VKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRV 344
            L   + ++K     LKE + +N   VK   I +       ++L     +  +  N  +++
Sbjct: 869  LSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKL 928

Query: 345  ICELRA---ELERLQAENTSEWDKR-EILERE-----KQGLERENRRLKIQVKEMEELLD 395
              EL       ERL  +  S  D R ++LE +     K+ LE +  ++      +EE  +
Sbjct: 929  THELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTN 988

Query: 396  KKNRLSANSQSPDFKMSQIDLQEKNQELLN----LQHAYYKLNRQYQANIAELTHANNRV 451
               +L    ++       +  ++  + ++     +     K  R+ Q    EL    +R+
Sbjct: 989  YNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRL 1048

Query: 452  DQNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRHLQ 511
             + E     L+   + LK  L Q E + ++   QI  LQR     +E+N  L+T+   LQ
Sbjct: 1049 IEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQ 1108



 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 82/368 (22%), Positives = 162/368 (44%), Gaps = 38/368 (10%)

Query: 65   NKWDICEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLR 124
            NKW+   +   REL +VK R  ++E+                + ++AE+ + + + +QL 
Sbjct: 1028 NKWERESQETTRELLKVKDRLIEVERNN--------------ATLQAEKQALKTQLKQLE 1073

Query: 125  IKLEMAMKELSTLKKKQ-SLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQ---- 179
             +      ++  L+++  SL  Q   L+   TQ+ KL   VE S  ++    L +Q    
Sbjct: 1074 TQNNNLQAQILALQRQTVSLQEQNTTLQ---TQNAKLQ--VENSTLNSQSTSLMNQNAQL 1128

Query: 180  -MHESIREYLVKRQFSTKEDTNNKEQGVVID--SLKLSEEMKPNLDGVDLFNNGGSGNGE 236
             + +S  E   +     +ED  +    ++ D   L+L  E + + +   L +  G+    
Sbjct: 1129 LIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQAS-EYESLISKHGTLKSA 1187

Query: 237  TKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWK 296
             K    L+  +  LE+   ++   +  L++ +K+L  E+E      K  E + +      
Sbjct: 1188 HKN---LEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLC 1244

Query: 297  WKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQ 356
             + + L  +  + +KE ++L   H + ++ L  N K E   Q   +    +L+ + ++L 
Sbjct: 1245 GENDRLNHTYSQLLKETEVLQTDHKN-LKSLLNNSKLE---QTRLEAEFSKLKEQYQQLD 1300

Query: 357  AENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPD-FKMSQID 415
              +T   ++ E+L + K  LE ENR L  Q++ +  +L  +  L  N +S D F + Q  
Sbjct: 1301 ITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTL--MLQNRTLLEQNMESKDLFHVEQRQ 1358

Query: 416  LQEKNQEL 423
              +K  EL
Sbjct: 1359 YIDKLNEL 1366



 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 90/415 (21%), Positives = 167/415 (40%), Gaps = 69/415 (16%)

Query: 104  EKWSKVRAERNSAREEGRQLRIKLEMAMKELSTLKKKQSLPPQKEALEANVTQDLKLPGF 163
            EK + + A    +    +QLR       +EL T+KK      Q++  E  V     + G 
Sbjct: 974  EKIAALEARLEESTNYNQQLR-------QELKTVKKNYEALKQRQDEERMVQSSPPISG- 1025

Query: 164  VEESCEHTDQFQLSSQMHESIREYLVKRQFSTKEDTNNK----EQGVVIDSLKLSEEMKP 219
                    ++++  SQ  E+ RE L  +    + + NN     E+  +   LK  E    
Sbjct: 1026 ------EDNKWERESQ--ETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNN 1077

Query: 220  NLDGVDL-FNNGGSGNGETKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMR 278
            NL    L          E  T L+ +   L +EN      +  + +++  ++L ++  + 
Sbjct: 1078 NLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSL-MNQNAQLLIQQSSLE 1136

Query: 279  TALEKEIERLESALSLWKW---KYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEES 335
               E  I+  E   SL+      +E+L+    +   E++ L+ +H        G +K   
Sbjct: 1137 NENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKH--------GTLKSAH 1188

Query: 336  KSQNSKDRVICELRAELERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLD 395
            K+                 L+ E+    D+   L ++K  LE   + LK++ ++M  LL+
Sbjct: 1189 KN-----------------LEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKM--LLE 1229

Query: 396  KKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNE 455
             KN     + + ++K     L  +N  L    H Y +L +  +  + +  H N +   N 
Sbjct: 1230 NKNH---ETVAAEYKK----LCGENDRL---NHTYSQLLK--ETEVLQTDHKNLKSLLNN 1277

Query: 456  AEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRHL 510
            +++++ RL  E  K  L ++  +LD +     KL    +   +   NLE E RHL
Sbjct: 1278 SKLEQTRLEAEFSK--LKEQYQQLDITST---KLNNQCELLSQLKGNLEEENRHL 1327



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 84/413 (20%), Positives = 166/413 (40%), Gaps = 32/413 (7%)

Query: 117 REEGRQLRIKLEMAMKE----LSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTD 172
           ++E  Q+ I+L+   +E    LS  +  +    + +AL     +  KL   V    E   
Sbjct: 278 KQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLH 337

Query: 173 QFQLSSQMHESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGS 232
             +      E ++E   +    TK    ++ +G    S KL E  K NL      ++   
Sbjct: 338 DIEFYKARVEELKEDN-QVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDM-- 394

Query: 233 GNGETKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWK-EREMRTA---------LE 282
              E +  +  K I   +E  +T   A +  +DE   + W+ E+  RT+         L 
Sbjct: 395 ---EMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLG 451

Query: 283 KEIERLESALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKD 342
            E+  L S+  L   K E   +S  K V+E    +        ++   +K E ++Q    
Sbjct: 452 HEVNELTSSRLL---KLEMENQSLTKTVEELRTTVDSVEGNASKI---LKMEKENQRLSK 505

Query: 343 RV-ICELRAELERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLS 401
           +V I E     E+   +N     K   L +EK  LE+    L+   +   ++L+++N   
Sbjct: 506 KVEILENEIVQEKQSLQNCQNLSKD--LMKEKAQLEKTIETLRENSERQIKILEQENEHL 563

Query: 402 ANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKL 461
             + S   + SQI  + + +++       ++  ++  + ++++     ++ +     K+ 
Sbjct: 564 NQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEK 623

Query: 462 RLRVEELKQGLNQKEDE---LDDSLNQIRKLQRSLDEEKERNENLETELRHLQ 511
             R EEL+  L+  E E   L   +  ++     ++  ++ N  LE E R L+
Sbjct: 624 GERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLK 676



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 59/260 (22%), Positives = 117/260 (45%), Gaps = 26/260 (10%)

Query: 273 KEREMRTALEKEIERLESALSLWKWKYEELKESKPKNVKEFDILLG--QHNDEMQELSGN 330
           K R +R  LE++ E+L       +    ELK  + +N+           + DE+  L   
Sbjct: 259 KIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREK 318

Query: 331 I----KEESKSQNSKDRV--ICELRAELERLQAENTSEWDKREILEREKQG--------- 375
                K ES+    K+R+  I   +A +E L+ +N    + + +LE + +G         
Sbjct: 319 AVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLH 378

Query: 376 -LERENRRLKIQVK--EMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYYK 432
            LE+EN +LK ++   EME  +D+K       ++   +M+Q   ++   E L+L     +
Sbjct: 379 ELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQ---KQSMDESLHLGWELEQ 435

Query: 433 LNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRS 492
           ++R  + + A      + V  NE    +L L++E   Q L +  +EL  +++ +      
Sbjct: 436 ISRTSELSEAPQKSLGHEV--NELTSSRL-LKLEMENQSLTKTVEELRTTVDSVEGNASK 492

Query: 493 LDEEKERNENLETELRHLQN 512
           + + ++ N+ L  ++  L+N
Sbjct: 493 ILKMEKENQRLSKKVEILEN 512


>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
           sapiens]
          Length = 1870

 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 101/466 (21%), Positives = 196/466 (42%), Gaps = 72/466 (15%)

Query: 73  LRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAMK 132
           LR R     +AR   +EK  +   +       K SK+  E+   ++E    + K E A +
Sbjct: 570 LRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEE 629

Query: 133 ---ELSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIREYLV 189
              EL  L+K+  L  QK+     +T + K+    +E+ E   + +   +  +S +    
Sbjct: 630 LENELHHLEKENELL-QKKITNLKITCE-KIEALEQENSELERENRKLKKTLDSFKNLTF 687

Query: 190 KRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLP 249
           + +   KE++   E+ +         E++ N++ +   +              +K   L 
Sbjct: 688 QLESLEKENSQLDEENL---------ELRRNVESLKCAS--------------MKMAQLQ 724

Query: 250 LENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLE---SALSLWKWKYEELKESK 306
           LEN+          L+  ++ L K  E+  A  K+ ERLE     L +   + ++  E+ 
Sbjct: 725 LENK---------ELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENS 775

Query: 307 PKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWDKR 366
            K +++ +  L     E Q L  N++E   S              LE+L+ EN S   + 
Sbjct: 776 NKKIQQLESELQDLEMENQTLQKNLEELKISSK-----------RLEQLEKENKSLEQET 824

Query: 367 EILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQ------------I 414
             LE++K+ LE+EN+RL+ Q +  +  L++ N    N +  +  +S+             
Sbjct: 825 SQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLK 884

Query: 415 DLQEKNQELLNLQHAYYK----LNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEEL-- 468
           +L+++N+EL+       K    L     +   +    NN +++   E++K+ L  E L  
Sbjct: 885 ELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLH 944

Query: 469 -KQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRHLQNW 513
            +Q  + +   L+  L     L++SL+ ++E+   LE  L    N+
Sbjct: 945 DEQSTDDRYKLLESKLES--TLKKSLEIKEEKIAALEARLEESTNY 988



 Score = 63.2 bits (152), Expect = 6e-10
 Identities = 104/479 (21%), Positives = 201/479 (41%), Gaps = 51/479 (10%)

Query: 64   TNKWDICEELRLRELE--EVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGR 121
            TN    CE++   E E  E++    +++KT+    D   N   +   +  E +   EE  
Sbjct: 649  TNLKITCEKIEALEQENSELERENRKLKKTL----DSFKNLTFQLESLEKENSQLDEENL 704

Query: 122  QLRIKLEMAMKELSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMH 181
            +LR  +E    + +++K  Q     KE LE+   Q  K    ++ S + T++ ++S Q  
Sbjct: 705  ELRRNVESL--KCASMKMAQLQLENKE-LESEKEQLKKGLELLKASFKKTERLEVSYQGL 761

Query: 182  ESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLSEE---MKPNLDGVDLFNNGGSGNGETK 238
            +   + L K    T E++N K Q +  +   L  E   ++ NL+ + +          +K
Sbjct: 762  DIENQRLQK----TLENSNKKIQQLESELQDLEMENQTLQKNLEELKI---------SSK 808

Query: 239  TGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTA-----------LEKEIER 287
               +L+  N  LE E +++   +  L++  K L ++ E++             LEKE + 
Sbjct: 809  RLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKT 868

Query: 288  LESALSLWKWKYEELKESKPKN---VKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRV 344
            L   + ++K     LKE + +N   VK   I +       ++L     +  +  N  +++
Sbjct: 869  LSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKL 928

Query: 345  ICELRA---ELERLQAENTSEWDKREILERE-----KQGLERENRRLKIQVKEMEELLDK 396
              EL       ERL  +  S  D+ ++LE +     K+ LE +  ++      +EE  + 
Sbjct: 929  THELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNY 988

Query: 397  KNRLSANSQSPDFKMSQIDLQEKNQELLN----LQHAYYKLNRQYQANIAELTHANNRVD 452
              +L    ++       +  ++  + ++     +     K  R+ Q    EL    +R+ 
Sbjct: 989  NQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLI 1048

Query: 453  QNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRHLQ 511
            + E     L+   + LK  L Q E + ++   QI  LQR     +E+N  L+T+   LQ
Sbjct: 1049 EVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQ 1107



 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 82/368 (22%), Positives = 162/368 (44%), Gaps = 38/368 (10%)

Query: 65   NKWDICEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLR 124
            NKW+   +   REL +VK R  ++E+                + ++AE+ + + + +QL 
Sbjct: 1027 NKWERESQETTRELLKVKDRLIEVERNN--------------ATLQAEKQALKTQLKQLE 1072

Query: 125  IKLEMAMKELSTLKKKQ-SLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQ---- 179
             +      ++  L+++  SL  Q   L+   TQ+ KL   VE S  ++    L +Q    
Sbjct: 1073 TQNNNLQAQILALQRQTVSLQEQNTTLQ---TQNAKLQ--VENSTLNSQSTSLMNQNAQL 1127

Query: 180  -MHESIREYLVKRQFSTKEDTNNKEQGVVID--SLKLSEEMKPNLDGVDLFNNGGSGNGE 236
             + +S  E   +     +ED  +    ++ D   L+L  E + + +   L +  G+    
Sbjct: 1128 LIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQAS-EYESLISKHGTLKSA 1186

Query: 237  TKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWK 296
             K    L+  +  LE+   ++   +  L++ +K+L  E+E      K  E + +      
Sbjct: 1187 HKN---LEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLC 1243

Query: 297  WKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQ 356
             + + L  +  + +KE ++L   H + ++ L  N K E   Q   +    +L+ + ++L 
Sbjct: 1244 GENDRLNHTYSQLLKETEVLQTDHKN-LKSLLNNSKLE---QTRLEAEFSKLKEQYQQLD 1299

Query: 357  AENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPD-FKMSQID 415
              +T   ++ E+L + K  LE ENR L  Q++ +  +L  +  L  N +S D F + Q  
Sbjct: 1300 ITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTL--MLQNRTLLEQNMESKDLFHVEQRQ 1357

Query: 416  LQEKNQEL 423
              +K  EL
Sbjct: 1358 YIDKLNEL 1365



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 96/428 (22%), Positives = 168/428 (39%), Gaps = 70/428 (16%)

Query: 112  ERNSAREEGRQLRIKLEMAMKELSTLKKKQSLPPQK-EALEANVTQDLKLPGFVEESCEH 170
            ER    E+    R KL +  K  STLKK   +  +K  ALEA +          EES  +
Sbjct: 940  ERLLHDEQSTDDRYKL-LESKLESTLKKSLEIKEEKIAALEARL----------EESTNY 988

Query: 171  TDQFQLSSQMHESIREYLVKRQFSTK----------EDTN--NKEQGVVIDSLKLSEEMK 218
              Q +   +  +   E L +RQ   +          ED     + Q    + LK+ + + 
Sbjct: 989  NQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRL- 1047

Query: 219  PNLDGVDLFNNGGSGNGETKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMR 278
                 +++  N  +   E +      A+   L+   T+ + LQ  +   Q+     +E  
Sbjct: 1048 -----IEVERNNATLQAEKQ------ALKTQLKQLETQNNNLQAQILALQRQTVSLQEQN 1096

Query: 279  TALEKEIERLESALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQ 338
            T L+ +  +L+   S    +   L     +       LL Q +    E    IKE    +
Sbjct: 1097 TTLQTQNAKLQVENSTLNSQSTSLMNQNAQ-------LLIQQSSLENENESVIKEREDLK 1149

Query: 339  NSKDRVICELRAELERLQAENTSEWD----KREILEREKQGLERENRRLKIQVKEMEELL 394
            +  D +I +   +LE L     SE++    K   L+   + LE E+R L+       +LL
Sbjct: 1150 SLYDSLIKD-HEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLE---DRYNQLL 1205

Query: 395  DKKNRLSANSQSPDFKMSQIDLQEKNQELL------------NLQHAYYKLNRQYQANIA 442
             +K +L    +    +  ++ L+ KN E +             L H Y +L +  +  + 
Sbjct: 1206 KQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLK--ETEVL 1263

Query: 443  ELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNEN 502
            +  H N +   N +++++ RL  E  K  L ++  +LD +     KL    +   +   N
Sbjct: 1264 QTDHKNLKSLLNNSKLEQTRLEAEFSK--LKEQYQQLDITST---KLNNQCELLSQLKGN 1318

Query: 503  LETELRHL 510
            LE E RHL
Sbjct: 1319 LEEENRHL 1326



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 84/413 (20%), Positives = 166/413 (40%), Gaps = 32/413 (7%)

Query: 117 REEGRQLRIKLEMAMKE----LSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTD 172
           ++E  Q+ I+L+   +E    LS  +  +    + +AL     +  KL   V    E   
Sbjct: 278 KQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLH 337

Query: 173 QFQLSSQMHESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGS 232
             +      E ++E   +    TK    ++ +G    S KL E  K NL      ++   
Sbjct: 338 DIEFYKARVEELKEDN-QVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDM-- 394

Query: 233 GNGETKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWK-EREMRTA---------LE 282
              E +  +  K I   +E  +T   A +  +DE   + W+ E+  RT+         L 
Sbjct: 395 ---EMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLG 451

Query: 283 KEIERLESALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKD 342
            E+  L S+  L   K E   +S  K V+E    +        ++   +K E ++Q    
Sbjct: 452 HEVNELTSSRLL---KLEMENQSLTKTVEELRTTVDSVEGNASKI---LKMEKENQRLSK 505

Query: 343 RV-ICELRAELERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLS 401
           +V I E     E+   +N     K   L +EK  LE+    L+   +   ++L+++N   
Sbjct: 506 KVEILENEIVQEKQSLQNCQNLSKD--LMKEKAQLEKTIETLRENSERQIKILEQENEHL 563

Query: 402 ANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKL 461
             + S   + SQI  + + +++       ++  ++  + ++++     ++ +     K+ 
Sbjct: 564 NQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEK 623

Query: 462 RLRVEELKQGLNQKEDE---LDDSLNQIRKLQRSLDEEKERNENLETELRHLQ 511
             R EEL+  L+  E E   L   +  ++     ++  ++ N  LE E R L+
Sbjct: 624 GERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLK 676



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 59/260 (22%), Positives = 117/260 (45%), Gaps = 26/260 (10%)

Query: 273 KEREMRTALEKEIERLESALSLWKWKYEELKESKPKNVKEFDILLG--QHNDEMQELSGN 330
           K R +R  LE++ E+L       +    ELK  + +N+           + DE+  L   
Sbjct: 259 KIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREK 318

Query: 331 I----KEESKSQNSKDRV--ICELRAELERLQAENTSEWDKREILEREKQG--------- 375
                K ES+    K+R+  I   +A +E L+ +N    + + +LE + +G         
Sbjct: 319 AVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLH 378

Query: 376 -LERENRRLKIQVK--EMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYYK 432
            LE+EN +LK ++   EME  +D+K       ++   +M+Q   ++   E L+L     +
Sbjct: 379 ELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQ---KQSMDESLHLGWELEQ 435

Query: 433 LNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRS 492
           ++R  + + A      + V  NE    +L L++E   Q L +  +EL  +++ +      
Sbjct: 436 ISRTSELSEAPQKSLGHEV--NELTSSRL-LKLEMENQSLTKTVEELRTTVDSVEGNASK 492

Query: 493 LDEEKERNENLETELRHLQN 512
           + + ++ N+ L  ++  L+N
Sbjct: 493 ILKMEKENQRLSKKVEILEN 512


>gi|148762940 DVL-binding protein DAPLE [Homo sapiens]
          Length = 2028

 Score = 69.7 bits (169), Expect = 6e-12
 Identities = 104/484 (21%), Positives = 196/484 (40%), Gaps = 67/484 (13%)

Query: 70  CEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSARE---EGRQLRIK 126
           C+E +L +++  KAR  ++ +      +  A   E+ +  RA  +   E   E  QL+ K
Sbjct: 335 CKE-KLHDVDFYKARMEELREDNIILIETKAMLEEQLTAARARGDKVHELEKENLQLKSK 393

Query: 127 LEMAMKELSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCE---HTDQFQLSSQMHES 183
           L     +  T KK+      +E LE N+  ++     + ES       +Q   ++ + ++
Sbjct: 394 LHDLELDRDTDKKRI-----EELLEENMVLEIAQKQSMNESAHLGWELEQLSKNADLSDA 448

Query: 184 IREYLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRL 243
            R+  V   F   E  +++   +  ++  L   ++   D   +    G   GE       
Sbjct: 449 SRKSFV---FELNECASSRILKLEKENQSLQSTIQGLRDASLVLEESGLKCGE------- 498

Query: 244 KAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELK 303
                 LE E  ++S     +++ Q  L +E++    LE   E L       +   E LK
Sbjct: 499 ------LEKENHQLSK---KIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDMETLK 549

Query: 304 ESKPKNVKEFDILLGQHNDEMQEL--------SGNIKEESKSQNSKDRVICELRAELERL 355
             K + +K+ +      N  M  L           +K+  K   +  + + E   +L +L
Sbjct: 550 ADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEANGKLSQL 609

Query: 356 QAENTS----------EWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQ 405
           + E             + ++ E LERE Q L+ EN RL  +V  +E   +K   L   SQ
Sbjct: 610 EFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGRLARKVTSLETATEKVEALEHESQ 669

Query: 406 -----SPDFKMSQIDLQEKNQELLNLQHAYYKL---NRQYQANIAELTHANNRVDQNEAE 457
                +   + S   LQ  + +L  L+    +L   N + +  +  +   + ++ Q E E
Sbjct: 670 GLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVETMRFTSTKLAQMERE 729

Query: 458 VKKLRLRVEELK------QGLNQKEDELDDSLNQIR----KLQRSLDEEKERNENLETEL 507
            ++L    EEL+      + L +K + L+ S   +     +LQ+SL+    + + LE+EL
Sbjct: 730 NQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSHKTQTLESEL 789

Query: 508 RHLQ 511
             L+
Sbjct: 790 GELE 793



 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 59/277 (21%), Positives = 120/277 (43%), Gaps = 16/277 (5%)

Query: 239 TGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWK 298
           T  RL+ +   LE++  ++   +  +D+    L K ++    L  +     +    ++ +
Sbjct: 259 TKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSARA----YRDE 314

Query: 299 YEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAE 358
            + L+E K   V+  ++ L +  +++ ++    K   +     + ++ E +A LE     
Sbjct: 315 LDSLRE-KANRVERLELELTRCKEKLHDVDF-YKARMEELREDNIILIETKAMLEEQLTA 372

Query: 359 NTSEWDKREILEREKQGLERENRRLKIQ----VKEMEELLDKKNRLS-ANSQSPDFKMS- 412
             +  DK   LE+E   L+ +   L++      K +EELL++   L  A  QS +     
Sbjct: 373 ARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIEELLEENMVLEIAQKQSMNESAHL 432

Query: 413 --QIDLQEKNQELLNLQHA--YYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEEL 468
             +++   KN +L +       ++LN    + I +L   N  +      ++   L +EE 
Sbjct: 433 GWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASLVLEES 492

Query: 469 KQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLET 505
                + E E      +I KLQ  L+ EK+ N++LET
Sbjct: 493 GLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLET 529



 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 78/419 (18%), Positives = 171/419 (40%), Gaps = 62/419 (14%)

Query: 104  EKWSKVRAERNSAREEGRQLRIKLEMAMKELSTLKKKQS---------LPPQKEALEANV 154
            EK   + A+        RQL  +L+M  KE  TL++ Q            P  +   ++ 
Sbjct: 977  EKIVLLEAQMEEKASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAASHQ 1036

Query: 155  TQDLKLPGFVEESCEHTDQFQLSSQMHESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLS 214
             ++   PG  E + E       + ++  +      ++Q   ++  + + Q V   S  L+
Sbjct: 1037 GKEAWGPGHKEATMELLRVKDRAIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQILT 1096

Query: 215  EEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWKE 274
                  L     F    +   +T+T  +L+  N  L ++   ++A    L         E
Sbjct: 1097 ------LQKQSAFLQEHNTTLQTQTA-KLQVENSTLSSQSAALTAQYTLLQNHHTAKETE 1149

Query: 275  REMRTALEKEIERLESALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEE 334
             E   +L+++ E+L +A       +E L     +   E++ L+ QH+  ++ L  N++ E
Sbjct: 1150 NE---SLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSC-LKTLHRNLELE 1205

Query: 335  SKSQNSKDRVICELRAELERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEELL 394
             K    +   + + +AELE          ++ ++L  E++ L++E R   + + E + L 
Sbjct: 1206 HKELGERHGDMLKRKAELE----------EREKVLTTEREALQQEQRTNALAMGENQRLR 1255

Query: 395  DKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQN 454
             + +R++                            +++L  +Y+   A        ++  
Sbjct: 1256 GELDRVN--------------------------FLHHQLKGEYEELHAHTKELKTSLNNA 1289

Query: 455  EAEVKKLRLRVEELK---QGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRHL 510
            + E+ + + R +ELK   Q ++    +LD+    + +L+ +L+EE   N +L ++++ L
Sbjct: 1290 QLELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRLKGNLEEE---NHHLLSQIQLL 1345



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 100/480 (20%), Positives = 197/480 (41%), Gaps = 91/480 (18%)

Query: 75   LRELEEV--KARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAMK 132
            LRE  +V  +AR   +EK  +           K S++  E+     +  Q + K E A K
Sbjct: 573  LRERSQVSSEARMKDVEKENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEK 632

Query: 133  ---ELSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQ-FQLSSQMHESIREYL 188
               EL  L+++     +K       T+ +       E+ EH  Q  QL ++         
Sbjct: 633  LERELQRLQEENGRLARKVTSLETATEKV-------EALEHESQGLQLENRT-------- 677

Query: 189  VKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINL 248
            +++   T ++ + + +G+  D+ +L  E   NL+   L         ET      K   +
Sbjct: 678  LRKSLDTLQNVSLQLEGLERDNKQLDAE---NLELRRLV--------ETMRFTSTKLAQM 726

Query: 249  PLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLE---SALSLWKWKYEELKES 305
              EN+          L+  ++ L K  ++  AL K+ ERLE    ++S    + ++  ES
Sbjct: 727  ERENQ---------QLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLES 777

Query: 306  KPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWDK 365
                 +  +  LG+   E Q L  +++            +    A+LE  + +  +   +
Sbjct: 778  SSHKTQTLESELGELEAERQALRRDLE-----------ALRLANAQLEGAEKDRKALEQE 826

Query: 366  REILEREKQGLERENRRLKIQVKEMEELLD----KKNRLSANSQSPDFKMSQIDLQEKNQ 421
               LE++K+ LE+E +RL  QV+  + +LD    K + +   S++ D ++++   ++   
Sbjct: 827  VAQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELAR--CRDAAG 884

Query: 422  ELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQ-----GLN--- 473
            +L  L+     L +Q   +   LT     +   + + ++L   +++L Q     GLN   
Sbjct: 885  KLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNREL 944

Query: 474  --QKEDELDDSLNQIRK--------------------LQRSLDEEKERNENLETELRHLQ 511
              Q++D   D+  +I +                    L+  ++E+   N  LE+EL+ L+
Sbjct: 945  LLQEDDSGSDTKYKILEGRNESALKTTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLK 1004



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 38/165 (23%), Positives = 79/165 (47%), Gaps = 17/165 (10%)

Query: 236  ETKTGLRLKAINLPLENEVTEISALQVHLD-EFQKILWKEREMRTALEKEIERLESALSL 294
            E +T       N  L  E+  ++ L   L  E++++    +E++T+L       +  L+ 
Sbjct: 1240 EQRTNALAMGENQRLRGELDRVNFLHHQLKGEYEELHAHTKELKTSLNNA----QLELNR 1295

Query: 295  WKWKYEELKESKPKNVKEFDILLGQ---HNDEMQELSGNIKEESKSQNSKDRVICELRAE 351
            W+ +++ELKE      +  DI L +   H + +  L GN++EE+    S+ +++ +    
Sbjct: 1296 WQARFDELKEQH----QTMDISLTKLDNHCELLSRLKGNLEEENHHLLSQIQLLSQQNQM 1351

Query: 352  LERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDK 396
            L     EN     K +  E +KQ +++ N   + + K  E+++D+
Sbjct: 1352 LLEQNMEN-----KEQYHEEQKQYIDKLNALRRHKEKLEEKIMDQ 1391



 Score = 39.7 bits (91), Expect = 0.007
 Identities = 82/367 (22%), Positives = 148/367 (40%), Gaps = 59/367 (16%)

Query: 52   HAAHNFCAHSYNTNKWDICEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRA 111
            H A    A       W    +    EL  VK RA ++E+                + ++A
Sbjct: 1026 HPAGKTAASHQGKEAWGPGHKEATMELLRVKDRAIELERNN--------------AALQA 1071

Query: 112  ERNSAREEGRQLRIKLEMAMKELSTLKKKQS-LPPQKEALEANVTQDLKLPGFVEESCEH 170
            E+   +E+ + L  +      ++ TL+K+ + L      L+   TQ  KL   VE S   
Sbjct: 1072 EKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEHNTTLQ---TQTAKLQ--VENST-- 1124

Query: 171  TDQFQLSSQMHESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLS-EEMKPNLDGVDLFNN 229
                 LSSQ      +Y + +   T ++T N+      + L  + E +  + + +   + 
Sbjct: 1125 -----LSSQSAALTAQYTLLQNHHTAKETENESLQRQQEQLTAAYEALLQDHEHLGTLHE 1179

Query: 230  GGSGNGET--KTGLRLKAINLPLENEVTEISAL-------QVHLDEFQKILWKEREMRTA 280
              S   E   +    LK ++  LE E  E+          +  L+E +K+L  ERE   A
Sbjct: 1180 RQSAEYEALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAELEEREKVLTTERE---A 1236

Query: 281  LEKEIERLESALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNS 340
            L++E  +  +AL++ +       +     +   + L  Q   E +EL  + KE   S N+
Sbjct: 1237 LQQE--QRTNALAMGE------NQRLRGELDRVNFLHHQLKGEYEELHAHTKELKTSLNN 1288

Query: 341  KDRVICELRAELERLQAEN-------TSEWDKREILEREKQGLERENRRLKIQVKEMEEL 393
                +   +A  + L+ ++       T   +  E+L R K  LE EN  L  Q+    +L
Sbjct: 1289 AQLELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRLKGNLEEENHHLLSQI----QL 1344

Query: 394  LDKKNRL 400
            L ++N++
Sbjct: 1345 LSQQNQM 1351


>gi|16262452 cingulin [Homo sapiens]
          Length = 1203

 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 62/259 (23%), Positives = 118/259 (45%), Gaps = 17/259 (6%)

Query: 257  ISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELKESKPKNVKEFDIL 316
            +S LQ  +   ++ L   +  R     + E L   L   + + E  K S+    ++   L
Sbjct: 908  LSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGL 967

Query: 317  LGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWDKREILEREKQGL 376
                 +++  L   + EE  +       +   R ++++L+ E   E   R+ LE +K  L
Sbjct: 968  ----EEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISL 1023

Query: 377  ERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQ 436
            ER+N+ LK ++   E    +K   S +      ++ Q  LQ + +E   LQ    KL R+
Sbjct: 1024 ERQNKDLKTRLASSEGF--QKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERK 1081

Query: 437  YQANIAELT----HANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRS 492
             +    ++     H N++ DQ       L LRV+ LK+ +++ E+E++      +K QR 
Sbjct: 1082 VKELSIQIEDERQHVNDQKDQ-------LSLRVKALKRQVDEAEEEIERLDGLRKKAQRE 1134

Query: 493  LDEEKERNENLETELRHLQ 511
            ++E+ E NE L+  ++ L+
Sbjct: 1135 VEEQHEVNEQLQARIKSLE 1153



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 104/476 (21%), Positives = 201/476 (42%), Gaps = 60/476 (12%)

Query: 77   ELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAMKELST 136
            E +++ A    +++ +   S+ T +W+  + K + +  + ++E  QLR++ E   +EL  
Sbjct: 546  ERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELG- 604

Query: 137  LKKKQSLPPQKEALEANVTQDLKLPGFVEE---SCEHTDQFQLSSQMHESI---REYLVK 190
             +K + L  + E   A+     ++    +E   + E   + Q   Q  E     R+  ++
Sbjct: 605  -EKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELE 663

Query: 191  RQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNG-----------GSGNGETKT 239
            +Q +      ++ + +   +L+L + ++      +  +             G      +T
Sbjct: 664  KQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVET 723

Query: 240  GLR--------LKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESA 291
             LR         +   L LE ++ E   L   +D  + +  + R+    LE E ++LE A
Sbjct: 724  TLRETQEENDEFRRRILGLEQQLKETRGL---VDGGEAVEARLRDKLQRLEAEKQQLEEA 780

Query: 292  LSLWKWKYEEL---KESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICEL 348
            L+  + +   L   K +    ++E    L +   E Q L+  ++EE K +    R   EL
Sbjct: 781  LNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAEL 840

Query: 349  RAELERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPD 408
              E +RL        +K    E EK G + +    ++Q  ++E+  +K  R  A++Q   
Sbjct: 841  E-EQKRLLDRTVDRLNK----ELEKIGEDSKQALQQLQA-QLEDYKEKARREVADAQR-Q 893

Query: 409  FKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVD-----------QNEAE 457
             K    + ++ +  L  LQ    +L +  QA+ AE   A  R+D           + EAE
Sbjct: 894  AKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTA--RLDKELLAQRLQGLEQEAE 951

Query: 458  VKKLRL--RVEELKQGLNQK----EDELDDSLNQIRKLQRSLDEEKERNENLETEL 507
             KK     R  +LK GL +K    E ELD+  N +  L   ++  +++ + L TEL
Sbjct: 952  NKKRSQDDRARQLK-GLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTEL 1006



 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 109/501 (21%), Positives = 197/501 (39%), Gaps = 101/501 (20%)

Query: 71  EELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMA 130
           E+LRLRE E    + A  E+              +  +V   R   + +  QLR  ++ A
Sbjct: 488 EQLRLRERELTALKGALKEEVA-----------SRDQEVEHVRQQYQRDTEQLRRSMQDA 536

Query: 131 MKELSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIREYLVK 190
            ++ + L+ ++    +  AL   + ++L      EE+ E T  +Q   Q +         
Sbjct: 537 TQDHAVLEAERQ---KMSALVRGLQREL------EETSEETGHWQSMFQKN--------- 578

Query: 191 RQFSTKEDTNNKEQGVV---IDSLKLSEEMKPNLDGVDL-FNNGGSGNGETKTGLRLKAI 246
                KED    +Q ++   ++  ++ EE+   ++ +        +  G+T+    LK  
Sbjct: 579 -----KEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKE 633

Query: 247 NLPLENEVTEISALQV-------HLD-EFQK---ILWKEREMRTALEKEIERLESALSLW 295
            L  + E+ E+ A +        H D E +K   +L  E +    LE++  +L+  L   
Sbjct: 634 LLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQL 693

Query: 296 KWKYEELKESKPKNVKEFDI-LLGQH--------------NDEMQE----LSGNIKEESK 336
           +   EE   SK K V E +  +LGQ               NDE +     L   +KE   
Sbjct: 694 RQDCEEA--SKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRG 751

Query: 337 SQNSKDRVICELRAELERLQAE--------NTSEWDKREI----------LEREKQGLER 378
             +  + V   LR +L+RL+AE        N S+ ++  +          LE  ++GL R
Sbjct: 752 LVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLAR 811

Query: 379 E-------NRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYY 431
                   NR L+ + K+ E L   K  L    +  D  + ++     N+EL  +     
Sbjct: 812 LGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRL-----NKELEKIGEDSK 866

Query: 432 KLNRQYQANIAELTH-ANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQ 490
           +  +Q QA + +    A   V   + + K      E+   GL++ +DE+      ++  Q
Sbjct: 867 QALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQ 926

Query: 491 RSLDEEKERNENLETELRHLQ 511
              D  +   E L   L+ L+
Sbjct: 927 AERDTARLDKELLAQRLQGLE 947



 Score = 45.8 bits (107), Expect = 9e-05
 Identities = 55/269 (20%), Positives = 112/269 (41%), Gaps = 44/269 (16%)

Query: 251 ENEVT-EISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELKESKPKN 309
           + E+T ++  LQ  LDE  K   K    +  LE+++E      S    + +EL E +   
Sbjct: 361 QGELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECS----RLQELLERRKGE 416

Query: 310 VKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSE------- 362
            +       Q N E+Q +   + +    ++  +  + EL+ +L+ +Q    ++       
Sbjct: 417 AQ-------QSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDL 469

Query: 363 WDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQE 422
            + RE+LE   +G +R   +L+++ +E+  L   K  L     S D ++  +        
Sbjct: 470 LETRELLEEVLEGKQRVEEQLRLRERELTAL---KGALKEEVASRDQEVEHV-------- 518

Query: 423 LLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDS 482
                       +QYQ +  +L  +     Q+ A ++  R ++  L +GL +   EL+++
Sbjct: 519 -----------RQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQR---ELEET 564

Query: 483 LNQIRKLQRSLDEEKERNENLETELRHLQ 511
             +    Q    + KE     + EL  L+
Sbjct: 565 SEETGHWQSMFQKNKEDLRATKQELLQLR 593



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 57/285 (20%), Positives = 116/285 (40%), Gaps = 23/285 (8%)

Query: 250 LENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALS-----------LWKWK 298
           LE    E       L   +++L +  ++R  LE ++  L++ L            L K  
Sbjct: 410 LERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDL 469

Query: 299 YE--ELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSK-DRVICELRAELERL 355
            E  EL E   +  +  +  L     E+  L G +KEE  S++ + + V  + + + E+L
Sbjct: 470 LETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQL 529

Query: 356 QAENTSEWDKREILEREKQ-------GLERENRRLKIQVKEMEELLDK-KNRLSANSQSP 407
           +           +LE E+Q       GL+RE      +    + +  K K  L A  Q  
Sbjct: 530 RRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQEL 589

Query: 408 -DFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVE 466
              +M + +++E+  E + +     +  R    +  ++      + + + E+K+L+   +
Sbjct: 590 LQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQ 649

Query: 467 ELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRHLQ 511
             +     ++ EL+  L  +R       E +E+N  L+  L+ L+
Sbjct: 650 SQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLR 694



 Score = 31.6 bits (70), Expect = 1.8
 Identities = 16/57 (28%), Positives = 34/57 (59%), Gaps = 3/57 (5%)

Query: 459 KKLRLRVEE---LKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRHLQN 512
           ++L  + EE   L++ L +++ E   S  +++ ++R LD+ ++    LET++  LQN
Sbjct: 394 RQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQVMELQN 450


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 98/460 (21%), Positives = 195/460 (42%), Gaps = 40/460 (8%)

Query: 76   RELEEVKARA--AQMEKTMRWW--SDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAM 131
            +ELE  KA    + MEK  R     +  +  +++ S +R +   A+ E ++L  ++E+  
Sbjct: 1048 KELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLR 1107

Query: 132  KELSTLKKKQSLPPQKEALE----ANVT-QDLKLPGFVEESCEHTDQFQLSSQMHESIRE 186
            +E+   K+   L  + + LE    +++T Q L+   + +E+     Q QL  +  ES  E
Sbjct: 1108 QEVKE-KEADFLAQEAQLLEELEASHITEQQLRASLWAQEA--KAAQLQLRLRSTESQLE 1164

Query: 187  YLVKRQFSTKEDTNNKEQGVVIDSLKLSE----EMKPNLDGVDLFNNGGSGNGETKTGLR 242
             L   Q    +     +   +  +L+ +     E +P L G         G    + G R
Sbjct: 1165 ALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGAR 1224

Query: 243  LKAINLPLENEVTEISALQVH--LDEFQKILWKEREMRTALEKEIERLESALSLWKWKYE 300
                  PL   +T +SA  V   L +  + LWK ++ R  L  ++++LE  L+      E
Sbjct: 1225 SLFKRGPL---LTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLT----DTE 1277

Query: 301  ELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENT 360
              K      +++    L Q+ +E  +  G               +  L++ L R + +  
Sbjct: 1278 AEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRM 1337

Query: 361  SEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKN 420
                +RE+L+  K+ L  +   L+  V E      +    +A     D + ++  L+ KN
Sbjct: 1338 EAQGERELLQAAKENLTAQVEHLQAAVVEA-----RAQASAAGILEEDLRTARSALKLKN 1392

Query: 421  QELLNLQHAYYKLNRQYQANIAE-------LTHANNRVDQNEAEVKKLRLRVEELKQGLN 473
            +E+ + +     L  Q +  +A+       L      + + E EV+ LR +++EL++   
Sbjct: 1393 EEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQRE 1452

Query: 474  QKEDELDDSLNQIRKLQRSLDEEKERNENLE---TELRHL 510
             ++  L+     ++K  + +D ++E+ + LE   + L HL
Sbjct: 1453 MQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHL 1492



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 87/447 (19%), Positives = 184/447 (41%), Gaps = 48/447 (10%)

Query: 77   ELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMA-MKELS 135
            E  +V      +++ +    +  + W  K + + +E     E    L+ +L  A ++ + 
Sbjct: 1279 EKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRME 1338

Query: 136  TLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIREYLVKRQFST 195
               +++ L   KE L A V     L   V E+     Q   +  + E +R      +   
Sbjct: 1339 AQGERELLQAAKENLTAQVEH---LQAAVVEA---RAQASAAGILEEDLRTARSALKLKN 1392

Query: 196  KEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLENEVT 255
            +E  + +E+     +L+   E+K    G  L  N             L  +   L     
Sbjct: 1393 EEVESERERA---QALQEQGELKV-AQGKALQEN-------------LALLTQTLAEREE 1435

Query: 256  EISALQVHLDEFQKILWKEREMRTA----LEKEIERLESALSLWKWKYEELKESK----- 306
            E+  L+  + E +K    +REM+ A    L  ++++    + L + + +EL++ +     
Sbjct: 1436 EVETLRGQIQELEK----QREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEH 1491

Query: 307  -PKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWD- 364
             P  V+E +  L    ++++EL    K+    +N  +  + EL  + + ++++     D 
Sbjct: 1492 LPMAVQEREQKLTVQREQIRELE---KDRETQRNVLEHQLLELEKKDQMIESQRGQVQDL 1548

Query: 365  KREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELL 424
            K++++  E   LE E    K+   E ++ L K+      +Q        +DL+E++QEL 
Sbjct: 1549 KKQLVTLECLALELEENHHKM---ECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQ 1605

Query: 425  NLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSLN 484
                  + L         EL   +  V     ++++L+ + E L Q L +++ EL   + 
Sbjct: 1606 AQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQEL---ML 1662

Query: 485  QIRKLQRSLDEEKERNENLETELRHLQ 511
            Q  ++Q   D+   + + LE +L  ++
Sbjct: 1663 QKERIQVLEDQRTRQTKILEEDLEQIK 1689



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 68/292 (23%), Positives = 132/292 (45%), Gaps = 52/292 (17%)

Query: 236  ETKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLW 295
            E +T        + LE E   +S L+        +L  ++E+  A  +++ERL   + + 
Sbjct: 907  EERTQAESALCQMQLETEKERVSLLET-------LLQTQKELADA-SQQLERLRQDMKVQ 958

Query: 296  KWKYEE----LKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAE 351
            K K +E    L+    +  +E      QH D++  L     +E  S   +D++  +L+ +
Sbjct: 959  KLKEQETTGILQTQLQEAQRELKEAARQHRDDLAAL-----QEESSSLLQDKM--DLQKQ 1011

Query: 352  LERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKM 411
            +E L+++  ++ D + ++E+E Q   RE +      KE+E    +K  L+          
Sbjct: 1012 VEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELER---EKASLT---------- 1058

Query: 412  SQIDLQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQG 471
              + L EK Q LL LQ A   + +Q      EL+     + + + E K+L  ++E L+Q 
Sbjct: 1059 --LSLMEKEQRLLVLQEA-DSIRQQ------ELSALRQDMQEAQGEQKELSAQMELLRQE 1109

Query: 472  LNQKE-----------DELDDSLNQIRKLQRSLDEEKERNENLETELRHLQN 512
            + +KE           +EL+ S    ++L+ SL  ++ +   L+  LR  ++
Sbjct: 1110 VKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTES 1161



 Score = 52.8 bits (125), Expect = 8e-07
 Identities = 89/449 (19%), Positives = 182/449 (40%), Gaps = 56/449 (12%)

Query: 103  REKWSKVRA----ERNSAREEGRQLRIKLEMAMKELSTLKKKQSLPPQKEALEA------ 152
            REKW K R+    E   A E   + +++LEM +KE  T  +      ++E  +A      
Sbjct: 859  REKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQ 918

Query: 153  -NVTQDLKLPGFVEESCEHTDQFQLSSQMHESIREYLVKRQFSTKEDTNNKEQGVVIDSL 211
              +  + +    +E   +   +   +SQ  E +R+ +  ++   +E T   +  +     
Sbjct: 919  MQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQR 978

Query: 212  KLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLENEVTEISALQVHLDEFQKIL 271
            +L E  + + D +       S   + K  L+ +  +L  +    + S   V  +  +K+ 
Sbjct: 979  ELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKL- 1037

Query: 272  WKEREMRTALEKEIERLESALSLWKWKYEE----LKESKPKNVKEFDILLGQHNDEMQEL 327
             +E +    ++KE+ER +++L+L   + E+    L+E+     +E   L      +MQE 
Sbjct: 1038 -RETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSAL----RQDMQEA 1092

Query: 328  SGNIKEESKSQNSKDRVICELRAELERLQAENTSEWDKREILEREKQ----GLERENRRL 383
             G  KE S       + + E  A+    +A+   E +   I E++ +      E +  +L
Sbjct: 1093 QGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQL 1152

Query: 384  KIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAE 443
            +++++  E  L+    L+A  Q  +   +Q        +L +L  A  +       +  E
Sbjct: 1153 QLRLRSTESQLE---ALAAEQQPGNQAQAQ-------AQLASLYSALQQALGSVCESRPE 1202

Query: 444  LTHANNRV--------DQNEA-------------EVKKLRLRVEELKQGLNQKEDELDDS 482
            L+   +          DQN A               + +   + +L Q L + +   D  
Sbjct: 1203 LSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVL 1262

Query: 483  LNQIRKLQRSLDEEKERNENLETELRHLQ 511
             +Q++KL+  L + +     + TEL+ LQ
Sbjct: 1263 RDQVQKLEERLTDTEAEKSQVHTELQDLQ 1291



 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 59/277 (21%), Positives = 122/277 (44%), Gaps = 19/277 (6%)

Query: 251 ENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELKE-----S 305
           E   T++  L       +++L +  + + AL +E   LE  L   +   ++L E     S
Sbjct: 704 EAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLS 763

Query: 306 KPKNVKEFDILLGQHNDEMQELS-GNIKEESKSQNSKDRVI------CELRAELERLQAE 358
             K + E  +   Q  + + E++ G ++ + ++      VI       +L  + ER QAE
Sbjct: 764 SAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAE 823

Query: 359 NTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQE 418
              +   R++ + E++G     ++     KE+ +L +K  +  +  Q    K  +   +E
Sbjct: 824 QERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLERE 883

Query: 419 KNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDE 478
           K +  + L+    ++         E T A + + Q + E +K R+    L + L Q + E
Sbjct: 884 KMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERV---SLLETLLQTQKE 940

Query: 479 LDDSLNQIRKLQRSLD----EEKERNENLETELRHLQ 511
           L D+  Q+ +L++ +     +E+E    L+T+L+  Q
Sbjct: 941 LADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQ 977



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 92/459 (20%), Positives = 198/459 (43%), Gaps = 79/459 (17%)

Query: 74   RLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAMKE 133
            +++ELE+ +    +M+K            R +   ++ E+    E+ R +   L MA++E
Sbjct: 1443 QIQELEKQR----EMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQE 1498

Query: 134  LSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHE-SIREYLVKRQ 192
                 ++Q L  Q+E +               E    T +  L  Q+ E   ++ +++ Q
Sbjct: 1499 -----REQKLTVQREQIREL------------EKDRETQRNVLEHQLLELEKKDQMIESQ 1541

Query: 193  FSTKEDTNNKEQGVVIDSLKLS-EEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLE 251
                +D   K+Q V ++ L L  EE    ++          G  ET+  + L  + L LE
Sbjct: 1542 RGQVQDL--KKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQR-VALTHLTLDLE 1598

Query: 252  NEVTEISAL--QVH-LDEFQKILWKEREMRTA------------------LEKEIERLES 290
                E+ A   Q+H L+    +L +E + R                    L +++ER + 
Sbjct: 1599 ERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQ 1658

Query: 291  ALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRA 350
             L L K + + L++ + +  K  +       ++++++  +++E  +   ++ +++ E RA
Sbjct: 1659 ELMLQKERIQVLEDQRTRQTKILE-------EDLEQIKLSLRERGRELTTQRQLMQE-RA 1710

Query: 351  ELERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFK 410
            E    + +  S+  +R  LE  K  L  + + ++ Q + + EL + K++L    Q    K
Sbjct: 1711 E----EGKGPSK-AQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRK 1765

Query: 411  MSQIDL--QEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEEL 468
            + +  L   ++ QE++ LQ               +L  A    +Q E + + L+ +++E 
Sbjct: 1766 VGETSLLLSQREQEIVVLQQ--------------QLQEAR---EQGELKEQSLQSQLDEA 1808

Query: 469  KQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETEL 507
            ++ L Q++ EL+    + ++ Q   +  KE+ + L+  L
Sbjct: 1809 QRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGAL 1847



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 91/464 (19%), Positives = 178/464 (38%), Gaps = 79/464 (17%)

Query: 79   EEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAMKELSTLK 138
            +E++A+++Q+       +      +E+  +V+++R    E  RQ     E   ++L   +
Sbjct: 1602 QELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQK----EHLTQDLE--R 1655

Query: 139  KKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIREYLVKRQFSTKED 198
            + Q L  QKE ++    Q  +    +EE  E     Q+   + E  RE   +RQ   +  
Sbjct: 1656 RDQELMLQKERIQVLEDQRTRQTKILEEDLE-----QIKLSLRERGRELTTQRQLMQER- 1709

Query: 199  TNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLENEVTEIS 258
                           +EE              G G  + + G  L+ + L L ++  E+ 
Sbjct: 1710 ---------------AEE--------------GKGPSKAQRG-SLEHMKLILRDKEKEVE 1739

Query: 259  ALQVHLDEFQKILWKEREMRTAL--------------EKEIERLESALSLWKWKYEELKE 304
              Q H+ E Q++  +  +    L              E+EI  L+  L   + + E  ++
Sbjct: 1740 CQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQ 1799

Query: 305  SKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWD 364
            S    + E    L Q + E++ L    +E+ ++Q  ++RV  +  A    L+  + +  +
Sbjct: 1800 SLQSQLDEAQRALAQRDQELEALQ---QEQQQAQGQEERVKEKADALQGALEQAHMTLKE 1856

Query: 365  KREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQI------DLQE 418
            +   L+  K+   R    L ++ + ++ L +    L A S+  +  +  +        QE
Sbjct: 1857 RHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQE 1916

Query: 419  KNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQ---- 474
               E   LQ ++ +     +    EL         +  + +  R R E L++ L +    
Sbjct: 1917 HEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAA 1976

Query: 475  ---------KEDELDDSLN-QIRKLQRSLDEEKERNENLETELR 508
                     ++ EL  SL      LQ SLD  +  +  LE  LR
Sbjct: 1977 LQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALR 2020



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 64/258 (24%), Positives = 111/258 (43%), Gaps = 32/258 (12%)

Query: 271 LWKEREMRTALEKEIERLESALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGN 330
           L KERE+   L+K  E L   L + + +   L+    +   + D   GQ  ++ +EL   
Sbjct: 461 LSKEREL---LQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLA 517

Query: 331 IKEESKSQNSKDRVICELRAELERLQAENTSEW-DKREILER---EKQGLERENRRLKIQ 386
           ++E  + Q        E+   LE  Q+E+ SE    RE LE    E + L +E   +   
Sbjct: 518 VRERERLQ--------EMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAA 569

Query: 387 VKEME----ELLDKKNRLS---ANSQSPDFKMSQI------DLQEKNQELLNLQHAYYKL 433
           +   E    EL   +N L    A+ ++   K+S +      D    NQ+LL L+      
Sbjct: 570 LARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEE---- 625

Query: 434 NRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSL 493
           N+   + +     A N +  + AE +K R  + E    L  +  + +++  +++   R +
Sbjct: 626 NQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDI 685

Query: 494 DEEKERNENLETELRHLQ 511
            EEKE  +   +E RH Q
Sbjct: 686 QEEKEEIQKKLSESRHQQ 703



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 95/444 (21%), Positives = 188/444 (42%), Gaps = 69/444 (15%)

Query: 70   CEELRLRELEEVKARAAQ----MEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRI 125
            C++  + EL+E+K +  Q    + + +   S   +   ++   ++ +   ARE+G     
Sbjct: 1740 CQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQ 1799

Query: 126  KLEMAMKELSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLS-SQMHESI 184
             L+  + E      +++L  + + LEA   +  +  G  E   E  D  Q +  Q H ++
Sbjct: 1800 SLQSQLDEA-----QRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTL 1854

Query: 185  REYLVKRQFSTKEDTNNKEQGVVIDSLKLS--EEMKPNLDGVDLFNNGGSGNGETKTGLR 242
            +E   + Q   KE     E+ + ++  ++   EE+  +L              +    L+
Sbjct: 1855 KERHGELQ-DHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQE------KALLALQ 1907

Query: 243  LKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEEL 302
             +      E+EV E  ALQ    + Q +L KER+     E E  R ES  S  +   EE 
Sbjct: 1908 QQCAEQAQEHEV-ETRALQDSWLQAQAVL-KERDQ----ELEALRAESQSSRHQ---EEA 1958

Query: 303  KESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSE 362
              ++ + ++E    LG+ +  +Q    ++ E+++   S +     L+A L+  QA +   
Sbjct: 1959 ARARAEALQE---ALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQL 2015

Query: 363  WDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQE 422
             +   I E E   ++ ++ R +  V+++++ L +++              ++  Q++ ++
Sbjct: 2016 EEALRIQEGE---IQDQDLRYQEDVQQLQQALAQRDE-------------ELRHQQEREQ 2059

Query: 423  LLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKL--RLRVEELKQGLNQKEDELD 480
            LL    A                    RV +N  + K+   + R EE  +GL+Q   EL 
Sbjct: 2060 LLEKSLA-------------------QRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQ 2100

Query: 481  DSLNQIRKLQRSLDEEKERNENLE 504
             +L Q  +    L E ++RN NLE
Sbjct: 2101 LTLAQKEQEILELRETQQRN-NLE 2123



 Score = 35.8 bits (81), Expect = 0.096
 Identities = 55/261 (21%), Positives = 107/261 (40%), Gaps = 35/261 (13%)

Query: 282 EKEIERLESALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSK 341
           +K +  + S L+  +   ++L++      +  ++L  QH+   +E     +   K    +
Sbjct: 385 DKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGER 444

Query: 342 DRVI---CELRAELERLQAENTSEWDKR-------EILEREKQGLERENRRLKIQ----- 386
           D +     +L+ E++ L  E       R       E+LE+E   L R N  L++Q     
Sbjct: 445 DTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQ 504

Query: 387 ---VKEMEEL---LDKKNRLSANSQSPDFKMSQIDLQE--KNQELLNLQHAYYKLNRQYQ 438
               ++ EEL   + ++ RL       + K S+  L E    +E L   H   +L RQ Q
Sbjct: 505 GQKEEQQEELHLAVRERERLQEMLMGLEAKQSE-SLSELITLREALESSHLEGELLRQEQ 563

Query: 439 A-----------NIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIR 487
                       +IAEL+ + N +    A+++   +++  L + L   +  L+  L Q+ 
Sbjct: 564 TEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLE 623

Query: 488 KLQRSLDEEKERNENLETELR 508
           +  +S+    E  E     L+
Sbjct: 624 EENQSVCSRMEAAEQARNALQ 644



 Score = 32.0 bits (71), Expect = 1.4
 Identities = 62/305 (20%), Positives = 119/305 (39%), Gaps = 61/305 (20%)

Query: 117  REEGRQLRIKLEMAMKELSTLKKKQSLPPQKEA--LEANVTQDLKLPGFVEESCEHTDQF 174
            +E+ +QL+  L    +EL   ++++ L  +  A  ++ N+ Q+ +  G   E  E     
Sbjct: 2034 QEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRG-- 2091

Query: 175  QLSSQMHESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGN 234
                 +H+S+RE  +            KEQ +    L+L E  + N   ++   +    +
Sbjct: 2092 -----LHQSVRELQLTLA--------QKEQEI----LELRETQQRN--NLEALPHSHKTS 2132

Query: 235  GETKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTAL------------- 281
               +  L+L ++   L+ E+  + A  +   E ++I W+E+    AL             
Sbjct: 2133 PMEEQSLKLDSLEPRLQRELERLQAA-LRQTEAREIEWREKAQDLALSLAQTKASVSSLQ 2191

Query: 282  -------------EKEIERLESALSLWKWKYEELKESKPKNVKEFDI-LLGQHNDEMQEL 327
                         + E +RL+  L L +   E+ +   P      ++   G+   ++ E+
Sbjct: 2192 EVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEV 2251

Query: 328  SGNIKEESKSQNSKD----------RVICELRAELERLQAENTSEWDKREILEREKQGLE 377
            SG   E S     K           + +  L  +  RLQ  N       E +ERE++ L+
Sbjct: 2252 SGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLK 2311

Query: 378  RENRR 382
            RE  R
Sbjct: 2312 REAMR 2316



 Score = 31.2 bits (69), Expect = 2.4
 Identities = 58/308 (18%), Positives = 128/308 (41%), Gaps = 45/308 (14%)

Query: 241 LRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYE 300
           ++ +++ L LE +V    ALQ  + E Q   W++ +     ++    L   L     +Y 
Sbjct: 11  MKPQSLQLVLEEQVL---ALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYR 67

Query: 301 ELKESKPKNVKEFDILLGQHNDEMQE-----LSGNIKEESKSQNSKDRVICELRAELERL 355
              +   K ++     + Q  + ++E     L   ++EE +   S   V  +LR  +E+ 
Sbjct: 68  SWCQELEKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKA 127

Query: 356 QAEN----------TSEWDK-REILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANS 404
              N          T +W + R+ L R++   + E    K  +K     L     LS   
Sbjct: 128 DVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRL-----LSLWR 182

Query: 405 QSPDFKMSQIDLQEK-NQELLNLQHAYYKLNRQYQANIAELT--------HANNRVDQNE 455
           +   F+   ++++   +++L+ L+  + +L+         LT        + + R+D  E
Sbjct: 183 EVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGRE 242

Query: 456 -AEVKKLRLRVEELKQGLNQKEDELDDSLNQ-----------IRKLQRSLDEEKERNENL 503
            A++  L  + +EL++  +++  EL    +Q           + +L   L + +++NE+ 
Sbjct: 243 PAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDY 302

Query: 504 ETELRHLQ 511
           E  ++ L+
Sbjct: 303 EKMIKALR 310


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.311    0.127    0.355 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,704,104
Number of Sequences: 37866
Number of extensions: 853220
Number of successful extensions: 10236
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 354
Number of HSP's successfully gapped in prelim test: 905
Number of HSP's that attempted gapping in prelim test: 4594
Number of HSP's gapped (non-prelim): 3798
length of query: 513
length of database: 18,247,518
effective HSP length: 107
effective length of query: 406
effective length of database: 14,195,856
effective search space: 5763517536
effective search space used: 5763517536
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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