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Search of human proteins with 148233522
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|148233522 coiled-coil domain containing 102B [Homo sapiens]
(513 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|147905592 coiled-coil domain containing 102B [Homo sapiens] 1024 0.0
gi|148233522 coiled-coil domain containing 102B [Homo sapiens] 1024 0.0
gi|226495417 coiled-coil domain containing 102A [Homo sapiens] 370 e-102
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 88 2e-17
gi|31982906 cingulin-like 1 [Homo sapiens] 87 5e-17
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 81 3e-15
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 80 6e-15
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 79 8e-15
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 79 8e-15
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 79 8e-15
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 79 1e-14
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 77 3e-14
gi|156104908 myosin heavy chain 6 [Homo sapiens] 77 4e-14
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 76 6e-14
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 74 2e-13
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 74 2e-13
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 74 2e-13
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 74 2e-13
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 74 3e-13
gi|46049114 M-phase phosphoprotein 1 [Homo sapiens] 74 3e-13
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 74 4e-13
gi|4502443 dystonin isoform 1e precursor [Homo sapiens] 74 4e-13
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 73 5e-13
gi|71061468 centromere protein E [Homo sapiens] 72 1e-12
gi|55770834 centromere protein F [Homo sapiens] 72 2e-12
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 71 3e-12
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 71 3e-12
gi|148762940 DVL-binding protein DAPLE [Homo sapiens] 70 6e-12
gi|16262452 cingulin [Homo sapiens] 68 2e-11
gi|21735548 centrosomal protein 2 [Homo sapiens] 68 2e-11
>gi|147905592 coiled-coil domain containing 102B [Homo sapiens]
Length = 513
Score = 1024 bits (2648), Expect = 0.0
Identities = 513/513 (100%), Positives = 513/513 (100%)
Query: 1 MNLDSIHRLIEETQIFQMQQSSIKSRGDMVAPASPPRDTCNTCFPLHGLQSHAAHNFCAH 60
MNLDSIHRLIEETQIFQMQQSSIKSRGDMVAPASPPRDTCNTCFPLHGLQSHAAHNFCAH
Sbjct: 1 MNLDSIHRLIEETQIFQMQQSSIKSRGDMVAPASPPRDTCNTCFPLHGLQSHAAHNFCAH 60
Query: 61 SYNTNKWDICEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEG 120
SYNTNKWDICEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEG
Sbjct: 61 SYNTNKWDICEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEG 120
Query: 121 RQLRIKLEMAMKELSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQM 180
RQLRIKLEMAMKELSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQM
Sbjct: 121 RQLRIKLEMAMKELSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQM 180
Query: 181 HESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTG 240
HESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTG
Sbjct: 181 HESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTG 240
Query: 241 LRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYE 300
LRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYE
Sbjct: 241 LRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYE 300
Query: 301 ELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENT 360
ELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENT
Sbjct: 301 ELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENT 360
Query: 361 SEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKN 420
SEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKN
Sbjct: 361 SEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKN 420
Query: 421 QELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELD 480
QELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELD
Sbjct: 421 QELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELD 480
Query: 481 DSLNQIRKLQRSLDEEKERNENLETELRHLQNW 513
DSLNQIRKLQRSLDEEKERNENLETELRHLQNW
Sbjct: 481 DSLNQIRKLQRSLDEEKERNENLETELRHLQNW 513
>gi|148233522 coiled-coil domain containing 102B [Homo sapiens]
Length = 513
Score = 1024 bits (2648), Expect = 0.0
Identities = 513/513 (100%), Positives = 513/513 (100%)
Query: 1 MNLDSIHRLIEETQIFQMQQSSIKSRGDMVAPASPPRDTCNTCFPLHGLQSHAAHNFCAH 60
MNLDSIHRLIEETQIFQMQQSSIKSRGDMVAPASPPRDTCNTCFPLHGLQSHAAHNFCAH
Sbjct: 1 MNLDSIHRLIEETQIFQMQQSSIKSRGDMVAPASPPRDTCNTCFPLHGLQSHAAHNFCAH 60
Query: 61 SYNTNKWDICEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEG 120
SYNTNKWDICEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEG
Sbjct: 61 SYNTNKWDICEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEG 120
Query: 121 RQLRIKLEMAMKELSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQM 180
RQLRIKLEMAMKELSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQM
Sbjct: 121 RQLRIKLEMAMKELSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQM 180
Query: 181 HESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTG 240
HESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTG
Sbjct: 181 HESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTG 240
Query: 241 LRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYE 300
LRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYE
Sbjct: 241 LRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYE 300
Query: 301 ELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENT 360
ELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENT
Sbjct: 301 ELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENT 360
Query: 361 SEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKN 420
SEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKN
Sbjct: 361 SEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKN 420
Query: 421 QELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELD 480
QELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELD
Sbjct: 421 QELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELD 480
Query: 481 DSLNQIRKLQRSLDEEKERNENLETELRHLQNW 513
DSLNQIRKLQRSLDEEKERNENLETELRHLQNW
Sbjct: 481 DSLNQIRKLQRSLDEEKERNENLETELRHLQNW 513
>gi|226495417 coiled-coil domain containing 102A [Homo sapiens]
Length = 550
Score = 370 bits (950), Expect = e-102
Identities = 212/449 (47%), Positives = 297/449 (66%), Gaps = 13/449 (2%)
Query: 67 WDICEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIK 126
W+ EELRLRELEE +ARAAQMEKTMR WSDCTANWREKWSKVRAERN AREE RQLR +
Sbjct: 69 WESREELRLRELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQLRQR 128
Query: 127 LEMAMKELSTLKK-KQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIR 185
L+ KEL+ ++ +Q + EA + + G +++ + + E+ R
Sbjct: 129 LDALTKELAGARRERQEAQGECEARGRELARLRGARGVADQTRDGPEP--------EAER 180
Query: 186 EYLVKRQFSTKEDTNNKEQGVVIDSLK-LSEEMKPNLDGVDLFNNGGSGNGETKTGLRLK 244
E + R ++ ++E +V LK + EE + + L G G+ + RL
Sbjct: 181 EPV--RDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLP 238
Query: 245 -AINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELK 303
E E ++++AL++ LDE QK+L KERE + AL + IE+LE LS WK KYEEL
Sbjct: 239 WEDTAATEEEASKLTALRLRLDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELS 298
Query: 304 ESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEW 363
++K + +K+ IL H DE+ +S ++++E +++S DR + ELR E+ERLQAEN +EW
Sbjct: 299 KTKQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAAEW 358
Query: 364 DKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQEL 423
+RE LE EK GLEREN++L+ QV ++EE L ++ R +A++ D + SQ L EKN+EL
Sbjct: 359 GRRERLETEKLGLERENKKLRAQVGDLEEALARRRRQTASALDCDLRASQAALFEKNKEL 418
Query: 424 LNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSL 483
+L+H + KL +Q+Q +AEL HAN RV+Q+EAEVKKLRLRVEELK+ L Q EDELD++
Sbjct: 419 ADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDELDEAH 478
Query: 484 NQIRKLQRSLDEEKERNENLETELRHLQN 512
NQ RKLQRSLDE+ E++ENL+ +L HLQ+
Sbjct: 479 NQARKLQRSLDEQTEQSENLQVQLEHLQS 507
Score = 38.1 bits (87), Expect = 0.019
Identities = 66/325 (20%), Positives = 128/325 (39%), Gaps = 39/325 (12%)
Query: 70 CEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEM 129
C E R + + + E++ W D TA E+ SK+ A LR++L+
Sbjct: 214 CWEARSLGAGGPRGSSGRQERSRLPWED-TAATEEEASKLTA-----------LRLRLDE 261
Query: 130 AMKELSTLKK-KQSLPPQKEALEANVTQ-DLKLPGFVEESCEHTDQFQLSSQMHESIREY 187
+ K L ++ K +L E LE ++Q +K + E Q + + H+
Sbjct: 262 SQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELSKTKQEMLKQLSILKEAHQD---- 317
Query: 188 LVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAIN 247
+ + E G + E++ ++ + N G E RL+
Sbjct: 318 ----ELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAAEWGRRE-----RLETEK 368
Query: 248 LPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELKESKP 307
L LE E ++ A L+E + + R+ +AL+ ++ ++AL + +LK
Sbjct: 369 LGLERENKKLRAQVGDLEE--ALARRRRQTASALDCDLRASQAALFEKNKELADLKHVHG 426
Query: 308 KNVKEFDILLG----------QHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQA 357
K K+F + QH E+++L ++E K + + E + +LQ
Sbjct: 427 KLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDELDEAHNQARKLQR 486
Query: 358 ENTSEWDKREILEREKQGLERENRR 382
+ ++ E L+ + + L+ RR
Sbjct: 487 SLDEQTEQSENLQVQLEHLQSRLRR 511
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 87.8 bits (216), Expect = 2e-17
Identities = 102/458 (22%), Positives = 204/458 (44%), Gaps = 52/458 (11%)
Query: 100 ANWREKWSKVRA------ERNSAREE----GRQLRIKLEMAMKELSTLKKK-QSLPPQKE 148
A REK +K + E A+EE +QLR +E M + K L K
Sbjct: 1476 AEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKR 1535
Query: 149 ALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIREYLVKRQFSTKEDTNNKEQGVVI 208
ALE V + +E+ + T+ +L +++ + +R T+++ N +++ ++I
Sbjct: 1536 ALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLI 1595
Query: 209 DSLK-----LSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLENEVTEISALQVH 263
++ L +E K V + + +++A N + + ++ LQ
Sbjct: 1596 KQVRELEAELEDERKQRALAVASKKKMEIDLKDLEA--QIEAANKARDEVIKQLRKLQAQ 1653
Query: 264 LDEFQKILWKEREMRTAL-------EKEIERLESALSLWKWKYEELKESKPKNVKEFDIL 316
+ ++Q+ L + R R + EK+++ LE+ + + + + ++ +E D L
Sbjct: 1654 MKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDEL 1713
Query: 317 LGQHN----------DEMQELSGNI--------KEESKSQNSKDRVICELRAELERLQAE 358
+ DE + L I +E+S + DR + +++ L AE
Sbjct: 1714 ADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDR-FRKTTLQVDTLNAE 1772
Query: 359 NTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQE 418
+E + + +Q LER+N+ LK +++E+E + K++ A + + K+ Q L+E
Sbjct: 1773 LAAERSAAQKSDNARQQLERQNKELKAKLQELEGAV--KSKFKATISALEAKIGQ--LEE 1828
Query: 419 KNQELLNLQHAYYKLNRQYQANIAEL----THANNRVDQNEAEVKKLRLRVEELKQGLNQ 474
+ ++ + A KL R+ + + E+ DQ + +++K R+++LK+ L +
Sbjct: 1829 QLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEE 1888
Query: 475 KEDELDDSLNQIRKLQRSLDEEKERNENLETELRHLQN 512
E+E + RKLQR LD+ E NE L E+ L+N
Sbjct: 1889 AEEEATRANASRRKLQRELDDATEANEGLSREVSTLKN 1926
Score = 65.9 bits (159), Expect = 9e-11
Identities = 119/531 (22%), Positives = 221/531 (41%), Gaps = 96/531 (18%)
Query: 65 NKWDICEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLR 124
NK CE ++ L++VKA + K + A +E +KV +E + R E +
Sbjct: 1233 NKELACE---VKVLQQVKAESEHKRKKL------DAQVQELHAKV-SEGDRLRVELAEKA 1282
Query: 125 IKLEMAMKELSTL------------KKKQSLPPQ----KEALEANVTQDLKLPGFVEESC 168
KL+ + +STL K SL Q +E L+ Q L L + +
Sbjct: 1283 SKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLE 1342
Query: 169 EHTDQFQLSSQMHESIREYLVKRQFSTKE---DTNNKEQGVVIDSLKLSEEMKPNLDGVD 225
E + Q + E R+ L K+ + + DT K + L E K L +
Sbjct: 1343 EEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAE 1402
Query: 226 LFNNGGSGNG-------ETKTGLR--LKAINLPLENEVTEISALQVHLDEFQKILWKERE 276
+ +TK L+ L + + L+++ S L+ +F ++L +E+
Sbjct: 1403 ALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKS 1462
Query: 277 MRTALEKEIERLES--------ALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQ--- 325
+ +E +R E+ ALSL + EE E+K + ++ L D M
Sbjct: 1463 ISARYAEERDRAEAEAREKETKALSLAR-ALEEALEAKEEFERQNKQLRADMEDLMSSKD 1521
Query: 326 ELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWD----------------KREIL 369
++ N+ E KS+ + ++ + E+R +LE L+ E + D +R++
Sbjct: 1522 DVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQ 1581
Query: 370 EREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHA 429
R++Q E++ +K QV+E+E L+ + + A + + KM +IDL++ ++ A
Sbjct: 1582 TRDEQNEEKKRLLIK-QVRELEAELEDERKQRALAVASKKKM-EIDLKDLEAQIEAANKA 1639
Query: 430 YYKLNRQ----------YQANIAELTHANNRV----DQNEAEVKKLRLRVEELKQGL--- 472
++ +Q YQ + E + + + ++E ++K L + +L++ L
Sbjct: 1640 RDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASS 1699
Query: 473 -------NQKEDELDDSLNQIRKLQRSLDEEKERNE----NLETELRHLQN 512
Q+ DEL D + + +L +EK R E LE EL Q+
Sbjct: 1700 ERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQS 1750
Score = 57.0 bits (136), Expect = 4e-08
Identities = 100/462 (21%), Positives = 192/462 (41%), Gaps = 52/462 (11%)
Query: 70 CEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSARE--EGRQLRIKL 127
C E E+ K A K SD +++ K R E A+ +G ++
Sbjct: 1011 CSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKE-EKTRQELEKAKRKLDGETTDLQD 1069
Query: 128 EMAMKELSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIREY 187
++A + + K L ++E L+ + + +E+ + ++ ++ I E
Sbjct: 1070 QIAELQAQIDELKLQLAKKEEELQGALARG------DDETLHKNNALKVVRELQAQIAE- 1122
Query: 188 LVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAIN 247
++ F +++ + NK + D + E +K L+ L TK + +
Sbjct: 1123 -LQEDFESEKASRNKAEKQKRDLSEELEALKTELEDT-LDTTAAQQELRTKREQEVAELK 1180
Query: 248 LPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELKESKP 307
LE E A +I + TALE+ E+LE A +K E+ K+
Sbjct: 1181 KALEEETKNHEA---------QIQDMRQRHATALEELSEQLEQA-KRFKANLEKNKQGLE 1230
Query: 308 KNVKEFDI-------LLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENT 360
+ KE + + + ++L ++E + DR+ EL + +LQ E
Sbjct: 1231 TDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELD 1290
Query: 361 SEWDKREILEREKQGLE--RENRRLKIQVKEMEELLDKKNR--LSANSQSPDFKMSQIDL 416
+ E E EK+G++ ++ L+ Q+++ +ELL ++ R L+ +S+ + + L
Sbjct: 1291 NVSTLLE--EAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSL 1348
Query: 417 QEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQN-------EAEVKKLRLRVEELK 469
QE+ +E + A L +Q A ++L +VD + E KKL E L
Sbjct: 1349 QEQQEE---EEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALS 1405
Query: 470 QGLNQKE---DELDDSLNQIRK----LQRSLDEEKERNENLE 504
Q L +K D+L+ + N++++ L LD +++ NLE
Sbjct: 1406 QRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLE 1447
Score = 50.1 bits (118), Expect = 5e-06
Identities = 61/269 (22%), Positives = 116/269 (43%), Gaps = 38/269 (14%)
Query: 241 LRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYE 300
L++K +E E+ E+ L E + IL ++ + T L E E + + L+ K + E
Sbjct: 862 LKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELE 921
Query: 301 ELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQ-NSKDRVICELRAELERLQAEN 359
E+ V+E +E ++ N K++ ++ + + E ++LQ E
Sbjct: 922 EILHDLESRVEE--------EEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEK 973
Query: 360 TSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEK 419
+ K + +E E LE +N + + K ME+ + + +SQ L E+
Sbjct: 974 VTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAE-----CSSQ----------LAEE 1018
Query: 420 NQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDEL 479
++ NL K+ + + I++L E +KK +EL++ + + E
Sbjct: 1019 EEKAKNLA----KIRNKQEVMISDL----------EERLKKEEKTRQELEKAKRKLDGET 1064
Query: 480 DDSLNQIRKLQRSLDEEKERNENLETELR 508
D +QI +LQ +DE K + E EL+
Sbjct: 1065 TDLQDQIAELQAQIDELKLQLAKKEEELQ 1093
Score = 40.4 bits (93), Expect = 0.004
Identities = 31/104 (29%), Positives = 57/104 (54%), Gaps = 14/104 (13%)
Query: 415 DLQEKNQELLNLQHAYYK-------LNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEE 467
+LQ K++ELL ++ K + R++Q + E N +Q +AE + L EE
Sbjct: 853 ELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEE---KNILAEQLQAETE-LFAEAEE 908
Query: 468 LKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRHLQ 511
++ L K+ EL++ L+ L+ ++EE+ERN+ L+ E + +Q
Sbjct: 909 MRARLAAKKQELEEILHD---LESRVEEEEERNQILQNEKKKMQ 949
Score = 39.7 bits (91), Expect = 0.007
Identities = 69/344 (20%), Positives = 137/344 (39%), Gaps = 79/344 (22%)
Query: 76 RELEEVKA-------RAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLE 128
RELEE +A ++ + EK ++ +E+ + R A +E + E
Sbjct: 1659 RELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQE------RDE 1712
Query: 129 MAMKELSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEH--------TDQFQLSSQM 180
+A + ++ K +L +K LEA + Q +EE E D+F+ ++
Sbjct: 1713 LADEITNSASGKSALLDEKRRLEARIAQ-------LEEELEEEQSNMELLNDRFRKTTLQ 1765
Query: 181 HESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTG 240
+++ L + + ++ N ++Q + ++E+K L ++ G K+
Sbjct: 1766 VDTLNAELAAERSAAQKSDNARQQ-----LERQNKELKAKLQELE---------GAVKSK 1811
Query: 241 LRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYE 300
+ ISAL+ + + ++ L +E + R A K + R E
Sbjct: 1812 FK------------ATISALEAKIGQLEEQLEQEAKERAAANKLVRRTE----------- 1848
Query: 301 ELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENT 360
K +KE + Q DE + + KE+ + N++ + +L+ +LE + E T
Sbjct: 1849 -------KKLKE---IFMQVEDERRH-ADQYKEQMEKANARMK---QLKRQLEEAEEEAT 1894
Query: 361 SEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANS 404
R L+RE N L +V ++ L + +S +S
Sbjct: 1895 RANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPISFSS 1938
Score = 33.9 bits (76), Expect = 0.36
Identities = 38/176 (21%), Positives = 83/176 (47%), Gaps = 25/176 (14%)
Query: 340 SKDRVICELRAELERLQAENTSEW---DKREILEREKQGLERENRRLKIQVKEMEELLDK 396
+K + + ++ + E LQA++ +K+ +E E + +ER++++L + + E L
Sbjct: 839 TKVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQA 898
Query: 397 KNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEA 456
+ L A ++ + L K QEL + H ++ + E N++ QNE
Sbjct: 899 ETELFAEAEE-----MRARLAAKKQELEEILH-------DLESRVEE-EEERNQILQNEK 945
Query: 457 EVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRHLQN 512
KK++ +++L E++LD+ +KLQ + + + +E E+ L++
Sbjct: 946 --KKMQAHIQDL-------EEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLED 992
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 86.7 bits (213), Expect = 5e-17
Identities = 104/448 (23%), Positives = 215/448 (47%), Gaps = 47/448 (10%)
Query: 79 EEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAMKE-LSTL 137
EE++ R AQ+++ + A +E K E RQL L A KE +
Sbjct: 839 EELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEI-------RQLEEALVHARKEEKEAV 891
Query: 138 KKKQSLPPQKEALEANVTQDLK----LPGFVEESCEHTDQFQLSSQMHESIREYLVKRQF 193
+++L + EA + N++Q + L ++E E +Q + E+ R +L K
Sbjct: 892 SARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGK--- 948
Query: 194 STKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLENE 253
T E + +V S + E++ LD N E + L+ K LE E
Sbjct: 949 -TIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELA--EMQRQLKEKT----LEAE 1001
Query: 254 VTEISALQVHLDEFQKILWKEREMRTALEKEIER---LESALSLWKWKYE---ELKESKP 307
+ ++A+++ DE + + + R+ + A ++ + + LE L +++ E LK+ +
Sbjct: 1002 KSRLTAMKMQ-DEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRS 1060
Query: 308 KNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWDKRE 367
+ VK+ + D++ +L ++EE + + I R ++E+L+ E E R+
Sbjct: 1061 RLVKQME-------DKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQ 1113
Query: 368 ILEREKQGLERENRRLKIQVKEME-ELLDKKNRLSANSQSPDFKMSQID--LQEKNQELL 424
LE +K LER+N+ LK ++ +E K L ++ ++++++ L+ + ++
Sbjct: 1114 DLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEA---RIAELEDRLESEERDRA 1170
Query: 425 NLQHAYYKLNRQYQANIAELTHAN-NRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSL 483
NLQ + +L R+ + + ++ + + DQ + +L LR++ +K+ + + E+E+D
Sbjct: 1171 NLQLSNRRLERKVKELVMQVDDEHLSLTDQKD----QLSLRLKAMKRQVEEAEEEIDRLE 1226
Query: 484 NQIRKLQRSLDEEKERNENLETELRHLQ 511
+ +KLQR L+E+ + NE+L+ +L ++
Sbjct: 1227 SSKKKLQRELEEQMDMNEHLQGQLNSMK 1254
Score = 62.4 bits (150), Expect = 1e-09
Identities = 90/442 (20%), Positives = 171/442 (38%), Gaps = 87/442 (19%)
Query: 126 KLEMAMKELSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIR 185
K+ + +++ TLK + + Q N T ++K D + S++ +
Sbjct: 577 KVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVK------------DLLEQKSKLTIEVA 624
Query: 186 EYLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGG------------SG 233
E + Q K N KE+ E M+ NL+ + +N
Sbjct: 625 ELQRQLQLEVKNQQNIKEE---------RERMRANLEELRSQHNEKVEENSTLQQRLEES 675
Query: 234 NGETKTGLR-LKAINLPLENEVTEISALQVHLDEFQKIL-----WKEREMRTALEKEIER 287
GE + L L + + E TEI LQ L E L ++RE +E+ ++
Sbjct: 676 EGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQA 735
Query: 288 LESALSLWKWKYEE-----------------LKESKPKNVKEFDILLGQHNDEMQELSGN 330
+ L K E+ LKE + +E D L Q++ E+Q L +
Sbjct: 736 KQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRES 795
Query: 331 IKEESKS---------QNSKDRVICELRAELERLQAENTSEWDKREILEREKQGLERENR 381
++E +K+ + +D+ E+R +L LQ EN + E LER L+R+
Sbjct: 796 VEEATKNVEVLASRSNTSEQDQAGTEMRVKL--LQEENEKLQGRSEELERRVAQLQRQIE 853
Query: 382 RLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANI 441
LK + +E L K + + + + +++ +E ++ + A Q N+
Sbjct: 854 DLKGDEAKAKETLKK-----YEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNL 908
Query: 442 AELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRK------------- 488
++ T ++ + E + + ++ LK + + L ++ +++K
Sbjct: 909 SQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTST 968
Query: 489 --LQRSLDEEKERNENLETELR 508
LQ LDE KE+N E++
Sbjct: 969 LELQNQLDEYKEKNRRELAEMQ 990
Score = 38.9 bits (89), Expect = 0.011
Identities = 47/200 (23%), Positives = 87/200 (43%), Gaps = 33/200 (16%)
Query: 314 DILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWDKREILEREK 373
D+L GQ QEL+ EE+ Q + + + + + ++K + L+
Sbjct: 538 DLLKGQ-----QELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRA 592
Query: 374 QGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYYKL 433
G + N + E+++LL++K++L+ Q+ L+ KNQ+ + +
Sbjct: 593 AGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAE---LQRQLQLEVKNQQNIKEER----- 644
Query: 434 NRQYQANIAEL-THANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRS 492
+ +AN+ EL + N +V++N L+Q L + E EL RK
Sbjct: 645 -ERMRANLEELRSQHNEKVEENST-----------LQQRLEESEGEL-------RKNLEE 685
Query: 493 LDEEKERNENLETELRHLQN 512
L + K E +TE+R LQ+
Sbjct: 686 LFQVKMEREQHQTEIRDLQD 705
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 80.9 bits (198), Expect = 3e-15
Identities = 109/506 (21%), Positives = 222/506 (43%), Gaps = 75/506 (14%)
Query: 71 EELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKL--- 127
E+L L ++E A A ++K R + + W++K+ + +AE ++++E R L +L
Sbjct: 1429 EDLML-DVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKV 1487
Query: 128 ----EMAMKELSTLKKKQSLPPQK------------------EALEANVTQD-LKLPGFV 164
E ++ +L TL+++ Q+ E ++ V Q+ ++ +
Sbjct: 1488 KNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAAL 1547
Query: 165 EE---SCEHTD------QFQLSSQMHESIREYLVK------------RQFSTKEDTNNKE 203
EE S EH + Q +L+ E R+ K R T + T + E
Sbjct: 1548 EEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAE 1607
Query: 204 QGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLP-LENEVTEISALQV 262
D+L++ ++M+ +L+ +++ N + RL A +L N + Q+
Sbjct: 1608 IRSRNDALRVKKKMEGDLNEMEIQLNHAN---------RLAAESLRNYRNTQGILKETQL 1658
Query: 263 HLDEFQKILWKEREMRTALEKEIERLESALS-LWKW-----KYEELKESKPKNVKEFDIL 316
HLD+ + +E +E+ L++ + LW + ++ E + + E L
Sbjct: 1659 HLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQL 1718
Query: 317 LGQHNDEMQELSGNIKEE-SKSQNSKDRVICELRAELERLQAENTSEWDKREILEREKQG 375
L N + ++ + S+ Q+ + VI E R E+ + T E L++E+
Sbjct: 1719 LHTQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDT 1778
Query: 376 ---LERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAY-- 430
LER + L+ VK+++ LD+ +L+ + + ++E E+ N Q
Sbjct: 1779 SAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAE 1838
Query: 431 -YKLNRQYQANIAELTHANNRVDQNEAE----VKKLRLRVEELKQGLNQKEDELDDSLNQ 485
K R+++ + ELT+ +N V KL+ +V+ K+ + E++ + +L++
Sbjct: 1839 AVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSK 1898
Query: 486 IRKLQRSLDEEKERNENLETELRHLQ 511
RKLQ L+E +ER + E+++ L+
Sbjct: 1899 FRKLQHELEEAEERADIAESQVNKLR 1924
Score = 72.0 bits (175), Expect = 1e-12
Identities = 91/451 (20%), Positives = 198/451 (43%), Gaps = 57/451 (12%)
Query: 84 RAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAMKELSTLK----- 138
++A+ EK M A +E++ K + E + + ++L K+ +KE + L+
Sbjct: 844 KSAETEKEM-------ATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQS 896
Query: 139 KKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIREYLVKRQFSTKED 198
+ SL +E E + ++L ++E E ++ + + + + L K+D
Sbjct: 897 EADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKD 956
Query: 199 TNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGET--KTGLRLKAINLPLENEVTE 256
++ E + K+ +E + V +G ET K KA+ + + +
Sbjct: 957 IDDLE----LTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDD 1012
Query: 257 ISA--------------LQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEEL 302
+ A L+ +D+ + L +E+++R LE+ +LE L L + ++
Sbjct: 1013 LQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDM 1072
Query: 303 KESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSE 362
+ K ++ D L + E+ L I++E + + I EL+A +E L E +E
Sbjct: 1073 ENDK----QQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAE 1128
Query: 363 WDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQ- 421
R E+++ L RE ++E+ E L++ ++ +Q++L +K +
Sbjct: 1129 RASRAKAEKQRSDLSRE-------LEEISERLEEAGGATS---------AQVELNKKREA 1172
Query: 422 ELLNLQHAYYKLNRQYQANIAELT--HANNRVDQNEA--EVKKLRLRVEELKQGLNQKED 477
E L+ + Q++A +A L HA++ + E +++++ ++E+ K L + D
Sbjct: 1173 EFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETD 1232
Query: 478 ELDDSLNQIRKLQRSLDEEKERNENLETELR 508
+L + I K + +L++ E+ +EL+
Sbjct: 1233 DLSSNAEAISKAKGNLEKMCRSLEDQVSELK 1263
Score = 59.3 bits (142), Expect = 8e-09
Identities = 96/464 (20%), Positives = 188/464 (40%), Gaps = 71/464 (15%)
Query: 68 DICEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWS-------KVRAERNSAREEG 120
D C EL+ +++++++ A++EK + N E+ + K+ E+ + +E
Sbjct: 948 DECSELK-KDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETH 1006
Query: 121 RQLRIKLEMAMKELSTLKK-KQSLPPQKEALEANVTQDLKL-----------PGFVEESC 168
+Q L+ +++ L K K L Q + LE ++ Q+ KL G ++ +
Sbjct: 1007 QQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQ 1066
Query: 169 EHT-----DQFQLSSQMHESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDG 223
E T D+ QL ++ + +E+ + S ED EQ V I K +E++ ++
Sbjct: 1067 ESTMDMENDKQQLDEKLEK--KEFEISNLISKIED----EQAVEIQLQKKIKELQARIEE 1120
Query: 224 VDLFNNGGSGNGETKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEK 283
+ G E + + + L E+ EIS L+E + E+ E
Sbjct: 1121 L-----GEEIEAERASRAKAEKQRSDLSRELEEISE---RLEEAGGATSAQVELNKKREA 1172
Query: 284 EIERLESALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDR 343
E ++L +L+E+ ++ L +H D M EL I ++ R
Sbjct: 1173 EFQKLR----------RDLEEATLQHEAMVAALRKKHADSMAELGEQI-------DNLQR 1215
Query: 344 VICELRAELERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSAN 403
V +L E L+ E E + + K LE+ R L+ QV E++ +++ RL
Sbjct: 1216 VKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRL--- 1272
Query: 404 SQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRL 463
+ + + LQ + +RQ A ++ + + ++++L+
Sbjct: 1273 ------------INDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKH 1320
Query: 464 RVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETEL 507
++EE + N L S + L+ +EE+E L+ L
Sbjct: 1321 QLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRAL 1364
Score = 51.6 bits (122), Expect = 2e-06
Identities = 106/478 (22%), Positives = 205/478 (42%), Gaps = 74/478 (15%)
Query: 72 ELRLRELEE-VKARAAQMEKTMRWWSDCTANWREKWSKVRAE-RNSAREEGRQLRIKLEM 129
E R LE+ V + E+ R +D TA RA + A E RQL K +
Sbjct: 1249 EKMCRSLEDQVSELKTKEEEQQRLINDLTAQ--------RARLQTEAGEYSRQLDEK-DA 1299
Query: 130 AMKELSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHT--------DQFQLSSQMH 181
+ +LS + KQ+ Q E L+ + ++ K + + + + +Q++ +
Sbjct: 1300 LVSQLS--RSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGK 1357
Query: 182 ESIREYLVKR-----QFSTKEDTNNKEQGVVIDSLK--LSEEMKPNLDGVDLFNNGGSGN 234
++ L K Q+ TK +T+ ++ ++ K L++ ++ + V+ N +
Sbjct: 1358 AELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASL 1417
Query: 235 GETKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSL 294
+TK L+ + +L L+ E + + AL+K+ + LS
Sbjct: 1418 EKTKQRLQNEVEDLMLDVERSNAAC-------------------AALDKKQRNFDKVLSE 1458
Query: 295 WKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQ-NSKDRVICELRAELE 353
WK KYEE + + KE L + E+ ++ N+ EES Q + R L+ E+
Sbjct: 1459 WKQKYEETQAELEASQKESRSL----STELFKVK-NVYEESLDQLETLRRENKNLQQEIS 1513
Query: 354 RLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLD-KKNRLSANSQSPDFKMS 412
L + + LE+ K+ +E+E ++ ++E E L+ ++ ++ + S
Sbjct: 1514 DLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKS 1573
Query: 413 QID--LQEKNQELLNLQHAYYKLNRQYQANI-AELTHANNRV--------DQNEAEVK-- 459
++D + EK++E+ L+ + ++ Q+ + AE+ N+ + D NE E++
Sbjct: 1574 EVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLN 1633
Query: 460 -KLRLRVEELK-----QG-LNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRHL 510
RL E L+ QG L + + LDD+L L+ L + R L+ E+ L
Sbjct: 1634 HANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAEIEEL 1691
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 79.7 bits (195), Expect = 6e-15
Identities = 104/495 (21%), Positives = 212/495 (42%), Gaps = 64/495 (12%)
Query: 77 ELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKL-------EM 129
++E A AA ++K R + A W++K+ + ++E S+++E R L +L E
Sbjct: 1431 DVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEE 1490
Query: 130 AMKELSTLKKKQS----------------------LPPQKEALEANVTQDLKLPGFVEES 167
+++ L T K++ L ++ LEA + E S
Sbjct: 1491 SLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEAS 1550
Query: 168 CEHTDQFQLSSQMHESIREYLVKRQFSTKEDTNNKEQGV---VIDSLKLSEEMKPNLDGV 224
EH + L +Q+ + + ++R+ + K++ + + V+DSL+ S + +
Sbjct: 1551 LEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNE 1610
Query: 225 DLFNNGGSGNGETKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKE 284
L + ++L N ++ +LQ L + Q L L++
Sbjct: 1611 ALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKEN 1670
Query: 285 IERLESALSLWKWKYEELK---ESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSK 341
I +E +L + + EEL+ E ++ K + L + ++ +Q L +
Sbjct: 1671 IAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKM 1730
Query: 342 DRVICELRAELERLQAE--NTSEWDKREI---------LEREKQG---LERENRRLKIQV 387
D + +L+ E+E E N E K+ I L++E+ LER + ++ +
Sbjct: 1731 DADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTI 1790
Query: 388 KEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLN-------RQYQAN 440
K+++ LD+ +++ + L+ + +EL N A K N R+ +
Sbjct: 1791 KDLQHRLDEAEQIALKGGKKQLQK----LEARVRELENELEAEQKRNAESVKGMRKSERR 1846
Query: 441 IAELTHANNRVDQN----EAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEE 496
I ELT+ +N + V KL+L+V+ K+ + E++ + +L++ RK+Q LDE
Sbjct: 1847 IKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEA 1906
Query: 497 KERNENLETELRHLQ 511
+ER + E+++ L+
Sbjct: 1907 EERADIAESQVNKLR 1921
Score = 63.9 bits (154), Expect = 3e-10
Identities = 86/460 (18%), Positives = 200/460 (43%), Gaps = 54/460 (11%)
Query: 84 RAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAMKELSTLK----- 138
++A+ EK M A+ +E++++++ + ++L K+ ++E + L+
Sbjct: 841 KSAEREKEM-------ASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQA 893
Query: 139 KKQSLPPQKEALEANVTQDLKLPGFVEESCEHT-DQFQLSSQMHESIREYLVKRQFSTKE 197
++ +L +E + + ++L V+E E D+ ++++++ R+ L K
Sbjct: 894 EQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRK-LEDECSELKR 952
Query: 198 DTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGE--TKTGLRLKAINLPLENEVT 255
D ++ E + K+ +E + V +G E K KA+ + +
Sbjct: 953 DIDDLE----LTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALD 1008
Query: 256 EISA--------------LQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEE 301
++ A L+ +D+ + L +E+++R LE+ +LE L L + +
Sbjct: 1009 DLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMD 1068
Query: 302 LKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTS 361
L+ K ++ D L + + E+ L+ I++E + + + EL+A +E L+ E +
Sbjct: 1069 LENDK----QQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEA 1124
Query: 362 EWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQ 421
E R +E+ + L RE + +++E + ++ ++ +F+ + DL+E
Sbjct: 1125 ERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREA-EFQKMRRDLEEATL 1183
Query: 422 ELLNLQHAYYKLNRQYQANIAELTHANNRVDQN-EAEVKKLRLRVEELKQGLNQ------ 474
+ A K + A + E RV Q E E + +L ++++ + Q
Sbjct: 1184 QHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKA 1243
Query: 475 --------KEDELDDSLNQIRKLQRSLDEEKERNENLETE 506
ED++++ ++ + QRS+++ + L+TE
Sbjct: 1244 NLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTE 1283
Score = 60.5 bits (145), Expect = 4e-09
Identities = 94/467 (20%), Positives = 186/467 (39%), Gaps = 45/467 (9%)
Query: 78 LEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAMKELST- 136
+E++ A +EK R D R K + + N + R KL+ ELS
Sbjct: 1235 MEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQ----RAKLQTENGELSRQ 1290
Query: 137 LKKKQSLPPQKEALEANVTQ---DLKLPGFVEESCEHTDQFQLSSQMHESIREYLVKRQF 193
L +K++L Q + TQ DLK E ++ L S H+ L++ Q+
Sbjct: 1291 LDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCD---LLREQY 1347
Query: 194 STKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLK-------AI 246
+ + + Q V+ + + + + + + K RL+ A+
Sbjct: 1348 EEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAV 1407
Query: 247 NLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELKESK 306
N + LQ +++ + + AL+K+ + L+ WK KYEE +
Sbjct: 1408 NAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSEL 1467
Query: 307 PKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWDKR 366
+ KE L + E+ +L +E + + R L+ E+ L + S
Sbjct: 1468 ESSQKEARSL----STELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTI 1523
Query: 367 EILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQ----EKNQE 422
LE+ ++ LE E L+ ++E E L+ + +Q +F + +++ EK++E
Sbjct: 1524 HELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQL-EFNQIKAEIERKLAEKDEE 1582
Query: 423 LLNLQHAYYKLNRQYQANIAELTHANNRV---------DQNEAEVK---------KLRLR 464
+ + + ++ Q ++ T + N D NE E++ + + +
Sbjct: 1583 MEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQ 1642
Query: 465 VEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRHLQ 511
V+ L+ L + +LDD++ L+ ++ + RN L+ EL L+
Sbjct: 1643 VKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELR 1689
Score = 55.5 bits (132), Expect = 1e-07
Identities = 111/520 (21%), Positives = 212/520 (40%), Gaps = 88/520 (16%)
Query: 70 CEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEM 129
C++L ++ +++A+ +M + + + A K K+ E + + + L + L
Sbjct: 905 CDQL-IKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAK 963
Query: 130 AMKEL-STLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHT-DQFQLSSQMHESIREY 187
KE +T K ++L + L+ + + K ++E+ + D Q ++ +
Sbjct: 964 VEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKA 1023
Query: 188 LVK--RQFSTKEDTNNKEQGVVID----SLKLSEEMKPNLDGVDLFNNGGSGNGET--KT 239
VK +Q E + +E+ V +D KL ++K + + N E K
Sbjct: 1024 KVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKK 1083
Query: 240 GLRLKAINLPLENEVT-------EISALQVHLDEFQKILWKEREMRTALEK--------- 283
L A+N +E+E ++ LQ ++E ++ L ER R +EK
Sbjct: 1084 DFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSREL 1143
Query: 284 -EI-ERLESALSLWKWKYE--------------ELKESKPKNVKEFDILLGQHNDEMQEL 327
EI ERLE A + E +L+E+ ++ L +H D + EL
Sbjct: 1144 EEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAEL 1203
Query: 328 SGNI-----------KEESKSQNSKDRV------ICELRAELERL---------QAENTS 361
I KE+S+ + D V I + +A LE++ + + +
Sbjct: 1204 GEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKA 1263
Query: 362 EWDKREI--LEREKQGLERENRRLKIQVKEMEELLDK--KNRLSANSQSPDFKMS-QIDL 416
E +R + L ++ L+ EN L Q+ E E L+ + + +L+ Q D K + ++
Sbjct: 1264 EETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEV 1323
Query: 417 QEKN---QELLNLQHAYYKLNRQYQANIAE-------LTHANNRVDQ----NEAEVKKLR 462
+ KN L + +H L QY+ L+ AN+ V Q E + +
Sbjct: 1324 KAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRT 1383
Query: 463 LRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNEN 502
+EE K+ L Q+ E ++++ + SL++ K R +N
Sbjct: 1384 EELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQN 1423
Score = 41.6 bits (96), Expect = 0.002
Identities = 62/307 (20%), Positives = 125/307 (40%), Gaps = 53/307 (17%)
Query: 204 QGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLENEVTEISALQVH 263
+G IDS K +E++ +LD ++ G TK + + L E +S +
Sbjct: 732 EGQFIDSRKGAEKLLSSLD----IDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIITR 787
Query: 264 LDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELKESKPKNVKEFDILLGQHNDE 323
+ + + E + LE+ +L + +W N++ F +G N
Sbjct: 788 IQAQSRGVLARMEYKKLLERR-----DSLLVIQW-----------NIRAF---MGVKNWP 828
Query: 324 MQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWDKREILEREKQGLERENRRL 383
+L IK KS +++ + ++ E RL K+ LE+ R
Sbjct: 829 WMKLYFKIKPLLKSAE-REKEMASMKEEFTRL-----------------KEALEKSEARR 870
Query: 384 KIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAE 443
K ++M LL +KN L Q+ ++ D +E+ +L+ K Q +A + E
Sbjct: 871 KELEEKMVSLLQEKNDLQLQVQAEQDNLA--DAEERCDQLI-------KNKIQLEAKVKE 921
Query: 444 LTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENL 503
+ N R++ E +L + +L+ ++ + ++DD + K+++ + + +NL
Sbjct: 922 M---NERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNL 978
Query: 504 ETELRHL 510
E+ L
Sbjct: 979 TEEMAGL 985
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 79.3 bits (194), Expect = 8e-15
Identities = 106/462 (22%), Positives = 197/462 (42%), Gaps = 69/462 (14%)
Query: 71 EELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMA 130
EE+ +E E VK R Q+ R T S++ AE+ +E+ Q +L
Sbjct: 845 EEMMAKEEELVKVREKQLAAENRLTEMETLQ-----SQLMAEKLQLQEQ-LQAETELCAE 898
Query: 131 MKELST--LKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMH------- 181
+EL KKQ L LEA V ++ EE C+H + Q +
Sbjct: 899 AEELRARLTAKKQELEEICHDLEARVEEE-------EERCQHLQAEKKKMQQNIQELEEQ 951
Query: 182 ----ESIREYLVKRQFSTKEDTNNKEQGVVI---DSLKLSEEMKPNLDGVDLFNNGGSGN 234
ES R+ L + +T+ E+ +I + KL++E K D + F +
Sbjct: 952 LEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEE 1011
Query: 235 GETKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSL 294
E L L+N+ + + + ++ L +E + R LEK +LE +
Sbjct: 1012 EEKSKSLA------KLKNKH------EAMITDLEERLRREEKQRQELEKTRRKLEGDSTD 1059
Query: 295 WKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELER 354
+ EL+ + E + L + +E+Q ++EE+ +N + I EL +++
Sbjct: 1060 LSDQIAELQAQ----IAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISE 1115
Query: 355 LQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQI 414
LQ + SE R E++K+ L E LK E+E+ LD +Q
Sbjct: 1116 LQEDLESERASRNKAEKQKRDLGEELEALK---TELEDTLDS-------------TAAQQ 1159
Query: 415 DLQEKNQELLN-LQHAYYKLNRQYQANIAELTHANNRVDQNEAE----VKKLRLRVEELK 469
+L+ K ++ +N L+ + + ++A I E+ +++ + AE K+++ +E+ K
Sbjct: 1160 ELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAK 1219
Query: 470 QGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRHLQ 511
Q L + EL N+++ L + + + + + +E +L+ LQ
Sbjct: 1220 QTLENERGEL---ANEVKVLLQGKGDSEHKRKKVEAQLQELQ 1258
Score = 70.5 bits (171), Expect = 4e-12
Identities = 95/464 (20%), Positives = 199/464 (42%), Gaps = 55/464 (11%)
Query: 75 LRELEEVKARAAQMEKTMRWWSDCTANWREKWSK----VRAERNSAREEGRQLRIKLEMA 130
L E E KA ++ K R + + ++ K + + + ++ +++ +LE
Sbjct: 1485 LEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEEL 1544
Query: 131 MKEL-STLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQF-----QLSSQMHESI 184
EL +T K L +A++A +DL+ G E+S E Q ++ +++ +
Sbjct: 1545 EDELQATEDAKLRLEVNLQAMKAQFERDLQ--GRDEQSEEKKKQLVRQVREMEAELEDER 1602
Query: 185 REYLV------KRQFSTKE-----DTNNKEQGVVIDSL-KLSEEMKPNLDGVDLFNNGGS 232
++ + K + K+ D+ NK + I L KL +MK + +D
Sbjct: 1603 KQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELD------- 1655
Query: 233 GNGETKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESAL 292
+T+ R + + ENE ++ +++ + + Q+ L + ++E + L +
Sbjct: 1656 ---DTRAS-REEILAQAKENE-KKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEI 1710
Query: 293 SLWKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGN---IKEESKSQNSK-DRVICEL 348
+ K E K + + + Q +E++E GN I + K N + D++ +L
Sbjct: 1711 ANSSGKGALALEEK----RRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDL 1766
Query: 349 RAELERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPD 408
LER A+ E +Q LER+N+ LK++++EME + K + S +
Sbjct: 1767 N--LERSHAQKN---------ENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAK 1815
Query: 409 FKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEEL 468
+ L + +E + ++ + + ++ +Q + + K R+++L
Sbjct: 1816 IAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQL 1875
Query: 469 KQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRHLQN 512
K+ L + E+E + RKLQR L++ E + + E+ L+N
Sbjct: 1876 KRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKN 1919
Score = 69.3 bits (168), Expect = 8e-12
Identities = 98/441 (22%), Positives = 189/441 (42%), Gaps = 40/441 (9%)
Query: 79 EEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAMKELSTLK 138
++V+A+ +++ +K +K++ E ++ Q K K+ S L+
Sbjct: 1248 KKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALE 1307
Query: 139 KKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIREYLVKRQFSTKED 198
+ L +E L+ Q L L +++ + + F+ + E + L K+ +
Sbjct: 1308 SQ--LQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQ 1365
Query: 199 TNN--KEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLENEVTE 256
+ K+ + L+ +EE+K L DL G S E K K LE T
Sbjct: 1366 VADMKKKMEDSVGCLETAEEVKRKLQK-DL--EGLSQRHEEKVAAYDK-----LEKTKTR 1417
Query: 257 ISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKW---KYEELKESKPKNVKEF 313
LQ LD+ L +R+ LEK+ ++ + L+ K KY E ++ +E
Sbjct: 1418 ---LQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREK 1474
Query: 314 DILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWDKREILEREK 373
+ + L+ ++E + + +R+ + R E+E L + LE+ K
Sbjct: 1475 ET-------KALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSK 1527
Query: 374 QGLERENRRLKIQVKEMEELL----DKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHA 429
+ LE++ +K Q++E+E+ L D K RL N Q+ + + DLQ ++++ +
Sbjct: 1528 RALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFER-DLQGRDEQ---SEEK 1583
Query: 430 YYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKL 489
+L RQ + AEL + A KKL + +++L+ ++ D+++ Q+RKL
Sbjct: 1584 KKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKL 1643
Query: 490 Q-------RSLDEEKERNENL 503
Q R LD+ + E +
Sbjct: 1644 QAQMKDCMRELDDTRASREEI 1664
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 79.3 bits (194), Expect = 8e-15
Identities = 107/512 (20%), Positives = 222/512 (43%), Gaps = 87/512 (16%)
Query: 71 EELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKL--- 127
E+L L ++E A A ++K R + A W++K + AE ++++E R L +L
Sbjct: 1432 EDLML-DVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKI 1490
Query: 128 ----EMAMKELSTLKKKQSLPPQK------------------EALEANVTQD-LKLPGFV 164
E ++ +L TLK++ Q+ E ++ V Q+ +L +
Sbjct: 1491 KNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAAL 1550
Query: 165 EE---SCEHTD------QFQLSSQMHESIREYLVK------------RQFSTKEDTNNKE 203
EE S EH + Q +L+ E R+ K R + + T + E
Sbjct: 1551 EEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAE 1610
Query: 204 QGVVIDSLKLSEEMKPNLDGVDL-FNNGGSGNGETKTGLR-----LKAINLPLENEVTE- 256
D+++L ++M+ +L+ +++ N+ E R LK + L++ +
Sbjct: 1611 IRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQ 1670
Query: 257 -------------ISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELK 303
+ LQ ++E + L + R E+E+ + L + L
Sbjct: 1671 EDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLI 1730
Query: 304 ESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEW 363
+K K + + G+ D +QE + N +E++K + ++ E E E
Sbjct: 1731 NTKKKLETDISQMQGEMEDILQE-ARNAEEKAKKAITDAAMMAE----------ELKKEQ 1779
Query: 364 DKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQEL 423
D LER K+ +E+ + L++++ E E+L K + Q + ++ +++ + ++++
Sbjct: 1780 DTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQI--QKLEARVRELEGEVESEQK 1837
Query: 424 LNLQHAYYKLNRQYQANIAELTHANNRVDQN----EAEVKKLRLRVEELKQGLNQKEDEL 479
N + K R+++ + ELT+ +N + V KL+ +V+ K+ + E++
Sbjct: 1838 RNAEAV--KGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQS 1895
Query: 480 DDSLNQIRKLQRSLDEEKERNENLETELRHLQ 511
+ +L + RKLQ L+E +ER + E+++ L+
Sbjct: 1896 NTNLAKFRKLQHELEEAEERADIAESQVNKLR 1927
Score = 66.6 bits (161), Expect = 5e-11
Identities = 87/449 (19%), Positives = 202/449 (44%), Gaps = 53/449 (11%)
Query: 84 RAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAMKELSTLK----- 138
++A+ EK M A +E++ K++ E + + ++L K+ +KE + L+
Sbjct: 847 KSAETEKEM-------ATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQA 899
Query: 139 KKQSLPPQKEALEANVTQDLKLPGFVEESCEHT-DQFQLSSQMHESIREYLVKRQFSTKE 197
+ + L +E + + ++L ++E E D+ ++++++ R+ L K+
Sbjct: 900 EAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRK-LEDECSELKK 958
Query: 198 DTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGET--KTGLRLKAINLPLENEVT 255
D ++ E + K+ +E + V +G ET K KA+ + +
Sbjct: 959 DIDDLE----LTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLD 1014
Query: 256 EISA--------------LQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEE 301
++ A L+ +D+ + L +E+++R LE+ +LE L L + +
Sbjct: 1015 DLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMD 1074
Query: 302 LKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTS 361
++ K ++ D L + E+ L I++E + I EL+A +E L+ E +
Sbjct: 1075 IENEK----QQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEA 1130
Query: 362 EWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQ 421
E R E+++ L RE + +++E + ++ ++ +F+ + DL+E
Sbjct: 1131 ERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREA-EFQKMRRDLEEAT- 1188
Query: 422 ELLNLQH--AYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDEL 479
LQH L +++ ++AEL ++D +++++ ++E+ K + + D+L
Sbjct: 1189 ----LQHEATAATLRKKHADSVAEL---GEQIDN----LQRVKQKLEKEKSEMKMEIDDL 1237
Query: 480 DDSLNQIRKLQRSLDEEKERNENLETELR 508
++ + K + +L++ E+ +EL+
Sbjct: 1238 ASNVETVSKAKGNLEKMCRTLEDQLSELK 1266
Score = 64.3 bits (155), Expect = 3e-10
Identities = 97/473 (20%), Positives = 196/473 (41%), Gaps = 70/473 (14%)
Query: 77 ELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAER-NSAREEGRQLRIKLEMAMKELS 135
++E K R A+ +K R + T + +R + +S E G Q+ L+ ++L
Sbjct: 1166 QIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQID-NLQRVKQKLE 1224
Query: 136 TLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIREYLVKRQFST 195
K+K + + + L +NV K G +E+ C T + QLS + + + +
Sbjct: 1225 --KEKSEMKMEIDDLASNVETVSKAKGNLEKMCR-TLEDQLSELKSKEEEQQRLINDLTA 1281
Query: 196 KEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLENEVT 255
+ E G L E + L G+ +++ + LE E+
Sbjct: 1282 QRGRLQTESGEFSRQLDEKEALVSQLS-----------RGKQAFTQQIEELKRQLEEEIK 1330
Query: 256 EISALQVHL-------DEFQKILWKEREMRTALEKEIERLESALSLWKWKY--------E 300
+AL L D ++ +E+E + L++ + + + ++ W+ KY E
Sbjct: 1331 AKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTE 1390
Query: 301 ELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENT 360
EL+E+K K + L + ++ ++ K++ + +L ++ER A
Sbjct: 1391 ELEEAKKKLAQR----LQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAA-C 1445
Query: 361 SEWDKRE-----ILEREKQGLERENRRLKIQVKE--------------MEELLDKKNRLS 401
+ DK++ IL KQ E + L+ KE EE LD+ L
Sbjct: 1446 AALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLK 1505
Query: 402 ANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAE----LTHANNRVDQNEAE 457
+++ ++S DL E+ E H K+ +Q + E L A ++ E +
Sbjct: 1506 RENKNLQQEIS--DLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGK 1563
Query: 458 VKKLRLRVEELKQGLNQKEDELDDSLNQIRK--------LQRSLDEE-KERNE 501
+ +++L + ++K +++K E D+ ++Q+++ +Q +LD E + RN+
Sbjct: 1564 ILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRND 1616
Score = 57.8 bits (138), Expect = 2e-08
Identities = 102/502 (20%), Positives = 205/502 (40%), Gaps = 90/502 (17%)
Query: 68 DICEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWS-------KVRAERNSAREEG 120
D C EL+ +++++++ A++EK + N E+ + K+ E+ + +E
Sbjct: 951 DECSELK-KDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAH 1009
Query: 121 RQLRIKLEMAMKELSTLKK-KQSLPPQKEALEANVTQDLKLPGFVEESCEHTD-QFQLSS 178
+Q L+ +++TL K K L Q + LE ++ Q+ KL +E + + +L+
Sbjct: 1010 QQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQ 1069
Query: 179 QM-------HESIREYLVKRQF--STKEDTNNKEQGVVIDSLKLSEEMKPNLDGVD---- 225
+ + + E L K++F S + EQ + I K +E++ ++ ++
Sbjct: 1070 ESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIE 1129
Query: 226 --------------------------LFNNGGSGNGETKTGLRLKAI---------NLPL 250
L GG+ + + + + +A L
Sbjct: 1130 AERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATL 1189
Query: 251 ENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELKESKPKNV 310
++E T + + H D ++ E L++ ++LE S K + ++L NV
Sbjct: 1190 QHEATAATLRKKHADSVAEL----GEQIDNLQRVKQKLEKEKSEMKMEIDDLAS----NV 1241
Query: 311 KEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAEN---TSEWDKRE 367
+ G + L + E + + R+I +L A+ RLQ E+ + + D++E
Sbjct: 1242 ETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKE 1301
Query: 368 IL----EREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSP--DFKMSQIDLQEKNQ 421
L R KQ ++ LK +++EE + KN L+ QS D + + +E+ +
Sbjct: 1302 ALVSQLSRGKQAFTQQIEELK---RQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQE 1358
Query: 422 ELLNLQHAYYKLNRQY-QANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELD 480
LQ A K N + Q T A R ++ +EE K+ L Q+ +
Sbjct: 1359 SKAELQRALSKANTEVAQWRTKYETDAIQRTEE-----------LEEAKKKLAQRLQAAE 1407
Query: 481 DSLNQIRKLQRSLDEEKERNEN 502
+ + + SL++ K+R +N
Sbjct: 1408 EHVEAVNAKCASLEKTKQRLQN 1429
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 79.3 bits (194), Expect = 8e-15
Identities = 107/512 (20%), Positives = 222/512 (43%), Gaps = 87/512 (16%)
Query: 71 EELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKL--- 127
E+L L ++E A A ++K R + A W++K + AE ++++E R L +L
Sbjct: 1432 EDLML-DVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKI 1490
Query: 128 ----EMAMKELSTLKKKQSLPPQK------------------EALEANVTQD-LKLPGFV 164
E ++ +L TLK++ Q+ E ++ V Q+ +L +
Sbjct: 1491 KNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAAL 1550
Query: 165 EE---SCEHTD------QFQLSSQMHESIREYLVK------------RQFSTKEDTNNKE 203
EE S EH + Q +L+ E R+ K R + + T + E
Sbjct: 1551 EEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAE 1610
Query: 204 QGVVIDSLKLSEEMKPNLDGVDL-FNNGGSGNGETKTGLR-----LKAINLPLENEVTE- 256
D+++L ++M+ +L+ +++ N+ E R LK + L++ +
Sbjct: 1611 IRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQ 1670
Query: 257 -------------ISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELK 303
+ LQ ++E + L + R E+E+ + L + L
Sbjct: 1671 EDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLI 1730
Query: 304 ESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEW 363
+K K + + G+ D +QE + N +E++K + ++ E E E
Sbjct: 1731 NTKKKLETDISQMQGEMEDILQE-ARNAEEKAKKAITDAAMMAE----------ELKKEQ 1779
Query: 364 DKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQEL 423
D LER K+ +E+ + L++++ E E+L K + Q + ++ +++ + ++++
Sbjct: 1780 DTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQI--QKLEARVRELEGEVESEQK 1837
Query: 424 LNLQHAYYKLNRQYQANIAELTHANNRVDQN----EAEVKKLRLRVEELKQGLNQKEDEL 479
N + K R+++ + ELT+ +N + V KL+ +V+ K+ + E++
Sbjct: 1838 RNAEAV--KGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQS 1895
Query: 480 DDSLNQIRKLQRSLDEEKERNENLETELRHLQ 511
+ +L + RKLQ L+E +ER + E+++ L+
Sbjct: 1896 NTNLAKFRKLQHELEEAEERADIAESQVNKLR 1927
Score = 66.6 bits (161), Expect = 5e-11
Identities = 87/449 (19%), Positives = 202/449 (44%), Gaps = 53/449 (11%)
Query: 84 RAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAMKELSTLK----- 138
++A+ EK M A +E++ K++ E + + ++L K+ +KE + L+
Sbjct: 847 KSAETEKEM-------ATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQA 899
Query: 139 KKQSLPPQKEALEANVTQDLKLPGFVEESCEHT-DQFQLSSQMHESIREYLVKRQFSTKE 197
+ + L +E + + ++L ++E E D+ ++++++ R+ L K+
Sbjct: 900 EAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRK-LEDECSELKK 958
Query: 198 DTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGET--KTGLRLKAINLPLENEVT 255
D ++ E + K+ +E + V +G ET K KA+ + +
Sbjct: 959 DIDDLE----LTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLD 1014
Query: 256 EISA--------------LQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEE 301
++ A L+ +D+ + L +E+++R LE+ +LE L L + +
Sbjct: 1015 DLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMD 1074
Query: 302 LKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTS 361
++ K ++ D L + E+ L I++E + I EL+A +E L+ E +
Sbjct: 1075 IENEK----QQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEA 1130
Query: 362 EWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQ 421
E R E+++ L RE + +++E + ++ ++ +F+ + DL+E
Sbjct: 1131 ERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREA-EFQKMRRDLEEAT- 1188
Query: 422 ELLNLQH--AYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDEL 479
LQH L +++ ++AEL ++D +++++ ++E+ K + + D+L
Sbjct: 1189 ----LQHEATAATLRKKHADSVAEL---GEQIDN----LQRVKQKLEKEKSEMKMEIDDL 1237
Query: 480 DDSLNQIRKLQRSLDEEKERNENLETELR 508
++ + K + +L++ E+ +EL+
Sbjct: 1238 ASNVETVSKAKGNLEKMCRTLEDQLSELK 1266
Score = 64.3 bits (155), Expect = 3e-10
Identities = 97/473 (20%), Positives = 196/473 (41%), Gaps = 70/473 (14%)
Query: 77 ELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAER-NSAREEGRQLRIKLEMAMKELS 135
++E K R A+ +K R + T + +R + +S E G Q+ L+ ++L
Sbjct: 1166 QIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQID-NLQRVKQKLE 1224
Query: 136 TLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIREYLVKRQFST 195
K+K + + + L +NV K G +E+ C T + QLS + + + +
Sbjct: 1225 --KEKSEMKMEIDDLASNVETVSKAKGNLEKMCR-TLEDQLSELKSKEEEQQRLINDLTA 1281
Query: 196 KEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLENEVT 255
+ E G L E + L G+ +++ + LE E+
Sbjct: 1282 QRGRLQTESGEFSRQLDEKEALVSQLS-----------RGKQAFTQQIEELKRQLEEEIK 1330
Query: 256 EISALQVHL-------DEFQKILWKEREMRTALEKEIERLESALSLWKWKY--------E 300
+AL L D ++ +E+E + L++ + + + ++ W+ KY E
Sbjct: 1331 AKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTE 1390
Query: 301 ELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENT 360
EL+E+K K + L + ++ ++ K++ + +L ++ER A
Sbjct: 1391 ELEEAKKKLAQR----LQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAA-C 1445
Query: 361 SEWDKRE-----ILEREKQGLERENRRLKIQVKE--------------MEELLDKKNRLS 401
+ DK++ IL KQ E + L+ KE EE LD+ L
Sbjct: 1446 AALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLK 1505
Query: 402 ANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAE----LTHANNRVDQNEAE 457
+++ ++S DL E+ E H K+ +Q + E L A ++ E +
Sbjct: 1506 RENKNLQQEIS--DLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGK 1563
Query: 458 VKKLRLRVEELKQGLNQKEDELDDSLNQIRK--------LQRSLDEE-KERNE 501
+ +++L + ++K +++K E D+ ++Q+++ +Q +LD E + RN+
Sbjct: 1564 ILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRND 1616
Score = 57.8 bits (138), Expect = 2e-08
Identities = 102/502 (20%), Positives = 205/502 (40%), Gaps = 90/502 (17%)
Query: 68 DICEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWS-------KVRAERNSAREEG 120
D C EL+ +++++++ A++EK + N E+ + K+ E+ + +E
Sbjct: 951 DECSELK-KDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAH 1009
Query: 121 RQLRIKLEMAMKELSTLKK-KQSLPPQKEALEANVTQDLKLPGFVEESCEHTD-QFQLSS 178
+Q L+ +++TL K K L Q + LE ++ Q+ KL +E + + +L+
Sbjct: 1010 QQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQ 1069
Query: 179 QM-------HESIREYLVKRQF--STKEDTNNKEQGVVIDSLKLSEEMKPNLDGVD---- 225
+ + + E L K++F S + EQ + I K +E++ ++ ++
Sbjct: 1070 ESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIE 1129
Query: 226 --------------------------LFNNGGSGNGETKTGLRLKAI---------NLPL 250
L GG+ + + + + +A L
Sbjct: 1130 AERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATL 1189
Query: 251 ENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELKESKPKNV 310
++E T + + H D ++ E L++ ++LE S K + ++L NV
Sbjct: 1190 QHEATAATLRKKHADSVAEL----GEQIDNLQRVKQKLEKEKSEMKMEIDDLAS----NV 1241
Query: 311 KEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAEN---TSEWDKRE 367
+ G + L + E + + R+I +L A+ RLQ E+ + + D++E
Sbjct: 1242 ETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKE 1301
Query: 368 IL----EREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSP--DFKMSQIDLQEKNQ 421
L R KQ ++ LK +++EE + KN L+ QS D + + +E+ +
Sbjct: 1302 ALVSQLSRGKQAFTQQIEELK---RQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQE 1358
Query: 422 ELLNLQHAYYKLNRQY-QANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELD 480
LQ A K N + Q T A R ++ +EE K+ L Q+ +
Sbjct: 1359 SKAELQRALSKANTEVAQWRTKYETDAIQRTEE-----------LEEAKKKLAQRLQAAE 1407
Query: 481 DSLNQIRKLQRSLDEEKERNEN 502
+ + + SL++ K+R +N
Sbjct: 1408 EHVEAVNAKCASLEKTKQRLQN 1429
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 79.0 bits (193), Expect = 1e-14
Identities = 103/513 (20%), Positives = 217/513 (42%), Gaps = 100/513 (19%)
Query: 77 ELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKL-------EM 129
++E A ++K R + A W++K+ + +AE ++++E R L +L E
Sbjct: 1435 DVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEE 1494
Query: 130 AMKELSTLKK-----------------------------KQSLPPQKEALEANVTQDLKL 160
++ L TLK+ K+ L +K L+ ++ +
Sbjct: 1495 SLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEE---- 1550
Query: 161 PGFVEESCEHTD------QFQLSSQMHESIREYLVK------------RQFSTKEDTNNK 202
E S EH + Q +L+ E R+ K R + + T +
Sbjct: 1551 ---AEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDA 1607
Query: 203 EQGVVIDSLKLSEEMKPNLDGVDL-FNNGGSGNGETKTGLR-----LKAINLPLENEVT- 255
E D+L++ ++M+ +L+ +++ N+ E LR LK L L++ +
Sbjct: 1608 EIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRG 1667
Query: 256 -------------EISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEEL 302
+ +Q ++E + L + R E+E+ + L + L
Sbjct: 1668 QDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSL 1727
Query: 303 KESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSE 362
+K K + + G+ D +QE + N +E++K + ++ E E E
Sbjct: 1728 INTKKKLETDISQIQGEMEDIVQE-ARNAEEKAKKAITDAAMMAE----------ELKKE 1776
Query: 363 WDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQE 422
D LER K+ +E+ + L++++ E E+L K + Q + ++ +++ + ++++
Sbjct: 1777 QDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQI--QKLEARVRELESEVESEQ 1834
Query: 423 LLNLQHAYYKLNRQYQANIAELTHANNRVDQN----EAEVKKLRLRVEELKQGLNQKEDE 478
N++ K R+++ + ELT+ +N + V KL+ +V+ K+ + E++
Sbjct: 1835 KHNVEAV--KGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAEEAEEQ 1892
Query: 479 LDDSLNQIRKLQRSLDEEKERNENLETELRHLQ 511
+ +L + RKLQ L+E KER + E+++ L+
Sbjct: 1893 SNVNLAKFRKLQHELEEAKERADIAESQVNKLR 1925
Score = 62.0 bits (149), Expect = 1e-09
Identities = 48/236 (20%), Positives = 110/236 (46%), Gaps = 9/236 (3%)
Query: 273 KEREMRTALEKEIERLESALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIK 332
K +E+ E E E + + L+ K K E+ K++ + ++ L + E +K
Sbjct: 922 KIKEVTERAEDE-EEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVK 980
Query: 333 EESKSQNSKDRVICELRAELERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEE 392
++ D I +L E + LQ + D ++ E + L + +L+ QV ++E
Sbjct: 981 NLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEG 1040
Query: 393 LLDKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVD 452
L+++ +L + + K+ DL+ + ++ ++ +LN + + E+++ +++
Sbjct: 1041 SLEQEKKLCMDLERAKRKLEG-DLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIE 1099
Query: 453 QNEAEVKKLRLRVEELKQGLNQKEDELD-------DSLNQIRKLQRSLDEEKERNE 501
+A +L+ +++EL+ + + E+E++ + Q L R L+E ER E
Sbjct: 1100 DEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLE 1155
Score = 56.6 bits (135), Expect = 5e-08
Identities = 110/513 (21%), Positives = 206/513 (40%), Gaps = 112/513 (21%)
Query: 68 DICEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWS-------KVRAERNSAREEG 120
D C EL+ +++++++ A++EK + N E+ + K+ E+ + +E
Sbjct: 949 DECSELK-KDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAH 1007
Query: 121 RQLRIKLEMAMKELSTLKK-KQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQ 179
+Q L+M +++TL K K L Q + LE ++ Q+ KL +E +
Sbjct: 1008 QQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERA------------ 1055
Query: 180 MHESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKT 239
+ L Q ST + N+K+Q L+E++K ++ N G E
Sbjct: 1056 -KRKLEGDLKLAQESTMDTENDKQQ--------LNEKLKKK--EFEMSNLQGKIEDE--- 1101
Query: 240 GLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKE-----------IERL 288
+A+ + L+ ++ E LQ ++E ++ + ER R EK+ ERL
Sbjct: 1102 ----QALAIQLQKKIKE---LQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERL 1154
Query: 289 ESALSLWKWKYE--------------ELKESKPKNVKEFDILLGQHNDEMQELSGNIKEE 334
E A + E +L+ES ++ L +H D + EL I
Sbjct: 1155 EEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSL 1214
Query: 335 SKSQNSKDRVICELRAELERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEELL 394
+ + ++ EL+ E+ L + + + E+ + LE + +K + +E + L+
Sbjct: 1215 QRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLI 1274
Query: 395 D----KKNRLSANS-------QSPDFKMSQI----------------DLQEKNQELLNLQ 427
+ +K RL S D +SQ+ L+E+ + L
Sbjct: 1275 NELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLA 1334
Query: 428 HAYYK-------LNRQY---QANIAEL----THANNRVDQ----NEAEVKKLRLRVEELK 469
HA L QY Q AEL + AN+ V Q E + + +EE K
Sbjct: 1335 HALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAK 1394
Query: 470 QGLNQKEDELDDSLNQIRKLQRSLDEEKERNEN 502
+ L Q+ + ++ + + SL++ K+R +N
Sbjct: 1395 KKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQN 1427
Score = 50.1 bits (118), Expect = 5e-06
Identities = 105/524 (20%), Positives = 206/524 (39%), Gaps = 110/524 (20%)
Query: 78 LEEVKARAAQMEKTMRWWSDCTANWREKW-------SKVRAERNSAREEGRQLRIKLEMA 130
+E V A EK R D + + K +++ A++ E + +L+
Sbjct: 1239 METVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEK 1298
Query: 131 MKELSTLKK-KQSLPPQKEALEANVTQDLKLPGFVE---ESCEHT-----DQFQLSSQMH 181
+S L + KQ+ Q E L+ + ++ K + +S H +Q++ +
Sbjct: 1299 DAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAK 1358
Query: 182 ESIREYLVKR-----QFSTKEDTNNKEQGVVIDSLK--LSEEMKPNLDGVDLFNNGGSGN 234
++ + K Q+ TK +T+ ++ ++ K L++ ++ + V+ N+ +
Sbjct: 1359 AELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASL 1418
Query: 235 GETKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSL 294
+TK L+ + +L ++ E + + + AL+K+ + L+
Sbjct: 1419 EKTKQRLQNEVEDLMIDVERSNAACI-------------------ALDKKQRNFDKVLAE 1459
Query: 295 WKWKYEEL--------KES--------KPKNVKE-----FDILLGQHNDEMQELSG---- 329
WK KYEE KES K KN E + L ++ + QE+S
Sbjct: 1460 WKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQ 1519
Query: 330 ------NIKEESKSQNSKDRVICELRAELERLQAENTSEWDK----------------RE 367
+I E K + D EL+ LE +A E K R+
Sbjct: 1520 IAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRK 1579
Query: 368 ILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANS------QSPDFKMSQIDLQEKNQ 421
I E++++ + + L++ V+ M+ LD + R ++ D +I L N+
Sbjct: 1580 IAEKDEELDQLKRNHLRV-VESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANR 1638
Query: 422 E----LLNLQHAYYKL-NRQYQANIA---------ELTHANNRVDQNEAEVKKLRLRVEE 467
+ L NL++ L + Q + A +L R + +AEV++LR +E
Sbjct: 1639 QAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLER 1698
Query: 468 LKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRHLQ 511
++G E EL D+ +++ L + LET++ +Q
Sbjct: 1699 TERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQ 1742
Score = 40.4 bits (93), Expect = 0.004
Identities = 36/170 (21%), Positives = 86/170 (50%), Gaps = 7/170 (4%)
Query: 342 DRVICELRAELERLQAENTSEWDKREILEREKQGLERENRRLKIQVK-EMEELLDKKNR- 399
++ + ++ E E+ + E KR+ LE + L +E L++QV+ E + L D + R
Sbjct: 850 EKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAEERC 909
Query: 400 --LSANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAE 457
L + K+ ++ + +++E +N + K R+ + +EL + ++ A+
Sbjct: 910 DQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKK--RKLEDECSELKKDIDDLELTLAK 967
Query: 458 VKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERN-ENLETE 506
V+K + E + L ++ LD+++ ++ K +++L E ++ ++L+ E
Sbjct: 968 VEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQME 1017
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 77.4 bits (189), Expect = 3e-14
Identities = 104/494 (21%), Positives = 220/494 (44%), Gaps = 62/494 (12%)
Query: 77 ELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKL-------EM 129
++E A A ++K R + A W++K + AE ++++E R L +L E
Sbjct: 1435 DVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEE 1494
Query: 130 AMKELSTLKKKQSLPPQK------------------EALEANVTQDL-KLPGFVEE---S 167
++ +L TLK++ Q+ E ++ V Q+ +L +EE S
Sbjct: 1495 SLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEAS 1554
Query: 168 CEHTDQFQLSSQMHESIREYLVKRQFSTKE---DTNNKEQGVVIDSLK--LSEEMKPNLD 222
EH + L Q+ + + V R+ + K+ D + +++S++ L E++ D
Sbjct: 1555 LEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRND 1614
Query: 223 GVDLFNNGGSGNGETKTGL----RLKAINLP-LENEVTEISALQVHLDEFQKILWKEREM 277
+ L E + L R+ A L N + Q+HLD+ + +E
Sbjct: 1615 AIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQ 1674
Query: 278 RTALEK-------EIERLESALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGN 330
+E+ EIE L + L + + ++ E + + E LL N +
Sbjct: 1675 LAMVERRANLLQAEIEELRATLEQTE-RSRKIAEQELLDASERVQLLHTQNTSLINTKKK 1733
Query: 331 IKEE-SKSQNSKDRVICELRAELERLQAENTSEWDKREILEREKQG---LERENRRLKIQ 386
++ + S+ Q + +I E R E+ + T E L++E+ LER + L+
Sbjct: 1734 LETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQT 1793
Query: 387 VKEMEELLDKKNRLSANS-----QSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANI 441
VK+++ LD+ +L+ Q + ++ +++ + ++++ N++ K R+++ +
Sbjct: 1794 VKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAV--KGLRKHERKV 1851
Query: 442 AELTHANNRVDQN----EAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEK 497
ELT+ +N + V KL+ +V+ K+ + E++ + +L++ R++Q L+E +
Sbjct: 1852 KELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAE 1911
Query: 498 ERNENLETELRHLQ 511
ER + E+++ L+
Sbjct: 1912 ERADIAESQVNKLR 1925
Score = 64.7 bits (156), Expect = 2e-10
Identities = 103/480 (21%), Positives = 206/480 (42%), Gaps = 84/480 (17%)
Query: 77 ELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAER-NSAREEGRQLRIKLEMAMKELS 135
++E K R A+ +K R + T + +R + +S E G Q+ L+ ++L
Sbjct: 1164 QIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQID-NLQRVKQKLE 1222
Query: 136 TLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIREYLVKRQFST 195
K+K + + + L +N+ K G +E+ C + QLS + T
Sbjct: 1223 --KEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALED-QLS--------------EIKT 1265
Query: 196 KEDTNNKEQGVVIDSLKL--------SEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAIN 247
KE+ EQ +I+ L S E LD D + S G+ +++ +
Sbjct: 1266 KEE----EQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLS-RGKQAFTQQIEELK 1320
Query: 248 LPLENEVTEISALQVHL-------DEFQKILWKEREMRTALEKEIERLESALSLWKWKY- 299
LE E+ SAL L D ++ +E+E + L++ + + S ++ W+ KY
Sbjct: 1321 RQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYE 1380
Query: 300 -------EELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAEL 352
EEL+E+K K + L + ++ ++ K++ + +L ++
Sbjct: 1381 TDAIQRTEELEEAKKKLAQR----LQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDV 1436
Query: 353 ERLQA-------------ENTSEW-DKREILEREKQGLERENRRLKIQVKEM----EELL 394
ER A + +EW K E E + ++E+R L ++ ++ EE L
Sbjct: 1437 ERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESL 1496
Query: 395 DKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAE----LTHANNR 450
D+ L +++ ++S DL E+ E H K+ +Q + +E L A
Sbjct: 1497 DQLETLKRENKNLQQEIS--DLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEAS 1554
Query: 451 VDQNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRK--------LQRSLDEE-KERNE 501
++ E ++ +++L + ++K +++K E D+ ++Q+++ +Q +LD E + RN+
Sbjct: 1555 LEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRND 1614
Score = 53.1 bits (126), Expect = 6e-07
Identities = 84/409 (20%), Positives = 171/409 (41%), Gaps = 48/409 (11%)
Query: 118 EEGRQLRIKLEMAMKELS-TLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHT--DQF 174
E+ +++R+ LE A ++L LK Q E + + + LK F + D+
Sbjct: 1043 EQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQ 1102
Query: 175 QLSSQMHESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVD--LFNNGGS 232
L Q+ + I+E ++ + E+ E+ + K ++ L+ + L GG+
Sbjct: 1103 ALGMQLQKKIKE--LQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGA 1160
Query: 233 GNGETKTGLRLKAI---------NLPLENEVTEISALQVHLDEFQKILWKEREMRTALEK 283
+ + + + +A L++E T + + H D ++ E L++
Sbjct: 1161 TSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAEL----GEQIDNLQR 1216
Query: 284 EIERLESALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDR 343
++LE S K + ++L N++ G + L + E + + R
Sbjct: 1217 VKQKLEKEKSEMKMEIDDLAS----NMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQR 1272
Query: 344 VICELRAELERLQAEN---TSEWDKREIL----EREKQGLERENRRLKIQVKEMEELLDK 396
+I +L A+ RLQ E+ + + D+++ L R KQ ++ LK +++EE +
Sbjct: 1273 LINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELK---RQLEEEIKA 1329
Query: 397 KNRLSANSQSP--DFKMSQIDLQEKNQELLNLQHAYYKLNRQY-QANIAELTHANNRVDQ 453
K+ L+ QS D + + +E+ + LQ A K N + Q T A R ++
Sbjct: 1330 KSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEE 1389
Query: 454 NEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNEN 502
+EE K+ L Q+ + ++ + + SL++ K+R +N
Sbjct: 1390 -----------LEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQN 1427
Score = 50.4 bits (119), Expect = 4e-06
Identities = 92/484 (19%), Positives = 198/484 (40%), Gaps = 76/484 (15%)
Query: 68 DICEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWS-------KVRAERNSAREEG 120
D C EL+ +++++++ A++EK + N E+ + K+ E+ + +E
Sbjct: 949 DECSELK-KDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAH 1007
Query: 121 RQLRIKLEMAMKELSTLKK-KQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQ 179
+Q L+ +++TL K K L Q + LE ++ Q+ K+ +E +
Sbjct: 1008 QQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERA------------ 1055
Query: 180 MHESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKT 239
+ L Q ST + N+K+Q L E++K + +G E +
Sbjct: 1056 -KRKLEGDLKLAQESTMDIENDKQQ--------LDEKLKKK----EFEMSGLQSKIEDE- 1101
Query: 240 GLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKE-----------IERL 288
+A+ + L+ ++ E LQ ++E ++ + ER R EK+ ERL
Sbjct: 1102 ----QALGMQLQKKIKE---LQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERL 1154
Query: 289 ESALSLWKWKYE--------------ELKESKPKNVKEFDILLGQHNDEMQELSGNIKEE 334
E A + E +L+E+ ++ L +H D + EL I
Sbjct: 1155 EEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNL 1214
Query: 335 SKSQNSKDRVICELRAELERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEELL 394
+ + ++ E++ E++ L + + + LE+ + LE + +K + +E + L+
Sbjct: 1215 QRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLI 1274
Query: 395 DKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHA-------YYKLNRQYQANIAELTHA 447
+ A Q+ + S+ L EK+ + L +L RQ + I +
Sbjct: 1275 NDLTAQRARLQTESGEYSR-QLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSAL 1333
Query: 448 NNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEK-ERNENLETE 506
+ + + + LR + EE ++ + + + + +++ + + + + +R E LE
Sbjct: 1334 AHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEA 1393
Query: 507 LRHL 510
+ L
Sbjct: 1394 KKKL 1397
Score = 42.7 bits (99), Expect = 8e-04
Identities = 64/308 (20%), Positives = 137/308 (44%), Gaps = 31/308 (10%)
Query: 204 QGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLENEVTEISALQVH 263
+G IDS K SE++ ++D ++ G TK + + L E +++ L
Sbjct: 736 EGQFIDSKKASEKLLGSID----IDHTQYKFGHTKVFFKAGLLGLLEEMRDEKLAQLITR 791
Query: 264 LDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELKESKPKNVKEFDILLGQHNDE 323
+ + + R +K +ER ES + NV+ F + +
Sbjct: 792 T----QAMCRGFLARVEYQKMVERRESIFCI------------QYNVRAF---MNVKHWP 832
Query: 324 MQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWDKREILEREKQGLERENRRL 383
+L IK KS + ++ + ++ E E+ + E KR+ LE + L +E L
Sbjct: 833 WMKLYFKIKPLLKSAET-EKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDL 891
Query: 384 KIQVK-EMEELLDKKNR---LSANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQA 439
++QV+ E + L D + R L + K+ ++ + +++E +N + K R+ +
Sbjct: 892 QLQVQAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKK--RKLED 949
Query: 440 NIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKER 499
+EL + ++ A+V+K + E + L ++ LD+++ ++ K +++L E ++
Sbjct: 950 ECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQ 1009
Query: 500 N-ENLETE 506
++L+ E
Sbjct: 1010 TLDDLQAE 1017
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 77.0 bits (188), Expect = 4e-14
Identities = 103/494 (20%), Positives = 214/494 (43%), Gaps = 62/494 (12%)
Query: 77 ELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKL-------EM 129
++E A AA ++K R + A W++K+ + ++E S+++E R L +L E
Sbjct: 1433 DVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEE 1492
Query: 130 AMKELSTLKKKQS----------------------LPPQKEALEANVTQDLKLPGFVEE- 166
+++ L T K++ L ++ LE + L+L +EE
Sbjct: 1493 SLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEV---EKLELQSALEEA 1549
Query: 167 --SCEHTDQFQLSSQMHESIREYLVKRQFSTKEDTNN---KEQGVVIDSLKLSEEMKPNL 221
S EH + L +Q+ + + ++R+ + K++ + V+DSL+ S + +
Sbjct: 1550 EASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRS 1609
Query: 222 DGVDLFNNGGSGNGETKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTAL 281
L + ++L N ++ +LQ L + Q L L
Sbjct: 1610 RNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDL 1669
Query: 282 EKEIERLESALSLWKWKYEELK---ESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQ 338
++ I +E +L + + EEL+ E ++ K + L + ++ +Q L +
Sbjct: 1670 KENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQK 1729
Query: 339 NSKDRVICELRAELERLQAE--NTSEWDKREI---------LEREKQG---LERENRRLK 384
+ + +L++E+E E N E K+ I L++E+ LER + ++
Sbjct: 1730 KKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNME 1789
Query: 385 IQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAY---YKLNRQYQANI 441
+K+++ LD+ +++ + + ++E EL Q K R+ + I
Sbjct: 1790 QTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRI 1849
Query: 442 AELTHANNRVDQN----EAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEK 497
ELT+ +N + V KL+L+V+ K+ + E++ + +L++ RK+Q LDE +
Sbjct: 1850 KELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAE 1909
Query: 498 ERNENLETELRHLQ 511
ER + E+++ L+
Sbjct: 1910 ERADIAESQVNKLR 1923
Score = 68.6 bits (166), Expect = 1e-11
Identities = 109/465 (23%), Positives = 206/465 (44%), Gaps = 56/465 (12%)
Query: 54 AHNFCAHSYNTNKWDICEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAER 113
A N AH+ + + D C+ LR + EE +A+A ++++ + + A WR K+ +R
Sbjct: 1327 AKNALAHALQSARHD-CDLLREQYEEETEAKA-ELQRVLSKANSEVAQWRTKYETDAIQR 1384
Query: 114 NSAREEGRQ-LRIKLEMAMKELSTLKKK-QSLPPQKEALEANVTQDLKLPGFVEESCEHT 171
EE ++ L +L+ A + + + K SL K L+ N +DL + VE S
Sbjct: 1385 TEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQ-NEIEDLMVD--VERSNAAA 1441
Query: 172 DQFQLSSQMHESI-REYLVKRQFSTKE-DTNNKE-QGVVIDSLKLSEEMKPNLDGVDLFN 228
+ + I E+ K + S E +++ KE + + + KL + +L+ ++ F
Sbjct: 1442 AALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFK 1501
Query: 229 NGGSGNGETKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERL 288
+N EIS L L E K + + ++R LE E L
Sbjct: 1502 REN-------------------KNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLEL 1542
Query: 289 ESALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQ-ELSGNIKEESKSQNSKDRVICE 347
+SAL + E E + + + Q E++ +L+ +E +++ + RV+
Sbjct: 1543 QSALE----EAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDS 1598
Query: 348 LRAELERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSP 407
L+ L+ AE S + E+L R ++++ + EME L NR++A +Q
Sbjct: 1599 LQTSLD---AETRS---RNEVL--------RVKKKMEGDLNEMEIQLSHANRMAAEAQK- 1643
Query: 408 DFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEE 467
K Q L++ +L + A N + NIA + NN + +AE+++LR VE+
Sbjct: 1644 QVKSLQSLLKDTQIQLDDAVRA----NDDLKENIAIVERRNNLL---QAELEELRAVVEQ 1696
Query: 468 LKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRHLQN 512
++ E EL ++ +++ L + + +E++L LQ+
Sbjct: 1697 TERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQS 1741
Score = 61.2 bits (147), Expect = 2e-09
Identities = 116/505 (22%), Positives = 211/505 (41%), Gaps = 88/505 (17%)
Query: 76 RELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREE--------GRQLRIKL 127
++L+E +AR ++E+ + ++ TA R K K+R++ + EE G +++
Sbjct: 1108 KKLKENQARIEELEEELE--AERTA--RAKVEKLRSDLSRELEEISERLEEAGGATSVQI 1163
Query: 128 EMAMKELSTLKKK----QSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHES 183
EM K + +K + Q EA A + + K V E E D Q Q E
Sbjct: 1164 EMNKKREAEFQKMRRDLEEATLQHEATAAALRK--KHADSVAELGEQIDNLQRVKQKLEK 1221
Query: 184 IREYLVKRQFSTKED--TNNKEQGVV----IDSLKLSEEMKPNLDGVDLFNNGGSGNGET 237
K +F + D T+N EQ + ++ + + E + N V L S N T
Sbjct: 1222 -----EKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFT 1276
Query: 238 KTGLRLKAINLPLENEVTEISALQVHL-----------DEFQKILWKEREMRTALEKEIE 286
+L+ N L ++ E AL L ++ ++ L +E + + AL ++
Sbjct: 1277 TQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQ 1336
Query: 287 RLESALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQEL-----SGNIKEESKSQNSK 341
L + +YEE E+K E +L + N E+ + + I+ + + +K
Sbjct: 1337 SARHDCDLLREQYEEETEAKA----ELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAK 1392
Query: 342 DRVICELRAELERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEEL---LDKKN 398
++ L+ E ++A N K LE+ K L+ E L + V+ LDKK
Sbjct: 1393 KKLAQRLQDAEEAVEAVNA----KCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQ 1448
Query: 399 R-----LSANSQSPDFKMSQIDLQEK-----NQELLNLQHAYYKL----------NRQYQ 438
R L+ Q + S+++ +K + EL L++AY + N+ Q
Sbjct: 1449 RNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQ 1508
Query: 439 ANIAELTHANNRVDQNEAEVKKLRLRVE----ELKQGLNQKEDELDDSLNQIRKLQRSLD 494
I++LT +N E++K+R ++E EL+ L + E L+ +I + Q +
Sbjct: 1509 EEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFN 1568
Query: 495 EEK--------ERNENLETELRHLQ 511
+ K E++E +E R+ Q
Sbjct: 1569 QIKAEIERKLAEKDEEMEQAKRNHQ 1593
Score = 57.0 bits (136), Expect = 4e-08
Identities = 51/235 (21%), Positives = 97/235 (41%), Gaps = 30/235 (12%)
Query: 273 KEREMRTALEKEIERLESALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIK 332
K +EM LE E E + + L+ K K E+ K++ + ++ L + E +K
Sbjct: 920 KVKEMNERLEDE-EEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVK 978
Query: 333 EESKSQNSKDRVICELRAELERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEE 392
++ D +I +L E + LQ + D ++ E + L + +L+ QV ++E
Sbjct: 979 NLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEG 1038
Query: 393 LLDKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVD 452
L+++ ++ ++L+ A KL + + N
Sbjct: 1039 SLEQEKKVR----------------------MDLERAKRKLEGDLKLTQESIMDLENDKL 1076
Query: 453 QNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETEL 507
Q E ++KK + NQ+ +++D +LQ+ L E + R E LE EL
Sbjct: 1077 QLEEKLKKKEFDI-------NQQNSKIEDEQVLALQLQKKLKENQARIEELEEEL 1124
Score = 54.3 bits (129), Expect = 3e-07
Identities = 102/467 (21%), Positives = 198/467 (42%), Gaps = 75/467 (16%)
Query: 74 RLRE-LEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAER---NSAREEGRQL---RIK 126
R++E LE+ +AR ++E+ M + +V+AE+ N A E QL +I+
Sbjct: 860 RIKETLEKSEARRKELEEKM---VSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQ 916
Query: 127 LEMAMKELSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIRE 186
LE +KE++ + L ++E + KL E + D +L+ E
Sbjct: 917 LEAKVKEMN-----ERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVE---- 967
Query: 187 YLVKRQFSTKEDTNN-KEQGVVIDSL--KLSEEMKPNLDGVDLFNNGGSGNGETKTGLRL 243
K + +T+ N E+ +D + KL++E K + + + L++
Sbjct: 968 ---KEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEA----------HQQALDDLQV 1014
Query: 244 KAINLPLENEVTEISALQVHL----DEFQKILWKEREMRTALEKEIERLESALSLWKWKY 299
+ E++V +S +V L D+ + L +E+++R LE+ +LE L L +
Sbjct: 1015 E------EDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESI 1068
Query: 300 EELKESKPK-----NVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELER 354
+L+ K + KEFDI + + I++E + + E +A +E
Sbjct: 1069 MDLENDKLQLEEKLKKKEFDI---------NQQNSKIEDEQVLALQLQKKLKENQARIEE 1119
Query: 355 LQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQI 414
L+ E +E R +E+ + L RE + +++E + ++ ++ +F+ +
Sbjct: 1120 LEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREA-EFQKMRR 1178
Query: 415 DLQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQN-EAEVKKLRLRVEEL----- 468
DL+E + A K + A + E RV Q E E + +L ++++
Sbjct: 1179 DLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNME 1238
Query: 469 -----KQGLNQKEDELDDSLNQIR----KLQRSLDEEKERNENLETE 506
K L + L+D N+ R + QRSL++ + L+TE
Sbjct: 1239 QIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTE 1285
Score = 42.0 bits (97), Expect = 0.001
Identities = 67/307 (21%), Positives = 127/307 (41%), Gaps = 53/307 (17%)
Query: 204 QGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLENEVTEISALQVH 263
+G IDS K +E++ +LD ++ G TK + + L E +S +
Sbjct: 734 EGQFIDSRKGTEKLLSSLD----IDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIITR 789
Query: 264 LDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELKESKPKNVKEFDILLGQHNDE 323
+ + + MR +K +ER ++ L + +W N++ F +G N
Sbjct: 790 MQAQAR----GQLMRIEFKKIVERRDALLVI-QW-----------NIRAF---MGVKNWP 830
Query: 324 MQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWDKREILEREKQGLERENRRL 383
+L IK KS AE E+ A E+ R K+ LE+ R
Sbjct: 831 WMKLYFKIKPLLKS------------AETEKEMATMKEEFG------RIKETLEKSEARR 872
Query: 384 KIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAE 443
K ++M LL +KN L Q+ ++ D +E+ +L+ K Q +A + E
Sbjct: 873 KELEEKMVSLLQEKNDLQLQVQAEQDNLN--DAEERCDQLI-------KNKIQLEAKVKE 923
Query: 444 LTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENL 503
+ N R++ E +L + +L+ ++ + ++DD + K+++ + + +NL
Sbjct: 924 M---NERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNL 980
Query: 504 ETELRHL 510
E+ L
Sbjct: 981 TEEMAGL 987
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 76.3 bits (186), Expect = 6e-14
Identities = 112/505 (22%), Positives = 219/505 (43%), Gaps = 80/505 (15%)
Query: 75 LRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKL------- 127
+R+LE A ++K R + A W++K + +AE +A++E R L +L
Sbjct: 1433 MRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAY 1492
Query: 128 EMAMKELSTLKK-------------KQSLPPQKEALEANVTQ--------DLKLP-GFVE 165
E + +L TL++ +Q K EA T+ DL++ VE
Sbjct: 1493 EEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVE 1552
Query: 166 ESCEHTD------QFQLSSQMHESIREYLVKRQFSTKEDTNNKEQGVVI----------- 208
S EH + Q +LS E R+ + K + + N++ +
Sbjct: 1553 GSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSR 1612
Query: 209 -DSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLENEVTEI-SALQVHLDE 266
D+L+L ++M+ +L+ +++ G S +T L+ + L++ + AL+ + D
Sbjct: 1613 NDALRLKKKMEGDLNEMEI-QLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDL 1671
Query: 267 FQKILWKEREMRTALEKEIERLESALSLWKWKYEELKESKPKNVKEFDILLGQHNDEM-- 324
+++ ER LE E+E ++ AL + + L E + + + LL N +
Sbjct: 1672 KEQLAIVERRNGLLLE-ELEEMKVALEQTE-RTRRLSEQELLDASDRVQLLHSQNTSLIN 1729
Query: 325 -------------QELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWDKREILER 371
E+ +I+E ++ + I + E L+ E D LER
Sbjct: 1730 TKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQ----DTSAHLER 1785
Query: 372 EKQGLERENRRLKIQVKEMEELLDK--KNRLSANSQSPDFKMSQIDLQEK-NQELLNLQH 428
K+ LE+ + L+ ++ E E+L K K ++ +++D+++K E L H
Sbjct: 1786 MKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAH 1845
Query: 429 AYYKLNRQ--YQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQI 486
Y + ++ YQ AE H N + + + V KL+ +V+ K+ + E++ + L++
Sbjct: 1846 KYERKVKEMTYQ---AEEDHKN--ILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRC 1900
Query: 487 RKLQRSLDEEKERNENLETELRHLQ 511
R++Q L+E ER + E+++ L+
Sbjct: 1901 RRVQHELEEAAERADIAESQVNKLR 1925
Score = 60.5 bits (145), Expect = 4e-09
Identities = 88/456 (19%), Positives = 189/456 (41%), Gaps = 45/456 (9%)
Query: 77 ELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAER-NSAREEGRQLRIKLEMAMKELS 135
++E K R A+ +K R + T + +R ++ +S E G Q+ L+ ++L
Sbjct: 1164 QIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQID-NLQRVKQKLE 1222
Query: 136 TLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHT-DQFQLSSQMHESIREYLVKRQFS 194
K+K L + + + +N+ K +E +C DQF E +Q
Sbjct: 1223 --KEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDE--------QQTQ 1272
Query: 195 TKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLENEV 254
D N ++ + + +LS ++ + + +L+ + +E E
Sbjct: 1273 LIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQ-----QLEELKRQMEEET 1327
Query: 255 TEISALQVHL-------DEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELKESKP 307
+A+ L D ++ +E+E + L++ + + S ++ W+ KYE +
Sbjct: 1328 KAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRT 1387
Query: 308 KNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWDKRE 367
+ ++E L Q +QE N + + S ++ L+ E+E L +
Sbjct: 1388 EELEEAKKKLAQR---LQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACA 1444
Query: 368 ILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQ 427
L+++++ ++ K ++ E + L+ + S + + FKM + +E+++
Sbjct: 1445 TLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKM-----RNAYEEVVDQL 1499
Query: 428 HAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSL---- 483
+ N+ Q I++LT +N E +K + VE+ K L +E++ SL
Sbjct: 1500 ETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEE 1559
Query: 484 NQIRKLQRSLDEEK--------ERNENLETELRHLQ 511
++I ++Q L + K E++E +E R+ Q
Sbjct: 1560 SKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQ 1595
Score = 59.3 bits (142), Expect = 8e-09
Identities = 96/487 (19%), Positives = 197/487 (40%), Gaps = 53/487 (10%)
Query: 65 NKWDICEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKW-------SKVRAERNSAR 117
N D C L+ R++++++ ++EK + N E+ SK+ E+ S +
Sbjct: 946 NLEDKCSSLK-RDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQ 1004
Query: 118 EEGRQLRIKLEMAMKELSTLKK-KQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQL 176
E +Q L++ +++ L K L Q + LE ++ Q+ KL +E + +
Sbjct: 1005 EAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLK 1064
Query: 177 SSQMH--------ESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFN 228
SQ + I E L K++F + K + SL+ +++K ++
Sbjct: 1065 MSQESIMDLENDKQQIEEKLKKKEFELSQ-LQAKIDDEQVHSLQFQKKIKELQARIEELE 1123
Query: 229 NGGSGNGETKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERL 288
E + LR K I + E+ + L+E + EM E E +++
Sbjct: 1124 E----EIEAEHTLRAK-IEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKM 1178
Query: 289 ESALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQ------------------ELSGN 330
L ++E + K + LG+ D +Q +++ N
Sbjct: 1179 RRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASN 1238
Query: 331 IKEESKSQNSKDRVICELRAELERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEM 390
I+ SKS+++ +R + + ++A++ + L +K L+ +N L +V+E
Sbjct: 1239 IEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEK 1298
Query: 391 EELLDK--KNRLSANSQSPDFK-MSQIDLQEKN---QELLNLQHAYYKLNRQYQANIAEL 444
E L+ + K++ + Q + K + + + KN L + +H L QY+
Sbjct: 1299 ESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAK 1358
Query: 445 THANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLE 504
+ + +EV + R + E Q+ +EL+++ +KL + L E +E E
Sbjct: 1359 AELQRALSKANSEVAQWRTKYE---TDAIQRTEELEEAK---KKLAQRLQEAEENTETAN 1412
Query: 505 TELRHLQ 511
++ L+
Sbjct: 1413 SKCASLE 1419
Score = 43.5 bits (101), Expect = 5e-04
Identities = 52/260 (20%), Positives = 100/260 (38%), Gaps = 35/260 (13%)
Query: 277 MRTALEKEIERLESALSL------------WKWKYEELKESKPKNVKEFDILLGQHNDEM 324
MR +K +ER +S + W W K E + + ++
Sbjct: 801 MRVEFKKMMERRDSIFCIQYNIRSFMNVKHWPWMNLFFKIKPLLKSAEAEKEMATMKEDF 860
Query: 325 QELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWDKREILEREKQGLERENRRLK 384
+ + + + + L E LQ + SE + E +GL + L+
Sbjct: 861 ERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSKILLE 920
Query: 385 IQVKEMEELLDKK----NRLSANSQSPDFKMSQI--DLQEKNQELLNLQHAYYKLNRQYQ 438
+VKE+ E L+++ + L A ++ + K S + D+ + L ++ + + +
Sbjct: 921 AKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVK 980
Query: 439 ANIAELTHANNRVDQNEAEVKKLR---------LRVEE--------LKQGLNQKEDELDD 481
E+T + + E K L+ L+VEE + L Q+ D+L+
Sbjct: 981 NLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEG 1040
Query: 482 SLNQIRKLQRSLDEEKERNE 501
SL Q +KL+ L+ K + E
Sbjct: 1041 SLEQEKKLRADLERAKRKLE 1060
Score = 40.4 bits (93), Expect = 0.004
Identities = 35/146 (23%), Positives = 68/146 (46%), Gaps = 12/146 (8%)
Query: 366 REILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELLN 425
+E ER K+ L R R K ++M LL +KN L QS + +D +E+ + L+
Sbjct: 857 KEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENL--MDAEERCEGLI- 913
Query: 426 LQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQ 485
K +A + ELT ++ +E+ + +E+ L + D+L+ +L +
Sbjct: 914 ------KSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTK 967
Query: 486 IRKLQRSLDEEKERNENLETELRHLQ 511
+ K + + + + + NL E+ L+
Sbjct: 968 VEKEKHATENKVK---NLSEEMTALE 990
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 74.3 bits (181), Expect = 2e-13
Identities = 98/451 (21%), Positives = 193/451 (42%), Gaps = 40/451 (8%)
Query: 77 ELEEV-KARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAMKELS 135
ELE K A+ME + D N E RA E QL E+ + +
Sbjct: 1501 ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLE---ELEDELQA 1557
Query: 136 TLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIREYLVKRQFST 195
T K L +AL+ +DL+ + + QL Q+HE + T
Sbjct: 1558 TEDAKLRLEVNMQALKGQFERDLQ----ARDEQNEEKRRQLQRQLHE----------YET 1603
Query: 196 KEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLENEVT 255
+ + K++ + + K +++ +L ++L + G + +L+ + +++
Sbjct: 1604 ELEDERKQRALAAAAKK---KLEGDLKDLELQADSAI-KGREEAIKQLRKLQAQMKDFQR 1659
Query: 256 EISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELKESKPKNVKEFDI 315
E+ + DE + + +LE ++ +L+ L+ + ++ K + +E
Sbjct: 1660 ELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELAS 1719
Query: 316 LLGQHN---DEMQELSGNI--------KEESKSQNSKDRVICELRAELERLQAENTSEWD 364
L N DE + L I +E+ + DRV + + E+L E +E
Sbjct: 1720 SLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR-KATQQAEQLSNELATERS 1778
Query: 365 KREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELL 424
+ E +Q LER+N+ L+ ++ EME + K++ + + + K++Q++ ++ QE
Sbjct: 1779 TAQKNESARQQLERQNKELRSKLHEMEGAV--KSKFKSTIAALEAKIAQLE-EQVEQEAR 1835
Query: 425 NLQHAYYKL---NRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDD 481
Q A L +++ + + ++ +Q + + +K RV++LK+ L + E+E
Sbjct: 1836 EKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQR 1895
Query: 482 SLNQIRKLQRSLDEEKERNENLETELRHLQN 512
RKLQR LDE E NE + E+ L++
Sbjct: 1896 INANRRKLQRELDEATESNEAMGREVNALKS 1926
Score = 70.5 bits (171), Expect = 4e-12
Identities = 103/466 (22%), Positives = 195/466 (41%), Gaps = 77/466 (16%)
Query: 76 RELEEVKARAAQMEKTMRWWSDCTANWRE---KWSKVRAERNSARE----------EGRQ 122
R+ EE++A+ +++KT +E K S++ E+N +E E +
Sbjct: 849 RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE 908
Query: 123 LRIKLEMAMKEL--------STLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQF 174
+R++L +EL + L++++ Q +A + Q + +EE E +
Sbjct: 909 MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQML---DLEEQLEEEEAA 965
Query: 175 QLSSQMHESIREYLVKR---QFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGV-DLFNNG 230
+ Q+ + E +K+ + +D NNK LS+E K + + DL N
Sbjct: 966 RQKLQLEKVTAEAKIKKLEDEILVMDDQNNK----------LSKERKLLEERISDLTTNL 1015
Query: 231 GSGNGETKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLES 290
+ K +LK + IS L+V L KE + R +E+E+L+
Sbjct: 1016 AEEEEKAKNLTKLK------NKHESMISELEVRLK-------KEEKSR----QELEKLKR 1058
Query: 291 ALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRA 350
L + E + E + L + +E+Q + +E +N+ + I EL
Sbjct: 1059 KLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEG 1118
Query: 351 ELERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFK 410
+ LQ + SE R E++K+ L E LK E+E+ LD +A Q K
Sbjct: 1119 HISDLQEDLDSERAARNKAEKQKRDLGEELEALK---TELEDTLDS----TATQQELRAK 1171
Query: 411 MSQIDLQEKNQELLNLQHAYYKLNRQYQANIAEL----THANNRVDQNEAEVKKLRLRVE 466
+ QE+ L+ A + R ++A + E+ A + + + K+ + ++
Sbjct: 1172 --------REQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD 1223
Query: 467 ELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRHLQN 512
+ KQ L E E D ++R L ++ E + + + LE +++ LQ+
Sbjct: 1224 KNKQTL---EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQS 1266
Score = 57.8 bits (138), Expect = 2e-08
Identities = 128/564 (22%), Positives = 226/564 (40%), Gaps = 132/564 (23%)
Query: 72 ELRLREL-EEVKARAAQMEKTMRWWSDCTANWREKWSKVRAE----RNSAREEGR----- 121
E + R+L EE++A ++E T+ D TA +E +K E + + EE R
Sbjct: 1138 EKQKRDLGEELEALKTELEDTL----DSTATQQELRAKREQEVTVLKKALDEETRSHEAQ 1193
Query: 122 --QLRIKLEMAMKELSTL-----KKKQSLPPQKEALE---ANVTQDLKLPGFVEESCEHT 171
++R K A++EL+ + K +L K+ LE A++ +L++ G ++ EH
Sbjct: 1194 VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHK 1253
Query: 172 DQFQLSSQMHE-------------SIREYLVKRQFSTKEDTN--NKEQGVVIDSLKLSEE 216
+ +L +Q+ E + + + K Q + T N+ +G I K
Sbjct: 1254 KK-KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1312
Query: 217 MKPNL-DGVDLFNNGGSGNGETKTGLR-LKAINLPLENEVTE-----------ISALQVH 263
+ L D +L T LR L+ L++++ E IS L +
Sbjct: 1313 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1372
Query: 264 LDEFQKILWKEREMRTALE-------KEIERLESALSLWKWKYEELKESKPKNVKEFDIL 316
L + +K L ALE KEIE L Y++L+++K + +E D L
Sbjct: 1373 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 1432
Query: 317 LGQHNDEMQELSGNIKEE--------------SKSQNSKDRVICELR-----------AE 351
+ +++ Q +S K++ SK + +DR E R A
Sbjct: 1433 VVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL 1492
Query: 352 LERLQA----ENTSEWDKREI----------------LEREKQGLERENRRLKIQVKEME 391
E L+A E T++ K E+ LE+ K+ LE + +K Q++E+E
Sbjct: 1493 EEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELE 1552
Query: 392 ELL----DKKNRLSANSQS------PDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANI 441
+ L D K RL N Q+ D + +EK ++L H Y +
Sbjct: 1553 DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR 1612
Query: 442 AELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLD------- 494
A A ++ E ++K L L+ + +G + +L Q++ QR L+
Sbjct: 1613 ALAAAAKKKL---EGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD 1669
Query: 495 -------EEKERNENLETELRHLQ 511
E +++ ++LE +L LQ
Sbjct: 1670 EIFATAKENEKKAKSLEADLMQLQ 1693
Score = 55.1 bits (131), Expect = 2e-07
Identities = 102/464 (21%), Positives = 188/464 (40%), Gaps = 77/464 (16%)
Query: 72 ELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAM 131
EL +R +E K+R ++EK R +++ E+ + ++A+ +K+++A
Sbjct: 1038 ELEVRLKKEEKSRQ-ELEKLKRKLEGDASDFHEQIADLQAQI---------AELKMQLA- 1086
Query: 132 KELSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIREYLVKR 191
KK++ L L+ + Q + E H Q + R
Sbjct: 1087 ------KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARN----- 1135
Query: 192 QFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLE 251
K + ++ G +++LK E++ LD T+ LR K E
Sbjct: 1136 ----KAEKQKRDLGEELEALKT--ELEDTLDST-----------ATQQELRAKR-----E 1173
Query: 252 NEVTEISALQVHLDEFQKILWKE-REMRTALEKEIERLESALSLWKWKYEELKESKPKNV 310
EVT L+ LDE + + +EMR + +E L L +K L ++K
Sbjct: 1174 QEVT---VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE 1230
Query: 311 KEFDIL------LGQHNDEMQ----ELSGNIKEESKSQNSKDRVICELRAELERLQAENT 360
KE L LGQ E++ +L ++E + +R EL ++ +LQ E
Sbjct: 1231 KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVE 1290
Query: 361 SEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQID----- 415
S E + L ++ L Q+++ +ELL ++ R N + K+ Q++
Sbjct: 1291 SVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVST---KLRQLEEERNS 1347
Query: 416 ----LQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQG 471
L E+ + NL+ LN Q + +L + V+ E K+ + +E L Q
Sbjct: 1348 LQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQ 1407
Query: 472 LNQKE---DELDDSLNQIRK----LQRSLDEEKERNENLETELR 508
+K D+L+ + N++++ L LD +++ NLE + R
Sbjct: 1408 YEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQR 1451
Score = 38.5 bits (88), Expect = 0.015
Identities = 63/335 (18%), Positives = 138/335 (41%), Gaps = 67/335 (20%)
Query: 76 RELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAMKEL- 134
RELE+ +A ++ T + + +++ + +A +Q ++ E +EL
Sbjct: 1659 RELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1718
Query: 135 STLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEH--------TDQFQLSSQMHESIRE 186
S+L + +L +K LEA + Q +EE E +D+ + ++Q E +
Sbjct: 1719 SSLSGRNALQDEKRRLEARIAQ-------LEEELEEEQGNMEAMSDRVRKATQQAEQL-- 1769
Query: 187 YLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAI 246
+ +T+ T K + + ++E++ L ++ G K+ +
Sbjct: 1770 ---SNELATERSTAQKNESARQQLERQNKELRSKLHEME---------GAVKSKFK---- 1813
Query: 247 NLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELKESK 306
+ I+AL+ + + ++ +E+E ++A K K ++LKE
Sbjct: 1814 --------STIAALEAKIAQLEE----------QVEQEAREKQAATKSLKQKDKKLKE-- 1853
Query: 307 PKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWDKR 366
+L Q DE ++++ KE+++ N++ + +L+ +LE + E+ R
Sbjct: 1854 ---------ILLQVEDE-RKMAEQYKEQAEKGNAR---VKQLKRQLEEAEEESQRINANR 1900
Query: 367 EILEREKQGLERENRRLKIQVKEMEELLDKKNRLS 401
L+RE N + +V ++ L + N S
Sbjct: 1901 RKLQRELDEATESNEAMGREVNALKSKLRRGNETS 1935
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 74.3 bits (181), Expect = 2e-13
Identities = 98/451 (21%), Positives = 193/451 (42%), Gaps = 40/451 (8%)
Query: 77 ELEEV-KARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAMKELS 135
ELE K A+ME + D N E RA E QL E+ + +
Sbjct: 1508 ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLE---ELEDELQA 1564
Query: 136 TLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIREYLVKRQFST 195
T K L +AL+ +DL+ + + QL Q+HE + T
Sbjct: 1565 TEDAKLRLEVNMQALKGQFERDLQ----ARDEQNEEKRRQLQRQLHE----------YET 1610
Query: 196 KEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLENEVT 255
+ + K++ + + K +++ +L ++L + G + +L+ + +++
Sbjct: 1611 ELEDERKQRALAAAAKK---KLEGDLKDLELQADSAI-KGREEAIKQLRKLQAQMKDFQR 1666
Query: 256 EISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELKESKPKNVKEFDI 315
E+ + DE + + +LE ++ +L+ L+ + ++ K + +E
Sbjct: 1667 ELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELAS 1726
Query: 316 LLGQHN---DEMQELSGNI--------KEESKSQNSKDRVICELRAELERLQAENTSEWD 364
L N DE + L I +E+ + DRV + + E+L E +E
Sbjct: 1727 SLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR-KATQQAEQLSNELATERS 1785
Query: 365 KREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELL 424
+ E +Q LER+N+ L+ ++ EME + K++ + + + K++Q++ ++ QE
Sbjct: 1786 TAQKNESARQQLERQNKELRSKLHEMEGAV--KSKFKSTIAALEAKIAQLE-EQVEQEAR 1842
Query: 425 NLQHAYYKL---NRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDD 481
Q A L +++ + + ++ +Q + + +K RV++LK+ L + E+E
Sbjct: 1843 EKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQR 1902
Query: 482 SLNQIRKLQRSLDEEKERNENLETELRHLQN 512
RKLQR LDE E NE + E+ L++
Sbjct: 1903 INANRRKLQRELDEATESNEAMGREVNALKS 1933
Score = 70.5 bits (171), Expect = 4e-12
Identities = 103/466 (22%), Positives = 195/466 (41%), Gaps = 77/466 (16%)
Query: 76 RELEEVKARAAQMEKTMRWWSDCTANWRE---KWSKVRAERNSARE----------EGRQ 122
R+ EE++A+ +++KT +E K S++ E+N +E E +
Sbjct: 856 RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE 915
Query: 123 LRIKLEMAMKEL--------STLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQF 174
+R++L +EL + L++++ Q +A + Q + +EE E +
Sbjct: 916 MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQML---DLEEQLEEEEAA 972
Query: 175 QLSSQMHESIREYLVKR---QFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGV-DLFNNG 230
+ Q+ + E +K+ + +D NNK LS+E K + + DL N
Sbjct: 973 RQKLQLEKVTAEAKIKKLEDEILVMDDQNNK----------LSKERKLLEERISDLTTNL 1022
Query: 231 GSGNGETKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLES 290
+ K +LK + IS L+V L KE + R +E+E+L+
Sbjct: 1023 AEEEEKAKNLTKLK------NKHESMISELEVRLK-------KEEKSR----QELEKLKR 1065
Query: 291 ALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRA 350
L + E + E + L + +E+Q + +E +N+ + I EL
Sbjct: 1066 KLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEG 1125
Query: 351 ELERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFK 410
+ LQ + SE R E++K+ L E LK E+E+ LD +A Q K
Sbjct: 1126 HISDLQEDLDSERAARNKAEKQKRDLGEELEALK---TELEDTLDS----TATQQELRAK 1178
Query: 411 MSQIDLQEKNQELLNLQHAYYKLNRQYQANIAEL----THANNRVDQNEAEVKKLRLRVE 466
+ QE+ L+ A + R ++A + E+ A + + + K+ + ++
Sbjct: 1179 --------REQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD 1230
Query: 467 ELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRHLQN 512
+ KQ L E E D ++R L ++ E + + + LE +++ LQ+
Sbjct: 1231 KNKQTL---EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQS 1273
Score = 57.8 bits (138), Expect = 2e-08
Identities = 128/564 (22%), Positives = 226/564 (40%), Gaps = 132/564 (23%)
Query: 72 ELRLREL-EEVKARAAQMEKTMRWWSDCTANWREKWSKVRAE----RNSAREEGR----- 121
E + R+L EE++A ++E T+ D TA +E +K E + + EE R
Sbjct: 1145 EKQKRDLGEELEALKTELEDTL----DSTATQQELRAKREQEVTVLKKALDEETRSHEAQ 1200
Query: 122 --QLRIKLEMAMKELSTL-----KKKQSLPPQKEALE---ANVTQDLKLPGFVEESCEHT 171
++R K A++EL+ + K +L K+ LE A++ +L++ G ++ EH
Sbjct: 1201 VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHK 1260
Query: 172 DQFQLSSQMHE-------------SIREYLVKRQFSTKEDTN--NKEQGVVIDSLKLSEE 216
+ +L +Q+ E + + + K Q + T N+ +G I K
Sbjct: 1261 KK-KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1319
Query: 217 MKPNL-DGVDLFNNGGSGNGETKTGLR-LKAINLPLENEVTE-----------ISALQVH 263
+ L D +L T LR L+ L++++ E IS L +
Sbjct: 1320 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1379
Query: 264 LDEFQKILWKEREMRTALE-------KEIERLESALSLWKWKYEELKESKPKNVKEFDIL 316
L + +K L ALE KEIE L Y++L+++K + +E D L
Sbjct: 1380 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 1439
Query: 317 LGQHNDEMQELSGNIKEE--------------SKSQNSKDRVICELR-----------AE 351
+ +++ Q +S K++ SK + +DR E R A
Sbjct: 1440 VVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL 1499
Query: 352 LERLQA----ENTSEWDKREI----------------LEREKQGLERENRRLKIQVKEME 391
E L+A E T++ K E+ LE+ K+ LE + +K Q++E+E
Sbjct: 1500 EEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELE 1559
Query: 392 ELL----DKKNRLSANSQS------PDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANI 441
+ L D K RL N Q+ D + +EK ++L H Y +
Sbjct: 1560 DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR 1619
Query: 442 AELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLD------- 494
A A ++ E ++K L L+ + +G + +L Q++ QR L+
Sbjct: 1620 ALAAAAKKKL---EGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD 1676
Query: 495 -------EEKERNENLETELRHLQ 511
E +++ ++LE +L LQ
Sbjct: 1677 EIFATAKENEKKAKSLEADLMQLQ 1700
Score = 55.1 bits (131), Expect = 2e-07
Identities = 102/464 (21%), Positives = 188/464 (40%), Gaps = 77/464 (16%)
Query: 72 ELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAM 131
EL +R +E K+R ++EK R +++ E+ + ++A+ +K+++A
Sbjct: 1045 ELEVRLKKEEKSRQ-ELEKLKRKLEGDASDFHEQIADLQAQI---------AELKMQLA- 1093
Query: 132 KELSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIREYLVKR 191
KK++ L L+ + Q + E H Q + R
Sbjct: 1094 ------KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARN----- 1142
Query: 192 QFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLE 251
K + ++ G +++LK E++ LD T+ LR K E
Sbjct: 1143 ----KAEKQKRDLGEELEALKT--ELEDTLDST-----------ATQQELRAKR-----E 1180
Query: 252 NEVTEISALQVHLDEFQKILWKE-REMRTALEKEIERLESALSLWKWKYEELKESKPKNV 310
EVT L+ LDE + + +EMR + +E L L +K L ++K
Sbjct: 1181 QEVT---VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE 1237
Query: 311 KEFDIL------LGQHNDEMQ----ELSGNIKEESKSQNSKDRVICELRAELERLQAENT 360
KE L LGQ E++ +L ++E + +R EL ++ +LQ E
Sbjct: 1238 KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVE 1297
Query: 361 SEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQID----- 415
S E + L ++ L Q+++ +ELL ++ R N + K+ Q++
Sbjct: 1298 SVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVST---KLRQLEEERNS 1354
Query: 416 ----LQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQG 471
L E+ + NL+ LN Q + +L + V+ E K+ + +E L Q
Sbjct: 1355 LQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQ 1414
Query: 472 LNQKE---DELDDSLNQIRK----LQRSLDEEKERNENLETELR 508
+K D+L+ + N++++ L LD +++ NLE + R
Sbjct: 1415 YEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQR 1458
Score = 38.5 bits (88), Expect = 0.015
Identities = 63/335 (18%), Positives = 138/335 (41%), Gaps = 67/335 (20%)
Query: 76 RELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAMKEL- 134
RELE+ +A ++ T + + +++ + +A +Q ++ E +EL
Sbjct: 1666 RELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1725
Query: 135 STLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEH--------TDQFQLSSQMHESIRE 186
S+L + +L +K LEA + Q +EE E +D+ + ++Q E +
Sbjct: 1726 SSLSGRNALQDEKRRLEARIAQ-------LEEELEEEQGNMEAMSDRVRKATQQAEQL-- 1776
Query: 187 YLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAI 246
+ +T+ T K + + ++E++ L ++ G K+ +
Sbjct: 1777 ---SNELATERSTAQKNESARQQLERQNKELRSKLHEME---------GAVKSKFK---- 1820
Query: 247 NLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELKESK 306
+ I+AL+ + + ++ +E+E ++A K K ++LKE
Sbjct: 1821 --------STIAALEAKIAQLEE----------QVEQEAREKQAATKSLKQKDKKLKE-- 1860
Query: 307 PKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWDKR 366
+L Q DE ++++ KE+++ N++ + +L+ +LE + E+ R
Sbjct: 1861 ---------ILLQVEDE-RKMAEQYKEQAEKGNAR---VKQLKRQLEEAEEESQRINANR 1907
Query: 367 EILEREKQGLERENRRLKIQVKEMEELLDKKNRLS 401
L+RE N + +V ++ L + N S
Sbjct: 1908 RKLQRELDEATESNEAMGREVNALKSKLRRGNETS 1942
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 74.3 bits (181), Expect = 2e-13
Identities = 98/451 (21%), Positives = 193/451 (42%), Gaps = 40/451 (8%)
Query: 77 ELEEV-KARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAMKELS 135
ELE K A+ME + D N E RA E QL E+ + +
Sbjct: 1508 ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLE---ELEDELQA 1564
Query: 136 TLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIREYLVKRQFST 195
T K L +AL+ +DL+ + + QL Q+HE + T
Sbjct: 1565 TEDAKLRLEVNMQALKGQFERDLQ----ARDEQNEEKRRQLQRQLHE----------YET 1610
Query: 196 KEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLENEVT 255
+ + K++ + + K +++ +L ++L + G + +L+ + +++
Sbjct: 1611 ELEDERKQRALAAAAKK---KLEGDLKDLELQADSAI-KGREEAIKQLRKLQAQMKDFQR 1666
Query: 256 EISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELKESKPKNVKEFDI 315
E+ + DE + + +LE ++ +L+ L+ + ++ K + +E
Sbjct: 1667 ELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELAS 1726
Query: 316 LLGQHN---DEMQELSGNI--------KEESKSQNSKDRVICELRAELERLQAENTSEWD 364
L N DE + L I +E+ + DRV + + E+L E +E
Sbjct: 1727 SLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR-KATQQAEQLSNELATERS 1785
Query: 365 KREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELL 424
+ E +Q LER+N+ L+ ++ EME + K++ + + + K++Q++ ++ QE
Sbjct: 1786 TAQKNESARQQLERQNKELRSKLHEMEGAV--KSKFKSTIAALEAKIAQLE-EQVEQEAR 1842
Query: 425 NLQHAYYKL---NRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDD 481
Q A L +++ + + ++ +Q + + +K RV++LK+ L + E+E
Sbjct: 1843 EKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQR 1902
Query: 482 SLNQIRKLQRSLDEEKERNENLETELRHLQN 512
RKLQR LDE E NE + E+ L++
Sbjct: 1903 INANRRKLQRELDEATESNEAMGREVNALKS 1933
Score = 70.5 bits (171), Expect = 4e-12
Identities = 103/466 (22%), Positives = 195/466 (41%), Gaps = 77/466 (16%)
Query: 76 RELEEVKARAAQMEKTMRWWSDCTANWRE---KWSKVRAERNSARE----------EGRQ 122
R+ EE++A+ +++KT +E K S++ E+N +E E +
Sbjct: 856 RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE 915
Query: 123 LRIKLEMAMKEL--------STLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQF 174
+R++L +EL + L++++ Q +A + Q + +EE E +
Sbjct: 916 MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQML---DLEEQLEEEEAA 972
Query: 175 QLSSQMHESIREYLVKR---QFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGV-DLFNNG 230
+ Q+ + E +K+ + +D NNK LS+E K + + DL N
Sbjct: 973 RQKLQLEKVTAEAKIKKLEDEILVMDDQNNK----------LSKERKLLEERISDLTTNL 1022
Query: 231 GSGNGETKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLES 290
+ K +LK + IS L+V L KE + R +E+E+L+
Sbjct: 1023 AEEEEKAKNLTKLK------NKHESMISELEVRLK-------KEEKSR----QELEKLKR 1065
Query: 291 ALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRA 350
L + E + E + L + +E+Q + +E +N+ + I EL
Sbjct: 1066 KLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEG 1125
Query: 351 ELERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFK 410
+ LQ + SE R E++K+ L E LK E+E+ LD +A Q K
Sbjct: 1126 HISDLQEDLDSERAARNKAEKQKRDLGEELEALK---TELEDTLDS----TATQQELRAK 1178
Query: 411 MSQIDLQEKNQELLNLQHAYYKLNRQYQANIAEL----THANNRVDQNEAEVKKLRLRVE 466
+ QE+ L+ A + R ++A + E+ A + + + K+ + ++
Sbjct: 1179 --------REQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD 1230
Query: 467 ELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRHLQN 512
+ KQ L E E D ++R L ++ E + + + LE +++ LQ+
Sbjct: 1231 KNKQTL---EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQS 1273
Score = 57.8 bits (138), Expect = 2e-08
Identities = 128/564 (22%), Positives = 226/564 (40%), Gaps = 132/564 (23%)
Query: 72 ELRLREL-EEVKARAAQMEKTMRWWSDCTANWREKWSKVRAE----RNSAREEGR----- 121
E + R+L EE++A ++E T+ D TA +E +K E + + EE R
Sbjct: 1145 EKQKRDLGEELEALKTELEDTL----DSTATQQELRAKREQEVTVLKKALDEETRSHEAQ 1200
Query: 122 --QLRIKLEMAMKELSTL-----KKKQSLPPQKEALE---ANVTQDLKLPGFVEESCEHT 171
++R K A++EL+ + K +L K+ LE A++ +L++ G ++ EH
Sbjct: 1201 VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHK 1260
Query: 172 DQFQLSSQMHE-------------SIREYLVKRQFSTKEDTN--NKEQGVVIDSLKLSEE 216
+ +L +Q+ E + + + K Q + T N+ +G I K
Sbjct: 1261 KK-KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1319
Query: 217 MKPNL-DGVDLFNNGGSGNGETKTGLR-LKAINLPLENEVTE-----------ISALQVH 263
+ L D +L T LR L+ L++++ E IS L +
Sbjct: 1320 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1379
Query: 264 LDEFQKILWKEREMRTALE-------KEIERLESALSLWKWKYEELKESKPKNVKEFDIL 316
L + +K L ALE KEIE L Y++L+++K + +E D L
Sbjct: 1380 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 1439
Query: 317 LGQHNDEMQELSGNIKEE--------------SKSQNSKDRVICELR-----------AE 351
+ +++ Q +S K++ SK + +DR E R A
Sbjct: 1440 VVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL 1499
Query: 352 LERLQA----ENTSEWDKREI----------------LEREKQGLERENRRLKIQVKEME 391
E L+A E T++ K E+ LE+ K+ LE + +K Q++E+E
Sbjct: 1500 EEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELE 1559
Query: 392 ELL----DKKNRLSANSQS------PDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANI 441
+ L D K RL N Q+ D + +EK ++L H Y +
Sbjct: 1560 DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR 1619
Query: 442 AELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLD------- 494
A A ++ E ++K L L+ + +G + +L Q++ QR L+
Sbjct: 1620 ALAAAAKKKL---EGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD 1676
Query: 495 -------EEKERNENLETELRHLQ 511
E +++ ++LE +L LQ
Sbjct: 1677 EIFATAKENEKKAKSLEADLMQLQ 1700
Score = 55.1 bits (131), Expect = 2e-07
Identities = 102/464 (21%), Positives = 188/464 (40%), Gaps = 77/464 (16%)
Query: 72 ELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAM 131
EL +R +E K+R ++EK R +++ E+ + ++A+ +K+++A
Sbjct: 1045 ELEVRLKKEEKSRQ-ELEKLKRKLEGDASDFHEQIADLQAQI---------AELKMQLA- 1093
Query: 132 KELSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIREYLVKR 191
KK++ L L+ + Q + E H Q + R
Sbjct: 1094 ------KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARN----- 1142
Query: 192 QFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLE 251
K + ++ G +++LK E++ LD T+ LR K E
Sbjct: 1143 ----KAEKQKRDLGEELEALKT--ELEDTLDST-----------ATQQELRAKR-----E 1180
Query: 252 NEVTEISALQVHLDEFQKILWKE-REMRTALEKEIERLESALSLWKWKYEELKESKPKNV 310
EVT L+ LDE + + +EMR + +E L L +K L ++K
Sbjct: 1181 QEVT---VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE 1237
Query: 311 KEFDIL------LGQHNDEMQ----ELSGNIKEESKSQNSKDRVICELRAELERLQAENT 360
KE L LGQ E++ +L ++E + +R EL ++ +LQ E
Sbjct: 1238 KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVE 1297
Query: 361 SEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQID----- 415
S E + L ++ L Q+++ +ELL ++ R N + K+ Q++
Sbjct: 1298 SVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVST---KLRQLEEERNS 1354
Query: 416 ----LQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQG 471
L E+ + NL+ LN Q + +L + V+ E K+ + +E L Q
Sbjct: 1355 LQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQ 1414
Query: 472 LNQKE---DELDDSLNQIRK----LQRSLDEEKERNENLETELR 508
+K D+L+ + N++++ L LD +++ NLE + R
Sbjct: 1415 YEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQR 1458
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 74.3 bits (181), Expect = 2e-13
Identities = 98/451 (21%), Positives = 193/451 (42%), Gaps = 40/451 (8%)
Query: 77 ELEEV-KARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAMKELS 135
ELE K A+ME + D N E RA E QL E+ + +
Sbjct: 1501 ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLE---ELEDELQA 1557
Query: 136 TLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIREYLVKRQFST 195
T K L +AL+ +DL+ + + QL Q+HE + T
Sbjct: 1558 TEDAKLRLEVNMQALKGQFERDLQ----ARDEQNEEKRRQLQRQLHE----------YET 1603
Query: 196 KEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLENEVT 255
+ + K++ + + K +++ +L ++L + G + +L+ + +++
Sbjct: 1604 ELEDERKQRALAAAAKK---KLEGDLKDLELQADSAI-KGREEAIKQLRKLQAQMKDFQR 1659
Query: 256 EISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELKESKPKNVKEFDI 315
E+ + DE + + +LE ++ +L+ L+ + ++ K + +E
Sbjct: 1660 ELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELAS 1719
Query: 316 LLGQHN---DEMQELSGNI--------KEESKSQNSKDRVICELRAELERLQAENTSEWD 364
L N DE + L I +E+ + DRV + + E+L E +E
Sbjct: 1720 SLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR-KATQQAEQLSNELATERS 1778
Query: 365 KREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELL 424
+ E +Q LER+N+ L+ ++ EME + K++ + + + K++Q++ ++ QE
Sbjct: 1779 TAQKNESARQQLERQNKELRSKLHEMEGAV--KSKFKSTIAALEAKIAQLE-EQVEQEAR 1835
Query: 425 NLQHAYYKL---NRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDD 481
Q A L +++ + + ++ +Q + + +K RV++LK+ L + E+E
Sbjct: 1836 EKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQR 1895
Query: 482 SLNQIRKLQRSLDEEKERNENLETELRHLQN 512
RKLQR LDE E NE + E+ L++
Sbjct: 1896 INANRRKLQRELDEATESNEAMGREVNALKS 1926
Score = 70.5 bits (171), Expect = 4e-12
Identities = 103/466 (22%), Positives = 195/466 (41%), Gaps = 77/466 (16%)
Query: 76 RELEEVKARAAQMEKTMRWWSDCTANWRE---KWSKVRAERNSARE----------EGRQ 122
R+ EE++A+ +++KT +E K S++ E+N +E E +
Sbjct: 849 RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE 908
Query: 123 LRIKLEMAMKEL--------STLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQF 174
+R++L +EL + L++++ Q +A + Q + +EE E +
Sbjct: 909 MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQML---DLEEQLEEEEAA 965
Query: 175 QLSSQMHESIREYLVKR---QFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGV-DLFNNG 230
+ Q+ + E +K+ + +D NNK LS+E K + + DL N
Sbjct: 966 RQKLQLEKVTAEAKIKKLEDEILVMDDQNNK----------LSKERKLLEERISDLTTNL 1015
Query: 231 GSGNGETKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLES 290
+ K +LK + IS L+V L KE + R +E+E+L+
Sbjct: 1016 AEEEEKAKNLTKLK------NKHESMISELEVRLK-------KEEKSR----QELEKLKR 1058
Query: 291 ALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRA 350
L + E + E + L + +E+Q + +E +N+ + I EL
Sbjct: 1059 KLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEG 1118
Query: 351 ELERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFK 410
+ LQ + SE R E++K+ L E LK E+E+ LD +A Q K
Sbjct: 1119 HISDLQEDLDSERAARNKAEKQKRDLGEELEALK---TELEDTLDS----TATQQELRAK 1171
Query: 411 MSQIDLQEKNQELLNLQHAYYKLNRQYQANIAEL----THANNRVDQNEAEVKKLRLRVE 466
+ QE+ L+ A + R ++A + E+ A + + + K+ + ++
Sbjct: 1172 --------REQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD 1223
Query: 467 ELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRHLQN 512
+ KQ L E E D ++R L ++ E + + + LE +++ LQ+
Sbjct: 1224 KNKQTL---EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQS 1266
Score = 57.8 bits (138), Expect = 2e-08
Identities = 128/564 (22%), Positives = 226/564 (40%), Gaps = 132/564 (23%)
Query: 72 ELRLREL-EEVKARAAQMEKTMRWWSDCTANWREKWSKVRAE----RNSAREEGR----- 121
E + R+L EE++A ++E T+ D TA +E +K E + + EE R
Sbjct: 1138 EKQKRDLGEELEALKTELEDTL----DSTATQQELRAKREQEVTVLKKALDEETRSHEAQ 1193
Query: 122 --QLRIKLEMAMKELSTL-----KKKQSLPPQKEALE---ANVTQDLKLPGFVEESCEHT 171
++R K A++EL+ + K +L K+ LE A++ +L++ G ++ EH
Sbjct: 1194 VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHK 1253
Query: 172 DQFQLSSQMHE-------------SIREYLVKRQFSTKEDTN--NKEQGVVIDSLKLSEE 216
+ +L +Q+ E + + + K Q + T N+ +G I K
Sbjct: 1254 KK-KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1312
Query: 217 MKPNL-DGVDLFNNGGSGNGETKTGLR-LKAINLPLENEVTE-----------ISALQVH 263
+ L D +L T LR L+ L++++ E IS L +
Sbjct: 1313 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1372
Query: 264 LDEFQKILWKEREMRTALE-------KEIERLESALSLWKWKYEELKESKPKNVKEFDIL 316
L + +K L ALE KEIE L Y++L+++K + +E D L
Sbjct: 1373 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 1432
Query: 317 LGQHNDEMQELSGNIKEE--------------SKSQNSKDRVICELR-----------AE 351
+ +++ Q +S K++ SK + +DR E R A
Sbjct: 1433 VVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL 1492
Query: 352 LERLQA----ENTSEWDKREI----------------LEREKQGLERENRRLKIQVKEME 391
E L+A E T++ K E+ LE+ K+ LE + +K Q++E+E
Sbjct: 1493 EEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELE 1552
Query: 392 ELL----DKKNRLSANSQS------PDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANI 441
+ L D K RL N Q+ D + +EK ++L H Y +
Sbjct: 1553 DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR 1612
Query: 442 AELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLD------- 494
A A ++ E ++K L L+ + +G + +L Q++ QR L+
Sbjct: 1613 ALAAAAKKKL---EGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD 1669
Query: 495 -------EEKERNENLETELRHLQ 511
E +++ ++LE +L LQ
Sbjct: 1670 EIFATAKENEKKAKSLEADLMQLQ 1693
Score = 55.1 bits (131), Expect = 2e-07
Identities = 102/464 (21%), Positives = 188/464 (40%), Gaps = 77/464 (16%)
Query: 72 ELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAM 131
EL +R +E K+R ++EK R +++ E+ + ++A+ +K+++A
Sbjct: 1038 ELEVRLKKEEKSRQ-ELEKLKRKLEGDASDFHEQIADLQAQI---------AELKMQLA- 1086
Query: 132 KELSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIREYLVKR 191
KK++ L L+ + Q + E H Q + R
Sbjct: 1087 ------KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARN----- 1135
Query: 192 QFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLE 251
K + ++ G +++LK E++ LD T+ LR K E
Sbjct: 1136 ----KAEKQKRDLGEELEALKT--ELEDTLDST-----------ATQQELRAKR-----E 1173
Query: 252 NEVTEISALQVHLDEFQKILWKE-REMRTALEKEIERLESALSLWKWKYEELKESKPKNV 310
EVT L+ LDE + + +EMR + +E L L +K L ++K
Sbjct: 1174 QEVT---VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE 1230
Query: 311 KEFDIL------LGQHNDEMQ----ELSGNIKEESKSQNSKDRVICELRAELERLQAENT 360
KE L LGQ E++ +L ++E + +R EL ++ +LQ E
Sbjct: 1231 KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVE 1290
Query: 361 SEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQID----- 415
S E + L ++ L Q+++ +ELL ++ R N + K+ Q++
Sbjct: 1291 SVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVST---KLRQLEEERNS 1347
Query: 416 ----LQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQG 471
L E+ + NL+ LN Q + +L + V+ E K+ + +E L Q
Sbjct: 1348 LQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQ 1407
Query: 472 LNQKE---DELDDSLNQIRK----LQRSLDEEKERNENLETELR 508
+K D+L+ + N++++ L LD +++ NLE + R
Sbjct: 1408 YEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQR 1451
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 73.9 bits (180), Expect = 3e-13
Identities = 105/506 (20%), Positives = 207/506 (40%), Gaps = 86/506 (16%)
Query: 77 ELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKL-------EM 129
ELE + AA ++K R R + +++ E +A+ E R L +L E
Sbjct: 1480 ELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEE 1539
Query: 130 AMKELSTLKKK----------------------QSLPPQKEALEANVTQDLKLPGFVEES 167
A++ L TLK++ Q L K+ALE ++ E +
Sbjct: 1540 ALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGA 1599
Query: 168 CEHTDQFQLSSQMHESIREYLVKRQFSTKEDT-----NNKEQGVVI-------------D 209
E + L Q+ S + V R+ + K++ N ++ V +
Sbjct: 1600 LELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNE 1659
Query: 210 SLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLENEVTEISALQVHLDEFQK 269
+L+L ++M+ +L+ ++L G + T+ + + L+ E Q DE Q+
Sbjct: 1660 ALRLKKKMEGDLNDLEL-QLGHATRQATEAQAATRLMQAQLKEE-------QAGRDEEQR 1711
Query: 270 ILWKEREMRTALEK-------EIERLESALSLWKWKYEELKESKPKNVKEFDILLGQHND 322
+ + E ALE+ E+E L +AL + ++ + + ++L Q+
Sbjct: 1712 LAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTG 1771
Query: 323 ----------EMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWDKREILERE 372
++ +LSG ++E ++ + + + + + E E D LER
Sbjct: 1772 LLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERM 1831
Query: 373 KQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDL---QEKNQELLNLQHA 429
K+ LE+ R L+ +++E E+ + + + + +L Q+K+ E L
Sbjct: 1832 KKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEAL----- 1886
Query: 430 YYKLNRQYQANIAELTHANNRVDQNEAE----VKKLRLRVEELKQGLNQKEDELDDSLNQ 485
K R+++ + EL + +N A V KL+ +V+ K+ + E + + +L +
Sbjct: 1887 --KGVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQANTNLAK 1944
Query: 486 IRKLQRSLDEEKERNENLETELRHLQ 511
RK Q LD+ +ER + ET+ L+
Sbjct: 1945 YRKAQHELDDAEERADMAETQANKLR 1970
Score = 56.2 bits (134), Expect = 7e-08
Identities = 51/236 (21%), Positives = 105/236 (44%), Gaps = 9/236 (3%)
Query: 273 KEREMRTALEKEIERLESALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIK 332
K +E+ LE E E + + L+ + K E+ K++ + + L + E Q +K
Sbjct: 967 KVKELSERLEDE-EEVNADLAARRRKLEDECTELKKDIDDLKLTLAKAEKEKQATENKVK 1025
Query: 333 EESKSQNSKDRVICELRAELERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEE 392
++ + D + L E + LQ + + E L + RL+ QV+++E
Sbjct: 1026 NLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLEC 1085
Query: 393 LLDKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVD 452
L+++ +L +++ K+ DL+ + + + +L + + +EL+ + RV+
Sbjct: 1086 SLEQEKKLRMDTERAKRKLEG-DLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVE 1144
Query: 453 -------QNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNE 501
Q + ++K+L+ R EEL++ L + Q + R L+E ER E
Sbjct: 1145 DEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLE 1200
Score = 55.1 bits (131), Expect = 2e-07
Identities = 98/456 (21%), Positives = 194/456 (42%), Gaps = 54/456 (11%)
Query: 72 ELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAM 131
+L LR +E+ + AQM+K ++ + A E ++ AER +AR + R + +
Sbjct: 1138 QLSLR-VEDEQLLGAQMQKKIK---ELQARAEELEEELEAER-AARARVEKQRAEAAREL 1192
Query: 132 KELSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCE--HTDQFQLSSQMHES-IREYL 188
+ELS + EA A+ Q E C + +L ++ E+ +R
Sbjct: 1193 EELSERLE--------EAGGASAGQ--------REGCRKREAELGRLRRELEEAALRHEA 1236
Query: 189 VKRQFSTKEDTNNKEQGVVIDSL-KLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAIN 247
K+ E G +DSL ++ ++++ + + + + N ET T + A
Sbjct: 1237 TVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEK 1296
Query: 248 LPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELKESKP 307
L E ++S ++ ++E Q+ L R L+ E L L E KE
Sbjct: 1297 LCRTYE-DQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLL--------EEKECLI 1347
Query: 308 KNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWDKRE 367
+ L Q ++EL ++EESK++++ + LR + + L+ ++ E + +
Sbjct: 1348 SQLSRGKALAAQ---SLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQA 1404
Query: 368 ILER--EKQGLERENRRLKIQ---VKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQE 422
L+R K E R K + ++ EEL + K +L+ Q ++ ++ N +
Sbjct: 1405 ELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQE-----AEEGVEAANAK 1459
Query: 423 LLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDS 482
+L+ A +L + + EL A + + + + L +EE ++ + + EL+ +
Sbjct: 1460 CSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAA 1519
Query: 483 LNQIR-------KLQRSLDEEKERNENLETELRHLQ 511
+ R +L+ +E E E L+ E ++LQ
Sbjct: 1520 QRESRGLGTELFRLRHGHEEALEALETLKRENKNLQ 1555
Score = 54.7 bits (130), Expect = 2e-07
Identities = 60/269 (22%), Positives = 120/269 (44%), Gaps = 34/269 (12%)
Query: 260 LQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELKESKPKNVKEFDILLGQ 319
L+ +++ + L +E+++R E+ +LE L L + + + K ++ + L +
Sbjct: 1076 LEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDK----QQLEEKLKK 1131
Query: 320 HNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWDKREILEREKQGLERE 379
+ E+ +LS +++E + I EL+A E L+ E +E R +E+++ RE
Sbjct: 1132 KDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARE 1191
Query: 380 NRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELLN--LQH-----AYYK 432
++E+ E L++ SA Q + + +L +EL L+H A +
Sbjct: 1192 -------LEELSERLEEAGGASAG-QREGCRKREAELGRLRRELEEAALRHEATVAALRR 1243
Query: 433 LNRQYQANIAELTHANNRVDQN-EAEVKKLRLRVEELKQGLNQK--------------ED 477
+ A + E + RV Q E E +LR+ V++L + ED
Sbjct: 1244 KQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYED 1303
Query: 478 ELDDSLNQIRKLQRSLDEEKERNENLETE 506
+L ++ ++ +LQR L + + L+TE
Sbjct: 1304 QLSEAKIKVEELQRQLADASTQRGRLQTE 1332
Score = 39.3 bits (90), Expect = 0.009
Identities = 55/249 (22%), Positives = 107/249 (42%), Gaps = 27/249 (10%)
Query: 270 ILWKEREMRTALEKEIERLESALSLWKWKYEELKESKPK------NVKEFDILLGQHNDE 323
+L + R+ R A + + S L + +Y+ L + N++ F+ + N
Sbjct: 821 VLEELRDQRLAKVLTLLQARSRGRLMRLEYQRLLGGRDALFTIQWNIRAFNAV---KNWS 877
Query: 324 MQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWDKREILEREKQGLERENRRL 383
+L +K +S +++ + LRAEL L+ + KR+ LE + +E L
Sbjct: 878 WMKLFFKMKPLLRSAQAEEE-LAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDL 936
Query: 384 KIQVK-EMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIA 442
+Q++ E + L D + R S++ L+ K +EL +L + + N A
Sbjct: 937 ALQLQAEQDNLADAEERCHL------LIKSKVQLEGKVKELSE------RLEDEEEVN-A 983
Query: 443 ELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNEN 502
+L +++ E+KK +++LK L + E E + N+++ L + E
Sbjct: 984 DLAARRRKLEDECTELKK---DIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVAR 1040
Query: 503 LETELRHLQ 511
L E + LQ
Sbjct: 1041 LTKEKKALQ 1049
>gi|46049114 M-phase phosphoprotein 1 [Homo sapiens]
Length = 1780
Score = 73.9 bits (180), Expect = 3e-13
Identities = 96/457 (21%), Positives = 191/457 (41%), Gaps = 63/457 (13%)
Query: 76 RELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAMKELS 135
++ EEV+ A++E +R + R + E + +EE +L ++ +ELS
Sbjct: 822 KKSEEVRPNIAEIED-IRVLQENNEGLRAFLLTIENELKNEKEEKAELNKQIVHFQQELS 880
Query: 136 TLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIREYLVKRQFST 195
L +K++L KE + D+ + + ++ +Q E I + + + +T
Sbjct: 881 -LSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQ-------EEKIMKLSNEIETAT 932
Query: 196 KEDTNNKEQ----GVVIDSLKLSEEMKPNLDGVDLFN-----NGGSGNGETKTGLRLKAI 246
+ TNN Q ID L+ + + + +DL N NG + T L L
Sbjct: 933 RSITNNVSQIKLMHTKIDELRTLDSVS-QISNIDLLNLRDLSNGSEEDNLPNTQLDLLGN 991
Query: 247 NLPLENEVTE---------------ISALQVHLDEFQKILWKEREMRTALEKEIERLESA 291
+ + +V E I A+ E K K+ LE++IE+L++
Sbjct: 992 DYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAE 1051
Query: 292 LSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAE 351
+ +K + LKE + KN D LL + +Q+L ++E++ + + + + + E +
Sbjct: 1052 VKGYKDENNRLKEKEHKNQ---DDLLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRA 1108
Query: 352 LERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKM 411
L L T K ++KE+E +L+ + ++S K+
Sbjct: 1109 LSELTQGVTC---------------------YKAKIKELETILETQKVECSHSA----KL 1143
Query: 412 SQIDLQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQG 471
Q D+ EK +L L+ + Q ++ N + + + E+ +L ++++K
Sbjct: 1144 EQ-DILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHL 1202
Query: 472 LNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELR 508
L KE+E + + + KL+ L R +NL+ +L+
Sbjct: 1203 LQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQ 1239
Score = 60.5 bits (145), Expect = 4e-09
Identities = 99/463 (21%), Positives = 201/463 (43%), Gaps = 98/463 (21%)
Query: 60 HSYNTNKWDICEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREE 119
HS W+ C+E+ ++ ++ Q+E+ ++ K++AE ++E
Sbjct: 1014 HSSIEAIWEECKEI----VKASSKKSHQIEEL-----------EQQIEKLQAEVKGYKDE 1058
Query: 120 GRQLRIKLEMAMKELSTLKKKQSLPPQ--KEALEANVTQDLKLPGFVEESCEHTDQFQLS 177
+L+ K +L LK+K++L Q +E E NVT D+++ VE +
Sbjct: 1059 NNRLKEKEHKNQDDL--LKEKETLIQQLKEELQEKNVTLDVQIQHVVEGK-------RAL 1109
Query: 178 SQMHESIREYLVK-RQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGE 236
S++ + + Y K ++ T +T E S KL +++
Sbjct: 1110 SELTQGVTCYKAKIKELETILETQKVECS---HSAKLEQDI------------------- 1147
Query: 237 TKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWK 296
L ++I L LE + E Q HL + K L++EI +L + L K
Sbjct: 1148 ----LEKESIILKLERNLKEF---QEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMK 1200
Query: 297 WKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELER-- 354
+ +E + N +E + L +ELS + +++QN L+A+L+R
Sbjct: 1201 HLLQLKEEEEETNRQETEKL-------KEELSAS---SARTQN--------LKADLQRKE 1242
Query: 355 -----LQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDF 409
L+ + T + + +++E + E++ L+I++ E+E+ KKN+ S +
Sbjct: 1243 EDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEK---KKNQCSQ-----EL 1294
Query: 410 KMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELK 469
M Q +Q+ ++L N ++ + I + A ++ E ++ +R+ +EE +
Sbjct: 1295 DMKQRTIQQLKEQLNN---------QKVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQE 1345
Query: 470 QGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRHLQN 512
Q +++ L+ L ++ +L L++ KE+ +LET+ N
Sbjct: 1346 QTQVEQDQVLEAKLEEVERLATELEKWKEKCNDLETKNNQRSN 1388
Score = 56.2 bits (134), Expect = 7e-08
Identities = 104/498 (20%), Positives = 211/498 (42%), Gaps = 84/498 (16%)
Query: 50 QSHAAHNFCAHSYNTNKWDICEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKV 109
+ AA + CA T + C EL+ +++ A++ KT + + K
Sbjct: 652 REEAAKDICATKVETEEATACLELKFNQIK------AELAKT-----------KGELIKT 694
Query: 110 RAERNSAREEGRQLRIKLEMAMKELST----LKKKQSLPPQKEALEANVTQDLKLPGFVE 165
+ E E L +LE + K++ T +K+ ++ QKE N Q+LK +E
Sbjct: 695 KEELKKRENESDSLIQELETSNKKIITQNQRIKELINIIDQKED-TINEFQNLK--SHME 751
Query: 166 ESCEHTDQFQLSSQM-------HESI-------------REYLVKRQFSTKEDTNNK--- 202
+ + D+ SS + +E++ R+ + + + E K
Sbjct: 752 NTFKCNDKADTSSLIINNKLICNETVEVPKDSKSKICSERKRVNENELQQDEPPAKKGSI 811
Query: 203 -EQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLR--LKAINLPLENEVTEISA 259
+ + K SEE++PN+ ++ E GLR L I L+NE E +
Sbjct: 812 HVSSAITEDQKKSEEVRPNIAEIEDIR----VLQENNEGLRAFLLTIENELKNEKEEKAE 867
Query: 260 LQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELKESKPKNVKEFDILLGQ 319
L + FQ+ L + L KE+++++S + EL K KN ++
Sbjct: 868 LNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDI---AIAELHVQKSKNQEQ------- 917
Query: 320 HNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQA-ENTSEWDKREILEREKQGLER 378
+++ +LS I+ ++S + I + +++ L+ ++ S+ ++L
Sbjct: 918 -EEKIMKLSNEIETATRSITNNVSQIKLMHTKIDELRTLDSVSQISNIDLL--------- 967
Query: 379 ENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYYK-LNRQY 437
N R E + L + + L N ++ + +QE N+E N H+ + + +
Sbjct: 968 -NLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRE--NSFHSSIEAIWEEC 1024
Query: 438 QANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQ-KEDE---LDDSLNQIRKLQRSL 493
+ + + ++++++ E +++KL+ V+ K N+ KE E DD L + L + L
Sbjct: 1025 KEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLKEKETLIQQL 1084
Query: 494 DEE-KERNENLETELRHL 510
EE +E+N L+ +++H+
Sbjct: 1085 KEELQEKNVTLDVQIQHV 1102
Score = 41.2 bits (95), Expect = 0.002
Identities = 75/345 (21%), Positives = 151/345 (43%), Gaps = 42/345 (12%)
Query: 77 ELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAMKELST 136
EL AR ++ ++ + A+ +EK + + + ++E +R + ++ +++
Sbjct: 1223 ELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINE 1282
Query: 137 LKKKQSLPPQKEALEANVTQDLKLP---GFVEESCEHTDQFQLSSQMHESIREYLVKRQF 193
L+KK++ Q+ ++ Q LK VEE+ + ++ + E I E + R
Sbjct: 1283 LEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIEDM--RMT 1340
Query: 194 STKEDTNNKEQGVVIDSLKLS---------EEMKPNLDGVDLFNNGGSG-NGETKTGLRL 243
+++ EQ V+++ KL E+ K + ++ NN S E T +
Sbjct: 1341 LEEQEQTQVEQDQVLEA-KLEEVERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLG 1399
Query: 244 KAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELK 303
K NL E + +E Q + + +K L +E+ M KE E + + KY E +
Sbjct: 1400 KLTNLQDELQESE----QKYNADRKKWL-EEKMMLITQAKEAENIRNKEMK---KYAEDR 1451
Query: 304 ESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEW 363
E K E +IL Q ++ +L K + +D+++ L +L+ L + N +
Sbjct: 1452 ERFFKQQNEMEILTAQLTEKDSDL-------QKWREERDQLVAALEIQLKALISSNVQKD 1504
Query: 364 DKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPD 408
++ E L+R + E +++ Q+ ++ K R+S S PD
Sbjct: 1505 NEIEQLKR----IISETSKIETQIMDI-----KPKRIS--SADPD 1538
Score = 35.4 bits (80), Expect = 0.13
Identities = 53/253 (20%), Positives = 106/253 (41%), Gaps = 30/253 (11%)
Query: 270 ILWKEREMRTALEKE--IERLESALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQEL 327
I W E + +E E +E LE+A + + L E K ++E + ++E ++L
Sbjct: 520 ISW-ENSLEDLMEDEDLVEELENAEETQNVETKLLDEDLDKTLEENKAFIS--HEEKRKL 576
Query: 328 SGNIKEESKS--QNSKDRVICELRAELERLQAENTSEWDKREILEREKQGLERE------ 379
I++ K K+++ E + E + E T W +RE +E ERE
Sbjct: 577 LDLIEDLKKKLINEKKEKLTLEFKIR-EEVTQEFTQYWAQREADFKETLLQEREILEENA 635
Query: 380 NRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQA 439
RRL I ++L+ K + + + D ++++ +E A L ++
Sbjct: 636 ERRLAI----FKDLVGKCD--TREEAAKDICATKVETEE----------ATACLELKFNQ 679
Query: 440 NIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKER 499
AEL + + + E+KK + L Q L ++ +I++L +D++++
Sbjct: 680 IKAELAKTKGELIKTKEELKKRENESDSLIQELETSNKKIITQNQRIKELINIIDQKEDT 739
Query: 500 NENLETELRHLQN 512
+ H++N
Sbjct: 740 INEFQNLKSHMEN 752
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 73.6 bits (179), Expect = 4e-13
Identities = 102/495 (20%), Positives = 218/495 (44%), Gaps = 64/495 (12%)
Query: 77 ELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKL-------EM 129
++E + AA ++K R + A W+ K + +AE ++ +E R L +L E
Sbjct: 1432 DVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEE 1491
Query: 130 AMKELSTLKKKQSLPPQKEA-LEANVTQDLKLPGFVEESCEHTDQFQLSSQM-------- 180
A+ +L T+K++ Q+ A L + ++ K +E+S + + + Q+
Sbjct: 1492 ALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAA 1551
Query: 181 --HES---IREYLVKRQFSTKEDTNNKEQGVVIDSLKLS-----EEMKPNLDGVDLFNNG 230
HE +R L Q ++ D E+ I+ LK + E M+ LD N
Sbjct: 1552 LEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNE 1611
Query: 231 GSGNGETKTG------LRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKE 284
+ G ++L N + + ++Q L + Q L + L+++
Sbjct: 1612 AIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQ 1671
Query: 285 IERLESALSLWKWKYEELKES-----KPKNVKEFDILLGQHNDEMQELSGNIKEESKSQN 339
+ +E +L + + EEL+ + + + + E ++L N+ +Q L ++
Sbjct: 1672 LAIVERRANLLQAEVEELRATLEQTERARKLAEQELL--DSNERVQLLHTQNTSLIHTKK 1729
Query: 340 SKDRVICELRAELERLQ--AENTSEWDKREI---------LEREKQG---LERENRRLKI 385
+ + +L++E+E A N E K+ I L++E+ LER + L+
Sbjct: 1730 KLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQ 1789
Query: 386 QVKEMEELLDKKNRLSANS-----QSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQAN 440
VK+++ LD+ +L+ Q + ++ +++ + + ++ N + K R+Y+
Sbjct: 1790 TVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESV--KGLRKYERR 1847
Query: 441 IAELTHANNRVDQNEAE----VKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEE 496
+ ELT+ + +N V KL+++V+ K+ + +++ + L + RK Q L+E
Sbjct: 1848 VKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEA 1907
Query: 497 KERNENLETELRHLQ 511
+ER + E+++ L+
Sbjct: 1908 EERADIAESQVNKLR 1922
Score = 69.3 bits (168), Expect = 8e-12
Identities = 94/464 (20%), Positives = 197/464 (42%), Gaps = 54/464 (11%)
Query: 84 RAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAMKELSTLK----- 138
++A+ EK M A +E++ K + E + + ++L KL ++E + L+
Sbjct: 842 KSAETEKEM-------ATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQA 894
Query: 139 KKQSLPPQKEALEANVTQDLKLPGFVEESCEHT-DQFQLSSQMHESIREYLVKRQFSTKE 197
+ ++L +E + + +L ++E E D+ ++++++ R+ L K+
Sbjct: 895 ESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRK-LEDECSELKK 953
Query: 198 DTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGET--KTGLRLKAINLPLENEVT 255
D ++ E + K+ +E + V SG ET K KA+ + +
Sbjct: 954 DIDDLE----LTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALD 1009
Query: 256 EISA--------------LQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEE 301
++ A L+ +++ + L +E+++R LE+ +LE L L + +
Sbjct: 1010 DLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILD 1069
Query: 302 LKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTS 361
L+ K ++ D L + + E +L +++E + I EL+A +E L+ E +
Sbjct: 1070 LENDK----QQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEA 1125
Query: 362 EWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQ 421
E R E+++ RE L +++E + + L+ ++ K+ + DL+E
Sbjct: 1126 ERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRR-DLEEATL 1184
Query: 422 ELLNLQHAYYKLNRQYQANIAELTHANNRVDQN-EAEVKKLRLRVEELKQGLNQK----- 475
+ + A K + A + E RV Q E E + +L +++L +
Sbjct: 1185 QHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKA 1244
Query: 476 ---------EDELDDSLNQIRKLQRSLDEEKERNENLETELRHL 510
ED+L ++ + ++QRSL E + L+TE L
Sbjct: 1245 NLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGEL 1288
Score = 57.0 bits (136), Expect = 4e-08
Identities = 99/453 (21%), Positives = 193/453 (42%), Gaps = 75/453 (16%)
Query: 68 DICEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWS-------KVRAERNSAREEG 120
D C EL+ +++++++ A++EK + N E+ S K+ E+ + +E
Sbjct: 946 DECSELK-KDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAH 1004
Query: 121 RQLRIKLEMAMKELSTLKK-KQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQ 179
+Q L+ ++++L K K L Q E LE+++ Q+ KL +E +
Sbjct: 1005 QQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERN------------ 1052
Query: 180 MHESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKT 239
+ L Q S + N+K+Q L E +K + E
Sbjct: 1053 -KRKLEGDLKLAQESILDLENDKQQ--------LDERLKKK--DFEYCQLQSKVEDEQTL 1101
Query: 240 GLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKY 299
GL+ + +I LQ ++E ++ + ER R EK+ R + A L
Sbjct: 1102 GLQFQK----------KIKELQARIEELEEEIEAERATRAKTEKQ--RSDYAREL----- 1144
Query: 300 EELKE--SKPKNVKEFDILLGQHND-EMQELSGNIKEESKSQNSKDRVICELRAELERLQ 356
EEL E + V I L + + E +L +++E + + + A L +
Sbjct: 1145 EELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEA-------MVAALRKKH 1197
Query: 357 AENTSEWDKR-EILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQID 415
A++ +E ++ + L+R KQ LE+E K+++ ++ ++ ++ AN + +I
Sbjct: 1198 ADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKAN-------LEKIC 1250
Query: 416 LQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQK 475
++Q L A K N + Q +++ELT +R+ + E +L ++EE + ++Q
Sbjct: 1251 RTLEDQ----LSEARGK-NEEIQRSLSELTTQKSRL---QTEAGELSRQLEEKESIVSQL 1302
Query: 476 EDELDDSLNQIRKLQRSLDEEKERNENLETELR 508
Q +L+R L+EE + L L+
Sbjct: 1303 SRSKQAFTQQTEELKRQLEEENKAKNALAHALQ 1335
Score = 55.8 bits (133), Expect = 9e-08
Identities = 87/460 (18%), Positives = 191/460 (41%), Gaps = 53/460 (11%)
Query: 78 LEEVKARAAQMEKTMRWWSDCTANWREK-------WSKVRAERNSAREEGRQLRIKLEMA 130
+E V A +EK R D + R K S++ +++ + E +L +LE
Sbjct: 1236 MESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEK 1295
Query: 131 MKELSTLKK-KQSLPPQKEALEANVTQDLKLPGFVEESCEHT--------DQFQLSSQMH 181
+S L + KQ+ Q E L+ + ++ K + + + + +Q++ +
Sbjct: 1296 ESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGK 1355
Query: 182 ESIREYLVKR-----QFSTKEDTNNKEQGVVIDSLK--LSEEMKPNLDGVDLFNNGGSGN 234
++ L K Q+ TK +T+ ++ ++ K L++ ++ + + V+ N +
Sbjct: 1356 AELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASL 1415
Query: 235 GETKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSL 294
+TK L+ E+ L V ++ + + AL+K+ + L+
Sbjct: 1416 EKTKQRLQ------------GEVEDLMVDVE-------RANSLAAALDKKQRNFDKVLAE 1456
Query: 295 WKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELER 354
WK K EE + ++KE L + E+ +L +E + R L E+
Sbjct: 1457 WKTKCEESQAELEASLKESRSL----STELFKLKNAYEEALDQLETVKRENKNLEQEIAD 1512
Query: 355 LQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKM-SQ 413
L + LE+ ++ +E E +++ ++E E L+ + Q ++ S+
Sbjct: 1513 LTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSE 1572
Query: 414 ID--LQEKNQELLNLQHAYYKLNRQYQANI-AELTHANNRV---DQNEAEVKKLRLRVEE 467
ID + EK++E+ L+ Y + Q+ + AE+ N + + E ++ ++ +++
Sbjct: 1573 IDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSH 1632
Query: 468 LKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETEL 507
+ + L Q++ Q LD+ E+L+ +L
Sbjct: 1633 ANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQL 1672
Score = 40.8 bits (94), Expect = 0.003
Identities = 89/396 (22%), Positives = 160/396 (40%), Gaps = 56/396 (14%)
Query: 77 ELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEG--RQLRIKLEMAMKEL 134
E+E++K + +TM+ D E S+ A R + EG ++ I+L A ++
Sbjct: 1583 EIEQLKRNYQRTVETMQSALDA-----EVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQA 1637
Query: 135 S-TLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIREYLVKRQF 193
+ TLK +S+ Q + + ++ L+ ++E ++ ++ + V+
Sbjct: 1638 AETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVER-------RANLLQAEVEELR 1690
Query: 194 STKEDTNNKEQGVVIDSLKLSE-EMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLEN 252
+T E T KL+E E+ + + V L + + TK L + L E
Sbjct: 1691 ATLEQTERAR--------KLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEV 1742
Query: 253 EVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELKESKPKNVKE 312
E A ++ +K + M L+KE + E +K++ + VK+
Sbjct: 1743 EDASRDARNAE-EKAKKAITDAAMMAEELKKEQDTSAHL--------ERMKKNLEQTVKD 1793
Query: 313 FDILLGQHN-DEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWDKREILER 371
QH DE ++L+ +K K + I EL ELE Q +NT
Sbjct: 1794 L-----QHRLDEAEQLA--LKGGKKQIQKLETRIRELEFELEGEQKKNTES--------- 1837
Query: 372 EKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYY 431
+GL + RR+K + EE D+KN L ++ + + +E +A+
Sbjct: 1838 -VKGLRKYERRVKELTYQSEE--DRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHL 1894
Query: 432 KLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEE 467
R+ Q EL A R D E++V KLR + +
Sbjct: 1895 TKFRKAQH---ELEEAEERADIAESQVNKLRAKTRD 1927
>gi|4502443 dystonin isoform 1e precursor [Homo sapiens]
Length = 2649
Score = 73.6 bits (179), Expect = 4e-13
Identities = 92/424 (21%), Positives = 186/424 (43%), Gaps = 46/424 (10%)
Query: 117 REEGRQLRI---KLEMAMKELSTLKK--------KQSLPPQKEALEANVTQDLKLPGFVE 165
RE GRQL K E AM+E S LKK +SL +K L+ V + + E
Sbjct: 1439 RELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAE 1498
Query: 166 ESCEHTDQFQLSSQMHESIREYLVKR-QFSTKEDTNNKEQ-----GVVIDSLKLSEEMKP 219
++ +H L+SQ+H E ++R Q ++ + KEQ ++ ++K +E
Sbjct: 1499 KNIQH-----LNSQIHSFRDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKE--- 1550
Query: 220 NLDGVDLFNNGGSGNGETKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRT 279
N D + N + E L+ K L +N T++ ++ + +L K+
Sbjct: 1551 NNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQ----- 1605
Query: 280 ALEKEIERLESALSLWKWKYEELKESKPKNVK---EFDILLGQHNDEMQELSGNIKEESK 336
+++ E L+ +K + E K K +F + +++ + + E +
Sbjct: 1606 TIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQ 1665
Query: 337 SQNSKDRVICELRAELERLQAE-NTSEWDKR----EILEREKQGLERENRRLKIQ----V 387
+ ++ +I + E+ L AE N S+ +KR ++ ++ Q E NR K+Q +
Sbjct: 1666 KCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHL 1725
Query: 388 KEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAELTHA 447
K +EE + + + +S FK S + ++K ++L+ + + + L
Sbjct: 1726 KTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRLDFVSLQQE 1785
Query: 448 NNRVDQN----EAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENL 503
N+R +N E +K+L ++++ ++ + Q + + + +KL+ L +K ENL
Sbjct: 1786 NSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENL 1845
Query: 504 ETEL 507
+ ++
Sbjct: 1846 KQKM 1849
Score = 42.7 bits (99), Expect = 8e-04
Identities = 66/288 (22%), Positives = 125/288 (43%), Gaps = 53/288 (18%)
Query: 248 LPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELKESKP 307
LP E++ +S LQ ++F L +E + +I +LE +++ K Y+EL +S
Sbjct: 675 LPGEHQQV-LSNLQSRFEDF---LEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAE 730
Query: 308 KNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWDKRE 367
+ +E + +N + E+ NI+ + +N +DR+I ++R LER +
Sbjct: 731 REEQEESV----YNLYISEVR-NIR--LRLENCEDRLIRQIRTPLERDDLHESVF----R 779
Query: 368 ILEREKQGLERENRRLKIQV------------------------KEMEELLDKKNRLSAN 403
I E+EK L++E RLK + E+ +L N++ +
Sbjct: 780 ITEQEK--LKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSM 837
Query: 404 SQSPDFKMSQIDLQEKNQELLNLQHAYYKLNR-QYQANIAELTHANNRVDQNEAEVKKLR 462
S + K+ ++L KN + Y+ + +A IA+ + N + + +K+ R
Sbjct: 838 SSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI----STLKQWR 893
Query: 463 LRVEELKQGLNQKEDEL-------DDSLNQIRKLQRSLDEEKERNENL 503
V+E +Q + EDEL D+ ++ D KE+ + L
Sbjct: 894 SEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQL 941
Score = 40.0 bits (92), Expect = 0.005
Identities = 76/406 (18%), Positives = 170/406 (41%), Gaps = 43/406 (10%)
Query: 119 EGRQLRIKLEMAMKELSTLKKKQS-----LPPQKEALEANVTQDLKLPGFVEESCEHTDQ 173
E +L K+ + ++ LKK++S LP +EA E + + + VE+ +
Sbjct: 1132 ENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQQRN---VEDISLQKIR 1188
Query: 174 FQLSSQMHESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSG 233
+ ++ + E +V+ + + + + Q + I++ ++ NL F N
Sbjct: 1189 AESEAKQYRRELETIVREKEAAERELERVRQ-LTIEAEAKRAAVEENLLN---FRNQLEE 1244
Query: 234 NGETKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALS 293
N T+ + + L+ + ++ L+ ++ + L ++R+ L K I+++E L+
Sbjct: 1245 NTFTR-----RTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLA 1299
Query: 294 LWKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESK-----SQNSKDRVICEL 348
K E K +KE + + ++ E+ +E + +Q + R + L
Sbjct: 1300 FQKQVAE-------KQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAVTGL 1352
Query: 349 RAELERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPD 408
+ E ++ +AE L+++ L NR+ + ++M EL + N L S +
Sbjct: 1353 QQEHDKQKAEE---------LKQQVDELTAANRKAE---QDMRELTYELNALQLEKTSSE 1400
Query: 409 FKMSQID--LQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVE 466
K + L E N L L+ + ++ + +L +++Q + ++
Sbjct: 1401 EKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEAS 1460
Query: 467 ELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRHLQN 512
+LK+ + EL+ ++ KLQR +D + E ++HL +
Sbjct: 1461 DLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNS 1506
Score = 40.0 bits (92), Expect = 0.005
Identities = 62/310 (20%), Positives = 125/310 (40%), Gaps = 32/310 (10%)
Query: 214 SEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWK 273
+EE+K +D + N + T L A+ L + + L+ LDE L
Sbjct: 1361 AEELKQQVDELTAANRKAEQDMRELT-YELNALQLEKTSSEEKARLLKDKLDETNNTL-- 1417
Query: 274 EREMRTALEKEIERLESALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQ-------E 326
L+ E+ER + A + + EL + + + + + +D + E
Sbjct: 1418 -----RCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLE 1472
Query: 327 LSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWDKREILEREK-QGLERENRRLKI 385
L E+ K Q DR+ + +Q N+ R+ E E+ Q +R++ LK
Sbjct: 1473 LESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKELERLQICQRKSDHLKE 1532
Query: 386 QVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAELT 445
Q ++ E L + A ++ D +Q N+EL L ++ + ELT
Sbjct: 1533 QFEKSHEQL--LQNIKAEKENND------KIQRLNEELEKSNECAEMLKQK----VEELT 1580
Query: 446 HANNR----VDQNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNE 501
NN + + +AE + + L + ++Q + + D +Q+R L ++ + +
Sbjct: 1581 RQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQ 1640
Query: 502 NLETELRHLQ 511
+ + +++ L+
Sbjct: 1641 DFQRKIKCLE 1650
Score = 39.3 bits (90), Expect = 0.009
Identities = 77/370 (20%), Positives = 158/370 (42%), Gaps = 43/370 (11%)
Query: 78 LEEVKARAAQMEKTMRW------WSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAM 131
L+ +KA +K R ++C ++K ++ + N + ++++ + E +
Sbjct: 1542 LQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAESENIV 1601
Query: 132 KELSTLKKKQSLPPQKEAL--EANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIREYLV 189
E KQ++ + EAL +A+ +D +L E + T Q + + + E L
Sbjct: 1602 LE------KQTIQQRCEALKIQADGFKD-QLRSTNEHLHKQTKTEQDFQRKIKCLEEDLA 1654
Query: 190 KRQFSTKEDTNN-KEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINL 248
K Q E +Q ++I + K +E++ NL+ + GE K L+ +
Sbjct: 1655 KSQNLVSEFKQKCDQQNIIIQNTK--KEVR-NLNAELNASKEEKRRGEQKVQLQQAQVQ- 1710
Query: 249 PLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELKESKPK 308
L N + ++ ++HL ++ + R+M ++E + + + ++ K E+L ESK
Sbjct: 1711 ELNNRLKKVQD-ELHLKTIEEQM-THRKM-VLFQEESGKFKQSAEEFRKKMEKLMESKVI 1767
Query: 309 NVKEFD------ILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSE 362
+ + L Q N QE N K + +R + + R ++++ Q +
Sbjct: 1768 TENDISGIRLDFVSLQQENSRAQE---NAKLCETNIKELERQLQQYREQMQQGQHMEANH 1824
Query: 363 WDKREILERE----KQGLERENRRLKIQVKEMEELL-------DKKNRLSANSQSPDFKM 411
+ K + LE E K+ +E +++ Q+KE E L KK+ + PDF+M
Sbjct: 1825 YQKCQKLEDELIAQKREVENLKQKMDQQIKEHEHQLVLLQCEIQKKSTAKDCTFKPDFEM 1884
Query: 412 SQIDLQEKNQ 421
+ + Q +
Sbjct: 1885 TVKECQHSGE 1894
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 73.2 bits (178), Expect = 5e-13
Identities = 96/468 (20%), Positives = 203/468 (43%), Gaps = 66/468 (14%)
Query: 77 ELEEVKARAAQMEKTMRWWSD---CTANWREKWSKVRAERNSAREEGRQLRIKLEMAMKE 133
+LE+ + + EKTM C + E ++ E ++ E ++ +K + A+K
Sbjct: 776 QLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTE---SKGEMKKENMKKDEALKA 832
Query: 134 LSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHE------SIREY 187
L ++++ ++ D L EE H +Q + + + E S Y
Sbjct: 833 LQNQVSEETIKVRQ--------LDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVY 884
Query: 188 LVKRQFSTKEDT--NNKEQGVVID-SLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLK 244
++++ K + EQ V++ +L+ ++M + NG + +TK ++
Sbjct: 885 CLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQ----ETIRNGELEDTQTKLEKQVS 940
Query: 245 AINLPLENEVTEISALQVHLDEFQKILWKEREMR---------TALEKEIE--RLESALS 293
+ L+ + + ++E + E +++ TA + +IE + + LS
Sbjct: 941 KLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELS 1000
Query: 294 LWKWKYEELK---ESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRA 350
+ + LK E+K ++ + D++L Q E+++ + +KE K Q+S +
Sbjct: 1001 KMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTE-------- 1052
Query: 351 ELERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDK------KNRLSANS 404
E T KRE+LE E Q E + Q++E+ ++L K + +
Sbjct: 1053 ------TELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKD 1106
Query: 405 QSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLR 464
+ + + ++++++K QELL + A + N + + A++TH + + ++ E+++ +
Sbjct: 1107 LTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQ---K 1163
Query: 465 VEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRHLQN 512
+ +L+ L + E EL + QI L L KE+ E E LQN
Sbjct: 1164 IIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLR--EKEFIMLQN 1209
Score = 57.8 bits (138), Expect = 2e-08
Identities = 88/409 (21%), Positives = 174/409 (42%), Gaps = 54/409 (13%)
Query: 104 EKWSKVRAERNSAREEGRQLRIKLEMAMKELSTLKKKQSLPPQKEALEANVTQDLKLPGF 163
EK K+R+ + E ++ + E A K L++ + + Q E LEA + + +
Sbjct: 729 EKNEKIRSLETNINTEHEKICLAFEKAKK--IHLEQHKEMEKQIERLEAQLEKKDQQFKE 786
Query: 164 VEESCEHTDQFQLSSQMH-ESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLD 222
E++ Q + Q H ES+ L + + K++ K++ + ++SEE
Sbjct: 787 QEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEET----- 841
Query: 223 GVDLFNNGGSGNGETKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALE 282
K A+ + E V ++ L+ + ++F+K L K+ E L+
Sbjct: 842 --------------IKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQ 887
Query: 283 KEIERLESALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKD 342
KE+ K K L+E+ +NV L Q QE N + E +Q +
Sbjct: 888 KEL----------KIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELED-TQTKLE 936
Query: 343 RVICELRAELERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSA 402
+ + +L EL++ Q E+++E ++ + E E + +R K+ EL ++
Sbjct: 937 KQVSKLEQELQK-QRESSAEKLRKMEEKCESAAHEADLKRQKVI-----ELTGTARQV-- 988
Query: 403 NSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLR 462
+I++ + +EL ++ L R + L+ + +DQ + E++K
Sbjct: 989 ----------KIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKT 1038
Query: 463 LRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRHLQ 511
V+EL++ + E EL ++L + L+ L + + L++ LR LQ
Sbjct: 1039 NAVKELEKLQHSTETELTEALQKREVLETEL---QNAHGELKSTLRQLQ 1084
Score = 52.0 bits (123), Expect = 1e-06
Identities = 93/454 (20%), Positives = 187/454 (41%), Gaps = 68/454 (14%)
Query: 72 ELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRI---KLE 128
+L+ +++ E+ A Q++ M ++E+ SK+ E + +G + +L+
Sbjct: 972 DLKRQKVIELTGTARQVKIEMD-------QYKEELSKMEKEIMHLKRDGENKAMHLSQLD 1024
Query: 129 MAMKELST-LKKKQSLPPQKEAL----EANVTQDLKLPGFVEESCEHTD-QFQLSSQMHE 182
M + + T L+KK + + E L E +T+ L+ +E ++ + + + + +
Sbjct: 1025 MILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQ 1084
Query: 183 SIREYLVKRQFSTKED-TNNKEQGVVIDSLKLS-EEMKPNLDGVDLFNNGGSGNGETKTG 240
+R+ L K Q S +E T K+ + K+ E+ K L +D
Sbjct: 1085 ELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQ-------------- 1130
Query: 241 LRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYE 300
LK N L+ +++ L + + RE R +E++I +LE L
Sbjct: 1131 -ALKERNWELKQRAAQVTHLDMTI----------REHRGEMEQKIIKLEGTL-------- 1171
Query: 301 ELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQ---- 356
E +KE + + ND++Q ++E+ ++ I +L+ E+ER Q
Sbjct: 1172 ---EKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMK 1228
Query: 357 -AENTSEWDKREILEREKQGLE--RENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQ 413
E+ + ++ I + K+ ++ +E R + QV+ L + +Q ++S
Sbjct: 1229 EMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSS 1288
Query: 414 IDLQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLN 473
+L++ Q L + A+ H R+ +AE+KKL VE LK+ +
Sbjct: 1289 -ELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARM---QAEIKKLSAEVESLKEAYH 1344
Query: 474 QKEDELDDSLNQIRKLQRSLDEEKERNENLETEL 507
E+ K + S D +K + L +L
Sbjct: 1345 M---EMISHQENHAKWKISADSQKSSVQQLNEQL 1375
Score = 47.4 bits (111), Expect = 3e-05
Identities = 98/419 (23%), Positives = 180/419 (42%), Gaps = 61/419 (14%)
Query: 103 REKWSKVRAERNSAREEGRQLRIKLEMAMKELSTLKKKQSLPPQKEALEANVTQDLKLPG 162
REK +K+R + + L K E EL+ + K S+ LE+ Q +P
Sbjct: 235 REKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSM------LESAQQQAASVP- 287
Query: 163 FVEESCEHTDQFQLSSQMHESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLD 222
+EE + + ++S+Q + +RE K + S K KEQ SL+ S+E L
Sbjct: 288 ILEEQIINLEA-EVSAQ-DKVLREAENKLEQSQKM-VIEKEQ-----SLQESKEECIKLK 339
Query: 223 GVDLFNNGGSGNGETKTGLRL-KAINLPLENEVTEISALQVH----LDEFQKILWKEREM 277
VDL +TK G R + N L N A Q + ++ +K+ +E +
Sbjct: 340 -VDLLE-------QTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEIL 391
Query: 278 R---TALEKEIERLESALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEE 334
T EKE +RL+ L+K + E LKE +++E + N KE+
Sbjct: 392 ERNLTNCEKENKRLQERCGLYKSELEILKEKLR---------------QLKEENNNGKEK 436
Query: 335 SKSQNSKDRVICELRAELERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEELL 394
+ K+ + E + + SE + ++ + R+K L ENR LK++V E L
Sbjct: 437 LRIMAVKNSEVMAQLTESRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQNERL 496
Query: 395 DKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQN 454
D + + + S+++L+ + + L + + +++ +N+ D+
Sbjct: 497 DLCQQ--------EIESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRC 548
Query: 455 EAEVKKLRLRVEELKQGLNQKEDELDD-----SLNQIRKLQRSLDEEKERNE--NLETE 506
+ +L + EL+ L KE E+ + NQ+ + + ++ +E ++ +LETE
Sbjct: 549 IGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETE 607
Score = 33.5 bits (75), Expect = 0.48
Identities = 32/162 (19%), Positives = 75/162 (46%), Gaps = 11/162 (6%)
Query: 356 QAENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKN----RLSANSQSPDFKM 411
+AEN E ++ ++E+E+ E + +K++V +E+ K R A + +
Sbjct: 309 EAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAERQRNEALYNAEELSK 368
Query: 412 SQIDLQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQN----EAEVKKLRLRVEE 467
+ ++K E L A ++ + N+ N R+ + ++E++ L+ ++ +
Sbjct: 369 AFQQYKKKVAEKLEKVQAEEEI---LERNLTNCEKENKRLQERCGLYKSELEILKEKLRQ 425
Query: 468 LKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRH 509
LK+ N +++L + ++ L E ++ LE+EL +
Sbjct: 426 LKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELEN 467
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 72.0 bits (175), Expect = 1e-12
Identities = 106/471 (22%), Positives = 212/471 (45%), Gaps = 74/471 (15%)
Query: 101 NWREKWSKVRAERNSAREEGRQLRI-KLEMAMKELSTLKKKQSLPPQKEALEANVTQDLK 159
N + + +RA+ ++ + QLR K EM +K LK+K L + EALE +D +
Sbjct: 495 NIESELNSLRADYDNLVLDYEQLRTEKEEMELK----LKEKNDLD-EFEALERKTKKDQE 549
Query: 160 LPGFVEES-----CEHTDQFQLSSQMHESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLS 214
+ E S +H + + + S + L++ KED K Q IDS KL
Sbjct: 550 MQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLRE----KEDQIKKLQEY-IDSQKLE 604
Query: 215 E---EMKPNLDGVD--------LFNNGGSGNGETKTGLRLKAINLPLENEVTEISALQVH 263
++ +L+ ++ LF+ + L++ NL L+ ++ E++
Sbjct: 605 NIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQ 664
Query: 264 LDE----FQKILWKEREMRTALEKEIERLESALSLWKWKYEELKESK-PKNVKEFDILLG 318
++ +Q L +++M+ LEKE++ + ++ K L + K PK++ L G
Sbjct: 665 MENDIQLYQSQLEAKKKMQVDLEKELQSAFNEIT----KLTSLIDGKVPKDLLCNLELEG 720
Query: 319 QHNDEMQELSGNIKEESKSQNSKDRVICELRA---ELERLQAENTSEWDKREILEREKQG 375
+ D +EL+ + EE+++ + ++ EL++ E+ERL+ E + ++ I+ EK
Sbjct: 721 KITDLQKELNKEV-EENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDK 779
Query: 376 LERENRRLKIQVKEMEELLDK---------KNRLSANSQSPDFKMSQIDLQEK------- 419
L E + +V+ + E + K N S + + +FK +D ++K
Sbjct: 780 LFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEE 839
Query: 420 ----NQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQK 475
NQE++NL K + A EL++ + + EV++ +E+LK+ L +
Sbjct: 840 NERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENR 899
Query: 476 E--------------DELDDSLNQIRKLQRSLDEEKERNENLETELRHLQN 512
+ ++L +L +++ L + D+ K+ E+L+ E L++
Sbjct: 900 DSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKS 950
Score = 61.2 bits (147), Expect = 2e-09
Identities = 100/426 (23%), Positives = 179/426 (42%), Gaps = 86/426 (20%)
Query: 99 TANWREKWSKVRAERNSAREEGRQLRIKLEMAMKELSTLKKKQSLPPQK--EALEA--NV 154
T +EK +V+ N E QL+ +LE L T++++++L +K + LE +
Sbjct: 872 TQELQEKTREVQERLN----EMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTL 927
Query: 155 TQDLKLPGFVEESCEHTDQFQLSSQMHESIREYLVKRQFSTKEDTNN-----KEQGVVID 209
TQ+ ++ES + ++ QL S +H++ V T+E N K+ I+
Sbjct: 928 TQEKDDLKQLQESLQ-IERDQLKSDIHDT-----VNMNIDTQEQLRNALESLKQHQETIN 981
Query: 210 SLK--LSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLENEVTEISALQVHLDEF 267
+LK +SEE+ NL + GETK + K + + D+
Sbjct: 982 TLKSKISEEVSRNLHMEE-------NTGETKDEFQQKMVGI----------------DKK 1018
Query: 268 QKILWKEREMRTALEKEIERLESALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQEL 327
Q + K + TA K+ E +E ++ E+ E +L E ++L
Sbjct: 1019 QDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEK---------NELQQMLESVIAEKEQL 1069
Query: 328 SGNIKEESKSQNSKDRVICELRAELERLQAENTSEWDKREILEREKQGLERENRRLKIQV 387
++KE + + L EL++ Q EI+ +EK ++ L
Sbjct: 1070 KTDLKENIEMTIENQEELRLLGDELKKQQ----------EIVAQEKNHAIKKEGELS--- 1116
Query: 388 KEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAELTHA 447
+ + L + + +L SQ LQEK Q+LLN+Q ++ Q I E+ +
Sbjct: 1117 RTCDRLAEVEEKLKEKSQQ---------LQEKQQQLLNVQEEMSEM----QKKINEIENL 1163
Query: 448 NNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETEL 507
N + E ++ + EL Q LN+ +E+ S+ + RK+ KE ++ ETE
Sbjct: 1164 KNELKNKELTLEHMETERLELAQKLNENYEEVK-SITKERKVL------KELQKSFETER 1216
Query: 508 RHLQNW 513
HL+ +
Sbjct: 1217 DHLRGY 1222
Score = 60.1 bits (144), Expect = 5e-09
Identities = 94/468 (20%), Positives = 215/468 (45%), Gaps = 51/468 (10%)
Query: 71 EELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMA 130
E+ ++++ EV+ + ++++ + + SK+ N +E +++I +
Sbjct: 1533 EQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMI--- 1589
Query: 131 MKELSTLKKKQ-SLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIREYL- 188
KE +K+ Q +L +++ L+ N + + ++ES E QF + ++E+ +
Sbjct: 1590 -KEKEEMKRVQEALQIERDQLKENTKE---IVAKMKESQEKEYQFLKMTAVNETQEKMCE 1645
Query: 189 ---VKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKA 245
+K QF T++ + + ++++L++ + NL+ + + L+++
Sbjct: 1646 IEHLKEQFETQK---LNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVER 1702
Query: 246 INLP--LENEVT-------EISALQVHLDEFQKILWKEREMRTA-------LEKEIERLE 289
L L +T E+ + +HL E Q+ + K R + + ++K++E
Sbjct: 1703 DQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSN 1762
Query: 290 SALSLWKWKYEELKESKPKNVKE----FDILLGQHNDEMQELSGNIKEESKSQNSKDRVI 345
AL K +E ++KE D L G +++ +LS N++++ ++ N+K
Sbjct: 1763 DALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLS-NMQKDLENSNAK---- 1817
Query: 346 CELRAELERLQA-ENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSAN- 403
L+ +++ L+A E+ K+++ E +K+ E E +LK Q+K+ L K + N
Sbjct: 1818 --LQEKIQELKANEHQLITLKKDVNETQKKVSEME--QLKKQIKDQSLTLSKLEIENLNL 1873
Query: 404 SQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRL 463
+Q + ++ K ++ L KL R + T A + Q E +K R+
Sbjct: 1874 AQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQE--LKTARM 1931
Query: 464 RVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRHLQ 511
+E K+ +++ +++ + QI +Q+ LD+ K + L+ +++ LQ
Sbjct: 1932 LSKEHKETVDKLREKISEKTIQISDIQKDLDKSK---DELQKKIQELQ 1976
Score = 59.3 bits (142), Expect = 8e-09
Identities = 84/417 (20%), Positives = 185/417 (44%), Gaps = 30/417 (7%)
Query: 116 AREEGRQLRI--KLEMAMKELSTL-KKKQSLPPQKEALEANVTQDLK------LPGFVEE 166
AR E +LR+ K + + +E+ +L K++ +L KEALE Q LK L E
Sbjct: 1324 ARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQ-LKEHIRETLAKIQES 1382
Query: 167 SCEHTDQFQLSSQMHESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDL 226
+ + + +E+ + QF K+ + + I+ L LS+ ++ + D ++
Sbjct: 1383 QSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLR---IEIEMLGLSKRLQESHD--EM 1437
Query: 227 FNNGGSGNGETKTGLRLKAINLPLENEVTEISALQVHLDEFQKI----LWKEREMRTALE 282
+ + + L++ + L+ + EI A + +E K+ L ++ E L
Sbjct: 1438 KSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELR 1497
Query: 283 KEIERLESALSLWKWKYEELKESKPKNVKEFDILLGQHN----DEMQELSGNIKEESKSQ 338
+ E+ +S + + E + + ++E Q N E+QE +K+ + +
Sbjct: 1498 VNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHR 1557
Query: 339 NSKDRVICELRAELERLQAENTSEWDKREILEREKQGLERENRRLKI---QVKEMEELLD 395
+KD + + +++ L ++ +I+ +EK+ ++R L+I Q+KE + +
Sbjct: 1558 KAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIV 1617
Query: 396 KKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNE 455
K + S + KM+ ++ E +++ ++H + Q + N+ + N R+ Q
Sbjct: 1618 AKMKESQEKEYQFLKMTAVN--ETQEKMCEIEHLKEQFETQ-KLNLENIETENIRLTQIL 1674
Query: 456 AEVKKLRLRVEELKQGLNQKEDELDDSLNQIRK-LQRSLDEEKERNENLETELRHLQ 511
E + V + + L E+ L +Q+++ L+ ++ + E+ E L+ HL+
Sbjct: 1675 HENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLK 1731
Score = 49.7 bits (117), Expect = 6e-06
Identities = 96/477 (20%), Positives = 196/477 (41%), Gaps = 57/477 (11%)
Query: 69 ICEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLE 128
I E+L+ + LEEVK + + + + S + N + QLR LE
Sbjct: 913 ITEKLQ-QTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALE 971
Query: 129 MAMKELSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIREYL 188
S + ++++ K + V+++L + E + E D+FQ + ++
Sbjct: 972 ------SLKQHQETINTLKSKISEEVSRNLHME---ENTGETKDEFQQKMVGIDKKQDLE 1022
Query: 189 VKRQFSTKEDTNNKE----QGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLK 244
K + D + E Q + ++ E++ L+ V + + KT L+ +
Sbjct: 1023 AKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVI------AEKEQLKTDLK-E 1075
Query: 245 AINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEI----ERLESALSLWKWKYE 300
I + +EN+ E+ L L + Q+I+ +E+ E E+ +RL K K +
Sbjct: 1076 NIEMTIENQ-EELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQ 1134
Query: 301 ELKESKPK--NVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAE 358
+L+E + + NV+E + + +E++ L +K + + + EL +L E
Sbjct: 1135 QLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEE 1194
Query: 359 NTSEWDKREILEREKQGLERENRRLKIQVKEMEEL-LDKKNRLSANSQSPDFKMSQID-- 415
S +R++L+ ++ E E L+ ++E+E L K L ID
Sbjct: 1195 VKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDEL 1254
Query: 416 ---LQEKNQELLN---LQHAYYKLNRQYQA---------NIAELTHANNRVDQNEAEVKK 460
+ EK +++N L+ ++ KL + N+ E++ +++ E ++
Sbjct: 1255 RRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQ 1314
Query: 461 ---------LRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELR 508
R+ +E L+ LN+K E + + + K + +L KE E +L+
Sbjct: 1315 STTKDSTTLARIEMERLR--LNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLK 1369
Score = 48.1 bits (113), Expect = 2e-05
Identities = 74/383 (19%), Positives = 153/383 (39%), Gaps = 61/383 (15%)
Query: 123 LRIKLEMAMKELSTLKKK-QSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMH 181
L+ +EM ++ L+ L Q+E + +K G + +C+ +++
Sbjct: 1073 LKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRL------AEVE 1126
Query: 182 ESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGL 241
E ++E + Q ++ N +E+ EM+ ++ ++ N
Sbjct: 1127 EKLKEKSQQLQEKQQQLLNVQEE---------MSEMQKKINEIENLKN------------ 1165
Query: 242 RLKAINLPLENEVTEISALQVHLDEFQ---KILWKEREMRTALEKEIERLESALSLWKWK 298
LK L LE+ TE L L+E K + KER++ L+K E L + +
Sbjct: 1166 ELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIRE 1225
Query: 299 YEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAE 358
E + +K I L +H + + EL ++ E++ Q
Sbjct: 1226 IEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKT-------------------AQII 1266
Query: 359 NTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQE 418
NT + +K +E+ + E + L VKE+ E + N L ++ K S
Sbjct: 1267 NTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDS------ 1320
Query: 419 KNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDE 478
L ++ +LN ++Q + E+ D + + L ++ ++LK+ + + +
Sbjct: 1321 --TTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAK 1378
Query: 479 LDDSLNQIRKLQRSLDEEKERNE 501
+ +S + K ++SL+ +++ NE
Sbjct: 1379 IQESQS---KQEQSLNMKEKDNE 1398
Score = 47.4 bits (111), Expect = 3e-05
Identities = 97/473 (20%), Positives = 202/473 (42%), Gaps = 58/473 (12%)
Query: 69 ICEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLE 128
I EELR+ + +K + ++K S+ T +K S ++ + ++ + ++ +L+
Sbjct: 1772 IQEELRIAHMH-LKEQQETIDKLRGIVSEKT----DKLSNMQKDLENSNAKLQEKIQELK 1826
Query: 129 MAMKELSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIREYL 188
+L TLKK + +K + + + +K E + L+ ++HE++ E
Sbjct: 1827 ANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLE-IENLNLAQKLHENLEE-- 1883
Query: 189 VKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINL 248
+K +++ E+ + ++ +L E ++ DL E KT L +
Sbjct: 1884 MKSVMKERDNLRRVEETLKLERDQLKESLQET-KARDL-----EIQQELKTARMLSKEHK 1937
Query: 249 PLENEVTE-ISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELKESKP 307
+++ E IS + + + QK L K ++ L+K+I+ L+ L + +E
Sbjct: 1938 ETVDKLREKISEKTIQISDIQKDLDKSKD---ELQKKIQELQKK-ELQLLRVKEDVNMSH 1993
Query: 308 KNVKEFDILLGQHNDEMQELS------GNIKEESKSQNSKD--RVICELRAELERLQAEN 359
K + E + L Q E Q LS N + K S + R++ + R EL R++
Sbjct: 1994 KKINEMEQLKKQF--EAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESL 2051
Query: 360 TSEWDK-----REILEREKQ-------------GLERENRRLKIQVKEMEELLDKKNRLS 401
E D+ RE++ R++Q G + L+ + ++ELL + + +
Sbjct: 2052 KMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMD 2111
Query: 402 ANSQSPDFKMSQIDLQ---EKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEV 458
+ + +DL+ E +EL A L +I +L AN R E
Sbjct: 2112 DHYEC--LNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSM---EF 2166
Query: 459 KKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRHLQ 511
++ +++ + + + ++E +S+N K + +E E+ + L +++HLQ
Sbjct: 2167 HRIMKKLKYVLSYVTKIKEEQHESIN---KFEMDFIDEVEKQKELLIKIQHLQ 2216
Score = 35.4 bits (80), Expect = 0.13
Identities = 41/175 (23%), Positives = 71/175 (40%), Gaps = 22/175 (12%)
Query: 127 LEMAMKELSTLKKKQSL--PPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESI 184
LE + + L+ K +L P KE +E +KL E ++ +F+ ++
Sbjct: 2432 LEKTKETIQVLQDKVALGAKPYKEEIE---DLKMKLVKIDLEKMKNAKEFEKEISATKAT 2488
Query: 185 REYLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLK 244
EY + +E+ +Q D+ +SE P L GGSG + L LK
Sbjct: 2489 VEYQKEVIRLLRENLRRSQQAQ--DTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILK 2546
Query: 245 AINLPLENEVT--------------EISALQVHLDEFQKILWKEREMRTALEKEI 285
+ ++ LE E++ E+ + HL K WKER ++ K++
Sbjct: 2547 SEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVK-TWKERTLKREAHKQV 2600
Score = 31.2 bits (69), Expect = 2.4
Identities = 62/285 (21%), Positives = 111/285 (38%), Gaps = 41/285 (14%)
Query: 121 RQLRIKLEMAMKELSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQF--QLSS 178
+ L+ K E K TLK + Q TQD K P + + T + +L +
Sbjct: 2333 KSLKEKNEKLFKNYQTLKTSLASGAQVNP----TTQDNKNPHVTSRATQLTTEKIRELEN 2388
Query: 179 QMHESIREYLVK--------RQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNG 230
+HE+ + K ++ D K Q V +S K E+ K + +
Sbjct: 2389 SLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVL------ 2442
Query: 231 GSGNGETKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLES 290
+ K L K P + E+ ++ V +D + KE EKEI ++
Sbjct: 2443 -----QDKVALGAK----PYKEEIEDLKMKLVKIDLEKMKNAKE------FEKEISATKA 2487
Query: 291 ALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKS---QNSKDRVICE 347
+ K L+E+ ++ + D + + + Q + + S QN+K +
Sbjct: 2488 TVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALI--- 2544
Query: 348 LRAELERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEE 392
L++E RL+ E + + E L ++K L N+ L +VK +E
Sbjct: 2545 LKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKE 2589
Score = 30.4 bits (67), Expect = 4.0
Identities = 42/216 (19%), Positives = 91/216 (42%), Gaps = 37/216 (17%)
Query: 331 IKEESKSQNSKDRVICELRA-----ELERLQAENTSEWDK-------------------R 366
I + S N+K R+IC + L LQ +T+++ K +
Sbjct: 291 ILQNSLGGNAKTRIICTITPVSFDETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRK 350
Query: 367 EILEREKQ--GLERENRRLKIQVKEMEELLDKKNRLSA-------NSQSPDFKMSQIDLQ 417
EI++ +KQ + E R ++ ++ +LL++K+ L N S + LQ
Sbjct: 351 EIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQ 410
Query: 418 E--KNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQK 475
+ K + + K+N+ +N A+ + + ++ LR E+ + + +
Sbjct: 411 QELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLR--EIDESVCSE 468
Query: 476 EDELDDSLNQIRKLQRSLDEEKERNENLETELRHLQ 511
D ++L+ + +++ + + EN+E+EL L+
Sbjct: 469 SDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLR 504
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 71.6 bits (174), Expect = 2e-12
Identities = 112/474 (23%), Positives = 195/474 (41%), Gaps = 87/474 (18%)
Query: 101 NWREKW-------SKVRAERNSAREEGRQLRIKLEMAMKELSTLK-----KKQSLPPQKE 148
+W+E++ S++R+E+ S E L LE+ E L+ K++ + +E
Sbjct: 1892 SWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEE 1951
Query: 149 ALEANVTQDLKLPGFVEESCEHTDQF-QLSSQMHESIREYLVKRQFSTKEDTNNKEQGVV 207
L ++ +L G ++ + T QLS +M E +E Q
Sbjct: 1952 ELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQEL-------------ESHQSEC 1998
Query: 208 IDSLKLSE-EMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLENEVTEISALQVHLDE 266
+ ++++E E+K + + ++ S + KT L+ K + LE + +S + L+
Sbjct: 1999 LHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQS--LEKDSQALSLTKCELEN 2056
Query: 267 FQKILWKEREMRTALEKEIERLESALSLWKWKYEELKESKPKNVK-----EFDILLGQHN 321
L KE+E+ L KE E L++ LS + YE+L SK EF + L
Sbjct: 2057 QIAQLNKEKEL---LVKESESLQARLS--ESDYEKLNVSKALEAALVEKGEFALRLSSTQ 2111
Query: 322 DEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWDKREILEREKQG------ 375
+E+ +L I++ + ++ + +L+ + EN S DK E LERE Q
Sbjct: 2112 EEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQE 2171
Query: 376 ---LERENRR-----LKIQVKEMEE-----------LLDKKNRLSANSQSPDFKMSQID- 415
L+ EN + LK Q++EM L +K L+ Q ++S++D
Sbjct: 2172 LVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDK 2231
Query: 416 --------LQEKNQELLNLQHAYYKLNRQYQANIAELTHA--------------NNRVDQ 453
L+EK Q + ++ Q + EL A +D
Sbjct: 2232 LLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDP 2291
Query: 454 NEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETEL 507
E +LR +E+L+ L E + L Q+++ + D K R ENLE EL
Sbjct: 2292 PIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLEREL 2345
Score = 66.6 bits (161), Expect = 5e-11
Identities = 93/454 (20%), Positives = 190/454 (41%), Gaps = 46/454 (10%)
Query: 77 ELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAMKELST 136
E E ++++ +E ++ + + E+ + +R + E R L L+ E+ T
Sbjct: 636 EKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVET 695
Query: 137 -------LKKKQSLPPQK--EALEANVTQDLKLPGFVEE--------SCEHTDQFQLSSQ 179
L++K QK + +E + +L G VE+ S E D+ +
Sbjct: 696 QKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQD 755
Query: 180 MH---ESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGE 236
+H ES+R+ L + S + +++ + D N+ G GS E
Sbjct: 756 LHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQ-----GSMPSE 810
Query: 237 TKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWK 296
++ RL+A P + + LQ +D + L +++M + L+K+ E L
Sbjct: 811 -RSECRLEADQSPKNSAI-----LQNRVDSLEFSLESQKQMNSDLQKQCEELV------- 857
Query: 297 WKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQ 356
++K +N+ + + + H + E S I + + ++ V+ E + LE +
Sbjct: 858 ----QIKGEIEENLMKAEQM---HQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKE 910
Query: 357 AENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDL 416
E DK E + E Q L++ N L+ +KE++ LL + L S +++ ++
Sbjct: 911 KELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQ-LLSETLSLEKKEMSSIISLNKREI 969
Query: 417 QEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKE 476
+E QE L+ LN++ I + N +D+ E + +L + ++ K L Q+
Sbjct: 970 EELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRC 1029
Query: 477 DELDDSLNQIRKLQRSLDEEKERNENLETELRHL 510
+E ++ + + ++ E+ + E L E L
Sbjct: 1030 EETGNAYEDLSQKYKAAQEKNSKLECLLNECTSL 1063
Score = 59.3 bits (142), Expect = 8e-09
Identities = 90/419 (21%), Positives = 170/419 (40%), Gaps = 52/419 (12%)
Query: 105 KWSKVRAERNSAREEGRQLRIKLEMAMKELSTLKKKQSLPPQKEALEANVTQDLKLPGFV 164
K+ ++ + N EE R +LE +K L K Q+LP Q ++ +
Sbjct: 163 KYEDLKEKYNKEVEE----RKRLEAEVKALQAKKASQTLP-QATMNHRDIARHQASSSVF 217
Query: 165 EESCEHTDQFQLSSQMHESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGV 224
E T S+ IR FS +++ + I + N
Sbjct: 218 SWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSP 277
Query: 225 DLFNNGGSGNGETKTGLRLKAINLPLENEVTEISA-LQVHLDEFQKILWKEREMRTALEK 283
L + +LKA N L N++ E+ LQ H E + + K +E++ LEK
Sbjct: 278 HLLD-------------QLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEK 324
Query: 284 -EIERLESALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKD 342
++E +E L K + E ++ + ++D ++ Q+L ++ S + + +
Sbjct: 325 AKVELIEKEKVLNKCRDELVRTTA-----QYDQASTKYTALEQKLKKLTEDLSCQRQNAE 379
Query: 343 RVICELRAELERLQAENTSEWDKREILEREKQGLERENRRLKIQV-KEMEELLDKKNRLS 401
C L +++ + E E +++ R Q L++E ++K ++ +E+++ + N L
Sbjct: 380 SARCSLEQKIKEKEKEFQEELSRQQ---RSFQTLDQECIQMKARLTQELQQAKNMHNVLQ 436
Query: 402 ANSQSPDFKMSQID--LQEKNQELLNLQHAYYKLN---RQYQANIAELTHANNRV----D 452
A Q++ L+E Q+L + A+ + + ++ E+ NN + +
Sbjct: 437 AELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSE 496
Query: 453 QNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRHLQ 511
Q EV L ++ +KQ LNQ Q +E K +N + ET LR LQ
Sbjct: 497 QKAREVCHLEAELKNIKQCLNQS--------------QNFAEEMKAKNTSQETMLRDLQ 541
Score = 55.5 bits (132), Expect = 1e-07
Identities = 88/417 (21%), Positives = 175/417 (41%), Gaps = 79/417 (18%)
Query: 105 KWSKVRAERNSAREEGRQLR-IKLEMAMKELSTLKKKQSLPPQKEALEA---NVTQDLKL 160
K S+V E +E+ +LR + +E+ K K SL E L++ N+ +L+L
Sbjct: 2540 KLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELEL 2599
Query: 161 P-----GFVEESCEHT-DQFQLSSQMHESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLS 214
FVE+ + T + +L +MHE + ++ +E+ + ++ + + L
Sbjct: 2600 TKMDKMSFVEKVNKMTAKETELQREMHE-----MAQKTAELQEELSGEKNRLAGELQLLL 2654
Query: 215 EEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWKE 274
EE+K + D + N E K K+++ +++V + ++ + E+Q L +
Sbjct: 2655 EEIKSSKDQLKELT---LENSELK-----KSLDCMHKDQVEKEGKVREEIAEYQLRLHEA 2706
Query: 275 REMRTALEKEIER-LESALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKE 333
+ AL + + E + ++ K +E E D+L
Sbjct: 2707 EKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLL----------------- 2749
Query: 334 ESKSQNSKDRVICELRAELERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEEL 393
++SK+ + L+A + L+ ++ D + + + K+ ER ++K+ +K ++L
Sbjct: 2750 ----KSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQL 2805
Query: 394 LDKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQ 453
++K L +EL LQ A K T + +VD+
Sbjct: 2806 EEEKEILQ-------------------KELSQLQAAQEKQKTG--------TVMDTKVDE 2838
Query: 454 NEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRHL 510
E+K ELK+ L +K E D+ L++ L S ++ ++ E LET++ HL
Sbjct: 2839 LTTEIK-------ELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHL 2888
Score = 50.1 bits (118), Expect = 5e-06
Identities = 85/441 (19%), Positives = 175/441 (39%), Gaps = 54/441 (12%)
Query: 108 KVRAERNSAREEGRQLRIKLEMAMKELS-TLKKKQSLPPQKEALEANVTQDLK-LPGFVE 165
+++A+ R + +L ++L+ KE+ + K Q L Q E + + + K L +
Sbjct: 282 QLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRD 341
Query: 166 ESCEHTDQFQLSSQMHESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVD 225
E T Q+ +S + ++ + L K N E K+ E+ K + +
Sbjct: 342 ELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQE--E 399
Query: 226 LFNNGGSGNGETKTGLRLKA-INLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKE 284
L S + +++KA + L+ + LQ LD+ + + +++
Sbjct: 400 LSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQK 459
Query: 285 IERLESALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQEL----------------S 328
+ R E A + K EL+ S + KE ++L + +E+ S
Sbjct: 460 LCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQS 519
Query: 329 GNIKEESKSQN-SKDRVICELRAELERLQAENTSEWDKREILEREKQG------------ 375
N EE K++N S++ ++ +L+ ++ + + T E K + + EKQ
Sbjct: 520 QNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREH 579
Query: 376 -----------LERENRRL----KIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKN 420
E+E++ L +++ KE EEL ++K S + ++Q++
Sbjct: 580 HIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQME----- 634
Query: 421 QELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELD 480
E NLQ L + + N RV E + + L + + L L+ K E++
Sbjct: 635 SEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVE 694
Query: 481 DSLNQIRKLQRSLDEEKERNE 501
+LQ+ + ++++
Sbjct: 695 TQKLAYMELQQKAEFSDQKHQ 715
Score = 48.9 bits (115), Expect = 1e-05
Identities = 104/493 (21%), Positives = 192/493 (38%), Gaps = 98/493 (19%)
Query: 71 EELRLRELEEVKARAAQMEKTMRWWSD----CTANW----------REKWSKVRAERNSA 116
+EL+L +LE+ K + EK + D TA + +K K+ + +
Sbjct: 316 QELQL-QLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQ 374
Query: 117 REEGRQLRIKLEMAMKE--------LSTLKKK-QSLPPQKEALEANVTQDLK-------- 159
R+ R LE +KE LS ++ Q+L + ++A +TQ+L+
Sbjct: 375 RQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNV 434
Query: 160 ------------------LPGFVEESCEHTDQFQLSSQMHESIR---EYLVKRQFSTKED 198
L F ++ C FQ S +R E + K K
Sbjct: 435 LQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSH 494
Query: 199 TNNKEQGV-------------VIDSLKLSEEMKP-NLDGVDLFNNGGSGNGETKTGLRLK 244
+ K + V + S +EEMK N + + + + L L+
Sbjct: 495 SEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLE 554
Query: 245 AINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELKE 304
+ L + + + Q L + + + + + + EKE + L SAL L K +YEELKE
Sbjct: 555 KLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKE 614
Query: 305 SKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWD 364
K L E ++L ++ E ++ SK I L L+ Q ++ +
Sbjct: 615 EK--------TLFSCWKSENEKLLTQMESEKENLQSK---INHLETCLKTQQIKSHEYNE 663
Query: 365 KREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEK----- 419
+ LE ++REN L ++++ + +LD K+ + +Q K++ ++LQ+K
Sbjct: 664 RVRTLE-----MDREN--LSVEIRNLHNVLDSKS-VEVETQ----KLAYMELQQKAEFSD 711
Query: 420 ---NQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKE 476
+E+ N+ +L Q + +L +N + + + L E L+ L K+
Sbjct: 712 QKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKD 771
Query: 477 DELDDSLNQIRKL 489
L + + R L
Sbjct: 772 ASLVTNEDHQRSL 784
Score = 46.6 bits (109), Expect = 5e-05
Identities = 61/284 (21%), Positives = 127/284 (44%), Gaps = 30/284 (10%)
Query: 250 LENEVTEISALQVHLDEFQKILWKE-----REMRTALEKEIERLESALSLWKWKYEELKE 304
L NE+ E+ + ++HL E Q + E ++ L+KE L L + ++EL +
Sbjct: 1800 LLNEMKELDS-KLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQ 1858
Query: 305 S-KPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEW 363
+ D+ + +++ N+ + + S K+R + ++ EL R+++E S
Sbjct: 1859 RVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSW--KERFL-DVENELSRIRSEKASIE 1915
Query: 364 DKR-------EILEREKQGLERENRRLKIQVKEMEELLD----KKNRLSANSQSPDFKMS 412
+ E+++ EK LE++N + + +EE L ++N+L + K +
Sbjct: 1916 HEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTT 1975
Query: 413 QID-----LQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEE 467
+D ++EK QEL + Q + +A + E T + + +E+ K + ++E
Sbjct: 1976 ALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQE 2035
Query: 468 LKQGLNQKEDELD----DSLNQIRKLQRSLDEEKERNENLETEL 507
Q L + L + NQI +L + + + +E+L+ L
Sbjct: 2036 KLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARL 2079
Score = 45.4 bits (106), Expect = 1e-04
Identities = 85/400 (21%), Positives = 168/400 (42%), Gaps = 73/400 (18%)
Query: 139 KKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIREYLVKRQFSTKED 198
K+Q+L Q E LE Q L+ G E + L S ++ I+E +Q K+D
Sbjct: 2467 KEQNLSSQVECLELEKAQLLQ--GLDEAK---NNYIVLQSSVNGLIQEVEDGKQKLEKKD 2521
Query: 199 TNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLENEVTEIS 258
+E + + ++ E++ L V+ G + L L+ + + LE ++ +
Sbjct: 2522 ---EEISRLKNQIQDQEQLVSKLSQVE-----GEHQLWKEQNLELRNLTVELEQKIQVLQ 2573
Query: 259 ALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKW-KYEELKESKPKNVKEFDILL 317
+ L + ++L + + LE+ L L K K +++ KE ++
Sbjct: 2574 SKNASLQDTLEVL----------QSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQR 2623
Query: 318 GQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWDKREILEREKQGLE 377
H EM + + ++EE + K+R+ EL+ LE +++ K ++ E L
Sbjct: 2624 EMH--EMAQKTAELQEELSGE--KNRLAGELQLLLEEIKSS------KDQLKE-----LT 2668
Query: 378 RENRRLKIQVKEM-EELLDKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQ 436
EN LK + M ++ ++K+ ++ + ++++ + ++K+Q LL N+Q
Sbjct: 2669 LENSELKKSLDCMHKDQVEKEGKV--REEIAEYQLRLHEAEKKHQALL------LDTNKQ 2720
Query: 437 YQANIA----ELTHANNRVDQNEAEVKKLRLRVEELKQGL-------------------- 472
Y+ I +LT + + E+ L+ EEL L
Sbjct: 2721 YEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKY 2780
Query: 473 -NQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRHLQ 511
NQ + E + + +++ L +S + +E E L+ EL LQ
Sbjct: 2781 VNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQ 2820
Score = 39.3 bits (90), Expect = 0.009
Identities = 49/233 (21%), Positives = 90/233 (38%), Gaps = 64/233 (27%)
Query: 297 WKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQ 356
W EE KE P + ++QEL G + + K + + + +L+ L+
Sbjct: 3 WALEEWKEGLPTRALQ----------KIQELEGQLDKLKKEKQQR-------QFQLDSLE 45
Query: 357 AENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDL 416
A + K E + E L+REN+RL ++ E L K ++S Q K SQ++
Sbjct: 46 AALQKQKQKVENEKTEGTNLKRENQRL---MEICESLEKTKQKISHELQ---VKESQVNF 99
Query: 417 QEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKE 476
QE +L ++++ E E+K+ + +E +Q +
Sbjct: 100 QE-----------------------GQLNSGKKQIEKLEQELKRCKSELERSQQAAQSAD 136
Query: 477 DELDD------------------SLNQIRKLQRSLDEEKERNENLETELRHLQ 511
L+ S ++ L+ ++E E + LE E++ LQ
Sbjct: 137 VSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQ 189
Score = 37.4 bits (85), Expect = 0.033
Identities = 48/198 (24%), Positives = 81/198 (40%), Gaps = 17/198 (8%)
Query: 319 QHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWDKREILEREKQGLER 378
+ +M LS S +Q S D V C LQ EN + ++E +G+E
Sbjct: 1501 EQTGDMSLLSNLEGAVSANQCSVDEVFCS------SLQEENLT---RKETPSAPAKGVEE 1551
Query: 379 ENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQ 438
++ + +E+L +K ++ Q+ L + QEL L+ Y N Q+Q
Sbjct: 1552 LESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQL-LSSERQELDCLRKQYLSENEQWQ 1610
Query: 439 ANIAELT---HANNRVDQNEAEVKKLRLRVEELK-QGLNQKEDEL--DDSLNQIRKLQRS 492
+ +T + ++ + E L L V L+ QGL+ L D+ + I+ S
Sbjct: 1611 QKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNES 1670
Query: 493 LDEEKER-NENLETELRH 509
D KE +E E +H
Sbjct: 1671 CDISKEHTSETTERTPKH 1688
Score = 31.2 bits (69), Expect = 2.4
Identities = 34/152 (22%), Positives = 71/152 (46%), Gaps = 15/152 (9%)
Query: 278 RTALEKEIERLESALSLWKWKYEELKESKPKNVKEFDILLGQH---NDEMQELSGNIKEE 334
R +LEK E++ES + + +EL++ +E D L Q+ N++ Q+ ++ E
Sbjct: 1560 RQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLE 1619
Query: 335 SKSQNSKDRVICE---LRAELERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEME 391
+S+ + ++ E L E+ RLQ + ++ R G++ E+ IQ +
Sbjct: 1620 MESKLAAEKKQTEQLSLELEVARLQLQGL------DLSSRSLLGIDTED---AIQGRNES 1670
Query: 392 ELLDKKNRLSANSQSPDFKMSQIDLQEKNQEL 423
+ K++ ++P + QI ++ Q+L
Sbjct: 1671 CDISKEHTSETTERTPKHDVHQICDKDAQQDL 1702
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 70.9 bits (172), Expect = 3e-12
Identities = 102/469 (21%), Positives = 197/469 (42%), Gaps = 77/469 (16%)
Query: 73 LRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAMK 132
LR R +AR +EK + + K SK+ E+ ++E + K E A +
Sbjct: 570 LRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEE 629
Query: 133 ---ELSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIREYLV 189
EL L+K+ L QK+ +T + K+ +E+ E + + + +S +
Sbjct: 630 LENELHHLEKENELL-QKKITNLKITCE-KIEALEQENSELERENRKLKKTLDSFKNLTF 687
Query: 190 KRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLP 249
+ + KE++ E+ + E++ N++ + + +K L
Sbjct: 688 QLESLEKENSQLDEENL---------ELRRNVESLKCAS--------------MKMAQLQ 724
Query: 250 LENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLE---SALSLWKWKYEELKESK 306
LEN+ L+ ++ L K E+ A K+ ERLE L + + ++ E+
Sbjct: 725 LENK---------ELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENS 775
Query: 307 PKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWDKR 366
K +++ + L E Q L N++E S LE+L+ EN S +
Sbjct: 776 NKKIQQLESELQDLEMENQTLQKNLEELKISSK-----------RLEQLEKENKSLEQET 824
Query: 367 EILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQ------------I 414
LE++K+ LE+EN+RL+ Q + + L++ N N + + +S+
Sbjct: 825 SQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLK 884
Query: 415 DLQEKNQELLNLQHAYYK----LNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQ 470
+L+++N+EL+ K L + + NN +++ E++K+ L K+
Sbjct: 885 ELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLN----KE 940
Query: 471 GLNQKEDELDDSLNQIRK------LQRSLDEEKERNENLETELRHLQNW 513
L E DDS ++ + L++SL+ ++E+ LE L N+
Sbjct: 941 RLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNY 989
Score = 60.5 bits (145), Expect = 4e-09
Identities = 105/480 (21%), Positives = 201/480 (41%), Gaps = 52/480 (10%)
Query: 64 TNKWDICEELRLRELE--EVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGR 121
TN CE++ E E E++ +++KT+ D N + + E + EE
Sbjct: 649 TNLKITCEKIEALEQENSELERENRKLKKTL----DSFKNLTFQLESLEKENSQLDEENL 704
Query: 122 QLRIKLEMAMKELSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMH 181
+LR +E + +++K Q KE LE+ Q K ++ S + T++ ++S Q
Sbjct: 705 ELRRNVESL--KCASMKMAQLQLENKE-LESEKEQLKKGLELLKASFKKTERLEVSYQGL 761
Query: 182 ESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLSEE---MKPNLDGVDLFNNGGSGNGETK 238
+ + L K T E++N K Q + + L E ++ NL+ + + +K
Sbjct: 762 DIENQRLQK----TLENSNKKIQQLESELQDLEMENQTLQKNLEELKI---------SSK 808
Query: 239 TGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTA-----------LEKEIER 287
+L+ N LE E +++ + L++ K L ++ E++ LEKE +
Sbjct: 809 RLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKT 868
Query: 288 LESALSLWKWKYEELKESKPKN---VKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRV 344
L + ++K LKE + +N VK I + ++L + + N +++
Sbjct: 869 LSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKL 928
Query: 345 ICELRA---ELERLQAENTSEWDKR-EILERE-----KQGLERENRRLKIQVKEMEELLD 395
EL ERL + S D R ++LE + K+ LE + ++ +EE +
Sbjct: 929 THELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTN 988
Query: 396 KKNRLSANSQSPDFKMSQIDLQEKNQELLN----LQHAYYKLNRQYQANIAELTHANNRV 451
+L ++ + ++ + ++ + K R+ Q EL +R+
Sbjct: 989 YNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRL 1048
Query: 452 DQNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRHLQ 511
+ E L+ + LK L Q E + ++ QI LQR +E+N L+T+ LQ
Sbjct: 1049 IEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQ 1108
Score = 58.5 bits (140), Expect = 1e-08
Identities = 82/368 (22%), Positives = 162/368 (44%), Gaps = 38/368 (10%)
Query: 65 NKWDICEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLR 124
NKW+ + REL +VK R ++E+ + ++AE+ + + + +QL
Sbjct: 1028 NKWERESQETTRELLKVKDRLIEVERNN--------------ATLQAEKQALKTQLKQLE 1073
Query: 125 IKLEMAMKELSTLKKKQ-SLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQ---- 179
+ ++ L+++ SL Q L+ TQ+ KL VE S ++ L +Q
Sbjct: 1074 TQNNNLQAQILALQRQTVSLQEQNTTLQ---TQNAKLQ--VENSTLNSQSTSLMNQNAQL 1128
Query: 180 -MHESIREYLVKRQFSTKEDTNNKEQGVVID--SLKLSEEMKPNLDGVDLFNNGGSGNGE 236
+ +S E + +ED + ++ D L+L E + + + L + G+
Sbjct: 1129 LIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQAS-EYESLISKHGTLKSA 1187
Query: 237 TKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWK 296
K L+ + LE+ ++ + L++ +K+L E+E K E + +
Sbjct: 1188 HKN---LEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLC 1244
Query: 297 WKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQ 356
+ + L + + +KE ++L H + ++ L N K E Q + +L+ + ++L
Sbjct: 1245 GENDRLNHTYSQLLKETEVLQTDHKN-LKSLLNNSKLE---QTRLEAEFSKLKEQYQQLD 1300
Query: 357 AENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPD-FKMSQID 415
+T ++ E+L + K LE ENR L Q++ + +L + L N +S D F + Q
Sbjct: 1301 ITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTL--MLQNRTLLEQNMESKDLFHVEQRQ 1358
Query: 416 LQEKNQEL 423
+K EL
Sbjct: 1359 YIDKLNEL 1366
Score = 47.0 bits (110), Expect = 4e-05
Identities = 90/415 (21%), Positives = 167/415 (40%), Gaps = 69/415 (16%)
Query: 104 EKWSKVRAERNSAREEGRQLRIKLEMAMKELSTLKKKQSLPPQKEALEANVTQDLKLPGF 163
EK + + A + +QLR +EL T+KK Q++ E V + G
Sbjct: 974 EKIAALEARLEESTNYNQQLR-------QELKTVKKNYEALKQRQDEERMVQSSPPISG- 1025
Query: 164 VEESCEHTDQFQLSSQMHESIREYLVKRQFSTKEDTNNK----EQGVVIDSLKLSEEMKP 219
++++ SQ E+ RE L + + + NN E+ + LK E
Sbjct: 1026 ------EDNKWERESQ--ETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNN 1077
Query: 220 NLDGVDL-FNNGGSGNGETKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMR 278
NL L E T L+ + L +EN + + +++ ++L ++ +
Sbjct: 1078 NLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSL-MNQNAQLLIQQSSLE 1136
Query: 279 TALEKEIERLESALSLWKW---KYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEES 335
E I+ E SL+ +E+L+ + E++ L+ +H G +K
Sbjct: 1137 NENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKH--------GTLKSAH 1188
Query: 336 KSQNSKDRVICELRAELERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLD 395
K+ L+ E+ D+ L ++K LE + LK++ ++M LL+
Sbjct: 1189 KN-----------------LEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKM--LLE 1229
Query: 396 KKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNE 455
KN + + ++K L +N L H Y +L + + + + H N + N
Sbjct: 1230 NKNH---ETVAAEYKK----LCGENDRL---NHTYSQLLK--ETEVLQTDHKNLKSLLNN 1277
Query: 456 AEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRHL 510
+++++ RL E K L ++ +LD + KL + + NLE E RHL
Sbjct: 1278 SKLEQTRLEAEFSK--LKEQYQQLDITST---KLNNQCELLSQLKGNLEEENRHL 1327
Score = 46.6 bits (109), Expect = 5e-05
Identities = 84/413 (20%), Positives = 166/413 (40%), Gaps = 32/413 (7%)
Query: 117 REEGRQLRIKLEMAMKE----LSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTD 172
++E Q+ I+L+ +E LS + + + +AL + KL V E
Sbjct: 278 KQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLH 337
Query: 173 QFQLSSQMHESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGS 232
+ E ++E + TK ++ +G S KL E K NL ++
Sbjct: 338 DIEFYKARVEELKEDN-QVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDM-- 394
Query: 233 GNGETKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWK-EREMRTA---------LE 282
E + + K I +E +T A + +DE + W+ E+ RT+ L
Sbjct: 395 ---EMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLG 451
Query: 283 KEIERLESALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKD 342
E+ L S+ L K E +S K V+E + ++ +K E ++Q
Sbjct: 452 HEVNELTSSRLL---KLEMENQSLTKTVEELRTTVDSVEGNASKI---LKMEKENQRLSK 505
Query: 343 RV-ICELRAELERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLS 401
+V I E E+ +N K L +EK LE+ L+ + ++L+++N
Sbjct: 506 KVEILENEIVQEKQSLQNCQNLSKD--LMKEKAQLEKTIETLRENSERQIKILEQENEHL 563
Query: 402 ANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKL 461
+ S + SQI + + +++ ++ ++ + ++++ ++ + K+
Sbjct: 564 NQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEK 623
Query: 462 RLRVEELKQGLNQKEDE---LDDSLNQIRKLQRSLDEEKERNENLETELRHLQ 511
R EEL+ L+ E E L + ++ ++ ++ N LE E R L+
Sbjct: 624 GERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLK 676
Score = 44.7 bits (104), Expect = 2e-04
Identities = 59/260 (22%), Positives = 117/260 (45%), Gaps = 26/260 (10%)
Query: 273 KEREMRTALEKEIERLESALSLWKWKYEELKESKPKNVKEFDILLG--QHNDEMQELSGN 330
K R +R LE++ E+L + ELK + +N+ + DE+ L
Sbjct: 259 KIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREK 318
Query: 331 I----KEESKSQNSKDRV--ICELRAELERLQAENTSEWDKREILEREKQG--------- 375
K ES+ K+R+ I +A +E L+ +N + + +LE + +G
Sbjct: 319 AVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLH 378
Query: 376 -LERENRRLKIQVK--EMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYYK 432
LE+EN +LK ++ EME +D+K ++ +M+Q ++ E L+L +
Sbjct: 379 ELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQ---KQSMDESLHLGWELEQ 435
Query: 433 LNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRS 492
++R + + A + V NE +L L++E Q L + +EL +++ +
Sbjct: 436 ISRTSELSEAPQKSLGHEV--NELTSSRL-LKLEMENQSLTKTVEELRTTVDSVEGNASK 492
Query: 493 LDEEKERNENLETELRHLQN 512
+ + ++ N+ L ++ L+N
Sbjct: 493 ILKMEKENQRLSKKVEILEN 512
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 70.9 bits (172), Expect = 3e-12
Identities = 101/466 (21%), Positives = 196/466 (42%), Gaps = 72/466 (15%)
Query: 73 LRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAMK 132
LR R +AR +EK + + K SK+ E+ ++E + K E A +
Sbjct: 570 LRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEE 629
Query: 133 ---ELSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIREYLV 189
EL L+K+ L QK+ +T + K+ +E+ E + + + +S +
Sbjct: 630 LENELHHLEKENELL-QKKITNLKITCE-KIEALEQENSELERENRKLKKTLDSFKNLTF 687
Query: 190 KRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLP 249
+ + KE++ E+ + E++ N++ + + +K L
Sbjct: 688 QLESLEKENSQLDEENL---------ELRRNVESLKCAS--------------MKMAQLQ 724
Query: 250 LENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLE---SALSLWKWKYEELKESK 306
LEN+ L+ ++ L K E+ A K+ ERLE L + + ++ E+
Sbjct: 725 LENK---------ELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENS 775
Query: 307 PKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWDKR 366
K +++ + L E Q L N++E S LE+L+ EN S +
Sbjct: 776 NKKIQQLESELQDLEMENQTLQKNLEELKISSK-----------RLEQLEKENKSLEQET 824
Query: 367 EILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQ------------I 414
LE++K+ LE+EN+RL+ Q + + L++ N N + + +S+
Sbjct: 825 SQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLK 884
Query: 415 DLQEKNQELLNLQHAYYK----LNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEEL-- 468
+L+++N+EL+ K L + + NN +++ E++K+ L E L
Sbjct: 885 ELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLH 944
Query: 469 -KQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRHLQNW 513
+Q + + L+ L L++SL+ ++E+ LE L N+
Sbjct: 945 DEQSTDDRYKLLESKLES--TLKKSLEIKEEKIAALEARLEESTNY 988
Score = 63.2 bits (152), Expect = 6e-10
Identities = 104/479 (21%), Positives = 201/479 (41%), Gaps = 51/479 (10%)
Query: 64 TNKWDICEELRLRELE--EVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGR 121
TN CE++ E E E++ +++KT+ D N + + E + EE
Sbjct: 649 TNLKITCEKIEALEQENSELERENRKLKKTL----DSFKNLTFQLESLEKENSQLDEENL 704
Query: 122 QLRIKLEMAMKELSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMH 181
+LR +E + +++K Q KE LE+ Q K ++ S + T++ ++S Q
Sbjct: 705 ELRRNVESL--KCASMKMAQLQLENKE-LESEKEQLKKGLELLKASFKKTERLEVSYQGL 761
Query: 182 ESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLSEE---MKPNLDGVDLFNNGGSGNGETK 238
+ + L K T E++N K Q + + L E ++ NL+ + + +K
Sbjct: 762 DIENQRLQK----TLENSNKKIQQLESELQDLEMENQTLQKNLEELKI---------SSK 808
Query: 239 TGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTA-----------LEKEIER 287
+L+ N LE E +++ + L++ K L ++ E++ LEKE +
Sbjct: 809 RLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKT 868
Query: 288 LESALSLWKWKYEELKESKPKN---VKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRV 344
L + ++K LKE + +N VK I + ++L + + N +++
Sbjct: 869 LSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKL 928
Query: 345 ICELRA---ELERLQAENTSEWDKREILERE-----KQGLERENRRLKIQVKEMEELLDK 396
EL ERL + S D+ ++LE + K+ LE + ++ +EE +
Sbjct: 929 THELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNY 988
Query: 397 KNRLSANSQSPDFKMSQIDLQEKNQELLN----LQHAYYKLNRQYQANIAELTHANNRVD 452
+L ++ + ++ + ++ + K R+ Q EL +R+
Sbjct: 989 NQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLI 1048
Query: 453 QNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRHLQ 511
+ E L+ + LK L Q E + ++ QI LQR +E+N L+T+ LQ
Sbjct: 1049 EVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQ 1107
Score = 58.5 bits (140), Expect = 1e-08
Identities = 82/368 (22%), Positives = 162/368 (44%), Gaps = 38/368 (10%)
Query: 65 NKWDICEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLR 124
NKW+ + REL +VK R ++E+ + ++AE+ + + + +QL
Sbjct: 1027 NKWERESQETTRELLKVKDRLIEVERNN--------------ATLQAEKQALKTQLKQLE 1072
Query: 125 IKLEMAMKELSTLKKKQ-SLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQ---- 179
+ ++ L+++ SL Q L+ TQ+ KL VE S ++ L +Q
Sbjct: 1073 TQNNNLQAQILALQRQTVSLQEQNTTLQ---TQNAKLQ--VENSTLNSQSTSLMNQNAQL 1127
Query: 180 -MHESIREYLVKRQFSTKEDTNNKEQGVVID--SLKLSEEMKPNLDGVDLFNNGGSGNGE 236
+ +S E + +ED + ++ D L+L E + + + L + G+
Sbjct: 1128 LIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQAS-EYESLISKHGTLKSA 1186
Query: 237 TKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWK 296
K L+ + LE+ ++ + L++ +K+L E+E K E + +
Sbjct: 1187 HKN---LEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLC 1243
Query: 297 WKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQ 356
+ + L + + +KE ++L H + ++ L N K E Q + +L+ + ++L
Sbjct: 1244 GENDRLNHTYSQLLKETEVLQTDHKN-LKSLLNNSKLE---QTRLEAEFSKLKEQYQQLD 1299
Query: 357 AENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPD-FKMSQID 415
+T ++ E+L + K LE ENR L Q++ + +L + L N +S D F + Q
Sbjct: 1300 ITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTL--MLQNRTLLEQNMESKDLFHVEQRQ 1357
Query: 416 LQEKNQEL 423
+K EL
Sbjct: 1358 YIDKLNEL 1365
Score = 47.4 bits (111), Expect = 3e-05
Identities = 96/428 (22%), Positives = 168/428 (39%), Gaps = 70/428 (16%)
Query: 112 ERNSAREEGRQLRIKLEMAMKELSTLKKKQSLPPQK-EALEANVTQDLKLPGFVEESCEH 170
ER E+ R KL + K STLKK + +K ALEA + EES +
Sbjct: 940 ERLLHDEQSTDDRYKL-LESKLESTLKKSLEIKEEKIAALEARL----------EESTNY 988
Query: 171 TDQFQLSSQMHESIREYLVKRQFSTK----------EDTN--NKEQGVVIDSLKLSEEMK 218
Q + + + E L +RQ + ED + Q + LK+ + +
Sbjct: 989 NQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRL- 1047
Query: 219 PNLDGVDLFNNGGSGNGETKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMR 278
+++ N + E + A+ L+ T+ + LQ + Q+ +E
Sbjct: 1048 -----IEVERNNATLQAEKQ------ALKTQLKQLETQNNNLQAQILALQRQTVSLQEQN 1096
Query: 279 TALEKEIERLESALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQ 338
T L+ + +L+ S + L + LL Q + E IKE +
Sbjct: 1097 TTLQTQNAKLQVENSTLNSQSTSLMNQNAQ-------LLIQQSSLENENESVIKEREDLK 1149
Query: 339 NSKDRVICELRAELERLQAENTSEWD----KREILEREKQGLERENRRLKIQVKEMEELL 394
+ D +I + +LE L SE++ K L+ + LE E+R L+ +LL
Sbjct: 1150 SLYDSLIKD-HEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLE---DRYNQLL 1205
Query: 395 DKKNRLSANSQSPDFKMSQIDLQEKNQELL------------NLQHAYYKLNRQYQANIA 442
+K +L + + ++ L+ KN E + L H Y +L + + +
Sbjct: 1206 KQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLK--ETEVL 1263
Query: 443 ELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNEN 502
+ H N + N +++++ RL E K L ++ +LD + KL + + N
Sbjct: 1264 QTDHKNLKSLLNNSKLEQTRLEAEFSK--LKEQYQQLDITST---KLNNQCELLSQLKGN 1318
Query: 503 LETELRHL 510
LE E RHL
Sbjct: 1319 LEEENRHL 1326
Score = 46.6 bits (109), Expect = 5e-05
Identities = 84/413 (20%), Positives = 166/413 (40%), Gaps = 32/413 (7%)
Query: 117 REEGRQLRIKLEMAMKE----LSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTD 172
++E Q+ I+L+ +E LS + + + +AL + KL V E
Sbjct: 278 KQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLH 337
Query: 173 QFQLSSQMHESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGS 232
+ E ++E + TK ++ +G S KL E K NL ++
Sbjct: 338 DIEFYKARVEELKEDN-QVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDM-- 394
Query: 233 GNGETKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWK-EREMRTA---------LE 282
E + + K I +E +T A + +DE + W+ E+ RT+ L
Sbjct: 395 ---EMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLG 451
Query: 283 KEIERLESALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKD 342
E+ L S+ L K E +S K V+E + ++ +K E ++Q
Sbjct: 452 HEVNELTSSRLL---KLEMENQSLTKTVEELRTTVDSVEGNASKI---LKMEKENQRLSK 505
Query: 343 RV-ICELRAELERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLS 401
+V I E E+ +N K L +EK LE+ L+ + ++L+++N
Sbjct: 506 KVEILENEIVQEKQSLQNCQNLSKD--LMKEKAQLEKTIETLRENSERQIKILEQENEHL 563
Query: 402 ANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKL 461
+ S + SQI + + +++ ++ ++ + ++++ ++ + K+
Sbjct: 564 NQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEK 623
Query: 462 RLRVEELKQGLNQKEDE---LDDSLNQIRKLQRSLDEEKERNENLETELRHLQ 511
R EEL+ L+ E E L + ++ ++ ++ N LE E R L+
Sbjct: 624 GERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLK 676
Score = 44.7 bits (104), Expect = 2e-04
Identities = 59/260 (22%), Positives = 117/260 (45%), Gaps = 26/260 (10%)
Query: 273 KEREMRTALEKEIERLESALSLWKWKYEELKESKPKNVKEFDILLG--QHNDEMQELSGN 330
K R +R LE++ E+L + ELK + +N+ + DE+ L
Sbjct: 259 KIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREK 318
Query: 331 I----KEESKSQNSKDRV--ICELRAELERLQAENTSEWDKREILEREKQG--------- 375
K ES+ K+R+ I +A +E L+ +N + + +LE + +G
Sbjct: 319 AVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLH 378
Query: 376 -LERENRRLKIQVK--EMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYYK 432
LE+EN +LK ++ EME +D+K ++ +M+Q ++ E L+L +
Sbjct: 379 ELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQ---KQSMDESLHLGWELEQ 435
Query: 433 LNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRS 492
++R + + A + V NE +L L++E Q L + +EL +++ +
Sbjct: 436 ISRTSELSEAPQKSLGHEV--NELTSSRL-LKLEMENQSLTKTVEELRTTVDSVEGNASK 492
Query: 493 LDEEKERNENLETELRHLQN 512
+ + ++ N+ L ++ L+N
Sbjct: 493 ILKMEKENQRLSKKVEILEN 512
>gi|148762940 DVL-binding protein DAPLE [Homo sapiens]
Length = 2028
Score = 69.7 bits (169), Expect = 6e-12
Identities = 104/484 (21%), Positives = 196/484 (40%), Gaps = 67/484 (13%)
Query: 70 CEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSARE---EGRQLRIK 126
C+E +L +++ KAR ++ + + A E+ + RA + E E QL+ K
Sbjct: 335 CKE-KLHDVDFYKARMEELREDNIILIETKAMLEEQLTAARARGDKVHELEKENLQLKSK 393
Query: 127 LEMAMKELSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCE---HTDQFQLSSQMHES 183
L + T KK+ +E LE N+ ++ + ES +Q ++ + ++
Sbjct: 394 LHDLELDRDTDKKRI-----EELLEENMVLEIAQKQSMNESAHLGWELEQLSKNADLSDA 448
Query: 184 IREYLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRL 243
R+ V F E +++ + ++ L ++ D + G GE
Sbjct: 449 SRKSFV---FELNECASSRILKLEKENQSLQSTIQGLRDASLVLEESGLKCGE------- 498
Query: 244 KAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELK 303
LE E ++S +++ Q L +E++ LE E L + E LK
Sbjct: 499 ------LEKENHQLSK---KIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDMETLK 549
Query: 304 ESKPKNVKEFDILLGQHNDEMQEL--------SGNIKEESKSQNSKDRVICELRAELERL 355
K + +K+ + N M L +K+ K + + + E +L +L
Sbjct: 550 ADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEANGKLSQL 609
Query: 356 QAENTS----------EWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQ 405
+ E + ++ E LERE Q L+ EN RL +V +E +K L SQ
Sbjct: 610 EFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGRLARKVTSLETATEKVEALEHESQ 669
Query: 406 -----SPDFKMSQIDLQEKNQELLNLQHAYYKL---NRQYQANIAELTHANNRVDQNEAE 457
+ + S LQ + +L L+ +L N + + + + + ++ Q E E
Sbjct: 670 GLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVETMRFTSTKLAQMERE 729
Query: 458 VKKLRLRVEELK------QGLNQKEDELDDSLNQIR----KLQRSLDEEKERNENLETEL 507
++L EEL+ + L +K + L+ S + +LQ+SL+ + + LE+EL
Sbjct: 730 NQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSHKTQTLESEL 789
Query: 508 RHLQ 511
L+
Sbjct: 790 GELE 793
Score = 50.4 bits (119), Expect = 4e-06
Identities = 59/277 (21%), Positives = 120/277 (43%), Gaps = 16/277 (5%)
Query: 239 TGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWK 298
T RL+ + LE++ ++ + +D+ L K ++ L + + ++ +
Sbjct: 259 TKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARSARA----YRDE 314
Query: 299 YEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAE 358
+ L+E K V+ ++ L + +++ ++ K + + ++ E +A LE
Sbjct: 315 LDSLRE-KANRVERLELELTRCKEKLHDVDF-YKARMEELREDNIILIETKAMLEEQLTA 372
Query: 359 NTSEWDKREILEREKQGLERENRRLKIQ----VKEMEELLDKKNRLS-ANSQSPDFKMS- 412
+ DK LE+E L+ + L++ K +EELL++ L A QS +
Sbjct: 373 ARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIEELLEENMVLEIAQKQSMNESAHL 432
Query: 413 --QIDLQEKNQELLNLQHA--YYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEEL 468
+++ KN +L + ++LN + I +L N + ++ L +EE
Sbjct: 433 GWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASLVLEES 492
Query: 469 KQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLET 505
+ E E +I KLQ L+ EK+ N++LET
Sbjct: 493 GLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLET 529
Score = 50.1 bits (118), Expect = 5e-06
Identities = 78/419 (18%), Positives = 171/419 (40%), Gaps = 62/419 (14%)
Query: 104 EKWSKVRAERNSAREEGRQLRIKLEMAMKELSTLKKKQS---------LPPQKEALEANV 154
EK + A+ RQL +L+M KE TL++ Q P + ++
Sbjct: 977 EKIVLLEAQMEEKASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAASHQ 1036
Query: 155 TQDLKLPGFVEESCEHTDQFQLSSQMHESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLS 214
++ PG E + E + ++ + ++Q ++ + + Q V S L+
Sbjct: 1037 GKEAWGPGHKEATMELLRVKDRAIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQILT 1096
Query: 215 EEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWKE 274
L F + +T+T +L+ N L ++ ++A L E
Sbjct: 1097 ------LQKQSAFLQEHNTTLQTQTA-KLQVENSTLSSQSAALTAQYTLLQNHHTAKETE 1149
Query: 275 REMRTALEKEIERLESALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEE 334
E +L+++ E+L +A +E L + E++ L+ QH+ ++ L N++ E
Sbjct: 1150 NE---SLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSC-LKTLHRNLELE 1205
Query: 335 SKSQNSKDRVICELRAELERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEELL 394
K + + + +AELE ++ ++L E++ L++E R + + E + L
Sbjct: 1206 HKELGERHGDMLKRKAELE----------EREKVLTTEREALQQEQRTNALAMGENQRLR 1255
Query: 395 DKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQN 454
+ +R++ +++L +Y+ A ++
Sbjct: 1256 GELDRVN--------------------------FLHHQLKGEYEELHAHTKELKTSLNNA 1289
Query: 455 EAEVKKLRLRVEELK---QGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRHL 510
+ E+ + + R +ELK Q ++ +LD+ + +L+ +L+EE N +L ++++ L
Sbjct: 1290 QLELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRLKGNLEEE---NHHLLSQIQLL 1345
Score = 45.4 bits (106), Expect = 1e-04
Identities = 100/480 (20%), Positives = 197/480 (41%), Gaps = 91/480 (18%)
Query: 75 LRELEEV--KARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAMK 132
LRE +V +AR +EK + K S++ E+ + Q + K E A K
Sbjct: 573 LRERSQVSSEARMKDVEKENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEK 632
Query: 133 ---ELSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQ-FQLSSQMHESIREYL 188
EL L+++ +K T+ + E+ EH Q QL ++
Sbjct: 633 LERELQRLQEENGRLARKVTSLETATEKV-------EALEHESQGLQLENRT-------- 677
Query: 189 VKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINL 248
+++ T ++ + + +G+ D+ +L E NL+ L ET K +
Sbjct: 678 LRKSLDTLQNVSLQLEGLERDNKQLDAE---NLELRRLV--------ETMRFTSTKLAQM 726
Query: 249 PLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLE---SALSLWKWKYEELKES 305
EN+ L+ ++ L K ++ AL K+ ERLE ++S + ++ ES
Sbjct: 727 ERENQ---------QLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLES 777
Query: 306 KPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWDK 365
+ + LG+ E Q L +++ + A+LE + + + +
Sbjct: 778 SSHKTQTLESELGELEAERQALRRDLE-----------ALRLANAQLEGAEKDRKALEQE 826
Query: 366 REILEREKQGLERENRRLKIQVKEMEELLD----KKNRLSANSQSPDFKMSQIDLQEKNQ 421
LE++K+ LE+E +RL QV+ + +LD K + + S++ D ++++ ++
Sbjct: 827 VAQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELAR--CRDAAG 884
Query: 422 ELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQ-----GLN--- 473
+L L+ L +Q + LT + + + ++L +++L Q GLN
Sbjct: 885 KLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNREL 944
Query: 474 --QKEDELDDSLNQIRK--------------------LQRSLDEEKERNENLETELRHLQ 511
Q++D D+ +I + L+ ++E+ N LE+EL+ L+
Sbjct: 945 LLQEDDSGSDTKYKILEGRNESALKTTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLK 1004
Score = 41.6 bits (96), Expect = 0.002
Identities = 38/165 (23%), Positives = 79/165 (47%), Gaps = 17/165 (10%)
Query: 236 ETKTGLRLKAINLPLENEVTEISALQVHLD-EFQKILWKEREMRTALEKEIERLESALSL 294
E +T N L E+ ++ L L E++++ +E++T+L + L+
Sbjct: 1240 EQRTNALAMGENQRLRGELDRVNFLHHQLKGEYEELHAHTKELKTSLNNA----QLELNR 1295
Query: 295 WKWKYEELKESKPKNVKEFDILLGQ---HNDEMQELSGNIKEESKSQNSKDRVICELRAE 351
W+ +++ELKE + DI L + H + + L GN++EE+ S+ +++ +
Sbjct: 1296 WQARFDELKEQH----QTMDISLTKLDNHCELLSRLKGNLEEENHHLLSQIQLLSQQNQM 1351
Query: 352 LERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDK 396
L EN K + E +KQ +++ N + + K E+++D+
Sbjct: 1352 LLEQNMEN-----KEQYHEEQKQYIDKLNALRRHKEKLEEKIMDQ 1391
Score = 39.7 bits (91), Expect = 0.007
Identities = 82/367 (22%), Positives = 148/367 (40%), Gaps = 59/367 (16%)
Query: 52 HAAHNFCAHSYNTNKWDICEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRA 111
H A A W + EL VK RA ++E+ + ++A
Sbjct: 1026 HPAGKTAASHQGKEAWGPGHKEATMELLRVKDRAIELERNN--------------AALQA 1071
Query: 112 ERNSAREEGRQLRIKLEMAMKELSTLKKKQS-LPPQKEALEANVTQDLKLPGFVEESCEH 170
E+ +E+ + L + ++ TL+K+ + L L+ TQ KL VE S
Sbjct: 1072 EKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEHNTTLQ---TQTAKLQ--VENST-- 1124
Query: 171 TDQFQLSSQMHESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLS-EEMKPNLDGVDLFNN 229
LSSQ +Y + + T ++T N+ + L + E + + + + +
Sbjct: 1125 -----LSSQSAALTAQYTLLQNHHTAKETENESLQRQQEQLTAAYEALLQDHEHLGTLHE 1179
Query: 230 GGSGNGET--KTGLRLKAINLPLENEVTEISAL-------QVHLDEFQKILWKEREMRTA 280
S E + LK ++ LE E E+ + L+E +K+L ERE A
Sbjct: 1180 RQSAEYEALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAELEEREKVLTTERE---A 1236
Query: 281 LEKEIERLESALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNS 340
L++E + +AL++ + + + + L Q E +EL + KE S N+
Sbjct: 1237 LQQE--QRTNALAMGE------NQRLRGELDRVNFLHHQLKGEYEELHAHTKELKTSLNN 1288
Query: 341 KDRVICELRAELERLQAEN-------TSEWDKREILEREKQGLERENRRLKIQVKEMEEL 393
+ +A + L+ ++ T + E+L R K LE EN L Q+ +L
Sbjct: 1289 AQLELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRLKGNLEEENHHLLSQI----QL 1344
Query: 394 LDKKNRL 400
L ++N++
Sbjct: 1345 LSQQNQM 1351
>gi|16262452 cingulin [Homo sapiens]
Length = 1203
Score = 68.2 bits (165), Expect = 2e-11
Identities = 62/259 (23%), Positives = 118/259 (45%), Gaps = 17/259 (6%)
Query: 257 ISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELKESKPKNVKEFDIL 316
+S LQ + ++ L + R + E L L + + E K S+ ++ L
Sbjct: 908 LSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGL 967
Query: 317 LGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWDKREILEREKQGL 376
+++ L + EE + + R ++++L+ E E R+ LE +K L
Sbjct: 968 ----EEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISL 1023
Query: 377 ERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQ 436
ER+N+ LK ++ E +K S + ++ Q LQ + +E LQ KL R+
Sbjct: 1024 ERQNKDLKTRLASSEGF--QKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERK 1081
Query: 437 YQANIAELT----HANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRS 492
+ ++ H N++ DQ L LRV+ LK+ +++ E+E++ +K QR
Sbjct: 1082 VKELSIQIEDERQHVNDQKDQ-------LSLRVKALKRQVDEAEEEIERLDGLRKKAQRE 1134
Query: 493 LDEEKERNENLETELRHLQ 511
++E+ E NE L+ ++ L+
Sbjct: 1135 VEEQHEVNEQLQARIKSLE 1153
Score = 52.4 bits (124), Expect = 1e-06
Identities = 104/476 (21%), Positives = 201/476 (42%), Gaps = 60/476 (12%)
Query: 77 ELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAMKELST 136
E +++ A +++ + S+ T +W+ + K + + + ++E QLR++ E +EL
Sbjct: 546 ERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELG- 604
Query: 137 LKKKQSLPPQKEALEANVTQDLKLPGFVEE---SCEHTDQFQLSSQMHESI---REYLVK 190
+K + L + E A+ ++ +E + E + Q Q E R+ ++
Sbjct: 605 -EKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELE 663
Query: 191 RQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNG-----------GSGNGETKT 239
+Q + ++ + + +L+L + ++ + + G +T
Sbjct: 664 KQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVET 723
Query: 240 GLR--------LKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESA 291
LR + L LE ++ E L +D + + + R+ LE E ++LE A
Sbjct: 724 TLRETQEENDEFRRRILGLEQQLKETRGL---VDGGEAVEARLRDKLQRLEAEKQQLEEA 780
Query: 292 LSLWKWKYEEL---KESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICEL 348
L+ + + L K + ++E L + E Q L+ ++EE K + R EL
Sbjct: 781 LNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAEL 840
Query: 349 RAELERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPD 408
E +RL +K E EK G + + ++Q ++E+ +K R A++Q
Sbjct: 841 E-EQKRLLDRTVDRLNK----ELEKIGEDSKQALQQLQA-QLEDYKEKARREVADAQR-Q 893
Query: 409 FKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVD-----------QNEAE 457
K + ++ + L LQ +L + QA+ AE A R+D + EAE
Sbjct: 894 AKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTA--RLDKELLAQRLQGLEQEAE 951
Query: 458 VKKLRL--RVEELKQGLNQK----EDELDDSLNQIRKLQRSLDEEKERNENLETEL 507
KK R +LK GL +K E ELD+ N + L ++ +++ + L TEL
Sbjct: 952 NKKRSQDDRARQLK-GLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTEL 1006
Score = 46.2 bits (108), Expect = 7e-05
Identities = 109/501 (21%), Positives = 197/501 (39%), Gaps = 101/501 (20%)
Query: 71 EELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMA 130
E+LRLRE E + A E+ + +V R + + QLR ++ A
Sbjct: 488 EQLRLRERELTALKGALKEEVA-----------SRDQEVEHVRQQYQRDTEQLRRSMQDA 536
Query: 131 MKELSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIREYLVK 190
++ + L+ ++ + AL + ++L EE+ E T +Q Q +
Sbjct: 537 TQDHAVLEAERQ---KMSALVRGLQREL------EETSEETGHWQSMFQKN--------- 578
Query: 191 RQFSTKEDTNNKEQGVV---IDSLKLSEEMKPNLDGVDL-FNNGGSGNGETKTGLRLKAI 246
KED +Q ++ ++ ++ EE+ ++ + + G+T+ LK
Sbjct: 579 -----KEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKE 633
Query: 247 NLPLENEVTEISALQV-------HLD-EFQK---ILWKEREMRTALEKEIERLESALSLW 295
L + E+ E+ A + H D E +K +L E + LE++ +L+ L
Sbjct: 634 LLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQL 693
Query: 296 KWKYEELKESKPKNVKEFDI-LLGQH--------------NDEMQE----LSGNIKEESK 336
+ EE SK K V E + +LGQ NDE + L +KE
Sbjct: 694 RQDCEEA--SKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRG 751
Query: 337 SQNSKDRVICELRAELERLQAE--------NTSEWDKREI----------LEREKQGLER 378
+ + V LR +L+RL+AE N S+ ++ + LE ++GL R
Sbjct: 752 LVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLAR 811
Query: 379 E-------NRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYY 431
NR L+ + K+ E L K L + D + ++ N+EL +
Sbjct: 812 LGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRL-----NKELEKIGEDSK 866
Query: 432 KLNRQYQANIAELTH-ANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQ 490
+ +Q QA + + A V + + K E+ GL++ +DE+ ++ Q
Sbjct: 867 QALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQ 926
Query: 491 RSLDEEKERNENLETELRHLQ 511
D + E L L+ L+
Sbjct: 927 AERDTARLDKELLAQRLQGLE 947
Score = 45.8 bits (107), Expect = 9e-05
Identities = 55/269 (20%), Positives = 112/269 (41%), Gaps = 44/269 (16%)
Query: 251 ENEVT-EISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELKESKPKN 309
+ E+T ++ LQ LDE K K + LE+++E S + +EL E +
Sbjct: 361 QGELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECS----RLQELLERRKGE 416
Query: 310 VKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSE------- 362
+ Q N E+Q + + + ++ + + EL+ +L+ +Q ++
Sbjct: 417 AQ-------QSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDL 469
Query: 363 WDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQE 422
+ RE+LE +G +R +L+++ +E+ L K L S D ++ +
Sbjct: 470 LETRELLEEVLEGKQRVEEQLRLRERELTAL---KGALKEEVASRDQEVEHV-------- 518
Query: 423 LLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDS 482
+QYQ + +L + Q+ A ++ R ++ L +GL + EL+++
Sbjct: 519 -----------RQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQR---ELEET 564
Query: 483 LNQIRKLQRSLDEEKERNENLETELRHLQ 511
+ Q + KE + EL L+
Sbjct: 565 SEETGHWQSMFQKNKEDLRATKQELLQLR 593
Score = 42.0 bits (97), Expect = 0.001
Identities = 57/285 (20%), Positives = 116/285 (40%), Gaps = 23/285 (8%)
Query: 250 LENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALS-----------LWKWK 298
LE E L +++L + ++R LE ++ L++ L L K
Sbjct: 410 LERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDL 469
Query: 299 YE--ELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSK-DRVICELRAELERL 355
E EL E + + + L E+ L G +KEE S++ + + V + + + E+L
Sbjct: 470 LETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQL 529
Query: 356 QAENTSEWDKREILEREKQ-------GLERENRRLKIQVKEMEELLDK-KNRLSANSQSP 407
+ +LE E+Q GL+RE + + + K K L A Q
Sbjct: 530 RRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQEL 589
Query: 408 -DFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVE 466
+M + +++E+ E + + + R + ++ + + + E+K+L+ +
Sbjct: 590 LQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQ 649
Query: 467 ELKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRHLQ 511
+ ++ EL+ L +R E +E+N L+ L+ L+
Sbjct: 650 SQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLR 694
Score = 31.6 bits (70), Expect = 1.8
Identities = 16/57 (28%), Positives = 34/57 (59%), Gaps = 3/57 (5%)
Query: 459 KKLRLRVEE---LKQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETELRHLQN 512
++L + EE L++ L +++ E S +++ ++R LD+ ++ LET++ LQN
Sbjct: 394 RQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQVMELQN 450
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 67.8 bits (164), Expect = 2e-11
Identities = 98/460 (21%), Positives = 195/460 (42%), Gaps = 40/460 (8%)
Query: 76 RELEEVKARA--AQMEKTMRWW--SDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAM 131
+ELE KA + MEK R + + +++ S +R + A+ E ++L ++E+
Sbjct: 1048 KELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLR 1107
Query: 132 KELSTLKKKQSLPPQKEALE----ANVT-QDLKLPGFVEESCEHTDQFQLSSQMHESIRE 186
+E+ K+ L + + LE +++T Q L+ + +E+ Q QL + ES E
Sbjct: 1108 QEVKE-KEADFLAQEAQLLEELEASHITEQQLRASLWAQEA--KAAQLQLRLRSTESQLE 1164
Query: 187 YLVKRQFSTKEDTNNKEQGVVIDSLKLSE----EMKPNLDGVDLFNNGGSGNGETKTGLR 242
L Q + + + +L+ + E +P L G G + G R
Sbjct: 1165 ALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGAR 1224
Query: 243 LKAINLPLENEVTEISALQVH--LDEFQKILWKEREMRTALEKEIERLESALSLWKWKYE 300
PL +T +SA V L + + LWK ++ R L ++++LE L+ E
Sbjct: 1225 SLFKRGPL---LTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLT----DTE 1277
Query: 301 ELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENT 360
K +++ L Q+ +E + G + L++ L R + +
Sbjct: 1278 AEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRM 1337
Query: 361 SEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKN 420
+RE+L+ K+ L + L+ V E + +A D + ++ L+ KN
Sbjct: 1338 EAQGERELLQAAKENLTAQVEHLQAAVVEA-----RAQASAAGILEEDLRTARSALKLKN 1392
Query: 421 QELLNLQHAYYKLNRQYQANIAE-------LTHANNRVDQNEAEVKKLRLRVEELKQGLN 473
+E+ + + L Q + +A+ L + + E EV+ LR +++EL++
Sbjct: 1393 EEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQRE 1452
Query: 474 QKEDELDDSLNQIRKLQRSLDEEKERNENLE---TELRHL 510
++ L+ ++K + +D ++E+ + LE + L HL
Sbjct: 1453 MQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHL 1492
Score = 57.8 bits (138), Expect = 2e-08
Identities = 87/447 (19%), Positives = 184/447 (41%), Gaps = 48/447 (10%)
Query: 77 ELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMA-MKELS 135
E +V +++ + + + W K + + +E E L+ +L A ++ +
Sbjct: 1279 EKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRME 1338
Query: 136 TLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIREYLVKRQFST 195
+++ L KE L A V L V E+ Q + + E +R +
Sbjct: 1339 AQGERELLQAAKENLTAQVEH---LQAAVVEA---RAQASAAGILEEDLRTARSALKLKN 1392
Query: 196 KEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLENEVT 255
+E + +E+ +L+ E+K G L N L + L
Sbjct: 1393 EEVESERERA---QALQEQGELKV-AQGKALQEN-------------LALLTQTLAEREE 1435
Query: 256 EISALQVHLDEFQKILWKEREMRTA----LEKEIERLESALSLWKWKYEELKESK----- 306
E+ L+ + E +K +REM+ A L ++++ + L + + +EL++ +
Sbjct: 1436 EVETLRGQIQELEK----QREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEH 1491
Query: 307 -PKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWD- 364
P V+E + L ++++EL K+ +N + + EL + + ++++ D
Sbjct: 1492 LPMAVQEREQKLTVQREQIRELE---KDRETQRNVLEHQLLELEKKDQMIESQRGQVQDL 1548
Query: 365 KREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELL 424
K++++ E LE E K+ E ++ L K+ +Q +DL+E++QEL
Sbjct: 1549 KKQLVTLECLALELEENHHKM---ECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQ 1605
Query: 425 NLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSLN 484
+ L EL + V ++++L+ + E L Q L +++ EL +
Sbjct: 1606 AQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQEL---ML 1662
Query: 485 QIRKLQRSLDEEKERNENLETELRHLQ 511
Q ++Q D+ + + LE +L ++
Sbjct: 1663 QKERIQVLEDQRTRQTKILEEDLEQIK 1689
Score = 54.3 bits (129), Expect = 3e-07
Identities = 68/292 (23%), Positives = 132/292 (45%), Gaps = 52/292 (17%)
Query: 236 ETKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLW 295
E +T + LE E +S L+ +L ++E+ A +++ERL + +
Sbjct: 907 EERTQAESALCQMQLETEKERVSLLET-------LLQTQKELADA-SQQLERLRQDMKVQ 958
Query: 296 KWKYEE----LKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAE 351
K K +E L+ + +E QH D++ L +E S +D++ +L+ +
Sbjct: 959 KLKEQETTGILQTQLQEAQRELKEAARQHRDDLAAL-----QEESSSLLQDKM--DLQKQ 1011
Query: 352 LERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKM 411
+E L+++ ++ D + ++E+E Q RE + KE+E +K L+
Sbjct: 1012 VEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELER---EKASLT---------- 1058
Query: 412 SQIDLQEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQG 471
+ L EK Q LL LQ A + +Q EL+ + + + E K+L ++E L+Q
Sbjct: 1059 --LSLMEKEQRLLVLQEA-DSIRQQ------ELSALRQDMQEAQGEQKELSAQMELLRQE 1109
Query: 472 LNQKE-----------DELDDSLNQIRKLQRSLDEEKERNENLETELRHLQN 512
+ +KE +EL+ S ++L+ SL ++ + L+ LR ++
Sbjct: 1110 VKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTES 1161
Score = 52.8 bits (125), Expect = 8e-07
Identities = 89/449 (19%), Positives = 182/449 (40%), Gaps = 56/449 (12%)
Query: 103 REKWSKVRA----ERNSAREEGRQLRIKLEMAMKELSTLKKKQSLPPQKEALEA------ 152
REKW K R+ E A E + +++LEM +KE T + ++E +A
Sbjct: 859 REKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQ 918
Query: 153 -NVTQDLKLPGFVEESCEHTDQFQLSSQMHESIREYLVKRQFSTKEDTNNKEQGVVIDSL 211
+ + + +E + + +SQ E +R+ + ++ +E T + +
Sbjct: 919 MQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQR 978
Query: 212 KLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLENEVTEISALQVHLDEFQKIL 271
+L E + + D + S + K L+ + +L + + S V + +K+
Sbjct: 979 ELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKL- 1037
Query: 272 WKEREMRTALEKEIERLESALSLWKWKYEE----LKESKPKNVKEFDILLGQHNDEMQEL 327
+E + ++KE+ER +++L+L + E+ L+E+ +E L +MQE
Sbjct: 1038 -RETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSAL----RQDMQEA 1092
Query: 328 SGNIKEESKSQNSKDRVICELRAELERLQAENTSEWDKREILEREKQ----GLERENRRL 383
G KE S + + E A+ +A+ E + I E++ + E + +L
Sbjct: 1093 QGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQL 1152
Query: 384 KIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQELLNLQHAYYKLNRQYQANIAE 443
+++++ E L+ L+A Q + +Q +L +L A + + E
Sbjct: 1153 QLRLRSTESQLE---ALAAEQQPGNQAQAQ-------AQLASLYSALQQALGSVCESRPE 1202
Query: 444 LTHANNRV--------DQNEA-------------EVKKLRLRVEELKQGLNQKEDELDDS 482
L+ + DQN A + + + +L Q L + + D
Sbjct: 1203 LSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVL 1262
Query: 483 LNQIRKLQRSLDEEKERNENLETELRHLQ 511
+Q++KL+ L + + + TEL+ LQ
Sbjct: 1263 RDQVQKLEERLTDTEAEKSQVHTELQDLQ 1291
Score = 52.0 bits (123), Expect = 1e-06
Identities = 59/277 (21%), Positives = 122/277 (44%), Gaps = 19/277 (6%)
Query: 251 ENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELKE-----S 305
E T++ L +++L + + + AL +E LE L + ++L E S
Sbjct: 704 EAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLS 763
Query: 306 KPKNVKEFDILLGQHNDEMQELS-GNIKEESKSQNSKDRVI------CELRAELERLQAE 358
K + E + Q + + E++ G ++ + ++ VI +L + ER QAE
Sbjct: 764 SAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAE 823
Query: 359 NTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQE 418
+ R++ + E++G ++ KE+ +L +K + + Q K + +E
Sbjct: 824 QERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLERE 883
Query: 419 KNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDE 478
K + + L+ ++ E T A + + Q + E +K R+ L + L Q + E
Sbjct: 884 KMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERV---SLLETLLQTQKE 940
Query: 479 LDDSLNQIRKLQRSLD----EEKERNENLETELRHLQ 511
L D+ Q+ +L++ + +E+E L+T+L+ Q
Sbjct: 941 LADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQ 977
Score = 47.8 bits (112), Expect = 2e-05
Identities = 92/459 (20%), Positives = 198/459 (43%), Gaps = 79/459 (17%)
Query: 74 RLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAMKE 133
+++ELE+ + +M+K R + ++ E+ E+ R + L MA++E
Sbjct: 1443 QIQELEKQR----EMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQE 1498
Query: 134 LSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHE-SIREYLVKRQ 192
++Q L Q+E + E T + L Q+ E ++ +++ Q
Sbjct: 1499 -----REQKLTVQREQIREL------------EKDRETQRNVLEHQLLELEKKDQMIESQ 1541
Query: 193 FSTKEDTNNKEQGVVIDSLKLS-EEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLE 251
+D K+Q V ++ L L EE ++ G ET+ + L + L LE
Sbjct: 1542 RGQVQDL--KKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQR-VALTHLTLDLE 1598
Query: 252 NEVTEISAL--QVH-LDEFQKILWKEREMRTA------------------LEKEIERLES 290
E+ A Q+H L+ +L +E + R L +++ER +
Sbjct: 1599 ERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQ 1658
Query: 291 ALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRA 350
L L K + + L++ + + K + ++++++ +++E + ++ +++ E RA
Sbjct: 1659 ELMLQKERIQVLEDQRTRQTKILE-------EDLEQIKLSLRERGRELTTQRQLMQE-RA 1710
Query: 351 ELERLQAENTSEWDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFK 410
E + + S+ +R LE K L + + ++ Q + + EL + K++L Q K
Sbjct: 1711 E----EGKGPSK-AQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRK 1765
Query: 411 MSQIDL--QEKNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEEL 468
+ + L ++ QE++ LQ +L A +Q E + + L+ +++E
Sbjct: 1766 VGETSLLLSQREQEIVVLQQ--------------QLQEAR---EQGELKEQSLQSQLDEA 1808
Query: 469 KQGLNQKEDELDDSLNQIRKLQRSLDEEKERNENLETEL 507
++ L Q++ EL+ + ++ Q + KE+ + L+ L
Sbjct: 1809 QRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGAL 1847
Score = 47.4 bits (111), Expect = 3e-05
Identities = 91/464 (19%), Positives = 178/464 (38%), Gaps = 79/464 (17%)
Query: 79 EEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEMAMKELSTLK 138
+E++A+++Q+ + +E+ +V+++R E RQ E ++L +
Sbjct: 1602 QELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQK----EHLTQDLE--R 1655
Query: 139 KKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIREYLVKRQFSTKED 198
+ Q L QKE ++ Q + +EE E Q+ + E RE +RQ +
Sbjct: 1656 RDQELMLQKERIQVLEDQRTRQTKILEEDLE-----QIKLSLRERGRELTTQRQLMQER- 1709
Query: 199 TNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAINLPLENEVTEIS 258
+EE G G + + G L+ + L L ++ E+
Sbjct: 1710 ---------------AEE--------------GKGPSKAQRG-SLEHMKLILRDKEKEVE 1739
Query: 259 ALQVHLDEFQKILWKEREMRTAL--------------EKEIERLESALSLWKWKYEELKE 304
Q H+ E Q++ + + L E+EI L+ L + + E ++
Sbjct: 1740 CQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQ 1799
Query: 305 SKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEWD 364
S + E L Q + E++ L +E+ ++Q ++RV + A L+ + + +
Sbjct: 1800 SLQSQLDEAQRALAQRDQELEALQ---QEQQQAQGQEERVKEKADALQGALEQAHMTLKE 1856
Query: 365 KREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQI------DLQE 418
+ L+ K+ R L ++ + ++ L + L A S+ + + + QE
Sbjct: 1857 RHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQE 1916
Query: 419 KNQELLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQ---- 474
E LQ ++ + + EL + + + R R E L++ L +
Sbjct: 1917 HEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAA 1976
Query: 475 ---------KEDELDDSLN-QIRKLQRSLDEEKERNENLETELR 508
++ EL SL LQ SLD + + LE LR
Sbjct: 1977 LQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALR 2020
Score = 46.6 bits (109), Expect = 5e-05
Identities = 64/258 (24%), Positives = 111/258 (43%), Gaps = 32/258 (12%)
Query: 271 LWKEREMRTALEKEIERLESALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGN 330
L KERE+ L+K E L L + + + L+ + + D GQ ++ +EL
Sbjct: 461 LSKEREL---LQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLA 517
Query: 331 IKEESKSQNSKDRVICELRAELERLQAENTSEW-DKREILER---EKQGLERENRRLKIQ 386
++E + Q E+ LE Q+E+ SE RE LE E + L +E +
Sbjct: 518 VRERERLQ--------EMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAA 569
Query: 387 VKEME----ELLDKKNRLS---ANSQSPDFKMSQI------DLQEKNQELLNLQHAYYKL 433
+ E EL +N L A+ ++ K+S + D NQ+LL L+
Sbjct: 570 LARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEE---- 625
Query: 434 NRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIRKLQRSL 493
N+ + + A N + + AE +K R + E L + + +++ +++ R +
Sbjct: 626 NQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDI 685
Query: 494 DEEKERNENLETELRHLQ 511
EEKE + +E RH Q
Sbjct: 686 QEEKEEIQKKLSESRHQQ 703
Score = 41.2 bits (95), Expect = 0.002
Identities = 95/444 (21%), Positives = 188/444 (42%), Gaps = 69/444 (15%)
Query: 70 CEELRLRELEEVKARAAQ----MEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRI 125
C++ + EL+E+K + Q + + + S + ++ ++ + ARE+G
Sbjct: 1740 CQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQ 1799
Query: 126 KLEMAMKELSTLKKKQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLS-SQMHESI 184
L+ + E +++L + + LEA + + G E E D Q + Q H ++
Sbjct: 1800 SLQSQLDEA-----QRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTL 1854
Query: 185 REYLVKRQFSTKEDTNNKEQGVVIDSLKLS--EEMKPNLDGVDLFNNGGSGNGETKTGLR 242
+E + Q KE E+ + ++ ++ EE+ +L + L+
Sbjct: 1855 KERHGELQ-DHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQE------KALLALQ 1907
Query: 243 LKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEEL 302
+ E+EV E ALQ + Q +L KER+ E E R ES S + EE
Sbjct: 1908 QQCAEQAQEHEV-ETRALQDSWLQAQAVL-KERDQ----ELEALRAESQSSRHQ---EEA 1958
Query: 303 KESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSE 362
++ + ++E LG+ + +Q ++ E+++ S + L+A L+ QA +
Sbjct: 1959 ARARAEALQE---ALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQL 2015
Query: 363 WDKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQE 422
+ I E E ++ ++ R + V+++++ L +++ ++ Q++ ++
Sbjct: 2016 EEALRIQEGE---IQDQDLRYQEDVQQLQQALAQRDE-------------ELRHQQEREQ 2059
Query: 423 LLNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKL--RLRVEELKQGLNQKEDELD 480
LL A RV +N + K+ + R EE +GL+Q EL
Sbjct: 2060 LLEKSLA-------------------QRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQ 2100
Query: 481 DSLNQIRKLQRSLDEEKERNENLE 504
+L Q + L E ++RN NLE
Sbjct: 2101 LTLAQKEQEILELRETQQRN-NLE 2123
Score = 35.8 bits (81), Expect = 0.096
Identities = 55/261 (21%), Positives = 107/261 (40%), Gaps = 35/261 (13%)
Query: 282 EKEIERLESALSLWKWKYEELKESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSK 341
+K + + S L+ + ++L++ + ++L QH+ +E + K +
Sbjct: 385 DKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGER 444
Query: 342 DRVI---CELRAELERLQAENTSEWDKR-------EILEREKQGLERENRRLKIQ----- 386
D + +L+ E++ L E R E+LE+E L R N L++Q
Sbjct: 445 DTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQ 504
Query: 387 ---VKEMEEL---LDKKNRLSANSQSPDFKMSQIDLQE--KNQELLNLQHAYYKLNRQYQ 438
++ EEL + ++ RL + K S+ L E +E L H +L RQ Q
Sbjct: 505 GQKEEQQEELHLAVRERERLQEMLMGLEAKQSE-SLSELITLREALESSHLEGELLRQEQ 563
Query: 439 A-----------NIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSLNQIR 487
+IAEL+ + N + A+++ +++ L + L + L+ L Q+
Sbjct: 564 TEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLE 623
Query: 488 KLQRSLDEEKERNENLETELR 508
+ +S+ E E L+
Sbjct: 624 EENQSVCSRMEAAEQARNALQ 644
Score = 32.0 bits (71), Expect = 1.4
Identities = 62/305 (20%), Positives = 119/305 (39%), Gaps = 61/305 (20%)
Query: 117 REEGRQLRIKLEMAMKELSTLKKKQSLPPQKEA--LEANVTQDLKLPGFVEESCEHTDQF 174
+E+ +QL+ L +EL ++++ L + A ++ N+ Q+ + G E E
Sbjct: 2034 QEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRG-- 2091
Query: 175 QLSSQMHESIREYLVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGN 234
+H+S+RE + KEQ + L+L E + N ++ + +
Sbjct: 2092 -----LHQSVRELQLTLA--------QKEQEI----LELRETQQRN--NLEALPHSHKTS 2132
Query: 235 GETKTGLRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTAL------------- 281
+ L+L ++ L+ E+ + A + E ++I W+E+ AL
Sbjct: 2133 PMEEQSLKLDSLEPRLQRELERLQAA-LRQTEAREIEWREKAQDLALSLAQTKASVSSLQ 2191
Query: 282 -------------EKEIERLESALSLWKWKYEELKESKPKNVKEFDI-LLGQHNDEMQEL 327
+ E +RL+ L L + E+ + P ++ G+ ++ E+
Sbjct: 2192 EVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEV 2251
Query: 328 SGNIKEESKSQNSKD----------RVICELRAELERLQAENTSEWDKREILEREKQGLE 377
SG E S K + + L + RLQ N E +ERE++ L+
Sbjct: 2252 SGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLK 2311
Query: 378 RENRR 382
RE R
Sbjct: 2312 REAMR 2316
Score = 31.2 bits (69), Expect = 2.4
Identities = 58/308 (18%), Positives = 128/308 (41%), Gaps = 45/308 (14%)
Query: 241 LRLKAINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYE 300
++ +++ L LE +V ALQ + E Q W++ + ++ L L +Y
Sbjct: 11 MKPQSLQLVLEEQVL---ALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYR 67
Query: 301 ELKESKPKNVKEFDILLGQHNDEMQE-----LSGNIKEESKSQNSKDRVICELRAELERL 355
+ K ++ + Q + ++E L ++EE + S V +LR +E+
Sbjct: 68 SWCQELEKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKA 127
Query: 356 QAEN----------TSEWDK-REILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANS 404
N T +W + R+ L R++ + E K +K L LS
Sbjct: 128 DVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRL-----LSLWR 182
Query: 405 QSPDFKMSQIDLQEK-NQELLNLQHAYYKLNRQYQANIAELT--------HANNRVDQNE 455
+ F+ ++++ +++L+ L+ + +L+ LT + + R+D E
Sbjct: 183 EVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGRE 242
Query: 456 -AEVKKLRLRVEELKQGLNQKEDELDDSLNQ-----------IRKLQRSLDEEKERNENL 503
A++ L + +EL++ +++ EL +Q + +L L + +++NE+
Sbjct: 243 PAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDY 302
Query: 504 ETELRHLQ 511
E ++ L+
Sbjct: 303 EKMIKALR 310
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.127 0.355
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,704,104
Number of Sequences: 37866
Number of extensions: 853220
Number of successful extensions: 10236
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 354
Number of HSP's successfully gapped in prelim test: 905
Number of HSP's that attempted gapping in prelim test: 4594
Number of HSP's gapped (non-prelim): 3798
length of query: 513
length of database: 18,247,518
effective HSP length: 107
effective length of query: 406
effective length of database: 14,195,856
effective search space: 5763517536
effective search space used: 5763517536
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.