Search of human proteins with 14790124

Search of human proteins with 14790124

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|14790124 caspase 9 isoform alpha preproprotein [Homo
sapiens]
         (416 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|14790124 caspase 9 isoform alpha preproprotein [Homo sapiens]      843   0.0  
gi|14790128 caspase 9 isoform beta preproprotein [Homo sapiens]       275   4e-74
gi|14790115 caspase 3 preproprotein [Homo sapiens]                    155   6e-38
gi|14790119 caspase 3 preproprotein [Homo sapiens]                    155   6e-38
gi|39995059 caspase 2 isoform 1 preproprotein [Homo sapiens]          148   8e-36
gi|122056476 caspase 8 isoform G precursor [Homo sapiens]             139   4e-33
gi|122056474 caspase 8 isoform C precursor [Homo sapiens]             139   4e-33
gi|15718708 caspase 8 isoform C precursor [Homo sapiens]              139   4e-33
gi|15718706 caspase 8 isoform B precursor [Homo sapiens]              139   4e-33
gi|15718704 caspase 8 isoform A precursor [Homo sapiens]              139   4e-33
gi|15718698 caspase 7 isoform delta [Homo sapiens]                    134   2e-31
gi|15718700 caspase 7 isoform alpha [Homo sapiens]                    134   2e-31
gi|4502581 caspase 7 isoform alpha precursor [Homo sapiens]           134   2e-31
gi|47078267 caspase 10 isoform a preproprotein [Homo sapiens]         124   1e-28
gi|47078272 caspase 10 isoform d preproprotein [Homo sapiens]         122   6e-28
gi|14916483 caspase 6 isoform alpha preproprotein [Homo sapiens]      115   1e-25
gi|47078269 caspase 10 isoform b preproprotein [Homo sapiens]         108   7e-24
gi|15431328 caspase 1 isoform alpha precursor [Homo sapiens]           89   1e-17
gi|6912286 caspase 14 precursor [Homo sapiens]                         86   8e-17
gi|14916485 caspase 6 isoform beta [Homo sapiens]                      84   2e-16
gi|4502573 caspase 1 isoform beta precursor [Homo sapiens]             83   4e-16
gi|15431330 caspase 1 isoform gamma precursor [Homo sapiens]           77   2e-14
gi|15451910 caspase 4 isoform gamma precursor [Homo sapiens]           74   3e-13
gi|4502577 caspase 4 isoform alpha precursor [Homo sapiens]            74   3e-13
gi|209870079 caspase 5 isoform f precursor [Homo sapiens]              74   3e-13
gi|209870073 caspase 5 isoform c [Homo sapiens]                        74   3e-13
gi|209870071 caspase 5 isoform b precursor [Homo sapiens]              74   3e-13
gi|209870069 caspase 5 isoform a precursor [Homo sapiens]              74   3e-13
gi|239756464 PREDICTED: hypothetical protein LOC197350 [Homo sap...    66   5e-11
gi|169210653 PREDICTED: hypothetical protein LOC197350 [Homo sap...    66   5e-11

>gi|14790124 caspase 9 isoform alpha preproprotein [Homo sapiens]
          Length = 416

 Score =  843 bits (2178), Expect = 0.0
 Identities = 416/416 (100%), Positives = 416/416 (100%)

Query: 1   MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLII 60
           MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLII
Sbjct: 1   MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLII 60

Query: 61  DLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEV 120
           DLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEV
Sbjct: 61  DLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEV 120

Query: 121 LRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTR 180
           LRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTR
Sbjct: 121 LRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTR 180

Query: 181 TGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQ 240
           TGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQ
Sbjct: 181 TGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQ 240

Query: 241 ASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVAS 300
           ASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVAS
Sbjct: 241 ASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVAS 300

Query: 301 TSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSG 360
           TSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSG
Sbjct: 301 TSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSG 360

Query: 361 SWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS 416
           SWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS
Sbjct: 361 SWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS 416


>gi|14790128 caspase 9 isoform beta preproprotein [Homo sapiens]
          Length = 266

 Score =  275 bits (704), Expect = 4e-74
 Identities = 139/139 (100%), Positives = 139/139 (100%)

Query: 1   MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLII 60
           MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLII
Sbjct: 1   MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLII 60

Query: 61  DLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEV 120
           DLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEV
Sbjct: 61  DLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEV 120

Query: 121 LRPETPRPVDIGSGGFGDV 139
           LRPETPRPVDIGSGGFGDV
Sbjct: 121 LRPETPRPVDIGSGGFGDV 139



 Score =  265 bits (677), Expect = 6e-71
 Identities = 127/127 (100%), Positives = 127/127 (100%)

Query: 290 EQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFP 349
           EQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFP
Sbjct: 140 EQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFP 199

Query: 350 GFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRK 409
           GFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRK
Sbjct: 200 GFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRK 259

Query: 410 KLFFKTS 416
           KLFFKTS
Sbjct: 260 KLFFKTS 266


>gi|14790115 caspase 3 preproprotein [Homo sapiens]
          Length = 277

 Score =  155 bits (392), Expect = 6e-38
 Identities = 91/274 (33%), Positives = 142/274 (51%), Gaps = 42/274 (15%)

Query: 150 DLAYILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTA 209
           D +Y +     G C+IINN NF + +G+ +R+G+++D   LR  F +L + V  K DLT 
Sbjct: 34  DNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTR 93

Query: 210 KKMVLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNG 269
           +++V  + +++++DH      V V+LSHG +       G ++GT+G PV ++KI N F G
Sbjct: 94  EEIVELMRDVSKEDHSKRSSFVCVLLSHGEE-------GIIFGTNG-PVDLKKITNFFRG 145

Query: 270 TSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQL 329
             C SL GKPKLF IQAC G + D G E  S   +D                        
Sbjct: 146 DRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDM----------------------- 182

Query: 330 DAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVAN 389
            A   +P  +D   +YST PG+ SWR+ K GSW++++L  + +Q+A   +   +L RV  
Sbjct: 183 -ACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNR 241

Query: 390 AVSVK----------GIYKQMPGCFNFLRKKLFF 413
            V+ +             KQ+P   + L K+L+F
Sbjct: 242 KVATEFESFSFDATFHAKKQIPCIVSMLTKELYF 275


>gi|14790119 caspase 3 preproprotein [Homo sapiens]
          Length = 277

 Score =  155 bits (392), Expect = 6e-38
 Identities = 91/274 (33%), Positives = 142/274 (51%), Gaps = 42/274 (15%)

Query: 150 DLAYILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTA 209
           D +Y +     G C+IINN NF + +G+ +R+G+++D   LR  F +L + V  K DLT 
Sbjct: 34  DNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTR 93

Query: 210 KKMVLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNG 269
           +++V  + +++++DH      V V+LSHG +       G ++GT+G PV ++KI N F G
Sbjct: 94  EEIVELMRDVSKEDHSKRSSFVCVLLSHGEE-------GIIFGTNG-PVDLKKITNFFRG 145

Query: 270 TSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQL 329
             C SL GKPKLF IQAC G + D G E  S   +D                        
Sbjct: 146 DRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDM----------------------- 182

Query: 330 DAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVAN 389
            A   +P  +D   +YST PG+ SWR+ K GSW++++L  + +Q+A   +   +L RV  
Sbjct: 183 -ACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNR 241

Query: 390 AVSVK----------GIYKQMPGCFNFLRKKLFF 413
            V+ +             KQ+P   + L K+L+F
Sbjct: 242 KVATEFESFSFDATFHAKKQIPCIVSMLTKELYF 275


>gi|39995059 caspase 2 isoform 1 preproprotein [Homo sapiens]
          Length = 452

 Score =  148 bits (374), Expect = 8e-36
 Identities = 119/391 (30%), Positives = 180/391 (46%), Gaps = 32/391 (8%)

Query: 9   LRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQ-RAGSGSRRDQARQLIIDLETRGS 67
           L++ R+ L ++L + +L + LL +++    M E IQ + GS S+  +   L   L  RG 
Sbjct: 40  LKKNRVVLAKQLLLSELLEHLLEKDIITLEMRELIQAKVGSFSQNVELLNL---LPKRGP 96

Query: 68  QALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLR-------PEIRKPEV 120
           QA   F   L +T Q  L   L T     +   P L     + L        P  +K  +
Sbjct: 97  QAFDAFCEALRETKQGHLEDMLLTTLSGLQHVLPPLSCDYDLSLPFPVCESCPLYKKLRL 156

Query: 121 LRPETPRPVDIGSGGFG---DVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGL 177
                   +D   G           E  + +  LAY L   P G  L+++NV+F  E  L
Sbjct: 157 STDTVEHSLDNKDGPVCLQVKPCTPEFYQTHFQLAYRLQSRPRGLALVLSNVHFTGEKEL 216

Query: 178 RTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQD-HGALDCCVVVILS 236
             R+G ++D   L   F  L + V V  D TA++M   L   AQ   H   D C+V +LS
Sbjct: 217 EFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEMQEKLQNFAQLPAHRVTDSCIVALLS 276

Query: 237 HGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGF 296
           HG +       GA+YG DG  + ++++  +F+  +CPSL  KPK+FFIQAC G++ D G 
Sbjct: 277 HGVE-------GAIYGVDGKLLQLQEVFQLFDNANCPSLQNKPKMFFIQACRGDETDRGV 329

Query: 297 EVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRD 356
           +         SPG   E DA     G     ++     LPT SD+   Y+   G  + R+
Sbjct: 330 DQQDGKNHAGSPGCE-ESDA-----GKEKLPKM----RLPTRSDMICGYACLKGTAAMRN 379

Query: 357 PKSGSWYVETLDDIFEQWAHSEDLQSLLLRV 387
            K GSWY+E L  +F + A    +  +L++V
Sbjct: 380 TKRGSWYIEALAQVFSERACDMHVADMLVKV 410


>gi|122056476 caspase 8 isoform G precursor [Homo sapiens]
          Length = 538

 Score =  139 bits (351), Expect = 4e-33
 Identities = 91/276 (32%), Positives = 134/276 (48%), Gaps = 34/276 (12%)

Query: 150 DLAYILSMEPCGHCLIINNVNFCRES-------GLRTRTGSNIDCEKLRRRFSSLHFMVE 202
           D  Y +  +P G+CLIINN NF +          +R R G+++D   L   F  LHF ++
Sbjct: 282 DKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIK 341

Query: 203 VKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEK 262
              D T +++   L      DH  +DC +  ILSHG +       G +YGTDG    + +
Sbjct: 342 PHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDK-------GIIYGTDGQEAPIYE 394

Query: 263 IVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEG 322
           + + F G  CPSL GKPK+FFIQAC G+    G  V + S E             P+ E 
Sbjct: 395 LTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQ------------PYLEM 442

Query: 323 LRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETL-DDIFEQWAHSEDLQ 381
             +  Q   I   P  +D  +  +T    VS+R+P  G+WY+++L   + E+    +D+ 
Sbjct: 443 DLSSPQTRYI---PDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDIL 499

Query: 382 SLL----LRVANAVSVKGIYKQMPGCFNFLRKKLFF 413
           ++L      V+N    K + KQMP     LRKKL F
Sbjct: 500 TILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVF 535


>gi|122056474 caspase 8 isoform C precursor [Homo sapiens]
          Length = 464

 Score =  139 bits (351), Expect = 4e-33
 Identities = 91/276 (32%), Positives = 134/276 (48%), Gaps = 34/276 (12%)

Query: 150 DLAYILSMEPCGHCLIINNVNFCRES-------GLRTRTGSNIDCEKLRRRFSSLHFMVE 202
           D  Y +  +P G+CLIINN NF +          +R R G+++D   L   F  LHF ++
Sbjct: 208 DKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIK 267

Query: 203 VKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEK 262
              D T +++   L      DH  +DC +  ILSHG +       G +YGTDG    + +
Sbjct: 268 PHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDK-------GIIYGTDGQEAPIYE 320

Query: 263 IVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEG 322
           + + F G  CPSL GKPK+FFIQAC G+    G  V + S E             P+ E 
Sbjct: 321 LTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQ------------PYLEM 368

Query: 323 LRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETL-DDIFEQWAHSEDLQ 381
             +  Q   I   P  +D  +  +T    VS+R+P  G+WY+++L   + E+    +D+ 
Sbjct: 369 DLSSPQTRYI---PDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDIL 425

Query: 382 SLL----LRVANAVSVKGIYKQMPGCFNFLRKKLFF 413
           ++L      V+N    K + KQMP     LRKKL F
Sbjct: 426 TILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVF 461


>gi|15718708 caspase 8 isoform C precursor [Homo sapiens]
          Length = 464

 Score =  139 bits (351), Expect = 4e-33
 Identities = 91/276 (32%), Positives = 134/276 (48%), Gaps = 34/276 (12%)

Query: 150 DLAYILSMEPCGHCLIINNVNFCRES-------GLRTRTGSNIDCEKLRRRFSSLHFMVE 202
           D  Y +  +P G+CLIINN NF +          +R R G+++D   L   F  LHF ++
Sbjct: 208 DKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIK 267

Query: 203 VKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEK 262
              D T +++   L      DH  +DC +  ILSHG +       G +YGTDG    + +
Sbjct: 268 PHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDK-------GIIYGTDGQEAPIYE 320

Query: 263 IVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEG 322
           + + F G  CPSL GKPK+FFIQAC G+    G  V + S E             P+ E 
Sbjct: 321 LTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQ------------PYLEM 368

Query: 323 LRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETL-DDIFEQWAHSEDLQ 381
             +  Q   I   P  +D  +  +T    VS+R+P  G+WY+++L   + E+    +D+ 
Sbjct: 369 DLSSPQTRYI---PDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDIL 425

Query: 382 SLL----LRVANAVSVKGIYKQMPGCFNFLRKKLFF 413
           ++L      V+N    K + KQMP     LRKKL F
Sbjct: 426 TILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVF 461


>gi|15718706 caspase 8 isoform B precursor [Homo sapiens]
          Length = 479

 Score =  139 bits (351), Expect = 4e-33
 Identities = 91/276 (32%), Positives = 134/276 (48%), Gaps = 34/276 (12%)

Query: 150 DLAYILSMEPCGHCLIINNVNFCRES-------GLRTRTGSNIDCEKLRRRFSSLHFMVE 202
           D  Y +  +P G+CLIINN NF +          +R R G+++D   L   F  LHF ++
Sbjct: 223 DKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIK 282

Query: 203 VKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEK 262
              D T +++   L      DH  +DC +  ILSHG +       G +YGTDG    + +
Sbjct: 283 PHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDK-------GIIYGTDGQEAPIYE 335

Query: 263 IVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEG 322
           + + F G  CPSL GKPK+FFIQAC G+    G  V + S E             P+ E 
Sbjct: 336 LTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQ------------PYLEM 383

Query: 323 LRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETL-DDIFEQWAHSEDLQ 381
             +  Q   I   P  +D  +  +T    VS+R+P  G+WY+++L   + E+    +D+ 
Sbjct: 384 DLSSPQTRYI---PDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDIL 440

Query: 382 SLL----LRVANAVSVKGIYKQMPGCFNFLRKKLFF 413
           ++L      V+N    K + KQMP     LRKKL F
Sbjct: 441 TILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVF 476


>gi|15718704 caspase 8 isoform A precursor [Homo sapiens]
          Length = 496

 Score =  139 bits (351), Expect = 4e-33
 Identities = 91/276 (32%), Positives = 134/276 (48%), Gaps = 34/276 (12%)

Query: 150 DLAYILSMEPCGHCLIINNVNFCRES-------GLRTRTGSNIDCEKLRRRFSSLHFMVE 202
           D  Y +  +P G+CLIINN NF +          +R R G+++D   L   F  LHF ++
Sbjct: 240 DKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIK 299

Query: 203 VKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEK 262
              D T +++   L      DH  +DC +  ILSHG +       G +YGTDG    + +
Sbjct: 300 PHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDK-------GIIYGTDGQEAPIYE 352

Query: 263 IVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEG 322
           + + F G  CPSL GKPK+FFIQAC G+    G  V + S E             P+ E 
Sbjct: 353 LTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQ------------PYLEM 400

Query: 323 LRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETL-DDIFEQWAHSEDLQ 381
             +  Q   I   P  +D  +  +T    VS+R+P  G+WY+++L   + E+    +D+ 
Sbjct: 401 DLSSPQTRYI---PDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDIL 457

Query: 382 SLL----LRVANAVSVKGIYKQMPGCFNFLRKKLFF 413
           ++L      V+N    K + KQMP     LRKKL F
Sbjct: 458 TILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVF 493


>gi|15718698 caspase 7 isoform delta [Homo sapiens]
          Length = 336

 Score =  134 bits (337), Expect = 2e-31
 Identities = 88/271 (32%), Positives = 130/271 (47%), Gaps = 39/271 (14%)

Query: 153 YILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKM 212
           Y ++ E  G C+IINN NF + +G+  R G++ D E L + F SL F V V  D +  KM
Sbjct: 93  YNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKM 152

Query: 213 VLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSC 272
              L + +++DH    C   ++LSHG +         +YG DG    ++ +   F G  C
Sbjct: 153 QDLLKKASEEDHTNAACFACILLSHGEE-------NVIYGKDGV-TPIKDLTAHFRGDRC 204

Query: 273 PSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAI 332
            +L  KPKLFFIQAC G + D G +  S        G   + DA P  +           
Sbjct: 205 KTLLEKPKLFFIQACRGTELDDGIQADS--------GPINDTDANPRYK----------- 245

Query: 333 SSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVS 392
             +P  +D   +YST PG+ SWR P  GSW+V+ L  I E+     ++  +L RV + V+
Sbjct: 246 --IPVEADFLFAYSTVPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQILTRVNDRVA 303

Query: 393 VK----------GIYKQMPGCFNFLRKKLFF 413
                          KQ+P   + L K+L+F
Sbjct: 304 RHFESQSDDPHFHEKKQIPCVVSMLTKELYF 334


>gi|15718700 caspase 7 isoform alpha [Homo sapiens]
          Length = 303

 Score =  134 bits (337), Expect = 2e-31
 Identities = 88/271 (32%), Positives = 130/271 (47%), Gaps = 39/271 (14%)

Query: 153 YILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKM 212
           Y ++ E  G C+IINN NF + +G+  R G++ D E L + F SL F V V  D +  KM
Sbjct: 60  YNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKM 119

Query: 213 VLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSC 272
              L + +++DH    C   ++LSHG +         +YG DG    ++ +   F G  C
Sbjct: 120 QDLLKKASEEDHTNAACFACILLSHGEE-------NVIYGKDGV-TPIKDLTAHFRGDRC 171

Query: 273 PSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAI 332
            +L  KPKLFFIQAC G + D G +  S        G   + DA P  +           
Sbjct: 172 KTLLEKPKLFFIQACRGTELDDGIQADS--------GPINDTDANPRYK----------- 212

Query: 333 SSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVS 392
             +P  +D   +YST PG+ SWR P  GSW+V+ L  I E+     ++  +L RV + V+
Sbjct: 213 --IPVEADFLFAYSTVPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQILTRVNDRVA 270

Query: 393 VK----------GIYKQMPGCFNFLRKKLFF 413
                          KQ+P   + L K+L+F
Sbjct: 271 RHFESQSDDPHFHEKKQIPCVVSMLTKELYF 301


>gi|4502581 caspase 7 isoform alpha precursor [Homo sapiens]
          Length = 303

 Score =  134 bits (337), Expect = 2e-31
 Identities = 88/271 (32%), Positives = 130/271 (47%), Gaps = 39/271 (14%)

Query: 153 YILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKM 212
           Y ++ E  G C+IINN NF + +G+  R G++ D E L + F SL F V V  D +  KM
Sbjct: 60  YNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKM 119

Query: 213 VLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSC 272
              L + +++DH    C   ++LSHG +         +YG DG    ++ +   F G  C
Sbjct: 120 QDLLKKASEEDHTNAACFACILLSHGEE-------NVIYGKDGV-TPIKDLTAHFRGDRC 171

Query: 273 PSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAI 332
            +L  KPKLFFIQAC G + D G +  S        G   + DA P  +           
Sbjct: 172 KTLLEKPKLFFIQACRGTELDDGIQADS--------GPINDTDANPRYK----------- 212

Query: 333 SSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVS 392
             +P  +D   +YST PG+ SWR P  GSW+V+ L  I E+     ++  +L RV + V+
Sbjct: 213 --IPVEADFLFAYSTVPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQILTRVNDRVA 270

Query: 393 VK----------GIYKQMPGCFNFLRKKLFF 413
                          KQ+P   + L K+L+F
Sbjct: 271 RHFESQSDDPHFHEKKQIPCVVSMLTKELYF 301


>gi|47078267 caspase 10 isoform a preproprotein [Homo sapiens]
          Length = 479

 Score =  124 bits (312), Expect = 1e-28
 Identities = 107/346 (30%), Positives = 161/346 (46%), Gaps = 48/346 (13%)

Query: 74  ISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEVLRPETPRPVDIGS 133
           ++CLED  + ++   LR       + K   E    +V  P  ++ E  + E         
Sbjct: 167 LTCLEDLCKTVVPKLLRN------IEKYKREKAIQIVTPPVDKEAESYQGEEELVSQTDV 220

Query: 134 GGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRR 193
             F     LE+L   A   Y ++    G C+I+NN +F   + L+ R G++ D E L   
Sbjct: 221 KTF-----LEALPRAA--VYRMNRNHRGLCVIVNNHSF---TSLKDRQGTHKDAEILSHV 270

Query: 194 FSSLHFMVEVKGDLTAKKMVLALL-ELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYG 252
           F  L F V +  ++T  +M + L  +     H   DC V  IL+HG      +F GAVY 
Sbjct: 271 FQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHG------RF-GAVYS 323

Query: 253 TDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNP 312
           +D   + + +I++ F    CP L  KPKLFFIQAC GE+          S   E+   NP
Sbjct: 324 SDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEE-------IQPSVSIEADALNP 376

Query: 313 EPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFE 372
           E   T  Q+            S+P  +D  +  +T PG+VS+R  + GSWY+++L +  +
Sbjct: 377 EQAPTSLQD------------SIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLK 424

Query: 373 QWA-HSEDLQSLLLRVANAVS----VKGIYKQMPGCFNFLRKKLFF 413
           +     ED+ S+L  V + VS     +G  KQMP     LRKKL F
Sbjct: 425 KLVPRHEDILSILTAVNDDVSRRVDKQGTKKQMPQPAFTLRKKLVF 470


>gi|47078272 caspase 10 isoform d preproprotein [Homo sapiens]
          Length = 522

 Score =  122 bits (306), Expect = 6e-28
 Identities = 90/267 (33%), Positives = 133/267 (49%), Gaps = 35/267 (13%)

Query: 153 YILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKM 212
           Y ++    G C+I+NN +F   + L+ R G++ D E L   F  L F V +  ++T  +M
Sbjct: 276 YRMNRNHRGLCVIVNNHSF---TSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEM 332

Query: 213 VLALL-ELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTS 271
            + L  +     H   DC V  IL+HG      +F GAVY +D   + + +I++ F    
Sbjct: 333 EMVLQKQKCNPAHADGDCFVFCILTHG------RF-GAVYSSDEALIPIREIMSHFTALQ 385

Query: 272 CPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDA 331
           CP L  KPKLFFIQAC GE+          S   E+   NPE   T  Q+          
Sbjct: 386 CPRLAEKPKLFFIQACQGEE-------IQPSVSIEADALNPEQAPTSLQD---------- 428

Query: 332 ISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWA-HSEDLQSLLLRVANA 390
             S+P  +D  +  +T PG+VS+R  + GSWY+++L +  ++     ED+ S+L  V + 
Sbjct: 429 --SIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPRHEDILSILTAVNDD 486

Query: 391 VS----VKGIYKQMPGCFNFLRKKLFF 413
           VS     +G  KQMP     LRKKL F
Sbjct: 487 VSRRVDKQGTKKQMPQPAFTLRKKLVF 513


>gi|14916483 caspase 6 isoform alpha preproprotein [Homo sapiens]
          Length = 293

 Score =  115 bits (287), Expect = 1e-25
 Identities = 84/265 (31%), Positives = 124/265 (46%), Gaps = 33/265 (12%)

Query: 161 GHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELA 220
           G  LI N+  F     L  R G+  D + L RRFS L F V+   DL A++++L + E++
Sbjct: 45  GIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEELLLKIHEVS 104

Query: 221 QQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPK 280
              H   DC V V LSHG + +H      +Y  D   + ++ +  +F G  C SL GKPK
Sbjct: 105 TVSHADADCFVCVFLSHG-EGNH------IYAYD-AKIEIQTLTGLFKGDKCHSLVGKPK 156

Query: 281 LFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAIS--SLPTP 338
           +F IQAC G Q D         P D       + D            ++DA S  +LP  
Sbjct: 157 IFIIQACRGNQHD-----VPVIPLDVVDNQTEKLDT--------NITEVDAASVYTLPAG 203

Query: 339 SDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGI-- 396
           +D  + YS   G+ S R+  +GSWY++ L ++  ++  S +   LL  V   VS + +  
Sbjct: 204 ADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDF 263

Query: 397 --------YKQMPGCFNFLRKKLFF 413
                    KQ+P   + L KKL F
Sbjct: 264 CKDPSAIGKKQVPCFASMLTKKLHF 288


>gi|47078269 caspase 10 isoform b preproprotein [Homo sapiens]
          Length = 521

 Score =  108 bits (271), Expect = 7e-24
 Identities = 72/216 (33%), Positives = 108/216 (50%), Gaps = 30/216 (13%)

Query: 153 YILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKM 212
           Y ++    G C+I+NN +F   + L+ R G++ D E L   F  L F V +  ++T  +M
Sbjct: 276 YRMNRNHRGLCVIVNNHSF---TSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEM 332

Query: 213 VLALL-ELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTS 271
            + L  +     H   DC V  IL+HG      +F GAVY +D   + + +I++ F    
Sbjct: 333 EMVLQKQKCNPAHADGDCFVFCILTHG------RF-GAVYSSDEALIPIREIMSHFTALQ 385

Query: 272 CPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDA 331
           CP L  KPKLFFIQAC GE+          S   E+   NPE   T  Q+          
Sbjct: 386 CPRLAEKPKLFFIQACQGEE-------IQPSVSIEADALNPEQAPTSLQD---------- 428

Query: 332 ISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETL 367
             S+P  +D  +  +T PG+VS+R  + GSWY+++L
Sbjct: 429 --SIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSL 462


>gi|15431328 caspase 1 isoform alpha precursor [Homo sapiens]
          Length = 404

 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 100/406 (24%), Positives = 169/406 (41%), Gaps = 42/406 (10%)

Query: 10  RRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLIIDLETRGSQA 69
           R+  +R + E  ++ L D LL   +     +E ++R  + +  D+ R LI  +  +G+QA
Sbjct: 10  RKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENA-TVMDKTRALIDSVIPKGAQA 68

Query: 70  LPLFIS--CLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEVLRPETPR 127
             + I+  C ED+    LA  L  +      +   +++   V+       P+ ++     
Sbjct: 69  CQICITYICEEDS---YLAGTLGLSADQTSGNYLNMQDSQGVL--SSFPAPQAVQDNPAM 123

Query: 128 PVDIGSGGFGDVGALESLRG-----NADLAYILSMEPCGH-CLIINNVNFCRESGLRTRT 181
           P   GS G   + +LE  +      +A++  I+         LII N  F     +  RT
Sbjct: 124 PTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEF---DSIPRRT 180

Query: 182 GSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQ-DHGALDCCVVVILSHG-- 238
           G+ +D   +     +L + V+VK +LTA  M   L   A + +H   D   +V +SHG  
Sbjct: 181 GAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIR 240

Query: 239 ---CQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHG 295
              C   H +    +       + +  I N+ N  +CPSL  KPK+  IQAC G+     
Sbjct: 241 EGICGKKHSEQVPDI-------LQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPG-- 291

Query: 296 FEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWR 355
             V          G+   P    F++        DAI       D     S+ P  VSWR
Sbjct: 292 --VVWFKDSVGVSGNLSLPTTEEFED--------DAIKKAHIEKDFIAFCSSTPDNVSWR 341

Query: 356 DPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMP 401
            P  GS ++  L +  +++A S D++ +  +V  +        QMP
Sbjct: 342 HPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMP 387


>gi|6912286 caspase 14 precursor [Homo sapiens]
          Length = 242

 Score = 85.5 bits (210), Expect = 8e-17
 Identities = 72/244 (29%), Positives = 112/244 (45%), Gaps = 35/244 (14%)

Query: 178 RTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALD---CCVVVI 234
           + R GS  D + L   F  L F   +K D TA++    L +  Q      D   C  VV+
Sbjct: 27  KAREGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQQAIDSREDPVSCAFVVL 86

Query: 235 LSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDH 294
           ++HG +       G + G DG  V +E +    N  +C +L  KPK++ IQAC GEQ+D 
Sbjct: 87  MAHGRE-------GFLKGEDGEMVKLENLFEALNNKNCQALRAKPKVYIIQACRGEQRDP 139

Query: 295 GFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSW 354
           G  V      DE                       D+  ++PT +D    YST  G++++
Sbjct: 140 GETVGG----DEI-----------------VMVIKDSPQTIPTYTDALHVYSTVEGYIAY 178

Query: 355 RDPKSGSWYVETLDDIF-EQWAH-SEDLQSLLLRVANAVSVK--GIYKQMPGCFNFLRKK 410
           R  + GS +++TL D+F ++  H  E L  +  R+A A  V+     K  P   + LRK+
Sbjct: 179 RHDQKGSCFIQTLVDVFTKRKGHILELLTEVTRRMAEAELVQEGKARKTNPEIQSTLRKR 238

Query: 411 LFFK 414
           L+ +
Sbjct: 239 LYLQ 242


>gi|14916485 caspase 6 isoform beta [Homo sapiens]
          Length = 204

 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 62/202 (30%), Positives = 91/202 (45%), Gaps = 33/202 (16%)

Query: 224 HGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFF 283
           H   DC V V LSHG + +H      +Y  D   + ++ +  +F G  C SL GKPK+F 
Sbjct: 19  HADADCFVCVFLSHG-EGNH------IYAYDA-KIEIQTLTGLFKGDKCHSLVGKPKIFI 70

Query: 284 IQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAIS--SLPTPSDI 341
           IQAC G Q D         P D       + D            ++DA S  +LP  +D 
Sbjct: 71  IQACRGNQHD-----VPVIPLDVVDNQTEKLDT--------NITEVDAASVYTLPAGADF 117

Query: 342 FVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGI----- 396
            + YS   G+ S R+  +GSWY++ L ++  ++  S +   LL  V   VS + +     
Sbjct: 118 LMCYSVAEGYYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKD 177

Query: 397 -----YKQMPGCFNFLRKKLFF 413
                 KQ+P   + L KKL F
Sbjct: 178 PSAIGKKQVPCFASMLTKKLHF 199


>gi|4502573 caspase 1 isoform beta precursor [Homo sapiens]
          Length = 383

 Score = 83.2 bits (204), Expect = 4e-16
 Identities = 99/406 (24%), Positives = 163/406 (40%), Gaps = 63/406 (15%)

Query: 10  RRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLIIDLETRGSQA 69
           R+  +R + E  ++ L D LL   +     +E ++R  + +  D+ R LI  +  +G+QA
Sbjct: 10  RKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENA-TVMDKTRALIDSVIPKGAQA 68

Query: 70  LPLFIS--CLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEVLRPETPR 127
             + I+  C ED+    LA  L  +                         P+ ++     
Sbjct: 69  CQICITYICEEDS---YLAGTLGLSAA-----------------------PQAVQDNPAM 102

Query: 128 PVDIGSGGFGDVGALESLRG-----NADLAYILSMEPCGH-CLIINNVNFCRESGLRTRT 181
           P   GS G   + +LE  +      +A++  I+         LII N  F     +  RT
Sbjct: 103 PTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEF---DSIPRRT 159

Query: 182 GSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQ-DHGALDCCVVVILSHG-- 238
           G+ +D   +     +L + V+VK +LTA  M   L   A + +H   D   +V +SHG  
Sbjct: 160 GAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIR 219

Query: 239 ---CQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHG 295
              C   H +    +       + +  I N+ N  +CPSL  KPK+  IQAC G+     
Sbjct: 220 EGICGKKHSEQVPDI-------LQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPG-- 270

Query: 296 FEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWR 355
             V          G+   P    F++        DAI       D     S+ P  VSWR
Sbjct: 271 --VVWFKDSVGVSGNLSLPTTEEFED--------DAIKKAHIEKDFIAFCSSTPDNVSWR 320

Query: 356 DPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMP 401
            P  GS ++  L +  +++A S D++ +  +V  +        QMP
Sbjct: 321 HPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMP 366


>gi|15431330 caspase 1 isoform gamma precursor [Homo sapiens]
          Length = 311

 Score = 77.4 bits (189), Expect = 2e-14
 Identities = 78/316 (24%), Positives = 128/316 (40%), Gaps = 34/316 (10%)

Query: 98  LSKPTLENLTPVVLRPEIRKPEVLRPETPRPVDIGSGGFGDVGALESLRG-----NADLA 152
           ++   L+    + +R     P+ ++     P   GS G   + +LE  +      +A++ 
Sbjct: 1   MADKVLKEKRKLFIRSMGEAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIY 60

Query: 153 YILSMEPCGH-CLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKK 211
            I+         LII N  F     +  RTG+ +D   +     +L + V+VK +LTA  
Sbjct: 61  PIMDKSSRTRLALIICNEEF---DSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASD 117

Query: 212 MVLALLELAQQ-DHGALDCCVVVILSHG-----CQASHLQFPGAVYGTDGCPVSVEKIVN 265
           M   L   A + +H   D   +V +SHG     C   H +    +       + +  I N
Sbjct: 118 MTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDI-------LQLNAIFN 170

Query: 266 IFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRT 325
           + N  +CPSL  KPK+  IQAC G+       V          G+   P    F++    
Sbjct: 171 MLNTKNCPSLKDKPKVIIIQACRGDSPG----VVWFKDSVGVSGNLSLPTTEEFED---- 222

Query: 326 FDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLL 385
               DAI       D     S+ P  VSWR P  GS ++  L +  +++A S D++ +  
Sbjct: 223 ----DAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFR 278

Query: 386 RVANAVSVKGIYKQMP 401
           +V  +        QMP
Sbjct: 279 KVRFSFEQPDGRAQMP 294


>gi|15451910 caspase 4 isoform gamma precursor [Homo sapiens]
          Length = 321

 Score = 73.6 bits (179), Expect = 3e-13
 Identities = 67/240 (27%), Positives = 106/240 (44%), Gaps = 20/240 (8%)

Query: 164 LIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQ- 222
           LII N  F     L  R G++ D   ++     L + V+V+ +LTA+ M  AL   A + 
Sbjct: 83  LIICNTEF---DHLPPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRP 139

Query: 223 DHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSV-EKIVNIFNGTSCPSLGGKPKL 281
           +H + D   +V++SHG         G V+      V + + I  IFN  +C SL  KPK+
Sbjct: 140 EHKSSDSTFLVLMSHGILEG---ICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKV 196

Query: 282 FFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDI 341
             +QAC G  +   +         +SP S  E  ++   E L    + DA+       D 
Sbjct: 197 IIVQACRGANRGELW-------VRDSPAS-LEVASSQSSENL----EEDAVYKTHVEKDF 244

Query: 342 FVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMP 401
               S+ P  VSWRD   GS ++  L   F++++    L+ +  +V  +        QMP
Sbjct: 245 IAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMP 304


>gi|4502577 caspase 4 isoform alpha precursor [Homo sapiens]
          Length = 377

 Score = 73.6 bits (179), Expect = 3e-13
 Identities = 67/240 (27%), Positives = 106/240 (44%), Gaps = 20/240 (8%)

Query: 164 LIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQ- 222
           LII N  F     L  R G++ D   ++     L + V+V+ +LTA+ M  AL   A + 
Sbjct: 139 LIICNTEF---DHLPPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRP 195

Query: 223 DHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSV-EKIVNIFNGTSCPSLGGKPKL 281
           +H + D   +V++SHG         G V+      V + + I  IFN  +C SL  KPK+
Sbjct: 196 EHKSSDSTFLVLMSHGILEG---ICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKV 252

Query: 282 FFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDI 341
             +QAC G  +   +         +SP S  E  ++   E L    + DA+       D 
Sbjct: 253 IIVQACRGANRGELW-------VRDSPAS-LEVASSQSSENL----EEDAVYKTHVEKDF 300

Query: 342 FVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMP 401
               S+ P  VSWRD   GS ++  L   F++++    L+ +  +V  +        QMP
Sbjct: 301 IAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMP 360


>gi|209870079 caspase 5 isoform f precursor [Homo sapiens]
          Length = 447

 Score = 73.6 bits (179), Expect = 3e-13
 Identities = 66/244 (27%), Positives = 105/244 (43%), Gaps = 28/244 (11%)

Query: 164 LIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQ- 222
           LII N  F     L  R G++ D   ++R    L + V  + +LTA+ M   L   A + 
Sbjct: 209 LIICNTKF---DHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARP 265

Query: 223 DHGALDCCVVVILSHG-----CQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGG 277
           +H + D   +V++SHG     C  +H +    V       +  + I  IFN  +C SL  
Sbjct: 266 EHKSSDSTFLVLMSHGILEGICGTAHKKKKPDV-------LLYDTIFQIFNNRNCLSLKD 318

Query: 278 KPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPT 337
           KPK+  +QAC GE+  HG      SP   +  S+   +            + D++  +  
Sbjct: 319 KPKVIIVQACRGEK--HGELWVRDSPASLALISSQSSENL----------EADSVCKIHE 366

Query: 338 PSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIY 397
             D     S+ P  VSWRD   GS ++  L   F++++    L  +  +V  +  V    
Sbjct: 367 EKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAK 426

Query: 398 KQMP 401
            QMP
Sbjct: 427 AQMP 430


>gi|209870073 caspase 5 isoform c [Homo sapiens]
          Length = 292

 Score = 73.6 bits (179), Expect = 3e-13
 Identities = 66/244 (27%), Positives = 105/244 (43%), Gaps = 28/244 (11%)

Query: 164 LIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQ- 222
           LII N  F     L  R G++ D   ++R    L + V  + +LTA+ M   L   A + 
Sbjct: 54  LIICNTKF---DHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARP 110

Query: 223 DHGALDCCVVVILSHG-----CQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGG 277
           +H + D   +V++SHG     C  +H +    V       +  + I  IFN  +C SL  
Sbjct: 111 EHKSSDSTFLVLMSHGILEGICGTAHKKKKPDV-------LLYDTIFQIFNNRNCLSLKD 163

Query: 278 KPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPT 337
           KPK+  +QAC GE+  HG      SP   +  S+   +            + D++  +  
Sbjct: 164 KPKVIIVQACRGEK--HGELWVRDSPASLALISSQSSENL----------EADSVCKIHE 211

Query: 338 PSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIY 397
             D     S+ P  VSWRD   GS ++  L   F++++    L  +  +V  +  V    
Sbjct: 212 EKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAK 271

Query: 398 KQMP 401
            QMP
Sbjct: 272 AQMP 275


>gi|209870071 caspase 5 isoform b precursor [Homo sapiens]
          Length = 376

 Score = 73.6 bits (179), Expect = 3e-13
 Identities = 66/244 (27%), Positives = 105/244 (43%), Gaps = 28/244 (11%)

Query: 164 LIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQ- 222
           LII N  F     L  R G++ D   ++R    L + V  + +LTA+ M   L   A + 
Sbjct: 138 LIICNTKF---DHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARP 194

Query: 223 DHGALDCCVVVILSHG-----CQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGG 277
           +H + D   +V++SHG     C  +H +    V       +  + I  IFN  +C SL  
Sbjct: 195 EHKSSDSTFLVLMSHGILEGICGTAHKKKKPDV-------LLYDTIFQIFNNRNCLSLKD 247

Query: 278 KPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPT 337
           KPK+  +QAC GE+  HG      SP   +  S+   +            + D++  +  
Sbjct: 248 KPKVIIVQACRGEK--HGELWVRDSPASLALISSQSSENL----------EADSVCKIHE 295

Query: 338 PSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIY 397
             D     S+ P  VSWRD   GS ++  L   F++++    L  +  +V  +  V    
Sbjct: 296 EKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAK 355

Query: 398 KQMP 401
            QMP
Sbjct: 356 AQMP 359


>gi|209870069 caspase 5 isoform a precursor [Homo sapiens]
          Length = 434

 Score = 73.6 bits (179), Expect = 3e-13
 Identities = 66/244 (27%), Positives = 105/244 (43%), Gaps = 28/244 (11%)

Query: 164 LIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQ- 222
           LII N  F     L  R G++ D   ++R    L + V  + +LTA+ M   L   A + 
Sbjct: 196 LIICNTKF---DHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARP 252

Query: 223 DHGALDCCVVVILSHG-----CQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGG 277
           +H + D   +V++SHG     C  +H +    V       +  + I  IFN  +C SL  
Sbjct: 253 EHKSSDSTFLVLMSHGILEGICGTAHKKKKPDV-------LLYDTIFQIFNNRNCLSLKD 305

Query: 278 KPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPT 337
           KPK+  +QAC GE+  HG      SP   +  S+   +            + D++  +  
Sbjct: 306 KPKVIIVQACRGEK--HGELWVRDSPASLALISSQSSENL----------EADSVCKIHE 353

Query: 338 PSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIY 397
             D     S+ P  VSWRD   GS ++  L   F++++    L  +  +V  +  V    
Sbjct: 354 EKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAK 413

Query: 398 KQMP 401
            QMP
Sbjct: 414 AQMP 417


>gi|239756464 PREDICTED: hypothetical protein LOC197350 [Homo
           sapiens]
          Length = 432

 Score = 66.2 bits (160), Expect = 5e-11
 Identities = 62/224 (27%), Positives = 97/224 (43%), Gaps = 21/224 (9%)

Query: 177 LRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQ---DHGALDCCVVV 233
           ++ R G+  D E L     +L F   V+ D TA+     L +  +Q     G + C +V 
Sbjct: 189 IQGRPGAQHDVEALGGLCWALGFETTVRTDPTAQAFQEELAQFREQLDTCRGPVSCALVA 248

Query: 234 ILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKD 293
           +++HG         G + G DG  V  E ++   +   C  L G+PK+F +QAC G  +D
Sbjct: 249 LMAHGGPR------GQLLGADGQEVQPEALMQELS--RCQVLQGRPKIFLLQACRGGNRD 300

Query: 294 HGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTP------SDIFVSYST 347
            G  V  T+           P      + L+ + +    S   TP      +DI   YS 
Sbjct: 301 AG--VGPTALPWYWSWLRAPPSVPSHADVLQIYAEAQGSSCRGTPPGSSDQADILTVYSA 358

Query: 348 FPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAV 391
             G+V++RD K GS +++TL ++        DL  LL  V   V
Sbjct: 359 AEGYVAYRDDK-GSDFIQTLVEVLRA-NPGRDLLELLTEVNRRV 400


>gi|169210653 PREDICTED: hypothetical protein LOC197350 [Homo
           sapiens]
          Length = 432

 Score = 66.2 bits (160), Expect = 5e-11
 Identities = 62/224 (27%), Positives = 97/224 (43%), Gaps = 21/224 (9%)

Query: 177 LRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQ---DHGALDCCVVV 233
           ++ R G+  D E L     +L F   V+ D TA+     L +  +Q     G + C +V 
Sbjct: 189 IQGRPGAQHDVEALGGLCWALGFETTVRTDPTAQAFQEELAQFREQLDTCRGPVSCALVA 248

Query: 234 ILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKD 293
           +++HG         G + G DG  V  E ++   +   C  L G+PK+F +QAC G  +D
Sbjct: 249 LMAHGGPR------GQLLGADGQEVQPEALMQELS--RCQVLQGRPKIFLLQACRGGNRD 300

Query: 294 HGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTP------SDIFVSYST 347
            G  V  T+           P      + L+ + +    S   TP      +DI   YS 
Sbjct: 301 AG--VGPTALPWYWSWLRAPPSVPSHADVLQIYAEAQGSSCRGTPPGSSDQADILTVYSA 358

Query: 348 FPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAV 391
             G+V++RD K GS +++TL ++        DL  LL  V   V
Sbjct: 359 AEGYVAYRDDK-GSDFIQTLVEVLRA-NPGRDLLELLTEVNRRV 400


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.138    0.418 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,980,128
Number of Sequences: 37866
Number of extensions: 842478
Number of successful extensions: 2349
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 43
Number of HSP's successfully gapped in prelim test: 10
Number of HSP's that attempted gapping in prelim test: 2238
Number of HSP's gapped (non-prelim): 57
length of query: 416
length of database: 18,247,518
effective HSP length: 105
effective length of query: 311
effective length of database: 14,271,588
effective search space: 4438463868
effective search space used: 4438463868
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.