Guide to the Human Genome
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Search of human proteins with 14790119

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|14790119 caspase 3 preproprotein [Homo sapiens]
         (277 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|14790115 caspase 3 preproprotein [Homo sapiens]                    568   e-162
gi|14790119 caspase 3 preproprotein [Homo sapiens]                    568   e-162
gi|15718698 caspase 7 isoform delta [Homo sapiens]                    282   3e-76
gi|15718700 caspase 7 isoform alpha [Homo sapiens]                    282   3e-76
gi|4502581 caspase 7 isoform alpha precursor [Homo sapiens]           282   3e-76
gi|14916483 caspase 6 isoform alpha preproprotein [Homo sapiens]      204   9e-53
gi|14916485 caspase 6 isoform beta [Homo sapiens]                     162   2e-40
gi|122056476 caspase 8 isoform G precursor [Homo sapiens]             159   3e-39
gi|122056474 caspase 8 isoform C precursor [Homo sapiens]             159   3e-39
gi|15718708 caspase 8 isoform C precursor [Homo sapiens]              159   3e-39
gi|15718706 caspase 8 isoform B precursor [Homo sapiens]              159   3e-39
gi|15718704 caspase 8 isoform A precursor [Homo sapiens]              159   3e-39
gi|14790124 caspase 9 isoform alpha preproprotein [Homo sapiens]      155   4e-38
gi|47078272 caspase 10 isoform d preproprotein [Homo sapiens]         130   2e-30
gi|47078267 caspase 10 isoform a preproprotein [Homo sapiens]         130   2e-30
gi|39995059 caspase 2 isoform 1 preproprotein [Homo sapiens]          124   1e-28
gi|47078269 caspase 10 isoform b preproprotein [Homo sapiens]         121   6e-28
gi|6912286 caspase 14 precursor [Homo sapiens]                        102   4e-22
gi|15718702 caspase 7 isoform beta [Homo sapiens]                      92   6e-19
gi|15451910 caspase 4 isoform gamma precursor [Homo sapiens]           89   5e-18
gi|4502577 caspase 4 isoform alpha precursor [Homo sapiens]            89   5e-18
gi|209870079 caspase 5 isoform f precursor [Homo sapiens]              83   3e-16
gi|209870073 caspase 5 isoform c [Homo sapiens]                        83   3e-16
gi|209870071 caspase 5 isoform b precursor [Homo sapiens]              83   3e-16
gi|209870069 caspase 5 isoform a precursor [Homo sapiens]              83   3e-16
gi|15431330 caspase 1 isoform gamma precursor [Homo sapiens]           80   2e-15
gi|15431328 caspase 1 isoform alpha precursor [Homo sapiens]           80   2e-15
gi|4502573 caspase 1 isoform beta precursor [Homo sapiens]             80   2e-15
gi|209870075 caspase 5 isoform d [Homo sapiens]                        74   1e-13
gi|187608577 CASP8 and FADD-like apoptosis regulator isoform 1 [...    66   4e-11

>gi|14790115 caspase 3 preproprotein [Homo sapiens]
          Length = 277

 Score =  568 bits (1463), Expect = e-162
 Identities = 277/277 (100%), Positives = 277/277 (100%)

Query: 1   MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTG 60
           MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTG
Sbjct: 1   MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTG 60

Query: 61  MTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLS 120
           MTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLS
Sbjct: 61  MTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLS 120

Query: 121 HGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDD 180
           HGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDD
Sbjct: 121 HGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDD 180

Query: 181 DMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVN 240
           DMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVN
Sbjct: 181 DMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVN 240

Query: 241 RKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH 277
           RKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
Sbjct: 241 RKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH 277


>gi|14790119 caspase 3 preproprotein [Homo sapiens]
          Length = 277

 Score =  568 bits (1463), Expect = e-162
 Identities = 277/277 (100%), Positives = 277/277 (100%)

Query: 1   MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTG 60
           MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTG
Sbjct: 1   MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTG 60

Query: 61  MTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLS 120
           MTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLS
Sbjct: 61  MTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLS 120

Query: 121 HGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDD 180
           HGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDD
Sbjct: 121 HGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDD 180

Query: 181 DMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVN 240
           DMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVN
Sbjct: 181 DMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVN 240

Query: 241 RKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH 277
           RKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
Sbjct: 241 RKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH 277


>gi|15718698 caspase 7 isoform delta [Homo sapiens]
          Length = 336

 Score =  282 bits (721), Expect = 3e-76
 Identities = 138/242 (57%), Positives = 178/242 (73%), Gaps = 3/242 (1%)

Query: 37  YKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEI 96
           Y M++ ++G CIIINNKNF K TGM  R+GTD DA  L + FR+L ++V   ND +  ++
Sbjct: 93  YNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKM 152

Query: 97  VELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPK 156
            +L++  S+EDH+  + F C+LLSHGEE +I+G +G   +K +T  FRGDRC++L  KPK
Sbjct: 153 QDLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPK 212

Query: 157 LFIIQACRGTELDCGIETDSGVDDDMAC---HKIPVEADFLYAYSTAPGYYSWRNSKDGS 213
           LF IQACRGTELD GI+ DSG  +D      +KIPVEADFL+AYST PGYYSWR+   GS
Sbjct: 213 LFFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGS 272

Query: 214 WFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKEL 273
           WF+Q+LC++L+++   LE M ILTRVN +VA  FES S D  FH KKQIPC+VSMLTKEL
Sbjct: 273 WFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKEL 332

Query: 274 YF 275
           YF
Sbjct: 333 YF 334


>gi|15718700 caspase 7 isoform alpha [Homo sapiens]
          Length = 303

 Score =  282 bits (721), Expect = 3e-76
 Identities = 138/242 (57%), Positives = 178/242 (73%), Gaps = 3/242 (1%)

Query: 37  YKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEI 96
           Y M++ ++G CIIINNKNF K TGM  R+GTD DA  L + FR+L ++V   ND +  ++
Sbjct: 60  YNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKM 119

Query: 97  VELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPK 156
            +L++  S+EDH+  + F C+LLSHGEE +I+G +G   +K +T  FRGDRC++L  KPK
Sbjct: 120 QDLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPK 179

Query: 157 LFIIQACRGTELDCGIETDSGVDDDMAC---HKIPVEADFLYAYSTAPGYYSWRNSKDGS 213
           LF IQACRGTELD GI+ DSG  +D      +KIPVEADFL+AYST PGYYSWR+   GS
Sbjct: 180 LFFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGS 239

Query: 214 WFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKEL 273
           WF+Q+LC++L+++   LE M ILTRVN +VA  FES S D  FH KKQIPC+VSMLTKEL
Sbjct: 240 WFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKEL 299

Query: 274 YF 275
           YF
Sbjct: 300 YF 301


>gi|4502581 caspase 7 isoform alpha precursor [Homo sapiens]
          Length = 303

 Score =  282 bits (721), Expect = 3e-76
 Identities = 138/242 (57%), Positives = 178/242 (73%), Gaps = 3/242 (1%)

Query: 37  YKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEI 96
           Y M++ ++G CIIINNKNF K TGM  R+GTD DA  L + FR+L ++V   ND +  ++
Sbjct: 60  YNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKM 119

Query: 97  VELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPK 156
            +L++  S+EDH+  + F C+LLSHGEE +I+G +G   +K +T  FRGDRC++L  KPK
Sbjct: 120 QDLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPK 179

Query: 157 LFIIQACRGTELDCGIETDSGVDDDMAC---HKIPVEADFLYAYSTAPGYYSWRNSKDGS 213
           LF IQACRGTELD GI+ DSG  +D      +KIPVEADFL+AYST PGYYSWR+   GS
Sbjct: 180 LFFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGS 239

Query: 214 WFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKEL 273
           WF+Q+LC++L+++   LE M ILTRVN +VA  FES S D  FH KKQIPC+VSMLTKEL
Sbjct: 240 WFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKEL 299

Query: 274 YF 275
           YF
Sbjct: 300 YF 301


>gi|14916483 caspase 6 isoform alpha preproprotein [Homo sapiens]
          Length = 293

 Score =  204 bits (518), Expect = 9e-53
 Identities = 105/253 (41%), Positives = 147/253 (58%), Gaps = 13/253 (5%)

Query: 37  YKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEI 96
           YKMD+   G+ +I N++ F     +  R GT  D  NL   F +L +EV+  NDL  EE+
Sbjct: 37  YKMDHRRRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEEL 96

Query: 97  VELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPK 156
           +  + +VS   H+    FVCV LSHGE   I+  +  ++++ +T  F+GD+C SL GKPK
Sbjct: 97  LLKIHEVSTVSHADADCFVCVFLSHGEGNHIYAYDAKIEIQTLTGLFKGDKCHSLVGKPK 156

Query: 157 LFIIQACRGTELDCGI-------------ETDSGVDDDMACHKIPVEADFLYAYSTAPGY 203
           +FIIQACRG + D  +             +T+    D  + + +P  ADFL  YS A GY
Sbjct: 157 IFIIQACRGNQHDVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMCYSVAEGY 216

Query: 204 YSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIP 263
           YS R + +GSW+IQ LC ML +Y   LEF  +LT VNRKV+     F  D +   KKQ+P
Sbjct: 217 YSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQVP 276

Query: 264 CIVSMLTKELYFY 276
           C  SMLTK+L+F+
Sbjct: 277 CFASMLTKKLHFF 289


>gi|14916485 caspase 6 isoform beta [Homo sapiens]
          Length = 204

 Score =  162 bits (411), Expect = 2e-40
 Identities = 83/187 (44%), Positives = 110/187 (58%), Gaps = 13/187 (6%)

Query: 103 VSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQA 162
           VS   H+    FVCV LSHGE   I+  +  ++++ +T  F+GD+C SL GKPK+FIIQA
Sbjct: 14  VSTVSHADADCFVCVFLSHGEGNHIYAYDAKIEIQTLTGLFKGDKCHSLVGKPKIFIIQA 73

Query: 163 CRGTELDCGIETDSGVD-------------DDMACHKIPVEADFLYAYSTAPGYYSWRNS 209
           CRG + D  +     VD             D  + + +P  ADFL  YS A GYYS R +
Sbjct: 74  CRGNQHDVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMCYSVAEGYYSHRET 133

Query: 210 KDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSML 269
            +GSW+IQ LC ML +Y   LEF  +LT VNRKV+     F  D +   KKQ+PC  SML
Sbjct: 134 VNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQVPCFASML 193

Query: 270 TKELYFY 276
           TK+L+F+
Sbjct: 194 TKKLHFF 200


>gi|122056476 caspase 8 isoform G precursor [Homo sapiens]
          Length = 538

 Score =  159 bits (401), Expect = 3e-39
 Identities = 99/262 (37%), Positives = 148/262 (56%), Gaps = 24/262 (9%)

Query: 32  SLDNSYKMDYPEMGLCIIINNKNFHKST-------GMTSRSGTDVDAANLRETFRNLKYE 84
           +LD  Y+M     G C+IINN NF K+         +  R+GT +DA  L  TF  L +E
Sbjct: 280 TLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE 339

Query: 85  VRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNG-PVDLKKITNFF 143
           ++  +D T E+I E+++     DHS    F+C +LSHG++GII+GT+G    + ++T+ F
Sbjct: 340 IKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQF 399

Query: 144 RGDRCRSLTGKPKLFIIQACRGTELDCGI--ETDSG----VDDDMACHK---IPVEADFL 194
            G +C SL GKPK+F IQAC+G     GI  ETDS     ++ D++  +   IP EADFL
Sbjct: 400 TGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFL 459

Query: 195 YAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADK-LEFMHILTRVNRKVATEFESFSFD 253
              +T     S+RN  +G+W+IQSLC  L++   +  + + ILT VN +V+ +      D
Sbjct: 460 LGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNK------D 513

Query: 254 ATFHAKKQIPCIVSMLTKELYF 275
              +  KQ+P     L K+L F
Sbjct: 514 DKKNMGKQMPQPTFTLRKKLVF 535


>gi|122056474 caspase 8 isoform C precursor [Homo sapiens]
          Length = 464

 Score =  159 bits (401), Expect = 3e-39
 Identities = 99/262 (37%), Positives = 148/262 (56%), Gaps = 24/262 (9%)

Query: 32  SLDNSYKMDYPEMGLCIIINNKNFHKST-------GMTSRSGTDVDAANLRETFRNLKYE 84
           +LD  Y+M     G C+IINN NF K+         +  R+GT +DA  L  TF  L +E
Sbjct: 206 TLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE 265

Query: 85  VRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNG-PVDLKKITNFF 143
           ++  +D T E+I E+++     DHS    F+C +LSHG++GII+GT+G    + ++T+ F
Sbjct: 266 IKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQF 325

Query: 144 RGDRCRSLTGKPKLFIIQACRGTELDCGI--ETDSG----VDDDMACHK---IPVEADFL 194
            G +C SL GKPK+F IQAC+G     GI  ETDS     ++ D++  +   IP EADFL
Sbjct: 326 TGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFL 385

Query: 195 YAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADK-LEFMHILTRVNRKVATEFESFSFD 253
              +T     S+RN  +G+W+IQSLC  L++   +  + + ILT VN +V+ +      D
Sbjct: 386 LGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNK------D 439

Query: 254 ATFHAKKQIPCIVSMLTKELYF 275
              +  KQ+P     L K+L F
Sbjct: 440 DKKNMGKQMPQPTFTLRKKLVF 461


>gi|15718708 caspase 8 isoform C precursor [Homo sapiens]
          Length = 464

 Score =  159 bits (401), Expect = 3e-39
 Identities = 99/262 (37%), Positives = 148/262 (56%), Gaps = 24/262 (9%)

Query: 32  SLDNSYKMDYPEMGLCIIINNKNFHKST-------GMTSRSGTDVDAANLRETFRNLKYE 84
           +LD  Y+M     G C+IINN NF K+         +  R+GT +DA  L  TF  L +E
Sbjct: 206 TLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE 265

Query: 85  VRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNG-PVDLKKITNFF 143
           ++  +D T E+I E+++     DHS    F+C +LSHG++GII+GT+G    + ++T+ F
Sbjct: 266 IKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQF 325

Query: 144 RGDRCRSLTGKPKLFIIQACRGTELDCGI--ETDSG----VDDDMACHK---IPVEADFL 194
            G +C SL GKPK+F IQAC+G     GI  ETDS     ++ D++  +   IP EADFL
Sbjct: 326 TGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFL 385

Query: 195 YAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADK-LEFMHILTRVNRKVATEFESFSFD 253
              +T     S+RN  +G+W+IQSLC  L++   +  + + ILT VN +V+ +      D
Sbjct: 386 LGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNK------D 439

Query: 254 ATFHAKKQIPCIVSMLTKELYF 275
              +  KQ+P     L K+L F
Sbjct: 440 DKKNMGKQMPQPTFTLRKKLVF 461


>gi|15718706 caspase 8 isoform B precursor [Homo sapiens]
          Length = 479

 Score =  159 bits (401), Expect = 3e-39
 Identities = 99/262 (37%), Positives = 148/262 (56%), Gaps = 24/262 (9%)

Query: 32  SLDNSYKMDYPEMGLCIIINNKNFHKST-------GMTSRSGTDVDAANLRETFRNLKYE 84
           +LD  Y+M     G C+IINN NF K+         +  R+GT +DA  L  TF  L +E
Sbjct: 221 TLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE 280

Query: 85  VRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNG-PVDLKKITNFF 143
           ++  +D T E+I E+++     DHS    F+C +LSHG++GII+GT+G    + ++T+ F
Sbjct: 281 IKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQF 340

Query: 144 RGDRCRSLTGKPKLFIIQACRGTELDCGI--ETDSG----VDDDMACHK---IPVEADFL 194
            G +C SL GKPK+F IQAC+G     GI  ETDS     ++ D++  +   IP EADFL
Sbjct: 341 TGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFL 400

Query: 195 YAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADK-LEFMHILTRVNRKVATEFESFSFD 253
              +T     S+RN  +G+W+IQSLC  L++   +  + + ILT VN +V+ +      D
Sbjct: 401 LGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNK------D 454

Query: 254 ATFHAKKQIPCIVSMLTKELYF 275
              +  KQ+P     L K+L F
Sbjct: 455 DKKNMGKQMPQPTFTLRKKLVF 476


>gi|15718704 caspase 8 isoform A precursor [Homo sapiens]
          Length = 496

 Score =  159 bits (401), Expect = 3e-39
 Identities = 99/262 (37%), Positives = 148/262 (56%), Gaps = 24/262 (9%)

Query: 32  SLDNSYKMDYPEMGLCIIINNKNFHKST-------GMTSRSGTDVDAANLRETFRNLKYE 84
           +LD  Y+M     G C+IINN NF K+         +  R+GT +DA  L  TF  L +E
Sbjct: 238 TLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE 297

Query: 85  VRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNG-PVDLKKITNFF 143
           ++  +D T E+I E+++     DHS    F+C +LSHG++GII+GT+G    + ++T+ F
Sbjct: 298 IKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQF 357

Query: 144 RGDRCRSLTGKPKLFIIQACRGTELDCGI--ETDSG----VDDDMACHK---IPVEADFL 194
            G +C SL GKPK+F IQAC+G     GI  ETDS     ++ D++  +   IP EADFL
Sbjct: 358 TGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFL 417

Query: 195 YAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADK-LEFMHILTRVNRKVATEFESFSFD 253
              +T     S+RN  +G+W+IQSLC  L++   +  + + ILT VN +V+ +      D
Sbjct: 418 LGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNK------D 471

Query: 254 ATFHAKKQIPCIVSMLTKELYF 275
              +  KQ+P     L K+L F
Sbjct: 472 DKKNMGKQMPQPTFTLRKKLVF 493


>gi|14790124 caspase 9 isoform alpha preproprotein [Homo sapiens]
          Length = 416

 Score =  155 bits (392), Expect = 4e-38
 Identities = 91/274 (33%), Positives = 142/274 (51%), Gaps = 42/274 (15%)

Query: 34  DNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTR 93
           D +Y +     G C+IINN NF + +G+ +R+G+++D   LR  F +L + V  K DLT 
Sbjct: 150 DLAYILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTA 209

Query: 94  EEIVELMRDVSKEDHSKRSSFVCVLLSHGEE-------GIIFGTNG-PVDLKKITNFFRG 145
           +++V  + +++++DH      V V+LSHG +       G ++GT+G PV ++KI N F G
Sbjct: 210 KKMVLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNG 269

Query: 146 DRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDM----------------------- 182
             C SL GKPKLF IQAC G + D G E  S   +D                        
Sbjct: 270 TSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQL 329

Query: 183 -ACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNR 241
            A   +P  +D   +YST PG+ SWR+ K GSW++++L  + +Q+A   +   +L RV  
Sbjct: 330 DAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVAN 389

Query: 242 KVATEFESFSFDATFHAKKQIPCIVSMLTKELYF 275
            V+ +             KQ+P   + L K+L+F
Sbjct: 390 AVSVK----------GIYKQMPGCFNFLRKKLFF 413


>gi|47078272 caspase 10 isoform d preproprotein [Homo sapiens]
          Length = 522

 Score =  130 bits (326), Expect = 2e-30
 Identities = 84/247 (34%), Positives = 132/247 (53%), Gaps = 17/247 (6%)

Query: 37  YKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEI 96
           Y+M+    GLC+I+NN +F   T +  R GT  DA  L   F+ L + V   N++T+ E+
Sbjct: 276 YRMNRNHRGLCVIVNNHSF---TSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEM 332

Query: 97  -VELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGP-VDLKKITNFFRGDRCRSLTGK 154
            + L +      H+    FV  +L+HG  G ++ ++   + +++I + F   +C  L  K
Sbjct: 333 EMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDEALIPIREIMSHFTALQCPRLAEK 392

Query: 155 PKLFIIQACRGTELDCGIETDS-GVDDDMAC----HKIPVEADFLYAYSTAPGYYSWRNS 209
           PKLF IQAC+G E+   +  ++  ++ + A       IP EADFL   +T PGY S+R+ 
Sbjct: 393 PKLFFIQACQGEEIQPSVSIEADALNPEQAPTSLQDSIPAEADFLLGLATVPGYVSFRHV 452

Query: 210 KDGSWFIQSLCAMLKQYADKLE-FMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSM 268
           ++GSW+IQSLC  LK+   + E  + ILT VN  V+   +          KKQ+P     
Sbjct: 453 EEGSWYIQSLCNHLKKLVPRHEDILSILTAVNDDVSRRVDKQG------TKKQMPQPAFT 506

Query: 269 LTKELYF 275
           L K+L F
Sbjct: 507 LRKKLVF 513


>gi|47078267 caspase 10 isoform a preproprotein [Homo sapiens]
          Length = 479

 Score =  130 bits (326), Expect = 2e-30
 Identities = 84/247 (34%), Positives = 132/247 (53%), Gaps = 17/247 (6%)

Query: 37  YKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEI 96
           Y+M+    GLC+I+NN +F   T +  R GT  DA  L   F+ L + V   N++T+ E+
Sbjct: 233 YRMNRNHRGLCVIVNNHSF---TSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEM 289

Query: 97  -VELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGP-VDLKKITNFFRGDRCRSLTGK 154
            + L +      H+    FV  +L+HG  G ++ ++   + +++I + F   +C  L  K
Sbjct: 290 EMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDEALIPIREIMSHFTALQCPRLAEK 349

Query: 155 PKLFIIQACRGTELDCGIETDS-GVDDDMAC----HKIPVEADFLYAYSTAPGYYSWRNS 209
           PKLF IQAC+G E+   +  ++  ++ + A       IP EADFL   +T PGY S+R+ 
Sbjct: 350 PKLFFIQACQGEEIQPSVSIEADALNPEQAPTSLQDSIPAEADFLLGLATVPGYVSFRHV 409

Query: 210 KDGSWFIQSLCAMLKQYADKLE-FMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSM 268
           ++GSW+IQSLC  LK+   + E  + ILT VN  V+   +          KKQ+P     
Sbjct: 410 EEGSWYIQSLCNHLKKLVPRHEDILSILTAVNDDVSRRVDKQG------TKKQMPQPAFT 463

Query: 269 LTKELYF 275
           L K+L F
Sbjct: 464 LRKKLVF 470


>gi|39995059 caspase 2 isoform 1 preproprotein [Homo sapiens]
          Length = 452

 Score =  124 bits (310), Expect = 1e-28
 Identities = 75/257 (29%), Positives = 130/257 (50%), Gaps = 17/257 (6%)

Query: 36  SYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREE 95
           +Y++     GL ++++N +F     +  RSG DVD + L   F+ L Y+V    D T +E
Sbjct: 191 AYRLQSRPRGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQE 250

Query: 96  IVELMRDVSK-EDHSKRSSFVCVLLSHGEEGIIFGTNGPV-DLKKITNFFRGDRCRSLTG 153
           + E +++ ++   H    S +  LLSHG EG I+G +G +  L+++   F    C SL  
Sbjct: 251 MQEKLQNFAQLPAHRVTDSCIVALLSHGVEGAIYGVDGKLLQLQEVFQLFDNANCPSLQN 310

Query: 154 KPKLFIIQACRGTELDCGIETDSGVD--------------DDMACHKIPVEADFLYAYST 199
           KPK+F IQACRG E D G++   G +              + +   ++P  +D +  Y+ 
Sbjct: 311 KPKMFFIQACRGDETDRGVDQQDGKNHAGSPGCEESDAGKEKLPKMRLPTRSDMICGYAC 370

Query: 200 APGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAK 259
             G  + RN+K GSW+I++L  +  + A  +    +L +VN  +  + E ++    FH  
Sbjct: 371 LKGTAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVNALI-KDREGYAPGTEFHRC 429

Query: 260 KQIPCIVSMLTKELYFY 276
           K++    S L + LY +
Sbjct: 430 KEMSEYCSTLCRHLYLF 446


>gi|47078269 caspase 10 isoform b preproprotein [Homo sapiens]
          Length = 521

 Score =  121 bits (304), Expect = 6e-28
 Identities = 74/227 (32%), Positives = 123/227 (54%), Gaps = 11/227 (4%)

Query: 37  YKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEI 96
           Y+M+    GLC+I+NN +F   T +  R GT  DA  L   F+ L + V   N++T+ E+
Sbjct: 276 YRMNRNHRGLCVIVNNHSF---TSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEM 332

Query: 97  -VELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGP-VDLKKITNFFRGDRCRSLTGK 154
            + L +      H+    FV  +L+HG  G ++ ++   + +++I + F   +C  L  K
Sbjct: 333 EMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDEALIPIREIMSHFTALQCPRLAEK 392

Query: 155 PKLFIIQACRGTELDCGIETDS-GVDDDMAC----HKIPVEADFLYAYSTAPGYYSWRNS 209
           PKLF IQAC+G E+   +  ++  ++ + A       IP EADFL   +T PGY S+R+ 
Sbjct: 393 PKLFFIQACQGEEIQPSVSIEADALNPEQAPTSLQDSIPAEADFLLGLATVPGYVSFRHV 452

Query: 210 KDGSWFIQSLCAMLKQYADK-LEFMHILTRVNRKVATEFESFSFDAT 255
           ++GSW+IQSLC  LK+   + L+F+     +  +  T + +    AT
Sbjct: 453 EEGSWYIQSLCNHLKKLVPRMLKFLEKTMEIRGRKRTVWGAKQISAT 499


>gi|6912286 caspase 14 precursor [Homo sapiens]
          Length = 242

 Score =  102 bits (254), Expect = 4e-22
 Identities = 74/220 (33%), Positives = 108/220 (49%), Gaps = 15/220 (6%)

Query: 63  SRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVC---VLL 119
           +R G++ D   L   FR L++E   K D T E+  E +    +   S+     C   VL+
Sbjct: 28  AREGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQQAIDSREDPVSCAFVVLM 87

Query: 120 SHGEEGIIFGTNGP-VDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGV 178
           +HG EG + G +G  V L+ +        C++L  KPK++IIQACRG + D G ET  G 
Sbjct: 88  AHGREGFLKGEDGEMVKLENLFEALNNKNCQALRAKPKVYIIQACRGEQRDPG-ETVGGD 146

Query: 179 DDDMAC----HKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMH 234
           +  M        IP   D L+ YST  GY ++R+ + GS FIQ+L  +  +   K   + 
Sbjct: 147 EIVMVIKDSPQTIPTYTDALHVYSTVEGYIAYRHDQKGSCFIQTLVDVFTK--RKGHILE 204

Query: 235 ILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELY 274
           +LT V R++A             A+K  P I S L K LY
Sbjct: 205 LLTEVTRRMA----EAELVQEGKARKTNPEIQSTLRKRLY 240


>gi|15718702 caspase 7 isoform beta [Homo sapiens]
          Length = 253

 Score = 91.7 bits (226), Expect = 6e-19
 Identities = 43/90 (47%), Positives = 63/90 (70%)

Query: 37  YKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEI 96
           Y M++ ++G CIIINNKNF K TGM  R+GTD DA  L + FR+L ++V   ND +  ++
Sbjct: 60  YNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKM 119

Query: 97  VELMRDVSKEDHSKRSSFVCVLLSHGEEGI 126
            +L++  S+EDH+  + F C+LLSHGEE +
Sbjct: 120 QDLLKKASEEDHTNAACFACILLSHGEENM 149


>gi|15451910 caspase 4 isoform gamma precursor [Homo sapiens]
          Length = 321

 Score = 88.6 bits (218), Expect = 5e-18
 Identities = 81/253 (32%), Positives = 111/253 (43%), Gaps = 39/253 (15%)

Query: 46  LCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRD-VS 104
           L +II N  F     +  R+G D D   ++E    L Y V  + +LT  ++   +R   +
Sbjct: 81  LALIICNTEFDH---LPPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFAT 137

Query: 105 KEDHSKRSSFVCVLLSHGEEGIIFGTNGPV-DLKK--------ITNFFRGDRCRSLTGKP 155
           + +H    S   VL+SHG   I+ G  G V D KK        I   F    C SL  KP
Sbjct: 138 RPEHKSSDSTFLVLMSHG---ILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKP 194

Query: 156 KLFIIQACRGTE------------LDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGY 203
           K+ I+QACRG              L+      S   ++ A +K  VE DF+   S+ P  
Sbjct: 195 KVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHN 254

Query: 204 YSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIP 263
            SWR+S  GS FI  L    ++Y+    +   L  V RKV   FE      T  AK Q+P
Sbjct: 255 VSWRDSTMGSIFITQLITCFQKYS----WCCHLEEVFRKVQQSFE------TPRAKAQMP 304

Query: 264 CIVSMLTKELYFY 276
            I   L+   YFY
Sbjct: 305 TI-ERLSMTRYFY 316


>gi|4502577 caspase 4 isoform alpha precursor [Homo sapiens]
          Length = 377

 Score = 88.6 bits (218), Expect = 5e-18
 Identities = 81/253 (32%), Positives = 111/253 (43%), Gaps = 39/253 (15%)

Query: 46  LCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRD-VS 104
           L +II N  F     +  R+G D D   ++E    L Y V  + +LT  ++   +R   +
Sbjct: 137 LALIICNTEFDH---LPPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFAT 193

Query: 105 KEDHSKRSSFVCVLLSHGEEGIIFGTNGPV-DLKK--------ITNFFRGDRCRSLTGKP 155
           + +H    S   VL+SHG   I+ G  G V D KK        I   F    C SL  KP
Sbjct: 194 RPEHKSSDSTFLVLMSHG---ILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKP 250

Query: 156 KLFIIQACRGTE------------LDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGY 203
           K+ I+QACRG              L+      S   ++ A +K  VE DF+   S+ P  
Sbjct: 251 KVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHN 310

Query: 204 YSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIP 263
            SWR+S  GS FI  L    ++Y+    +   L  V RKV   FE      T  AK Q+P
Sbjct: 311 VSWRDSTMGSIFITQLITCFQKYS----WCCHLEEVFRKVQQSFE------TPRAKAQMP 360

Query: 264 CIVSMLTKELYFY 276
            I   L+   YFY
Sbjct: 361 TI-ERLSMTRYFY 372


>gi|209870079 caspase 5 isoform f precursor [Homo sapiens]
          Length = 447

 Score = 82.8 bits (203), Expect = 3e-16
 Identities = 73/255 (28%), Positives = 110/255 (43%), Gaps = 41/255 (16%)

Query: 46  LCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRD-VS 104
           L +II N  F     + +R+G   D   ++   + L Y V ++ +LT  ++  ++R   +
Sbjct: 207 LALIICNTKFDH---LPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAA 263

Query: 105 KEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKK---------ITNFFRGDRCRSLTGKP 155
           + +H    S   VL+SHG   I+ G  G    KK         I   F    C SL  KP
Sbjct: 264 RPEHKSSDSTFLVLMSHG---ILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKP 320

Query: 156 KLFIIQACRGTELD-------------CGIETDSGVDDDMACHKIPVEADFLYAYSTAPG 202
           K+ I+QACRG +                  ++   ++ D  C KI  E DF+   S+ P 
Sbjct: 321 KVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVC-KIHEEKDFIAFCSSTPH 379

Query: 203 YYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQI 262
             SWR+   GS FI  L    ++Y+     M I     RKV   FE         AK Q+
Sbjct: 380 NVSWRDRTRGSIFITELITCFQKYSCCCHLMEIF----RKVQKSFE------VPQAKAQM 429

Query: 263 PCIV-SMLTKELYFY 276
           P I  + LT++ Y +
Sbjct: 430 PTIERATLTRDFYLF 444


>gi|209870073 caspase 5 isoform c [Homo sapiens]
          Length = 292

 Score = 82.8 bits (203), Expect = 3e-16
 Identities = 73/255 (28%), Positives = 110/255 (43%), Gaps = 41/255 (16%)

Query: 46  LCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRD-VS 104
           L +II N  F     + +R+G   D   ++   + L Y V ++ +LT  ++  ++R   +
Sbjct: 52  LALIICNTKFDH---LPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAA 108

Query: 105 KEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKK---------ITNFFRGDRCRSLTGKP 155
           + +H    S   VL+SHG   I+ G  G    KK         I   F    C SL  KP
Sbjct: 109 RPEHKSSDSTFLVLMSHG---ILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKP 165

Query: 156 KLFIIQACRGTELD-------------CGIETDSGVDDDMACHKIPVEADFLYAYSTAPG 202
           K+ I+QACRG +                  ++   ++ D  C KI  E DF+   S+ P 
Sbjct: 166 KVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVC-KIHEEKDFIAFCSSTPH 224

Query: 203 YYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQI 262
             SWR+   GS FI  L    ++Y+     M I     RKV   FE         AK Q+
Sbjct: 225 NVSWRDRTRGSIFITELITCFQKYSCCCHLMEIF----RKVQKSFE------VPQAKAQM 274

Query: 263 PCIV-SMLTKELYFY 276
           P I  + LT++ Y +
Sbjct: 275 PTIERATLTRDFYLF 289


>gi|209870071 caspase 5 isoform b precursor [Homo sapiens]
          Length = 376

 Score = 82.8 bits (203), Expect = 3e-16
 Identities = 73/255 (28%), Positives = 110/255 (43%), Gaps = 41/255 (16%)

Query: 46  LCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRD-VS 104
           L +II N  F     + +R+G   D   ++   + L Y V ++ +LT  ++  ++R   +
Sbjct: 136 LALIICNTKFDH---LPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAA 192

Query: 105 KEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKK---------ITNFFRGDRCRSLTGKP 155
           + +H    S   VL+SHG   I+ G  G    KK         I   F    C SL  KP
Sbjct: 193 RPEHKSSDSTFLVLMSHG---ILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKP 249

Query: 156 KLFIIQACRGTELD-------------CGIETDSGVDDDMACHKIPVEADFLYAYSTAPG 202
           K+ I+QACRG +                  ++   ++ D  C KI  E DF+   S+ P 
Sbjct: 250 KVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVC-KIHEEKDFIAFCSSTPH 308

Query: 203 YYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQI 262
             SWR+   GS FI  L    ++Y+     M I     RKV   FE         AK Q+
Sbjct: 309 NVSWRDRTRGSIFITELITCFQKYSCCCHLMEIF----RKVQKSFE------VPQAKAQM 358

Query: 263 PCIV-SMLTKELYFY 276
           P I  + LT++ Y +
Sbjct: 359 PTIERATLTRDFYLF 373


>gi|209870069 caspase 5 isoform a precursor [Homo sapiens]
          Length = 434

 Score = 82.8 bits (203), Expect = 3e-16
 Identities = 73/255 (28%), Positives = 110/255 (43%), Gaps = 41/255 (16%)

Query: 46  LCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRD-VS 104
           L +II N  F     + +R+G   D   ++   + L Y V ++ +LT  ++  ++R   +
Sbjct: 194 LALIICNTKFDH---LPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAA 250

Query: 105 KEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKK---------ITNFFRGDRCRSLTGKP 155
           + +H    S   VL+SHG   I+ G  G    KK         I   F    C SL  KP
Sbjct: 251 RPEHKSSDSTFLVLMSHG---ILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKP 307

Query: 156 KLFIIQACRGTELD-------------CGIETDSGVDDDMACHKIPVEADFLYAYSTAPG 202
           K+ I+QACRG +                  ++   ++ D  C KI  E DF+   S+ P 
Sbjct: 308 KVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVC-KIHEEKDFIAFCSSTPH 366

Query: 203 YYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQI 262
             SWR+   GS FI  L    ++Y+     M I     RKV   FE         AK Q+
Sbjct: 367 NVSWRDRTRGSIFITELITCFQKYSCCCHLMEIF----RKVQKSFE------VPQAKAQM 416

Query: 263 PCIV-SMLTKELYFY 276
           P I  + LT++ Y +
Sbjct: 417 PTIERATLTRDFYLF 431


>gi|15431330 caspase 1 isoform gamma precursor [Homo sapiens]
          Length = 311

 Score = 80.1 bits (196), Expect = 2e-15
 Identities = 69/223 (30%), Positives = 96/223 (43%), Gaps = 28/223 (12%)

Query: 46  LCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIV-ELMRDVS 104
           L +II N+ F     +  R+G +VD   +    +NL Y V  K +LT  ++  EL     
Sbjct: 71  LALIICNEEFDS---IPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAH 127

Query: 105 KEDHSKRSSFVCVLLSHG-EEGIIFGTNGP-----VDLKKITNFFRGDRCRSLTGKPKLF 158
           + +H    S   V +SHG  EGI    +       + L  I N      C SL  KPK+ 
Sbjct: 128 RPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVI 187

Query: 159 IIQACRGTEL-------------DCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYS 205
           IIQACRG                +  + T    +DD A  K  +E DF+   S+ P   S
Sbjct: 188 IIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDD-AIKKAHIEKDFIAFCSSTPDNVS 246

Query: 206 WRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFE 248
           WR+   GS FI  L   +++YA   +   I     RKV   FE
Sbjct: 247 WRHPTMGSVFIGRLIEHMQEYACSCDVEEIF----RKVRFSFE 285


>gi|15431328 caspase 1 isoform alpha precursor [Homo sapiens]
          Length = 404

 Score = 80.1 bits (196), Expect = 2e-15
 Identities = 69/223 (30%), Positives = 96/223 (43%), Gaps = 28/223 (12%)

Query: 46  LCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIV-ELMRDVS 104
           L +II N+ F     +  R+G +VD   +    +NL Y V  K +LT  ++  EL     
Sbjct: 164 LALIICNEEFDS---IPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAH 220

Query: 105 KEDHSKRSSFVCVLLSHG-EEGIIFGTNGP-----VDLKKITNFFRGDRCRSLTGKPKLF 158
           + +H    S   V +SHG  EGI    +       + L  I N      C SL  KPK+ 
Sbjct: 221 RPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVI 280

Query: 159 IIQACRGTEL-------------DCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYS 205
           IIQACRG                +  + T    +DD A  K  +E DF+   S+ P   S
Sbjct: 281 IIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDD-AIKKAHIEKDFIAFCSSTPDNVS 339

Query: 206 WRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFE 248
           WR+   GS FI  L   +++YA   +   I     RKV   FE
Sbjct: 340 WRHPTMGSVFIGRLIEHMQEYACSCDVEEIF----RKVRFSFE 378


>gi|4502573 caspase 1 isoform beta precursor [Homo sapiens]
          Length = 383

 Score = 80.1 bits (196), Expect = 2e-15
 Identities = 69/223 (30%), Positives = 96/223 (43%), Gaps = 28/223 (12%)

Query: 46  LCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIV-ELMRDVS 104
           L +II N+ F     +  R+G +VD   +    +NL Y V  K +LT  ++  EL     
Sbjct: 143 LALIICNEEFDS---IPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAH 199

Query: 105 KEDHSKRSSFVCVLLSHG-EEGIIFGTNGP-----VDLKKITNFFRGDRCRSLTGKPKLF 158
           + +H    S   V +SHG  EGI    +       + L  I N      C SL  KPK+ 
Sbjct: 200 RPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVI 259

Query: 159 IIQACRGTEL-------------DCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYS 205
           IIQACRG                +  + T    +DD A  K  +E DF+   S+ P   S
Sbjct: 260 IIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDD-AIKKAHIEKDFIAFCSSTPDNVS 318

Query: 206 WRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFE 248
           WR+   GS FI  L   +++YA   +   I     RKV   FE
Sbjct: 319 WRHPTMGSVFIGRLIEHMQEYACSCDVEEIF----RKVRFSFE 357


>gi|209870075 caspase 5 isoform d [Homo sapiens]
          Length = 216

 Score = 73.9 bits (180), Expect = 1e-13
 Identities = 65/227 (28%), Positives = 98/227 (43%), Gaps = 38/227 (16%)

Query: 74  LRETFRNLKYEVRNKNDLTREEIVELMRD-VSKEDHSKRSSFVCVLLSHGEEGIIFGTNG 132
           ++   + L Y V ++ +LT  ++  ++R   ++ +H    S   VL+SHG   I+ G  G
Sbjct: 1   MKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHG---ILEGICG 57

Query: 133 PVDLKK---------ITNFFRGDRCRSLTGKPKLFIIQACRGTELD-------------C 170
               KK         I   F    C SL  KPK+ I+QACRG +                
Sbjct: 58  TAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALI 117

Query: 171 GIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKL 230
             ++   ++ D  C KI  E DF+   S+ P   SWR+   GS FI  L    ++Y+   
Sbjct: 118 SSQSSENLEADSVC-KIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCC 176

Query: 231 EFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIV-SMLTKELYFY 276
             M I     RKV   FE         AK Q+P I  + LT++ Y +
Sbjct: 177 HLMEIF----RKVQKSFE------VPQAKAQMPTIERATLTRDFYLF 213


>gi|187608577 CASP8 and FADD-like apoptosis regulator isoform 1
           [Homo sapiens]
          Length = 480

 Score = 65.9 bits (159), Expect = 4e-11
 Identities = 63/224 (28%), Positives = 98/224 (43%), Gaps = 33/224 (14%)

Query: 19  KIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETF 78
           K I  SE+       +  YKM    +G+C+II+              G + +   LR+TF
Sbjct: 226 KSIQESEAFLPQSIPEERYKMKSKPLGICLIIDC------------IGNETEL--LRDTF 271

Query: 79  RNLKYEVRNKNDLTREEIVELMRDVS-KEDHSKRSSFVCVLLSHGEEGIIFG---TNGPV 134
            +L YEV+    L+   I +++   +   +H    SFVCVL+S G    ++G   T+  +
Sbjct: 272 TSLGYEVQKFLHLSMHGISQILGQFACMPEHRDYDSFVCVLVSRGGSQSVYGVDQTHSGL 331

Query: 135 DLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDMACHK-------- 186
            L  I   F GD C  L GKPK+F IQ    +E    +E  S ++ D    K        
Sbjct: 332 PLHHIRRMFMGDSCPYLAGKPKMFFIQNYVVSEGQ--LEDSSLLEVDGPAMKNVEFKAQK 389

Query: 187 -----IPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQ 225
                +  EADF ++  TA      ++    S ++Q L   L+Q
Sbjct: 390 RGLCTVHREADFFWSLCTADMSLLEQSHSSPSLYLQCLSQKLRQ 433


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.134    0.399 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,963,069
Number of Sequences: 37866
Number of extensions: 421832
Number of successful extensions: 1006
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 37
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 894
Number of HSP's gapped (non-prelim): 44
length of query: 277
length of database: 18,247,518
effective HSP length: 101
effective length of query: 176
effective length of database: 14,423,052
effective search space: 2538457152
effective search space used: 2538457152
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 61 (28.1 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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