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Search of human proteins with 14790115
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|14790115 caspase 3 preproprotein [Homo sapiens]
(277 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|14790115 caspase 3 preproprotein [Homo sapiens] 568 e-162
gi|14790119 caspase 3 preproprotein [Homo sapiens] 568 e-162
gi|15718698 caspase 7 isoform delta [Homo sapiens] 282 3e-76
gi|15718700 caspase 7 isoform alpha [Homo sapiens] 282 3e-76
gi|4502581 caspase 7 isoform alpha precursor [Homo sapiens] 282 3e-76
gi|14916483 caspase 6 isoform alpha preproprotein [Homo sapiens] 204 9e-53
gi|14916485 caspase 6 isoform beta [Homo sapiens] 162 2e-40
gi|122056476 caspase 8 isoform G precursor [Homo sapiens] 159 3e-39
gi|122056474 caspase 8 isoform C precursor [Homo sapiens] 159 3e-39
gi|15718708 caspase 8 isoform C precursor [Homo sapiens] 159 3e-39
gi|15718706 caspase 8 isoform B precursor [Homo sapiens] 159 3e-39
gi|15718704 caspase 8 isoform A precursor [Homo sapiens] 159 3e-39
gi|14790124 caspase 9 isoform alpha preproprotein [Homo sapiens] 155 4e-38
gi|47078272 caspase 10 isoform d preproprotein [Homo sapiens] 130 2e-30
gi|47078267 caspase 10 isoform a preproprotein [Homo sapiens] 130 2e-30
gi|39995059 caspase 2 isoform 1 preproprotein [Homo sapiens] 124 1e-28
gi|47078269 caspase 10 isoform b preproprotein [Homo sapiens] 121 6e-28
gi|6912286 caspase 14 precursor [Homo sapiens] 102 4e-22
gi|15718702 caspase 7 isoform beta [Homo sapiens] 92 6e-19
gi|15451910 caspase 4 isoform gamma precursor [Homo sapiens] 89 5e-18
gi|4502577 caspase 4 isoform alpha precursor [Homo sapiens] 89 5e-18
gi|209870079 caspase 5 isoform f precursor [Homo sapiens] 83 3e-16
gi|209870073 caspase 5 isoform c [Homo sapiens] 83 3e-16
gi|209870071 caspase 5 isoform b precursor [Homo sapiens] 83 3e-16
gi|209870069 caspase 5 isoform a precursor [Homo sapiens] 83 3e-16
gi|15431330 caspase 1 isoform gamma precursor [Homo sapiens] 80 2e-15
gi|15431328 caspase 1 isoform alpha precursor [Homo sapiens] 80 2e-15
gi|4502573 caspase 1 isoform beta precursor [Homo sapiens] 80 2e-15
gi|209870075 caspase 5 isoform d [Homo sapiens] 74 1e-13
gi|187608577 CASP8 and FADD-like apoptosis regulator isoform 1 [... 66 4e-11
>gi|14790115 caspase 3 preproprotein [Homo sapiens]
Length = 277
Score = 568 bits (1463), Expect = e-162
Identities = 277/277 (100%), Positives = 277/277 (100%)
Query: 1 MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTG 60
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTG
Sbjct: 1 MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTG 60
Query: 61 MTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLS 120
MTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLS
Sbjct: 61 MTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLS 120
Query: 121 HGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDD 180
HGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDD
Sbjct: 121 HGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDD 180
Query: 181 DMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVN 240
DMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVN
Sbjct: 181 DMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVN 240
Query: 241 RKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH 277
RKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
Sbjct: 241 RKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH 277
>gi|14790119 caspase 3 preproprotein [Homo sapiens]
Length = 277
Score = 568 bits (1463), Expect = e-162
Identities = 277/277 (100%), Positives = 277/277 (100%)
Query: 1 MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTG 60
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTG
Sbjct: 1 MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTG 60
Query: 61 MTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLS 120
MTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLS
Sbjct: 61 MTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLS 120
Query: 121 HGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDD 180
HGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDD
Sbjct: 121 HGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDD 180
Query: 181 DMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVN 240
DMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVN
Sbjct: 181 DMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVN 240
Query: 241 RKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH 277
RKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
Sbjct: 241 RKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH 277
>gi|15718698 caspase 7 isoform delta [Homo sapiens]
Length = 336
Score = 282 bits (721), Expect = 3e-76
Identities = 138/242 (57%), Positives = 178/242 (73%), Gaps = 3/242 (1%)
Query: 37 YKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEI 96
Y M++ ++G CIIINNKNF K TGM R+GTD DA L + FR+L ++V ND + ++
Sbjct: 93 YNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKM 152
Query: 97 VELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPK 156
+L++ S+EDH+ + F C+LLSHGEE +I+G +G +K +T FRGDRC++L KPK
Sbjct: 153 QDLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPK 212
Query: 157 LFIIQACRGTELDCGIETDSGVDDDMAC---HKIPVEADFLYAYSTAPGYYSWRNSKDGS 213
LF IQACRGTELD GI+ DSG +D +KIPVEADFL+AYST PGYYSWR+ GS
Sbjct: 213 LFFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGS 272
Query: 214 WFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKEL 273
WF+Q+LC++L+++ LE M ILTRVN +VA FES S D FH KKQIPC+VSMLTKEL
Sbjct: 273 WFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKEL 332
Query: 274 YF 275
YF
Sbjct: 333 YF 334
>gi|15718700 caspase 7 isoform alpha [Homo sapiens]
Length = 303
Score = 282 bits (721), Expect = 3e-76
Identities = 138/242 (57%), Positives = 178/242 (73%), Gaps = 3/242 (1%)
Query: 37 YKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEI 96
Y M++ ++G CIIINNKNF K TGM R+GTD DA L + FR+L ++V ND + ++
Sbjct: 60 YNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKM 119
Query: 97 VELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPK 156
+L++ S+EDH+ + F C+LLSHGEE +I+G +G +K +T FRGDRC++L KPK
Sbjct: 120 QDLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPK 179
Query: 157 LFIIQACRGTELDCGIETDSGVDDDMAC---HKIPVEADFLYAYSTAPGYYSWRNSKDGS 213
LF IQACRGTELD GI+ DSG +D +KIPVEADFL+AYST PGYYSWR+ GS
Sbjct: 180 LFFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGS 239
Query: 214 WFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKEL 273
WF+Q+LC++L+++ LE M ILTRVN +VA FES S D FH KKQIPC+VSMLTKEL
Sbjct: 240 WFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKEL 299
Query: 274 YF 275
YF
Sbjct: 300 YF 301
>gi|4502581 caspase 7 isoform alpha precursor [Homo sapiens]
Length = 303
Score = 282 bits (721), Expect = 3e-76
Identities = 138/242 (57%), Positives = 178/242 (73%), Gaps = 3/242 (1%)
Query: 37 YKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEI 96
Y M++ ++G CIIINNKNF K TGM R+GTD DA L + FR+L ++V ND + ++
Sbjct: 60 YNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKM 119
Query: 97 VELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPK 156
+L++ S+EDH+ + F C+LLSHGEE +I+G +G +K +T FRGDRC++L KPK
Sbjct: 120 QDLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPK 179
Query: 157 LFIIQACRGTELDCGIETDSGVDDDMAC---HKIPVEADFLYAYSTAPGYYSWRNSKDGS 213
LF IQACRGTELD GI+ DSG +D +KIPVEADFL+AYST PGYYSWR+ GS
Sbjct: 180 LFFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGS 239
Query: 214 WFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKEL 273
WF+Q+LC++L+++ LE M ILTRVN +VA FES S D FH KKQIPC+VSMLTKEL
Sbjct: 240 WFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKEL 299
Query: 274 YF 275
YF
Sbjct: 300 YF 301
>gi|14916483 caspase 6 isoform alpha preproprotein [Homo sapiens]
Length = 293
Score = 204 bits (518), Expect = 9e-53
Identities = 105/253 (41%), Positives = 147/253 (58%), Gaps = 13/253 (5%)
Query: 37 YKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEI 96
YKMD+ G+ +I N++ F + R GT D NL F +L +EV+ NDL EE+
Sbjct: 37 YKMDHRRRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEEL 96
Query: 97 VELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPK 156
+ + +VS H+ FVCV LSHGE I+ + ++++ +T F+GD+C SL GKPK
Sbjct: 97 LLKIHEVSTVSHADADCFVCVFLSHGEGNHIYAYDAKIEIQTLTGLFKGDKCHSLVGKPK 156
Query: 157 LFIIQACRGTELDCGI-------------ETDSGVDDDMACHKIPVEADFLYAYSTAPGY 203
+FIIQACRG + D + +T+ D + + +P ADFL YS A GY
Sbjct: 157 IFIIQACRGNQHDVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMCYSVAEGY 216
Query: 204 YSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIP 263
YS R + +GSW+IQ LC ML +Y LEF +LT VNRKV+ F D + KKQ+P
Sbjct: 217 YSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQVP 276
Query: 264 CIVSMLTKELYFY 276
C SMLTK+L+F+
Sbjct: 277 CFASMLTKKLHFF 289
>gi|14916485 caspase 6 isoform beta [Homo sapiens]
Length = 204
Score = 162 bits (411), Expect = 2e-40
Identities = 83/187 (44%), Positives = 110/187 (58%), Gaps = 13/187 (6%)
Query: 103 VSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQA 162
VS H+ FVCV LSHGE I+ + ++++ +T F+GD+C SL GKPK+FIIQA
Sbjct: 14 VSTVSHADADCFVCVFLSHGEGNHIYAYDAKIEIQTLTGLFKGDKCHSLVGKPKIFIIQA 73
Query: 163 CRGTELDCGIETDSGVD-------------DDMACHKIPVEADFLYAYSTAPGYYSWRNS 209
CRG + D + VD D + + +P ADFL YS A GYYS R +
Sbjct: 74 CRGNQHDVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMCYSVAEGYYSHRET 133
Query: 210 KDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSML 269
+GSW+IQ LC ML +Y LEF +LT VNRKV+ F D + KKQ+PC SML
Sbjct: 134 VNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQVPCFASML 193
Query: 270 TKELYFY 276
TK+L+F+
Sbjct: 194 TKKLHFF 200
>gi|122056476 caspase 8 isoform G precursor [Homo sapiens]
Length = 538
Score = 159 bits (401), Expect = 3e-39
Identities = 99/262 (37%), Positives = 148/262 (56%), Gaps = 24/262 (9%)
Query: 32 SLDNSYKMDYPEMGLCIIINNKNFHKST-------GMTSRSGTDVDAANLRETFRNLKYE 84
+LD Y+M G C+IINN NF K+ + R+GT +DA L TF L +E
Sbjct: 280 TLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE 339
Query: 85 VRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNG-PVDLKKITNFF 143
++ +D T E+I E+++ DHS F+C +LSHG++GII+GT+G + ++T+ F
Sbjct: 340 IKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQF 399
Query: 144 RGDRCRSLTGKPKLFIIQACRGTELDCGI--ETDSG----VDDDMACHK---IPVEADFL 194
G +C SL GKPK+F IQAC+G GI ETDS ++ D++ + IP EADFL
Sbjct: 400 TGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFL 459
Query: 195 YAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADK-LEFMHILTRVNRKVATEFESFSFD 253
+T S+RN +G+W+IQSLC L++ + + + ILT VN +V+ + D
Sbjct: 460 LGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNK------D 513
Query: 254 ATFHAKKQIPCIVSMLTKELYF 275
+ KQ+P L K+L F
Sbjct: 514 DKKNMGKQMPQPTFTLRKKLVF 535
>gi|122056474 caspase 8 isoform C precursor [Homo sapiens]
Length = 464
Score = 159 bits (401), Expect = 3e-39
Identities = 99/262 (37%), Positives = 148/262 (56%), Gaps = 24/262 (9%)
Query: 32 SLDNSYKMDYPEMGLCIIINNKNFHKST-------GMTSRSGTDVDAANLRETFRNLKYE 84
+LD Y+M G C+IINN NF K+ + R+GT +DA L TF L +E
Sbjct: 206 TLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE 265
Query: 85 VRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNG-PVDLKKITNFF 143
++ +D T E+I E+++ DHS F+C +LSHG++GII+GT+G + ++T+ F
Sbjct: 266 IKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQF 325
Query: 144 RGDRCRSLTGKPKLFIIQACRGTELDCGI--ETDSG----VDDDMACHK---IPVEADFL 194
G +C SL GKPK+F IQAC+G GI ETDS ++ D++ + IP EADFL
Sbjct: 326 TGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFL 385
Query: 195 YAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADK-LEFMHILTRVNRKVATEFESFSFD 253
+T S+RN +G+W+IQSLC L++ + + + ILT VN +V+ + D
Sbjct: 386 LGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNK------D 439
Query: 254 ATFHAKKQIPCIVSMLTKELYF 275
+ KQ+P L K+L F
Sbjct: 440 DKKNMGKQMPQPTFTLRKKLVF 461
>gi|15718708 caspase 8 isoform C precursor [Homo sapiens]
Length = 464
Score = 159 bits (401), Expect = 3e-39
Identities = 99/262 (37%), Positives = 148/262 (56%), Gaps = 24/262 (9%)
Query: 32 SLDNSYKMDYPEMGLCIIINNKNFHKST-------GMTSRSGTDVDAANLRETFRNLKYE 84
+LD Y+M G C+IINN NF K+ + R+GT +DA L TF L +E
Sbjct: 206 TLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE 265
Query: 85 VRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNG-PVDLKKITNFF 143
++ +D T E+I E+++ DHS F+C +LSHG++GII+GT+G + ++T+ F
Sbjct: 266 IKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQF 325
Query: 144 RGDRCRSLTGKPKLFIIQACRGTELDCGI--ETDSG----VDDDMACHK---IPVEADFL 194
G +C SL GKPK+F IQAC+G GI ETDS ++ D++ + IP EADFL
Sbjct: 326 TGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFL 385
Query: 195 YAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADK-LEFMHILTRVNRKVATEFESFSFD 253
+T S+RN +G+W+IQSLC L++ + + + ILT VN +V+ + D
Sbjct: 386 LGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNK------D 439
Query: 254 ATFHAKKQIPCIVSMLTKELYF 275
+ KQ+P L K+L F
Sbjct: 440 DKKNMGKQMPQPTFTLRKKLVF 461
>gi|15718706 caspase 8 isoform B precursor [Homo sapiens]
Length = 479
Score = 159 bits (401), Expect = 3e-39
Identities = 99/262 (37%), Positives = 148/262 (56%), Gaps = 24/262 (9%)
Query: 32 SLDNSYKMDYPEMGLCIIINNKNFHKST-------GMTSRSGTDVDAANLRETFRNLKYE 84
+LD Y+M G C+IINN NF K+ + R+GT +DA L TF L +E
Sbjct: 221 TLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE 280
Query: 85 VRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNG-PVDLKKITNFF 143
++ +D T E+I E+++ DHS F+C +LSHG++GII+GT+G + ++T+ F
Sbjct: 281 IKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQF 340
Query: 144 RGDRCRSLTGKPKLFIIQACRGTELDCGI--ETDSG----VDDDMACHK---IPVEADFL 194
G +C SL GKPK+F IQAC+G GI ETDS ++ D++ + IP EADFL
Sbjct: 341 TGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFL 400
Query: 195 YAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADK-LEFMHILTRVNRKVATEFESFSFD 253
+T S+RN +G+W+IQSLC L++ + + + ILT VN +V+ + D
Sbjct: 401 LGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNK------D 454
Query: 254 ATFHAKKQIPCIVSMLTKELYF 275
+ KQ+P L K+L F
Sbjct: 455 DKKNMGKQMPQPTFTLRKKLVF 476
>gi|15718704 caspase 8 isoform A precursor [Homo sapiens]
Length = 496
Score = 159 bits (401), Expect = 3e-39
Identities = 99/262 (37%), Positives = 148/262 (56%), Gaps = 24/262 (9%)
Query: 32 SLDNSYKMDYPEMGLCIIINNKNFHKST-------GMTSRSGTDVDAANLRETFRNLKYE 84
+LD Y+M G C+IINN NF K+ + R+GT +DA L TF L +E
Sbjct: 238 TLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE 297
Query: 85 VRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNG-PVDLKKITNFF 143
++ +D T E+I E+++ DHS F+C +LSHG++GII+GT+G + ++T+ F
Sbjct: 298 IKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQF 357
Query: 144 RGDRCRSLTGKPKLFIIQACRGTELDCGI--ETDSG----VDDDMACHK---IPVEADFL 194
G +C SL GKPK+F IQAC+G GI ETDS ++ D++ + IP EADFL
Sbjct: 358 TGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFL 417
Query: 195 YAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADK-LEFMHILTRVNRKVATEFESFSFD 253
+T S+RN +G+W+IQSLC L++ + + + ILT VN +V+ + D
Sbjct: 418 LGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNK------D 471
Query: 254 ATFHAKKQIPCIVSMLTKELYF 275
+ KQ+P L K+L F
Sbjct: 472 DKKNMGKQMPQPTFTLRKKLVF 493
>gi|14790124 caspase 9 isoform alpha preproprotein [Homo sapiens]
Length = 416
Score = 155 bits (392), Expect = 4e-38
Identities = 91/274 (33%), Positives = 142/274 (51%), Gaps = 42/274 (15%)
Query: 34 DNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTR 93
D +Y + G C+IINN NF + +G+ +R+G+++D LR F +L + V K DLT
Sbjct: 150 DLAYILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTA 209
Query: 94 EEIVELMRDVSKEDHSKRSSFVCVLLSHGEE-------GIIFGTNG-PVDLKKITNFFRG 145
+++V + +++++DH V V+LSHG + G ++GT+G PV ++KI N F G
Sbjct: 210 KKMVLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNG 269
Query: 146 DRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDM----------------------- 182
C SL GKPKLF IQAC G + D G E S +D
Sbjct: 270 TSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQL 329
Query: 183 -ACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNR 241
A +P +D +YST PG+ SWR+ K GSW++++L + +Q+A + +L RV
Sbjct: 330 DAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVAN 389
Query: 242 KVATEFESFSFDATFHAKKQIPCIVSMLTKELYF 275
V+ + KQ+P + L K+L+F
Sbjct: 390 AVSVK----------GIYKQMPGCFNFLRKKLFF 413
>gi|47078272 caspase 10 isoform d preproprotein [Homo sapiens]
Length = 522
Score = 130 bits (326), Expect = 2e-30
Identities = 84/247 (34%), Positives = 132/247 (53%), Gaps = 17/247 (6%)
Query: 37 YKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEI 96
Y+M+ GLC+I+NN +F T + R GT DA L F+ L + V N++T+ E+
Sbjct: 276 YRMNRNHRGLCVIVNNHSF---TSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEM 332
Query: 97 -VELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGP-VDLKKITNFFRGDRCRSLTGK 154
+ L + H+ FV +L+HG G ++ ++ + +++I + F +C L K
Sbjct: 333 EMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDEALIPIREIMSHFTALQCPRLAEK 392
Query: 155 PKLFIIQACRGTELDCGIETDS-GVDDDMAC----HKIPVEADFLYAYSTAPGYYSWRNS 209
PKLF IQAC+G E+ + ++ ++ + A IP EADFL +T PGY S+R+
Sbjct: 393 PKLFFIQACQGEEIQPSVSIEADALNPEQAPTSLQDSIPAEADFLLGLATVPGYVSFRHV 452
Query: 210 KDGSWFIQSLCAMLKQYADKLE-FMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSM 268
++GSW+IQSLC LK+ + E + ILT VN V+ + KKQ+P
Sbjct: 453 EEGSWYIQSLCNHLKKLVPRHEDILSILTAVNDDVSRRVDKQG------TKKQMPQPAFT 506
Query: 269 LTKELYF 275
L K+L F
Sbjct: 507 LRKKLVF 513
>gi|47078267 caspase 10 isoform a preproprotein [Homo sapiens]
Length = 479
Score = 130 bits (326), Expect = 2e-30
Identities = 84/247 (34%), Positives = 132/247 (53%), Gaps = 17/247 (6%)
Query: 37 YKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEI 96
Y+M+ GLC+I+NN +F T + R GT DA L F+ L + V N++T+ E+
Sbjct: 233 YRMNRNHRGLCVIVNNHSF---TSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEM 289
Query: 97 -VELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGP-VDLKKITNFFRGDRCRSLTGK 154
+ L + H+ FV +L+HG G ++ ++ + +++I + F +C L K
Sbjct: 290 EMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDEALIPIREIMSHFTALQCPRLAEK 349
Query: 155 PKLFIIQACRGTELDCGIETDS-GVDDDMAC----HKIPVEADFLYAYSTAPGYYSWRNS 209
PKLF IQAC+G E+ + ++ ++ + A IP EADFL +T PGY S+R+
Sbjct: 350 PKLFFIQACQGEEIQPSVSIEADALNPEQAPTSLQDSIPAEADFLLGLATVPGYVSFRHV 409
Query: 210 KDGSWFIQSLCAMLKQYADKLE-FMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSM 268
++GSW+IQSLC LK+ + E + ILT VN V+ + KKQ+P
Sbjct: 410 EEGSWYIQSLCNHLKKLVPRHEDILSILTAVNDDVSRRVDKQG------TKKQMPQPAFT 463
Query: 269 LTKELYF 275
L K+L F
Sbjct: 464 LRKKLVF 470
>gi|39995059 caspase 2 isoform 1 preproprotein [Homo sapiens]
Length = 452
Score = 124 bits (310), Expect = 1e-28
Identities = 75/257 (29%), Positives = 130/257 (50%), Gaps = 17/257 (6%)
Query: 36 SYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREE 95
+Y++ GL ++++N +F + RSG DVD + L F+ L Y+V D T +E
Sbjct: 191 AYRLQSRPRGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQE 250
Query: 96 IVELMRDVSK-EDHSKRSSFVCVLLSHGEEGIIFGTNGPV-DLKKITNFFRGDRCRSLTG 153
+ E +++ ++ H S + LLSHG EG I+G +G + L+++ F C SL
Sbjct: 251 MQEKLQNFAQLPAHRVTDSCIVALLSHGVEGAIYGVDGKLLQLQEVFQLFDNANCPSLQN 310
Query: 154 KPKLFIIQACRGTELDCGIETDSGVD--------------DDMACHKIPVEADFLYAYST 199
KPK+F IQACRG E D G++ G + + + ++P +D + Y+
Sbjct: 311 KPKMFFIQACRGDETDRGVDQQDGKNHAGSPGCEESDAGKEKLPKMRLPTRSDMICGYAC 370
Query: 200 APGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAK 259
G + RN+K GSW+I++L + + A + +L +VN + + E ++ FH
Sbjct: 371 LKGTAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVNALI-KDREGYAPGTEFHRC 429
Query: 260 KQIPCIVSMLTKELYFY 276
K++ S L + LY +
Sbjct: 430 KEMSEYCSTLCRHLYLF 446
>gi|47078269 caspase 10 isoform b preproprotein [Homo sapiens]
Length = 521
Score = 121 bits (304), Expect = 6e-28
Identities = 74/227 (32%), Positives = 123/227 (54%), Gaps = 11/227 (4%)
Query: 37 YKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEI 96
Y+M+ GLC+I+NN +F T + R GT DA L F+ L + V N++T+ E+
Sbjct: 276 YRMNRNHRGLCVIVNNHSF---TSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEM 332
Query: 97 -VELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGP-VDLKKITNFFRGDRCRSLTGK 154
+ L + H+ FV +L+HG G ++ ++ + +++I + F +C L K
Sbjct: 333 EMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDEALIPIREIMSHFTALQCPRLAEK 392
Query: 155 PKLFIIQACRGTELDCGIETDS-GVDDDMAC----HKIPVEADFLYAYSTAPGYYSWRNS 209
PKLF IQAC+G E+ + ++ ++ + A IP EADFL +T PGY S+R+
Sbjct: 393 PKLFFIQACQGEEIQPSVSIEADALNPEQAPTSLQDSIPAEADFLLGLATVPGYVSFRHV 452
Query: 210 KDGSWFIQSLCAMLKQYADK-LEFMHILTRVNRKVATEFESFSFDAT 255
++GSW+IQSLC LK+ + L+F+ + + T + + AT
Sbjct: 453 EEGSWYIQSLCNHLKKLVPRMLKFLEKTMEIRGRKRTVWGAKQISAT 499
>gi|6912286 caspase 14 precursor [Homo sapiens]
Length = 242
Score = 102 bits (254), Expect = 4e-22
Identities = 74/220 (33%), Positives = 108/220 (49%), Gaps = 15/220 (6%)
Query: 63 SRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVC---VLL 119
+R G++ D L FR L++E K D T E+ E + + S+ C VL+
Sbjct: 28 AREGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQQAIDSREDPVSCAFVVLM 87
Query: 120 SHGEEGIIFGTNGP-VDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGV 178
+HG EG + G +G V L+ + C++L KPK++IIQACRG + D G ET G
Sbjct: 88 AHGREGFLKGEDGEMVKLENLFEALNNKNCQALRAKPKVYIIQACRGEQRDPG-ETVGGD 146
Query: 179 DDDMAC----HKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMH 234
+ M IP D L+ YST GY ++R+ + GS FIQ+L + + K +
Sbjct: 147 EIVMVIKDSPQTIPTYTDALHVYSTVEGYIAYRHDQKGSCFIQTLVDVFTK--RKGHILE 204
Query: 235 ILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELY 274
+LT V R++A A+K P I S L K LY
Sbjct: 205 LLTEVTRRMA----EAELVQEGKARKTNPEIQSTLRKRLY 240
>gi|15718702 caspase 7 isoform beta [Homo sapiens]
Length = 253
Score = 91.7 bits (226), Expect = 6e-19
Identities = 43/90 (47%), Positives = 63/90 (70%)
Query: 37 YKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEI 96
Y M++ ++G CIIINNKNF K TGM R+GTD DA L + FR+L ++V ND + ++
Sbjct: 60 YNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKM 119
Query: 97 VELMRDVSKEDHSKRSSFVCVLLSHGEEGI 126
+L++ S+EDH+ + F C+LLSHGEE +
Sbjct: 120 QDLLKKASEEDHTNAACFACILLSHGEENM 149
>gi|15451910 caspase 4 isoform gamma precursor [Homo sapiens]
Length = 321
Score = 88.6 bits (218), Expect = 5e-18
Identities = 81/253 (32%), Positives = 111/253 (43%), Gaps = 39/253 (15%)
Query: 46 LCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRD-VS 104
L +II N F + R+G D D ++E L Y V + +LT ++ +R +
Sbjct: 81 LALIICNTEFDH---LPPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFAT 137
Query: 105 KEDHSKRSSFVCVLLSHGEEGIIFGTNGPV-DLKK--------ITNFFRGDRCRSLTGKP 155
+ +H S VL+SHG I+ G G V D KK I F C SL KP
Sbjct: 138 RPEHKSSDSTFLVLMSHG---ILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKP 194
Query: 156 KLFIIQACRGTE------------LDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGY 203
K+ I+QACRG L+ S ++ A +K VE DF+ S+ P
Sbjct: 195 KVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHN 254
Query: 204 YSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIP 263
SWR+S GS FI L ++Y+ + L V RKV FE T AK Q+P
Sbjct: 255 VSWRDSTMGSIFITQLITCFQKYS----WCCHLEEVFRKVQQSFE------TPRAKAQMP 304
Query: 264 CIVSMLTKELYFY 276
I L+ YFY
Sbjct: 305 TI-ERLSMTRYFY 316
>gi|4502577 caspase 4 isoform alpha precursor [Homo sapiens]
Length = 377
Score = 88.6 bits (218), Expect = 5e-18
Identities = 81/253 (32%), Positives = 111/253 (43%), Gaps = 39/253 (15%)
Query: 46 LCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRD-VS 104
L +II N F + R+G D D ++E L Y V + +LT ++ +R +
Sbjct: 137 LALIICNTEFDH---LPPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFAT 193
Query: 105 KEDHSKRSSFVCVLLSHGEEGIIFGTNGPV-DLKK--------ITNFFRGDRCRSLTGKP 155
+ +H S VL+SHG I+ G G V D KK I F C SL KP
Sbjct: 194 RPEHKSSDSTFLVLMSHG---ILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKP 250
Query: 156 KLFIIQACRGTE------------LDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGY 203
K+ I+QACRG L+ S ++ A +K VE DF+ S+ P
Sbjct: 251 KVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHN 310
Query: 204 YSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIP 263
SWR+S GS FI L ++Y+ + L V RKV FE T AK Q+P
Sbjct: 311 VSWRDSTMGSIFITQLITCFQKYS----WCCHLEEVFRKVQQSFE------TPRAKAQMP 360
Query: 264 CIVSMLTKELYFY 276
I L+ YFY
Sbjct: 361 TI-ERLSMTRYFY 372
>gi|209870079 caspase 5 isoform f precursor [Homo sapiens]
Length = 447
Score = 82.8 bits (203), Expect = 3e-16
Identities = 73/255 (28%), Positives = 110/255 (43%), Gaps = 41/255 (16%)
Query: 46 LCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRD-VS 104
L +II N F + +R+G D ++ + L Y V ++ +LT ++ ++R +
Sbjct: 207 LALIICNTKFDH---LPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAA 263
Query: 105 KEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKK---------ITNFFRGDRCRSLTGKP 155
+ +H S VL+SHG I+ G G KK I F C SL KP
Sbjct: 264 RPEHKSSDSTFLVLMSHG---ILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKP 320
Query: 156 KLFIIQACRGTELD-------------CGIETDSGVDDDMACHKIPVEADFLYAYSTAPG 202
K+ I+QACRG + ++ ++ D C KI E DF+ S+ P
Sbjct: 321 KVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVC-KIHEEKDFIAFCSSTPH 379
Query: 203 YYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQI 262
SWR+ GS FI L ++Y+ M I RKV FE AK Q+
Sbjct: 380 NVSWRDRTRGSIFITELITCFQKYSCCCHLMEIF----RKVQKSFE------VPQAKAQM 429
Query: 263 PCIV-SMLTKELYFY 276
P I + LT++ Y +
Sbjct: 430 PTIERATLTRDFYLF 444
>gi|209870073 caspase 5 isoform c [Homo sapiens]
Length = 292
Score = 82.8 bits (203), Expect = 3e-16
Identities = 73/255 (28%), Positives = 110/255 (43%), Gaps = 41/255 (16%)
Query: 46 LCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRD-VS 104
L +II N F + +R+G D ++ + L Y V ++ +LT ++ ++R +
Sbjct: 52 LALIICNTKFDH---LPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAA 108
Query: 105 KEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKK---------ITNFFRGDRCRSLTGKP 155
+ +H S VL+SHG I+ G G KK I F C SL KP
Sbjct: 109 RPEHKSSDSTFLVLMSHG---ILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKP 165
Query: 156 KLFIIQACRGTELD-------------CGIETDSGVDDDMACHKIPVEADFLYAYSTAPG 202
K+ I+QACRG + ++ ++ D C KI E DF+ S+ P
Sbjct: 166 KVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVC-KIHEEKDFIAFCSSTPH 224
Query: 203 YYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQI 262
SWR+ GS FI L ++Y+ M I RKV FE AK Q+
Sbjct: 225 NVSWRDRTRGSIFITELITCFQKYSCCCHLMEIF----RKVQKSFE------VPQAKAQM 274
Query: 263 PCIV-SMLTKELYFY 276
P I + LT++ Y +
Sbjct: 275 PTIERATLTRDFYLF 289
>gi|209870071 caspase 5 isoform b precursor [Homo sapiens]
Length = 376
Score = 82.8 bits (203), Expect = 3e-16
Identities = 73/255 (28%), Positives = 110/255 (43%), Gaps = 41/255 (16%)
Query: 46 LCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRD-VS 104
L +II N F + +R+G D ++ + L Y V ++ +LT ++ ++R +
Sbjct: 136 LALIICNTKFDH---LPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAA 192
Query: 105 KEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKK---------ITNFFRGDRCRSLTGKP 155
+ +H S VL+SHG I+ G G KK I F C SL KP
Sbjct: 193 RPEHKSSDSTFLVLMSHG---ILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKP 249
Query: 156 KLFIIQACRGTELD-------------CGIETDSGVDDDMACHKIPVEADFLYAYSTAPG 202
K+ I+QACRG + ++ ++ D C KI E DF+ S+ P
Sbjct: 250 KVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVC-KIHEEKDFIAFCSSTPH 308
Query: 203 YYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQI 262
SWR+ GS FI L ++Y+ M I RKV FE AK Q+
Sbjct: 309 NVSWRDRTRGSIFITELITCFQKYSCCCHLMEIF----RKVQKSFE------VPQAKAQM 358
Query: 263 PCIV-SMLTKELYFY 276
P I + LT++ Y +
Sbjct: 359 PTIERATLTRDFYLF 373
>gi|209870069 caspase 5 isoform a precursor [Homo sapiens]
Length = 434
Score = 82.8 bits (203), Expect = 3e-16
Identities = 73/255 (28%), Positives = 110/255 (43%), Gaps = 41/255 (16%)
Query: 46 LCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRD-VS 104
L +II N F + +R+G D ++ + L Y V ++ +LT ++ ++R +
Sbjct: 194 LALIICNTKFDH---LPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAA 250
Query: 105 KEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKK---------ITNFFRGDRCRSLTGKP 155
+ +H S VL+SHG I+ G G KK I F C SL KP
Sbjct: 251 RPEHKSSDSTFLVLMSHG---ILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKP 307
Query: 156 KLFIIQACRGTELD-------------CGIETDSGVDDDMACHKIPVEADFLYAYSTAPG 202
K+ I+QACRG + ++ ++ D C KI E DF+ S+ P
Sbjct: 308 KVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVC-KIHEEKDFIAFCSSTPH 366
Query: 203 YYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQI 262
SWR+ GS FI L ++Y+ M I RKV FE AK Q+
Sbjct: 367 NVSWRDRTRGSIFITELITCFQKYSCCCHLMEIF----RKVQKSFE------VPQAKAQM 416
Query: 263 PCIV-SMLTKELYFY 276
P I + LT++ Y +
Sbjct: 417 PTIERATLTRDFYLF 431
>gi|15431330 caspase 1 isoform gamma precursor [Homo sapiens]
Length = 311
Score = 80.1 bits (196), Expect = 2e-15
Identities = 69/223 (30%), Positives = 96/223 (43%), Gaps = 28/223 (12%)
Query: 46 LCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIV-ELMRDVS 104
L +II N+ F + R+G +VD + +NL Y V K +LT ++ EL
Sbjct: 71 LALIICNEEFDS---IPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAH 127
Query: 105 KEDHSKRSSFVCVLLSHG-EEGIIFGTNGP-----VDLKKITNFFRGDRCRSLTGKPKLF 158
+ +H S V +SHG EGI + + L I N C SL KPK+
Sbjct: 128 RPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVI 187
Query: 159 IIQACRGTEL-------------DCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYS 205
IIQACRG + + T +DD A K +E DF+ S+ P S
Sbjct: 188 IIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDD-AIKKAHIEKDFIAFCSSTPDNVS 246
Query: 206 WRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFE 248
WR+ GS FI L +++YA + I RKV FE
Sbjct: 247 WRHPTMGSVFIGRLIEHMQEYACSCDVEEIF----RKVRFSFE 285
>gi|15431328 caspase 1 isoform alpha precursor [Homo sapiens]
Length = 404
Score = 80.1 bits (196), Expect = 2e-15
Identities = 69/223 (30%), Positives = 96/223 (43%), Gaps = 28/223 (12%)
Query: 46 LCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIV-ELMRDVS 104
L +II N+ F + R+G +VD + +NL Y V K +LT ++ EL
Sbjct: 164 LALIICNEEFDS---IPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAH 220
Query: 105 KEDHSKRSSFVCVLLSHG-EEGIIFGTNGP-----VDLKKITNFFRGDRCRSLTGKPKLF 158
+ +H S V +SHG EGI + + L I N C SL KPK+
Sbjct: 221 RPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVI 280
Query: 159 IIQACRGTEL-------------DCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYS 205
IIQACRG + + T +DD A K +E DF+ S+ P S
Sbjct: 281 IIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDD-AIKKAHIEKDFIAFCSSTPDNVS 339
Query: 206 WRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFE 248
WR+ GS FI L +++YA + I RKV FE
Sbjct: 340 WRHPTMGSVFIGRLIEHMQEYACSCDVEEIF----RKVRFSFE 378
>gi|4502573 caspase 1 isoform beta precursor [Homo sapiens]
Length = 383
Score = 80.1 bits (196), Expect = 2e-15
Identities = 69/223 (30%), Positives = 96/223 (43%), Gaps = 28/223 (12%)
Query: 46 LCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIV-ELMRDVS 104
L +II N+ F + R+G +VD + +NL Y V K +LT ++ EL
Sbjct: 143 LALIICNEEFDS---IPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAH 199
Query: 105 KEDHSKRSSFVCVLLSHG-EEGIIFGTNGP-----VDLKKITNFFRGDRCRSLTGKPKLF 158
+ +H S V +SHG EGI + + L I N C SL KPK+
Sbjct: 200 RPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVI 259
Query: 159 IIQACRGTEL-------------DCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYS 205
IIQACRG + + T +DD A K +E DF+ S+ P S
Sbjct: 260 IIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDD-AIKKAHIEKDFIAFCSSTPDNVS 318
Query: 206 WRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFE 248
WR+ GS FI L +++YA + I RKV FE
Sbjct: 319 WRHPTMGSVFIGRLIEHMQEYACSCDVEEIF----RKVRFSFE 357
>gi|209870075 caspase 5 isoform d [Homo sapiens]
Length = 216
Score = 73.9 bits (180), Expect = 1e-13
Identities = 65/227 (28%), Positives = 98/227 (43%), Gaps = 38/227 (16%)
Query: 74 LRETFRNLKYEVRNKNDLTREEIVELMRD-VSKEDHSKRSSFVCVLLSHGEEGIIFGTNG 132
++ + L Y V ++ +LT ++ ++R ++ +H S VL+SHG I+ G G
Sbjct: 1 MKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHG---ILEGICG 57
Query: 133 PVDLKK---------ITNFFRGDRCRSLTGKPKLFIIQACRGTELD-------------C 170
KK I F C SL KPK+ I+QACRG +
Sbjct: 58 TAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALI 117
Query: 171 GIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKL 230
++ ++ D C KI E DF+ S+ P SWR+ GS FI L ++Y+
Sbjct: 118 SSQSSENLEADSVC-KIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCC 176
Query: 231 EFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIV-SMLTKELYFY 276
M I RKV FE AK Q+P I + LT++ Y +
Sbjct: 177 HLMEIF----RKVQKSFE------VPQAKAQMPTIERATLTRDFYLF 213
>gi|187608577 CASP8 and FADD-like apoptosis regulator isoform 1
[Homo sapiens]
Length = 480
Score = 65.9 bits (159), Expect = 4e-11
Identities = 63/224 (28%), Positives = 98/224 (43%), Gaps = 33/224 (14%)
Query: 19 KIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETF 78
K I SE+ + YKM +G+C+II+ G + + LR+TF
Sbjct: 226 KSIQESEAFLPQSIPEERYKMKSKPLGICLIIDC------------IGNETEL--LRDTF 271
Query: 79 RNLKYEVRNKNDLTREEIVELMRDVS-KEDHSKRSSFVCVLLSHGEEGIIFG---TNGPV 134
+L YEV+ L+ I +++ + +H SFVCVL+S G ++G T+ +
Sbjct: 272 TSLGYEVQKFLHLSMHGISQILGQFACMPEHRDYDSFVCVLVSRGGSQSVYGVDQTHSGL 331
Query: 135 DLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDMACHK-------- 186
L I F GD C L GKPK+F IQ +E +E S ++ D K
Sbjct: 332 PLHHIRRMFMGDSCPYLAGKPKMFFIQNYVVSEGQ--LEDSSLLEVDGPAMKNVEFKAQK 389
Query: 187 -----IPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQ 225
+ EADF ++ TA ++ S ++Q L L+Q
Sbjct: 390 RGLCTVHREADFFWSLCTADMSLLEQSHSSPSLYLQCLSQKLRQ 433
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.399
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,963,069
Number of Sequences: 37866
Number of extensions: 421832
Number of successful extensions: 1006
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 37
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 894
Number of HSP's gapped (non-prelim): 44
length of query: 277
length of database: 18,247,518
effective HSP length: 101
effective length of query: 176
effective length of database: 14,423,052
effective search space: 2538457152
effective search space used: 2538457152
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.