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Search of human proteins with 146219841
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|146219841 PNMA-like 2 [Homo sapiens]
(635 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|146219841 PNMA-like 2 [Homo sapiens] 1253 0.0
gi|156766054 PNMA-like 1 isoform b [Homo sapiens] 117 4e-26
gi|39780597 PNMA-like 1 isoform a [Homo sapiens] 117 4e-26
gi|11464969 paraneoplastic antigen MA2 [Homo sapiens] 108 1e-23
gi|52486265 paraneoplastic antigen MA1 [Homo sapiens] 104 2e-22
gi|19923584 modulator of apoptosis 1 [Homo sapiens] 97 3e-20
gi|169216514 PREDICTED: similar to paraneoplastic antigen MA2 [H... 92 2e-18
gi|169216749 PREDICTED: similar to Putative paraneoplastic antig... 92 2e-18
gi|142976816 paraneoplastic cancer-testis-brain antigen [Homo sa... 91 3e-18
gi|156766066 paraneoplastic antigen like 5 [Homo sapiens] 89 2e-17
gi|156766064 paraneoplastic antigen like 5 [Homo sapiens] 89 2e-17
gi|24308384 paraneoplastic antigen like 5 [Homo sapiens] 89 2e-17
gi|239746972 PREDICTED: hypothetical protein XP_002343899 [Homo ... 87 5e-17
gi|239746970 PREDICTED: hypothetical protein XP_002343898 [Homo ... 87 5e-17
gi|239746974 PREDICTED: hypothetical protein XP_002343900 [Homo ... 87 6e-17
gi|187607308 paraneoplastic antigen like 6A [Homo sapiens] 87 6e-17
gi|169217313 PREDICTED: similar to paraneoplastic antigen MA1 [H... 81 3e-15
gi|169216507 PREDICTED: similar to hCG1645335 [Homo sapiens] 81 3e-15
gi|169216516 PREDICTED: similar to paraneoplastic antigen MA1 [H... 81 3e-15
gi|169216732 PREDICTED: similar to hCG1645335 [Homo sapiens] 81 3e-15
gi|239746976 PREDICTED: similar to paraneoplastic antigen MA1 [H... 81 3e-15
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e... 50 6e-06
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d... 50 6e-06
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ... 50 6e-06
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ... 50 6e-06
gi|21396500 HIRA interacting protein 3 [Homo sapiens] 49 1e-05
gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f... 47 4e-05
gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ... 47 4e-05
gi|239751791 PREDICTED: hypothetical protein [Homo sapiens] 47 7e-05
gi|239746282 PREDICTED: hypothetical protein XP_002343723 [Homo ... 47 7e-05
>gi|146219841 PNMA-like 2 [Homo sapiens]
Length = 635
Score = 1253 bits (3241), Expect = 0.0
Identities = 635/635 (100%), Positives = 635/635 (100%)
Query: 1 MAMSLLQDWCRSLDVDAHRALLVTGIPEGLEQADVEAVLQPTLLPLGTFRLRHMKALMNE 60
MAMSLLQDWCRSLDVDAHRALLVTGIPEGLEQADVEAVLQPTLLPLGTFRLRHMKALMNE
Sbjct: 1 MAMSLLQDWCRSLDVDAHRALLVTGIPEGLEQADVEAVLQPTLLPLGTFRLRHMKALMNE 60
Query: 61 KAQAALVEFVEDVNHAAIPREIPGKDGVWRVLWKDRAQDTRVLRQMRRLLLDDGPTQAAE 120
KAQAALVEFVEDVNHAAIPREIPGKDGVWRVLWKDRAQDTRVLRQMRRLLLDDGPTQAAE
Sbjct: 61 KAQAALVEFVEDVNHAAIPREIPGKDGVWRVLWKDRAQDTRVLRQMRRLLLDDGPTQAAE 120
Query: 121 AGTPGEAPTPPASETQAQDSGEVTGQAGSLLGAARNPRRGRRGRRNRTRRNRLTQKGKKR 180
AGTPGEAPTPPASETQAQDSGEVTGQAGSLLGAARNPRRGRRGRRNRTRRNRLTQKGKKR
Sbjct: 121 AGTPGEAPTPPASETQAQDSGEVTGQAGSLLGAARNPRRGRRGRRNRTRRNRLTQKGKKR 180
Query: 181 SRGGRPSAPARSEAEDSSDESLGIVIEEIDQGDLSGEEDQSALYATLQAAARELVRQWAP 240
SRGGRPSAPARSEAEDSSDESLGIVIEEIDQGDLSGEEDQSALYATLQAAARELVRQWAP
Sbjct: 181 SRGGRPSAPARSEAEDSSDESLGIVIEEIDQGDLSGEEDQSALYATLQAAARELVRQWAP 240
Query: 241 CNSEGEEDGPREFLALVTVTDKSKKEEAEKEPAGAESIRLNTKEDKNGVPDLVALLAVRD 300
CNSEGEEDGPREFLALVTVTDKSKKEEAEKEPAGAESIRLNTKEDKNGVPDLVALLAVRD
Sbjct: 241 CNSEGEEDGPREFLALVTVTDKSKKEEAEKEPAGAESIRLNTKEDKNGVPDLVALLAVRD 300
Query: 301 TPDEEPVDSDTSESDSQESGDQETEELDNPEFVAIVAYTDPSDPWAREEMLKIASVIESL 360
TPDEEPVDSDTSESDSQESGDQETEELDNPEFVAIVAYTDPSDPWAREEMLKIASVIESL
Sbjct: 301 TPDEEPVDSDTSESDSQESGDQETEELDNPEFVAIVAYTDPSDPWAREEMLKIASVIESL 360
Query: 361 GWSDEKDKRDPLRQVLSVMSKDTNGTRVKVEEAGREVDAVVLRKAGDDGDLRECISTLAQ 420
GWSDEKDKRDPLRQVLSVMSKDTNGTRVKVEEAGREVDAVVLRKAGDDGDLRECISTLAQ
Sbjct: 361 GWSDEKDKRDPLRQVLSVMSKDTNGTRVKVEEAGREVDAVVLRKAGDDGDLRECISTLAQ 420
Query: 421 PDLPPQAKKAGRGLFGGWSEHREDEGGLLELVALLAAQDMAEVMKEEKENAWEGGKYKYP 480
PDLPPQAKKAGRGLFGGWSEHREDEGGLLELVALLAAQDMAEVMKEEKENAWEGGKYKYP
Sbjct: 421 PDLPPQAKKAGRGLFGGWSEHREDEGGLLELVALLAAQDMAEVMKEEKENAWEGGKYKYP 480
Query: 481 KGKLGEVLALLAARENMGSNEGSEEASDEQSEEESEDTESEASEPEDRASRKPRAKRART 540
KGKLGEVLALLAARENMGSNEGSEEASDEQSEEESEDTESEASEPEDRASRKPRAKRART
Sbjct: 481 KGKLGEVLALLAARENMGSNEGSEEASDEQSEEESEDTESEASEPEDRASRKPRAKRART 540
Query: 541 APRGLTPAGAPPTASGARKTRAGGRGRGRGVTPEKKAGSRGSAQDDAAGSRKKKGSAGAG 600
APRGLTPAGAPPTASGARKTRAGGRGRGRGVTPEKKAGSRGSAQDDAAGSRKKKGSAGAG
Sbjct: 541 APRGLTPAGAPPTASGARKTRAGGRGRGRGVTPEKKAGSRGSAQDDAAGSRKKKGSAGAG 600
Query: 601 AHARAGEAKGQAPTGSKAARGKKARRGRRLPPKCR 635
AHARAGEAKGQAPTGSKAARGKKARRGRRLPPKCR
Sbjct: 601 AHARAGEAKGQAPTGSKAARGKKARRGRRLPPKCR 635
>gi|156766054 PNMA-like 1 isoform b [Homo sapiens]
Length = 378
Score = 117 bits (292), Expect = 4e-26
Identities = 65/153 (42%), Positives = 88/153 (57%), Gaps = 1/153 (0%)
Query: 1 MAMSLLQDWCRSLDVDAHRALLVTGIPEGLEQADVEAVLQPTLLPLGTFRLRHMKALMNE 60
MAM+LL+DWCR ++VD HR+LLVTGIPE QA++E L L PLG +R+ + + E
Sbjct: 5 MAMNLLEDWCRGMEVDIHRSLLVTGIPEDCGQAEIEETLNGVLSPLGPYRVLNKIFVREE 64
Query: 61 KAQAALVEFVEDVNHAAIPREIPGKDGVWRVLWKDRAQDTRVLRQMRRLLLDDGPTQAAE 120
+AAL+E E VN + IPRE PG+ GVWRV+ +D QD L+ + L +G T +
Sbjct: 65 NVKAALIEVGEGVNLSTIPREFPGRGGVWRVVCRDPTQDAEFLKNLNEFLDAEGRTW-ED 123
Query: 121 AGTPGEAPTPPASETQAQDSGEVTGQAGSLLGA 153
+ P S+ Q Q G LLGA
Sbjct: 124 VVRLLQLNHPTLSQNQHQPPENWAEALGVLLGA 156
>gi|39780597 PNMA-like 1 isoform a [Homo sapiens]
Length = 439
Score = 117 bits (292), Expect = 4e-26
Identities = 65/153 (42%), Positives = 88/153 (57%), Gaps = 1/153 (0%)
Query: 1 MAMSLLQDWCRSLDVDAHRALLVTGIPEGLEQADVEAVLQPTLLPLGTFRLRHMKALMNE 60
MAM+LL+DWCR ++VD HR+LLVTGIPE QA++E L L PLG +R+ + + E
Sbjct: 5 MAMNLLEDWCRGMEVDIHRSLLVTGIPEDCGQAEIEETLNGVLSPLGPYRVLNKIFVREE 64
Query: 61 KAQAALVEFVEDVNHAAIPREIPGKDGVWRVLWKDRAQDTRVLRQMRRLLLDDGPTQAAE 120
+AAL+E E VN + IPRE PG+ GVWRV+ +D QD L+ + L +G T +
Sbjct: 65 NVKAALIEVGEGVNLSTIPREFPGRGGVWRVVCRDPTQDAEFLKNLNEFLDAEGRTW-ED 123
Query: 121 AGTPGEAPTPPASETQAQDSGEVTGQAGSLLGA 153
+ P S+ Q Q G LLGA
Sbjct: 124 VVRLLQLNHPTLSQNQHQPPENWAEALGVLLGA 156
Score = 46.2 bits (108), Expect = 9e-05
Identities = 52/208 (25%), Positives = 78/208 (37%), Gaps = 32/208 (15%)
Query: 438 WSEHREDEGGLLELVALLAAQDMAEVMKEEKENAWEGGKYKYPKGKLGEVLALLAARENM 497
W+ + LV A+ + K++K + E +K PKG N
Sbjct: 218 WNATEDQHEPTKPLVRRAGAKSRSRRKKQKKNSRQEAVPWKKPKG----------INSNS 267
Query: 498 GSNEGSEEASDEQSEEESEDTESEAS---EPEDRASRKPRAKRARTAPRGLTPAGAPPTA 554
+N E D +S SE + E+ A +KP AK A PR PP
Sbjct: 268 TANLEDPEVGDAESMAISEPIKGSRKPCVNKEELALKKPMAKCAWKGPR------EPPQD 321
Query: 555 SGARKTRAGGRGR-----GRGVTPEKKAGSRGSAQDDAAGSRKKKGSAGAGAHARAGEAK 609
+ A GG G P+KKA + SA++ A +KKK S G ++
Sbjct: 322 ARAEAESPGGASESDQDGGHESPPKKKAVAWVSAKNPAPMRKKKKVSLGPVSYVLVDSED 381
Query: 610 G--------QAPTGSKAARGKKARRGRR 629
G + P + A +KA RG++
Sbjct: 382 GRKKPVMPKKGPGSRREASDQKAPRGQQ 409
>gi|11464969 paraneoplastic antigen MA2 [Homo sapiens]
Length = 364
Score = 108 bits (271), Expect = 1e-23
Identities = 55/133 (41%), Positives = 81/133 (60%)
Query: 1 MAMSLLQDWCRSLDVDAHRALLVTGIPEGLEQADVEAVLQPTLLPLGTFRLRHMKALMNE 60
MA++LL+DWCR + VD ++L+VTGIP E+A+++ VLQ TL LG +RL E
Sbjct: 1 MALALLEDWCRIMSVDEQKSLMVTGIPADFEEAEIQEVLQETLKSLGRYRLLGKIFRKQE 60
Query: 61 KAQAALVEFVEDVNHAAIPREIPGKDGVWRVLWKDRAQDTRVLRQMRRLLLDDGPTQAAE 120
A A L+E +ED + +AIP E+ GK GVW+V++K QDT L ++ L +G T +
Sbjct: 61 NANAVLLELLEDTDVSAIPSEVQGKGGVWKVIFKTPNQDTEFLERLNLFLEKEGQTVSGM 120
Query: 121 AGTPGEAPTPPAS 133
G+ PA+
Sbjct: 121 FRALGQEGVSPAT 133
>gi|52486265 paraneoplastic antigen MA1 [Homo sapiens]
Length = 353
Score = 104 bits (260), Expect = 2e-22
Identities = 60/140 (42%), Positives = 85/140 (60%), Gaps = 3/140 (2%)
Query: 1 MAMSLLQDWCRSLDVDAHRALLVTGIPEGLEQADVEAVLQPTLLPLGTFRLRHMKALMNE 60
MAM+LL+DWCR +DV++ RALLV GIP ++A++E LQ + P ++R+ E
Sbjct: 1 MAMTLLEDWCRGMDVNSQRALLVWGIPVNCDEAEIEETLQAAM-PQVSYRMLGRMFWREE 59
Query: 61 KAQAALVEFVEDVNHAAIPREIPGKDGVWRVLWKDRAQDTRVLRQMRRLLLDDGPTQAAE 120
A+AAL+E V++AAIPRE+PGK GVW+VL+K D L ++ L +G T
Sbjct: 60 NAKAALLELTGAVDYAAIPREMPGKGGVWKVLFKPPTSDAEFLERLHLFLAREGWTVQDV 119
Query: 121 AGTPG-EAPTP-PASETQAQ 138
A G + PTP P E A+
Sbjct: 120 ARVLGFQNPTPTPGPEMPAE 139
>gi|19923584 modulator of apoptosis 1 [Homo sapiens]
Length = 351
Score = 97.4 bits (241), Expect = 3e-20
Identities = 45/116 (38%), Positives = 68/116 (58%)
Query: 1 MAMSLLQDWCRSLDVDAHRALLVTGIPEGLEQADVEAVLQPTLLPLGTFRLRHMKALMNE 60
M + LL+DWCR +D++ +ALL+ GI + A++E LQ L PLG +RL +E
Sbjct: 1 MTLRLLEDWCRGMDMNPRKALLIAGISQSCSVAEIEEALQAGLAPLGEYRLLGRMFRRDE 60
Query: 61 KAQAALVEFVEDVNHAAIPREIPGKDGVWRVLWKDRAQDTRVLRQMRRLLLDDGPT 116
+ ALV + +HA +P+EIPGK G+WRV++K D L ++ L +G T
Sbjct: 61 NRKVALVGLTAETSHALVPKEIPGKGGIWRVIFKPPDPDNTFLSRLNEFLAGEGMT 116
>gi|169216514 PREDICTED: similar to paraneoplastic antigen MA2 [Homo
sapiens]
Length = 340
Score = 91.7 bits (226), Expect = 2e-18
Identities = 66/203 (32%), Positives = 95/203 (46%), Gaps = 18/203 (8%)
Query: 1 MAMSLLQDWCRSLDVDAHRALLVTGIPEGLEQADVEAVLQPTLLPLGTFRLRHMKALMNE 60
MA+++L+DWCR + V+A R+LL+ IP+ E+ + + ++ L PLG +R+
Sbjct: 1 MALAMLRDWCRRMGVNAERSLLILDIPDDCEEHEFQEAVRAALSPLGRYRVLIKVFRKEL 60
Query: 61 KAQAALVEFVEDVNHAAIPREIPGKDGVWRVLWKDRAQDTRVLRQMRRLLLDDGPTQAAE 120
A+AALVEF E +N + IPR+I GK G W+V+ +A D D P++A
Sbjct: 61 GARAALVEFAEGLNQSLIPRQIAGKGGPWKVISLPQALDAE---------FQDIPSEAGA 111
Query: 121 AGTPGEAPTPPAS-------ETQAQDSG--EVTGQAGSLLGAARNPRRGRRGRRNRTRRN 171
AG EA A+ ET A G E TG+ GS A G
Sbjct: 112 AGEEEEAGDGGAAGAAGAIGETGAVGKGEAEATGEGGSASEAEGAGEGGAGDELRVAEEA 171
Query: 172 RLTQKGKKRSRGGRPSAPARSEA 194
R + +G G A A EA
Sbjct: 172 RESDEGAAGDTGPAGEAEAVGEA 194
Score = 30.4 bits (67), Expect = 5.2
Identities = 35/129 (27%), Positives = 44/129 (34%), Gaps = 6/129 (4%)
Query: 512 EEESEDTESEAS---EPEDRASRKPRAKRARTAPRGLTPAG-APPTASGARKTRAGGRGR 567
+ E +D SEA E E+ G G A T G + A G G
Sbjct: 99 DAEFQDIPSEAGAAGEEEEAGDGGAAGAAGAIGETGAVGKGEAEATGEGGSASEAEGAGE 158
Query: 568 GRGVTPEKKAGSRGSAQDDAAGSRKKKGSAGAGAHARA-GEAKGQAPTGSKA-ARGKKAR 625
G + A + + AAG G A A A A GEA G+ ARG
Sbjct: 159 GGAGDELRVAEEARESDEGAAGDTGPAGEAEAVGEAGAVGEAGAAGEAGAVGEARGTNVT 218
Query: 626 RGRRLPPKC 634
R P +C
Sbjct: 219 RAWVQPRRC 227
>gi|169216749 PREDICTED: similar to Putative paraneoplastic
antigen-like protein 6B-like protein [Homo sapiens]
Length = 340
Score = 91.7 bits (226), Expect = 2e-18
Identities = 66/203 (32%), Positives = 95/203 (46%), Gaps = 18/203 (8%)
Query: 1 MAMSLLQDWCRSLDVDAHRALLVTGIPEGLEQADVEAVLQPTLLPLGTFRLRHMKALMNE 60
MA+++L+DWCR + V+A R+LL+ IP+ E+ + + ++ L PLG +R+
Sbjct: 1 MALAMLRDWCRRMGVNAERSLLILDIPDDCEEHEFQEAVRAALSPLGRYRVLIKVFRKEL 60
Query: 61 KAQAALVEFVEDVNHAAIPREIPGKDGVWRVLWKDRAQDTRVLRQMRRLLLDDGPTQAAE 120
A+AALVEF E +N + IPR+I GK G W+V+ +A D D P++A
Sbjct: 61 GARAALVEFAEGLNQSLIPRQIAGKGGPWKVISLPQALDAE---------FQDIPSEAGA 111
Query: 121 AGTPGEAPTPPAS-------ETQAQDSG--EVTGQAGSLLGAARNPRRGRRGRRNRTRRN 171
AG EA A+ ET A G E TG+ GS A G
Sbjct: 112 AGEEEEAGDGGAAGAAGAIGETGAVGKGEAEATGEGGSASEAEGAGEGGAGDELRVAEEA 171
Query: 172 RLTQKGKKRSRGGRPSAPARSEA 194
R + +G G A A EA
Sbjct: 172 RESDEGAAGDTGPAGEAEAVGEA 194
Score = 30.4 bits (67), Expect = 5.2
Identities = 35/129 (27%), Positives = 44/129 (34%), Gaps = 6/129 (4%)
Query: 512 EEESEDTESEAS---EPEDRASRKPRAKRARTAPRGLTPAG-APPTASGARKTRAGGRGR 567
+ E +D SEA E E+ G G A T G + A G G
Sbjct: 99 DAEFQDIPSEAGAAGEEEEAGDGGAAGAAGAIGETGAVGKGEAEATGEGGSASEAEGAGE 158
Query: 568 GRGVTPEKKAGSRGSAQDDAAGSRKKKGSAGAGAHARA-GEAKGQAPTGSKA-ARGKKAR 625
G + A + + AAG G A A A A GEA G+ ARG
Sbjct: 159 GGAGDELRVAEEARESDEGAAGDTGPAGEAEAVGEAGAVGEAGAAGEAGAVGEARGTNVT 218
Query: 626 RGRRLPPKC 634
R P +C
Sbjct: 219 RAWVQPRRC 227
>gi|142976816 paraneoplastic cancer-testis-brain antigen [Homo
sapiens]
Length = 463
Score = 90.9 bits (224), Expect = 3e-18
Identities = 45/116 (38%), Positives = 66/116 (56%)
Query: 1 MAMSLLQDWCRSLDVDAHRALLVTGIPEGLEQADVEAVLQPTLLPLGTFRLRHMKALMNE 60
M ++LLQDWCR ++ R +L+ GIPE + + E LQ LG +R+ E
Sbjct: 1 MPLTLLQDWCRGEHLNTRRCMLILGIPEDCGEDEFEETLQEACRHLGRYRVIGRMFRREE 60
Query: 61 KAQAALVEFVEDVNHAAIPREIPGKDGVWRVLWKDRAQDTRVLRQMRRLLLDDGPT 116
AQA L+E +D+++A +PREIPGK G W V+ K R D L ++ R L ++ T
Sbjct: 61 NAQAILLELAQDIDYALLPREIPGKGGPWEVIVKPRNSDGEFLNRLNRFLEEERRT 116
>gi|156766066 paraneoplastic antigen like 5 [Homo sapiens]
Length = 448
Score = 88.6 bits (218), Expect = 2e-17
Identities = 43/133 (32%), Positives = 70/133 (52%)
Query: 1 MAMSLLQDWCRSLDVDAHRALLVTGIPEGLEQADVEAVLQPTLLPLGTFRLRHMKALMNE 60
MA++LL+DWC+ +D+D +ALL+ GIP + +++ ++ L PL +R+ +
Sbjct: 1 MALTLLEDWCKGMDMDPRKALLIVGIPMECSEVEIQDTVKAGLQPLCAYRVLGRMFRRED 60
Query: 61 KAQAALVEFVEDVNHAAIPREIPGKDGVWRVLWKDRAQDTRVLRQMRRLLLDDGPTQAAE 120
A+A +E + VN+ +P IPGK G W V+ K R D L ++ L D+G +
Sbjct: 61 NAKAVFIELADTVNYTTLPSHIPGKGGSWEVVVKPRNPDDEFLSRLNYFLKDEGRSMTDV 120
Query: 121 AGTPGEAPTPPAS 133
A G P S
Sbjct: 121 ARALGCCSLPAES 133
>gi|156766064 paraneoplastic antigen like 5 [Homo sapiens]
Length = 448
Score = 88.6 bits (218), Expect = 2e-17
Identities = 43/133 (32%), Positives = 70/133 (52%)
Query: 1 MAMSLLQDWCRSLDVDAHRALLVTGIPEGLEQADVEAVLQPTLLPLGTFRLRHMKALMNE 60
MA++LL+DWC+ +D+D +ALL+ GIP + +++ ++ L PL +R+ +
Sbjct: 1 MALTLLEDWCKGMDMDPRKALLIVGIPMECSEVEIQDTVKAGLQPLCAYRVLGRMFRRED 60
Query: 61 KAQAALVEFVEDVNHAAIPREIPGKDGVWRVLWKDRAQDTRVLRQMRRLLLDDGPTQAAE 120
A+A +E + VN+ +P IPGK G W V+ K R D L ++ L D+G +
Sbjct: 61 NAKAVFIELADTVNYTTLPSHIPGKGGSWEVVVKPRNPDDEFLSRLNYFLKDEGRSMTDV 120
Query: 121 AGTPGEAPTPPAS 133
A G P S
Sbjct: 121 ARALGCCSLPAES 133
>gi|24308384 paraneoplastic antigen like 5 [Homo sapiens]
Length = 448
Score = 88.6 bits (218), Expect = 2e-17
Identities = 43/133 (32%), Positives = 70/133 (52%)
Query: 1 MAMSLLQDWCRSLDVDAHRALLVTGIPEGLEQADVEAVLQPTLLPLGTFRLRHMKALMNE 60
MA++LL+DWC+ +D+D +ALL+ GIP + +++ ++ L PL +R+ +
Sbjct: 1 MALTLLEDWCKGMDMDPRKALLIVGIPMECSEVEIQDTVKAGLQPLCAYRVLGRMFRRED 60
Query: 61 KAQAALVEFVEDVNHAAIPREIPGKDGVWRVLWKDRAQDTRVLRQMRRLLLDDGPTQAAE 120
A+A +E + VN+ +P IPGK G W V+ K R D L ++ L D+G +
Sbjct: 61 NAKAVFIELADTVNYTTLPSHIPGKGGSWEVVVKPRNPDDEFLSRLNYFLKDEGRSMTDV 120
Query: 121 AGTPGEAPTPPAS 133
A G P S
Sbjct: 121 ARALGCCSLPAES 133
>gi|239746972 PREDICTED: hypothetical protein XP_002343899 [Homo
sapiens]
Length = 399
Score = 87.0 bits (214), Expect = 5e-17
Identities = 43/103 (41%), Positives = 61/103 (59%)
Query: 1 MAMSLLQDWCRSLDVDAHRALLVTGIPEGLEQADVEAVLQPTLLPLGTFRLRHMKALMNE 60
MA+++LQDWCR + V+A R LL+ GIPE + A+ + L+ L P+G F + +
Sbjct: 1 MAVTMLQDWCRWMGVNARRGLLILGIPEDCDDAEFQESLEAALRPMGHFTVLGKAFREED 60
Query: 61 KAQAALVEFVEDVNHAAIPREIPGKDGVWRVLWKDRAQDTRVL 103
A AALVE +VN+A +PREIPG G W V++ R L
Sbjct: 61 NATAALVELDREVNYALVPREIPGTGGPWNVVFVPRCSGEEFL 103
>gi|239746970 PREDICTED: hypothetical protein XP_002343898 [Homo
sapiens]
Length = 399
Score = 87.0 bits (214), Expect = 5e-17
Identities = 43/103 (41%), Positives = 61/103 (59%)
Query: 1 MAMSLLQDWCRSLDVDAHRALLVTGIPEGLEQADVEAVLQPTLLPLGTFRLRHMKALMNE 60
MA+++LQDWCR + V+A R LL+ GIPE + A+ + L+ L P+G F + +
Sbjct: 1 MAVTMLQDWCRWMGVNARRGLLILGIPEDCDDAEFQESLEAALRPMGHFTVLGKAFREED 60
Query: 61 KAQAALVEFVEDVNHAAIPREIPGKDGVWRVLWKDRAQDTRVL 103
A AALVE +VN+A +PREIPG G W V++ R L
Sbjct: 61 NATAALVELDREVNYALVPREIPGTGGPWNVVFVPRCSGEEFL 103
>gi|239746974 PREDICTED: hypothetical protein XP_002343900 [Homo
sapiens]
Length = 399
Score = 86.7 bits (213), Expect = 6e-17
Identities = 43/103 (41%), Positives = 61/103 (59%)
Query: 1 MAMSLLQDWCRSLDVDAHRALLVTGIPEGLEQADVEAVLQPTLLPLGTFRLRHMKALMNE 60
MA+++LQDWCR + V+A R LL+ GIPE + A+ + L+ L P+G F + +
Sbjct: 1 MAVTMLQDWCRWMGVNARRGLLILGIPEDCDDAEFQESLEAALRPMGHFTVLGKVFREED 60
Query: 61 KAQAALVEFVEDVNHAAIPREIPGKDGVWRVLWKDRAQDTRVL 103
A AALVE +VN+A +PREIPG G W V++ R L
Sbjct: 61 NATAALVELDREVNYALVPREIPGTGGPWNVVFVPRCSGEEFL 103
>gi|187607308 paraneoplastic antigen like 6A [Homo sapiens]
Length = 399
Score = 86.7 bits (213), Expect = 6e-17
Identities = 43/103 (41%), Positives = 61/103 (59%)
Query: 1 MAMSLLQDWCRSLDVDAHRALLVTGIPEGLEQADVEAVLQPTLLPLGTFRLRHMKALMNE 60
MA+++LQDWCR + V+A R LL+ GIPE + A+ + L+ L P+G F + +
Sbjct: 1 MAVTMLQDWCRWMGVNARRGLLILGIPEDCDDAEFQESLEAALRPMGHFTVLGKVFREED 60
Query: 61 KAQAALVEFVEDVNHAAIPREIPGKDGVWRVLWKDRAQDTRVL 103
A AALVE +VN+A +PREIPG G W V++ R L
Sbjct: 61 NATAALVELDREVNYALVPREIPGTGGPWNVVFVPRCSGEEFL 103
>gi|169217313 PREDICTED: similar to paraneoplastic antigen MA1 [Homo
sapiens]
Length = 601
Score = 81.3 bits (199), Expect = 3e-15
Identities = 38/92 (41%), Positives = 60/92 (65%)
Query: 1 MAMSLLQDWCRSLDVDAHRALLVTGIPEGLEQADVEAVLQPTLLPLGTFRLRHMKALMNE 60
+A+++LQDWCR + V+A R+LL+ IP+ E+ + + ++ L PLG +R+
Sbjct: 191 IALAMLQDWCRRMGVNAERSLLILDIPDDCEEHEFQEAVRAALSPLGRYRVLIKVFRKEL 250
Query: 61 KAQAALVEFVEDVNHAAIPREIPGKDGVWRVL 92
A+AALVEF E +N + IPR+I GK G W+V+
Sbjct: 251 GARAALVEFAEGLNQSLIPRQIAGKGGPWKVI 282
>gi|169216507 PREDICTED: similar to hCG1645335 [Homo sapiens]
Length = 409
Score = 81.3 bits (199), Expect = 3e-15
Identities = 39/108 (36%), Positives = 67/108 (62%), Gaps = 1/108 (0%)
Query: 1 MAMSLLQDWCRSLDVDAHRALLVTGIPEGLEQADVEAVLQPTLLPLGTFRLRHMKALMNE 60
MA+++L+DWCR + +A R+LL+ GIP+ ++ + + ++ L PLG +R+
Sbjct: 1 MALAMLRDWCRWMGANAERSLLILGIPDDCKEHEFQEAVRAALSPLGRYRVLTKHFRKEL 60
Query: 61 KAQAALVEFVEDVNHAAIPREIPGKDGVWRVLWKDR-AQDTRVLRQMR 107
A+AALVEF E +N + IP +IPG G W+V++ + + R R++R
Sbjct: 61 GAKAALVEFAEYLNRSLIPHQIPGNGGPWKVIFLPQPVLENRAYRELR 108
>gi|169216516 PREDICTED: similar to paraneoplastic antigen MA1 [Homo
sapiens]
Length = 541
Score = 81.3 bits (199), Expect = 3e-15
Identities = 38/92 (41%), Positives = 60/92 (65%)
Query: 1 MAMSLLQDWCRSLDVDAHRALLVTGIPEGLEQADVEAVLQPTLLPLGTFRLRHMKALMNE 60
+A+++LQDWCR + V+A R+LL+ IP+ E+ + + ++ L PLG +R+
Sbjct: 131 IALAMLQDWCRRMGVNAERSLLILDIPDDCEEHEFQEAVRAALSPLGRYRVLIKVFRKEL 190
Query: 61 KAQAALVEFVEDVNHAAIPREIPGKDGVWRVL 92
A+AALVEF E +N + IPR+I GK G W+V+
Sbjct: 191 GARAALVEFAEGLNQSLIPRQIAGKGGPWKVI 222
>gi|169216732 PREDICTED: similar to hCG1645335 [Homo sapiens]
Length = 409
Score = 81.3 bits (199), Expect = 3e-15
Identities = 39/108 (36%), Positives = 67/108 (62%), Gaps = 1/108 (0%)
Query: 1 MAMSLLQDWCRSLDVDAHRALLVTGIPEGLEQADVEAVLQPTLLPLGTFRLRHMKALMNE 60
MA+++L+DWCR + +A R+LL+ GIP+ ++ + + ++ L PLG +R+
Sbjct: 1 MALAMLRDWCRWMGANAERSLLILGIPDDCKEHEFQEAVRAALSPLGRYRVLTKHFRKEL 60
Query: 61 KAQAALVEFVEDVNHAAIPREIPGKDGVWRVLWKDR-AQDTRVLRQMR 107
A+AALVEF E +N + IP +IPG G W+V++ + + R R++R
Sbjct: 61 GAKAALVEFAEYLNRSLIPHQIPGNGGPWKVIFLPQPVLENRAYRELR 108
>gi|239746976 PREDICTED: similar to paraneoplastic antigen MA1 [Homo
sapiens]
Length = 601
Score = 81.3 bits (199), Expect = 3e-15
Identities = 38/92 (41%), Positives = 60/92 (65%)
Query: 1 MAMSLLQDWCRSLDVDAHRALLVTGIPEGLEQADVEAVLQPTLLPLGTFRLRHMKALMNE 60
+A+++LQDWCR + V+A R+LL+ IP+ E+ + + ++ L PLG +R+
Sbjct: 191 IALAMLQDWCRRMGVNAERSLLILDIPDDCEEHEFQEAVRAALSPLGRYRVLIKVFRKEL 250
Query: 61 KAQAALVEFVEDVNHAAIPREIPGKDGVWRVL 92
A+AALVEF E +N + IPR+I GK G W+V+
Sbjct: 251 GARAALVEFAEGLNQSLIPRQIAGKGGPWKVI 282
>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
[Homo sapiens]
Length = 1451
Score = 50.1 bits (118), Expect = 6e-06
Identities = 100/501 (19%), Positives = 179/501 (35%), Gaps = 61/501 (12%)
Query: 116 TQAAEAGTPGEAPTPPASETQAQDSGEVTGQAGSLLGAARNPRRGRRGRRNRTRRNRLTQ 175
++++E G+ E P + +Q + S ++ + AA P +G G+
Sbjct: 270 SESSEEGSESEEEAPAGTRSQVKASEKILQ-----VRAASAPAKGTPGKGATPAPPGKAG 324
Query: 176 KGKKRSRGGRPSAPARSEAEDSSDESLGIVIEEIDQGDLSGEEDQSALYATLQAAARELV 235
+++ G+P + S +E+SSD EE+ A A LQA A
Sbjct: 325 AVASQTKAGKPEEDSESSSEESSDS----------------EEETPAAKALLQAKASGKT 368
Query: 236 RQWAPCNSEGEEDGPREFLALVTVTDKSKKEEAEKEPAGAESIRLNTKEDKNGVPDLVAL 295
Q ++ +E PR+ A + PA A++ +ED +
Sbjct: 369 SQVGAASAPAKES-PRKGAA--------PAPPGKTGPAVAKAQAGKREEDSQSSSE---- 415
Query: 296 LAVRDTPDEEPVDSDTSESDSQESGDQETEELDNPEFVAIVAYTDPSDPWAREEMLKIAS 355
D+ +E P + S Q + ++P A A + P A + +++
Sbjct: 416 --ESDSEEEAPAQAKPSGKAPQVRAASAPAK-ESPRKGAAPAPPRKTGPAAAQ--VQVGK 470
Query: 356 VIESLGWSDEKDKRDPLRQVLSVMSKDTNGTRVKVEEAGREVDAVVLRKAGDDGDLRECI 415
E S E+ D R+ L+ M+ +V+ G+ G G L +
Sbjct: 471 QEEDSRSSSEESDSD--REALAAMNA------AQVKPLGKSPQVKPASTMGM-GPLGKGA 521
Query: 416 STLAQPDLPPQAKKAGRGLFGGWSEHREDE------GGLLELVALLAAQDMAEVMKEEKE 469
+ + P A G + SE +E G + VA + + +++ +
Sbjct: 522 GPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPT 581
Query: 470 NAWEGGKYKYPKGKLGEVLALLAARENMGSNEGSEEASDEQSEEESEDTESEASEPEDRA 529
++ G P K G V + A + M ++E SEE+SD EE+ + A A
Sbjct: 582 SSPAKG----PPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKP--A 635
Query: 530 SRKPRAKRARTAPRGLTPAGAPPTASGARKTRAGGRGRG-RGVTPEKKAGSRGSAQDDAA 588
+ P+ K A P G + R G G +P G++ A+D ++
Sbjct: 636 LKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSS 695
Query: 589 GSRKKKGSAGAGAHARAGEAK 609
G G+AK
Sbjct: 696 SEESDSEEEKTGLAVTVGQAK 716
Score = 47.4 bits (111), Expect = 4e-05
Identities = 41/151 (27%), Positives = 62/151 (41%), Gaps = 14/151 (9%)
Query: 480 PKGKLGEVLALLAARENMGSNEGSEEASDEQSEEESEDTESEASEPEDRASRKPRAKRAR 539
P GK G V A++ G E E+S E+S + E+T + + + +AS K A
Sbjct: 319 PPGKAGAV----ASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAA 374
Query: 540 TAPRGLTP-AGAPPTASGARKTRAGGRGRGRGVTPEKKAGSRGSAQDDAAGSRKKKGSA- 597
+AP +P GA P G G+ + + ++++A K G A
Sbjct: 375 SAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAP 434
Query: 598 ---GAGAHARAGEAKGQAP-----TGSKAAR 620
A A A+ KG AP TG AA+
Sbjct: 435 QVRAASAPAKESPRKGAAPAPPRKTGPAAAQ 465
Score = 45.8 bits (107), Expect = 1e-04
Identities = 41/164 (25%), Positives = 68/164 (41%), Gaps = 16/164 (9%)
Query: 482 GKLGEVLALLAARENMGSNEGSEEASDEQSEEESEDTESEA---SEPEDRASRKPRAKRA 538
GK+G+V + + + + +S EE ++E EA + + +AS K RA
Sbjct: 243 GKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRA 302
Query: 539 RTAP------RGLTPAGAPPTASGARKTRAGGRGRGRGVTPEKKAGS-------RGSAQD 585
+AP +G TPA + A +T+AG + E+ + S + Q
Sbjct: 303 ASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQA 362
Query: 586 DAAGSRKKKGSAGAGAHARAGEAKGQAPTGSKAARGKKARRGRR 629
A+G + G+A A A + AP G KA+ G+R
Sbjct: 363 KASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKR 406
Score = 45.1 bits (105), Expect = 2e-04
Identities = 111/515 (21%), Positives = 180/515 (34%), Gaps = 87/515 (16%)
Query: 123 TPGEAPTPPASETQAQDSGEVTGQAGSL--LGAARNPRRGRRGRRNRTRRNRLTQKGKKR 180
+P ++ P A+ T + T + GS+ GAA P G+ + + + + +
Sbjct: 156 SPRKSAEPSANTTLVSE----TEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETD 211
Query: 181 SRGGRPSAPARSEAED-SSDESLGIVIEEIDQ--GDLSGEEDQSALYATLQAAARELVRQ 237
G PA+ +A S+ ES GD++ + AL +A E +
Sbjct: 212 VEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESE 271
Query: 238 WAPCNSEGEEDGPREFLALVTVTDKSKKEEAEKEPAGAESIRLNTKEDKNGVPDLVALLA 297
+ SE EE+ P + V ++K + A PA + T G VA
Sbjct: 272 SSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPP-GKAGAVASQT 330
Query: 298 VRDTPDEEPVDSDTSESDSQESGDQETEELDNPEFVAIVAYTDPSDPWAREEMLKIASVI 357
P+E+ SES S+ES D E E P A++ K +
Sbjct: 331 KAGKPEED------SESSSEESSDSEEE---TPAAKALL-------------QAKASGKT 368
Query: 358 ESLGWSDEKDKRDPLRQVLSVMSKDTNGTRVKVEEAGREVDAVVLRKAGDDGDLRECIST 417
+G + K P + T K + RE D+ + + ++ D E
Sbjct: 369 SQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDS---QSSSEESDSEE---- 421
Query: 418 LAQPDLPPQAKKAGRGLFGGWSEHREDEGGLLELVALLAAQDMAEVMKEEKENAWEGGKY 477
+ P QAK +G+ A + KE+ +G
Sbjct: 422 ----EAPAQAKPSGK------------------------APQVRAASAPAKESPRKGAAP 453
Query: 478 KYPKGKLGEVLALLAARENMGSNEGSEEASDEQSEEESEDTESEASEPEDRASRKPRAKR 537
P+ K G AA+ +G E D +S E D++ EA + A KP K
Sbjct: 454 APPR-KTGPA----AAQVQVGKQE-----EDSRSSSEESDSDREALAAMNAAQVKPLGKS 503
Query: 538 ARTAPRGLTPAGAPPTASGARKTRAGGRGRGRGVTPEKKAG-----SRGSAQDDAAGSRK 592
+ P + G P GA G G TP + G S S+++ + S
Sbjct: 504 PQVKP--ASTMGMGPLGKGAGPVPPGKVG---PATPSAQVGKWEEDSESSSEESSDSSDG 558
Query: 593 KKGSAGAGAHARAGEAKGQAPTGSKAARGKKARRG 627
+ +A A A ++ QA S A+G + G
Sbjct: 559 EVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAG 593
Score = 35.8 bits (81), Expect = 0.12
Identities = 38/159 (23%), Positives = 58/159 (36%), Gaps = 18/159 (11%)
Query: 480 PKGKLGEVLALLAARENMGSNEGSEEASDEQSEEESE---DTESEASEPEDRASRKPRAK 536
P GK G +A A G E ++S E+S+ E E + P+ RA+ P
Sbjct: 390 PPGKTGPAVAKAQA----GKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAP--- 442
Query: 537 RARTAPR-GLTPAGAPPTASGARKTRAGGRGRGRGVTPEKKAGSR------GSAQDDAAG 589
A+ +PR G PA T A + + G + + E+ R +AQ G
Sbjct: 443 -AKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLG 501
Query: 590 SRKKKGSAGAGAHARAGEAKGQAPTGSKAARGKKARRGR 628
+ A G+ G P G A+ G+
Sbjct: 502 KSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGK 540
Score = 35.4 bits (80), Expect = 0.16
Identities = 37/140 (26%), Positives = 56/140 (40%), Gaps = 21/140 (15%)
Query: 510 QSEEESEDTESEASEP--EDRASRKPR-------------AKRARTAP---RGLTP---A 548
Q++ SEDT S + E E + S KP A++A AP +TP
Sbjct: 195 QADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKG 254
Query: 549 GAPPTASGARKTRAGGRGRGRGVTPEKKAGSRGSAQDDAAGSRKKKGSAGAGAHARAGEA 608
GA P A A+K G E++A + +Q A+ + +A A A G+
Sbjct: 255 GALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKG 314
Query: 609 KGQAPTGSKAARGKKARRGR 628
AP G A + + G+
Sbjct: 315 ATPAPPGKAGAVASQTKAGK 334
Score = 35.0 bits (79), Expect = 0.21
Identities = 107/510 (20%), Positives = 165/510 (32%), Gaps = 92/510 (18%)
Query: 115 PTQAAEAGTPGEAPTPPASETQAQDSGEVTGQAGSLLGAARNPRRGR---RGRRNRTRRN 171
P+ PG+ T A Q S + RNP+ RG +
Sbjct: 800 PSAKGTISAPGKVVTAAAQAKQRSPS--------KVKPPVRNPQNSTVLARGPASVPSVG 851
Query: 172 RLTQKGKKRSRGGRPSAPARSEAEDSSDESLGIVIEEIDQGDLSGEEDQSALYATLQAAA 231
+ + G + + E DS +E+ E + Q SG+ Q + A L A A
Sbjct: 852 KAVATAAQAQTGPEEDSGSSEEESDSEEEA-----ETLAQVKPSGKTHQ--IRAAL-APA 903
Query: 232 RELVRQWAPCNSEGEEDGPREFLALVTVTDKSKKEEAEKE---PAGAES--------IRL 280
+E R+ A G+ GP A S EE++ + PA S I +
Sbjct: 904 KESPRKGAAPTPPGKT-GPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFV 962
Query: 281 NTKEDKNGVPDLVALLAVRDTPDEEPVDSDTSESDSQESGDQET---EELDNPEFVAIVA 337
+ G A TP + T+ S S ES D++ + P V
Sbjct: 963 DPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVV 1022
Query: 338 YTDPSDPWA--REEMLKIASVIESLGWSDEKDKRDPLRQV--------------LSVMSK 381
+ P + M +S ES SD K + P QV SV +K
Sbjct: 1023 TMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVDSAVGTLPATSPQSTSVQAK 1082
Query: 382 DTNGTRV-KVEEAGREVDAVVLRKAGDDGDLRECISTLAQPDLPPQAKKAGRGLFGGWSE 440
TN R K+ E + A + D D + S + PQ K+ L G
Sbjct: 1083 GTNKLRKPKLPEVQQATKAP--ESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLVGPTPS 1140
Query: 441 HREDEGGLLELVALLAAQDMAEVMKEEKENAWEGGKYKYPKGKLGEVLALLAARENMGSN 500
E L+E A +++D + +LL+ G
Sbjct: 1141 RTET---LVEETAAESSEDDVVAPSQ----------------------SLLSGYMTPGLT 1175
Query: 501 EGSEEASDEQSEEESEDTESEASEPEDRASRKPRAKRARTAPRGLTPAGAPPTASGARKT 560
+ +AS + +S + S +D K AK P A+G
Sbjct: 1176 PANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAK--------------PQQAAGMLSP 1221
Query: 561 RAGGRGRGRGVTPEKKAGSRGSAQDDAAGS 590
+ GG+ G TP+K + A + A +
Sbjct: 1222 KTGGKEAASGTTPQKSRKPKKGAGNPQAST 1251
Score = 34.7 bits (78), Expect = 0.27
Identities = 34/116 (29%), Positives = 48/116 (41%), Gaps = 12/116 (10%)
Query: 509 EQSEEESEDTESEASEPEDRASRKPRAKRARTAPRGLTPAGAPPTASGARKTRAGGRGRG 568
EQ ++ DT E+S RK R R G PA P + +K AG G
Sbjct: 1287 EQERKKVVDTTKESS-------RKGWESRKRKLS-GDQPAARTPRSKKKKKLGAGEGGEA 1338
Query: 569 RGVTPEKKAG-SRGSAQDDAAGS--RKKKGSAGAGAHARAGEAKGQAPTGSKAARG 621
V+PEK + S+G A+ D A ++KKG G+ E + + G G
Sbjct: 1339 -SVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEG 1393
Score = 33.5 bits (75), Expect = 0.61
Identities = 45/148 (30%), Positives = 64/148 (43%), Gaps = 19/148 (12%)
Query: 481 KGKLGEVLALLAARENMGSNEGSEEASDEQSEEESE---------DTESEASEPEDRASR 531
K K E AL A + + + E+S+E+ E E+E T S + +S
Sbjct: 62 KRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSM 121
Query: 532 KPRAKRARTAPRGLTPAGAPPTASGARKTRAGGRGRGRGVTPEKKAGSRGSAQDDAAGSR 591
K +AK A T G T P A+G KT A G +P K A SA
Sbjct: 122 KEKAK-AETEKAGKTGNSMPHPATG--KTVANLLS---GKSPRKSA--EPSANTTLVSET 173
Query: 592 KKKGSAGA-GAHARAG-EAKGQAPTGSK 617
+++GS A GA A+ G + GQA + S+
Sbjct: 174 EEEGSVPAFGAAAKPGMVSAGQADSSSE 201
Score = 33.1 bits (74), Expect = 0.80
Identities = 114/566 (20%), Positives = 192/566 (33%), Gaps = 79/566 (13%)
Query: 112 DDGPTQAAEAGTPGEAPTPPASET-QAQDSGEVTGQAGSLLGAARNPRRGRRGRRNRTRR 170
++ ++E + E TP A QA+ SG+ + + A +PR+G
Sbjct: 336 EEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAP------- 388
Query: 171 NRLTQKGKKRSRGGRPSAPARSEAEDSSDESLGIVIEEIDQGDLSGEEDQ------SALY 224
GK + A R E SS E E Q SG+ Q A
Sbjct: 389 ---APPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKE 445
Query: 225 ATLQAAARELVRQWAPC--------------NSEGEEDGPREFLALVTVTD-KSKKEEAE 269
+ + AA R+ P +S E D RE LA + K + +
Sbjct: 446 SPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQ 505
Query: 270 KEPAGAESIRLNTKEDKNGVPDLVALLAVRDTPDEEPVDSDTSESDSQESGDQETEELDN 329
+PA + K P V + DS++S +S +S D E
Sbjct: 506 VKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVA 565
Query: 330 P---EFVAIVAYTDPSDPWAREEMLKIASVIESLGWSDEKDKRDPLRQVLSVMSKDTNGT 386
P + + + P+ A+ K V + D + S + +
Sbjct: 566 PAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSE---------SSEESSD 616
Query: 387 RVKVEEAGREVDAVVLRKAGDDGDLREC---ISTLAQPDLPP------QAKKAGRG---- 433
EEA + A + A + C +T A + P +KAG
Sbjct: 617 SADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPA 676
Query: 434 -----LFGGWSEHREDEGGLLELVALLAAQDMAEVMKEEKENAWEGGKYKYP----KGKL 484
+ GG ED E + +A + + K + +G + K KG L
Sbjct: 677 GSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAK-SVGKGLQVKAASVPVKGSL 735
Query: 485 GEVLALLAAREN---MGSNEGSEEASDEQSEEESEDTESEASEPEDRASRK-------PR 534
G+ A + + + + ++ E SEEES+ E+ AS + + S K P
Sbjct: 736 GQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPA 795
Query: 535 AKRARTAPRGLTPAGAPPTASGARKTRAGGRGRGRGVTPEKKAG-SRGSAQDDAAGSR-K 592
A RA +A ++ G TA+ K R+ + + P+ +RG A + G
Sbjct: 796 AARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVA 855
Query: 593 KKGSAGAGAHARAGEAKGQAPTGSKA 618
A G +G ++ ++ + +A
Sbjct: 856 TAAQAQTGPEEDSGSSEEESDSEEEA 881
Score = 32.7 bits (73), Expect = 1.0
Identities = 35/170 (20%), Positives = 62/170 (36%), Gaps = 24/170 (14%)
Query: 445 EGGLLELVALLAAQDMAEVM---KEEKENAWEGGKYKYPKGKLGEVLALLAARENMGSNE 501
+ +++++ L Q+ +V+ KE WE K K G+ A R
Sbjct: 1275 QASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLS----GDQPAARTPRSKKKKKL 1330
Query: 502 GSEEASDEQSEEESEDTESEASEPEDRASRKPRAKR---------ARTAPRGLTPAGAPP 552
G+ E + E T S+ D+AS + K+ A+ P G
Sbjct: 1331 GAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQKGMGT 1390
Query: 553 TASGAR--------KTRAGGRGRGRGVTPEKKAGSRGSAQDDAAGSRKKK 594
G + K ++ R + + +KK + S +D + S+KKK
Sbjct: 1391 VEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQKKK 1440
Score = 30.4 bits (67), Expect = 5.2
Identities = 33/138 (23%), Positives = 49/138 (35%), Gaps = 16/138 (11%)
Query: 502 GSEEASDEQSEEESEDTESEASEPEDRASRKPRAKRARTAPRGLTP----AGAPPTASGA 557
G EE S EE + E+E + + + S K RA AP +P A PP +G
Sbjct: 863 GPEEDSGSSEEESDSEEEAE-TLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGP 921
Query: 558 RKTRAGGRGRGRGVTPEKKAGSRGSAQDDAA-----------GSRKKKGSAGAGAHARAG 606
+AG + + E + A +A +R G A A A+A
Sbjct: 922 SAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAA 981
Query: 607 EAKGQAPTGSKAARGKKA 624
+A AR +
Sbjct: 982 STPRKARASESTARSSSS 999
>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
[Homo sapiens]
Length = 1488
Score = 50.1 bits (118), Expect = 6e-06
Identities = 100/501 (19%), Positives = 179/501 (35%), Gaps = 61/501 (12%)
Query: 116 TQAAEAGTPGEAPTPPASETQAQDSGEVTGQAGSLLGAARNPRRGRRGRRNRTRRNRLTQ 175
++++E G+ E P + +Q + S ++ + AA P +G G+
Sbjct: 270 SESSEEGSESEEEAPAGTRSQVKASEKILQ-----VRAASAPAKGTPGKGATPAPPGKAG 324
Query: 176 KGKKRSRGGRPSAPARSEAEDSSDESLGIVIEEIDQGDLSGEEDQSALYATLQAAARELV 235
+++ G+P + S +E+SSD EE+ A A LQA A
Sbjct: 325 AVASQTKAGKPEEDSESSSEESSDS----------------EEETPAAKALLQAKASGKT 368
Query: 236 RQWAPCNSEGEEDGPREFLALVTVTDKSKKEEAEKEPAGAESIRLNTKEDKNGVPDLVAL 295
Q ++ +E PR+ A + PA A++ +ED +
Sbjct: 369 SQVGAASAPAKES-PRKGAA--------PAPPGKTGPAVAKAQAGKREEDSQSSSE---- 415
Query: 296 LAVRDTPDEEPVDSDTSESDSQESGDQETEELDNPEFVAIVAYTDPSDPWAREEMLKIAS 355
D+ +E P + S Q + ++P A A + P A + +++
Sbjct: 416 --ESDSEEEAPAQAKPSGKAPQVRAASAPAK-ESPRKGAAPAPPRKTGPAAAQ--VQVGK 470
Query: 356 VIESLGWSDEKDKRDPLRQVLSVMSKDTNGTRVKVEEAGREVDAVVLRKAGDDGDLRECI 415
E S E+ D R+ L+ M+ +V+ G+ G G L +
Sbjct: 471 QEEDSRSSSEESDSD--REALAAMNA------AQVKPLGKSPQVKPASTMGM-GPLGKGA 521
Query: 416 STLAQPDLPPQAKKAGRGLFGGWSEHREDE------GGLLELVALLAAQDMAEVMKEEKE 469
+ + P A G + SE +E G + VA + + +++ +
Sbjct: 522 GPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPT 581
Query: 470 NAWEGGKYKYPKGKLGEVLALLAARENMGSNEGSEEASDEQSEEESEDTESEASEPEDRA 529
++ G P K G V + A + M ++E SEE+SD EE+ + A A
Sbjct: 582 SSPAKG----PPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKP--A 635
Query: 530 SRKPRAKRARTAPRGLTPAGAPPTASGARKTRAGGRGRG-RGVTPEKKAGSRGSAQDDAA 588
+ P+ K A P G + R G G +P G++ A+D ++
Sbjct: 636 LKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSS 695
Query: 589 GSRKKKGSAGAGAHARAGEAK 609
G G+AK
Sbjct: 696 SEESDSEEEKTGLAVTVGQAK 716
Score = 47.4 bits (111), Expect = 4e-05
Identities = 41/151 (27%), Positives = 62/151 (41%), Gaps = 14/151 (9%)
Query: 480 PKGKLGEVLALLAARENMGSNEGSEEASDEQSEEESEDTESEASEPEDRASRKPRAKRAR 539
P GK G V A++ G E E+S E+S + E+T + + + +AS K A
Sbjct: 319 PPGKAGAV----ASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAA 374
Query: 540 TAPRGLTP-AGAPPTASGARKTRAGGRGRGRGVTPEKKAGSRGSAQDDAAGSRKKKGSA- 597
+AP +P GA P G G+ + + ++++A K G A
Sbjct: 375 SAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAP 434
Query: 598 ---GAGAHARAGEAKGQAP-----TGSKAAR 620
A A A+ KG AP TG AA+
Sbjct: 435 QVRAASAPAKESPRKGAAPAPPRKTGPAAAQ 465
Score = 45.8 bits (107), Expect = 1e-04
Identities = 41/164 (25%), Positives = 68/164 (41%), Gaps = 16/164 (9%)
Query: 482 GKLGEVLALLAARENMGSNEGSEEASDEQSEEESEDTESEA---SEPEDRASRKPRAKRA 538
GK+G+V + + + + +S EE ++E EA + + +AS K RA
Sbjct: 243 GKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRA 302
Query: 539 RTAP------RGLTPAGAPPTASGARKTRAGGRGRGRGVTPEKKAGS-------RGSAQD 585
+AP +G TPA + A +T+AG + E+ + S + Q
Sbjct: 303 ASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQA 362
Query: 586 DAAGSRKKKGSAGAGAHARAGEAKGQAPTGSKAARGKKARRGRR 629
A+G + G+A A A + AP G KA+ G+R
Sbjct: 363 KASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKR 406
Score = 45.1 bits (105), Expect = 2e-04
Identities = 111/515 (21%), Positives = 180/515 (34%), Gaps = 87/515 (16%)
Query: 123 TPGEAPTPPASETQAQDSGEVTGQAGSL--LGAARNPRRGRRGRRNRTRRNRLTQKGKKR 180
+P ++ P A+ T + T + GS+ GAA P G+ + + + + +
Sbjct: 156 SPRKSAEPSANTTLVSE----TEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETD 211
Query: 181 SRGGRPSAPARSEAED-SSDESLGIVIEEIDQ--GDLSGEEDQSALYATLQAAARELVRQ 237
G PA+ +A S+ ES GD++ + AL +A E +
Sbjct: 212 VEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESE 271
Query: 238 WAPCNSEGEEDGPREFLALVTVTDKSKKEEAEKEPAGAESIRLNTKEDKNGVPDLVALLA 297
+ SE EE+ P + V ++K + A PA + T G VA
Sbjct: 272 SSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPP-GKAGAVASQT 330
Query: 298 VRDTPDEEPVDSDTSESDSQESGDQETEELDNPEFVAIVAYTDPSDPWAREEMLKIASVI 357
P+E+ SES S+ES D E E P A++ K +
Sbjct: 331 KAGKPEED------SESSSEESSDSEEE---TPAAKALL-------------QAKASGKT 368
Query: 358 ESLGWSDEKDKRDPLRQVLSVMSKDTNGTRVKVEEAGREVDAVVLRKAGDDGDLRECIST 417
+G + K P + T K + RE D+ + + ++ D E
Sbjct: 369 SQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDS---QSSSEESDSEE---- 421
Query: 418 LAQPDLPPQAKKAGRGLFGGWSEHREDEGGLLELVALLAAQDMAEVMKEEKENAWEGGKY 477
+ P QAK +G+ A + KE+ +G
Sbjct: 422 ----EAPAQAKPSGK------------------------APQVRAASAPAKESPRKGAAP 453
Query: 478 KYPKGKLGEVLALLAARENMGSNEGSEEASDEQSEEESEDTESEASEPEDRASRKPRAKR 537
P+ K G AA+ +G E D +S E D++ EA + A KP K
Sbjct: 454 APPR-KTGPA----AAQVQVGKQE-----EDSRSSSEESDSDREALAAMNAAQVKPLGKS 503
Query: 538 ARTAPRGLTPAGAPPTASGARKTRAGGRGRGRGVTPEKKAG-----SRGSAQDDAAGSRK 592
+ P + G P GA G G TP + G S S+++ + S
Sbjct: 504 PQVKP--ASTMGMGPLGKGAGPVPPGKVG---PATPSAQVGKWEEDSESSSEESSDSSDG 558
Query: 593 KKGSAGAGAHARAGEAKGQAPTGSKAARGKKARRG 627
+ +A A A ++ QA S A+G + G
Sbjct: 559 EVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAG 593
Score = 35.8 bits (81), Expect = 0.12
Identities = 38/159 (23%), Positives = 58/159 (36%), Gaps = 18/159 (11%)
Query: 480 PKGKLGEVLALLAARENMGSNEGSEEASDEQSEEESE---DTESEASEPEDRASRKPRAK 536
P GK G +A A G E ++S E+S+ E E + P+ RA+ P
Sbjct: 390 PPGKTGPAVAKAQA----GKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAP--- 442
Query: 537 RARTAPR-GLTPAGAPPTASGARKTRAGGRGRGRGVTPEKKAGSR------GSAQDDAAG 589
A+ +PR G PA T A + + G + + E+ R +AQ G
Sbjct: 443 -AKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLG 501
Query: 590 SRKKKGSAGAGAHARAGEAKGQAPTGSKAARGKKARRGR 628
+ A G+ G P G A+ G+
Sbjct: 502 KSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGK 540
Score = 35.4 bits (80), Expect = 0.16
Identities = 37/140 (26%), Positives = 56/140 (40%), Gaps = 21/140 (15%)
Query: 510 QSEEESEDTESEASEP--EDRASRKPR-------------AKRARTAP---RGLTP---A 548
Q++ SEDT S + E E + S KP A++A AP +TP
Sbjct: 195 QADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKG 254
Query: 549 GAPPTASGARKTRAGGRGRGRGVTPEKKAGSRGSAQDDAAGSRKKKGSAGAGAHARAGEA 608
GA P A A+K G E++A + +Q A+ + +A A A G+
Sbjct: 255 GALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKG 314
Query: 609 KGQAPTGSKAARGKKARRGR 628
AP G A + + G+
Sbjct: 315 ATPAPPGKAGAVASQTKAGK 334
Score = 34.7 bits (78), Expect = 0.27
Identities = 34/116 (29%), Positives = 48/116 (41%), Gaps = 12/116 (10%)
Query: 509 EQSEEESEDTESEASEPEDRASRKPRAKRARTAPRGLTPAGAPPTASGARKTRAGGRGRG 568
EQ ++ DT E+S RK R R G PA P + +K AG G
Sbjct: 1324 EQERKKVVDTTKESS-------RKGWESRKRKLS-GDQPAARTPRSKKKKKLGAGEGGEA 1375
Query: 569 RGVTPEKKAG-SRGSAQDDAAGS--RKKKGSAGAGAHARAGEAKGQAPTGSKAARG 621
V+PEK + S+G A+ D A ++KKG G+ E + + G G
Sbjct: 1376 -SVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEG 1430
Score = 33.5 bits (75), Expect = 0.61
Identities = 45/148 (30%), Positives = 64/148 (43%), Gaps = 19/148 (12%)
Query: 481 KGKLGEVLALLAARENMGSNEGSEEASDEQSEEESE---------DTESEASEPEDRASR 531
K K E AL A + + + E+S+E+ E E+E T S + +S
Sbjct: 62 KRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSM 121
Query: 532 KPRAKRARTAPRGLTPAGAPPTASGARKTRAGGRGRGRGVTPEKKAGSRGSAQDDAAGSR 591
K +AK A T G T P A+G KT A G +P K A SA
Sbjct: 122 KEKAK-AETEKAGKTGNSMPHPATG--KTVANLLS---GKSPRKSA--EPSANTTLVSET 173
Query: 592 KKKGSAGA-GAHARAG-EAKGQAPTGSK 617
+++GS A GA A+ G + GQA + S+
Sbjct: 174 EEEGSVPAFGAAAKPGMVSAGQADSSSE 201
Score = 33.1 bits (74), Expect = 0.80
Identities = 114/566 (20%), Positives = 192/566 (33%), Gaps = 79/566 (13%)
Query: 112 DDGPTQAAEAGTPGEAPTPPASET-QAQDSGEVTGQAGSLLGAARNPRRGRRGRRNRTRR 170
++ ++E + E TP A QA+ SG+ + + A +PR+G
Sbjct: 336 EEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAP------- 388
Query: 171 NRLTQKGKKRSRGGRPSAPARSEAEDSSDESLGIVIEEIDQGDLSGEEDQ------SALY 224
GK + A R E SS E E Q SG+ Q A
Sbjct: 389 ---APPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKE 445
Query: 225 ATLQAAARELVRQWAPC--------------NSEGEEDGPREFLALVTVTD-KSKKEEAE 269
+ + AA R+ P +S E D RE LA + K + +
Sbjct: 446 SPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQ 505
Query: 270 KEPAGAESIRLNTKEDKNGVPDLVALLAVRDTPDEEPVDSDTSESDSQESGDQETEELDN 329
+PA + K P V + DS++S +S +S D E
Sbjct: 506 VKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVA 565
Query: 330 P---EFVAIVAYTDPSDPWAREEMLKIASVIESLGWSDEKDKRDPLRQVLSVMSKDTNGT 386
P + + + P+ A+ K V + D + S + +
Sbjct: 566 PAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSE---------SSEESSD 616
Query: 387 RVKVEEAGREVDAVVLRKAGDDGDLREC---ISTLAQPDLPP------QAKKAGRG---- 433
EEA + A + A + C +T A + P +KAG
Sbjct: 617 SADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPA 676
Query: 434 -----LFGGWSEHREDEGGLLELVALLAAQDMAEVMKEEKENAWEGGKYKYP----KGKL 484
+ GG ED E + +A + + K + +G + K KG L
Sbjct: 677 GSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAK-SVGKGLQVKAASVPVKGSL 735
Query: 485 GEVLALLAAREN---MGSNEGSEEASDEQSEEESEDTESEASEPEDRASRK-------PR 534
G+ A + + + + ++ E SEEES+ E+ AS + + S K P
Sbjct: 736 GQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPA 795
Query: 535 AKRARTAPRGLTPAGAPPTASGARKTRAGGRGRGRGVTPEKKAG-SRGSAQDDAAGSR-K 592
A RA +A ++ G TA+ K R+ + + P+ +RG A + G
Sbjct: 796 AARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVA 855
Query: 593 KKGSAGAGAHARAGEAKGQAPTGSKA 618
A G +G ++ ++ + +A
Sbjct: 856 TAAQAQTGPEEDSGSSEEESDSEEEA 881
Score = 32.7 bits (73), Expect = 1.0
Identities = 35/170 (20%), Positives = 62/170 (36%), Gaps = 24/170 (14%)
Query: 445 EGGLLELVALLAAQDMAEVM---KEEKENAWEGGKYKYPKGKLGEVLALLAARENMGSNE 501
+ +++++ L Q+ +V+ KE WE K K G+ A R
Sbjct: 1312 QASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLS----GDQPAARTPRSKKKKKL 1367
Query: 502 GSEEASDEQSEEESEDTESEASEPEDRASRKPRAKR---------ARTAPRGLTPAGAPP 552
G+ E + E T S+ D+AS + K+ A+ P G
Sbjct: 1368 GAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQKGMGT 1427
Query: 553 TASGAR--------KTRAGGRGRGRGVTPEKKAGSRGSAQDDAAGSRKKK 594
G + K ++ R + + +KK + S +D + S+KKK
Sbjct: 1428 VEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQKKK 1477
Score = 30.4 bits (67), Expect = 5.2
Identities = 33/138 (23%), Positives = 49/138 (35%), Gaps = 16/138 (11%)
Query: 502 GSEEASDEQSEEESEDTESEASEPEDRASRKPRAKRARTAPRGLTP----AGAPPTASGA 557
G EE S EE + E+E + + + S K RA AP +P A PP +G
Sbjct: 863 GPEEDSGSSEEESDSEEEAE-TLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGP 921
Query: 558 RKTRAGGRGRGRGVTPEKKAGSRGSAQDDAA-----------GSRKKKGSAGAGAHARAG 606
+AG + + E + A +A +R G A A A+A
Sbjct: 922 SAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAA 981
Query: 607 EAKGQAPTGSKAARGKKA 624
+A AR +
Sbjct: 982 STPRKARASESTARSSSS 999
>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a
[Homo sapiens]
Length = 1450
Score = 50.1 bits (118), Expect = 6e-06
Identities = 100/501 (19%), Positives = 179/501 (35%), Gaps = 61/501 (12%)
Query: 116 TQAAEAGTPGEAPTPPASETQAQDSGEVTGQAGSLLGAARNPRRGRRGRRNRTRRNRLTQ 175
++++E G+ E P + +Q + S ++ + AA P +G G+
Sbjct: 270 SESSEEGSESEEEAPAGTRSQVKASEKILQ-----VRAASAPAKGTPGKGATPAPPGKAG 324
Query: 176 KGKKRSRGGRPSAPARSEAEDSSDESLGIVIEEIDQGDLSGEEDQSALYATLQAAARELV 235
+++ G+P + S +E+SSD EE+ A A LQA A
Sbjct: 325 AVASQTKAGKPEEDSESSSEESSDS----------------EEETPAAKALLQAKASGKT 368
Query: 236 RQWAPCNSEGEEDGPREFLALVTVTDKSKKEEAEKEPAGAESIRLNTKEDKNGVPDLVAL 295
Q ++ +E PR+ A + PA A++ +ED +
Sbjct: 369 SQVGAASAPAKES-PRKGAA--------PAPPGKTGPAVAKAQAGKREEDSQSSSE---- 415
Query: 296 LAVRDTPDEEPVDSDTSESDSQESGDQETEELDNPEFVAIVAYTDPSDPWAREEMLKIAS 355
D+ +E P + S Q + ++P A A + P A + +++
Sbjct: 416 --ESDSEEEAPAQAKPSGKAPQVRAASAPAK-ESPRKGAAPAPPRKTGPAAAQ--VQVGK 470
Query: 356 VIESLGWSDEKDKRDPLRQVLSVMSKDTNGTRVKVEEAGREVDAVVLRKAGDDGDLRECI 415
E S E+ D R+ L+ M+ +V+ G+ G G L +
Sbjct: 471 QEEDSRSSSEESDSD--REALAAMNA------AQVKPLGKSPQVKPASTMGM-GPLGKGA 521
Query: 416 STLAQPDLPPQAKKAGRGLFGGWSEHREDE------GGLLELVALLAAQDMAEVMKEEKE 469
+ + P A G + SE +E G + VA + + +++ +
Sbjct: 522 GPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPT 581
Query: 470 NAWEGGKYKYPKGKLGEVLALLAARENMGSNEGSEEASDEQSEEESEDTESEASEPEDRA 529
++ G P K G V + A + M ++E SEE+SD EE+ + A A
Sbjct: 582 SSPAKG----PPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKP--A 635
Query: 530 SRKPRAKRARTAPRGLTPAGAPPTASGARKTRAGGRGRG-RGVTPEKKAGSRGSAQDDAA 588
+ P+ K A P G + R G G +P G++ A+D ++
Sbjct: 636 LKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSS 695
Query: 589 GSRKKKGSAGAGAHARAGEAK 609
G G+AK
Sbjct: 696 SEESDSEEEKTGLAVTVGQAK 716
Score = 47.4 bits (111), Expect = 4e-05
Identities = 41/151 (27%), Positives = 62/151 (41%), Gaps = 14/151 (9%)
Query: 480 PKGKLGEVLALLAARENMGSNEGSEEASDEQSEEESEDTESEASEPEDRASRKPRAKRAR 539
P GK G V A++ G E E+S E+S + E+T + + + +AS K A
Sbjct: 319 PPGKAGAV----ASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAA 374
Query: 540 TAPRGLTP-AGAPPTASGARKTRAGGRGRGRGVTPEKKAGSRGSAQDDAAGSRKKKGSA- 597
+AP +P GA P G G+ + + ++++A K G A
Sbjct: 375 SAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAP 434
Query: 598 ---GAGAHARAGEAKGQAP-----TGSKAAR 620
A A A+ KG AP TG AA+
Sbjct: 435 QVRAASAPAKESPRKGAAPAPPRKTGPAAAQ 465
Score = 45.8 bits (107), Expect = 1e-04
Identities = 41/164 (25%), Positives = 68/164 (41%), Gaps = 16/164 (9%)
Query: 482 GKLGEVLALLAARENMGSNEGSEEASDEQSEEESEDTESEA---SEPEDRASRKPRAKRA 538
GK+G+V + + + + +S EE ++E EA + + +AS K RA
Sbjct: 243 GKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRA 302
Query: 539 RTAP------RGLTPAGAPPTASGARKTRAGGRGRGRGVTPEKKAGS-------RGSAQD 585
+AP +G TPA + A +T+AG + E+ + S + Q
Sbjct: 303 ASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQA 362
Query: 586 DAAGSRKKKGSAGAGAHARAGEAKGQAPTGSKAARGKKARRGRR 629
A+G + G+A A A + AP G KA+ G+R
Sbjct: 363 KASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKR 406
Score = 45.1 bits (105), Expect = 2e-04
Identities = 111/515 (21%), Positives = 180/515 (34%), Gaps = 87/515 (16%)
Query: 123 TPGEAPTPPASETQAQDSGEVTGQAGSL--LGAARNPRRGRRGRRNRTRRNRLTQKGKKR 180
+P ++ P A+ T + T + GS+ GAA P G+ + + + + +
Sbjct: 156 SPRKSAEPSANTTLVSE----TEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETD 211
Query: 181 SRGGRPSAPARSEAED-SSDESLGIVIEEIDQ--GDLSGEEDQSALYATLQAAARELVRQ 237
G PA+ +A S+ ES GD++ + AL +A E +
Sbjct: 212 VEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESE 271
Query: 238 WAPCNSEGEEDGPREFLALVTVTDKSKKEEAEKEPAGAESIRLNTKEDKNGVPDLVALLA 297
+ SE EE+ P + V ++K + A PA + T G VA
Sbjct: 272 SSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPP-GKAGAVASQT 330
Query: 298 VRDTPDEEPVDSDTSESDSQESGDQETEELDNPEFVAIVAYTDPSDPWAREEMLKIASVI 357
P+E+ SES S+ES D E E P A++ K +
Sbjct: 331 KAGKPEED------SESSSEESSDSEEE---TPAAKALL-------------QAKASGKT 368
Query: 358 ESLGWSDEKDKRDPLRQVLSVMSKDTNGTRVKVEEAGREVDAVVLRKAGDDGDLRECIST 417
+G + K P + T K + RE D+ + + ++ D E
Sbjct: 369 SQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDS---QSSSEESDSEE---- 421
Query: 418 LAQPDLPPQAKKAGRGLFGGWSEHREDEGGLLELVALLAAQDMAEVMKEEKENAWEGGKY 477
+ P QAK +G+ A + KE+ +G
Sbjct: 422 ----EAPAQAKPSGK------------------------APQVRAASAPAKESPRKGAAP 453
Query: 478 KYPKGKLGEVLALLAARENMGSNEGSEEASDEQSEEESEDTESEASEPEDRASRKPRAKR 537
P+ K G AA+ +G E D +S E D++ EA + A KP K
Sbjct: 454 APPR-KTGPA----AAQVQVGKQE-----EDSRSSSEESDSDREALAAMNAAQVKPLGKS 503
Query: 538 ARTAPRGLTPAGAPPTASGARKTRAGGRGRGRGVTPEKKAG-----SRGSAQDDAAGSRK 592
+ P + G P GA G G TP + G S S+++ + S
Sbjct: 504 PQVKP--ASTMGMGPLGKGAGPVPPGKVG---PATPSAQVGKWEEDSESSSEESSDSSDG 558
Query: 593 KKGSAGAGAHARAGEAKGQAPTGSKAARGKKARRG 627
+ +A A A ++ QA S A+G + G
Sbjct: 559 EVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAG 593
Score = 35.8 bits (81), Expect = 0.12
Identities = 38/159 (23%), Positives = 58/159 (36%), Gaps = 18/159 (11%)
Query: 480 PKGKLGEVLALLAARENMGSNEGSEEASDEQSEEESE---DTESEASEPEDRASRKPRAK 536
P GK G +A A G E ++S E+S+ E E + P+ RA+ P
Sbjct: 390 PPGKTGPAVAKAQA----GKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAP--- 442
Query: 537 RARTAPR-GLTPAGAPPTASGARKTRAGGRGRGRGVTPEKKAGSR------GSAQDDAAG 589
A+ +PR G PA T A + + G + + E+ R +AQ G
Sbjct: 443 -AKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLG 501
Query: 590 SRKKKGSAGAGAHARAGEAKGQAPTGSKAARGKKARRGR 628
+ A G+ G P G A+ G+
Sbjct: 502 KSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGK 540
Score = 35.4 bits (80), Expect = 0.16
Identities = 37/140 (26%), Positives = 56/140 (40%), Gaps = 21/140 (15%)
Query: 510 QSEEESEDTESEASEP--EDRASRKPR-------------AKRARTAP---RGLTP---A 548
Q++ SEDT S + E E + S KP A++A AP +TP
Sbjct: 195 QADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKG 254
Query: 549 GAPPTASGARKTRAGGRGRGRGVTPEKKAGSRGSAQDDAAGSRKKKGSAGAGAHARAGEA 608
GA P A A+K G E++A + +Q A+ + +A A A G+
Sbjct: 255 GALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKG 314
Query: 609 KGQAPTGSKAARGKKARRGR 628
AP G A + + G+
Sbjct: 315 ATPAPPGKAGAVASQTKAGK 334
Score = 34.7 bits (78), Expect = 0.27
Identities = 34/116 (29%), Positives = 48/116 (41%), Gaps = 12/116 (10%)
Query: 509 EQSEEESEDTESEASEPEDRASRKPRAKRARTAPRGLTPAGAPPTASGARKTRAGGRGRG 568
EQ ++ DT E+S RK R R G PA P + +K AG G
Sbjct: 1286 EQERKKVVDTTKESS-------RKGWESRKRKLS-GDQPAARTPRSKKKKKLGAGEGGEA 1337
Query: 569 RGVTPEKKAG-SRGSAQDDAAGS--RKKKGSAGAGAHARAGEAKGQAPTGSKAARG 621
V+PEK + S+G A+ D A ++KKG G+ E + + G G
Sbjct: 1338 -SVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEG 1392
Score = 33.5 bits (75), Expect = 0.61
Identities = 45/148 (30%), Positives = 64/148 (43%), Gaps = 19/148 (12%)
Query: 481 KGKLGEVLALLAARENMGSNEGSEEASDEQSEEESE---------DTESEASEPEDRASR 531
K K E AL A + + + E+S+E+ E E+E T S + +S
Sbjct: 62 KRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSM 121
Query: 532 KPRAKRARTAPRGLTPAGAPPTASGARKTRAGGRGRGRGVTPEKKAGSRGSAQDDAAGSR 591
K +AK A T G T P A+G KT A G +P K A SA
Sbjct: 122 KEKAK-AETEKAGKTGNSMPHPATG--KTVANLLS---GKSPRKSA--EPSANTTLVSET 173
Query: 592 KKKGSAGA-GAHARAG-EAKGQAPTGSK 617
+++GS A GA A+ G + GQA + S+
Sbjct: 174 EEEGSVPAFGAAAKPGMVSAGQADSSSE 201
Score = 33.1 bits (74), Expect = 0.80
Identities = 114/566 (20%), Positives = 192/566 (33%), Gaps = 79/566 (13%)
Query: 112 DDGPTQAAEAGTPGEAPTPPASET-QAQDSGEVTGQAGSLLGAARNPRRGRRGRRNRTRR 170
++ ++E + E TP A QA+ SG+ + + A +PR+G
Sbjct: 336 EEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAP------- 388
Query: 171 NRLTQKGKKRSRGGRPSAPARSEAEDSSDESLGIVIEEIDQGDLSGEEDQ------SALY 224
GK + A R E SS E E Q SG+ Q A
Sbjct: 389 ---APPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKE 445
Query: 225 ATLQAAARELVRQWAPC--------------NSEGEEDGPREFLALVTVTD-KSKKEEAE 269
+ + AA R+ P +S E D RE LA + K + +
Sbjct: 446 SPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQ 505
Query: 270 KEPAGAESIRLNTKEDKNGVPDLVALLAVRDTPDEEPVDSDTSESDSQESGDQETEELDN 329
+PA + K P V + DS++S +S +S D E
Sbjct: 506 VKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVA 565
Query: 330 P---EFVAIVAYTDPSDPWAREEMLKIASVIESLGWSDEKDKRDPLRQVLSVMSKDTNGT 386
P + + + P+ A+ K V + D + S + +
Sbjct: 566 PAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSE---------SSEESSD 616
Query: 387 RVKVEEAGREVDAVVLRKAGDDGDLREC---ISTLAQPDLPP------QAKKAGRG---- 433
EEA + A + A + C +T A + P +KAG
Sbjct: 617 SADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPA 676
Query: 434 -----LFGGWSEHREDEGGLLELVALLAAQDMAEVMKEEKENAWEGGKYKYP----KGKL 484
+ GG ED E + +A + + K + +G + K KG L
Sbjct: 677 GSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAK-SVGKGLQVKAASVPVKGSL 735
Query: 485 GEVLALLAAREN---MGSNEGSEEASDEQSEEESEDTESEASEPEDRASRK-------PR 534
G+ A + + + + ++ E SEEES+ E+ AS + + S K P
Sbjct: 736 GQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPA 795
Query: 535 AKRARTAPRGLTPAGAPPTASGARKTRAGGRGRGRGVTPEKKAG-SRGSAQDDAAGSR-K 592
A RA +A ++ G TA+ K R+ + + P+ +RG A + G
Sbjct: 796 AARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVA 855
Query: 593 KKGSAGAGAHARAGEAKGQAPTGSKA 618
A G +G ++ ++ + +A
Sbjct: 856 TAAQAQTGPEEDSGSSEEESDSEEEA 881
Score = 32.7 bits (73), Expect = 1.0
Identities = 35/170 (20%), Positives = 62/170 (36%), Gaps = 24/170 (14%)
Query: 445 EGGLLELVALLAAQDMAEVM---KEEKENAWEGGKYKYPKGKLGEVLALLAARENMGSNE 501
+ +++++ L Q+ +V+ KE WE K K G+ A R
Sbjct: 1274 QASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLS----GDQPAARTPRSKKKKKL 1329
Query: 502 GSEEASDEQSEEESEDTESEASEPEDRASRKPRAKR---------ARTAPRGLTPAGAPP 552
G+ E + E T S+ D+AS + K+ A+ P G
Sbjct: 1330 GAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQKGMGT 1389
Query: 553 TASGAR--------KTRAGGRGRGRGVTPEKKAGSRGSAQDDAAGSRKKK 594
G + K ++ R + + +KK + S +D + S+KKK
Sbjct: 1390 VEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQKKK 1439
Score = 30.4 bits (67), Expect = 5.2
Identities = 33/138 (23%), Positives = 49/138 (35%), Gaps = 16/138 (11%)
Query: 502 GSEEASDEQSEEESEDTESEASEPEDRASRKPRAKRARTAPRGLTP----AGAPPTASGA 557
G EE S EE + E+E + + + S K RA AP +P A PP +G
Sbjct: 863 GPEEDSGSSEEESDSEEEAE-TLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGP 921
Query: 558 RKTRAGGRGRGRGVTPEKKAGSRGSAQDDAA-----------GSRKKKGSAGAGAHARAG 606
+AG + + E + A +A +R G A A A+A
Sbjct: 922 SAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAA 981
Query: 607 EAKGQAPTGSKAARGKKA 624
+A AR +
Sbjct: 982 STPRKARASESTARSSSS 999
>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c
[Homo sapiens]
Length = 958
Score = 50.1 bits (118), Expect = 6e-06
Identities = 100/501 (19%), Positives = 179/501 (35%), Gaps = 61/501 (12%)
Query: 116 TQAAEAGTPGEAPTPPASETQAQDSGEVTGQAGSLLGAARNPRRGRRGRRNRTRRNRLTQ 175
++++E G+ E P + +Q + S ++ + AA P +G G+
Sbjct: 270 SESSEEGSESEEEAPAGTRSQVKASEKILQ-----VRAASAPAKGTPGKGATPAPPGKAG 324
Query: 176 KGKKRSRGGRPSAPARSEAEDSSDESLGIVIEEIDQGDLSGEEDQSALYATLQAAARELV 235
+++ G+P + S +E+SSD EE+ A A LQA A
Sbjct: 325 AVASQTKAGKPEEDSESSSEESSDS----------------EEETPAAKALLQAKASGKT 368
Query: 236 RQWAPCNSEGEEDGPREFLALVTVTDKSKKEEAEKEPAGAESIRLNTKEDKNGVPDLVAL 295
Q ++ +E PR+ A + PA A++ +ED +
Sbjct: 369 SQVGAASAPAKES-PRKGAA--------PAPPGKTGPAVAKAQAGKREEDSQSSSE---- 415
Query: 296 LAVRDTPDEEPVDSDTSESDSQESGDQETEELDNPEFVAIVAYTDPSDPWAREEMLKIAS 355
D+ +E P + S Q + ++P A A + P A + +++
Sbjct: 416 --ESDSEEEAPAQAKPSGKAPQVRAASAPAK-ESPRKGAAPAPPRKTGPAAAQ--VQVGK 470
Query: 356 VIESLGWSDEKDKRDPLRQVLSVMSKDTNGTRVKVEEAGREVDAVVLRKAGDDGDLRECI 415
E S E+ D R+ L+ M+ +V+ G+ G G L +
Sbjct: 471 QEEDSRSSSEESDSD--REALAAMNA------AQVKPLGKSPQVKPASTMGM-GPLGKGA 521
Query: 416 STLAQPDLPPQAKKAGRGLFGGWSEHREDE------GGLLELVALLAAQDMAEVMKEEKE 469
+ + P A G + SE +E G + VA + + +++ +
Sbjct: 522 GPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPT 581
Query: 470 NAWEGGKYKYPKGKLGEVLALLAARENMGSNEGSEEASDEQSEEESEDTESEASEPEDRA 529
++ G P K G V + A + M ++E SEE+SD EE+ + A A
Sbjct: 582 SSPAKG----PPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKP--A 635
Query: 530 SRKPRAKRARTAPRGLTPAGAPPTASGARKTRAGGRGRG-RGVTPEKKAGSRGSAQDDAA 588
+ P+ K A P G + R G G +P G++ A+D ++
Sbjct: 636 LKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSS 695
Query: 589 GSRKKKGSAGAGAHARAGEAK 609
G G+AK
Sbjct: 696 SEESDSEEEKTGLAVTVGQAK 716
Score = 47.4 bits (111), Expect = 4e-05
Identities = 41/151 (27%), Positives = 62/151 (41%), Gaps = 14/151 (9%)
Query: 480 PKGKLGEVLALLAARENMGSNEGSEEASDEQSEEESEDTESEASEPEDRASRKPRAKRAR 539
P GK G V A++ G E E+S E+S + E+T + + + +AS K A
Sbjct: 319 PPGKAGAV----ASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAA 374
Query: 540 TAPRGLTP-AGAPPTASGARKTRAGGRGRGRGVTPEKKAGSRGSAQDDAAGSRKKKGSA- 597
+AP +P GA P G G+ + + ++++A K G A
Sbjct: 375 SAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAP 434
Query: 598 ---GAGAHARAGEAKGQAP-----TGSKAAR 620
A A A+ KG AP TG AA+
Sbjct: 435 QVRAASAPAKESPRKGAAPAPPRKTGPAAAQ 465
Score = 45.8 bits (107), Expect = 1e-04
Identities = 41/164 (25%), Positives = 68/164 (41%), Gaps = 16/164 (9%)
Query: 482 GKLGEVLALLAARENMGSNEGSEEASDEQSEEESEDTESEA---SEPEDRASRKPRAKRA 538
GK+G+V + + + + +S EE ++E EA + + +AS K RA
Sbjct: 243 GKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRA 302
Query: 539 RTAP------RGLTPAGAPPTASGARKTRAGGRGRGRGVTPEKKAGS-------RGSAQD 585
+AP +G TPA + A +T+AG + E+ + S + Q
Sbjct: 303 ASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQA 362
Query: 586 DAAGSRKKKGSAGAGAHARAGEAKGQAPTGSKAARGKKARRGRR 629
A+G + G+A A A + AP G KA+ G+R
Sbjct: 363 KASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKR 406
Score = 45.1 bits (105), Expect = 2e-04
Identities = 111/515 (21%), Positives = 180/515 (34%), Gaps = 87/515 (16%)
Query: 123 TPGEAPTPPASETQAQDSGEVTGQAGSL--LGAARNPRRGRRGRRNRTRRNRLTQKGKKR 180
+P ++ P A+ T + T + GS+ GAA P G+ + + + + +
Sbjct: 156 SPRKSAEPSANTTLVSE----TEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETD 211
Query: 181 SRGGRPSAPARSEAED-SSDESLGIVIEEIDQ--GDLSGEEDQSALYATLQAAARELVRQ 237
G PA+ +A S+ ES GD++ + AL +A E +
Sbjct: 212 VEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESE 271
Query: 238 WAPCNSEGEEDGPREFLALVTVTDKSKKEEAEKEPAGAESIRLNTKEDKNGVPDLVALLA 297
+ SE EE+ P + V ++K + A PA + T G VA
Sbjct: 272 SSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPP-GKAGAVASQT 330
Query: 298 VRDTPDEEPVDSDTSESDSQESGDQETEELDNPEFVAIVAYTDPSDPWAREEMLKIASVI 357
P+E+ SES S+ES D E E P A++ K +
Sbjct: 331 KAGKPEED------SESSSEESSDSEEE---TPAAKALL-------------QAKASGKT 368
Query: 358 ESLGWSDEKDKRDPLRQVLSVMSKDTNGTRVKVEEAGREVDAVVLRKAGDDGDLRECIST 417
+G + K P + T K + RE D+ + + ++ D E
Sbjct: 369 SQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDS---QSSSEESDSEE---- 421
Query: 418 LAQPDLPPQAKKAGRGLFGGWSEHREDEGGLLELVALLAAQDMAEVMKEEKENAWEGGKY 477
+ P QAK +G+ A + KE+ +G
Sbjct: 422 ----EAPAQAKPSGK------------------------APQVRAASAPAKESPRKGAAP 453
Query: 478 KYPKGKLGEVLALLAARENMGSNEGSEEASDEQSEEESEDTESEASEPEDRASRKPRAKR 537
P+ K G AA+ +G E D +S E D++ EA + A KP K
Sbjct: 454 APPR-KTGPA----AAQVQVGKQE-----EDSRSSSEESDSDREALAAMNAAQVKPLGKS 503
Query: 538 ARTAPRGLTPAGAPPTASGARKTRAGGRGRGRGVTPEKKAG-----SRGSAQDDAAGSRK 592
+ P + G P GA G G TP + G S S+++ + S
Sbjct: 504 PQVKP--ASTMGMGPLGKGAGPVPPGKVG---PATPSAQVGKWEEDSESSSEESSDSSDG 558
Query: 593 KKGSAGAGAHARAGEAKGQAPTGSKAARGKKARRG 627
+ +A A A ++ QA S A+G + G
Sbjct: 559 EVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAG 593
Score = 35.8 bits (81), Expect = 0.12
Identities = 38/159 (23%), Positives = 58/159 (36%), Gaps = 18/159 (11%)
Query: 480 PKGKLGEVLALLAARENMGSNEGSEEASDEQSEEESE---DTESEASEPEDRASRKPRAK 536
P GK G +A A G E ++S E+S+ E E + P+ RA+ P
Sbjct: 390 PPGKTGPAVAKAQA----GKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAP--- 442
Query: 537 RARTAPR-GLTPAGAPPTASGARKTRAGGRGRGRGVTPEKKAGSR------GSAQDDAAG 589
A+ +PR G PA T A + + G + + E+ R +AQ G
Sbjct: 443 -AKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLG 501
Query: 590 SRKKKGSAGAGAHARAGEAKGQAPTGSKAARGKKARRGR 628
+ A G+ G P G A+ G+
Sbjct: 502 KSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGK 540
Score = 35.4 bits (80), Expect = 0.16
Identities = 37/140 (26%), Positives = 56/140 (40%), Gaps = 21/140 (15%)
Query: 510 QSEEESEDTESEASEP--EDRASRKPR-------------AKRARTAP---RGLTP---A 548
Q++ SEDT S + E E + S KP A++A AP +TP
Sbjct: 195 QADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKG 254
Query: 549 GAPPTASGARKTRAGGRGRGRGVTPEKKAGSRGSAQDDAAGSRKKKGSAGAGAHARAGEA 608
GA P A A+K G E++A + +Q A+ + +A A A G+
Sbjct: 255 GALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKG 314
Query: 609 KGQAPTGSKAARGKKARRGR 628
AP G A + + G+
Sbjct: 315 ATPAPPGKAGAVASQTKAGK 334
Score = 33.5 bits (75), Expect = 0.61
Identities = 45/148 (30%), Positives = 64/148 (43%), Gaps = 19/148 (12%)
Query: 481 KGKLGEVLALLAARENMGSNEGSEEASDEQSEEESE---------DTESEASEPEDRASR 531
K K E AL A + + + E+S+E+ E E+E T S + +S
Sbjct: 62 KRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSM 121
Query: 532 KPRAKRARTAPRGLTPAGAPPTASGARKTRAGGRGRGRGVTPEKKAGSRGSAQDDAAGSR 591
K +AK A T G T P A+G KT A G +P K A SA
Sbjct: 122 KEKAK-AETEKAGKTGNSMPHPATG--KTVANLLS---GKSPRKSA--EPSANTTLVSET 173
Query: 592 KKKGSAGA-GAHARAG-EAKGQAPTGSK 617
+++GS A GA A+ G + GQA + S+
Sbjct: 174 EEEGSVPAFGAAAKPGMVSAGQADSSSE 201
Score = 33.1 bits (74), Expect = 0.80
Identities = 114/566 (20%), Positives = 192/566 (33%), Gaps = 79/566 (13%)
Query: 112 DDGPTQAAEAGTPGEAPTPPASET-QAQDSGEVTGQAGSLLGAARNPRRGRRGRRNRTRR 170
++ ++E + E TP A QA+ SG+ + + A +PR+G
Sbjct: 336 EEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAP------- 388
Query: 171 NRLTQKGKKRSRGGRPSAPARSEAEDSSDESLGIVIEEIDQGDLSGEEDQ------SALY 224
GK + A R E SS E E Q SG+ Q A
Sbjct: 389 ---APPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKE 445
Query: 225 ATLQAAARELVRQWAPC--------------NSEGEEDGPREFLALVTVTD-KSKKEEAE 269
+ + AA R+ P +S E D RE LA + K + +
Sbjct: 446 SPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQ 505
Query: 270 KEPAGAESIRLNTKEDKNGVPDLVALLAVRDTPDEEPVDSDTSESDSQESGDQETEELDN 329
+PA + K P V + DS++S +S +S D E
Sbjct: 506 VKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVA 565
Query: 330 P---EFVAIVAYTDPSDPWAREEMLKIASVIESLGWSDEKDKRDPLRQVLSVMSKDTNGT 386
P + + + P+ A+ K V + D + S + +
Sbjct: 566 PAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSE---------SSEESSD 616
Query: 387 RVKVEEAGREVDAVVLRKAGDDGDLREC---ISTLAQPDLPP------QAKKAGRG---- 433
EEA + A + A + C +T A + P +KAG
Sbjct: 617 SADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPA 676
Query: 434 -----LFGGWSEHREDEGGLLELVALLAAQDMAEVMKEEKENAWEGGKYKYP----KGKL 484
+ GG ED E + +A + + K + +G + K KG L
Sbjct: 677 GSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAK-SVGKGLQVKAASVPVKGSL 735
Query: 485 GEVLALLAAREN---MGSNEGSEEASDEQSEEESEDTESEASEPEDRASRK-------PR 534
G+ A + + + + ++ E SEEES+ E+ AS + + S K P
Sbjct: 736 GQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPA 795
Query: 535 AKRARTAPRGLTPAGAPPTASGARKTRAGGRGRGRGVTPEKKAG-SRGSAQDDAAGSR-K 592
A RA +A ++ G TA+ K R+ + + P+ +RG A + G
Sbjct: 796 AARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVA 855
Query: 593 KKGSAGAGAHARAGEAKGQAPTGSKA 618
A G +G ++ ++ + +A
Sbjct: 856 TAAQAQTGPEEDSGSSEEESDSEEEA 881
Score = 30.8 bits (68), Expect = 4.0
Identities = 30/98 (30%), Positives = 39/98 (39%), Gaps = 18/98 (18%)
Query: 502 GSEEASDEQSEEESEDTESEASEPEDRASRKPRAKRARTAPRGLTP-AGAPPTASGARKT 560
G EE S SEEES+ E + + + S K RA AP +P GA PT G
Sbjct: 863 GPEEDSGS-SEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGP 921
Query: 561 RAGGRGRGRGVTPEKKAGSRGSAQDDAAGSRKKKGSAG 598
A G+ QDD+ S ++ S G
Sbjct: 922 SAAQAGK----------------QDDSGSSSEESDSDG 943
>gi|21396500 HIRA interacting protein 3 [Homo sapiens]
Length = 556
Score = 48.9 bits (115), Expect = 1e-05
Identities = 86/352 (24%), Positives = 135/352 (38%), Gaps = 39/352 (11%)
Query: 301 TPDEEPVDSDTSESDSQESGDQET--EELDNPEFVAIVAYTDPSDPWAREEMLKIAS--V 356
TP +P + ESG + + + P + A P A+EE + AS V
Sbjct: 84 TPCSDPERKRFRFNSESESGSEASSPDYFGPPAKNGVAAEVSP----AKEENPRRASKAV 139
Query: 357 IESLGWSDEKDKRD-PLRQVLSVMSKDTNGTRVK------VEEAGREVDAVVLRKAGDDG 409
ES SDE+ +RD P ++ ++ G + K V++ +V ++A ++
Sbjct: 140 EES---SDEERQRDLPAQRGEESSEEEEKGYKGKTRKKPVVKKQAPGKASVSRKQAREES 196
Query: 410 DLRECISTLAQPDLPPQAKKAGRGLFGGWSEHREDEGGLLELVALLAAQDMAEVMKEEKE 469
+ E A+P + AKK G G S ++ E++A Q EV +EEKE
Sbjct: 197 EESE-----AEP-VQRTAKKV-EGNKGTKSLKESEQESEEEILAQKKEQREEEVEEEEKE 249
Query: 470 NAWEGGKYKYPKGKLGEVLALLAARENMGSNEGSEEASDEQSEEESEDTESEASEP---- 525
E G +K G + R ++ D SEEE ++ S +
Sbjct: 250 EDEEKGDWKPRTRSNGRRKSAREERSCKQKSQAKRLLGDSDSEEEQKEAASSGDDSGRDR 309
Query: 526 --------EDRASRKPRAKRARTAPRGLTPAGAPPTASGARKTRAGGRGRGRGVTPEKKA 577
EDR K + + ++ PTA G+RK G G E++
Sbjct: 310 EPPVQRKSEDRTQLKGGKRLSGSSEDEEDSGKGEPTAKGSRKMARLGSTSGEESDLEREV 369
Query: 578 GSRGSAQDDAAGSRKKKGSAGAGAHARAGEAKGQAPTGSKAARGKKARRGRR 629
S A G RK + S + R + + GS A+G KA GRR
Sbjct: 370 -SDSEAGGGPQGERKNRSSKKSSRKGRT-RSSSSSSDGSPEAKGGKAGSGRR 419
Score = 35.0 bits (79), Expect = 0.21
Identities = 57/268 (21%), Positives = 103/268 (38%), Gaps = 55/268 (20%)
Query: 365 EKDKRDPLRQVLSVM--SKDTNGTRVKVEEAGREVDAVVLRKAGDDGDLRECISTLAQPD 422
E+ + +P+++ + +K T + +E+ E+ A + ++ + E + D
Sbjct: 197 EESEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQKKEQREEEVEEEEKEEDEEKGD 256
Query: 423 LPPQAKKAGRGLFGGWSEHREDEGGLLELVA--LLAAQDMAEVMKEEKENAWEGGKYKYP 480
P+ + GR RE+ + A LL D E KE + + G+ + P
Sbjct: 257 WKPRTRSNGRR-----KSAREERSCKQKSQAKRLLGDSDSEEEQKEAASSGDDSGRDREP 311
Query: 481 --KGKLGEVLALLAARENMGSNEGSEEA-------------------SDEQSEEESEDTE 519
+ K + L + GS+E E++ S E+S+ E E ++
Sbjct: 312 PVQRKSEDRTQLKGGKRLSGSSEDEEDSGKGEPTAKGSRKMARLGSTSGEESDLEREVSD 371
Query: 520 SEA-----SEPEDRASRKPRAKRARTAPRGLTPAGAPPTASGARKTRAGGRGRGRGVTPE 574
SEA E ++R+S+K +++ RT + G+P G
Sbjct: 372 SEAGGGPQGERKNRSSKK-SSRKGRTRSSSSSSDGSPEAKGG------------------ 412
Query: 575 KKAGSRGSAQDDAAGSRKKKGSAGAGAH 602
KAGS +D A R K+ GAH
Sbjct: 413 -KAGSGRRGEDHPAVMRLKRYIRACGAH 439
>gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f
[Homo sapiens]
Length = 1412
Score = 47.4 bits (111), Expect = 4e-05
Identities = 101/536 (18%), Positives = 174/536 (32%), Gaps = 74/536 (13%)
Query: 126 EAPTPPASETQAQDSGEVTGQAGSLLGAARNPRRGRRGRRNRTRRNRLTQKGKKRSRGG- 184
+A T A +T TG+ + L + ++PR+ N T + ++G + G
Sbjct: 126 KAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAA 185
Query: 185 -RPSAPARSEAEDSSDESLGIVIEEIDQGDLSGEEDQSALYATLQAAARELVRQWAPCNS 243
+P + +A+ SS+++ D+ D+ + + L Q A + P
Sbjct: 186 AKPGMVSAGQADSSSEDTSS----SSDETDVEVKASEKIL----QVRAASAPAKGTP--G 235
Query: 244 EGEEDGPREFLALVTVTDKSKKEEAEKEPAGAESIRLNTKEDKNGVPDLVALLAVR---- 299
+G P V K+ K E + E + ES + + P ALL +
Sbjct: 236 KGATPAPPGKAGAVASQTKAGKPEEDSESSSEES-----SDSEEETPAAKALLQAKASGK 290
Query: 300 -------DTPDEE---------------PVDSDTSESDSQESGDQETEELDNPEFVAIVA 337
P +E P + +E +EE D+ E A
Sbjct: 291 TSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQA 350
Query: 338 YTDPSDPWAREEMLKIASVIESLGWSDEKDKRDPLRQVLSVMSKDTNGTRVKVEEAGREV 397
P R K P + V K +R EE+ +
Sbjct: 351 KPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQV-GKQEEDSRSSSEESDSDR 409
Query: 398 DAVVLRKAGDDGDLREC--ISTLAQPDLPPQAKKAG------------RGLFGGWSEHRE 443
+A+ A L + + + + P K AG G W E E
Sbjct: 410 EALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSE 469
Query: 444 D---------EGGLLELVALLAAQDMAEVMKEEKENAWEGGKYKYPKGKLGEVLALLAAR 494
+G + VA + + +++ + ++ G P K G V + A
Sbjct: 470 SSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKG----PPQKAGPVAVQVKAE 525
Query: 495 ENMGSNEGSEEASDEQSEEESEDTESEASEPEDRASRKPRAKRARTAPRGLTPAGAPPTA 554
+ M ++E SEE+SD EE+ + A A + P+ K A P
Sbjct: 526 KPMDNSESSEESSDSADSEEAPAAMTAAQAKP--ALKIPQTKACPKKTNTTASAKVAPVR 583
Query: 555 SGARKTRAGGRGRG-RGVTPEKKAGSRGSAQDDAAGSRKKKGSAGAGAHARAGEAK 609
G + R G G +P G++ A+D ++ G G+AK
Sbjct: 584 VGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAK 639
Score = 47.4 bits (111), Expect = 4e-05
Identities = 41/151 (27%), Positives = 62/151 (41%), Gaps = 14/151 (9%)
Query: 480 PKGKLGEVLALLAARENMGSNEGSEEASDEQSEEESEDTESEASEPEDRASRKPRAKRAR 539
P GK G V A++ G E E+S E+S + E+T + + + +AS K A
Sbjct: 242 PPGKAGAV----ASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAA 297
Query: 540 TAPRGLTP-AGAPPTASGARKTRAGGRGRGRGVTPEKKAGSRGSAQDDAAGSRKKKGSA- 597
+AP +P GA P G G+ + + ++++A K G A
Sbjct: 298 SAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAP 357
Query: 598 ---GAGAHARAGEAKGQAP-----TGSKAAR 620
A A A+ KG AP TG AA+
Sbjct: 358 QVRAASAPAKESPRKGAAPAPPRKTGPAAAQ 388
Score = 44.3 bits (103), Expect = 3e-04
Identities = 38/135 (28%), Positives = 57/135 (42%), Gaps = 15/135 (11%)
Query: 510 QSEEESEDTESEASEP--EDRASRKPRAKRARTAP------RGLTPAGAPPTASGARKTR 561
Q++ SEDT S + E E +AS K RA +AP +G TPA + A +T+
Sbjct: 195 QADSSSEDTSSSSDETDVEVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTK 254
Query: 562 AG-------GRGRGRGVTPEKKAGSRGSAQDDAAGSRKKKGSAGAGAHARAGEAKGQAPT 614
AG + E+ ++ Q A+G + G+A A A + AP
Sbjct: 255 AGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPP 314
Query: 615 GSKAARGKKARRGRR 629
G KA+ G+R
Sbjct: 315 GKTGPAVAKAQAGKR 329
Score = 35.8 bits (81), Expect = 0.12
Identities = 38/159 (23%), Positives = 58/159 (36%), Gaps = 18/159 (11%)
Query: 480 PKGKLGEVLALLAARENMGSNEGSEEASDEQSEEESE---DTESEASEPEDRASRKPRAK 536
P GK G +A A G E ++S E+S+ E E + P+ RA+ P
Sbjct: 313 PPGKTGPAVAKAQA----GKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAP--- 365
Query: 537 RARTAPR-GLTPAGAPPTASGARKTRAGGRGRGRGVTPEKKAGSR------GSAQDDAAG 589
A+ +PR G PA T A + + G + + E+ R +AQ G
Sbjct: 366 -AKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLG 424
Query: 590 SRKKKGSAGAGAHARAGEAKGQAPTGSKAARGKKARRGR 628
+ A G+ G P G A+ G+
Sbjct: 425 KSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGK 463
Score = 34.7 bits (78), Expect = 0.27
Identities = 34/116 (29%), Positives = 48/116 (41%), Gaps = 12/116 (10%)
Query: 509 EQSEEESEDTESEASEPEDRASRKPRAKRARTAPRGLTPAGAPPTASGARKTRAGGRGRG 568
EQ ++ DT E+S RK R R G PA P + +K AG G
Sbjct: 1248 EQERKKVVDTTKESS-------RKGWESRKRKLS-GDQPAARTPRSKKKKKLGAGEGGEA 1299
Query: 569 RGVTPEKKAG-SRGSAQDDAAGS--RKKKGSAGAGAHARAGEAKGQAPTGSKAARG 621
V+PEK + S+G A+ D A ++KKG G+ E + + G G
Sbjct: 1300 -SVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEG 1354
Score = 33.5 bits (75), Expect = 0.61
Identities = 45/148 (30%), Positives = 64/148 (43%), Gaps = 19/148 (12%)
Query: 481 KGKLGEVLALLAARENMGSNEGSEEASDEQSEEESE---------DTESEASEPEDRASR 531
K K E AL A + + + E+S+E+ E E+E T S + +S
Sbjct: 62 KRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSM 121
Query: 532 KPRAKRARTAPRGLTPAGAPPTASGARKTRAGGRGRGRGVTPEKKAGSRGSAQDDAAGSR 591
K +AK A T G T P A+G KT A G +P K A SA
Sbjct: 122 KEKAK-AETEKAGKTGNSMPHPATG--KTVANLLS---GKSPRKSA--EPSANTTLVSET 173
Query: 592 KKKGSAGA-GAHARAG-EAKGQAPTGSK 617
+++GS A GA A+ G + GQA + S+
Sbjct: 174 EEEGSVPAFGAAAKPGMVSAGQADSSSE 201
Score = 33.1 bits (74), Expect = 0.80
Identities = 114/566 (20%), Positives = 192/566 (33%), Gaps = 79/566 (13%)
Query: 112 DDGPTQAAEAGTPGEAPTPPASET-QAQDSGEVTGQAGSLLGAARNPRRGRRGRRNRTRR 170
++ ++E + E TP A QA+ SG+ + + A +PR+G
Sbjct: 259 EEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAP------- 311
Query: 171 NRLTQKGKKRSRGGRPSAPARSEAEDSSDESLGIVIEEIDQGDLSGEEDQ------SALY 224
GK + A R E SS E E Q SG+ Q A
Sbjct: 312 ---APPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKE 368
Query: 225 ATLQAAARELVRQWAPC--------------NSEGEEDGPREFLALVTVTD-KSKKEEAE 269
+ + AA R+ P +S E D RE LA + K + +
Sbjct: 369 SPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQ 428
Query: 270 KEPAGAESIRLNTKEDKNGVPDLVALLAVRDTPDEEPVDSDTSESDSQESGDQETEELDN 329
+PA + K P V + DS++S +S +S D E
Sbjct: 429 VKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVA 488
Query: 330 P---EFVAIVAYTDPSDPWAREEMLKIASVIESLGWSDEKDKRDPLRQVLSVMSKDTNGT 386
P + + + P+ A+ K V + D + S + +
Sbjct: 489 PAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSE---------SSEESSD 539
Query: 387 RVKVEEAGREVDAVVLRKAGDDGDLREC---ISTLAQPDLPP------QAKKAGRG---- 433
EEA + A + A + C +T A + P +KAG
Sbjct: 540 SADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPA 599
Query: 434 -----LFGGWSEHREDEGGLLELVALLAAQDMAEVMKEEKENAWEGGKYKYP----KGKL 484
+ GG ED E + +A + + K + +G + K KG L
Sbjct: 600 GSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAK-SVGKGLQVKAASVPVKGSL 658
Query: 485 GEVLALLAAREN---MGSNEGSEEASDEQSEEESEDTESEASEPEDRASRK-------PR 534
G+ A + + + + ++ E SEEES+ E+ AS + + S K P
Sbjct: 659 GQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPA 718
Query: 535 AKRARTAPRGLTPAGAPPTASGARKTRAGGRGRGRGVTPEKKAG-SRGSAQDDAAGSR-K 592
A RA +A ++ G TA+ K R+ + + P+ +RG A + G
Sbjct: 719 AARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVA 778
Query: 593 KKGSAGAGAHARAGEAKGQAPTGSKA 618
A G +G ++ ++ + +A
Sbjct: 779 TAAQAQTGPEEDSGSSEEESDSEEEA 804
Score = 32.7 bits (73), Expect = 1.0
Identities = 35/170 (20%), Positives = 62/170 (36%), Gaps = 24/170 (14%)
Query: 445 EGGLLELVALLAAQDMAEVM---KEEKENAWEGGKYKYPKGKLGEVLALLAARENMGSNE 501
+ +++++ L Q+ +V+ KE WE K K G+ A R
Sbjct: 1236 QASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLS----GDQPAARTPRSKKKKKL 1291
Query: 502 GSEEASDEQSEEESEDTESEASEPEDRASRKPRAKR---------ARTAPRGLTPAGAPP 552
G+ E + E T S+ D+AS + K+ A+ P G
Sbjct: 1292 GAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQKGMGT 1351
Query: 553 TASGAR--------KTRAGGRGRGRGVTPEKKAGSRGSAQDDAAGSRKKK 594
G + K ++ R + + +KK + S +D + S+KKK
Sbjct: 1352 VEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQKKK 1401
Score = 30.4 bits (67), Expect = 5.2
Identities = 33/138 (23%), Positives = 49/138 (35%), Gaps = 16/138 (11%)
Query: 502 GSEEASDEQSEEESEDTESEASEPEDRASRKPRAKRARTAPRGLTP----AGAPPTASGA 557
G EE S EE + E+E + + + S K RA AP +P A PP +G
Sbjct: 786 GPEEDSGSSEEESDSEEEAE-TLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGP 844
Query: 558 RKTRAGGRGRGRGVTPEKKAGSRGSAQDDAA-----------GSRKKKGSAGAGAHARAG 606
+AG + + E + A +A +R G A A A+A
Sbjct: 845 SAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAA 904
Query: 607 EAKGQAPTGSKAARGKKA 624
+A AR +
Sbjct: 905 STPRKARASESTARSSSS 922
>gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b
[Homo sapiens]
Length = 1411
Score = 47.4 bits (111), Expect = 4e-05
Identities = 101/536 (18%), Positives = 174/536 (32%), Gaps = 74/536 (13%)
Query: 126 EAPTPPASETQAQDSGEVTGQAGSLLGAARNPRRGRRGRRNRTRRNRLTQKGKKRSRGG- 184
+A T A +T TG+ + L + ++PR+ N T + ++G + G
Sbjct: 126 KAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAA 185
Query: 185 -RPSAPARSEAEDSSDESLGIVIEEIDQGDLSGEEDQSALYATLQAAARELVRQWAPCNS 243
+P + +A+ SS+++ D+ D+ + + L Q A + P
Sbjct: 186 AKPGMVSAGQADSSSEDTSS----SSDETDVEVKASEKIL----QVRAASAPAKGTP--G 235
Query: 244 EGEEDGPREFLALVTVTDKSKKEEAEKEPAGAESIRLNTKEDKNGVPDLVALLAVR---- 299
+G P V K+ K E + E + ES + + P ALL +
Sbjct: 236 KGATPAPPGKAGAVASQTKAGKPEEDSESSSEES-----SDSEEETPAAKALLQAKASGK 290
Query: 300 -------DTPDEE---------------PVDSDTSESDSQESGDQETEELDNPEFVAIVA 337
P +E P + +E +EE D+ E A
Sbjct: 291 TSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQA 350
Query: 338 YTDPSDPWAREEMLKIASVIESLGWSDEKDKRDPLRQVLSVMSKDTNGTRVKVEEAGREV 397
P R K P + V K +R EE+ +
Sbjct: 351 KPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQV-GKQEEDSRSSSEESDSDR 409
Query: 398 DAVVLRKAGDDGDLREC--ISTLAQPDLPPQAKKAG------------RGLFGGWSEHRE 443
+A+ A L + + + + P K AG G W E E
Sbjct: 410 EALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSE 469
Query: 444 D---------EGGLLELVALLAAQDMAEVMKEEKENAWEGGKYKYPKGKLGEVLALLAAR 494
+G + VA + + +++ + ++ G P K G V + A
Sbjct: 470 SSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKG----PPQKAGPVAVQVKAE 525
Query: 495 ENMGSNEGSEEASDEQSEEESEDTESEASEPEDRASRKPRAKRARTAPRGLTPAGAPPTA 554
+ M ++E SEE+SD EE+ + A A + P+ K A P
Sbjct: 526 KPMDNSESSEESSDSADSEEAPAAMTAAQAKP--ALKIPQTKACPKKTNTTASAKVAPVR 583
Query: 555 SGARKTRAGGRGRG-RGVTPEKKAGSRGSAQDDAAGSRKKKGSAGAGAHARAGEAK 609
G + R G G +P G++ A+D ++ G G+AK
Sbjct: 584 VGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAK 639
Score = 47.4 bits (111), Expect = 4e-05
Identities = 41/151 (27%), Positives = 62/151 (41%), Gaps = 14/151 (9%)
Query: 480 PKGKLGEVLALLAARENMGSNEGSEEASDEQSEEESEDTESEASEPEDRASRKPRAKRAR 539
P GK G V A++ G E E+S E+S + E+T + + + +AS K A
Sbjct: 242 PPGKAGAV----ASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAA 297
Query: 540 TAPRGLTP-AGAPPTASGARKTRAGGRGRGRGVTPEKKAGSRGSAQDDAAGSRKKKGSA- 597
+AP +P GA P G G+ + + ++++A K G A
Sbjct: 298 SAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAP 357
Query: 598 ---GAGAHARAGEAKGQAP-----TGSKAAR 620
A A A+ KG AP TG AA+
Sbjct: 358 QVRAASAPAKESPRKGAAPAPPRKTGPAAAQ 388
Score = 44.3 bits (103), Expect = 3e-04
Identities = 38/135 (28%), Positives = 57/135 (42%), Gaps = 15/135 (11%)
Query: 510 QSEEESEDTESEASEP--EDRASRKPRAKRARTAP------RGLTPAGAPPTASGARKTR 561
Q++ SEDT S + E E +AS K RA +AP +G TPA + A +T+
Sbjct: 195 QADSSSEDTSSSSDETDVEVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTK 254
Query: 562 AG-------GRGRGRGVTPEKKAGSRGSAQDDAAGSRKKKGSAGAGAHARAGEAKGQAPT 614
AG + E+ ++ Q A+G + G+A A A + AP
Sbjct: 255 AGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPP 314
Query: 615 GSKAARGKKARRGRR 629
G KA+ G+R
Sbjct: 315 GKTGPAVAKAQAGKR 329
Score = 35.8 bits (81), Expect = 0.12
Identities = 38/159 (23%), Positives = 58/159 (36%), Gaps = 18/159 (11%)
Query: 480 PKGKLGEVLALLAARENMGSNEGSEEASDEQSEEESE---DTESEASEPEDRASRKPRAK 536
P GK G +A A G E ++S E+S+ E E + P+ RA+ P
Sbjct: 313 PPGKTGPAVAKAQA----GKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAP--- 365
Query: 537 RARTAPR-GLTPAGAPPTASGARKTRAGGRGRGRGVTPEKKAGSR------GSAQDDAAG 589
A+ +PR G PA T A + + G + + E+ R +AQ G
Sbjct: 366 -AKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLG 424
Query: 590 SRKKKGSAGAGAHARAGEAKGQAPTGSKAARGKKARRGR 628
+ A G+ G P G A+ G+
Sbjct: 425 KSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGK 463
Score = 34.7 bits (78), Expect = 0.27
Identities = 34/116 (29%), Positives = 48/116 (41%), Gaps = 12/116 (10%)
Query: 509 EQSEEESEDTESEASEPEDRASRKPRAKRARTAPRGLTPAGAPPTASGARKTRAGGRGRG 568
EQ ++ DT E+S RK R R G PA P + +K AG G
Sbjct: 1247 EQERKKVVDTTKESS-------RKGWESRKRKLS-GDQPAARTPRSKKKKKLGAGEGGEA 1298
Query: 569 RGVTPEKKAG-SRGSAQDDAAGS--RKKKGSAGAGAHARAGEAKGQAPTGSKAARG 621
V+PEK + S+G A+ D A ++KKG G+ E + + G G
Sbjct: 1299 -SVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEG 1353
Score = 33.5 bits (75), Expect = 0.61
Identities = 45/148 (30%), Positives = 64/148 (43%), Gaps = 19/148 (12%)
Query: 481 KGKLGEVLALLAARENMGSNEGSEEASDEQSEEESE---------DTESEASEPEDRASR 531
K K E AL A + + + E+S+E+ E E+E T S + +S
Sbjct: 62 KRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSM 121
Query: 532 KPRAKRARTAPRGLTPAGAPPTASGARKTRAGGRGRGRGVTPEKKAGSRGSAQDDAAGSR 591
K +AK A T G T P A+G KT A G +P K A SA
Sbjct: 122 KEKAK-AETEKAGKTGNSMPHPATG--KTVANLLS---GKSPRKSA--EPSANTTLVSET 173
Query: 592 KKKGSAGA-GAHARAG-EAKGQAPTGSK 617
+++GS A GA A+ G + GQA + S+
Sbjct: 174 EEEGSVPAFGAAAKPGMVSAGQADSSSE 201
Score = 33.1 bits (74), Expect = 0.80
Identities = 114/566 (20%), Positives = 192/566 (33%), Gaps = 79/566 (13%)
Query: 112 DDGPTQAAEAGTPGEAPTPPASET-QAQDSGEVTGQAGSLLGAARNPRRGRRGRRNRTRR 170
++ ++E + E TP A QA+ SG+ + + A +PR+G
Sbjct: 259 EEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAP------- 311
Query: 171 NRLTQKGKKRSRGGRPSAPARSEAEDSSDESLGIVIEEIDQGDLSGEEDQ------SALY 224
GK + A R E SS E E Q SG+ Q A
Sbjct: 312 ---APPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKE 368
Query: 225 ATLQAAARELVRQWAPC--------------NSEGEEDGPREFLALVTVTD-KSKKEEAE 269
+ + AA R+ P +S E D RE LA + K + +
Sbjct: 369 SPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQ 428
Query: 270 KEPAGAESIRLNTKEDKNGVPDLVALLAVRDTPDEEPVDSDTSESDSQESGDQETEELDN 329
+PA + K P V + DS++S +S +S D E
Sbjct: 429 VKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVA 488
Query: 330 P---EFVAIVAYTDPSDPWAREEMLKIASVIESLGWSDEKDKRDPLRQVLSVMSKDTNGT 386
P + + + P+ A+ K V + D + S + +
Sbjct: 489 PAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSE---------SSEESSD 539
Query: 387 RVKVEEAGREVDAVVLRKAGDDGDLREC---ISTLAQPDLPP------QAKKAGRG---- 433
EEA + A + A + C +T A + P +KAG
Sbjct: 540 SADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPA 599
Query: 434 -----LFGGWSEHREDEGGLLELVALLAAQDMAEVMKEEKENAWEGGKYKYP----KGKL 484
+ GG ED E + +A + + K + +G + K KG L
Sbjct: 600 GSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAK-SVGKGLQVKAASVPVKGSL 658
Query: 485 GEVLALLAAREN---MGSNEGSEEASDEQSEEESEDTESEASEPEDRASRK-------PR 534
G+ A + + + + ++ E SEEES+ E+ AS + + S K P
Sbjct: 659 GQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPA 718
Query: 535 AKRARTAPRGLTPAGAPPTASGARKTRAGGRGRGRGVTPEKKAG-SRGSAQDDAAGSR-K 592
A RA +A ++ G TA+ K R+ + + P+ +RG A + G
Sbjct: 719 AARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVA 778
Query: 593 KKGSAGAGAHARAGEAKGQAPTGSKA 618
A G +G ++ ++ + +A
Sbjct: 779 TAAQAQTGPEEDSGSSEEESDSEEEA 804
Score = 32.7 bits (73), Expect = 1.0
Identities = 35/170 (20%), Positives = 62/170 (36%), Gaps = 24/170 (14%)
Query: 445 EGGLLELVALLAAQDMAEVM---KEEKENAWEGGKYKYPKGKLGEVLALLAARENMGSNE 501
+ +++++ L Q+ +V+ KE WE K K G+ A R
Sbjct: 1235 QASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLS----GDQPAARTPRSKKKKKL 1290
Query: 502 GSEEASDEQSEEESEDTESEASEPEDRASRKPRAKR---------ARTAPRGLTPAGAPP 552
G+ E + E T S+ D+AS + K+ A+ P G
Sbjct: 1291 GAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQKGMGT 1350
Query: 553 TASGAR--------KTRAGGRGRGRGVTPEKKAGSRGSAQDDAAGSRKKK 594
G + K ++ R + + +KK + S +D + S+KKK
Sbjct: 1351 VEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQKKK 1400
Score = 30.4 bits (67), Expect = 5.2
Identities = 33/138 (23%), Positives = 49/138 (35%), Gaps = 16/138 (11%)
Query: 502 GSEEASDEQSEEESEDTESEASEPEDRASRKPRAKRARTAPRGLTP----AGAPPTASGA 557
G EE S EE + E+E + + + S K RA AP +P A PP +G
Sbjct: 786 GPEEDSGSSEEESDSEEEAE-TLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGP 844
Query: 558 RKTRAGGRGRGRGVTPEKKAGSRGSAQDDAA-----------GSRKKKGSAGAGAHARAG 606
+AG + + E + A +A +R G A A A+A
Sbjct: 845 SAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAA 904
Query: 607 EAKGQAPTGSKAARGKKA 624
+A AR +
Sbjct: 905 STPRKARASESTARSSSS 922
>gi|239751791 PREDICTED: hypothetical protein [Homo sapiens]
Length = 650
Score = 46.6 bits (109), Expect = 7e-05
Identities = 44/187 (23%), Positives = 69/187 (36%), Gaps = 26/187 (13%)
Query: 472 WEGGKYKYPKGK------LGEVLALLAARENMGS---------NEGSEEASDEQSEEESE 516
W G K + LGE + + A E G +E S E + QS+ +
Sbjct: 129 WRGSFLKLSSSRSTRGLVLGEGVGVGAGGEGGGEGAAGAASSLSERSSERVELQSDTDDS 188
Query: 517 DT---ESEASEPEDRASRKPRAKRARTAPRGLTPAGAPPTASGARKTRAGGRGRGRGVTP 573
DT E P +SR+P + PRG PA S R+ + R +
Sbjct: 189 DTRVAEGARPRPGPTSSRRPWGRAGGLRPRGKRPARGKKRPSSQRRCSSPSAARASATSA 248
Query: 574 EKKAGSRGSAQDDAAGSRKKK--------GSAGAGAHARAGEAKGQAPTGSKAARGKKAR 625
+ AQ +A S++++ G+ G G+H +G A +G++
Sbjct: 249 PRPTAPSSVAQPSSARSQRRRAPCPHRAGGADGVGSHGARAPGEGSAGSGTERVELGPHV 308
Query: 626 RGRRLPP 632
R LPP
Sbjct: 309 RPFFLPP 315
Score = 33.9 bits (76), Expect = 0.47
Identities = 26/90 (28%), Positives = 39/90 (43%), Gaps = 10/90 (11%)
Query: 112 DDGPTQAAEAGTPGEAPTPPASETQAQDSGEVTGQAGSLLGAARNPRRGRRGRRNRTRRN 171
DD T+ AE P PT S G+AG L + P RG++ ++ R +
Sbjct: 186 DDSDTRVAEGARPRPGPT---------SSRRPWGRAGGLRPRGKRPARGKKRPSSQRRCS 236
Query: 172 RLTQKGKKRSRGGRPSAPARSEAEDSSDES 201
+ + RP+AP+ S A+ SS S
Sbjct: 237 SPSAARASATSAPRPTAPS-SVAQPSSARS 265
>gi|239746282 PREDICTED: hypothetical protein XP_002343723 [Homo
sapiens]
Length = 725
Score = 46.6 bits (109), Expect = 7e-05
Identities = 44/187 (23%), Positives = 69/187 (36%), Gaps = 26/187 (13%)
Query: 472 WEGGKYKYPKGK------LGEVLALLAARENMGS---------NEGSEEASDEQSEEESE 516
W G K + LGE + + A E G +E S E + QS+ +
Sbjct: 129 WRGSFLKLSSSRSTRGLVLGEGVGVGAGGEGGGEGAAGAASSLSERSSERVELQSDTDDS 188
Query: 517 DT---ESEASEPEDRASRKPRAKRARTAPRGLTPAGAPPTASGARKTRAGGRGRGRGVTP 573
DT E P +SR+P + PRG PA S R+ + R +
Sbjct: 189 DTRVAEGARPRPGPTSSRRPWGRAGGLRPRGKRPARGKKRPSSQRRCSSPSAARASATSA 248
Query: 574 EKKAGSRGSAQDDAAGSRKKK--------GSAGAGAHARAGEAKGQAPTGSKAARGKKAR 625
+ AQ +A S++++ G+ G G+H +G A +G++
Sbjct: 249 PRPTAPSSVAQPSSARSQRRRAPCPHRAGGADGVGSHGARAPGEGSAGSGTERVELGPHV 308
Query: 626 RGRRLPP 632
R LPP
Sbjct: 309 RPFFLPP 315
Score = 33.9 bits (76), Expect = 0.47
Identities = 26/90 (28%), Positives = 39/90 (43%), Gaps = 10/90 (11%)
Query: 112 DDGPTQAAEAGTPGEAPTPPASETQAQDSGEVTGQAGSLLGAARNPRRGRRGRRNRTRRN 171
DD T+ AE P PT S G+AG L + P RG++ ++ R +
Sbjct: 186 DDSDTRVAEGARPRPGPT---------SSRRPWGRAGGLRPRGKRPARGKKRPSSQRRCS 236
Query: 172 RLTQKGKKRSRGGRPSAPARSEAEDSSDES 201
+ + RP+AP+ S A+ SS S
Sbjct: 237 SPSAARASATSAPRPTAPS-SVAQPSSARS 265
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.308 0.128 0.359
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,329,156
Number of Sequences: 37866
Number of extensions: 1375318
Number of successful extensions: 15286
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 284
Number of HSP's successfully gapped in prelim test: 813
Number of HSP's that attempted gapping in prelim test: 10717
Number of HSP's gapped (non-prelim): 4259
length of query: 635
length of database: 18,247,518
effective HSP length: 109
effective length of query: 526
effective length of database: 14,120,124
effective search space: 7427185224
effective search space used: 7427185224
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.