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Search of human proteins with 14550409
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|14550409 cytochrome P450, family 21, subfamily A,
polypeptide 2 isoform a [Homo sapiens]
(495 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide... 1007 0.0
gi|190570174 cytochrome P450, family 21, subfamily A, polypeptid... 932 0.0
gi|4503195 cytochrome P450, family 17 [Homo sapiens] 239 4e-63
gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide ... 205 7e-53
gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide ... 198 8e-51
gi|19743565 cytochrome P450, family 2, subfamily F, polypeptide ... 192 8e-49
gi|4503199 cytochrome P450, family 1, subfamily A, polypeptide 1... 183 4e-46
gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide ... 182 8e-46
gi|40805836 cytochrome P450, family 2, subfamily D, polypeptide ... 180 2e-45
gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide ... 179 4e-45
gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide ... 177 3e-44
gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide ... 172 5e-43
gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide ... 172 5e-43
gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide ... 172 8e-43
gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 1... 171 1e-42
gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6... 161 1e-39
gi|68509921 cytochrome P450, family 2, subfamily D, polypeptide ... 159 4e-39
gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18 ... 157 2e-38
gi|73915100 cytochrome P450, family 1, subfamily A, polypeptide ... 157 2e-38
gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide... 156 4e-38
gi|189491763 cytochrome P450, family 1, subfamily B, polypeptide... 151 1e-36
gi|13699809 cytochrome P450, family 2, subfamily A, polypeptide ... 150 3e-36
gi|15147330 cytochrome P450, family 2, subfamily A, polypeptide ... 149 6e-36
gi|193083148 cytochrome P450 family 2 subfamily C polypeptide 18... 126 4e-29
gi|15147328 cytochrome P450, family 2, subfamily A, polypeptide ... 116 5e-26
gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide ... 113 3e-25
gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide ... 108 9e-24
gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide ... 107 2e-23
gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5... 102 1e-21
gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide ... 102 1e-21
>gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide 2
isoform a [Homo sapiens]
Length = 495
Score = 1007 bits (2604), Expect = 0.0
Identities = 495/495 (100%), Positives = 495/495 (100%)
Query: 1 MLLLGLLLLLPLLAGARLLWNWWKLRSLHLPPLAPGFLHLLQPDLPIYLLGLTQKFGPIY 60
MLLLGLLLLLPLLAGARLLWNWWKLRSLHLPPLAPGFLHLLQPDLPIYLLGLTQKFGPIY
Sbjct: 1 MLLLGLLLLLPLLAGARLLWNWWKLRSLHLPPLAPGFLHLLQPDLPIYLLGLTQKFGPIY 60
Query: 61 RLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDLSLGDYSLLWKAH 120
RLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDLSLGDYSLLWKAH
Sbjct: 61 RLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDLSLGDYSLLWKAH 120
Query: 121 KKLTRSALLLGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGD 180
KKLTRSALLLGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGD
Sbjct: 121 KKLTRSALLLGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGD 180
Query: 181 KIKDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQAIEKRDHIVEM 240
KIKDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQAIEKRDHIVEM
Sbjct: 181 KIKDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQAIEKRDHIVEM 240
Query: 241 QLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANT 300
QLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANT
Sbjct: 241 QLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANT 300
Query: 301 LSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVV 360
LSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVV
Sbjct: 301 LSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVV 360
Query: 361 PLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKNSRAL 420
PLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKNSRAL
Sbjct: 361 PLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKNSRAL 420
Query: 421 AFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPLPHCSVILKMQPFQVR 480
AFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPLPHCSVILKMQPFQVR
Sbjct: 421 AFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPLPHCSVILKMQPFQVR 480
Query: 481 LQPRGMGAHSPGQSQ 495
LQPRGMGAHSPGQSQ
Sbjct: 481 LQPRGMGAHSPGQSQ 495
>gi|190570174 cytochrome P450, family 21, subfamily A, polypeptide 2
isoform b [Homo sapiens]
Length = 465
Score = 932 bits (2408), Expect = 0.0
Identities = 465/495 (93%), Positives = 465/495 (93%), Gaps = 30/495 (6%)
Query: 1 MLLLGLLLLLPLLAGARLLWNWWKLRSLHLPPLAPGFLHLLQPDLPIYLLGLTQKFGPIY 60
MLLLGLLLLLPLLAGARLLWNWWKLRSLHLPPLAPGFLHLLQPDLPIYLLGLTQKFGPIY
Sbjct: 1 MLLLGLLLLLPLLAGARLLWNWWKLRSLHLPPLAPGFLHLLQPDLPIYLLGLTQKFGPIY 60
Query: 61 RLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDLSLGDYSLLWKAH 120
RLHLGLQD KLVSRNYPDLSLGDYSLLWKAH
Sbjct: 61 RLHLGLQD------------------------------KLVSRNYPDLSLGDYSLLWKAH 90
Query: 121 KKLTRSALLLGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGD 180
KKLTRSALLLGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGD
Sbjct: 91 KKLTRSALLLGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGD 150
Query: 181 KIKDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQAIEKRDHIVEM 240
KIKDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQAIEKRDHIVEM
Sbjct: 151 KIKDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQAIEKRDHIVEM 210
Query: 241 QLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANT 300
QLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANT
Sbjct: 211 QLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANT 270
Query: 301 LSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVV 360
LSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVV
Sbjct: 271 LSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVV 330
Query: 361 PLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKNSRAL 420
PLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKNSRAL
Sbjct: 331 PLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKNSRAL 390
Query: 421 AFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPLPHCSVILKMQPFQVR 480
AFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPLPHCSVILKMQPFQVR
Sbjct: 391 AFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPLPHCSVILKMQPFQVR 450
Query: 481 LQPRGMGAHSPGQSQ 495
LQPRGMGAHSPGQSQ
Sbjct: 451 LQPRGMGAHSPGQSQ 465
>gi|4503195 cytochrome P450, family 17 [Homo sapiens]
Length = 508
Score = 239 bits (610), Expect = 4e-63
Identities = 147/454 (32%), Positives = 240/454 (52%), Gaps = 34/454 (7%)
Query: 52 LTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDLSLG 111
L +K+GPIY + +G + V++ + +E ++KK DF+GRP+ T + S N ++
Sbjct: 56 LQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFA 115
Query: 112 DYSLLWKAHKKLTRS--ALLLGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLT 169
D W+ H++L + AL +E ++ Q C+ + G + I +
Sbjct: 116 DSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAV 175
Query: 170 CSIICYLTFGDKIKDD----NLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLR 225
++I + F K+ N++ Y + I + L S +VD++P+L+ FPN L
Sbjct: 176 TNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDS-----LVDLVPWLKIFPNKTLE 230
Query: 226 RLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQ-------GVAQPSMEEGSGQLL 278
+LK ++ R+ ++ L +KE + +M+D ++Q G A P ++ S L
Sbjct: 231 KLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGP--DQDSELLS 288
Query: 279 EGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVP-Y 337
+ H+ D+ G ETT + + W + FLLH+P+++++L EE+D +G SR P
Sbjct: 289 DNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVG----FSRTPTI 344
Query: 338 KDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDET 397
DR RL LL ATI EVLRLRPV P+ +PH+ SSI + + +GT +I NL H +E
Sbjct: 345 SDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEK 404
Query: 398 VWERPHEFWPDRFLEP------GKNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFT 451
W +P +F P+RFL P + L FG G R C+GE LAR ELF+++ LLQ F
Sbjct: 405 EWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFD 464
Query: 452 L-LPSGDALPSLQPLPHCSVILKMQPFQVRLQPR 484
L +P LPSL+ +P V+ + F+V+++ R
Sbjct: 465 LEVPDDGQLPSLEGIP--KVVFLIDSFKVKIKVR 496
>gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide 1
[Homo sapiens]
Length = 544
Score = 205 bits (522), Expect = 7e-53
Identities = 151/527 (28%), Positives = 250/527 (47%), Gaps = 53/527 (10%)
Query: 4 LGLLLLLP-----LLAG--ARLLWNWWKLRSLH-LPP------LAPGFLHLLQPDL---- 45
LGLL L P LL G A L W+W + R +PP L F H+L P
Sbjct: 25 LGLLRLDPSGGALLLCGLVALLGWSWLRRRRARGIPPGPTPWPLVGNFGHVLLPPFLRRR 84
Query: 46 -------------------PIYLLGLTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKW 86
+ L L + +G I+ +G VVVL+ ++ EA+V++
Sbjct: 85 SWLSSRTRAAGIDPSVIGPQVLLAHLARVYGSIFSFFIGHYLVVVLSDFHSVREALVQQA 144
Query: 87 ADFAGRPEPLTYKLVSRNYPDLSLGDYSLLWKAHKKLTRSALL---LGIRDSMEPVVEQL 143
F+ RP +V++ + Y +W+ +K + S L LG + S+EP + +
Sbjct: 145 EVFSDRPRVPLISIVTKE-KGVVFAHYGPVWRQQRKFSHSTLRHFGLG-KLSLEPKIIEE 202
Query: 144 TQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIKDDNL-MPAYYKCIQEVLKTW 202
+ M+ P S +IIC L FG + N + L+
Sbjct: 203 FKYVKAEMQKHGEDPFCPFSIISNAVSNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEIC 262
Query: 203 SHWSIQIVDVIPFLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYML 262
+ + +V++ P+L + P + L+Q + ++ ++ H+ESL +D +D L
Sbjct: 263 LNSQVLLVNICPWLYYLPFGPFKELRQIEKDITSFLKKIIKDHQESLDRENPQDFIDMYL 322
Query: 263 QGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEEL 322
+ + + E ++ DL I GT+TT N+L W ++++ +P++Q+++ EE+
Sbjct: 323 LHMEEERKNNSNSSFDEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEI 382
Query: 323 DHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEG 382
+ +G + S D+A++P ATI EV RL VVPLA+PH T+ + + GY IP+G
Sbjct: 383 ERVIGANRAPSLT---DKAQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKG 439
Query: 383 TVIIPNLQGAHLDETVWERPHEFWPDRFLEPG----KNSRALAFGCGARVCLGEPLARLE 438
T+I+PNL H D +WE+P +F+P+RFL+ K + FG G RVC+GE LA++E
Sbjct: 440 TLILPNLWSVHRDPAIWEKPEDFYPNRFLDDQGQLIKKETFIPFGIGKRVCMGEQLAKME 499
Query: 439 LFVVLTRLLQAFTL-LPSGDALPSLQPLPHCSVILKMQPFQVRLQPR 484
LF++ L+Q+F LP P L + L PF + + R
Sbjct: 500 LFLMFVSLMQSFAFALPEDSKKPLL--TGRFGLTLAPHPFNITISRR 544
>gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide 2
[Homo sapiens]
Length = 502
Score = 198 bits (504), Expect = 8e-51
Identities = 130/419 (31%), Positives = 217/419 (51%), Gaps = 18/419 (4%)
Query: 54 QKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRP-EPLTYKLVSRNYPDLSLGD 112
+K+G ++ L LG V++ I+EA++ +F RP P+ + +N +S G
Sbjct: 73 KKYGNLFSLELGDISAVLITGLPLIKEALIHMDQNFGNRPVTPMREHIFKKNGLIMSSGQ 132
Query: 113 YSLLWKAHKKLTRSALL---LGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLT 169
WK ++ T +AL LG + S+E +++ Q E ++ + G P + +
Sbjct: 133 ---AWKEQRRFTLTALRNFGLG-KKSLEERIQEEAQHLTEAIKEENGQPFDPHFKINNAV 188
Query: 170 CSIICYLTFGDKIK-DDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFL-RFFPNPGLRRL 227
+IIC +TFG++ + D+ K + EV + + Q+ +V P++ +F P P + L
Sbjct: 189 SNIICSITFGERFEYQDSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLPGPH-QTL 247
Query: 228 KQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAV 287
+K V + +H++ + RD +D L+ +++ + S E ++ + +
Sbjct: 248 FSNWKKLKLFVSHMIDKHRKDWNPAETRDFIDAYLKEMSKHTGNPTSS-FHEENLICSTL 306
Query: 288 DLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLN 347
DL GTETT+ TL WA++++ +PEIQ+++Q E+D +G G S R +P N
Sbjct: 307 DLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAA---RESMPYTN 363
Query: 348 ATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWP 407
A I EV R+ ++PL +P T ++++GY +P+GT+I+ NL H D T W P F P
Sbjct: 364 AVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNP 423
Query: 408 DRFLEPG---KNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQ 463
D FLE G K + F G R CLGE LAR ELF+ T L+Q FT P + SL+
Sbjct: 424 DHFLENGQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKLSLK 482
>gi|19743565 cytochrome P450, family 2, subfamily F, polypeptide 1
[Homo sapiens]
Length = 491
Score = 192 bits (487), Expect = 8e-49
Identities = 158/500 (31%), Positives = 249/500 (49%), Gaps = 39/500 (7%)
Query: 8 LLLPLLAGARLLWNWWKLRSLHLPP------LAPGFLHLLQPDLPIYLLGLTQKFGPIYR 61
+LL LLA LL LPP + L L D+ L L++++G +Y
Sbjct: 8 ILLLLLALVCLLLTLSSRDKGKLPPGPRPLSILGNLLLLCSQDMLTSLTKLSKEYGSMYT 67
Query: 62 LHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPE-PLTYKLVSRNYPDLSLGDYSLLWKAH 120
+HLG + VVVL+ + ++EA+V + +F+GR + P + N S GD WK
Sbjct: 68 VHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPAFFNFTKGNGIAFSSGDR---WKVL 124
Query: 121 KKLTRSALL---LGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLT 177
++ + L +G R E ++E+ + E +R G P S +IIC +
Sbjct: 125 RQFSIQILRNFGMGKRSIEERILEEGSFLLAE-LRKTEGEPFDPTFVLSRSVSNIICSVL 183
Query: 178 FGDKIK-DDNLMPAYYKCIQEVLKTWSHWSIQIVDVIP-FLRFFPNPGLRRLKQAIEKRD 235
FG + DD + + I + + S ++ D+ P L + P P R + RD
Sbjct: 184 FGSRFDYDDERLLTIIRLINDNFQIMSSPWGELYDIFPSLLDWVPGPHQRIFQNFKCLRD 243
Query: 236 HIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAV-----DLL 290
++ + H+ SL RD + L +A+ + S H HM + +LL
Sbjct: 244 -LIAHSVHDHQASLDPRSPRDFIQCFLTKMAEEKEDPLS------HFHMDTLLMTTHNLL 296
Query: 291 IGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVP-YKDRARLPLLNAT 349
GGT+T + TL A + L+ +P++Q R+QEE+D +G +R+P KDRA +P +A
Sbjct: 297 FGGTKTVSTTLHHAFLALMKYPKVQARVQEEIDLVVG----RARLPALKDRAAMPYTDAV 352
Query: 350 IAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDR 409
I EV R ++P+ LPHR TR ++ G+ IP+GT +I L H D + + P EF P+
Sbjct: 353 IHEVQRFADIIPMNLPHRVTRDTAFRGFLIPKGTDVITLLNTVHYDPSQFLTPQEFNPEH 412
Query: 410 FLEPG----KNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPL 465
FL+ K+ + F G R+CLGE LAR+ELF+ LT +LQ+F+L P G A +
Sbjct: 413 FLDANQSFKKSPAFMPFSAGRRLCLGESLARMELFLYLTAILQSFSLQPLG-APEDIDLT 471
Query: 466 PHCSVILKM-QPFQVRLQPR 484
P S + + +PFQ+ L+PR
Sbjct: 472 PLSSGLGNLPRPFQLCLRPR 491
>gi|4503199 cytochrome P450, family 1, subfamily A, polypeptide 1
[Homo sapiens]
Length = 512
Score = 183 bits (464), Expect = 4e-46
Identities = 123/425 (28%), Positives = 207/425 (48%), Gaps = 42/425 (9%)
Query: 52 LTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDLSLG 111
++Q++G + ++ +G VVVL+ TI +A+V++ DF GRP+ T+ L+S
Sbjct: 66 MSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSP 125
Query: 112 DYSLLWKAHKKLTRSALL-------------LGIRDSMEPVVEQLTQEFCERMRAQPGTP 158
D +W A ++L ++ L + + + E L E M A PG
Sbjct: 126 DSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELM-AGPGHF 184
Query: 159 VAIEEEFSLLTCSIICYLTFGDKIKDDNLMPAYYKCIQEVLKTWSH--------WSIQIV 210
+T ++IC + FG + ++ QE+L + S
Sbjct: 185 NPYRYVVVSVT-NVICAICFGRRYDHNH---------QELLSLVNLNNNFGEVVGSGNPA 234
Query: 211 DVIPFLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSM 270
D IP LR+ PNP L K EK ++ +++H ++ G RD+ D +++ + +
Sbjct: 235 DFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQL 294
Query: 271 EEGSG-QLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPG 329
+E + QL + + +DL G +T +SW++++L+ +P +Q+++QEELD +G
Sbjct: 295 DENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIG-- 352
Query: 330 ASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNL 389
S R DR+ LP + A I E R VP +PH TTR +S+ G+ IP+G + N
Sbjct: 353 -RSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQ 411
Query: 390 QGAHLDETVWERPHEFWPDRFLEPG------KNSRALAFGCGARVCLGEPLARLELFVVL 443
+ D+ +W P EF P+RFL P + + + FG G R C+GE +AR E+F+ L
Sbjct: 412 WQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFL 471
Query: 444 TRLLQ 448
LLQ
Sbjct: 472 AILLQ 476
>gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide 1
[Homo sapiens]
Length = 501
Score = 182 bits (461), Expect = 8e-46
Identities = 151/507 (29%), Positives = 233/507 (45%), Gaps = 48/507 (9%)
Query: 5 GLLLLLPLLAGARLLWNWWKLRSLHLPPLAPGFLHL-------LQPDLP-IYLLGLTQKF 56
G L LL G R L + R + PP PG + +LP +Y+ +Q +
Sbjct: 16 GALFLLLFALGVRQLLK--QRRPMGFPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVY 73
Query: 57 GPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRP-EPLTYKLVSRNYPDLSLGDYSL 115
G I+ L LG VVLN ++E +V + FA RP PL K+ L Y
Sbjct: 74 GEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMG--GLLNSRYGR 131
Query: 116 LWKAHKKLT-RSALLLGI-RDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSII 173
W H++L S G + S E + + T+ F + + G P ++ + +I
Sbjct: 132 GWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNIT 191
Query: 174 CYLTFGDKIK-DDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFP---NPGLRR--- 226
+ FG++ +D + E ++ + S+ + + P++ P + L R
Sbjct: 192 NLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAA 251
Query: 227 -----LKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGH 281
L + IEK + QL QH + D MD QG PS L+
Sbjct: 252 VVYDFLSRLIEKASVNRKPQLPQH----FVDAYLDEMD---QGKNDPSSTFSKENLI--- 301
Query: 282 VHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRA 341
+ +L+I GTETT N L WA++F+ +P IQ ++Q+E+D +GP S + D+
Sbjct: 302 --FSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPS---WDDKC 356
Query: 342 RLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWER 401
++P A + EVLR +VPL + H T+ + + GY IP+GT +I NL H DE W
Sbjct: 357 KMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRD 416
Query: 402 PHEFWPDRFLEP----GKNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGD 457
P F P+RFL+ K + F G R CLGE LAR+E+F+ T LLQ F L +
Sbjct: 417 PEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHE 476
Query: 458 ALPSLQPLPHCSVILKMQPFQVRLQPR 484
+P L+ P + L+ QP+ + + R
Sbjct: 477 LVPDLK--PRLGMTLQPQPYLICAERR 501
>gi|40805836 cytochrome P450, family 2, subfamily D, polypeptide 6
isoform 1 [Homo sapiens]
Length = 497
Score = 180 bits (457), Expect = 2e-45
Identities = 143/462 (30%), Positives = 217/462 (46%), Gaps = 37/462 (8%)
Query: 23 WKLRSLHLPPLAPGFLHLLQPDL---PIYLLGLTQKFGPIYRLHLGLQDVVVLNSKRTIE 79
W R P PG +LL D P L ++FG ++ L L VVVLN +
Sbjct: 29 WAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVR 88
Query: 80 EAMVKKWADFAGRPE-PLTYKL-VSRNYPDLSLGDYSLLWKAHKKLTRSALL-LGI-RDS 135
EA+V D A RP P+T L + L Y W+ ++ + S L LG+ + S
Sbjct: 89 EALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKS 148
Query: 136 MEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIKDDNLMPAYYKCI 195
+E V + C G P ++I LT G + + D+ P + + +
Sbjct: 149 LEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDD--PRFLRLL 206
Query: 196 ---QEVLKTWSHWSIQIVDVIPFLRFFP---NPGLRRLKQAIEKRDHIVEMQLRQHKESL 249
QE LK S + ++++ +P L P LR K + + D + L +H+ +
Sbjct: 207 DLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDEL----LTEHRMTW 262
Query: 250 VAGQW-RDMMDYMLQGVAQPSMEEGSGQ----LLEGHVHMAAVDLLIGGTETTANTLSWA 304
Q RD+ + L ME+ G + ++ + DL G TT+ TL+W
Sbjct: 263 DPAQPPRDLTEAFLA-----EMEKAKGNPESSFNDENLCIVVADLFSAGMVTTSTTLAWG 317
Query: 305 VVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLAL 364
++ ++ HP++Q+R+Q+E+D +G R D+A +P A I EV R +VPL +
Sbjct: 318 LLLMILHPDVQRRVQQEIDDVIG---QVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGV 374
Query: 365 PHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPG----KNSRAL 420
H T+R + G+ IP+GT +I NL DE VWE+P F P+ FL+ K L
Sbjct: 375 THMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFL 434
Query: 421 AFGCGARVCLGEPLARLELFVVLTRLLQAFTL-LPSGDALPS 461
F G R CLGEPLAR+ELF+ T LLQ F+ +P+G PS
Sbjct: 435 PFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPS 476
>gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide 1
[Homo sapiens]
Length = 493
Score = 179 bits (455), Expect = 4e-45
Identities = 136/482 (28%), Positives = 234/482 (48%), Gaps = 42/482 (8%)
Query: 1 MLLLGLLLLLPLLAGARLLWNWWKL--RSLHLPP------LAPGFLHLLQPDLPIYLLGL 52
M LG+ + L + A LL + W+ S +LPP + L ++P L
Sbjct: 1 MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRL 60
Query: 53 TQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYK------LVSRNYP 106
Q+FGP++ L++G Q +VV++ + ++EA++ +F+GR + + ++ N P
Sbjct: 61 AQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGP 120
Query: 107 DLSLGDYSLLWKAHKKLTRSALL---LGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEE 163
WK ++ + + L +G + E +++ E +R G P
Sbjct: 121 T---------WKDIRRFSLTTLRNYGMG-KQGNESRIQREAHFLLEALRKTQGQPFDPTF 170
Query: 164 EFSLLTCSIICYLTFGDKI--KDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIP-FLRFFP 220
C++I + F D+ + Y + + W +Q+ + P FL + P
Sbjct: 171 LIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPW-LQLYNNFPSFLHYLP 229
Query: 221 NPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEG 280
+ +K E ++++ E ++++H +SL RD+ D +L + + ++G
Sbjct: 230 GSHRKVIKNVAEVKEYVSE-RVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDG 288
Query: 281 HVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVP-YKD 339
+ + DL GTETT+ TL + ++ L+ +PEI+++L EE+D +GP SR+P KD
Sbjct: 289 -ITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGP----SRIPAIKD 343
Query: 340 RARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVW 399
R +P ++A + E+ R +VP LPH TR + GY IP+GTV++P L D +
Sbjct: 344 RQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEF 403
Query: 400 ERPHEFWPDRFL-EPGK---NSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPS 455
P +F P+ FL E GK + F G RVC GE LAR+ELF++L +LQ F L P
Sbjct: 404 PDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPL 463
Query: 456 GD 457
D
Sbjct: 464 VD 465
>gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide 1
[Homo sapiens]
Length = 504
Score = 177 bits (448), Expect = 3e-44
Identities = 157/518 (30%), Positives = 252/518 (48%), Gaps = 46/518 (8%)
Query: 1 MLLLGLLLLLPL-LAGARLLWNWWKLRSLHLPP------LAPGFLHLLQPDLPIYLLGLT 53
+L L LLLLL L L+G R HLPP L L L L L+ L+
Sbjct: 10 LLALALLLLLTLALSGTRARG--------HLPPGPTPLPLLGNLLQLRPGALYSGLMRLS 61
Query: 54 QKFGPIYRLHLG-LQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPD----L 108
+K+GP++ ++LG + VVVL + + EA+ + +F+GR T ++ +
Sbjct: 62 KKYGPVFTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRG---TVAMLEGTFDGHGVFF 118
Query: 109 SLGDYSLLWKAHKKLTRSALL---LGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEF 165
S G+ W+ +K T AL +G R+ E +++ + E + G P
Sbjct: 119 SNGER---WRQLRKFTMLALRDLGMGKREG-EELIQAEARCLVETFQGTEGRPFDPSLLL 174
Query: 166 SLLTCSIICYLTFGDKIK-DDNLMPAYYKCIQEVLKTWSHWSIQIVDVIP-FLRFFPNPG 223
+ T +++C L FG + +D A + L S Q ++ FLR P P
Sbjct: 175 AQATSNVVCSLLFGLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLPGPH 234
Query: 224 LRRLKQAIEKRDHIVEMQLRQHKESLVA-GQWRDMMDYMLQGVAQPSMEEGSGQLLEGHV 282
++L + Q++QH+ +L A G RD++D L +AQ G+ + ++
Sbjct: 235 -KQLLHHVSTLAAFTVRQVQQHQGNLDASGPARDLVDAFLLKMAQEEQNPGT-EFTNKNM 292
Query: 283 HMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRAR 342
M + LL GT T + T+ + ++ L+ +P +Q+ ++EEL+ ELG G + S DR R
Sbjct: 293 LMTVIYLLFAGTMTVSTTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPS---LGDRTR 349
Query: 343 LPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERP 402
LP +A + E RL +VP+ +P R + GY +P+GT + P L D +++ P
Sbjct: 350 LPYTDAVLHEAQRLLALVPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHP 409
Query: 403 HEFWPDRFLEPG----KNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDA 458
EF PDRFL+ K+ L F G RVCLGE LA+ ELF+ T +LQAF+ L S
Sbjct: 410 EEFNPDRFLDADGRFRKHEAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFS-LESPCP 468
Query: 459 LPSLQPLPHCSVILKMQP-FQVRLQPRGMGAHSPGQSQ 495
+L P S + + P FQ++++P + HS Q++
Sbjct: 469 PDTLSLKPTVSGLFNIPPAFQLQVRPTDL--HSTTQTR 504
>gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide 9
[Homo sapiens]
Length = 490
Score = 172 bits (437), Expect = 5e-43
Identities = 132/466 (28%), Positives = 224/466 (48%), Gaps = 31/466 (6%)
Query: 7 LLLLPLLAGARLLWNWWKLRSLH--LPP------LAPGFLHLLQPDLPIYLLGLTQKFGP 58
L++L L LL + W+ S LPP + L + D+ L L++ +GP
Sbjct: 4 LVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGP 63
Query: 59 IYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDLSLGDYSLLWK 118
++ L+ GL+ +VVL+ ++EA++ +F+GR + L R + G K
Sbjct: 64 VFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRG---IFPLAER--ANRGFGIVFSNGK 118
Query: 119 AHKKLTRSALL------LGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSI 172
K++ R +L+ +G R S+E V++ + E +R +P C++
Sbjct: 119 KWKEIRRFSLMTLRNFGMGKR-SIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNV 177
Query: 173 ICYLTFGDKI--KDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQA 230
IC + F + KD + K + + S W + P + +FP + LK
Sbjct: 178 ICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNV 237
Query: 231 IEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLL 290
+ +I+E ++++H+ES+ +D +D L + + + S +E + AVDL
Sbjct: 238 AFMKSYILE-KVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIES-LENTAVDLF 295
Query: 291 IGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATI 350
GTETT+ TL +A++ LL HPE+ ++QEE++ +G S +DR+ +P +A +
Sbjct: 296 GAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCM---QDRSHMPYTDAVV 352
Query: 351 AEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRF 410
EV R ++P +LPH T Y IP+GT I+ +L D + P F P F
Sbjct: 353 HEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHF 412
Query: 411 LEPGKNSRA----LAFGCGARVCLGEPLARLELFVVLTRLLQAFTL 452
L+ G N + + F G R+C+GE LA +ELF+ LT +LQ F L
Sbjct: 413 LDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNL 458
>gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide 1
[Homo sapiens]
Length = 490
Score = 172 bits (437), Expect = 5e-43
Identities = 137/443 (30%), Positives = 215/443 (48%), Gaps = 36/443 (8%)
Query: 36 GFLHLLQ-PDLPIYLLGLTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPE 94
G LHLL+ L+ L++++GP++ +HLG Q VVL ++EA+ + A RP
Sbjct: 42 GNLHLLRLSQQDRSLMELSERYGPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRPP 101
Query: 95 PLTYKLVSRNYPDLSLGDYSLLWKAHKKLTRSAL-LLGIRDSMEPVVEQLTQEF------ 147
++L+ R W+A ++ T AL LG+ EPV +++ QE
Sbjct: 102 IAIFQLIQRGGGIFFSS--GARWRAARQFTVRALHSLGV--GREPVADKILQELKCLSGQ 157
Query: 148 CERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIK-DDNLMPAYYKCIQEVLKTWSHWS 206
+ R +P P+A+ +I L FG + D + + I EV+
Sbjct: 158 LDGYRGRP-FPLAL---LGWAPSNITFALLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPG 213
Query: 207 IQIVDVIPFLRFF---PNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQ 263
+Q+ +V P+L P LR+ IE+ I+ L + + G + Y+
Sbjct: 214 LQLFNVYPWLGALLQLHRPVLRK----IEEVRAILRTLLEARRPHVCPGD--PVCSYVDA 267
Query: 264 GVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELD 323
+ Q ++ G E + +D+++ GTETT+ TL WA + + HP++Q R+QEELD
Sbjct: 268 LIQQGQGDDPEGLFAEANAVACTLDMVMAGTETTSATLQWAALLMGRHPDVQGRVQEELD 327
Query: 324 HELGPGASSSRVP-YKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEG 382
LGPG R P +D+ LP +A + EV R ++P +P T + + G+ +P+G
Sbjct: 328 RVLGPG----RTPRLEDQQALPYTSAVLHEVQRFITLLP-HVPRCTAADTQLGGFLLPKG 382
Query: 383 TVIIPNLQGAHLDETVWERPHEFWPDRFLEPG----KNSRALAFGCGARVCLGEPLARLE 438
T +IP L LDET W+ P +F P FL+ K L F G RVC+GE LAR E
Sbjct: 383 TPVIPLLTSVLLDETQWQTPGQFNPGHFLDANGHFVKREAFLPFSAGRRVCVGERLARTE 442
Query: 439 LFVVLTRLLQAFTLLPSGDALPS 461
LF++ LLQ + LLP P+
Sbjct: 443 LFLLFAGLLQRYRLLPPPGVSPA 465
>gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide 8
[Homo sapiens]
Length = 490
Score = 172 bits (435), Expect = 8e-43
Identities = 139/491 (28%), Positives = 230/491 (46%), Gaps = 36/491 (7%)
Query: 8 LLLPLLAGARLLWNWWK--LRSLHLPP------LAPGFLHLLQPDLPIYLLGLTQKFGPI 59
++L L LL++ W+ R LPP + L + D+ ++ +GP+
Sbjct: 5 VVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPV 64
Query: 60 YRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPE-PLTYKLVSRNYPDLSLGDYSLLWK 118
+ ++ G+ +VV + ++EA++ +F+GR P++ ++ LG S K
Sbjct: 65 FTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITK------GLGIISSNGK 118
Query: 119 AHKKLTRSALL------LGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSI 172
K++ R +L +G R S+E V++ E +R +P C++
Sbjct: 119 RWKEIRRFSLTTLRNFGMGKR-SIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNV 177
Query: 173 ICYLTFGDKI--KDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFL-RFFPNPGLRRLKQ 229
IC + F + KD N + + + S W IQ+ + P L FP + LK
Sbjct: 178 ICSVVFQKRFDYKDQNFLTLMKRFNENFRILNSPW-IQVCNNFPLLIDCFPGTHNKVLKN 236
Query: 230 AIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDL 289
R +I E ++++H+ SL RD +D L + Q + S +E V A DL
Sbjct: 237 VALTRSYIRE-KVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVA-DL 294
Query: 290 LIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNAT 349
+ GTETT+ TL + ++ LL HPE+ ++QEE+DH +G S +DR+ +P +A
Sbjct: 295 FVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPC---MQDRSHMPYTDAV 351
Query: 350 IAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDR 409
+ E+ R +VP +PH T + Y IP+GT I+ L D+ + P+ F P
Sbjct: 352 VHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGH 411
Query: 410 FLEPGKNSRA----LAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPL 465
FL+ N + + F G R+C GE LAR+ELF+ LT +LQ F L S D L +L
Sbjct: 412 FLDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFN-LKSVDDLKNLNTT 470
Query: 466 PHCSVILKMQP 476
I+ + P
Sbjct: 471 AVTKGIVSLPP 481
>gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 19
[Homo sapiens]
Length = 490
Score = 171 bits (434), Expect = 1e-42
Identities = 127/434 (29%), Positives = 214/434 (49%), Gaps = 25/434 (5%)
Query: 32 PLAPGFLHLLQPDLPIYLLGLTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAG 91
P+ L + D+ L L++ +GP++ L+ GL+ +VVL+ ++EA++ +F+G
Sbjct: 37 PVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSG 96
Query: 92 RPEPLTYKLVSRNYPDLSLGDYSLLWKAHKKLTRSALL------LGIRDSMEPVVEQLTQ 145
R + +R + G K K++ R +L+ +G R S+E V++ +
Sbjct: 97 RGHFPLAERANRGF-----GIVFSNGKRWKEIRRFSLMTLRNFGMGKR-SIEDRVQEEAR 150
Query: 146 EFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKI--KDDNLMPAYYKCIQEVLKTWS 203
E +R +P C++IC + F + KD + K + + +
Sbjct: 151 CLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVST 210
Query: 204 HWSIQIVDVIP-FLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYML 262
W IQI + P + +FP + LK I+E ++++H+ES+ RD +D L
Sbjct: 211 PW-IQICNNFPTIIDYFPGTHNKLLKNLAFMESDILE-KVKEHQESMDINNPRDFIDCFL 268
Query: 263 QGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEEL 322
+ + + S +E V + A DLL GTETT+ TL +A++ LL HPE+ ++QEE+
Sbjct: 269 IKMEKEKQNQQSEFTIENLV-ITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEI 327
Query: 323 DHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEG 382
+ +G S +DR +P +A + EV R ++P +LPH T Y IP+G
Sbjct: 328 ERVIGRNRSPCM---QDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKG 384
Query: 383 TVIIPNLQGAHLDETVWERPHEFWPDRFLEPG----KNSRALAFGCGARVCLGEPLARLE 438
T I+ +L D + P F P FL+ G K++ + F G R+C+GE LAR+E
Sbjct: 385 TTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARME 444
Query: 439 LFVVLTRLLQAFTL 452
LF+ LT +LQ F L
Sbjct: 445 LFLFLTFILQNFNL 458
>gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6
[Homo sapiens]
Length = 491
Score = 161 bits (407), Expect = 1e-39
Identities = 144/507 (28%), Positives = 243/507 (47%), Gaps = 44/507 (8%)
Query: 4 LGLLLLLPLLAGARLLWNWWKLRSLH------LPP---LAPGFLHLLQPD---LPIYLLG 51
L +LL L LL G LL L H LPP P +LLQ D L L
Sbjct: 3 LSVLLFLALLTGLLLL-----LVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLR 57
Query: 52 LTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDLSLG 111
+K+G ++ +HLG + VV+L I EA+V K F+GR + R Y +
Sbjct: 58 FREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFAN 117
Query: 112 DYSLLWKAHKKLTRSALL---LGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLL 168
WK ++ + + + +G R S+E +++ Q E +R G + F +
Sbjct: 118 GNR--WKVLRRFSVTTMRDFGMGKR-SVEERIQEEAQCLIEELRKSKGALMDPTFLFQSI 174
Query: 169 TCSIICYLTFGDKIKDDNLMPAYYKCIQEVLKTWSHWSI---QIVDVIP-FLRFFPNPGL 224
T +IIC + FG + + + K + +T+S S Q+ ++ FL++FP
Sbjct: 175 TANIICSIVFGKRFHYQD--QEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAH- 231
Query: 225 RRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMD-YMLQGVAQPSMEEGSGQLLEGHVH 283
R++ + +++ + + + +H+E+L +D++D Y+L + S + +++
Sbjct: 232 RQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKS--NAHSEFSHQNLN 289
Query: 284 MAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVP-YKDRAR 342
+ + L GTETT+ TL + + +L +P + +R+ E++ +GP R P DRA+
Sbjct: 290 LNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGP----HRPPELHDRAK 345
Query: 343 LPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERP 402
+P A I E+ R ++P+ +PH T+ +S GY IP+ T + L A D +E+P
Sbjct: 346 MPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKP 405
Query: 403 HEFWPDRFLEPG----KNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDA 458
F PD FL+ K + F G R+CLGE +AR ELF+ T +LQ F+ + S A
Sbjct: 406 DAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFS-MASPVA 464
Query: 459 LPSLQPLPHCSVILKMQP-FQVRLQPR 484
+ P + K+ P +Q+R PR
Sbjct: 465 PEDIDLTPQECGVGKIPPTYQIRFLPR 491
>gi|68509921 cytochrome P450, family 2, subfamily D, polypeptide 6
isoform 2 [Homo sapiens]
Length = 446
Score = 159 bits (403), Expect = 4e-39
Identities = 135/459 (29%), Positives = 206/459 (44%), Gaps = 82/459 (17%)
Query: 23 WKLRSLHLPPLAPGFLHLLQPDL---PIYLLGLTQKFGPIYRLHLGLQDVVVLNSKRTIE 79
W R P PG +LL D P L ++FG ++ L L VVVLN +
Sbjct: 29 WAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVR 88
Query: 80 EAMVKKWADFAGRPE-PLTYKLVSRNYPDLSLGDYSLLWKAHKKLTRSALLLGIRDSMEP 138
EA+V D A RP P+T +LG
Sbjct: 89 EALVTHGEDTADRPPVPITQ------------------------------ILG------- 111
Query: 139 VVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIKDDNLMPAYYKCI--- 195
F R + +P P + ++ ++I LT G + + D+ P + + +
Sbjct: 112 --------FGPRSQGRPFRPNGLLDK---AVSNVIASLTCGRRFEYDD--PRFLRLLDLA 158
Query: 196 QEVLKTWSHWSIQIVDVIPFLRFFP---NPGLRRLKQAIEKRDHIVEMQLRQHKESLVAG 252
QE LK S + ++++ +P L P LR K + + D + L +H+ +
Sbjct: 159 QEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDEL----LTEHRMTWDPA 214
Query: 253 QW-RDMMDYMLQGVAQPSMEEGSGQ----LLEGHVHMAAVDLLIGGTETTANTLSWAVVF 307
Q RD+ + L ME+ G + ++ + DL G TT+ TL+W ++
Sbjct: 215 QPPRDLTEAFLA-----EMEKAKGNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLL 269
Query: 308 LLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHR 367
++ HP++Q+R+Q+E+D +G R D+A +P A I EV R +VPL + H
Sbjct: 270 MILHPDVQRRVQQEIDDVIG---QVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHM 326
Query: 368 TTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPG----KNSRALAFG 423
T+R + G+ IP+GT +I NL DE VWE+P F P+ FL+ K L F
Sbjct: 327 TSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFS 386
Query: 424 CGARVCLGEPLARLELFVVLTRLLQAFTL-LPSGDALPS 461
G R CLGEPLAR+ELF+ T LLQ F+ +P+G PS
Sbjct: 387 AGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPS 425
>gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18
isoform 1 [Homo sapiens]
Length = 490
Score = 157 bits (398), Expect = 2e-38
Identities = 121/438 (27%), Positives = 213/438 (48%), Gaps = 33/438 (7%)
Query: 32 PLAPGFLHLLQPDLPIYLLGLTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAG 91
P+ L L D+ L ++ +GP++ ++ GL+ +VVL+ ++EA++ +F+G
Sbjct: 37 PIIGNILQLDVKDMSKSLTNFSKVYGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSG 96
Query: 92 RPE-PLTYKLVSRNYPDLSLGDYSLLWKAHKKLTRSALL------LGIRDSMEPVVEQLT 144
R P+ K+ + LG K K++ R L+ +G R S+E V++
Sbjct: 97 RGSFPVAEKV------NKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKR-SIEDRVQEEA 149
Query: 145 QEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKI--KDD---NLMPAYYKCIQEVL 199
+ E +R +P C++IC + F D+ KD NLM + + ++ +
Sbjct: 150 RCLVEELRKTNASPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEKFNENLRILS 209
Query: 200 KTWSHWSIQIVDVIPFL-RFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMM 258
W IQ+ + P L + P + + + +++E ++++H+ESL RD +
Sbjct: 210 SPW----IQVCNNFPALIDYLPGSHNKIAENFAYIKSYVLE-RIKEHQESLDMNSARDFI 264
Query: 259 DYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRL 318
D L + Q + S +E + D+ GTETT+ TL + ++ LL +PE+ ++
Sbjct: 265 DCFLIKMEQEKHNQQSEFTVESLI-ATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKV 323
Query: 319 QEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYD 378
QEE++ +G S +DR+ +P +A + E+ R ++P LPH T Y
Sbjct: 324 QEEIECVVGRNRSPCM---QDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYL 380
Query: 379 IPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKNSRA----LAFGCGARVCLGEPL 434
IP+GT II +L ++ + P F P FL+ N + + F G R+C+GE L
Sbjct: 381 IPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMGEGL 440
Query: 435 ARLELFVVLTRLLQAFTL 452
AR+ELF+ LT +LQ F L
Sbjct: 441 ARMELFLFLTTILQNFNL 458
>gi|73915100 cytochrome P450, family 1, subfamily A, polypeptide 2
[Homo sapiens]
Length = 516
Score = 157 bits (397), Expect = 2e-38
Identities = 113/416 (27%), Positives = 202/416 (48%), Gaps = 25/416 (6%)
Query: 52 LTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDLSLG 111
++Q++G + ++ +G V+VL+ TI +A+V++ DF GRP+ T L++
Sbjct: 68 MSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFST 127
Query: 112 DYSLLWKAHKKLTRSAL-LLGIRDS--------MEPVVEQLTQEFCERMRAQPGTPVAIE 162
D +W A ++L ++AL I +E V + + R++ P +
Sbjct: 128 DSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFD 187
Query: 163 --EEFSLLTCSIICYLTFGDKIKDDN-LMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFF 219
+ + ++I + FG + + M + K E ++T S S +D P LR+
Sbjct: 188 PYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETAS--SGNPLDFFPILRYL 245
Query: 220 PNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLE 279
PNP L+R K ++ ++ +++H + RD+ + + + G+ E
Sbjct: 246 PNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQE 305
Query: 280 GHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKD 339
V++ D+ G +T +SW++++L+ PEIQ+++Q+ELD +G R D
Sbjct: 306 KIVNLVN-DIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIG---RERRPRLSD 361
Query: 340 RARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVW 399
R +LP L A I E R +P +PH TTR ++++G+ IP+ + N + D +W
Sbjct: 362 RPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELW 421
Query: 400 ERPHEFWPDRFL-------EPGKNSRALAFGCGARVCLGEPLARLELFVVLTRLLQ 448
E P EF P+RFL + + + FG G R C+GE LA+ E+F+ L LLQ
Sbjct: 422 EDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQ 477
>gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide 6
[Homo sapiens]
Length = 494
Score = 156 bits (395), Expect = 4e-38
Identities = 124/471 (26%), Positives = 228/471 (48%), Gaps = 27/471 (5%)
Query: 1 MLLLGLLLLLPLLAGARLLWNWWKLRSLHLPPLAP-------GFLHLLQPDLPIYLLGLT 53
MLL+ LL+ L ++ L+ W + +S P P +L L + L+ ++
Sbjct: 6 MLLVALLVCLTVMV---LMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKIS 62
Query: 54 QKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDL-SLGD 112
+++GP++ +HLG + VVVL + EA+V + +F+GR E T+ V + Y + S G+
Sbjct: 63 ERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGE 122
Query: 113 YSLLWKAHKKLTRSALLLGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSI 172
+ + T +G R E + E+ + +R G + S ++
Sbjct: 123 RAKQLRRFSIATLRDFGVGKRGIEERIQEE-AGFLIDALRGTGGANIDPTFFLSRTVSNV 181
Query: 173 ICYLTFGDKI--KDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIP-FLRFFPNPGLRRLKQ 229
I + FGD+ KD + + + + + + S + Q+ ++ ++ P P + Q
Sbjct: 182 ISSIVFGDRFDYKDKEFL-SLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAF-Q 239
Query: 230 AIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDL 289
++ + + ++ ++ +L RD +D L + + + L+ V M ++L
Sbjct: 240 LLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLV-MTTLNL 298
Query: 290 LIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVP-YKDRARLPLLNA 348
IGGTET + TL + + L+ HPE++ ++ EE+D +G +R P ++DRA++P + A
Sbjct: 299 FIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIG----KNRQPKFEDRAKMPYMEA 354
Query: 349 TIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPD 408
I E+ R V+P++L R + + + +P+GT + P L D + + P +F P
Sbjct: 355 VIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQ 414
Query: 409 RFL-EPG---KNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPS 455
FL E G K+ + F G R C GE LAR+ELF+ T ++Q F L S
Sbjct: 415 HFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSS 465
>gi|189491763 cytochrome P450, family 1, subfamily B, polypeptide 1
[Homo sapiens]
Length = 543
Score = 151 bits (382), Expect = 1e-36
Identities = 137/484 (28%), Positives = 228/484 (47%), Gaps = 62/484 (12%)
Query: 6 LLLLLPLLA----GARLLWNWWKLRSLHLPPLAP------GFLHLLQPDLPIYLLGLTQK 55
LLLLL +LA G RLL + R L P P G + + L ++
Sbjct: 23 LLLLLSVLATVHVGQRLLRQ--RRRQLRSAPPGPFAWPLIGNAAAVGQAAHLSFARLARR 80
Query: 56 FGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDLSLGDYSL 115
+G ++++ LG +VVLN +R I +A+V++ + FA RP ++++VS ++ G YS
Sbjct: 81 YGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPAFASFRVVSGGR-SMAFGHYSE 139
Query: 116 LWKAHKKLTRSAL-------------LLG-IRDSMEPVVEQLTQEFCER--MRAQPGTPV 159
WK ++ S + L G + +V L + + + +P T V
Sbjct: 140 HWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSADGAFLDPRPLTVV 199
Query: 160 AIEEEFSLLTCSIICYLTFGDKIKDDNLMPAYYKCI---QEVLKTWSHWSIQIVDVIPFL 216
A+ S +C FG + D+ P + + + +E +T S+ VDV+P+L
Sbjct: 200 AVAN-----VMSAVC---FGCRYSHDD--PEFRELLSHNEEFGRTVGAGSL--VDVMPWL 247
Query: 217 RFFPNPG---LRRLKQAIEKRDHIVEMQLRQHKESLVAGQW-RDMMDYMLQGVAQPSMEE 272
++FPNP R +Q + + + +H ESL G RDMMD + + + +
Sbjct: 248 QYFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAGD 307
Query: 273 --GSGQLLEGHVHMAAVDLLIGGTETTANT-LSWAVVFLLHHPEIQQRLQEELDHELGPG 329
G G L+ A + + G ++ T +T L W ++ +P++Q R+Q ELD +G
Sbjct: 308 SHGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVG-- 365
Query: 330 ASSSRVPYK-DRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPN 388
R+P D+ LP + A + E +R VP+ +PH TT +S+ GY IP+ TV+ N
Sbjct: 366 --RDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVN 423
Query: 389 LQGAHLDETVWERPHEFWPDRFLE------PGKNSRALAFGCGARVCLGEPLARLELFVV 442
+ D W P F P RFL+ SR + F G R C+GE L++++LF+
Sbjct: 424 QWSVNHDPLKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLF 483
Query: 443 LTRL 446
++ L
Sbjct: 484 ISIL 487
>gi|13699809 cytochrome P450, family 2, subfamily A, polypeptide 13
[Homo sapiens]
Length = 494
Score = 150 bits (379), Expect = 3e-36
Identities = 120/469 (25%), Positives = 220/469 (46%), Gaps = 28/469 (5%)
Query: 1 MLLLGLLL--LLPLLAGARLLWNWWKLRSLHLPPLAP-------GFLHLLQPDLPIYLLG 51
ML GLLL LL L L+ W + +S P P +L L + L+
Sbjct: 1 MLASGLLLVTLLACLTVMVLMSVWRQRKSRGKLPPGPTPLPFIGNYLQLNTEQMYNSLMK 60
Query: 52 LTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYP-DLSL 110
+++++GP++ +HLG + VVVL ++EA+V + +F+GR E T+ + + Y S
Sbjct: 61 ISERYGPVFTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSN 120
Query: 111 GDYSLLWKAHKKLTRSALLLGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTC 170
G+ + + T +G R E + E+ + +R G + S
Sbjct: 121 GERAKQLRRFSIATLRGFGVGKRGIEERIQEE-AGFLIDALRGTHGANIDPTFFLSRTVS 179
Query: 171 SIICYLTFGDKIKDDNLMPAYYKCIQEVLKTWSHWSI---QIVDVIP-FLRFFPNPGLRR 226
++I + FGD+ ++ + ++ +L ++ + Q+ ++ ++ P P +
Sbjct: 180 NVISSIVFGDRFDYED--KEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQA 237
Query: 227 LKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAA 286
K+ D I + ++ ++ +L RD +D L + + + L+ V M
Sbjct: 238 FKELQGLEDFIAK-KVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLV-MTT 295
Query: 287 VDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVP-YKDRARLPL 345
++L GTET + TL + + L+ HPE++ ++ EE+D +G +R P ++DRA++P
Sbjct: 296 LNLFFAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIG----KNRQPKFEDRAKMPY 351
Query: 346 LNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEF 405
A I E+ R ++P+ L HR + + + +P+GT + P L D + P +F
Sbjct: 352 TEAVIHEIQRFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDF 411
Query: 406 WPDRFLEP----GKNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAF 450
P FL+ K+ + F G R C GE LAR+ELF+ T ++Q F
Sbjct: 412 NPQHFLDKKGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNF 460
>gi|15147330 cytochrome P450, family 2, subfamily A, polypeptide 7
isoform 1 [Homo sapiens]
Length = 494
Score = 149 bits (376), Expect = 6e-36
Identities = 122/478 (25%), Positives = 228/478 (47%), Gaps = 36/478 (7%)
Query: 1 MLLLGLLL--LLPLLAGARLLWNWWKLRSLHLPPLAP-------GFLHLLQPDLPIYLLG 51
ML GLLL LL L L+ W + +S P P +L L + ++
Sbjct: 1 MLASGLLLVALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMK 60
Query: 52 LTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYP-DLSL 110
++ +GP++ +HLG + VVVL + EA+V + +F+GR E T+ V + Y S
Sbjct: 61 FSECYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVAFSN 120
Query: 111 GDYSLLWKAHKKLTRSALLLGIRD------SMEPVVEQLTQEFCERMRAQPGTPVAIEEE 164
G+ + K+L R A+ +RD +E +++ + E +R+ G +
Sbjct: 121 GERA------KQLLRFAIAT-LRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFF 173
Query: 165 FSLLTCSIICYLTFGDKIK-DDNLMPAYYKCIQEVLKTWSHWSIQIVDVIP-FLRFFPNP 222
S ++I + FGD+ +D + + + + S + Q+ ++ ++ P P
Sbjct: 174 LSRTVSNVISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGP 233
Query: 223 GLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHV 282
+ K ++ + + ++ ++ +L +D +D L + + + L+ ++
Sbjct: 234 QQQAFK-LLQGLEDFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLK-NL 291
Query: 283 HMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVP-YKDRA 341
M+ ++L I GTET + TL + + L+ HPE++ ++ EE+D +G +R P ++DR
Sbjct: 292 MMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIG----KNRQPKFEDRT 347
Query: 342 RLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWER 401
++P + A I E+ R V+P++L R + + + +P+GT + P L D + +
Sbjct: 348 KMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSN 407
Query: 402 PHEFWPDRFLEP----GKNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPS 455
P +F P FL+ K+ + F G R C GE LAR+ELF+ T ++Q F L S
Sbjct: 408 PQDFNPQHFLDDKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSS 465
>gi|193083148 cytochrome P450 family 2 subfamily C polypeptide 18
isoform 2 [Homo sapiens]
Length = 431
Score = 126 bits (317), Expect = 4e-29
Identities = 111/434 (25%), Positives = 187/434 (43%), Gaps = 84/434 (19%)
Query: 32 PLAPGFLHLLQPDLPIYLLGLTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAG 91
P+ L L D+ L ++ +GP++ ++ GL+ +VVL+ ++EA++ +F+G
Sbjct: 37 PIIGNILQLDVKDMSKSLTNFSKVYGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSG 96
Query: 92 RPE-PLTYKLVSRNYPDLSLGDYSLLWKAHKKLTRSALL------LGIRDSMEPVVEQLT 144
R P+ K+ + LG K K++ R L+ +G R S+E V++
Sbjct: 97 RGSFPVAEKV------NKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKR-SIEDRVQEEA 149
Query: 145 QEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKI--KDDNLMPAYYKCIQEVLKTW 202
+ E +R +P C++IC + F D+ KD + K +
Sbjct: 150 RCLVEELRKTNASPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEKFNEN----- 204
Query: 203 SHWSIQIVDVIPFLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYML 262
LR +P ++ EK + E + ESL+A
Sbjct: 205 -------------LRILSSPWIQ------EKHNQQSEFTV----ESLIA----------- 230
Query: 263 QGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEEL 322
D+ GTETT+ TL + ++ LL +PE+ ++QEE+
Sbjct: 231 ----------------------TVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEI 268
Query: 323 DHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEG 382
+ +G S +DR+ +P +A + E+ R ++P LPH T Y IP+G
Sbjct: 269 ECVVGRNRSPCM---QDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKG 325
Query: 383 TVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKNSRA----LAFGCGARVCLGEPLARLE 438
T II +L ++ + P F P FL+ N + + F G R+C+GE LAR+E
Sbjct: 326 TTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMGEGLARME 385
Query: 439 LFVVLTRLLQAFTL 452
LF+ LT +LQ F L
Sbjct: 386 LFLFLTTILQNFNL 399
>gi|15147328 cytochrome P450, family 2, subfamily A, polypeptide 7
isoform 2 [Homo sapiens]
Length = 443
Score = 116 bits (290), Expect = 5e-26
Identities = 81/327 (24%), Positives = 158/327 (48%), Gaps = 17/327 (5%)
Query: 140 VEQLTQE----FCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIK-DDNLMPAYYKC 194
+E+ QE E +R+ G + S ++I + FGD+ +D +
Sbjct: 94 IEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLSM 153
Query: 195 IQEVLKTWSHWSIQIVDVIP-FLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQ 253
+ + + S + Q+ ++ ++ P P + K ++ + + ++ ++ +L
Sbjct: 154 MLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFK-LLQGLEDFIAKKVEHNQRTLDPNS 212
Query: 254 WRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPE 313
+D +D L + + + L+ ++ M+ ++L I GTET + TL + + L+ HPE
Sbjct: 213 PQDFIDSFLIHMQEEEKNPNTEFYLK-NLMMSTLNLFIAGTETVSTTLRYGFLLLMKHPE 271
Query: 314 IQQRLQEELDHELGPGASSSRVP-YKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPS 372
++ ++ EE+D +G +R P ++DR ++P + A I E+ R V+P++L R + +
Sbjct: 272 VEAKVHEEIDRVIG----KNRQPKFEDRTKMPYMEAVIHEIQRFGDVIPMSLARRVKKDT 327
Query: 373 SISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEP----GKNSRALAFGCGARV 428
+ +P+GT + P L D + + P +F P FL+ K+ + F G R
Sbjct: 328 KFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKSDAFVPFSIGKRN 387
Query: 429 CLGEPLARLELFVVLTRLLQAFTLLPS 455
C GE LAR+ELF+ T ++Q F L S
Sbjct: 388 CFGEGLARMELFLFFTTVMQNFRLKSS 414
>gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide 43
isoform 2 [Homo sapiens]
Length = 503
Score = 113 bits (283), Expect = 3e-25
Identities = 110/448 (24%), Positives = 194/448 (43%), Gaps = 46/448 (10%)
Query: 48 YLLGL-------TQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKL 100
YL GL +K+G ++ L+ G Q ++V+ I+ +VK+ PL
Sbjct: 53 YLRGLWNFDRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMG 112
Query: 101 VSRNYPDLSLGDYSLLWKAHKKLTRSALLLGIRDSMEPVVEQLTQEFCERMR--AQPGTP 158
++ + + WK + L A M P++ Q +R A+
Sbjct: 113 FLKSALSFAEDEE---WKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKS 169
Query: 159 VAIEEEFSLLTCSIICYLTFGDKIKD-DNLMPAYYKCIQEVLKT-WSHWSIQIVDVIPFL 216
+ +++ F T +I FG + +N + K ++++LK + + ++ + PFL
Sbjct: 170 INLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFL 229
Query: 217 RFFPNPGLRRLKQAIEKRD--HIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGS 274
P L + +D H ++ + + KES + + + +D+ Q + + +E
Sbjct: 230 ----TPVFEALNIGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETK 285
Query: 275 GQLLEGHVHMAAVDLLI--GGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASS 332
+ + A ++I +TT+ TL + + L HP++QQ+LQEE+D L +
Sbjct: 286 SHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVL---PNK 342
Query: 333 SRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSS----ISGYDIPEGTVIIPN 388
+ V Y ++ L+ + E LRL PVV R TR I+G IP+G ++
Sbjct: 343 APVTYDALVQMEYLDMVVNETLRLFPVVS-----RVTRVCKKDIEINGVFIPKGLAVMVP 397
Query: 389 LQGAHLDETVWERPHEFWPDRFLEPGKNS----RALAFGCGARVCLGEPLARLELFVVLT 444
+ H D W P +F P+RF + K+S R + FG G R C+G A + + +
Sbjct: 398 IYALHHDPKYWTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVI 457
Query: 445 RLLQAFTLLPSG--------DALPSLQP 464
R LQ F+ P D LP LQP
Sbjct: 458 RALQNFSFKPCKETQIPLKLDNLPILQP 485
>gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide 43
isoform 1 [Homo sapiens]
Length = 504
Score = 108 bits (271), Expect = 9e-24
Identities = 107/445 (24%), Positives = 193/445 (43%), Gaps = 39/445 (8%)
Query: 48 YLLGL-------TQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKL 100
YL GL +K+G ++ L+ G Q ++V+ I+ +VK+ PL
Sbjct: 53 YLRGLWNFDRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMG 112
Query: 101 VSRNYPDLSLGDYSLLWKAHKKLTRSALLLGIRDSMEPVVEQLTQEFCERMR--AQPGTP 158
++ + + WK + L A M P++ Q +R A+
Sbjct: 113 FLKSALSFAEDEE---WKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKS 169
Query: 159 VAIEEEFSLLTCSIICYLTFGDKIKD-DNLMPAYYKCIQEVLKT-WSHWSIQIVDVIPFL 216
+ +++ F T +I FG + +N + K ++++LK + + ++ + PFL
Sbjct: 170 INLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFL 229
Query: 217 RFFPNPGLRRLKQAIEKRD--HIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGS 274
P L + +D H ++ + + KES + + + +D+ Q + + +E
Sbjct: 230 ----TPVFEALNIGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETK 285
Query: 275 GQLLEGHVHMAAVDLLI--GGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASS 332
+ + A ++I +TT+ TL + + L HP++QQ+LQEE+D L +
Sbjct: 286 SHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVL---PNK 342
Query: 333 SRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGA 392
+ V Y ++ L+ + E LRL PVV + + I+G IP+G ++ +
Sbjct: 343 APVTYDALVQMEYLDMVVNETLRLFPVVS-RVTRVCKKDIEINGVFIPKGLAVMVPIYAL 401
Query: 393 HLDETVWERPHEFWPD-RFLEPGKNS----RALAFGCGARVCLGEPLARLELFVVLTRLL 447
H D W P +F P+ RF + K+S R + FG G R C+G A + + + R L
Sbjct: 402 HHDPKYWTEPEKFCPESRFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRAL 461
Query: 448 QAFTLLPSG--------DALPSLQP 464
Q F+ P D LP LQP
Sbjct: 462 QNFSFKPCKETQIPLKLDNLPILQP 486
>gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide 4
[Homo sapiens]
Length = 503
Score = 107 bits (267), Expect = 2e-23
Identities = 103/413 (24%), Positives = 186/413 (45%), Gaps = 23/413 (5%)
Query: 54 QKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDLSLGDY 113
+K+G ++ + G Q V+ + I+ +VK+ P + V +S+ +
Sbjct: 66 KKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRP--FGPVGFMKSAISIAED 123
Query: 114 SLLWKAHKKLTRSALLLGIRDSMEPVVEQLTQEFCERMR--AQPGTPVAIEEEFSLLTCS 171
WK + L G M P++ Q +R A+ G PV +++ F +
Sbjct: 124 EE-WKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMD 182
Query: 172 IICYLTFGDKIKD-DNLMPAYYKCIQEVLK-TWSHWSIQIVDVIPFLRFFPNPGLRRLKQ 229
+I +FG I +N + + +++L+ + + V PFL P L L
Sbjct: 183 VITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLI----PILEVLNI 238
Query: 230 AIEKRD--HIVEMQLRQHKESLVAGQWRDMMDYM-LQGVAQPSMEEGSGQLLEGHVHMA- 285
+ R+ + + +++ KES + + +D++ L +Q S E S + L +A
Sbjct: 239 CVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQ 298
Query: 286 AVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPL 345
++ + G ETT++ LS+ + L HP++QQ+LQEE+D L A + Y ++
Sbjct: 299 SIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPT---YDTVLQMEY 355
Query: 346 LNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEF 405
L+ + E LRL P+ + L + I+G IP+G V++ H D W P +F
Sbjct: 356 LDMVVNETLRLFPIA-MRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKF 414
Query: 406 WPDRFLEPGKNS----RALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLP 454
P+RF + K++ FG G R C+G A + + + L R+LQ F+ P
Sbjct: 415 LPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKP 467
>gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5
[Homo sapiens]
Length = 502
Score = 102 bits (253), Expect = 1e-21
Identities = 86/348 (24%), Positives = 156/348 (44%), Gaps = 17/348 (4%)
Query: 117 WKAHKKLTRSALLLGIRDSMEPVVEQLTQEFCERMR--AQPGTPVAIEEEFSLLTCSIIC 174
WK + L G M P++ Q +R A+ G PV +++ F + +I
Sbjct: 126 WKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVIT 185
Query: 175 YLTFGDKIKD-DNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQAIEK 233
+FG I +N + + ++ LK + + +I F F P L ++
Sbjct: 186 GTSFGVNIDSLNNPQDPFVESTKKFLK-FGFLDPLFLSIILFP--FLTPVFEALNVSLFP 242
Query: 234 RDHI--VEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLI 291
+D I + + + K+S + + + +D++ + + +E + +AA ++
Sbjct: 243 KDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIF 302
Query: 292 --GGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNAT 349
G ETT++ LS+ + L HP++QQ+LQ+E+D L A + Y ++ L+
Sbjct: 303 IFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPT---YDAVVQMEYLDMV 359
Query: 350 IAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDR 409
+ E LRL PV + L + I+G IP+G++++ H D W P EF P+R
Sbjct: 360 VNETLRLFPVA-IRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPER 418
Query: 410 FLEPGKNSRA---LAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLP 454
F + + FG G R C+G A + + + L R+LQ F+ P
Sbjct: 419 FSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKP 466
>gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide 1
[Homo sapiens]
Length = 508
Score = 102 bits (253), Expect = 1e-21
Identities = 70/193 (36%), Positives = 97/193 (50%), Gaps = 9/193 (4%)
Query: 271 EEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGA 330
EE Q + G+V +LL+ G +T +NTLSWA+ L HPE+Q L E+ L PG
Sbjct: 300 EELPAQSILGNV----TELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPG- 354
Query: 331 SSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQ 390
SS+ ++LPLL A + EVLRL PVVP + + Y IP+ T++
Sbjct: 355 SSAYPSATVLSQLPLLKAVVKEVLRLYPVVP-GNSRVPDKDIHVGDYIIPKNTLVTLCHY 413
Query: 391 GAHLDETVWERPHEFWPDRFLEPGKNSR---ALAFGCGARVCLGEPLARLELFVVLTRLL 447
D + P+ F P R+L G +L FG G R C+G LA LEL + L ++L
Sbjct: 414 ATSRDPAQFPEPNSFRPARWLGEGPTPHPFASLPFGFGKRSCMGRRLAELELQMALAQIL 473
Query: 448 QAFTLLPSGDALP 460
F + P A P
Sbjct: 474 THFEVQPEPGAAP 486
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.140 0.436
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,844,907
Number of Sequences: 37866
Number of extensions: 986774
Number of successful extensions: 2458
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 68
Number of HSP's successfully gapped in prelim test: 11
Number of HSP's that attempted gapping in prelim test: 2195
Number of HSP's gapped (non-prelim): 99
length of query: 495
length of database: 18,247,518
effective HSP length: 106
effective length of query: 389
effective length of database: 14,233,722
effective search space: 5536917858
effective search space used: 5536917858
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.