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Search of human proteins with 14165274
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|14165274 golgi-associated microtubule-binding protein HOOK3
[Homo sapiens]
(718 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|14165274 golgi-associated microtubule-binding protein HOOK3 [... 1385 0.0
gi|7705415 hook homolog 1 [Homo sapiens] 790 0.0
gi|154354987 hook homolog 2 isoform 2 [Homo sapiens] 681 0.0
gi|154354985 hook homolog 2 isoform 1 [Homo sapiens] 676 0.0
gi|148762940 DVL-binding protein DAPLE [Homo sapiens] 174 3e-43
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 169 6e-42
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 169 6e-42
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 105 1e-22
gi|55770834 centromere protein F [Homo sapiens] 105 1e-22
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 105 2e-22
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 103 4e-22
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 103 6e-22
gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens] 103 7e-22
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 103 7e-22
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 102 1e-21
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 102 1e-21
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 102 1e-21
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 102 1e-21
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 102 1e-21
gi|31982906 cingulin-like 1 [Homo sapiens] 101 3e-21
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 100 4e-21
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap... 100 5e-21
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 100 6e-21
gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens] 99 1e-20
gi|36031016 CTCL tumor antigen L14-2 [Homo sapiens] 98 2e-20
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 97 4e-20
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 97 4e-20
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 97 4e-20
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 97 4e-20
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 97 4e-20
>gi|14165274 golgi-associated microtubule-binding protein HOOK3
[Homo sapiens]
Length = 718
Score = 1385 bits (3584), Expect = 0.0
Identities = 718/718 (100%), Positives = 718/718 (100%)
Query: 1 MFSVESLERAELCESLLTWIQTFNVDAPCQTVEDLTNGVVMAQVLQKIDPAYFDENWLNR 60
MFSVESLERAELCESLLTWIQTFNVDAPCQTVEDLTNGVVMAQVLQKIDPAYFDENWLNR
Sbjct: 1 MFSVESLERAELCESLLTWIQTFNVDAPCQTVEDLTNGVVMAQVLQKIDPAYFDENWLNR 60
Query: 61 IKTEVGDNWRLKISNLKKILKGILDYNHEILGQQINDFTLPDVNLIGEHSDAAELGRMLQ 120
IKTEVGDNWRLKISNLKKILKGILDYNHEILGQQINDFTLPDVNLIGEHSDAAELGRMLQ
Sbjct: 61 IKTEVGDNWRLKISNLKKILKGILDYNHEILGQQINDFTLPDVNLIGEHSDAAELGRMLQ 120
Query: 121 LILGCAVNCEQKQEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKK 180
LILGCAVNCEQKQEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKK
Sbjct: 121 LILGCAVNCEQKQEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKK 180
Query: 181 TTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSDSIEDPNSPA 240
TTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSDSIEDPNSPA
Sbjct: 181 TTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSDSIEDPNSPA 240
Query: 241 GRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEAQSLK 300
GRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEAQSLK
Sbjct: 241 GRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEAQSLK 300
Query: 301 DEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRK 360
DEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRK
Sbjct: 301 DEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRK 360
Query: 361 ANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRLRTERDSL 420
ANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRLRTERDSL
Sbjct: 361 ANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRLRTERDSL 420
Query: 421 KETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLN 480
KETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLN
Sbjct: 421 KETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLN 480
Query: 481 QEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAED 540
QEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAED
Sbjct: 481 QEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAED 540
Query: 541 SVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQM 600
SVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQM
Sbjct: 541 SVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQM 600
Query: 601 EERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQREM 660
EERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQREM
Sbjct: 601 EERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQREM 660
Query: 661 EEKYIVSAWYNMGMTLHKKAAEDRLASTGSGQSFLARQRQATSSRRSYPGHVQPATAR 718
EEKYIVSAWYNMGMTLHKKAAEDRLASTGSGQSFLARQRQATSSRRSYPGHVQPATAR
Sbjct: 661 EEKYIVSAWYNMGMTLHKKAAEDRLASTGSGQSFLARQRQATSSRRSYPGHVQPATAR 718
>gi|7705415 hook homolog 1 [Homo sapiens]
Length = 728
Score = 790 bits (2041), Expect = 0.0
Identities = 421/718 (58%), Positives = 539/718 (75%), Gaps = 19/718 (2%)
Query: 12 LCESLLTWIQTFNVDAPCQTVEDLTNGVVMAQVLQKIDPAYFDENWLNRIKTEVGDNWRL 71
LC+SL+ W+QTFN +PCQ V+ LT+GV MAQVL +ID A+F+E+WL+RIK +VGDNWR+
Sbjct: 14 LCDSLMIWLQTFNTASPCQDVKQLTSGVAMAQVLHQIDAAWFNESWLSRIKEDVGDNWRI 73
Query: 72 KISNLKKILKGILDYNHEILGQQINDFTLPDVNLIGEHSDAAELGRMLQLILGCAVNCEQ 131
K SN+KK+L+GI+ Y HE LGQQI++ +PD+N I E SD ELGR+LQLILGCA+NCE+
Sbjct: 74 KASNVKKVLQGIMSYYHEFLGQQISEALIPDLNQITECSDPVELGRLLQLILGCAINCEK 133
Query: 132 KQEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELNEALSA 191
KQE+IQ IM +EESVQHVVMTAIQELMSKE S NDA +L++QLK+ EEL EAL+
Sbjct: 134 KQEHIQNIMTLEESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQLKRALEELQEALAE 193
Query: 192 KEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSD-SIEDPNSPAGRRHLQLQTQ 250
KEE+ QRC ELDMQV LQ+EK+SL++EN+++ E+L+Q D S +DPN+ +++ Q Q
Sbjct: 194 KEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFDDPNTVVAKKYFHAQLQ 253
Query: 251 LEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEAQSLKDEIDVLRHSS 310
LEQLQEE FRLEAAKDDYR+ CEELEK++ E + +NDELT+LA+E ++LKDEIDVLR +S
Sbjct: 254 LEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELTSLAEETRALKDEIDVLRATS 313
Query: 311 DKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAARSQLET 370
DK +KLE VE Y++KL+DL DLR+QVK L+E N MYM NTVSLEEEL+KANAAR+QLET
Sbjct: 314 DKANKLESTVEIYRQKLQDLNDLRKQVKTLQETNMMYMHNTVSLEEELKKANAARTQLET 373
Query: 371 YKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRLRTERDSLKETIEELRCV 430
YKRQV +L +LS ESK+AD L FE KRL+EK ++L KEK+RL +RD+LKET EELRC
Sbjct: 374 YKRQVQDLHVKLSSESKRADTLAFEMKRLEEKHEALLKEKERLIEQRDTLKETNEELRCS 433
Query: 431 QAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSDNEKIA 490
Q Q+ L + +S ++LAAEI+ E RE IRLQHENKML+L QEGS+NE+I
Sbjct: 434 QVQQDHLNQ---TDASATKSYENLAAEIMPVEYREVFIRLQHENKMLRLQQEGSENERIE 490
Query: 491 LLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQGSKA--EDSVLLKKKL 548
LQ L+ + + NELETE RL +R+ E+Q Q+E+LQKSLQ+QGSK+ E S LK+KL
Sbjct: 491 ELQEQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQKSLQEQGSKSEGESSSKLKQKL 550
Query: 549 EEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKKYL 608
E H+EKL E + ELQKK+ +IEDL+P N + KI EL+ AL+KK+E+MK MEERYK YL
Sbjct: 551 EAHMEKLTEVHEELQKKQELIEDLQPDINQNVQKINELEAALQKKDEDMKAMEERYKMYL 610
Query: 609 EKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQREMEEKYIVSA 668
EKA++VI+TLDPK N +A EI L+ QL E++R LE E + K R+ EEK IVSA
Sbjct: 611 EKARNVIKTLDPKLNPASA-EIMLLRKQLAEKERRIEILESECKVAKF-RDYEEKLIVSA 668
Query: 669 WYNMGMTLHKKAAEDRLASTGS----------GQSFLARQRQATSSRRSYPGHVQPAT 716
WYN + K E RL S G +SFLA+QR T++RR+ V PAT
Sbjct: 669 WYNKSLAFQKLGMESRLVSGGGACSDTGACTPARSFLAQQRHITNTRRNLSVKV-PAT 725
>gi|154354987 hook homolog 2 isoform 2 [Homo sapiens]
Length = 717
Score = 681 bits (1756), Expect = 0.0
Identities = 359/716 (50%), Positives = 517/716 (72%), Gaps = 8/716 (1%)
Query: 6 SLERAELCESLLTWIQTFNVDAPCQTVEDLTNGVVMAQVLQKIDPAYFDENWLNRIKTEV 65
S+++AELC SLLTW+QTF+V +PC + +DL++G+ +A VL +IDP++F+E WL I +
Sbjct: 2 SVDKAELCGSLLTWLQTFHVPSPCASPQDLSSGLAVAYVLNQIDPSWFNEAWLQGISEDP 61
Query: 66 GDNWRLKISNLKKILKGILDYNHEILGQQINDFTLPDVNLIGEHSDAAELGRMLQLILGC 125
G NW+LK+SNLK +L+ +++Y+ ++L +++ LPDV+LIGE SD AELG++LQL+LGC
Sbjct: 62 GPNWKLKVSNLKMVLRSLVEYSQDVLAHPVSEEHLPDVSLIGEFSDPAELGKLLQLVLGC 121
Query: 126 AVNCEQKQEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEEL 185
A++CE+KQ++IQ IM +EESVQHVVM AIQELM+K++P S + Y + D Q ++ L
Sbjct: 122 AISCEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRR-YYFL 180
Query: 186 NEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSDSIEDPNSPAGRRHL 245
+E +E+ QRC +L+ Q+ L EEK SL EN L ER+ + + P A ++ L
Sbjct: 181 SEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTA-KKLL 239
Query: 246 QLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEAQSLKDEIDV 305
LQ+QLEQLQEE FRLE+ ++D R+RC ELE+E++EL+ +N LT+LA EAQ+LKDE+D
Sbjct: 240 LLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDE 299
Query: 306 LRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAAR 365
LR SS++ +LE + S +++L +L +LRRQV+ LEE+N + + T LE+ELR+A + R
Sbjct: 300 LRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLR 359
Query: 366 SQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRLRTERDSLKETIE 425
+QLE +RQV ELQ + EE+ KA+K FE + L+EK +S+ KEK+RL ERDSL+E E
Sbjct: 360 AQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANE 419
Query: 426 ELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSD 485
ELRC Q Q LT + D+LAAEI+ E+RE L+RLQ ENK L QE +D
Sbjct: 420 ELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRL-CRQEAAD 478
Query: 486 NEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLK 545
E+ LQ L+DAN ++ LET++RL Q+L E+++QVE+LQK+LQ+QG K EDS+LLK
Sbjct: 479 RERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDSILLK 538
Query: 546 KKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSL-KIEELQEALRKKEEEMKQMEERY 604
+KLEEHL+KLHEA+ ELQ+KR IE+LEP ++S+ +IEELQ L+KK+ +++ MEERY
Sbjct: 539 RKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERY 598
Query: 605 KKYLEKAKSVIRTLDPKQN--QGAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQREMEE 662
++Y++KA+ V++T++PKQ GA PE+ +L+ QL+ERD LE ++EK++SQRE EE
Sbjct: 599 RRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEE 658
Query: 663 KYIVSAWYNMGMTLHKKAAEDRLASTGSGQSFLARQRQATSSRRSYPGHVQPATAR 718
K ++SAWYNMGM L ++A E+R + QSFLA+QR AT+SRR G + R
Sbjct: 659 KLLISAWYNMGMALQQRAGEER--APAHAQSFLAQQRLATNSRRGPLGRLASLNLR 712
>gi|154354985 hook homolog 2 isoform 1 [Homo sapiens]
Length = 719
Score = 676 bits (1743), Expect = 0.0
Identities = 359/718 (50%), Positives = 517/718 (72%), Gaps = 10/718 (1%)
Query: 6 SLERAELCESLLTWIQTFNVDAPCQTVEDLTNGVVMAQVLQKIDPAYFDENWLNRIKTEV 65
S+++AELC SLLTW+QTF+V +PC + +DL++G+ +A VL +IDP++F+E WL I +
Sbjct: 2 SVDKAELCGSLLTWLQTFHVPSPCASPQDLSSGLAVAYVLNQIDPSWFNEAWLQGISEDP 61
Query: 66 GDNWRLKISNLKKILKGILDYNHEILGQQINDFTLPDVNLIGEHSDAAELGRMLQLILGC 125
G NW+LK+SNLK +L+ +++Y+ ++L +++ LPDV+LIGE SD AELG++LQL+LGC
Sbjct: 62 GPNWKLKVSNLKMVLRSLVEYSQDVLAHPVSEEHLPDVSLIGEFSDPAELGKLLQLVLGC 121
Query: 126 AVNCEQKQEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEEL 185
A++CE+KQ++IQ IM +EESVQHVVM AIQELM+K++P S + Y + D Q ++ L
Sbjct: 122 AISCEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRR-YYFL 180
Query: 186 NEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSDSIEDPNSPAGRRHL 245
+E +E+ QRC +L+ Q+ L EEK SL EN L ER+ + + P A ++ L
Sbjct: 181 SEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTA-KKLL 239
Query: 246 QLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEAQSLKDEIDV 305
LQ+QLEQLQEE FRLE+ ++D R+RC ELE+E++EL+ +N LT+LA EAQ+LKDE+D
Sbjct: 240 LLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDE 299
Query: 306 LRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAAR 365
LR SS++ +LE + S +++L +L +LRRQV+ LEE+N + + T LE+ELR+A + R
Sbjct: 300 LRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLR 359
Query: 366 SQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRLRTERDSLKETIE 425
+QLE +RQV ELQ + EE+ KA+K FE + L+EK +S+ KEK+RL ERDSL+E E
Sbjct: 360 AQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANE 419
Query: 426 ELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSD 485
ELRC Q Q LT + D+LAAEI+ E+RE L+RLQ ENK L QE +D
Sbjct: 420 ELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRL-CRQEAAD 478
Query: 486 NEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAED--SVL 543
E+ LQ L+DAN ++ LET++RL Q+L E+++QVE+LQK+LQ+QG K ED S+L
Sbjct: 479 RERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDAISIL 538
Query: 544 LKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSL-KIEELQEALRKKEEEMKQMEE 602
LK+KLEEHL+KLHEA+ ELQ+KR IE+LEP ++S+ +IEELQ L+KK+ +++ MEE
Sbjct: 539 LKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEE 598
Query: 603 RYKKYLEKAKSVIRTLDPKQN--QGAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQREM 660
RY++Y++KA+ V++T++PKQ GA PE+ +L+ QL+ERD LE ++EK++SQRE
Sbjct: 599 RYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQ 658
Query: 661 EEKYIVSAWYNMGMTLHKKAAEDRLASTGSGQSFLARQRQATSSRRSYPGHVQPATAR 718
EEK ++SAWYNMGM L ++A E+R + QSFLA+QR AT+SRR G + R
Sbjct: 659 EEKLLISAWYNMGMALQQRAGEER--APAHAQSFLAQQRLATNSRRGPLGRLASLNLR 714
>gi|148762940 DVL-binding protein DAPLE [Homo sapiens]
Length = 2028
Score = 174 bits (440), Expect = 3e-43
Identities = 169/690 (24%), Positives = 326/690 (47%), Gaps = 86/690 (12%)
Query: 3 SVESLERAELCESLLTWIQTFNVDAP-----CQTVEDLTNGVVMAQVLQKIDPAYFDENW 57
+V L L L+TW++TF DL +G+ + Q++ +IDP ++
Sbjct: 4 TVSELLELFLQSPLVTWVKTFGPFGSGSQDNLTMYMDLVDGIFLNQIMLQIDPRPTNQ-- 61
Query: 58 LNRIKTEVGDNWRLKISNLKKILKGILDYNHEILGQQINDFTLPDVNLIGEH----SDAA 113
RI V ++ L+I NL +++ I Y E+L QQ+ LP+V +IG
Sbjct: 62 --RINKHVNNDVNLRIQNLTILVRNIKTYYQEVL-QQLIVMNLPNVLMIGRDPLSGKSME 118
Query: 114 ELGRMLQLILGCAVNCEQKQEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVD 173
E+ ++L L+LGCAV CE+K+E+I+ I ++ Q ++ IQE+ + V + +++
Sbjct: 119 EIKKVLLLVLGCAVQCERKEEFIERIKQLDIETQAGIVAHIQEVTHNQENVF--DLQWLE 176
Query: 174 LDRQLKKTTEELNEA--LSAKEEIAQR--CHELDMQVAALQEEKSSLLAENQVLMERLNQ 229
L + E L+ + L + I QR C EL + L +E+ L A++ + +
Sbjct: 177 LPDVAPEELEALSRSMVLHLRRLIDQRDECTEL---IVDLTQERDYLQAQHPPSPIKSSS 233
Query: 230 SDSIEDPNSPAG---RRHLQLQ-----TQLEQLQEETFRLEAAKDDYRIRCEELEKEISE 281
+DS P S ++HL ++ +L ++++E D R ++L E+ +
Sbjct: 234 ADSTPSPTSSLSSEDKQHLAVELADTKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQK 293
Query: 282 LRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLE 341
++Q+N +L A A++ +DE+D LR +++V +LE ++ K+KL D+ + +++ L
Sbjct: 294 VKQENIQLAADARSARAYRDELDSLREKANRVERLELELTRCKEKLHDVDFYKARMEELR 353
Query: 342 EKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKE 401
E N + ++ LEE+L A A K +L+ E +LK
Sbjct: 354 EDNIILIETKAMLEEQLTAARA---------------------RGDKVHELEKENLQLKS 392
Query: 402 KVDSLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQG------LMPLGSQESSDSLA 455
K+ L+ ++D T++ ++E +EE ++ + Q + L L +
Sbjct: 393 KLHDLELDRD---TDKKRIEELLEENMVLEIAQKQSMNESAHLGWELEQLSKNADLSDAS 449
Query: 456 AEIVTPEIRE----KLIRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELETENR 511
+ E+ E ++++L+ EN+ L+ +G + + +L+++ L+ ELE EN
Sbjct: 450 RKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASL-----VLEESGLKCGELEKENH 504
Query: 512 LVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIED 571
+++++ ++Q+Q+E ++S QD + +E+ + K++L+ +E L K I+D
Sbjct: 505 QLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDMETLK------ADKARQIKD 558
Query: 572 LEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQ 631
LE + + L A+ E + E K +EK + + N G +++
Sbjct: 559 LEQ-------EKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEAN-GKLSQLE 610
Query: 632 ALKNQLQERDRLFHSLEKEYEKTKSQREME 661
K QL RD L + EK K +RE++
Sbjct: 611 FEKRQL-HRD-LEQAKEKGERAEKLERELQ 638
Score = 91.7 bits (226), Expect = 2e-18
Identities = 118/516 (22%), Positives = 230/516 (44%), Gaps = 53/516 (10%)
Query: 178 LKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQV----LMERLNQSDSI 233
L +T L E L+A + HEL+ + L+ + L + + E L ++ +
Sbjct: 359 LIETKAMLEEQLTAARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIEELLEENMVL 418
Query: 234 EDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEEL-EKEISELRQQNDELTTL 292
E + L +LEQL + +A++ + E I +L ++N L +
Sbjct: 419 EIAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQST 478
Query: 293 ADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTV 352
Q L+D VL S K +LE + KK+E L Q +L EK + T+
Sbjct: 479 I---QGLRDASLVLEESGLKCGELEKENHQLSKKIEKL-----QTQLEREKQSNQDLETL 530
Query: 353 SLEEELRKANAARSQLETYK----RQVVELQ----------------NRLSEESKKADKL 392
S EE +R+ +S +ET K RQ+ +L+ +++S E++ D +
Sbjct: 531 S-EELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKD-V 588
Query: 393 DFEYKRLKEKVDSLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSD 452
+ E K L + V + +L E+ L +E+ + + + + + L L QE +
Sbjct: 589 EKENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAK-EKGERAEKLERELQRL--QEENG 645
Query: 453 SLAAEIVTPEIR-EKLIRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELETENR 511
LA ++ + E EK+ L+HE++ L+L +N + L + +L+ LE +N+
Sbjct: 646 RLARKVTSLETATEKVEALEHESQGLQL-----ENRTLRKSLDTLQNVSLQLEGLERDNK 700
Query: 512 LVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIED 571
++ LE++ VE ++ + ++ L+++ EE L K + L KK E
Sbjct: 701 QLDAENLELRRLVETMRFTSTKLAQMERENQQLEREKEE-LRKNVDLLKALGKKS---ER 756
Query: 572 LEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDP-----KQNQGA 626
LE + + S + LQ++L + + +E + + +++ R L+ Q +GA
Sbjct: 757 LELSYQSVSAENLRLQQSLESSSHKTQTLESELGELEAERQALRRDLEALRLANAQLEGA 816
Query: 627 APEIQALKNQLQERDRLFHSLEKEYEKTKSQREMEE 662
+ +AL+ ++ + ++ LEKE ++ Q E+++
Sbjct: 817 EKDRKALEQEVAQLEKDKKLLEKEAKRLWQQVELKD 852
Score = 87.4 bits (215), Expect = 4e-17
Identities = 121/536 (22%), Positives = 237/536 (44%), Gaps = 88/536 (16%)
Query: 175 DRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSDSIE 234
D K ELNE S+ R +L+ + +LQ L + VL E + +E
Sbjct: 447 DASRKSFVFELNECASS------RILKLEKENQSLQSTIQGLRDASLVLEESGLKCGELE 500
Query: 235 DPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLAD 294
N ++ +LQTQLE+ ++ LE EEL +E +L Q+D T AD
Sbjct: 501 KENHQLSKKIEKLQTQLEREKQSNQDLETLS-------EELIREKEQL--QSDMETLKAD 551
Query: 295 EAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSL 354
+A+ +KD L D +++ + S +++ + + R +K +E++N +L
Sbjct: 552 KARQIKD----LEQEKDHLNRA---MWSLRERSQVSSEAR--MKDVEKENK-------AL 595
Query: 355 EEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLK-------------- 400
+ + +AN SQLE KRQ+ + E+ ++A+KL+ E +RL+
Sbjct: 596 HQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGRLARKVTSLE 655
Query: 401 ---EKVDSLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAE 457
EKV++L+ E L+ E +L+++++ L+ V Q +GL Q +++L
Sbjct: 656 TATEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQ-----LEGLERDNKQLDAENLELR 710
Query: 458 IVTPEIR---EKLIRLQHENKMLKLNQE------------GSDNEKIALLQSLLDDANLR 502
+ +R KL +++ EN+ L+ +E G +E++ L + NLR
Sbjct: 711 RLVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLR 770
Query: 503 -KNELET---ENRLVNQRLLEVQSQVEELQKSLQD---QGSKAEDSVLLKKKLEEHLEKL 555
+ LE+ + + + L E++++ + L++ L+ ++ E + +K LE+ + +L
Sbjct: 771 LQQSLESSSHKTQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQL 830
Query: 556 HEANNELQK-----------KRAIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQMEERY 604
+ L+K K A+++D + + + L + L + + +++E
Sbjct: 831 EKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELE 890
Query: 605 KKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQREM 660
K + K V T+ + ++ K + Q+ L +E EK RE+
Sbjct: 891 KDNRDLTKQV--TVHARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNREL 944
Score = 65.5 bits (158), Expect = 2e-10
Identities = 115/512 (22%), Positives = 208/512 (40%), Gaps = 44/512 (8%)
Query: 173 DLDRQLK---KTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQ 229
DL +Q+ +T L E L ++ +Q +L ++ L +E + ++L++ +
Sbjct: 895 DLTKQVTVHARTLTTLREDLVLEKLKSQ---QLSSELDKLSQELEKVGLNRELLLQE-DD 950
Query: 230 SDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDEL 289
S S GR L+T L +E+ LEA ++ +LE E+ L+++ + L
Sbjct: 951 SGSDTKYKILEGRNESALKTTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKKECETL 1010
Query: 290 TTLADEAQSLKDEIDVLRHSSDKVSKLEGQVES----YKKKLEDLGDLRRQVKLLEEKNT 345
E Q L++ +H + K + E+ +K+ +L ++ + LE N
Sbjct: 1011 RQNQGEGQHLQNS---FKHPAGKTAASHQGKEAWGPGHKEATMELLRVKDRAIELERNNA 1067
Query: 346 MYMQNTVSLEEELRKANAAR----SQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKE 401
L+E+L+ SQ+ T ++Q LQ + + KL E L
Sbjct: 1068 ALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLSS 1127
Query: 402 KVDSLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTP 461
+ +L + L+ + KET E +Q Q+ QLT L E +L E +
Sbjct: 1128 QSAALTAQYTLLQNHH-TAKET--ENESLQRQQEQLTAAYEALLQDHEHLGTL-HERQSA 1183
Query: 462 EIREKLIRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQ 521
E E LIR K L N E E L D RK ELE +++
Sbjct: 1184 EY-EALIRQHSCLKTLHRNLELEHKE----LGERHGDMLKRKAELEEREKVLT------- 1231
Query: 522 SQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSL 581
++ E LQ+ + ++ L+ +L+ H+ E ++ A ++L+ NN+ L
Sbjct: 1232 TEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQLKGEYEELHAHTKELKTSLNNAQL 1291
Query: 582 KIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLD--PKQNQGAAPEIQALKNQLQ- 638
++ Q + +E+ + M+ K + + R ++N +IQ L Q Q
Sbjct: 1292 ELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRLKGNLEEENHHLLSQIQLLSQQNQM 1351
Query: 639 ------ERDRLFHSLEKEY-EKTKSQREMEEK 663
E +H +K+Y +K + R +EK
Sbjct: 1352 LLEQNMENKEQYHEEQKQYIDKLNALRRHKEK 1383
Score = 51.6 bits (122), Expect = 3e-06
Identities = 63/291 (21%), Positives = 129/291 (44%), Gaps = 37/291 (12%)
Query: 173 DLDRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSS---LLAENQVLMERLNQ 229
+L+ + K+ E + L K E+ +R L + ALQ+E+ + + ENQ L L++
Sbjct: 1201 NLELEHKELGERHGDMLKRKAELEEREKVLTTEREALQQEQRTNALAMGENQRLRGELDR 1260
Query: 230 SDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDEL 289
+ + H QL+ + E+L T L+ + ++ ++ + EL++Q+
Sbjct: 1261 VNFL----------HHQLKGEYEELHAHTKELKTSLNNAQLELNRWQARFDELKEQH--- 1307
Query: 290 TTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYM- 348
Q++ + L + + +S+L+G +E E+ L Q++LL ++N M +
Sbjct: 1308 -------QTMDISLTKLDNHCELLSRLKGNLE------EENHHLLSQIQLLSQQNQMLLE 1354
Query: 349 QNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKAD---KLDFEYKRLKEKVDS 405
QN + E+ + +L +R +L+ ++ ++ K D K + K V
Sbjct: 1355 QNMENKEQYHEEQKQYIDKLNALRRHKEKLEEKIMDQYKFYDPPPKKKNHWIGAKALVKL 1414
Query: 406 LQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQ-ESSDSLA 455
++ +K+ R+ LK T++ + PL SQ E+ D+ A
Sbjct: 1415 IKPKKE---GSRERLKSTVDSPPWQLESSDPASPAASQPLRSQAENPDTPA 1462
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 169 bits (429), Expect = 6e-42
Identities = 170/732 (23%), Positives = 337/732 (46%), Gaps = 94/732 (12%)
Query: 16 LLTWIQTFNVDAPCQTVE-----DLTNGVVMAQVLQKIDPAYFDENWLNRIKTEVGDNWR 70
L+TW++TF A L +GV + QV+ +I+P + R+ +V ++
Sbjct: 18 LVTWVKTFGPLAAGNGTNLDEYVALVDGVFLNQVMLQINPKLESQ----RVNKKVNNDAS 73
Query: 71 LKISNLKKILKGILDYNHEILGQQINDFTLPDVNLIGEH----SDAAELGRMLQLILGCA 126
L++ NL +++ I Y E L QQ+ +LP+V +IG++ E+ ++L L+LGCA
Sbjct: 74 LRMHNLSILVRQIKFYYQETL-QQLIMMSLPNVLIIGKNPFSEQGTEEVKKLLLLLLGCA 132
Query: 127 VNCEQKQEYIQAIMMMEESVQHVVMTAIQELMSKESPV------SAGNDAYVDLDRQLKK 180
V C++K+E+I+ I ++ + V IQE+ + V + + D++ LK
Sbjct: 133 VQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKN 192
Query: 181 TTEELNEALSAKEEIAQRCHELDMQVAALQE-EKSSLLAENQVLMERLNQSDSIEDPNSP 239
L + ++E ++ EL + L +S A++ + +++S + +
Sbjct: 193 MALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVE 252
Query: 240 AGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEAQSL 299
+++ ++L+E+T +L K + E++E E+ L+Q+N L + A A+
Sbjct: 253 LADAKAKIRRLRQELEEKTEQLLDCKQEL----EQMEIELKRLQQENMNLLSDARSARMY 308
Query: 300 KDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELR 359
+DE+D LR + +V KLE +V YK++L D+ + +V+ L+E N + ++ LE++L
Sbjct: 309 RDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLE 368
Query: 360 KANAARSQLETYKRQVVELQNRLSE-------ESKKADKLDFEYKRLKEKVDSLQKEKDR 412
A +L +++ ++L+ +L + + KK ++L E L+ E
Sbjct: 369 GTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLH 428
Query: 413 LRTERDSLKETIEELRCVQAQEG----QLTTQGLMPLGSQESSDSLAAEIVTPEI----- 463
L E + + T E Q G +LT+ L+ L + S + E + +
Sbjct: 429 LGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEG 488
Query: 464 -REKLIRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKN------------------ 504
K+++++ EN+ L E +NE + QSL + NL K+
Sbjct: 489 NASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLREN 548
Query: 505 ------ELETENRLVNQ---------------RLLEVQSQVEELQKSLQDQGSKAE---- 539
LE EN +NQ R+ +++ + + L +S+++ SK
Sbjct: 549 SERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEF 608
Query: 540 DSVLLKKKLEEHLEK---LHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEE 596
+ +KK+LE + EK E NEL E L+ + N + E++ EAL ++ E
Sbjct: 609 EKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKI-EALEQENSE 667
Query: 597 MKQMEERYKKYLEKAKSV---IRTLDPKQNQGAAPEIQALKN--QLQERDRLFHSLEKEY 651
+++ + KK L+ K++ + +L+ + +Q ++ +N L+ L+ E
Sbjct: 668 LERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLEN 727
Query: 652 EKTKSQREMEEK 663
++ +S++E +K
Sbjct: 728 KELESEKEQLKK 739
Score = 96.7 bits (239), Expect = 7e-20
Identities = 128/567 (22%), Positives = 254/567 (44%), Gaps = 89/567 (15%)
Query: 142 MEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELNEALSAKEEIAQRCHE 201
+ + V+ + +QE S ++ + D + QL+KT E L E + +I ++ +E
Sbjct: 503 LSKKVEILENEIVQEKQSLQNCQNLSKDLMKE-KAQLEKTIETLRENSERQIKILEQENE 561
Query: 202 LDMQVAALQEEKSSLLAE---------NQVLMERLNQSDS----IE----------DPNS 238
Q + ++S + AE N++L E + ++ S IE +
Sbjct: 562 HLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYK 621
Query: 239 PAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEE---LEKEISELRQQNDELTTLADE 295
G R +L+ +L L++E L+ + +I CE+ LE+E SEL ++N +L D
Sbjct: 622 EKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDS 681
Query: 296 AQSLKDEIDVLRHSSDKVS----KLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNT 351
++L +++ L + ++ +L VES K + L+ + K LE + +
Sbjct: 682 FKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGL 741
Query: 352 VSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKD 411
EL KA+ +++ Q ++++N+ +L + +K+ L+ E
Sbjct: 742 -----ELLKASFKKTERLEVSYQGLDIENQ---------RLQKTLENSNKKIQQLESELQ 787
Query: 412 RLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQ 471
L E +L++ +EEL+ + QL ++ + SL E T ++ + +L+
Sbjct: 788 DLEMENQTLQKNLEELKISSKRLEQL----------EKENKSLEQE--TSQLEKDKKQLE 835
Query: 472 HENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRL---LEVQSQVEELQ 528
ENK L+ E D + L++ N++ LE EN+ +++ + E +++EL+
Sbjct: 836 KENKRLRQQAEIKD--------TTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELE 887
Query: 529 KSLQDQGSKA----EDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIE 584
K ++ +A + V L++ L K + NN+L+K + +LE N
Sbjct: 888 KENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEK---LTHELEKIGLNKE---- 940
Query: 585 ELQEALRKKEEEMKQMEERYKKYLEKAKSVI-RTLDPKQNQGAAPE--IQALKNQLQERD 641
R +E + RYK K +S + ++L+ K+ + AA E ++ N Q+
Sbjct: 941 ------RLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLR 994
Query: 642 RLFHSLEKEYEKTKSQREMEEKYIVSA 668
+ +++K YE K QR+ EE+ + S+
Sbjct: 995 QELKTVKKNYEALK-QRQDEERMVQSS 1020
Score = 88.2 bits (217), Expect = 2e-17
Identities = 114/554 (20%), Positives = 228/554 (41%), Gaps = 87/554 (15%)
Query: 177 QLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSDSIEDP 236
QL + EL + + + + + +L ++ L+ EK L ++L +++ +E
Sbjct: 698 QLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVS 757
Query: 237 NSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEA 296
+ +LQ LE ++ +LE+ D + + L+K + EL+ + L L E
Sbjct: 758 YQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKEN 817
Query: 297 QSLKDEIDVLRHSSDKVSK----LEGQVESYKKKLED----LGDLRRQVKLLEEKNTMYM 348
+SL+ E L ++ K L Q E LE+ +G+L ++ K L ++ +Y
Sbjct: 818 KSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYK 877
Query: 349 QNTVSLEE--------------ELRKANAARSQLETYKRQVVELQNRLSEESKKADKL-- 392
++ V L+E +++ R L + K + ++ N L + + + +K+
Sbjct: 878 ESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGL 937
Query: 393 -------------DFEYKRLKEKVDSLQKE----------------------KDRLRTER 417
D YK L+ K++S K+ +LR E
Sbjct: 938 NKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQEL 997
Query: 418 DSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPE---IREKLIRLQHEN 474
++K+ E L+ Q Q+ + Q P+ +++ ++ T E ++++LI ++ N
Sbjct: 998 KTVKKNYEALK--QRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNN 1055
Query: 475 KMLKLNQEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQK---SL 531
L+ EK AL L +LET+N + ++L +Q Q LQ+ +L
Sbjct: 1056 ATLQA-------EKQALKTQL--------KQLETQNNNLQAQILALQRQTVSLQEQNTTL 1100
Query: 532 QDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALR 591
Q Q +K + + L L N +L +++ +E+ ++ L ++L
Sbjct: 1101 QTQNAKLQ---VENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLI 1157
Query: 592 KKEEEMKQMEERYKKYLEKAKSVIRTLDP--KQNQGAAPEIQALKNQLQERDRLFHSLEK 649
K E+++ + ER E S TL K + +++ NQL ++ LEK
Sbjct: 1158 KDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEK 1217
Query: 650 EYEKTKSQREMEEK 663
+ + + +E K
Sbjct: 1218 MLKVEQEKMLLENK 1231
Score = 74.3 bits (181), Expect = 4e-13
Identities = 100/465 (21%), Positives = 198/465 (42%), Gaps = 44/465 (9%)
Query: 133 QEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELNEALSAK 192
Q+ Q + ++++ + + +E M + SP +G D +R+ ++TT EL L K
Sbjct: 991 QQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDN--KWERESQETTREL---LKVK 1045
Query: 193 EEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSDSIEDPNSPAGRRHLQLQTQLE 252
+ + + ++ ++L AE Q L +L Q +E N+ + L LQ Q
Sbjct: 1046 DRLIE-----------VERNNATLQAEKQALKTQLKQ---LETQNNNLQAQILALQRQTV 1091
Query: 253 QLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELT-----------TLADEAQSLKD 301
LQE+ L+ ++ L + + L QN +L ++ E + LK
Sbjct: 1092 SLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKS 1151
Query: 302 EIDVLRHSSDKVSKL-EGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRK 360
D L +K+ L E Q Y+ + G L+ K LE ++ LE+ +
Sbjct: 1152 LYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHR-------DLEDRYNQ 1204
Query: 361 ANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRLRTERDSL 420
+ QLE ++ + Q ++ E+K + + EYK+L + D L +L E + L
Sbjct: 1205 LLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVL 1264
Query: 421 KETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRL-QHENKMLKL 479
+ + L+ + +L L S+ +I + ++ + L Q + + +
Sbjct: 1265 QTDHKNLKSL-LNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEE 1323
Query: 480 NQEGSDNEKIALLQ--SLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQGSK 537
N+ D + +LQ +LL+ K+ E R +L E++ Q E+L++ + DQ
Sbjct: 1324 NRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKF 1383
Query: 538 AEDSVLLKKK--LEEHLEKLHEANNELQKKRAIIEDLEPRFNNSS 580
+ S ++ + + KL ++ ++ ++R L P ++SS
Sbjct: 1384 YDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSS 1428
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 169 bits (429), Expect = 6e-42
Identities = 170/732 (23%), Positives = 337/732 (46%), Gaps = 94/732 (12%)
Query: 16 LLTWIQTFNVDAPCQTVE-----DLTNGVVMAQVLQKIDPAYFDENWLNRIKTEVGDNWR 70
L+TW++TF A L +GV + QV+ +I+P + R+ +V ++
Sbjct: 18 LVTWVKTFGPLAAGNGTNLDEYVALVDGVFLNQVMLQINPKLESQ----RVNKKVNNDAS 73
Query: 71 LKISNLKKILKGILDYNHEILGQQINDFTLPDVNLIGEH----SDAAELGRMLQLILGCA 126
L++ NL +++ I Y E L QQ+ +LP+V +IG++ E+ ++L L+LGCA
Sbjct: 74 LRMHNLSILVRQIKFYYQETL-QQLIMMSLPNVLIIGKNPFSEQGTEEVKKLLLLLLGCA 132
Query: 127 VNCEQKQEYIQAIMMMEESVQHVVMTAIQELMSKESPV------SAGNDAYVDLDRQLKK 180
V C++K+E+I+ I ++ + V IQE+ + V + + D++ LK
Sbjct: 133 VQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKN 192
Query: 181 TTEELNEALSAKEEIAQRCHELDMQVAALQE-EKSSLLAENQVLMERLNQSDSIEDPNSP 239
L + ++E ++ EL + L +S A++ + +++S + +
Sbjct: 193 MALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVE 252
Query: 240 AGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEAQSL 299
+++ ++L+E+T +L K + E++E E+ L+Q+N L + A A+
Sbjct: 253 LADAKAKIRRLRQELEEKTEQLLDCKQEL----EQMEIELKRLQQENMNLLSDARSARMY 308
Query: 300 KDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELR 359
+DE+D LR + +V KLE +V YK++L D+ + +V+ L+E N + ++ LE++L
Sbjct: 309 RDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLE 368
Query: 360 KANAARSQLETYKRQVVELQNRLSE-------ESKKADKLDFEYKRLKEKVDSLQKEKDR 412
A +L +++ ++L+ +L + + KK ++L E L+ E
Sbjct: 369 GTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLH 428
Query: 413 LRTERDSLKETIEELRCVQAQEG----QLTTQGLMPLGSQESSDSLAAEIVTPEI----- 463
L E + + T E Q G +LT+ L+ L + S + E + +
Sbjct: 429 LGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEG 488
Query: 464 -REKLIRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKN------------------ 504
K+++++ EN+ L E +NE + QSL + NL K+
Sbjct: 489 NASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLREN 548
Query: 505 ------ELETENRLVNQ---------------RLLEVQSQVEELQKSLQDQGSKAE---- 539
LE EN +NQ R+ +++ + + L +S+++ SK
Sbjct: 549 SERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEF 608
Query: 540 DSVLLKKKLEEHLEK---LHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEE 596
+ +KK+LE + EK E NEL E L+ + N + E++ EAL ++ E
Sbjct: 609 EKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKI-EALEQENSE 667
Query: 597 MKQMEERYKKYLEKAKSV---IRTLDPKQNQGAAPEIQALKN--QLQERDRLFHSLEKEY 651
+++ + KK L+ K++ + +L+ + +Q ++ +N L+ L+ E
Sbjct: 668 LERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLEN 727
Query: 652 EKTKSQREMEEK 663
++ +S++E +K
Sbjct: 728 KELESEKEQLKK 739
Score = 97.4 bits (241), Expect = 4e-20
Identities = 130/567 (22%), Positives = 258/567 (45%), Gaps = 90/567 (15%)
Query: 142 MEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELNEALSAKEEIAQRCHE 201
+ + V+ + +QE S ++ + D + QL+KT E L E + +I ++ +E
Sbjct: 503 LSKKVEILENEIVQEKQSLQNCQNLSKDLMKE-KAQLEKTIETLRENSERQIKILEQENE 561
Query: 202 LDMQVAALQEEKSSLLAE---------NQVLMERLNQSDS----IE----------DPNS 238
Q + ++S + AE N++L E + ++ S IE +
Sbjct: 562 HLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYK 621
Query: 239 PAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEE---LEKEISELRQQNDELTTLADE 295
G R +L+ +L L++E L+ + +I CE+ LE+E SEL ++N +L D
Sbjct: 622 EKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDS 681
Query: 296 AQSLKDEIDVLRHSSDKVS----KLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNT 351
++L +++ L + ++ +L VES K + L+ + K LE + +
Sbjct: 682 FKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGL 741
Query: 352 VSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKD 411
EL KA+ +++ Q ++++N+ +L + +K+ L+ E
Sbjct: 742 -----ELLKASFKKTERLEVSYQGLDIENQ---------RLQKTLENSNKKIQQLESELQ 787
Query: 412 RLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQ 471
L E +L++ +EEL+ + QL ++ + SL E T ++ + +L+
Sbjct: 788 DLEMENQTLQKNLEELKISSKRLEQL----------EKENKSLEQE--TSQLEKDKKQLE 835
Query: 472 HENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRL---LEVQSQVEELQ 528
ENK L+ E D + L++ N++ LE EN+ +++ + E +++EL+
Sbjct: 836 KENKRLRQQAEIKD--------TTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELE 887
Query: 529 KSLQDQGSKA----EDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIE 584
K ++ +A + V L++ L K + NN+L+K + +LE KI
Sbjct: 888 KENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEK---LTHELE--------KIG 936
Query: 585 ELQEALRKKEEEMKQMEERYKKYLEKAKSVI-RTLDPKQNQGAAPE--IQALKNQLQERD 641
+E L E+ ++RYK K +S + ++L+ K+ + AA E ++ N Q+
Sbjct: 937 LNKERLLHDEQ---STDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLR 993
Query: 642 RLFHSLEKEYEKTKSQREMEEKYIVSA 668
+ +++K YE K QR+ EE+ + S+
Sbjct: 994 QELKTVKKNYEALK-QRQDEERMVQSS 1019
Score = 88.2 bits (217), Expect = 2e-17
Identities = 114/553 (20%), Positives = 228/553 (41%), Gaps = 86/553 (15%)
Query: 177 QLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSDSIEDP 236
QL + EL + + + + + +L ++ L+ EK L ++L +++ +E
Sbjct: 698 QLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVS 757
Query: 237 NSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEA 296
+ +LQ LE ++ +LE+ D + + L+K + EL+ + L L E
Sbjct: 758 YQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKEN 817
Query: 297 QSLKDEIDVLRHSSDKVSK----LEGQVESYKKKLED----LGDLRRQVKLLEEKNTMYM 348
+SL+ E L ++ K L Q E LE+ +G+L ++ K L ++ +Y
Sbjct: 818 KSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYK 877
Query: 349 QNTVSLEE--------------ELRKANAARSQLETYKRQVVELQNRLSEESKKADKL-- 392
++ V L+E +++ R L + K + ++ N L + + + +K+
Sbjct: 878 ESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGL 937
Query: 393 ------------DFEYKRLKEKVDSLQKE----------------------KDRLRTERD 418
D YK L+ K++S K+ +LR E
Sbjct: 938 NKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELK 997
Query: 419 SLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPE---IREKLIRLQHENK 475
++K+ E L+ Q Q+ + Q P+ +++ ++ T E ++++LI ++ N
Sbjct: 998 TVKKNYEALK--QRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNA 1055
Query: 476 MLKLNQEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQK---SLQ 532
L+ EK AL L +LET+N + ++L +Q Q LQ+ +LQ
Sbjct: 1056 TLQA-------EKQALKTQL--------KQLETQNNNLQAQILALQRQTVSLQEQNTTLQ 1100
Query: 533 DQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRK 592
Q +K + + L L N +L +++ +E+ ++ L ++L K
Sbjct: 1101 TQNAKLQ---VENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIK 1157
Query: 593 KEEEMKQMEERYKKYLEKAKSVIRTLDP--KQNQGAAPEIQALKNQLQERDRLFHSLEKE 650
E+++ + ER E S TL K + +++ NQL ++ LEK
Sbjct: 1158 DHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKM 1217
Query: 651 YEKTKSQREMEEK 663
+ + + +E K
Sbjct: 1218 LKVEQEKMLLENK 1230
Score = 76.6 bits (187), Expect = 7e-14
Identities = 118/589 (20%), Positives = 250/589 (42%), Gaps = 60/589 (10%)
Query: 133 QEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELNEALSAK 192
Q+ Q + ++++ + + +E M + SP +G D +R+ ++TT EL L K
Sbjct: 990 QQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDN--KWERESQETTREL---LKVK 1044
Query: 193 EEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSDSIEDPNSPAGRRHLQLQTQLE 252
+ + + ++ ++L AE Q L +L Q +E N+ + L LQ Q
Sbjct: 1045 DRLIE-----------VERNNATLQAEKQALKTQLKQ---LETQNNNLQAQILALQRQTV 1090
Query: 253 QLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELT-----------TLADEAQSLKD 301
LQE+ L+ ++ L + + L QN +L ++ E + LK
Sbjct: 1091 SLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKS 1150
Query: 302 EIDVLRHSSDKVSKL-EGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRK 360
D L +K+ L E Q Y+ + G L+ K LE ++ LE+ +
Sbjct: 1151 LYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHR-------DLEDRYNQ 1203
Query: 361 ANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRLRTERDSL 420
+ QLE ++ + Q ++ E+K + + EYK+L + D L +L E + L
Sbjct: 1204 LLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVL 1263
Query: 421 KETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRL-QHENKMLKL 479
+ + L+ + +L L S+ +I + ++ + L Q + + +
Sbjct: 1264 QTDHKNLKSL-LNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEE 1322
Query: 480 NQEGSDNEKIALLQ--SLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQGSK 537
N+ D + +LQ +LL+ K+ E R +L E++ Q E+L++ + DQ
Sbjct: 1323 NRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKF 1382
Query: 538 AEDSVLLKKK--LEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKEE 595
+ S ++ + + KL ++ ++ ++R L P ++SS + L+ +
Sbjct: 1383 YDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSS------EGFLQLPHQ 1436
Query: 596 EMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRLFHSLEKEYEKTK 655
+ + LE +++ K + A + L+N+ +++D+ ++ Y ++
Sbjct: 1437 DSQDSSSVGSNSLEDGQTL---GTKKSSMVALKRLPFLRNRPKDKDK----MKACYRRSM 1489
Query: 656 SQREMEEKYIVSAWYNMGMTLHKKAAEDRLASTGSGQSFLARQRQATSS 704
S ++ + +++ + G T + + +D STG + L +T++
Sbjct: 1490 SMNDLVQSMVLAGQWT-GSTENLEVPDD--ISTGKRRKELGAMAFSTTA 1535
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 105 bits (262), Expect = 1e-22
Identities = 139/609 (22%), Positives = 259/609 (42%), Gaps = 70/609 (11%)
Query: 130 EQKQEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYV---DLDRQLKKTTEELN 186
+Q ++I+ +ME+ + +E ++ N V DL+ +LKK +
Sbjct: 992 DQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQ 1051
Query: 187 EALSAKEEIAQRCHELDMQVAALQ----EEKSSLLAENQVLMERLNQSDSIEDPNSPAGR 242
E AK ++ +L Q+A LQ E K L + + L L + D + A +
Sbjct: 1052 ELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALK 1111
Query: 243 RHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEAQSLKDE 302
+LQ Q+ +LQE+ F E A R + E+ ++++SE EL L E L+D
Sbjct: 1112 VVRELQAQIAELQED-FESEKAS---RNKAEKQKRDLSE------ELEALKTE---LEDT 1158
Query: 303 IDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKAN 362
+D + +K E +V KK LE+ + + +++ + L E+L +A
Sbjct: 1159 LDTTAAQQELRTKREQEVAELKKALEE--ETKNHEAQIQDMRQRHATALEELSEQLEQAK 1216
Query: 363 AARSQLETYKR-----------QVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKD 411
++ LE K+ +V LQ +E K KLD + + L KV E D
Sbjct: 1217 RFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKV----SEGD 1272
Query: 412 RLRTE----RDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKL 467
RLR E L+ ++ + + + + + S ES E++ E R+KL
Sbjct: 1273 RLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKL 1332
Query: 468 IRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEEL 527
N ++ Q + EK +L + ++ RKN + +++L +QSQ+ +
Sbjct: 1333 ------NLSSRIRQ--LEEEKNSLQEQQEEEEEARKN--------LEKQVLALQSQLADT 1376
Query: 528 QKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQ 587
+K + D E KKKL + E L + L++K + LE N ++++L
Sbjct: 1377 KKKVDDDLGTIESLEEAKKKLLKDAEAL---SQRLEEKALAYDKLEKTKNRLQQELDDLT 1433
Query: 588 EALRKKEEEMKQMEERYKKY---LEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRLF 644
L + + +E++ KK+ L + KS+ ++++ A + L L
Sbjct: 1434 VDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALE 1493
Query: 645 HSLE--KEYEKTKSQREMEEKYIVSAWYNMGMTLH-----KKAAEDRLASTGSGQSFLAR 697
+LE +E+E+ Q + + ++S+ ++G +H K+A E ++ + L
Sbjct: 1494 EALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELED 1553
Query: 698 QRQATSSRR 706
+ QAT +
Sbjct: 1554 ELQATEDAK 1562
Score = 102 bits (254), Expect = 1e-21
Identities = 129/538 (23%), Positives = 236/538 (43%), Gaps = 53/538 (9%)
Query: 173 DLDRQLKKTTEELNEALSA-------KEEIAQRCHELDMQVAALQEE-KSSLLAENQVLM 224
+L QL K EEL AL+ K + EL Q+A LQE+ +S + N+
Sbjct: 1080 ELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEK 1139
Query: 225 ERLNQSDSIE------DPNSPAGRRHLQLQTQLEQ--------LQEETFRLEAAKDDYRI 270
++ + S+ +E + +L+T+ EQ L+EET EA D R
Sbjct: 1140 QKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQ 1199
Query: 271 R----CEELEKEISELRQQNDELTT----LADEAQSLKDEIDVLRH----SSDKVSKLEG 318
R EEL +++ + ++ L L + + L E+ VL+ S K KL+
Sbjct: 1200 RHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDA 1259
Query: 319 QVESYKKKLEDLGDLRRQVKLLEEKNTMYMQ-NTVS--LEEELRKANAARSQLETYKRQV 375
QV+ K+ + GD R +V+L E+ + + + + VS LEE +K + + Q+
Sbjct: 1260 QVQELHAKVSE-GD-RLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQL 1317
Query: 376 VELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRLRTERDSLKETIEELRCVQAQEG 435
+ Q L EE+++ L ++L+E+ +SLQ++++ R +L++ + L+ A
Sbjct: 1318 QDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTK 1377
Query: 436 QLTTQGLMPLGSQESSDSLA---AEIVTPEIREKLIRLQHENKMLKLNQEGSDNEKIALL 492
+ L + S E + AE ++ + EK + K Q+ D+ + L
Sbjct: 1378 KKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLD 1437
Query: 493 QSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHL 552
+NL K + + + L ++ + + EE ++ + K ++ L + LEE L
Sbjct: 1438 HQRQVASNLEKKQKKFDQLLAEEKSISAR-YAEERDRAEAEAREKETKALSLARALEEAL 1496
Query: 553 EKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQE---ALRKKEEEMKQMEERYKKYLE 609
E E + ++ RA +EDL ++ + EL++ AL ++ EEM+ E + L+
Sbjct: 1497 EAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQ 1556
Query: 610 KAKSVIRTLDPKQNQGAAP---EIQALKNQLQERDRLF----HSLEKEYEKTKSQREM 660
+ L+ A ++Q Q +E+ RL LE E E + QR +
Sbjct: 1557 ATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRAL 1614
Score = 93.2 bits (230), Expect = 8e-19
Identities = 122/542 (22%), Positives = 237/542 (43%), Gaps = 67/542 (12%)
Query: 155 QELMSKESPVSAGNDAYVDLDRQLKKTTEELN---EALSAKEEIAQRCHELDMQVAALQE 211
+EL+ + + +++R+ ++ EE N E L A+ E+ E+ ++AA ++
Sbjct: 859 EELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQ 918
Query: 212 EKSSLLAENQVLMERLNQSDSIEDPNSPAGRRHLQ-LQTQLEQLQEETFRLEAAKDDYRI 270
E +L + + +E + + I + H+Q L+ QL++ + +L+ K
Sbjct: 919 ELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEA 978
Query: 271 RCEELEKEISELRQQNDEL---------------TTLADEAQSLKD----------EIDV 305
+ +++E+EI L QN + + LA+E + K+ I
Sbjct: 979 KIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISD 1038
Query: 306 LRHSSDKVSKLEGQVESYKKKLE-DLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAA 364
L K K ++E K+KL+ + DL+ Q+ L+ + EEEL+ A A
Sbjct: 1039 LEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALAR 1098
Query: 365 RSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRLRTERDSLKETI 424
+K +++ L + + + DFE + K + +K+K L E ++LK +
Sbjct: 1099 GDDETLHKNNALKVVRELQAQIAELQE-DFESE--KASRNKAEKQKRDLSEELEALKTEL 1155
Query: 425 EELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGS 484
E+ A + +L T+ + E +L E E + + +R +H + +L+++
Sbjct: 1156 EDTLDTTAAQQELRTKREQEVA--ELKKALEEETKNHEAQIQDMRQRHATALEELSEQ-- 1211
Query: 485 DNEKIALLQSLLDDANLRKNE--LETEN-------RLVNQRLLEVQSQVEELQKSLQDQG 535
L Q+ ANL KN+ LET+N +++ Q E + + ++L +Q+
Sbjct: 1212 ------LEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELH 1265
Query: 536 SKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKEE 595
+K + L+ +L E KL NEL ++E+ E + + L+ L + +
Sbjct: 1266 AKVSEGDRLRVELAEKASKL---QNELDNVSTLLEEAEKKGIKFAKDAASLESQL-QDTQ 1321
Query: 596 EMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRLFHSLEKEYEKTK 655
E+ Q E R K L S IR L+ ++N +L+ Q +E + +LEK+ +
Sbjct: 1322 ELLQEETRQKLNL---SSRIRQLEEEKN--------SLQEQQEEEEEARKNLEKQVLALQ 1370
Query: 656 SQ 657
SQ
Sbjct: 1371 SQ 1372
Score = 93.2 bits (230), Expect = 8e-19
Identities = 112/536 (20%), Positives = 240/536 (44%), Gaps = 101/536 (18%)
Query: 168 NDAYVDLDRQ------LKKTTEELNEALSAKEEIAQR-CHELDMQVAALQEEKSSLLAEN 220
+D VDLD Q L+K ++ ++ L+ ++ I+ R E D A +E+++ L+
Sbjct: 1430 DDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLA 1489
Query: 221 QVLMERLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEIS 280
+ L E L + E R++ QL+ +E L ++KDD ELEK
Sbjct: 1490 RALEEALEAKEEFE-------RQNKQLRADMEDLM-------SSKDDVGKNVHELEKSKR 1535
Query: 281 ELRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLL 340
L QQ +E+ T +E + D L+ + D +LE +++ K + E DL+ + +
Sbjct: 1536 ALEQQVEEMRTQLEELE------DELQATEDAKLRLEVNMQAMKAQFER--DLQTRDEQN 1587
Query: 341 EEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVV----ELQNRLSEESKKADKLDFEY 396
EEK + ++ LE EL R+ K+++ +L+ ++ +K D++ +
Sbjct: 1588 EEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQL 1647
Query: 397 KRLKEKVDSLQKEKDRLRTERDSL----KETIEELRCVQAQ----EGQLTTQGLMPLGSQ 448
++L+ ++ Q+E + R RD + KE+ ++L+ ++A+ + +L + ++
Sbjct: 1648 RKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAE 1707
Query: 449 ESSDSLAAEIVTP------------EIREKLIRLQHENKMLKLNQE-------------G 483
+ D LA EI + ++ +L+ E + + N E
Sbjct: 1708 QERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVD 1767
Query: 484 SDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVE---------------ELQ 528
+ N ++A +S ++ + +LE +N+ + +L E++ V+ +L+
Sbjct: 1768 TLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLE 1827
Query: 529 KSLQDQGSKAEDSVLL----KKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIE 584
+ L+ + + + L +KKL+E +++ +R + + + ++ +++
Sbjct: 1828 EQLEQEAKERAAANKLVRRTEKKLKEIF-------MQVEDERRHADQYKEQMEKANARMK 1880
Query: 585 ELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLD--PKQNQGAAPEIQALKNQLQ 638
+L+ L + EEE + +K + R LD + N+G + E+ LKN+L+
Sbjct: 1881 QLKRQLEEAEEEATRANASRRK-------LQRELDDATEANEGLSREVSTLKNRLR 1929
Score = 92.4 bits (228), Expect = 1e-18
Identities = 105/497 (21%), Positives = 223/497 (44%), Gaps = 66/497 (13%)
Query: 175 DRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSDSIE 234
+ +L+ EEL + + ++ E++ + L EEK ++LAE
Sbjct: 851 EEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEK-NILAE--------------- 894
Query: 235 DPNSPAGRRHLQLQTQL-EQLQEETFRLEAAKDDYRIRCEELEKEISELRQQN----DEL 289
LQ +T+L + +E RL A K + +LE + E ++N +E
Sbjct: 895 ---------QLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEK 945
Query: 290 TTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQ 349
+ Q L++++D + K+ + E+ KK+E+ ++ LLE++N+ +++
Sbjct: 946 KKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEE------EILLLEDQNSKFIK 999
Query: 350 NTVSLEEELRKANAARSQLETYKRQVVELQNR-------LSEESKKADKLDFEYKRLKEK 402
+E+ + + ++ ++ E + + +++N+ L E KK +K E ++ K K
Sbjct: 1000 EKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRK 1059
Query: 403 VDSLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPE 462
+D E L+ + L+ I+EL+ +Q + + QG + G E+ A V E
Sbjct: 1060 LDG---ETTDLQDQIAELQAQIDELK-LQLAKKEEELQGALARGDDETLHKNNALKVVRE 1115
Query: 463 IREKLIRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELE-TENRLVNQRLLEV- 520
++ ++ LQ + + K ++ ++ +K + L ++ K ELE T + Q+ L
Sbjct: 1116 LQAQIAELQEDFESEKASRNKAEKQK----RDLSEELEALKTELEDTLDTTAAQQELRTK 1171
Query: 521 -QSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNS 579
+ +V EL+K+L+++ E + + + H L E + +L++ + +LE N
Sbjct: 1172 REQEVAELKKALEEETKNHEAQI--QDMRQRHATALEELSEQLEQAKRFKANLEK--NKQ 1227
Query: 580 SLKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQG------AAPEIQAL 633
L+ + + A K + + E +K+ +K + ++ L K ++G A + L
Sbjct: 1228 GLETDNKELACEVKVLQQVKAESEHKR--KKLDAQVQELHAKVSEGDRLRVELAEKASKL 1285
Query: 634 KNQLQERDRLFHSLEKE 650
+N+L L EK+
Sbjct: 1286 QNELDNVSTLLEEAEKK 1302
Score = 88.2 bits (217), Expect = 2e-17
Identities = 135/668 (20%), Positives = 288/668 (43%), Gaps = 88/668 (13%)
Query: 72 KISNLKKILKGILDYNHEILGQQINDFTLPDVNLIGEHSDAAELGRMLQLIL-------- 123
+++ LKK L+ NHE QI D + E S+ E + + L
Sbjct: 1175 EVAELKKALEEETK-NHEA---QIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLE 1230
Query: 124 --GCAVNCEQKQEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKT 181
+ CE K +Q + E + + +QEL +K VS G+ V+L + K
Sbjct: 1231 TDNKELACEVK--VLQQVKAESEHKRKKLDAQVQELHAK---VSEGDRLRVELAEKASKL 1285
Query: 182 TEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSDSIEDPNSPAG 241
EL+ + EE ++ + A+L+ + L + Q L++
Sbjct: 1286 QNELDNVSTLLEEAEKKGIKFAKDAASLESQ----LQDTQELLQEET------------- 1328
Query: 242 RRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQ--------NDELTT-- 291
R+ L L +++ QL+EE L+ +++ + LEK++ L+ Q +D+L T
Sbjct: 1329 RQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIE 1388
Query: 292 --------LADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLE-DLGDLRRQVKLLEE 342
L +A++L ++ + DK+ K + +++ L DL R+ LE+
Sbjct: 1389 SLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEK 1448
Query: 343 KNTMYMQ-----NTVSLE--EELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFE 395
K + Q ++S EE +A A + ET + + L L E + ++ + +
Sbjct: 1449 KQKKFDQLLAEEKSISARYAEERDRAEAEAREKET---KALSLARALEEALEAKEEFERQ 1505
Query: 396 YKRLKEKVDSLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLA 455
K+L+ ++ L KD + L+++ R ++ Q ++ TQ +E D L
Sbjct: 1506 NKQLRADMEDLMSSKDDVGKNVHELEKS---KRALEQQVEEMRTQ------LEELEDELQ 1556
Query: 456 AEI---VTPEIREKLIRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELETENRL 512
A + E+ + ++ Q E + +++ + +++ + Q +A L + +
Sbjct: 1557 ATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAV 1616
Query: 513 VNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDL 572
+++ +E+ +++L+ ++ +KA D V+ K+L + ++ + EL++ RA +++
Sbjct: 1617 ASKKKMEID--LKDLEAQIE-AANKARDEVI--KQLRKLQAQMKDYQRELEEARASRDEI 1671
Query: 573 EPRFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQA 632
+ S K++ L+ + + +EE+ ER +++ E+ + + + +A A
Sbjct: 1672 FAQSKESEKKLKSLEAEILQLQEELAS-SERARRHAEQERDEL----ADEITNSASGKSA 1726
Query: 633 LKNQLQERDRLFHSLEKEYEKTKSQREMEEKYIVSAWYNMGMTLHKKAAEDRLASTGSGQ 692
L ++ + + LE+E E+ +S E+ + TL+ + A +R A+ S
Sbjct: 1727 LLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVD-TLNAELAAERSAAQKSDN 1785
Query: 693 SFLARQRQ 700
+ +RQ
Sbjct: 1786 ARQQLERQ 1793
Score = 80.9 bits (198), Expect = 4e-15
Identities = 107/482 (22%), Positives = 220/482 (45%), Gaps = 86/482 (17%)
Query: 245 LQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEI-SELRQQNDELTTLADEAQSLKDEI 303
LQ+ Q E+LQ AKD+ ++ +E + ++ EL + + L +E L +++
Sbjct: 845 LQVTRQEEELQ--------AKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQL 896
Query: 304 DVLRHSSDKVSKLEGQVESYKKKLED-LGDLRRQVKLLEEKNTMYMQNTVSLEEELRKAN 362
+ ++ ++ + K++LE+ L DL +V+ EE+N + L+ E +K
Sbjct: 897 QAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQI-------LQNEKKKMQ 949
Query: 363 AARSQLETYKRQVVELQNRLSEESKKADKLDFE-------YKRLKEKVDSLQKEKDRLRT 415
A + +L+ +L EE KL E K+++E++ L+ + +
Sbjct: 950 A----------HIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIK 999
Query: 416 ERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENK 475
E+ +++ I E A+E + + L + +++ + + +++ +E+ R + E
Sbjct: 1000 EKKLMEDRIAECSSQLAEEEE-KAKNLAKIRNKQ--EVMISDLEERLKKEEKTRQELEKA 1056
Query: 476 MLKLNQEGSD-NEKIALLQSLLDDANLR--KNELETENRLVN------------QRLLEV 520
KL+ E +D ++IA LQ+ +D+ L+ K E E + L + + E+
Sbjct: 1057 KRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVREL 1116
Query: 521 QSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLH----------EANNELQKKR---- 566
Q+Q+ ELQ+ + + + + K+ L E LE L A EL+ KR
Sbjct: 1117 QAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEV 1176
Query: 567 -AIIEDLEPRFNNSSLKIEELQE----ALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPK 621
+ + LE N +I+++++ AL + E+++Q +R+K LEK K + T
Sbjct: 1177 AELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQ-AKRFKANLEKNKQGLET---- 1231
Query: 622 QNQGAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQREMEEKYI-VSAWYNMGMTLHKKA 680
N+ A E++ L+ E E+++ K +++E + VS + + L +KA
Sbjct: 1232 DNKELACEVKVLQQV---------KAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKA 1282
Query: 681 AE 682
++
Sbjct: 1283 SK 1284
Score = 70.1 bits (170), Expect = 7e-12
Identities = 77/364 (21%), Positives = 165/364 (45%), Gaps = 52/364 (14%)
Query: 326 KLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEE 385
K++ L + RQ + L+ K+ + + ++E+ K ++E +Q++E +N L+E+
Sbjct: 840 KVKPLLQVTRQEEELQAKD----EELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQ 895
Query: 386 SKKADKLDFEYKRLKEKVDSLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPL 445
+ +L E + ++ ++ + ++E + + + +S E EE + E + + L
Sbjct: 896 LQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDL 955
Query: 446 GSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNE 505
Q + A + + +L ++ E K+ K+ +E LL+D N ++
Sbjct: 956 EEQLDEEEGARQ------KLQLEKVTAEAKIKKMEEE----------ILLLEDQN---SK 996
Query: 506 LETENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKK 565
E +L+ R+ E SQ+ E ++ ++ ++ LEE L+K + EL+K
Sbjct: 997 FIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKA 1056
Query: 566 RAIIE----DLEPRFNNSSLKIEELQEALRKKEEE------------------MKQMEER 603
+ ++ DL+ + +I+EL+ L KKEEE +K + E
Sbjct: 1057 KRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVREL 1116
Query: 604 YKKYLE-----KAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQR 658
+ E +++ R KQ + + E++ALK +L+ D L + ++ +TK ++
Sbjct: 1117 QAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELE--DTLDTTAAQQELRTKREQ 1174
Query: 659 EMEE 662
E+ E
Sbjct: 1175 EVAE 1178
Score = 67.4 bits (163), Expect = 4e-11
Identities = 78/313 (24%), Positives = 147/313 (46%), Gaps = 53/313 (16%)
Query: 156 ELMSKESPVSAGNDAYVDLDRQLKKTT-------EELNEALSAKEEIAQRCHE------- 201
+L E+ + A N A ++ +QL+K EL EA ++++EI + E
Sbjct: 1625 DLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKS 1684
Query: 202 LDMQVAALQEE-KSSLLAENQVLMERLNQSDSIEDPNSPAGRRHL-----QLQTQL---- 251
L+ ++ LQEE SS A ER +D I NS +G+ L +L+ ++
Sbjct: 1685 LEAEILQLQEELASSERARRHAEQERDELADEIT--NSASGKSALLDEKRRLEARIAQLE 1742
Query: 252 EQLQEETFRLEAAKDDYR---IRCEELEKEIS--------------ELRQQNDELTTLAD 294
E+L+EE +E D +R ++ + L E++ +L +QN EL
Sbjct: 1743 EELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQ 1802
Query: 295 EAQ-SLKDEIDVLRHSSD-KVSKLEGQVESYKKKLEDLGDL-RRQVKLLEEKNTMYMQNT 351
E + ++K + + + K+ +LE Q+E K+ L RR K L+E ++MQ
Sbjct: 1803 ELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKE---IFMQ-- 1857
Query: 352 VSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKD 411
+E+E R A+ + Q+E ++ +L+ +L E ++A + + ++L+ ++D + +
Sbjct: 1858 --VEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANE 1915
Query: 412 RLRTERDSLKETI 424
L E +LK +
Sbjct: 1916 GLSREVSTLKNRL 1928
Score = 49.3 bits (116), Expect = 1e-05
Identities = 43/173 (24%), Positives = 81/173 (46%), Gaps = 13/173 (7%)
Query: 519 EVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNN 578
E+Q++ EEL K + Q + +++K ++ LE+ + +LQ + + + E
Sbjct: 853 ELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRAR 912
Query: 579 SSLKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQ 638
+ K +EL+E L E +++ EER + L+ K ++ IQ L+ QL
Sbjct: 913 LAAKKQELEEILHDLESRVEEEEER-NQILQNEKKKMQA-----------HIQDLEEQLD 960
Query: 639 ERDRLFHSLEKEYEKTKSQ-REMEEKYIVSAWYNMGMTLHKKAAEDRLASTGS 690
E + L+ E +++ ++MEE+ ++ N KK EDR+A S
Sbjct: 961 EEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSS 1013
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 105 bits (262), Expect = 1e-22
Identities = 142/611 (23%), Positives = 265/611 (43%), Gaps = 78/611 (12%)
Query: 130 EQKQEYIQAIMMMEESVQHV-VMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELNEA 188
E+KQ + + ++ES H ++ E + +E ++ N + L+ + K E
Sbjct: 2314 EKKQ--LCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVE---T 2368
Query: 189 LSAK-EEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQ----SDSIEDPNSPAGRR 243
L AK E + Q L++ V ++ EK +L E Q ER+++ + S E+ +
Sbjct: 2369 LKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQE 2428
Query: 244 HLQ-----------LQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTL 292
+Q LQTQL++L E L ++ + + + L ++ L + +L
Sbjct: 2429 KVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQG 2488
Query: 293 ADEA---------------QSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQV 337
DEA Q ++D L +++S+L+ Q++ ++ + L + +
Sbjct: 2489 LDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEH 2548
Query: 338 KLLEEKNTMYMQNTVSLEEELR----KANAARSQLETYKRQVVELQNRLSEESKKADKLD 393
+L +E+N TV LE++++ K + + LE + L+N L E K DK+
Sbjct: 2549 QLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENEL--ELTKMDKMS 2606
Query: 394 FEYK--RLKEKVDSLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESS 451
F K ++ K LQ+E + + L+E + + A E QL + + + S
Sbjct: 2607 FVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEI-----KSSK 2661
Query: 452 DSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELETENR 511
D L + +K + H++++ K EG E+IA Q L +A + L +
Sbjct: 2662 DQLKELTLENSELKKSLDCMHKDQVEK---EGKVREEIAEYQLRLHEAEKKHQALLLDTN 2718
Query: 512 LVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIED 571
Q +E+Q+ E+L + S+ + LLK EE NN L+ I+E+
Sbjct: 2719 --KQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEE-------LNNSLKATTQILEE 2769
Query: 572 LEPRFNNSSLKIEELQEALRKKEEEM-------KQMEERYKKYLEKAKSVIRTLDPKQNQ 624
L+ ++ + +L++ + + +M KQ+EE K+ L+K S ++ KQ
Sbjct: 2770 LKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEE-KEILQKELSQLQAAQEKQKT 2828
Query: 625 GAA--PEIQALKNQLQERDRLFHSLEKEYEKTKSQREMEEKYIVSAWYNMGMTLHKKAAE 682
G ++ L +++E L +LE EKTK E +KY + + K+ E
Sbjct: 2829 GTVMDTKVDELTTEIKE---LKETLE---EKTKEADEYLDKYCSLLISHEKLEKAKEMLE 2882
Query: 683 DRLASTGSGQS 693
++A S QS
Sbjct: 2883 TQVAHLCSQQS 2893
Score = 100 bits (250), Expect = 4e-21
Identities = 150/650 (23%), Positives = 284/650 (43%), Gaps = 75/650 (11%)
Query: 130 EQKQEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELNEAL 189
E+ +E Q + + H + A E+ K + + D+ LK T L E L
Sbjct: 1982 EKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSS---DVSELLKDKTH-LQEKL 2037
Query: 190 SAKEEIAQ-----RCHELDMQVAALQEEKSSLLAENQVLMERLNQSDSIEDPNSPAGRRH 244
+ E+ +Q +C EL+ Q+A L +EK L+ E++ L RL++SD + S A
Sbjct: 2038 QSLEKDSQALSLTKC-ELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAA 2096
Query: 245 L----QLQTQLEQLQEETFRLEAAKDDYRIRCEELEKE----ISELRQQNDELTTLADEA 296
L + +L QEE +L + R+R E EK+ +L+++ E +L D+
Sbjct: 2097 LVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKV 2156
Query: 297 QSLKDEIDVLRHSSDKV----SKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTV 352
++L+ E+ + + + V + +VE+ K ++E++ R +K+ E
Sbjct: 2157 ENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMA---RSLKVFELDLVTLRSEKE 2213
Query: 353 SLEEELRKANAARSQLE----TYKRQVVELQN---RLSEESKKA-DKLDFEYKRLKEKVD 404
+L +++++ S+L+ ++K + E + ++ EESK A + L + K L E V
Sbjct: 2214 NLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVA 2273
Query: 405 SLQKEKDRLRT----------ERDSLKETIEELRC-VQAQEGQLTTQGLMPLGSQESSDS 453
+L +++ ++ E L+ +IE+LR ++A E + S+ +D
Sbjct: 2274 ALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADL 2333
Query: 454 LAAEIVTPEIREKLIRLQHENKMLKLNQEGSDNEKI-----ALLQSL----LDDANLR-- 502
L + E ++ R E+ L+ + E + + QSL LD +R
Sbjct: 2334 LKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSE 2393
Query: 503 KNELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNEL 562
K L E + +R+ E++ + LQ+ K ++ V +K+K +E L EL
Sbjct: 2394 KENLTNELQKEQERISELEIINSSFENILQE---KEQEKVQMKEKSSTAMEMLQTQLKEL 2450
Query: 563 QKKRAII----EDLEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTL 618
++ A + E + + N S ++E L+ +K + ++ ++E Y+ SV +
Sbjct: 2451 NERVAALHNDQEACKAKEQNLSSQVECLE---LEKAQLLQGLDEAKNNYIVLQSSVNGLI 2507
Query: 619 ----DPKQN-QGAAPEIQALKNQLQERDRLFHSL---EKEYEKTKSQREMEEKYIVSAWY 670
D KQ + EI LKNQ+Q++++L L E E++ K Q V
Sbjct: 2508 QEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQ 2567
Query: 671 NMGMTLHKKAA-EDRLASTGSGQSFLARQRQATS-SRRSYPGHVQPATAR 718
+ + K A+ +D L S L + + T + S+ V TA+
Sbjct: 2568 KIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAK 2617
Score = 85.5 bits (210), Expect = 2e-16
Identities = 101/525 (19%), Positives = 240/525 (45%), Gaps = 63/525 (12%)
Query: 157 LMSKESPVSAGNDAYVDLDRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSL 216
L E + + + +L QL+K EL E KE++ +C + ++ A ++ S+
Sbjct: 301 LQGHEKEMKGQVNKFQELQLQLEKAKVELIE----KEKVLNKCRDELVRTTAQYDQASTK 356
Query: 217 LAENQVLMERLNQSDSIEDPNSPAGRRHLQ--LQTQLEQLQEETFRLEAAKDDYRIRCEE 274
+ +++L + S + N+ + R L+ ++ + ++ QEE R + + +
Sbjct: 357 YTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRS-------FQT 409
Query: 275 LEKEISELRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLR 334
L++E +++ + L E Q K+ +VL+ DK++ ++ Q+E+
Sbjct: 410 LDQECIQMKAR------LTQELQQAKNMHNVLQAELDKLTSVKQQLENN----------- 452
Query: 335 RQVKLLEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDF 394
LEE + + + K N R +E K++ L++ +++++ L+
Sbjct: 453 -----LEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEA 507
Query: 395 EYKRLKEKVDSLQKEKDRLRTERDSLKETIEELR-CVQAQEGQLTTQGL-MPLGSQESSD 452
E K +K+ ++ Q + ++ + S + + +L+ + QE LT + L + + E
Sbjct: 508 ELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQR 567
Query: 453 SLAAEIVTPEIREKLIRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNE---LETE 509
+ +++ + E+ + +LN + S EK + ++LL L+K E L+ E
Sbjct: 568 DCSQDLLK----------KREHHIEQLNDKLSKTEKES--KALLSALELKKKEYEELKEE 615
Query: 510 NRLV------NQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKK-KLEEHLEKLHEANNEL 562
L N++LL +Q+E +++LQ + + E + ++ K E+ E++ +
Sbjct: 616 KTLFSCWKSENEKLL---TQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDR 672
Query: 563 QKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQ 622
+ I +L ++ S+++E + A + +++ + +++++K +E L Q
Sbjct: 673 ENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTG-Q 731
Query: 623 NQGAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQREMEEKYIVS 667
+ ++Q L N++ ++DR + L EYE + + ++ +V+
Sbjct: 732 VEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVT 776
Score = 81.6 bits (200), Expect = 2e-15
Identities = 128/622 (20%), Positives = 262/622 (42%), Gaps = 112/622 (18%)
Query: 130 EQKQEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELNEAL 189
+ K E ++ + M E Q +V I + + ++ V ++ R LK +L
Sbjct: 2153 KDKVENLERELQMSEENQELV---ILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLR 2209
Query: 190 SAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSD-SIEDPNSPAGRRHLQLQ 248
S KE + ++ E Q++ L + LL+ + L+E Q++ I++ + A LQ
Sbjct: 2210 SEKENLTKQIQEKQGQLSELDK----LLSSFKSLLEEKEQAEIQIKEESKTAVE---MLQ 2262
Query: 249 TQLEQLQE------------------------ETFRLEAAKDDYRIRCEELEKE----IS 280
QL++L E E +L + + R R E EK+ +
Sbjct: 2263 NQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQ 2322
Query: 281 ELRQQNDELTTLADEAQSLKDEIDVLR----HSSDKVSKLEGQVESYKKKLEDLGDLRRQ 336
+L++ L ++L+ E+++ R H++ + +G+VE+ K K+E + R
Sbjct: 2323 QLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRG 2382
Query: 337 VKL------LEEKNTMYMQNTVSLEEE-LRKANAARSQLETYKRQVVELQNRLSEESKKA 389
++L E++N + N + E+E + + S E ++ + + ++ E+S A
Sbjct: 2383 LELDVVTIRSEKEN---LTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTA 2439
Query: 390 -DKLDFEYKRLKEKVDSLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGS- 447
+ L + K L E+V +L +++ + + +L +E C++ ++ QL QGL +
Sbjct: 2440 MEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVE---CLELEKAQLL-QGLDEAKNN 2495
Query: 448 ----QESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRK 503
Q S + L E+ + ++KL + E LK NQ + ++ L + + L K
Sbjct: 2496 YIVLQSSVNGLIQEV--EDGKQKLEKKDEEISRLK-NQIQDQEQLVSKLSQVEGEHQLWK 2552
Query: 504 N----------ELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLE 553
ELE + +++ + +Q +E LQ S ++ ++ E + + K E +
Sbjct: 2553 EQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVN 2612
Query: 554 KLHEANNELQ--------KKRAIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQM----- 600
K+ ELQ K + E+L N + +++ L E ++ ++++K++
Sbjct: 2613 KMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENS 2672
Query: 601 ---------------------EE--RYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQL 637
EE Y+ L +A+ + L N+ EIQ + +L
Sbjct: 2673 ELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKL 2732
Query: 638 QERDRLFHSLEKEYEKTKSQRE 659
++ S + E + KS +E
Sbjct: 2733 TSKEECLSSQKLEIDLLKSSKE 2754
Score = 80.9 bits (198), Expect = 4e-15
Identities = 105/484 (21%), Positives = 219/484 (45%), Gaps = 52/484 (10%)
Query: 200 HELDMQVAALQEEKSSLLAENQVLMERLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETF 259
H L ++V E LL V+ +R + +S+ + + L + L+++Q T
Sbjct: 1770 HNLQLRVKETSNENLRLL---HVIEDRDRKVESLLNE-----MKELDSKLHLQEVQLMT- 1820
Query: 260 RLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQ 319
++EA C ELEK + EL+++N +L+ + E+ + R + + + +
Sbjct: 1821 KIEA--------CIELEKIVGELKKENSDLSEKLEYFSCDHQEL-LQRVETSEGLNSDLE 1871
Query: 320 VESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQ 379
+ + K ED+GD +V N + + + +E EL + + ++ +E ++ +E
Sbjct: 1872 MHADKSSREDIGDNVAKV------NDSWKERFLDVENELSRIRSEKASIE-HEALYLEAD 1924
Query: 380 NRLSEESKKADKLDFEYKR-----LKEKVDSLQKEKDRLRTERDSLKETIEELRCVQAQE 434
+ + K + D E K+ L+E++ + E+++LR E D++ + L + +
Sbjct: 1925 LEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKM 1984
Query: 435 GQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLK--LNQEGSDNEKIALL 492
+ T + L S +S ++ E++EK LQ + + L + EK+ L
Sbjct: 1985 KEKTQE----LESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSL 2040
Query: 493 QSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQG------SKAEDSVLLKK 546
+ +L K ELE + +N+ + + E LQ L + SKA ++ L++K
Sbjct: 2041 EKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEK 2100
Query: 547 -----KLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQME 601
+L E++H+ ++K R IE E + + + K++E + +++++ +E
Sbjct: 2101 GEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLE 2160
Query: 602 ERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQREME 661
+ E + VI LD + ++ E++ LK Q++E R E + +S++E
Sbjct: 2161 RELQMSEENQELVI--LDAENSKA---EVETLKTQIEEMARSLKVFELDLVTLRSEKENL 2215
Query: 662 EKYI 665
K I
Sbjct: 2216 TKQI 2219
Score = 75.5 bits (184), Expect = 2e-13
Identities = 89/451 (19%), Positives = 201/451 (44%), Gaps = 58/451 (12%)
Query: 170 AYVDLDRQLKKTTEELNEALSAKEEIAQRCHELDMQVAA-LQEEKSSLLAENQVLMERLN 228
A L++++K+ +E E LS ++ Q + +Q+ A L +E + VL L+
Sbjct: 381 ARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELD 440
Query: 229 QSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDE 288
+ S++ QL+ LE+ +++ R E A +I+ EL + + E++++N+
Sbjct: 441 KLTSVKQ----------QLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNL 490
Query: 289 LTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYM 348
L + +++ + +V LE ++++ K+ L + ++K KNT
Sbjct: 491 LKSHSEQ-------------KAREVCHLEAELKNIKQCLNQSQNFAEEMK---AKNTSQE 534
Query: 349 QNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQK 408
L+E++ + + + LE K V +L+ + K + ++L +K+ +K
Sbjct: 535 TMLRDLQEKINQQENSLT-LEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEK 593
Query: 409 EKDRLRTERDSLKETIEELR-------CVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTP 461
E L + + K+ EEL+ C +++ +L TQ + ++L ++I
Sbjct: 594 ESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQ------MESEKENLQSKINHL 647
Query: 462 E--IREKLIRLQHENKMLKLNQEGSDNEKIAL--LQSLLDDANLRKNELETENRLVNQRL 517
E ++ + I+ N+ ++ + +N + + L ++LD ++ E+ET+ +
Sbjct: 648 ETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSV---EVETQKLAYMELQ 704
Query: 518 LEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFN 577
+ + ++ QK +++ K L ++E+ KL +NE+ K +DL +
Sbjct: 705 QKAEFSDQKHQKEIENMCLKTSQ---LTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEY- 760
Query: 578 NSSLKIEELQEALRKKEEEMKQMEERYKKYL 608
E L++ L+ K+ + E+ + L
Sbjct: 761 ------ESLRDLLKSKDASLVTNEDHQRSLL 785
Score = 67.8 bits (164), Expect = 3e-11
Identities = 130/630 (20%), Positives = 245/630 (38%), Gaps = 156/630 (24%)
Query: 137 QAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELNEALSAKEEIA 196
Q +M + ES++ EL KES V+ +Q++K +EL S E
Sbjct: 70 QRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQ 129
Query: 197 QRCHELDMQVAALQ--------------------------------EEKSSLLAENQVLM 224
Q D+ + EE+ L AE + L
Sbjct: 130 QAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQ 189
Query: 225 -ERLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEET-------FRLEAAKDDYRIRCEELE 276
++ +Q+ N RH + QE+T + + D+ E
Sbjct: 190 AKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGE 249
Query: 277 KEISELRQ-----QNDELTTLADEAQS------LKDEIDVLRHSSDKVS-KLEGQVESYK 324
+E++ R + D ++ D + S LK + LR+ +++ +L+G + K
Sbjct: 250 QEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMK 309
Query: 325 KKLEDLGDLRRQ-----VKLLEEKNTM-------------YMQNT---VSLEEELRK--- 360
++ +L+ Q V+L+E++ + Y Q + +LE++L+K
Sbjct: 310 GQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTE 369
Query: 361 --------ANAARSQLE-TYKRQVVELQNRLSEESKKADKLDFEYKRLKEKV-------- 403
A +AR LE K + E Q LS + + LD E ++K ++
Sbjct: 370 DLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAK 429
Query: 404 ---DSLQKEKDRLRTERDSLKETIEELR---CVQAQEGQLTTQGLMPLGSQESSDSLAAE 457
+ LQ E D+L + + L+ +EE + C Q Q A++
Sbjct: 430 NMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQ------------------ASQ 471
Query: 458 IVTPEIREKLIRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRL 517
I E+R + ++ EN +LK + E E LE E + + Q L
Sbjct: 472 IKENELRRSMEEMKKENNLLKSHSEQKAREVC---------------HLEAELKNIKQCL 516
Query: 518 LEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFN 577
+ Q+ EE++ Q + D L++K+ + E + L+K + + DLE + +
Sbjct: 517 NQSQNFAEEMKAKNTSQETMLRD---LQEKINQ-----QENSLTLEKLKLAVADLEKQRD 568
Query: 578 NSSLKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQL 637
S Q+ L+K+E ++Q+ ++ K +++K+++ L+ K+ + +L
Sbjct: 569 CS-------QDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKE---------YEEL 612
Query: 638 QERDRLFHSLEKEYEKTKSQREMEEKYIVS 667
+E LF + E EK +Q E E++ + S
Sbjct: 613 KEEKTLFSCWKSENEKLLTQMESEKENLQS 642
Score = 66.2 bits (160), Expect = 1e-10
Identities = 118/553 (21%), Positives = 230/553 (41%), Gaps = 99/553 (17%)
Query: 176 RQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEK----------SSLLAENQVLME 225
R L+K E + K+E QR +LD AALQ++K ++L ENQ LME
Sbjct: 15 RALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLME 74
Query: 226 RLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQ 285
+ + S +LQ + Q+ + +L + K +++EK EL++
Sbjct: 75 ICESLEKTKQKISH------ELQVKESQVNFQEGQLNSGK-------KQIEKLEQELKRC 121
Query: 286 NDELTTLADEAQSLKDEIDVLRHSSDKV-------------SKLEGQVESYKKKLEDLGD 332
EL AQS ++ ++ K+ SK E E Y K++E+
Sbjct: 122 KSELERSQQAAQSADVSLNPC-NTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKR 180
Query: 333 LRRQVKLLEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKAD-K 391
L +VK L+ K ++ + A S + +++++ + + LS S++ +
Sbjct: 181 LEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQE--KTPSHLSSNSQRTPIR 238
Query: 392 LDF--EYKRLKEKV----DSLQKEK-----------------DRLRTERDSLKETIEELR 428
DF Y +++V +LQ K D+L+ + L+ I EL
Sbjct: 239 RDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELE 298
Query: 429 C-VQAQE----GQLTTQGLMPLGSQESS-DSLAAEIVTPEIREKLIRL-----QHENKML 477
+Q E GQ+ + L +++ + + E V + R++L+R Q K
Sbjct: 299 LRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYT 358
Query: 478 KLNQEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQV-EELQKSLQDQGS 536
L Q+ L+ L +D + ++ E+ + Q++ E + + EEL + + +
Sbjct: 359 ALEQK---------LKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQT 409
Query: 537 KAEDSVLLKKKLEEHLEKLHEANN----ELQKKRAIIEDLE---PRFNNSSLKIEELQEA 589
++ + +K +L + L++ +N EL K ++ + LE F + E+ +A
Sbjct: 410 LDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQA 469
Query: 590 LRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRLFHSLEK 649
+ KE E+++ E KK KS ++ A E+ L+ +L+ + + +
Sbjct: 470 SQIKENELRRSMEEMKKENNLLKS--------HSEQKAREVCHLEAELKNIKQCLNQSQN 521
Query: 650 EYEKTKSQREMEE 662
E+ K++ +E
Sbjct: 522 FAEEMKAKNTSQE 534
Score = 65.9 bits (159), Expect = 1e-10
Identities = 94/476 (19%), Positives = 207/476 (43%), Gaps = 58/476 (12%)
Query: 178 LKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSDSIEDPN 237
L+ + L +L +++++ +L Q L + K + EN + E+++QS E
Sbjct: 828 LQNRVDSLEFSLESQKQMNS---DLQKQCEELVQIKGEI-EENLMKAEQMHQSFVAETSQ 883
Query: 238 SPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEAQ 297
++ +LQE+T A ++ LE + EL+ ND++ T E Q
Sbjct: 884 ------------RISKLQEDT---SAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQ 928
Query: 298 SLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDL-RRQVKLLEEKNTMYMQNTVSLEE 356
LK +L S ++ L + KK++ + L +R+++ L ++N + SL +
Sbjct: 929 ELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQ 988
Query: 357 E----LRKANAARSQLETYKRQVVELQNRLSEES----KKADKLDFEYKRLKEKVDSLQK 408
E ++K+ + + ++ ++ + EL ++ +E ++ ++ Y+ L +K + Q+
Sbjct: 989 EKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQE 1048
Query: 409 EKDRLR---TERDSL----KETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTP 461
+ +L E SL K +E+L+ A+E Q ++
Sbjct: 1049 KNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQ----------------EFLTKLAFA 1092
Query: 462 EIREKLIRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQ 521
E R + + L+ E L E +DN+ + +A K E+ T N+ EV
Sbjct: 1093 EERNQNLMLELETVQQALRSEMTDNQ-----NNSKSEAGGLKQEIMTLKEEQNKMQKEVN 1147
Query: 522 SQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQ-KKRAIIEDLEPRFNNSS 580
++E ++ ++ +K E L + + +++ N+ K + +E E ++ +
Sbjct: 1148 DLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYN 1207
Query: 581 LKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQG-AAPEIQALKN 635
++ +L+ LR KE ++++ E+ + + +++ L+ Q + EI LK+
Sbjct: 1208 AQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKD 1263
Score = 62.4 bits (150), Expect = 1e-09
Identities = 106/452 (23%), Positives = 183/452 (40%), Gaps = 56/452 (12%)
Query: 174 LDRQLKKTTEELNEALSAKEEIAQRCHE-------LDMQVAALQEEKSS---LLAENQVL 223
+D + K +E ++ K + QRC E L + A QE+ S LL E L
Sbjct: 1004 IDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSL 1063
Query: 224 MERLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELR 283
E N+ + +E + H + T+L +E L ELE LR
Sbjct: 1064 CE--NRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLML----------ELETVQQALR 1111
Query: 284 -QQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEE 342
+ D EA LK EI L+ +K+ K +V ++ E L +K+++
Sbjct: 1112 SEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQK---EVNDLLQENEQL------MKVMKT 1162
Query: 343 KNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFE-YKRLKE 401
K+ + + +++ + R+Q +K Q+ +S +S A + E R KE
Sbjct: 1163 KHECQNLESEPIRNSVKERESERNQC-NFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKE 1221
Query: 402 -KVDSLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVT 460
K+ +KEK+ L+ E +Q G L T L + SQE S EI
Sbjct: 1222 LKLQESEKEKECLQHE-------------LQTIRGDLETSNLQDMQSQEISGLKDCEIDA 1268
Query: 461 PEI----REKLIRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELETE-NRLVNQ 515
E +L Q++N L+ + + + N K+ L+ + + K EL TE N ++
Sbjct: 1269 EEKYISGPHELSTSQNDNAHLQCSLQTTMN-KLNELEKICEILQAEKYELVTELNDSRSE 1327
Query: 516 RLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLE--KLHEANNELQKKRAIIEDLE 573
+ + EE+ K L + +DS LL +L E + + E NE D
Sbjct: 1328 CITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDES 1387
Query: 574 PRFNNSSLKIEELQEALRKKEEEMKQMEERYK 605
+ + +L +E+Q + +E+ ++ +K
Sbjct: 1388 NSYEHLTLSDKEVQMHFAELQEKFLSLQSEHK 1419
Score = 62.4 bits (150), Expect = 1e-09
Identities = 116/605 (19%), Positives = 247/605 (40%), Gaps = 104/605 (17%)
Query: 130 EQKQEYIQAIMMMEESVQHVVMT--AIQELMSKESPVSAGNDAYVDLDRQLKKTTEELNE 187
++ QE++ + EE Q++++ +Q+ + E T+ N
Sbjct: 1080 KEHQEFLTKLAFAEERNQNLMLELETVQQALRSEM-------------------TDNQNN 1120
Query: 188 ALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSDSIEDPNSPAGRRHL-- 245
+ S + Q L + +Q+E + LL EN+ LM+ + ++ S R +
Sbjct: 1121 SKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKE 1180
Query: 246 ------------QLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLA 293
Q+ +++++ +++ + + + +R +EL+ L++ E L
Sbjct: 1181 RESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELK-----LQESEKEKECLQ 1235
Query: 294 DEAQSLKDEIDVLRHSSDKVSKLEG----QVESYKKKLEDLGDLRRQVKLLEEKNTMYMQ 349
E Q+++ +++ + ++ G ++++ +K + +L + + ++Q
Sbjct: 1236 HELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTS-----QNDNAHLQ 1290
Query: 350 NTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKE 409
SL+ + K N E + + EL L++ + +++ E+V L E
Sbjct: 1291 --CSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITAT---RKMAEEVGKLLNE 1345
Query: 410 KDRLRTERDSLK-ETIEELRCVQ--AQEGQLTTQGLMPLGSQESSDSLA-----AEIVTP 461
L + L E +E++ + Q + L PL S + L ++
Sbjct: 1346 VKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFA 1405
Query: 462 EIREKLIRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQ 521
E++EK + LQ E+K+L +Q + K++ LQ+ +D L+ EN +++ L Q
Sbjct: 1406 ELQEKFLSLQSEHKILH-DQHCQMSSKMSELQTYVDS-------LKAENLVLSTNLRNFQ 1457
Query: 522 SQ-VEELQKSLQD------QGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEP 574
V+E+Q L++ S DS L + + A E +++ +LE
Sbjct: 1458 GDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDS---SFYRALLEQTGDMSLLSNLEG 1514
Query: 575 RFNNSSLKIEEL------QEALRKKE---------EEMKQMEERYKKYLEKAKSVIRTLD 619
+ + ++E+ +E L +KE EE++ + E Y++ LEK + + +
Sbjct: 1515 AVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQG 1574
Query: 620 PKQNQGAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQREMEEKYIVSAWYNMGMTL--H 677
+N+ EIQ L+ L + L K+Y S+ E ++ + S M L
Sbjct: 1575 IMKNK----EIQELEQLLSSERQELDCLRKQY---LSENEQWQQKLTSVTLEMESKLAAE 1627
Query: 678 KKAAE 682
KK E
Sbjct: 1628 KKQTE 1632
Score = 40.8 bits (94), Expect = 0.004
Identities = 52/215 (24%), Positives = 92/215 (42%), Gaps = 14/215 (6%)
Query: 505 ELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQK 564
ELE + + + + Q Q++ L+ +LQ Q K E+ L+ ++L E L+K
Sbjct: 22 ELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICESLEK 81
Query: 565 -KRAIIEDL---EPRFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDP 620
K+ I +L E + N ++ ++ + K E+E+K R K LE+++ ++ D
Sbjct: 82 TKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELK----RCKSELERSQQAAQSADV 137
Query: 621 KQNQGAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQREMEEKYIVSAWYNMGMTLHKKA 680
N P Q + + + + E K K +E+EE+ + A L K
Sbjct: 138 SLNPCNTP--QKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVK---ALQAKK 192
Query: 681 AEDRLASTGSGQSFLARQRQATSSRRSYPGHVQPA 715
A L +AR QA+SS S+ P+
Sbjct: 193 ASQTLPQATMNHRDIAR-HQASSSVFSWQQEKTPS 226
Score = 33.5 bits (75), Expect = 0.71
Identities = 75/416 (18%), Positives = 159/416 (38%), Gaps = 46/416 (11%)
Query: 345 TMYMQNTVSLEEELRKANAARSQ----LETYKRQVVELQNRLSEESKKADKLDFEYKRLK 400
T +Q LE +L K + Q L++ + + + + ++ E + L E +RL
Sbjct: 14 TRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLM 73
Query: 401 EKVDSLQKEKDRLRTE--------------RDSLKETIEEL-----RCVQAQE--GQLTT 439
E +SL+K K ++ E +S K+ IE+L RC E Q
Sbjct: 74 EICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQ 133
Query: 440 QGLMPLGSQESSDSLAAEIVTP----------EIREKLIRLQHENKMLKLNQEGSDNEKI 489
+ L + + +TP +++EK + E K L+ + +K
Sbjct: 134 SADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKA 193
Query: 490 A--LLQSLLDDANLRKNELETENRLVNQRL----LEVQSQVEELQKSLQDQGSKAEDSVL 543
+ L Q+ ++ ++ +++ + Q L SQ +++ E V
Sbjct: 194 SQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVT 253
Query: 544 -LKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQMEE 602
+ L+ + + + +++ L+ + KI EL+ L+ E+EMK
Sbjct: 254 PSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVN 313
Query: 603 RYKK---YLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQRE 659
++++ LEKAK + + N+ E+ Q + + +LE++ +K
Sbjct: 314 KFQELQLQLEKAKVELIEKEKVLNK-CRDELVRTTAQYDQASTKYTALEQKLKKLTEDLS 372
Query: 660 MEEKYIVSAWYNMGMTLHKKAAEDRLASTGSGQSFLARQRQATSSRRSYPGHVQPA 715
+ + SA ++ + +K E + + +SF ++ + +Q A
Sbjct: 373 CQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQA 428
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 105 bits (261), Expect = 2e-22
Identities = 129/587 (21%), Positives = 252/587 (42%), Gaps = 85/587 (14%)
Query: 134 EYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELNEALSAKE 193
E I + ++++Q A+ +L ++E V+ A V L++Q+ L + +
Sbjct: 987 EIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRM 1046
Query: 194 EIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSD--------SIEDPNSPAGRRHL 245
++ + +L+ + QE L + Q L ERL + D IED +
Sbjct: 1047 DLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGS---- 1102
Query: 246 QLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEA--------- 296
QLQ +L++LQ LE + R ++EK S+L ++ +E++ +EA
Sbjct: 1103 QLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIE 1162
Query: 297 ---------QSLKDEID--VLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNT 345
Q ++ +++ L+H + + + +S + E + +L+R + LE++ +
Sbjct: 1163 MNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKS 1222
Query: 346 MYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDS 405
+ + + + A++ LE R L+++++E KA++ + V+
Sbjct: 1223 EFKLELDDVTSNMEQIIKAKANLEKMCR---TLEDQMNEHRSKAEE-------TQRSVND 1272
Query: 406 LQKEKDRLRTERDSLKETIEELRCV--QAQEGQLT-TQGLMPLGSQESSDSLAAEIVTPE 462
L ++ +L+TE L ++E + Q G+LT TQ L L Q + A +
Sbjct: 1273 LTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHA 1332
Query: 463 IREKLIRLQHENKMLKLNQEGSDNEKIALLQSLLDDAN---------------LRKNELE 507
++ +H+ +L+ Q + E A LQ +L AN R ELE
Sbjct: 1333 LQS----ARHDCDLLR-EQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELE 1387
Query: 508 TENRLVNQRLLEVQSQVEELQ---KSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQK 564
+ + QRL E + VE + SL+ + ++ + + L +E+ + A L K
Sbjct: 1388 EAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEI---EDLMVDVERSNAAAAALDK 1444
Query: 565 KR----AIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDP 620
K+ I+ + + ++ S ++E Q+ R E+ +++ Y++ LE ++ R
Sbjct: 1445 KQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKR---- 1500
Query: 621 KQNQGAAPEIQALKNQLQERDRLFHSLEK-----EYEKTKSQREMEE 662
+N+ EI L QL + H LEK E EK + Q +EE
Sbjct: 1501 -ENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEE 1546
Score = 95.1 bits (235), Expect = 2e-19
Identities = 128/569 (22%), Positives = 247/569 (43%), Gaps = 83/569 (14%)
Query: 175 DRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSDSIE 234
++++ EE A E+ R EL+ ++ +L +EK+ L + QV E+ N +D+ E
Sbjct: 846 EKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDL--QLQVQAEQDNLADA-E 902
Query: 235 DPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDEL-TTLA 293
+ + +QL+ +++++ E E + + +LE E SEL++ D+L TLA
Sbjct: 903 ERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLA 962
Query: 294 ----------DEAQSLKDEIDVLRHSSDKVSKLEGQV-ESYKKKLEDLGDLRRQVKLLEE 342
++ ++L +E+ L K++K + + E++++ L+DL +V L +
Sbjct: 963 KVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTK 1022
Query: 343 KNTMYMQNTVSLEEELRKANAARSQLETYKRQ-----------VVELQNRLSEESKKADK 391
Q LE L + R LE KR+ +++L+N + ++ K
Sbjct: 1023 AKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKK 1082
Query: 392 LDFEYKRLKEKVD-------SLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMP 444
DFE L +++ LQK+ L+ + L+E +E R +A+ +L +
Sbjct: 1083 KDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRE 1142
Query: 445 LGS-----QESSDSLAAEIVTPEIRE----KLIR------LQHENKMLKLNQEGSDN--- 486
L +E+ + + +I + RE K+ R LQHE L ++ +D+
Sbjct: 1143 LEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAE 1202
Query: 487 --EKIALLQSLLDDANLRKNELETENRLVN---QRLLEVQSQVEELQKSLQDQ----GSK 537
E+I LQ + K+E + E V +++++ ++ +E++ ++L+DQ SK
Sbjct: 1203 LGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSK 1262
Query: 538 AEDSVLLKKKLEEHLEKLHEANNELQK----KRAII--------------EDLEPRFNNS 579
AE++ L KL N EL + K A+I EDL+ +
Sbjct: 1263 AEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEE 1322
Query: 580 SLKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQE 639
L AL+ + + E+Y++ E + R L ++ A + + +Q
Sbjct: 1323 VKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQR 1382
Query: 640 RDRLFHSLEKEYEKTKSQREMEEKYIVSA 668
+ L +E +K +QR E + V A
Sbjct: 1383 TEEL-----EEAKKKLAQRLQEAEEAVEA 1406
Score = 94.0 bits (232), Expect = 4e-19
Identities = 136/607 (22%), Positives = 243/607 (40%), Gaps = 129/607 (21%)
Query: 170 AYVDLDRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSL---LAENQVLMER 226
A +L++ + +++NE S EE + ++L Q A LQ E L L E + L+ +
Sbjct: 1241 AKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQ 1300
Query: 227 LNQ-----SDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISE 281
L + + +ED L+ QLE+ + L A R C+ L ++ E
Sbjct: 1301 LTRGKLTYTQQLED-----------LKRQLEEEVKAKNALAHALQSARHDCDLLREQYEE 1349
Query: 282 LRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLE 341
+ EL + +A S + ++ +D + + E E+ KK + L + V+ +
Sbjct: 1350 ETEAKAELQRVLSKANSEVAQWRT-KYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVN 1408
Query: 342 ------EKNTMYMQNTVS-LEEELRKANAARSQLET-----------YKRQVVELQNRLS 383
EK +QN + L ++ ++NAA + L+ +K++ E Q+ L
Sbjct: 1409 AKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELE 1468
Query: 384 EESKKADKLDFEYKRLK-------EKVDSLQKEKDRLRTERDSLKE-------TIEELRC 429
K+A L E +LK E +++ ++E L+ E L E TI EL
Sbjct: 1469 SSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEK 1528
Query: 430 VQAQ------EGQLTTQGLMPLGSQESSDSLAAEI----VTPEIREKLIRLQHENKMLKL 479
V+ Q E Q + E L A++ + EI KL E + K
Sbjct: 1529 VRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKR 1588
Query: 480 N--------------QEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVE 525
N + S NE + + + + D N E+E + N+ E Q QV+
Sbjct: 1589 NHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLN----EMEIQLSHANRMAAEAQKQVK 1644
Query: 526 ELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANN----ELQKKRAIIEDLEP------- 574
LQ L+D + +D+V L+E++ + NN EL++ RA++E E
Sbjct: 1645 SLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQ 1704
Query: 575 ------------RFNNSSL---------KIEELQEALRKKEEEMKQMEERYKKYLEKAKS 613
N+SL + +LQ + + +E + EE+ KK + A
Sbjct: 1705 ELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAM 1764
Query: 614 VIRTLDPKQNQGAAPE---------IQALKNQLQERDRL--------FHSLEKEYEKTKS 656
+ L +Q+ A E I+ L+++L E +++ LE + ++
Sbjct: 1765 MAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEN 1824
Query: 657 QREMEEK 663
+ E E+K
Sbjct: 1825 ELEAEQK 1831
Score = 87.4 bits (215), Expect = 4e-17
Identities = 123/624 (19%), Positives = 262/624 (41%), Gaps = 86/624 (13%)
Query: 93 QQINDFTLPDVNLIGEHSDAAELGRMLQLILGCAVNCEQKQEYIQAIMMMEESVQHVVMT 152
Q+ ND L + E + A+ ++ + E K + + + EE + +
Sbjct: 882 QEKNDLQL---QVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTA 938
Query: 153 AIQELMSKESPVSAGNDAYVDLDRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEE 212
++L + S + D DL+ L K +E + + + + + LD +A L +E
Sbjct: 939 KKRKLEDECSELKRDID---DLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKE 995
Query: 213 KSSLLAENQVLMERLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRC 272
K +L +Q + L+ + ED + + ++L+ Q++ L+ + + + D
Sbjct: 996 KKALQEAHQ---QALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAK 1052
Query: 273 EELEKEISELRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGD 332
+LE +L+ + + L ++ Q L +++ K + ++ + ++ED
Sbjct: 1053 RKLE---GDLKLTQESIMDLENDKQQL----------DERLKKKDFELNALNARIEDEQA 1099
Query: 333 LRRQVKLLEEKNTMYMQNTVSLEEELRKANAARSQLETYK----RQVVELQNRLSE---- 384
L Q L++K LEEEL AR+++E + R++ E+ RL E
Sbjct: 1100 LGSQ---LQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGA 1156
Query: 385 -----ESKKADKLDFEYKRLKEKVDSLQKEKDRL---RTERDSLKETIEELRCVQAQEGQ 436
E K + +F+ R + +LQ E + DS+ E E++ +Q + +
Sbjct: 1157 TSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQK 1216
Query: 437 LTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKL--NQEGSDNEKIALLQS 494
L ++S L + VT + + + + KM + +Q K Q
Sbjct: 1217 LE--------KEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQR 1268
Query: 495 LLDDANLRKNELETENRLVNQRLLEVQS--------------QVEELQKSLQDQ------ 534
++D ++ +L+TEN ++++L E ++ Q+E+L++ L+++
Sbjct: 1269 SVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNA 1328
Query: 535 -----GSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSL-KIEELQE 588
S D LL+++ EE E E L K + + ++ ++ + EEL+E
Sbjct: 1329 LAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEE 1388
Query: 589 ALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQN---------QGAAPEIQALKNQLQE 639
A +K + +++ EE + K S+ +T QN + + AL + +
Sbjct: 1389 AKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRN 1448
Query: 640 RDRLFHSLEKEYEKTKSQREMEEK 663
D++ +++YE+++S+ E +K
Sbjct: 1449 FDKILAEWKQKYEESQSELESSQK 1472
Score = 81.3 bits (199), Expect = 3e-15
Identities = 127/557 (22%), Positives = 242/557 (43%), Gaps = 103/557 (18%)
Query: 173 DLDRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSDS 232
+L+ KK + L EA A E + +C L+ LQ E L+ + +ER N + +
Sbjct: 1385 ELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVD----VERSNAAAA 1440
Query: 233 IEDPNSPAGRRHLQLQTQLEQLQEET-FRLEAAKDDYRIRCEELEKEISELRQQNDELTT 291
D R ++ + +Q EE+ LE+++ + R EL K + + + L T
Sbjct: 1441 ALDKKQ---RNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLET 1497
Query: 292 LADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLE-EKNTMYMQN 350
E ++L++EI S L Q+ S K + +L +R+Q++ + E + +
Sbjct: 1498 FKRENKNLQEEI----------SDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEA 1547
Query: 351 TVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEK 410
SLE E + R+QLE + + E++ +L+E+ ++ ++ + R+ VDSLQ
Sbjct: 1548 EASLEHE--EGKILRAQLE-FNQIKAEIERKLAEKDEEMEQAKRNHLRV---VDSLQTSL 1601
Query: 411 D---RLRTERDSLKETIE------ELRCVQAQ----EGQLTTQGLMPL---------GSQ 448
D R R E +K+ +E E++ A E Q + L L +
Sbjct: 1602 DAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAV 1661
Query: 449 ESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELET 508
++D L I E R L LQ E + L+ E ++ + Q L++ + R L +
Sbjct: 1662 RANDDLKENIAIVERRNNL--LQAELEELRAVVEQTERSRKLAEQELIETSE-RVQLLHS 1718
Query: 509 ENR-LVNQR------LLEVQSQVEELQKSLQDQGSKAE----DSVLLKKKLEE------H 551
+N L+NQ+ L ++Q++VEE + ++ KA+ D+ ++ ++L++ H
Sbjct: 1719 QNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAH 1778
Query: 552 LEKLHE-----------------------ANNELQKKRAIIEDLEPRFNNSSLKIEELQE 588
LE++ + +LQK A + +LE + E +
Sbjct: 1779 LERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVK 1838
Query: 589 ALRKKEEEMKQM---EERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRLFH 645
+RK E +K++ E +K L + + ++ L K ++A K Q +E + +
Sbjct: 1839 GMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLK--------VKAYKRQAEEAEEQAN 1890
Query: 646 SLEKEYEKTKSQREMEE 662
+ ++ K Q E++E
Sbjct: 1891 TNLSKFRKV--QHELDE 1905
Score = 79.7 bits (195), Expect = 9e-15
Identities = 103/467 (22%), Positives = 200/467 (42%), Gaps = 53/467 (11%)
Query: 248 QTQLEQLQEETFRLEAAKDDYRIRCEELE-KEISELRQQNDELTTLADEAQSLKDEIDVL 306
+ ++ ++EE RL+ A + R +ELE K +S L+++ND + E +L D +
Sbjct: 846 EKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERC 905
Query: 307 RHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAARS 366
+LE +V+ ++LED ++ ++ + K LE+E +
Sbjct: 906 DQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRK----------LEDECSEL----- 950
Query: 367 QLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRLRTERDSLKETIEE 426
KR + +L+ L++ K+ + + K L E++ L + +L E+ +L+E ++
Sbjct: 951 -----KRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQ 1005
Query: 427 -LRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSD 485
L +QA+E ++ T + ++ D L + +EK +R+ E KL +
Sbjct: 1006 ALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLE----QEKKVRMDLERAKRKLEGD--- 1058
Query: 486 NEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLK 545
+ L Q + D LE + + +++RL + ++ L ++D+ +
Sbjct: 1059 ---LKLTQESIMD-------LENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKL 1108
Query: 546 KKLEEHLEKLHEANNELQKKRAIIE----DLEPRFNNSSLKIEELQEALRKKEEEMKQME 601
K+L+ +E+L E + RA +E DL S ++EE A + E K+ E
Sbjct: 1109 KELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKRE 1168
Query: 602 ERYKKY---LEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQR 658
++K LE+A + A + L Q+ R+ LEKE KS+
Sbjct: 1169 AEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKE----KSEF 1224
Query: 659 EMEEKYIVSAWYNMGMTLHKKAAEDRLASTGSGQSFLARQRQATSSR 705
++E + S NM + KA +++ T Q R + + R
Sbjct: 1225 KLELDDVTS---NMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQR 1268
Score = 77.8 bits (190), Expect = 3e-14
Identities = 108/529 (20%), Positives = 222/529 (41%), Gaps = 74/529 (13%)
Query: 130 EQKQEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELNEAL 189
E KQ+Y ++ +E S Q + EL ++ + R+ K EE+++
Sbjct: 1455 EWKQKYEESQSELESS-QKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLT 1513
Query: 190 SAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSD-SIEDPNSPAGRRHL--- 245
+ HEL+ + + L AE L L +++ S+E R L
Sbjct: 1514 EQLGSSGKTIHELE-------KVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFN 1566
Query: 246 QLQTQLEQ-LQEETFRLEAAKDDYRIRCEELEKEI-SELRQQNDELTTLADEAQSLKDEI 303
Q++ ++E+ L E+ +E AK ++ + L+ + +E R +N+ L L +
Sbjct: 1567 QIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEME 1626
Query: 304 DVLRHSSDKVSKLEGQVESYKKKLEDL-----------GDLRRQVKLLEEKNTMYMQNTV 352
L H++ ++ + QV+S + L+D DL+ + ++E +N +
Sbjct: 1627 IQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNL------ 1680
Query: 353 SLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDR 412
L+ EL + A Q E ++ + L E S++ L + L + + + +
Sbjct: 1681 -LQAELEELRAVVEQTERSRKLA---EQELIETSERVQLLHSQNTSLINQKKKMDADLSQ 1736
Query: 413 LRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQH 472
L+TE ++E ++E R + + + T M + E++++ H
Sbjct: 1737 LQTE---VEEAVQECRNAEEKAKKAITDAAM---------------MAEELKKEQDTSAH 1778
Query: 473 ENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQ 532
+M K N E + I LQ LD+A + + ++L +++++V EL+ L+
Sbjct: 1779 LERMKK-NME----QTIKDLQHRLDEAE------QIALKGGKKQLQKLEARVRELENELE 1827
Query: 533 DQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRK 592
+ + +SV +K E +++L E +K ++DL +++LQ ++
Sbjct: 1828 AEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDL----------VDKLQLKVKA 1877
Query: 593 KEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERD 641
+ + ++ EE+ L K + V LD + + E Q K + + RD
Sbjct: 1878 YKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRD 1926
Score = 77.0 bits (188), Expect = 6e-14
Identities = 114/558 (20%), Positives = 235/558 (42%), Gaps = 65/558 (11%)
Query: 130 EQKQEYIQAIMMMEESVQHVVMTAIQELM----SKESPVSAGNDAYVDLDRQLKKTTEEL 185
E+ E + A E +H + I++LM + +A + + D+ L + ++
Sbjct: 1401 EEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKY 1460
Query: 186 NEALSAKEEIAQRCHELDMQVAALQ-------EEKSSLLAENQVLMERLNQSDSIEDPNS 238
E+ S E + L ++ L+ E + EN+ L E + SD E S
Sbjct: 1461 EESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEI--SDLTEQLGS 1518
Query: 239 PAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEAQS 298
+G+ +L+ +QL+ E L++A ++ E E +I + + +++ + +
Sbjct: 1519 -SGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLA 1577
Query: 299 LKDE------------IDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTM 346
KDE +D L+ S D ++ + KKK+E GDL
Sbjct: 1578 EKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKME--GDLN------------ 1623
Query: 347 YMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSL 406
E E++ ++A R E K QV LQ+ L + + D LKE + +
Sbjct: 1624 --------EMEIQLSHANRMAAEAQK-QVKSLQSLLKDTQIQLDDAVRANDDLKENIAIV 1674
Query: 407 QKEKDRLRTERDSLKETIEEL---RCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEI 463
++ + L+ E + L+ +E+ R + QE T++ + L SQ +S ++ +
Sbjct: 1675 ERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTS------LINQKK 1728
Query: 464 REKLIRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQ 523
+ Q + ++ + QE + E+ A + + DA + EL+ E + L ++
Sbjct: 1729 KMDADLSQLQTEVEEAVQECRNAEEKA--KKAITDAAMMAEELKKEQD-TSAHLERMKKN 1785
Query: 524 VEELQKSLQDQGSKAEDSVLL--KKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSL 581
+E+ K LQ + +AE L KK+L++ ++ E NEL+ ++ + S
Sbjct: 1786 MEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSER 1845
Query: 582 KIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAA--PEIQALKNQLQE 639
+I+EL + + + ++++ K K K+ R + + Q + + ++++L E
Sbjct: 1846 RIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDE 1905
Query: 640 RDRLFHSLEKEYEKTKSQ 657
+ E + K +++
Sbjct: 1906 AEERADIAESQVNKLRAK 1923
Score = 32.3 bits (72), Expect = 1.6
Identities = 29/152 (19%), Positives = 63/152 (41%), Gaps = 20/152 (13%)
Query: 519 EVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNEL----QKKRAIIEDLEP 574
E + ++ +++ E S +K+LEE + L + N+L Q ++ + D E
Sbjct: 844 EREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEE 903
Query: 575 RFN-------NSSLKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLD-------- 619
R + K++E+ E L +EE ++ + +K ++ + R +D
Sbjct: 904 RCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAK 963
Query: 620 -PKQNQGAAPEIQALKNQLQERDRLFHSLEKE 650
K+ +++ L ++ D + L KE
Sbjct: 964 VEKEKHATENKVKNLTEEMAGLDEIIAKLTKE 995
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 103 bits (258), Expect = 4e-22
Identities = 128/574 (22%), Positives = 255/574 (44%), Gaps = 63/574 (10%)
Query: 119 LQLILGCAVNCEQ-KQEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDR- 176
LQ L A N Q KQ+ + I + V + + ES + + Y+ L++
Sbjct: 665 LQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQK 724
Query: 177 ------QLKKTTEELNEALSAKEEIAQRCHE-----LDMQVAALQEEKSSLLAENQVLME 225
Q+KK + E ++KE+ Q + D+++ A + K + + V
Sbjct: 725 TEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSST 784
Query: 226 RLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEI----SE 281
RL+ E S ++ L Q + +Q+ ++ F E + +I+ EEL I +E
Sbjct: 785 RLDLQKKSEALESI--KQKLTKQEEEKQILKQDF--ETLSQETKIQHEELNNRIQTTVTE 840
Query: 282 LRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLE 341
L++ E L E ++KD++ + S K SK E + E+ K K L DL + K L+
Sbjct: 841 LQKVKMEKEALMTELSTVKDKLSKVSDSL-KNSKSEFEKENQKGKAAIL-DLEKTCKELK 898
Query: 342 EKNTMYMQNTVSLEEELRKA--------NAARSQLETYKRQVVELQNRLSEESKKADKLD 393
+ + M+NT+ ++EL+K+ + + +L + + Q+++ QN L + K+ +L
Sbjct: 899 HQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQ 958
Query: 394 FEYKRLKEKVDSLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDS 453
LK+ + +K+ + L+ E LK + + ++ + Q TQ L +++ S
Sbjct: 959 GNINELKQSSEQKKKQIEALQGE---LKIAVLQKTELENKLQQQLTQAAQELAAEKEKIS 1015
Query: 454 LAAEIVTPEIREKLIRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELETENRLV 513
+ ++ + Q K L+ + G ++E +A Q L +E + L
Sbjct: 1016 V--------LQNNYEKSQETFKQLQSDFYGRESELLATRQDL--------KSVEEKLSLA 1059
Query: 514 NQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLE 573
+ L+ ++Q+ K +Q+ + K E+ L++ +A ++QK++++ E
Sbjct: 1060 QEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSL---KE 1116
Query: 574 PRFNNSSLKIEELQEALRKKEEEMKQMEERYKKY-LEKAKSVIRTLDPKQ--------NQ 624
N K+ E++E ++E+E+ ++ E K + LE K + D KQ Q
Sbjct: 1117 KELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQ 1176
Query: 625 GAAPEIQALKNQLQERDRLF-HSLEKEYEKTKSQ 657
G A ++A Q + ++ ++KE E+ K +
Sbjct: 1177 GKADSLKAAVEQEKRNQQILKDQVKKEEEELKKE 1210
Score = 101 bits (252), Expect = 2e-21
Identities = 118/551 (21%), Positives = 233/551 (42%), Gaps = 71/551 (12%)
Query: 135 YIQAIMMMEESVQHVVM---TAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELNEALSA 191
Y+Q + ++ SV + T + L+ KE + K E+ NE +
Sbjct: 286 YVQELQKLKSSVNELTQKNQTLTENLLKKEQDYT--------------KLEEKHNEESVS 331
Query: 192 KEEIAQRCHELDMQVAALQEEKS----SLLAENQVLMERLNQSDSIEDPNSPAGRRHLQL 247
K+ I H+ D+ LQ S SL + L E+ + +++ S ++ L
Sbjct: 332 KKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHL 391
Query: 248 QTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEAQSLKDE--IDV 305
+ + +QLQ++ E + +L ++ E +Q E E + L E +D
Sbjct: 392 KAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDK 451
Query: 306 LRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAAR 365
+ +D KL E K+K+ + +L+ Q L++ + + + K A+
Sbjct: 452 EQQVADLQLKLSRLEEQLKEKVTNSTELQHQ---LDKTKQQHQEQQALQQSTTAKLREAQ 508
Query: 366 SQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRLRTERDSLKETIE 425
+ LE RQ+ ++ +K L+ ++ KE + L+KE++ L +
Sbjct: 509 NDLEQVLRQI-------GDKDQKIQNLEALLQKSKENISLLEKEREDLYAK--------- 552
Query: 426 ELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSD 485
+QA EG+ + QE + +L ++ ++ EKL +K + N
Sbjct: 553 ----IQAGEGETAVLNQL----QEKNHTLQEQVT--QLTEKLKNQSESHKQAQENLHDQV 602
Query: 486 NEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLK 545
E+ A L++ D R LET +N +L E + +V +L + KA+ +LL
Sbjct: 603 QEQKAHLRAAQD----RVLSLETSVNELNSQLNESKEKVSQLDIQI-----KAKTELLLS 653
Query: 546 KKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQMEERYK 605
+ + ++ + N L + ++D + N + +++++ L+ K+E Q+E K
Sbjct: 654 AEAAKTAQRA-DLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLK 712
Query: 606 KYLEKAKSVIRTLDP-----KQNQGAAPEIQALKNQ----LQERDRLFHSLEKEYEKTKS 656
+Y EK S+ + + K+ + + E++A K Q LQ++ +L LE +
Sbjct: 713 EYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSK 772
Query: 657 QREMEEKYIVS 667
Q EME++ + S
Sbjct: 773 QLEMEKEIVSS 783
Score = 93.6 bits (231), Expect = 6e-19
Identities = 126/580 (21%), Positives = 267/580 (46%), Gaps = 72/580 (12%)
Query: 184 ELNEALSAKEEIAQRCHELDMQVAALQEEK--SSLLAENQVLMERLNQSDSIEDPNSPAG 241
E N AL + R D+Q A+L+EEK S L + + L Q ++ D
Sbjct: 75 ESNLALKRDDVTLLRQEVQDLQ-ASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDS 133
Query: 242 RRHLQ-LQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEA---- 296
LQ L+ QLE+ Q E F ++ KD + + +L EI++++ + DE +L + A
Sbjct: 134 SAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKV 193
Query: 297 ----QSLKDEIDVLRHSSDKVSKLEG--QVESYKKKLEDLGDLRRQVKLLEEKNTMYMQN 350
+ L E V++ ++ + G V KK+L + L + L E+ + +++
Sbjct: 194 TRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKD 253
Query: 351 TV-SLEEELRKANAARSQLET-----------YKRQVVELQNRLSEESKKADKLDFEYKR 398
L+ + + A SQL + Y +++ +L++ ++E ++K L +
Sbjct: 254 ECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLK 313
Query: 399 LKEKVDSLQKEKDRLRTERDSLKETI--EELRCVQAQEGQLTTQ-GLMPLGSQESSDSLA 455
++ L+++ + + +++ T+ ++L C Q Q ++ L + + S A
Sbjct: 314 KEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEA 373
Query: 456 AEIVTPEIREKLIRLQH-ENKMLKLNQEGSDNEKIAL-LQSLLDDANLRKNE-------- 505
+ + E+ E + QH + + +L Q+ + E+ L LQS ++ + + E
Sbjct: 374 TQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEA 433
Query: 506 ---LETENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNEL 562
L+ + +L +++L++ + QV +LQ L + ++ V +L+ L+K + +
Sbjct: 434 HGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQH--- 490
Query: 563 QKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQ 622
Q+++A+ + + + +E++ + K+++++ +E L+K+K I L+ K+
Sbjct: 491 QEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLE----ALLQKSKENISLLE-KE 545
Query: 623 NQGAAPEIQ------ALKNQLQERDRLFHSLEKEY----EKTKSQREMEEKYIVSAWYNM 672
+ +IQ A+ NQLQE++ H+L+++ EK K+Q E ++ A N+
Sbjct: 546 REDLYAKIQAGEGETAVLNQLQEKN---HTLQEQVTQLTEKLKNQSESHKQ----AQENL 598
Query: 673 -----GMTLHKKAAEDRLASTGSGQSFLARQRQATSSRRS 707
H +AA+DR+ S + + L Q + + S
Sbjct: 599 HDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVS 638
Score = 93.2 bits (230), Expect = 8e-19
Identities = 146/662 (22%), Positives = 275/662 (41%), Gaps = 80/662 (12%)
Query: 43 QVLQKIDPAYFDE--NWLNRIKTEVGDNWRLKISNLKKILKGILDYNHEILGQQINDFTL 100
Q LQ+ A E N L ++ ++GD + KI NL+ +L+ + N +L ++ D
Sbjct: 494 QALQQSTTAKLREAQNDLEQVLRQIGDKDQ-KIQNLEALLQKSKE-NISLLEKEREDLYA 551
Query: 101 PDVNLIGEHSDAAELGRMLQLILGCAVNCEQKQEYIQAIMMMEESVQHVVMTAIQELMSK 160
GE + +L + EQ + + + ES + ++ +
Sbjct: 552 KIQAGEGETAVLNQLQEKNHTLQ------EQVTQLTEKLKNQSESHKQAQENLHDQVQEQ 605
Query: 161 ESPVSAGNDAYVDLDRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAEN 220
++ + A D + L+ + + +LNE+ KE+++Q LD+Q+ A E L AE
Sbjct: 606 KAHLRAAQDRVLSLETSVNELNSQLNES---KEKVSQ----LDIQIKAKTE--LLLSAEA 656
Query: 221 QVLMERLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEIS 280
+R + + ++ + + +L QL + T +L+ D + C +LE S
Sbjct: 657 AKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQ----DKQEHCSQLE---S 709
Query: 281 ELRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLL 340
L++ ++ +L + + L+ +I L S +E K + L DL++Q +L
Sbjct: 710 HLKEYKEKYLSLEQKTEELEGQIKKLEADS---------LEVKASKEQALQDLQQQRQLN 760
Query: 341 EEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLS--EESKKADKLDFEY-- 396
+ + + LE E ++ R L+ + ++ +L+ EE K+ K DFE
Sbjct: 761 TDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLS 820
Query: 397 -----------KRLKEKVDSLQK---EKDRLRTE----RDSLKETIEELRCVQAQEGQLT 438
R++ V LQK EK+ L TE +D L + + L+ +++ +
Sbjct: 821 QETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKEN 880
Query: 439 TQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSDNEKIAL--LQSLL 496
+G + E + + ++ L + K L+ +E S K+ L +Q L
Sbjct: 881 QKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQL 940
Query: 497 DDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEK-L 555
A + E E + + + E++ E+ +K ++ + + +VL K +LE L++ L
Sbjct: 941 IQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQL 1000
Query: 556 HEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVI 615
+A EL ++ I L+ + S ++LQ +E E+ + K EK
Sbjct: 1001 TQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQ 1060
Query: 616 RTLDPKQNQ--GAAPEIQALK--------------NQLQERDRLFHSLEKEYEKTKSQRE 659
L +NQ IQ LK QLQER + ++KE KS +E
Sbjct: 1061 EDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKE----KSLKE 1116
Query: 660 ME 661
E
Sbjct: 1117 KE 1118
Score = 90.1 bits (222), Expect = 6e-18
Identities = 120/597 (20%), Positives = 256/597 (42%), Gaps = 81/597 (13%)
Query: 130 EQKQEYIQAIMMMEESVQ--HVVMTAIQELMSKESPVSAGNDAYVDLDRQL--------K 179
EQ+Q + +M E+ V + ++ ++E + ++ S +D +Q +
Sbjct: 439 EQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQ 498
Query: 180 KTTEELNEALSAKEEIAQRCHELDMQV----AALQEEK---SSLLAENQVLMERLNQSDS 232
TT +L EA + E++ ++ + D ++ A LQ+ K S L E + L ++ +
Sbjct: 499 STTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEG 558
Query: 233 IEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISE----LRQQNDE 288
+ ++ LQ Q+ QL E +L+ + ++ E L ++ E LR D
Sbjct: 559 ETAVLNQLQEKNHTLQEQVTQLTE---KLKNQSESHKQAQENLHDQVQEQKAHLRAAQDR 615
Query: 289 LTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKK--------KLEDLGDLRRQV--- 337
+ +L L + L S +KVS+L+ Q+++ + K DL+ +
Sbjct: 616 VLSLETSVNELNSQ---LNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTA 672
Query: 338 -KLLEEKN-------TMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKA 389
L++K T Q T L+++ + S L+ YK + + L+ + E +
Sbjct: 673 QNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQI 732
Query: 390 DKLDFEYKRLKEKVDSLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQE 449
KL+ + +K + ++ + R L+ EL E ++ + + L +
Sbjct: 733 KKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKS 792
Query: 450 SSDSLAAEIVTPEIREKLI------------RLQHENKMLKLNQEGSDNEKIAL------ 491
+ + +T + EK I ++QHE ++ ++ +K+ +
Sbjct: 793 EALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALM 852
Query: 492 ---------LQSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSV 542
L + D K+E E EN+ +L+++ +EL+ LQ Q E+++
Sbjct: 853 TELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQ---MENTL 909
Query: 543 LLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQMEE 602
+K+L++ LEK EA+++L+ + +++ + N+ + E+ ++ L+ E+KQ E
Sbjct: 910 KEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSE 969
Query: 603 RYKKYLE----KAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRLFHSLEKEYEKTK 655
+ KK +E + K + +N+ QA + E++++ L+ YEK++
Sbjct: 970 QKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKI-SVLQNNYEKSQ 1025
Score = 79.3 bits (194), Expect = 1e-14
Identities = 113/506 (22%), Positives = 228/506 (45%), Gaps = 82/506 (16%)
Query: 142 MEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQ--------LKKTTEELNEALSAK- 192
ME+ ++ +++ +SK S + + + + Q L+KT +EL L +
Sbjct: 846 MEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQM 905
Query: 193 EEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSDSIEDPNSPAGRRHLQLQTQLE 252
E + EL + +E L E + E+L Q+ + N + QLQ +
Sbjct: 906 ENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNE---KEEQQLQGNIN 962
Query: 253 QLQEETFR----LEAAKDDYRIRCEELEKEISELRQQNDELTTLADEAQSLKDEIDVLRH 308
+L++ + + +EA + + +I + + ++L+QQ LT A E + K++I VL++
Sbjct: 963 ELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQ---LTQAAQELAAEKEKISVLQN 1019
Query: 309 SSDKVSKLEGQVES--YKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAARS 366
+ +K + Q++S Y ++ E L R+ +K +EEK ++ ++ +S ++ N
Sbjct: 1020 NYEKSQETFKQLQSDFYGRESELLAT-RQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQ 1078
Query: 367 QLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKD----RLRTERDSLKE 422
+L+T K + + + +KK +L K L++ +QKEK L E+ L E
Sbjct: 1079 ELKTAKATLEQ------DSAKKEQQLQERCKALQD----IQKEKSLKEKELVNEKSKLAE 1128
Query: 423 TIEELRCVQAQE-------------------------GQLTTQGLMPLGSQESSDSLAAE 457
IEE++C Q +E QL Q + L Q +DSL A
Sbjct: 1129 -IEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLEL--QGKADSLKAA 1185
Query: 458 IVTPEIREKLIRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELETENRL----- 512
+ + +++++ Q + + +L +E + E + + ++K+E E E +L
Sbjct: 1186 VEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHE-ENEAKLTMQIT 1244
Query: 513 -VNQRLLEV-------QSQVEELQKSLQD-QGSKAEDSVLLKKKLEEH---LEKLHEANN 560
+N+ L V Q +V EL+K D +G A ++ +E LE+ +
Sbjct: 1245 ALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEG 1304
Query: 561 ELQKKRAIIEDLEPRFNNSSLKIEEL 586
E++K + + +L+ + +N++ ++EL
Sbjct: 1305 EIEKLQTKVLELQRKLDNTTAAVQEL 1330
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 103 bits (257), Expect = 6e-22
Identities = 133/600 (22%), Positives = 272/600 (45%), Gaps = 81/600 (13%)
Query: 119 LQLILGCAVNCEQKQEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQL 178
L+ L A E+ + ++A M+E ++ + T+ +E +S + +S VD+ +
Sbjct: 416 LEKALSTAQKTEEARRKLKA--EMDEQIKTIEKTSEEERISLQQELSRVKQEVVDV---M 470
Query: 179 KKTTEELNEALSA--KEEIAQRCHELDMQVAA----LQEEKSSLLAENQVLMERLNQSDS 232
KK++EE L ++E+A++ EL ++ QE+ L ++Q E L S
Sbjct: 471 KKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQ--SEYLKISQE 528
Query: 233 IEDPNSPAGRR-HLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEI------------ 279
E S A LQ + L + + + L+ + YR R ELE +
Sbjct: 529 KEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSK 588
Query: 280 -------SELRQQNDELTTLADEAQSLKDEIDVLRHSSDKV--SKLEGQVESYKKKLEDL 330
+E + N E+T + ++ K E++ L+H D + KL+ + Y+ ++E L
Sbjct: 589 DLAVHLEAEKNKHNKEITVMVEKH---KTELESLKHQQDALWTEKLQVLKQQYQTEMEKL 645
Query: 331 GDLRRQVK--LLEEKNTMYMQNTVSLEEE-LRKANAARSQLETYKRQVVELQNRLSEESK 387
+ Q K LL++K ++ + + E+ L K + +++LE+ L + LSE K
Sbjct: 646 REKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELES-------LSSELSEVLK 698
Query: 388 KADKLDFEYKRLKEKVDSLQKEKD-RLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLG 446
KL+ E LK++ D +++E + ++ +++ ++ ++ + +
Sbjct: 699 ARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSI-----------------IK 741
Query: 447 SQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSDNEKIALLQSL--LDDANLRKN 504
E S + + +I + + L+ +K LK +Q +N + + +S L A+ + +
Sbjct: 742 EHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLD 801
Query: 505 ELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQK 564
++ +++ + Q+ +LQ+ L D + + +LL K++ E + + EL
Sbjct: 802 VFQSYQSATHEQTKAYEEQLAQLQQKLLDLET---ERILLTKQVAEVEAQKKDVCTELDA 858
Query: 565 KRAIIEDL----EPRFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDP 620
+ ++DL E + + K++ L + K E+ + +E+ K+ L + +++I +
Sbjct: 859 HKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQM-- 916
Query: 621 KQNQGAAPEIQALKNQLQERDRLFHSLEKEYE-KTKSQREMEEKYIVSAWYNMGMTLHKK 679
+G EI+ L +L ++ H L +EYE K K+Q + EK A M TL KK
Sbjct: 917 --REGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKA-KEMQETLKKK 973
Score = 101 bits (251), Expect = 3e-21
Identities = 131/543 (24%), Positives = 230/543 (42%), Gaps = 107/543 (19%)
Query: 138 AIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELNEALSAKEEIAQ 197
AI+ QH + L+ K VS +L+ QL++ TEE N + ++
Sbjct: 1245 AILSRISHCQHRTTKVKEALLIKTCTVS-------ELEAQLRQLTEEQNTLNISFQQATH 1297
Query: 198 RCHELDMQVAALQEEKSSLLAENQVLM-ERLNQSDSIEDPNSPAGRRHLQLQTQL----- 251
+ E + Q+ +++ + SL+ E + L E NQ + + S + +L +
Sbjct: 1298 QLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTL 1357
Query: 252 --EQLQEETFRLEAAKDDY---------RIRCEELEKEISELRQQND-ELTTLADEAQSL 299
E+L+E+ + + I E E IS LR+Q D E L D+ Q L
Sbjct: 1358 MKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDL 1417
Query: 300 KDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELR 359
++D L S +K+S LE QV+ + K +
Sbjct: 1418 SFKVDTL--SKEKISALE-QVDDWSNKFSEW----------------------------- 1445
Query: 360 KANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRLRTERDS 419
A+S+ ++ V ELQ +L +SK+A + D + LKE++D K D L+ E +
Sbjct: 1446 -KKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMED 1504
Query: 420 LKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPE--IREKLIRLQHENKML 477
K +E+ +E L T+ L SQ A I+ E I +K I ++ N++L
Sbjct: 1505 DKSKMEK------KESNLETE----LKSQ------TARIMELEDHITQKTIEIESLNEVL 1548
Query: 478 KLNQEGSDNEKIALLQSLLDDANLRKNELETENRL--VNQRLLEVQSQVEELQKSLQDQG 535
K + D E L+Q L L + E +NR+ +++L +++QV ++ L+ +
Sbjct: 1549 KNYNQQKDIEHKELVQKLQHFQELGE---EKDNRVKEAEEKILTLENQVYSMKAELETKK 1605
Query: 536 SKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKEE 595
+ E L K EE L+ L + L+ + A + LK + Q+ K++
Sbjct: 1606 KELEHVNLSVKSKEEELKALED---RLESESAA--------KLAELKRKAEQKIAAIKKQ 1654
Query: 596 EMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRLFHSLEKEYEKTK 655
+ QMEE+ ++Y +G + L +LQER+R H LE++ + +
Sbjct: 1655 LLSQMEEKEEQY---------------KKGTESHLSELNTKLQEREREVHILEEKLKSVE 1699
Query: 656 SQR 658
S +
Sbjct: 1700 SSQ 1702
Score = 89.4 bits (220), Expect = 1e-17
Identities = 129/603 (21%), Positives = 251/603 (41%), Gaps = 98/603 (16%)
Query: 132 KQEYIQAIMMMEESVQHV------VMTAIQELMSKESPVSAGNDAYVDLD-RQLKKTTEE 184
K++ IQ + ME S+ ++TA Q L ++ + D R++ + EE
Sbjct: 136 KEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREE 195
Query: 185 LNEALSAK----EEIAQRCHELDMQVAALQEEKSSL----------------LAENQVLM 224
L AK EE E D ++ LQ + S L L + +
Sbjct: 196 LQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQA 255
Query: 225 ERLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQ 284
E + ++ E P ++T LE LQ+ R E + RC+E ++
Sbjct: 256 EVFTKEENPESDGEPVVEDGTSVKT-LETLQQRVKRQE----NLLKRCKET------IQS 304
Query: 285 QNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKN 344
++ T L E ++L++++D +K+ L + K + L D + ++ LE+
Sbjct: 305 HKEQCTLLTSEKEALQEQLDERLQELEKIKDLH--MAEKTKLITQLRDAKNLIEQLEQDK 362
Query: 345 TMYMQNTV-SLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKV 403
M + T + E L +QL + +Q+ L E+ +K+++ FE L++ +
Sbjct: 363 GMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFE--ELEKAL 420
Query: 404 DSLQKEKD---RLRTERD----SLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAA 456
+ QK ++ +L+ E D ++++T EE R QE Q ++ + + S + +A
Sbjct: 421 STAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAK 480
Query: 457 EIVTPEIREK-LIRLQHE--NKMLKLNQEGSDNEKIALLQSLLDDANLRKNELETENRLV 513
++ EK L R + E K+ +E + K+AL +S + + + + + E+ +
Sbjct: 481 ---LQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLAL 537
Query: 514 NQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLE 573
+ L+ ++ + E + L+D +AE +LE LEK + N K A+ + E
Sbjct: 538 EELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAE 597
Query: 574 PRFNNSSL------------------------KIEELQEALRKKEEEMKQMEERYKKYLE 609
+N + K++ L++ + + E++++ E+ K+ L
Sbjct: 598 KNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLL 657
Query: 610 KAKSVI-------------RTLDPKQNQGAAPEIQALKNQLQERDRLFHSLEKEYEKTKS 656
K K +I LD KQ E+++L ++L E + H LE+E K
Sbjct: 658 KDKEIIFQAHIEEMNEKTLEKLDVKQT-----ELESLSSELSEVLKARHKLEEELSVLKD 712
Query: 657 QRE 659
Q +
Sbjct: 713 QTD 715
Score = 82.0 bits (201), Expect = 2e-15
Identities = 119/578 (20%), Positives = 251/578 (43%), Gaps = 85/578 (14%)
Query: 130 EQKQEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELNEAL 189
++ + Y I+ +E S++ S + + D V L+ + K +E+ +
Sbjct: 560 QEAETYRTRILELESSLEK----------SLQENKNQSKDLAVHLEAEKNKHNKEITVMV 609
Query: 190 SA-KEEIAQRCHELDMQVAALQEEKSSLLAEN-QVLMERLNQSDSIEDPNSPAGRRHLQL 247
K E+ H+ D AL EK +L + Q ME+L + ++ + + +
Sbjct: 610 EKHKTELESLKHQQD----ALWTEKLQVLKQQYQTEMEKLREKCE-QEKETLLKDKEIIF 664
Query: 248 QTQLEQLQEETF-RLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEAQSLKDEIDVL 306
Q +E++ E+T +L+ + + EL + + + +EL+ L D+ +K E++
Sbjct: 665 QAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAK 724
Query: 307 -----RHSSDKVSKLEGQVE-SYKKKLEDLGDLRRQVKLLEEKNTMYMQ----NTVSLEE 356
H +V + + E S ++ + L D Q++LL ++ +++ + +LE
Sbjct: 725 MDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEA 784
Query: 357 ELRKA------------------NAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKR 398
+++++ +A Q + Y+ Q+ +LQ +L LD E +R
Sbjct: 785 DIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKL---------LDLETER 835
Query: 399 --LKEKVDSLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAA 456
L ++V ++ +K + TE D+ K +++L +Q E Q + + +S
Sbjct: 836 ILLTKQVAEVEAQKKDVCTELDAHKIQVQDL--MQQLEKQNSEMEQKVKSLTQVYESKLE 893
Query: 457 EIVTPEIREKLIRLQHENKMLKLNQEGSDNEKIALLQSLL---DDANLRKNELETENRLV 513
+ + + K I ++ EN +L++ +EG E L Q L D ++ E ET+ +
Sbjct: 894 DGNKEQEQTKQILVEKENMILQM-REGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQ 952
Query: 514 NQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLE 573
+++ +V+ + +E+Q++L KKKL + KL + EL+ + E
Sbjct: 953 EKKMEKVKQKAKEMQETL-------------KKKLLDQEAKLKK---ELENTALELSQKE 996
Query: 574 PRFNNSSLKIEELQEA------LRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAA 627
+FN L++ + A R + + +Q+E + + + VI + K NQ A
Sbjct: 997 KQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAE 1056
Query: 628 PEIQALKNQLQERDRLFHSLEKEYEKTKSQREMEEKYI 665
+ + QLQE+++ L+++ ++E K I
Sbjct: 1057 ELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEI 1094
Score = 77.8 bits (190), Expect = 3e-14
Identities = 105/521 (20%), Positives = 217/521 (41%), Gaps = 70/521 (13%)
Query: 149 VVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELNEALSAKEEIAQRCHELDMQVAA 208
V T ++ L S+ S V + LK T+++ + L AK + Q+ H +
Sbjct: 681 VKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMD-EQKNHHQQQVDSI 739
Query: 209 LQEEKSSLLAENQVLMERLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLE------ 262
++E + S+ + L +++NQ + + + H Q +E L+ + R E
Sbjct: 740 IKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEH---QAHVENLEADIKRSEGELQQA 796
Query: 263 AAKDD---------------YRIRCEELEKEISELRQQNDELTTLADEAQSLKDEI---- 303
+AK D Y + +L++++ +L + LT E ++ K ++
Sbjct: 797 SAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTEL 856
Query: 304 --------DVLRHSSDKVSKLEGQVES----YKKKLEDLGDLRRQVK-LLEEKNTMYMQN 350
D+++ + S++E +V+S Y+ KLED + Q K +L EK M +Q
Sbjct: 857 DAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQM 916
Query: 351 TVSLEEEL----RKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKV--- 403
++E+ +K +A + E + + + KK +K+ + K ++E +
Sbjct: 917 REGQKKEIEILTQKLSAKEDSIHILNE---EYETKFKNQEKKMEKVKQKAKEMQETLKKK 973
Query: 404 --DSLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQ-ESSDSLAAEIVT 460
D K K L L + ++ + Q + G+ S+ E++ E +T
Sbjct: 974 LLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLT 1033
Query: 461 PEIREKL--IRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLR---------KNELETE 509
R +L + E K+ + +E + +I L + + A L+ K E+ E
Sbjct: 1034 EVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKE 1093
Query: 510 NRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAII 569
+ + ++ + + ELQ+ L+ + + + KL+ HLEKL N+ K+ +
Sbjct: 1094 ITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFL 1153
Query: 570 E----DLEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKK 606
+ +L+ K+ EL L+ +EE + ++ ++K
Sbjct: 1154 QEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEK 1194
Score = 71.2 bits (173), Expect = 3e-12
Identities = 124/599 (20%), Positives = 251/599 (41%), Gaps = 98/599 (16%)
Query: 130 EQKQEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELNEAL 189
E+K ++ ++++ V + EL +K+ + N + + +LK + L
Sbjct: 1574 EEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESES 1633
Query: 190 SAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSDSIEDPNSPAGRRHLQLQT 249
+AK +A+ + + ++AA++++ S + E + ++ +S + + N+ R ++
Sbjct: 1634 AAK--LAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESH-LSELNTKLQEREREVHI 1690
Query: 250 QLEQL------QEETFRLEAAKDDYRIRCEE------------LEKEISELRQQNDELTT 291
E+L Q ET + + + E+ E++IS L++ E
Sbjct: 1691 LEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEK 1750
Query: 292 LADEAQSLKDE-----IDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTM 346
L K+E ++ +++ KLE + +G L+ + LEEKN
Sbjct: 1751 LLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEE---LEEKNKK 1807
Query: 347 YMQNTVS-LEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDS 405
Y +E+E K N Q + ++Q L E+ L+ +++KE
Sbjct: 1808 YSLIVAQHVEKEGGKNNIQAKQ--NLENVFDDVQKTLQEKELTCQILE---QKIKELDSC 1862
Query: 406 LQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDS------------ 453
L ++K+ R E + L E+L+ +Q +G+ L+ ++E S S
Sbjct: 1863 LVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNME 1922
Query: 454 -------------------LAAEIVTPEIREKLIRLQHENKMLKLNQEGSDNEKIALLQS 494
L EIV + +++R +H+ ++ L +E D E+ ++
Sbjct: 1923 AQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKE-YDQEREEKIKQ 1981
Query: 495 LLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEK 554
+D L+ N T +L+ + ++ + +EL+ ++++ +KA++ E LE
Sbjct: 1982 EQEDLELKHN--STLKQLMREFNTQLAQKEQELEMTIKETINKAQEVE------AELLES 2033
Query: 555 LHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEEM--------KQMEERYKK 606
E N+L KK I + + ++ + EE+ +A +EEEM Q+EE KK
Sbjct: 2034 HQEETNQLLKK---IAEKDDDLKRTAKRYEEILDA---REEEMTAKVRDLQTQLEELQKK 2087
Query: 607 YLEKAKSVIRTLDPKQNQG-AAPEIQALKNQLQERDRLF-HSLEKEYEKTKSQREMEEK 663
Y +K L+ ++N G I L+ QL ++ L S KE E + +E++
Sbjct: 2088 YQQK-------LEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDR 2139
Score = 65.5 bits (158), Expect = 2e-10
Identities = 127/611 (20%), Positives = 267/611 (43%), Gaps = 106/611 (17%)
Query: 133 QEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVD-LDRQLKKTTEELNEALSA 191
+E+ +I E++++ + ++ L+ + + A+V+ L+ +K++ EL +A SA
Sbjct: 741 KEHEVSIQRTEKALKDQI-NQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQA-SA 798
Query: 192 KEEIAQR----CHE----LDMQVAALQEEKSSLLAENQVLMERLNQSDSIE-DPNSPAGR 242
K ++ Q HE + Q+A LQ++ L E +L +++ + ++ + D +
Sbjct: 799 KLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDA 858
Query: 243 RHLQLQTQLEQLQEETFRLE----AAKDDYRIRCEELEKEISELRQ-------------- 284
+Q+Q ++QL+++ +E + Y + E+ KE + +Q
Sbjct: 859 HKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMRE 918
Query: 285 -QNDELTTLADEAQSLKDEIDVLRHSSD-KVSKLEGQVESYKKKLEDLGD-LRRQVKLLE 341
Q E+ L + + +D I +L + K E ++E K+K +++ + L++++ E
Sbjct: 919 GQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQE 978
Query: 342 EKNTMYMQNT---VSLEE--------ELRKANAAR-----SQLETYKRQVVELQNRLSEE 385
K ++NT +S +E E+ +AN+A S+LET +++ +E +
Sbjct: 979 AKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRR 1038
Query: 386 SKKADKLDFEYKRLKEKVDSLQKEKDRLRTERDS----LKETIEELRCVQAQEGQLTT-- 439
D + K+L ++ + LQ+ + E++ LK+ I C + + + T
Sbjct: 1039 ELN-DVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWL 1097
Query: 440 ------QGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSDN----EKI 489
Q QE +A + + E ++ E + LN+ +N E++
Sbjct: 1098 KEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQL 1157
Query: 490 ALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLE 549
L+ L ++ + +EL ++ + ++ ++S E+ KSL+D+ L KKL
Sbjct: 1158 VELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKS-------LEFKKLS 1210
Query: 550 EHL-----------EKLHEA-NNEL-----QKKRAIIEDLEPRFNNSSLKIEELQEALRK 592
E L E L EA NEL K AI+ R ++ + +++EAL
Sbjct: 1211 EELAIQLDICCKKTEALLEAKTNELINISSSKTNAILS----RISHCQHRTTKVKEALLI 1266
Query: 593 KEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRLFHSLEKEYE 652
K + ++E + +R L +QN Q +QL+E++ S++ + E
Sbjct: 1267 KTCTVSELEAQ-----------LRQLTEEQNT-LNISFQQATHQLEEKENQIKSMKADIE 1314
Query: 653 KTKSQREMEEK 663
+++E +K
Sbjct: 1315 SLVTEKEALQK 1325
Score = 62.0 bits (149), Expect = 2e-09
Identities = 90/454 (19%), Positives = 198/454 (43%), Gaps = 52/454 (11%)
Query: 161 ESPVSAGNDAYVDLDRQLKKTTEELNEALSAKEEIAQRCHELDMQVA---ALQEEKSSLL 217
E +S + ++ L++ +E E +S+ E+ + E +++ A Q E S++
Sbjct: 1735 EEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMI 1794
Query: 218 AENQVLMERLNQSDSI---EDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEE 274
Q +E N+ S+ + G+ ++Q + LE + ++ + K+ + C+
Sbjct: 1795 GHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKE---LTCQI 1851
Query: 275 LEKEISELRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLR 334
LE++I EL + L + + + E++ L +K+ L+ Q++ K E
Sbjct: 1852 LEQKIKELD------SCLVRQKEVHRVEMEELTSKYEKLQALQ-QMDGRNKPTE------ 1898
Query: 335 RQVKLLEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADK-LD 393
LLEE ++ + + L A + LE + +L +E + K L
Sbjct: 1899 ----LLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLR 1954
Query: 394 FEYKRLKEKVDSLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDS 453
K +++++ L+KE D+ R E+ +K+ E+L + + Q + +Q +
Sbjct: 1955 MLRKEHQQELEILKKEYDQEREEK--IKQEQEDL---ELKHNSTLKQLMREFNTQLAQKE 2009
Query: 454 LAAEIVTPEIREKLIRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELETENRLV 513
E+ E K ++ E +L+ +QE ++ LL+ + + + K + ++
Sbjct: 2010 QELEMTIKETINKAQEVEAE--LLESHQEETNQ----LLKKIAEKDDDLKRTAKRYEEIL 2063
Query: 514 NQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLE 573
+ R E+ ++V +LQ L++ L+KK ++ LE+ N+ I +L+
Sbjct: 2064 DAREEEMTAKVRDLQTQLEE----------LQKKYQQKLEQEENPGND----NVTIMELQ 2109
Query: 574 PRFNNSSLKIEELQEALRKKEEEMKQMEERYKKY 607
+ + I + + ++ E++ +E+R KKY
Sbjct: 2110 TQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKY 2143
>gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]
Length = 1088
Score = 103 bits (256), Expect = 7e-22
Identities = 125/564 (22%), Positives = 245/564 (43%), Gaps = 83/564 (14%)
Query: 160 KESPVSAGNDAYVDLDRQLKK-------TTEELNEALSAKEEIAQRCHELDMQVAALQEE 212
K+S +S+ DL+ +++ +TEE E + E + ++ +++E
Sbjct: 387 KDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQE 446
Query: 213 KS----SLLAENQVLMERLNQ-SDSIEDPNSPAGRRHLQ-LQTQLEQLQEETFRLEAAKD 266
S LLA L NQ SDS ++H++ L+ L ++ L+ D
Sbjct: 447 LSRKDTELLALQTKLETLTNQFSDS---------KQHIEVLKESLTAKEQRAAILQTEVD 497
Query: 267 DYRIRCEE----LEKEISELRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVES 322
R+R EE L K+ +++ +E T A E LKD +DV KV+ L+ ++E+
Sbjct: 498 ALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKER---KVNVLQKKIEN 554
Query: 323 YKKKLED----LGDLRRQVKLLEEKNTMYMQNTVSLEEEL---------------RKANA 363
+++L D + L+ +VK L+ T +LEE L R
Sbjct: 555 LQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDERE 614
Query: 364 ARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQ----KEKDRLRTERDS 419
+ +++ YK+ + +L+ ++S + + LKE SL K+ RL+T +
Sbjct: 615 KQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIA 674
Query: 420 LKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLA-AEIVTPEIREKLIRLQHE-NKML 477
L++ EE +++Q + L S E SD + E +++ + Q E +++L
Sbjct: 675 LEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLL 734
Query: 478 KL-----NQEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQ 532
++ N++ ++KIA L+ + D N + L+ + ++ ++ ++ + + +L
Sbjct: 735 EILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLN 794
Query: 533 DQGSKAEDSVLLKK-KLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALR 591
D + +DS+ K ++EE E L E+ ++ ++ E N+ ++EEL A+
Sbjct: 795 DSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAME 854
Query: 592 KKEEEMKQMEERYKK---------------YLEKAKSVIRTLDPKQNQGAAPEIQALKNQ 636
K ++E++ M+ + E+ K + L+ KQ +AL
Sbjct: 855 KVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQ--------EALLAA 906
Query: 637 LQERDRLFHSLEKEYEKTKSQREM 660
+ E+D LE K K+Q E+
Sbjct: 907 ISEKDANIALLELSSSKKKTQEEV 930
Score = 76.6 bits (187), Expect = 7e-14
Identities = 105/441 (23%), Positives = 195/441 (44%), Gaps = 70/441 (15%)
Query: 282 LRQQNDELTTLADEAQSLKD---EIDVLRHSSD-KVSKLEGQVESYKK----KLEDLGDL 333
LRQ D T+ D LK+ E D+LR + K SKL + S K +L+ L
Sbjct: 143 LRQARDN--TIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERAL 200
Query: 334 RR-----------QVKLLEEKNTMYMQNTV-SLEEELRKANAAR------SQLETYKRQV 375
R+ Q ++++E+N +MQ T+ +L++ELR S T + V
Sbjct: 201 RKDEASKITIWKEQYRVVQEEN-QHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCV 259
Query: 376 VEL-----QNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRLRTERDSLKETIEELRCV 430
EL Q +E ++A +L K L+E ++ +K L +S+K+ +E L+
Sbjct: 260 AELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQ-- 317
Query: 431 QAQEGQLTTQGLMPLGSQESSDSLA----AEIVTPEIREKLIRLQHENKMLKLN-----Q 481
++GL ++E + AE+ + L + + EN ML+ +
Sbjct: 318 --------SKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFE 369
Query: 482 EGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQ----VEELQKSLQDQGSK 537
D+ K LQ++++ + + + +E R + + + ++S EE ++ ++
Sbjct: 370 NAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVY 429
Query: 538 AEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEEM 597
S +K K+ + ++L + EL + +E L +F++S IE L+E+L KE+
Sbjct: 430 RSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRA 489
Query: 598 K-----------QMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRLFHS 646
++EE+ +K K + + K Q A EI LK+ L ++R +
Sbjct: 490 AILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQ--AGEIHDLKDMLDVKERKVNV 547
Query: 647 LEKEYEKTKSQREMEEKYIVS 667
L+K+ E + Q +EK + S
Sbjct: 548 LQKKIENLQEQLRDKEKQMSS 568
Score = 71.6 bits (174), Expect = 2e-12
Identities = 105/498 (21%), Positives = 227/498 (45%), Gaps = 50/498 (10%)
Query: 203 DMQVAALQEEKSSLLAENQVLME--RLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFR 260
D + LQ + +L EN +L + + +S NS +L+ + ++E +
Sbjct: 148 DNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASK 207
Query: 261 LEAAKDDYRIRCEE-------LEKEISELRQQNDELTTLADEAQSLKDEIDVLRHSSDKV 313
+ K+ YR+ EE ++ ELR Q D ++ S E V + +
Sbjct: 208 ITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENF 267
Query: 314 SKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRK--------ANAAR 365
+L + ++++ ++L LR+ ++ +E + Q + +E ++K +A+
Sbjct: 268 QRLHAE---HERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAK 324
Query: 366 SQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRLRTERDSLKETIE 425
+ E ++R RL+E L+ ++ KEK +S+ +E+ R E +
Sbjct: 325 ATEEDHERT-----RRLAEAEMHVHHLESLLEQ-KEKENSMLREEMHRRFENAPDSAKTK 378
Query: 426 ELRCV-QAQEGQLTT--QGLMPLGSQ----ESSDSLAAEIVTPEIREKLIRLQH----EN 474
L+ V + ++ ++++ +GL L + +S+ +L+ E E+++ + H +N
Sbjct: 379 ALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKN 438
Query: 475 KMLKLNQEGS--DNEKIAL---LQSLLDDANLRKNELETENRLVN---QRLLEVQSQVEE 526
K+ ++ QE S D E +AL L++L + + K +E + QR +Q++V+
Sbjct: 439 KIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDA 498
Query: 527 LQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEEL 586
L+ L+++ + K++++ E+ E+ + +++ E + N KIE L
Sbjct: 499 LRLRLEEKETMLNKKT---KQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENL 555
Query: 587 QEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRLFHS 646
QE LR KE++M ++ER K L+ + T + A + + ++ ++RDR
Sbjct: 556 QEQLRDKEKQMSSLKERVKS-LQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDERE 614
Query: 647 LEKEYEKTKSQ-REMEEK 663
++E + K ++++EK
Sbjct: 615 KQEEIDNYKKDLKDLKEK 632
Score = 60.5 bits (145), Expect = 5e-09
Identities = 94/437 (21%), Positives = 183/437 (41%), Gaps = 62/437 (14%)
Query: 157 LMSKESPVSAGNDAYVDLDRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSL 216
L + E + + + ++ QLKK E EA A E++ R L+ ++ ++E S
Sbjct: 668 LKTLEIALEQKKEECLKMESQLKKAHEAALEA-RASPEMSDRIQHLEREITRYKDESSKA 726
Query: 217 LAENQVLMERLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELE 276
AE L+E L + +E+ + ++ +L+ Q++ ++ L K ++ ++
Sbjct: 727 QAEVDRLLEILKE---VENEKNDKDKKIAELERQVKDQNKKVANL---KHKEQVEKKKSA 780
Query: 277 KEISELRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLE-----------------GQ 319
+ + E R++ D L D +Q L+D LR D++ +LE Q
Sbjct: 781 QMLEEARRREDNLN---DSSQQLQDS---LRKKDDRIEELEEALRESVQITAEREMVLAQ 834
Query: 320 VESYK----KKLEDLGDLRRQVKL-LEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQ 374
ES + K++E+L +VK LE SL E+ R++ + +
Sbjct: 835 EESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEE 894
Query: 375 VVELQNR-----LSEESKKADKLDFEY--KRLKEKVDSLQKEKDRLRTERDSLKETIEEL 427
V+E++ +SE+ L+ K+ +E+V +L++EKDRL + + +L
Sbjct: 895 VLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKL 954
Query: 428 RCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLK-----LNQE 482
++ + + S D +I + L+ L LK L
Sbjct: 955 MADNYEDDHFKSSHSNQTNHKPSPD---------QIIQPLLELDQNRSKLKLYIGHLTTL 1005
Query: 483 GSDNEKIALLQSLLDDA--NLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAED 540
D + + +L+ L A NL ++ EN L Q++ Q Q +EL+K +D E
Sbjct: 1006 CHDRDPL-ILRGLTPPASYNLDDDQAAWENEL--QKMTRGQLQ-DELEKGERDNAELQEF 1061
Query: 541 SVLLKKKLEEHLEKLHE 557
+ + +++ +H + E
Sbjct: 1062 ANAILQQIADHCPDILE 1078
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 103 bits (256), Expect = 7e-22
Identities = 141/638 (22%), Positives = 270/638 (42%), Gaps = 74/638 (11%)
Query: 96 NDFTLPDVNLIGEHSD-AAELGRMLQLILGCAVNCEQKQEYIQAIMMMEESVQHVVMTAI 154
+D D+N+ + ++ EL + +L+ E E + ++ + +Q V +
Sbjct: 1801 SDMPRNDINMWSKVTEEGTELSQ--RLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLL 1858
Query: 155 QELMSKESPVSAGNDAYVDLDRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKS 214
+ + S + +L R+ + +E E+L +EE+ +R HE L E S
Sbjct: 1859 EAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELS 1918
Query: 215 SL------LAENQVLMERLNQS-----DSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEA 263
A+ + L ER Q D +E A R +L+ + +Q+QEE L
Sbjct: 1919 KAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSR 1978
Query: 264 AKDDYRIRCEELEKE-ISELRQQNDELTTLADEAQSLKDEI--DVLRHSSDKVSKLEGQV 320
K+ + +E++ + E + E + +A+ ++D++ V D ++ +
Sbjct: 1979 QKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFI 2038
Query: 321 ESYKKKLEDLGDLRRQVKLLE---EKNTMYM-QNTVSLEEELRKANAARSQLETYKRQVV 376
E ++K +L DLR+Q + LE EK ++ + + E E +LE + V
Sbjct: 2039 ELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVP 2098
Query: 377 ELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRLRTERDSLKETIEELRC-VQAQEG 435
Q ++++ ++L K +K L K++L+ + E IE+L V+ E
Sbjct: 2099 RFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQ 2158
Query: 436 QLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQE------GSDNEKI 489
L + G+ E+ L+ E+ R+ + R + E L+ E + NE++
Sbjct: 2159 ALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEV 2218
Query: 490 ALLQSLLD----DANLRKNELETENRLVNQRLLEVQSQVEELQ-KSLQDQ----GSKAED 540
L L+ ++ R ELE EN+L + ++ ++E S QDQ G A+
Sbjct: 2219 QQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQ- 2277
Query: 541 SVLLKKKLE-----EHLEKLHEA------NNELQKKRAIIEDLEPRF-----------NN 578
++ +K++E E + KL + N +++K +I DLE + N
Sbjct: 2278 -IIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRN 2336
Query: 579 SSLKIEELQEALRKKEEEMKQMEERYK----KYLEKAKSVIRTLD---------PKQNQG 625
+IE+L E + K ++E+ + ++ E+A S+ LD +Q +
Sbjct: 2337 REEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVET 2396
Query: 626 AAPEIQALKNQLQERDRLFHSLEKEYEKTKSQREMEEK 663
A E+ +KN L+E + + L +E K +RE EK
Sbjct: 2397 ANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEK 2434
Score = 100 bits (248), Expect = 6e-21
Identities = 116/533 (21%), Positives = 246/533 (46%), Gaps = 62/533 (11%)
Query: 168 NDAYVDLDRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERL 227
+D+Y + Q T E+ E+ E+A + HE++ L+E + + E ++
Sbjct: 142 DDSYSEQGAQDSPTHLEMMES-----ELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEF 196
Query: 228 NQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFR--LEAAKDDYRIRCEELEKEISELRQQ 285
+ D +LQ Q + ++ET R LE + +++ + + + SE +
Sbjct: 197 EAAIKQRDGIITQLTANLQ---QARREKDETMREFLELTEQSQKLQIQFQQLQASETLRN 253
Query: 286 NDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNT 345
+ +T AD Q+ + +L H ++ + + +E Y+KK ED Q+ L+EK
Sbjct: 254 STHSSTAADLLQAKQQ---ILTHQQ-QLEEQDHLLEDYQKKKEDF---TMQISFLQEKIK 306
Query: 346 MYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKK----------ADKL--- 392
+Y +E++ + N+ + +++ + + EL ++ EE KK ADKL
Sbjct: 307 VY-----EMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGE 361
Query: 393 --------DFEYKRLKEKVDSLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGL-- 442
+ E K +K ++ + ++++ + E L T+EEL+ ++ Q T +
Sbjct: 362 LQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQR 421
Query: 443 MPLGSQESSDSLAAEI------VTPEIREKLIRLQHENKMLKLNQEGSDNEKIALLQSLL 496
M +Q + L AE+ +++++LIR QH +M +E K + +L
Sbjct: 422 MEQETQRKLEQLRAELDEMYGQQIVQMKQELIR-QHMAQM----EEMKTRHKGEMENALR 476
Query: 497 DDANLRKNE--LETENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEK 554
+N+ NE ++ N +N+ +++Q + +K ++ G E+ L+++LE+ +E+
Sbjct: 477 SYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEE 536
Query: 555 LHEANNELQKKRAIIEDLEPRFN---NSSLKIEELQEALRKKEEEMKQMEERYKKYLEKA 611
L + ++Q+ R I + E + N S +E+L+ + E K++E +++ +
Sbjct: 537 LSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNY 596
Query: 612 KSVIRTLDPKQNQGAAPEIQALKNQLQE-RDRLFHSLEKEYEKTKSQREMEEK 663
K + L+ ++N ++ + +L+ R +L S E+E K K E+E +
Sbjct: 597 KIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHR 649
Score = 83.6 bits (205), Expect = 6e-16
Identities = 133/562 (23%), Positives = 242/562 (43%), Gaps = 65/562 (11%)
Query: 130 EQKQEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELNEAL 189
E K E +Q + M E + T +QEL + N + D +L +E ++A+
Sbjct: 2212 ENKNEEVQQLHMQLEIQKKESTTRLQELEQE-------NKLFKDDMEKLGLAIKE-SDAM 2263
Query: 190 SAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSDSIEDPNSPAGRRH---LQ 246
S +++ H L + A + +EK + + + +L Q I N ++
Sbjct: 2264 STQDQ-----HVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRD 2318
Query: 247 LQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADE----AQSLKDE 302
L+TQ+E L + E K + E+L + I +L+Q EL + + A SL +E
Sbjct: 2319 LETQIECLMSDQ---ECVKRNREEEIEQLNEVIEKLQQ---ELANIGQKTSMNAHSLSEE 2372
Query: 303 IDVLRHSSDKVSK----LEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEEL 358
D L+H D V LE QVE+ +++ + ++ ++ + T + + E +
Sbjct: 2373 ADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESV 2432
Query: 359 RKA-----NAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKE--KVDSLQKEKD 411
K N+ ++ + EL+ L+E++ K+ + +K +E K + E
Sbjct: 2433 EKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETR 2492
Query: 412 RLRTERDSLKETIEELRCVQA-----QEGQLTTQGLMP--LGSQESSDSLAAEIVTPEIR 464
L+ E + +E +C + ++GQ T+ L + Q+ + A + +I+
Sbjct: 2493 LLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQ 2552
Query: 465 EKLIRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQV 524
L +Q K + NQ S + +Q+L LR++EL ++ + R+ E++SQV
Sbjct: 2553 --LEAVQEYAKFCQDNQTISSEPERTNIQNL---NQLREDELGSDISALTLRISELESQV 2607
Query: 525 EELQKSL---QDQGSKAEDSVLLKKKLEEHLEKLHEANNELQK---KRAIIEDLEP---- 574
E+ SL ++Q AE +VL K+K L+KL E N + Q+ K+ +D+E
Sbjct: 2608 VEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTT 2667
Query: 575 ----RFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEI 630
N S EL EALR + K YK+ EK + + + ++
Sbjct: 2668 TELFHSNEESGFFNEL-EALRAESVATKAELASYKEKAEKLQEELLVKETNMT-SLQKDL 2725
Query: 631 QALKNQLQERDRLFHSLEKEYE 652
+++ L E LEKE E
Sbjct: 2726 SQVRDHLAEAKEKLSILEKEDE 2747
Score = 82.4 bits (202), Expect = 1e-15
Identities = 124/577 (21%), Positives = 246/577 (42%), Gaps = 58/577 (10%)
Query: 130 EQKQEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELNEAL 189
+ KQE I+ M E ++ ++ + S ++ D Q+K +NE
Sbjct: 447 QMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNED-------QIKLMNVAINELN 499
Query: 190 SAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSDSIEDPNSPAGRRHLQLQT 249
++ + +L ++ + EEK +L + + L+E L+ S Q+Q
Sbjct: 500 IKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSRE-------------QIQR 546
Query: 250 QLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEAQSLKDEIDVLRHS 309
+ + E+ +L A E+L+ EI + EL L EA+ +I +
Sbjct: 547 ARQTIAEQESKLNEAHKSLS-TVEDLKAEIVSASESRKEL-ELKHEAEVTNYKIKLEMLE 604
Query: 310 SDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAARSQLE 369
+K + L+ ES + +LE LR Q+ E+ ++ + +E + +
Sbjct: 605 KEKNAVLDRMAESQEAELE---RLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGI 661
Query: 370 TYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRLRTERDSLKETIEELRC 429
YK+Q+ LQN E S+K + + FE L K + L E +L+ + SL + E
Sbjct: 662 HYKQQIDGLQN---EMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMT 718
Query: 430 VQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSDNEKI 489
+Q E Q + L ++ +L E+ +++ +L+ Q + K E EK
Sbjct: 719 LQINELQKEIEILRQ--EEKEKGTLEQEVQELQLKTELLEKQMKEK------ENDLQEKF 770
Query: 490 ALLQSLLDDANLRKNELETENRLVNQRLLEVQSQV--EELQKSLQDQGSKAEDSV----- 542
A L++ +N + + + + +L++ + V EE L SK++DSV
Sbjct: 771 AQLEA--------ENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEI 822
Query: 543 -LLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQME 601
+L ++ E+ ++ + N E++K+R E F + +++E L K +++++ +
Sbjct: 823 EILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLE--D 880
Query: 602 ERYKKYLEKAKSVIRTLDPKQN-QGAAPEIQALKNQLQERDRLF--HSLEKEYEKTKSQR 658
+ K+ LE KS ++ L+ + + Q P +K+ + + D+ F +LE K
Sbjct: 881 SKNKQELE-YKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTT 939
Query: 659 EMEEKYIVSAWYNMGMTLHKKAAEDRLASTGSGQSFL 695
E+ EK V+ + ++ ++L SFL
Sbjct: 940 ELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFL 976
Score = 72.8 bits (177), Expect = 1e-12
Identities = 135/621 (21%), Positives = 275/621 (44%), Gaps = 89/621 (14%)
Query: 34 DLTNGVVMAQVLQKIDPAYFD------ENWLNRIKTEVGDNWRLKISNLKKILKGILDYN 87
++TN + ++L+K A D E L R++T++ + ++S LK+ L +
Sbjct: 592 EVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDL----EIE 647
Query: 88 HEILGQQINDFTLPDVNLIGEHSDAAELGRMLQLILGCAVNCEQKQEYIQAIMMMEESVQ 147
H I +++ D +G H Q I G QK E +Q + Q
Sbjct: 648 HRINIEKLKDN-------LGIHYK--------QQIDGLQNEMSQKIETMQFEKDNLITKQ 692
Query: 148 HVVMTAIQELMS-KESPVSAGNDAYVDLDRQLKKTTEELNEALSAKEEIAQRCHELDMQV 206
+ ++ I +L ++S V++ ++ +L+K E L + K + Q EL ++
Sbjct: 693 NQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKT 752
Query: 207 AAL-----------QEEKSSLLAENQVLMERLNQSDSIEDPNSPAGRRH-------LQLQ 248
L QE+ + L AEN +L + + + ++P + ++ +
Sbjct: 753 ELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSK 812
Query: 249 TQLEQLQEETFRLEAAKDDYRIRCEELEKEISELR------QQNDELTTLADEAQSLKDE 302
++ ++E L +D + +C +L +EI + R ++N E+ Q L++E
Sbjct: 813 SKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNY-----QELQEE 867
Query: 303 IDVLRHSSDKVSKLEGQVE-SYKKKLEDLGD-----------LRRQVKLLEEKNTMYMQN 350
L D + + + E YK KL+ L + ++ + + +E T ++
Sbjct: 868 YACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKT-FVAE 926
Query: 351 TVSLEEELRK-ANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKE 409
T+ + E + K +LE KR+ +EL RLS+ S++ + E L E+V SL++E
Sbjct: 927 TLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQE 986
Query: 410 KDRLRTERDSLKETIEELRC--VQAQEGQLTT--QGLMPLGSQESSDSLAAEIVTPEIRE 465
K+++ L+ I R VQ+ + Q+++ G++ + S+ + S++ V E
Sbjct: 987 KEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSK--VNKSFGE 1044
Query: 466 KLIRLQHENKMLKLNQ---EGSDNEKIAL--LQSLLDDANLRKNELETENRLVNQRLLEV 520
+ ++ E+K+ N E S E++ L L S+ +++LR + +EN + + L +
Sbjct: 1045 E-SKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQ-PSENDKLQKELNVL 1102
Query: 521 QSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSS 580
+S+ +L+ ++ Q + L H++++ E E +K +A+ E
Sbjct: 1103 KSEQNDLRLQMEAQ------RICLSLVYSTHVDQVRE-YMENEKDKALCSLKEELIFAQE 1155
Query: 581 LKIEELQEALRKKEEEMKQME 601
KI+ELQ+ + + + MK E
Sbjct: 1156 EKIKELQKIHQLELQTMKTQE 1176
Score = 70.1 bits (170), Expect = 7e-12
Identities = 100/480 (20%), Positives = 210/480 (43%), Gaps = 57/480 (11%)
Query: 246 QLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEAQS-LKDEID 304
+LQ +E+L E + + ++ EL +E +Q+ E +E + L +E
Sbjct: 1849 RLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESR 1908
Query: 305 VLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVS-LEEELRKANA 363
+ ++SK EG ++ Y + K L E+ + + LE+EL A+
Sbjct: 1909 AREQLAVELSKAEGVIDGYADE-----------KTLFERQIQEKTDIIDRLEQELLCASN 1957
Query: 364 ARSQLETYKRQVVELQNRLS--EESKKADKLDFEYKRLKEKVDSLQKEKDRLRTE----R 417
+LE ++Q+ E + LS +E+ KA+ E + L+E + L KEK ++ + R
Sbjct: 1958 RLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQE-TEKLMKEKLEVQCQAEKVR 2016
Query: 418 DSLKETIEEL---------RCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLI 468
D L++ ++ L R ++ ++ + T LM L Q + E + + E+ I
Sbjct: 2017 DDLQKQVKALEIDVEEQVSRFIELEQEKNTE--LMDLRQQNQALEKQLEKMRKFLDEQAI 2074
Query: 469 RLQHENKMLKLNQEGSDNEK--IALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEE 526
+HE + + + + + + Q + + +L + + E+ E+
Sbjct: 2075 DREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQ 2134
Query: 527 LQKSLQDQGSKAEDSVLLKKKLEEHL---EKLH----EANNEL------QKKRAIIEDLE 573
LQ+ +Q++ + E ++LE+ L ++ H EA EL Q +R I+ E
Sbjct: 2135 LQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKE 2194
Query: 574 PRFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQ-NQGAAPEIQA 632
N ++E+ +E L K EE++Q+ + + ++K +S R + +Q N+ +++
Sbjct: 2195 KEITNLEEQLEQFREELENKNEEVQQLHMQLE--IQKKESTTRLQELEQENKLFKDDMEK 2252
Query: 633 LKNQLQERDRLF----HSLEKEYEKTKSQREME----EKYIVSAWYNMGMTLHKKAAEDR 684
L ++E D + H L ++ + ++E+E + + + +T K E++
Sbjct: 2253 LGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEK 2312
Score = 68.6 bits (166), Expect = 2e-11
Identities = 81/410 (19%), Positives = 193/410 (47%), Gaps = 53/410 (12%)
Query: 297 QSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEE 356
+++ + L H+ KV++ E ES+++K E L+ Q +L E + + + + E+
Sbjct: 1859 EAISETSSQLEHA--KVTQTELMRESFRQKQEATESLKCQEELRERLH----EESRAREQ 1912
Query: 357 ELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRLRTE 416
+ + A ++ Y + + ++ E++ D+L+ E ++ L+ E+ +++ E
Sbjct: 1913 LAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEE 1972
Query: 417 RDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIR--LQHEN 474
R+ L E ++ A+ G + Q L + ++ L E + + + + +R LQ +
Sbjct: 1973 RELLSRQKEAMK---AEAGPVEQQLL------QETEKLMKEKLEVQCQAEKVRDDLQKQV 2023
Query: 475 KMLKLNQEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQ 534
K L+++ E E+++ L + N +L +N+ ++ Q+E+++K L +Q
Sbjct: 2024 KALEIDVE----EQVSRFIELEQEKNTELMDLRQQNQ-------ALEKQLEKMRKFLDEQ 2072
Query: 535 GSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIE----DLEPRFNNSSLKIEELQEAL 590
E + ++ ++KL + + + + I E ++E N+ K ++ E L
Sbjct: 2073 AIDREHE---RDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELL 2129
Query: 591 RKKEEEMKQMEERYKKYLEKAKSVIRTL------DPKQNQGAAP---------EIQALKN 635
KE+ + ++ER ++ +EK + +R L + +++ GA ++QA ++
Sbjct: 2130 LSKEQLQRDIQERNEE-IEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERD 2188
Query: 636 QLQERDRLFHSLEKEYEKTKSQREMEEKYIVSAWYNMGMTLHKKAAEDRL 685
+ +++ +LE++ E+ + E+E K +M + + KK + RL
Sbjct: 2189 AIDRKEKEITNLEEQLEQFR--EELENKNEEVQQLHMQLEIQKKESTTRL 2236
Score = 65.1 bits (157), Expect = 2e-10
Identities = 129/639 (20%), Positives = 247/639 (38%), Gaps = 81/639 (12%)
Query: 83 ILDYNHEILGQQINDFTLPDVNLIGEHSDAAELGRMLQLILGCAVNCEQKQEYIQAIMMM 142
+L+YN + Q+ + V L A EL QL V E K E Q + +
Sbjct: 3113 LLEYN---IQQKQSQMLEMQVELSSMKDRATELQE--QLSSEKMVVAELKSELAQTKLEL 3167
Query: 143 EESV--QHVVMTAIQ----ELMSKESPVSAGNDAYVDLDRQLKKTTEELNEALSAKEEIA 196
E ++ QH + ++ E+ K V ND +K + EL AL ++
Sbjct: 3168 ETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASE----QKKSRELQWALEKEKAKL 3223
Query: 197 QRCHELDMQVAALQEEKSSLLAENQ------VLMERLNQSDSIEDPNSPAGRRHLQLQTQ 250
R E D + L++ K SL ++ Q +L+E+ Q + + + + Q
Sbjct: 3224 GRSEERDKE--ELEDLKFSLESQKQRNLQLNLLLEQ--QKQLLNESQQKIESQRMLYDAQ 3279
Query: 251 LEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEAQS---------LKD 301
L + Q L+ + ++R E+ + R+ + +L + QS LK+
Sbjct: 3280 LSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKE 3339
Query: 302 EIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKA 361
L ++ +L + E YK L+ L Q + EK+ + T+ E+E
Sbjct: 3340 LQKQLEEKHSRIVELLNETEKYK--LDSL-----QTRQQMEKDRQVHRKTLQTEQEAN-- 3390
Query: 362 NAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQK---EKDRLRTERD 418
+ ++ + +V +LQ +L E+ ++ KLD E +RL+ + QK E++ R R
Sbjct: 3391 TEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRR 3450
Query: 419 SLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPE------------IREK 466
L + + E + L E+ +S A+++ IR+K
Sbjct: 3451 ILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQK 3510
Query: 467 L------IRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEV 520
L +++ + +L E +D+E +Q +D+ L+ Q+L
Sbjct: 3511 LQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQL-----------QKLTGQ 3559
Query: 521 QSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSS 580
Q + L GS E + +L H+ +L E N+L+ +E+ + +
Sbjct: 3560 QGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTG 3619
Query: 581 LKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQER 640
+ ++ + K+ + K ++ K + A E+ LK +L+
Sbjct: 3620 AGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQ----KSLKRAEAEVYKLKAELR-N 3674
Query: 641 DRLFHSLEKEYEKTKSQREMEEKYIVSAWYNMGMTLHKK 679
D L +L + E +R + KY+ + + + KK
Sbjct: 3675 DSLLQTLSPDSEHVTLKR-IYGKYLRAESFRKALIYQKK 3712
Score = 57.4 bits (137), Expect = 5e-08
Identities = 108/521 (20%), Positives = 208/521 (39%), Gaps = 97/521 (18%)
Query: 142 MEESVQHVVMTAIQELMS-KESPVSAGNDAYVDLDRQLKKTTEELNEALSAKEEIAQRCH 200
M QHV+ +++ KE + N+ L +QLK TT+ N+ + K E+ +
Sbjct: 2263 MSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTD--NKVIEEKNELIR--- 2317
Query: 201 ELDMQVAALQEEKSSLLAENQVLMERLNQ--------------------------SDSIE 234
+L+ Q+ L ++ + + +E+LN+ +DS++
Sbjct: 2318 DLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLK 2377
Query: 235 DPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLA- 293
L L+ Q+E EE ++ + + +L +E+ L+++ + + +
Sbjct: 2378 HQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQS 2437
Query: 294 ----------DEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGD---LRRQVKLL 340
D K E++V+ + D + LE Q +Y K E+ G + + +LL
Sbjct: 2438 IPENSVNVAIDHLSKDKPELEVVL-TEDALKSLENQ--TYFKSFEENGKGSIINLETRLL 2494
Query: 341 EEKNTMYMQN---TVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYK 397
+ ++T+ ++ T ++ + + E ++++V LQ + E+ A + +
Sbjct: 2495 QLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLE 2554
Query: 398 RLKEKVDSLQKEKDRLRTERDSLKETIEELRCVQAQEGQL------TTQGLMPLGSQ--E 449
++E Q D + + I+ L Q +E +L T + L SQ E
Sbjct: 2555 AVQEYAKFCQ---DNQTISSEPERTNIQNLN--QLREDELGSDISALTLRISELESQVVE 2609
Query: 450 SSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSDNEK-------------IALLQSLL 496
SL E EI EK + L+ E K+L+L + NEK + +L++
Sbjct: 2610 MHTSLILEKEQVEIAEKNV-LEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTT 2668
Query: 497 DDANLRK-----NELET---ENRLVNQRLLEVQSQVEELQK----------SLQDQGSKA 538
+ + + NELE E+ L + + E+LQ+ SLQ S+
Sbjct: 2669 ELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQV 2728
Query: 539 EDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNS 579
D + K+ LEK E + KK + E L + + S
Sbjct: 2729 RDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKS 2769
Score = 46.6 bits (109), Expect = 8e-05
Identities = 149/728 (20%), Positives = 286/728 (39%), Gaps = 138/728 (18%)
Query: 30 QTVEDLTNGVVMAQVLQKIDPAYFDENWLNRIKTEVGDNWRLKISNLKKILKGILDYNHE 89
Q ++ L N ++ QKI+ F+++ L + ++ L+IS LK + + +++ E
Sbjct: 665 QQIDGLQN-----EMSQKIETMQFEKDNLITKQNQL----ILEISKLKDLQQSLVNSKSE 715
Query: 90 ILGQQINDFTLPDVNLIGEHSDAAELGRMLQ-LILGCAV---NCEQKQEYIQ---AIMMM 142
+ QIN+ L E + L + +Q L L + ++K+ +Q A +
Sbjct: 716 EMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEA 775
Query: 143 EESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTE-----ELNEALSAKEEIAQ 197
E S+ +++++ +PVS + + LD K+ + E+ + E++ Q
Sbjct: 776 ENSILKDEKKTLEDMLKIHTPVSQ-EERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQ 834
Query: 198 RCHELDMQVAA------------------LQEE----------------------KSSLL 217
+C +L+ ++ LQEE KS L
Sbjct: 835 QCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLK 894
Query: 218 AENQVL-MERLNQS-----DSIEDPNSPAGRRHLQLQTQLEQLQEETF-RLEAAKDDYRI 270
A N+ L ++R+N + S+ D + L++ +E+ E +LE K +
Sbjct: 895 ALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLE 954
Query: 271 RCEELEKEISELRQQNDELTTLADEAQSLKDEID-----------VLRHS-SDKVSKLEG 318
+ L +L+Q++ E++ L +E +SLK E + ++ H+ ++ V +
Sbjct: 955 LSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDT 1014
Query: 319 QVESYKKKLEDL------GDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAARSQLETYK 372
QV S + + G + + K E++ + +++ VS E + + QL
Sbjct: 1015 QVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDH 1074
Query: 373 RQVVELQNRL-SEESKKADKLDFEYKRLKEKVDSLQKEKDRLR--------TERDSLKET 423
V ++ L + + + DKL E LK + + L+ + + R T D ++E
Sbjct: 1075 LPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREY 1134
Query: 424 IEELR----------CVQAQEGQLTTQG------LMPLGSQESSDS---------LAAEI 458
+E + + AQE ++ L + +QE+ D +
Sbjct: 1135 MENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKA 1194
Query: 459 VTPEIREKLIRL-----QHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELETENRLV 513
V+ E L L ++ LK D E S +D L+ E ++
Sbjct: 1195 VSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQE 1254
Query: 514 NQRLLEVQSQVEELQKSL--QDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIED 571
N L + EE K L Q + SK KLE E L + E + + +
Sbjct: 1255 NMHTL-LNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTN 1313
Query: 572 LEPRFNNSSLKIEELQEALRKK-EEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEI 630
LE N K+ LQ+ + K EE+++++E ++ K + +QN A EI
Sbjct: 1314 LEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLK------ETEQNYEA--EI 1365
Query: 631 QALKNQLQ 638
L+ +LQ
Sbjct: 1366 HCLQKRLQ 1373
Score = 46.6 bits (109), Expect = 8e-05
Identities = 64/258 (24%), Positives = 112/258 (43%), Gaps = 35/258 (13%)
Query: 414 RTERDSLKET--IEELRCVQA--QEGQLTTQGLMPLGSQESSDSLAAEI--VTPEIREKL 467
RTE +L T + L C++ QE + Q M + SL +EI + ++ +
Sbjct: 3038 RTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRK 3097
Query: 468 IRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQ---- 523
I L+ E + K +QE LL+ + + E++ E + R E+Q Q
Sbjct: 3098 ITLKREQESEKPSQE--------LLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSE 3149
Query: 524 ---VEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSS 580
V EL+ L + E ++ K +HL++L E++ K + L +
Sbjct: 3150 KMVVAELKSELAQTKLELETTL---KAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQ 3206
Query: 581 LKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQER 640
K ELQ AL K++ ++ + EER K+ LE K + + + Q L L+++
Sbjct: 3207 KKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQ--------LNLLLEQQ 3258
Query: 641 DRLFHSLEKEYEKTKSQR 658
+L L + +K +SQR
Sbjct: 3259 KQL---LNESQQKIESQR 3273
Score = 45.1 bits (105), Expect = 2e-04
Identities = 101/417 (24%), Positives = 175/417 (41%), Gaps = 61/417 (14%)
Query: 167 GNDAYVDLDRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMER 226
G + ++L+ +L +L +SAK+ +C++ Q+ +QE+ E ++L ++
Sbjct: 2482 GKGSIINLETRLL----QLESTVSAKDLELTQCYK---QIKDMQEQGQF---ETEMLQKK 2531
Query: 227 LNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQ-Q 285
+ I + A L Q QLE +QE + +D+ I E I L Q +
Sbjct: 2532 IVNLQKIVEEKVAAA---LVSQIQLEAVQEYA---KFCQDNQTISSEPERTNIQNLNQLR 2585
Query: 286 NDEL----TTLADEAQSLKDEIDVLRHSS-----DKVSKLEGQVESYKKKLEDLGDL--- 333
DEL + L L+ ++ V H+S ++V E V +KKL +L L
Sbjct: 2586 EDELGSDISALTLRISELESQV-VEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEG 2644
Query: 334 -RRQVKLLEEKNTMYMQNTVSLEEELRKANAAR---SQLETYKRQVVELQNRLSEESKKA 389
++ + E+K + + EL +N ++LE + + V + L+ +KA
Sbjct: 2645 NEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKA 2704
Query: 390 DKLDFEYKRLKEKVDSLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLM----PL 445
+KL E + + SLQK+ ++R KE + L E Q + + M P+
Sbjct: 2705 EKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPI 2764
Query: 446 GSQESSDS-------LAAEIVTPEIREK----LIRLQHENKMLKLNQEGSD-NEKIALLQ 493
+S S +++ TP+I K I LQ E ++ + S EKI +Q
Sbjct: 2765 KLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQ 2824
Query: 494 SL-----LDDANLRKNELETENRLVNQRLLEVQSQVEE---LQKSLQDQGSKAEDSV 542
L LD + +E ET L + + VQ EE L+ +Q SK S+
Sbjct: 2825 ELHAAEILDMESRHISETET---LKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSI 2878
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 102 bits (254), Expect = 1e-21
Identities = 130/581 (22%), Positives = 256/581 (44%), Gaps = 72/581 (12%)
Query: 131 QKQEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDL---DRQLKKTTEELNE 187
Q++E I I S +V +L K P+ + ++ + +KT +EL
Sbjct: 807 QRRESIFCIQYNIRSFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKTKDEL-- 864
Query: 188 ALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSDSIEDPNSPAGRRHLQL 247
AK E ++ EL+ ++ L +EK+ L + Q E L ++ D A QL
Sbjct: 865 ---AKSEAKRK--ELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKA---KFQL 916
Query: 248 QTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELT-TLA----------DEA 296
+ +++++ E E + + +LE E SEL++ D+L TLA ++
Sbjct: 917 EAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKV 976
Query: 297 QSLKDEIDVLRHSSDKVSKLEGQV-ESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLE 355
++L +E+ L + K+++ + + E++++ L+DL +V L + + Q LE
Sbjct: 977 KNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLE 1036
Query: 356 EELRKANAARSQLETYKRQ-----------VVELQNRLSEESKKADKLDFEYKRLKEKVD 404
L + R LE KR+ +++L+N + ++ K DFEY +L+ KV+
Sbjct: 1037 SSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVE 1096
Query: 405 -------SLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGS-----QESSD 452
QK+ L+ + L+E IE R +A+ + + L +E+
Sbjct: 1097 DEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGG 1156
Query: 453 SLAAEIVTPEIRE----KLIR------LQHENKMLKLNQEGSDNEKIALLQSLLDDANLR 502
+ +I + RE KL R LQHE + L ++ +D+ +A L +D+
Sbjct: 1157 VTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADS--VAELGEQIDNLQRV 1214
Query: 503 KNELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNEL 562
K +LE E E + ++++L S++ + + + LE+ L + N E+
Sbjct: 1215 KQKLEKEKS-------EFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEI 1267
Query: 563 QKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQ 622
Q+ + +L + + + EL L +KE + Q+ + + ++ + + R L+ ++
Sbjct: 1268 QRS---LSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLE-EE 1323
Query: 623 NQGAAPEIQALKNQLQERDRLFHSLEKEYE-KTKSQREMEE 662
N+ AL++ + D L E+E E K + QR + +
Sbjct: 1324 NKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSK 1364
Score = 93.6 bits (231), Expect = 6e-19
Identities = 124/549 (22%), Positives = 233/549 (42%), Gaps = 93/549 (16%)
Query: 134 EYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELNEALSAKE 193
E I + ++++Q A+ +L ++E V++ N L++Q++ L + +
Sbjct: 988 ETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRV 1047
Query: 194 EIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSDSIEDPNSPAGRRHLQLQTQLEQ 253
++ + +L+ + QE L + Q L ERL + D + QLQ+++E
Sbjct: 1048 DLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDF----------EYCQLQSKVED 1097
Query: 254 LQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEAQSLKDEIDVLRHSSDKV 313
Q + + + + R EELE+EI R A A++ K D R
Sbjct: 1098 EQTLGLQFQKKIKELQARIEELEEEIEAER---------ATRAKTEKQRSDYAR------ 1142
Query: 314 SKLEGQVESYKKKLEDLGDLRR-QVKLLEEKNTMYMQNTVSLEEELRKANAARSQLETYK 372
++E ++LE+ G + Q++L +++ +++ LEE + A + L
Sbjct: 1143 -----ELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALR--- 1194
Query: 373 RQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRLRTERDSLKETIEELRCVQA 432
K AD + L E++D+LQ+ K +L E+ K I++L
Sbjct: 1195 -------------KKHADSV----AELGEQIDNLQRVKQKLEKEKSEFKLEIDDLS---- 1233
Query: 433 QEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSDNEKIALL 492
S ES A + EK+ R + +L++ NE+I
Sbjct: 1234 -------------SSMESVSKSKANL------EKICRTLED----QLSEARGKNEEI--- 1267
Query: 493 QSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHL 552
Q L + +K+ L+TE ++++L E +S V +L +S Q + E+ LK++LEE
Sbjct: 1268 QRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEE---LKRQLEEEN 1324
Query: 553 EKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLEKAK 612
+ + + LQ R + L ++ ELQ AL K E+ Q +Y +
Sbjct: 1325 KAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKY-----ETD 1379
Query: 613 SVIRTLDPKQ-NQGAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQREMEEKYI-VSAWY 670
++ RT + ++ + A +Q + Q++ + SLEK K + Q E+E+ + V
Sbjct: 1380 AIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEK--TKQRLQGEVEDLMVDVERAN 1437
Query: 671 NMGMTLHKK 679
++ L KK
Sbjct: 1438 SLAAALDKK 1446
Score = 93.6 bits (231), Expect = 6e-19
Identities = 142/585 (24%), Positives = 254/585 (43%), Gaps = 97/585 (16%)
Query: 182 TEELNEALSAKEEIAQRCHELDMQV-------AALQEEKSSLLAENQVLMERLNQSDSIE 234
TEEL EA K+++AQR + + QV A+L++ K L E + LM + +++S+
Sbjct: 1384 TEELEEA---KKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLA 1440
Query: 235 DPNSPAGRRH----LQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELT 290
R + +T+ E+ Q E LEA+ + R EL K + + D+L
Sbjct: 1441 AALDKKQRNFDKVLAEWKTKCEESQAE---LEASLKESRSLSTELFKLKNAYEEALDQLE 1497
Query: 291 TLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQN 350
T+ E ++L+ EI L + K ++E +K++E LE+ +
Sbjct: 1498 TVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIE-----------LEKADIQLALE 1546
Query: 351 TVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEK 410
E +A R QLE + + E+ +++E+ ++ ++L Y+R E + S +
Sbjct: 1547 EAEAALEHEEAKILRIQLELTQVK-SEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAE 1605
Query: 411 DRLRTERDSLK----------------------ETIEELRCVQAQ--EGQLTTQGLMPLG 446
R R E LK ET++ LR VQ Q + QL + G
Sbjct: 1606 VRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDAL-RG 1664
Query: 447 SQESSDSLA-----AEIVTPEIREKLIRLQHENKMLKLNQEG--SDNEKIALLQSLLDDA 499
++ + LA A ++ E+ E L+ + KL ++ NE++ LL +
Sbjct: 1665 QEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSL 1724
Query: 500 NLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEAN 559
K +LET+ L+++QS+VE+ + ++ KA+ ++ + E L+K + +
Sbjct: 1725 IHTKKKLETD-------LMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTS 1777
Query: 560 NELQKKRAIIE----DLEPRFNNS--------SLKIEELQEALRKKEEEMKQMEERYKKY 607
L++ + +E DL+ R + + +I++L+ +R+ E E +E KK
Sbjct: 1778 AHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFE---LEGEQKKN 1834
Query: 608 LEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQREMEEKYIVS 667
E K +R + + + + KN L RL ++K K KS + E+
Sbjct: 1835 TESVKG-LRKYERRVKELTYQSEEDRKNVL----RLQDLVDKLQVKVKSYKRQAEEADEQ 1889
Query: 668 AWYNMGMTLHKKA------AEDRLASTGSGQSFL-ARQRQATSSR 705
A N +T +KA AE+R S + L A+ R TSSR
Sbjct: 1890 A--NAHLTKFRKAQHELEEAEERADIAESQVNKLRAKTRDFTSSR 1932
Score = 92.4 bits (228), Expect = 1e-18
Identities = 135/599 (22%), Positives = 252/599 (42%), Gaps = 81/599 (13%)
Query: 130 EQKQEYIQAIMMMEESVQHVVMTAIQELMSKESPVSA---GNDAYVDLDRQLKKTTEELN 186
E+ Q + + + +Q ++L KES VS A+ +LK+ EE N
Sbjct: 1265 EEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEEN 1324
Query: 187 EALSAKEEIAQRC-HELDMQVAALQEEKSSLLAENQVLMERLNQSDSI--EDPNSPAGRR 243
+A +A Q H+ D+ +EE+ AE Q + + N + + A +R
Sbjct: 1325 KAKNALAHALQSSRHDCDLLREQYEEEQEGK-AELQRALSKANSEVAQWRTKYETDAIQR 1383
Query: 244 HLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEAQSLKDEI 303
+L+ ++L + E + +C LEK L+ + ++L + A SL +
Sbjct: 1384 TEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAAL 1443
Query: 304 DVLRHSSDKV------------SKLEGQVE--------------SYKKKLEDLGDLRRQV 337
D + + DKV ++LE ++ +Y++ L+ L ++R+
Sbjct: 1444 DKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKREN 1503
Query: 338 KLLEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQV----VELQNRLSEESKKADKLD 393
K LE++ + + + + +R Q+E K + E + L E K ++
Sbjct: 1504 KNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQ 1563
Query: 394 FEYKRLKEKVDSLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDS 453
E ++K ++D EKD E + LK + R V+ + L + + S+ +
Sbjct: 1564 LELTQVKSEIDRKIAEKDE---EIEQLKRNYQ--RTVETMQSALDAE----VRSRNEAIR 1614
Query: 454 LAAEIVTPEIREKLIRLQHENKML--KLNQEGSDNEKIALLQSLLDDANLRKNELETENR 511
L + + ++ E I+L H N+ L S ++ Q LDDA + +L+ +
Sbjct: 1615 LKKK-MEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLA 1673
Query: 512 LVNQRLLEVQSQVEELQKSLQ--DQGSKAEDSVLL-------------------KKKLEE 550
+V +R +Q++VEEL+ +L+ ++ K + LL KKKLE
Sbjct: 1674 IVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLET 1733
Query: 551 HLEKLH-EANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLE 609
L +L E + + R E + ++++ EEL KKE++ ER KK LE
Sbjct: 1734 DLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEEL-----KKEQDTSAHLERMKKNLE 1788
Query: 610 K-AKSVIRTLDPKQN---QGAAPEIQALKNQLQERD-RLFHSLEKEYEKTKSQREMEEK 663
+ K + LD + +G +IQ L+ +++E + L +K E K R+ E +
Sbjct: 1789 QTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERR 1847
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 102 bits (254), Expect = 1e-21
Identities = 131/585 (22%), Positives = 252/585 (43%), Gaps = 82/585 (14%)
Query: 159 SKESPVSAGNDAYVDLDRQLKKTTEELN---EALSAKEEIAQRCHELDMQVAALQEEKSS 215
+KE A N+ +L+++ + TEE N E L A+ E+ E+ +++AA ++E
Sbjct: 864 TKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEE 922
Query: 216 LLAENQV-LMERLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEE 274
+L E + L E ++ ++ ++ L L+ QLE+ + +L+ K + ++
Sbjct: 923 ILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKK 982
Query: 275 LEKEISELRQQNDEL---------------TTLADEAQSLKDEIDVLRHSSDKVSKLE-- 317
LE EI + QN++L T LA+E + K+ + +S+LE
Sbjct: 983 LEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR 1042
Query: 318 --------GQVESYKKKLE-DLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAAR--- 365
++E K+KLE D D Q+ L+ + EEEL+ A A
Sbjct: 1043 LKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDE 1102
Query: 366 -SQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRLRTE-RDSLKET 423
+Q +++ EL+ +S+ + D + +++ L +E + L+TE D+L T
Sbjct: 1103 IAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDST 1162
Query: 424 I--EELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQ 481
+ELR + QE + + L ++ + E E+R+K H + +L +
Sbjct: 1163 ATQQELRAKREQEVTVLKKAL-------DEETRSHEAQVQEMRQK-----HAQAVEELTE 1210
Query: 482 EGSDNEKIALLQSLLDDANLRKNE--LETEN-------RLVNQRLLEVQSQVEELQKSLQ 532
+ L Q ANL KN+ LE EN R++ Q EV+ + ++L+ +Q
Sbjct: 1211 Q--------LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQ 1262
Query: 533 DQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPR-------FNNSSLKIEE 585
+ SK D + +L +K+H+ NE++ ++ + E + + S ++++
Sbjct: 1263 ELQSKCSDGERARAELN---DKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD 1319
Query: 586 LQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQ--NQGAAPEIQALKNQLQERDRL 643
QE L+++ + + + ++ E+ S+ LD + Q I L QL + +
Sbjct: 1320 TQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKK 1379
Query: 644 FHSLEKEYEKTKSQREMEEKYIVSAWYNMGMTLHKKAAEDRLAST 688
E + ++ +K I + K AA D+L T
Sbjct: 1380 LQDFASTVEALEEGKKRFQKEIENLTQQYE---EKAAAYDKLEKT 1421
Score = 97.8 bits (242), Expect = 3e-20
Identities = 142/633 (22%), Positives = 271/633 (42%), Gaps = 83/633 (13%)
Query: 84 LDYNHEILGQQINDFTLPDVNLIGEHSDAAELGRMLQ----LILGCAVNCEQKQEYIQAI 139
L ++L ++I+D T NL E A L ++ +I V +++++ Q +
Sbjct: 997 LSKERKLLEERISDLT---TNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQEL 1053
Query: 140 MMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELNEALSA-KEEIAQR 198
++ ++ +++ ++ ++ +L QL K EEL AL+ +EIAQ+
Sbjct: 1054 EKLKRKLEGDASDFHEQIADLQAQIA-------ELKMQLAKKEEELQAALARLDDEIAQK 1106
Query: 199 ------CHELDMQVAALQEE--------------KSSLLAENQVLMERLNQS-DSIEDPN 237
EL+ ++ LQE+ K L E + L L + DS
Sbjct: 1107 NNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQ 1166
Query: 238 SPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIR----CEELEKEISELRQQNDELT--- 290
+R ++ + L EET EA + R + EEL +++ + ++ L
Sbjct: 1167 ELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNK 1226
Query: 291 -TLADEAQSLKDEIDVLRHSSDKVS----KLEGQVESYKKKLEDLGDLRRQVKLLEEKNT 345
TL E L E+ VL + +V KLE QV+ + K D R ++ K
Sbjct: 1227 QTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ 1286
Query: 346 MYMQN-TVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVD 404
+++ T L E KA + + Q+ + Q L EE+++ + + ++L+E+ +
Sbjct: 1287 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1346
Query: 405 SLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIR 464
SLQ + D EE+ Q E ++T + S++ A+ + E
Sbjct: 1347 SLQDQLD-------------EEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEG 1393
Query: 465 EKLIRLQHENKMLKLNQEGSDNEKIAL----LQSLLDDA-----NLRK--NELETENRLV 513
+K + + EN + ++ + +K+ LQ LDD N R+ + LE + R
Sbjct: 1394 KKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKF 1453
Query: 514 NQRLLEVQS----QVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAII 569
+Q L E ++ +E ++ + K ++ L + LEE LE E + +A +
Sbjct: 1454 DQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEM 1513
Query: 570 EDLEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPE 629
EDL ++ + EL+++ R E +M++M+ + ++ ++ ++ T D K
Sbjct: 1514 EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQA---TEDAKLR--LEVN 1568
Query: 630 IQALKNQLQERDRLFHSLEKEYEKTKSQREMEE 662
+QALK Q ERD + E ++ + QR++ E
Sbjct: 1569 MQALKGQF-ERDLQARDEQNEEKRRQLQRQLHE 1600
Score = 92.8 bits (229), Expect = 1e-18
Identities = 94/449 (20%), Positives = 204/449 (45%), Gaps = 34/449 (7%)
Query: 169 DAYVDLDRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLN 228
+A +L+R K E+ + +S+K+++ + HEL+ AL+ + + + + L + L
Sbjct: 1497 EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQ 1556
Query: 229 QSDSIE---DPNSPA--GRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEIS--- 280
++ + + N A G+ LQ + EQ +E+ +L+ +Y E+ K+ +
Sbjct: 1557 ATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAA 1616
Query: 281 ----ELRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQ 336
+L +L AD A ++E + ++ KL+ Q++ ++++LED R +
Sbjct: 1617 AAKKKLEGDLKDLELQADSAIKGREE------AIKQLRKLQAQMKDFQRELEDARASRDE 1670
Query: 337 V----KLLEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKL 392
+ K E+K + + L+E+L A AR Q + K ++ E L+ + L
Sbjct: 1671 IFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAE---ELASSLSGRNAL 1727
Query: 393 DFEYKRLKEKVDSLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSD 452
E +RL+ ++ L++E L E+ +++ + +R Q QL+ + + + ++
Sbjct: 1728 QDEKRRLEARIAQLEEE---LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNE 1784
Query: 453 SLAAEIV--TPEIREKLIRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELETEN 510
S ++ E+R KL ++ K + + KIA L+ ++ K
Sbjct: 1785 SARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSL 1844
Query: 511 RLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQ-KKRAII 569
+ +++L E+ QVE+ +K + +AE K+L+ LE+ E + + +R +
Sbjct: 1845 KQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQ 1904
Query: 570 EDLEPRFNNSSL---KIEELQEALRKKEE 595
+L+ ++ ++ L+ LR+ E
Sbjct: 1905 RELDEATESNEAMGREVNALKSKLRRGNE 1933
Score = 87.8 bits (216), Expect = 3e-17
Identities = 113/490 (23%), Positives = 217/490 (44%), Gaps = 80/490 (16%)
Query: 175 DRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSDSIE 234
+ +++ +EL + +++ EL+ + + L EEK+ L + Q E +++ +
Sbjct: 851 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM- 909
Query: 235 DPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLAD 294
++L + ++L+E +EA ++ R ++L+ E ++ QQ +L +
Sbjct: 910 ---------RVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE 960
Query: 295 EAQSLKDEIDVLRHSSD-KVSKLEGQVESYKKKLEDLGD-LRRQVKLLEEKNTMYMQNTV 352
E ++ + ++ + + +++ K+ KLE ++ ++D + L ++ KLLEE+ T
Sbjct: 961 EEEAARQKLQLEKVTAEAKIKKLEDEI----LVMDDQNNKLSKERKLLEER---ISDLTT 1013
Query: 353 SLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDR 412
+L EE KA ++ + EL+ RL +E K + L+K K +
Sbjct: 1014 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE--------------LEKLKRK 1059
Query: 413 LRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQH 472
L + E I +L QAQ +L M L +E A + EI +K
Sbjct: 1060 LEGDASDFHEQIADL---QAQIAELK----MQLAKKEEELQAALARLDDEIAQK------ 1106
Query: 473 ENKMLKLNQ-EGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSL 531
N + K+ + EG I+ LQ LD +N+ E + R + + L +++++E+ S
Sbjct: 1107 NNALKKIRELEG----HISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDST 1162
Query: 532 ---QDQGSKAEDSVLLKKKLEEHLEKLHEAN-NELQKKRAIIEDLEPRFNNSSLKIEELQ 587
Q+ +K E V + KK + + HEA E+++K A +EEL
Sbjct: 1163 ATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHA-------------QAVEELT 1209
Query: 588 EALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRLFHSL 647
E L E+ K R K L+K K + K+N A E++ L QE + L
Sbjct: 1210 EQL----EQFK----RAKANLDKNKQTLE----KENADLAGELRVLGQAKQEVEHKKKKL 1257
Query: 648 EKEYEKTKSQ 657
E + ++ +S+
Sbjct: 1258 EAQVQELQSK 1267
Score = 70.9 bits (172), Expect = 4e-12
Identities = 87/372 (23%), Positives = 159/372 (42%), Gaps = 48/372 (12%)
Query: 336 QVKLLEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFE 395
QV EE+ +E +KA +LE Q+ E +N L E+ + +L E
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 905
Query: 396 YKRLKEKVDSLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLA 455
+ ++ ++ + ++E + + E ++ E E+ E + Q ++ L Q + A
Sbjct: 906 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 965
Query: 456 AEIVTPEIREKLIRLQHENKMLKLNQE----GSDNEKIALLQSLLDD--ANLRKNELETE 509
+ + +L ++ E K+ KL E N K++ + LL++ ++L N E E
Sbjct: 966 RQ------KLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE 1019
Query: 510 NRLVNQRLL--EVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRA 567
+ N L + +S + EL+ L+ + ++ LK+KLE HE +LQ A
Sbjct: 1020 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQ---A 1076
Query: 568 IIEDLEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLE------------KAKSVI 615
I +L+ + + K EELQ AL + ++E+ Q KK E ++
Sbjct: 1077 QIAELKMQL---AKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAA 1133
Query: 616 RTLDPKQNQGAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQREMEEKYIVSAWYNMGMT 675
R KQ + E++ALK + LE + T +Q+E+ K +T
Sbjct: 1134 RNKAEKQKRDLGEELEALKTE----------LEDTLDSTATQQELRAK------REQEVT 1177
Query: 676 LHKKAAEDRLAS 687
+ KKA ++ S
Sbjct: 1178 VLKKALDEETRS 1189
Score = 68.6 bits (166), Expect = 2e-11
Identities = 76/327 (23%), Positives = 154/327 (47%), Gaps = 51/327 (15%)
Query: 359 RKANAARSQLETYKRQV-------VELQN----RLSEESKKADKLDFEYKRLKEKVDSLQ 407
RKA A R Q T + + ++L+N RL + K ++ + + ++ K D LQ
Sbjct: 803 RKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQ 862
Query: 408 KEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKL 467
K K+R + + LKE ++ + QLT + + ++ L AE E
Sbjct: 863 KTKERQQKAENELKE-------LEQKHSQLTEEKNLLQEQLQAETELYAEA-----EEMR 910
Query: 468 IRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEEL 527
+RL + + L+ E + +++ L++ R +L+ E + + Q++L+++ Q+EE
Sbjct: 911 VRLAAKKQELE--------EILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 962
Query: 528 QKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQ 587
+ + Q + + KKLE+ + + + NN+L K+R ++E+ +I +L
Sbjct: 963 EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE----------RISDLT 1012
Query: 588 EALRKKEEEMKQMEERYKKYLEKAKSVIRTLDP--KQNQGAAPEIQALKNQLQERDRLFH 645
L ++EE+ K + K K +S+I L+ K+ + + E++ LK +L+ FH
Sbjct: 1013 TNLAEEEEKAKNL----TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH 1068
Query: 646 ----SLEKEYEKTKSQREMEEKYIVSA 668
L+ + + K Q +E+ + +A
Sbjct: 1069 EQIADLQAQIAELKMQLAKKEEELQAA 1095
Score = 66.2 bits (160), Expect = 1e-10
Identities = 60/269 (22%), Positives = 125/269 (46%), Gaps = 28/269 (10%)
Query: 156 ELMSKESPVSAGNDAYVDLDRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSS 215
+LM + ++A A D + ++ EEL +LS + + L+ ++A L+EE
Sbjct: 1688 DLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE--- 1744
Query: 216 LLAENQVLMERLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEEL 275
L E Q ME + SD + A + +L T+ Q+ E+A+ ++L
Sbjct: 1745 -LEEEQGNMEAM--SDRVRKATQQAEQLSNELATERSTAQKN----ESAR-------QQL 1790
Query: 276 EKEISELRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRR 335
E++ ELR + E+ K I L K+++LE QVE ++ + +
Sbjct: 1791 ERQNKELRSKLHEMEGAV--KSKFKSTIAAL---EAKIAQLEEQVE------QEAREKQA 1839
Query: 336 QVKLLEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFE 395
K L++K+ + + +E+E + A + Q E +V +L+ +L E +++ +++
Sbjct: 1840 ATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINAN 1899
Query: 396 YKRLKEKVDSLQKEKDRLRTERDSLKETI 424
++L+ ++D + + + E ++LK +
Sbjct: 1900 RRKLQRELDEATESNEAMGREVNALKSKL 1928
Score = 49.3 bits (116), Expect = 1e-05
Identities = 64/265 (24%), Positives = 112/265 (42%), Gaps = 28/265 (10%)
Query: 155 QELMSKESPVSAGNDAYVDLDRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKS 214
+EL S S +A D L+ ++ + EEL E E ++ R + Q L
Sbjct: 1715 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQL----- 1769
Query: 215 SLLAENQVLMERLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLE-AAKDDYRIRCE 273
N++ ER S N A + QL+ Q ++L+ + +E A K ++
Sbjct: 1770 ----SNELATER-----STAQKNESARQ---QLERQNKELRSKLHEMEGAVKSKFKSTIA 1817
Query: 274 ELEKEISELRQQ-NDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLED--- 329
LE +I++L +Q E +SLK + L+ +V E YK++ E
Sbjct: 1818 ALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNA 1877
Query: 330 -LGDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRL--SEES 386
+ L+RQ++ EE++ N L+ EL +A + E R+V L+++L E+
Sbjct: 1878 RVKQLKRQLEEAEEESQRINANRRKLQRELDEATESN---EAMGREVNALKSKLRRGNET 1934
Query: 387 KKADKLDFEYKRLKEKVDSLQKEKD 411
+R+ E D ++E D
Sbjct: 1935 SFVPSRRSGGRRVIENADGSEEETD 1959
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 102 bits (254), Expect = 1e-21
Identities = 131/585 (22%), Positives = 252/585 (43%), Gaps = 82/585 (14%)
Query: 159 SKESPVSAGNDAYVDLDRQLKKTTEELN---EALSAKEEIAQRCHELDMQVAALQEEKSS 215
+KE A N+ +L+++ + TEE N E L A+ E+ E+ +++AA ++E
Sbjct: 871 TKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEE 929
Query: 216 LLAENQV-LMERLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEE 274
+L E + L E ++ ++ ++ L L+ QLE+ + +L+ K + ++
Sbjct: 930 ILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKK 989
Query: 275 LEKEISELRQQNDEL---------------TTLADEAQSLKDEIDVLRHSSDKVSKLE-- 317
LE EI + QN++L T LA+E + K+ + +S+LE
Sbjct: 990 LEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR 1049
Query: 318 --------GQVESYKKKLE-DLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAAR--- 365
++E K+KLE D D Q+ L+ + EEEL+ A A
Sbjct: 1050 LKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDE 1109
Query: 366 -SQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRLRTE-RDSLKET 423
+Q +++ EL+ +S+ + D + +++ L +E + L+TE D+L T
Sbjct: 1110 IAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDST 1169
Query: 424 I--EELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQ 481
+ELR + QE + + L ++ + E E+R+K H + +L +
Sbjct: 1170 ATQQELRAKREQEVTVLKKAL-------DEETRSHEAQVQEMRQK-----HAQAVEELTE 1217
Query: 482 EGSDNEKIALLQSLLDDANLRKNE--LETEN-------RLVNQRLLEVQSQVEELQKSLQ 532
+ L Q ANL KN+ LE EN R++ Q EV+ + ++L+ +Q
Sbjct: 1218 Q--------LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQ 1269
Query: 533 DQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPR-------FNNSSLKIEE 585
+ SK D + +L +K+H+ NE++ ++ + E + + S ++++
Sbjct: 1270 ELQSKCSDGERARAELN---DKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD 1326
Query: 586 LQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQ--NQGAAPEIQALKNQLQERDRL 643
QE L+++ + + + ++ E+ S+ LD + Q I L QL + +
Sbjct: 1327 TQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKK 1386
Query: 644 FHSLEKEYEKTKSQREMEEKYIVSAWYNMGMTLHKKAAEDRLAST 688
E + ++ +K I + K AA D+L T
Sbjct: 1387 LQDFASTVEALEEGKKRFQKEIENLTQQYE---EKAAAYDKLEKT 1428
Score = 97.8 bits (242), Expect = 3e-20
Identities = 142/633 (22%), Positives = 271/633 (42%), Gaps = 83/633 (13%)
Query: 84 LDYNHEILGQQINDFTLPDVNLIGEHSDAAELGRMLQ----LILGCAVNCEQKQEYIQAI 139
L ++L ++I+D T NL E A L ++ +I V +++++ Q +
Sbjct: 1004 LSKERKLLEERISDLT---TNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQEL 1060
Query: 140 MMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELNEALSA-KEEIAQR 198
++ ++ +++ ++ ++ +L QL K EEL AL+ +EIAQ+
Sbjct: 1061 EKLKRKLEGDASDFHEQIADLQAQIA-------ELKMQLAKKEEELQAALARLDDEIAQK 1113
Query: 199 ------CHELDMQVAALQEE--------------KSSLLAENQVLMERLNQS-DSIEDPN 237
EL+ ++ LQE+ K L E + L L + DS
Sbjct: 1114 NNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQ 1173
Query: 238 SPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIR----CEELEKEISELRQQNDELT--- 290
+R ++ + L EET EA + R + EEL +++ + ++ L
Sbjct: 1174 ELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNK 1233
Query: 291 -TLADEAQSLKDEIDVLRHSSDKVS----KLEGQVESYKKKLEDLGDLRRQVKLLEEKNT 345
TL E L E+ VL + +V KLE QV+ + K D R ++ K
Sbjct: 1234 QTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ 1293
Query: 346 MYMQN-TVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVD 404
+++ T L E KA + + Q+ + Q L EE+++ + + ++L+E+ +
Sbjct: 1294 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1353
Query: 405 SLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIR 464
SLQ + D EE+ Q E ++T + S++ A+ + E
Sbjct: 1354 SLQDQLD-------------EEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEG 1400
Query: 465 EKLIRLQHENKMLKLNQEGSDNEKIAL----LQSLLDDA-----NLRK--NELETENRLV 513
+K + + EN + ++ + +K+ LQ LDD N R+ + LE + R
Sbjct: 1401 KKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKF 1460
Query: 514 NQRLLEVQS----QVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAII 569
+Q L E ++ +E ++ + K ++ L + LEE LE E + +A +
Sbjct: 1461 DQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEM 1520
Query: 570 EDLEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPE 629
EDL ++ + EL+++ R E +M++M+ + ++ ++ ++ T D K
Sbjct: 1521 EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQA---TEDAKLR--LEVN 1575
Query: 630 IQALKNQLQERDRLFHSLEKEYEKTKSQREMEE 662
+QALK Q ERD + E ++ + QR++ E
Sbjct: 1576 MQALKGQF-ERDLQARDEQNEEKRRQLQRQLHE 1607
Score = 92.8 bits (229), Expect = 1e-18
Identities = 94/449 (20%), Positives = 204/449 (45%), Gaps = 34/449 (7%)
Query: 169 DAYVDLDRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLN 228
+A +L+R K E+ + +S+K+++ + HEL+ AL+ + + + + L + L
Sbjct: 1504 EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQ 1563
Query: 229 QSDSIE---DPNSPA--GRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEIS--- 280
++ + + N A G+ LQ + EQ +E+ +L+ +Y E+ K+ +
Sbjct: 1564 ATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAA 1623
Query: 281 ----ELRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQ 336
+L +L AD A ++E + ++ KL+ Q++ ++++LED R +
Sbjct: 1624 AAKKKLEGDLKDLELQADSAIKGREE------AIKQLRKLQAQMKDFQRELEDARASRDE 1677
Query: 337 V----KLLEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKL 392
+ K E+K + + L+E+L A AR Q + K ++ E L+ + L
Sbjct: 1678 IFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAE---ELASSLSGRNAL 1734
Query: 393 DFEYKRLKEKVDSLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSD 452
E +RL+ ++ L++E L E+ +++ + +R Q QL+ + + + ++
Sbjct: 1735 QDEKRRLEARIAQLEEE---LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNE 1791
Query: 453 SLAAEIV--TPEIREKLIRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELETEN 510
S ++ E+R KL ++ K + + KIA L+ ++ K
Sbjct: 1792 SARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSL 1851
Query: 511 RLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQ-KKRAII 569
+ +++L E+ QVE+ +K + +AE K+L+ LE+ E + + +R +
Sbjct: 1852 KQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQ 1911
Query: 570 EDLEPRFNNSSL---KIEELQEALRKKEE 595
+L+ ++ ++ L+ LR+ E
Sbjct: 1912 RELDEATESNEAMGREVNALKSKLRRGNE 1940
Score = 87.8 bits (216), Expect = 3e-17
Identities = 113/490 (23%), Positives = 217/490 (44%), Gaps = 80/490 (16%)
Query: 175 DRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSDSIE 234
+ +++ +EL + +++ EL+ + + L EEK+ L + Q E +++ +
Sbjct: 858 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM- 916
Query: 235 DPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLAD 294
++L + ++L+E +EA ++ R ++L+ E ++ QQ +L +
Sbjct: 917 ---------RVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE 967
Query: 295 EAQSLKDEIDVLRHSSD-KVSKLEGQVESYKKKLEDLGD-LRRQVKLLEEKNTMYMQNTV 352
E ++ + ++ + + +++ K+ KLE ++ ++D + L ++ KLLEE+ T
Sbjct: 968 EEEAARQKLQLEKVTAEAKIKKLEDEI----LVMDDQNNKLSKERKLLEER---ISDLTT 1020
Query: 353 SLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDR 412
+L EE KA ++ + EL+ RL +E K + L+K K +
Sbjct: 1021 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE--------------LEKLKRK 1066
Query: 413 LRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQH 472
L + E I +L QAQ +L M L +E A + EI +K
Sbjct: 1067 LEGDASDFHEQIADL---QAQIAELK----MQLAKKEEELQAALARLDDEIAQK------ 1113
Query: 473 ENKMLKLNQ-EGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSL 531
N + K+ + EG I+ LQ LD +N+ E + R + + L +++++E+ S
Sbjct: 1114 NNALKKIRELEG----HISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDST 1169
Query: 532 ---QDQGSKAEDSVLLKKKLEEHLEKLHEAN-NELQKKRAIIEDLEPRFNNSSLKIEELQ 587
Q+ +K E V + KK + + HEA E+++K A +EEL
Sbjct: 1170 ATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHA-------------QAVEELT 1216
Query: 588 EALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRLFHSL 647
E L E+ K R K L+K K + K+N A E++ L QE + L
Sbjct: 1217 EQL----EQFK----RAKANLDKNKQTLE----KENADLAGELRVLGQAKQEVEHKKKKL 1264
Query: 648 EKEYEKTKSQ 657
E + ++ +S+
Sbjct: 1265 EAQVQELQSK 1274
Score = 70.9 bits (172), Expect = 4e-12
Identities = 87/372 (23%), Positives = 159/372 (42%), Gaps = 48/372 (12%)
Query: 336 QVKLLEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFE 395
QV EE+ +E +KA +LE Q+ E +N L E+ + +L E
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912
Query: 396 YKRLKEKVDSLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLA 455
+ ++ ++ + ++E + + E ++ E E+ E + Q ++ L Q + A
Sbjct: 913 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 972
Query: 456 AEIVTPEIREKLIRLQHENKMLKLNQE----GSDNEKIALLQSLLDD--ANLRKNELETE 509
+ + +L ++ E K+ KL E N K++ + LL++ ++L N E E
Sbjct: 973 RQ------KLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE 1026
Query: 510 NRLVNQRLL--EVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRA 567
+ N L + +S + EL+ L+ + ++ LK+KLE HE +LQ A
Sbjct: 1027 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQ---A 1083
Query: 568 IIEDLEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLE------------KAKSVI 615
I +L+ + + K EELQ AL + ++E+ Q KK E ++
Sbjct: 1084 QIAELKMQL---AKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAA 1140
Query: 616 RTLDPKQNQGAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQREMEEKYIVSAWYNMGMT 675
R KQ + E++ALK + LE + T +Q+E+ K +T
Sbjct: 1141 RNKAEKQKRDLGEELEALKTE----------LEDTLDSTATQQELRAK------REQEVT 1184
Query: 676 LHKKAAEDRLAS 687
+ KKA ++ S
Sbjct: 1185 VLKKALDEETRS 1196
Score = 68.6 bits (166), Expect = 2e-11
Identities = 76/327 (23%), Positives = 154/327 (47%), Gaps = 51/327 (15%)
Query: 359 RKANAARSQLETYKRQV-------VELQN----RLSEESKKADKLDFEYKRLKEKVDSLQ 407
RKA A R Q T + + ++L+N RL + K ++ + + ++ K D LQ
Sbjct: 810 RKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQ 869
Query: 408 KEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKL 467
K K+R + + LKE ++ + QLT + + ++ L AE E
Sbjct: 870 KTKERQQKAENELKE-------LEQKHSQLTEEKNLLQEQLQAETELYAEA-----EEMR 917
Query: 468 IRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEEL 527
+RL + + L+ E + +++ L++ R +L+ E + + Q++L+++ Q+EE
Sbjct: 918 VRLAAKKQELE--------EILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 969
Query: 528 QKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQ 587
+ + Q + + KKLE+ + + + NN+L K+R ++E+ +I +L
Sbjct: 970 EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE----------RISDLT 1019
Query: 588 EALRKKEEEMKQMEERYKKYLEKAKSVIRTLDP--KQNQGAAPEIQALKNQLQERDRLFH 645
L ++EE+ K + K K +S+I L+ K+ + + E++ LK +L+ FH
Sbjct: 1020 TNLAEEEEKAKNL----TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH 1075
Query: 646 ----SLEKEYEKTKSQREMEEKYIVSA 668
L+ + + K Q +E+ + +A
Sbjct: 1076 EQIADLQAQIAELKMQLAKKEEELQAA 1102
Score = 66.2 bits (160), Expect = 1e-10
Identities = 60/269 (22%), Positives = 125/269 (46%), Gaps = 28/269 (10%)
Query: 156 ELMSKESPVSAGNDAYVDLDRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSS 215
+LM + ++A A D + ++ EEL +LS + + L+ ++A L+EE
Sbjct: 1695 DLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE--- 1751
Query: 216 LLAENQVLMERLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEEL 275
L E Q ME + SD + A + +L T+ Q+ E+A+ ++L
Sbjct: 1752 -LEEEQGNMEAM--SDRVRKATQQAEQLSNELATERSTAQKN----ESAR-------QQL 1797
Query: 276 EKEISELRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRR 335
E++ ELR + E+ K I L K+++LE QVE ++ + +
Sbjct: 1798 ERQNKELRSKLHEMEGAV--KSKFKSTIAAL---EAKIAQLEEQVE------QEAREKQA 1846
Query: 336 QVKLLEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFE 395
K L++K+ + + +E+E + A + Q E +V +L+ +L E +++ +++
Sbjct: 1847 ATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINAN 1906
Query: 396 YKRLKEKVDSLQKEKDRLRTERDSLKETI 424
++L+ ++D + + + E ++LK +
Sbjct: 1907 RRKLQRELDEATESNEAMGREVNALKSKL 1935
Score = 49.3 bits (116), Expect = 1e-05
Identities = 64/265 (24%), Positives = 112/265 (42%), Gaps = 28/265 (10%)
Query: 155 QELMSKESPVSAGNDAYVDLDRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKS 214
+EL S S +A D L+ ++ + EEL E E ++ R + Q L
Sbjct: 1722 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQL----- 1776
Query: 215 SLLAENQVLMERLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLE-AAKDDYRIRCE 273
N++ ER S N A + QL+ Q ++L+ + +E A K ++
Sbjct: 1777 ----SNELATER-----STAQKNESARQ---QLERQNKELRSKLHEMEGAVKSKFKSTIA 1824
Query: 274 ELEKEISELRQQ-NDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLED--- 329
LE +I++L +Q E +SLK + L+ +V E YK++ E
Sbjct: 1825 ALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNA 1884
Query: 330 -LGDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRL--SEES 386
+ L+RQ++ EE++ N L+ EL +A + E R+V L+++L E+
Sbjct: 1885 RVKQLKRQLEEAEEESQRINANRRKLQRELDEATESN---EAMGREVNALKSKLRRGNET 1941
Query: 387 KKADKLDFEYKRLKEKVDSLQKEKD 411
+R+ E D ++E D
Sbjct: 1942 SFVPSRRSGGRRVIENADGSEEETD 1966
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 102 bits (254), Expect = 1e-21
Identities = 131/585 (22%), Positives = 252/585 (43%), Gaps = 82/585 (14%)
Query: 159 SKESPVSAGNDAYVDLDRQLKKTTEELN---EALSAKEEIAQRCHELDMQVAALQEEKSS 215
+KE A N+ +L+++ + TEE N E L A+ E+ E+ +++AA ++E
Sbjct: 871 TKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEE 929
Query: 216 LLAENQV-LMERLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEE 274
+L E + L E ++ ++ ++ L L+ QLE+ + +L+ K + ++
Sbjct: 930 ILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKK 989
Query: 275 LEKEISELRQQNDEL---------------TTLADEAQSLKDEIDVLRHSSDKVSKLE-- 317
LE EI + QN++L T LA+E + K+ + +S+LE
Sbjct: 990 LEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR 1049
Query: 318 --------GQVESYKKKLE-DLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAAR--- 365
++E K+KLE D D Q+ L+ + EEEL+ A A
Sbjct: 1050 LKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDE 1109
Query: 366 -SQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRLRTE-RDSLKET 423
+Q +++ EL+ +S+ + D + +++ L +E + L+TE D+L T
Sbjct: 1110 IAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDST 1169
Query: 424 I--EELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQ 481
+ELR + QE + + L ++ + E E+R+K H + +L +
Sbjct: 1170 ATQQELRAKREQEVTVLKKAL-------DEETRSHEAQVQEMRQK-----HAQAVEELTE 1217
Query: 482 EGSDNEKIALLQSLLDDANLRKNE--LETEN-------RLVNQRLLEVQSQVEELQKSLQ 532
+ L Q ANL KN+ LE EN R++ Q EV+ + ++L+ +Q
Sbjct: 1218 Q--------LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQ 1269
Query: 533 DQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPR-------FNNSSLKIEE 585
+ SK D + +L +K+H+ NE++ ++ + E + + S ++++
Sbjct: 1270 ELQSKCSDGERARAELN---DKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD 1326
Query: 586 LQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQ--NQGAAPEIQALKNQLQERDRL 643
QE L+++ + + + ++ E+ S+ LD + Q I L QL + +
Sbjct: 1327 TQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKK 1386
Query: 644 FHSLEKEYEKTKSQREMEEKYIVSAWYNMGMTLHKKAAEDRLAST 688
E + ++ +K I + K AA D+L T
Sbjct: 1387 LQDFASTVEALEEGKKRFQKEIENLTQQYE---EKAAAYDKLEKT 1428
Score = 97.8 bits (242), Expect = 3e-20
Identities = 142/633 (22%), Positives = 271/633 (42%), Gaps = 83/633 (13%)
Query: 84 LDYNHEILGQQINDFTLPDVNLIGEHSDAAELGRMLQ----LILGCAVNCEQKQEYIQAI 139
L ++L ++I+D T NL E A L ++ +I V +++++ Q +
Sbjct: 1004 LSKERKLLEERISDLT---TNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQEL 1060
Query: 140 MMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELNEALSA-KEEIAQR 198
++ ++ +++ ++ ++ +L QL K EEL AL+ +EIAQ+
Sbjct: 1061 EKLKRKLEGDASDFHEQIADLQAQIA-------ELKMQLAKKEEELQAALARLDDEIAQK 1113
Query: 199 ------CHELDMQVAALQEE--------------KSSLLAENQVLMERLNQS-DSIEDPN 237
EL+ ++ LQE+ K L E + L L + DS
Sbjct: 1114 NNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQ 1173
Query: 238 SPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIR----CEELEKEISELRQQNDELT--- 290
+R ++ + L EET EA + R + EEL +++ + ++ L
Sbjct: 1174 ELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNK 1233
Query: 291 -TLADEAQSLKDEIDVLRHSSDKVS----KLEGQVESYKKKLEDLGDLRRQVKLLEEKNT 345
TL E L E+ VL + +V KLE QV+ + K D R ++ K
Sbjct: 1234 QTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ 1293
Query: 346 MYMQN-TVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVD 404
+++ T L E KA + + Q+ + Q L EE+++ + + ++L+E+ +
Sbjct: 1294 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1353
Query: 405 SLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIR 464
SLQ + D EE+ Q E ++T + S++ A+ + E
Sbjct: 1354 SLQDQLD-------------EEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEG 1400
Query: 465 EKLIRLQHENKMLKLNQEGSDNEKIAL----LQSLLDDA-----NLRK--NELETENRLV 513
+K + + EN + ++ + +K+ LQ LDD N R+ + LE + R
Sbjct: 1401 KKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKF 1460
Query: 514 NQRLLEVQS----QVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAII 569
+Q L E ++ +E ++ + K ++ L + LEE LE E + +A +
Sbjct: 1461 DQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEM 1520
Query: 570 EDLEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPE 629
EDL ++ + EL+++ R E +M++M+ + ++ ++ ++ T D K
Sbjct: 1521 EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQA---TEDAKLR--LEVN 1575
Query: 630 IQALKNQLQERDRLFHSLEKEYEKTKSQREMEE 662
+QALK Q ERD + E ++ + QR++ E
Sbjct: 1576 MQALKGQF-ERDLQARDEQNEEKRRQLQRQLHE 1607
Score = 94.0 bits (232), Expect = 4e-19
Identities = 142/600 (23%), Positives = 249/600 (41%), Gaps = 69/600 (11%)
Query: 154 IQELMSK----ESPVSAGNDAYVDLDRQLKKTTEELNEA----LSAKEEIAQRCHELDMQ 205
+QEL SK E + ND L +++ T LNEA + +++A +L
Sbjct: 1268 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDT 1327
Query: 206 VAALQEEKSSLLAENQVLMERLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAK 265
LQEE L + L + + +S++D L+ + L + +
Sbjct: 1328 QELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL 1387
Query: 266 DDYRIRCEELE-------KEISELRQQNDELTTLADEAQSLKD----EIDVLRHSSDKVS 314
D+ E LE KEI L QQ +E D+ + K+ E+D L D
Sbjct: 1388 QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQR 1447
Query: 315 KLEGQVESYKKKLEDLGDLRRQVKLLEEKN--TMYMQNTVSLEEELRKANAARSQLETYK 372
+L +E ++K + L L EEKN + Y E E R+ L
Sbjct: 1448 QLVSNLEKKQRKFDQL--------LAEEKNISSKYADERDRAEAEAREKETKALSLARAL 1499
Query: 373 RQVVELQNRLSEESK--KADKLDFEYKR--LKEKVDSLQKEKDRLRTERDSLKETIEELR 428
+ +E + L +K KA+ D + + + V L+K K L T+ + +K +EEL
Sbjct: 1500 EEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELE 1559
Query: 429 C-VQAQE-GQLTTQ-GLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSD 485
+QA E +L + + L Q D A + E R +L R HE + +L E
Sbjct: 1560 DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYET-ELEDERKQ 1618
Query: 486 NEKIALLQSLLDDANLRKNELETENRLVNQ-----RLLEVQSQVEELQKSLQDQGSK--- 537
A + L+ +L+ EL+ ++ + + +L ++Q+Q+++ Q+ L+D +
Sbjct: 1619 RALAAAAKKKLE-GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDE 1677
Query: 538 ----AEDSVLLKKKLEEHLEKLHE--ANNELQKKRAII--EDLEPRFNNSSLKIEELQEA 589
A+++ K LE L +L E A E +K+A + E+L +S LQ+
Sbjct: 1678 IFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDE 1737
Query: 590 LRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRLFHSLEK 649
R+ E + Q+EE LE+ + + + + + A + + L N+L S +
Sbjct: 1738 KRRLEARIAQLEEE----LEEEQGNMEAMSDRVRK-ATQQAEQLSNELATE----RSTAQ 1788
Query: 650 EYEKTKSQREMEEKYIVSAWYNMGMTLHKK------AAEDRLASTGSGQSFLARQRQATS 703
+ E + Q E + K + S + M + K A E ++A AR++QA +
Sbjct: 1789 KNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAT 1848
Score = 92.4 bits (228), Expect = 1e-18
Identities = 89/416 (21%), Positives = 189/416 (45%), Gaps = 30/416 (7%)
Query: 169 DAYVDLDRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLN 228
+A +L+R K E+ + +S+K+++ + HEL+ AL+ + + + + L + L
Sbjct: 1504 EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQ 1563
Query: 229 QSDSIE---DPNSPA--GRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEIS--- 280
++ + + N A G+ LQ + EQ +E+ +L+ +Y E+ K+ +
Sbjct: 1564 ATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAA 1623
Query: 281 ----ELRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQ 336
+L +L AD A ++E + ++ KL+ Q++ ++++LED R +
Sbjct: 1624 AAKKKLEGDLKDLELQADSAIKGREE------AIKQLRKLQAQMKDFQRELEDARASRDE 1677
Query: 337 V----KLLEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKL 392
+ K E+K + + L+E+L A AR Q + K ++ E L+ + L
Sbjct: 1678 IFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAE---ELASSLSGRNAL 1734
Query: 393 DFEYKRLKEKVDSLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSD 452
E +RL+ ++ L++E L E+ +++ + +R Q QL+ + + + ++
Sbjct: 1735 QDEKRRLEARIAQLEEE---LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNE 1791
Query: 453 SLAAEIV--TPEIREKLIRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELETEN 510
S ++ E+R KL ++ K + + KIA L+ ++ K
Sbjct: 1792 SARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSL 1851
Query: 511 RLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKR 566
+ +++L E+ QVE+ +K + +AE K+L+ LE+ E + + R
Sbjct: 1852 KQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANR 1907
Score = 87.8 bits (216), Expect = 3e-17
Identities = 113/490 (23%), Positives = 217/490 (44%), Gaps = 80/490 (16%)
Query: 175 DRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSDSIE 234
+ +++ +EL + +++ EL+ + + L EEK+ L + Q E +++ +
Sbjct: 858 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM- 916
Query: 235 DPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLAD 294
++L + ++L+E +EA ++ R ++L+ E ++ QQ +L +
Sbjct: 917 ---------RVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE 967
Query: 295 EAQSLKDEIDVLRHSSD-KVSKLEGQVESYKKKLEDLGD-LRRQVKLLEEKNTMYMQNTV 352
E ++ + ++ + + +++ K+ KLE ++ ++D + L ++ KLLEE+ T
Sbjct: 968 EEEAARQKLQLEKVTAEAKIKKLEDEI----LVMDDQNNKLSKERKLLEER---ISDLTT 1020
Query: 353 SLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDR 412
+L EE KA ++ + EL+ RL +E K + L+K K +
Sbjct: 1021 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE--------------LEKLKRK 1066
Query: 413 LRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQH 472
L + E I +L QAQ +L M L +E A + EI +K
Sbjct: 1067 LEGDASDFHEQIADL---QAQIAELK----MQLAKKEEELQAALARLDDEIAQK------ 1113
Query: 473 ENKMLKLNQ-EGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSL 531
N + K+ + EG I+ LQ LD +N+ E + R + + L +++++E+ S
Sbjct: 1114 NNALKKIRELEG----HISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDST 1169
Query: 532 ---QDQGSKAEDSVLLKKKLEEHLEKLHEAN-NELQKKRAIIEDLEPRFNNSSLKIEELQ 587
Q+ +K E V + KK + + HEA E+++K A +EEL
Sbjct: 1170 ATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHA-------------QAVEELT 1216
Query: 588 EALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRLFHSL 647
E L E+ K R K L+K K + K+N A E++ L QE + L
Sbjct: 1217 EQL----EQFK----RAKANLDKNKQTLE----KENADLAGELRVLGQAKQEVEHKKKKL 1264
Query: 648 EKEYEKTKSQ 657
E + ++ +S+
Sbjct: 1265 EAQVQELQSK 1274
Score = 70.9 bits (172), Expect = 4e-12
Identities = 87/372 (23%), Positives = 159/372 (42%), Gaps = 48/372 (12%)
Query: 336 QVKLLEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFE 395
QV EE+ +E +KA +LE Q+ E +N L E+ + +L E
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912
Query: 396 YKRLKEKVDSLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLA 455
+ ++ ++ + ++E + + E ++ E E+ E + Q ++ L Q + A
Sbjct: 913 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 972
Query: 456 AEIVTPEIREKLIRLQHENKMLKLNQE----GSDNEKIALLQSLLDD--ANLRKNELETE 509
+ + +L ++ E K+ KL E N K++ + LL++ ++L N E E
Sbjct: 973 RQ------KLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE 1026
Query: 510 NRLVNQRLL--EVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRA 567
+ N L + +S + EL+ L+ + ++ LK+KLE HE +LQ A
Sbjct: 1027 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQ---A 1083
Query: 568 IIEDLEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLE------------KAKSVI 615
I +L+ + + K EELQ AL + ++E+ Q KK E ++
Sbjct: 1084 QIAELKMQL---AKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAA 1140
Query: 616 RTLDPKQNQGAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQREMEEKYIVSAWYNMGMT 675
R KQ + E++ALK + LE + T +Q+E+ K +T
Sbjct: 1141 RNKAEKQKRDLGEELEALKTE----------LEDTLDSTATQQELRAK------REQEVT 1184
Query: 676 LHKKAAEDRLAS 687
+ KKA ++ S
Sbjct: 1185 VLKKALDEETRS 1196
Score = 68.6 bits (166), Expect = 2e-11
Identities = 76/327 (23%), Positives = 154/327 (47%), Gaps = 51/327 (15%)
Query: 359 RKANAARSQLETYKRQV-------VELQN----RLSEESKKADKLDFEYKRLKEKVDSLQ 407
RKA A R Q T + + ++L+N RL + K ++ + + ++ K D LQ
Sbjct: 810 RKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQ 869
Query: 408 KEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKL 467
K K+R + + LKE ++ + QLT + + ++ L AE E
Sbjct: 870 KTKERQQKAENELKE-------LEQKHSQLTEEKNLLQEQLQAETELYAEA-----EEMR 917
Query: 468 IRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEEL 527
+RL + + L+ E + +++ L++ R +L+ E + + Q++L+++ Q+EE
Sbjct: 918 VRLAAKKQELE--------EILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 969
Query: 528 QKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQ 587
+ + Q + + KKLE+ + + + NN+L K+R ++E+ +I +L
Sbjct: 970 EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE----------RISDLT 1019
Query: 588 EALRKKEEEMKQMEERYKKYLEKAKSVIRTLDP--KQNQGAAPEIQALKNQLQERDRLFH 645
L ++EE+ K + K K +S+I L+ K+ + + E++ LK +L+ FH
Sbjct: 1020 TNLAEEEEKAKNL----TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH 1075
Query: 646 ----SLEKEYEKTKSQREMEEKYIVSA 668
L+ + + K Q +E+ + +A
Sbjct: 1076 EQIADLQAQIAELKMQLAKKEEELQAA 1102
Score = 66.2 bits (160), Expect = 1e-10
Identities = 60/269 (22%), Positives = 125/269 (46%), Gaps = 28/269 (10%)
Query: 156 ELMSKESPVSAGNDAYVDLDRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSS 215
+LM + ++A A D + ++ EEL +LS + + L+ ++A L+EE
Sbjct: 1695 DLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE--- 1751
Query: 216 LLAENQVLMERLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEEL 275
L E Q ME + SD + A + +L T+ Q+ E+A+ ++L
Sbjct: 1752 -LEEEQGNMEAM--SDRVRKATQQAEQLSNELATERSTAQKN----ESAR-------QQL 1797
Query: 276 EKEISELRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRR 335
E++ ELR + E+ K I L K+++LE QVE ++ + +
Sbjct: 1798 ERQNKELRSKLHEMEGAV--KSKFKSTIAAL---EAKIAQLEEQVE------QEAREKQA 1846
Query: 336 QVKLLEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFE 395
K L++K+ + + +E+E + A + Q E +V +L+ +L E +++ +++
Sbjct: 1847 ATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINAN 1906
Query: 396 YKRLKEKVDSLQKEKDRLRTERDSLKETI 424
++L+ ++D + + + E ++LK +
Sbjct: 1907 RRKLQRELDEATESNEAMGREVNALKSKL 1935
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 102 bits (254), Expect = 1e-21
Identities = 131/585 (22%), Positives = 252/585 (43%), Gaps = 82/585 (14%)
Query: 159 SKESPVSAGNDAYVDLDRQLKKTTEELN---EALSAKEEIAQRCHELDMQVAALQEEKSS 215
+KE A N+ +L+++ + TEE N E L A+ E+ E+ +++AA ++E
Sbjct: 864 TKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEE 922
Query: 216 LLAENQV-LMERLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEE 274
+L E + L E ++ ++ ++ L L+ QLE+ + +L+ K + ++
Sbjct: 923 ILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKK 982
Query: 275 LEKEISELRQQNDEL---------------TTLADEAQSLKDEIDVLRHSSDKVSKLE-- 317
LE EI + QN++L T LA+E + K+ + +S+LE
Sbjct: 983 LEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR 1042
Query: 318 --------GQVESYKKKLE-DLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAAR--- 365
++E K+KLE D D Q+ L+ + EEEL+ A A
Sbjct: 1043 LKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDE 1102
Query: 366 -SQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRLRTE-RDSLKET 423
+Q +++ EL+ +S+ + D + +++ L +E + L+TE D+L T
Sbjct: 1103 IAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDST 1162
Query: 424 I--EELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQ 481
+ELR + QE + + L ++ + E E+R+K H + +L +
Sbjct: 1163 ATQQELRAKREQEVTVLKKAL-------DEETRSHEAQVQEMRQK-----HAQAVEELTE 1210
Query: 482 EGSDNEKIALLQSLLDDANLRKNE--LETEN-------RLVNQRLLEVQSQVEELQKSLQ 532
+ L Q ANL KN+ LE EN R++ Q EV+ + ++L+ +Q
Sbjct: 1211 Q--------LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQ 1262
Query: 533 DQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPR-------FNNSSLKIEE 585
+ SK D + +L +K+H+ NE++ ++ + E + + S ++++
Sbjct: 1263 ELQSKCSDGERARAELN---DKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD 1319
Query: 586 LQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQ--NQGAAPEIQALKNQLQERDRL 643
QE L+++ + + + ++ E+ S+ LD + Q I L QL + +
Sbjct: 1320 TQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKK 1379
Query: 644 FHSLEKEYEKTKSQREMEEKYIVSAWYNMGMTLHKKAAEDRLAST 688
E + ++ +K I + K AA D+L T
Sbjct: 1380 LQDFASTVEALEEGKKRFQKEIENLTQQYE---EKAAAYDKLEKT 1421
Score = 97.8 bits (242), Expect = 3e-20
Identities = 142/633 (22%), Positives = 271/633 (42%), Gaps = 83/633 (13%)
Query: 84 LDYNHEILGQQINDFTLPDVNLIGEHSDAAELGRMLQ----LILGCAVNCEQKQEYIQAI 139
L ++L ++I+D T NL E A L ++ +I V +++++ Q +
Sbjct: 997 LSKERKLLEERISDLT---TNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQEL 1053
Query: 140 MMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELNEALSA-KEEIAQR 198
++ ++ +++ ++ ++ +L QL K EEL AL+ +EIAQ+
Sbjct: 1054 EKLKRKLEGDASDFHEQIADLQAQIA-------ELKMQLAKKEEELQAALARLDDEIAQK 1106
Query: 199 ------CHELDMQVAALQEE--------------KSSLLAENQVLMERLNQS-DSIEDPN 237
EL+ ++ LQE+ K L E + L L + DS
Sbjct: 1107 NNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQ 1166
Query: 238 SPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIR----CEELEKEISELRQQNDELT--- 290
+R ++ + L EET EA + R + EEL +++ + ++ L
Sbjct: 1167 ELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNK 1226
Query: 291 -TLADEAQSLKDEIDVLRHSSDKVS----KLEGQVESYKKKLEDLGDLRRQVKLLEEKNT 345
TL E L E+ VL + +V KLE QV+ + K D R ++ K
Sbjct: 1227 QTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ 1286
Query: 346 MYMQN-TVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVD 404
+++ T L E KA + + Q+ + Q L EE+++ + + ++L+E+ +
Sbjct: 1287 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1346
Query: 405 SLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIR 464
SLQ + D EE+ Q E ++T + S++ A+ + E
Sbjct: 1347 SLQDQLD-------------EEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEG 1393
Query: 465 EKLIRLQHENKMLKLNQEGSDNEKIAL----LQSLLDDA-----NLRK--NELETENRLV 513
+K + + EN + ++ + +K+ LQ LDD N R+ + LE + R
Sbjct: 1394 KKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKF 1453
Query: 514 NQRLLEVQS----QVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAII 569
+Q L E ++ +E ++ + K ++ L + LEE LE E + +A +
Sbjct: 1454 DQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEM 1513
Query: 570 EDLEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPE 629
EDL ++ + EL+++ R E +M++M+ + ++ ++ ++ T D K
Sbjct: 1514 EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQA---TEDAKLR--LEVN 1568
Query: 630 IQALKNQLQERDRLFHSLEKEYEKTKSQREMEE 662
+QALK Q ERD + E ++ + QR++ E
Sbjct: 1569 MQALKGQF-ERDLQARDEQNEEKRRQLQRQLHE 1600
Score = 94.0 bits (232), Expect = 4e-19
Identities = 142/600 (23%), Positives = 249/600 (41%), Gaps = 69/600 (11%)
Query: 154 IQELMSK----ESPVSAGNDAYVDLDRQLKKTTEELNEA----LSAKEEIAQRCHELDMQ 205
+QEL SK E + ND L +++ T LNEA + +++A +L
Sbjct: 1261 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDT 1320
Query: 206 VAALQEEKSSLLAENQVLMERLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAK 265
LQEE L + L + + +S++D L+ + L + +
Sbjct: 1321 QELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL 1380
Query: 266 DDYRIRCEELE-------KEISELRQQNDELTTLADEAQSLKD----EIDVLRHSSDKVS 314
D+ E LE KEI L QQ +E D+ + K+ E+D L D
Sbjct: 1381 QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQR 1440
Query: 315 KLEGQVESYKKKLEDLGDLRRQVKLLEEKN--TMYMQNTVSLEEELRKANAARSQLETYK 372
+L +E ++K + L L EEKN + Y E E R+ L
Sbjct: 1441 QLVSNLEKKQRKFDQL--------LAEEKNISSKYADERDRAEAEAREKETKALSLARAL 1492
Query: 373 RQVVELQNRLSEESK--KADKLDFEYKR--LKEKVDSLQKEKDRLRTERDSLKETIEELR 428
+ +E + L +K KA+ D + + + V L+K K L T+ + +K +EEL
Sbjct: 1493 EEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELE 1552
Query: 429 C-VQAQE-GQLTTQ-GLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSD 485
+QA E +L + + L Q D A + E R +L R HE + +L E
Sbjct: 1553 DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYET-ELEDERKQ 1611
Query: 486 NEKIALLQSLLDDANLRKNELETENRLVNQ-----RLLEVQSQVEELQKSLQDQGSK--- 537
A + L+ +L+ EL+ ++ + + +L ++Q+Q+++ Q+ L+D +
Sbjct: 1612 RALAAAAKKKLE-GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDE 1670
Query: 538 ----AEDSVLLKKKLEEHLEKLHE--ANNELQKKRAII--EDLEPRFNNSSLKIEELQEA 589
A+++ K LE L +L E A E +K+A + E+L +S LQ+
Sbjct: 1671 IFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDE 1730
Query: 590 LRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRLFHSLEK 649
R+ E + Q+EE LE+ + + + + + A + + L N+L S +
Sbjct: 1731 KRRLEARIAQLEEE----LEEEQGNMEAMSDRVRK-ATQQAEQLSNELATE----RSTAQ 1781
Query: 650 EYEKTKSQREMEEKYIVSAWYNMGMTLHKK------AAEDRLASTGSGQSFLARQRQATS 703
+ E + Q E + K + S + M + K A E ++A AR++QA +
Sbjct: 1782 KNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAT 1841
Score = 92.4 bits (228), Expect = 1e-18
Identities = 89/416 (21%), Positives = 189/416 (45%), Gaps = 30/416 (7%)
Query: 169 DAYVDLDRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLN 228
+A +L+R K E+ + +S+K+++ + HEL+ AL+ + + + + L + L
Sbjct: 1497 EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQ 1556
Query: 229 QSDSIE---DPNSPA--GRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEIS--- 280
++ + + N A G+ LQ + EQ +E+ +L+ +Y E+ K+ +
Sbjct: 1557 ATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAA 1616
Query: 281 ----ELRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQ 336
+L +L AD A ++E + ++ KL+ Q++ ++++LED R +
Sbjct: 1617 AAKKKLEGDLKDLELQADSAIKGREE------AIKQLRKLQAQMKDFQRELEDARASRDE 1670
Query: 337 V----KLLEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKL 392
+ K E+K + + L+E+L A AR Q + K ++ E L+ + L
Sbjct: 1671 IFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAE---ELASSLSGRNAL 1727
Query: 393 DFEYKRLKEKVDSLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSD 452
E +RL+ ++ L++E L E+ +++ + +R Q QL+ + + + ++
Sbjct: 1728 QDEKRRLEARIAQLEEE---LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNE 1784
Query: 453 SLAAEIV--TPEIREKLIRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELETEN 510
S ++ E+R KL ++ K + + KIA L+ ++ K
Sbjct: 1785 SARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSL 1844
Query: 511 RLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKR 566
+ +++L E+ QVE+ +K + +AE K+L+ LE+ E + + R
Sbjct: 1845 KQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANR 1900
Score = 87.8 bits (216), Expect = 3e-17
Identities = 113/490 (23%), Positives = 217/490 (44%), Gaps = 80/490 (16%)
Query: 175 DRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSDSIE 234
+ +++ +EL + +++ EL+ + + L EEK+ L + Q E +++ +
Sbjct: 851 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEM- 909
Query: 235 DPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLAD 294
++L + ++L+E +EA ++ R ++L+ E ++ QQ +L +
Sbjct: 910 ---------RVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE 960
Query: 295 EAQSLKDEIDVLRHSSD-KVSKLEGQVESYKKKLEDLGD-LRRQVKLLEEKNTMYMQNTV 352
E ++ + ++ + + +++ K+ KLE ++ ++D + L ++ KLLEE+ T
Sbjct: 961 EEEAARQKLQLEKVTAEAKIKKLEDEI----LVMDDQNNKLSKERKLLEER---ISDLTT 1013
Query: 353 SLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDR 412
+L EE KA ++ + EL+ RL +E K + L+K K +
Sbjct: 1014 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE--------------LEKLKRK 1059
Query: 413 LRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQH 472
L + E I +L QAQ +L M L +E A + EI +K
Sbjct: 1060 LEGDASDFHEQIADL---QAQIAELK----MQLAKKEEELQAALARLDDEIAQK------ 1106
Query: 473 ENKMLKLNQ-EGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSL 531
N + K+ + EG I+ LQ LD +N+ E + R + + L +++++E+ S
Sbjct: 1107 NNALKKIRELEG----HISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDST 1162
Query: 532 ---QDQGSKAEDSVLLKKKLEEHLEKLHEAN-NELQKKRAIIEDLEPRFNNSSLKIEELQ 587
Q+ +K E V + KK + + HEA E+++K A +EEL
Sbjct: 1163 ATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHA-------------QAVEELT 1209
Query: 588 EALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRLFHSL 647
E L E+ K R K L+K K + K+N A E++ L QE + L
Sbjct: 1210 EQL----EQFK----RAKANLDKNKQTLE----KENADLAGELRVLGQAKQEVEHKKKKL 1257
Query: 648 EKEYEKTKSQ 657
E + ++ +S+
Sbjct: 1258 EAQVQELQSK 1267
Score = 70.9 bits (172), Expect = 4e-12
Identities = 87/372 (23%), Positives = 159/372 (42%), Gaps = 48/372 (12%)
Query: 336 QVKLLEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFE 395
QV EE+ +E +KA +LE Q+ E +N L E+ + +L E
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 905
Query: 396 YKRLKEKVDSLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLA 455
+ ++ ++ + ++E + + E ++ E E+ E + Q ++ L Q + A
Sbjct: 906 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 965
Query: 456 AEIVTPEIREKLIRLQHENKMLKLNQE----GSDNEKIALLQSLLDD--ANLRKNELETE 509
+ + +L ++ E K+ KL E N K++ + LL++ ++L N E E
Sbjct: 966 RQ------KLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE 1019
Query: 510 NRLVNQRLL--EVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRA 567
+ N L + +S + EL+ L+ + ++ LK+KLE HE +LQ A
Sbjct: 1020 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQ---A 1076
Query: 568 IIEDLEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLE------------KAKSVI 615
I +L+ + + K EELQ AL + ++E+ Q KK E ++
Sbjct: 1077 QIAELKMQL---AKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAA 1133
Query: 616 RTLDPKQNQGAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQREMEEKYIVSAWYNMGMT 675
R KQ + E++ALK + LE + T +Q+E+ K +T
Sbjct: 1134 RNKAEKQKRDLGEELEALKTE----------LEDTLDSTATQQELRAK------REQEVT 1177
Query: 676 LHKKAAEDRLAS 687
+ KKA ++ S
Sbjct: 1178 VLKKALDEETRS 1189
Score = 68.6 bits (166), Expect = 2e-11
Identities = 76/327 (23%), Positives = 154/327 (47%), Gaps = 51/327 (15%)
Query: 359 RKANAARSQLETYKRQV-------VELQN----RLSEESKKADKLDFEYKRLKEKVDSLQ 407
RKA A R Q T + + ++L+N RL + K ++ + + ++ K D LQ
Sbjct: 803 RKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQ 862
Query: 408 KEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKL 467
K K+R + + LKE ++ + QLT + + ++ L AE E
Sbjct: 863 KTKERQQKAENELKE-------LEQKHSQLTEEKNLLQEQLQAETELYAEA-----EEMR 910
Query: 468 IRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEEL 527
+RL + + L+ E + +++ L++ R +L+ E + + Q++L+++ Q+EE
Sbjct: 911 VRLAAKKQELE--------EILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 962
Query: 528 QKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQ 587
+ + Q + + KKLE+ + + + NN+L K+R ++E+ +I +L
Sbjct: 963 EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE----------RISDLT 1012
Query: 588 EALRKKEEEMKQMEERYKKYLEKAKSVIRTLDP--KQNQGAAPEIQALKNQLQERDRLFH 645
L ++EE+ K + K K +S+I L+ K+ + + E++ LK +L+ FH
Sbjct: 1013 TNLAEEEEKAKNL----TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH 1068
Query: 646 ----SLEKEYEKTKSQREMEEKYIVSA 668
L+ + + K Q +E+ + +A
Sbjct: 1069 EQIADLQAQIAELKMQLAKKEEELQAA 1095
Score = 66.2 bits (160), Expect = 1e-10
Identities = 60/269 (22%), Positives = 125/269 (46%), Gaps = 28/269 (10%)
Query: 156 ELMSKESPVSAGNDAYVDLDRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSS 215
+LM + ++A A D + ++ EEL +LS + + L+ ++A L+EE
Sbjct: 1688 DLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE--- 1744
Query: 216 LLAENQVLMERLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEEL 275
L E Q ME + SD + A + +L T+ Q+ E+A+ ++L
Sbjct: 1745 -LEEEQGNMEAM--SDRVRKATQQAEQLSNELATERSTAQKN----ESAR-------QQL 1790
Query: 276 EKEISELRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRR 335
E++ ELR + E+ K I L K+++LE QVE ++ + +
Sbjct: 1791 ERQNKELRSKLHEMEGAV--KSKFKSTIAAL---EAKIAQLEEQVE------QEAREKQA 1839
Query: 336 QVKLLEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFE 395
K L++K+ + + +E+E + A + Q E +V +L+ +L E +++ +++
Sbjct: 1840 ATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINAN 1899
Query: 396 YKRLKEKVDSLQKEKDRLRTERDSLKETI 424
++L+ ++D + + + E ++LK +
Sbjct: 1900 RRKLQRELDEATESNEAMGREVNALKSKL 1928
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 101 bits (251), Expect = 3e-21
Identities = 136/640 (21%), Positives = 272/640 (42%), Gaps = 109/640 (17%)
Query: 111 DAAELGRMLQLILGCAVNCEQKQEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDA 170
+ AEL R LQL + N ++++E ++A + E QH + + S G
Sbjct: 622 EVAELQRQLQLEVKNQQNIKEERERMRA-NLEELRSQHNEKVEENSTLQQRLEESEG--- 677
Query: 171 YVDLDRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSS--------------- 215
+L+K EEL + +E+ +L Q++ + +E S
Sbjct: 678 ------ELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEE 731
Query: 216 LLAENQVLMERLNQSDSIEDPNSPAGRRHLQLQTQL-EQLQEETFRLEAAKDDYRIRCEE 274
LL Q L + L + ED R L+ L E++ ++ K+ Y +
Sbjct: 732 LLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQA 791
Query: 275 LEKEISELRQQNDELTTLADEAQS----LKDEIDVLRHSSDKVS----KLEGQVESYKKK 326
L + + E + + L + ++ ++ + + +L+ ++K+ +LE +V +++
Sbjct: 792 LRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQ 851
Query: 327 LEDL-GD---LRRQVKLLEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRL 382
+EDL GD + +K E + + V +E ++A +AR LE ++ Q L
Sbjct: 852 IEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALEN---ELEAAQGNL 908
Query: 383 SEESKKADKLDFEYKRLKEKVDSLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGL 442
S+ +++ +L + K E+ + L++ K+ + ER L +TIE+L+ A + +
Sbjct: 909 SQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTST 968
Query: 443 MPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSD------NEKIALLQSLL 496
+ L +Q + + R +L +Q + K L E S +++ L++ L
Sbjct: 969 LELQNQ-------LDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEEL 1021
Query: 497 DDANLRKNELETENRLVNQRLLEVQSQVE----------ELQKSLQDQGSKAE------- 539
D ++E T+ +L+ Q L +++ ++E L K ++D+ S+ E
Sbjct: 1022 RDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEER 1081
Query: 540 -DSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLE-----PRFNNSSLK----------- 582
+S LL +++ E++ + NEL ++RA +DLE N LK
Sbjct: 1082 NNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYR 1141
Query: 583 -------------IEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPK------QN 623
I EL++ L +E + ++ ++ K K ++ +D + Q
Sbjct: 1142 SSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQK 1201
Query: 624 QGAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQREMEEK 663
+ ++A+K Q++E + LE K K QRE+EE+
Sbjct: 1202 DQLSLRLKAMKRQVEEAEEEIDRLES--SKKKLQRELEEQ 1239
Score = 72.4 bits (176), Expect = 1e-12
Identities = 82/401 (20%), Positives = 180/401 (44%), Gaps = 41/401 (10%)
Query: 311 DKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAARSQLET 370
+ S+++ +E K ++ +L+RQ++L ++N +++EE + A +L +
Sbjct: 604 NSTSEVKDLLEQKSKLTIEVAELQRQLQL-------EVKNQQNIKEERERMRANLEELRS 656
Query: 371 YKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRLRTE----RDSLKETIEE 426
+ VE + L + ++++ E ++ E++ ++ E+++ +TE +D L E +E
Sbjct: 657 QHNEKVEENSTLQQRLEESEG---ELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDE 713
Query: 427 LRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSDN 486
L + E + +G + ++ L ++ E +E L+R + +
Sbjct: 714 LDSAKRSEDR--EKGALIEELLQAKQDLQDLLIAKEEQEDLLRKR-------------ER 758
Query: 487 EKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSV---- 542
E AL +L ++ + E++ + L ++ VEE K+++ S++ S
Sbjct: 759 ELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQA 818
Query: 543 ---LLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQ 599
+ K L+E EKL + EL+++ + L+ + + + +E L+K E E++Q
Sbjct: 819 GTEMRVKLLQEENEKLQGRSEELERR---VAQLQRQIEDLKGDEAKAKETLKKYEGEIRQ 875
Query: 600 MEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQRE 659
+EE ++ K + +N+ A + L QE+ +L L++E E+ + R
Sbjct: 876 LEEALVHARKEEKEAVSARRALENELEAAQ-GNLSQTTQEQKQLSEKLKEESEQKEQLRR 934
Query: 660 MEEKYIVSAWYNMGMTLHKKAAEDRLASTGSGQSFLARQRQ 700
++ + W+ +G T+ K E S S L Q Q
Sbjct: 935 LKNEMENERWH-LGKTIEKLQKEMADIVEASRTSTLELQNQ 974
Score = 52.4 bits (124), Expect = 1e-06
Identities = 50/255 (19%), Positives = 127/255 (49%), Gaps = 18/255 (7%)
Query: 174 LDRQLKKTTEELNEALSAKEEIAQRCHELDMQVAA---LQEEKSSLLAENQVLMERLNQS 230
++ +L+ +EAL+ ++ + Q +L+ ++ A L++++S L+ + + + +L
Sbjct: 1017 MEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEME 1076
Query: 231 DSIEDPNSPA-GRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDEL 289
E NS R + + Q+EQL+ E + AA+ D LE++ +L+ + +
Sbjct: 1077 LEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSR---I 1133
Query: 290 TTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQ 349
L +S K+ + V + ++++LE ++ES ++ D +L+ + LE K +
Sbjct: 1134 IHLEGSYRSSKEGLVVQMEA--RIAELEDRLESEER---DRANLQLSNRRLERK---VKE 1185
Query: 350 NTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKE 409
+ +++E + QL ++ ++ ++ E ++ D+L+ K+L+ +++
Sbjct: 1186 LVMQVDDEHLSLTDQKDQLSL---RLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDM 1242
Query: 410 KDRLRTERDSLKETI 424
+ L+ + +S+K+ +
Sbjct: 1243 NEHLQGQLNSMKKDL 1257
Score = 39.7 bits (91), Expect = 0.010
Identities = 60/284 (21%), Positives = 117/284 (41%), Gaps = 35/284 (12%)
Query: 407 QKEKDRLRTERDSLKETIEELR-------CVQAQEGQLTTQG--LMPLGSQESSDSLAAE 457
Q+ + R + S+ T +L+ C ++ Q G L GSQES+ A
Sbjct: 427 QRPLSQERRGKQSVGRTFAKLQGAAHGASCAHSRPPQPNIDGKVLETEGSQESTVIRAPS 486
Query: 458 IVTPEIREKLIRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRL 517
+ +E+ ++ ML+ + + A S+ + N T + L Q+
Sbjct: 487 LGAQSKKEEEVKTATATLMLQNRATATSPDSGAKKISVKTFPSA-SNTQATPDLLKGQQE 545
Query: 518 LEVQSQVEELQKSLQD---QGSKAEDSVLLKKKLEEHLEKLH----------EANNELQK 564
L Q+ E ++ L + +GS D K+K+ EK+ + NN+
Sbjct: 546 LTQQTNEETAKQILYNYLKEGSTDNDDAT-KRKVNLVFEKIQTLKSRAAGSAQGNNQACN 604
Query: 565 KRAIIEDLEPRFNNSSLKIEELQEALR---KKEEEMKQMEERYKKYLEKAKSVIRTLDPK 621
+ ++DL + + ++++ ELQ L+ K ++ +K+ ER + LE+ +S
Sbjct: 605 STSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRS-------- 656
Query: 622 QNQGAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQREMEEKYI 665
Q+ E L+ +L+E + +E + K +RE + I
Sbjct: 657 QHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEI 700
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 100 bits (250), Expect = 4e-21
Identities = 140/651 (21%), Positives = 273/651 (41%), Gaps = 92/651 (14%)
Query: 96 NDFTLPDVNLIGEHSD-AAELGRMLQLILGCAVNCEQKQEYIQAIMMMEESVQHVVMTAI 154
+D D+N+ + ++ EL + +L+ E E + ++ + +Q V +
Sbjct: 1801 SDMPRNDINMWSKVTEEGTELSQ--RLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLL 1858
Query: 155 QELMSKESPVSAGNDAYVDLDRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKS 214
+ + S + +L R+ + +E E+L +EE+ +R HE L E S
Sbjct: 1859 EAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELS 1918
Query: 215 SL------LAENQVLMERLNQS-----DSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEA 263
A+ + L ER Q D +E A R +L+ + +Q+QEE L
Sbjct: 1919 KAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSR 1978
Query: 264 AKDDYRIRCEELEKE-ISELRQQNDELTTLADEAQSLKDEI--DVLRHSSDKVSKLEGQV 320
K+ + +E++ + E + E + +A+ ++D++ V D ++ +
Sbjct: 1979 QKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFI 2038
Query: 321 ESYKKKLEDLGDLRRQVKLLEE------------------KNTMYMQNTVSLEEELRKAN 362
E ++K +L DLR+Q + LE+ + ++ Q LE++L+
Sbjct: 2039 ELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVP 2098
Query: 363 AARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRLRTERDSLKE 422
+ E R+V +L N L E++ K +L ++L+ + +E ++L L++
Sbjct: 2099 RFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQ 2158
Query: 423 TIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQE 482
+ V A Q + G+ E+ L+ E+ R+ + R + E L+ E
Sbjct: 2159 AL----LVSADTFQ-KVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLE 2213
Query: 483 ------GSDNEKIALLQSLLD----DANLRKNELETENRLVNQRLLEVQSQVEELQ-KSL 531
+ NE++ L L+ ++ R ELE EN+L + ++ ++E S
Sbjct: 2214 QFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMST 2273
Query: 532 QDQ----GSKAEDSVLLKKKLE-----EHLEKLHEA------NNELQKKRAIIEDLEPRF 576
QDQ G A+ ++ +K++E E + KL + N +++K +I DLE +
Sbjct: 2274 QDQHVLFGKFAQ--IIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQI 2331
Query: 577 -----------NNSSLKIEELQEALRKKEEEMKQMEERYK----KYLEKAKSVIRTLD-- 619
N +IE+L E + K ++E+ + ++ E+A S+ LD
Sbjct: 2332 ECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVV 2391
Query: 620 -------PKQNQGAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQREMEEK 663
+Q + A E+ +KN L+E + + L +E K +RE EK
Sbjct: 2392 IAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEK 2442
Score = 100 bits (248), Expect = 6e-21
Identities = 116/533 (21%), Positives = 246/533 (46%), Gaps = 62/533 (11%)
Query: 168 NDAYVDLDRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERL 227
+D+Y + Q T E+ E+ E+A + HE++ L+E + + E ++
Sbjct: 142 DDSYSEQGAQDSPTHLEMMES-----ELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEF 196
Query: 228 NQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFR--LEAAKDDYRIRCEELEKEISELRQQ 285
+ D +LQ Q + ++ET R LE + +++ + + + SE +
Sbjct: 197 EAAIKQRDGIITQLTANLQ---QARREKDETMREFLELTEQSQKLQIQFQQLQASETLRN 253
Query: 286 NDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNT 345
+ +T AD Q+ + +L H ++ + + +E Y+KK ED Q+ L+EK
Sbjct: 254 STHSSTAADLLQAKQQ---ILTHQQ-QLEEQDHLLEDYQKKKEDF---TMQISFLQEKIK 306
Query: 346 MYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKK----------ADKL--- 392
+Y +E++ + N+ + +++ + + EL ++ EE KK ADKL
Sbjct: 307 VY-----EMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGE 361
Query: 393 --------DFEYKRLKEKVDSLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGL-- 442
+ E K +K ++ + ++++ + E L T+EEL+ ++ Q T +
Sbjct: 362 LQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQR 421
Query: 443 MPLGSQESSDSLAAEI------VTPEIREKLIRLQHENKMLKLNQEGSDNEKIALLQSLL 496
M +Q + L AE+ +++++LIR QH +M +E K + +L
Sbjct: 422 MEQETQRKLEQLRAELDEMYGQQIVQMKQELIR-QHMAQM----EEMKTRHKGEMENALR 476
Query: 497 DDANLRKNE--LETENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEK 554
+N+ NE ++ N +N+ +++Q + +K ++ G E+ L+++LE+ +E+
Sbjct: 477 SYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEE 536
Query: 555 LHEANNELQKKRAIIEDLEPRFN---NSSLKIEELQEALRKKEEEMKQMEERYKKYLEKA 611
L + ++Q+ R I + E + N S +E+L+ + E K++E +++ +
Sbjct: 537 LSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNY 596
Query: 612 KSVIRTLDPKQNQGAAPEIQALKNQLQE-RDRLFHSLEKEYEKTKSQREMEEK 663
K + L+ ++N ++ + +L+ R +L S E+E K K E+E +
Sbjct: 597 KIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHR 649
Score = 83.6 bits (205), Expect = 6e-16
Identities = 133/562 (23%), Positives = 242/562 (43%), Gaps = 65/562 (11%)
Query: 130 EQKQEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELNEAL 189
E K E +Q + M E + T +QEL + N + D +L +E ++A+
Sbjct: 2220 ENKNEEVQQLHMQLEIQKKESTTRLQELEQE-------NKLFKDDMEKLGLAIKE-SDAM 2271
Query: 190 SAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSDSIEDPNSPAGRRH---LQ 246
S +++ H L + A + +EK + + + +L Q I N ++
Sbjct: 2272 STQDQ-----HVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRD 2326
Query: 247 LQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADE----AQSLKDE 302
L+TQ+E L + E K + E+L + I +L+Q EL + + A SL +E
Sbjct: 2327 LETQIECLMSDQ---ECVKRNREEEIEQLNEVIEKLQQ---ELANIGQKTSMNAHSLSEE 2380
Query: 303 IDVLRHSSDKVSK----LEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEEL 358
D L+H D V LE QVE+ +++ + ++ ++ + T + + E +
Sbjct: 2381 ADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESV 2440
Query: 359 RKA-----NAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKE--KVDSLQKEKD 411
K N+ ++ + EL+ L+E++ K+ + +K +E K + E
Sbjct: 2441 EKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETR 2500
Query: 412 RLRTERDSLKETIEELRCVQA-----QEGQLTTQGLMP--LGSQESSDSLAAEIVTPEIR 464
L+ E + +E +C + ++GQ T+ L + Q+ + A + +I+
Sbjct: 2501 LLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQ 2560
Query: 465 EKLIRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQV 524
L +Q K + NQ S + +Q+L LR++EL ++ + R+ E++SQV
Sbjct: 2561 --LEAVQEYAKFCQDNQTISSEPERTNIQNL---NQLREDELGSDISALTLRISELESQV 2615
Query: 525 EELQKSL---QDQGSKAEDSVLLKKKLEEHLEKLHEANNELQK---KRAIIEDLEP---- 574
E+ SL ++Q AE +VL K+K L+KL E N + Q+ K+ +D+E
Sbjct: 2616 VEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTT 2675
Query: 575 ----RFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEI 630
N S EL EALR + K YK+ EK + + + ++
Sbjct: 2676 TELFHSNEESGFFNEL-EALRAESVATKAELASYKEKAEKLQEELLVKETNMT-SLQKDL 2733
Query: 631 QALKNQLQERDRLFHSLEKEYE 652
+++ L E LEKE E
Sbjct: 2734 SQVRDHLAEAKEKLSILEKEDE 2755
Score = 82.4 bits (202), Expect = 1e-15
Identities = 124/577 (21%), Positives = 246/577 (42%), Gaps = 58/577 (10%)
Query: 130 EQKQEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELNEAL 189
+ KQE I+ M E ++ ++ + S ++ D Q+K +NE
Sbjct: 447 QMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNED-------QIKLMNVAINELN 499
Query: 190 SAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSDSIEDPNSPAGRRHLQLQT 249
++ + +L ++ + EEK +L + + L+E L+ S Q+Q
Sbjct: 500 IKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSRE-------------QIQR 546
Query: 250 QLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEAQSLKDEIDVLRHS 309
+ + E+ +L A E+L+ EI + EL L EA+ +I +
Sbjct: 547 ARQTIAEQESKLNEAHKSLS-TVEDLKAEIVSASESRKEL-ELKHEAEVTNYKIKLEMLE 604
Query: 310 SDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAARSQLE 369
+K + L+ ES + +LE LR Q+ E+ ++ + +E + +
Sbjct: 605 KEKNAVLDRMAESQEAELE---RLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGI 661
Query: 370 TYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRLRTERDSLKETIEELRC 429
YK+Q+ LQN E S+K + + FE L K + L E +L+ + SL + E
Sbjct: 662 HYKQQIDGLQN---EMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMT 718
Query: 430 VQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSDNEKI 489
+Q E Q + L ++ +L E+ +++ +L+ Q + K E EK
Sbjct: 719 LQINELQKEIEILRQ--EEKEKGTLEQEVQELQLKTELLEKQMKEK------ENDLQEKF 770
Query: 490 ALLQSLLDDANLRKNELETENRLVNQRLLEVQSQV--EELQKSLQDQGSKAEDSV----- 542
A L++ +N + + + + +L++ + V EE L SK++DSV
Sbjct: 771 AQLEA--------ENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEI 822
Query: 543 -LLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQME 601
+L ++ E+ ++ + N E++K+R E F + +++E L K +++++ +
Sbjct: 823 EILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLE--D 880
Query: 602 ERYKKYLEKAKSVIRTLDPKQN-QGAAPEIQALKNQLQERDRLF--HSLEKEYEKTKSQR 658
+ K+ LE KS ++ L+ + + Q P +K+ + + D+ F +LE K
Sbjct: 881 SKNKQELE-YKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTT 939
Query: 659 EMEEKYIVSAWYNMGMTLHKKAAEDRLASTGSGQSFL 695
E+ EK V+ + ++ ++L SFL
Sbjct: 940 ELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFL 976
Score = 72.8 bits (177), Expect = 1e-12
Identities = 135/621 (21%), Positives = 275/621 (44%), Gaps = 89/621 (14%)
Query: 34 DLTNGVVMAQVLQKIDPAYFD------ENWLNRIKTEVGDNWRLKISNLKKILKGILDYN 87
++TN + ++L+K A D E L R++T++ + ++S LK+ L +
Sbjct: 592 EVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDL----EIE 647
Query: 88 HEILGQQINDFTLPDVNLIGEHSDAAELGRMLQLILGCAVNCEQKQEYIQAIMMMEESVQ 147
H I +++ D +G H Q I G QK E +Q + Q
Sbjct: 648 HRINIEKLKDN-------LGIHYK--------QQIDGLQNEMSQKIETMQFEKDNLITKQ 692
Query: 148 HVVMTAIQELMS-KESPVSAGNDAYVDLDRQLKKTTEELNEALSAKEEIAQRCHELDMQV 206
+ ++ I +L ++S V++ ++ +L+K E L + K + Q EL ++
Sbjct: 693 NQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKT 752
Query: 207 AAL-----------QEEKSSLLAENQVLMERLNQSDSIEDPNSPAGRRH-------LQLQ 248
L QE+ + L AEN +L + + + ++P + ++ +
Sbjct: 753 ELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSK 812
Query: 249 TQLEQLQEETFRLEAAKDDYRIRCEELEKEISELR------QQNDELTTLADEAQSLKDE 302
++ ++E L +D + +C +L +EI + R ++N E+ Q L++E
Sbjct: 813 SKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNY-----QELQEE 867
Query: 303 IDVLRHSSDKVSKLEGQVE-SYKKKLEDLGD-----------LRRQVKLLEEKNTMYMQN 350
L D + + + E YK KL+ L + ++ + + +E T ++
Sbjct: 868 YACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKT-FVAE 926
Query: 351 TVSLEEELRK-ANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKE 409
T+ + E + K +LE KR+ +EL RLS+ S++ + E L E+V SL++E
Sbjct: 927 TLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQE 986
Query: 410 KDRLRTERDSLKETIEELRC--VQAQEGQLTT--QGLMPLGSQESSDSLAAEIVTPEIRE 465
K+++ L+ I R VQ+ + Q+++ G++ + S+ + S++ V E
Sbjct: 987 KEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSK--VNKSFGE 1044
Query: 466 KLIRLQHENKMLKLNQ---EGSDNEKIAL--LQSLLDDANLRKNELETENRLVNQRLLEV 520
+ ++ E+K+ N E S E++ L L S+ +++LR + +EN + + L +
Sbjct: 1045 E-SKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQ-PSENDKLQKELNVL 1102
Query: 521 QSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSS 580
+S+ +L+ ++ Q + L H++++ E E +K +A+ E
Sbjct: 1103 KSEQNDLRLQMEAQ------RICLSLVYSTHVDQVRE-YMENEKDKALCSLKEELIFAQE 1155
Query: 581 LKIEELQEALRKKEEEMKQME 601
KI+ELQ+ + + + MK E
Sbjct: 1156 EKIKELQKIHQLELQTMKTQE 1176
Score = 67.4 bits (163), Expect = 4e-11
Identities = 97/488 (19%), Positives = 210/488 (43%), Gaps = 65/488 (13%)
Query: 246 QLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEAQS-LKDEID 304
+LQ +E+L E + + ++ EL +E +Q+ E +E + L +E
Sbjct: 1849 RLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESR 1908
Query: 305 VLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVS-LEEELRKANA 363
+ ++SK EG ++ Y + K L E+ + + LE+EL A+
Sbjct: 1909 AREQLAVELSKAEGVIDGYADE-----------KTLFERQIQEKTDIIDRLEQELLCASN 1957
Query: 364 ARSQLETYKRQVVELQNRLS--EESKKADKLDFEYKRLKEKVDSLQKEKDRLRTE----R 417
+LE ++Q+ E + LS +E+ KA+ E + L+E + L KEK ++ + R
Sbjct: 1958 RLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQE-TEKLMKEKLEVQCQAEKVR 2016
Query: 418 DSLKETIEEL---------RCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLI 468
D L++ ++ L R ++ ++ + T LM L Q + E + + E+ I
Sbjct: 2017 DDLQKQVKALEIDVEEQVSRFIELEQEKNTE--LMDLRQQNQALEKQLEKMRKFLDEQAI 2074
Query: 469 RLQHENKMLKLNQEGSDNEK--IALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEE 526
+HE + + + + + + Q + + +L + + E+ E+
Sbjct: 2075 DREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQ 2134
Query: 527 LQKSLQDQGSKAEDSVLLKKKLEEHL-------EKLHEANN--------------ELQKK 565
LQ+ +Q++ + E ++LE+ L +K+ + + +LQ +
Sbjct: 2135 LQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAE 2194
Query: 566 RAIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQ-NQ 624
R I+ E N ++E+ +E L K EE++Q+ + + ++K +S R + +Q N+
Sbjct: 2195 RDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLE--IQKKESTTRLQELEQENK 2252
Query: 625 GAAPEIQALKNQLQERDRLF----HSLEKEYEKTKSQREME----EKYIVSAWYNMGMTL 676
+++ L ++E D + H L ++ + ++E+E + + + +T
Sbjct: 2253 LFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITT 2312
Query: 677 HKKAAEDR 684
K E++
Sbjct: 2313 DNKVIEEK 2320
Score = 65.9 bits (159), Expect = 1e-10
Identities = 77/411 (18%), Positives = 197/411 (47%), Gaps = 47/411 (11%)
Query: 297 QSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEE 356
+++ + L H+ KV++ E ES+++K E L+ Q +L E + + + + E+
Sbjct: 1859 EAISETSSQLEHA--KVTQTELMRESFRQKQEATESLKCQEELRERLH----EESRAREQ 1912
Query: 357 ELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRLRTE 416
+ + A ++ Y + + ++ E++ D+L+ E ++ L+ E+ +++ E
Sbjct: 1913 LAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEE 1972
Query: 417 RDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIR--LQHEN 474
R+ L E ++ A+ G + Q L + ++ L E + + + + +R LQ +
Sbjct: 1973 RELLSRQKEAMK---AEAGPVEQQLL------QETEKLMKEKLEVQCQAEKVRDDLQKQV 2023
Query: 475 KMLKLNQEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQ 534
K L+++ E E+++ L + N +L +N+ + ++L +++ ++E + +
Sbjct: 2024 KALEIDVE----EQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHE 2079
Query: 535 GSKAEDSVLLKKKLEEHLEKL-------HEANNELQKKRAIIEDLEPRFNNSSLKIEELQ 587
+ + +KLE+ L+ + E+++ +++ + + L E+LQ
Sbjct: 2080 RDVFQQEI---QKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQ 2136
Query: 588 EALRKKEEEMKQMEERYKKYLEKAKSV----IRTLDPKQNQGAAP---------EIQALK 634
++++ EE++++E R ++ LE+A V + ++ +++ GA ++QA +
Sbjct: 2137 RDIQERNEEIEKLEFRVRE-LEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAER 2195
Query: 635 NQLQERDRLFHSLEKEYEKTKSQREMEEKYIVSAWYNMGMTLHKKAAEDRL 685
+ + +++ +LE++ E+ + E+E K +M + + KK + RL
Sbjct: 2196 DAIDRKEKEITNLEEQLEQFR--EELENKNEEVQQLHMQLEIQKKESTTRL 2244
Score = 65.1 bits (157), Expect = 2e-10
Identities = 129/639 (20%), Positives = 247/639 (38%), Gaps = 81/639 (12%)
Query: 83 ILDYNHEILGQQINDFTLPDVNLIGEHSDAAELGRMLQLILGCAVNCEQKQEYIQAIMMM 142
+L+YN + Q+ + V L A EL QL V E K E Q + +
Sbjct: 3121 LLEYN---IQQKQSQMLEMQVELSSMKDRATELQE--QLSSEKMVVAELKSELAQTKLEL 3175
Query: 143 EESV--QHVVMTAIQ----ELMSKESPVSAGNDAYVDLDRQLKKTTEELNEALSAKEEIA 196
E ++ QH + ++ E+ K V ND +K + EL AL ++
Sbjct: 3176 ETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASE----QKKSRELQWALEKEKAKL 3231
Query: 197 QRCHELDMQVAALQEEKSSLLAENQ------VLMERLNQSDSIEDPNSPAGRRHLQLQTQ 250
R E D + L++ K SL ++ Q +L+E+ Q + + + + Q
Sbjct: 3232 GRSEERDKE--ELEDLKFSLESQKQRNLQLNLLLEQ--QKQLLNESQQKIESQRMLYDAQ 3287
Query: 251 LEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEAQS---------LKD 301
L + Q L+ + ++R E+ + R+ + +L + QS LK+
Sbjct: 3288 LSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKE 3347
Query: 302 EIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKA 361
L ++ +L + E YK L+ L Q + EK+ + T+ E+E
Sbjct: 3348 LQKQLEEKHSRIVELLNETEKYK--LDSL-----QTRQQMEKDRQVHRKTLQTEQEAN-- 3398
Query: 362 NAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQK---EKDRLRTERD 418
+ ++ + +V +LQ +L E+ ++ KLD E +RL+ + QK E++ R R
Sbjct: 3399 TEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRR 3458
Query: 419 SLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPE------------IREK 466
L + + E + L E+ +S A+++ IR+K
Sbjct: 3459 ILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQK 3518
Query: 467 L------IRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEV 520
L +++ + +L E +D+E +Q +D+ L+ Q+L
Sbjct: 3519 LQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQL-----------QKLTGQ 3567
Query: 521 QSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSS 580
Q + L GS E + +L H+ +L E N+L+ +E+ + +
Sbjct: 3568 QGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTG 3627
Query: 581 LKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQER 640
+ ++ + K+ + K ++ K + A E+ LK +L+
Sbjct: 3628 AGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQ----KSLKRAEAEVYKLKAELR-N 3682
Query: 641 DRLFHSLEKEYEKTKSQREMEEKYIVSAWYNMGMTLHKK 679
D L +L + E +R + KY+ + + + KK
Sbjct: 3683 DSLLQTLSPDSEHVTLKR-IYGKYLRAESFRKALIYQKK 3720
Score = 57.4 bits (137), Expect = 5e-08
Identities = 108/521 (20%), Positives = 208/521 (39%), Gaps = 97/521 (18%)
Query: 142 MEESVQHVVMTAIQELMS-KESPVSAGNDAYVDLDRQLKKTTEELNEALSAKEEIAQRCH 200
M QHV+ +++ KE + N+ L +QLK TT+ N+ + K E+ +
Sbjct: 2271 MSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTD--NKVIEEKNELIR--- 2325
Query: 201 ELDMQVAALQEEKSSLLAENQVLMERLNQ--------------------------SDSIE 234
+L+ Q+ L ++ + + +E+LN+ +DS++
Sbjct: 2326 DLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLK 2385
Query: 235 DPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLA- 293
L L+ Q+E EE ++ + + +L +E+ L+++ + + +
Sbjct: 2386 HQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQS 2445
Query: 294 ----------DEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGD---LRRQVKLL 340
D K E++V+ + D + LE Q +Y K E+ G + + +LL
Sbjct: 2446 IPENSVNVAIDHLSKDKPELEVVL-TEDALKSLENQ--TYFKSFEENGKGSIINLETRLL 2502
Query: 341 EEKNTMYMQN---TVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYK 397
+ ++T+ ++ T ++ + + E ++++V LQ + E+ A + +
Sbjct: 2503 QLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLE 2562
Query: 398 RLKEKVDSLQKEKDRLRTERDSLKETIEELRCVQAQEGQL------TTQGLMPLGSQ--E 449
++E Q D + + I+ L Q +E +L T + L SQ E
Sbjct: 2563 AVQEYAKFCQ---DNQTISSEPERTNIQNLN--QLREDELGSDISALTLRISELESQVVE 2617
Query: 450 SSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSDNEK-------------IALLQSLL 496
SL E EI EK + L+ E K+L+L + NEK + +L++
Sbjct: 2618 MHTSLILEKEQVEIAEKNV-LEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTT 2676
Query: 497 DDANLRK-----NELET---ENRLVNQRLLEVQSQVEELQK----------SLQDQGSKA 538
+ + + NELE E+ L + + E+LQ+ SLQ S+
Sbjct: 2677 ELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQV 2736
Query: 539 EDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNS 579
D + K+ LEK E + KK + E L + + S
Sbjct: 2737 RDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKS 2777
Score = 46.6 bits (109), Expect = 8e-05
Identities = 149/728 (20%), Positives = 286/728 (39%), Gaps = 138/728 (18%)
Query: 30 QTVEDLTNGVVMAQVLQKIDPAYFDENWLNRIKTEVGDNWRLKISNLKKILKGILDYNHE 89
Q ++ L N ++ QKI+ F+++ L + ++ L+IS LK + + +++ E
Sbjct: 665 QQIDGLQN-----EMSQKIETMQFEKDNLITKQNQL----ILEISKLKDLQQSLVNSKSE 715
Query: 90 ILGQQINDFTLPDVNLIGEHSDAAELGRMLQ-LILGCAV---NCEQKQEYIQ---AIMMM 142
+ QIN+ L E + L + +Q L L + ++K+ +Q A +
Sbjct: 716 EMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEA 775
Query: 143 EESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTE-----ELNEALSAKEEIAQ 197
E S+ +++++ +PVS + + LD K+ + E+ + E++ Q
Sbjct: 776 ENSILKDEKKTLEDMLKIHTPVSQ-EERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQ 834
Query: 198 RCHELDMQVAA------------------LQEE----------------------KSSLL 217
+C +L+ ++ LQEE KS L
Sbjct: 835 QCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLK 894
Query: 218 AENQVL-MERLNQS-----DSIEDPNSPAGRRHLQLQTQLEQLQEETF-RLEAAKDDYRI 270
A N+ L ++R+N + S+ D + L++ +E+ E +LE K +
Sbjct: 895 ALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLE 954
Query: 271 RCEELEKEISELRQQNDELTTLADEAQSLKDEID-----------VLRHS-SDKVSKLEG 318
+ L +L+Q++ E++ L +E +SLK E + ++ H+ ++ V +
Sbjct: 955 LSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDT 1014
Query: 319 QVESYKKKLEDL------GDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAARSQLETYK 372
QV S + + G + + K E++ + +++ VS E + + QL
Sbjct: 1015 QVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDH 1074
Query: 373 RQVVELQNRL-SEESKKADKLDFEYKRLKEKVDSLQKEKDRLR--------TERDSLKET 423
V ++ L + + + DKL E LK + + L+ + + R T D ++E
Sbjct: 1075 LPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREY 1134
Query: 424 IEELR----------CVQAQEGQLTTQG------LMPLGSQESSDS---------LAAEI 458
+E + + AQE ++ L + +QE+ D +
Sbjct: 1135 MENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKA 1194
Query: 459 VTPEIREKLIRL-----QHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELETENRLV 513
V+ E L L ++ LK D E S +D L+ E ++
Sbjct: 1195 VSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQE 1254
Query: 514 NQRLLEVQSQVEELQKSL--QDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIED 571
N L + EE K L Q + SK KLE E L + E + + +
Sbjct: 1255 NMHTL-LNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTN 1313
Query: 572 LEPRFNNSSLKIEELQEALRKK-EEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEI 630
LE N K+ LQ+ + K EE+++++E ++ K + +QN A EI
Sbjct: 1314 LEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLK------ETEQNYEA--EI 1365
Query: 631 QALKNQLQ 638
L+ +LQ
Sbjct: 1366 HCLQKRLQ 1373
Score = 46.6 bits (109), Expect = 8e-05
Identities = 64/258 (24%), Positives = 112/258 (43%), Gaps = 35/258 (13%)
Query: 414 RTERDSLKET--IEELRCVQA--QEGQLTTQGLMPLGSQESSDSLAAEI--VTPEIREKL 467
RTE +L T + L C++ QE + Q M + SL +EI + ++ +
Sbjct: 3046 RTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRK 3105
Query: 468 IRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQ---- 523
I L+ E + K +QE LL+ + + E++ E + R E+Q Q
Sbjct: 3106 ITLKREQESEKPSQE--------LLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSE 3157
Query: 524 ---VEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSS 580
V EL+ L + E ++ K +HL++L E++ K + L +
Sbjct: 3158 KMVVAELKSELAQTKLELETTL---KAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQ 3214
Query: 581 LKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQER 640
K ELQ AL K++ ++ + EER K+ LE K + + + Q L L+++
Sbjct: 3215 KKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQ--------LNLLLEQQ 3266
Query: 641 DRLFHSLEKEYEKTKSQR 658
+L L + +K +SQR
Sbjct: 3267 KQL---LNESQQKIESQR 3281
Score = 45.1 bits (105), Expect = 2e-04
Identities = 101/417 (24%), Positives = 175/417 (41%), Gaps = 61/417 (14%)
Query: 167 GNDAYVDLDRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMER 226
G + ++L+ +L +L +SAK+ +C++ Q+ +QE+ E ++L ++
Sbjct: 2490 GKGSIINLETRLL----QLESTVSAKDLELTQCYK---QIKDMQEQGQF---ETEMLQKK 2539
Query: 227 LNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQ-Q 285
+ I + A L Q QLE +QE + +D+ I E I L Q +
Sbjct: 2540 IVNLQKIVEEKVAAA---LVSQIQLEAVQEYA---KFCQDNQTISSEPERTNIQNLNQLR 2593
Query: 286 NDEL----TTLADEAQSLKDEIDVLRHSS-----DKVSKLEGQVESYKKKLEDLGDL--- 333
DEL + L L+ ++ V H+S ++V E V +KKL +L L
Sbjct: 2594 EDELGSDISALTLRISELESQV-VEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEG 2652
Query: 334 -RRQVKLLEEKNTMYMQNTVSLEEELRKANAAR---SQLETYKRQVVELQNRLSEESKKA 389
++ + E+K + + EL +N ++LE + + V + L+ +KA
Sbjct: 2653 NEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKA 2712
Query: 390 DKLDFEYKRLKEKVDSLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLM----PL 445
+KL E + + SLQK+ ++R KE + L E Q + + M P+
Sbjct: 2713 EKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPI 2772
Query: 446 GSQESSDS-------LAAEIVTPEIREK----LIRLQHENKMLKLNQEGSD-NEKIALLQ 493
+S S +++ TP+I K I LQ E ++ + S EKI +Q
Sbjct: 2773 KLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQ 2832
Query: 494 SL-----LDDANLRKNELETENRLVNQRLLEVQSQVEE---LQKSLQDQGSKAEDSV 542
L LD + +E ET L + + VQ EE L+ +Q SK S+
Sbjct: 2833 ELHAAEILDMESRHISETET---LKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSI 2886
>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo
sapiens]
Length = 1116
Score = 100 bits (249), Expect = 5e-21
Identities = 128/585 (21%), Positives = 249/585 (42%), Gaps = 86/585 (14%)
Query: 142 MEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELNEALSAKEEIAQRCHE 201
+EE +Q + +E + + Y + +K E+L E LS+KE + E
Sbjct: 401 LEEEIQMLKSNGALSTEEREEEMKQ-MEVYRSHSKFMKNKVEQLKEELSSKEA---QWEE 456
Query: 202 LDMQVAALQEE----KSSLLAENQVLMERLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEE 257
L + A LQ E K L ++ L+ + +++ + S + + L+ L ++
Sbjct: 457 LKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQR 516
Query: 258 TFRLEAAKDDYRIRCEE----LEKEISELRQQNDELTTLADEAQSLKDEIDVLRHSSDKV 313
L+ D R+R EE L K+ +++ +E T A E LKD +DV KV
Sbjct: 517 AAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKER---KV 573
Query: 314 SKLEGQVESYKKKLED----LGDLRRQVKLLEEKNTMYMQNTVSLEEEL----------- 358
+ L+ ++E+ +++L D + L+ +VK L+ T +LEE L
Sbjct: 574 NVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLK 633
Query: 359 ----RKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQ----KEK 410
R + +++ YK+ + +L+ ++S + + LKE SL K+
Sbjct: 634 EQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKD 693
Query: 411 DRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSD---------------SLA 455
RL+T +L++ EE +++Q + L S E SD S
Sbjct: 694 SRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSK 753
Query: 456 AEIVTPEIREKLIRLQHEN-----KMLKLNQEGSD-NEKIALLQ-----------SLLDD 498
A+ + E L +++E K+ +L ++ D N+K+A L+ +L++
Sbjct: 754 AQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEE 813
Query: 499 ANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQGS-KAEDSVLL----------KKK 547
A R++ L ++ + L + ++EEL+++L++ AE ++L +K+
Sbjct: 814 ARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQ 873
Query: 548 LEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQMEER--YK 605
+EE L + + EL+ +A + + + L+ RK EE+ +M++
Sbjct: 874 VEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLA 933
Query: 606 KYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRLFHSLEKE 650
EK ++ + E+ ALK +E+DRL L+++
Sbjct: 934 AISEKDANIALLELSSSKKKTQEEVAALK---REKDRLVQQLKQQ 975
Score = 89.0 bits (219), Expect = 1e-17
Identities = 134/617 (21%), Positives = 261/617 (42%), Gaps = 92/617 (14%)
Query: 175 DRQLKKTTEEL-NEALSAK-----EEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLN 228
D +KK E L ++ LSAK E +R E +M V L+ EN +L E ++
Sbjct: 306 DESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMH 365
Query: 229 QSDSIEDPNSPAGRRHLQLQTQLEQ-----------LQEETFRLEAAKDDYRIRCEELEK 277
+ N+P + LQT +E L++ ++ K + + EE E+
Sbjct: 366 RRFE----NAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREE 421
Query: 278 EISELRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSK----LEGQVESYKK-------- 325
E+ ++ + ++ + LK+E+ +++ K L+ ++ K+
Sbjct: 422 EMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTE 481
Query: 326 ------KLEDL----GDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAARSQLET-YKRQ 374
KLE L D ++ +++L+E T Q L+ E+ + ET ++
Sbjct: 482 LLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKK 541
Query: 375 VVELQNRLSEESKKA-------DKLDFEYKR---LKEKVDSLQKEKDRLRTERDSLKETI 424
++Q+ E+ +A D LD + ++ L++K+++LQ++ + SLKE +
Sbjct: 542 TKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERV 601
Query: 425 EELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQE-- 482
+ L+ T L +E + E + REK + + K LK +E
Sbjct: 602 KSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKV 661
Query: 483 ----GSDNEKIALLQSLLDDA-NLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQGSK 537
G +EK A L L + A +L + L+ ++RL + Q + E L+ ++ Q K
Sbjct: 662 SLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLK--MESQLKK 719
Query: 538 AEDSVL--------------LKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKI 583
A ++ L L++++ + ++ +A E+ + I++++E N+ KI
Sbjct: 720 AHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKI 779
Query: 584 EELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQ-GAAPEIQALKNQLQERDR 642
EL+ + K++ K ++K+ +EK KS + ++ + Q L++ L+++D
Sbjct: 780 AELERQV--KDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDD 837
Query: 643 LFHSLE---KEYEKTKSQREMEEKYIVSAWYN---------MGMTLHKKAAEDRLASTGS 690
LE +E + ++REM SA N M M K+ E A S
Sbjct: 838 RIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSS 897
Query: 691 GQSFLARQRQATSSRRS 707
Q LA + ++ R+
Sbjct: 898 TQQSLAEKETHLTNLRA 914
Score = 80.5 bits (197), Expect = 5e-15
Identities = 129/538 (23%), Positives = 230/538 (42%), Gaps = 101/538 (18%)
Query: 130 EQKQEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELNEAL 189
E+ Q I +++ ++ + + +L ++S G +L TEE + L
Sbjct: 220 EENQHMQMTIQALQDELR--IQRDLNQLFQQDSSSRTGEPCVAEL-------TEENFQRL 270
Query: 190 SAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSDSIEDPNSPAGRRHLQLQT 249
A+ E ++ EL + L+E + + + Q L R +SI+ + L +
Sbjct: 271 HAEHE--RQAKELFLLRKTLEEMELRIETQKQTLNAR---DESIKKLLEMLQSKGLSAKA 325
Query: 250 QLEQLQEETFRLEAAK---DDYRIRCEELEKEISELRQQNDELTTLADEAQSLKDEIDVL 306
E+ E T RL A+ E+ EKE S LR++ A ++ K V+
Sbjct: 326 T-EEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVI 384
Query: 307 RHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAARS 366
K+S +E L DL ++++L+ + +T EEE+++ RS
Sbjct: 385 EMKDSKISSME----------RGLRDLEEEIQMLKSNGAL---STEEREEEMKQMEVYRS 431
Query: 367 QLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRLRTERDSLKETIEE 426
+ K +V +L+ LS SK+A +++ LK+K LQ E +++ E S K+T E
Sbjct: 432 HSKFMKNKVEQLKEELS--SKEA-----QWEELKKKAAGLQAEIGQVKQEL-SRKDT--E 481
Query: 427 LRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSDN 486
L +Q + LT Q SDS ++ I + E+ K
Sbjct: 482 LLALQTKLETLTNQ---------FSDS-----------KQHIEVLKESLTAK-------E 514
Query: 487 EKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKK 546
++ A+LQ+ +D LR E ET ++N++ ++Q EE +G++A + LK
Sbjct: 515 QRAAILQTEVDALRLRLEEKET---MLNKKTKQIQDMAEE-------KGTQAGEIHDLKD 564
Query: 547 KLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKK 606
L+ K+ N LQKK IE LQE LR KE++M ++ER K
Sbjct: 565 MLDVKERKV----NVLQKK-----------------IENLQEQLRDKEKQMSSLKERVKS 603
Query: 607 YLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQ-REMEEK 663
L+ + T + A + + ++ ++RDR ++E + K ++++EK
Sbjct: 604 -LQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEK 660
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 100 bits (248), Expect = 6e-21
Identities = 122/525 (23%), Positives = 235/525 (44%), Gaps = 76/525 (14%)
Query: 192 KEEIAQ---RCHELDMQVAALQEEKSSLL----AENQVLMERLNQSDSIEDPNSPAGRRH 244
KEE+A+ R EL+ ++ +L +EK+ L +E + LM+ + + + +
Sbjct: 864 KEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSKILLEAKV 923
Query: 245 LQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELR----QQNDELTTLADEAQSLK 300
+L +LE+ +E L A K + +C L+++I +L + E ++ ++L
Sbjct: 924 KELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLS 983
Query: 301 DEIDVLRHSSDKVSKLEGQV-ESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELR 359
+E+ L + K++K + + E++++ L+DL +V L + N Q T LE L
Sbjct: 984 EEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLE 1043
Query: 360 KANAARSQLETYKRQ-----------VVELQNRLSEESKKADKLDFEYKRLKEKVD---- 404
+ R+ LE KR+ +++L+N + +K K +FE +L+ K+D
Sbjct: 1044 QEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQV 1103
Query: 405 ---SLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGS-----QESSDSLAA 456
QK+ L+ + L+E IE ++A+ + + L +E+S + +A
Sbjct: 1104 HSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSA 1163
Query: 457 EIVTPEIRE----KLIR------LQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNEL 506
+I + RE K+ R LQHE L ++ +D+ +A L +D+ K +L
Sbjct: 1164 QIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADS--VAELGEQIDNLQRVKQKL 1221
Query: 507 ETENRLVNQRLLEVQSQVEELQKS----------LQDQGSKAEDSVLLKKKLEEHLEKLH 556
E E + + ++ S +E L KS ++DQ S+ +K K E+ + +H
Sbjct: 1222 EKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSE------IKAKDEQQTQLIH 1275
Query: 557 EANNELQKKRAIIEDLEPRFNNSSLKIEEL---QEALRKKEEEMK-QMEERYKKYLEKAK 612
+ N + + + +L R I +L ++AL ++ EE+K QMEE K A
Sbjct: 1276 DLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAH 1335
Query: 613 SVIRTLDPKQNQGAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQ 657
++ Q + + L+ Q +E L++ K S+
Sbjct: 1336 AL---------QSSRHDCDLLREQYEEEQEAKAELQRALSKANSE 1371
Score = 94.7 bits (234), Expect = 3e-19
Identities = 131/510 (25%), Positives = 222/510 (43%), Gaps = 76/510 (14%)
Query: 182 TEELNEALSAKEEIAQRCHELD-------MQVAALQEEKSSLLAENQVLMERLNQSDSIE 234
TEEL EA K+++AQR E + + A+L++ K L E + LM L +S +
Sbjct: 1387 TEELEEA---KKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTAC 1443
Query: 235 DPNSPAGRRHLQLQTQLEQ-LQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLA 293
R ++ + +Q L E LEAA+ + R EL K + + D+L TL
Sbjct: 1444 ATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLR 1503
Query: 294 DEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLE-DLGDLRRQVKLLEEKNTMYMQNTV 352
E ++L++EI L + K + E KK +E + DL QV L E +
Sbjct: 1504 RENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDL--QVALEEVEG-------- 1553
Query: 353 SLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDR 412
SLE E K + +L K EL ++ E+ ++ ++L +R E + S+ + R
Sbjct: 1554 SLEHEESKILRVQLELSQVKS---ELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIR 1610
Query: 413 LRTERDSLKETIE-------------ELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIV 459
R + LK+ +E + + Q+ T QG + D+L +
Sbjct: 1611 SRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRS--- 1667
Query: 460 TPEIREKLIRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLE 519
+++E+L ++ N +L E + K+AL Q+ E RL Q LL+
Sbjct: 1668 NEDLKEQLAIVERRNGLL---LEELEEMKVALEQT------------ERTRRLSEQELLD 1712
Query: 520 VQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLH-EANNELQKKRAIIEDLEPRFNN 578
+V+ L S+ + KKKLE + + E N +Q+ R E + +
Sbjct: 1713 ASDRVQLLH-------SQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITD 1765
Query: 579 SSLKIEELQEALRKKEEEMKQMEERYKKYLEK-AKSVIRTLDPKQN---QGAAPEIQALK 634
+++ EEL KKE++ ER KK LE+ K + LD + +G +IQ L+
Sbjct: 1766 AAMMAEEL-----KKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLE 1820
Query: 635 NQLQERDRLFHSLEKEYEKTKSQREMEEKY 664
N+++E L + L+ E ++ + KY
Sbjct: 1821 NRVRE---LENELDVEQKRGAEALKGAHKY 1847
Score = 93.2 bits (230), Expect = 8e-19
Identities = 130/586 (22%), Positives = 256/586 (43%), Gaps = 91/586 (15%)
Query: 130 EQKQEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELNEAL 189
E K + + + EE + ++ + L K S + D DL+ L K +E +
Sbjct: 920 EAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDID---DLELTLTKVEKEKHATE 976
Query: 190 SAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERL----NQSDSIEDPNSPAGRRHL 245
+ + +++ L+ ++ L +EK SL +Q ++ L ++ + + N+ ++
Sbjct: 977 NKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTD 1036
Query: 246 QLQTQLEQLQEETFRLEAAK----DDYRIRCEELEKEISELRQQNDELTTLADEAQSLKD 301
L+ LEQ ++ LE AK D ++ E + ++ +Q ++L E L+
Sbjct: 1037 DLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQA 1096
Query: 302 EIDVLR-HS---SDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEE 357
+ID + HS K+ +L+ ++E ++++E LR ++ E++ + + + E
Sbjct: 1097 KIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKI---EKQRSDLARELEEISER 1153
Query: 358 LRKANAARS-QLETYKRQVVELQ--NRLSEES-------------KKADKLDFEYKRLKE 401
L +A+ A S Q+E K++ E Q R EE+ K+AD + L E
Sbjct: 1154 LEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSV----AELGE 1209
Query: 402 KVDSLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTP 461
++D+LQ+ K +L E+ LK I+++ + L +S+ V
Sbjct: 1210 QIDNLQRVKQKLEKEKSELKMEIDDM-----------ASNIEALSKSKSNIERTCRTVED 1258
Query: 462 EIREKLIRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQ 521
+ E I+ + E + L+ D N++K L+T+N ++ R+ E +
Sbjct: 1259 QFSE--IKAKDEQQ-----------------TQLIHDLNMQKARLQTQNGELSHRVEEKE 1299
Query: 522 SQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSL 581
S + +L KS Q + E+ LK+++EE + + + LQ R + L ++
Sbjct: 1300 SLISQLTKSKQALTQQLEE---LKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQE 1356
Query: 582 KIEELQEALRKKEEEMKQMEERYK-------KYLEKAKSVI--RTLDPKQNQGAA----P 628
ELQ AL K E+ Q +Y+ + LE+AK + R + ++N A
Sbjct: 1357 AKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCA 1416
Query: 629 EIQALKNQLQ-ERDRLFHSLEKEYEK----TKSQREMEEKYIVSAW 669
++ K +LQ E + L LE+ + K QR ++ +++ W
Sbjct: 1417 SLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDK--VLAEW 1460
Score = 87.8 bits (216), Expect = 3e-17
Identities = 115/558 (20%), Positives = 234/558 (41%), Gaps = 59/558 (10%)
Query: 134 EYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELNEALSAKE 193
E I + +++ ++ E+ S + A + + +++R + ++ +E + E
Sbjct: 1209 EQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDE 1268
Query: 194 EIAQRCHELDMQVAALQEEKSSL---LAENQVLMERLNQSDSIEDPNSPAGRRHLQLQTQ 250
+ Q H+L+MQ A LQ + L + E + L+ +L +S QL+
Sbjct: 1269 QQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQ---------QLEEL 1319
Query: 251 LEQLQEETFRLEA---AKDDYRIRCEELEKEISELRQQNDELTTLADEAQSLKDEIDVLR 307
Q++EET A A R C+ L ++ E ++ EL +A S + +
Sbjct: 1320 KRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRT-K 1378
Query: 308 HSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLE------EKNTMYMQNTV-SLEEELRK 360
+ +D + + E E+ KK + L + + EK +Q V L +L +
Sbjct: 1379 YETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLER 1438
Query: 361 ANAARSQLE-----------TYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKE 409
++ A + L+ +K+++ E Q L K++ L E +++ + + +
Sbjct: 1439 SHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQ 1498
Query: 410 KDRLRTERDSLKETIEELRCVQAQEGQ--LTTQGLMPLGSQESSDSLAAEIVTPEIREKL 467
+ LR E +L+E I +L A+ G+ + L QE SD ++ E+ L
Sbjct: 1499 LETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSD---LQVALEEVEGSL 1555
Query: 468 IRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEEL 527
E+K+L++ E ++ ++S LD + K+E + Q Q E L
Sbjct: 1556 --EHEESKILRVQLE------LSQVKSELDRKVIEKDE------EIEQLKRNSQRAAEAL 1601
Query: 528 QKSLQDQGSKAEDSVLLKKKLEEHLE----KLHEANNELQKKRAIIEDLEPRFNNSSLKI 583
Q L + D++ LKKK+E L +L +N ++ + + + ++ + +S L +
Sbjct: 1602 QSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHL 1661
Query: 584 EELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRL 643
++ + +E++ +E R LE+ + + L+ + E + L +R +L
Sbjct: 1662 DDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELL--DASDRVQL 1719
Query: 644 FHSLEKEYEKTKSQREME 661
HS TK + E +
Sbjct: 1720 LHSQNTSLINTKKKLEAD 1737
Score = 69.3 bits (168), Expect = 1e-11
Identities = 95/428 (22%), Positives = 186/428 (43%), Gaps = 62/428 (14%)
Query: 302 EIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKA 361
+I L S++ ++ E +++ E+L + K LEEK +Q L+ +++
Sbjct: 839 KIKPLLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSE 898
Query: 362 NAARSQLE-----------TYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEK 410
E + +V EL RL EE + +L + + L++K SL+++
Sbjct: 899 TENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDI 958
Query: 411 DRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRL 470
D L EL + ++ + T+ + S+E + + E + +L
Sbjct: 959 DDL------------ELTLTKVEKEKHATENKVKNLSEEMT----------ALEENISKL 996
Query: 471 QHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKS 530
E K L QE Q LDD + ++++ N L+ +++ Q ++L+ S
Sbjct: 997 TKEKKSL---QEAH--------QQTLDDLQVEEDKV---NGLIKIN-AKLEQQTDDLEGS 1041
Query: 531 LQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIED--LEPRFNNSSL--KIEEL 586
L+ + D K+KLE L+ E+ +L+ + IE+ + F S L KI++
Sbjct: 1042 LEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDE 1101
Query: 587 QEALRKKEEEMKQMEERYKKYLE--KAKSVIRTLDPKQNQGAAPEIQALKNQLQERD--- 641
Q + ++++K+++ R ++ E +A+ +R KQ A E++ + +L+E
Sbjct: 1102 QVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGAT 1161
Query: 642 --RLFHSLEKEYEKTKSQREMEEKYIVSAWYNMGMTLHKKAAEDRLASTGSGQSFLARQR 699
++ + ++E E K +R++EE + TL KK A D +A G L R +
Sbjct: 1162 SAQIEMNKKREAEFQKMRRDLEEATLQHE--ATAATLRKKQA-DSVAELGEQIDNLQRVK 1218
Query: 700 QATSSRRS 707
Q +S
Sbjct: 1219 QKLEKEKS 1226
>gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]
Length = 1498
Score = 99.4 bits (246), Expect = 1e-20
Identities = 118/557 (21%), Positives = 254/557 (45%), Gaps = 74/557 (13%)
Query: 161 ESPVSAGNDAYVDLDR---QLKKTTEELNEALSA-KEEIAQRCHE---LDMQVAALQEEK 213
E+ + A +LDR +L++ TEE +E L +EE+A + + L + AAL+++
Sbjct: 779 EAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQM 838
Query: 214 SSL---LAENQVLMERLNQSDSIEDPN-SPAGRRHLQLQTQLEQLQEETFRLEAAKDDYR 269
+ + +V++E + + +D S +L ++L++L++E ++ K
Sbjct: 839 QKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAE 898
Query: 270 IRCEELEKEISELRQQNDELTTLADEAQSLKDEIDV----LRHSSDKVSKLEGQVESYKK 325
L +E++++RQ +L AQ +DE++ L+ +++ + E+ KK
Sbjct: 899 AELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKK 958
Query: 326 KLEDL-GDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSE 384
++E+L + R+ + ++K + S ++E++ + A Y+ V L RL E
Sbjct: 959 QIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKA------YENAVGILSRRLQE 1012
Query: 385 ESKKADKLDFEYKRLK-------------EKVDSLQKEKDRLRTERDSLKETIEELRCVQ 431
+ D E +L+ E++ +L+ E + + L++ ++E+ +
Sbjct: 1013 ALAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALT 1072
Query: 432 AQEGQLTTQGLMPLGSQ-ESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSDNEKIA 490
+QE + + + ++ L + + S +I E K + L+ E++ KL G N +
Sbjct: 1073 SQELEESREKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALR 1132
Query: 491 LLQSLLDDANLRKN----ELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSV-LLK 545
S+L+ A ++ +L + + V QR E Q++ L ++LQ K ++ V LK
Sbjct: 1133 EHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLK 1192
Query: 546 KKL----------EEHLE----KLHEANNELQKKRAII-------EDLEPRFNNSSLKIE 584
+++ H + +L E ELQ K ++ +DL+ R S +I
Sbjct: 1193 EQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIA 1252
Query: 585 ELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRLF 644
+ Q L + +++ ++++ + L K P NQ E++ LK ++ +++R
Sbjct: 1253 QFQAELAEARAQLQLLQKQLDEQLSK--------QPVGNQ----EMENLKWEVDQKEREI 1300
Query: 645 HSLEKEYEKTKSQREME 661
SL+++ + T+ Q E
Sbjct: 1301 QSLKQQLDLTEQQGRKE 1317
Score = 93.2 bits (230), Expect = 8e-19
Identities = 126/583 (21%), Positives = 262/583 (44%), Gaps = 90/583 (15%)
Query: 130 EQKQEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELNEAL 189
E+ Q + +E+ ++ V +T +Q ++ + A ++DL +QL T E L
Sbjct: 682 ERLQRMADSAASLEQQLEQVKLTLLQ----RDQQLEALQQEHLDLMKQLTLTQEALQSRE 737
Query: 190 SAKEEIAQRCHELDMQVAALQEEKSS------LLAENQVLMERLNQSDSIEDPNSPAGRR 243
+ + + EL ++ LQ E +S LL ++++E Q+ G R
Sbjct: 738 QSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSGKEELDRGAR 797
Query: 244 HLQLQTQLEQLQEETFRLEAAKDDYRIR---CEELEKEISELRQQNDELTTLADEAQSLK 300
L+ E +E + LE +++ I+ E L++E + L++Q ++ + Q L+
Sbjct: 798 RLE-----EGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKI-----KEQFLQ 847
Query: 301 DEIDVLRHSSDKVSK--LEGQVESYKKKLE-DLGDLRRQVKLLE-EKNTMYMQNTVSLEE 356
++ V + D SK L ++++ +K+L+ +L +LR+++ + EK T E
Sbjct: 848 QKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRT--------AEA 899
Query: 357 ELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRL---KEKVDSLQKEKDRL 413
EL + + +Q+ ++ + +L+ L K+ D+++ + L KE++ ++ + + L
Sbjct: 900 ELSRLHREVAQV---RQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEAL 956
Query: 414 RTERDSLKETIEELRCVQAQE----GQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIR 469
+ + + L++ + Q Q+ G T + ++ + A I++ ++E L
Sbjct: 957 KKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAA 1016
Query: 470 LQHENKML--KLNQEGSDNEKIAL----------LQSLLDDANLRKNELETENRLVNQRL 517
+ + L Q GS + +AL LQ++ L + EL+ L +Q L
Sbjct: 1017 KEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQEL 1076
Query: 518 LEVQSQVEELQKSLQDQG------SKAEDSVLLKKKLEEHLEK-------LHEANNELQK 564
E + +V EL+ LQ+ + E+S KKL LE L ++N L++
Sbjct: 1077 EESREKVLELEDELQESRGFRKKIKRLEES---NKKLALELEHEKGKLTGLGQSNAALRE 1133
Query: 565 KRAIIEDLEPRFNNSSLKIE-ELQEALRKKEEE---MKQMEERYKKYLEKAKSVIRTL-- 618
+I+E + +++ ++Q L++KEEE MK + + + LEK K + +L
Sbjct: 1134 HNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKE 1193
Query: 619 -----------DPKQNQGAAPEIQALKNQLQERDRLFHSLEKE 650
+ + + A+ E+ +K +LQ ++ L L+ E
Sbjct: 1194 QVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAE 1236
Score = 82.8 bits (203), Expect = 1e-15
Identities = 134/565 (23%), Positives = 239/565 (42%), Gaps = 65/565 (11%)
Query: 143 EESVQHVVMTAI--QELMSKESPVSAGNDAYVDLDRQLKKTTEELNEALSAKEEIAQRCH 200
E+ +Q VM ++ SK+ +S LD +LK+ +EL + K
Sbjct: 843 EQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAELS 902
Query: 201 ELDMQVAALQEEKSSLLAENQVLMERLNQSDSIEDPNSPAGRRHLQ-LQTQLEQLQEETF 259
L +VA +++ + L Q + ++ ++ HLQ LQ EQ+ T
Sbjct: 903 RLHREVAQVRQHMADLEGHLQSAQKERDEMET-----------HLQSLQFDKEQMVAVTE 951
Query: 260 RLEAAKDDYRIRCEELEKEISELRQQNDEL-TTLADEAQSLKDEIDVLRHSSDKVSKLEG 318
EA K +E K I+E +Q+ L + L + +K + ++ +S+
Sbjct: 952 ANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQ 1011
Query: 319 QVESYKKKLE-DLGDLRRQ-------------VKLLEEKNTMYMQNTVSLEEELRKANAA 364
+ + K+ + +LG LR Q ++ LE + + LE+EL++ A
Sbjct: 1012 EALAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIAL 1071
Query: 365 RSQ-LETYKRQVVELQNRLSEES---KKADKLDFEYKRL-------KEKVDSLQKEKDRL 413
SQ LE + +V+EL++ L E KK +L+ K+L K K+ L + L
Sbjct: 1072 TSQELEESREKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAAL 1131
Query: 414 RTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTP------EIREKL 467
R E +S+ ET R +A QL Q L +E D +V + +EK+
Sbjct: 1132 R-EHNSILETALAKR--EADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKV 1188
Query: 468 IRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQS-QVEE 526
L+ + K+ E N + SL + + K EL+ + LV + E Q+ E
Sbjct: 1189 NSLKEQVAAAKV--EAGHNRRHFKAASL--ELSEVKKELQAKEHLVQKLQAEADDLQIRE 1244
Query: 527 ---LQKSLQDQGSKAEDSV---LLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSS 580
Q+ Q Q AE LL+K+L+E L K N E++ + ++ E +
Sbjct: 1245 GKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLK 1304
Query: 581 LKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQ---- 636
+++ ++ RK+ E ++Q+ + K LE A+ + ++ K ++ LKN
Sbjct: 1305 QQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDL-SMTQKDKFMLQAKVSELKNNMKTL 1363
Query: 637 LQERDRLFHSLEKEYEKTKSQREME 661
LQ+ +L L + KT+ + + E
Sbjct: 1364 LQQNQQLKLDLRRGAAKTRKEPKGE 1388
Score = 82.4 bits (202), Expect = 1e-15
Identities = 101/508 (19%), Positives = 218/508 (42%), Gaps = 56/508 (11%)
Query: 172 VDLDRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSD 231
V L+ +T EE+ + L K + + L ++ + +EK+ L A+ L +L
Sbjct: 394 VSLESSAAETQEEMLQVLKEKMRLEGQLEALSLEASQALKEKAELQAQLAALSTKLQA-- 451
Query: 232 SIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTT 291
+E +S + +R L ++++ L++ + LE A D + LE + + L N++L
Sbjct: 452 QVECSHS-SQQRQDSLSSEVDTLKQSCWDLERAMTDLQ---NMLEAKNASLASSNNDLQV 507
Query: 292 LADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNT 351
++ Q L ++K+E S K + DLR+Q+ L+ +
Sbjct: 508 AEEQYQRL-------------MAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLER 554
Query: 352 VSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKE---------- 401
+L +L+ + A S L++ RQ + Q L++E++ + + + ++ +
Sbjct: 555 TTLTSKLKASQAEISSLQSV-RQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHL 613
Query: 402 KVDSLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTP 461
K++++ + T+ S+KE +Q E + Q + QE A +V
Sbjct: 614 KLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQE-----AKTMVEE 668
Query: 462 EIREKLIRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQ 521
+++ +L + E + L+ + + A L+ L+ L + + + + Q L++
Sbjct: 669 DLQRRLEEFEGERERLQRMADSA-----ASLEQQLEQVKLTLLQRDQQLEALQQEHLDLM 723
Query: 522 SQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSL 581
Q+ Q++LQ + + L+ H ++L ELQ + A ED N +
Sbjct: 724 KQLTLTQEALQSREQSLD-------ALQTHYDELQARLGELQGEAASREDTICLLQNEKI 776
Query: 582 KIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERD 641
+E +A + +EE+ + R ++ E+ + L E+ Q++
Sbjct: 777 ILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKL--------REELAIKSGQVEHLQ 828
Query: 642 RLFHSLEKEYEKTKSQREMEEKYIVSAW 669
+ +L+K+ +K K Q +++K +V A+
Sbjct: 829 QETAALKKQMQKIKEQ-FLQQKVMVEAY 855
Score = 74.3 bits (181), Expect = 4e-13
Identities = 141/650 (21%), Positives = 280/650 (43%), Gaps = 102/650 (15%)
Query: 113 AELGRMLQLILGCAVNCEQKQEYIQA-IMMMEESVQHV--VMTAIQELMSKE--SPVSAG 167
A L LQ + C+ + +Q+Q+ + + + +++S + MT +Q ++ + S S+
Sbjct: 443 AALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWDLERAMTDLQNMLEAKNASLASSN 502
Query: 168 NDAYVDLDR--QLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLME 225
ND V ++ +L E++ ++ +K+ H+L Q+ ALQ + + E L
Sbjct: 503 NDLQVAEEQYQRLMAKVEDMQRSMLSKDNTV---HDLRQQMTALQSQLQQVQLERTTLTS 559
Query: 226 RLNQSDSIEDPNSPAGRRHLQLQTQLEQ-----LQEETFRLEAAKDDYRIRCEELEKEIS 280
+L S + E + + R+ Q Q L Q LQ E ++ + E L+ E
Sbjct: 560 KLKASQA-EISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENV 618
Query: 281 ELRQQNDELT--------TLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGD 332
L QQ E +A + Q + E D+L + + Q++ K +E+ D
Sbjct: 619 SLSQQLTETQHRSMKEKGRIAAQLQGI--EADMLDQEAAFM-----QIQEAKTMVEE--D 669
Query: 333 LRRQVKLLE---EKNTMYMQNTVSLEEELRKANAA----RSQLETYKRQVVELQNRLSEE 385
L+R+++ E E+ + SLE++L + QLE +++ ++L +L+
Sbjct: 670 LQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLT 729
Query: 386 SKKADKLDFEYKRLKEKVDSLQKEKDRLRTERDSLKETI---EELRCVQAQEGQLTTQGL 442
+ + L+ D LQ L+ E S ++TI + + + Q G
Sbjct: 730 QEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSGK 789
Query: 443 MPL---------GSQESSDSLAAEIVTPEIREKLIRLQH-ENKMLKLNQEGSDNEKIALL 492
L G++E+S++L E + E+ K +++H + + L ++ ++ L
Sbjct: 790 EELDRGARRLEEGTEETSETL--EKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQ 847
Query: 493 QSLLDDANLR----KNELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKL 548
Q ++ +A R K++L +E + +RL S+++EL++ L + K+
Sbjct: 848 QKVMVEAYRRDATSKDQLISELKATRKRL---DSELKELRQELMQVHGE-------KRTA 897
Query: 549 EEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQM------EE 602
E L +LH E+ + R + DLE ++ + +E++ L+ + + +QM E
Sbjct: 898 EAELSRLH---REVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANE 954
Query: 603 RYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQREMEE 662
KK +E+ + R +A+ Q Q+ RL L T +Q+EM+
Sbjct: 955 ALKKQIEELQQEAR--------------KAITEQKQKMRRLGSDL------TSAQKEMKT 994
Query: 663 KYIVSAWYNMGMTLHKKAAEDRLASTGSGQSFLARQR-QATSSRRSYPGH 711
K+ Y + + + ++ LA+ + + L + R Q SS S H
Sbjct: 995 KHKA---YENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALH 1041
Score = 71.6 bits (174), Expect = 2e-12
Identities = 130/671 (19%), Positives = 273/671 (40%), Gaps = 121/671 (18%)
Query: 132 KQEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELNEALSA 191
K E +Q M+ +++ H + + L S+ V L +LK + E++ S
Sbjct: 518 KVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTT---LTSKLKASQAEISSLQSV 574
Query: 192 KEEIAQRCHELDMQVAALQEEKSSLLAE---------------NQVLMERLNQSDSIEDP 236
++ Q Q+A QE + L E + +E ++ S + +
Sbjct: 575 RQWYQQ-------QLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTET 627
Query: 237 NSPAGRRHLQLQTQLEQLQEETFRLEAA----KDDYRIRCEELEKEISELRQQNDELTTL 292
+ + ++ QL+ ++ + EAA ++ + E+L++ + E + + L +
Sbjct: 628 QHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQRM 687
Query: 293 ADEAQSL----------------------KDEIDVLRHSSDKVSKLEGQVES-------Y 323
AD A SL ++ +D+++ + L+ + +S Y
Sbjct: 688 ADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHY 747
Query: 324 KKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLS 383
+ LG+L+ + E+ + + LE L+ A + + +L+ R+ L+
Sbjct: 748 DELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSGKEELDRGARR---LEEGTE 804
Query: 384 EESKKADKLDFEYKRLKEKVDSLQKEKDRLRTERDSLKET-IEELRCVQAQEGQLTTQGL 442
E S+ +KL E +V+ LQ+E L+ + +KE +++ V+A T++
Sbjct: 805 ETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQ 864
Query: 443 MPLGSQESSDSLAAEIVTPEIREKLIRLQHENK-----MLKLNQEGSD-NEKIALLQSLL 496
+ + + L +E+ E+R++L+++ E + + +L++E + + +A L+ L
Sbjct: 865 LISELKATRKRLDSEL--KELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHL 922
Query: 497 DDANLRKNELETE-----------------NRLVNQRLLEVQ------------------ 521
A ++E+ET N + +++ E+Q
Sbjct: 923 QSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQKMRRLG 982
Query: 522 SQVEELQKSLQDQGSKAEDSV-LLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSS 580
S + QK ++ + E++V +L ++L+E L A+ EL + RA + ++SS
Sbjct: 983 SDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRA-----QGGSSDSS 1037
Query: 581 LKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQER 640
L + E +AL E Q K LEK + L ++ + + ++ L+++LQE
Sbjct: 1038 LALHERIQAL----EAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQE- 1092
Query: 641 DRLFHSLEKEYEKTKSQREMEEKYIVSAWYNMG-----MTLHKKAAEDRLASTGSGQSFL 695
R F K E++ + +E ++ +G + H E LA + L
Sbjct: 1093 SRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQL 1152
Query: 696 ARQRQATSSRR 706
Q QA R+
Sbjct: 1153 NLQVQAVLQRK 1163
Score = 44.7 bits (104), Expect = 3e-04
Identities = 79/381 (20%), Positives = 156/381 (40%), Gaps = 51/381 (13%)
Query: 69 WRLKISNLKKILKGI-LDYNHE---ILGQQINDFTLPDVNLIGEHSDAAELGRMLQLILG 124
+R KI L++ K + L+ HE + G ++ L + N I E + A ++QL L
Sbjct: 1096 FRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQLNL- 1154
Query: 125 CAVNCEQKQEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEE 184
+QA++ +E + +Q L + L+++ +K
Sbjct: 1155 ----------QVQAVLQRKEEEDRQMKHLVQALQAS-------------LEKEKEKVNSL 1191
Query: 185 LNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSDSIEDPNSPAGRRH 244
+ +AK E L E K L A+ ++ + ++D ++ +
Sbjct: 1192 KEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEI 1251
Query: 245 LQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEAQSLKDEID 304
Q Q +L + + + L+ D+ + +E+ L+ + D+ E QSLK ++D
Sbjct: 1252 AQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKER---EIQSLKQQLD 1308
Query: 305 VLRHSSDK-VSKLEGQVESYKKKLE----DLGDLRR-----QVKLLEEKNTM--YMQNTV 352
+ K + L+ +++ K +LE DL ++ Q K+ E KN M +Q
Sbjct: 1309 LTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQ 1368
Query: 353 SLEEELRKANAARSQLE-------TYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDS 405
L+ +LR+ AA+++ E + +++ + S + L KE + +
Sbjct: 1369 QLKLDLRRG-AAKTRKEPKGEASSSNPATPIKIPDCPVPASLLEELLRPPPAVSKEPLKN 1427
Query: 406 LQKEKDRLRTERDSLKETIEE 426
L +L+ E DSL+ +EE
Sbjct: 1428 LNSCLQQLKQEMDSLQRQMEE 1448
>gi|36031016 CTCL tumor antigen L14-2 [Homo sapiens]
Length = 898
Score = 98.2 bits (243), Expect = 2e-20
Identities = 126/531 (23%), Positives = 236/531 (44%), Gaps = 73/531 (13%)
Query: 130 EQKQEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELNEAL 189
E Q QA EE+ Q ++ + ++ + + L+++L+ +EL +
Sbjct: 289 EMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLRKEKET-LEKKLRDANKELEKNT 347
Query: 190 SAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSDSIE---DPNSPAGRRHLQ 246
+ ++++Q L + E + L+ E L E +N S I+ N
Sbjct: 348 NKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDIN-SHVIKVKWAQNKLKAEMDSH 406
Query: 247 LQTQLEQLQEETFRLEAAK---DDYRIRCEELEKEISELRQ-QNDEL-----TTLADEAQ 297
+T+ ++L+E T +L AK D R C+++ K E + +++EL T + +
Sbjct: 407 KETK-DKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNELDAKLRVTKGELEK 465
Query: 298 SLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEE 357
++++ D L K+ +LE ++K+ +++L LR +VK LE +E
Sbjct: 466 QMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRTLRTKVKCLE-------------DER 512
Query: 358 LRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRLRTER 417
LR + E RQ E+QN L ++ K AD+L + +R K+++++L++E + L +
Sbjct: 513 LRTEDELSKYKEIINRQKAEIQN-LLDKVKTADQLQEQLQRGKQEIENLKEEVESLNSLI 571
Query: 418 DSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKML 477
+ L++ IE R + E L T+ L +Q S+S + + ++ +LQ + + +
Sbjct: 572 NDLQKDIEGSR-KRESELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQCEQM 630
Query: 478 KLNQEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQ---SQVEELQKSLQDQ 534
K I L LL + LRK E++T + R EV+ +QVEEL+ L Q
Sbjct: 631 K-------QTNINLESRLLKEEELRKEEVQTLQAELACRQTEVKALSTQVEELKDELVTQ 683
Query: 535 GSKAEDSVL-LKKKLEEHLEKLHEANNELQKK-----------------RAIIEDLEPRF 576
K S+ L K+L++ KL + + K R+ ED P
Sbjct: 684 RRKHASSIKDLTKQLQQARRKLDQVESGSYDKEVSSMGSRSSSSGSLNARSSAEDRSPEN 743
Query: 577 NNSSL---------------KIEELQEALRKKEEEMKQMEERYKKYLEKAK 612
SS+ +I LQ+A +K E+++ ME+ K+ +E+ +
Sbjct: 744 TGSSVAVDNFPQVDKAMLIERIVRLQKAHARKNEKIEFMEDHIKQLVEEIR 794
Score = 75.9 bits (185), Expect = 1e-13
Identities = 110/515 (21%), Positives = 220/515 (42%), Gaps = 82/515 (15%)
Query: 155 QELMSKESPVSAGNDAYVDLDRQLKKTTEELNEALSA--KEEIAQRCHELDMQVAALQEE 212
++ +SK VSA D +++ +L T + + K E A E +Q LQ+E
Sbjct: 147 KKFISKIKSVSASEDLLEEIESELLSTEFAEHRVPNGMNKGEHALVLFEKCVQDKYLQQE 206
Query: 213 K--SSLLAEN----QVLMERLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKD 266
L+ EN ++ ++ ++ D++ R L+ +T+ E+ T +
Sbjct: 207 HIIKKLIKENKKHQELFVDICSEKDNL--------REELKKRTETEKQHMNTIK------ 252
Query: 267 DYRIRCEELEKEISELRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKK 326
R EEL KE+ R Q L + + K+ + L ++ ++E KK
Sbjct: 253 QLESRIEELNKEVKASRDQ------LIAQDVTAKNAVQQLH------KEMAQRMEQANKK 300
Query: 327 LEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEES 386
E+ +EK M M+ +E L R + ET ++++ + L + +
Sbjct: 301 CEEAR---------QEKEAMVMKYVRGEKESLD----LRKEKETLEKKLRDANKELEKNT 347
Query: 387 KKADKLDFEYKRLKEKVDSLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLG 446
K +L E RL + ++ + E RL E D LKE I ++ + Q + M
Sbjct: 348 NKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDINS-HVIKVKWAQNKLKAEMD-S 405
Query: 447 SQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNEL 506
+E+ D L E KL + + E ++ N + ++++ + ++ NEL
Sbjct: 406 HKETKDKLK------ETTTKLTQAKEEADQIRKNCQD-------MIKTYQESEEIKSNEL 452
Query: 507 ETENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKR 566
+ + R+ EL+K +Q++ + E K+LE+ E +EL+ R
Sbjct: 453 DAKLRVTKG----------ELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRTLR 502
Query: 567 AIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGA 626
++ LE + ++ + +E + +++ E++ + L+K K+ + + Q Q
Sbjct: 503 TKVKCLEDERLRTEDELSKYKEIINRQKAEIQNL-------LDKVKTADQLQE--QLQRG 553
Query: 627 APEIQALKNQLQERDRLFHSLEKEYEKTKSQREME 661
EI+ LK +++ + L + L+K+ E ++ +RE E
Sbjct: 554 KQEIENLKEEVESLNSLINDLQKDIEGSR-KRESE 587
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 97.4 bits (241), Expect = 4e-20
Identities = 132/586 (22%), Positives = 258/586 (44%), Gaps = 84/586 (14%)
Query: 155 QELMSKESPVSAGNDAY---------------------VDLDRQLKKTT------EELNE 187
+E+M+KE + + + L QL+ T EEL
Sbjct: 845 EEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRA 904
Query: 188 ALSA-KEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQ-SDSIEDPNSPAGRRHL 245
L+A K+E+ + CH+L+ +V +E L AE + + + + + + +E+ S R+ L
Sbjct: 905 RLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEES--ARQKL 962
Query: 246 QL-----QTQLEQLQEETFRLEAAKDDYRIRCEELEKEISE----LRQQNDELTTLADEA 296
QL + +L++L+EE LE + LE I+E L ++ ++ +LA
Sbjct: 963 QLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLK 1022
Query: 297 QSLKDEIDVLRHSSDKVSKLEGQVESYKKKLE-DLGDLRRQVKLLEEKNTMYMQNTVSLE 355
+ I L + K ++E ++KLE D DL Q+ L+ + E
Sbjct: 1023 NKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKE 1082
Query: 356 EELRKA-----------NAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVD 404
EEL+ A N A ++ + Q+ ELQ L E +K + + + L E+++
Sbjct: 1083 EELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELE 1142
Query: 405 SLQKE----------KDRLRTERDS----LKETIEE---LRCVQAQE-GQLTTQGLMPLG 446
+L+ E + LR++R+ LK+T+EE Q QE Q +Q + L
Sbjct: 1143 ALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELA 1202
Query: 447 SQ-ESSDSLAA--EIVTPEIREKLIRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRK 503
Q E + + A E + + L +E K+L L +G K +++ L + ++
Sbjct: 1203 EQLEQTKRVKANLEKAKQTLENERGELANEVKVL-LQGKGDSEHKRKKVEAQLQELQVKF 1261
Query: 504 NELETENRLVNQRLLEVQSQVEELQKSLQDQGSKA----EDSVLLKKKLEEHLEKLHEAN 559
NE E + ++ ++Q +++ + L SK+ +D L+ +L++ E L E N
Sbjct: 1262 NEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEEN 1321
Query: 560 NELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQMEER---YKKYLEKAKSVIR 616
+ ++ +E N+ ++EE +EA E+++ + + KK +E + +
Sbjct: 1322 RQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLE 1381
Query: 617 TLDPKQNQGAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQREMEE 662
T + + + +++ L + +E+ + LEK KT+ Q+E+++
Sbjct: 1382 TAEEVKRK-LQKDLEGLSQRHEEKVAAYDKLEK--TKTRLQQELDD 1424
Score = 94.0 bits (232), Expect = 4e-19
Identities = 120/600 (20%), Positives = 254/600 (42%), Gaps = 98/600 (16%)
Query: 109 HSDAAELGRMLQLILGCAVNCEQKQEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAG- 167
H+ A++ + ++ +GC E+ + +Q + + A +L ++ +
Sbjct: 1363 HAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQEL 1422
Query: 168 NDAYVDLDRQ------LKKTTEELNEALSAKEEI-AQRCHELDMQVAALQEEKSSLLAEN 220
+D VDLD Q L+K ++ ++ L+ ++ I A+ E D A +E+++ L+
Sbjct: 1423 DDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLA 1482
Query: 221 QVLMERLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEIS 280
+ L E + Q +E R + Q +T++E L ++KDD ELEK
Sbjct: 1483 RALEEAMEQKAELE-------RLNKQFRTEMEDLM-------SSKDDVGKSVHELEKSKR 1528
Query: 281 ELRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLL 340
L QQ +E+ T +E + D L+ + D +LE +++ K + E DL+ + +
Sbjct: 1529 ALEQQVEEMKTQLEELE------DELQATEDAKLRLEVNLQAMKAQFER--DLQGRDEQS 1580
Query: 341 EEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVV----ELQNRLSEESKKADKLDFEY 396
EEK ++ +E EL RS ++++ +L+ + +K D+ +
Sbjct: 1581 EEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQL 1640
Query: 397 KRLKEKVDSLQKEKDRLRTERDSL----KETIEELRCVQAQ----EGQLTTQGLMPLGSQ 448
++L+ ++ +E D R R+ + KE ++L+ ++A+ + +L +Q
Sbjct: 1641 RKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQ 1700
Query: 449 ESSDSLAAEIVTPEIREKLI---RLQHENKMLKLNQEGSDNE-KIALLQSLLDDANLR-- 502
+ D LA EI + L + + E ++ +L +E + + L+ L ANL+
Sbjct: 1701 QERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQID 1760
Query: 503 --------------KNE-----LETENRLVNQRLLEVQSQV------------------- 524
KNE LE +N+ + +L E++ V
Sbjct: 1761 QINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLE 1820
Query: 525 EELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIE 584
E+L +++ + + +KKL++ L ++ + ++ + + R ++E
Sbjct: 1821 EQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLE 1880
Query: 585 ELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRLF 644
E +E ++ ++++ + E A ++ R E+ +LKN+L+ D F
Sbjct: 1881 EAEEEAQRANASRRKLQRELEDATETADAMNR------------EVSSLKNKLRRGDLPF 1928
Score = 89.0 bits (219), Expect = 1e-17
Identities = 113/534 (21%), Positives = 231/534 (43%), Gaps = 56/534 (10%)
Query: 173 DLDRQLKKTTEELNEALSAKEEIA-------QRCHELDMQVAALQEE------------- 212
+L QL K EEL AL+ EE A ++ EL+ Q++ LQE+
Sbjct: 1073 ELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEK 1132
Query: 213 -KSSLLAENQVLMERLNQS-DSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRI 270
K L E + L L + DS +R ++ + L+EE EA + R
Sbjct: 1133 QKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQ 1192
Query: 271 RCEELEKEISELRQQNDELT--------TLADEAQSLKDEIDVLRH----SSDKVSKLEG 318
+ + +E++E +Q + TL +E L +E+ VL S K K+E
Sbjct: 1193 KHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEA 1252
Query: 319 QVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSL-EEELRKANAARSQLETYKRQVVE 377
Q++ + K + +R ++ K + + N L + K++ + Q+ +
Sbjct: 1253 QLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQD 1312
Query: 378 LQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRLRTERDSLKETIEELRCVQAQEGQL 437
Q L EE+++ L + K+++++ +S +++L E ++ +++ + AQ +
Sbjct: 1313 TQELLQEENRQKLSLSTKLKQVEDEKNSF---REQLEEEEEAKHNLEKQIATLHAQVADM 1369
Query: 438 TTQGLMPLGSQESSDSLAAEI------VTPEIREKLIRLQHENKMLKLNQEGSDNEKIAL 491
+ +G E+++ + ++ ++ EK+ K Q+ D+ + L
Sbjct: 1370 KKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDL 1429
Query: 492 LQSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEH 551
NL K + + + L ++ + + EE ++ + K ++ L + LEE
Sbjct: 1430 DHQRQSACNLEKKQKKFDQLLAEEKTISAK-YAEERDRAEAEAREKETKALSLARALEEA 1488
Query: 552 LEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLEKA 611
+E+ E ++ R +EDL ++ + EL+++ R E+++++M+ + ++ ++
Sbjct: 1489 MEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDEL 1548
Query: 612 KSVIRTLDPKQNQGAAPEIQALKNQ----LQERDRLFHSLEKEYEKTKSQREME 661
++ T D K +QA+K Q LQ RD S EK+ + + REME
Sbjct: 1549 QA---TEDAKLR--LEVNLQAMKAQFERDLQGRDE--QSEEKKKQLVRQVREME 1595
Score = 67.8 bits (164), Expect = 3e-11
Identities = 81/403 (20%), Positives = 184/403 (45%), Gaps = 53/403 (13%)
Query: 299 LKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRR----QVKLLEEKNTMYMQNTVSL 354
+K + V R + ++K E V+ +K+L L Q +L+ EK + +Q +
Sbjct: 834 VKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEK--LQLQEQLQA 891
Query: 355 EEEL-RKANAARSQLETYKRQVVE----LQNRLSEESKKADKLDFEYKRLKEKVDSLQKE 409
E EL +A R++L K+++ E L+ R+ EE ++ L E K++++ + L+++
Sbjct: 892 ETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQ 951
Query: 410 KDRLRTERDSLK----ETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVT----- 460
+ + R L+ T +L+ ++ ++ L Q ++ + AE T
Sbjct: 952 LEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEE 1011
Query: 461 PEIREKLIRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEV 520
E + L +L+++++ + + E E++ + + + +LE ++ ++ ++ E+
Sbjct: 1012 EEKSKSLAKLKNKHEAMITDLE----ERLRREEKQRQELEKTRRKLEGDSTDLSDQIAEL 1067
Query: 521 QSQ-----------VEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAII 569
Q+Q EELQ +L +A + KK+ E ++ E +L+ +RA
Sbjct: 1068 QAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASR 1127
Query: 570 EDLEPRFNNSSLKIEEL--------------QEALRKKEEEMKQMEERYKKYLEKAKSVI 615
E + + ++E L QE K+E+E+ +++ ++ + ++ I
Sbjct: 1128 NKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQI 1187
Query: 616 RTLDPKQNQGAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQR 658
+ + K +Q ++ L QL++ R+ +LEK + +++R
Sbjct: 1188 QEMRQKHSQA----VEELAEQLEQTKRVKANLEKAKQTLENER 1226
Score = 57.8 bits (138), Expect = 3e-08
Identities = 72/340 (21%), Positives = 142/340 (41%), Gaps = 52/340 (15%)
Query: 408 KEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKL 467
K K L+ R + +E V+ +E QL + + S +A ++ E +
Sbjct: 833 KVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAE 892
Query: 468 IRLQHENKMLK--LNQEGSDNEKIAL-LQSLLDDANLRKNELETENRLVNQRLLEVQSQV 524
L E + L+ L + + E+I L++ +++ R L+ E + + Q + E++ Q+
Sbjct: 893 TELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQL 952
Query: 525 EELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRF-------- 576
EE + + Q + + KKLEE L + N +L K++ ++ED F
Sbjct: 953 EEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEE 1012
Query: 577 ----------NNSSLKIEELQEALRKKEEEMKQMEERYKK-------------------- 606
N I +L+E LR++E++ +++E+ +K
Sbjct: 1013 EKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIA 1072
Query: 607 ----YLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQREMEE 662
L K + ++ + + AA + ALK +++E + L+++ E ++ R E
Sbjct: 1073 ELKMQLAKKEEELQAALARVEEEAAQKNMALK-KIRELESQISELQEDLESERASRNKAE 1131
Query: 663 KYIVSAWYNMGMTLH--KKAAEDRLASTGSGQSFLARQRQ 700
K ++G L K ED L ST + Q +++ Q
Sbjct: 1132 K----QKRDLGEELEALKTELEDTLDSTAAQQELRSKREQ 1167
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 97.4 bits (241), Expect = 4e-20
Identities = 108/526 (20%), Positives = 243/526 (46%), Gaps = 43/526 (8%)
Query: 154 IQELMSKESPVSAGNDAYVDLDRQLKKTTEELNEAL----SAKEEIAQRCHELDMQVAAL 209
I+EL + +S + +LKK EL E L S K EI EL ++
Sbjct: 199 IEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKL--- 255
Query: 210 QEEKSSLLAE---NQVLMERLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKD 266
E LL + N + E Q + + + ++ ++ Q E+L+E+ ++ ++
Sbjct: 256 -ERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEE 314
Query: 267 DYRIRCEELEKEISELRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKK 326
+ + L ++ ELR+Q EL E + L+++ + ++ +K+ + E ++ ++K
Sbjct: 315 KMWRQEKRLREQEKELREQEKELR----EQKELREQEEQMQEQEEKMWEQEEKMREQEEK 370
Query: 327 L----EDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVEL--QN 380
+ E L + +Q++ E+K + +E LR+ + E QV ++ +
Sbjct: 371 MWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEK 430
Query: 381 RLSEESKKA----DKLDFEYKRLKEKVDSLQKEKDRLRTERDSLKETIEELRCVQAQEGQ 436
++ E+ KK +K+ E +R++E+ +++E++ +R + + +++ E + + +E Q
Sbjct: 431 KMQEQEKKTRDQEEKMQ-EEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQ 489
Query: 437 LTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSDNEKIALLQSLL 496
Q +P E + L + E EK+ + + ++ +E EK Q +
Sbjct: 490 ---QQRLP----EQKEKLWEQEKMQEQEEKI---WEQEEKIRDQEEMWGQEKKMWRQEKM 539
Query: 497 DDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQGSKA---EDSVLLKKKLEEHLE 553
+ + E E + R Q++ + Q E ++K Q+Q K E+ + ++++ E +
Sbjct: 540 REQEDQMWEQEEKMRDQEQKMWD---QEERMEKKTQEQEKKTWDQEEKMREEERMREREK 596
Query: 554 KLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLEKAKS 613
K+ E ++++ +++ E + K+ E +E ++++EE+M + EE+ + EK
Sbjct: 597 KMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWE 656
Query: 614 VIRTLDPKQNQGAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQRE 659
R + K+ ++Q + ++QE++ EK +KT+ Q +
Sbjct: 657 QQRLPEQKEKLWEHEKMQE-QEKMQEQEEKIWEQEKMEKKTQEQEK 701
Score = 86.3 bits (212), Expect = 9e-17
Identities = 112/601 (18%), Positives = 257/601 (42%), Gaps = 82/601 (13%)
Query: 130 EQKQEYIQAIMMMEESVQHVVMTAIQELMSKES------PVSAGNDAYVDLDRQLKKTTE 183
++K +Q + + ES + + ++EL K P N ++ RQ ++ E
Sbjct: 224 KKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELRE 283
Query: 184 ELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSDSIEDPNSPAGRR 243
+ + +E++ ++ L Q ++E++ + + + L E Q + + R
Sbjct: 284 QEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLRE---QEKELREQEKEL-RE 339
Query: 244 HLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEAQSLKDEI 303
+L+ Q EQ+QE+ ++ ++ R + E++ ++ L +Q ++ ++ Q ++D+
Sbjct: 340 QKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMR---EQEQKMRDQE 396
Query: 304 DVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLE-EKNTMYMQNTVSLEEELRKAN 362
+ + +++ + E ++ +K E + +R + K+ E EK T + + EE +R+
Sbjct: 397 ERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIRERE 456
Query: 363 AARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSL---------------Q 407
+ E R+ E + E + ++ +++ +RL E+ + L Q
Sbjct: 457 KKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQ 516
Query: 408 KEK-----------------DRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQES 450
+EK +++R + D + E E++R + + + QE
Sbjct: 517 EEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEK 576
Query: 451 SDSLAAEIVTPE--IREKLIRLQHENKMLKLNQEG--SDNEKIALLQSLLDDANLRKNEL 506
E + E +RE+ +++ E +M++ +E EK+ + + + + E
Sbjct: 577 KTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQ 636
Query: 507 ET-------------ENRLVNQRLLEVQSQVEELQK-----SLQDQGSKAEDSVLLKKKL 548
E E QRL E + ++ E +K +Q+Q K + ++KK
Sbjct: 637 EEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKT 696
Query: 549 EEH------LEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQMEE 602
+E EK+ E + ++++ + E+ E K++E +E ++++EEEM + EE
Sbjct: 697 QEQEKKTWDQEKMREEESMREREKKMREE-EEMMREQEEKMQEQEEKMQEQEEEMWEQEE 755
Query: 603 RYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQREMEE 662
+ + EK R + K+ ++QE+++++ EK ++ + R EE
Sbjct: 756 KMWEQEEKMWEQQRLPEQKEKLWE-------HEKMQEQEKIWEQEEKMRDQEEKMRGQEE 808
Query: 663 K 663
K
Sbjct: 809 K 809
Score = 82.8 bits (203), Expect = 1e-15
Identities = 108/557 (19%), Positives = 250/557 (44%), Gaps = 58/557 (10%)
Query: 130 EQKQEYIQAIMMMEESV---QHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELN 186
EQ QE + + EE + + + + L +E + D + ++ + E L
Sbjct: 348 EQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLR 407
Query: 187 EALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVL--MERLNQSDSIEDPNSPAGRRH 244
E KEE + ++ QV ++EEK E + E++ + + I + R
Sbjct: 408 E----KEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIRE-------RE 456
Query: 245 LQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEAQSLKDEID 304
+++ + E ++E+ +++ +++ + EE E + L +Q ++L E + ++++ +
Sbjct: 457 KKMREEEETMREQEEKMQKQEENMWEQ-EEKEWQQQRLPEQKEKLW----EQEKMQEQEE 511
Query: 305 VLRHSSDKVSKLEGQVESYKK--KLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKAN 362
+ +K+ E KK + E + + Q+ EEK Q EE + K
Sbjct: 512 KIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKT 571
Query: 363 AARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRLRTERDSLKE 422
+ + + + + + R+ E KK + E + ++E+ + +Q+++++++ + + + E
Sbjct: 572 QEQEKKTWDQEEKMREEERMREREKKMRE---EEEMMREQEEKMQEQEEKMQEQEEKMWE 628
Query: 423 TIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLI---RLQHENKMLKL 479
E++ Q QE ++ Q E + + + PE +EKL ++Q + KM +
Sbjct: 629 QEEKM---QEQEEKMWEQEEK---MWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQ 682
Query: 480 NQEGSDNEKIALL-----QSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQ 534
++ + EK+ + D +R+ E E +++ E + + E ++ +Q+Q
Sbjct: 683 EEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMRERE---KKMREEEEMMREQEEKMQEQ 739
Query: 535 GSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSL----KIEELQEAL 590
K ++ ++++ E EK+ E ++ +++ + E E + + + KI E +E +
Sbjct: 740 EEKMQEQ---EEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKM 796
Query: 591 RKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRLFHSLEKE 650
R +EE+M+ EE+ + EK + + ++ + E + + ++++ EK
Sbjct: 797 RDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQE----EKMWGQEEKMWGQEEKM 852
Query: 651 YEKTKSQ----REMEEK 663
EK + Q RE EEK
Sbjct: 853 EEKMQGQEEKMREQEEK 869
Score = 80.9 bits (198), Expect = 4e-15
Identities = 104/470 (22%), Positives = 218/470 (46%), Gaps = 36/470 (7%)
Query: 214 SSLLAENQVLMERLNQS----DSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYR 269
S + E++ L RL+ S ++ S RH + +E+L +E L
Sbjct: 158 SLIPGESKDLAGRLHHSWHFAGELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNT 217
Query: 270 IRCEELEKEISELRQQ----NDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKK 325
I EEL+K+ +EL+++ E + + + LK +++ + +V Q E +++
Sbjct: 218 ITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQ 277
Query: 326 KLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKANA-ARSQLETYKRQVVELQNRLSE 384
+ E+L + ++++ EEK M+ Q EE LR+ R Q E RQ L+ + +
Sbjct: 278 E-EELREQEKKIRKQEEK--MWRQ-----EERLREQEGKMREQEEKMWRQEKRLREQ-EK 328
Query: 385 ESKKADKLDFEYKRLKEKVDSLQKEKDRLRTERDSLKETIEEL----RCVQAQEGQLTTQ 440
E ++ +K E K L+E+ + +Q++++++ + + ++E E++ + QE Q+ Q
Sbjct: 329 ELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQ 388
Query: 441 GLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSDNEKIALLQSLLDDAN 500
+ QE E +REK R++ + KM + ++ + +K+ + D
Sbjct: 389 E-QKMRDQEERMWEQDE----RLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQE 443
Query: 501 LRKNELETENRLVNQRLLEVQSQVEELQKSLQDQGS---KAEDSVLLKKKLEEHLEKLHE 557
+ E E R +++ E + + E ++ +Q Q + E+ +++L E EKL E
Sbjct: 444 EKMQE-EERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWE 502
Query: 558 ANNELQKKRAIIEDLEPRFNNSSLKIEE----LQEALRKKEEEMKQMEERYKKYLEKAKS 613
+++ I E E + + +E QE +R++E++M + EE+ + +K
Sbjct: 503 QEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWD 562
Query: 614 VIRTLDPKQNQGAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQREMEEK 663
++ K+ Q + + +++E +R+ +K E+ + RE EEK
Sbjct: 563 QEERME-KKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEK 611
Score = 48.9 bits (115), Expect = 2e-05
Identities = 62/306 (20%), Positives = 131/306 (42%), Gaps = 53/306 (17%)
Query: 398 RLKEKVDSLQKEKDRLRTERDSLKETIEELRCVQA----------------QEGQLTTQG 441
+LKE+ + + ++ LR E ++ TI L C + ++G L T
Sbjct: 78 QLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFEDGNLGTPS 137
Query: 442 LM-----------PLGSQES------SDSLAAEI-----VTPEIREKLIRLQHENKMLKL 479
PLG + S LA + E++ L + +K
Sbjct: 138 SFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGELQRALSAVSTRHKKADR 197
Query: 480 NQEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAE 539
E E+ AL L + + EL+ +N + ++L +S+ E+Q ++++ K E
Sbjct: 198 YIEELTKERDALSLELYRN-TITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLE 256
Query: 540 DSVLLKKKLEEHL--EKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEEM 597
+ L +++ + E++ EL+++ I E + ++ E + +R++EE+M
Sbjct: 257 RAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKM 316
Query: 598 KQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQ 657
+ E+R ++ ++ + + L ++ E++ + Q+QE++ EK +E+ +
Sbjct: 317 WRQEKRLREQEKELREQEKELREQK------ELREQEEQMQEQE------EKMWEQEEKM 364
Query: 658 REMEEK 663
RE EEK
Sbjct: 365 REQEEK 370
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 97.4 bits (241), Expect = 4e-20
Identities = 122/534 (22%), Positives = 233/534 (43%), Gaps = 68/534 (12%)
Query: 176 RQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSDSIED 235
RQ K EE+ E L AK E A+R E Q +A Q + + A+ ++ E + +++
Sbjct: 2002 RQRKAALEEV-ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2060
Query: 236 PNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADE 295
+ Q Q+ L+QL+ E A ++ + E+E ++ R+Q +E L
Sbjct: 2061 KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQS 2120
Query: 296 AQSLKDEIDVLRHSSDKVSK----------------------LEGQVESYKKKLEDLGDL 333
A+ + +++K+ K + ++E +KK E L
Sbjct: 2121 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT--L 2178
Query: 334 RRQVKLLEEKNTMYMQNTVS------LEEELRKANAARSQLETYKRQVVE----LQNRLS 383
R++ ++ +E T+ +Q + L+EEL++ A ++ + QV E ++ ++
Sbjct: 2179 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2238
Query: 384 EESKKADKLDFEYKRLKEKVDSLQKEKDR----LRTERDSLKETIEELR--CVQAQEG-- 435
E SK +++ E + L + ++KD L+ E + +K+ EE V AQE
Sbjct: 2239 ELSKLKARIEAENRAL------ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2292
Query: 436 --QLTTQGLMP---LGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSDNEKIA 490
QL + L L + + + A ++ + LQ + ++ + +K
Sbjct: 2293 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2352
Query: 491 LLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQD----QGSKAEDSVLLKK 546
+ Q L ++ + LE E QR LE+ ++ E L+ + + Q ED+ +K
Sbjct: 2353 MAQQLAEETQGFQRTLEAER----QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2408
Query: 547 KLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKK 606
+ EE EKLH Q+K +++ LE + S E L+EA+ + E E +++++ K
Sbjct: 2409 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL 2468
Query: 607 YLEKAKSVIRTLDPKQNQGAAPEIQALKNQ-LQERDRLFHSLEKEYEKTKSQRE 659
K++ + Q + E QAL+ L E+D L E+ E+ K++ E
Sbjct: 2469 LQLKSEE----MQTVQQEQLLQETQALQQSFLSEKDSLLQR-ERFIEQEKAKLE 2517
Score = 90.5 bits (223), Expect = 5e-18
Identities = 113/534 (21%), Positives = 233/534 (43%), Gaps = 57/534 (10%)
Query: 130 EQKQEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELNEAL 189
EQ Q QA E+ + A + ++++ + A ++++ K + L +
Sbjct: 2123 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2182
Query: 190 SAKEEIAQ---RCHELDMQVAALQEEKSSLLAENQVLMERLNQSDSIEDPNSPAGRRHLQ 246
++E+ + E D Q L EE L AE E Q +E+
Sbjct: 2183 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAE---ATEAARQRSQVEE-------ELFS 2232
Query: 247 LQTQLEQLQEETFRLEAAKDDYRIRCEE-----LEKEISELRQQNDE---LTTLADEAQS 298
++ Q+E+L + R+EA +R ++ L++E +++Q +E L+ A EA
Sbjct: 2233 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2292
Query: 299 LK----DEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSL 354
L+ +++ R ++K+ K + Q +L+ +L +Q K L ++ +Q
Sbjct: 2293 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ----- 2347
Query: 355 EEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRLR 414
E++ + A + + ++R + + R E S +A++L + +++ R R
Sbjct: 2348 EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR 2407
Query: 415 TERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHEN 474
+ + + E + + QE Q L Q D+ E+ + +LQ E
Sbjct: 2408 KQAEEIGEKLHRTE-LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEA 2466
Query: 475 KMLKLNQEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQ 534
K+L+L E + + + Q L + L+++ L ++ L+ QR ++ + +L++ QD+
Sbjct: 2467 KLLQLKSE--EMQTVQQEQLLQETQALQQSFLSEKDSLL-QRERFIEQEKAKLEQLFQDE 2523
Query: 535 GSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKE 594
+KA+ + EE + + E Q+ A +E+ R + E +E +R+K+
Sbjct: 2524 VAKAQ------QLREEQQRQQQQMEQERQRLVASMEEARRRQH-------EAEEGVRRKQ 2570
Query: 595 EEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRLFHSLE 648
EE++Q+E++ ++ E L ++NQ ++Q L+ Q R L HS E
Sbjct: 2571 EELQQLEQQRRQQEE--------LLAEENQRLREQLQLLEE--QHRAALAHSEE 2614
Score = 86.7 bits (213), Expect = 7e-17
Identities = 122/567 (21%), Positives = 252/567 (44%), Gaps = 53/567 (9%)
Query: 133 QEYIQAIMMMEESVQHVVMTAIQELMS---KESPVSAGNDA----YVDLDRQLKKTTEEL 185
++YI AI E +Q V A E ++ K+ V +G+++ YVDL + T
Sbjct: 1273 KQYINAIKDYE--LQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLT 1330
Query: 186 NEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQ-SDSIEDPNSPAGRRH 244
++ + E +R E + + E+ LAE + +E+ Q +++ + A R
Sbjct: 1331 SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA 1390
Query: 245 LQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQND-ELTTLADEAQS----- 298
+LQ +++QEE R E A D + + +++E+ +LRQ ++ E+ A +A++
Sbjct: 1391 KELQ---QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1447
Query: 299 --LKDEIDVLRHSSDKVSK----LEGQVESYKKKLEDLGDLRRQV--------KLLEEKN 344
+++EI V+R + + EG++++ + + E+ +RQ + +++++
Sbjct: 1448 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1507
Query: 345 TMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKR-LKEKV 403
Q V L ++ A + + + + EL+ + E ++ + + E R ++ +
Sbjct: 1508 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL 1567
Query: 404 DSLQKEKD-RLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPE 462
++ Q+ + L+++R S E +L QE + L + + AE E
Sbjct: 1568 ETAQRSAEAELQSKRASFAEKTAQLE-RSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1626
Query: 463 IREKLIRLQ-HENKMLKLNQEGSDNEKIALLQSLLD-DANLRKNELETENRLVNQRLLEV 520
+L R Q N+ L+L + E++A +SL +A +K E E E R + +
Sbjct: 1627 AERELERWQLKANEALRLRLQA---EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1683
Query: 521 QSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIED----LEPRF 576
Q E ++ L+ Q AE + + E+ L +L + +++R ++E+ L+
Sbjct: 1684 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1743
Query: 577 NNSSLKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQ 636
++ K +EL+ L K EM+ + + E+++S K Q E +
Sbjct: 1744 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRST----SEKSKQRLEAEAGRFREL 1799
Query: 637 LQERDRLFHSLEKEYEKTKSQREMEEK 663
+E R L E+ K QR++ E+
Sbjct: 1800 AEEAAR----LRALAEEAKRQRQLAEE 1822
Score = 82.0 bits (201), Expect = 2e-15
Identities = 142/630 (22%), Positives = 273/630 (43%), Gaps = 75/630 (11%)
Query: 108 EHSDAAELGRMLQLILGCAVNCEQKQEYI-QAIMMMEESVQHVVMTAIQELMSKESPVSA 166
E A E R LQ + + E+ + + QA + VQ + TA + S E+ + +
Sbjct: 1524 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR---SAEAELQS 1580
Query: 167 GNDAYVDLDRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAE-----NQ 221
++ + QL+++ +E + A++ E A+R + + +EE L N+
Sbjct: 1581 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1640
Query: 222 VLMERLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISE 281
L RL Q++ + S A + + Q E+ + E R A++ +R EL ++ E
Sbjct: 1641 ALRLRL-QAEEVAQQKSLA---QAEAEKQKEEAEREARRRGKAEEQ-AVRQRELAEQ--E 1693
Query: 282 LRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLE 341
L +Q A + + + E+ LR +++ + +E E+L L+R+
Sbjct: 1694 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE------EELARLQREAAAAT 1747
Query: 342 EKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKE 401
+K LE EL K A L K + E SE+SK+ +L+ E R +E
Sbjct: 1748 QKRQ-------ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQ--RLEAEAGRFRE 1798
Query: 402 ------KVDSLQKEKDRLR--TERDSLKETIEELRCVQ------AQEGQLTTQGLMPLGS 447
++ +L +E R R E D+ ++ E R + + +L T+ + L
Sbjct: 1799 LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE 1858
Query: 448 QESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELE 507
+E+ + + E ++ RL+ + K + E E++A L+ D R+ L
Sbjct: 1859 KEAENERLRRLAEDEAFQRR-RLEEQAAQHKADIE----ERLAQLRKASDSELERQKGLV 1913
Query: 508 TEN----RLVNQRLLEVQSQVE-------ELQKSLQDQGSKAEDSVLLKKKLEEHLEKLH 556
+ R V + +L +++ E EL+ L S AED++ K++ E +
Sbjct: 1914 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1973
Query: 557 EANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIR 616
+ E +++R E+ + SL EE EA R+++ ++++ ER K +E+A R
Sbjct: 1974 QLAAEEERRRREAEERVQK----SLAAEE--EAARQRKAALEEV-ERLKAKVEEA----R 2022
Query: 617 TLDPKQNQGAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQREMEEKYIVSAWYNMGMTL 676
L + Q +A ++Q + Q+R + EK + Q+E E + + ++ L
Sbjct: 2023 RLRERAEQESARQLQLAQEAAQKR---LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2079
Query: 677 HKKAAEDRLASTGSGQSFLARQRQATSSRR 706
+A R A+ + ++ + +R+A SRR
Sbjct: 2080 RGEAEAARRAAEEAEEARVQAEREAAQSRR 2109
Score = 38.1 bits (87), Expect = 0.029
Identities = 83/424 (19%), Positives = 168/424 (39%), Gaps = 65/424 (15%)
Query: 297 QSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEE 356
Q ++ + L + L Q+ K L LRR V+L+ + + T+ EE
Sbjct: 863 QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFR-TLKPEE 921
Query: 357 ELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRLRTE 416
+ + ++ + + R + E+ A++ EY L + ++ E
Sbjct: 922 QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAER---EYGSCSHHYQQLLQSLEQGAQE 978
Query: 417 RDSLKETIEELRCVQAQEGQLTTQGL----MPLGSQESSDSLAAEIVTPEIREKLIRLQH 472
+ I EL+ ++ Q T+ + +PL + A E ++ + +
Sbjct: 979 ESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEP-----ARECAQRIAEQQKAQAEV 1033
Query: 473 ENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELE-TENRLVNQRLLEVQSQVEELQK-S 530
E + + ++ EK+ L A ++ELE T +L R L +E+L+ S
Sbjct: 1034 EGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSA-IYLEKLKTIS 1092
Query: 531 LQDQGSKAEDSVLL--KKKLEEH------LEKLHEANNELQKKRAIIEDLEPRFNNSSLK 582
L +G++ + VL +++L+E L +L L+K RA E +P F+ +
Sbjct: 1093 LVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDE 1152
Query: 583 I-------EELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQ------------- 622
+ E LQ+ +++ E+++ ER + LE+ ++V+ D +Q
Sbjct: 1153 LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY 1212
Query: 623 NQGAAP---------------------EIQALKNQLQERDRLFHSLEKEYEKTKSQREME 661
+ A P + QA++ QL++ L +E+ EK + +
Sbjct: 1213 RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1272
Query: 662 EKYI 665
++YI
Sbjct: 1273 KQYI 1276
Score = 30.8 bits (68), Expect = 4.6
Identities = 75/397 (18%), Positives = 155/397 (39%), Gaps = 49/397 (12%)
Query: 129 CEQKQEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELNEA 188
CE++ A++ + V + A ++ + V D + R L + L +
Sbjct: 408 CEEQLNQADALLQSD-----VRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDG 462
Query: 189 LSAK-EEIAQRCHELDMQVAALQEEKSSLLAEN---------QVLMERLNQSDSIEDPNS 238
+ E++ +R + L ++ A++ E + L QV ++ + + +ED
Sbjct: 463 RHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTL 522
Query: 239 PAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISE---LRQQNDELTTLADE 295
LQ L ++E R++ A ++ + +E ++ L Q +E +
Sbjct: 523 R------YLQDLLAWVEENQHRVDGA--EWGVDLPSVEAQLGSHRGLHQSIEEFRAKIER 574
Query: 296 AQSLKDEIDVLRHSS--DKVSKLEGQ----VESYKKKLEDLGDLRRQVKLLEEKNTMYMQ 349
A+S + ++ + D + +L+ Q + S K +L L L V K M++
Sbjct: 575 ARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAAT-KELMWLN 633
Query: 350 NTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKE 409
EEE+ + R+ T K++ R +L+ + K++KE LQ
Sbjct: 634 EKE--EEEVGFDWSDRNTNMTAKKESYSALMR---------ELELKEKKIKE----LQNA 678
Query: 410 KDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIR 469
DRL E + T+E + + Q + + ++ + + ++RE +
Sbjct: 679 GDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFS-DVREAEGQ 737
Query: 470 LQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNEL 506
LQ + L+ + + L+ LL DA K +L
Sbjct: 738 LQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQL 774
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 97.4 bits (241), Expect = 4e-20
Identities = 122/534 (22%), Positives = 233/534 (43%), Gaps = 68/534 (12%)
Query: 176 RQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSDSIED 235
RQ K EE+ E L AK E A+R E Q +A Q + + A+ ++ E + +++
Sbjct: 2006 RQRKAALEEV-ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2064
Query: 236 PNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADE 295
+ Q Q+ L+QL+ E A ++ + E+E ++ R+Q +E L
Sbjct: 2065 KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQS 2124
Query: 296 AQSLKDEIDVLRHSSDKVSK----------------------LEGQVESYKKKLEDLGDL 333
A+ + +++K+ K + ++E +KK E L
Sbjct: 2125 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT--L 2182
Query: 334 RRQVKLLEEKNTMYMQNTVS------LEEELRKANAARSQLETYKRQVVE----LQNRLS 383
R++ ++ +E T+ +Q + L+EEL++ A ++ + QV E ++ ++
Sbjct: 2183 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2242
Query: 384 EESKKADKLDFEYKRLKEKVDSLQKEKDR----LRTERDSLKETIEELR--CVQAQEG-- 435
E SK +++ E + L + ++KD L+ E + +K+ EE V AQE
Sbjct: 2243 ELSKLKARIEAENRAL------ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2296
Query: 436 --QLTTQGLMP---LGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSDNEKIA 490
QL + L L + + + A ++ + LQ + ++ + +K
Sbjct: 2297 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2356
Query: 491 LLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQD----QGSKAEDSVLLKK 546
+ Q L ++ + LE E QR LE+ ++ E L+ + + Q ED+ +K
Sbjct: 2357 MAQQLAEETQGFQRTLEAER----QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2412
Query: 547 KLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKK 606
+ EE EKLH Q+K +++ LE + S E L+EA+ + E E +++++ K
Sbjct: 2413 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL 2472
Query: 607 YLEKAKSVIRTLDPKQNQGAAPEIQALKNQ-LQERDRLFHSLEKEYEKTKSQRE 659
K++ + Q + E QAL+ L E+D L E+ E+ K++ E
Sbjct: 2473 LQLKSEE----MQTVQQEQLLQETQALQQSFLSEKDSLLQR-ERFIEQEKAKLE 2521
Score = 90.5 bits (223), Expect = 5e-18
Identities = 113/534 (21%), Positives = 233/534 (43%), Gaps = 57/534 (10%)
Query: 130 EQKQEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELNEAL 189
EQ Q QA E+ + A + ++++ + A ++++ K + L +
Sbjct: 2127 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2186
Query: 190 SAKEEIAQ---RCHELDMQVAALQEEKSSLLAENQVLMERLNQSDSIEDPNSPAGRRHLQ 246
++E+ + E D Q L EE L AE E Q +E+
Sbjct: 2187 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAE---ATEAARQRSQVEE-------ELFS 2236
Query: 247 LQTQLEQLQEETFRLEAAKDDYRIRCEE-----LEKEISELRQQNDE---LTTLADEAQS 298
++ Q+E+L + R+EA +R ++ L++E +++Q +E L+ A EA
Sbjct: 2237 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2296
Query: 299 LK----DEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSL 354
L+ +++ R ++K+ K + Q +L+ +L +Q K L ++ +Q
Sbjct: 2297 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ----- 2351
Query: 355 EEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRLR 414
E++ + A + + ++R + + R E S +A++L + +++ R R
Sbjct: 2352 EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR 2411
Query: 415 TERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHEN 474
+ + + E + + QE Q L Q D+ E+ + +LQ E
Sbjct: 2412 KQAEEIGEKLHRTE-LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEA 2470
Query: 475 KMLKLNQEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQ 534
K+L+L E + + + Q L + L+++ L ++ L+ QR ++ + +L++ QD+
Sbjct: 2471 KLLQLKSE--EMQTVQQEQLLQETQALQQSFLSEKDSLL-QRERFIEQEKAKLEQLFQDE 2527
Query: 535 GSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKE 594
+KA+ + EE + + E Q+ A +E+ R + E +E +R+K+
Sbjct: 2528 VAKAQ------QLREEQQRQQQQMEQERQRLVASMEEARRRQH-------EAEEGVRRKQ 2574
Query: 595 EEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRLFHSLE 648
EE++Q+E++ ++ E L ++NQ ++Q L+ Q R L HS E
Sbjct: 2575 EELQQLEQQRRQQEE--------LLAEENQRLREQLQLLEE--QHRAALAHSEE 2618
Score = 86.7 bits (213), Expect = 7e-17
Identities = 122/567 (21%), Positives = 252/567 (44%), Gaps = 53/567 (9%)
Query: 133 QEYIQAIMMMEESVQHVVMTAIQELMS---KESPVSAGNDA----YVDLDRQLKKTTEEL 185
++YI AI E +Q V A E ++ K+ V +G+++ YVDL + T
Sbjct: 1277 KQYINAIKDYE--LQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLT 1334
Query: 186 NEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQ-SDSIEDPNSPAGRRH 244
++ + E +R E + + E+ LAE + +E+ Q +++ + A R
Sbjct: 1335 SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA 1394
Query: 245 LQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQND-ELTTLADEAQS----- 298
+LQ +++QEE R E A D + + +++E+ +LRQ ++ E+ A +A++
Sbjct: 1395 KELQ---QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1451
Query: 299 --LKDEIDVLRHSSDKVSK----LEGQVESYKKKLEDLGDLRRQV--------KLLEEKN 344
+++EI V+R + + EG++++ + + E+ +RQ + +++++
Sbjct: 1452 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1511
Query: 345 TMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKR-LKEKV 403
Q V L ++ A + + + + EL+ + E ++ + + E R ++ +
Sbjct: 1512 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL 1571
Query: 404 DSLQKEKD-RLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPE 462
++ Q+ + L+++R S E +L QE + L + + AE E
Sbjct: 1572 ETAQRSAEAELQSKRASFAEKTAQLE-RSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1630
Query: 463 IREKLIRLQ-HENKMLKLNQEGSDNEKIALLQSLLD-DANLRKNELETENRLVNQRLLEV 520
+L R Q N+ L+L + E++A +SL +A +K E E E R + +
Sbjct: 1631 AERELERWQLKANEALRLRLQA---EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1687
Query: 521 QSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIED----LEPRF 576
Q E ++ L+ Q AE + + E+ L +L + +++R ++E+ L+
Sbjct: 1688 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1747
Query: 577 NNSSLKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQ 636
++ K +EL+ L K EM+ + + E+++S K Q E +
Sbjct: 1748 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRST----SEKSKQRLEAEAGRFREL 1803
Query: 637 LQERDRLFHSLEKEYEKTKSQREMEEK 663
+E R L E+ K QR++ E+
Sbjct: 1804 AEEAAR----LRALAEEAKRQRQLAEE 1826
Score = 82.0 bits (201), Expect = 2e-15
Identities = 142/630 (22%), Positives = 273/630 (43%), Gaps = 75/630 (11%)
Query: 108 EHSDAAELGRMLQLILGCAVNCEQKQEYI-QAIMMMEESVQHVVMTAIQELMSKESPVSA 166
E A E R LQ + + E+ + + QA + VQ + TA + S E+ + +
Sbjct: 1528 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR---SAEAELQS 1584
Query: 167 GNDAYVDLDRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAE-----NQ 221
++ + QL+++ +E + A++ E A+R + + +EE L N+
Sbjct: 1585 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1644
Query: 222 VLMERLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISE 281
L RL Q++ + S A + + Q E+ + E R A++ +R EL ++ E
Sbjct: 1645 ALRLRL-QAEEVAQQKSLA---QAEAEKQKEEAEREARRRGKAEEQ-AVRQRELAEQ--E 1697
Query: 282 LRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLE 341
L +Q A + + + E+ LR +++ + +E E+L L+R+
Sbjct: 1698 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE------EELARLQREAAAAT 1751
Query: 342 EKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKE 401
+K LE EL K A L K + E SE+SK+ +L+ E R +E
Sbjct: 1752 QKRQ-------ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQ--RLEAEAGRFRE 1802
Query: 402 ------KVDSLQKEKDRLR--TERDSLKETIEELRCVQ------AQEGQLTTQGLMPLGS 447
++ +L +E R R E D+ ++ E R + + +L T+ + L
Sbjct: 1803 LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE 1862
Query: 448 QESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELE 507
+E+ + + E ++ RL+ + K + E E++A L+ D R+ L
Sbjct: 1863 KEAENERLRRLAEDEAFQRR-RLEEQAAQHKADIE----ERLAQLRKASDSELERQKGLV 1917
Query: 508 TEN----RLVNQRLLEVQSQVE-------ELQKSLQDQGSKAEDSVLLKKKLEEHLEKLH 556
+ R V + +L +++ E EL+ L S AED++ K++ E +
Sbjct: 1918 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1977
Query: 557 EANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIR 616
+ E +++R E+ + SL EE EA R+++ ++++ ER K +E+A R
Sbjct: 1978 QLAAEEERRRREAEERVQK----SLAAEE--EAARQRKAALEEV-ERLKAKVEEA----R 2026
Query: 617 TLDPKQNQGAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQREMEEKYIVSAWYNMGMTL 676
L + Q +A ++Q + Q+R + EK + Q+E E + + ++ L
Sbjct: 2027 RLRERAEQESARQLQLAQEAAQKR---LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2083
Query: 677 HKKAAEDRLASTGSGQSFLARQRQATSSRR 706
+A R A+ + ++ + +R+A SRR
Sbjct: 2084 RGEAEAARRAAEEAEEARVQAEREAAQSRR 2113
Score = 38.1 bits (87), Expect = 0.029
Identities = 83/424 (19%), Positives = 168/424 (39%), Gaps = 65/424 (15%)
Query: 297 QSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEE 356
Q ++ + L + L Q+ K L LRR V+L+ + + T+ EE
Sbjct: 867 QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFR-TLKPEE 925
Query: 357 ELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRLRTE 416
+ + ++ + + R + E+ A++ EY L + ++ E
Sbjct: 926 QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAER---EYGSCSHHYQQLLQSLEQGAQE 982
Query: 417 RDSLKETIEELRCVQAQEGQLTTQGL----MPLGSQESSDSLAAEIVTPEIREKLIRLQH 472
+ I EL+ ++ Q T+ + +PL + A E ++ + +
Sbjct: 983 ESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEP-----ARECAQRIAEQQKAQAEV 1037
Query: 473 ENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELE-TENRLVNQRLLEVQSQVEELQK-S 530
E + + ++ EK+ L A ++ELE T +L R L +E+L+ S
Sbjct: 1038 EGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSA-IYLEKLKTIS 1096
Query: 531 LQDQGSKAEDSVLL--KKKLEEH------LEKLHEANNELQKKRAIIEDLEPRFNNSSLK 582
L +G++ + VL +++L+E L +L L+K RA E +P F+ +
Sbjct: 1097 LVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDE 1156
Query: 583 I-------EELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQ------------- 622
+ E LQ+ +++ E+++ ER + LE+ ++V+ D +Q
Sbjct: 1157 LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY 1216
Query: 623 NQGAAP---------------------EIQALKNQLQERDRLFHSLEKEYEKTKSQREME 661
+ A P + QA++ QL++ L +E+ EK + +
Sbjct: 1217 RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1276
Query: 662 EKYI 665
++YI
Sbjct: 1277 KQYI 1280
Score = 30.8 bits (68), Expect = 4.6
Identities = 75/397 (18%), Positives = 155/397 (39%), Gaps = 49/397 (12%)
Query: 129 CEQKQEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELNEA 188
CE++ A++ + V + A ++ + V D + R L + L +
Sbjct: 412 CEEQLNQADALLQSD-----VRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDG 466
Query: 189 LSAK-EEIAQRCHELDMQVAALQEEKSSLLAEN---------QVLMERLNQSDSIEDPNS 238
+ E++ +R + L ++ A++ E + L QV ++ + + +ED
Sbjct: 467 RHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTL 526
Query: 239 PAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISE---LRQQNDELTTLADE 295
LQ L ++E R++ A ++ + +E ++ L Q +E +
Sbjct: 527 R------YLQDLLAWVEENQHRVDGA--EWGVDLPSVEAQLGSHRGLHQSIEEFRAKIER 578
Query: 296 AQSLKDEIDVLRHSS--DKVSKLEGQ----VESYKKKLEDLGDLRRQVKLLEEKNTMYMQ 349
A+S + ++ + D + +L+ Q + S K +L L L V K M++
Sbjct: 579 ARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAAT-KELMWLN 637
Query: 350 NTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKE 409
EEE+ + R+ T K++ R +L+ + K++KE LQ
Sbjct: 638 EKE--EEEVGFDWSDRNTNMTAKKESYSALMR---------ELELKEKKIKE----LQNA 682
Query: 410 KDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIR 469
DRL E + T+E + + Q + + ++ + + ++RE +
Sbjct: 683 GDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFS-DVREAEGQ 741
Query: 470 LQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNEL 506
LQ + L+ + + L+ LL DA K +L
Sbjct: 742 LQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQL 778
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 97.4 bits (241), Expect = 4e-20
Identities = 122/534 (22%), Positives = 233/534 (43%), Gaps = 68/534 (12%)
Query: 176 RQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSDSIED 235
RQ K EE+ E L AK E A+R E Q +A Q + + A+ ++ E + +++
Sbjct: 2002 RQRKAALEEV-ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2060
Query: 236 PNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADE 295
+ Q Q+ L+QL+ E A ++ + E+E ++ R+Q +E L
Sbjct: 2061 KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQS 2120
Query: 296 AQSLKDEIDVLRHSSDKVSK----------------------LEGQVESYKKKLEDLGDL 333
A+ + +++K+ K + ++E +KK E L
Sbjct: 2121 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT--L 2178
Query: 334 RRQVKLLEEKNTMYMQNTVS------LEEELRKANAARSQLETYKRQVVE----LQNRLS 383
R++ ++ +E T+ +Q + L+EEL++ A ++ + QV E ++ ++
Sbjct: 2179 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2238
Query: 384 EESKKADKLDFEYKRLKEKVDSLQKEKDR----LRTERDSLKETIEELR--CVQAQEG-- 435
E SK +++ E + L + ++KD L+ E + +K+ EE V AQE
Sbjct: 2239 ELSKLKARIEAENRAL------ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2292
Query: 436 --QLTTQGLMP---LGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSDNEKIA 490
QL + L L + + + A ++ + LQ + ++ + +K
Sbjct: 2293 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2352
Query: 491 LLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQD----QGSKAEDSVLLKK 546
+ Q L ++ + LE E QR LE+ ++ E L+ + + Q ED+ +K
Sbjct: 2353 MAQQLAEETQGFQRTLEAER----QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2408
Query: 547 KLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKK 606
+ EE EKLH Q+K +++ LE + S E L+EA+ + E E +++++ K
Sbjct: 2409 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL 2468
Query: 607 YLEKAKSVIRTLDPKQNQGAAPEIQALKNQ-LQERDRLFHSLEKEYEKTKSQRE 659
K++ + Q + E QAL+ L E+D L E+ E+ K++ E
Sbjct: 2469 LQLKSEE----MQTVQQEQLLQETQALQQSFLSEKDSLLQR-ERFIEQEKAKLE 2517
Score = 90.5 bits (223), Expect = 5e-18
Identities = 113/534 (21%), Positives = 233/534 (43%), Gaps = 57/534 (10%)
Query: 130 EQKQEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELNEAL 189
EQ Q QA E+ + A + ++++ + A ++++ K + L +
Sbjct: 2123 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2182
Query: 190 SAKEEIAQ---RCHELDMQVAALQEEKSSLLAENQVLMERLNQSDSIEDPNSPAGRRHLQ 246
++E+ + E D Q L EE L AE E Q +E+
Sbjct: 2183 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAE---ATEAARQRSQVEE-------ELFS 2232
Query: 247 LQTQLEQLQEETFRLEAAKDDYRIRCEE-----LEKEISELRQQNDE---LTTLADEAQS 298
++ Q+E+L + R+EA +R ++ L++E +++Q +E L+ A EA
Sbjct: 2233 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2292
Query: 299 LK----DEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSL 354
L+ +++ R ++K+ K + Q +L+ +L +Q K L ++ +Q
Sbjct: 2293 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ----- 2347
Query: 355 EEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRLR 414
E++ + A + + ++R + + R E S +A++L + +++ R R
Sbjct: 2348 EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR 2407
Query: 415 TERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHEN 474
+ + + E + + QE Q L Q D+ E+ + +LQ E
Sbjct: 2408 KQAEEIGEKLHRTE-LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEA 2466
Query: 475 KMLKLNQEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQ 534
K+L+L E + + + Q L + L+++ L ++ L+ QR ++ + +L++ QD+
Sbjct: 2467 KLLQLKSE--EMQTVQQEQLLQETQALQQSFLSEKDSLL-QRERFIEQEKAKLEQLFQDE 2523
Query: 535 GSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKE 594
+KA+ + EE + + E Q+ A +E+ R + E +E +R+K+
Sbjct: 2524 VAKAQ------QLREEQQRQQQQMEQERQRLVASMEEARRRQH-------EAEEGVRRKQ 2570
Query: 595 EEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRLFHSLE 648
EE++Q+E++ ++ E L ++NQ ++Q L+ Q R L HS E
Sbjct: 2571 EELQQLEQQRRQQEE--------LLAEENQRLREQLQLLEE--QHRAALAHSEE 2614
Score = 86.7 bits (213), Expect = 7e-17
Identities = 122/567 (21%), Positives = 252/567 (44%), Gaps = 53/567 (9%)
Query: 133 QEYIQAIMMMEESVQHVVMTAIQELMS---KESPVSAGNDA----YVDLDRQLKKTTEEL 185
++YI AI E +Q V A E ++ K+ V +G+++ YVDL + T
Sbjct: 1273 KQYINAIKDYE--LQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLT 1330
Query: 186 NEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQ-SDSIEDPNSPAGRRH 244
++ + E +R E + + E+ LAE + +E+ Q +++ + A R
Sbjct: 1331 SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA 1390
Query: 245 LQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQND-ELTTLADEAQS----- 298
+LQ +++QEE R E A D + + +++E+ +LRQ ++ E+ A +A++
Sbjct: 1391 KELQ---QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1447
Query: 299 --LKDEIDVLRHSSDKVSK----LEGQVESYKKKLEDLGDLRRQV--------KLLEEKN 344
+++EI V+R + + EG++++ + + E+ +RQ + +++++
Sbjct: 1448 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1507
Query: 345 TMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKR-LKEKV 403
Q V L ++ A + + + + EL+ + E ++ + + E R ++ +
Sbjct: 1508 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL 1567
Query: 404 DSLQKEKD-RLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPE 462
++ Q+ + L+++R S E +L QE + L + + AE E
Sbjct: 1568 ETAQRSAEAELQSKRASFAEKTAQLE-RSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1626
Query: 463 IREKLIRLQ-HENKMLKLNQEGSDNEKIALLQSLLD-DANLRKNELETENRLVNQRLLEV 520
+L R Q N+ L+L + E++A +SL +A +K E E E R + +
Sbjct: 1627 AERELERWQLKANEALRLRLQA---EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1683
Query: 521 QSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIED----LEPRF 576
Q E ++ L+ Q AE + + E+ L +L + +++R ++E+ L+
Sbjct: 1684 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1743
Query: 577 NNSSLKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQ 636
++ K +EL+ L K EM+ + + E+++S K Q E +
Sbjct: 1744 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRST----SEKSKQRLEAEAGRFREL 1799
Query: 637 LQERDRLFHSLEKEYEKTKSQREMEEK 663
+E R L E+ K QR++ E+
Sbjct: 1800 AEEAAR----LRALAEEAKRQRQLAEE 1822
Score = 82.0 bits (201), Expect = 2e-15
Identities = 142/630 (22%), Positives = 273/630 (43%), Gaps = 75/630 (11%)
Query: 108 EHSDAAELGRMLQLILGCAVNCEQKQEYI-QAIMMMEESVQHVVMTAIQELMSKESPVSA 166
E A E R LQ + + E+ + + QA + VQ + TA + S E+ + +
Sbjct: 1524 EAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQR---SAEAELQS 1580
Query: 167 GNDAYVDLDRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAE-----NQ 221
++ + QL+++ +E + A++ E A+R + + +EE L N+
Sbjct: 1581 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1640
Query: 222 VLMERLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISE 281
L RL Q++ + S A + + Q E+ + E R A++ +R EL ++ E
Sbjct: 1641 ALRLRL-QAEEVAQQKSLA---QAEAEKQKEEAEREARRRGKAEEQ-AVRQRELAEQ--E 1693
Query: 282 LRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLE 341
L +Q A + + + E+ LR +++ + +E E+L L+R+
Sbjct: 1694 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE------EELARLQREAAAAT 1747
Query: 342 EKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKE 401
+K LE EL K A L K + E SE+SK+ +L+ E R +E
Sbjct: 1748 QKRQ-------ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQ--RLEAEAGRFRE 1798
Query: 402 ------KVDSLQKEKDRLR--TERDSLKETIEELRCVQ------AQEGQLTTQGLMPLGS 447
++ +L +E R R E D+ ++ E R + + +L T+ + L
Sbjct: 1799 LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE 1858
Query: 448 QESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELE 507
+E+ + + E ++ RL+ + K + E E++A L+ D R+ L
Sbjct: 1859 KEAENERLRRLAEDEAFQRR-RLEEQAAQHKADIE----ERLAQLRKASDSELERQKGLV 1913
Query: 508 TEN----RLVNQRLLEVQSQVE-------ELQKSLQDQGSKAEDSVLLKKKLEEHLEKLH 556
+ R V + +L +++ E EL+ L S AED++ K++ E +
Sbjct: 1914 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1973
Query: 557 EANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIR 616
+ E +++R E+ + SL EE EA R+++ ++++ ER K +E+A R
Sbjct: 1974 QLAAEEERRRREAEERVQK----SLAAEE--EAARQRKAALEEV-ERLKAKVEEA----R 2022
Query: 617 TLDPKQNQGAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQREMEEKYIVSAWYNMGMTL 676
L + Q +A ++Q + Q+R + EK + Q+E E + + ++ L
Sbjct: 2023 RLRERAEQESARQLQLAQEAAQKR---LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2079
Query: 677 HKKAAEDRLASTGSGQSFLARQRQATSSRR 706
+A R A+ + ++ + +R+A SRR
Sbjct: 2080 RGEAEAARRAAEEAEEARVQAEREAAQSRR 2109
Score = 38.1 bits (87), Expect = 0.029
Identities = 83/424 (19%), Positives = 168/424 (39%), Gaps = 65/424 (15%)
Query: 297 QSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEE 356
Q ++ + L + L Q+ K L LRR V+L+ + + T+ EE
Sbjct: 863 QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFR-TLKPEE 921
Query: 357 ELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRLRTE 416
+ + ++ + + R + E+ A++ EY L + ++ E
Sbjct: 922 QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAER---EYGSCSHHYQQLLQSLEQGAQE 978
Query: 417 RDSLKETIEELRCVQAQEGQLTTQGL----MPLGSQESSDSLAAEIVTPEIREKLIRLQH 472
+ I EL+ ++ Q T+ + +PL + A E ++ + +
Sbjct: 979 ESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEP-----ARECAQRIAEQQKAQAEV 1033
Query: 473 ENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELE-TENRLVNQRLLEVQSQVEELQK-S 530
E + + ++ EK+ L A ++ELE T +L R L +E+L+ S
Sbjct: 1034 EGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSA-IYLEKLKTIS 1092
Query: 531 LQDQGSKAEDSVLL--KKKLEEH------LEKLHEANNELQKKRAIIEDLEPRFNNSSLK 582
L +G++ + VL +++L+E L +L L+K RA E +P F+ +
Sbjct: 1093 LVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDE 1152
Query: 583 I-------EELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQ------------- 622
+ E LQ+ +++ E+++ ER + LE+ ++V+ D +Q
Sbjct: 1153 LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY 1212
Query: 623 NQGAAP---------------------EIQALKNQLQERDRLFHSLEKEYEKTKSQREME 661
+ A P + QA++ QL++ L +E+ EK + +
Sbjct: 1213 RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1272
Query: 662 EKYI 665
++YI
Sbjct: 1273 KQYI 1276
Score = 30.8 bits (68), Expect = 4.6
Identities = 75/397 (18%), Positives = 155/397 (39%), Gaps = 49/397 (12%)
Query: 129 CEQKQEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEELNEA 188
CE++ A++ + V + A ++ + V D + R L + L +
Sbjct: 408 CEEQLNQADALLQSD-----VRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDG 462
Query: 189 LSAK-EEIAQRCHELDMQVAALQEEKSSLLAEN---------QVLMERLNQSDSIEDPNS 238
+ E++ +R + L ++ A++ E + L QV ++ + + +ED
Sbjct: 463 RHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTL 522
Query: 239 PAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISE---LRQQNDELTTLADE 295
LQ L ++E R++ A ++ + +E ++ L Q +E +
Sbjct: 523 R------YLQDLLAWVEENQHRVDGA--EWGVDLPSVEAQLGSHRGLHQSIEEFRAKIER 574
Query: 296 AQSLKDEIDVLRHSS--DKVSKLEGQ----VESYKKKLEDLGDLRRQVKLLEEKNTMYMQ 349
A+S + ++ + D + +L+ Q + S K +L L L V K M++
Sbjct: 575 ARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAAT-KELMWLN 633
Query: 350 NTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKE 409
EEE+ + R+ T K++ R +L+ + K++KE LQ
Sbjct: 634 EKE--EEEVGFDWSDRNTNMTAKKESYSALMR---------ELELKEKKIKE----LQNA 678
Query: 410 KDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIR 469
DRL E + T+E + + Q + + ++ + + ++RE +
Sbjct: 679 GDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFS-DVREAEGQ 737
Query: 470 LQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNEL 506
LQ + L+ + + L+ LL DA K +L
Sbjct: 738 LQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQL 774
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.126 0.332
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,894,673
Number of Sequences: 37866
Number of extensions: 1085569
Number of successful extensions: 22672
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 518
Number of HSP's successfully gapped in prelim test: 1320
Number of HSP's that attempted gapping in prelim test: 6887
Number of HSP's gapped (non-prelim): 6856
length of query: 718
length of database: 18,247,518
effective HSP length: 110
effective length of query: 608
effective length of database: 14,082,258
effective search space: 8562012864
effective search space used: 8562012864
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.