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Search of human proteins with 9966827
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|9966827 PEST proteolytic signal containing nuclear protein
[Homo sapiens]
(178 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|9966827 PEST proteolytic signal containing nuclear protein [H... 355 9e-99
gi|55741709 RNA binding motif protein 25 [Homo sapiens] 42 3e-04
gi|62988361 absent in melanoma 1 [Homo sapiens] 39 0.002
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens] 39 0.003
gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens] 39 0.003
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa... 38 0.004
gi|34335262 zinc finger, MYND-type containing 8 isoform a [Homo ... 37 0.007
gi|109637769 calpastatin isoform k [Homo sapiens] 37 0.009
gi|109637763 calpastatin isoform h [Homo sapiens] 37 0.009
gi|109637757 calpastatin isoform e [Homo sapiens] 37 0.009
gi|27765085 calpastatin isoform b [Homo sapiens] 37 0.009
gi|109637765 calpastatin isoform i [Homo sapiens] 37 0.012
gi|109637753 calpastatin isoform a [Homo sapiens] 37 0.012
gi|10863903 thyroid hormone receptor interactor 12 [Homo sapiens] 37 0.012
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 36 0.015
gi|51873049 hypothetical protein LOC8603 [Homo sapiens] 36 0.015
gi|45439359 triple functional domain (PTPRF interacting) [Homo s... 36 0.015
gi|55749459 transcription elongation factor A (SII)-like 4 [Homo... 35 0.026
gi|55749442 transcription elongation factor A (SII)-like 4 [Homo... 35 0.026
gi|65505873 transcription elongation factor A (SII)-like 4 [Homo... 35 0.026
gi|17933774 transcription elongation factor A (SII)-like 2 [Homo... 35 0.026
gi|55749451 transcription elongation factor A (SII)-like 4 [Homo... 35 0.026
gi|149773456 hypothetical protein LOC643314 [Homo sapiens] 35 0.034
gi|19913408 DNA topoisomerase II, beta isozyme [Homo sapiens] 35 0.034
gi|20070107 orthodenticle homeobox 1 [Homo sapiens] 35 0.034
gi|125656165 THO complex 2 [Homo sapiens] 34 0.058
gi|156104889 myeloid/lymphoid or mixed-lineage leukemia (trithor... 34 0.058
gi|55741677 SET domain containing 1A [Homo sapiens] 34 0.076
gi|5174573 myeloid/lymphoid or mixed-lineage leukemia trithorax ... 34 0.076
gi|158854042 hypothetical protein LOC222183 [Homo sapiens] 34 0.076
>gi|9966827 PEST proteolytic signal containing nuclear protein [Homo
sapiens]
Length = 178
Score = 355 bits (912), Expect = 9e-99
Identities = 178/178 (100%), Positives = 178/178 (100%)
Query: 1 MADGKAGDEKPEKSQRAGAAGGPEEEAEKPVKTKTVSSSNGGESSSRSAEKRSAEEEAAD 60
MADGKAGDEKPEKSQRAGAAGGPEEEAEKPVKTKTVSSSNGGESSSRSAEKRSAEEEAAD
Sbjct: 1 MADGKAGDEKPEKSQRAGAAGGPEEEAEKPVKTKTVSSSNGGESSSRSAEKRSAEEEAAD 60
Query: 61 LPTKPTKISKFGFAIGSQTTKKASAISIKLGSSKPKETVPTLAPKTLSVAAAFNEDEDSE 120
LPTKPTKISKFGFAIGSQTTKKASAISIKLGSSKPKETVPTLAPKTLSVAAAFNEDEDSE
Sbjct: 61 LPTKPTKISKFGFAIGSQTTKKASAISIKLGSSKPKETVPTLAPKTLSVAAAFNEDEDSE 120
Query: 121 PEEMPPEAKMRMKNIGRDTPTSAGPNSFNKGKHGFSDNQKLWERNIKSHLGNVHDQDN 178
PEEMPPEAKMRMKNIGRDTPTSAGPNSFNKGKHGFSDNQKLWERNIKSHLGNVHDQDN
Sbjct: 121 PEEMPPEAKMRMKNIGRDTPTSAGPNSFNKGKHGFSDNQKLWERNIKSHLGNVHDQDN 178
>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
Length = 843
Score = 42.0 bits (97), Expect = 3e-04
Identities = 38/157 (24%), Positives = 65/157 (41%), Gaps = 15/157 (9%)
Query: 8 DEKPEKSQRAGAAGGPEEEAEKPVKTKTVSSSNGGESSSRSAEKRSAEEEAADLPTKPTK 67
+E+ EK ++ P EE E+P + + + SS+ S S P P
Sbjct: 585 EEEEEKQEKEEKREEPMEEEEEPEQKPCLKPTLRPISSAPSVSSASGNAT----PNTPGD 640
Query: 68 ISKFGFAIGSQTT---------KKASAISIKLGSSKPKETVPTLAPKTLSVAAAFNEDED 118
S G I + + + +S+KLG+S ++ K L V + FN+ ED
Sbjct: 641 ESPCGIIIPHENSPDQQQPEEHRPKIGLSLKLGASNSPGQPNSVKRKKLPVDSVFNKFED 700
Query: 119 SEPEEMPPEAKMRMKNIGRD--TPTSAGPNSFNKGKH 153
+ +++P + K+ + G D T N+ K KH
Sbjct: 701 EDSDDVPRKRKLVPLDYGEDDKNATKGTVNTEEKRKH 737
>gi|62988361 absent in melanoma 1 [Homo sapiens]
Length = 1723
Score = 39.3 bits (90), Expect = 0.002
Identities = 44/154 (28%), Positives = 56/154 (36%), Gaps = 10/154 (6%)
Query: 2 ADGKAGDEKPEKSQRAGAAGGPEEEAEKPVKTKTVSSSNGGESSSRSAEKRSAEEEAADL 61
A A EK KS RA GG A K S G + R RS + A
Sbjct: 49 ASDNASAEKKVKSPRAALDGGVASAASPESKP-----SPGTKGQLRGESDRSKQPPPASS 103
Query: 62 PTKPTKISKFGFAIGSQTTKKASAISIKLGSSKPKETVPTLAPKTLSVAAAFNEDEDSE- 120
PTK S+ A+ + AS S PK VP +P T AA E+
Sbjct: 104 PTKRKGRSR---ALEAVPAPPASGPRAPAKESPPKR-VPDPSPVTKGTAAESGEEAARAI 159
Query: 121 PEEMPPEAKMRMKNIGRDTPTSAGPNSFNKGKHG 154
P E+P ++ + I + PN FN G
Sbjct: 160 PRELPVKSSSLLPEIKPEHKRGPLPNHFNGRAEG 193
>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
Length = 2454
Score = 38.5 bits (88), Expect = 0.003
Identities = 37/152 (24%), Positives = 61/152 (40%), Gaps = 7/152 (4%)
Query: 8 DEKPEKSQRAGAAGGPEEEAEKPVKTKTVSSSNGGESSSRSAEKRSAEEEAADLPTKPTK 67
DE E ++ G E++ K K + ESSS EK EE P K K
Sbjct: 937 DETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFP-KGIK 995
Query: 68 ISKFGFAIGSQTTKKASAISIKLGSSKPKETVPTLAPKTLSVAAAFNEDEDSEPEE-MPP 126
K G G + +KK I+ +SK K+ + A K+ + + ED + +
Sbjct: 996 QIKNGTTDGEKKSKK-----IRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYG 1050
Query: 127 EAKMRMKNIGRDTPTSAGPNSFNKGKHGFSDN 158
K R K +G+ + +S + K+ ++
Sbjct: 1051 REKKRCKLLGKSSRKRQDCSSSDTEKYSMKED 1082
>gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]
Length = 2492
Score = 38.5 bits (88), Expect = 0.003
Identities = 37/152 (24%), Positives = 61/152 (40%), Gaps = 7/152 (4%)
Query: 8 DEKPEKSQRAGAAGGPEEEAEKPVKTKTVSSSNGGESSSRSAEKRSAEEEAADLPTKPTK 67
DE E ++ G E++ K K + ESSS EK EE P K K
Sbjct: 975 DETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFP-KGIK 1033
Query: 68 ISKFGFAIGSQTTKKASAISIKLGSSKPKETVPTLAPKTLSVAAAFNEDEDSEPEE-MPP 126
K G G + +KK I+ +SK K+ + A K+ + + ED + +
Sbjct: 1034 QIKNGTTDGEKKSKK-----IRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYG 1088
Query: 127 EAKMRMKNIGRDTPTSAGPNSFNKGKHGFSDN 158
K R K +G+ + +S + K+ ++
Sbjct: 1089 REKKRCKLLGKSSRKRQDCSSSDTEKYSMKED 1120
>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
sapiens]
Length = 699
Score = 38.1 bits (87), Expect = 0.004
Identities = 36/156 (23%), Positives = 68/156 (43%), Gaps = 14/156 (8%)
Query: 2 ADGKAGDEKPEKSQRAGAAGGPEEEAEKPVKTKTVSSSNG-GESSSRSAEKRSAEEEAAD 60
+D + +E+ EK+ ++ P++ A +K S+ G ESS+ S+ S+EEE
Sbjct: 473 SDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEK 532
Query: 61 LPTKPTKISKFGFAIGSQ--TTKKASAISIKLGSSKPKETVPTLAPKTLSVAAAFNEDED 118
L K + + A G+ T + A + K+ + K+ S+ ++E
Sbjct: 533 LKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKR-KQNEA 591
Query: 119 SEPEEMPPEAKMRMKNIGRDTPTSAGPNSFNKGKHG 154
++ E P K++++ PN+F K K G
Sbjct: 592 AKEAETPQAKKIKLQT----------PNTFPKRKKG 617
Score = 37.4 bits (85), Expect = 0.007
Identities = 37/162 (22%), Positives = 56/162 (34%), Gaps = 24/162 (14%)
Query: 1 MADGKAGDEKPEKSQRAGAAGGPEEEA---------------EKPVKTKTVSSSNGGESS 45
+A+GKA S + + EE+A + PVK T + S
Sbjct: 209 IANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSE 268
Query: 46 SRSAEKRSAEEEAADLPTKPTKISKFGFAIGSQTTKKASAISIKLGSSKPKETVPTLAPK 105
S+++ EE+ + KP S S A LG+ PK+ V P
Sbjct: 269 DSSSDEE--EEQKKPMKNKPGPYS-------SVPPPSAPPPKKSLGTQPPKKAVEKQQPV 319
Query: 106 TLSVAAAFNEDEDSEPEEMPPEAKMRMKNIGRDTPTSAGPNS 147
S ++ D SE E+ PP + K + P S
Sbjct: 320 ESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAES 361
Score = 34.3 bits (77), Expect = 0.058
Identities = 38/151 (25%), Positives = 62/151 (41%), Gaps = 27/151 (17%)
Query: 8 DEKPEKSQRAGAAGGPEEEAEKPVKTKTVSSSNGGESSSRSAEKRS-----------AEE 56
DE+ +K Q P+ +A K K SS + +SSS ++ A+
Sbjct: 137 DEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQT 196
Query: 57 EAADLPTKPTKISKFGFAIGSQTTKKASAIS----IKLGSSKPKETV---------PTLA 103
+A P + G A S ++ +S+ S + ++ PK+TV P A
Sbjct: 197 KAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKA 256
Query: 104 PKTLSVAAAFNEDEDSEPEEMPPEAKMRMKN 134
T + ++ +ED S+ EE E K MKN
Sbjct: 257 ATTPTRKSSSSEDSSSDEEE---EQKKPMKN 284
Score = 31.6 bits (70), Expect = 0.38
Identities = 37/147 (25%), Positives = 58/147 (39%), Gaps = 14/147 (9%)
Query: 6 AGDEKPEKSQRAGAAGGPEEEAEKPVKTKTVSSSNGGESSSRSAEKRSAEEEAADLPTKP 65
AG K ++ A P A KP G + +R A+ S+EEE++ +
Sbjct: 381 AGTTKNSSNKPAVTTKSP---AVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEK 437
Query: 66 TKISKFGFAIGSQTTKKASAISIKLGSSKPKETVPTLAPKTLSVAAAFNEDEDSEPEEMP 125
TK + + T KA+A K S P + P + + S + + + +E+ E
Sbjct: 438 TK------KMVATTKPKATA---KAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKS 488
Query: 126 PEAKMRMKNIGRDTPTSAGPNSFNKGK 152
K K G P+ P S KGK
Sbjct: 489 AVKKKPQKVAGGAAPSK--PASAKKGK 513
Score = 30.4 bits (67), Expect = 0.84
Identities = 22/92 (23%), Positives = 39/92 (42%)
Query: 2 ADGKAGDEKPEKSQRAGAAGGPEEEAEKPVKTKTVSSSNGGESSSRSAEKRSAEEEAADL 61
++ ++ + EK+++ A P+ A+ + + G SS ++ S+EEE
Sbjct: 426 SEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKT 485
Query: 62 PTKPTKISKFGFAIGSQTTKKASAISIKLGSS 93
K A G+ +K ASA K SS
Sbjct: 486 SKSAVKKKPQKVAGGAAPSKPASAKKGKAESS 517
>gi|34335262 zinc finger, MYND-type containing 8 isoform a [Homo
sapiens]
Length = 1188
Score = 37.4 bits (85), Expect = 0.007
Identities = 34/146 (23%), Positives = 57/146 (39%), Gaps = 14/146 (9%)
Query: 19 AAGGPEEEAEKPVKTKTVSSSNGGESSSRSAEKRSAEEEAADLPTKPTKISKFGFAI--- 75
+A P++EA+ V T+T++ S+ G SSS + + + T K + G +
Sbjct: 1039 SATAPQQEADAEVNTETLNKSSQGSSSSTQSAPSETASASKEKETSAEKSKESGSTLDLS 1098
Query: 76 GSQTTKKASAISIKLGS-SKPKETVPTLAPKTLSVAAAFNEDEDSEPEEMPPEAKMRMKN 134
GS+ T + + GS SK + P AP T D +P P K ++
Sbjct: 1099 GSRETPSSILLGSNQGSVSKRCDKQPAYAPTT----------TDHQPHPNYPAQKYHSRS 1148
Query: 135 IGRDTPTSAGPNSFNKGKHGFSDNQK 160
+S + H S + K
Sbjct: 1149 NKSSWSSSDEKRGSTRSDHNTSTSTK 1174
>gi|109637769 calpastatin isoform k [Homo sapiens]
Length = 673
Score = 37.0 bits (84), Expect = 0.009
Identities = 25/103 (24%), Positives = 46/103 (44%), Gaps = 10/103 (9%)
Query: 5 KAGDEKPEKS----------QRAGAAGGPEEEAEKPVKTKTVSSSNGGESSSRSAEKRSA 54
KA +PEK ++ G P+E E K S + ++ ++ A RSA
Sbjct: 7 KAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSA 66
Query: 55 EEEAADLPTKPTKISKFGFAIGSQTTKKASAISIKLGSSKPKE 97
E++ ++ T+P + + G ++ +AIS K G K ++
Sbjct: 67 EQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEK 109
>gi|109637763 calpastatin isoform h [Homo sapiens]
Length = 769
Score = 37.0 bits (84), Expect = 0.009
Identities = 25/103 (24%), Positives = 46/103 (44%), Gaps = 10/103 (9%)
Query: 5 KAGDEKPEKS----------QRAGAAGGPEEEAEKPVKTKTVSSSNGGESSSRSAEKRSA 54
KA +PEK ++ G P+E E K S + ++ ++ A RSA
Sbjct: 90 KAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSA 149
Query: 55 EEEAADLPTKPTKISKFGFAIGSQTTKKASAISIKLGSSKPKE 97
E++ ++ T+P + + G ++ +AIS K G K ++
Sbjct: 150 EQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEK 192
Score = 32.0 bits (71), Expect = 0.29
Identities = 41/150 (27%), Positives = 54/150 (36%), Gaps = 19/150 (12%)
Query: 5 KAGDEKPEKSQRAGAAGGPEEE---AEKPVKTKTVSSSNGGESSSRSAEKRSAEEEAADL 61
K G++K ++A + G + A VS+S+G S S S E +
Sbjct: 37 KPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSSMNPT----ETKAV 92
Query: 62 PTKPTKISKFGFAIGSQTTKKASAISIKLGSSKPKE-TVPTLAPKTLSVAA---AFNEDE 117
T+P K SQ+TK + K KPKE T P PK S A N+
Sbjct: 93 KTEPEK--------KSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKA 144
Query: 118 DSEPEEMPPEAKMRMKNIGRDTPTSAGPNS 147
S E P K SAG S
Sbjct: 145 VSRSAEQQPSEKSTEPKTKPQDMISAGGES 174
>gi|109637757 calpastatin isoform e [Homo sapiens]
Length = 756
Score = 37.0 bits (84), Expect = 0.009
Identities = 25/103 (24%), Positives = 46/103 (44%), Gaps = 10/103 (9%)
Query: 5 KAGDEKPEKS----------QRAGAAGGPEEEAEKPVKTKTVSSSNGGESSSRSAEKRSA 54
KA +PEK ++ G P+E E K S + ++ ++ A RSA
Sbjct: 90 KAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSA 149
Query: 55 EEEAADLPTKPTKISKFGFAIGSQTTKKASAISIKLGSSKPKE 97
E++ ++ T+P + + G ++ +AIS K G K ++
Sbjct: 150 EQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEK 192
Score = 32.0 bits (71), Expect = 0.29
Identities = 41/150 (27%), Positives = 54/150 (36%), Gaps = 19/150 (12%)
Query: 5 KAGDEKPEKSQRAGAAGGPEEE---AEKPVKTKTVSSSNGGESSSRSAEKRSAEEEAADL 61
K G++K ++A + G + A VS+S+G S S S E +
Sbjct: 37 KPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSSMNPT----ETKAV 92
Query: 62 PTKPTKISKFGFAIGSQTTKKASAISIKLGSSKPKE-TVPTLAPKTLSVAA---AFNEDE 117
T+P K SQ+TK + K KPKE T P PK S A N+
Sbjct: 93 KTEPEK--------KSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKA 144
Query: 118 DSEPEEMPPEAKMRMKNIGRDTPTSAGPNS 147
S E P K SAG S
Sbjct: 145 VSRSAEQQPSEKSTEPKTKPQDMISAGGES 174
>gi|27765085 calpastatin isoform b [Homo sapiens]
Length = 686
Score = 37.0 bits (84), Expect = 0.009
Identities = 25/103 (24%), Positives = 46/103 (44%), Gaps = 10/103 (9%)
Query: 5 KAGDEKPEKS----------QRAGAAGGPEEEAEKPVKTKTVSSSNGGESSSRSAEKRSA 54
KA +PEK ++ G P+E E K S + ++ ++ A RSA
Sbjct: 7 KAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSA 66
Query: 55 EEEAADLPTKPTKISKFGFAIGSQTTKKASAISIKLGSSKPKE 97
E++ ++ T+P + + G ++ +AIS K G K ++
Sbjct: 67 EQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEK 109
>gi|109637765 calpastatin isoform i [Homo sapiens]
Length = 708
Score = 36.6 bits (83), Expect = 0.012
Identities = 20/83 (24%), Positives = 40/83 (48%)
Query: 15 QRAGAAGGPEEEAEKPVKTKTVSSSNGGESSSRSAEKRSAEEEAADLPTKPTKISKFGFA 74
++ G P+E E K S + ++ ++ A RSAE++ ++ T+P + +
Sbjct: 49 EKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMIS 108
Query: 75 IGSQTTKKASAISIKLGSSKPKE 97
G ++ +AIS K G K ++
Sbjct: 109 AGGESVAGITAISGKPGDKKKEK 131
>gi|109637753 calpastatin isoform a [Homo sapiens]
Length = 791
Score = 36.6 bits (83), Expect = 0.012
Identities = 20/83 (24%), Positives = 40/83 (48%)
Query: 15 QRAGAAGGPEEEAEKPVKTKTVSSSNGGESSSRSAEKRSAEEEAADLPTKPTKISKFGFA 74
++ G P+E E K S + ++ ++ A RSAE++ ++ T+P + +
Sbjct: 132 EKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMIS 191
Query: 75 IGSQTTKKASAISIKLGSSKPKE 97
G ++ +AIS K G K ++
Sbjct: 192 AGGESVAGITAISGKPGDKKKEK 214
>gi|10863903 thyroid hormone receptor interactor 12 [Homo sapiens]
Length = 1992
Score = 36.6 bits (83), Expect = 0.012
Identities = 25/87 (28%), Positives = 43/87 (49%), Gaps = 4/87 (4%)
Query: 14 SQRAGAAGGPEEEAEKPVKTKTVSSSNGGESSSRSAEKRSAEEEAADLPTKPTKISKFGF 73
++++GA GG + K ++ V S +G ES+ AE+RSA + L +K +K G
Sbjct: 135 TRKSGATGGSRSQKRKRTESSCVKSGSGSEST--GAEERSA--KPTKLASKSATSAKAGC 190
Query: 74 AIGSQTTKKASAISIKLGSSKPKETVP 100
+ + ++ AS S + TVP
Sbjct: 191 STITDSSSAASTSSSSSAVASASSTVP 217
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 36.2 bits (82), Expect = 0.015
Identities = 39/142 (27%), Positives = 58/142 (40%), Gaps = 19/142 (13%)
Query: 7 GDEKPEKSQRAGAAGGPEEEAEKPVKTKTVSSSNGGESSSRSAEKRSAEEEAADLPTKPT 66
G E+ KS A A PE+EA+ PVK E + AE +S E+E A P +
Sbjct: 496 GGEEETKSPPAEEAASPEKEAKSPVK----------EEAKSPAEAKSPEKEEAKSPAEVK 545
Query: 67 KISKFGFAIGSQTTKKASAISIKLGSSKPKETVPTLAP-KTLSVAAAFNEDEDSEPEE-- 123
K +++ K A S S KE + A K+ A + ++E P E
Sbjct: 546 SPEK------AKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAK 599
Query: 124 MPPEAKMRMKNIGRDTPTSAGP 145
P +AK +K + + P
Sbjct: 600 SPEKAKSPVKEEAKSPAEAKSP 621
Score = 29.6 bits (65), Expect = 1.4
Identities = 30/123 (24%), Positives = 47/123 (38%), Gaps = 20/123 (16%)
Query: 8 DEKPEKSQ-RAGAAGGPEEEAEKPVKTKTVSSSNGGESSSRSAEKRSAEEEAADLPTKPT 66
+EKP++ + + EE+A KT+ S E+ + A K EE+ KP
Sbjct: 827 EEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKP- 885
Query: 67 KISKFGFAIGSQTTKKASAISIKLGSSKPKETVPTLAPKTLSVAAAFNEDEDSEPEEMPP 126
K S + K ++ K+ VPT A ED++P+E
Sbjct: 886 ---------------KESKVEAKKEEAEDKKKVPT---PEKEAPAKVEVKEDAKPKEKTE 927
Query: 127 EAK 129
AK
Sbjct: 928 VAK 930
Score = 26.9 bits (58), Expect = 9.2
Identities = 22/103 (21%), Positives = 34/103 (33%), Gaps = 6/103 (5%)
Query: 25 EEAEKPVKTKTVSSSNGGESSSRSAEKRSAEEEAADLPTKPTKISKFGFAIGSQTTKKAS 84
EE EK K + GGE + + A+ P K +K S ++A
Sbjct: 472 EEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAK------SPVKEEAK 525
Query: 85 AISIKLGSSKPKETVPTLAPKTLSVAAAFNEDEDSEPEEMPPE 127
+ + K + P + E+ S PE PE
Sbjct: 526 SPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPE 568
>gi|51873049 hypothetical protein LOC8603 [Homo sapiens]
Length = 1224
Score = 36.2 bits (82), Expect = 0.015
Identities = 29/124 (23%), Positives = 47/124 (37%), Gaps = 4/124 (3%)
Query: 42 GESSSRSAEKRSAEEEAADLPTKPTKISKFGFAIGSQTTKKASAISIKLGSSKPKETVPT 101
G + + A E A PT+P K ++ +QT KA + + + + +E
Sbjct: 1043 GNGKQKLRQTSKASSEPARRPTEPPKATEGQSKPRAQTESKAKVVDLMSITEQKREERKV 1102
Query: 102 LAPKTLSVAAAFNEDEDSEPEEMPP----EAKMRMKNIGRDTPTSAGPNSFNKGKHGFSD 157
+ +DE S P M P E + K + ++P G N NK K G
Sbjct: 1103 NSNNNNKKQLNHIKDEKSNPTPMEPTSPGEHQQNSKLVLAESPQPKGKNKKNKKKKGDRV 1162
Query: 158 NQKL 161
N +
Sbjct: 1163 NNSI 1166
>gi|45439359 triple functional domain (PTPRF interacting) [Homo
sapiens]
Length = 3097
Score = 36.2 bits (82), Expect = 0.015
Identities = 37/146 (25%), Positives = 53/146 (36%), Gaps = 15/146 (10%)
Query: 5 KAGDEKPEKSQRAGAAGGPEEEAEKPVKTKTVSSSNGGESSSRSAEKRSAEEEAADLPTK 64
+AG P + A G E EAE K K + S G + +A + D P K
Sbjct: 2384 EAGPSAPSRRPPGADAEGSEREAEPIPKMKVLESPRKGAA--------NASGSSPDAPAK 2435
Query: 65 PTKISKFGFAIGSQTTKKASAISIKLGSSKP---KETVPTLAPKTLSVAAAFNEDEDSEP 121
+ S +G AS ++ L S+ P KE P +P L +F + P
Sbjct: 2436 DARASLGTLPLGKPRAGAASPLNSPLSSAVPSLGKEPFPPSSP--LQKGGSFWSSIPASP 2493
Query: 122 EEMPPEAKM--RMKNIGRDTPTSAGP 145
P ++ R TP A P
Sbjct: 2494 ASRPGSFTFPGDSDSLQRQTPRHAAP 2519
>gi|55749459 transcription elongation factor A (SII)-like 4 [Homo
sapiens]
Length = 215
Score = 35.4 bits (80), Expect = 0.026
Identities = 23/73 (31%), Positives = 38/73 (52%), Gaps = 4/73 (5%)
Query: 2 ADGKAGDEKPEKSQRAGAAGGPEEEAEKPVKTKTVSSSNGGESSSRSAEKRSAEEEAADL 61
++G+A + K E+ + GG E E + ++ K S G S +R+A KR AE+ D+
Sbjct: 67 SEGEAKEGKSEREGESEMEGGSEREGKPEIEGKPESEGEPG-SETRAAGKRPAED---DV 122
Query: 62 PTKPTKISKFGFA 74
P K + + G A
Sbjct: 123 PRKAKRKTNKGLA 135
>gi|55749442 transcription elongation factor A (SII)-like 4 [Homo
sapiens]
Length = 215
Score = 35.4 bits (80), Expect = 0.026
Identities = 23/73 (31%), Positives = 38/73 (52%), Gaps = 4/73 (5%)
Query: 2 ADGKAGDEKPEKSQRAGAAGGPEEEAEKPVKTKTVSSSNGGESSSRSAEKRSAEEEAADL 61
++G+A + K E+ + GG E E + ++ K S G S +R+A KR AE+ D+
Sbjct: 67 SEGEAKEGKSEREGESEMEGGSEREGKPEIEGKPESEGEPG-SETRAAGKRPAED---DV 122
Query: 62 PTKPTKISKFGFA 74
P K + + G A
Sbjct: 123 PRKAKRKTNKGLA 135
>gi|65505873 transcription elongation factor A (SII)-like 4 [Homo
sapiens]
Length = 215
Score = 35.4 bits (80), Expect = 0.026
Identities = 23/73 (31%), Positives = 38/73 (52%), Gaps = 4/73 (5%)
Query: 2 ADGKAGDEKPEKSQRAGAAGGPEEEAEKPVKTKTVSSSNGGESSSRSAEKRSAEEEAADL 61
++G+A + K E+ + GG E E + ++ K S G S +R+A KR AE+ D+
Sbjct: 67 SEGEAKEGKSEREGESEMEGGSEREGKPEIEGKPESEGEPG-SETRAAGKRPAED---DV 122
Query: 62 PTKPTKISKFGFA 74
P K + + G A
Sbjct: 123 PRKAKRKTNKGLA 135
>gi|17933774 transcription elongation factor A (SII)-like 2 [Homo
sapiens]
Length = 227
Score = 35.4 bits (80), Expect = 0.026
Identities = 25/74 (33%), Positives = 34/74 (45%), Gaps = 10/74 (13%)
Query: 1 MADGKAGDEKPEKSQRAGAAGGPEEEAEKPVKTKTVSSSNGGESSSRSAEKRSAEEEAAD 60
M G + KPE+ RA G P+ E E S ES +R+A KR AE+ D
Sbjct: 84 MQGGSKTEGKPERGGRAEGEGEPDSEREP-------ESEGEPESETRAAGKRPAED---D 133
Query: 61 LPTKPTKISKFGFA 74
+P K + + G A
Sbjct: 134 IPRKAKRKTNKGLA 147
>gi|55749451 transcription elongation factor A (SII)-like 4 [Homo
sapiens]
Length = 215
Score = 35.4 bits (80), Expect = 0.026
Identities = 23/73 (31%), Positives = 38/73 (52%), Gaps = 4/73 (5%)
Query: 2 ADGKAGDEKPEKSQRAGAAGGPEEEAEKPVKTKTVSSSNGGESSSRSAEKRSAEEEAADL 61
++G+A + K E+ + GG E E + ++ K S G S +R+A KR AE+ D+
Sbjct: 67 SEGEAKEGKSEREGESEMEGGSEREGKPEIEGKPESEGEPG-SETRAAGKRPAED---DV 122
Query: 62 PTKPTKISKFGFA 74
P K + + G A
Sbjct: 123 PRKAKRKTNKGLA 135
>gi|149773456 hypothetical protein LOC643314 [Homo sapiens]
Length = 1427
Score = 35.0 bits (79), Expect = 0.034
Identities = 37/127 (29%), Positives = 52/127 (40%), Gaps = 15/127 (11%)
Query: 11 PEKSQRAGAAGGPEEEAEKPVKTKTVSSSNGGESSSRSAEKRSAEEE---AADLPTKPTK 67
PE+S A A EE+ P + ES+S +A + EE AA +PT
Sbjct: 1153 PEESASAAVAVPTPEESASPAAAVPTPA----ESASFAAVVATLEEPTSPAASVPTPAAM 1208
Query: 68 IS---KFGFAIGSQTTKK-----ASAISIKLGSSKPKETVPTLAPKTLSVAAAFNEDEDS 119
++ +F S T + A+A+S + P VPTL T S AA +E S
Sbjct: 1209 VATLEEFTSPAASVPTSEEPASLAAAVSNPEEPTSPAAAVPTLEEPTSSAAAVLTPEELS 1268
Query: 120 EPEEMPP 126
P P
Sbjct: 1269 SPAASVP 1275
>gi|19913408 DNA topoisomerase II, beta isozyme [Homo sapiens]
Length = 1621
Score = 35.0 bits (79), Expect = 0.034
Identities = 43/170 (25%), Positives = 66/170 (38%), Gaps = 8/170 (4%)
Query: 12 EKSQRAGAAGGPEEEAEKPVKTKTVSSSNGGESSSRSAEKRSAEEEAADLPTKPTKISKF 71
+K + + G + EK + K S G S S ++S ++ A + S F
Sbjct: 1412 DKDEYTFSPGKSKATPEKSLHDKK-SQDFGNLFSFPSYSQKSEDDSAKFDSNEEDSASVF 1470
Query: 72 GFAIGSQTTKKASAISIKLGSSKPK-ETVPT--LAPKTLSVAAAFNEDEDSEPEEMPPEA 128
+ G + T K + ++ KP +TVP APK V A N D DS E P+
Sbjct: 1471 SPSFGLKQTDKVPSKTVAAKKGKPSSDTVPKPKRAPKQKKVVEAVNSDSDS--EFGIPKK 1528
Query: 129 KMRMKNIGRDTPTSAGPNSFNKGKHGFSDNQKLWERNIKSHLGNVHDQDN 178
K GR S N+G ++ +K + K DQD+
Sbjct: 1529 TTTPKGKGRGAKKRKASGSENEG--DYNPGRKTSKTTSKKPKKTSFDQDS 1576
>gi|20070107 orthodenticle homeobox 1 [Homo sapiens]
Length = 354
Score = 35.0 bits (79), Expect = 0.034
Identities = 31/146 (21%), Positives = 56/146 (38%), Gaps = 15/146 (10%)
Query: 10 KPEKSQRAGAAGGPEEEAEKPVKTKTVSSSNGGESSSRSAEKRSAEEEAADLPTKPTKIS 69
+ ++ +G P ++ PV+ + S S+G + + S+ A+ P +
Sbjct: 94 RQQQQSGSGTKSRPAKKKSSPVRESSGSESSGQFTPPAVSSSASSSSSASSSSANPAAAA 153
Query: 70 KFGFAIGSQTTKKASAISIKLGSS--KPKETVPTLAPKTLSVAAAFNEDEDSEPEEMPPE 127
G +G AS++S SS P P AP ++SV EP P
Sbjct: 154 AAG--LGGNPVAAASSLSTPAASSIWSPASISPGSAPASVSV---------PEPLAAPSN 202
Query: 128 AKMRMKNIGRDTPTSAG--PNSFNKG 151
+++ T+A P S+ +G
Sbjct: 203 TSCMQRSVAAGAATAAASYPMSYGQG 228
>gi|125656165 THO complex 2 [Homo sapiens]
Length = 1593
Score = 34.3 bits (77), Expect = 0.058
Identities = 35/164 (21%), Positives = 61/164 (37%), Gaps = 11/164 (6%)
Query: 14 SQRAGAAGGPEEEAEKPVKTKTVSSSNGGESSSRSAEKRSAEEEAADLPTKPT-KISKFG 72
S + G GGP + + + + S + E + +S E+ +A + + T K +
Sbjct: 1199 SVQNGPGGGPSSSS---IGSASKSDESSTEETDKSRERSQCGVKAVNKASSTTPKGNSSN 1255
Query: 73 FAIGSQTTKKASAISIKLGSSKPKETVPTLAPKTLSVAAAFNEDEDSEPEEMPPEAKMRM 132
GS + K + G K KE P T A +D +P+E P +
Sbjct: 1256 GNSGSNSNKAVKENDKEKGKEKEKEKKEK-TPATTPEARVLGKDGKEKPKEERPNKDEKA 1314
Query: 133 KNIGRDTPTSAGPNSFNKGKHGFSDNQKLWERNIKSHLGNVHDQ 176
+ TP S +K K F +K + K+ + N +
Sbjct: 1315 RETKERTPKS------DKEKEKFKKEEKAKDEKFKTTVPNAESK 1352
>gi|156104889 myeloid/lymphoid or mixed-lineage leukemia (trithorax
homolog, Drosophila); translocated to, 3 [Homo sapiens]
Length = 568
Score = 34.3 bits (77), Expect = 0.058
Identities = 32/131 (24%), Positives = 54/131 (41%), Gaps = 12/131 (9%)
Query: 5 KAGDEKPEKSQRAGAAGGPEEEAEKPVKTKTVSSSNGGESSSRSAEKRSAEEEAADLPTK 64
KAG + P +S ++ + + + SSS+ SSS S+ S+ ++ +K
Sbjct: 137 KAGGD-PNRSIHTSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTSFSK 195
Query: 65 PTKISKFGFAIGSQTTKKASAI----------SIKLGSSKPKETVPTLAPKTLSVAAAFN 114
P K+ K S+ +++ + S K S KPKE P L + + AF
Sbjct: 196 PHKLMKEHKEKPSKDSREHKSAFKEPSRDHNKSSKESSKKPKENKP-LKEEKIVPKMAFK 254
Query: 115 EDEDSEPEEMP 125
E + E P
Sbjct: 255 EPKPMSKEPKP 265
>gi|55741677 SET domain containing 1A [Homo sapiens]
Length = 1707
Score = 33.9 bits (76), Expect = 0.076
Identities = 33/155 (21%), Positives = 58/155 (37%), Gaps = 18/155 (11%)
Query: 4 GKAGDEKPEKSQRAGAAGGPEEEA----EKPVKTKTVSSSNGGESSSRSAEKRSAEEEAA 59
G+ G + P++ + G G ++ + + SSS E E+ EEA
Sbjct: 935 GRPGTKPPKRDEERGKTQGKHRKSFALDSEGEEASQESSSEKDEEDDEEDEEDEDREEAV 994
Query: 60 DLPTKPTKI-----------SKFGFAIGSQTTKKASAISIKLGSSKPKETVPTLAPKTLS 108
D K T++ SK S +++ S SS + + + + S
Sbjct: 995 DTTKKETEVSDGEDEESDSSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSS 1054
Query: 109 VAAAFNEDEDSEPEEMP---PEAKMRMKNIGRDTP 140
+++ + ED E EE P P A + + TP
Sbjct: 1055 SSSSESSSEDEEEEERPAALPSASPPPREVPVPTP 1089
Score = 28.5 bits (62), Expect = 3.2
Identities = 29/127 (22%), Positives = 48/127 (37%), Gaps = 17/127 (13%)
Query: 22 GPEEEAEKPVKTKTVSSSNGGESSSRSAEKRSAEEEAADLPTKPTKISKFGFAIGSQTTK 81
G +EE++ K + S+G S+ +E S+ ++ + + S + S +
Sbjct: 1006 GEDEESDSSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDE 1065
Query: 82 KASAISIKLGSSKP---KETVPTLAPKTLSV--------AAAFNEDEDS------EPEEM 124
+ L S+ P + VPT AP + V E E S EE
Sbjct: 1066 EEEERPAALPSASPPPREVPVPTPAPVEVPVPERVAGSPVTPLPEQEASPARPAGPTEES 1125
Query: 125 PPEAKMR 131
PP A +R
Sbjct: 1126 PPSAPLR 1132
Score = 27.3 bits (59), Expect = 7.1
Identities = 19/64 (29%), Positives = 29/64 (45%), Gaps = 3/64 (4%)
Query: 5 KAGDEKPEKSQRAGAAG---GPEEEAEKPVKTKTVSSSNGGESSSRSAEKRSAEEEAADL 61
+A + KP++ Q+ G G EE E+ ++ SSS+ GE + R RS
Sbjct: 1345 EAEEPKPQQLQQQREEGEEEGEEEGEEEEEESSDSSSSSDGEGALRRRSLRSHARRRRPP 1404
Query: 62 PTKP 65
P P
Sbjct: 1405 PPPP 1408
>gi|5174573 myeloid/lymphoid or mixed-lineage leukemia trithorax
homolog 2 [Homo sapiens]
Length = 1210
Score = 33.9 bits (76), Expect = 0.076
Identities = 42/175 (24%), Positives = 66/175 (37%), Gaps = 16/175 (9%)
Query: 9 EKPEKSQRAGAAGGPEEEAEKPVKTKTVSSSNGGESSSRSAEKRSAEEEAADLPTKPTKI 68
+ P K R A E+ + P K S +SSS+ A+KR E E D K ++
Sbjct: 775 QPPGKGSRQRKA----EDKQPPAGKKHSSEKRSSDSSSKLAKKRKGEAE-RDCDNKKIRL 829
Query: 69 SKFGFAIGSQTTKKASAISIKLGSSKPKETVPTLAPKTLSVAAAFNEDEDSEPEEMPPEA 128
K I SQ++ +S+ SSK K + P+ + S+ P
Sbjct: 830 EK---EIKSQSSSSSSS---HKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALK 883
Query: 129 KMRMK--NIGRDTPTSAGPNSFNKGKHGFSDNQKL---WERNIKSHLGNVHDQDN 178
+ R + G+D P SA N +++ R+ H G+ D N
Sbjct: 884 RSRREADTCGQDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTAN 938
Score = 27.7 bits (60), Expect = 5.4
Identities = 31/147 (21%), Positives = 56/147 (38%), Gaps = 20/147 (13%)
Query: 8 DEKPEKSQRAGAAGGPEEEAEKPVKTKTVSSSNG-------------GESSSRSAEKRSA 54
++ PEK + A + +PV + SS+ ESSS +E+
Sbjct: 438 EQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEP 497
Query: 55 EEEAADLPTKPTKISKFGFAIGSQTTKKASAISIKLGSSKPKETVPTLA-PKTLSVAAAF 113
E A P PT + + + TK + + G P+ T P P++ + +
Sbjct: 498 LETPAPEPEPPTTNK---WQLDNWLTKVSQPAAPPEG---PRSTEPPRRHPESKGSSDSA 551
Query: 114 NEDEDSEPEEMPPEAKMRMKNIGRDTP 140
E SE ++ PP++ + + P
Sbjct: 552 TSQEHSESKDPPPKSSSKAPRAPPEAP 578
>gi|158854042 hypothetical protein LOC222183 [Homo sapiens]
Length = 653
Score = 33.9 bits (76), Expect = 0.076
Identities = 26/82 (31%), Positives = 35/82 (42%), Gaps = 13/82 (15%)
Query: 4 GKAGDEKPEKSQRA---------GAAGGPEEEAEK----PVKTKTVSSSNGGESSSRSAE 50
GK E+P +++ A G GGPE ++ P SS + +S SRSAE
Sbjct: 455 GKRAKERPPRARPASTSPSPGAHGRRGGPEGKSSSRSPGPHPRSWSSSRSPSKSRSRSAE 514
Query: 51 KRSAEEEAADLPTKPTKISKFG 72
KR + P KP K G
Sbjct: 515 KRPHSPSRSPSPKKPLSRDKDG 536
Score = 27.7 bits (60), Expect = 5.4
Identities = 23/121 (19%), Positives = 42/121 (34%), Gaps = 9/121 (7%)
Query: 6 AGDEKPEKSQRAGAAGGPEEEAEKPVKTKTVSSSNGGESSSRSAEKRSAEEEAADLPTKP 65
+ P KS+ A P + P K +S GE +R +E + T+
Sbjct: 500 SSSRSPSKSRSRSAEKRPHSPSRSPSPKKPLSRDKDGEGRARHSEAEA---------TRA 550
Query: 66 TKISKFGFAIGSQTTKKASAISIKLGSSKPKETVPTLAPKTLSVAAAFNEDEDSEPEEMP 125
+ S+ I + S + + +S K +P P S ++ + D +
Sbjct: 551 RRRSRSYSPIRKRRRDSPSFMEPRRITSARKRPIPYYRPSPSSSSSCLSSDYSTRSHSRS 610
Query: 126 P 126
P
Sbjct: 611 P 611
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.300 0.120 0.325
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 7,673,192
Number of Sequences: 37866
Number of extensions: 351563
Number of successful extensions: 2313
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 89
Number of HSP's successfully gapped in prelim test: 234
Number of HSP's that attempted gapping in prelim test: 1893
Number of HSP's gapped (non-prelim): 584
length of query: 178
length of database: 18,247,518
effective HSP length: 96
effective length of query: 82
effective length of database: 14,612,382
effective search space: 1198215324
effective search space used: 1198215324
T: 11
A: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.7 bits)
S2: 58 (26.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.