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Search of human proteins with 9507143
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|9507143 G protein-coupled receptor 173 [Homo sapiens]
(373 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|9507143 G protein-coupled receptor 173 [Homo sapiens] 771 0.0
gi|226342980 G protein-coupled receptor 85 [Homo sapiens] 496 e-140
gi|226342978 G protein-coupled receptor 85 [Homo sapiens] 496 e-140
gi|226342976 G protein-coupled receptor 85 [Homo sapiens] 496 e-140
gi|153266936 G protein-coupled receptor 85 [Homo sapiens] 496 e-140
gi|9506747 G protein-coupled receptor 27 [Homo sapiens] 399 e-111
gi|89191861 dopamine receptor D3 isoform a [Homo sapiens] 89 5e-18
gi|10835175 5-hydroxytryptamine (serotonin) receptor 2A [Homo sa... 89 8e-18
gi|28875799 cholecystokinin B receptor [Homo sapiens] 86 4e-17
gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens] 85 1e-16
gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens] 85 1e-16
gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens] 85 1e-16
gi|222080049 5-hydroxytryptamine (serotonin) receptor 2B [Homo s... 85 1e-16
gi|4502607 cholecystokinin A receptor [Homo sapiens] 83 3e-16
gi|89191863 dopamine receptor D3 isoform e [Homo sapiens] 82 1e-15
gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo sa... 80 2e-15
gi|4504541 5-hydroxytryptamine (serotonin) receptor 2C [Homo sap... 79 5e-15
gi|4557265 beta-1-adrenergic receptor [Homo sapiens] 77 3e-14
gi|4503907 galanin receptor 3 [Homo sapiens] 76 4e-14
gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens] 76 6e-14
gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens] 76 6e-14
gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens] 76 6e-14
gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens] 76 6e-14
gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo sa... 75 1e-13
gi|5174595 melatonin receptor 1B [Homo sapiens] 75 1e-13
gi|194353970 alpha-2A-adrenergic receptor [Homo sapiens] 75 1e-13
gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo sap... 74 2e-13
gi|71773208 alpha-2C-adrenergic receptor [Homo sapiens] 74 3e-13
gi|13236497 5-hydroxytryptamine receptor 5A [Homo sapiens] 74 3e-13
gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo sap... 74 3e-13
>gi|9507143 G protein-coupled receptor 173 [Homo sapiens]
Length = 373
Score = 771 bits (1992), Expect = 0.0
Identities = 373/373 (100%), Positives = 373/373 (100%)
Query: 1 MANTTGEPEEVSGALSPPSASAYVKLVLLGLIMCVSLAGNAILSLLVLKERALHKAPYYF 60
MANTTGEPEEVSGALSPPSASAYVKLVLLGLIMCVSLAGNAILSLLVLKERALHKAPYYF
Sbjct: 1 MANTTGEPEEVSGALSPPSASAYVKLVLLGLIMCVSLAGNAILSLLVLKERALHKAPYYF 60
Query: 61 LLDLCLADGIRSAVCFPFVLASVRHGSSWTFSALSCKIVAFMAVLFCFHAAFMLFCISVT 120
LLDLCLADGIRSAVCFPFVLASVRHGSSWTFSALSCKIVAFMAVLFCFHAAFMLFCISVT
Sbjct: 61 LLDLCLADGIRSAVCFPFVLASVRHGSSWTFSALSCKIVAFMAVLFCFHAAFMLFCISVT 120
Query: 121 RYMAIAHHRFYAKRMTLWTCAAVICMAWTLSVAMAFPPVFDVGTYKFIREEDQCIFEHRY 180
RYMAIAHHRFYAKRMTLWTCAAVICMAWTLSVAMAFPPVFDVGTYKFIREEDQCIFEHRY
Sbjct: 121 RYMAIAHHRFYAKRMTLWTCAAVICMAWTLSVAMAFPPVFDVGTYKFIREEDQCIFEHRY 180
Query: 181 FKANDTLGFMLMLAVLMAATHAVYGKLLLFEYRHRKMKPVQMVPAISQNWTFHGPGATGQ 240
FKANDTLGFMLMLAVLMAATHAVYGKLLLFEYRHRKMKPVQMVPAISQNWTFHGPGATGQ
Sbjct: 181 FKANDTLGFMLMLAVLMAATHAVYGKLLLFEYRHRKMKPVQMVPAISQNWTFHGPGATGQ 240
Query: 241 AAANWIAGFGRGPMPPTLLGIRQNGHAASRRLLGMDEVKGEKQLGRMFYAITLLFLLLWS 300
AAANWIAGFGRGPMPPTLLGIRQNGHAASRRLLGMDEVKGEKQLGRMFYAITLLFLLLWS
Sbjct: 241 AAANWIAGFGRGPMPPTLLGIRQNGHAASRRLLGMDEVKGEKQLGRMFYAITLLFLLLWS 300
Query: 301 PYIVACYWRVFVKACAVPHRYLATAVWMSFAQAAVNPIVCFLLNKDLKKCLRTHAPCWGT 360
PYIVACYWRVFVKACAVPHRYLATAVWMSFAQAAVNPIVCFLLNKDLKKCLRTHAPCWGT
Sbjct: 301 PYIVACYWRVFVKACAVPHRYLATAVWMSFAQAAVNPIVCFLLNKDLKKCLRTHAPCWGT 360
Query: 361 GGAPAPREPYCVM 373
GGAPAPREPYCVM
Sbjct: 361 GGAPAPREPYCVM 373
>gi|226342980 G protein-coupled receptor 85 [Homo sapiens]
Length = 370
Score = 496 bits (1278), Expect = e-140
Identities = 233/374 (62%), Positives = 289/374 (77%), Gaps = 5/374 (1%)
Query: 1 MANTTGEPEEVSGALSPPSASAYVKLVLLGLIMCVSLAGNAILSLLVLKERALHKAPYYF 60
MAN + + + LSP +A++KL LG I+ VS+ GN ++S+L++K++ LH+APYYF
Sbjct: 1 MANYSHAADNILQNLSP--LTAFLKLTSLGFIIGVSVVGNLLISILLVKDKTLHRAPYYF 58
Query: 61 LLDLCLADGIRSAVCFPFVLASVRHGSSWTFSALSCKIVAFMAVLFCFHAAFMLFCISVT 120
LLDLC +D +RSA+CFPFV SV++GS+WT+ L+CK++AF+ VL CFH AFMLFCISVT
Sbjct: 59 LLDLCCSDILRSAICFPFVFNSVKNGSTWTYGTLTCKVIAFLGVLSCFHTAFMLFCISVT 118
Query: 121 RYMAIAHHRFYAKRMTLWTCAAVICMAWTLSVAMAFPPVFDVGTYKFIREEDQCIFEHRY 180
RY+AIAHHRFY KR+T WTC AVICM WTLSVAMAFPPV DVGTY FIREEDQC F+HR
Sbjct: 119 RYLAIAHHRFYTKRLTFWTCLAVICMVWTLSVAMAFPPVLDVGTYSFIREEDQCTFQHRS 178
Query: 181 FKANDTLGFMLMLAVLMAATHAVYGKLLLFEYRHRKMKPVQMVPAISQNWTFHGPGATGQ 240
F+AND+LGFML+LA+++ AT VY KL+ F + RKMKPVQ V A+SQNWTFHGPGA+GQ
Sbjct: 179 FRANDSLGFMLLLALILLATQLVYLKLIFFVHDRRKMKPVQFVAAVSQNWTFHGPGASGQ 238
Query: 241 AAANWIAGFGRGPMPPTLLGIRQNGHAAS-RRLLGMDEVKGEKQLGRMFYAITLLFLLLW 299
AAANW+AGFGRGP PPTLLGIRQN + RRLL +DE K EK++ RMFY +T LFL LW
Sbjct: 239 AAANWLAGFGRGPTPPTLLGIRQNANTTGRRRLLVLDEFKMEKRISRMFYIMTFLFLTLW 298
Query: 300 SPYIVACYWRVFVKACAVPHRYLATAVWMSFAQAAVNPIVCFLLNKDLKKCLRTHAPCWG 359
PY+VACYWRVF + VP +L AVWMSFAQA +NP VC N++L++C T
Sbjct: 299 GPYLVACYWRVFARGPVVPGGFLTAAVWMSFAQAGINPFVCIFSNRELRRCFST--TLLY 356
Query: 360 TGGAPAPREPYCVM 373
+ PREPYCV+
Sbjct: 357 CRKSRLPREPYCVI 370
>gi|226342978 G protein-coupled receptor 85 [Homo sapiens]
Length = 370
Score = 496 bits (1278), Expect = e-140
Identities = 233/374 (62%), Positives = 289/374 (77%), Gaps = 5/374 (1%)
Query: 1 MANTTGEPEEVSGALSPPSASAYVKLVLLGLIMCVSLAGNAILSLLVLKERALHKAPYYF 60
MAN + + + LSP +A++KL LG I+ VS+ GN ++S+L++K++ LH+APYYF
Sbjct: 1 MANYSHAADNILQNLSP--LTAFLKLTSLGFIIGVSVVGNLLISILLVKDKTLHRAPYYF 58
Query: 61 LLDLCLADGIRSAVCFPFVLASVRHGSSWTFSALSCKIVAFMAVLFCFHAAFMLFCISVT 120
LLDLC +D +RSA+CFPFV SV++GS+WT+ L+CK++AF+ VL CFH AFMLFCISVT
Sbjct: 59 LLDLCCSDILRSAICFPFVFNSVKNGSTWTYGTLTCKVIAFLGVLSCFHTAFMLFCISVT 118
Query: 121 RYMAIAHHRFYAKRMTLWTCAAVICMAWTLSVAMAFPPVFDVGTYKFIREEDQCIFEHRY 180
RY+AIAHHRFY KR+T WTC AVICM WTLSVAMAFPPV DVGTY FIREEDQC F+HR
Sbjct: 119 RYLAIAHHRFYTKRLTFWTCLAVICMVWTLSVAMAFPPVLDVGTYSFIREEDQCTFQHRS 178
Query: 181 FKANDTLGFMLMLAVLMAATHAVYGKLLLFEYRHRKMKPVQMVPAISQNWTFHGPGATGQ 240
F+AND+LGFML+LA+++ AT VY KL+ F + RKMKPVQ V A+SQNWTFHGPGA+GQ
Sbjct: 179 FRANDSLGFMLLLALILLATQLVYLKLIFFVHDRRKMKPVQFVAAVSQNWTFHGPGASGQ 238
Query: 241 AAANWIAGFGRGPMPPTLLGIRQNGHAAS-RRLLGMDEVKGEKQLGRMFYAITLLFLLLW 299
AAANW+AGFGRGP PPTLLGIRQN + RRLL +DE K EK++ RMFY +T LFL LW
Sbjct: 239 AAANWLAGFGRGPTPPTLLGIRQNANTTGRRRLLVLDEFKMEKRISRMFYIMTFLFLTLW 298
Query: 300 SPYIVACYWRVFVKACAVPHRYLATAVWMSFAQAAVNPIVCFLLNKDLKKCLRTHAPCWG 359
PY+VACYWRVF + VP +L AVWMSFAQA +NP VC N++L++C T
Sbjct: 299 GPYLVACYWRVFARGPVVPGGFLTAAVWMSFAQAGINPFVCIFSNRELRRCFST--TLLY 356
Query: 360 TGGAPAPREPYCVM 373
+ PREPYCV+
Sbjct: 357 CRKSRLPREPYCVI 370
>gi|226342976 G protein-coupled receptor 85 [Homo sapiens]
Length = 370
Score = 496 bits (1278), Expect = e-140
Identities = 233/374 (62%), Positives = 289/374 (77%), Gaps = 5/374 (1%)
Query: 1 MANTTGEPEEVSGALSPPSASAYVKLVLLGLIMCVSLAGNAILSLLVLKERALHKAPYYF 60
MAN + + + LSP +A++KL LG I+ VS+ GN ++S+L++K++ LH+APYYF
Sbjct: 1 MANYSHAADNILQNLSP--LTAFLKLTSLGFIIGVSVVGNLLISILLVKDKTLHRAPYYF 58
Query: 61 LLDLCLADGIRSAVCFPFVLASVRHGSSWTFSALSCKIVAFMAVLFCFHAAFMLFCISVT 120
LLDLC +D +RSA+CFPFV SV++GS+WT+ L+CK++AF+ VL CFH AFMLFCISVT
Sbjct: 59 LLDLCCSDILRSAICFPFVFNSVKNGSTWTYGTLTCKVIAFLGVLSCFHTAFMLFCISVT 118
Query: 121 RYMAIAHHRFYAKRMTLWTCAAVICMAWTLSVAMAFPPVFDVGTYKFIREEDQCIFEHRY 180
RY+AIAHHRFY KR+T WTC AVICM WTLSVAMAFPPV DVGTY FIREEDQC F+HR
Sbjct: 119 RYLAIAHHRFYTKRLTFWTCLAVICMVWTLSVAMAFPPVLDVGTYSFIREEDQCTFQHRS 178
Query: 181 FKANDTLGFMLMLAVLMAATHAVYGKLLLFEYRHRKMKPVQMVPAISQNWTFHGPGATGQ 240
F+AND+LGFML+LA+++ AT VY KL+ F + RKMKPVQ V A+SQNWTFHGPGA+GQ
Sbjct: 179 FRANDSLGFMLLLALILLATQLVYLKLIFFVHDRRKMKPVQFVAAVSQNWTFHGPGASGQ 238
Query: 241 AAANWIAGFGRGPMPPTLLGIRQNGHAAS-RRLLGMDEVKGEKQLGRMFYAITLLFLLLW 299
AAANW+AGFGRGP PPTLLGIRQN + RRLL +DE K EK++ RMFY +T LFL LW
Sbjct: 239 AAANWLAGFGRGPTPPTLLGIRQNANTTGRRRLLVLDEFKMEKRISRMFYIMTFLFLTLW 298
Query: 300 SPYIVACYWRVFVKACAVPHRYLATAVWMSFAQAAVNPIVCFLLNKDLKKCLRTHAPCWG 359
PY+VACYWRVF + VP +L AVWMSFAQA +NP VC N++L++C T
Sbjct: 299 GPYLVACYWRVFARGPVVPGGFLTAAVWMSFAQAGINPFVCIFSNRELRRCFST--TLLY 356
Query: 360 TGGAPAPREPYCVM 373
+ PREPYCV+
Sbjct: 357 CRKSRLPREPYCVI 370
>gi|153266936 G protein-coupled receptor 85 [Homo sapiens]
Length = 370
Score = 496 bits (1278), Expect = e-140
Identities = 233/374 (62%), Positives = 289/374 (77%), Gaps = 5/374 (1%)
Query: 1 MANTTGEPEEVSGALSPPSASAYVKLVLLGLIMCVSLAGNAILSLLVLKERALHKAPYYF 60
MAN + + + LSP +A++KL LG I+ VS+ GN ++S+L++K++ LH+APYYF
Sbjct: 1 MANYSHAADNILQNLSP--LTAFLKLTSLGFIIGVSVVGNLLISILLVKDKTLHRAPYYF 58
Query: 61 LLDLCLADGIRSAVCFPFVLASVRHGSSWTFSALSCKIVAFMAVLFCFHAAFMLFCISVT 120
LLDLC +D +RSA+CFPFV SV++GS+WT+ L+CK++AF+ VL CFH AFMLFCISVT
Sbjct: 59 LLDLCCSDILRSAICFPFVFNSVKNGSTWTYGTLTCKVIAFLGVLSCFHTAFMLFCISVT 118
Query: 121 RYMAIAHHRFYAKRMTLWTCAAVICMAWTLSVAMAFPPVFDVGTYKFIREEDQCIFEHRY 180
RY+AIAHHRFY KR+T WTC AVICM WTLSVAMAFPPV DVGTY FIREEDQC F+HR
Sbjct: 119 RYLAIAHHRFYTKRLTFWTCLAVICMVWTLSVAMAFPPVLDVGTYSFIREEDQCTFQHRS 178
Query: 181 FKANDTLGFMLMLAVLMAATHAVYGKLLLFEYRHRKMKPVQMVPAISQNWTFHGPGATGQ 240
F+AND+LGFML+LA+++ AT VY KL+ F + RKMKPVQ V A+SQNWTFHGPGA+GQ
Sbjct: 179 FRANDSLGFMLLLALILLATQLVYLKLIFFVHDRRKMKPVQFVAAVSQNWTFHGPGASGQ 238
Query: 241 AAANWIAGFGRGPMPPTLLGIRQNGHAAS-RRLLGMDEVKGEKQLGRMFYAITLLFLLLW 299
AAANW+AGFGRGP PPTLLGIRQN + RRLL +DE K EK++ RMFY +T LFL LW
Sbjct: 239 AAANWLAGFGRGPTPPTLLGIRQNANTTGRRRLLVLDEFKMEKRISRMFYIMTFLFLTLW 298
Query: 300 SPYIVACYWRVFVKACAVPHRYLATAVWMSFAQAAVNPIVCFLLNKDLKKCLRTHAPCWG 359
PY+VACYWRVF + VP +L AVWMSFAQA +NP VC N++L++C T
Sbjct: 299 GPYLVACYWRVFARGPVVPGGFLTAAVWMSFAQAGINPFVCIFSNRELRRCFST--TLLY 356
Query: 360 TGGAPAPREPYCVM 373
+ PREPYCV+
Sbjct: 357 CRKSRLPREPYCVI 370
>gi|9506747 G protein-coupled receptor 27 [Homo sapiens]
Length = 375
Score = 399 bits (1026), Expect = e-111
Identities = 197/362 (54%), Positives = 259/362 (71%), Gaps = 12/362 (3%)
Query: 1 MANTTGEPEEVSGALSPPSASAYVKLVLLGLIMCVSLAGNAILSLLVLKERALHKAPYYF 60
MAN + E G+ +A+ +KL L L++CVSLAGN + +LL+++ER+LH+APYY
Sbjct: 1 MANAS----EPGGSGGGEAAALGLKLATLSLLLCVSLAGNVLFALLIVRERSLHRAPYYL 56
Query: 61 LLDLCLADGIRSAVCFPFVLASVRHGSSWTFS---ALSCKIVAFMAVLFCFHAAFMLFCI 117
LLDLCLADG+R+ C P V+ + R ++ + AL CK++AF+A LFCFHAAF+L +
Sbjct: 57 LLDLCLADGLRALACLPAVMLAARRAAAAAGAPPGALGCKLLAFLAALFCFHAAFLLLGV 116
Query: 118 SVTRYMAIAHHRFYAKRMTLWTCAAV-ICMAWTLSVAMAFPPVFDVGTYKFIREEDQCIF 176
VTRY+AIAHHRFYA+R+ W CAA+ +C AW L++A AFPPV D G E+ C
Sbjct: 117 GVTRYLAIAHHRFYAERLAGWPCAAMLVCAAWALALAAAFPPVLDGGGDD---EDAPCAL 173
Query: 177 EHRYFKANDTLGFMLMLAVLMAATHAVYGKLLLFEYRHRKMKPVQMVPAISQNWTFHGPG 236
E R A LGF+L+LAV++ ATH VY +LL F + RKM+P ++VPA+S +WTFHGPG
Sbjct: 174 EQRPDGAPGALGFLLLLAVVVGATHLVYLRLLFFIHDRRKMRPARLVPAVSHDWTFHGPG 233
Query: 237 ATGQAAANWIAGFGRGPMPPTLLGIRQNGHA-ASRRLLGMDEVKGEKQLGRMFYAITLLF 295
ATGQAAANW AGFGRGP PP L+GIR G +RRLL ++E K EK+L +MFYA+TLLF
Sbjct: 234 ATGQAAANWTAGFGRGPTPPALVGIRPAGPGRGARRLLVLEEFKTEKRLCKMFYAVTLLF 293
Query: 296 LLLWSPYIVACYWRVFVKACAVPHRYLATAVWMSFAQAAVNPIVCFLLNKDLKKCLRTHA 355
LLLW PY+VA Y RV V+ AVP YL +VW++FAQA +NP+VCFL N++L+ C R
Sbjct: 294 LLLWGPYVVASYLRVLVRPGAVPQAYLTASVWLTFAQAGINPVVCFLFNRELRDCFRAQF 353
Query: 356 PC 357
PC
Sbjct: 354 PC 355
>gi|89191861 dopamine receptor D3 isoform a [Homo sapiens]
Length = 400
Score = 89.4 bits (220), Expect = 5e-18
Identities = 88/397 (22%), Positives = 160/397 (40%), Gaps = 50/397 (12%)
Query: 3 NTTGEPEEVSGALSPPSASAYVKLVLLGLIMCVSLAGNAILSLLVLKERALHKAPYYFLL 62
N T E +GA S AY L LI+ + + GN ++ + VLKERAL Y ++
Sbjct: 12 NYTCGAENSTGA-SQARPHAYYALSYCALILAI-VFGNGLVCMAVLKERALQTTTNYLVV 69
Query: 63 DLCLADGIRSAVCFPFVLASVRHGSSWTFSALSCKIVAFMAVLFCFHAAFMLFCISVTRY 122
L +AD + + + P+V+ G W FS + C + + V+ C + L IS+ RY
Sbjct: 70 SLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRY 129
Query: 123 MAI---AHHRFYAKRMTLWTCAAVICMAWTLSVAMAFPPVFDVGTYKFIREEDQCIFEHR 179
A+ H++ + + A +I W L+ A++ P +F T + C +
Sbjct: 130 TAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNT---TGDPTVCSISNP 186
Query: 180 YFKA-NDTLGFMLMLAVLMAATHAVYGKLLLFEYRHRK------------MKP------- 219
F + + F L V + +Y ++ + R RK ++P
Sbjct: 187 DFVIYSSVVSFYLPFGVTVLVYARIY---VVLKQRRRKRILTRQNSQCNSVRPGFPQQTL 243
Query: 220 --------VQMVPAISQNWTFHGPGATGQAAANWIAGFGRGPMPPTL-----LGIRQ--N 264
++ +I Q+ GPG + R + PT+ L +R+ N
Sbjct: 244 SPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSN 303
Query: 265 GHAASRRLLGMDEVKG----EKQLGRMFYAITLLFLLLWSPYIVACYWRVFVKACAVPHR 320
G ++ LG + +G EK+ +M + F++ W P+ + + C V
Sbjct: 304 GRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPE 363
Query: 321 YLATAVWMSFAQAAVNPIVCFLLNKDLKKCLRTHAPC 357
+ W+ + +A+NP++ N + +K C
Sbjct: 364 LYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC 400
>gi|10835175 5-hydroxytryptamine (serotonin) receptor 2A [Homo
sapiens]
Length = 471
Score = 88.6 bits (218), Expect = 8e-18
Identities = 77/339 (22%), Positives = 141/339 (41%), Gaps = 28/339 (8%)
Query: 27 VLLGLIMCVSLAGNAILSLLVLKERALHKAPYYFLLDLCLADGIRSAVCFPFVLASVRHG 86
+L +++ +++AGN ++ + V E+ L A YFL+ L +AD + + P + ++ +G
Sbjct: 79 LLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYG 138
Query: 87 SSWTFSALSCKIVAFMAVLFCFHAAFMLFCISVTRYMAIA----HHRFYAKRMTLWTCAA 142
W + C + ++ VLF + L IS+ RY+AI H RF ++ A
Sbjct: 139 YRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIA 198
Query: 143 VICMAWTLSVAMAFP-PVFDVGTYKFIREEDQCIFEHRYFKANDTLGFMLMLAVLMAATH 201
V WT+SV ++ P PVF + + +E C+ F + + +M T+
Sbjct: 199 V----WTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITY 254
Query: 202 AVYGKLLLFEYRHRKMKPVQMVPAISQNWTFHGPGATGQAAANWIAGFGRGPMPPTLLGI 261
+ K L + + V + Q++ + F R
Sbjct: 255 FLTIKSL-------QKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIH------- 300
Query: 262 RQNGHAASRRLLGMDEVKGEKQLGRMFYAITLLFLLLWSPYIVACYWRVFVKACA---VP 318
R+ G RR M + E++ ++ + LF+++W P+ + V K V
Sbjct: 301 REPGSYTGRRT--MQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVI 358
Query: 319 HRYLATAVWMSFAQAAVNPIVCFLLNKDLKKCLRTHAPC 357
L VW+ + +AVNP+V L NK + + C
Sbjct: 359 GALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQC 397
>gi|28875799 cholecystokinin B receptor [Homo sapiens]
Length = 447
Score = 86.3 bits (212), Expect = 4e-17
Identities = 97/381 (25%), Positives = 155/381 (40%), Gaps = 30/381 (7%)
Query: 1 MANTTGEPEEVSGALSPPSASAYVKLVLLGLIMCVSLAGNAILSLLVLKERALHKAPYYF 60
+ N + EP + GA + A +++ L +I +S+ GN ++ +++ R L F
Sbjct: 34 VGNLSCEPPRIRGAGTRELELA-IRITLYAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAF 92
Query: 61 LLDLCLADGIRSAVCFPFVLASVRHGSSWTFSALSCKIVAFMAVLFCFHAAFMLFCISVT 120
LL L ++D + + C PF L G ++ F + CK V+++ + + L I++
Sbjct: 93 LLSLAVSDLLLAVACMPFTLLPNLMG-TFIFGTVICKAVSYLMGVSVSVSTLSLVAIALE 151
Query: 121 RYMAIAHHRFYAKRMTLWTCAAVICMAWTLSVAMAFP-PVFDVGTYKFIREEDQCIFEHR 179
RY AI T A VI W LS + P PV+ V QC+
Sbjct: 152 RYSAICRPLQARVWQTRSHAARVIVATWLLSGLLMVPYPVYTV-VQPVGPRVLQCVHRWP 210
Query: 180 YFKANDTLGFMLML------AVLMAATHAVYGKLLLFEYR----------HRKMKPVQMV 223
+ T +L+L V+MA + + + L R R +
Sbjct: 211 SARVRQTWSVLLLLLLFFIPGVVMAVAYGLISRELYLGLRFDGDSDSDSQSRVRNQGGLP 270
Query: 224 PAISQNWTFH-GPGATGQAAANWIAGFGRGPMPPTLLGIRQNGHAASRRLLGMDEVKGEK 282
A+ QN GA G+ + R L + G + R ++ +K
Sbjct: 271 GAVHQNGRCRPETGAVGEDSDGCYVQLPRSRPALELTALTAPGPGSGSRPT-QAKLLAKK 329
Query: 283 QLGRMFYAITLLFLLLWSPYIVACYWRVFVKACAVPHRYLATAV-----WMSFAQAAVNP 337
++ RM I +LF L W P A WR F A HR L+ A +S+A A VNP
Sbjct: 330 RVVRMLLVIVVLFFLCWLPVYSANTWRAFDGPGA--HRALSGAPISFIHLLSYASACVNP 387
Query: 338 IV-CFLLNKDLKKCLRTHAPC 357
+V CF+ + + CL T A C
Sbjct: 388 LVYCFMHRRFRQACLETCARC 408
>gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens]
Length = 432
Score = 84.7 bits (208), Expect = 1e-16
Identities = 75/358 (20%), Positives = 137/358 (38%), Gaps = 28/358 (7%)
Query: 8 PEEVSGALSPPSASAYVKLVL---LGLIMCVSLAGNAILSLLVLKERALHKAPYYFLLDL 64
P+ SG + K+V+ L LI +++AGN ++ + V + L + Y ++ L
Sbjct: 64 PDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSL 123
Query: 65 CLADGIRSAVCFPFVLASVRHGSSWTFSALSCKIVAFMAVLFCFHAAFMLFCISVTRYMA 124
LAD + PFV + G W F C + M V+ C + L IS+ RY+
Sbjct: 124 ALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLG 183
Query: 125 IAHHRFYAKRMTLWTCAAVICMAWTLSVAMAFPPVFDVGTYKFIREEDQCIF--EHRYFK 182
I Y R A +I W LS ++ PP+F G + + ++ C+ + Y
Sbjct: 184 ITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLF--GWAQNVNDDKVCLISQDFGYTI 241
Query: 183 ANDTLGFMLMLAVLMAATHAVYGKLLLFEYRHRKMKPVQMVPAISQNWTFHGPGATGQAA 242
+ + F + ++V++ + +Y +H+ PG
Sbjct: 242 YSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHK------------------FPGFPRVEP 283
Query: 243 ANWIAGFGRGPMPPTLLGIRQNGHAASRRLLGMDEVKGEKQLGRMFYAITLLFLLLWSPY 302
+ IA G + + + K E++ I F + W P+
Sbjct: 284 DSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPF 343
Query: 303 IVACYWRVFV---KACAVPHRYLATAVWMSFAQAAVNPIVCFLLNKDLKKCLRTHAPC 357
+ R F+ +P T +W+ +A + +NP + N+DL+ R+ C
Sbjct: 344 FLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQC 401
>gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens]
Length = 479
Score = 84.7 bits (208), Expect = 1e-16
Identities = 75/358 (20%), Positives = 137/358 (38%), Gaps = 28/358 (7%)
Query: 8 PEEVSGALSPPSASAYVKLVL---LGLIMCVSLAGNAILSLLVLKERALHKAPYYFLLDL 64
P+ SG + K+V+ L LI +++AGN ++ + V + L + Y ++ L
Sbjct: 64 PDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSL 123
Query: 65 CLADGIRSAVCFPFVLASVRHGSSWTFSALSCKIVAFMAVLFCFHAAFMLFCISVTRYMA 124
LAD + PFV + G W F C + M V+ C + L IS+ RY+
Sbjct: 124 ALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLG 183
Query: 125 IAHHRFYAKRMTLWTCAAVICMAWTLSVAMAFPPVFDVGTYKFIREEDQCIF--EHRYFK 182
I Y R A +I W LS ++ PP+F G + + ++ C+ + Y
Sbjct: 184 ITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLF--GWAQNVNDDKVCLISQDFGYTI 241
Query: 183 ANDTLGFMLMLAVLMAATHAVYGKLLLFEYRHRKMKPVQMVPAISQNWTFHGPGATGQAA 242
+ + F + ++V++ + +Y +H+ PG
Sbjct: 242 YSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHK------------------FPGFPRVEP 283
Query: 243 ANWIAGFGRGPMPPTLLGIRQNGHAASRRLLGMDEVKGEKQLGRMFYAITLLFLLLWSPY 302
+ IA G + + + K E++ I F + W P+
Sbjct: 284 DSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPF 343
Query: 303 IVACYWRVFV---KACAVPHRYLATAVWMSFAQAAVNPIVCFLLNKDLKKCLRTHAPC 357
+ R F+ +P T +W+ +A + +NP + N+DL+ R+ C
Sbjct: 344 FLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQC 401
>gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens]
Length = 445
Score = 84.7 bits (208), Expect = 1e-16
Identities = 75/358 (20%), Positives = 137/358 (38%), Gaps = 28/358 (7%)
Query: 8 PEEVSGALSPPSASAYVKLVL---LGLIMCVSLAGNAILSLLVLKERALHKAPYYFLLDL 64
P+ SG + K+V+ L LI +++AGN ++ + V + L + Y ++ L
Sbjct: 64 PDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSL 123
Query: 65 CLADGIRSAVCFPFVLASVRHGSSWTFSALSCKIVAFMAVLFCFHAAFMLFCISVTRYMA 124
LAD + PFV + G W F C + M V+ C + L IS+ RY+
Sbjct: 124 ALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLG 183
Query: 125 IAHHRFYAKRMTLWTCAAVICMAWTLSVAMAFPPVFDVGTYKFIREEDQCIF--EHRYFK 182
I Y R A +I W LS ++ PP+F G + + ++ C+ + Y
Sbjct: 184 ITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLF--GWAQNVNDDKVCLISQDFGYTI 241
Query: 183 ANDTLGFMLMLAVLMAATHAVYGKLLLFEYRHRKMKPVQMVPAISQNWTFHGPGATGQAA 242
+ + F + ++V++ + +Y +H+ PG
Sbjct: 242 YSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHK------------------FPGFPRVEP 283
Query: 243 ANWIAGFGRGPMPPTLLGIRQNGHAASRRLLGMDEVKGEKQLGRMFYAITLLFLLLWSPY 302
+ IA G + + + K E++ I F + W P+
Sbjct: 284 DSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPF 343
Query: 303 IVACYWRVFV---KACAVPHRYLATAVWMSFAQAAVNPIVCFLLNKDLKKCLRTHAPC 357
+ R F+ +P T +W+ +A + +NP + N+DL+ R+ C
Sbjct: 344 FLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQC 401
>gi|222080049 5-hydroxytryptamine (serotonin) receptor 2B [Homo
sapiens]
Length = 481
Score = 84.7 bits (208), Expect = 1e-16
Identities = 79/368 (21%), Positives = 143/368 (38%), Gaps = 20/368 (5%)
Query: 4 TTGEPEEVSGALSPPSASAYVKLVLLGLIMCVSLAGNAILSLLVLKERALHKAPYYFLLD 63
T PEE+ + + +L+ +++ ++ GN ++ L V E+ L A YFL+
Sbjct: 36 TESIPEEMKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMS 95
Query: 64 LCLADGIRSAVCFPFVLASVRHGSSWTFSALSCKIVAFMAVLFCFHAAFMLFCISVTRYM 123
L +AD + P L ++ + W + C F+ VLF + L ISV RY+
Sbjct: 96 LAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYI 155
Query: 124 AIAHHRFYAKRMTLWTCAAVICMAWTLSVAMAFP-PVFDVGTYKFIREEDQCIFEHRYFK 182
AI + + T I + W +S+ +A P P+ + T C+ F
Sbjct: 156 AIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFG 215
Query: 183 ANDTLGFM--------LMLAVLMAATHAVYGKLLLFEYRHRKMKPVQMVPAISQNWTF-- 232
G + +M+ HA+ K L K KP Q + ++ + F
Sbjct: 216 DFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLV-----KNKPPQRLTWLTVSTVFQR 270
Query: 233 -HGPGATGQAAANWIAGFGRGPMPPTLLGIRQNGHAASRRLLGMDEVKGEKQLGRMFYAI 291
P ++ + A + G + P ++ + + E++ ++ +
Sbjct: 271 DETPCSSPEKVA-MLDGSRKDKALPNSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIV 329
Query: 292 TLLFLLLWSPYIVACYWRVFVKAC--AVPHRYLATAVWMSFAQAAVNPIVCFLLNKDLKK 349
LFLL+W P+ + V +C L VW+ + + VNP+V L NK +
Sbjct: 330 FFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRD 389
Query: 350 CLRTHAPC 357
+ C
Sbjct: 390 AFGRYITC 397
>gi|4502607 cholecystokinin A receptor [Homo sapiens]
Length = 428
Score = 83.2 bits (204), Expect = 3e-16
Identities = 85/361 (23%), Positives = 139/361 (38%), Gaps = 23/361 (6%)
Query: 24 VKLVLLGLIMCVSLAGNAILSLLVLKERALHKAPYYFLLDLCLADGIRSAVCFPFVLASV 83
V+++L LI +S+ GN ++ ++++ + + FLL L ++D + C PF L
Sbjct: 43 VQILLYSLIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIP- 101
Query: 84 RHGSSWTFSALSCKIVAFMAVLFCFHAAFMLFCISVTRYMAIAHHRFYAKRMTLWTCAAV 143
+ F + CK + + F L IS+ RY AI T V
Sbjct: 102 NLLKDFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICKPLQSRVWQTKSHALKV 161
Query: 144 ICMAWTLSVAMAFPPVFDVGTYKFIREEDQCIFEHRYFKANDTL-----GFMLMLAVLM- 197
I W LS + P F + +Q R+ ND + F+L++ L+
Sbjct: 162 IAATWCLSFTIMTPYPIYSNLVPFTKNNNQTANMCRFLLPNDVMQQSWHTFLLLILFLIP 221
Query: 198 -AATHAVYGKLLLFEYRHRKMKPVQMVPAISQNWTFHGPGATGQAAANWIAG-FGRGPMP 255
YG + L Y+ K + Q A + P T G + + P
Sbjct: 222 GIVMMVAYGLISLELYQGIKFEASQKKSAKERK-----PSTTSSGKYEDSDGCYLQKTRP 276
Query: 256 PTLLGIRQNGHAASRRL------LGMDEVKGEKQLGRMFYAITLLFLLLWSPYIVACYWR 309
P L +RQ +S R + +K++ RM I +LF L W P A WR
Sbjct: 277 PRKLELRQLSTGSSSRANRIRSNSSAANLMAKKRVIRMLIVIVVLFFLCWMPIFSANAWR 336
Query: 310 VFVKACA---VPHRYLATAVWMSFAQAAVNPIVCFLLNKDLKKCLRTHAPCWGTGGAPAP 366
+ A A + ++ + +S+ + VNPI+ +NK + PC G P
Sbjct: 337 AYDTASAERRLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPPGA 396
Query: 367 R 367
R
Sbjct: 397 R 397
>gi|89191863 dopamine receptor D3 isoform e [Homo sapiens]
Length = 367
Score = 81.6 bits (200), Expect = 1e-15
Identities = 79/363 (21%), Positives = 146/363 (40%), Gaps = 15/363 (4%)
Query: 3 NTTGEPEEVSGALSPPSASAYVKLVLLGLIMCVSLAGNAILSLLVLKERALHKAPYYFLL 62
N T E +GA S AY L LI+ + + GN ++ + VLKERAL Y ++
Sbjct: 12 NYTCGAENSTGA-SQARPHAYYALSYCALILAI-VFGNGLVCMAVLKERALQTTTNYLVV 69
Query: 63 DLCLADGIRSAVCFPFVLASVRHGSSWTFSALSCKIVAFMAVLFCFHAAFMLFCISVTRY 122
L +AD + + + P+V+ G W FS + C + + V+ C + L IS+ RY
Sbjct: 70 SLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRY 129
Query: 123 MAI---AHHRFYAKRMTLWTCAAVICMAWTLSVAMAFPPVFDVGTYKFIREEDQCIFEHR 179
A+ H++ + + A +I W L+ A++ P +F T + C +
Sbjct: 130 TAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNT---TGDPTVCSISNP 186
Query: 180 YFKA-NDTLGFMLMLAVLMAATHAVYGKLLLFEYRHRKMKPVQMVPAISQNWTFHGPGAT 238
F + + F L V + +Y ++L + R +++ Q S F +
Sbjct: 187 DFVIYSSVVSFYLPFGVTVLVYARIY--VVLKQRRRKRILTRQNSQCNSVRPGFPQQTLS 244
Query: 239 GQAAANWIAGFGRGPMPPTL--LGIRQNGHAASRRLLGMDEVK--GEKQLGRMFYAITLL 294
A + + L G ++ G R + + EK+ +M +
Sbjct: 245 PDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLMPLREKKATQMVAIVLGA 304
Query: 295 FLLLWSPYIVACYWRVFVKACAVPHRYLATAVWMSFAQAAVNPIVCFLLNKDLKKCLRTH 354
F++ W P+ + + C V + W+ + +A+NP++ N + +K
Sbjct: 305 FIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKI 364
Query: 355 APC 357
C
Sbjct: 365 LSC 367
>gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo
sapiens]
Length = 366
Score = 80.5 bits (197), Expect = 2e-15
Identities = 72/348 (20%), Positives = 143/348 (41%), Gaps = 23/348 (6%)
Query: 24 VKLVLLGLIMCVSLAGNAILSLLVLKERALHKAPYYFLLDLCLADGIRSAVCFPFVLASV 83
V L L GL + + + +++ +++ R LH Y + L + D + + + PF + +
Sbjct: 26 VSLTLSGLALMTTTINSLVIAAIIVT-RKLHHPANYLICSLAVTDFLVAVLVMPFSIVYI 84
Query: 84 RHGSSWTFSALSCKIVAFMAVLFCFHAAFMLFCISVTRYMAIAHHRFYAKRMTLWTCAAV 143
SW + C I + + C + L I++ RY AI YA++ T +
Sbjct: 85 VR-ESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIM 143
Query: 144 ICMAWTLSVAMAFPPVFDVGTYKFIREEDQCIFEHRYFKAN--DTLG-FMLMLAVLMAAT 200
I + W +SV ++ PP+F ++ +D+CI +H + + T G F + LA+++
Sbjct: 144 ITIVWIISVFISMPPLF--WRHQGTSRDDECIIKHDHIVSTIYSTFGAFYIPLALILILY 201
Query: 201 HAVYGKLLLFEYRHRKMKPVQMVPAISQNWTFHGPGATGQAAANWI-------AGFGRGP 253
+ +Y + Y R+ + Q G +T + +++
Sbjct: 202 YKIY-RAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTKSVSTSYVLEKSLSDPSTDFDK 260
Query: 254 MPPTLLGIRQN-GHAAS---RRLLGMDEVKGEKQLGRMFYAITLLFLLLWSPYIVACYWR 309
+ T+ +R H S +++ G E K LG + A F++ W P+ V
Sbjct: 261 IHSTVRSLRSEFKHEKSWRRQKISGTRERKAATTLGLILGA----FVICWLPFFVKELVV 316
Query: 310 VFVKACAVPHRYLATAVWMSFAQAAVNPIVCFLLNKDLKKCLRTHAPC 357
C + W+ + + +NP++ + N+D KK + C
Sbjct: 317 NVCDKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVRC 364
>gi|4504541 5-hydroxytryptamine (serotonin) receptor 2C [Homo
sapiens]
Length = 458
Score = 79.3 bits (194), Expect = 5e-15
Identities = 70/344 (20%), Positives = 143/344 (41%), Gaps = 37/344 (10%)
Query: 31 LIMCVSLAGNAILSLLVLKERALHKAPYYFLLDLCLADGIRSAVCFPFVLASVRHGSSWT 90
+I+ +++ GN ++ + V E+ LH A YFL+ L +AD + + P L ++ + W
Sbjct: 62 IIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWP 121
Query: 91 FSALSCKIVAFMAVLFCFHAAFMLFCISVTRYMA----IAHHRFYAKRMTLWTCAAVICM 146
C + + VLF + L IS+ RY+A I H RF ++ + A V
Sbjct: 122 LPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIV--- 178
Query: 147 AWTLSVAMAFP-PVFDVGTYK--FIREEDQCIFEHRYFKANDTLGFMLMLAVLM----AA 199
W +S+ ++ P PV + + F+ + + + + F + L +++
Sbjct: 179 -WAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLT 237
Query: 200 THAVYGKLLLFEYRHRKMKP---VQMVPAISQNWTFHGPGATGQAAANWIAGFGRGPMPP 256
+ + + L+ + H + P + + +N A + +AN P
Sbjct: 238 IYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRN------TAEEENSAN----------PN 281
Query: 257 TLLGIRQNGHAASRRLLGMDEVKGEKQLGRMFYAITLLFLLLWSPYIVACYWRVFV-KAC 315
R+ R M + E++ ++ + +FL++W P+ + V K+C
Sbjct: 282 QDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSC 341
Query: 316 --AVPHRYLATAVWMSFAQAAVNPIVCFLLNKDLKKCLRTHAPC 357
+ + L VW+ + + +NP+V L NK ++ + C
Sbjct: 342 NQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRC 385
>gi|4557265 beta-1-adrenergic receptor [Homo sapiens]
Length = 477
Score = 77.0 bits (188), Expect = 3e-14
Identities = 83/372 (22%), Positives = 148/372 (39%), Gaps = 45/372 (12%)
Query: 8 PEEVSGALSPPSASAYVKL---------VLLGLIMCVSLAGNAILSLLVLKERALHKAPY 58
P +L PP++ + L +L+ LI+ + +AGN ++ + + K L
Sbjct: 35 PASPPASLLPPASESPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTN 94
Query: 59 YFLLDLCLADGIRSAVCFPFVLASVRHGSSWTFSALSCKIVAFMAVLFCFHAAFMLFC-I 117
F++ L AD + + PF V G W + + C++ + VL C A+ C I
Sbjct: 95 LFIMSLASADLVMGLLVVPFGATIVVWGR-WEYGSFFCELWTSVDVL-CVTASIETLCVI 152
Query: 118 SVTRYMAIAHHRFYAKRMTLWTCAAVICMAWTLSVAMAFPPVFDVGTYKFIREEDQC--- 174
++ RY+AI Y +T ++C W +S ++F P+ E +C
Sbjct: 153 ALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYND 212
Query: 175 ------IFEHRYFKANDTLGFMLMLAVLMAATHAVYGKLLLFEYRHRKMKPVQMVPAISQ 228
+ Y A+ + F + L ++ + L +F +++K + +
Sbjct: 213 PKCCDFVTNRAYAIASSVVSFYVPLCIM------AFVYLRVFREAQKQVKKIDS----CE 262
Query: 229 NWTFHGPGATGQAAANWIAGFGRGPMPP-----TLLGIRQNGHAASR---RLLGMDEVKG 280
GP + + + P PP NG A R RL+ + E K
Sbjct: 263 RRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAPLANGRAGKRRPSRLVALREQKA 322
Query: 281 EKQLGRMFYAITLLFLLLWSPYIVACYWRVFVKACAVPHRYLATAVWMSFAQAAVNPIVC 340
K LG I +F L W P+ +A + F + VP R W+ +A +A NPI+
Sbjct: 323 LKTLG----IIMGVFTLCWLPFFLANVVKAFHRE-LVPDRLFVFFNWLGYANSAFNPII- 376
Query: 341 FLLNKDLKKCLR 352
+ + D +K +
Sbjct: 377 YCRSPDFRKAFQ 388
>gi|4503907 galanin receptor 3 [Homo sapiens]
Length = 368
Score = 76.3 bits (186), Expect = 4e-14
Identities = 83/351 (23%), Positives = 135/351 (38%), Gaps = 62/351 (17%)
Query: 16 SPPSASAYVKLVLLGLIMCVSLAGNA-ILSLLVLKERALHKAPY----YFLLDLCLADGI 70
SP S A V+ LI + GN +L++L+ + + P F+L+L +AD
Sbjct: 11 SPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLC 70
Query: 71 RSAVCFPFVLASVRHGSSWTFSALSCKIVAFMAVLFCFHAAFMLFCISVTRYMAIAHHRF 130
C PF A++ +W F AL CK V + L + ++F L +SV RY+A+ H
Sbjct: 71 FILCCVPFQ-ATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLR 129
Query: 131 YAKRMTLWTCAAVICMAWTLSVAMAFPPVFDVGTYKFIREEDQCI--FEHRYFKANDTLG 188
T A + + W L+ + P + GT ++ E C+ +E +A D
Sbjct: 130 SRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALE-LCVPAWEDARRRALDVAT 188
Query: 189 FMLMLAVLMAATHAVYGKLLLFEYRHRKMKPVQMVPAISQNWTFHGPGATGQAAANWIAG 248
F + +A YG+ L F W GP G AAA
Sbjct: 189 FAAGYLLPVAVVSLAYGRTLRF------------------LWAAVGP--AGAAAAE---- 224
Query: 249 FGRGPMPPTLLGIRQNGHAASRRLLGMDEVKGEKQLGRMFYAITLLFLLLWSPY--IVAC 306
A RR G + GR A+ L+ L W P+ ++ C
Sbjct: 225 -------------------ARRRATG--------RAGRAMLAVAALYALCWGPHHALILC 257
Query: 307 YWRVFVKACAVPHRYLATAVWMSFAQAAVNPIVCFLLNKDLKKCLRTHAPC 357
+W + + +++A + +NP+V L ++ + R PC
Sbjct: 258 FWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPC 308
>gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens]
Length = 455
Score = 75.9 bits (185), Expect = 6e-14
Identities = 80/361 (22%), Positives = 144/361 (39%), Gaps = 32/361 (8%)
Query: 1 MANTTGEPEEVSGALSPPSASAYVKLVLLGLIM----CVSLAGNAILSLLVLKERALHKA 56
M +G + S PP+ K +LLG+I+ + GN ++ L V R LH
Sbjct: 1 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV 60
Query: 57 PYYFLLDLCLADGIRSAVCFPFVLASVRHGSSWTFSALSCKIVAFMAVLFCFHAAFMLFC 116
+Y++++L +AD + ++ PF G W F + C I A + VL C + L
Sbjct: 61 THYYIVNLAVADLLLTSTVLPFSAIFEVLGY-WAFGRVFCNIWAAVDVLCCTASIMGLCI 119
Query: 117 ISVTRYMAIAHHRFYAKRMTLWTCAAVICMAWTLSVAMAFPPVFDVGTYKFIREEDQCIF 176
IS+ RY+ +++ Y +T + W LS+ ++ P+F ++ ED+ I
Sbjct: 120 ISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFG---WRQPAPEDETIC 176
Query: 177 ----EHRYFKANDTLGFMLMLAVLMAATHAVYGKLLLFEYRHRKMKP-VQMVPAISQNWT 231
E Y + F L LA+++ VY ++ + R +K ++ + S+ T
Sbjct: 177 QINEEPGYVLFSALGSFYLPLAIILVMYCRVY---VVAKRESRGLKSGLKTDKSDSEQVT 233
Query: 232 FHGPGATGQAAANWIAGFGRGPMPPTLLGIRQNGHAASRRLLGMDEVKGEKQLGRMFYAI 291
A + +A + H + R L E K K LG +
Sbjct: 234 LRIHRKNAPAGGSGMA------------SAKTKTHFSVRLLKFSREKKAAKTLG----IV 277
Query: 292 TLLFLLLWSPYIVACYWRVFVKACAVPHRYLATAVWMSFAQAAVNPIVCFLLNKDLKKCL 351
F+L W P+ + F W+ + + +NPI+ +++ KK
Sbjct: 278 VGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Query: 352 R 352
+
Sbjct: 338 Q 338
>gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens]
Length = 466
Score = 75.9 bits (185), Expect = 6e-14
Identities = 80/361 (22%), Positives = 144/361 (39%), Gaps = 32/361 (8%)
Query: 1 MANTTGEPEEVSGALSPPSASAYVKLVLLGLIM----CVSLAGNAILSLLVLKERALHKA 56
M +G + S PP+ K +LLG+I+ + GN ++ L V R LH
Sbjct: 1 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV 60
Query: 57 PYYFLLDLCLADGIRSAVCFPFVLASVRHGSSWTFSALSCKIVAFMAVLFCFHAAFMLFC 116
+Y++++L +AD + ++ PF G W F + C I A + VL C + L
Sbjct: 61 THYYIVNLAVADLLLTSTVLPFSAIFEVLGY-WAFGRVFCNIWAAVDVLCCTASIMGLCI 119
Query: 117 ISVTRYMAIAHHRFYAKRMTLWTCAAVICMAWTLSVAMAFPPVFDVGTYKFIREEDQCIF 176
IS+ RY+ +++ Y +T + W LS+ ++ P+F ++ ED+ I
Sbjct: 120 ISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFG---WRQPAPEDETIC 176
Query: 177 ----EHRYFKANDTLGFMLMLAVLMAATHAVYGKLLLFEYRHRKMKP-VQMVPAISQNWT 231
E Y + F L LA+++ VY ++ + R +K ++ + S+ T
Sbjct: 177 QINEEPGYVLFSALGSFYLPLAIILVMYCRVY---VVAKRESRGLKSGLKTDKSDSEQVT 233
Query: 232 FHGPGATGQAAANWIAGFGRGPMPPTLLGIRQNGHAASRRLLGMDEVKGEKQLGRMFYAI 291
A + +A + H + R L E K K LG +
Sbjct: 234 LRIHRKNAPAGGSGMA------------SAKTKTHFSVRLLKFSREKKAAKTLG----IV 277
Query: 292 TLLFLLLWSPYIVACYWRVFVKACAVPHRYLATAVWMSFAQAAVNPIVCFLLNKDLKKCL 351
F+L W P+ + F W+ + + +NPI+ +++ KK
Sbjct: 278 VGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Query: 352 R 352
+
Sbjct: 338 Q 338
>gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens]
Length = 475
Score = 75.9 bits (185), Expect = 6e-14
Identities = 80/361 (22%), Positives = 144/361 (39%), Gaps = 32/361 (8%)
Query: 1 MANTTGEPEEVSGALSPPSASAYVKLVLLGLIM----CVSLAGNAILSLLVLKERALHKA 56
M +G + S PP+ K +LLG+I+ + GN ++ L V R LH
Sbjct: 1 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV 60
Query: 57 PYYFLLDLCLADGIRSAVCFPFVLASVRHGSSWTFSALSCKIVAFMAVLFCFHAAFMLFC 116
+Y++++L +AD + ++ PF G W F + C I A + VL C + L
Sbjct: 61 THYYIVNLAVADLLLTSTVLPFSAIFEVLGY-WAFGRVFCNIWAAVDVLCCTASIMGLCI 119
Query: 117 ISVTRYMAIAHHRFYAKRMTLWTCAAVICMAWTLSVAMAFPPVFDVGTYKFIREEDQCIF 176
IS+ RY+ +++ Y +T + W LS+ ++ P+F ++ ED+ I
Sbjct: 120 ISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFG---WRQPAPEDETIC 176
Query: 177 ----EHRYFKANDTLGFMLMLAVLMAATHAVYGKLLLFEYRHRKMKP-VQMVPAISQNWT 231
E Y + F L LA+++ VY ++ + R +K ++ + S+ T
Sbjct: 177 QINEEPGYVLFSALGSFYLPLAIILVMYCRVY---VVAKRESRGLKSGLKTDKSDSEQVT 233
Query: 232 FHGPGATGQAAANWIAGFGRGPMPPTLLGIRQNGHAASRRLLGMDEVKGEKQLGRMFYAI 291
A + +A + H + R L E K K LG +
Sbjct: 234 LRIHRKNAPAGGSGMA------------SAKTKTHFSVRLLKFSREKKAAKTLG----IV 277
Query: 292 TLLFLLLWSPYIVACYWRVFVKACAVPHRYLATAVWMSFAQAAVNPIVCFLLNKDLKKCL 351
F+L W P+ + F W+ + + +NPI+ +++ KK
Sbjct: 278 VGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Query: 352 R 352
+
Sbjct: 338 Q 338
>gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens]
Length = 429
Score = 75.9 bits (185), Expect = 6e-14
Identities = 80/361 (22%), Positives = 144/361 (39%), Gaps = 32/361 (8%)
Query: 1 MANTTGEPEEVSGALSPPSASAYVKLVLLGLIM----CVSLAGNAILSLLVLKERALHKA 56
M +G + S PP+ K +LLG+I+ + GN ++ L V R LH
Sbjct: 1 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV 60
Query: 57 PYYFLLDLCLADGIRSAVCFPFVLASVRHGSSWTFSALSCKIVAFMAVLFCFHAAFMLFC 116
+Y++++L +AD + ++ PF G W F + C I A + VL C + L
Sbjct: 61 THYYIVNLAVADLLLTSTVLPFSAIFEVLGY-WAFGRVFCNIWAAVDVLCCTASIMGLCI 119
Query: 117 ISVTRYMAIAHHRFYAKRMTLWTCAAVICMAWTLSVAMAFPPVFDVGTYKFIREEDQCIF 176
IS+ RY+ +++ Y +T + W LS+ ++ P+F ++ ED+ I
Sbjct: 120 ISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFG---WRQPAPEDETIC 176
Query: 177 ----EHRYFKANDTLGFMLMLAVLMAATHAVYGKLLLFEYRHRKMKP-VQMVPAISQNWT 231
E Y + F L LA+++ VY ++ + R +K ++ + S+ T
Sbjct: 177 QINEEPGYVLFSALGSFYLPLAIILVMYCRVY---VVAKRESRGLKSGLKTDKSDSEQVT 233
Query: 232 FHGPGATGQAAANWIAGFGRGPMPPTLLGIRQNGHAASRRLLGMDEVKGEKQLGRMFYAI 291
A + +A + H + R L E K K LG +
Sbjct: 234 LRIHRKNAPAGGSGMA------------SAKTKTHFSVRLLKFSREKKAAKTLG----IV 277
Query: 292 TLLFLLLWSPYIVACYWRVFVKACAVPHRYLATAVWMSFAQAAVNPIVCFLLNKDLKKCL 351
F+L W P+ + F W+ + + +NPI+ +++ KK
Sbjct: 278 VGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAF 337
Query: 352 R 352
+
Sbjct: 338 Q 338
>gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo
sapiens]
Length = 422
Score = 75.1 bits (183), Expect = 1e-13
Identities = 83/386 (21%), Positives = 150/386 (38%), Gaps = 64/386 (16%)
Query: 27 VLLGLIMCVSLAGNAILSLLVLKERALHKAPYYFLLDLCLADGIRSAVCFPFVLASVRHG 86
+LLG ++ ++ GNA + + ER+L Y + L + D + S + P A +
Sbjct: 41 LLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMA-ALYQVL 99
Query: 87 SSWTFSALSCKIVAFMAVLFCFHAAFMLFCISVTRYMAIAHHRFYAKRMTLWTCAAVICM 146
+ WT ++C + + VL C + L I++ RY AI Y + T AA+I +
Sbjct: 100 NKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISL 159
Query: 147 AWTLSVAMAFPPVFDVGTYKFIREEDQCIF--EHRYFKANDTLGFMLMLAVLMAATHAVY 204
W + ++ PP+ T + + D C +H Y + F + L +++ +Y
Sbjct: 160 TWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLML----VLY 215
Query: 205 GKLL-LFEYRHRK-MKPVQMVPAISQNWTFHGP----GATGQAAA-NWIAGF-------- 249
G++ +R RK +K V+ A +++ P G++ + NW G
Sbjct: 216 GRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGAL 275
Query: 250 ------------------------------------GRGPMPPTLLGIRQNGHAASRRLL 273
G P P + +A ++R +
Sbjct: 276 CANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKM 335
Query: 274 GM-DEVKGEKQLGRMFYAITLLFLLLWSP-YIVACYWRVFVKACAVPHRYLATAVWMSFA 331
+ E K K LG I F+L W P +IVA +C +P A W+ ++
Sbjct: 336 ALARERKTVKTLG----IIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYS 391
Query: 332 QAAVNPIVCFLLNKDLKKCLRTHAPC 357
+ +NP++ NKD + + C
Sbjct: 392 NSLLNPVIYAYFNKDFQNAFKKIIKC 417
>gi|5174595 melatonin receptor 1B [Homo sapiens]
Length = 362
Score = 75.1 bits (183), Expect = 1e-13
Identities = 59/207 (28%), Positives = 97/207 (46%), Gaps = 10/207 (4%)
Query: 17 PPSASAYVKLVLLGLIMCVSLAGNAILSLLVLKERALHKAPYYFLLDLCLADGIRSAVCF 76
PP + + VL+ + V + GN ++ L VL+ R L A FL+ L LAD + + +
Sbjct: 36 PPWVAPALSAVLI-VTTAVDVVGNLLVILSVLRNRKLRNAGNLFLVSLALADLVVAFYPY 94
Query: 77 PFVLASVRHGSSWTFSALSCKIVAFMAVLFCFHAAFMLFCISVTRYMAIAHHRFYAKRMT 136
P +L ++ + W CK AF+ L + F + I++ RY I H Y +
Sbjct: 95 PLILVAIFY-DGWALGEEHCKASAFVMGLSVIGSVFNITAIAINRYCYICHSMAYHRIYR 153
Query: 137 LWTCAAVICMAWTLSVAMAFPPVFDVGTYKFIREEDQCIF----EHRYFKANDTLGFMLM 192
W IC+ W L+V +A P F VG+ ++ C F +Y A + F+L
Sbjct: 154 RWHTPLHICLIWLLTV-VALLPNFFVGSLEYDPRIYSCTFIQTASTQYTAAVVVIHFLLP 212
Query: 193 LAVLMAATHAVYGKLLLFEYRHRKMKP 219
+AV+ ++ +L+ + R RK KP
Sbjct: 213 IAVVSFCYLRIW--VLVLQAR-RKAKP 236
>gi|194353970 alpha-2A-adrenergic receptor [Homo sapiens]
Length = 465
Score = 74.7 bits (182), Expect = 1e-13
Identities = 67/254 (26%), Positives = 109/254 (42%), Gaps = 13/254 (5%)
Query: 16 SPPSASAYVKLVLL-GLIMCVSLAGNAILSLLVLKERALHKAPYYFLLDLCLADGIRSAV 74
+P S + LV L GL+M +++ GN ++ + V RAL FL+ L AD + + +
Sbjct: 41 TPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATL 100
Query: 75 CFPFVLASVRHGSSWTFSALSCKIVAFMAVLFCFHAAFMLFCISVTRYMAIAHHRFYAKR 134
PF LA+ G W F C+I + VLFC + L IS+ RY +I Y +
Sbjct: 101 VIPFSLANEVMGY-WYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLK 159
Query: 135 MTLWTCAAVICMAWTLSVAMAFPPVFDV----GTYKFIREEDQC-IFEHRYFKANDTLGF 189
T A+I W +S ++FPP+ + G E +C I + +++ + +G
Sbjct: 160 RTPRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQPAEPRCEINDQKWYVISSCIGS 219
Query: 190 MLMLAVLMAATHAVYGKLLLFEYRHRKMKPVQMVP---AISQNWTFHGPGATGQAAANWI 246
++M VY ++ R ++ P + P A T P G +
Sbjct: 220 FFAPCLIMI---LVYVRIYQIAKRRTRVPPSRRGPDAVAAPPGGTERRPNGLGPERSAGP 276
Query: 247 AGFGRGPMPPTLLG 260
G P+P L G
Sbjct: 277 GGAEAEPLPTQLNG 290
Score = 38.5 bits (88), Expect = 0.010
Identities = 31/140 (22%), Positives = 56/140 (40%), Gaps = 23/140 (16%)
Query: 213 RHRKMKPVQMVPAISQNWTFHGPGATGQAAANWIAGFGRGPMPPTLLGIRQNGHAASRRL 272
R ++KP +P GPGATG I GP G + G A + R
Sbjct: 337 RASQVKPGDSLPR-------RGPGATG------IGTPAAGP------GEERVGAAKASRW 377
Query: 273 LGMDEVKGEKQLGRMFYAITLLFLLLWSPYIVACYWRVFVKACAVPHRYLATAVWMSFAQ 332
G EK+ + + +F++ W P+ + + C+VP W +
Sbjct: 378 RGRQN--REKRFTFVLAVVIGVFVVCWFPFFFT--YTLTAVGCSVPRTLFKFFFWFGYCN 433
Query: 333 AAVNPIVCFLLNKDLKKCLR 352
+++NP++ + N D ++ +
Sbjct: 434 SSLNPVIYTIFNHDFRRAFK 453
>gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo
sapiens]
Length = 390
Score = 73.9 bits (180), Expect = 2e-13
Identities = 75/336 (22%), Positives = 138/336 (41%), Gaps = 22/336 (6%)
Query: 26 LVLLGLIMCVSLAGNAILSLLVLKERALHKAPYYFLLDLCLADGIRSAVCFPFVLASVRH 85
++LL LI + NA + V + R LH Y + L + D + S + P
Sbjct: 53 VMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVT 112
Query: 86 GSSWTFSALSCKIVAFMAVLFCFHAAFMLFCISVTRYMAIAHHRFYAKRMTLWTCAAVIC 145
G WT + C + C + L I++ RY AI Y+ + T A +I
Sbjct: 113 GR-WTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIA 171
Query: 146 MAWTLSVAMAFPPVFDVGTYKFIREEDQCIF--EHRYFKANDTLGFMLMLAVLMAATHAV 203
+ W S++++ PP F K E +C+ +H + T+G +L+ A +
Sbjct: 172 LVWVFSISISLPPFF-WRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIA---L 227
Query: 204 YGKLLLFEYRHRKMK--PVQMVPAISQNWTF-HGPGATGQAAA-----NWIAGFGRGPMP 255
YG++ + E R R +K P + +++ PG+T + + P+
Sbjct: 228 YGRIYV-EARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGSPVY 286
Query: 256 PTLLGIR-QNGHAASRRLLGMDEVKGEKQLGRMFYAITLLFLLLWSPY-IVACYWRVFVK 313
+ +R + ++L+ E K K LG + A F++ W P+ I++ +
Sbjct: 287 VNQVKVRVSDALLEKKKLMAARERKATKTLGIILGA----FIVCWLPFFIISLVMPICKD 342
Query: 314 ACAVPHRYLATAVWMSFAQAAVNPIVCFLLNKDLKK 349
AC W+ + + +NPI+ + N+D K+
Sbjct: 343 ACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQ 378
>gi|71773208 alpha-2C-adrenergic receptor [Homo sapiens]
Length = 462
Score = 73.6 bits (179), Expect = 3e-13
Identities = 70/283 (24%), Positives = 118/283 (41%), Gaps = 20/283 (7%)
Query: 3 NTTGEPEEVSGALS--------PP----SASAYVKLV-LLGLIMCVSLAGNAILSLLVLK 49
N +G E SG ++ PP SA A L ++G ++ ++ GN ++ + VL
Sbjct: 19 NASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLT 78
Query: 50 ERALHKAPYYFLLDLCLADGIRSAVCFPFVLASVRHGSSWTFSALSCKIVAFMAVLFCFH 109
RAL FL+ L AD + + + PF LA+ + W F + C + + VLFC
Sbjct: 79 SRALRAPQNLFLVSLASADILVATLVMPFSLANELM-AYWYFGQVWCGVYLALDVLFCTS 137
Query: 110 AAFMLFCISVTRYMAIAHHRFYAKRMTLWTCAAVICMAWTLSVAMAFPPVFDVGTYKFIR 169
+ L IS+ RY ++ Y + T A I W +S ++FPP+ +
Sbjct: 138 SIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSLYRQPDGA 197
Query: 170 EEDQC-IFEHRYFKANDTLGFMLMLAVLMAATHAVYGKLLLFEYRHRKMKPVQMVPAISQ 228
QC + + ++ + +G ++M +A ++ R K + P +
Sbjct: 198 AYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRAPVGPDGAS 257
Query: 229 NWTFHGPGATGQAAANWIAGFGRGPMPPTLLGIRQNGHAASRR 271
T +G GA A N G PP + ++ AA RR
Sbjct: 258 PTTENGLGAAAGAGEN-----GHCAPPPADVEPDESSAAAERR 295
Score = 36.2 bits (82), Expect = 0.049
Identities = 15/73 (20%), Positives = 37/73 (50%), Gaps = 1/73 (1%)
Query: 281 EKQLGRMFYAITLLFLLLWSPYIVA-CYWRVFVKACAVPHRYLATAVWMSFAQAAVNPIV 339
EK+ + + +F+L W P+ + + + +AC VP W+ + +++NP++
Sbjct: 377 EKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFKFFFWIGYCNSSLNPVI 436
Query: 340 CFLLNKDLKKCLR 352
+ N+D ++ +
Sbjct: 437 YTVFNQDFRRSFK 449
>gi|13236497 5-hydroxytryptamine receptor 5A [Homo sapiens]
Length = 357
Score = 73.6 bits (179), Expect = 3e-13
Identities = 70/331 (21%), Positives = 129/331 (38%), Gaps = 28/331 (8%)
Query: 26 LVLLGLIMCVSLAGNAILSLLVLKERALHKAPYYFLLDLCLADGIRSAVCFPFVLASVRH 85
L LLG ++ + A N ++ +L+ R H+ P+ + + ++D + +A+ P L
Sbjct: 44 LTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELS 103
Query: 86 GSSWTFSALSCKIVAFMAVLFCFHAAFMLFCISVTRYMAIAHHRFYAKRMTLWTCAAVIC 145
G W C++ VL C + + + I++ RY +I H Y R +I
Sbjct: 104 GRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSNVMIA 163
Query: 146 MAWTLSVAMAFPP-VFDVG-TYKFIREEDQCIFEHRYFKANDTLGFMLMLAVLMAATHAV 203
+ W LS ++ P +F G TY EE Q E Y + F L L V++ +
Sbjct: 164 LTWALSAVISLAPLLFGWGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKI 223
Query: 204 YGKLLLFEYRHRKMKPVQMVPAISQNWTFHGPGATGQAAANWIAGFGRGPMPPTLLGIRQ 263
Y K F RK V + + + P + +R
Sbjct: 224 Y-KAAKFRVGSRKTNSVSPI-------------------SEAVEVKDSAKQPQMVFTVR- 262
Query: 264 NGHAASRRLLGMDEVKGEK-QLGRMFYAITL-LFLLLWSPYIVACYWRVFVKACAVPHRY 321
HA D + +K Q + I + +F+L W P+ + +C +P +
Sbjct: 263 --HATVTFQPEGDTWREQKEQRAALMVGILIGVFVLCWIPFFLTELISPLC-SCDIPAIW 319
Query: 322 LATAVWMSFAQAAVNPIVCFLLNKDLKKCLR 352
+ +W+ ++ + NP++ NK+ +
Sbjct: 320 KSIFLWLGYSNSFFNPLIYTAFNKNYNSAFK 350
>gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo
sapiens]
Length = 377
Score = 73.6 bits (179), Expect = 3e-13
Identities = 82/371 (22%), Positives = 153/371 (41%), Gaps = 30/371 (8%)
Query: 2 ANTTGEPEEVSGALSPPSASAY-VKL-VLLGLIMCVSLAGNAILSLLVLKERALHKAPYY 59
+N + E S A P + A + L V+L +I ++ NA + +L R LH Y
Sbjct: 16 SNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANY 75
Query: 60 FLLDLCLADGIRSAVCFPFVLA-SVRHGSSWTFSALSCKIVAFMAVLFCFHAAFMLFCIS 118
+ L D + S + P +A ++ H +W F + C I + C + L I+
Sbjct: 76 LIGSLATTDLLVSILVMPISIAYTITH--TWNFGQILCDIWLSSDITCCTASILHLCVIA 133
Query: 119 VTRYMAIAHHRFYAKRMTLWTCAAVICMAWTLSVAMAFPPVFDVGTYKFIREEDQCIFEH 178
+ RY AI Y+KR T A +I + W +S+ ++ PP+F K E C+
Sbjct: 134 LDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLF-WRQAKAQEEMSDCLVNT 192
Query: 179 RY--FKANDTLGFMLMLAVLMAATHAVYGKLLLFEYRHRKMKPVQMVPAISQNWTFHG-- 234
+ T G + +VL+ +YG++ YR + + + + +T
Sbjct: 193 SQISYTIYSTCGAFYIPSVLLI---ILYGRI----YRAARNRILNPPSLYGKRFTTAHLI 245
Query: 235 PGATGQAAANWIAGFGRG-------PMPPTLLGIRQNGHAASR-RLLGMDEVKGEKQLGR 286
G+ G + + + G P+ + I+ A R R+ E K K LG
Sbjct: 246 TGSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKATKILGI 305
Query: 287 MFYAITLLFLLLWSP-YIVACYWRVFVKACAVPHRYLATAVWMSFAQAAVNPIVCFLLNK 345
+ A F++ W P ++V+ + +C + W+ + + +NPI+ + N+
Sbjct: 306 ILGA----FIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNE 361
Query: 346 DLKKCLRTHAP 356
+ ++ + P
Sbjct: 362 EFRQAFQKIVP 372
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.330 0.139 0.461
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,012,573
Number of Sequences: 37866
Number of extensions: 616253
Number of successful extensions: 3183
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 464
Number of HSP's successfully gapped in prelim test: 264
Number of HSP's that attempted gapping in prelim test: 1872
Number of HSP's gapped (non-prelim): 1126
length of query: 373
length of database: 18,247,518
effective HSP length: 104
effective length of query: 269
effective length of database: 14,309,454
effective search space: 3849243126
effective search space used: 3849243126
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.