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Search of human proteins with 94721336
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|94721336 RUN and FYVE domain-containing 1 isoform a [Homo
sapiens]
(708 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|94721336 RUN and FYVE domain-containing 1 isoform a [Homo sap... 1395 0.0
gi|94721330 RUN and FYVE domain-containing 1 isoform b [Homo sap... 1178 0.0
gi|94721332 RUN and FYVE domain-containing 1 isoform b [Homo sap... 1178 0.0
gi|109240556 RUN and FYVE domain-containing 2 isoform a [Homo sa... 753 0.0
gi|82697315 RUN and FYVE domain containing 3 isoform 1 [Homo sap... 556 e-158
gi|195220720 RUN and FYVE domain containing 3 isoform 3 [Homo sa... 471 e-133
gi|7662352 RUN and FYVE domain containing 3 isoform 2 [Homo sapi... 463 e-130
gi|109240552 RUN and FYVE domain-containing 2 isoform b [Homo sa... 436 e-122
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 127 4e-29
gi|157738667 FYVE and coiled-coil domain containing 1 [Homo sapi... 117 5e-26
gi|197304746 RUN domain containing 3B isoform c [Homo sapiens] 114 2e-25
gi|197304744 RUN domain containing 3B isoform b [Homo sapiens] 113 5e-25
gi|221307580 RUN domain containing 3A isoform 3 [Homo sapiens] 108 2e-23
gi|19923090 RUN domain containing 3B isoform a [Homo sapiens] 103 4e-22
gi|221307578 RUN domain containing 3A isoform 1 [Homo sapiens] 103 5e-22
gi|5730015 RUN domain containing 3A isoform 2 [Homo sapiens] 103 5e-22
gi|58530840 desmoplakin isoform I [Homo sapiens] 92 2e-18
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 92 2e-18
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 92 2e-18
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 88 3e-17
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 88 3e-17
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 88 3e-17
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 88 3e-17
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 88 3e-17
gi|46593000 GRIP1 associated protein 1 isoform 2 [Homo sapiens] 87 4e-17
gi|156104908 myosin heavy chain 6 [Homo sapiens] 87 7e-17
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 86 9e-17
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 86 2e-16
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 85 3e-16
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 84 3e-16
>gi|94721336 RUN and FYVE domain-containing 1 isoform a [Homo
sapiens]
Length = 708
Score = 1395 bits (3610), Expect = 0.0
Identities = 708/708 (100%), Positives = 708/708 (100%)
Query: 1 MADREGGCAAGRGRELEPELEPGPGPGSALEPGEEFEIVDRSQLPGPGDLRSATRPRAAE 60
MADREGGCAAGRGRELEPELEPGPGPGSALEPGEEFEIVDRSQLPGPGDLRSATRPRAAE
Sbjct: 1 MADREGGCAAGRGRELEPELEPGPGPGSALEPGEEFEIVDRSQLPGPGDLRSATRPRAAE 60
Query: 61 GWSAPILTLARRATGNLSASCGSALRAAAGLGGGDSGDGTARAASKCQMMEERANLMHMM 120
GWSAPILTLARRATGNLSASCGSALRAAAGLGGGDSGDGTARAASKCQMMEERANLMHMM
Sbjct: 61 GWSAPILTLARRATGNLSASCGSALRAAAGLGGGDSGDGTARAASKCQMMEERANLMHMM 120
Query: 121 KLSIKVLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHGLKVKKSFIGQNKSFFGPLELV 180
KLSIKVLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHGLKVKKSFIGQNKSFFGPLELV
Sbjct: 121 KLSIKVLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHGLKVKKSFIGQNKSFFGPLELV 180
Query: 181 EKLCPEASDIATSVRNLPELKTAVGRGRAWLYLALMQKKLADYLKVLIDNKHLLSEFYEP 240
EKLCPEASDIATSVRNLPELKTAVGRGRAWLYLALMQKKLADYLKVLIDNKHLLSEFYEP
Sbjct: 181 EKLCPEASDIATSVRNLPELKTAVGRGRAWLYLALMQKKLADYLKVLIDNKHLLSEFYEP 240
Query: 241 EALMMEEEGMVIVGLLVGLNVLDANLCLKGEDLDSQVGVIDFSLYLKDVQDLDGGKEHER 300
EALMMEEEGMVIVGLLVGLNVLDANLCLKGEDLDSQVGVIDFSLYLKDVQDLDGGKEHER
Sbjct: 241 EALMMEEEGMVIVGLLVGLNVLDANLCLKGEDLDSQVGVIDFSLYLKDVQDLDGGKEHER 300
Query: 301 ITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQL 360
ITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQL
Sbjct: 301 ITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQL 360
Query: 361 REQNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLKEEKKVRLELEKE 420
REQNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLKEEKKVRLELEKE
Sbjct: 361 REQNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLKEEKKVRLELEKE 420
Query: 421 LELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQK 480
LELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQK
Sbjct: 421 LELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQK 480
Query: 481 NEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGGRIGALQLQLSQL 540
NEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGGRIGALQLQLSQL
Sbjct: 481 NEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGGRIGALQLQLSQL 540
Query: 541 HEQCSSLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKELRELQDEKAELQ 600
HEQCSSLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKELRELQDEKAELQ
Sbjct: 541 HEQCSSLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKELRELQDEKAELQ 600
Query: 601 KICEEQEQALQEMGLHLSQSKLKMEDIKEVNQALKGHAWLKDDEATHCRQCEKEFSISRR 660
KICEEQEQALQEMGLHLSQSKLKMEDIKEVNQALKGHAWLKDDEATHCRQCEKEFSISRR
Sbjct: 601 KICEEQEQALQEMGLHLSQSKLKMEDIKEVNQALKGHAWLKDDEATHCRQCEKEFSISRR 660
Query: 661 KHHCRNCGHIFCNTCSSNELALPSYPKPVRVCDSCHTLLLQRCSSTAS 708
KHHCRNCGHIFCNTCSSNELALPSYPKPVRVCDSCHTLLLQRCSSTAS
Sbjct: 661 KHHCRNCGHIFCNTCSSNELALPSYPKPVRVCDSCHTLLLQRCSSTAS 708
>gi|94721330 RUN and FYVE domain-containing 1 isoform b [Homo
sapiens]
Length = 600
Score = 1178 bits (3048), Expect = 0.0
Identities = 600/600 (100%), Positives = 600/600 (100%)
Query: 109 MMEERANLMHMMKLSIKVLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHGLKVKKSFIG 168
MMEERANLMHMMKLSIKVLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHGLKVKKSFIG
Sbjct: 1 MMEERANLMHMMKLSIKVLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHGLKVKKSFIG 60
Query: 169 QNKSFFGPLELVEKLCPEASDIATSVRNLPELKTAVGRGRAWLYLALMQKKLADYLKVLI 228
QNKSFFGPLELVEKLCPEASDIATSVRNLPELKTAVGRGRAWLYLALMQKKLADYLKVLI
Sbjct: 61 QNKSFFGPLELVEKLCPEASDIATSVRNLPELKTAVGRGRAWLYLALMQKKLADYLKVLI 120
Query: 229 DNKHLLSEFYEPEALMMEEEGMVIVGLLVGLNVLDANLCLKGEDLDSQVGVIDFSLYLKD 288
DNKHLLSEFYEPEALMMEEEGMVIVGLLVGLNVLDANLCLKGEDLDSQVGVIDFSLYLKD
Sbjct: 121 DNKHLLSEFYEPEALMMEEEGMVIVGLLVGLNVLDANLCLKGEDLDSQVGVIDFSLYLKD 180
Query: 289 VQDLDGGKEHERITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATD 348
VQDLDGGKEHERITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATD
Sbjct: 181 VQDLDGGKEHERITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATD 240
Query: 349 RICSLQEEQQQLREQNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLK 408
RICSLQEEQQQLREQNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLK
Sbjct: 241 RICSLQEEQQQLREQNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLK 300
Query: 409 EEKKVRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFH 468
EEKKVRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFH
Sbjct: 301 EEKKVRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFH 360
Query: 469 KAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGG 528
KAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGG
Sbjct: 361 KAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGG 420
Query: 529 RIGALQLQLSQLHEQCSSLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKE 588
RIGALQLQLSQLHEQCSSLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKE
Sbjct: 421 RIGALQLQLSQLHEQCSSLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKE 480
Query: 589 LRELQDEKAELQKICEEQEQALQEMGLHLSQSKLKMEDIKEVNQALKGHAWLKDDEATHC 648
LRELQDEKAELQKICEEQEQALQEMGLHLSQSKLKMEDIKEVNQALKGHAWLKDDEATHC
Sbjct: 481 LRELQDEKAELQKICEEQEQALQEMGLHLSQSKLKMEDIKEVNQALKGHAWLKDDEATHC 540
Query: 649 RQCEKEFSISRRKHHCRNCGHIFCNTCSSNELALPSYPKPVRVCDSCHTLLLQRCSSTAS 708
RQCEKEFSISRRKHHCRNCGHIFCNTCSSNELALPSYPKPVRVCDSCHTLLLQRCSSTAS
Sbjct: 541 RQCEKEFSISRRKHHCRNCGHIFCNTCSSNELALPSYPKPVRVCDSCHTLLLQRCSSTAS 600
>gi|94721332 RUN and FYVE domain-containing 1 isoform b [Homo
sapiens]
Length = 600
Score = 1178 bits (3048), Expect = 0.0
Identities = 600/600 (100%), Positives = 600/600 (100%)
Query: 109 MMEERANLMHMMKLSIKVLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHGLKVKKSFIG 168
MMEERANLMHMMKLSIKVLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHGLKVKKSFIG
Sbjct: 1 MMEERANLMHMMKLSIKVLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHGLKVKKSFIG 60
Query: 169 QNKSFFGPLELVEKLCPEASDIATSVRNLPELKTAVGRGRAWLYLALMQKKLADYLKVLI 228
QNKSFFGPLELVEKLCPEASDIATSVRNLPELKTAVGRGRAWLYLALMQKKLADYLKVLI
Sbjct: 61 QNKSFFGPLELVEKLCPEASDIATSVRNLPELKTAVGRGRAWLYLALMQKKLADYLKVLI 120
Query: 229 DNKHLLSEFYEPEALMMEEEGMVIVGLLVGLNVLDANLCLKGEDLDSQVGVIDFSLYLKD 288
DNKHLLSEFYEPEALMMEEEGMVIVGLLVGLNVLDANLCLKGEDLDSQVGVIDFSLYLKD
Sbjct: 121 DNKHLLSEFYEPEALMMEEEGMVIVGLLVGLNVLDANLCLKGEDLDSQVGVIDFSLYLKD 180
Query: 289 VQDLDGGKEHERITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATD 348
VQDLDGGKEHERITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATD
Sbjct: 181 VQDLDGGKEHERITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATD 240
Query: 349 RICSLQEEQQQLREQNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLK 408
RICSLQEEQQQLREQNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLK
Sbjct: 241 RICSLQEEQQQLREQNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLK 300
Query: 409 EEKKVRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFH 468
EEKKVRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFH
Sbjct: 301 EEKKVRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFH 360
Query: 469 KAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGG 528
KAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGG
Sbjct: 361 KAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGG 420
Query: 529 RIGALQLQLSQLHEQCSSLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKE 588
RIGALQLQLSQLHEQCSSLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKE
Sbjct: 421 RIGALQLQLSQLHEQCSSLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKE 480
Query: 589 LRELQDEKAELQKICEEQEQALQEMGLHLSQSKLKMEDIKEVNQALKGHAWLKDDEATHC 648
LRELQDEKAELQKICEEQEQALQEMGLHLSQSKLKMEDIKEVNQALKGHAWLKDDEATHC
Sbjct: 481 LRELQDEKAELQKICEEQEQALQEMGLHLSQSKLKMEDIKEVNQALKGHAWLKDDEATHC 540
Query: 649 RQCEKEFSISRRKHHCRNCGHIFCNTCSSNELALPSYPKPVRVCDSCHTLLLQRCSSTAS 708
RQCEKEFSISRRKHHCRNCGHIFCNTCSSNELALPSYPKPVRVCDSCHTLLLQRCSSTAS
Sbjct: 541 RQCEKEFSISRRKHHCRNCGHIFCNTCSSNELALPSYPKPVRVCDSCHTLLLQRCSSTAS 600
>gi|109240556 RUN and FYVE domain-containing 2 isoform a [Homo
sapiens]
Length = 641
Score = 753 bits (1945), Expect = 0.0
Identities = 381/614 (62%), Positives = 478/614 (77%), Gaps = 1/614 (0%)
Query: 93 GGDSGDGTARA-ASKCQMMEERANLMHMMKLSIKVLLQSALSLGRSLDADHAPLQQFFVV 151
GG G T R+ A+K ERANL++M KLSIK L++SALS GR+LD+D+ PLQQFFVV
Sbjct: 25 GGRRGMLTRRSLATKDPTAVERANLLNMAKLSIKGLIESALSFGRTLDSDYPPLQQFFVV 84
Query: 152 MEHCLKHGLKVKKSFIGQNKSFFGPLELVEKLCPEASDIATSVRNLPELKTAVGRGRAWL 211
MEHCLKHGLKV+KSF+ NK+ +GPLELVEKL PEA +I SVR+LP LKT +GR RAWL
Sbjct: 85 MEHCLKHGLKVRKSFLSYNKTIWGPLELVEKLYPEAEEIGASVRDLPGLKTPLGRARAWL 144
Query: 212 YLALMQKKLADYLKVLIDNKHLLSEFYEPEALMMEEEGMVIVGLLVGLNVLDANLCLKGE 271
LALMQKK+ADYL+ LI + LLSEFYE ALMMEEEG VIVGLLVGLNV+DANLC+KGE
Sbjct: 145 RLALMQKKMADYLRCLIIQRDLLSEFYEYHALMMEEEGAVIVGLLVGLNVIDANLCVKGE 204
Query: 272 DLDSQVGVIDFSLYLKDVQDLDGGKEHERITDVLDQKNYVEELNRHLSCTVGDLQTKIDG 331
DLDSQVGVIDFS+YLK+ +D+ + + +I +LDQKNYVEELNR L+ TV L +++D
Sbjct: 205 DLDSQVGVIDFSMYLKNEEDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDS 264
Query: 332 LEKTNSKLQEELSAATDRICSLQEEQQQLREQNELIRERSEKSVEITKQDTKVELETYKQ 391
LEK+N+KL EEL+ A + I LQEE QLR +N+LI ++++ +E+TK D + EL+TYK
Sbjct: 265 LEKSNTKLIEELAIAKNNIIKLQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKH 324
Query: 392 TRQGLDEMYSDVWKQLKEEKKVRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVA 451
+RQGLDEMY++ +QL++E ++R ++E EL +Q+ MK E+E+AMKLLEKD HEKQDTL+
Sbjct: 325 SRQGLDEMYNEARRQLRDESQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIG 384
Query: 452 LRQQLEEVKAINLQMFHKAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSERA 511
LRQQLEEVKAIN++M+ K Q +E L++KNE I E KTN++ ++M+Q+E+RLQ +E+A
Sbjct: 385 LRQQLEEVKAINIEMYQKLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQRLQQAEKA 444
Query: 512 RQGAEERSHKLQQELGGRIGALQLQLSQLHEQCSSLEKELKSEKEQRQALQRELQHEKDT 571
+ AE+ K QE + +LQ Q+SQ +Q LE +LK EKE RQ LQ +LQ EKD
Sbjct: 445 QMEAEDEDEKYLQECLSKSDSLQKQISQKEKQLVQLETDLKIEKEWRQTLQEDLQKEKDA 504
Query: 572 SSLLRMELQQVEGLKKELRELQDEKAELQKICEEQEQALQEMGLHLSQSKLKMEDIKEVN 631
S LR E QQ+ LKKE LQDE +L+KI EQEQALQE+G LS+SKLK+EDIKE N
Sbjct: 505 LSHLRNETQQIISLKKEFLNLQDENQQLKKIYHEQEQALQELGNKLSESKLKIEDIKEAN 564
Query: 632 QALKGHAWLKDDEATHCRQCEKEFSISRRKHHCRNCGHIFCNTCSSNELALPSYPKPVRV 691
+AL+G WLKD EATHC+ CEKEFS+S+RKHHCRNCG IFCN CS NEL LPS PKPVRV
Sbjct: 565 KALQGLVWLKDKEATHCKLCEKEFSLSKRKHHCRNCGEIFCNACSDNELPLPSSPKPVRV 624
Query: 692 CDSCHTLLLQRCSS 705
CDSCH LL+QRCSS
Sbjct: 625 CDSCHALLIQRCSS 638
>gi|82697315 RUN and FYVE domain containing 3 isoform 1 [Homo
sapiens]
Length = 620
Score = 556 bits (1433), Expect = e-158
Identities = 303/600 (50%), Positives = 419/600 (69%), Gaps = 44/600 (7%)
Query: 109 MMEERANLMHMMKLSIKVLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHGLKVKKSFIG 168
M ER NLM+M KLSIK L++SAL+LGR+LD+D+APLQQFFVVMEHCLKHGLK KK+F+G
Sbjct: 65 MANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLG 124
Query: 169 QNKSFFGPLELVEKLCPEASDIATSVRNLPELKTAVGRGRAWLYLALMQKKLADYLKVLI 228
QNKSF+GPLELVEKL PEA++I SV++LP LKT VGRGRAWL LALMQKKL++Y+K LI
Sbjct: 125 QNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALI 184
Query: 229 DNKHLLSEFYEPEALMMEEEGMVIVGLLVGLNVLDANLCLKGEDLDSQVGVIDFSLYLKD 288
+ K LLSEFYEP ALMMEEEG +I GLLVGLNV+DAN C+KGEDLDSQVGVIDFS+YLKD
Sbjct: 185 NKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKD 244
Query: 289 VQDLDGGKEHERITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATD 348
G + +IT +LDQKNYVEELNRHL+ TV +LQ K+D LEK+N+KL EEL+ A +
Sbjct: 245 GNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANN 304
Query: 349 RICSLQEEQQQLREQNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLK 408
RI +LQEE ++++E++ I E + K KQD E + + R K LK
Sbjct: 305 RIITLQEEMERVKEESSYILESNRKG---PKQDRTAEGQALSEAR-----------KHLK 350
Query: 409 EEKKVRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFH 468
EE ++RL++EKELE+QI M+ EME+AMK+LEKD EKQD LV+LRQQL++++A+ ++
Sbjct: 351 EETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAF 410
Query: 469 KAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGG 528
K Q+++ ++QK+E + E KTNQ+ +++KQ+E+RL+ +ER+RQ AE + +Q+ G
Sbjct: 411 KLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFGD 470
Query: 529 RIGALQLQLSQLHEQCSSLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKE 588
+I +LQL++ +L Q + LE ELK EKE+R LQ+++ S+ Q+ E
Sbjct: 471 KINSLQLEVEELTRQRNQLELELKQEKERR------LQNDR---SIPGRGSQKSESKMDG 521
Query: 589 LRELQDEKAELQKICEEQEQALQEMGLHLSQSKLKMEDIKEVNQALKGHAWLKDDEATHC 648
++Q+E +L+K EE +L+ + E +Q L ++ C
Sbjct: 522 KHKMQEENVKLKKPLEESH-------------RLQPHPMDEQDQL------LLSEKPQLC 562
Query: 649 RQCEKEFSISRRKHHCRNCGHIFCNTCSSNELALPSYPKPVRVCDSCHTLLLQRCSSTAS 708
+ C+++ S++ K+ C+NC FC+ CS+NEL LPS K RVC+ CH L+++ S++ S
Sbjct: 563 QLCQEDGSLT--KNVCKNCSGTFCDACSTNELPLPSSIKLERVCNPCHKHLMKQYSTSPS 620
>gi|195220720 RUN and FYVE domain containing 3 isoform 3 [Homo
sapiens]
Length = 506
Score = 471 bits (1213), Expect = e-133
Identities = 263/499 (52%), Positives = 338/499 (67%), Gaps = 28/499 (5%)
Query: 9 AAGRGRELEPELEPGPG-PGSALEPGEEFEIVDRSQLPGPGDLRSATRP--RAAEGWSAP 65
A G + E E P P P EP PG G RP + W P
Sbjct: 33 APAGGTDREGEAGPPPASPAGQSEPDSPVAAPFFLLYPGDGGAGFGVRPPPQQQRSWRTP 92
Query: 66 ILTLARRATGNLSASCGSALRAAAGLGGGDSGDGTARAASKCQMMEERANLMHMMKLSIK 125
+ LS G GGG SG G + M ER NLM+M KLSIK
Sbjct: 93 PSPGSPLPFLLLSYPSG---------GGGSSGSG--KHHPNYLMANERMNLMNMAKLSIK 141
Query: 126 VLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHGLKVKKSFIGQNKSFFGPLELVEKLCP 185
L++SAL+LGR+LD+D+APLQQFFVVMEHCLKHGLK KK+F+GQNKSF+GPLELVEKL P
Sbjct: 142 GLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLGQNKSFWGPLELVEKLVP 201
Query: 186 EASDIATSVRNLPELKTAVGRGRAWLYLALMQKKLADYLKVLIDNKHLLSEFYEPEALMM 245
EA++I SV++LP LKT VGRGRAWL LALMQKKL++Y+K LI+ K LLSEFYEP ALMM
Sbjct: 202 EAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALINKKELLSEFYEPNALMM 261
Query: 246 EEEGMVIVGLLVGLNVLDANLCLKGEDLDSQVGVIDFSLYLKDVQDLDGGKEHERITDVL 305
EEEG +I GLLVGLNV+DAN C+KGEDLDSQVGVIDFS+YLKD G + +IT +L
Sbjct: 262 EEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKDGNSSKGTEGDGQITAIL 321
Query: 306 DQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQLREQNE 365
DQKNYVEELNRHL+ TV +LQ K+D LEK+N+KL EEL+ A +RI +LQEE ++++E++
Sbjct: 322 DQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESS 381
Query: 366 LIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLKEEKKVRLELEKELELQI 425
I E + K KQD E + + R K LKEE ++RL++EKELE+QI
Sbjct: 382 YILESNRKG---PKQDRTAEGQALSEAR-----------KHLKEETQLRLDVEKELEMQI 427
Query: 426 GMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQKNEAIT 485
M+ EME+AMK+LEKD EKQD LV+LRQQL++++A+ ++ K Q+++ ++QK+E +
Sbjct: 428 SMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNS 487
Query: 486 SFEGKTNQVMSSMKQMEER 504
E KTNQ+ +++KQ+E+R
Sbjct: 488 RLEEKTNQMAATIKQLEQR 506
>gi|7662352 RUN and FYVE domain containing 3 isoform 2 [Homo
sapiens]
Length = 469
Score = 463 bits (1191), Expect = e-130
Identities = 237/395 (60%), Positives = 308/395 (77%), Gaps = 14/395 (3%)
Query: 109 MMEERANLMHMMKLSIKVLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHGLKVKKSFIG 168
M ER NLM+M KLSIK L++SAL+LGR+LD+D+APLQQFFVVMEHCLKHGLK KK+F+G
Sbjct: 65 MANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLG 124
Query: 169 QNKSFFGPLELVEKLCPEASDIATSVRNLPELKTAVGRGRAWLYLALMQKKLADYLKVLI 228
QNKSF+GPLELVEKL PEA++I SV++LP LKT VGRGRAWL LALMQKKL++Y+K LI
Sbjct: 125 QNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALI 184
Query: 229 DNKHLLSEFYEPEALMMEEEGMVIVGLLVGLNVLDANLCLKGEDLDSQVGVIDFSLYLKD 288
+ K LLSEFYEP ALMMEEEG +I GLLVGLNV+DAN C+KGEDLDSQVGVIDFS+YLKD
Sbjct: 185 NKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKD 244
Query: 289 VQDLDGGKEHERITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATD 348
G + +IT +LDQKNYVEELNRHL+ TV +LQ K+D LEK+N+KL EEL+ A +
Sbjct: 245 GNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANN 304
Query: 349 RICSLQEEQQQLREQNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLK 408
RI +LQEE ++++E++ I E + K KQD E + + R K LK
Sbjct: 305 RIITLQEEMERVKEESSYILESNRKG---PKQDRTAEGQALSEAR-----------KHLK 350
Query: 409 EEKKVRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFH 468
EE ++RL++EKELE+QI M+ EME+AMK+LEKD EKQD LV+LRQQL++++A+ ++
Sbjct: 351 EETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAF 410
Query: 469 KAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEE 503
K Q+++ ++QK+E + E KTNQ+ +++KQ+E+
Sbjct: 411 KLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQ 445
>gi|109240552 RUN and FYVE domain-containing 2 isoform b [Homo
sapiens]
Length = 403
Score = 436 bits (1122), Expect = e-122
Identities = 224/400 (56%), Positives = 295/400 (73%), Gaps = 34/400 (8%)
Query: 104 ASKCQMMEERANLMHMMKLSIKVLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHGLKVK 163
A+K ERANL++M KLSIK L++SALS GR+LD+D+ PLQQFFVVMEHCLKHGLKV+
Sbjct: 2 ATKDPTAVERANLLNMAKLSIKGLIESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLKVR 61
Query: 164 KSFIGQNKSFFGPLELVEKLCPEASDIATSVRNLPELKTAVGRGRAWLYLALMQKKLADY 223
KSF+ NK+ +GPLELVEKL PEA +I SVR+LP
Sbjct: 62 KSFLSYNKTIWGPLELVEKLYPEAEEIGASVRDLPG------------------------ 97
Query: 224 LKVLIDNKHLLSEFYEPEALMMEEEGMVIVGLLVGLNVLDANLCLKGEDLDSQVGVIDFS 283
L+EFYE ALMMEEEG VIVGLLVGLNV+DANLC+KGEDLDSQVGVIDFS
Sbjct: 98 ----------LNEFYEYHALMMEEEGAVIVGLLVGLNVIDANLCVKGEDLDSQVGVIDFS 147
Query: 284 LYLKDVQDLDGGKEHERITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEEL 343
+YLK+ +D+ + + +I +LDQKNYVEELNR L+ TV L +++D LEK+N+KL EEL
Sbjct: 148 MYLKNEEDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEEL 207
Query: 344 SAATDRICSLQEEQQQLREQNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDV 403
+ A + I LQEE QLR +N+LI ++++ +E+TK D + EL+TYK +RQGLDEMY++
Sbjct: 208 AIAKNNIIKLQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEA 267
Query: 404 WKQLKEEKKVRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAIN 463
+QL++E ++R ++E EL +Q+ MK E+E+AMKLLEKD HEKQDTL+ LRQQLEEVKAIN
Sbjct: 268 RRQLRDESQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAIN 327
Query: 464 LQMFHKAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEE 503
++M+ K Q +E L++KNE I E KTN++ ++M+Q+E+
Sbjct: 328 IEMYQKLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQ 367
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 127 bits (319), Expect = 4e-29
Identities = 102/397 (25%), Positives = 186/397 (46%), Gaps = 40/397 (10%)
Query: 321 TVGDLQTKIDGLEKTNSKLQEELSAATDRICSLQEE----QQQLREQNELIRERSEKSVE 376
T LQ+ G E +++L + +++ QE+ + Q+ QN+LI+E
Sbjct: 1027 TFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKAT 1086
Query: 377 ITKQDTKVELETYKQTR--QGLDEMYSDVWKQLKEEKKVRLELEKELELQIGMKTEMEIA 434
+ + K E + ++ + Q + + S K+L EK E+E +I + E EI
Sbjct: 1087 LEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIE-----EIKCRQEKEIT 1141
Query: 435 MKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQKNEAITSFEGKTNQV 494
KL E+ K +++ + L++ K + +Q + Q SL+ A E + Q+
Sbjct: 1142 -KLNEELKSHKLESIKEITN-LKDAKQLLIQQKLELQGKADSLK----AAVEQEKRNQQI 1195
Query: 495 MSSMKQMEERLQHSERARQGAEERSHKLQQELGGRI-----GALQLQLSQLHEQCSSLEK 549
+ + EE E + A+ S ++E+G + L +Q++ L+E +++K
Sbjct: 1196 LKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKK 1255
Query: 550 ELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKK-----------ELRELQDEKAE 598
E +S + + L+++ + ++L +Q + ++ E+ +LQ + E
Sbjct: 1256 EWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLE 1315
Query: 599 LQKICEEQEQALQEMGLHLSQSKLKMEDIKEVNQALKGHAWLKDDEATHCRQCEKEFSIS 658
LQ+ + A+QE+G ++K QAL W +D+E +C C K FS++
Sbjct: 1316 LQRKLDNTTAAVQELGRENQSLQIKH------TQALN-RKWAEDNEVQNCMACGKGFSVT 1368
Query: 659 RRKHHCRNCGHIFCNTCSSNELALPSYPKPVRVCDSC 695
R+HHCR CG+IFC CS+ PS KPVRVCD+C
Sbjct: 1369 VRRHHCRQCGNIFCAECSAKNALTPSSKKPVRVCDAC 1405
Score = 78.2 bits (191), Expect = 2e-14
Identities = 103/476 (21%), Positives = 204/476 (42%), Gaps = 52/476 (10%)
Query: 178 ELVEKLCPEASDIATSVRNLPELKTAVGR--GRAWLYLALMQKKLADYLKVLIDNKHLLS 235
+L +L ++A V+ L +LK++V + + KK DY K ++ KH
Sbjct: 271 QLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTK--LEEKH--- 325
Query: 236 EFYEPEALMMEEEGMVIVGLLVGLNVLDANLCLKGEDLDSQVGVIDFSLYLKDVQDLDGG 295
EE + + L+ D L + L S++ + SL+ V+ + G
Sbjct: 326 ----------NEESVSKKNIQATLHQKD----LDCQQLQSRLSASETSLHRIHVELSEKG 371
Query: 296 KEHERITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICS--- 352
+ +++ + L + VE +HL LQ + + E+ +LQ E++ ++
Sbjct: 372 EATQKLKEELSE---VETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETER 428
Query: 353 -LQEEQQQLREQNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLKEEK 411
L E +L+EQ +L SEK ++ +Q ++L+ + Q L E ++ + +
Sbjct: 429 QLGEAHGRLKEQRQL---SSEKLMDKEQQVADLQLKLSRLEEQ-LKEKVTNSTELQHQLD 484
Query: 412 KVRLELEKELELQIGMKTEMEIAMKLLEK------DTHEKQDTLVALRQQLEEVKAINLQ 465
K + + +++ LQ ++ A LE+ D +K L AL Q+ +E N+
Sbjct: 485 KTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKE----NIS 540
Query: 466 MFHKAQNAESSLQQKNEAITS----FEGKTNQVMSSMKQMEERLQHSERARQGAEERSHK 521
+ K + + Q E T+ + K + + + Q+ E+L++ + + A+E H
Sbjct: 541 LLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHD 600
Query: 522 LQQELGGRIGALQLQLSQLHEQCSSLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQ 581
QE + A Q ++ L + L +L KE + Q ++Q + T LL E +
Sbjct: 601 QVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKE--KVSQLDIQIKAKTELLLSAEAAK 658
Query: 582 VEGLKKELRELQDEKAELQKICEEQEQALQEMGLHLSQSKLKMEDIKEVNQALKGH 637
+ +LQ+ Q ++++Q L ++ L Q K++D +E L+ H
Sbjct: 659 T----AQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESH 710
Score = 73.6 bits (179), Expect = 6e-13
Identities = 79/346 (22%), Positives = 157/346 (45%), Gaps = 22/346 (6%)
Query: 329 IDGLEKTNSKLQEELSAATDRICSLQEEQQQLREQ-NELIRERSEKSVEITKQDTKVELE 387
++ L++ N LQE+++ T+++ + E +Q +E ++ ++E +K+ QD + LE
Sbjct: 563 LNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQE--QKAHLRAAQDRVLSLE 620
Query: 388 T-YKQTRQGLDEMYSDVWKQLKEEKKVRLELEKELEL-QIGMKTEMEIAMKLLEKDTHEK 445
T + L+E V QL + K + EL E + + +++ + + +K
Sbjct: 621 TSVNELNSQLNESKEKV-SQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDK 679
Query: 446 QDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQKNEAITSFEGKTNQVMSSMKQME--- 502
Q L + QL++V A ES L++ E S E KT ++ +K++E
Sbjct: 680 QQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADS 739
Query: 503 -ERLQHSERARQGAEERSHKLQQELGGRIGALQLQLSQLHEQCSSLEKELKSEKEQRQAL 561
E E+A Q +++ +L +L R L QL E SS +L+ + E +++
Sbjct: 740 LEVKASKEQALQDLQQQ-RQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESI 798
Query: 562 QRELQHEKDTSSLLRMELQQVEGLKKELRE-----LQDEKAELQKICEEQEQALQEMG-- 614
+++L +++ +L+ + + + K E +Q ELQK+ E+E + E+
Sbjct: 799 KQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTV 858
Query: 615 ---LHLSQSKLKMEDIKEVNQALKGHAWLKDDEATHCRQCEKEFSI 657
L LK + + KG A + D E T C++ + + +
Sbjct: 859 KDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKT-CKELKHQLQV 903
Score = 73.2 bits (178), Expect = 8e-13
Identities = 87/396 (21%), Positives = 172/396 (43%), Gaps = 70/396 (17%)
Query: 313 ELNRHLSCTVGDLQTKIDGLEKTN-----------------SKLQEELSAATDRICSLQE 355
+L HL LQ K L K S+L+ L ++ SL++
Sbjct: 664 DLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQ 723
Query: 356 EQQQLREQNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLKEEKKV-- 413
+ ++L Q + + E V+ +K+ +L+ +Q L+ +++ KQL+ EK++
Sbjct: 724 KTEELEGQIKKL-EADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVS 782
Query: 414 --RLELEKELELQIGMK---TEMEIAMKLLEKD----------THEKQDTLV-------- 450
RL+L+K+ E +K T+ E ++L++D HE+ + +
Sbjct: 783 STRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQ 842
Query: 451 -------ALRQQLEEVKAINLQMFHKAQNAESSLQQKNE----AITSFEGKTNQVMSSMK 499
AL +L VK ++ +N++S +++N+ AI E ++ ++
Sbjct: 843 KVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQ 902
Query: 500 -QMEERLQHSERARQGAEERSHKLQQELGGRIGALQLQLSQLHEQCSSLEKELKSEKEQR 558
QME L+ + ++ E+ Q L+L+L+ + EQ + LK +++
Sbjct: 903 VQMENTLKEQKELKKSLEKEKEASHQ--------LKLELNSMQEQLIQAQNTLKQNEKEE 954
Query: 559 QALQRELQHEKDTSSLLRMELQQVEGLKKELRELQDEKAELQ-KICEEQEQALQEMGLH- 616
Q LQ + K +S + +Q+E L+ EL+ +K EL+ K+ ++ QA QE+
Sbjct: 955 QQLQGNINELKQSS---EQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEK 1011
Query: 617 --LSQSKLKMEDIKEVNQALKGHAWLKDDEATHCRQ 650
+S + E +E + L+ + ++ E RQ
Sbjct: 1012 EKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQ 1047
Score = 71.2 bits (173), Expect = 3e-12
Identities = 92/440 (20%), Positives = 190/440 (43%), Gaps = 64/440 (14%)
Query: 263 DANLCLKGEDLDSQVGVIDFSLYLKDVQDLDGGKEHERITDVLDQKNYVEELNRHLSCTV 322
++NL LK +D+ +L ++VQDL + E K Y EEL + L
Sbjct: 75 ESNLALKRDDV---------TLLRQEVQDLQASLKEE--------KWYSEELKKELEKYQ 117
Query: 323 G--DLQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQLREQNELIRERSEK-SVEITK 379
G + K DGL +S EL + ++ Q E +++ +L +++ + + EI
Sbjct: 118 GLQQQEAKPDGLVTDSSA---ELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIA- 173
Query: 380 QDTKVELETYKQTRQGLDEMYSDVWKQLKEEKKVRLELEKELELQIG------MKTEMEI 433
D K + + + R+ ++ + + ++L +E V +L+ EL + G +K E+
Sbjct: 174 -DIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQ 232
Query: 434 AMKLLEKDTHEKQD---------------------TLVALRQQL----EEVKAINLQMFH 468
L++ T E++ T+ LR +L +EV A+ +Q
Sbjct: 233 VQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEV-AVYVQELQ 291
Query: 469 KAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGG 528
K +++ + L QKN+ +T K Q + +++ S++ Q + Q+L
Sbjct: 292 KLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQS 351
Query: 529 RIGALQLQLSQLHEQCSSLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQVE----G 584
R+ A + L ++H + S + + KE+ ++ + QH K L+ + ++ E
Sbjct: 352 RLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQ 411
Query: 585 LKKELRELQDEKAELQKICEEQEQALQEMGLHLSQSKL--KMEDIKEVNQALKGHAWLKD 642
L+ E+ +L + E ++ E L+E LS KL K + + ++ L
Sbjct: 412 LQSEINQLHSKLLETERQLGEAHGRLKEQ-RQLSSEKLMDKEQQVADLQLKLSRLEEQLK 470
Query: 643 DEATHCRQCEKEFSISRRKH 662
++ T+ + + + ++++H
Sbjct: 471 EKVTNSTELQHQLDKTKQQH 490
Score = 63.5 bits (153), Expect = 6e-10
Identities = 87/420 (20%), Positives = 182/420 (43%), Gaps = 90/420 (21%)
Query: 312 EELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQLREQNELIRERS 371
+ELN+ ++ + + K+ ++ S+L+ L ++ SL+++ ++L Q + + E
Sbjct: 681 QELNK-ITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKL-EAD 738
Query: 372 EKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLKEEKKV----RLELEKELELQIGM 427
V+ +K+ +L+ +Q L+ +++ KQL+ EK++ RL+L+K+ E +
Sbjct: 739 SLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESI 798
Query: 428 K---TEMEIAMKLLEKD----------THEKQDTLV---------------ALRQQLEEV 459
K T+ E ++L++D HE+ + + AL +L V
Sbjct: 799 KQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTV 858
Query: 460 KAINLQMFHKAQNAESSLQQKNE----AITSFEGKTNQVMSSMK-QMEERLQHSERARQG 514
K ++ +N++S +++N+ AI E ++ ++ QME L+ + ++
Sbjct: 859 KDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKS 918
Query: 515 AE---ERSHKL------------------------QQELGGRIGALQLQLSQLHEQCSSL 547
E E SH+L +Q+L G I L+ Q +Q +L
Sbjct: 919 LEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEAL 978
Query: 548 EKELKSEKEQRQALQRELQH-----------EKDTSSLLRMELQQVEGLKKELRE----- 591
+ ELK Q+ L+ +LQ EK+ S+L+ ++ + K+L+
Sbjct: 979 QGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGR 1038
Query: 592 -------LQDEKAELQKICEEQEQALQEMGLHLSQSKLKMEDIKEVNQALKGHAWLKDDE 644
QD K+ +K+ QE + +Q+KL ++++K L+ + K+ +
Sbjct: 1039 ESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKL-IQELKTAKATLEQDSAKKEQQ 1097
>gi|157738667 FYVE and coiled-coil domain containing 1 [Homo sapiens]
Length = 1478
Score = 117 bits (292), Expect = 5e-26
Identities = 105/441 (23%), Positives = 188/441 (42%), Gaps = 61/441 (13%)
Query: 316 RHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQLREQNELI-RERSEKS 374
+ L V DLQ K+ K+Q +LS A + + QQL+EQNE + R ++
Sbjct: 786 QRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQEL 845
Query: 375 VEITKQDTKVELETYKQTRQ------GLDEMYSDVWKQLKEEKKVRLELEKELELQIGMK 428
++ ++++ ++ E + +Q L E S +E + EL+++L
Sbjct: 846 LQCSEREGALQEERADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQEQLHRANTDT 905
Query: 429 TEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQKNEAITSFE 488
E+ I + L + ++ L Q+L++ K + + + LQQ+ E++
Sbjct: 906 AELGIQVCALTVEKERVEEALACAVQELQDAKEAASREREGLERQVAGLQQEKESLQEKL 965
Query: 489 GKTNQVMSSMKQMEERLQHSERARQGAEERSHK----LQQELGGRIGALQLQLSQLHEQC 544
S+ ++ +L +E+ Q +E +H+ L+ +L I Q +L E+C
Sbjct: 966 KAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLSAEIMDYQSRLKNAGEEC 1025
Query: 545 SSLEKELKSEKEQRQALQRELQHEKDT-------------------SSLLRMELQQV--- 582
SL +L+ + Q QA + ++ K T +++LR + +
Sbjct: 1026 KSLRGQLEEQGRQLQAAEEAVEKLKATQADMGEKLSCTSNHLAECQAAMLRKDKEGAALR 1085
Query: 583 EGLKKELRELQDEKAELQ----KICEE--------------------QEQALQEMGLHLS 618
E L++ +EL+ ++Q K+C+E ++ L+E + L
Sbjct: 1086 EDLERTQKELEKATTKIQEYYNKLCQEVTNRERNDQKMLADLDDLNRTKKYLEERLIELL 1145
Query: 619 QSK---LKMEDIKEVNQALKGHA-WLKDDEATHCRQCEKEFSISRRKHHCRNCGHIFCNT 674
+ K + D E Q L WL D EA HC C++EFS R+HHCR CG IFC
Sbjct: 1146 RDKDALWQKSDALEFQQKLSAEERWLGDTEANHCLDCKREFSWMVRRHHCRICGRIFCYY 1205
Query: 675 CSSNELALPSYPKPVRVCDSC 695
C +N + K R C +C
Sbjct: 1206 CCNNYVLSKHGGKKERCCRAC 1226
Score = 103 bits (256), Expect = 7e-22
Identities = 119/530 (22%), Positives = 228/530 (43%), Gaps = 52/530 (9%)
Query: 135 GRSLDADHAPLQQFFVVMEHCLKHGLKVKKSFIGQNKSFFGPLELVEKLCPEASDIATSV 194
G + D L +F +E+ L+ K K + +G K ++ A+D V
Sbjct: 32 GEPITDDSTSLHKFSYKLEYLLQFDQKEKATLLGNKKDYWDYFCACLAKVKGANDGIRFV 91
Query: 195 RNLPELKTAVGRGRAWLYLALMQKKLADYLKVLIDNKHLLSEFYEPEALMMEEE-GMVIV 253
+++ EL+T++G+GRA++ +L+ ++LAD L+ N + S++Y + ++ + IV
Sbjct: 92 KSISELRTSLGKGRAFIRYSLVHQRLADTLQQCFMNTKVTSDWYYARSPFLQPKLSSDIV 151
Query: 254 GLLVGLNVLDANLCLKGEDLDS-------QVGVIDFSLYLKDVQDLDGG-----KEHERI 301
G L L + +L +G DLD+ + S YL + +
Sbjct: 152 GQLYELTEVQFDLASRGFDLDAAWPTFARRTLTTGSSAYLWKPPSRSSSMSSLVSSYLQT 211
Query: 302 TDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQLR 361
+++ + LN +++ ++D LE +L+E + L+ Q
Sbjct: 212 QEMVSNFDLNSPLNNEALEGFDEMRLELDQLEVREKQLRERMQQLDRENQELRAAVSQQG 271
Query: 362 EQNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLKEEKKVRLELEKEL 421
EQ + RER + E + T + E KQ W+ + + EL+ L
Sbjct: 272 EQLQTERERGRTAAEDNVRLTCLVAELQKQ------------WEVTQATQNTVKELQTCL 319
Query: 422 ELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQL-EEVKAINLQMFHKAQNAES----- 475
+ +E+ E+D H L ++ Q L +E++A + K Q+ S
Sbjct: 320 Q-------GLELGAAEKEEDYHTALRRLESMLQPLAQELEATRDSLDKKNQHLASFPGWL 372
Query: 476 -SLQQKNEAITSFEGKTNQVMS----SMKQMEERLQHSERARQGAEERSHKLQQELGGRI 530
QQK + + +G+ + S M+++ E+LQ ER R EE + + +L +
Sbjct: 373 AMAQQKADTASDTKGRQEPIPSDAAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQLV 432
Query: 531 GALQLQ------LSQLHEQCSSLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEG 584
LQL+ L +L ++ + L++EL + ++ L R LQ +S EL +
Sbjct: 433 KELQLKEDARASLERLVKEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAE--- 489
Query: 585 LKKELRELQDEKAELQKICEEQEQALQEMGLHLSQSKLKMEDIKEVNQAL 634
L++E ++ Q+EK L++ + LQ + L+Q + D++E + L
Sbjct: 490 LRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQL 539
Score = 62.4 bits (150), Expect = 1e-09
Identities = 84/394 (21%), Positives = 166/394 (42%), Gaps = 44/394 (11%)
Query: 325 LQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQLREQNELIRER-------------- 370
L+ ++ L + L+ +L+ + + L+E+++QL + + + ++
Sbjct: 504 LEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPE 563
Query: 371 ----SEKSVEITKQDTKVELETYK--QTRQGLDEMYSDVWK-----QLKEEKKVRLELEK 419
EK+ + ++ ++ K + ++GL E D K Q +E ++ ELEK
Sbjct: 564 LPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQEEELRQANRELEK 623
Query: 420 ELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQ 479
EL+ +G +E ++ L+ D Q A++ L ++A + H E+SL
Sbjct: 624 ELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAEQASIRHLGDQMEASLLA 683
Query: 480 KNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGGRIGALQLQLSQ 539
+A + + M + E LQ E Q E + QQ R L+ SQ
Sbjct: 684 VRKA-------KEAMKAQMAEKEAILQSKEGECQQLREEVEQCQQLAEARHRELRALESQ 736
Query: 540 LHEQCSSLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKELRELQ----DE 595
+Q +E L +EK Q+ ++ ++ L + Q+E + E++ LQ D
Sbjct: 737 CQQQTQLIE-VLTAEKGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQRLQAQVVDL 795
Query: 596 KAELQKICEEQEQALQEMGLH---LSQSKLKMEDIKEVNQAL-KGHA--WLKDDEATHCR 649
+A+++ ++Q++ ++ + L + K ++ +KE N+AL + H L+ E
Sbjct: 796 QAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQCSEREGAL 855
Query: 650 QCEKEFSISRRKHHCRNCGHIFCNT-CSSNELAL 682
Q E+ +R+ R CSS E L
Sbjct: 856 QEERADEAQQREEELRALQEELSQAKCSSEEAQL 889
Score = 61.6 bits (148), Expect = 2e-09
Identities = 69/348 (19%), Positives = 156/348 (44%), Gaps = 19/348 (5%)
Query: 296 KEHERITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICS-LQ 354
+++ R+T ++ + E+ + TV +LQT + GLE ++ +E+ A R+ S LQ
Sbjct: 286 EDNVRLTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALRRLESMLQ 345
Query: 355 EEQQQLREQNELIRERSEKSVEITK--QDTKVELETYKQTRQGLDEMYSDVWKQLKEEKK 412
Q+L + + ++++ + + +T T+ + + SD ++++E +
Sbjct: 346 PLAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGE 405
Query: 413 VRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQN 472
LE+E + + ++ L K+ K+D +L + ++E+ + ++ K Q
Sbjct: 406 KLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMAPLQEELSGKGQE 465
Query: 473 AESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQE---LGGR 529
A+ ++ E +++ EE L R ++ +E L+QE L +
Sbjct: 466 ADQLWRRLQE-----------LLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQ 514
Query: 530 IGALQLQLSQLHEQCSSLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKEL 589
+ L+ QL+Q+ + S LE++ K + + L +++ + + EL + L
Sbjct: 515 LQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPELPVAGEKNEAL 574
Query: 590 RELQDEKAELQKICEEQEQALQEMGLHLS--QSKLKMEDIKEVNQALK 635
+ E EE+++ LQE L + Q + E++++ N+ L+
Sbjct: 575 VPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQEEELRQANRELE 622
>gi|197304746 RUN domain containing 3B isoform c [Homo sapiens]
Length = 407
Score = 114 bits (286), Expect = 2e-25
Identities = 91/336 (27%), Positives = 162/336 (48%), Gaps = 21/336 (6%)
Query: 84 ALRAAAGLGG--GDSGDGTARAASKCQMMEERANLMHMMKLSIKVLLQSALSLGRSLDAD 141
A R+ GL G G G G ++ S ER NL+ + + S+K L+ S ++D
Sbjct: 2 ASRSLGGLSGIRGGGGGGGKKSLSARNAAVERRNLITVCRFSVKTLIDR--SCFETIDDS 59
Query: 142 HAPLQQFFVVMEHCLKHGLKVKKSFIGQN--KSFFGPLELVEKLCPEAS-DIATSVRNLP 198
F ++E L H LK + ++ G +SF+ + + C + S + S+ N+
Sbjct: 60 SPEFNNFAAILEQILSHRLKGQVTWFGYESPRSFW---DYIRVACRKVSQNCICSIENME 116
Query: 199 ELKTAVGRGRAWLYLALMQKKLADYLKVLIDNKHLLSEFYEPEALMMEEEGMVIVGLLVG 258
+ ++ +GRAW+ +ALM+K L++Y+ + + FYE A+++ EE ++ G+L+G
Sbjct: 117 NVSSSRAKGRAWIRVALMEKHLSEYISTALRDFKTTRRFYEDGAIVLGEEANMLAGMLLG 176
Query: 259 LNVLDANLCLKGEDLD-SQVGVIDFSLYLKDVQDLDGGKEHERITDVLDQKNYVEELNRH 317
LN +D + CLKGE LD S VID++ YLK +Q D E L +
Sbjct: 177 LNAIDFSFCLKGEGLDGSFPAVIDYTPYLKYIQSSDSISSDEEELRTLGSSGSESSTPEN 236
Query: 318 LSCT-VGDLQTKIDGLEKTNSKLQ--EELSAATDRICSLQEEQ-QQLREQNELIRERSEK 373
+ + D + + ++ K Q E + + L+E Q + QN+++ +R E
Sbjct: 237 VGPPFLMDENSWFNKCKRVKQKYQLTLEQKGYLEELLRLRENQLSESVSQNKILLQRIED 296
Query: 374 SVEITKQDTK------VELETYKQTRQGLDEMYSDV 403
S K + + VEL+ ++ Q LD++ ++V
Sbjct: 297 SDLAHKLEKEQLEYIIVELQDQLKSYQSLDQLSAEV 332
>gi|197304744 RUN domain containing 3B isoform b [Homo sapiens]
Length = 456
Score = 113 bits (283), Expect = 5e-25
Identities = 103/387 (26%), Positives = 174/387 (44%), Gaps = 74/387 (19%)
Query: 84 ALRAAAGLGG--GDSGDGTARAASKCQMMEERANLMHMMKLSIKVLLQSALSLGRSLDAD 141
A R+ GL G G G G ++ S ER NL+ + + S+K L+ S ++D
Sbjct: 2 ASRSLGGLSGIRGGGGGGGKKSLSARNAAVERRNLITVCRFSVKTLIDR--SCFETIDDS 59
Query: 142 HAPLQQFFVVMEHCLKHGLKVKKSFIGQN--KSFFGPLELVEKLCPEAS-DIATSVRNLP 198
F ++E L H LK + ++ G +SF+ + + C + S + S+ N+
Sbjct: 60 SPEFNNFAAILEQILSHRLKGQVTWFGYESPRSFW---DYIRVACRKVSQNCICSIENME 116
Query: 199 ELKTAVGRGRAWLYLALMQKKLADYLKVLIDNKHLLSEFYEPEALMMEEEGMVIVGLLVG 258
+ ++ +GRAW+ +ALM+K L++Y+ + + FYE A+++ EE ++ G+L+G
Sbjct: 117 NVSSSRAKGRAWIRVALMEKHLSEYISTALRDFKTTRRFYEDGAIVLGEEANMLAGMLLG 176
Query: 259 LNVLDANLCLKGEDLD-SQVGVIDFSLYLKDVQDLD--------------GGKEHERITD 303
LN +D + CLKGE LD S VID++ YLK +Q D G E +
Sbjct: 177 LNAIDFSFCLKGEGLDGSFPAVIDYTPYLKYIQSSDSISSDEEELRTLGSSGSESSTPEN 236
Query: 304 V-------------------------LDQKNYVEELNR----HLSCTVGDLQTKIDGLEK 334
V L+QK Y+EEL R LS +V + + +E
Sbjct: 237 VGPPFLMDENSWFNKCKRVKQKYQLTLEQKGYLEELLRLRENQLSESVSQNKILLQRIED 296
Query: 335 TNSKLQEELSAATDRICSLQEEQQQLREQNELIRERSEKSVEITKQ-------------- 380
++ + E I LQ++ L+ N +R R E + +T Q
Sbjct: 297 SDLAHKLEKEQLEYIIVELQDQLTVLK--NNDLRSRQELTAHLTNQWPSPGALDVNAVAL 354
Query: 381 DT----KVELETYKQTRQGLDEMYSDV 403
DT K + Y+++ Q LD++ ++V
Sbjct: 355 DTLLYRKHNKQWYEKSYQSLDQLSAEV 381
>gi|221307580 RUN domain containing 3A isoform 3 [Homo sapiens]
Length = 400
Score = 108 bits (269), Expect = 2e-23
Identities = 83/323 (25%), Positives = 146/323 (45%), Gaps = 58/323 (17%)
Query: 100 TARAASKCQMMEERANLMHMMKLSIKVLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHG 159
+++ AS + ER NL+ + + S+K LL+ + +D F ++E L H
Sbjct: 15 SSKKASSRNVAVERKNLITVCRFSVKTLLEKYTA--EPIDDSSEEFVNFAAILEQILSHR 72
Query: 160 LKVKKSFIGQN--KSFFGPLELVEKLCPEASDIATSVRNLPELKTAVGRGRAWLYLALMQ 217
K S+ + + F+ + L P ++ +S+ N+ + TA +GRAW+ +ALM+
Sbjct: 73 FKGPVSWFSSDGQRGFWDYIRLACSKVP--NNCVSSIENMENISTARAKGRAWIRVALME 130
Query: 218 KKLADYLKVLIDNKHLLSEFYEPEALMMEEEGMVIVGLLVGLNVLDANLCLKGEDLDSQV 277
K++++Y+ + + FY+ A+M+ +E ++ G+L+GL+ +D + CLKGE LD +
Sbjct: 131 KRMSEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAIDFSFCLKGEVLDGKT 190
Query: 278 G-VIDFSLYLKDVQDL------------------DGGKEHERITDVLD------------ 306
VID++ YLK Q D EH + V D
Sbjct: 191 PVVIDYTPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYSKWHKME 250
Query: 307 --------QKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQ 358
QK Y+EEL R ++++ LE N +LQ +L A + Q+
Sbjct: 251 QKFRIVYAQKGYLEELVRL-------RESQLKDLEAENRRLQLQLEEAA------AQNQR 297
Query: 359 QLREQNELIRERSEKSVEITKQD 381
+ RE +I E E+ + D
Sbjct: 298 EKRELEGVILELQEQLTGLIPSD 320
>gi|19923090 RUN domain containing 3B isoform a [Homo sapiens]
Length = 473
Score = 103 bits (258), Expect = 4e-22
Identities = 103/405 (25%), Positives = 172/405 (42%), Gaps = 93/405 (22%)
Query: 84 ALRAAAGLGG--GDSGDGTARAASKCQMMEERANLMHMMKLSIKVLLQSALSLGRSLDAD 141
A R+ GL G G G G ++ S ER NL+ + + S+K L+ S ++D
Sbjct: 2 ASRSLGGLSGIRGGGGGGGKKSLSARNAAVERRNLITVCRFSVKTLIDR--SCFETIDDS 59
Query: 142 HAPLQQFFVVMEHCLKHGLKVKKSFIGQNKSFFGPLEL--------------------VE 181
F ++E L H LK I Q+ + L++ +
Sbjct: 60 SPEFNNFAAILEQILSHRLKE----ISQSCRWLAHLQIPLQGQVTWFGYESPRSFWDYIR 115
Query: 182 KLCPEAS-DIATSVRNLPELKTAVGRGRAWLYLALMQKKLADYLKVLIDNKHLLSEFYEP 240
C + S + S+ N+ + ++ +GRAW+ +ALM+K L++Y+ + + FYE
Sbjct: 116 VACRKVSQNCICSIENMENVSSSRAKGRAWIRVALMEKHLSEYISTALRDFKTTRRFYED 175
Query: 241 EALMMEEEGMVIVGLLVGLNVLDANLCLKGEDLD-SQVGVIDFSLYLKDVQDLD------ 293
A+++ EE ++ G+L+GLN +D + CLKGE LD S VID++ YLK +Q D
Sbjct: 176 GAIVLGEEANMLAGMLLGLNAIDFSFCLKGEGLDGSFPAVIDYTPYLKYIQSSDSISSDE 235
Query: 294 --------GGKEHERITDV-------------------------LDQKNYVEELNR---- 316
G E +V L+QK Y+EEL R
Sbjct: 236 EELRTLGSSGSESSTPENVGPPFLMDENSWFNKCKRVKQKYQLTLEQKGYLEELLRLREN 295
Query: 317 HLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQLREQNELIRERSEKSVE 376
LS +V + + +E ++ + E I LQ++ L+ N +R R E +
Sbjct: 296 QLSESVSQNKILLQRIEDSDLAHKLEKEQLEYIIVELQDQLTVLK--NNDLRSRQELTAH 353
Query: 377 ITKQ--------------DT----KVELETYKQTRQGLDEMYSDV 403
+T Q DT K + Y+++ Q LD++ ++V
Sbjct: 354 LTNQWPSPGALDVNAVALDTLLYRKHNKQWYEKSYQSLDQLSAEV 398
>gi|221307578 RUN domain containing 3A isoform 1 [Homo sapiens]
Length = 446
Score = 103 bits (257), Expect = 5e-22
Identities = 85/329 (25%), Positives = 146/329 (44%), Gaps = 65/329 (19%)
Query: 100 TARAASKCQMMEERANLMHMMKLSIKVLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHG 159
+++ AS + ER NL+ + + S+K LL+ + +D F ++E L H
Sbjct: 15 SSKKASSRNVAVERKNLITVCRFSVKTLLEKYTA--EPIDDSSEEFVNFAAILEQILSHR 72
Query: 160 LKVKK--------SFIGQNKSFFGPLELVEKLCPEASDIATSVRNLPELKTAVGRGRAWL 211
K S GQ + F+ + L P ++ +S+ N+ + TA +GRAW+
Sbjct: 73 FKACAPAGPVSWFSSDGQ-RGFWDYIRLACSKVP--NNCVSSIENMENISTARAKGRAWI 129
Query: 212 YLALMQKKLADYLKVLIDNKHLLSEFYEPEALMMEEEGMVIVGLLVGLNVLDANLCLKGE 271
+ALM+K++++Y+ + + FY+ A+M+ +E ++ G+L+GL+ +D + CLKGE
Sbjct: 130 RVALMEKRMSEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAIDFSFCLKGE 189
Query: 272 DLDSQVG-VIDFSLYLKDVQDL------------------DGGKEHERITDVLD------ 306
LD + VID++ YLK Q D EH + V D
Sbjct: 190 VLDGKTPVVIDYTPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYS 249
Query: 307 --------------QKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICS 352
QK Y+EEL R ++++ LE N +LQ +L A
Sbjct: 250 KWHKMEQKFRIVYAQKGYLEELVRL-------RESQLKDLEAENRRLQLQLEEAA----- 297
Query: 353 LQEEQQQLREQNELIRERSEKSVEITKQD 381
+ Q++ RE +I E E+ + D
Sbjct: 298 -AQNQREKRELEGVILELQEQLTGLIPSD 325
>gi|5730015 RUN domain containing 3A isoform 2 [Homo sapiens]
Length = 405
Score = 103 bits (257), Expect = 5e-22
Identities = 85/329 (25%), Positives = 146/329 (44%), Gaps = 65/329 (19%)
Query: 100 TARAASKCQMMEERANLMHMMKLSIKVLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHG 159
+++ AS + ER NL+ + + S+K LL+ + +D F ++E L H
Sbjct: 15 SSKKASSRNVAVERKNLITVCRFSVKTLLEKYTA--EPIDDSSEEFVNFAAILEQILSHR 72
Query: 160 LKVKK--------SFIGQNKSFFGPLELVEKLCPEASDIATSVRNLPELKTAVGRGRAWL 211
K S GQ + F+ + L P ++ +S+ N+ + TA +GRAW+
Sbjct: 73 FKACAPAGPVSWFSSDGQ-RGFWDYIRLACSKVP--NNCVSSIENMENISTARAKGRAWI 129
Query: 212 YLALMQKKLADYLKVLIDNKHLLSEFYEPEALMMEEEGMVIVGLLVGLNVLDANLCLKGE 271
+ALM+K++++Y+ + + FY+ A+M+ +E ++ G+L+GL+ +D + CLKGE
Sbjct: 130 RVALMEKRMSEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAIDFSFCLKGE 189
Query: 272 DLDSQVG-VIDFSLYLKDVQDL------------------DGGKEHERITDVLD------ 306
LD + VID++ YLK Q D EH + V D
Sbjct: 190 VLDGKTPVVIDYTPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYS 249
Query: 307 --------------QKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICS 352
QK Y+EEL R ++++ LE N +LQ +L A
Sbjct: 250 KWHKMEQKFRIVYAQKGYLEELVRL-------RESQLKDLEAENRRLQLQLEEAA----- 297
Query: 353 LQEEQQQLREQNELIRERSEKSVEITKQD 381
+ Q++ RE +I E E+ + D
Sbjct: 298 -AQNQREKRELEGVILELQEQLTGLIPSD 325
>gi|58530840 desmoplakin isoform I [Homo sapiens]
Length = 2871
Score = 91.7 bits (226), Expect = 2e-18
Identities = 77/360 (21%), Positives = 171/360 (47%), Gaps = 22/360 (6%)
Query: 302 TDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEE-------LSAATDRICSLQ 354
T++ K + +L + +ID L + N L EE L+ T+ + ++
Sbjct: 1368 TEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVE 1427
Query: 355 EEQQQLREQNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLKEEKKVR 414
E+ QQ + + +R ++ +Q T++ E + +Q LD+ + + KE ++++
Sbjct: 1428 EDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLK 1487
Query: 415 LELEKELELQIGMKTEMEIAMKL---LEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQ 471
++KE + ++ E ++ L+K +T+ L+ Q +E+ + + +Q
Sbjct: 1488 QLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQ 1547
Query: 472 NAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGGRIG 531
K++ IT F+ ++ +++EE L +R + KL++EL G
Sbjct: 1548 ERTV----KDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRR 1603
Query: 532 ALQLQ------LSQLHEQCSSLEKELKSE-KEQRQALQRELQHEKDTSSLLRMELQQVEG 584
+L+ Q L+Q EQ S ++K + + ++QR L L+ ++ T LR +VE
Sbjct: 1604 SLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEA 1663
Query: 585 LKKELRELQDEKAELQKICEEQEQALQEMGLHLSQSKLKMEDIKEVNQAL-KGHAWLKDD 643
L+++L + Q+ + E ++A+++ L++SK+++E ++ + + L K H L+++
Sbjct: 1664 LRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEE 1723
Score = 69.7 bits (169), Expect = 9e-12
Identities = 89/365 (24%), Positives = 165/365 (45%), Gaps = 51/365 (13%)
Query: 293 DGGKEHERITDVLDQ----KNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQ-EELSAAT 347
D KE ER+ ++D+ + +E+ N L DLQ +T +KL+ +E
Sbjct: 1478 DKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTR 1537
Query: 348 DRICSLQEEQQQLREQNELIR-ERSEKSVEITKQDTKVELETYKQT-------RQGLDEM 399
RI + Q++ + ++ R + S K +++ KQ + EL K+T R+ L+E
Sbjct: 1538 LRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEE 1597
Query: 400 YSDVWKQLKEEKKVRLELEKELELQIGMKTEMEIAMK----LLEKDTHEKQDTLVALRQQ 455
+ + LKE+ L ++LE +K E ++ +L+ EKQ T LR+
Sbjct: 1598 LEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRL 1657
Query: 456 LEEVKAINLQM----------------FHKA-QNAESSLQQKNEAITSFEGKTNQVMSSM 498
EV+A+ Q+ F KA ++ SL + I + T +
Sbjct: 1658 SSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEH 1717
Query: 499 KQMEE-----RLQHSERARQGAEERSHK------LQQEL---GGRIGALQLQLSQLHEQC 544
+EE RL++ + R +E S K L+ +L R LQ ++ L +
Sbjct: 1718 LMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRER 1777
Query: 545 SSLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKELRELQDEKAELQKICE 604
+L +E+ EK Q+QAL+ + ++ + ++ +Q+ E L +++ L+ +KA LQ++ +
Sbjct: 1778 ENLRQEI--EKFQKQALEASNRIQESKNQCTQV-VQERESLLVKIKVLEQDKARLQRLED 1834
Query: 605 EQEQA 609
E +A
Sbjct: 1835 ELNRA 1839
Score = 62.4 bits (150), Expect = 1e-09
Identities = 84/457 (18%), Positives = 181/457 (39%), Gaps = 98/457 (21%)
Query: 302 TDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQLR 361
T++ K ++E++ +L+ ++D L + N L++E+ D I E++++
Sbjct: 1212 TEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRA- 1270
Query: 362 EQNELIRERSEKSVEITKQDTKVELETYKQTR--------QGLDEMYSDVWKQLKEEKKV 413
E+N L ++ + KQ ++EL+ Q R Q L+E + + KE +++
Sbjct: 1271 EENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERL 1330
Query: 414 RLELEKE----------------------LELQIGMKTEMEIAMKLLEKDTHEKQDTLVA 451
+ E ++E + L+ +TE+ I + + T +K++
Sbjct: 1331 KAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTSG 1390
Query: 452 LRQQLEEVKAINLQMFHKAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSE-- 509
R Q++ + N + + + +++L Q E + E Q ++ ++ +R Q E
Sbjct: 1391 YRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVE 1450
Query: 510 --RARQGAEERSHKLQQELGGRIGALQ------LQLSQLHEQCSSLEKELKSEKEQRQAL 561
+ Q E S + +Q L +Q +L QL ++ ++ K L+ E + Q +
Sbjct: 1451 LRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRV 1510
Query: 562 QRELQHEKDTSS------------LLRMEL-------------QQVEGLKKELRELQDEK 596
Q +LQ +++ L R+ + Q + + L+ELQ +K
Sbjct: 1511 QYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQK 1570
Query: 597 AELQK------------ICEEQ--EQALQEMGLHLSQSKLKM------------------ 624
++++ C+ + E+ L+ M L + +K+
Sbjct: 1571 QKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSE 1630
Query: 625 EDIKEVNQALKGHAWLKDDEATHCRQCEKEFSISRRK 661
+D+++ L GH K R+ E RR+
Sbjct: 1631 DDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQ 1667
Score = 58.2 bits (139), Expect = 3e-08
Identities = 85/397 (21%), Positives = 167/397 (42%), Gaps = 35/397 (8%)
Query: 287 KDVQDLDGGKEHERITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAA 346
+ V+D D + + ++ QK VEE L T + K LE+ ++ L
Sbjct: 1549 RTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQ 1608
Query: 347 TDRICSLQEEQQQLREQNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDV--- 403
+I +L QQL EQ ++++RSE + + L ++T++ L + S+V
Sbjct: 1609 AIKITNL---TQQL-EQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEAL 1664
Query: 404 -WKQLKEEKKVRL------ELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQL 456
+ L+E++ V+ +K +E + E +I ++ L+ T + L
Sbjct: 1665 RRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLE--- 1721
Query: 457 EEVKAINLQMFHKAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAE 516
EE++ + L+ + + KN I + + +++ + +R R+
Sbjct: 1722 EELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLR 1781
Query: 517 ERSHKLQQ---ELGGRIGALQLQLSQLHEQCSSL---EKELKSEKEQRQALQRELQHEKD 570
+ K Q+ E RI + Q +Q+ ++ SL K L+ +K + Q L+ EL K
Sbjct: 1782 QEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKS 1841
Query: 571 T-------SSLLRMELQQVEGLKKELRELQDEKAE-LQKICEEQEQALQEMGLHLSQSKL 622
T L E QQ++ + + K E ++KI E+E++ +E S+ +
Sbjct: 1842 TLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIER 1901
Query: 623 KMEDIKEVNQALKGHAWLKDDEATHCRQCEKEFSISR 659
+IK + + + K +++T Q + E SR
Sbjct: 1902 LQAEIKRIEERCR----RKLEDSTRETQSQLETERSR 1934
Score = 57.4 bits (137), Expect = 5e-08
Identities = 77/351 (21%), Positives = 146/351 (41%), Gaps = 18/351 (5%)
Query: 234 LSEFYEPEALMMEEEGMVIVGLLVGLNVLDANLCLKGEDLDSQVGVIDFSLYLK-----D 288
L E E ++E+ + I L L +DL Q V+D L K +
Sbjct: 1594 LEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEE 1653
Query: 289 VQDLDGGKEHERITDVLDQKNYVEEL---NRHLSCTVGDLQTKIDGLEKTNSKLQEELSA 345
++ L E R +L ++ V++ N H + D ++ + +LQ
Sbjct: 1654 LRRLSSEVEALR-RQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTEN 1712
Query: 346 ATDRICSLQEEQQQLR-EQNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVW 404
T L+EE + LR E ++L R RSE + K T +EL + Q +
Sbjct: 1713 LTKEHLMLEEELRNLRLEYDDLRRGRSEADSD--KNATILELRSQLQISNNRTLELQGLI 1770
Query: 405 KQLKEEKK-VRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAIN 463
L+ E++ +R E+EK + + ++ + + E++ LV ++ LE+ KA
Sbjct: 1771 NDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKV-LEQDKARL 1829
Query: 464 LQMFHKAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAE---ERSH 520
++ + A+S+L+ + E + Q+ + + Q + + E A + E E+S
Sbjct: 1830 QRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSE 1889
Query: 521 KLQQELGGRIGALQLQLSQLHEQC-SSLEKELKSEKEQRQALQRELQHEKD 570
+ + L I LQ ++ ++ E+C LE + + Q + + Q E D
Sbjct: 1890 REKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREID 1940
Score = 54.7 bits (130), Expect = 3e-07
Identities = 81/385 (21%), Positives = 162/385 (42%), Gaps = 53/385 (13%)
Query: 286 LKDVQDLDGGKEHERITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSA 345
LK +LDG + + Q ++ELN ++ L +I+ ++ +++
Sbjct: 1082 LKRQAELDGKSAKQNLDKCYGQ---IKELNEKIT----RLTYEIEDEKRRRKSVEDRFDQ 1134
Query: 346 ATDRICSLQEEQQQLREQNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWK 405
+ LQ+ +Q +E + SEK+++ + + E+E + R L E + +
Sbjct: 1135 QKNDYDQLQKARQCEKENLGWQKLESEKAIK----EKEYEIE---RLRVLLQEEGTRKRE 1187
Query: 406 QLKEEKKVRLELEKELE-LQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAIN- 463
E KVR +E+ L+ +TE+ I +++ + +K+D LR QL+ + N
Sbjct: 1188 YENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENR 1247
Query: 464 -------------LQMFHKAQNAESSLQQKNEAITSFEGKTNQVMSSMKQ-MEERLQHSE 509
LQ + + AE + Q+ + K + +KQ M++R + +
Sbjct: 1248 DLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNA 1307
Query: 510 RARQGAEERSHKLQ-------------QELGGRIGALQLQLSQLH----EQCSSLEKELK 552
R +Q EE + +Q QE R + +LS++ E+ SL+ + +
Sbjct: 1308 RHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFE 1367
Query: 553 SEKEQRQAL--QRELQHEKDTSSLLRMELQQVEGLKKELRELQDEKAELQKICEEQEQAL 610
+E + Q +Q E+DTS Q++ L +E R L +E L+ + + L
Sbjct: 1368 TEINITKTTIHQLTMQKEEDTSGY----RAQIDNLTRENRSLSEEIKRLKNTLTQTTENL 1423
Query: 611 QEMGLHLSQSKLKMEDIKEVNQALK 635
+ + + Q K ++ + Q L+
Sbjct: 1424 RRVEEDIQQQKATGSEVSQRKQQLE 1448
Score = 44.7 bits (104), Expect = 3e-04
Identities = 73/401 (18%), Positives = 174/401 (43%), Gaps = 56/401 (13%)
Query: 291 DLDGGKEHERITDVLDQKNYVEELNRHLSCTVGDLQTKIDGL-----------------E 333
DLD GK E++T + D+ + +++ + + DL+ +I L +
Sbjct: 850 DLDLGKFGEKVTQLTDRW---QRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAK 906
Query: 334 KTNSKLQEELSAATDRICSLQEEQQQLREQNELIRERSEKSVEITK------QDTKVELE 387
+ L+ ++ + EQ+ L + R++SE+ +I + +D +++L
Sbjct: 907 RRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLA 966
Query: 388 TYKQTRQGLDEMYSDVWKQLKEEKKVRLELEKELELQ---IGMKTE-------MEIAMKL 437
+Y GL+ + + K+ + + L++ ++ I + T + +K
Sbjct: 967 SYTS---GLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKS 1023
Query: 438 LEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQKNEAITSFEGKTNQVMSS 497
LE D K + L ++L + N + +K + + +LQ+ + F+ K ++S
Sbjct: 1024 LE-DLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAK----LAS 1078
Query: 498 MKQMEERLQHSERARQGAEERSHKLQQELGGRIGALQLQLSQLHEQCSSLEKELKSEKEQ 557
+++++ + + ++ + ++ + +EL +I L ++ + S+E +K
Sbjct: 1079 LEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKND 1138
Query: 558 RQALQRELQHEKDTSSLLRME----LQQVEGLKKELRELQDEKAELQKICEEQEQALQEM 613
LQ+ Q EK+ ++E +++ E + LR L E+ ++ E E L ++
Sbjct: 1139 YDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKR---EYENELAKV 1195
Query: 614 GLHLSQ--SKLKMEDIKEVN---QALKGHAWLKDDEATHCR 649
H ++ S L+ + E+N +K + K+D++ + R
Sbjct: 1196 RNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLR 1236
Score = 33.1 bits (74), Expect = 0.91
Identities = 65/335 (19%), Positives = 140/335 (41%), Gaps = 60/335 (17%)
Query: 329 IDGLEKTNSKLQEELSAATDRICSLQEEQQQLREQNELIRERSEKSV------------- 375
+D L + ++ + A R+ LQE+ + L + + R R S
Sbjct: 121 LDSLIREMRQMGQPCDAYQKRLLQLQEQMRALYKAISVPRVRRASSKGGGGYTCQSGSGW 180
Query: 376 -EITKQDTKVELETYKQTRQGLDEM-----YSDVWKQLKEEKKV-------RLELEKELE 422
E TK T L +Q R +D + + V + + + + R +L+K ++
Sbjct: 181 DEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDK-IK 239
Query: 423 LQIGMKT---EMEIAMKLLEKDTHEKQDTLVALRQQLE----EVKAIN----LQMFHKAQ 471
+ K+ ++E + L K + E+ D L L+ ++ E+ IN ++ +
Sbjct: 240 ADLREKSAIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDWS 299
Query: 472 NAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGGRIG 531
+ +++ QK EA F + +Q+ K++ + Q S++ S K++ +
Sbjct: 300 DKNTNIAQKQEA---FSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMD---- 352
Query: 532 ALQLQLSQLHEQCSSLEKELKS---------EKEQRQALQRELQ------HEKDTSSLLR 576
LQ Q S + + ++ LK E + +A + LQ + D + L+
Sbjct: 353 TLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQ 412
Query: 577 MELQQVEGLKKELRELQDEKAELQKICEEQEQALQ 611
L+Q++ L+KE ++ + K ++Q + + ++ +Q
Sbjct: 413 HLLEQIKELEKEREKILEYKRQVQNLVNKSKKIVQ 447
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 91.7 bits (226), Expect = 2e-18
Identities = 70/357 (19%), Positives = 171/357 (47%), Gaps = 28/357 (7%)
Query: 307 QKNYVEELNRHLSCTVGDL--------QTKIDGLEKTNSKLQEELSAATDRICSLQEEQQ 358
Q +E+ N HL+ TV L + ++ +EK N L E + + ++ ++ E++
Sbjct: 552 QIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKR 611
Query: 359 QLREQNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLKEEKKVRLELE 418
Q++++ E +E+ E++ E+ + +E E ++ + + + E++ LE E
Sbjct: 612 QIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERE 671
Query: 419 -KELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQNAESSL 477
++L+ + + ++ LEK+ + + + LR+ +E +K +++M + L
Sbjct: 672 NRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKM--------AQL 723
Query: 478 QQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGGRIGALQLQL 537
Q +N+ + S + + + + +K ++ + E + QG + + +LQ+ L
Sbjct: 724 QLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTL----------- 772
Query: 538 SQLHEQCSSLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKELRELQDEKA 597
+++ LE EL+ + + Q LQ+ L+ K +S L ++ + L++E +L+ +K
Sbjct: 773 ENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKK 832
Query: 598 ELQKICEEQEQALQEMGLHLSQSKLKMEDIKEVNQALKGHAWLKDDEATHCRQCEKE 654
+L+K + Q + L ++ +K+ ++++ N+ L + + ++ EKE
Sbjct: 833 QLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKE 889
Score = 67.0 bits (162), Expect = 6e-11
Identities = 87/363 (23%), Positives = 153/363 (42%), Gaps = 74/363 (20%)
Query: 325 LQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQLREQNELIRERSEKSVEITKQDTKV 384
L+ GL+ N +LQ+ L + +I L+ E Q L +N+ +++ E+ +K+ ++
Sbjct: 754 LEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQL 813
Query: 385 ELETYKQTRQGLDEMYSDVWKQLKEEKKVRLELE--------------------KELELQ 424
E E K Q ++ D + KE K++R + E K L +
Sbjct: 814 EKEN-KSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKE 872
Query: 425 IGMKTEMEIAMKLLEKDTHE-------KQDTLVALRQQLEEVKAINLQMFHKAQNAESSL 477
IG+ E + +K LEK+ E TLV LR+ L K K Q + L
Sbjct: 873 IGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKL-------KTQQMNNDL 925
Query: 478 QQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGGRIGALQLQL 537
+ K + + +ERL H E Q ++ +KL L+ +L
Sbjct: 926 E-----------KLTHELEKIGLNKERLLHDE---QSTDDSRYKL----------LESKL 961
Query: 538 SQLHEQCSSLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKELRELQDEKA 597
S+L+K L+ ++E+ AL+ L+ + + LR EL+ V+ + L++ QDE+
Sbjct: 962 E------STLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEER 1015
Query: 598 ELQK---ICEEQ---EQALQEMGLHLSQSKLKMEDIKEVNQALKGHAWLKDDEATHCRQC 651
+Q I E E+ QE L + K ++ +++ N L+ K T +Q
Sbjct: 1016 MVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAE---KQALKTQLKQL 1072
Query: 652 EKE 654
E +
Sbjct: 1073 ETQ 1075
Score = 65.9 bits (159), Expect = 1e-10
Identities = 96/480 (20%), Positives = 206/480 (42%), Gaps = 67/480 (13%)
Query: 185 PEASDIATSVRNLPELKTAVGRGRAWLYLA-------LMQKKLADYLKVLIDNKHLLSEF 237
P AS A S P +K R + LA ++++L + + L+D K L +
Sbjct: 225 PHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQM 284
Query: 238 YEPEALMMEEEGMVIVGLLVGLNVLDANLCLKGEDLDSQVGVIDFSLYLKDVQDLDGGKE 297
E E +++E M ++ DA D ++ + D + + +
Sbjct: 285 -EIELKRLQQENMNLLS--------DARSARMYRD---ELDALREKAVRVDKLESEVSRY 332
Query: 298 HERITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELS---AATDRICSLQ 354
ER+ D+ K VEEL D Q ++ T + L+++L A +D++ L+
Sbjct: 333 KERLHDIEFYKARVEELKE-------DNQVLLE----TKTMLEDQLEGTRARSDKLHELE 381
Query: 355 EEQQQLREQ---NELIRERSEKSVE-ITKQDTKVELETYKQTRQGLDEMYSDVWK--QLK 408
+E QL+ + E+ R+ K +E + +++ +E+ +Q +DE W+ Q+
Sbjct: 382 KENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQ----KQSMDESLHLGWELEQIS 437
Query: 409 EEKKVRLELEKEL-----ELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAI- 462
++ +K L EL ++E+ + L K E + T+ ++ ++ +
Sbjct: 438 RTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKME 497
Query: 463 --NLQMFHKAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQ----HSERARQGAE 516
N ++ K + E+ + Q+ +++ + + + +M Q+E+ ++ +SER + E
Sbjct: 498 KENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILE 557
Query: 517 ERSHKLQQELGG-----------RIGALQLQLSQLHEQCSSLEKELKSEKEQRQALQREL 565
+ + L Q + R+ ++ + LHE +L + +++ +++EL
Sbjct: 558 QENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKEL 617
Query: 566 QHEKDTSSLLRMELQQVEGLKKELRELQDEKAELQKICEEQEQALQEMGLHLSQSKLKME 625
+H K+ ++ L+KE LQ + L+ CE+ E AL++ L + K++
Sbjct: 618 EHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIE-ALEQENSELERENRKLK 676
Score = 45.4 bits (106), Expect = 2e-04
Identities = 65/308 (21%), Positives = 122/308 (39%), Gaps = 48/308 (15%)
Query: 325 LQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQLREQNE-LIRERSE-KSV--EITKQ 380
LQT+ L+ NS L + ++ ++ L +Q L +NE +I+ER + KS+ + K
Sbjct: 1100 LQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKD 1159
Query: 381 DTKVELETYKQTRQGLDEMYSDVWKQLKEEKKVRLELEKELELQIGMKTEMEIAMKLLEK 440
K+EL L E + ++ L + K LE++ +
Sbjct: 1160 HEKLEL---------LHERQASEYESLISKHGTLKSAHKNLEVE--------------HR 1196
Query: 441 DTHEKQDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQKNEAITSFEGK--------TN 492
D ++ + L+ + QLE+ L+ K + + L+ KN + E K N
Sbjct: 1197 DLEDRYNQLLKQKGQLED-----LEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLN 1251
Query: 493 QVMSSMKQMEERLQHSERARQGAEERSHKLQQELGGRIGALQLQLSQLHEQCSSLEKELK 552
S + + E LQ + + S Q L L+ Q QL + L + +
Sbjct: 1252 HTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCE 1311
Query: 553 SEKEQRQALQRELQHEKD--------TSSLLRMELQQVEGLKKELRELQDEKAELQKICE 604
+ + L+ E +H D +LL ++ + E R+ D+ EL++ E
Sbjct: 1312 LLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKE 1371
Query: 605 EQEQALQE 612
+ E+ + +
Sbjct: 1372 KLEEKIMD 1379
Score = 40.0 bits (92), Expect = 0.007
Identities = 37/183 (20%), Positives = 80/183 (43%), Gaps = 17/183 (9%)
Query: 469 KAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEER----LQHSERARQGAEERSHKLQQ 524
K + L++K E + + + Q+ +K++++ L + AR +E +
Sbjct: 259 KIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELD--ALR 316
Query: 525 ELGGRIGALQLQLSQLHEQCSSLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEG 584
E R+ L+ ++S+ E+ +E K + + L+ + Q +T ++L +L+
Sbjct: 317 EKAVRVDKLESEVSRYKERLHDIE----FYKARVEELKEDNQVLLETKTMLEDQLEGTRA 372
Query: 585 LKKELRELQDEKAELQKICEEQEQALQEMGLHLSQSKLKMEDIKEVNQALKGHAWLKDDE 644
+L EL+ E +L+ L +M + + K+E++ E N L+ DE
Sbjct: 373 RSDKLHELEKENLQLKA-------KLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDE 425
Query: 645 ATH 647
+ H
Sbjct: 426 SLH 428
Score = 30.0 bits (66), Expect = 7.7
Identities = 35/150 (23%), Positives = 67/150 (44%), Gaps = 16/150 (10%)
Query: 311 VEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQLREQN----EL 366
++E + L T L + + L + L+EE D+I +L + + L EQN +L
Sbjct: 1292 LKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDL 1351
Query: 367 I----RERSEKSVEITKQDTKVE---LETYK-----QTRQGLDEMYSDVWKQLKEEKKVR 414
R+ +K E+ +Q K+E ++ YK R+ + + + K +K +K +
Sbjct: 1352 FHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDIN 1411
Query: 415 LELEKELELQIGMKTEMEIAMKLLEKDTHE 444
E +K L L E ++L +D+ +
Sbjct: 1412 RERQKSLTLTPTRSDSSEGFLQLPHQDSQD 1441
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 91.7 bits (226), Expect = 2e-18
Identities = 70/357 (19%), Positives = 171/357 (47%), Gaps = 28/357 (7%)
Query: 307 QKNYVEELNRHLSCTVGDL--------QTKIDGLEKTNSKLQEELSAATDRICSLQEEQQ 358
Q +E+ N HL+ TV L + ++ +EK N L E + + ++ ++ E++
Sbjct: 552 QIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKR 611
Query: 359 QLREQNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLKEEKKVRLELE 418
Q++++ E +E+ E++ E+ + +E E ++ + + + E++ LE E
Sbjct: 612 QIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERE 671
Query: 419 -KELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQNAESSL 477
++L+ + + ++ LEK+ + + + LR+ +E +K +++M + L
Sbjct: 672 NRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKM--------AQL 723
Query: 478 QQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGGRIGALQLQL 537
Q +N+ + S + + + + +K ++ + E + QG + + +LQ+ L
Sbjct: 724 QLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTL----------- 772
Query: 538 SQLHEQCSSLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKELRELQDEKA 597
+++ LE EL+ + + Q LQ+ L+ K +S L ++ + L++E +L+ +K
Sbjct: 773 ENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKK 832
Query: 598 ELQKICEEQEQALQEMGLHLSQSKLKMEDIKEVNQALKGHAWLKDDEATHCRQCEKE 654
+L+K + Q + L ++ +K+ ++++ N+ L + + ++ EKE
Sbjct: 833 QLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKE 889
Score = 67.4 bits (163), Expect = 4e-11
Identities = 86/363 (23%), Positives = 151/363 (41%), Gaps = 75/363 (20%)
Query: 325 LQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQLREQNELIRERSEKSVEITKQDTKV 384
L+ GL+ N +LQ+ L + +I L+ E Q L +N+ +++ E+ +K+ ++
Sbjct: 754 LEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQL 813
Query: 385 ELETYKQTRQGLDEMYSDVWKQLKEEKKVRLELE--------------------KELELQ 424
E E K Q ++ D + KE K++R + E K L +
Sbjct: 814 EKEN-KSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKE 872
Query: 425 IGMKTEMEIAMKLLEKDTHE-------KQDTLVALRQQLEEVKAINLQMFHKAQNAESSL 477
IG+ E + +K LEK+ E TLV LR+ L K K Q + L
Sbjct: 873 IGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKL-------KTQQMNNDL 925
Query: 478 QQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGGRIGALQLQL 537
+ K + + +ERL H E Q ++R L+ +L
Sbjct: 926 E-----------KLTHELEKIGLNKERLLHDE---QSTDDRYKLLESKLE---------- 961
Query: 538 SQLHEQCSSLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKELRELQDEKA 597
S+L+K L+ ++E+ AL+ L+ + + LR EL+ V+ + L++ QDE+
Sbjct: 962 -------STLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEER 1014
Query: 598 ELQK---ICEEQ---EQALQEMGLHLSQSKLKMEDIKEVNQALKGHAWLKDDEATHCRQC 651
+Q I E E+ QE L + K ++ +++ N L+ K T +Q
Sbjct: 1015 MVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAE---KQALKTQLKQL 1071
Query: 652 EKE 654
E +
Sbjct: 1072 ETQ 1074
Score = 65.9 bits (159), Expect = 1e-10
Identities = 96/480 (20%), Positives = 206/480 (42%), Gaps = 67/480 (13%)
Query: 185 PEASDIATSVRNLPELKTAVGRGRAWLYLA-------LMQKKLADYLKVLIDNKHLLSEF 237
P AS A S P +K R + LA ++++L + + L+D K L +
Sbjct: 225 PHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQM 284
Query: 238 YEPEALMMEEEGMVIVGLLVGLNVLDANLCLKGEDLDSQVGVIDFSLYLKDVQDLDGGKE 297
E E +++E M ++ DA D ++ + D + + +
Sbjct: 285 -EIELKRLQQENMNLLS--------DARSARMYRD---ELDALREKAVRVDKLESEVSRY 332
Query: 298 HERITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELS---AATDRICSLQ 354
ER+ D+ K VEEL D Q ++ T + L+++L A +D++ L+
Sbjct: 333 KERLHDIEFYKARVEELKE-------DNQVLLE----TKTMLEDQLEGTRARSDKLHELE 381
Query: 355 EEQQQLREQ---NELIRERSEKSVE-ITKQDTKVELETYKQTRQGLDEMYSDVWK--QLK 408
+E QL+ + E+ R+ K +E + +++ +E+ +Q +DE W+ Q+
Sbjct: 382 KENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQ----KQSMDESLHLGWELEQIS 437
Query: 409 EEKKVRLELEKEL-----ELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAI- 462
++ +K L EL ++E+ + L K E + T+ ++ ++ +
Sbjct: 438 RTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKME 497
Query: 463 --NLQMFHKAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQ----HSERARQGAE 516
N ++ K + E+ + Q+ +++ + + + +M Q+E+ ++ +SER + E
Sbjct: 498 KENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILE 557
Query: 517 ERSHKLQQELGG-----------RIGALQLQLSQLHEQCSSLEKELKSEKEQRQALQREL 565
+ + L Q + R+ ++ + LHE +L + +++ +++EL
Sbjct: 558 QENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKEL 617
Query: 566 QHEKDTSSLLRMELQQVEGLKKELRELQDEKAELQKICEEQEQALQEMGLHLSQSKLKME 625
+H K+ ++ L+KE LQ + L+ CE+ E AL++ L + K++
Sbjct: 618 EHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIE-ALEQENSELERENRKLK 676
Score = 45.4 bits (106), Expect = 2e-04
Identities = 65/308 (21%), Positives = 122/308 (39%), Gaps = 48/308 (15%)
Query: 325 LQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQLREQNE-LIRERSE-KSV--EITKQ 380
LQT+ L+ NS L + ++ ++ L +Q L +NE +I+ER + KS+ + K
Sbjct: 1099 LQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKD 1158
Query: 381 DTKVELETYKQTRQGLDEMYSDVWKQLKEEKKVRLELEKELELQIGMKTEMEIAMKLLEK 440
K+EL L E + ++ L + K LE++ +
Sbjct: 1159 HEKLEL---------LHERQASEYESLISKHGTLKSAHKNLEVE--------------HR 1195
Query: 441 DTHEKQDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQKNEAITSFEGK--------TN 492
D ++ + L+ + QLE+ L+ K + + L+ KN + E K N
Sbjct: 1196 DLEDRYNQLLKQKGQLED-----LEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLN 1250
Query: 493 QVMSSMKQMEERLQHSERARQGAEERSHKLQQELGGRIGALQLQLSQLHEQCSSLEKELK 552
S + + E LQ + + S Q L L+ Q QL + L + +
Sbjct: 1251 HTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCE 1310
Query: 553 SEKEQRQALQRELQHEKD--------TSSLLRMELQQVEGLKKELRELQDEKAELQKICE 604
+ + L+ E +H D +LL ++ + E R+ D+ EL++ E
Sbjct: 1311 LLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKE 1370
Query: 605 EQEQALQE 612
+ E+ + +
Sbjct: 1371 KLEEKIMD 1378
Score = 40.0 bits (92), Expect = 0.007
Identities = 37/183 (20%), Positives = 80/183 (43%), Gaps = 17/183 (9%)
Query: 469 KAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEER----LQHSERARQGAEERSHKLQQ 524
K + L++K E + + + Q+ +K++++ L + AR +E +
Sbjct: 259 KIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELD--ALR 316
Query: 525 ELGGRIGALQLQLSQLHEQCSSLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEG 584
E R+ L+ ++S+ E+ +E K + + L+ + Q +T ++L +L+
Sbjct: 317 EKAVRVDKLESEVSRYKERLHDIE----FYKARVEELKEDNQVLLETKTMLEDQLEGTRA 372
Query: 585 LKKELRELQDEKAELQKICEEQEQALQEMGLHLSQSKLKMEDIKEVNQALKGHAWLKDDE 644
+L EL+ E +L+ L +M + + K+E++ E N L+ DE
Sbjct: 373 RSDKLHELEKENLQLKA-------KLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDE 425
Query: 645 ATH 647
+ H
Sbjct: 426 SLH 428
Score = 30.0 bits (66), Expect = 7.7
Identities = 35/150 (23%), Positives = 67/150 (44%), Gaps = 16/150 (10%)
Query: 311 VEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQLREQN----EL 366
++E + L T L + + L + L+EE D+I +L + + L EQN +L
Sbjct: 1291 LKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDL 1350
Query: 367 I----RERSEKSVEITKQDTKVE---LETYK-----QTRQGLDEMYSDVWKQLKEEKKVR 414
R+ +K E+ +Q K+E ++ YK R+ + + + K +K +K +
Sbjct: 1351 FHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDIN 1410
Query: 415 LELEKELELQIGMKTEMEIAMKLLEKDTHE 444
E +K L L E ++L +D+ +
Sbjct: 1411 RERQKSLTLTPTRSDSSEGFLQLPHQDSQD 1440
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 87.8 bits (216), Expect = 3e-17
Identities = 92/356 (25%), Positives = 162/356 (45%), Gaps = 43/356 (12%)
Query: 296 KEHERITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICSLQE 355
+E ++ ++ + +E + LS + +LQ +I L+ +K +EEL AA R+ +E
Sbjct: 1038 REEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARV---EE 1094
Query: 356 EQQQLREQNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLKEEKKVRL 415
E Q + IRE + E+ + +LE+ + +R ++ D+ ++L+ ++
Sbjct: 1095 EAAQKNMALKKIRELESQISELQE-----DLESERASRNKAEKQKRDLGEELEA---LKT 1146
Query: 416 ELEKEL-------ELQIGMKTEMEIAMKLLEKD--THEKQ---------DTLVALRQQLE 457
ELE L EL+ + E+ I K LE++ THE Q + L +QLE
Sbjct: 1147 ELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLE 1206
Query: 458 EVKAINLQMFHKAQNAESSLQQ-KNEAITSFEGKTN------QVMSSMKQMEERLQHSER 510
+ K + + Q E+ + NE +GK + +V + +++++ + ER
Sbjct: 1207 QTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGER 1266
Query: 511 ARQGAEERSHKLQQELGGRIGALQLQLSQLHEQCSSLEKELKSEKEQRQALQRELQHEKD 570
R ++ KLQ EL G L SQ + S L K+ + + Q Q Q LQ E
Sbjct: 1267 VRTELADKVTKLQVELDNVTGLL----SQSDSKSSKLTKDFSALESQLQDTQELLQEENR 1322
Query: 571 TSSLLRMELQQVEGLKKELRELQDEKAELQKICEEQEQALQEMGLHLSQSKLKMED 626
L +L+QVE K RE +E+ E + E+Q + + ++ K KMED
Sbjct: 1323 QKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQ---IATLHAQVADMKKKMED 1375
Score = 84.3 bits (207), Expect = 3e-16
Identities = 112/502 (22%), Positives = 225/502 (44%), Gaps = 83/502 (16%)
Query: 167 IGQNKSFF--GPLELVE-----KLCPEASDIATSVRNLPELKTAVGRGRAWLYLALMQKK 219
IGQ+K FF G L +E K+ R K R + + ++Q+
Sbjct: 756 IGQSKVFFRAGVLAHLEEERDLKITDVIIGFQACCRGYLARKAFAKRQQQLTAMKVLQRN 815
Query: 220 LADYLKV--------LIDNKHLLSEFYEPEALMMEEEGMVIV--------GLLVGLNVLD 263
A YLK+ K LL + E +M +EE +V V L + L
Sbjct: 816 CAAYLKLRNWQWWRLFTKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQ 875
Query: 264 ANLCLKGEDLDSQVGV-IDFSLYLKDVQDLDGGKEHE----------RITDVLDQKNYVE 312
+ L + L Q+ + ++++ K+ E R+ + ++ +++
Sbjct: 876 SQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQ 935
Query: 313 ELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQLREQN-------E 365
+ + + +L+ +++ E KLQ E ++ L+EEQ L +QN +
Sbjct: 936 AEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKK 995
Query: 366 LIRER-SEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLKEEKKVRLELEKELELQ 424
L+ +R +E + +T+++ K ++ + + + M +D+ ++L+ E+K R ELEK
Sbjct: 996 LLEDRIAEFTTNLTEEEEK--SKSLAKLKNKHEAMITDLEERLRREEKQRQELEK----- 1048
Query: 425 IGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQNAESSL------- 477
+ LE D+ + D + L+ Q+ E+K +Q+ K + +++L
Sbjct: 1049 ---------TRRKLEGDSTDLSDQIAELQAQIAELK---MQLAKKEEELQAALARVEEEA 1096
Query: 478 QQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGGRIGALQLQL 537
QKN A+ K ++ S + +++E L+ SERA + ++ K +++LG + AL+ +L
Sbjct: 1097 AQKNMALK----KIRELESQISELQEDLE-SERA---SRNKAEKQKRDLGEELEALKTEL 1148
Query: 538 SQLHEQCSSLEKELKSEKEQ-----RQALQRELQ-HEKDTSSLLRMELQQVEGLKKELRE 591
+ ++ ++EL+S++EQ ++ L+ E + HE + + Q VE L ++L +
Sbjct: 1149 EDTLDS-TAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQ 1207
Query: 592 LQDEKAELQKICEEQEQALQEM 613
+ KA L+K + E E+
Sbjct: 1208 TKRVKANLEKAKQTLENERGEL 1229
Score = 70.9 bits (172), Expect = 4e-12
Identities = 68/357 (19%), Positives = 157/357 (43%), Gaps = 49/357 (13%)
Query: 301 ITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQL 360
+ + ++QK +E LN+ + DL + D + K+ +L++ A ++ ++ + ++L
Sbjct: 1485 LEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEEL 1544
Query: 361 REQNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLKEEKKVRLELEKE 420
++ + E ++ +E+ Q K + E + QG DE + KQL + + E+E E
Sbjct: 1545 EDELQAT-EDAKLRLEVNLQAMKAQFE---RDLQGRDEQSEEKKKQLVRQVR---EMEAE 1597
Query: 421 LELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQK 480
LE D +++ VA R++LE + + + +S+ + +
Sbjct: 1598 LE------------------DERKQRSMAVAARKKLE------MDLKDLEAHIDSANKNR 1633
Query: 481 NEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGGRIGALQLQLSQL 540
+EAI Q+ M+++++ E A+E KL+ +++ ++ QL
Sbjct: 1634 DEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLK--------SMEAEMIQL 1685
Query: 541 HEQCSSLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKELRELQDEKAELQ 600
E+ ++ E+ + +++R L E+ + +L +E R L+ A+L+
Sbjct: 1686 QEELAAAERAKRQAQQERDELADEIANSSGKGALAL----------EEKRRLEARIAQLE 1735
Query: 601 KICEEQEQALQEMGLHLSQSKLKMEDIKEVNQALKGHAWLKDDEATHCRQCEKEFSI 657
+ EE++ + + L ++ L+++ I + HA ++ + KE +
Sbjct: 1736 EELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKV 1792
Score = 66.2 bits (160), Expect = 1e-10
Identities = 99/478 (20%), Positives = 205/478 (42%), Gaps = 53/478 (11%)
Query: 213 LALMQKKLADYLKVLIDNKHLLSEFYEPEALMMEEEGMVIVGLLVGLNVLDANLCLKGED 272
+A +Q ++A+ LK+ + K E + +EEE L + L++ + ED
Sbjct: 1064 IAELQAQIAE-LKMQLAKKE---EELQAALARVEEEAAQKNMALKKIRELESQISELQED 1119
Query: 273 LDSQVGVIDFSLYLKDVQDLDGGKEHE----RITDVLDQKNYVEELNRHLSCTVGDLQTK 328
L+S+ S + Q D G+E E + D LD +EL V L+
Sbjct: 1120 LESERA----SRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKT 1175
Query: 329 IDGLEKTNS----KLQEELSAATDRICSLQEEQQQLREQNELIRERSEKSVEITKQDTKV 384
++ KT+ +++++ S A + + E+ ++++ E ++ E + KV
Sbjct: 1176 LEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKV 1235
Query: 385 ELE---TYKQTRQGLDEMYSDVWKQLKEEKKVRLEL-EKELELQI------GMKTEMEIA 434
L+ + R+ ++ ++ + E ++VR EL +K +LQ+ G+ ++ +
Sbjct: 1236 LLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSK 1295
Query: 435 MKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQNAESS-------LQQKNEAITSF 487
L KD + L ++ L+E L + K + E L+++ EA +
Sbjct: 1296 SSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNL 1355
Query: 488 EGKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGGRIGALQLQLSQLHEQ---- 543
E + + + + M+++++ S + AEE KLQ++L G LSQ HE+
Sbjct: 1356 EKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEG--------LSQRHEEKVAA 1407
Query: 544 CSSLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKELRELQDEKAELQKIC 603
LEK +++ L +L H++ ++ L + ++ + L E + + + AE +
Sbjct: 1408 YDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRA 1467
Query: 604 EEQEQALQEMGLHLS-------QSKLKMEDI-KEVNQALKGHAWLKDDEATHCRQCEK 653
E + + + L L+ + K ++E + K+ ++ KDD + EK
Sbjct: 1468 EAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEK 1525
Score = 64.7 bits (156), Expect = 3e-10
Identities = 87/423 (20%), Positives = 180/423 (42%), Gaps = 65/423 (15%)
Query: 294 GGKEHER------ITDVLDQKNYVEELNRHLSCTVGDLQTKIDGL-------EKTNSKLQ 340
G EH+R + ++ + N E + L+ V LQ ++D + + +SKL
Sbjct: 1241 GDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLT 1300
Query: 341 EELSAATDRICSLQEEQQQLREQN--ELIRERSEKSVEITKQDTKVELETYKQTRQGLDE 398
++ SA + LQ+ Q+ L+E+N +L K VE K + +LE ++ + L++
Sbjct: 1301 KDFSALESQ---LQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEK 1357
Query: 399 MYSDVWKQLKEEKK--------------VRLELEKELELQIGMKTEMEIAMKLLEKDTHE 444
+ + Q+ + KK V+ +L+K+LE E A LEK
Sbjct: 1358 QIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTR 1417
Query: 445 KQDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEER 504
Q L L L+ + + K + + L ++ + + ++ + ++ E +
Sbjct: 1418 LQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETK 1477
Query: 505 LQHSERARQGAEERSHKLQ----------QELGGRIGALQLQLSQLHEQCSSLEKELKSE 554
RA + A E+ +L+ ++L + + +L + +LE++++
Sbjct: 1478 ALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEM 1537
Query: 555 KEQRQALQRELQHEKDTSSLLRMELQ---------------QVEGLKKEL-RELQDEKAE 598
K Q + L+ ELQ +D L + LQ Q E KK+L R++++ +AE
Sbjct: 1538 KTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAE 1597
Query: 599 LQKICEEQEQALQEMGLHLSQSKLKMEDIKEVNQALKGHAWLKDDEATHCRQCEKEFSIS 658
L+ +++ A+ ++ KL+M D+K++ + +D+ R+ + +
Sbjct: 1598 LEDERKQRSMAV------AARKKLEM-DLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDC 1650
Query: 659 RRK 661
R+
Sbjct: 1651 MRE 1653
Score = 62.4 bits (150), Expect = 1e-09
Identities = 67/348 (19%), Positives = 149/348 (42%), Gaps = 56/348 (16%)
Query: 286 LKDVQDLDGGKEHERITDVLDQKNYVEELNRHLSCTVGDLQTKIDG-----------LEK 334
++ V++++ E ER Q++ + L + DL+ ID L K
Sbjct: 1588 VRQVREMEAELEDER-----KQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRK 1642
Query: 335 TNSKLQEELSAATDRICSLQEEQQQLREQNELIRERSEKSVEITKQDTKVELETYKQTRQ 394
+++++ + D S +E Q +E + ++ + +++ ++ E +Q +Q
Sbjct: 1643 LQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAE-RAKRQAQQ 1701
Query: 395 GLDEMYSDVWKQLKEEKKVRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQ 454
DE+ ++ + + LE ++ LE +I ++E ++ + +T D L
Sbjct: 1702 ERDELADEIANS-SGKGALALEEKRRLEARIA---QLEEELEEEQGNTELINDRLKKANL 1757
Query: 455 QLEEVKA-INLQMFH--KAQNAESSLQQKNEAI------------TSFEGKTNQVMSSMK 499
Q++++ +NL+ H K +NA L+++N+ + + ++ + + +
Sbjct: 1758 QIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIA 1817
Query: 500 QMEERLQHSERARQGAEERSHKLQQELGG-----------------RIGALQLQLSQLHE 542
Q+EE+L + + RQ A ++ + +++L + +L QL
Sbjct: 1818 QLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKR 1877
Query: 543 QCSSLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKELR 590
Q E+E + R+ LQREL+ +T+ + E V LK +LR
Sbjct: 1878 QLEEAEEEAQRANASRRKLQRELEDATETADAMNRE---VSSLKNKLR 1922
Score = 61.2 bits (147), Expect = 3e-09
Identities = 70/311 (22%), Positives = 143/311 (45%), Gaps = 28/311 (9%)
Query: 325 LQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQLREQNELIRERSEKSVEITKQDTKV 384
L TK+ L + S+ +EE+ A + + ++E+Q L +N L + +S + + K+
Sbjct: 830 LFTKVKPLLQV-SRQEEEMMAKEEELVKVREKQ--LAAENRLTEMETLQSQLMAE---KL 883
Query: 385 ELETYKQTRQGLDEMYSDVWKQLKEEKKVRLELEKELELQIGMKTEMEIAMKLLEKDTHE 444
+L+ Q L ++ +L +K+ E+ +LE ++ E E + L+ + +
Sbjct: 884 QLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARV---EEEEERCQHLQAEKKK 940
Query: 445 KQDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEER 504
Q + L +QLEE ++ ++ + E+ L++ E E + ++ K +E+R
Sbjct: 941 MQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDR 1000
Query: 505 LQHSERARQGAEERSHKLQQELGGRIGALQLQLSQLHE-QCSSLEKELKSEKEQRQALQR 563
+ EE+S L + L HE + LE+ L+ E++QRQ L++
Sbjct: 1001 IAEFTTNLTEEEEKSKSLAK------------LKNKHEAMITDLEERLRREEKQRQELEK 1048
Query: 564 ELQHEKDTSSLLRMELQQVEGLKKELRELQDEKAELQKICEEQEQALQEMGLHLSQSKLK 623
+ + S+ L Q+ L+ ++ EL K +L K EE + AL + +Q +
Sbjct: 1049 TRRKLEGDSTDLS---DQIAELQAQIAEL---KMQLAKKEEELQAALARVEEEAAQKNMA 1102
Query: 624 MEDIKEVNQAL 634
++ I+E+ +
Sbjct: 1103 LKKIRELESQI 1113
Score = 57.4 bits (137), Expect = 5e-08
Identities = 57/226 (25%), Positives = 106/226 (46%), Gaps = 15/226 (6%)
Query: 445 KQDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEER 504
K L+ + +Q EE+ A ++ + E L +N +T E +Q+M+ Q++E+
Sbjct: 833 KVKPLLQVSRQEEEMMAKEEEL---VKVREKQLAAENR-LTEMETLQSQLMAEKLQLQEQ 888
Query: 505 LQHSERARQGAEERSHKL---QQELGGRIGALQLQLSQLHEQCSSLEKELKSEKEQRQAL 561
LQ AEE +L +QEL L+ ++ + E+C L+ E K ++ Q L
Sbjct: 889 LQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQEL 948
Query: 562 QRELQHEKDTSSLLRMELQQVEGLKKELRE----LQDEKAELQKICEEQEQALQEMGLHL 617
+ +L+ E+ L++E E K+L E L+D+ +L K + E + E +L
Sbjct: 949 EEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNL 1008
Query: 618 SQSKLKMEDIKEVNQALKGHAWLKDDEATHCRQ--CEKEFSISRRK 661
++ + K + + ++ K A + D E R+ +E +RRK
Sbjct: 1009 TEEEEKSKSLAKLKN--KHEAMITDLEERLRREEKQRQELEKTRRK 1052
Score = 54.7 bits (130), Expect = 3e-07
Identities = 61/270 (22%), Positives = 117/270 (43%), Gaps = 26/270 (9%)
Query: 408 KEEKKVRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMF 467
KEE+ V++ EK+L + + TEME L + + Q+ L A + E + + ++
Sbjct: 850 KEEELVKVR-EKQLAAENRL-TEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLT 907
Query: 468 HKAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQE-- 525
K Q E + E + + + K+M++ +Q E + E KLQ E
Sbjct: 908 AKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKV 967
Query: 526 -LGGRIGALQLQLSQLHEQCSSLEKE--------------LKSEKEQRQALQR-ELQHE- 568
++ L+ + L +Q L KE L E+E+ ++L + + +HE
Sbjct: 968 TTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEA 1027
Query: 569 --KDTSSLLRMELQQVEGLKKELRELQDEKAELQKICEEQEQALQEMGLHLSQSKLKMED 626
D LR E +Q + L+K R+L+ + +L E + + E+ + L++ K E+
Sbjct: 1028 MITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAK---KEEE 1084
Query: 627 IKEVNQALKGHAWLKDDEATHCRQCEKEFS 656
++ ++ A K+ R+ E + S
Sbjct: 1085 LQAALARVEEEAAQKNMALKKIRELESQIS 1114
Score = 48.9 bits (115), Expect = 2e-05
Identities = 49/232 (21%), Positives = 101/232 (43%), Gaps = 30/232 (12%)
Query: 404 WKQLKEEKKVRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAIN 463
W +L + K L++ ++ E + + E+ +K+ EK +A +L E++ +
Sbjct: 827 WWRLFTKVKPLLQVSRQEEEMMAKEEEL---VKVREKQ--------LAAENRLTEMETLQ 875
Query: 464 LQMFHKAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQ 523
Q+ + + LQ + E E ++ + +++EE E + EER LQ
Sbjct: 876 SQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQ 935
Query: 524 QELGGRIGALQLQLSQLHEQCSSLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQVE 583
E ++ + LE++L+ E+ RQ LQ L+ + L ++E +Q+
Sbjct: 936 AE-----------KKKMQQNIQELEEQLEEEESARQKLQ--LEKVTTEAKLKKLEEEQII 982
Query: 584 ------GLKKELRELQDEKAELQKICEEQEQALQEMGLHLSQSKLKMEDIKE 629
L KE + L+D AE E+E+ + + ++ + + D++E
Sbjct: 983 LEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEE 1034
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 87.8 bits (216), Expect = 3e-17
Identities = 105/451 (23%), Positives = 194/451 (43%), Gaps = 73/451 (16%)
Query: 218 KKLADYLKVLIDNKHLLSEFYEPEALMMEEEGMVIVGLLVGLNVLDANLCLKGEDLDSQV 277
KKL D + V+ D + LS+ E ++EE + L NL +S +
Sbjct: 981 KKLEDEILVMDDQNNKLSK----ERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI 1036
Query: 278 GVIDFSLYLKDVQDLDGGKEHERITDVLDQ-KNYVEELNRHLSCTVGDLQTKIDGLEKTN 336
++ L K+ E+ L++ K +E + DLQ +I L+
Sbjct: 1037 SELEVRL-----------KKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQL 1085
Query: 337 SKLQEELSAATDRICSLQEEQQQLREQNELIRERSEKSVEITKQDTKVELETYKQTRQGL 396
+K +EEL AA R+ ++ ++N +++ E I+ D + +L++ + R
Sbjct: 1086 AKKEEELQAALARL------DDEIAQKNNALKKIRELEGHIS--DLQEDLDSERAARNKA 1137
Query: 397 DEMYSDVWKQLKEEKKVRLELEKEL-------ELQIGMKTEMEIAMKLLEKDT--HEKQ- 446
++ D+ ++L+ ++ ELE L EL+ + E+ + K L+++T HE Q
Sbjct: 1138 EKQKRDLGEELEA---LKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQV 1194
Query: 447 --------DTLVALRQQLEEVKAINLQMFHKAQNAESS-------LQQKNEAITSFEGKT 491
+ L +QLE+ K + Q E L+ +A E K
Sbjct: 1195 QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKK 1254
Query: 492 NQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGGRIGALQLQLSQLHEQCSSLEKEL 551
++ + +++++ + ERAR ++ HKLQ E+ G L++ + L K++
Sbjct: 1255 KKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG----MLNEAEGKAIKLAKDV 1310
Query: 552 KSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKELRELQDEKAELQKICEEQEQALQ 611
S Q Q DT LL+ E +Q + +LR+L++E+ LQ +E+ +A Q
Sbjct: 1311 ASLSSQLQ----------DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQ 1360
Query: 612 EMGLH-------LSQSKLKMEDIKEVNQALK 635
+ H LS SK K++D +AL+
Sbjct: 1361 NLERHISTLNIQLSDSKKKLQDFASTVEALE 1391
Score = 77.0 bits (188), Expect = 5e-14
Identities = 74/329 (22%), Positives = 155/329 (47%), Gaps = 35/329 (10%)
Query: 325 LQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQ--------------QLREQNELIRER 370
L TK+ L + ++ +EE+ A D + +E QQ QL E+ L++E+
Sbjct: 837 LFTKVKPLLQV-TRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 895
Query: 371 SEKSVEI--TKQDTKVELETYKQ-TRQGLDEMYS------DVWKQLKEEKK----VRLEL 417
+ E+ ++ +V L KQ + L EM + D +QL+ E+K L+L
Sbjct: 896 LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 955
Query: 418 EKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQNAESSL 477
E++LE + + ++++ E + +D ++ + Q ++ + + + ++L
Sbjct: 956 EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNL 1015
Query: 478 QQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGGRIGALQLQL 537
++ E + N+ S + ++E RL+ E++RQ E KL+++L G Q+
Sbjct: 1016 AEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE----KLKRKLEGDASDFHEQI 1071
Query: 538 SQLHEQCSSLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKELRELQDEKA 597
+ L Q + L+ +L ++E+ QA L E + +++++EG +L+E D +
Sbjct: 1072 ADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSER 1131
Query: 598 ELQKICEEQEQALQEMGLHLSQSKLKMED 626
+ E+Q+ +++G L K ++ED
Sbjct: 1132 AARNKAEKQK---RDLGEELEALKTELED 1157
Score = 73.9 bits (180), Expect = 5e-13
Identities = 77/318 (24%), Positives = 150/318 (47%), Gaps = 55/318 (17%)
Query: 324 DLQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQLREQNELIRERSEKSVEI--TKQD 381
++Q K D L+KT + Q+ A + + L+++ QL E+ L++E+ + E+ ++
Sbjct: 853 EMQAKEDELQKTKERQQK----AENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE 908
Query: 382 TKVELETYKQTRQGLDEMYSDVWKQLKEEKKVRLELEKELELQIGMKTEMEIAMKLLEKD 441
+V L KQ L+E+ ++ +L+EE+ +L+ E + ++A ++L+
Sbjct: 909 MRVRLAAKKQE---LEEILHEMEARLEEEEDRGQQLQAERK---------KMAQQMLD-- 954
Query: 442 THEKQDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQKNEAITSFEGKTNQVMSSMKQM 501
L +QLEE +A ++ + AE+ +++ + I + + N++ K +
Sbjct: 955 ----------LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLL 1004
Query: 502 EERLQHSERARQGAEERSHKLQQELGGRIGALQLQLSQLHE-QCSSLEKELKSEKEQRQA 560
EER+ EE++ L +L HE S LE LK E++ RQ
Sbjct: 1005 EERISDLTTNLAEEEEKAKNL------------TKLKNKHESMISELEVRLKKEEKSRQE 1052
Query: 561 LQR-ELQHEKDTSSLLRMELQQVEGLKKELRELQDEKAELQKICEEQEQALQEMGLHLSQ 619
L++ + + E D S +Q+ L+ ++ EL K +L K EE + AL + ++Q
Sbjct: 1053 LEKLKRKLEGDASDF----HEQIADLQAQIAEL---KMQLAKKEEELQAALARLDDEIAQ 1105
Query: 620 SKLKMEDIKEVNQALKGH 637
++ I+E L+GH
Sbjct: 1106 KNNALKKIRE----LEGH 1119
Score = 72.8 bits (177), Expect = 1e-12
Identities = 89/364 (24%), Positives = 161/364 (44%), Gaps = 60/364 (16%)
Query: 303 DVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQLRE 362
D++ K+ V + L + L+T+++ ++ +L++EL A D L+ Q L+
Sbjct: 1515 DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG 1574
Query: 363 QNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLKEEKKVRLELE-KEL 421
Q E + ++ E ++ + +L Y+ + DE + L K +LE + K+L
Sbjct: 1575 QFERDLQARDEQNEEKRRQLQRQLHEYETELE--DERKQ---RALAAAAKKKLEGDLKDL 1629
Query: 422 ELQIGMKTE-MEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQK 480
ELQ + E A+K L K + +D +++LE+ +A ++F A+ E
Sbjct: 1630 ELQADSAIKGREEAIKQLRKLQAQMKD----FQRELEDARASRDEIFATAKENEK----- 1680
Query: 481 NEAITSFEGKTNQVMSSMKQMEERLQHSERARQGA----EERSHKLQQELGGRIGALQLQ 536
K + + + Q++E L +ERAR+ A EE + +L L GR ALQ +
Sbjct: 1681 ---------KAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR-NALQDE 1730
Query: 537 LSQLHEQCSSLEKELKSEK--------------EQRQALQRELQHEKDTSSLLRMELQQV 582
+L + + LE+EL+ E+ +Q + L EL E+ T+ QQ+
Sbjct: 1731 KRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQL 1790
Query: 583 EGLKKELRELQDE----------------KAELQKICEEQEQALQEMGLHLSQSKLKMED 626
E KELR E +A++ ++ E+ EQ +E K K +
Sbjct: 1791 ERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKK 1850
Query: 627 IKEV 630
+KE+
Sbjct: 1851 LKEI 1854
Score = 69.7 bits (169), Expect = 9e-12
Identities = 79/398 (19%), Positives = 176/398 (44%), Gaps = 83/398 (20%)
Query: 300 RITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICSLQEE--- 356
R+ + D+ ++ + ++ + DL+ +++ E KLQ E A +I L++E
Sbjct: 930 RLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILV 989
Query: 357 ----QQQLREQNELIRER-SEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLKEEK 411
+L ++ +L+ ER S+ + + +++ K + T + + + M S++ +LK+E+
Sbjct: 990 MDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKH--ESMISELEVRLKKEE 1047
Query: 412 KVRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQ 471
K R ELEK + LE D + + + L+ Q+ E+K +Q+ K +
Sbjct: 1048 KSRQELEK--------------LKRKLEGDASDFHEQIADLQAQIAELK---MQLAKKEE 1090
Query: 472 NAESSLQQKNEAITSFEGKTNQVMSSMKQMEER---LQHSERARQGAEERSHKLQQELGG 528
+++L + ++ I + N + ++++E LQ + + A ++ K +++LG
Sbjct: 1091 ELQAALARLDDEIA----QKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1146
Query: 529 RIGALQLQLSQLHEQCSSLEKELKSEKEQ-----RQALQRELQ-HEKDTSSLLRMELQQV 582
+ AL+ +L + ++ ++EL++++EQ ++AL E + HE + + Q V
Sbjct: 1147 ELEALKTELEDTLDSTAT-QQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAV 1205
Query: 583 EGLKKELRELQDEKA------------------------------------------ELQ 600
E L ++L + + KA ELQ
Sbjct: 1206 EELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1265
Query: 601 KICEEQEQALQEMGLHLSQSKLKMEDIKEVNQALKGHA 638
C + E+A E+ + + + ++E + + +G A
Sbjct: 1266 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1303
Score = 66.2 bits (160), Expect = 1e-10
Identities = 72/364 (19%), Positives = 172/364 (47%), Gaps = 31/364 (8%)
Query: 288 DVQDLDGGKEHERITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAAT 347
++Q L G + ER D++N EE R L + + +T+++ K Q L+AA
Sbjct: 1568 NMQALKG--QFERDLQARDEQN--EEKRRQLQRQLHEYETELEDERK-----QRALAAAA 1618
Query: 348 DRICSLQEEQQQLREQ-NELIRERSEKSVEITK-----QDTKVELETYKQTRQGLDEMYS 401
+ L+ + + L Q + I+ R E ++ K +D + ELE + +R DE+++
Sbjct: 1619 KK--KLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASR---DEIFA 1673
Query: 402 DVWKQLKEEKKVR---LELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEE 458
+ K+ K + ++L+++L + + ++ + L ++ AL+ +
Sbjct: 1674 TAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRR 1733
Query: 459 VKAINLQMFHKAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEER 518
++A Q+ + + + +++ ++ + + Q+ + + Q +E ARQ E +
Sbjct: 1734 LEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQ 1793
Query: 519 SHKLQQELGGRIGALQLQ----LSQLHEQCSSLEKELKSEKEQRQALQREL-QHEKDTSS 573
+ +L+ +L GA++ + ++ L + + LE++++ E ++QA + L Q +K
Sbjct: 1794 NKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKE 1853
Query: 574 LLRM---ELQQVEGLKKELRELQDEKAELQKICEEQEQALQEMGLHLSQSKLKMEDIKEV 630
+L E + E K++ + +L++ EE E+ Q + + + + ++++ E
Sbjct: 1854 ILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATES 1913
Query: 631 NQAL 634
N+A+
Sbjct: 1914 NEAM 1917
Score = 63.5 bits (153), Expect = 6e-10
Identities = 73/378 (19%), Positives = 168/378 (44%), Gaps = 25/378 (6%)
Query: 263 DANLCLKGEDLDSQVGVIDFSLYLKDVQDLDGGKE-----HERITDVLD---QKNYVEEL 314
DA L L+ ++ + G + L +D Q+ + ++ HE T++ D Q+
Sbjct: 1560 DAKLRLE-VNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAA 1618
Query: 315 NRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQLREQNELI------R 368
+ L + DL+ + D K + ++L ++ Q E + R + I
Sbjct: 1619 KKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKEN 1678
Query: 369 ERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLKEEKKVRLELEKELELQIGMK 428
E+ KS+E + +L ++ R+ D ++ ++L R L+ E K
Sbjct: 1679 EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDE-------K 1731
Query: 429 TEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQKNEAITSFE 488
+E + LE++ E+Q + A+ ++ + Q+ ++ S+ Q+ A E
Sbjct: 1732 RRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE 1791
Query: 489 GKTNQVMSSMKQMEERLQHSERARQGA-EERSHKLQQELGGRIGALQLQLSQLHEQCSSL 547
+ ++ S + +ME ++ ++ A E + +L++++ Q L ++ L
Sbjct: 1792 RQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKL 1851
Query: 548 EKEL-KSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKELRELQDEKAELQKICEEQ 606
++ L + E E++ A Q + Q EK + + +++ +Q+E ++E + + + +LQ+ +E
Sbjct: 1852 KEILLQVEDERKMAEQYKEQAEKGNARVKQLK-RQLEEAEEESQRINANRRKLQRELDEA 1910
Query: 607 EQALQEMGLHLSQSKLKM 624
++ + MG ++ K K+
Sbjct: 1911 TESNEAMGREVNALKSKL 1928
Score = 60.8 bits (146), Expect = 4e-09
Identities = 82/398 (20%), Positives = 171/398 (42%), Gaps = 74/398 (18%)
Query: 308 KNYVEELNRHLSCTVGDLQTKIDGLEKTNS-------KLQEELSAATDRICSLQEEQQQL 360
K VE + L V +LQ+K E+ + KLQ E+ + T + + + +L
Sbjct: 1247 KQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKL 1306
Query: 361 REQNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLKEEKKVRLELEKE 420
+ + + + + E+ +++T+ +L + RQ L+E + + QL EE + + LE+
Sbjct: 1307 AKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ-LEEERNSLQDQLDEEMEAKQNLERH 1365
Query: 421 L-----ELQIGMKTEMEIA--MKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQNA 473
+ +L K + A ++ LE+ Q + L QQ EE A + K +
Sbjct: 1366 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAA----YDKLEKT 1421
Query: 474 ESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQH-------------SERARQGAE---- 516
++ LQQ+ + + Q++S++++ + + ER R AE
Sbjct: 1422 KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1481
Query: 517 ---------------------ERSHKL----QQELGGRIGALQLQLSQLHEQCSSLEKEL 551
ER++K+ ++L + + +L + +LE ++
Sbjct: 1482 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM 1541
Query: 552 KSEKEQRQALQRELQHEKDTSSLLRMELQQVEG-----LKKELRELQDEKAELQKICEEQ 606
+ K Q + L+ ELQ +D L + +Q ++G L+ + ++++ +LQ+ E
Sbjct: 1542 EEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEY 1601
Query: 607 EQALQE---MGLHLSQSKLKME-DIKEV----NQALKG 636
E L++ + +K K+E D+K++ + A+KG
Sbjct: 1602 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKG 1639
Score = 54.3 bits (129), Expect = 4e-07
Identities = 43/218 (19%), Positives = 101/218 (46%), Gaps = 9/218 (4%)
Query: 429 TEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQKNEAITSFE 488
T E M+ E + + ++ +L+E++ + Q+ + + LQ + E E
Sbjct: 848 TRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAE 907
Query: 489 GKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGGRIGALQLQLSQLHEQCSSLE 548
++ + +++EE L E + E+R +LQ E ++ L L + E+ +
Sbjct: 908 EMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAE-RKKMAQQMLDLEEQLEEEEAAR 966
Query: 549 KELKSEKEQRQALQRELQHE----KDTSSLLRMEL----QQVEGLKKELRELQDEKAELQ 600
++L+ EK +A ++L+ E D ++ L E +++ L L E +++ L
Sbjct: 967 QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1026
Query: 601 KICEEQEQALQEMGLHLSQSKLKMEDIKEVNQALKGHA 638
K+ + E + E+ + L + + ++++++ + L+G A
Sbjct: 1027 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDA 1064
Score = 38.5 bits (88), Expect = 0.022
Identities = 58/318 (18%), Positives = 127/318 (39%), Gaps = 55/318 (17%)
Query: 205 GRGRAWLYLALMQKKLADYLKVLIDNKHLLSEFYEPEALMMEEEGMVIVGLLVGLNVLDA 264
GR A L +Q ++ D+ + L D + E + A E E L+A
Sbjct: 1639 GREEAIKQLRKLQAQMKDFQRELEDARASRDEIF---ATAKENEKKA--------KSLEA 1687
Query: 265 NLCLKGEDLDSQVGVIDFSLYLKDVQDLDGGKEHERITDVLDQKNYVEELNRHLSCTVGD 324
+L EDL + + DL+ + E + L +N +++ R L +
Sbjct: 1688 DLMQLQEDLAAAERA-------RKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQ 1740
Query: 325 LQTKIDGLEKTNSKLQEELSAATDRICSLQEE--------------QQQLREQNELIRER 370
L+ +++ + + + + AT + L E +QQL QN+ +R +
Sbjct: 1741 LEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSK 1800
Query: 371 SEK----------------SVEITKQDTKVELETYKQ-----TRQGLDEMYSDVWKQLKE 409
+ +I + + +VE E ++ + + D+ ++ Q+++
Sbjct: 1801 LHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVED 1860
Query: 410 EKKVRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHK 469
E+K+ + +++ E +++ ++ E+++ L+++L+E N M +
Sbjct: 1861 ERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGRE 1920
Query: 470 AQNAESSLQQKNEAITSF 487
+S L++ NE TSF
Sbjct: 1921 VNALKSKLRRGNE--TSF 1936
Score = 32.3 bits (72), Expect = 1.6
Identities = 20/78 (25%), Positives = 40/78 (51%)
Query: 550 ELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKELRELQDEKAELQKICEEQEQA 609
++ ++E+ QA + ELQ K+ EL+++E +L E ++ E + E
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 905
Query: 610 LQEMGLHLSQSKLKMEDI 627
+EM + L+ K ++E+I
Sbjct: 906 AEEMRVRLAAKKQELEEI 923
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 87.8 bits (216), Expect = 3e-17
Identities = 105/451 (23%), Positives = 194/451 (43%), Gaps = 73/451 (16%)
Query: 218 KKLADYLKVLIDNKHLLSEFYEPEALMMEEEGMVIVGLLVGLNVLDANLCLKGEDLDSQV 277
KKL D + V+ D + LS+ E ++EE + L NL +S +
Sbjct: 988 KKLEDEILVMDDQNNKLSK----ERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI 1043
Query: 278 GVIDFSLYLKDVQDLDGGKEHERITDVLDQ-KNYVEELNRHLSCTVGDLQTKIDGLEKTN 336
++ L K+ E+ L++ K +E + DLQ +I L+
Sbjct: 1044 SELEVRL-----------KKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQL 1092
Query: 337 SKLQEELSAATDRICSLQEEQQQLREQNELIRERSEKSVEITKQDTKVELETYKQTRQGL 396
+K +EEL AA R+ ++ ++N +++ E I+ D + +L++ + R
Sbjct: 1093 AKKEEELQAALARL------DDEIAQKNNALKKIRELEGHIS--DLQEDLDSERAARNKA 1144
Query: 397 DEMYSDVWKQLKEEKKVRLELEKEL-------ELQIGMKTEMEIAMKLLEKDT--HEKQ- 446
++ D+ ++L+ ++ ELE L EL+ + E+ + K L+++T HE Q
Sbjct: 1145 EKQKRDLGEELEA---LKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQV 1201
Query: 447 --------DTLVALRQQLEEVKAINLQMFHKAQNAESS-------LQQKNEAITSFEGKT 491
+ L +QLE+ K + Q E L+ +A E K
Sbjct: 1202 QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKK 1261
Query: 492 NQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGGRIGALQLQLSQLHEQCSSLEKEL 551
++ + +++++ + ERAR ++ HKLQ E+ G L++ + L K++
Sbjct: 1262 KKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG----MLNEAEGKAIKLAKDV 1317
Query: 552 KSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKELRELQDEKAELQKICEEQEQALQ 611
S Q Q DT LL+ E +Q + +LR+L++E+ LQ +E+ +A Q
Sbjct: 1318 ASLSSQLQ----------DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQ 1367
Query: 612 EMGLH-------LSQSKLKMEDIKEVNQALK 635
+ H LS SK K++D +AL+
Sbjct: 1368 NLERHISTLNIQLSDSKKKLQDFASTVEALE 1398
Score = 77.0 bits (188), Expect = 5e-14
Identities = 74/329 (22%), Positives = 155/329 (47%), Gaps = 35/329 (10%)
Query: 325 LQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQ--------------QLREQNELIRER 370
L TK+ L + ++ +EE+ A D + +E QQ QL E+ L++E+
Sbjct: 844 LFTKVKPLLQV-TRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 902
Query: 371 SEKSVEI--TKQDTKVELETYKQ-TRQGLDEMYS------DVWKQLKEEKK----VRLEL 417
+ E+ ++ +V L KQ + L EM + D +QL+ E+K L+L
Sbjct: 903 LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 962
Query: 418 EKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQNAESSL 477
E++LE + + ++++ E + +D ++ + Q ++ + + + ++L
Sbjct: 963 EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNL 1022
Query: 478 QQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGGRIGALQLQL 537
++ E + N+ S + ++E RL+ E++RQ E KL+++L G Q+
Sbjct: 1023 AEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE----KLKRKLEGDASDFHEQI 1078
Query: 538 SQLHEQCSSLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKELRELQDEKA 597
+ L Q + L+ +L ++E+ QA L E + +++++EG +L+E D +
Sbjct: 1079 ADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSER 1138
Query: 598 ELQKICEEQEQALQEMGLHLSQSKLKMED 626
+ E+Q+ +++G L K ++ED
Sbjct: 1139 AARNKAEKQK---RDLGEELEALKTELED 1164
Score = 73.9 bits (180), Expect = 5e-13
Identities = 77/318 (24%), Positives = 150/318 (47%), Gaps = 55/318 (17%)
Query: 324 DLQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQLREQNELIRERSEKSVEI--TKQD 381
++Q K D L+KT + Q+ A + + L+++ QL E+ L++E+ + E+ ++
Sbjct: 860 EMQAKEDELQKTKERQQK----AENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE 915
Query: 382 TKVELETYKQTRQGLDEMYSDVWKQLKEEKKVRLELEKELELQIGMKTEMEIAMKLLEKD 441
+V L KQ L+E+ ++ +L+EE+ +L+ E + ++A ++L+
Sbjct: 916 MRVRLAAKKQE---LEEILHEMEARLEEEEDRGQQLQAERK---------KMAQQMLD-- 961
Query: 442 THEKQDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQKNEAITSFEGKTNQVMSSMKQM 501
L +QLEE +A ++ + AE+ +++ + I + + N++ K +
Sbjct: 962 ----------LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLL 1011
Query: 502 EERLQHSERARQGAEERSHKLQQELGGRIGALQLQLSQLHE-QCSSLEKELKSEKEQRQA 560
EER+ EE++ L +L HE S LE LK E++ RQ
Sbjct: 1012 EERISDLTTNLAEEEEKAKNL------------TKLKNKHESMISELEVRLKKEEKSRQE 1059
Query: 561 LQR-ELQHEKDTSSLLRMELQQVEGLKKELRELQDEKAELQKICEEQEQALQEMGLHLSQ 619
L++ + + E D S +Q+ L+ ++ EL K +L K EE + AL + ++Q
Sbjct: 1060 LEKLKRKLEGDASDF----HEQIADLQAQIAEL---KMQLAKKEEELQAALARLDDEIAQ 1112
Query: 620 SKLKMEDIKEVNQALKGH 637
++ I+E L+GH
Sbjct: 1113 KNNALKKIRE----LEGH 1126
Score = 72.8 bits (177), Expect = 1e-12
Identities = 89/364 (24%), Positives = 161/364 (44%), Gaps = 60/364 (16%)
Query: 303 DVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQLRE 362
D++ K+ V + L + L+T+++ ++ +L++EL A D L+ Q L+
Sbjct: 1522 DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG 1581
Query: 363 QNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLKEEKKVRLELE-KEL 421
Q E + ++ E ++ + +L Y+ + DE + L K +LE + K+L
Sbjct: 1582 QFERDLQARDEQNEEKRRQLQRQLHEYETELE--DERKQ---RALAAAAKKKLEGDLKDL 1636
Query: 422 ELQIGMKTE-MEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQK 480
ELQ + E A+K L K + +D +++LE+ +A ++F A+ E
Sbjct: 1637 ELQADSAIKGREEAIKQLRKLQAQMKD----FQRELEDARASRDEIFATAKENEK----- 1687
Query: 481 NEAITSFEGKTNQVMSSMKQMEERLQHSERARQGA----EERSHKLQQELGGRIGALQLQ 536
K + + + Q++E L +ERAR+ A EE + +L L GR ALQ +
Sbjct: 1688 ---------KAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR-NALQDE 1737
Query: 537 LSQLHEQCSSLEKELKSEK--------------EQRQALQRELQHEKDTSSLLRMELQQV 582
+L + + LE+EL+ E+ +Q + L EL E+ T+ QQ+
Sbjct: 1738 KRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQL 1797
Query: 583 EGLKKELRELQDE----------------KAELQKICEEQEQALQEMGLHLSQSKLKMED 626
E KELR E +A++ ++ E+ EQ +E K K +
Sbjct: 1798 ERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKK 1857
Query: 627 IKEV 630
+KE+
Sbjct: 1858 LKEI 1861
Score = 69.7 bits (169), Expect = 9e-12
Identities = 79/398 (19%), Positives = 176/398 (44%), Gaps = 83/398 (20%)
Query: 300 RITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICSLQEE--- 356
R+ + D+ ++ + ++ + DL+ +++ E KLQ E A +I L++E
Sbjct: 937 RLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILV 996
Query: 357 ----QQQLREQNELIRER-SEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLKEEK 411
+L ++ +L+ ER S+ + + +++ K + T + + + M S++ +LK+E+
Sbjct: 997 MDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKH--ESMISELEVRLKKEE 1054
Query: 412 KVRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQ 471
K R ELEK + LE D + + + L+ Q+ E+K +Q+ K +
Sbjct: 1055 KSRQELEK--------------LKRKLEGDASDFHEQIADLQAQIAELK---MQLAKKEE 1097
Query: 472 NAESSLQQKNEAITSFEGKTNQVMSSMKQMEER---LQHSERARQGAEERSHKLQQELGG 528
+++L + ++ I + N + ++++E LQ + + A ++ K +++LG
Sbjct: 1098 ELQAALARLDDEIA----QKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1153
Query: 529 RIGALQLQLSQLHEQCSSLEKELKSEKEQ-----RQALQRELQ-HEKDTSSLLRMELQQV 582
+ AL+ +L + ++ ++EL++++EQ ++AL E + HE + + Q V
Sbjct: 1154 ELEALKTELEDTLDSTAT-QQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAV 1212
Query: 583 EGLKKELRELQDEKA------------------------------------------ELQ 600
E L ++L + + KA ELQ
Sbjct: 1213 EELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1272
Query: 601 KICEEQEQALQEMGLHLSQSKLKMEDIKEVNQALKGHA 638
C + E+A E+ + + + ++E + + +G A
Sbjct: 1273 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1310
Score = 66.2 bits (160), Expect = 1e-10
Identities = 72/364 (19%), Positives = 172/364 (47%), Gaps = 31/364 (8%)
Query: 288 DVQDLDGGKEHERITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAAT 347
++Q L G + ER D++N EE R L + + +T+++ K Q L+AA
Sbjct: 1575 NMQALKG--QFERDLQARDEQN--EEKRRQLQRQLHEYETELEDERK-----QRALAAAA 1625
Query: 348 DRICSLQEEQQQLREQ-NELIRERSEKSVEITK-----QDTKVELETYKQTRQGLDEMYS 401
+ L+ + + L Q + I+ R E ++ K +D + ELE + +R DE+++
Sbjct: 1626 KK--KLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASR---DEIFA 1680
Query: 402 DVWKQLKEEKKVR---LELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEE 458
+ K+ K + ++L+++L + + ++ + L ++ AL+ +
Sbjct: 1681 TAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRR 1740
Query: 459 VKAINLQMFHKAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEER 518
++A Q+ + + + +++ ++ + + Q+ + + Q +E ARQ E +
Sbjct: 1741 LEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQ 1800
Query: 519 SHKLQQELGGRIGALQLQ----LSQLHEQCSSLEKELKSEKEQRQALQREL-QHEKDTSS 573
+ +L+ +L GA++ + ++ L + + LE++++ E ++QA + L Q +K
Sbjct: 1801 NKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKE 1860
Query: 574 LLRM---ELQQVEGLKKELRELQDEKAELQKICEEQEQALQEMGLHLSQSKLKMEDIKEV 630
+L E + E K++ + +L++ EE E+ Q + + + + ++++ E
Sbjct: 1861 ILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATES 1920
Query: 631 NQAL 634
N+A+
Sbjct: 1921 NEAM 1924
Score = 63.5 bits (153), Expect = 6e-10
Identities = 73/378 (19%), Positives = 168/378 (44%), Gaps = 25/378 (6%)
Query: 263 DANLCLKGEDLDSQVGVIDFSLYLKDVQDLDGGKE-----HERITDVLD---QKNYVEEL 314
DA L L+ ++ + G + L +D Q+ + ++ HE T++ D Q+
Sbjct: 1567 DAKLRLE-VNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAA 1625
Query: 315 NRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQLREQNELI------R 368
+ L + DL+ + D K + ++L ++ Q E + R + I
Sbjct: 1626 KKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKEN 1685
Query: 369 ERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLKEEKKVRLELEKELELQIGMK 428
E+ KS+E + +L ++ R+ D ++ ++L R L+ E K
Sbjct: 1686 EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDE-------K 1738
Query: 429 TEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQKNEAITSFE 488
+E + LE++ E+Q + A+ ++ + Q+ ++ S+ Q+ A E
Sbjct: 1739 RRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE 1798
Query: 489 GKTNQVMSSMKQMEERLQHSERARQGA-EERSHKLQQELGGRIGALQLQLSQLHEQCSSL 547
+ ++ S + +ME ++ ++ A E + +L++++ Q L ++ L
Sbjct: 1799 RQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKL 1858
Query: 548 EKEL-KSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKELRELQDEKAELQKICEEQ 606
++ L + E E++ A Q + Q EK + + +++ +Q+E ++E + + + +LQ+ +E
Sbjct: 1859 KEILLQVEDERKMAEQYKEQAEKGNARVKQLK-RQLEEAEEESQRINANRRKLQRELDEA 1917
Query: 607 EQALQEMGLHLSQSKLKM 624
++ + MG ++ K K+
Sbjct: 1918 TESNEAMGREVNALKSKL 1935
Score = 60.8 bits (146), Expect = 4e-09
Identities = 82/398 (20%), Positives = 171/398 (42%), Gaps = 74/398 (18%)
Query: 308 KNYVEELNRHLSCTVGDLQTKIDGLEKTNS-------KLQEELSAATDRICSLQEEQQQL 360
K VE + L V +LQ+K E+ + KLQ E+ + T + + + +L
Sbjct: 1254 KQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKL 1313
Query: 361 REQNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLKEEKKVRLELEKE 420
+ + + + + E+ +++T+ +L + RQ L+E + + QL EE + + LE+
Sbjct: 1314 AKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ-LEEERNSLQDQLDEEMEAKQNLERH 1372
Query: 421 L-----ELQIGMKTEMEIA--MKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQNA 473
+ +L K + A ++ LE+ Q + L QQ EE A + K +
Sbjct: 1373 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAA----YDKLEKT 1428
Query: 474 ESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQH-------------SERARQGAE---- 516
++ LQQ+ + + Q++S++++ + + ER R AE
Sbjct: 1429 KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1488
Query: 517 ---------------------ERSHKL----QQELGGRIGALQLQLSQLHEQCSSLEKEL 551
ER++K+ ++L + + +L + +LE ++
Sbjct: 1489 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM 1548
Query: 552 KSEKEQRQALQRELQHEKDTSSLLRMELQQVEG-----LKKELRELQDEKAELQKICEEQ 606
+ K Q + L+ ELQ +D L + +Q ++G L+ + ++++ +LQ+ E
Sbjct: 1549 EEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEY 1608
Query: 607 EQALQE---MGLHLSQSKLKME-DIKEV----NQALKG 636
E L++ + +K K+E D+K++ + A+KG
Sbjct: 1609 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKG 1646
Score = 54.3 bits (129), Expect = 4e-07
Identities = 43/218 (19%), Positives = 101/218 (46%), Gaps = 9/218 (4%)
Query: 429 TEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQKNEAITSFE 488
T E M+ E + + ++ +L+E++ + Q+ + + LQ + E E
Sbjct: 855 TRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAE 914
Query: 489 GKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGGRIGALQLQLSQLHEQCSSLE 548
++ + +++EE L E + E+R +LQ E ++ L L + E+ +
Sbjct: 915 EMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAE-RKKMAQQMLDLEEQLEEEEAAR 973
Query: 549 KELKSEKEQRQALQRELQHE----KDTSSLLRMEL----QQVEGLKKELRELQDEKAELQ 600
++L+ EK +A ++L+ E D ++ L E +++ L L E +++ L
Sbjct: 974 QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1033
Query: 601 KICEEQEQALQEMGLHLSQSKLKMEDIKEVNQALKGHA 638
K+ + E + E+ + L + + ++++++ + L+G A
Sbjct: 1034 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDA 1071
Score = 38.5 bits (88), Expect = 0.022
Identities = 58/318 (18%), Positives = 127/318 (39%), Gaps = 55/318 (17%)
Query: 205 GRGRAWLYLALMQKKLADYLKVLIDNKHLLSEFYEPEALMMEEEGMVIVGLLVGLNVLDA 264
GR A L +Q ++ D+ + L D + E + A E E L+A
Sbjct: 1646 GREEAIKQLRKLQAQMKDFQRELEDARASRDEIF---ATAKENEKKA--------KSLEA 1694
Query: 265 NLCLKGEDLDSQVGVIDFSLYLKDVQDLDGGKEHERITDVLDQKNYVEELNRHLSCTVGD 324
+L EDL + + DL+ + E + L +N +++ R L +
Sbjct: 1695 DLMQLQEDLAAAERA-------RKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQ 1747
Query: 325 LQTKIDGLEKTNSKLQEELSAATDRICSLQEE--------------QQQLREQNELIRER 370
L+ +++ + + + + AT + L E +QQL QN+ +R +
Sbjct: 1748 LEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSK 1807
Query: 371 SEK----------------SVEITKQDTKVELETYKQ-----TRQGLDEMYSDVWKQLKE 409
+ +I + + +VE E ++ + + D+ ++ Q+++
Sbjct: 1808 LHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVED 1867
Query: 410 EKKVRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHK 469
E+K+ + +++ E +++ ++ E+++ L+++L+E N M +
Sbjct: 1868 ERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGRE 1927
Query: 470 AQNAESSLQQKNEAITSF 487
+S L++ NE TSF
Sbjct: 1928 VNALKSKLRRGNE--TSF 1943
Score = 32.3 bits (72), Expect = 1.6
Identities = 20/78 (25%), Positives = 40/78 (51%)
Query: 550 ELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKELRELQDEKAELQKICEEQEQA 609
++ ++E+ QA + ELQ K+ EL+++E +L E ++ E + E
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912
Query: 610 LQEMGLHLSQSKLKMEDI 627
+EM + L+ K ++E+I
Sbjct: 913 AEEMRVRLAAKKQELEEI 930
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 87.8 bits (216), Expect = 3e-17
Identities = 105/451 (23%), Positives = 194/451 (43%), Gaps = 73/451 (16%)
Query: 218 KKLADYLKVLIDNKHLLSEFYEPEALMMEEEGMVIVGLLVGLNVLDANLCLKGEDLDSQV 277
KKL D + V+ D + LS+ E ++EE + L NL +S +
Sbjct: 988 KKLEDEILVMDDQNNKLSK----ERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI 1043
Query: 278 GVIDFSLYLKDVQDLDGGKEHERITDVLDQ-KNYVEELNRHLSCTVGDLQTKIDGLEKTN 336
++ L K+ E+ L++ K +E + DLQ +I L+
Sbjct: 1044 SELEVRL-----------KKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQL 1092
Query: 337 SKLQEELSAATDRICSLQEEQQQLREQNELIRERSEKSVEITKQDTKVELETYKQTRQGL 396
+K +EEL AA R+ ++ ++N +++ E I+ D + +L++ + R
Sbjct: 1093 AKKEEELQAALARL------DDEIAQKNNALKKIRELEGHIS--DLQEDLDSERAARNKA 1144
Query: 397 DEMYSDVWKQLKEEKKVRLELEKEL-------ELQIGMKTEMEIAMKLLEKDT--HEKQ- 446
++ D+ ++L+ ++ ELE L EL+ + E+ + K L+++T HE Q
Sbjct: 1145 EKQKRDLGEELEA---LKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQV 1201
Query: 447 --------DTLVALRQQLEEVKAINLQMFHKAQNAESS-------LQQKNEAITSFEGKT 491
+ L +QLE+ K + Q E L+ +A E K
Sbjct: 1202 QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKK 1261
Query: 492 NQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGGRIGALQLQLSQLHEQCSSLEKEL 551
++ + +++++ + ERAR ++ HKLQ E+ G L++ + L K++
Sbjct: 1262 KKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG----MLNEAEGKAIKLAKDV 1317
Query: 552 KSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKELRELQDEKAELQKICEEQEQALQ 611
S Q Q DT LL+ E +Q + +LR+L++E+ LQ +E+ +A Q
Sbjct: 1318 ASLSSQLQ----------DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQ 1367
Query: 612 EMGLH-------LSQSKLKMEDIKEVNQALK 635
+ H LS SK K++D +AL+
Sbjct: 1368 NLERHISTLNIQLSDSKKKLQDFASTVEALE 1398
Score = 77.0 bits (188), Expect = 5e-14
Identities = 74/329 (22%), Positives = 155/329 (47%), Gaps = 35/329 (10%)
Query: 325 LQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQ--------------QLREQNELIRER 370
L TK+ L + ++ +EE+ A D + +E QQ QL E+ L++E+
Sbjct: 844 LFTKVKPLLQV-TRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 902
Query: 371 SEKSVEI--TKQDTKVELETYKQ-TRQGLDEMYS------DVWKQLKEEKK----VRLEL 417
+ E+ ++ +V L KQ + L EM + D +QL+ E+K L+L
Sbjct: 903 LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 962
Query: 418 EKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQNAESSL 477
E++LE + + ++++ E + +D ++ + Q ++ + + + ++L
Sbjct: 963 EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNL 1022
Query: 478 QQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGGRIGALQLQL 537
++ E + N+ S + ++E RL+ E++RQ E KL+++L G Q+
Sbjct: 1023 AEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE----KLKRKLEGDASDFHEQI 1078
Query: 538 SQLHEQCSSLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKELRELQDEKA 597
+ L Q + L+ +L ++E+ QA L E + +++++EG +L+E D +
Sbjct: 1079 ADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSER 1138
Query: 598 ELQKICEEQEQALQEMGLHLSQSKLKMED 626
+ E+Q+ +++G L K ++ED
Sbjct: 1139 AARNKAEKQK---RDLGEELEALKTELED 1164
Score = 73.9 bits (180), Expect = 5e-13
Identities = 77/318 (24%), Positives = 150/318 (47%), Gaps = 55/318 (17%)
Query: 324 DLQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQLREQNELIRERSEKSVEI--TKQD 381
++Q K D L+KT + Q+ A + + L+++ QL E+ L++E+ + E+ ++
Sbjct: 860 EMQAKEDELQKTKERQQK----AENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE 915
Query: 382 TKVELETYKQTRQGLDEMYSDVWKQLKEEKKVRLELEKELELQIGMKTEMEIAMKLLEKD 441
+V L KQ L+E+ ++ +L+EE+ +L+ E + ++A ++L+
Sbjct: 916 MRVRLAAKKQE---LEEILHEMEARLEEEEDRGQQLQAERK---------KMAQQMLD-- 961
Query: 442 THEKQDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQKNEAITSFEGKTNQVMSSMKQM 501
L +QLEE +A ++ + AE+ +++ + I + + N++ K +
Sbjct: 962 ----------LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLL 1011
Query: 502 EERLQHSERARQGAEERSHKLQQELGGRIGALQLQLSQLHE-QCSSLEKELKSEKEQRQA 560
EER+ EE++ L +L HE S LE LK E++ RQ
Sbjct: 1012 EERISDLTTNLAEEEEKAKNL------------TKLKNKHESMISELEVRLKKEEKSRQE 1059
Query: 561 LQR-ELQHEKDTSSLLRMELQQVEGLKKELRELQDEKAELQKICEEQEQALQEMGLHLSQ 619
L++ + + E D S +Q+ L+ ++ EL K +L K EE + AL + ++Q
Sbjct: 1060 LEKLKRKLEGDASDF----HEQIADLQAQIAEL---KMQLAKKEEELQAALARLDDEIAQ 1112
Query: 620 SKLKMEDIKEVNQALKGH 637
++ I+E L+GH
Sbjct: 1113 KNNALKKIRE----LEGH 1126
Score = 72.8 bits (177), Expect = 1e-12
Identities = 89/364 (24%), Positives = 161/364 (44%), Gaps = 60/364 (16%)
Query: 303 DVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQLRE 362
D++ K+ V + L + L+T+++ ++ +L++EL A D L+ Q L+
Sbjct: 1522 DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG 1581
Query: 363 QNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLKEEKKVRLELE-KEL 421
Q E + ++ E ++ + +L Y+ + DE + L K +LE + K+L
Sbjct: 1582 QFERDLQARDEQNEEKRRQLQRQLHEYETELE--DERKQ---RALAAAAKKKLEGDLKDL 1636
Query: 422 ELQIGMKTE-MEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQK 480
ELQ + E A+K L K + +D +++LE+ +A ++F A+ E
Sbjct: 1637 ELQADSAIKGREEAIKQLRKLQAQMKD----FQRELEDARASRDEIFATAKENEK----- 1687
Query: 481 NEAITSFEGKTNQVMSSMKQMEERLQHSERARQGA----EERSHKLQQELGGRIGALQLQ 536
K + + + Q++E L +ERAR+ A EE + +L L GR ALQ +
Sbjct: 1688 ---------KAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR-NALQDE 1737
Query: 537 LSQLHEQCSSLEKELKSEK--------------EQRQALQRELQHEKDTSSLLRMELQQV 582
+L + + LE+EL+ E+ +Q + L EL E+ T+ QQ+
Sbjct: 1738 KRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQL 1797
Query: 583 EGLKKELRELQDE----------------KAELQKICEEQEQALQEMGLHLSQSKLKMED 626
E KELR E +A++ ++ E+ EQ +E K K +
Sbjct: 1798 ERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKK 1857
Query: 627 IKEV 630
+KE+
Sbjct: 1858 LKEI 1861
Score = 69.7 bits (169), Expect = 9e-12
Identities = 79/398 (19%), Positives = 176/398 (44%), Gaps = 83/398 (20%)
Query: 300 RITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICSLQEE--- 356
R+ + D+ ++ + ++ + DL+ +++ E KLQ E A +I L++E
Sbjct: 937 RLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILV 996
Query: 357 ----QQQLREQNELIRER-SEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLKEEK 411
+L ++ +L+ ER S+ + + +++ K + T + + + M S++ +LK+E+
Sbjct: 997 MDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKH--ESMISELEVRLKKEE 1054
Query: 412 KVRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQ 471
K R ELEK + LE D + + + L+ Q+ E+K +Q+ K +
Sbjct: 1055 KSRQELEK--------------LKRKLEGDASDFHEQIADLQAQIAELK---MQLAKKEE 1097
Query: 472 NAESSLQQKNEAITSFEGKTNQVMSSMKQMEER---LQHSERARQGAEERSHKLQQELGG 528
+++L + ++ I + N + ++++E LQ + + A ++ K +++LG
Sbjct: 1098 ELQAALARLDDEIA----QKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1153
Query: 529 RIGALQLQLSQLHEQCSSLEKELKSEKEQ-----RQALQRELQ-HEKDTSSLLRMELQQV 582
+ AL+ +L + ++ ++EL++++EQ ++AL E + HE + + Q V
Sbjct: 1154 ELEALKTELEDTLDSTAT-QQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAV 1212
Query: 583 EGLKKELRELQDEKA------------------------------------------ELQ 600
E L ++L + + KA ELQ
Sbjct: 1213 EELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1272
Query: 601 KICEEQEQALQEMGLHLSQSKLKMEDIKEVNQALKGHA 638
C + E+A E+ + + + ++E + + +G A
Sbjct: 1273 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1310
Score = 66.2 bits (160), Expect = 1e-10
Identities = 72/364 (19%), Positives = 172/364 (47%), Gaps = 31/364 (8%)
Query: 288 DVQDLDGGKEHERITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAAT 347
++Q L G + ER D++N EE R L + + +T+++ K Q L+AA
Sbjct: 1575 NMQALKG--QFERDLQARDEQN--EEKRRQLQRQLHEYETELEDERK-----QRALAAAA 1625
Query: 348 DRICSLQEEQQQLREQ-NELIRERSEKSVEITK-----QDTKVELETYKQTRQGLDEMYS 401
+ L+ + + L Q + I+ R E ++ K +D + ELE + +R DE+++
Sbjct: 1626 KK--KLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASR---DEIFA 1680
Query: 402 DVWKQLKEEKKVR---LELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEE 458
+ K+ K + ++L+++L + + ++ + L ++ AL+ +
Sbjct: 1681 TAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRR 1740
Query: 459 VKAINLQMFHKAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEER 518
++A Q+ + + + +++ ++ + + Q+ + + Q +E ARQ E +
Sbjct: 1741 LEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQ 1800
Query: 519 SHKLQQELGGRIGALQLQ----LSQLHEQCSSLEKELKSEKEQRQALQREL-QHEKDTSS 573
+ +L+ +L GA++ + ++ L + + LE++++ E ++QA + L Q +K
Sbjct: 1801 NKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKE 1860
Query: 574 LLRM---ELQQVEGLKKELRELQDEKAELQKICEEQEQALQEMGLHLSQSKLKMEDIKEV 630
+L E + E K++ + +L++ EE E+ Q + + + + ++++ E
Sbjct: 1861 ILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATES 1920
Query: 631 NQAL 634
N+A+
Sbjct: 1921 NEAM 1924
Score = 63.5 bits (153), Expect = 6e-10
Identities = 73/378 (19%), Positives = 168/378 (44%), Gaps = 25/378 (6%)
Query: 263 DANLCLKGEDLDSQVGVIDFSLYLKDVQDLDGGKE-----HERITDVLD---QKNYVEEL 314
DA L L+ ++ + G + L +D Q+ + ++ HE T++ D Q+
Sbjct: 1567 DAKLRLE-VNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAA 1625
Query: 315 NRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQLREQNELI------R 368
+ L + DL+ + D K + ++L ++ Q E + R + I
Sbjct: 1626 KKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKEN 1685
Query: 369 ERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLKEEKKVRLELEKELELQIGMK 428
E+ KS+E + +L ++ R+ D ++ ++L R L+ E K
Sbjct: 1686 EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDE-------K 1738
Query: 429 TEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQKNEAITSFE 488
+E + LE++ E+Q + A+ ++ + Q+ ++ S+ Q+ A E
Sbjct: 1739 RRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE 1798
Query: 489 GKTNQVMSSMKQMEERLQHSERARQGA-EERSHKLQQELGGRIGALQLQLSQLHEQCSSL 547
+ ++ S + +ME ++ ++ A E + +L++++ Q L ++ L
Sbjct: 1799 RQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKL 1858
Query: 548 EKEL-KSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKELRELQDEKAELQKICEEQ 606
++ L + E E++ A Q + Q EK + + +++ +Q+E ++E + + + +LQ+ +E
Sbjct: 1859 KEILLQVEDERKMAEQYKEQAEKGNARVKQLK-RQLEEAEEESQRINANRRKLQRELDEA 1917
Query: 607 EQALQEMGLHLSQSKLKM 624
++ + MG ++ K K+
Sbjct: 1918 TESNEAMGREVNALKSKL 1935
Score = 60.8 bits (146), Expect = 4e-09
Identities = 82/398 (20%), Positives = 171/398 (42%), Gaps = 74/398 (18%)
Query: 308 KNYVEELNRHLSCTVGDLQTKIDGLEKTNS-------KLQEELSAATDRICSLQEEQQQL 360
K VE + L V +LQ+K E+ + KLQ E+ + T + + + +L
Sbjct: 1254 KQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKL 1313
Query: 361 REQNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLKEEKKVRLELEKE 420
+ + + + + E+ +++T+ +L + RQ L+E + + QL EE + + LE+
Sbjct: 1314 AKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ-LEEERNSLQDQLDEEMEAKQNLERH 1372
Query: 421 L-----ELQIGMKTEMEIA--MKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQNA 473
+ +L K + A ++ LE+ Q + L QQ EE A + K +
Sbjct: 1373 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAA----YDKLEKT 1428
Query: 474 ESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQH-------------SERARQGAE---- 516
++ LQQ+ + + Q++S++++ + + ER R AE
Sbjct: 1429 KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1488
Query: 517 ---------------------ERSHKL----QQELGGRIGALQLQLSQLHEQCSSLEKEL 551
ER++K+ ++L + + +L + +LE ++
Sbjct: 1489 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM 1548
Query: 552 KSEKEQRQALQRELQHEKDTSSLLRMELQQVEG-----LKKELRELQDEKAELQKICEEQ 606
+ K Q + L+ ELQ +D L + +Q ++G L+ + ++++ +LQ+ E
Sbjct: 1549 EEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEY 1608
Query: 607 EQALQE---MGLHLSQSKLKME-DIKEV----NQALKG 636
E L++ + +K K+E D+K++ + A+KG
Sbjct: 1609 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKG 1646
Score = 54.3 bits (129), Expect = 4e-07
Identities = 43/218 (19%), Positives = 101/218 (46%), Gaps = 9/218 (4%)
Query: 429 TEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQKNEAITSFE 488
T E M+ E + + ++ +L+E++ + Q+ + + LQ + E E
Sbjct: 855 TRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAE 914
Query: 489 GKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGGRIGALQLQLSQLHEQCSSLE 548
++ + +++EE L E + E+R +LQ E ++ L L + E+ +
Sbjct: 915 EMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAE-RKKMAQQMLDLEEQLEEEEAAR 973
Query: 549 KELKSEKEQRQALQRELQHE----KDTSSLLRMEL----QQVEGLKKELRELQDEKAELQ 600
++L+ EK +A ++L+ E D ++ L E +++ L L E +++ L
Sbjct: 974 QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1033
Query: 601 KICEEQEQALQEMGLHLSQSKLKMEDIKEVNQALKGHA 638
K+ + E + E+ + L + + ++++++ + L+G A
Sbjct: 1034 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDA 1071
Score = 32.3 bits (72), Expect = 1.6
Identities = 20/78 (25%), Positives = 40/78 (51%)
Query: 550 ELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKELRELQDEKAELQKICEEQEQA 609
++ ++E+ QA + ELQ K+ EL+++E +L E ++ E + E
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912
Query: 610 LQEMGLHLSQSKLKMEDI 627
+EM + L+ K ++E+I
Sbjct: 913 AEEMRVRLAAKKQELEEI 930
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 87.8 bits (216), Expect = 3e-17
Identities = 105/451 (23%), Positives = 194/451 (43%), Gaps = 73/451 (16%)
Query: 218 KKLADYLKVLIDNKHLLSEFYEPEALMMEEEGMVIVGLLVGLNVLDANLCLKGEDLDSQV 277
KKL D + V+ D + LS+ E ++EE + L NL +S +
Sbjct: 981 KKLEDEILVMDDQNNKLSK----ERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI 1036
Query: 278 GVIDFSLYLKDVQDLDGGKEHERITDVLDQ-KNYVEELNRHLSCTVGDLQTKIDGLEKTN 336
++ L K+ E+ L++ K +E + DLQ +I L+
Sbjct: 1037 SELEVRL-----------KKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQL 1085
Query: 337 SKLQEELSAATDRICSLQEEQQQLREQNELIRERSEKSVEITKQDTKVELETYKQTRQGL 396
+K +EEL AA R+ ++ ++N +++ E I+ D + +L++ + R
Sbjct: 1086 AKKEEELQAALARL------DDEIAQKNNALKKIRELEGHIS--DLQEDLDSERAARNKA 1137
Query: 397 DEMYSDVWKQLKEEKKVRLELEKEL-------ELQIGMKTEMEIAMKLLEKDT--HEKQ- 446
++ D+ ++L+ ++ ELE L EL+ + E+ + K L+++T HE Q
Sbjct: 1138 EKQKRDLGEELEA---LKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQV 1194
Query: 447 --------DTLVALRQQLEEVKAINLQMFHKAQNAESS-------LQQKNEAITSFEGKT 491
+ L +QLE+ K + Q E L+ +A E K
Sbjct: 1195 QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKK 1254
Query: 492 NQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGGRIGALQLQLSQLHEQCSSLEKEL 551
++ + +++++ + ERAR ++ HKLQ E+ G L++ + L K++
Sbjct: 1255 KKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG----MLNEAEGKAIKLAKDV 1310
Query: 552 KSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKELRELQDEKAELQKICEEQEQALQ 611
S Q Q DT LL+ E +Q + +LR+L++E+ LQ +E+ +A Q
Sbjct: 1311 ASLSSQLQ----------DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQ 1360
Query: 612 EMGLH-------LSQSKLKMEDIKEVNQALK 635
+ H LS SK K++D +AL+
Sbjct: 1361 NLERHISTLNIQLSDSKKKLQDFASTVEALE 1391
Score = 77.0 bits (188), Expect = 5e-14
Identities = 74/329 (22%), Positives = 155/329 (47%), Gaps = 35/329 (10%)
Query: 325 LQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQ--------------QLREQNELIRER 370
L TK+ L + ++ +EE+ A D + +E QQ QL E+ L++E+
Sbjct: 837 LFTKVKPLLQV-TRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 895
Query: 371 SEKSVEI--TKQDTKVELETYKQ-TRQGLDEMYS------DVWKQLKEEKK----VRLEL 417
+ E+ ++ +V L KQ + L EM + D +QL+ E+K L+L
Sbjct: 896 LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 955
Query: 418 EKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQNAESSL 477
E++LE + + ++++ E + +D ++ + Q ++ + + + ++L
Sbjct: 956 EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNL 1015
Query: 478 QQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGGRIGALQLQL 537
++ E + N+ S + ++E RL+ E++RQ E KL+++L G Q+
Sbjct: 1016 AEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE----KLKRKLEGDASDFHEQI 1071
Query: 538 SQLHEQCSSLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKELRELQDEKA 597
+ L Q + L+ +L ++E+ QA L E + +++++EG +L+E D +
Sbjct: 1072 ADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSER 1131
Query: 598 ELQKICEEQEQALQEMGLHLSQSKLKMED 626
+ E+Q+ +++G L K ++ED
Sbjct: 1132 AARNKAEKQK---RDLGEELEALKTELED 1157
Score = 73.9 bits (180), Expect = 5e-13
Identities = 77/318 (24%), Positives = 150/318 (47%), Gaps = 55/318 (17%)
Query: 324 DLQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQLREQNELIRERSEKSVEI--TKQD 381
++Q K D L+KT + Q+ A + + L+++ QL E+ L++E+ + E+ ++
Sbjct: 853 EMQAKEDELQKTKERQQK----AENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE 908
Query: 382 TKVELETYKQTRQGLDEMYSDVWKQLKEEKKVRLELEKELELQIGMKTEMEIAMKLLEKD 441
+V L KQ L+E+ ++ +L+EE+ +L+ E + ++A ++L+
Sbjct: 909 MRVRLAAKKQE---LEEILHEMEARLEEEEDRGQQLQAERK---------KMAQQMLD-- 954
Query: 442 THEKQDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQKNEAITSFEGKTNQVMSSMKQM 501
L +QLEE +A ++ + AE+ +++ + I + + N++ K +
Sbjct: 955 ----------LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLL 1004
Query: 502 EERLQHSERARQGAEERSHKLQQELGGRIGALQLQLSQLHE-QCSSLEKELKSEKEQRQA 560
EER+ EE++ L +L HE S LE LK E++ RQ
Sbjct: 1005 EERISDLTTNLAEEEEKAKNL------------TKLKNKHESMISELEVRLKKEEKSRQE 1052
Query: 561 LQR-ELQHEKDTSSLLRMELQQVEGLKKELRELQDEKAELQKICEEQEQALQEMGLHLSQ 619
L++ + + E D S +Q+ L+ ++ EL K +L K EE + AL + ++Q
Sbjct: 1053 LEKLKRKLEGDASDF----HEQIADLQAQIAEL---KMQLAKKEEELQAALARLDDEIAQ 1105
Query: 620 SKLKMEDIKEVNQALKGH 637
++ I+E L+GH
Sbjct: 1106 KNNALKKIRE----LEGH 1119
Score = 72.8 bits (177), Expect = 1e-12
Identities = 89/364 (24%), Positives = 161/364 (44%), Gaps = 60/364 (16%)
Query: 303 DVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQLRE 362
D++ K+ V + L + L+T+++ ++ +L++EL A D L+ Q L+
Sbjct: 1515 DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG 1574
Query: 363 QNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLKEEKKVRLELE-KEL 421
Q E + ++ E ++ + +L Y+ + DE + L K +LE + K+L
Sbjct: 1575 QFERDLQARDEQNEEKRRQLQRQLHEYETELE--DERKQ---RALAAAAKKKLEGDLKDL 1629
Query: 422 ELQIGMKTE-MEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQK 480
ELQ + E A+K L K + +D +++LE+ +A ++F A+ E
Sbjct: 1630 ELQADSAIKGREEAIKQLRKLQAQMKD----FQRELEDARASRDEIFATAKENEK----- 1680
Query: 481 NEAITSFEGKTNQVMSSMKQMEERLQHSERARQGA----EERSHKLQQELGGRIGALQLQ 536
K + + + Q++E L +ERAR+ A EE + +L L GR ALQ +
Sbjct: 1681 ---------KAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR-NALQDE 1730
Query: 537 LSQLHEQCSSLEKELKSEK--------------EQRQALQRELQHEKDTSSLLRMELQQV 582
+L + + LE+EL+ E+ +Q + L EL E+ T+ QQ+
Sbjct: 1731 KRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQL 1790
Query: 583 EGLKKELRELQDE----------------KAELQKICEEQEQALQEMGLHLSQSKLKMED 626
E KELR E +A++ ++ E+ EQ +E K K +
Sbjct: 1791 ERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKK 1850
Query: 627 IKEV 630
+KE+
Sbjct: 1851 LKEI 1854
Score = 69.7 bits (169), Expect = 9e-12
Identities = 79/398 (19%), Positives = 176/398 (44%), Gaps = 83/398 (20%)
Query: 300 RITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICSLQEE--- 356
R+ + D+ ++ + ++ + DL+ +++ E KLQ E A +I L++E
Sbjct: 930 RLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILV 989
Query: 357 ----QQQLREQNELIRER-SEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLKEEK 411
+L ++ +L+ ER S+ + + +++ K + T + + + M S++ +LK+E+
Sbjct: 990 MDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKH--ESMISELEVRLKKEE 1047
Query: 412 KVRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQ 471
K R ELEK + LE D + + + L+ Q+ E+K +Q+ K +
Sbjct: 1048 KSRQELEK--------------LKRKLEGDASDFHEQIADLQAQIAELK---MQLAKKEE 1090
Query: 472 NAESSLQQKNEAITSFEGKTNQVMSSMKQMEER---LQHSERARQGAEERSHKLQQELGG 528
+++L + ++ I + N + ++++E LQ + + A ++ K +++LG
Sbjct: 1091 ELQAALARLDDEIA----QKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1146
Query: 529 RIGALQLQLSQLHEQCSSLEKELKSEKEQ-----RQALQRELQ-HEKDTSSLLRMELQQV 582
+ AL+ +L + ++ ++EL++++EQ ++AL E + HE + + Q V
Sbjct: 1147 ELEALKTELEDTLDSTAT-QQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAV 1205
Query: 583 EGLKKELRELQDEKA------------------------------------------ELQ 600
E L ++L + + KA ELQ
Sbjct: 1206 EELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1265
Query: 601 KICEEQEQALQEMGLHLSQSKLKMEDIKEVNQALKGHA 638
C + E+A E+ + + + ++E + + +G A
Sbjct: 1266 SKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1303
Score = 66.2 bits (160), Expect = 1e-10
Identities = 72/364 (19%), Positives = 172/364 (47%), Gaps = 31/364 (8%)
Query: 288 DVQDLDGGKEHERITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAAT 347
++Q L G + ER D++N EE R L + + +T+++ K Q L+AA
Sbjct: 1568 NMQALKG--QFERDLQARDEQN--EEKRRQLQRQLHEYETELEDERK-----QRALAAAA 1618
Query: 348 DRICSLQEEQQQLREQ-NELIRERSEKSVEITK-----QDTKVELETYKQTRQGLDEMYS 401
+ L+ + + L Q + I+ R E ++ K +D + ELE + +R DE+++
Sbjct: 1619 KK--KLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASR---DEIFA 1673
Query: 402 DVWKQLKEEKKVR---LELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEE 458
+ K+ K + ++L+++L + + ++ + L ++ AL+ +
Sbjct: 1674 TAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRR 1733
Query: 459 VKAINLQMFHKAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEER 518
++A Q+ + + + +++ ++ + + Q+ + + Q +E ARQ E +
Sbjct: 1734 LEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQ 1793
Query: 519 SHKLQQELGGRIGALQLQ----LSQLHEQCSSLEKELKSEKEQRQALQREL-QHEKDTSS 573
+ +L+ +L GA++ + ++ L + + LE++++ E ++QA + L Q +K
Sbjct: 1794 NKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKE 1853
Query: 574 LLRM---ELQQVEGLKKELRELQDEKAELQKICEEQEQALQEMGLHLSQSKLKMEDIKEV 630
+L E + E K++ + +L++ EE E+ Q + + + + ++++ E
Sbjct: 1854 ILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATES 1913
Query: 631 NQAL 634
N+A+
Sbjct: 1914 NEAM 1917
Score = 63.5 bits (153), Expect = 6e-10
Identities = 73/378 (19%), Positives = 168/378 (44%), Gaps = 25/378 (6%)
Query: 263 DANLCLKGEDLDSQVGVIDFSLYLKDVQDLDGGKE-----HERITDVLD---QKNYVEEL 314
DA L L+ ++ + G + L +D Q+ + ++ HE T++ D Q+
Sbjct: 1560 DAKLRLE-VNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAA 1618
Query: 315 NRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQLREQNELI------R 368
+ L + DL+ + D K + ++L ++ Q E + R + I
Sbjct: 1619 KKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKEN 1678
Query: 369 ERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLKEEKKVRLELEKELELQIGMK 428
E+ KS+E + +L ++ R+ D ++ ++L R L+ E K
Sbjct: 1679 EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDE-------K 1731
Query: 429 TEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQKNEAITSFE 488
+E + LE++ E+Q + A+ ++ + Q+ ++ S+ Q+ A E
Sbjct: 1732 RRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE 1791
Query: 489 GKTNQVMSSMKQMEERLQHSERARQGA-EERSHKLQQELGGRIGALQLQLSQLHEQCSSL 547
+ ++ S + +ME ++ ++ A E + +L++++ Q L ++ L
Sbjct: 1792 RQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKL 1851
Query: 548 EKEL-KSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKELRELQDEKAELQKICEEQ 606
++ L + E E++ A Q + Q EK + + +++ +Q+E ++E + + + +LQ+ +E
Sbjct: 1852 KEILLQVEDERKMAEQYKEQAEKGNARVKQLK-RQLEEAEEESQRINANRRKLQRELDEA 1910
Query: 607 EQALQEMGLHLSQSKLKM 624
++ + MG ++ K K+
Sbjct: 1911 TESNEAMGREVNALKSKL 1928
Score = 60.8 bits (146), Expect = 4e-09
Identities = 82/398 (20%), Positives = 171/398 (42%), Gaps = 74/398 (18%)
Query: 308 KNYVEELNRHLSCTVGDLQTKIDGLEKTNS-------KLQEELSAATDRICSLQEEQQQL 360
K VE + L V +LQ+K E+ + KLQ E+ + T + + + +L
Sbjct: 1247 KQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKL 1306
Query: 361 REQNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLKEEKKVRLELEKE 420
+ + + + + E+ +++T+ +L + RQ L+E + + QL EE + + LE+
Sbjct: 1307 AKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ-LEEERNSLQDQLDEEMEAKQNLERH 1365
Query: 421 L-----ELQIGMKTEMEIA--MKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQNA 473
+ +L K + A ++ LE+ Q + L QQ EE A + K +
Sbjct: 1366 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAA----YDKLEKT 1421
Query: 474 ESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQH-------------SERARQGAE---- 516
++ LQQ+ + + Q++S++++ + + ER R AE
Sbjct: 1422 KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1481
Query: 517 ---------------------ERSHKL----QQELGGRIGALQLQLSQLHEQCSSLEKEL 551
ER++K+ ++L + + +L + +LE ++
Sbjct: 1482 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM 1541
Query: 552 KSEKEQRQALQRELQHEKDTSSLLRMELQQVEG-----LKKELRELQDEKAELQKICEEQ 606
+ K Q + L+ ELQ +D L + +Q ++G L+ + ++++ +LQ+ E
Sbjct: 1542 EEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEY 1601
Query: 607 EQALQE---MGLHLSQSKLKME-DIKEV----NQALKG 636
E L++ + +K K+E D+K++ + A+KG
Sbjct: 1602 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKG 1639
Score = 54.3 bits (129), Expect = 4e-07
Identities = 43/218 (19%), Positives = 101/218 (46%), Gaps = 9/218 (4%)
Query: 429 TEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQKNEAITSFE 488
T E M+ E + + ++ +L+E++ + Q+ + + LQ + E E
Sbjct: 848 TRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAE 907
Query: 489 GKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGGRIGALQLQLSQLHEQCSSLE 548
++ + +++EE L E + E+R +LQ E ++ L L + E+ +
Sbjct: 908 EMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAE-RKKMAQQMLDLEEQLEEEEAAR 966
Query: 549 KELKSEKEQRQALQRELQHE----KDTSSLLRMEL----QQVEGLKKELRELQDEKAELQ 600
++L+ EK +A ++L+ E D ++ L E +++ L L E +++ L
Sbjct: 967 QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1026
Query: 601 KICEEQEQALQEMGLHLSQSKLKMEDIKEVNQALKGHA 638
K+ + E + E+ + L + + ++++++ + L+G A
Sbjct: 1027 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDA 1064
Score = 32.3 bits (72), Expect = 1.6
Identities = 20/78 (25%), Positives = 40/78 (51%)
Query: 550 ELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKELRELQDEKAELQKICEEQEQA 609
++ ++E+ QA + ELQ K+ EL+++E +L E ++ E + E
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 905
Query: 610 LQEMGLHLSQSKLKMEDI 627
+EM + L+ K ++E+I
Sbjct: 906 AEEMRVRLAAKKQELEEI 923
>gi|46593000 GRIP1 associated protein 1 isoform 2 [Homo sapiens]
Length = 625
Score = 87.4 bits (215), Expect = 4e-17
Identities = 91/367 (24%), Positives = 167/367 (45%), Gaps = 24/367 (6%)
Query: 286 LKDVQDLDGGKEHERITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSA 345
LK Q+ + E+ T D +N +EEL + D + ++ KLQ+EL A
Sbjct: 182 LKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEA---DHKAQL----ARTQKLQQELEA 234
Query: 346 ATDRICSLQEEQQQLREQNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWK 405
A + L++++Q R ++ + V I D + ++E L + + +
Sbjct: 235 ANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAAL-E 293
Query: 406 QLKEEKKVRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQ 465
Q++ K L + +E G+ E++ E +K D L++ L + Q
Sbjct: 294 QIQTAKTQELNMLREQTT--GLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQ 351
Query: 466 MFHKAQNAESSLQQKNEAITSFEGKTNQVMS-SMKQMEERLQHSERARQGAEERSHKLQQ 524
+ Q E Q+ EA S E + + +M+ ++E+ QH E GA H ++
Sbjct: 352 LQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEEL--GAVRLRH--EK 407
Query: 525 ELGGRIGALQLQLSQLHEQCSSLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEG 584
E+ G + +L +LHE E+EL+ + + +A REL+ + T L+ ++ ++G
Sbjct: 408 EVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDG 467
Query: 585 LK----KELRELQDEKAELQKICEEQEQALQEMGLHL---SQSKLKMEDIKEVNQAL--K 635
K + L+E + ++ ELQ + ++ EQA +E HL S K +++D + + L K
Sbjct: 468 AKGWFERRLKEAEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKK 527
Query: 636 GHAWLKD 642
G A LKD
Sbjct: 528 GSAALKD 534
Score = 54.3 bits (129), Expect = 4e-07
Identities = 68/292 (23%), Positives = 131/292 (44%), Gaps = 39/292 (13%)
Query: 309 NYVEELNRHLSCTVGDLQTKIDGL----EKTNSKLQEELSAATDRICSLQE---EQQQLR 361
N + E L+ + Q + + L + NS+LQE L A + + LQE E++QL
Sbjct: 304 NMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLT 363
Query: 362 EQNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLKEEKKVRLELEKEL 421
++ + R+ +EK + + + +ET ++ Q +E+ + VRL EKE+
Sbjct: 364 QELQEARKSAEKRKAMLDE---LAMETLQEKSQHKEELGA-----------VRLRHEKEV 409
Query: 422 ELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQKN 481
+G++ E ++ L +D +++ LR Q+ E KA ++ Q E LQ +
Sbjct: 410 ---LGVRARYERELRELHEDKKRQEE---ELRGQIREEKARTRELETLQQTVE-ELQAQV 462
Query: 482 EAITSFEGKTNQVMSSMKQMEERLQH-SERARQGAEERS------HKLQQELGGRIGALQ 534
++ +G + + + EE LQ ++ Q EER L+QE+ + +
Sbjct: 463 HSMDGAKGWFERRLKEAEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQR 522
Query: 535 LQLSQLHEQCSSLEKELKSEKEQRQALQRELQ----HEKDTSSLLRMELQQV 582
+ + L+++L E+++ LQ LQ + K S L + L ++
Sbjct: 523 ILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSRSGLEELVLSEM 574
Score = 45.4 bits (106), Expect = 2e-04
Identities = 67/268 (25%), Positives = 118/268 (44%), Gaps = 38/268 (14%)
Query: 352 SLQEEQQQLREQNELIRERS---EKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLK 408
+L EE+ Q R Q +L+ R+ + S E+ K VEL + +Q LD+ +S K L
Sbjct: 4 ALSEEEFQ-RMQAQLLELRTNNYQLSDELRKNG--VELTSLRQKVAYLDKEFSKAQKALS 60
Query: 409 EEKKVRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFH 468
+ KK +E+E+ + ++ + E+D + TL+A + + +
Sbjct: 61 KSKKA-----QEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMA---------EFSKERYG 106
Query: 469 KAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGG 528
K S++ + G V++ M E L+ + +E L ++L G
Sbjct: 107 KEAGKFSAVSEGQGDPPG--GPAPTVLAPMPLAEVELKW-----EMEKEEKRLLWEQLQG 159
Query: 529 RIGALQLQLSQLHEQCSSLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKE 588
+ Q + S+L E+ + L ++LK ++E LQ E + + S ELQQ
Sbjct: 160 LESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQ------- 212
Query: 589 LRELQDEKAEL---QKICEEQEQALQEM 613
R+ D KA+L QK+ +E E A Q +
Sbjct: 213 -RKEADHKAQLARTQKLQQELEAANQSL 239
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 86.7 bits (213), Expect = 7e-17
Identities = 122/547 (22%), Positives = 230/547 (42%), Gaps = 69/547 (12%)
Query: 168 GQNKSFF--GPLELVEKLCPEA-SDIATSVRNLP-------ELKTAVGRGRA-----WLY 212
G K FF G L L+E++ E S I T ++ E K V R A W
Sbjct: 761 GHTKVFFKAGLLGLLEEMRDERLSRIITRMQAQARGQLMRIEFKKIVERRDALLVIQWNI 820
Query: 213 LALMQKKLADYLKVLIDNKHLL--SEFYEPEALMMEEEGMV-----------------IV 253
A M K ++K+ K LL +E + A M EE G + +V
Sbjct: 821 RAFMGVKNWPWMKLYFKIKPLLKSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMV 880
Query: 254 GLLVGLNVLDANLCLKGEDLDSQVGVIDFSLYLKDVQDLDGGKEHERITDVLDQKNYVEE 313
LL N L + + ++L+ D + K + + +ER+ D + +
Sbjct: 881 SLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTA 940
Query: 314 LNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQLREQNELIRERSEK 373
R L +L+ ID LE T +K+++E A +++ +L EE L E + + +
Sbjct: 941 KKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKA 1000
Query: 374 SVEITKQ---DTKVE---LETYKQTRQGLDEMYSDVWKQLKEEKKVRLELEKELELQIGM 427
E +Q D +VE + + +++ L++ D+ L++EKKVR++LE+
Sbjct: 1001 LQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLER-------- 1052
Query: 428 KTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQKNEAITSF 487
A + LE D Q++++ L LQ+ K + E + Q+N I
Sbjct: 1053 ------AKRKLEGDLKLTQESIMDLEND-------KLQLEEKLKKKEFDINQQNSKIEDE 1099
Query: 488 EGKTNQVMSSMKQMEERLQHSER---ARQGAEERSHKLQQELGGRIGALQLQLSQLHEQC 544
+ Q+ +K+ + R++ E A + A + KL+ +L + + +L +
Sbjct: 1100 QVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGAT 1159
Query: 545 S-----SLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKELRELQDEKAEL 599
S + ++E + +K +R + LQHE ++L + V L +++ LQ K +L
Sbjct: 1160 SVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKL 1219
Query: 600 QKICEEQEQALQEMGLHLSQSKLKMEDIKEVNQALKGHAWLKDDEATHCRQCEKEFSISR 659
+K E + L ++ ++ Q ++++V++ L+ A + ++ +F+ R
Sbjct: 1220 EKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQR 1279
Query: 660 RKHHCRN 666
K N
Sbjct: 1280 AKLQTEN 1286
Score = 72.0 bits (175), Expect = 2e-12
Identities = 91/407 (22%), Positives = 182/407 (44%), Gaps = 75/407 (18%)
Query: 302 TDVLDQKNYVEELNRHLSCTVGDLQ-------TKIDGLEKTNSKLQEEL----------- 343
TD + + +EE + L+ + D + K LEKT +LQ E+
Sbjct: 1379 TDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSN 1438
Query: 344 --SAATDR----ICSLQEEQQQLREQNELIRERSEK-----SVEITK-----QDTKVELE 387
+AA D+ + E +Q E+++ E S+K S E+ K +++ LE
Sbjct: 1439 AAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLE 1498
Query: 388 TYKQTRQGLDEMYSDVWKQLKEEKKVRLELE---KELELQIGMKTEMEIAMKLLEKDTHE 444
T+K+ + L E SD+ +QL E K ELE K+LE++ K E++ A++ E
Sbjct: 1499 TFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVE---KLELQSALEEAEASLEH 1555
Query: 445 KQDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEER 504
++ ++ + + ++KA E L +K+E M K+ +R
Sbjct: 1556 EEGKILRAQLEFNQIKA----------EIERKLAEKDEE-----------MEQAKRNHQR 1594
Query: 505 LQHSERARQGAEERSH----KLQQELGGRIGALQLQLSQLHEQCSSLEKELKSEKEQRQA 560
+ S + AE RS ++++++ G + +++QLS + + +K++KS Q+
Sbjct: 1595 VVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKS----LQS 1650
Query: 561 LQRELQHEKDTSSLLRMELQQ-VEGLKKELRELQDEKAELQKICEEQEQALQEMGLHLSQ 619
L ++ Q + D + +L++ + +++ LQ E EL+ + E+ E++ + L +
Sbjct: 1651 LLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIE 1710
Query: 620 SKLKMEDIKEVNQALKGHAWLKDDEATHCRQCEKEFSISRRKHHCRN 666
+ +++ + N +L + + T Q E E ++ CRN
Sbjct: 1711 TSERVQLLHSQNTSLINQKKKMESDLTQL-QSEVEEAV----QECRN 1752
Score = 68.6 bits (166), Expect = 2e-11
Identities = 106/506 (20%), Positives = 213/506 (42%), Gaps = 77/506 (15%)
Query: 180 VEKLCPEASDIATSVRNLPELKTAVGRGRAWLYLALMQKKLADYLKVLIDNKHLLSEFYE 239
VEKL SD++ + + E G G + + + +K+ A++ K+ D + +
Sbjct: 1134 VEKL---RSDLSRELEEISERLEEAG-GATSVQIEMNKKREAEFQKMRRDLEEATLQHEA 1189
Query: 240 PEALMMEEEGMVIVGLLVGLNVLDANLCLKGEDLDSQVGVIDFSLYLKDVQDLDGGKEHE 299
A + ++ + L ++ NL + L+ + +F L L DV
Sbjct: 1190 TAAALRKKHADSVAELGEQID----NLQRVKQKLEKEKS--EFKLELDDVTS-------- 1235
Query: 300 RITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICSLQEEQ-- 357
+ ++ K +E+++R L + + K++ + Q L+ T + LQ E
Sbjct: 1236 NMEQIIKAKANLEKVSRTLEDQANEYRVKLE-------EAQRSLNDFTTQRAKLQTENGE 1288
Query: 358 --QQLREQNELIRERSEKSVEITKQ--DTKVELETYKQTRQGLDEMYSD-------VWKQ 406
+QL E+ LI + + + T+Q D K +LE + + L + +Q
Sbjct: 1289 LARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQ 1348
Query: 407 LKEEKKVRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQM 466
+EE + + EL++ L K E+A + +T Q T ++LEE K ++
Sbjct: 1349 YEEETEAKAELQRVLS-----KANSEVAQWRTKYETDAIQRT-----EELEEAKK---KL 1395
Query: 467 FHKAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEERSH---KLQ 523
+ Q+AE +++ N +S E +++ + ++ + ++ S A +++ K+
Sbjct: 1396 AQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKIL 1455
Query: 524 QELGGRIGALQLQLSQLHEQCSSLEKEL-------KSEKEQRQALQRELQHEKDTSSLLR 576
E + Q +L ++ SL EL + E + +RE ++ ++ S L
Sbjct: 1456 AEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLT 1515
Query: 577 MEL----QQVEGLKKELRELQDEKAELQKICEEQEQALQEMGLHLSQSKLKMEDIK---- 628
+L + V L+K ++L+ EK ELQ EE E +L+ + +++L+ IK
Sbjct: 1516 EQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIE 1575
Query: 629 --------EVNQALKGHAWLKDDEAT 646
E+ QA + H + D T
Sbjct: 1576 RKLAEKDEEMEQAKRNHQRVVDSLQT 1601
Score = 65.1 bits (157), Expect = 2e-10
Identities = 74/356 (20%), Positives = 170/356 (47%), Gaps = 41/356 (11%)
Query: 306 DQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEEL----SAATDRICSLQEEQQQ-L 360
+ KN EE++ L+ +G+ + LEK +L+ E SA + SL+ E+ + L
Sbjct: 1503 ENKNLQEEIS-DLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKIL 1561
Query: 361 REQNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLKEEKKVRLELEKE 420
R Q E + ++E ++ ++D ++E + + ++ +D + + + + + +V L ++K+
Sbjct: 1562 RAQLEFNQIKAEIERKLAEKDEEME-QAKRNHQRVVDSLQTSLDAETRSRNEV-LRVKKK 1619
Query: 421 LELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQK 480
+E G EMEI + + E Q + +L+ L++ + + +A +
Sbjct: 1620 ME---GDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQI-------QLDDAVRANDDL 1669
Query: 481 NEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAE----ERSHKLQ------------- 523
E I E + N + + ++++ ++ +ER+R+ AE E S ++Q
Sbjct: 1670 KENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQK 1729
Query: 524 QELGGRIGALQLQLSQLHEQCSSLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQVE 583
+++ + LQ ++ + ++C + E++ K + EL+ E+DTS+ L + +E
Sbjct: 1730 KKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNME 1789
Query: 584 GLKKELRELQDEKAEL-----QKICEEQEQALQEMGLHL-SQSKLKMEDIKEVNQA 633
K+L+ DE ++ +K ++ E ++E+ L ++ K E +K + ++
Sbjct: 1790 QTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKS 1845
Score = 59.7 bits (143), Expect = 9e-09
Identities = 80/362 (22%), Positives = 154/362 (42%), Gaps = 45/362 (12%)
Query: 311 VEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQLREQNELIRER 370
+E+ R+ V LQT +D +T S+ E L L E + QL N + E
Sbjct: 1585 MEQAKRNHQRVVDSLQTSLDA--ETRSR-NEVLRVKKKMEGDLNEMEIQLSHANRMAAEA 1641
Query: 371 SE--KSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLKEEKKVRLELEKELELQIGMK 428
+ KS++ +DT+++L+ + L E + V E++ L L+ ELE +
Sbjct: 1642 QKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIV------ERRNNL-LQAELEELRAVV 1694
Query: 429 TEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQKNEAITSFE 488
+ E + KL E++ E + + L Q + +M +S +++ + + E
Sbjct: 1695 EQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAE 1754
Query: 489 GKTNQVMSSMKQMEERLQ-------HSERARQGAEERSHKLQQELGGR----IGALQLQL 537
K + ++ M E L+ H ER ++ E+ LQ L + + QL
Sbjct: 1755 EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQL 1814
Query: 538 SQLHEQCSSLEKELKSE------------KEQRQALQRELQHEKDTSSLLRME-----LQ 580
+L + LE EL++E K +R+ + Q E+D +LLR++ LQ
Sbjct: 1815 QKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLLRLQDLVDKLQ 1874
Query: 581 -QVEGLKKELRELQDEK----AELQKICEEQEQALQEMGLHLSQSKLKMEDIKEVNQALK 635
+V+ K++ E +++ ++ +K+ E ++A + + SQ +++ K
Sbjct: 1875 LKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGAKQK 1934
Query: 636 GH 637
H
Sbjct: 1935 MH 1936
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 86.3 bits (212), Expect = 9e-17
Identities = 79/356 (22%), Positives = 180/356 (50%), Gaps = 40/356 (11%)
Query: 300 RITDVLDQKNYVEELN-------RHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICS 352
+I +V ++ EE+N R L +L+ ID LE T +K+++E A +++ +
Sbjct: 922 KIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKN 981
Query: 353 LQEEQQQLREQ-NELIRERS--EKSVEITKQDTKVE---LETYKQTRQGLDEMYSDVWKQ 406
L EE L E +L +E+ +++ + T D + E + T + + L++ D+
Sbjct: 982 LTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGS 1041
Query: 407 LKEEKKVRLELEK-----ELELQIGMKTEMEIA--MKLLEKDTHEKQDTLVALRQQLEEV 459
L++EKK+R++LE+ E +L++ ++ M+I + L++ +K+ + L+ ++E+
Sbjct: 1042 LEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDE 1101
Query: 460 KAINLQMFHKAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEERS 519
+A+ +Q+ K + ++ +++ E I + + + Q S+ +R+ EE S
Sbjct: 1102 QALGMQLQKKIKELQARIEELEEEIEA---------ERASRAKAEKQRSDLSRE-LEEIS 1151
Query: 520 HKLQQELGGRIGALQLQLSQLHEQCSSLEKELKSEKEQRQALQRELQHEKDTSSLLRMEL 579
+L+ E GG A Q+++++ ++E + +K +R + LQHE ++L +
Sbjct: 1152 ERLE-EAGGATSA-QIEMNK--------KREAEFQKMRRDLEEATLQHEATAATLRKKHA 1201
Query: 580 QQVEGLKKELRELQDEKAELQKICEEQEQALQEMGLHLSQSKLKMEDIKEVNQALK 635
V L +++ LQ K +L+K E + + ++ ++ +++++ +AL+
Sbjct: 1202 DSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALE 1257
Score = 66.6 bits (161), Expect = 7e-11
Identities = 75/375 (20%), Positives = 163/375 (43%), Gaps = 55/375 (14%)
Query: 299 ERITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICSLQ-EEQ 357
E+I ++ K +E+ + + DL + ++ + K L++ A D++ ++ +E+
Sbjct: 1209 EQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEE 1268
Query: 358 QQLREQNELIRERS-------EKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLKEE 410
+Q R N+L +R+ E S ++ ++DT V + +Q + ++ +QL+EE
Sbjct: 1269 EQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVS--QLSRGKQAFTQQIEELKRQLEEE 1326
Query: 411 KKVRLEL----------------------EKELELQIGM-KTEMEIAMKLLEKDTHEKQD 447
K + L E + ELQ M K E+A + +T Q
Sbjct: 1327 IKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQR 1386
Query: 448 TLVALRQQLEEVKAINLQMFHKAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQH 507
T ++LEE K ++ + Q+AE ++ N S E ++ + ++ + ++
Sbjct: 1387 T-----EELEEAKK---KLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVER 1438
Query: 508 SERARQGAEERSHKLQ----------QELGGRIGALQLQLSQLHEQCSSLEKELKSEKEQ 557
+ A +++ +E + A Q + L + ++ + +Q
Sbjct: 1439 TNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQ 1498
Query: 558 RQALQRE---LQHE-KDTSSLLRMELQQVEGLKKELRELQDEKAELQKICEEQEQALQEM 613
+ L+RE LQ E D + + +++ L+K ++++ EK+ELQ EE E +L+
Sbjct: 1499 LETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHE 1558
Query: 614 GLHLSQSKLKMEDIK 628
+ + +L++ +K
Sbjct: 1559 EGKILRIQLELNQVK 1573
Score = 66.2 bits (160), Expect = 1e-10
Identities = 80/378 (21%), Positives = 167/378 (44%), Gaps = 66/378 (17%)
Query: 302 TDVLDQKNYVEELNRHLSCTVGDLQTKIDG-------LEKTNSKLQEELS------AATD 348
TD + + +EE + L+ + D + ++ LEKT +LQ E+ T+
Sbjct: 1381 TDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTN 1440
Query: 349 RICSLQEEQQ-----------QLREQNELIRERSEK-----SVEITK-----QDTKVELE 387
C+ +++Q Q E+ E S+K S E+ K +++ +LE
Sbjct: 1441 AACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLE 1500
Query: 388 TYKQTRQGLDEMYSDVWKQLKEEKKVRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQD 447
T K+ + L + SD+ +Q+ E K ELEK + K+E++ A++ E ++
Sbjct: 1501 TLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEG 1560
Query: 448 TLVALRQQLEEVKAINLQMFHKAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQH 507
++ ++ +L +VK+ + + +K+E I + +++ S M+ L
Sbjct: 1561 KILRIQLELNQVKS----------EVDRKIAEKDEEIDQMKRNHIRIVES---MQSTLDA 1607
Query: 508 SERARQGAEERSHKLQQELGGRIGALQLQLSQLHEQCSSLEKELKSE----KEQRQALQR 563
R+R A +L++++ G + +++QL+ + + + ++ K+ + L
Sbjct: 1608 EIRSRNDA----IRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDD 1663
Query: 564 ELQHEKDTSSLLRMELQQVEGLKKELRELQ---DEKAELQKICE-------EQEQALQEM 613
L+ ++D L M ++ L+ E+ EL+ ++ +KI E E+ Q L
Sbjct: 1664 ALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQ 1723
Query: 614 GLHLSQSKLKME-DIKEV 630
L +K K+E DI ++
Sbjct: 1724 NTSLINTKKKLETDISQI 1741
Score = 64.7 bits (156), Expect = 3e-10
Identities = 81/359 (22%), Positives = 162/359 (45%), Gaps = 47/359 (13%)
Query: 305 LDQKNYVEELNRHLSCTVGDLQT-------KIDGLEKTNSKLQEELS----AATDRICSL 353
LDQ ++ N++L + DL +I LEK ++++E S A + SL
Sbjct: 1496 LDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASL 1555
Query: 354 QEEQQQ-LREQNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLKEEKK 412
+ E+ + LR Q EL + +SE +I ++D +++ R ++ M S + +++
Sbjct: 1556 EHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRI-VESMQSTLDAEIRSRND 1614
Query: 413 VRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQN 472
+ L+K++E G EMEI + H + ALR + H +
Sbjct: 1615 A-IRLKKKME---GDLNEMEIQLN------HANRMAAEALRNYRNTQAILKDTQLH-LDD 1663
Query: 473 AESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEER----SHKLQ----- 523
A S + E + E + N + + ++++ L+ +ER+R+ AE+ S ++Q
Sbjct: 1664 ALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQ 1723
Query: 524 --------QELGGRIGALQLQLSQLHEQCSSLEKELKSEKEQRQALQRELQHEKDTSSLL 575
++L I +Q ++ + ++ + E++ K + EL+ E+DTS+ L
Sbjct: 1724 NTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHL 1783
Query: 576 RMELQQVEGLKKELRELQDEKAEL-----QKICEEQEQALQEM-GLHLSQSKLKMEDIK 628
+ +E K+L+ DE +L +K ++ E ++E+ G S+ K +E +K
Sbjct: 1784 ERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVK 1842
Score = 56.6 bits (135), Expect = 8e-08
Identities = 60/339 (17%), Positives = 138/339 (40%), Gaps = 18/339 (5%)
Query: 324 DLQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQLREQNELIRERSEKSVEITKQDTK 383
D + + LE+ KL + L A + + ++ + L + + ++ E + I + T
Sbjct: 1382 DAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVE-DLMIDVERTN 1440
Query: 384 VELETYKQTRQGLDEMYSDVWKQLKEEKKVRLELEKELELQIGMKTEMEIAMKLLE-KDT 442
+ ++ D++ ++ WKQ EE EL+ K ++ +L + K+
Sbjct: 1441 AACAALDKKQRNFDKILAE-WKQKCEETHA--------ELEASQKESRSLSTELFKIKNA 1491
Query: 443 HEKQDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQKNEAITSFEGKTNQVMSSMKQME 502
+E+ QLE +K N + + + + + + I E QV +++
Sbjct: 1492 YEES------LDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQ 1545
Query: 503 ERLQHSERARQGAEERSHKLQQELGGRIGALQLQLSQLHEQCSSLEKE-LKSEKEQRQAL 561
L+ +E + + E + ++Q EL + ++++ E+ +++ ++ + + L
Sbjct: 1546 AALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTL 1605
Query: 562 QRELQHEKDTSSLLRMELQQVEGLKKELRELQDEKAELQKICEEQEQALQEMGLHLSQSK 621
E++ D L + + ++ +L AE + + L++ LHL +
Sbjct: 1606 DAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDAL 1665
Query: 622 LKMEDIKEVNQALKGHAWLKDDEATHCRQCEKEFSISRR 660
ED+KE ++ A L E R ++ SR+
Sbjct: 1666 RSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRK 1704
Score = 56.2 bits (134), Expect = 1e-07
Identities = 73/341 (21%), Positives = 155/341 (45%), Gaps = 58/341 (17%)
Query: 332 LEKTNSKLQEELSAATDRIC-------SLQEEQQQLREQNELIRE--RSEKSVEITKQDT 382
+E S L E+ + D I L E + QL N + E R+ ++ + +DT
Sbjct: 1598 VESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDT 1657
Query: 383 KVELETYKQTRQGLDEMYSDVWKQLKEEKKVRLELEKELELQIGMKTEMEIAMKLLEKDT 442
++ L+ ++++ L E + V E++ L L+ E+E + E + K+ E++
Sbjct: 1658 QLHLDDALRSQEDLKEQLAMV------ERRANL-LQAEIEELRATLEQTERSRKIAEQEL 1710
Query: 443 ----------HEKQDTLVALRQQLE-EVKAINLQMFHKAQNAESSLQQKNEAITSFEGKT 491
H + +L+ +++LE ++ I +M Q A ++ ++ +AIT
Sbjct: 1711 LDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITD----A 1766
Query: 492 NQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGGR----IGALQLQLSQLHEQCSSL 547
+ +K+ ++ H ER ++ E+ LQ L + + Q+ +L + L
Sbjct: 1767 AMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVREL 1826
Query: 548 EKELKSE------------KEQRQALQRELQHEKDTSSLLRME-----LQ-QVEGLKKEL 589
E E++SE K +R+ + Q E+D ++LR++ LQ +V+ K++
Sbjct: 1827 EGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQA 1886
Query: 590 RELQDEK----AELQKICEEQEQALQEMGLHLSQ-SKLKME 625
E +++ ++ ++I E E+A + + SQ +KL+++
Sbjct: 1887 EEAEEQSNVNLSKFRRIQHELEEAEERADIAESQVNKLRVK 1927
Score = 52.4 bits (124), Expect = 1e-06
Identities = 53/311 (17%), Positives = 139/311 (44%), Gaps = 42/311 (13%)
Query: 333 EKTNSKLQEELSAATDRICSLQEEQQQLREQN-ELIRERSEKSVEITKQ-----DTKVEL 386
EK + ++EE + + + ++++L E+ L++E+++ +++ + D +
Sbjct: 850 EKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEERC 909
Query: 387 ETYKQTRQGLDEMYSDVWKQLKEEKKVRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQ 446
+ +T+ L+ +V ++ ++E+++ EL + K ++E L+KD + +
Sbjct: 910 DQLIKTKIQLEAKIKEVTERAEDEEEINAELTAK-------KRKLEDECSELKKDIDDLE 962
Query: 447 DTLVALRQQLEEVKAINLQMFHKAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQ 506
TL + ++ H +N +L ++ M+ + + +L
Sbjct: 963 LTLAKVEKEK-----------HATENKVKNLTEE--------------MAGLDETIAKLT 997
Query: 507 HSERARQGAEERSHKLQQELGGRIGALQLQLSQLHEQCSSLEKELKSEKEQRQALQRELQ 566
++A Q A +++ Q ++ L +L +Q LE L+ EK+ R L+R +
Sbjct: 998 KEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKR 1057
Query: 567 HEKDTSSLLRMELQQVEG----LKKELRELQDEKAELQKICEEQEQALQEMGLHLSQSKL 622
+ L + +E L ++L++ + E + LQ E+++ ++ + + +
Sbjct: 1058 KLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQA 1117
Query: 623 KMEDIKEVNQA 633
++E+++E +A
Sbjct: 1118 RIEELEEEIEA 1128
Score = 31.2 bits (69), Expect = 3.5
Identities = 25/131 (19%), Positives = 57/131 (43%), Gaps = 15/131 (11%)
Query: 548 EKELKSEKEQRQALQRELQH----EKDTSSLLRMELQQVEGLKKELRELQDEKAELQKIC 603
EKE+ + KE+ + + EL K+ + +Q+ L+ +++ D A+ ++ C
Sbjct: 850 EKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEERC 909
Query: 604 EEQEQALQEMGLHLSQSKLKMEDIKEVNQALKGHAWLKDDEATHCRQCEKEF-------- 655
++ + ++ + + + ED +E+N L +DE C + +K+
Sbjct: 910 DQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDE---CSELKKDIDDLELTLA 966
Query: 656 SISRRKHHCRN 666
+ + KH N
Sbjct: 967 KVEKEKHATEN 977
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 85.5 bits (210), Expect = 2e-16
Identities = 72/316 (22%), Positives = 158/316 (50%), Gaps = 35/316 (11%)
Query: 300 RITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQ 359
R+ + ++ ++ + + + DL+ ++D E KLQ E A +I ++EE
Sbjct: 930 RVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILL 989
Query: 360 LREQN-ELIRER-------SEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLKEEK 411
L +QN + I+E+ +E S ++ +++ K + + R + M SD+ ++LK+E+
Sbjct: 990 LEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKA--KNLAKIRNKQEVMISDLEERLKKEE 1047
Query: 412 KVRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQ 471
K R ELEK A + L+ +T + QD + L+ Q++E+K LQ+ K +
Sbjct: 1048 KTRQELEK--------------AKRKLDGETTDLQDQIAELQAQIDELK---LQLAKKEE 1090
Query: 472 NAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGGRIG 531
+ +L + ++ T + +V+ ++ LQ + + + ++ K +++L +
Sbjct: 1091 ELQGALARGDDE-TLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELE 1149
Query: 532 ALQLQLSQLHEQCSSLEKELKSEKEQ-----RQALQRELQ-HEKDTSSLLRMELQQVEGL 585
AL+ +L + ++ ++EL++++EQ ++AL+ E + HE + + +E L
Sbjct: 1150 ALKTELEDTLD-TTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEEL 1208
Query: 586 KKELRELQDEKAELQK 601
++L + + KA L+K
Sbjct: 1209 SEQLEQAKRFKANLEK 1224
Score = 83.2 bits (204), Expect = 8e-16
Identities = 126/590 (21%), Positives = 233/590 (39%), Gaps = 87/590 (14%)
Query: 145 LQQFFVVMEHCLKHGLKVKKSFIGQNKSFFGPLELVEKLCPEASDIATSVRNLPELKTAV 204
L ++E K G+K K EL+++ + ++++ +R L E K ++
Sbjct: 1289 LDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSL 1348
Query: 205 ---------GRGRAWLYLALMQKKLADYLKVLIDNKHLLSEFYEP--------EALM--M 245
R + +Q +LAD K + D+ + E EAL +
Sbjct: 1349 QEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRL 1408
Query: 246 EEEGMVIVGLLVGLNVLDANLCLKGEDLDSQVGVID--------FSLYLKDVQDLDGGKE 297
EE+ + L N L L DLD Q V F L + + +
Sbjct: 1409 EEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYA 1468
Query: 298 HER--------------------ITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNS 337
ER + + L+ K E N+ L + DL + D + K
Sbjct: 1469 EERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVH 1528
Query: 338 KLQEELSAATDRICSLQEEQQQLREQNELIRERSEKSVEITKQDTKVELETYKQTRQGLD 397
+L++ A ++ ++ + ++L ++ + E ++ +E+ Q K + E QTR +
Sbjct: 1529 ELEKSKRALEQQVEEMRTQLEELEDELQAT-EDAKLRLEVNMQAMKAQFERDLQTRDEQN 1587
Query: 398 EMYSDVWKQLKEEKKVRLELE---KELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQ 454
E + +K+ +++ ELE K+ L + K +MEI +K LE + +
Sbjct: 1588 EEKKRLL--IKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIK 1645
Query: 455 QLEEVKAINLQMFHKAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQG 514
QL +++A + + A +S + E K + + + Q++E L SERAR+
Sbjct: 1646 QLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRH 1705
Query: 515 AEERSHKLQQELGGRI---GALQLQLSQLHEQCSSLEKELKSEKE--------------Q 557
AE+ +L E+ AL + +L + + LE+EL+ E+ Q
Sbjct: 1706 AEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQ 1765
Query: 558 RQALQRELQHEKDTSSLLRMELQQVEGLKKELR-ELQDEKAELQ------------KICE 604
L EL E+ + QQ+E KEL+ +LQ+ + ++ KI +
Sbjct: 1766 VDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQ 1825
Query: 605 EQEQALQEMGLHLSQSKLKMEDIKEVNQALKGHAWLKDDEATHCRQCEKE 654
+EQ QE + +KL ++ + LK +DE H Q +++
Sbjct: 1826 LEEQLEQEAKERAAANKL----VRRTEKKLKEIFMQVEDERRHADQYKEQ 1871
Score = 75.5 bits (184), Expect = 2e-13
Identities = 83/383 (21%), Positives = 173/383 (45%), Gaps = 33/383 (8%)
Query: 268 LKGEDLDSQVGVIDFSLYLKDVQDLDGGKEHE------RITDVLDQKNYVEELNRHLSCT 321
L GE D Q + + + +++ KE E R D KN ++ R L
Sbjct: 1060 LDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQ 1119
Query: 322 VGDLQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQLRE----QNELIRERSEKSVEI 377
+ +LQ + + + +K +++ ++ + +L+ E + + Q EL +R ++ E+
Sbjct: 1120 IAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAEL 1179
Query: 378 TK---QDTKVELETYKQTRQGLDEMYSDVWKQLKEEKKVRLELEKELELQIGMKT---EM 431
K ++TK + RQ ++ +QL++ K+ + LEK + G++T E+
Sbjct: 1180 KKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQ---GLETDNKEL 1236
Query: 432 EIAMKLLEKDTHEKQDTLVALRQQLEEVKA-------INLQMFHKAQNAESSLQQKNEAI 484
+K+L++ E + L Q++E+ A + +++ KA ++ L + +
Sbjct: 1237 ACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLL 1296
Query: 485 TSFEGKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGGRIGALQLQLSQLHEQC 544
E K + +E +LQ ++ Q EE KL L RI L+ + + L EQ
Sbjct: 1297 EEAEKKGIKFAKDAASLESQLQDTQELLQ--EETRQKL--NLSSRIRQLEEEKNSLQEQQ 1352
Query: 545 SSLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKELRELQDEKAELQKICE 604
E+ K+ ++Q ALQ +L DT + +L +E L++ ++L + L + E
Sbjct: 1353 EEEEEARKNLEKQVLALQSQL---ADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLE 1409
Query: 605 EQEQALQEMGLHLSQSKLKMEDI 627
E+ A ++ ++ + +++D+
Sbjct: 1410 EKALAYDKLEKTKNRLQQELDDL 1432
Score = 73.2 bits (178), Expect = 8e-13
Identities = 72/335 (21%), Positives = 155/335 (46%), Gaps = 30/335 (8%)
Query: 338 KLQEELSAATDRICSLQEEQQQLREQNELIRERSEKSVEITKQDTKVELETYKQTRQGLD 397
K++E+ + + ++ + QQL E+ ++ E+ + E+ + ++ + +Q L+
Sbjct: 863 KVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAK-KQELE 921
Query: 398 EMYSDVWKQLKEE-----------KKVRL---ELEKELELQIGMKTEMEIAMKLLEKDTH 443
E+ D+ +++EE KK++ +LE++L+ + G + ++++ E
Sbjct: 922 EILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIK 981
Query: 444 EKQDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEE 503
+ ++ ++ L Q + M + S L ++ E + N+ + +EE
Sbjct: 982 KMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEE 1041
Query: 504 RLQHSERARQGAEERSHKLQQELGGRIGALQLQLSQLHEQCSSLEKEL-KSEKEQRQALQ 562
RL+ E+ RQ E K +++L G LQ Q+++L Q L+ +L K E+E + AL
Sbjct: 1042 RLKKEEKTRQELE----KAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALA 1097
Query: 563 R---ELQHEKDTSSLLRMELQQVEGLKKELRELQDEKAELQKICEEQEQALQEMGLHLSQ 619
R E H+ + ++R Q+ L++ + + EKA K E+Q++ L E L
Sbjct: 1098 RGDDETLHKNNALKVVRELQAQIAELQE---DFESEKASRNK-AEKQKRDLSE---ELEA 1150
Query: 620 SKLKMEDIKEVNQALKGHAWLKDDEATHCRQCEKE 654
K ++ED + A + ++ E ++ +E
Sbjct: 1151 LKTELEDTLDTTAAQQELRTKREQEVAELKKALEE 1185
Score = 57.0 bits (136), Expect = 6e-08
Identities = 105/498 (21%), Positives = 203/498 (40%), Gaps = 51/498 (10%)
Query: 152 MEHCLKHGLKVKKSFIGQNKSFFGPLELVEKLCPEASDIATSVRNLPELKTAVGRGRAWL 211
+ L+ L+ K+ F QNK +E L D+ +V L + K A+ + +
Sbjct: 1488 LARALEEALEAKEEFERQNKQLRADME---DLMSSKDDVGKNVHELEKSKRALEQQVEEM 1544
Query: 212 YLALMQKKLADYLKVLID-------NKHLLSEFYEPEALMMEEEGMVIVGLLVGLNVLDA 264
L ++L D L+ D N + +E + +E+ LL+ V +
Sbjct: 1545 RTQL--EELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIK-QVREL 1601
Query: 265 NLCLKGEDLDSQVGVIDFSLYLKDVQDLDGGKE--HERITDVLDQKNYVEELNRHLSCTV 322
L+ E + V D++DL+ E ++ +V+ Q ++ + +
Sbjct: 1602 EAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQREL 1661
Query: 323 GDLQTKIDGLEKTNSKLQEELSAATDRICSLQEE-QQQLREQNELIRERSEKSVEITKQD 381
+ + D + + + +++L + I LQEE R + +ER E + EIT
Sbjct: 1662 EEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSA 1721
Query: 382 TKVELETYKQTRQGLDEMYSDVWKQLKEEKKVRLELEKELELQIGMKTEMEIAMKLLEKD 441
+ ++ R L+ + + ++L+EE+ +EL + + ++ + A E+
Sbjct: 1722 SGKSALLDEKRR--LEARIAQLEEELEEEQS-NMELLNDRFRKTTLQVDTLNAELAAERS 1778
Query: 442 THEKQDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQKNEA-ITSFEGKTNQVMSSMKQ 500
+K D RQQLE N ++ K Q E +++ K +A I++ E K Q+ ++Q
Sbjct: 1779 AAQKSDNA---RQQLERQ---NKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQ 1832
Query: 501 -MEERLQHSERAR-----------QGAEERSHKLQQELGGRIGALQLQLSQLHEQCSSLE 548
+ER ++ R Q +ER H Q + ++ ++ QL Q E
Sbjct: 1833 EAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYK--EQMEKANARMKQLKRQLEEAE 1890
Query: 549 KELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKELRELQDEKAELQKICEEQEQ 608
+E R+ LQREL + + EGL +E+ L++ I +
Sbjct: 1891 EEATRANASRRKLQRELDDATEAN----------EGLSREVSTLKNRLRRGGPISFSSSR 1940
Query: 609 ALQEMGLHLSQSKLKMED 626
+ + LHL + L++ D
Sbjct: 1941 SGRRQ-LHLEGASLELSD 1957
Score = 50.1 bits (118), Expect = 7e-06
Identities = 51/226 (22%), Positives = 100/226 (44%), Gaps = 19/226 (8%)
Query: 404 WKQLKEEKKVRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAIN 463
W+ + K + +E ELQ + E +K+ EK T + +LEE++ +
Sbjct: 835 WRVFTKVKPLLQVTRQEEELQ----AKDEELLKVKEKQTK--------VEGELEEMERKH 882
Query: 464 LQMFHKAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQ 523
Q+ + LQ + E E ++ + +++EE L E + EER+ LQ
Sbjct: 883 QQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQ 942
Query: 524 QELGGRIGALQLQLSQLHEQCSSLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQVE 583
E +Q + L EQ E+E +K Q + + E + +K +L +E Q +
Sbjct: 943 NEK----KKMQAHIQDLEEQLD--EEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSK 996
Query: 584 GLKKELRELQDEKAELQKICEEQEQALQEMGLHLSQSKLKMEDIKE 629
+ KE + ++D AE E+E+ + + ++ ++ + D++E
Sbjct: 997 FI-KEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEE 1041
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 84.7 bits (208), Expect = 3e-16
Identities = 63/339 (18%), Positives = 170/339 (50%), Gaps = 14/339 (4%)
Query: 295 GKEHERITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICSLQ 354
G+ E+ V +Q+ V E + G ++ + + + +++E+ ++ ++
Sbjct: 101 GQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVR 160
Query: 355 EEQQQLREQNELIRERS----EKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLKEE 410
E++ Q+REQ +RE+ E+ ++ +Q+ ++ + + Q +E + +Q++++
Sbjct: 161 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQ--EEQMGEQEEQMQKQ 218
Query: 411 KKVRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKA 470
++ E E+++ Q E E ++ E+ ++++ + R+Q E+++ QM
Sbjct: 219 EEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQM---RKQEEQMREQEEQM---R 272
Query: 471 QNAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGGRI 530
+ E L+QK + T E +T + M++ EE+++ E + EE+ + ++++G +
Sbjct: 273 EQEEQMLKQKEQ--TEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQE 330
Query: 531 GALQLQLSQLHEQCSSLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKELR 590
+ Q Q+ EQ + K+ + EQ + +Q++ + + +R + +Q+ ++++R
Sbjct: 331 EQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMR 390
Query: 591 ELQDEKAELQKICEEQEQALQEMGLHLSQSKLKMEDIKE 629
+ +++ E ++ EQ++ ++E + + K +M +E
Sbjct: 391 KQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQEE 429
Score = 78.2 bits (191), Expect = 2e-14
Identities = 68/353 (19%), Positives = 169/353 (47%), Gaps = 17/353 (4%)
Query: 299 ERITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQ 358
E+ ++ ++ VE + + +L+ K LE L +E ++ ++E++
Sbjct: 11 EKNAELQEELQLVETEKSEIQLHIKELKRK---LETDKIPLPQE-GQVREQEGQVREQEG 66
Query: 359 QLREQNELIRERS----EKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLKEEKKVR 414
Q+REQ +RE+ E+ ++ +Q+ +V E Q R+ ++ + ++E +VR
Sbjct: 67 QVREQEGQVREQEGQVREQEGQVREQEGQVR-EQEGQVREQEGQVREQEGQVREQEGQVR 125
Query: 415 LELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQNAE 474
E E ++ Q G E E ++ E E++ + Q+ E + + + + E
Sbjct: 126 -EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQE 184
Query: 475 SSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGGRIGALQ 534
++++ + EG+ + M + EE++Q E EE+ K ++++G + +Q
Sbjct: 185 GQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQ 244
Query: 535 LQLSQLHEQCSSLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGL---KKELRE 591
Q Q+ +Q E++++ ++EQ + + +++ +++ + + +Q E ++++RE
Sbjct: 245 KQEEQVQKQ----EEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMRE 300
Query: 592 LQDEKAELQKICEEQEQALQEMGLHLSQSKLKMEDIKEVNQALKGHAWLKDDE 644
+++ E ++ EQE+ ++E + + + +M + KE K W ++++
Sbjct: 301 QEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQ 353
Score = 76.6 bits (187), Expect = 7e-14
Identities = 56/329 (17%), Positives = 160/329 (48%), Gaps = 10/329 (3%)
Query: 295 GKEHERITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICSLQ 354
G+ E+ V +Q+ V E + G ++ + + + +++E+ ++ ++
Sbjct: 115 GQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVR 174
Query: 355 EEQQQLREQNELIRERSEKSVEITKQ--DTKVELETYKQTRQGLDEMYSDVWKQLKEEKK 412
E++ Q+REQ +RE+ + E Q + + ++ ++ Q +E + +Q++++++
Sbjct: 175 EQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEE 234
Query: 413 VRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQN 472
E E++++ Q + E M+ E+ E+++ + R+Q E++ Q + Q
Sbjct: 235 QMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQM---REQEEQMLKQKEQTEQEEQT 291
Query: 473 AESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGGRIGA 532
E Q + + E + + M++ EE+++ E EE+ + ++++ +
Sbjct: 292 GEQEEQMREQ-----EEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQ 346
Query: 533 LQLQLSQLHEQCSSLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKELREL 592
+ Q Q+ EQ ++K+ + ++Q + ++++ + + +R + +Q+ K+++ E
Sbjct: 347 MWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQ 406
Query: 593 QDEKAELQKICEEQEQALQEMGLHLSQSK 621
+++ E ++ EQ++ +++ H+ + K
Sbjct: 407 KEQMREQEEQMGEQKEQMRKQEEHMGEQK 435
Score = 73.2 bits (178), Expect = 8e-13
Identities = 64/367 (17%), Positives = 173/367 (47%), Gaps = 9/367 (2%)
Query: 295 GKEHERITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICSLQ 354
G+ E+ V +Q+ V E + G ++ + + + +++E+ ++ ++
Sbjct: 52 GQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVR 111
Query: 355 EEQQQLREQNELIRERS----EKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLKEE 410
E++ Q+REQ +RE+ E+ ++ +Q+ +V E Q R+ ++ + ++E
Sbjct: 112 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVR-EQEGQVREQEGQVREQEGQVREQE 170
Query: 411 KKVRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKA 470
+VR E E ++ Q G E E M E E+++ + +Q+++ + + +
Sbjct: 171 GQVR-EQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQM 229
Query: 471 QNAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEER--SHKLQQELGG 528
+ E + ++ E + E + + M++ EE+++ E + EE+ K Q E
Sbjct: 230 RKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEE 289
Query: 529 RIGALQLQLSQLHEQCSSLEKELKSEKEQRQALQRELQHEKDTSSLLRMEL-QQVEGLKK 587
+ G + Q+ + EQ E++++ ++EQ + + ++ +++ + ++ +Q E + K
Sbjct: 290 QTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWK 349
Query: 588 ELRELQDEKAELQKICEEQEQALQEMGLHLSQSKLKMEDIKEVNQALKGHAWLKDDEATH 647
+ ++ +++ ++QK E+ + ++M Q + + E +++ + + ++
Sbjct: 350 QEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQ 409
Query: 648 CRQCEKE 654
R+ E++
Sbjct: 410 MREQEEQ 416
Score = 66.6 bits (161), Expect = 7e-11
Identities = 54/280 (19%), Positives = 129/280 (46%), Gaps = 15/280 (5%)
Query: 295 GKEHERITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICSLQ 354
G+ E+ V +Q+ V E + G ++ + + + ++ E+ ++ +Q
Sbjct: 157 GQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQ 216
Query: 355 EEQQQLREQNELIRERSEKSVEITKQDTKVELETYKQTRQ--GLDEMYSDVWKQLKEEKK 412
++++Q+ EQ E +R++ E+ E +Q K E + KQ Q +E + +Q++E+++
Sbjct: 217 KQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEE 276
Query: 413 VRL-------------ELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEV 459
L E E+++ Q E E M+ E+ E+++ + +Q+ E
Sbjct: 277 QMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQ 336
Query: 460 KAINLQMFHKAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEERS 519
K + + E + ++ E + E + + M++ EE+++ E + EE+
Sbjct: 337 KEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQM 396
Query: 520 HKLQQELGGRIGALQLQLSQLHEQCSSLEKELKSEKEQRQ 559
+ ++++G + ++ Q Q+ EQ + K+ + EQ++
Sbjct: 397 GEQKEQMGEQKEQMREQEEQMGEQKEQMRKQEEHMGEQKE 436
Score = 66.2 bits (160), Expect = 1e-10
Identities = 58/304 (19%), Positives = 141/304 (46%), Gaps = 8/304 (2%)
Query: 332 LEKTNSKLQEELSAATDRICSLQEEQQQLREQNELIRERSEKSVEITKQDTKVELETYKQ 391
L++ N++LQEEL +Q ++L+ + E + + ++ +Q+ +V E Q
Sbjct: 9 LKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVR-EQEGQ 67
Query: 392 TRQGLDEMYSDVWKQLKEEKKVR------LELEKELELQIGMKTEMEIAMKLLEKDTHEK 445
R+ ++ + ++E +VR E E ++ Q G E E ++ E E+
Sbjct: 68 VREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQ 127
Query: 446 QDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEERL 505
+ + Q+ E + + + + E ++++ + EG+ + +++ E ++
Sbjct: 128 EGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQV 187
Query: 506 QHSERARQGAEERSHKLQQELGGRIGALQLQLSQLHEQCSSLEKELKSEKEQRQALQREL 565
+ E E + + ++++G + +Q Q Q+ EQ + K+ + EQ + +Q++
Sbjct: 188 REQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQE 247
Query: 566 QHEKDTSSLLRMELQQVEGLKKELRELQDEKAELQKICEEQEQALQEMGLHLSQSKLKME 625
+ + +R + +Q+ ++++RE Q+E+ QK EQE+ E + + + +M
Sbjct: 248 EQVQKQEEQMRKQEEQMREQEEQMRE-QEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMR 306
Query: 626 DIKE 629
+ +E
Sbjct: 307 EQEE 310
Score = 48.9 bits (115), Expect = 2e-05
Identities = 40/222 (18%), Positives = 105/222 (47%), Gaps = 1/222 (0%)
Query: 408 KEEKKVRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMF 467
+E K+ EL++EL+L K+E+++ +K L++ + L Q E+ + Q
Sbjct: 7 EELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVREQE- 65
Query: 468 HKAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELG 527
+ + E ++++ + EG+ + +++ E +++ E + E + + + ++
Sbjct: 66 GQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVR 125
Query: 528 GRIGALQLQLSQLHEQCSSLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKK 587
+ G ++ Q Q+ EQ + ++ +EQ ++ + ++ +R + QV +
Sbjct: 126 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 185
Query: 588 ELRELQDEKAELQKICEEQEQALQEMGLHLSQSKLKMEDIKE 629
++RE + + E + EQE+ + E + + + +M + +E
Sbjct: 186 QVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEE 227
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 84.3 bits (207), Expect = 3e-16
Identities = 80/352 (22%), Positives = 165/352 (46%), Gaps = 33/352 (9%)
Query: 297 EHERITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICSLQEE 356
E E D+ ++ +E+ L + DL+ + EK + ++ T+ + +L E
Sbjct: 978 EEEVNADLAARRRKLEDECTELKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDES 1037
Query: 357 QQQLREQNELIRERSEKSV-EITKQDTKVELETYKQTRQGLDEMYSDVWKQLKEEKKVRL 415
+L ++ + ++E ++++ ++ ++ +V T + R L++ D+ L++EKK+R+
Sbjct: 1038 VARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLR--LEQQVEDLECSLEQEKKLRM 1095
Query: 416 ELEK-----ELELQIGMKTEMEIAM--KLLEKDTHEKQDTLVALRQQLEEVKAINLQMFH 468
+ E+ E +L++ ++ + A + LE+ +K L L ++E+ + + QM
Sbjct: 1096 DTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQK 1155
Query: 469 K-------AQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEERSHK 521
K A+ E L+ + A E + + ++++ ERL+ + A G E K
Sbjct: 1156 KIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRK 1215
Query: 522 LQQELGGRIGALQLQLSQLHEQCSSLEKELKSE-----KEQRQALQRELQHEKDTSSLLR 576
+ EL GR+ + + HE + + ++E EQ +LQR Q + S LR
Sbjct: 1216 REAEL-GRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELR 1274
Query: 577 MELQQVEGLKKELRELQDEKAELQKICEEQEQALQEMGLHLSQSKLKMEDIK 628
ME V+ L + L KA +K+C E LS++K+K+E+++
Sbjct: 1275 ME---VDDLAANVETLTRAKASAEKLCRTYED-------QLSEAKIKVEELQ 1316
Score = 62.4 bits (150), Expect = 1e-09
Identities = 79/344 (22%), Positives = 153/344 (44%), Gaps = 38/344 (11%)
Query: 329 IDGLEKTNSKLQEELSAATDRICSLQEEQQQLREQNELIR-ERSEKSVEITKQDTKVELE 387
++ L++ N LQEE+S TD++ + Q+L + + + E+SE + + + +ELE
Sbjct: 1544 LETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELE 1603
Query: 388 TYKQTRQGLD--EMYSDVWKQL--KEEKKVRLE---------LEKELELQIGMKTEMEIA 434
K R L+ ++ ++V ++L K+E+ L L+ L+ + + E
Sbjct: 1604 ETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRL 1663
Query: 435 MKLLEKDTHEKQDTLVALRQQLEEVKAIN--LQMFHKAQNAESSLQQK-----NEAITSF 487
K +E D ++ + L +Q E +A +Q K + A +Q+ +E +
Sbjct: 1664 KKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQAL 1723
Query: 488 EGKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGGRIGALQLQLSQLHEQCSSL 547
E + + + + ++++ L+ ER+R+ AE+ + + R+ L Q + L Q L
Sbjct: 1724 ERRASLLAAELEELRAALEQGERSRRLAEQELLEATE----RLNLLHSQNTGLLNQKKKL 1779
Query: 548 EKELKS-EKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKEL----------RELQDEK 596
E +L E +A Q + E+ + E LKKE + L+
Sbjct: 1780 EADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTV 1839
Query: 597 AELQKICEEQEQALQEMG-LHLSQSKLKMEDIK-EVNQALKGHA 638
ELQ EE EQA G + + + K+ +++ E++ K HA
Sbjct: 1840 RELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHA 1883
Score = 60.5 bits (145), Expect = 5e-09
Identities = 69/352 (19%), Positives = 147/352 (41%), Gaps = 11/352 (3%)
Query: 313 ELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRIC-SLQEEQQQLREQNELIR--E 369
EL R LS ++ E + EEL A ++ LQE ++ + N E
Sbjct: 1405 ELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLE 1464
Query: 370 RSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLKEEKKVRLELEKELELQIGMKT 429
+++ ++ +D +ELE LD+ + + L+E ++ E+++ELE
Sbjct: 1465 KAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESR 1524
Query: 430 EMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQKNEAITSFEG 489
+ + L E + L L+++ + ++ + + + S+Q+ + + EG
Sbjct: 1525 GLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEG 1584
Query: 490 KTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGGRIGALQLQLSQLHEQCSSLEK 549
+ +++ ++ L+ +E A + E ++ ++Q EL + +L++ E+C++L +
Sbjct: 1585 EKSEIQAA-------LEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRR 1637
Query: 550 ELKSEKEQRQA-LQRELQHEKDTSSLLRMELQQVEGLKKELRELQDEKAELQKICEEQEQ 608
+ E QA L E + + L + + L+ +L + E Q +
Sbjct: 1638 NHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQA 1697
Query: 609 ALQEMGLHLSQSKLKMEDIKEVNQALKGHAWLKDDEATHCRQCEKEFSISRR 660
L+E + + ++ E QAL+ A L E R ++ SRR
Sbjct: 1698 QLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRR 1749
Score = 56.6 bits (135), Expect = 8e-08
Identities = 81/381 (21%), Positives = 163/381 (42%), Gaps = 69/381 (18%)
Query: 297 EHERITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICSLQEE 356
E +R++ + K +E+ L C++ + E+ KL+ +L + + ++
Sbjct: 1062 EEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQD 1121
Query: 357 QQQLREQ-----NELIR---------------ERSEKSVEITKQDTKVELETYKQTRQGL 396
+QQL E+ +EL + ++ K ++ ++ + ELE + R +
Sbjct: 1122 KQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARV 1181
Query: 397 DEMYSDVWKQLKEEKKVRLE----------------------LEKELELQIGMKTEMEIA 434
++ ++ ++L EE RLE L +ELE + ++ E +A
Sbjct: 1182 EKQRAEAAREL-EELSERLEEAGGASAGQREGCRKREAELGRLRRELE-EAALRHEATVA 1239
Query: 435 MKLLEK-----DTHEKQDTLVALRQQLEEVKA-INLQMFHKAQNAESSLQQKNEAITSFE 488
++ + E+ D+L +RQ+LE+ K+ + +++ A N E+ + K A
Sbjct: 1240 ALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCR 1299
Query: 489 GKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGGRIGALQLQLSQLHEQCSSLE 548
+Q+ + ++EE +R A + +LQ E G +LS+L E+ L
Sbjct: 1300 TYEDQLSEAKIKVEEL----QRQLADASTQRGRLQTESG--------ELSRLLEEKECLI 1347
Query: 549 KELKSEK----EQRQALQRELQHEKDTSSLLRMELQQVEGLKKELRELQDEKAELQKICE 604
+L K + + L+R+L+ E S L +Q + LRE +E+AE Q
Sbjct: 1348 SQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQ---A 1404
Query: 605 EQEQALQEMGLHLSQSKLKME 625
E ++ L + ++Q + K E
Sbjct: 1405 ELQRLLSKANAEVAQWRSKYE 1425
Score = 56.2 bits (134), Expect = 1e-07
Identities = 70/353 (19%), Positives = 162/353 (45%), Gaps = 45/353 (12%)
Query: 333 EKTNSKLQEELSAATDRICSLQEEQQQLREQN-ELIRERSEKSVEI-TKQDTKVELET-- 388
E+ + L+ EL + + + ++Q+L E + + +E+++ ++++ +QD + E
Sbjct: 895 EEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLADAEERC 954
Query: 389 --YKQTRQGLDEMYSDVWKQLKEEKKVRLEL---EKELELQIG-MKTEMEIAMKLLEKDT 442
+++ L+ ++ ++L++E++V +L ++LE + +K +++ L K
Sbjct: 955 HLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTLAKAE 1014
Query: 443 HEKQDTLVALRQQLEEVKAIN------------LQMFHKAQNAESSLQQKNEAITSFEGK 490
EKQ T ++ EE+ A++ LQ H Q A LQ + + +++
Sbjct: 1015 KEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAH--QQALGDLQAEEDRVSALTKA 1072
Query: 491 TNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGGRIGALQLQLSQLHEQCSSLEKE 550
++ ++ +E L+ ++ R E KL+ G + Q ++ + LE++
Sbjct: 1073 KLRLEQQVEDLECSLEQEKKLRMDTERAKRKLE----GDLKLTQESVADAAQDKQQLEEK 1128
Query: 551 LKSEKEQRQALQRELQHEKDTSSLLRMELQQVEG--LKKELRELQDEKAELQKICEEQEQ 608
LK + + L LR+E +Q+ G ++K+++ELQ EL++ E +
Sbjct: 1129 LKKKDSELSQLS------------LRVEDEQLLGAQMQKKIKELQARAEELEEELEAERA 1176
Query: 609 ALQEMGLHLSQSKLKMEDIKEVNQALKGHAWLKDDEATHCRQCEKEFSISRRK 661
A + +++ ++E E+++ L+ + CR+ E E RR+
Sbjct: 1177 ARARVEKQRAEAARELE---ELSERLEEAGGASAGQREGCRKREAELGRLRRE 1226
Score = 45.8 bits (107), Expect = 1e-04
Identities = 60/282 (21%), Positives = 121/282 (42%), Gaps = 38/282 (13%)
Query: 294 GGKEHERITDVL-DQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICS 352
G E +R+ L +Q +E L+ + +L+ ++ E++ ++EL AT+R+
Sbjct: 1705 GRDEEQRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNL 1764
Query: 353 LQEEQQQLREQNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLKEEKK 412
L + L Q +K +E E+E Q R+ +E K + +
Sbjct: 1765 LHSQNTGLLNQ--------KKKLEADLAQLSGEVEEAAQERREAEEKAK---KAITDAAM 1813
Query: 413 VRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHK-AQ 471
+ EL+KE + +E K LE+ E L+ +LEE + L+ K Q
Sbjct: 1814 MAEELKKEQD----TSAHLERMKKTLEQTVRE-------LQARLEEAEQAALRGGKKQVQ 1862
Query: 472 NAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGGRIG 531
E+ +++ + + + K + + +++ E R++ E A Q E+R + +
Sbjct: 1863 KLEAKVRELEAELDAEQKKHAEALKGVRKHERRVK--ELAYQAEEDRKN---------LA 1911
Query: 532 ALQLQLSQLHEQCSSLEKELKSEKEQRQ---ALQRELQHEKD 570
+Q + +L + S +++ + ++Q A R+ QHE D
Sbjct: 1912 RMQDLVDKLQSKVKSYKRQFEEAEQQANTNLAKYRKAQHELD 1953
Score = 37.4 bits (85), Expect = 0.048
Identities = 36/121 (29%), Positives = 58/121 (47%), Gaps = 14/121 (11%)
Query: 515 AEERSHKLQQELGGRIGAL---QLQLSQLHEQCSSLEKELKSEKEQRQALQRELQHEKDT 571
AEE L+ EL G GAL + + +L E S+ +E Q QA Q L ++
Sbjct: 894 AEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLADAEER 953
Query: 572 SSLLRMELQQVEGLKKELRE-LQDE----------KAELQKICEEQEQALQEMGLHLSQS 620
LL Q+EG KEL E L+DE + +L+ C E ++ + ++ L L+++
Sbjct: 954 CHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTLAKA 1013
Query: 621 K 621
+
Sbjct: 1014 E 1014
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.130 0.361
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,707,247
Number of Sequences: 37866
Number of extensions: 1328263
Number of successful extensions: 20133
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 521
Number of HSP's successfully gapped in prelim test: 1089
Number of HSP's that attempted gapping in prelim test: 7720
Number of HSP's gapped (non-prelim): 5965
length of query: 708
length of database: 18,247,518
effective HSP length: 109
effective length of query: 599
effective length of database: 14,120,124
effective search space: 8457954276
effective search space used: 8457954276
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.