Search of human proteins with 94721268

Search of human proteins with 94721268

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|94721268 villin-like protein [Homo sapiens]
         (856 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|94721268 villin-like protein [Homo sapiens]                       1744   0.0  
gi|194394237 villin 1 [Homo sapiens]                                  789   0.0  
gi|17572824 advillin [Homo sapiens]                                   756   0.0  
gi|162951877 scinderin isoform 1 [Homo sapiens]                       505   e-143
gi|4504165 gelsolin isoform a precursor [Homo sapiens]                503   e-142
gi|38044288 gelsolin isoform b [Homo sapiens]                         503   e-142
gi|189083782 gelsolin isoform c [Homo sapiens]                        503   e-142
gi|189083780 gelsolin isoform c [Homo sapiens]                        503   e-142
gi|189083778 gelsolin isoform b [Homo sapiens]                        503   e-142
gi|189083776 gelsolin isoform b [Homo sapiens]                        503   e-142
gi|189083774 gelsolin isoform b [Homo sapiens]                        503   e-142
gi|189083772 gelsolin isoform b [Homo sapiens]                        503   e-142
gi|14916473 scinderin isoform 2 [Homo sapiens]                        340   3e-93
gi|63252913 gelsolin-like capping protein [Homo sapiens]              211   3e-54
gi|4503743 flightless I homolog [Homo sapiens]                        181   2e-45
gi|150417973 supervillin isoform 2 [Homo sapiens]                     162   1e-39
gi|150417971 supervillin isoform 1 [Homo sapiens]                     162   1e-39
gi|166706877 erythrocyte membrane protein band 4.9 isoform 1 [Ho...    45   4e-04
gi|166706885 erythrocyte membrane protein band 4.9 isoform 3 [Ho...    45   4e-04
gi|166706883 erythrocyte membrane protein band 4.9 isoform 2 [Ho...    45   4e-04
gi|166706881 erythrocyte membrane protein band 4.9 isoform 2 [Ho...    45   4e-04
gi|166706879 erythrocyte membrane protein band 4.9 isoform 1 [Ho...    45   4e-04
gi|166706875 erythrocyte membrane protein band 4.9 isoform 1 [Ho...    45   4e-04
gi|153792514 actin binding LIM protein family, member 2 isoform ...    44   5e-04
gi|194272204 actin binding LIM protein family, member 2 isoform ...    44   5e-04
gi|194272202 actin binding LIM protein family, member 2 isoform ...    44   5e-04
gi|194272200 actin binding LIM protein family, member 2 isoform ...    44   5e-04
gi|194272198 actin binding LIM protein family, member 2 isoform ...    44   5e-04
gi|194272196 actin binding LIM protein family, member 2 isoform ...    44   5e-04
gi|7662330 actin binding LIM protein family, member 3 [Homo sapi...    42   0.003

>gi|94721268 villin-like protein [Homo sapiens]
          Length = 856

 Score = 1744 bits (4518), Expect = 0.0
 Identities = 856/856 (100%), Positives = 856/856 (100%)

Query: 1   MDISKGLPGMQGGLHIWISENRKMVPVPEGAYGNFFEEHCYVILHVPQSPKATQGASSDL 60
           MDISKGLPGMQGGLHIWISENRKMVPVPEGAYGNFFEEHCYVILHVPQSPKATQGASSDL
Sbjct: 1   MDISKGLPGMQGGLHIWISENRKMVPVPEGAYGNFFEEHCYVILHVPQSPKATQGASSDL 60

Query: 61  HYWVGKQAGAEAQGAAEAFQQRLQDELGGQTVLHREAQGHESDCFCSYFRPGIIYRKGGL 120
           HYWVGKQAGAEAQGAAEAFQQRLQDELGGQTVLHREAQGHESDCFCSYFRPGIIYRKGGL
Sbjct: 61  HYWVGKQAGAEAQGAAEAFQQRLQDELGGQTVLHREAQGHESDCFCSYFRPGIIYRKGGL 120

Query: 121 ASDLKHVETNLFNIQRLLHIKGRKHVSATEVELSWNSFNKGDIFLLDLGKMMIQWNGPKT 180
           ASDLKHVETNLFNIQRLLHIKGRKHVSATEVELSWNSFNKGDIFLLDLGKMMIQWNGPKT
Sbjct: 121 ASDLKHVETNLFNIQRLLHIKGRKHVSATEVELSWNSFNKGDIFLLDLGKMMIQWNGPKT 180

Query: 181 SISEKARGLALTYSLRDRERGGGRAQIGVVDDEAKAPDLMQIMEAVLGRRVGSLRAATPS 240
           SISEKARGLALTYSLRDRERGGGRAQIGVVDDEAKAPDLMQIMEAVLGRRVGSLRAATPS
Sbjct: 181 SISEKARGLALTYSLRDRERGGGRAQIGVVDDEAKAPDLMQIMEAVLGRRVGSLRAATPS 240

Query: 241 KDINQLQKANVRLYHVYEKGKDLVVLELATPPLTQDLLQEEDFYILDQGGFKIYVWQGRM 300
           KDINQLQKANVRLYHVYEKGKDLVVLELATPPLTQDLLQEEDFYILDQGGFKIYVWQGRM
Sbjct: 241 KDINQLQKANVRLYHVYEKGKDLVVLELATPPLTQDLLQEEDFYILDQGGFKIYVWQGRM 300

Query: 301 SSLQERKAAFSRAVGFIQAKGYPTYTNVEVVNDGAESAAFKQLFRTWSEKRRRNQKLGGR 360
           SSLQERKAAFSRAVGFIQAKGYPTYTNVEVVNDGAESAAFKQLFRTWSEKRRRNQKLGGR
Sbjct: 301 SSLQERKAAFSRAVGFIQAKGYPTYTNVEVVNDGAESAAFKQLFRTWSEKRRRNQKLGGR 360

Query: 361 DKSIHVKLDVGKLHTQPKLAAQLRMVDDGSGKVEVWCIQDLHRQPVDPKRHGQLCAGNCY 420
           DKSIHVKLDVGKLHTQPKLAAQLRMVDDGSGKVEVWCIQDLHRQPVDPKRHGQLCAGNCY
Sbjct: 361 DKSIHVKLDVGKLHTQPKLAAQLRMVDDGSGKVEVWCIQDLHRQPVDPKRHGQLCAGNCY 420

Query: 421 LVLYTYQRLGRVQYILYLWQGHQATADEIEALNSNAEELDVMYGGVLVQEHVTMGSEPPH 480
           LVLYTYQRLGRVQYILYLWQGHQATADEIEALNSNAEELDVMYGGVLVQEHVTMGSEPPH
Sbjct: 421 LVLYTYQRLGRVQYILYLWQGHQATADEIEALNSNAEELDVMYGGVLVQEHVTMGSEPPH 480

Query: 481 FLAIFQGQLVIFQERAGHHGKGQSASTTRLFQVQGTDSHNTRTMEVPARASSLNSSDIFL 540
           FLAIFQGQLVIFQERAGHHGKGQSASTTRLFQVQGTDSHNTRTMEVPARASSLNSSDIFL
Sbjct: 481 FLAIFQGQLVIFQERAGHHGKGQSASTTRLFQVQGTDSHNTRTMEVPARASSLNSSDIFL 540

Query: 541 LVTASVCYLWFGKGCNGDQREMARVVVTVISRKNEETVLEGQEPPHFWEALGGRAPYPSN 600
           LVTASVCYLWFGKGCNGDQREMARVVVTVISRKNEETVLEGQEPPHFWEALGGRAPYPSN
Sbjct: 541 LVTASVCYLWFGKGCNGDQREMARVVVTVISRKNEETVLEGQEPPHFWEALGGRAPYPSN 600

Query: 601 KRLPEEVPSFQPRLFECSSHMGCLVLAEVGFFSQEDLDKYDIMLLDTWQEIFLWLGEAAS 660
           KRLPEEVPSFQPRLFECSSHMGCLVLAEVGFFSQEDLDKYDIMLLDTWQEIFLWLGEAAS
Sbjct: 601 KRLPEEVPSFQPRLFECSSHMGCLVLAEVGFFSQEDLDKYDIMLLDTWQEIFLWLGEAAS 660

Query: 661 EWKEAVAWGQEYLKTHPAGRSPATPIVLVKQGHEPPTFIGWFFTWDPYKWTSHPSHKEVV 720
           EWKEAVAWGQEYLKTHPAGRSPATPIVLVKQGHEPPTFIGWFFTWDPYKWTSHPSHKEVV
Sbjct: 661 EWKEAVAWGQEYLKTHPAGRSPATPIVLVKQGHEPPTFIGWFFTWDPYKWTSHPSHKEVV 720

Query: 721 DGSPAAASTISEITAEVNNLRLSRWPGNGRAGAVALQALKGSQDSSENDLVRSPKSAGSR 780
           DGSPAAASTISEITAEVNNLRLSRWPGNGRAGAVALQALKGSQDSSENDLVRSPKSAGSR
Sbjct: 721 DGSPAAASTISEITAEVNNLRLSRWPGNGRAGAVALQALKGSQDSSENDLVRSPKSAGSR 780

Query: 781 TSSSVSSTSATINGGLRREQLMHQAVEDLPEGVDPARREFYLSDSDFQDIFGKSKEEFYS 840
           TSSSVSSTSATINGGLRREQLMHQAVEDLPEGVDPARREFYLSDSDFQDIFGKSKEEFYS
Sbjct: 781 TSSSVSSTSATINGGLRREQLMHQAVEDLPEGVDPARREFYLSDSDFQDIFGKSKEEFYS 840

Query: 841 MATWRQRQEKKQLGFF 856
           MATWRQRQEKKQLGFF
Sbjct: 841 MATWRQRQEKKQLGFF 856


>gi|194394237 villin 1 [Homo sapiens]
          Length = 827

 Score =  789 bits (2037), Expect = 0.0
 Identities = 408/853 (47%), Positives = 558/853 (65%), Gaps = 52/853 (6%)

Query: 13  GLHIWISENRKMVPVPEGAYGNFFEEHCYVILHVPQSPKATQGASSDLHYWVGKQAGAEA 72
           GL IW  E  +MVPVP   +G+FF+  CY+IL +    K     S D+HYW+G+ +  + 
Sbjct: 18  GLQIWRIEAMQMVPVPSSTFGSFFDGDCYIILAIH---KTASSLSYDIHYWIGQDSSLDE 74

Query: 73  QGAAEAFQQRLQDELGGQTVLHREAQGHESDCFCSYFRPGIIYRKGGLASDLKHVETNLF 132
           QGAA  +  ++ D L G+ V HRE QG+ES+ F  YF+ G++ RKGG+AS +KHVETN +
Sbjct: 75  QGAAAIYTTQMDDFLKGRAVQHREVQGNESEAFRGYFKQGLVIRKGGVASGMKHVETNSY 134

Query: 133 NIQRLLHIKGRKHVSATEVELSWNSFNKGDIFLLDLGKMMIQWNGPKTSISEKARGLALT 192
           ++QRLLH+KG+++V A EVE+SW SFN+GD+FLLDLGK++IQWNGP+++  E+ RG+ L 
Sbjct: 135 DVQRLLHVKGKRNVVAGEVEMSWKSFNRGDVFLLDLGKLIIQWNGPESTRMERLRGMTLA 194

Query: 193 YSLRDRERGGGRAQIGVVD--DEAKAPDLMQIMEAVLGRRVGSLRAATPSKDINQLQKAN 250
             +RD+ERGG R  +GVVD  +E  +P LM++M  VLG+R   L+AA P   +    KA 
Sbjct: 195 KEIRDQERGG-RTYVGVVDGENELASPKLMEVMNHVLGKR-RELKAAVPDTVVEPALKAA 252

Query: 251 VRLYHVYEKGKDLVVLELATPPLTQDLLQEEDFYILDQGGFKIYVWQGRMSSLQERKAAF 310
           ++LYHV +   +LVV E+AT PLTQDLL  ED YILDQGG KIYVW+G+ ++ QE+K A 
Sbjct: 253 LKLYHVSDSEGNLVVREVATRPLTQDLLSHEDCYILDQGGLKIYVWKGKKANEQEKKGAM 312

Query: 311 SRAVGFIQAKGYPTYTNVEVVNDGAESAAFKQLFRTWSEKRR-----RNQKLGGRDKSIH 365
           S A+ FI+AK YP  T VEV NDGAESA F+QLF+ W+   R     +   +G   K   
Sbjct: 313 SHALNFIKAKQYPPSTQVEVQNDGAESAVFQQLFQKWTASNRTSGLGKTHTVGSVAKVEQ 372

Query: 366 VKLDVGKLHTQPKLAAQLRMVDDGSGKVEVWCIQDLHRQPVDPKRHGQLCAGNCYLVLYT 425
           VK D   +H +P++AAQ +MVDDGSG+V+VW I++L   PVD K  G    G+CYL+LYT
Sbjct: 373 VKFDATSMHVKPQVAAQQKMVDDGSGEVQVWRIENLELVPVDSKWLGHFYGGDCYLLLYT 432

Query: 426 YQRLGRVQYILYLWQGHQATADEIEALNSNAEELDVMYGGVLVQEHVTMGSEPPHFLAIF 485
           Y    +  Y+LY+WQG QA+ DEI A    A  LD  Y G  VQ  V MG EPPH ++IF
Sbjct: 433 YLIGEKQHYLLYVWQGSQASQDEITASAYQAVILDQKYNGEPVQIRVPMGKEPPHLMSIF 492

Query: 486 QGQLVIFQERAGHHGKGQSASTTRLFQVQGTDSHNTRTMEVPARASSLNSSDIFLLVTAS 545
           +G++V++Q         ++  +TRLFQVQGT ++NT+  EVPARA+ LNS+D+F+L T S
Sbjct: 493 KGRMVVYQGGTSRTNNLETGPSTRLFQVQGTGANNTKAFEVPARANFLNSNDVFVLKTQS 552

Query: 546 VCYLWFGKGCNGDQREMARVVVTVISRKNEETVLEGQEPPHFWEALGGRAPYPSNKRLPE 605
            CYLW GKGC+GD+REMA++V   ISR  ++ V+EGQEP +FW ALGG+APY + KRL E
Sbjct: 553 CCYLWCGKGCSGDEREMAKMVADTISRTEKQVVVEGQEPANFWMALGGKAPYANTKRLQE 612

Query: 606 EVPSFQPRLFECSSHMGCLVLAEVGFFSQEDLDKYDIMLLDTWQEIFLWLGEAASEW--K 663
           E     PRLFECS+  G  +  E+  F+Q+DL++ D+ LLD W ++F W+G+ A+E   K
Sbjct: 613 ENLVITPRLFECSNKTGRFLATEIPDFNQDDLEEDDVFLLDVWDQVFFWIGKHANEEEKK 672

Query: 664 EAVAWGQEYLKTHPAGRSPATPIVLVKQGHEPPTFIGWFFTWDPYKWTSHPSHKEVVDGS 723
            A    QEYLKTHP+GR P TPI++VKQGHEPPTF GWF  WDP+KW++  S+++     
Sbjct: 673 AAATTAQEYLKTHPSGRDPETPIIVVKQGHEPPTFTGWFLAWDPFKWSNTKSYED----- 727

Query: 724 PAAASTISEITAEVNNLRLSRWPGNGRAGAVALQALKGSQDSSENDLVRSPKSAGSRTSS 783
                    + AE+ N R   W                SQ ++E   V SPK      +S
Sbjct: 728 ---------LKAELGNSR--DW----------------SQITAE---VTSPKVDVFNANS 757

Query: 784 SVSSTSATINGGLRREQLMHQAVEDLPEGVDPARREFYLSDSDFQDIFGKSKEEFYSMAT 843
           ++SS    I      EQL+++ VE+LPEGVDP+R+E +LS  DF   FG +   F ++  
Sbjct: 758 NLSSGPLPI---FPLEQLVNKPVEELPEGVDPSRKEEHLSIEDFTQAFGMTPAAFSALPR 814

Query: 844 WRQRQEKKQLGFF 856
           W+Q+  KK+ G F
Sbjct: 815 WKQQNLKKEKGLF 827



 Score = 88.2 bits (217), Expect = 3e-17
 Identities = 106/426 (24%), Positives = 177/426 (41%), Gaps = 65/426 (15%)

Query: 12  GGLHIWISENRKMVPVPEGAYGNFFEEHCYVILHVPQSPKATQGASSDLHY----WVGKQ 67
           G + +W  EN ++VPV     G+F+   CY++L+       T       HY    W G Q
Sbjct: 398 GEVQVWRIENLELVPVDSKWLGHFYGGDCYLLLY-------TYLIGEKQHYLLYVWQGSQ 450

Query: 68  AGAEAQGAAEAFQQRLQDE-LGGQTVLHREAQGHESDCFCSYFRPGIIYRKGGLASDLKH 126
           A ++ +  A A+Q  + D+   G+ V  R   G E     S F+  ++  +GG  S   +
Sbjct: 451 A-SQDEITASAYQAVILDQKYNGEPVQIRVPMGKEPPHLMSIFKGRMVVYQGG-TSRTNN 508

Query: 127 VE----TNLFNIQRLLHIKGRKHVSATEVELSWNSFNKGDIFLLDLGKMMIQWNGPKTSI 182
           +E    T LF +Q      G  +  A EV    N  N  D+F+L        W G   S 
Sbjct: 509 LETGPSTRLFQVQG----TGANNTKAFEVPARANFLNSNDVFVLKTQSCCYLWCGKGCSG 564

Query: 183 SEK--ARGLALTYSLRDRERGGGRAQIGVVDDEAKAPDLMQIMEAVLGRRVGSLRAATPS 240
            E+  A+ +A T S  +++         VV+ +  A   M            +L    P 
Sbjct: 565 DEREMAKMVADTISRTEKQ--------VVVEGQEPANFWM------------ALGGKAPY 604

Query: 241 KDINQLQKANV----RLYHVYEKGKDLVVLELATPPLTQDLLQEEDFYILDQGGFKIYVW 296
            +  +LQ+ N+    RL+    K    +  E+  P   QD L+E+D ++LD    +++ W
Sbjct: 605 ANTKRLQEENLVITPRLFECSNKTGRFLATEI--PDFNQDDLEEDDVFLLDVWD-QVFFW 661

Query: 297 QGRMSSLQERKAAFSRAVGFIQA--KGYPTYTNVEVVNDGAESAAFKQLFRTWSEKRRRN 354
            G+ ++ +E+KAA + A  +++    G    T + VV  G E   F   F  W   +  N
Sbjct: 662 IGKHANEEEKKAAATTAQEYLKTHPSGRDPETPIIVVKQGHEPPTFTGWFLAWDPFKWSN 721

Query: 355 QK--------LGGRDKSIHVKLDVGKLHTQPKLAAQLRMVDDGSGKVEVWCIQDLHRQPV 406
            K        LG       +  +V    T PK+       +  SG + ++ ++ L  +PV
Sbjct: 722 TKSYEDLKAELGNSRDWSQITAEV----TSPKVDVFNANSNLSSGPLPIFPLEQLVNKPV 777

Query: 407 DPKRHG 412
           +    G
Sbjct: 778 EELPEG 783


>gi|17572824 advillin [Homo sapiens]
          Length = 819

 Score =  756 bits (1952), Expect = 0.0
 Identities = 385/853 (45%), Positives = 554/853 (64%), Gaps = 57/853 (6%)

Query: 13  GLHIWISENRKMVPVPEGAYGNFFEEHCYVILHVPQSPKATQGASSDLHYWVGKQAGAEA 72
           G+ +W  E  ++  VP  A+GNF+E  CYVIL    + +     S D+H+W+GK +  + 
Sbjct: 15  GIIVWRIEKMELALVPVSAHGNFYEGDCYVIL---STRRVASLLSQDIHFWIGKDSSQDE 71

Query: 73  QGAAEAFQQRLQDELGGQTVLHREAQGHESDCFCSYFRPGIIYRKGGLASDLKHVETNLF 132
           Q  A  +  +L D LGG  V HRE Q HESD F  YF+ GIIY++GG+AS +KHVETN +
Sbjct: 72  QSCAAIYTTQLDDYLGGSPVQHREVQYHESDTFRGYFKQGIIYKQGGVASGMKHVETNTY 131

Query: 133 NIQRLLHIKGRKHVSATEVELSWNSFNKGDIFLLDLGKMMIQWNGPKTSISEKARGLALT 192
           +++RLLH+KG++++ ATEVE+SW+SFN+GD+FLLDLGK++IQWNGP+++  E+ + + L 
Sbjct: 132 DVKRLLHVKGKRNIRATEVEMSWDSFNRGDVFLLDLGKVIIQWNGPESNSGERLKAMLLA 191

Query: 193 YSLRDRERGGGRAQIGVV--DDEAKAPDLMQIMEAVLGRRVGSLRAATPSKDINQLQKAN 250
             +RDRERGG RA+IGV+  D EA +P+LM++++  LGRR   ++   P + I+Q QK+ 
Sbjct: 192 KDIRDRERGG-RAEIGVIEGDKEAASPELMKVLQDTLGRR-SIIKPTVPDEIIDQKQKST 249

Query: 251 VRLYHVYEKGKDLVVLELATPPLTQDLLQEEDFYILDQGGFKIYVWQGRMSSLQERKAAF 310
           + LYH+ +    L V E+AT PL QDLL  +D YILDQ G KIYVW+G+ ++  E++AA 
Sbjct: 250 IMLYHISDSAGQLAVTEVATRPLVQDLLNHDDCYILDQSGTKIYVWKGKGATKAEKQAAM 309

Query: 311 SRAVGFIQAKGYPTYTNVEVVNDGAESAAFKQLFRTWSEKRR-----RNQKLGGRDKSIH 365
           S+A+GFI+ K YP+ TNVE VNDGAESA FKQLF+ WS K +     +   +G   K   
Sbjct: 310 SKALGFIKMKSYPSSTNVETVNDGAESAMFKQLFQKWSVKDQTMGLGKTFSIGKIAKVFQ 369

Query: 366 VKLDVGKLHTQPKLAAQLRMVDDGSGKVEVWCIQDLHRQPVDPKRHGQLCAGNCYLVLYT 425
            K DV  LHT+P++AAQ RMVDDG+GKVEVW I++L   PV+ + +G    G+CYLVLYT
Sbjct: 370 DKFDVTLLHTKPEVAAQERMVDDGNGKVEVWRIENLELVPVEYQWYGFFYGGDCYLVLYT 429

Query: 426 YQRLGRVQYILYLWQGHQATADEIEALNSNAEELDVMYGGVLVQEHVTMGSEPPHFLAIF 485
           Y+  G+  +ILY+WQG  A+ DE+ A    A E+D  + G  VQ  V MG+EP HF+AIF
Sbjct: 430 YEVNGKPHHILYIWQGRHASQDELAASAYQAVEVDRQFDGAAVQVRVRMGTEPRHFMAIF 489

Query: 486 QGQLVIFQERAGHHGKGQSASTTRLFQVQGTDSHNTRTMEVPARASSLNSSDIFLLVTAS 545
           +G+LVIF+      G  +     RLFQ+ G D  NT+ +EVPA ASSLNS+D+FLL T +
Sbjct: 490 KGKLVIFEGGTSRKGNAEPDPPVRLFQIHGNDKSNTKAVEVPAFASSLNSNDVFLLRTQA 549

Query: 546 VCYLWFGKGCNGDQREMARVVVTVISRKNEETVLEGQEPPHFWEALGGRAPYPSNKRLPE 605
             YLW+GKG +GD+R MA+ + +++   +E TV EGQEP  FW+ LGG+ PY ++KRL +
Sbjct: 550 EHYLWYGKGSSGDERAMAKELASLLCDGSENTVAEGQEPAEFWDLLGGKTPYANDKRLQQ 609

Query: 606 EVPSFQPRLFECSSHMGCLVLAEVGFFSQEDLDKYDIMLLDTWQEIFLWLGEA--ASEWK 663
           E+   Q RLFECS+  G  V+ E+  F+Q+DL+  D+MLLDTW ++FLW+G    A+E +
Sbjct: 610 EILDVQSRLFECSNKTGQFVVTEITDFTQDDLNPTDVMLLDTWDQVFLWIGAEANATEKE 669

Query: 664 EAVAWGQEYLKTHPAGRSPATPIVLVKQGHEPPTFIGWFFTWDPYKWTSHPSHKEVVDGS 723
            A+A  Q+YL THP+GR P TPI+++KQG EPP F GWF  WDP  W++  +++++ +  
Sbjct: 670 SALATAQQYLHTHPSGRDPDTPILIIKQGFEPPIFTGWFLAWDPNIWSAGKTYEQLKEEL 729

Query: 724 PAAASTISEITAEVNNLRLSRWPGNGRAGAVALQALKGSQDSSENDLVRSPKSAGSRTSS 783
             AA+ I  ITA++ N  L                   S +S++++    P +       
Sbjct: 730 GDAAA-IMRITADMKNATL-------------------SLNSNDSEPKYYPIAV------ 763

Query: 784 SVSSTSATINGGLRREQLMHQAVEDLPEGVDPARREFYLSDSDFQDIFGKSKEEFYSMAT 843
                            L+    ++LPE V+PA++E YLS+ DF  +FG ++ +F ++  
Sbjct: 764 -----------------LLKNQNQELPEDVNPAKKENYLSEQDFVSVFGITRGQFAALPG 806

Query: 844 WRQRQEKKQLGFF 856
           W+Q Q KK+ G F
Sbjct: 807 WKQLQMKKEKGLF 819



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 86/351 (24%), Positives = 141/351 (40%), Gaps = 31/351 (8%)

Query: 379 LAAQLRMVDDGSGKVEVWCIQDLHRQPVDPKRHGQLCAGNCYLVLYTYQRLGRVQYILYL 438
           L +  R VD+  G + VW I+ +    V    HG    G+CY++L T +    +   ++ 
Sbjct: 3   LTSAFRAVDNDPGII-VWRIEKMELALVPVSAHGNFYEGDCYVILSTRRVASLLSQDIHF 61

Query: 439 WQGHQATADEIEALNSNAEELDVMYGGVLVQEHVTMGSEPPHFLAIFQGQLVIFQERAG- 497
           W G  ++ DE         +LD   GG  VQ       E   F   F+  ++  Q     
Sbjct: 62  WIGKDSSQDEQSCAAIYTTQLDDYLGGSPVQHREVQYHESDTFRGYFKQGIIYKQGGVAS 121

Query: 498 --HHGKGQSASTTRLFQVQGTDSHNTRTMEVPARASSLNSSDIFLLVTASVCYLWFGKGC 555
              H +  +    RL  V+G    N R  EV     S N  D+FLL    V   W G   
Sbjct: 122 GMKHVETNTYDVKRLLHVKG--KRNIRATEVEMSWDSFNRGDVFLLDLGKVIIQWNGPES 179

Query: 556 NGDQREMARVVVTVISRKN-----EETVLEGQE---PPHFWEALGGRAPYPS--NKRLPE 605
           N  +R  A ++   I  +      E  V+EG +    P   + L       S     +P+
Sbjct: 180 NSGERLKAMLLAKDIRDRERGGRAEIGVIEGDKEAASPELMKVLQDTLGRRSIIKPTVPD 239

Query: 606 EVPSFQPR----LFECSSHMGCLVLAEVGF--FSQEDLDKYDIMLLD-TWQEIFLWLGEA 658
           E+   + +    L+  S   G L + EV      Q+ L+  D  +LD +  +I++W G+ 
Sbjct: 240 EIIDQKQKSTIMLYHISDSAGQLAVTEVATRPLVQDLLNHDDCYILDQSGTKIYVWKGKG 299

Query: 659 ASEWKEAVAWGQEY----LKTHPAGRSPATPIVLVKQGHEPPTFIGWFFTW 705
           A++ ++  A  +      +K++P+    +T +  V  G E   F   F  W
Sbjct: 300 ATKAEKQAAMSKALGFIKMKSYPS----STNVETVNDGAESAMFKQLFQKW 346



 Score = 76.6 bits (187), Expect = 9e-14
 Identities = 79/341 (23%), Positives = 133/341 (39%), Gaps = 29/341 (8%)

Query: 12  GGLHIWISENRKMVPVPEGAYGNFFEEHCYVILHVPQSPKATQGASSDLHYWVGKQAGAE 71
           G + +W  EN ++VPV    YG F+   CY++L+   + +        L+ W G+ A  +
Sbjct: 395 GKVEVWRIENLELVPVEYQWYGFFYGGDCYLVLY---TYEVNGKPHHILYIWQGRHASQD 451

Query: 72  AQGAAEAFQQRLQDELGGQTVLHREAQGHESDCFCSYFRPGIIYRKGGLA---SDLKHVE 128
              A+      +  +  G  V  R   G E   F + F+  ++  +GG +   +      
Sbjct: 452 ELAASAYQAVEVDRQFDGAAVQVRVRMGTEPRHFMAIFKGKLVIFEGGTSRKGNAEPDPP 511

Query: 129 TNLFNIQRLLHIKGRKHVSATEVELSWNSFNKGDIFLLDLGKMMIQWNGPKTSISEKARG 188
             LF I    H   + +  A EV    +S N  D+FLL        W G  +S  E+A  
Sbjct: 512 VRLFQI----HGNDKSNTKAVEVPAFASSLNSNDVFLLRTQAEHYLWYGKGSSGDERAMA 567

Query: 189 LALTYSLRDRERGGGRAQIGVVDDEAKAPDLMQIMEAVLGRRVGSLRAATPSKDINQLQK 248
             L   L D    G    +    + A+  DL+           G    A   +   ++  
Sbjct: 568 KELASLLCD----GSENTVAEGQEPAEFWDLLG----------GKTPYANDKRLQQEILD 613

Query: 249 ANVRLYHVYEKGKDLVVLELATPPLTQDLLQEEDFYILDQGGFKIYVWQGRMSSLQERKA 308
              RL+    K    VV E+     TQD L   D  +LD    ++++W G  ++  E+++
Sbjct: 614 VQSRLFECSNKTGQFVVTEIT--DFTQDDLNPTDVMLLDTWD-QVFLWIGAEANATEKES 670

Query: 309 AFSRAVGFIQA--KGYPTYTNVEVVNDGAESAAFKQLFRTW 347
           A + A  ++     G    T + ++  G E   F   F  W
Sbjct: 671 ALATAQQYLHTHPSGRDPDTPILIIKQGFEPPIFTGWFLAW 711


>gi|162951877 scinderin isoform 1 [Homo sapiens]
          Length = 715

 Score =  505 bits (1300), Expect = e-143
 Identities = 281/715 (39%), Positives = 426/715 (59%), Gaps = 26/715 (3%)

Query: 9   GMQGGLHIWISENRKMVPVPEGAYGNFFEEHCYVILHVPQSPKATQGASSDLHYWVGKQA 68
           G Q GL +W  E  ++VPVP+ A+G+F+    Y++LH   + K ++G +  LH+W+GK+ 
Sbjct: 14  GKQAGLQVWRIEKLELVPVPQSAHGDFYVGDAYLVLH---TAKTSRGFTYHLHFWLGKEC 70

Query: 69  GAEAQGAAEAFQQRLQDELGGQTVLHREAQGHESDCFCSYFRPGIIYRKGGLASDLKHVE 128
             +   AA  F  ++ D LGG+ V +RE QG+ES+ F SYF+ G+ Y+ GG+AS L HV 
Sbjct: 71  SQDESTAAAIFTVQMDDYLGGKPVQNRELQGYESNDFVSYFKGGLKYKAGGVASGLNHVL 130

Query: 129 TNLFNIQRLLHIKGRKHVSATEVELSWNSFNKGDIFLLDLGKMMIQWNGPKTSISEKARG 188
           TN    +RLLH+KGR+ V ATEV LSW+SFNKGD F++DLG  + QW G   +  E+ + 
Sbjct: 131 TNDLTAKRLLHVKGRRVVRATEVPLSWDSFNKGDCFIIDLGTEIYQWCGSSCNKYERLKA 190

Query: 189 LALTYSLRDRERGGGRAQIGVVDDEAKAPDLMQIMEAVLGRRVGSLRAATPSKDINQLQK 248
             +   +R  ER  GR+++ VV++ ++  +L++    VLG +            I  +  
Sbjct: 191 NQVATGIRYNER-KGRSELIVVEEGSEPSELIK----VLGEKPELPDGGDDDDIIADISN 245

Query: 249 ANV-RLYHVYEKGKDLVVLELATP-PLTQDLLQEEDFYILDQGGFK-IYVWQGRMSSLQE 305
             + +LY V +    + V  +A   P +  +L  E+ +ILD G  K I+VW+G+ ++ QE
Sbjct: 246 RKMAKLYMVSDASGSMRVTVVAEENPFSMAMLLSEECFILDHGAAKQIFVWKGKDANPQE 305

Query: 306 RKAAFSRAVGFIQAKGYPTYTNVEVVNDGAESAAFKQLFRTWSEKRRRN--QKLGGRDKS 363
           RKAA   A  F+Q   Y   T ++V+ +G E+  FKQ F+ W +K + +   K+   +K 
Sbjct: 306 RKAAMKTAEEFLQQMNYSKNTQIQVLPEGGETPIFKQFFKDWRDKDQSDGFGKVYVTEKV 365

Query: 364 IHVK---LDVGKLHTQPKLAAQLRMVDDGSGKVEVWCIQDLHRQPVDPKRHGQLCAGNCY 420
             +K    D  KLH+ P++AAQ  MVDDGSGKVE+W +++  R  VD   +G+   G+CY
Sbjct: 366 AQIKQIPFDASKLHSSPQMAAQHNMVDDGSGKVEIWRVENNGRIQVDQNSYGEFYGGDCY 425

Query: 421 LVLYTYQRLGRVQYILYLWQGHQATADEIEALNSNAEELDVMYGGVLVQEHVTMGSEPPH 480
           ++LYTY R      I+Y WQG  AT DE+        +LD   GG  VQ  V+ G EP H
Sbjct: 426 IILYTYPR----GQIIYTWQGANATRDELTTSAFLTVQLDRSLGGQAVQIRVSQGKEPVH 481

Query: 481 FLAIFQGQ-LVIFQERAGHHGKGQSASTTRLFQVQGTDSHNTRTMEVPARASSLNSSDIF 539
            L++F+ + L+I++      G    A  TRLFQV+   +  TR +EV   A+SLNS+D+F
Sbjct: 482 LLSLFKDKPLIIYKNGTSKKGGQAPAPPTRLFQVRRNLASITRIVEVDVDANSLNSNDVF 541

Query: 540 LL-VTASVCYLWFGKGCNGDQREMARVVVTVISRKNEETVLEGQEPPHFWEALGGRAPYP 598
           +L +  +  Y+W GKG + ++ + A  V +V+  K    + EG+EP  FW +LGG+  Y 
Sbjct: 542 VLKLPQNSGYIWVGKGASQEEEKGAEYVASVLKCKTLR-IQEGEEPEEFWNSLGGKKDYQ 600

Query: 599 SNKRLPEEVPSFQPRLFECSSHMGCLVLAEV-GFFSQEDLDKYDIMLLDTWQEIFLWLGE 657
           ++  L  +     PRL+ CS+  G  V+ E+ G F+Q+DL + D+MLLD W++IF+W+G+
Sbjct: 601 TSPLLETQAEDHPPRLYGCSNKTGRFVIEEIPGEFTQDDLAEDDVMLLDAWEQIFIWIGK 660

Query: 658 AAS--EWKEAVAWGQEYLKTHPAGRSPATPIVLVKQGHEPPTFIGWFFTWDPYKW 710
            A+  E KE++   + YL+T P+GR   TPIV++KQGHEPPTF GWF  WD  KW
Sbjct: 661 DANEVEKKESLKSAKMYLETDPSGRDKRTPIVIIKQGHEPPTFTGWFLGWDSSKW 715


>gi|4504165 gelsolin isoform a precursor [Homo sapiens]
          Length = 782

 Score =  503 bits (1295), Expect = e-142
 Identities = 290/729 (39%), Positives = 414/729 (56%), Gaps = 28/729 (3%)

Query: 9   GMQGGLHIWISENRKMVPVPEGAYGNFFEEHCYVILHVPQSPKATQGASSDLHYWVGKQA 68
           G + GL IW  E   +VPVP   YG+FF    YVIL   Q          DLHYW+G + 
Sbjct: 63  GKEPGLQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKTVQLRNGN--LQYDLHYWLGNEC 120

Query: 69  GAEAQGAAEAFQQRLQDELGGQTVLHREAQGHESDCFCSYFRPGIIYRKGGLASDLKHVE 128
             +  GAA  F  +L D L G+ V HRE QG ES  F  YF+ G+ Y+KGG+AS  KHV 
Sbjct: 121 SQDESGAAAIFTVQLDDYLNGRAVQHREVQGFESATFLGYFKSGLKYKKGGVASGFKHVV 180

Query: 129 TNLFNIQRLLHIKGRKHVSATEVELSWNSFNKGDIFLLDLGKMMIQWNGPKTSISEKARG 188
            N   +QRL  +KGR+ V ATEV +SW SFN GD F+LDLG  + QW G  ++  E+ + 
Sbjct: 181 PNEVVVQRLFQVKGRRVVRATEVPVSWESFNNGDCFILDLGNNIHQWCGSNSNRYERLKA 240

Query: 189 LALTYSLRDRERGGGRAQIGVVDDEAKAPDLMQIMEAVLGRRVGSLRAATPSKDINQLQK 248
             ++  +RD ER  GRA++ V ++  +   ++Q    VLG +  +L A T  +D  +   
Sbjct: 241 TQVSKGIRDNER-SGRARVHVSEEGTEPEAMLQ----VLGPK-PALPAGT--EDTAKEDA 292

Query: 249 ANVRLYHVYE----KGKDLVVLELATPPLTQDLLQEEDFYILDQG-GFKIYVWQGRMSSL 303
           AN +L  +Y+     G   V L     P  Q  L+ ED +ILD G   KI+VW+G+ ++ 
Sbjct: 293 ANRKLAKLYKVSNGAGTMSVSLVADENPFAQGALKSEDCFILDHGKDGKIFVWKGKQANT 352

Query: 304 QERKAAFSRAVGFIQAKGYPTYTNVEVVNDGAESAAFKQLFRTWSEKRRRNQKLGGRDKS 363
           +ERKAA   A  FI    YP  T V V+ +G E+  FKQ F+ W +   +   LG    S
Sbjct: 353 EERKAALKTASDFITKMDYPKQTQVSVLPEGGETPLFKQFFKNWRDP-DQTDGLGLSYLS 411

Query: 364 IH------VKLDVGKLHTQPKLAAQLRMVDDGSGKVEVWCIQDLHRQPVDPKRHGQLCAG 417
            H      V  D   LHT   +AAQ  M DDG+G+ ++W I+  ++ PVDP  +GQ   G
Sbjct: 412 SHIANVERVPFDAATLHTSTAMAAQHGMDDDGTGQKQIWRIEGSNKVPVDPATYGQFYGG 471

Query: 418 NCYLVLYTYQRLGRVQYILYLWQGHQATADEIEALNSNAEELDVMYGGVLVQEHVTMGSE 477
           + Y++LY Y+  GR   I+Y WQG Q+T DE+ A      +LD   GG  VQ  V  G E
Sbjct: 472 DSYIILYNYRHGGRQGQIIYNWQGAQSTQDEVAASAILTAQLDEELGGTPVQSRVVQGKE 531

Query: 478 PPHFLAIFQGQ-LVIFQERAGHHGKGQSASTTRLFQVQGTDSHNTRTMEVPARASSLNSS 536
           P H +++F G+ ++I++      G   + ++TRLFQV+   +  TR +EV  +A +LNS+
Sbjct: 532 PAHLMSLFGGKPMIIYKGGTSREGGQTAPASTRLFQVRANSAGATRAVEVLPKAGALNSN 591

Query: 537 DIFLLVTASVCYLWFGKGCNGDQREMARVVVTVISRKNEETVLEGQEPPHFWEALGGRAP 596
           D F+L T S  YLW G G +  ++  A+ ++ V+ R     V EG EP  FWEALGG+A 
Sbjct: 592 DAFVLKTPSAAYLWVGTGASEAEKTGAQELLRVL-RAQPVQVAEGSEPDGFWEALGGKAA 650

Query: 597 YPSNKRLPE-EVPSFQPRLFECSSHMGCLVLAEV-GFFSQEDLDKYDIMLLDTWQEIFLW 654
           Y ++ RL + ++ +  PRLF CS+ +G  V+ EV G   QEDL   D+MLLDTW ++F+W
Sbjct: 651 YRTSPRLKDKKMDAHPPRLFACSNKIGRFVIEEVPGELMQEDLATDDVMLLDTWDQVFVW 710

Query: 655 LGEAASEWK--EAVAWGQEYLKTHPAGRSPATPIVLVKQGHEPPTFIGWFFTWDPYKWTS 712
           +G+ + E +  EA+   + Y++T PA R   TPI +VKQG EPP+F+GWF  WD   W+ 
Sbjct: 711 VGKDSQEEEKTEALTSAKRYIETDPANRDRRTPITVVKQGFEPPSFVGWFLGWDDDYWSV 770

Query: 713 HPSHKEVVD 721
            P  + + +
Sbjct: 771 DPLDRAMAE 779


>gi|38044288 gelsolin isoform b [Homo sapiens]
          Length = 731

 Score =  503 bits (1295), Expect = e-142
 Identities = 290/729 (39%), Positives = 414/729 (56%), Gaps = 28/729 (3%)

Query: 9   GMQGGLHIWISENRKMVPVPEGAYGNFFEEHCYVILHVPQSPKATQGASSDLHYWVGKQA 68
           G + GL IW  E   +VPVP   YG+FF    YVIL   Q          DLHYW+G + 
Sbjct: 12  GKEPGLQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKTVQLRNGN--LQYDLHYWLGNEC 69

Query: 69  GAEAQGAAEAFQQRLQDELGGQTVLHREAQGHESDCFCSYFRPGIIYRKGGLASDLKHVE 128
             +  GAA  F  +L D L G+ V HRE QG ES  F  YF+ G+ Y+KGG+AS  KHV 
Sbjct: 70  SQDESGAAAIFTVQLDDYLNGRAVQHREVQGFESATFLGYFKSGLKYKKGGVASGFKHVV 129

Query: 129 TNLFNIQRLLHIKGRKHVSATEVELSWNSFNKGDIFLLDLGKMMIQWNGPKTSISEKARG 188
            N   +QRL  +KGR+ V ATEV +SW SFN GD F+LDLG  + QW G  ++  E+ + 
Sbjct: 130 PNEVVVQRLFQVKGRRVVRATEVPVSWESFNNGDCFILDLGNNIHQWCGSNSNRYERLKA 189

Query: 189 LALTYSLRDRERGGGRAQIGVVDDEAKAPDLMQIMEAVLGRRVGSLRAATPSKDINQLQK 248
             ++  +RD ER  GRA++ V ++  +   ++Q    VLG +  +L A T  +D  +   
Sbjct: 190 TQVSKGIRDNER-SGRARVHVSEEGTEPEAMLQ----VLGPK-PALPAGT--EDTAKEDA 241

Query: 249 ANVRLYHVYE----KGKDLVVLELATPPLTQDLLQEEDFYILDQG-GFKIYVWQGRMSSL 303
           AN +L  +Y+     G   V L     P  Q  L+ ED +ILD G   KI+VW+G+ ++ 
Sbjct: 242 ANRKLAKLYKVSNGAGTMSVSLVADENPFAQGALKSEDCFILDHGKDGKIFVWKGKQANT 301

Query: 304 QERKAAFSRAVGFIQAKGYPTYTNVEVVNDGAESAAFKQLFRTWSEKRRRNQKLGGRDKS 363
           +ERKAA   A  FI    YP  T V V+ +G E+  FKQ F+ W +   +   LG    S
Sbjct: 302 EERKAALKTASDFITKMDYPKQTQVSVLPEGGETPLFKQFFKNWRDP-DQTDGLGLSYLS 360

Query: 364 IH------VKLDVGKLHTQPKLAAQLRMVDDGSGKVEVWCIQDLHRQPVDPKRHGQLCAG 417
            H      V  D   LHT   +AAQ  M DDG+G+ ++W I+  ++ PVDP  +GQ   G
Sbjct: 361 SHIANVERVPFDAATLHTSTAMAAQHGMDDDGTGQKQIWRIEGSNKVPVDPATYGQFYGG 420

Query: 418 NCYLVLYTYQRLGRVQYILYLWQGHQATADEIEALNSNAEELDVMYGGVLVQEHVTMGSE 477
           + Y++LY Y+  GR   I+Y WQG Q+T DE+ A      +LD   GG  VQ  V  G E
Sbjct: 421 DSYIILYNYRHGGRQGQIIYNWQGAQSTQDEVAASAILTAQLDEELGGTPVQSRVVQGKE 480

Query: 478 PPHFLAIFQGQ-LVIFQERAGHHGKGQSASTTRLFQVQGTDSHNTRTMEVPARASSLNSS 536
           P H +++F G+ ++I++      G   + ++TRLFQV+   +  TR +EV  +A +LNS+
Sbjct: 481 PAHLMSLFGGKPMIIYKGGTSREGGQTAPASTRLFQVRANSAGATRAVEVLPKAGALNSN 540

Query: 537 DIFLLVTASVCYLWFGKGCNGDQREMARVVVTVISRKNEETVLEGQEPPHFWEALGGRAP 596
           D F+L T S  YLW G G +  ++  A+ ++ V+ R     V EG EP  FWEALGG+A 
Sbjct: 541 DAFVLKTPSAAYLWVGTGASEAEKTGAQELLRVL-RAQPVQVAEGSEPDGFWEALGGKAA 599

Query: 597 YPSNKRLPE-EVPSFQPRLFECSSHMGCLVLAEV-GFFSQEDLDKYDIMLLDTWQEIFLW 654
           Y ++ RL + ++ +  PRLF CS+ +G  V+ EV G   QEDL   D+MLLDTW ++F+W
Sbjct: 600 YRTSPRLKDKKMDAHPPRLFACSNKIGRFVIEEVPGELMQEDLATDDVMLLDTWDQVFVW 659

Query: 655 LGEAASEWK--EAVAWGQEYLKTHPAGRSPATPIVLVKQGHEPPTFIGWFFTWDPYKWTS 712
           +G+ + E +  EA+   + Y++T PA R   TPI +VKQG EPP+F+GWF  WD   W+ 
Sbjct: 660 VGKDSQEEEKTEALTSAKRYIETDPANRDRRTPITVVKQGFEPPSFVGWFLGWDDDYWSV 719

Query: 713 HPSHKEVVD 721
            P  + + +
Sbjct: 720 DPLDRAMAE 728


>gi|189083782 gelsolin isoform c [Homo sapiens]
          Length = 742

 Score =  503 bits (1295), Expect = e-142
 Identities = 290/729 (39%), Positives = 414/729 (56%), Gaps = 28/729 (3%)

Query: 9   GMQGGLHIWISENRKMVPVPEGAYGNFFEEHCYVILHVPQSPKATQGASSDLHYWVGKQA 68
           G + GL IW  E   +VPVP   YG+FF    YVIL   Q          DLHYW+G + 
Sbjct: 23  GKEPGLQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKTVQLRNGN--LQYDLHYWLGNEC 80

Query: 69  GAEAQGAAEAFQQRLQDELGGQTVLHREAQGHESDCFCSYFRPGIIYRKGGLASDLKHVE 128
             +  GAA  F  +L D L G+ V HRE QG ES  F  YF+ G+ Y+KGG+AS  KHV 
Sbjct: 81  SQDESGAAAIFTVQLDDYLNGRAVQHREVQGFESATFLGYFKSGLKYKKGGVASGFKHVV 140

Query: 129 TNLFNIQRLLHIKGRKHVSATEVELSWNSFNKGDIFLLDLGKMMIQWNGPKTSISEKARG 188
            N   +QRL  +KGR+ V ATEV +SW SFN GD F+LDLG  + QW G  ++  E+ + 
Sbjct: 141 PNEVVVQRLFQVKGRRVVRATEVPVSWESFNNGDCFILDLGNNIHQWCGSNSNRYERLKA 200

Query: 189 LALTYSLRDRERGGGRAQIGVVDDEAKAPDLMQIMEAVLGRRVGSLRAATPSKDINQLQK 248
             ++  +RD ER  GRA++ V ++  +   ++Q    VLG +  +L A T  +D  +   
Sbjct: 201 TQVSKGIRDNER-SGRARVHVSEEGTEPEAMLQ----VLGPK-PALPAGT--EDTAKEDA 252

Query: 249 ANVRLYHVYE----KGKDLVVLELATPPLTQDLLQEEDFYILDQG-GFKIYVWQGRMSSL 303
           AN +L  +Y+     G   V L     P  Q  L+ ED +ILD G   KI+VW+G+ ++ 
Sbjct: 253 ANRKLAKLYKVSNGAGTMSVSLVADENPFAQGALKSEDCFILDHGKDGKIFVWKGKQANT 312

Query: 304 QERKAAFSRAVGFIQAKGYPTYTNVEVVNDGAESAAFKQLFRTWSEKRRRNQKLGGRDKS 363
           +ERKAA   A  FI    YP  T V V+ +G E+  FKQ F+ W +   +   LG    S
Sbjct: 313 EERKAALKTASDFITKMDYPKQTQVSVLPEGGETPLFKQFFKNWRDP-DQTDGLGLSYLS 371

Query: 364 IH------VKLDVGKLHTQPKLAAQLRMVDDGSGKVEVWCIQDLHRQPVDPKRHGQLCAG 417
            H      V  D   LHT   +AAQ  M DDG+G+ ++W I+  ++ PVDP  +GQ   G
Sbjct: 372 SHIANVERVPFDAATLHTSTAMAAQHGMDDDGTGQKQIWRIEGSNKVPVDPATYGQFYGG 431

Query: 418 NCYLVLYTYQRLGRVQYILYLWQGHQATADEIEALNSNAEELDVMYGGVLVQEHVTMGSE 477
           + Y++LY Y+  GR   I+Y WQG Q+T DE+ A      +LD   GG  VQ  V  G E
Sbjct: 432 DSYIILYNYRHGGRQGQIIYNWQGAQSTQDEVAASAILTAQLDEELGGTPVQSRVVQGKE 491

Query: 478 PPHFLAIFQGQ-LVIFQERAGHHGKGQSASTTRLFQVQGTDSHNTRTMEVPARASSLNSS 536
           P H +++F G+ ++I++      G   + ++TRLFQV+   +  TR +EV  +A +LNS+
Sbjct: 492 PAHLMSLFGGKPMIIYKGGTSREGGQTAPASTRLFQVRANSAGATRAVEVLPKAGALNSN 551

Query: 537 DIFLLVTASVCYLWFGKGCNGDQREMARVVVTVISRKNEETVLEGQEPPHFWEALGGRAP 596
           D F+L T S  YLW G G +  ++  A+ ++ V+ R     V EG EP  FWEALGG+A 
Sbjct: 552 DAFVLKTPSAAYLWVGTGASEAEKTGAQELLRVL-RAQPVQVAEGSEPDGFWEALGGKAA 610

Query: 597 YPSNKRLPE-EVPSFQPRLFECSSHMGCLVLAEV-GFFSQEDLDKYDIMLLDTWQEIFLW 654
           Y ++ RL + ++ +  PRLF CS+ +G  V+ EV G   QEDL   D+MLLDTW ++F+W
Sbjct: 611 YRTSPRLKDKKMDAHPPRLFACSNKIGRFVIEEVPGELMQEDLATDDVMLLDTWDQVFVW 670

Query: 655 LGEAASEWK--EAVAWGQEYLKTHPAGRSPATPIVLVKQGHEPPTFIGWFFTWDPYKWTS 712
           +G+ + E +  EA+   + Y++T PA R   TPI +VKQG EPP+F+GWF  WD   W+ 
Sbjct: 671 VGKDSQEEEKTEALTSAKRYIETDPANRDRRTPITVVKQGFEPPSFVGWFLGWDDDYWSV 730

Query: 713 HPSHKEVVD 721
            P  + + +
Sbjct: 731 DPLDRAMAE 739


>gi|189083780 gelsolin isoform c [Homo sapiens]
          Length = 742

 Score =  503 bits (1295), Expect = e-142
 Identities = 290/729 (39%), Positives = 414/729 (56%), Gaps = 28/729 (3%)

Query: 9   GMQGGLHIWISENRKMVPVPEGAYGNFFEEHCYVILHVPQSPKATQGASSDLHYWVGKQA 68
           G + GL IW  E   +VPVP   YG+FF    YVIL   Q          DLHYW+G + 
Sbjct: 23  GKEPGLQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKTVQLRNGN--LQYDLHYWLGNEC 80

Query: 69  GAEAQGAAEAFQQRLQDELGGQTVLHREAQGHESDCFCSYFRPGIIYRKGGLASDLKHVE 128
             +  GAA  F  +L D L G+ V HRE QG ES  F  YF+ G+ Y+KGG+AS  KHV 
Sbjct: 81  SQDESGAAAIFTVQLDDYLNGRAVQHREVQGFESATFLGYFKSGLKYKKGGVASGFKHVV 140

Query: 129 TNLFNIQRLLHIKGRKHVSATEVELSWNSFNKGDIFLLDLGKMMIQWNGPKTSISEKARG 188
            N   +QRL  +KGR+ V ATEV +SW SFN GD F+LDLG  + QW G  ++  E+ + 
Sbjct: 141 PNEVVVQRLFQVKGRRVVRATEVPVSWESFNNGDCFILDLGNNIHQWCGSNSNRYERLKA 200

Query: 189 LALTYSLRDRERGGGRAQIGVVDDEAKAPDLMQIMEAVLGRRVGSLRAATPSKDINQLQK 248
             ++  +RD ER  GRA++ V ++  +   ++Q    VLG +  +L A T  +D  +   
Sbjct: 201 TQVSKGIRDNER-SGRARVHVSEEGTEPEAMLQ----VLGPK-PALPAGT--EDTAKEDA 252

Query: 249 ANVRLYHVYE----KGKDLVVLELATPPLTQDLLQEEDFYILDQG-GFKIYVWQGRMSSL 303
           AN +L  +Y+     G   V L     P  Q  L+ ED +ILD G   KI+VW+G+ ++ 
Sbjct: 253 ANRKLAKLYKVSNGAGTMSVSLVADENPFAQGALKSEDCFILDHGKDGKIFVWKGKQANT 312

Query: 304 QERKAAFSRAVGFIQAKGYPTYTNVEVVNDGAESAAFKQLFRTWSEKRRRNQKLGGRDKS 363
           +ERKAA   A  FI    YP  T V V+ +G E+  FKQ F+ W +   +   LG    S
Sbjct: 313 EERKAALKTASDFITKMDYPKQTQVSVLPEGGETPLFKQFFKNWRDP-DQTDGLGLSYLS 371

Query: 364 IH------VKLDVGKLHTQPKLAAQLRMVDDGSGKVEVWCIQDLHRQPVDPKRHGQLCAG 417
            H      V  D   LHT   +AAQ  M DDG+G+ ++W I+  ++ PVDP  +GQ   G
Sbjct: 372 SHIANVERVPFDAATLHTSTAMAAQHGMDDDGTGQKQIWRIEGSNKVPVDPATYGQFYGG 431

Query: 418 NCYLVLYTYQRLGRVQYILYLWQGHQATADEIEALNSNAEELDVMYGGVLVQEHVTMGSE 477
           + Y++LY Y+  GR   I+Y WQG Q+T DE+ A      +LD   GG  VQ  V  G E
Sbjct: 432 DSYIILYNYRHGGRQGQIIYNWQGAQSTQDEVAASAILTAQLDEELGGTPVQSRVVQGKE 491

Query: 478 PPHFLAIFQGQ-LVIFQERAGHHGKGQSASTTRLFQVQGTDSHNTRTMEVPARASSLNSS 536
           P H +++F G+ ++I++      G   + ++TRLFQV+   +  TR +EV  +A +LNS+
Sbjct: 492 PAHLMSLFGGKPMIIYKGGTSREGGQTAPASTRLFQVRANSAGATRAVEVLPKAGALNSN 551

Query: 537 DIFLLVTASVCYLWFGKGCNGDQREMARVVVTVISRKNEETVLEGQEPPHFWEALGGRAP 596
           D F+L T S  YLW G G +  ++  A+ ++ V+ R     V EG EP  FWEALGG+A 
Sbjct: 552 DAFVLKTPSAAYLWVGTGASEAEKTGAQELLRVL-RAQPVQVAEGSEPDGFWEALGGKAA 610

Query: 597 YPSNKRLPE-EVPSFQPRLFECSSHMGCLVLAEV-GFFSQEDLDKYDIMLLDTWQEIFLW 654
           Y ++ RL + ++ +  PRLF CS+ +G  V+ EV G   QEDL   D+MLLDTW ++F+W
Sbjct: 611 YRTSPRLKDKKMDAHPPRLFACSNKIGRFVIEEVPGELMQEDLATDDVMLLDTWDQVFVW 670

Query: 655 LGEAASEWK--EAVAWGQEYLKTHPAGRSPATPIVLVKQGHEPPTFIGWFFTWDPYKWTS 712
           +G+ + E +  EA+   + Y++T PA R   TPI +VKQG EPP+F+GWF  WD   W+ 
Sbjct: 671 VGKDSQEEEKTEALTSAKRYIETDPANRDRRTPITVVKQGFEPPSFVGWFLGWDDDYWSV 730

Query: 713 HPSHKEVVD 721
            P  + + +
Sbjct: 731 DPLDRAMAE 739


>gi|189083778 gelsolin isoform b [Homo sapiens]
          Length = 731

 Score =  503 bits (1295), Expect = e-142
 Identities = 290/729 (39%), Positives = 414/729 (56%), Gaps = 28/729 (3%)

Query: 9   GMQGGLHIWISENRKMVPVPEGAYGNFFEEHCYVILHVPQSPKATQGASSDLHYWVGKQA 68
           G + GL IW  E   +VPVP   YG+FF    YVIL   Q          DLHYW+G + 
Sbjct: 12  GKEPGLQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKTVQLRNGN--LQYDLHYWLGNEC 69

Query: 69  GAEAQGAAEAFQQRLQDELGGQTVLHREAQGHESDCFCSYFRPGIIYRKGGLASDLKHVE 128
             +  GAA  F  +L D L G+ V HRE QG ES  F  YF+ G+ Y+KGG+AS  KHV 
Sbjct: 70  SQDESGAAAIFTVQLDDYLNGRAVQHREVQGFESATFLGYFKSGLKYKKGGVASGFKHVV 129

Query: 129 TNLFNIQRLLHIKGRKHVSATEVELSWNSFNKGDIFLLDLGKMMIQWNGPKTSISEKARG 188
            N   +QRL  +KGR+ V ATEV +SW SFN GD F+LDLG  + QW G  ++  E+ + 
Sbjct: 130 PNEVVVQRLFQVKGRRVVRATEVPVSWESFNNGDCFILDLGNNIHQWCGSNSNRYERLKA 189

Query: 189 LALTYSLRDRERGGGRAQIGVVDDEAKAPDLMQIMEAVLGRRVGSLRAATPSKDINQLQK 248
             ++  +RD ER  GRA++ V ++  +   ++Q    VLG +  +L A T  +D  +   
Sbjct: 190 TQVSKGIRDNER-SGRARVHVSEEGTEPEAMLQ----VLGPK-PALPAGT--EDTAKEDA 241

Query: 249 ANVRLYHVYE----KGKDLVVLELATPPLTQDLLQEEDFYILDQG-GFKIYVWQGRMSSL 303
           AN +L  +Y+     G   V L     P  Q  L+ ED +ILD G   KI+VW+G+ ++ 
Sbjct: 242 ANRKLAKLYKVSNGAGTMSVSLVADENPFAQGALKSEDCFILDHGKDGKIFVWKGKQANT 301

Query: 304 QERKAAFSRAVGFIQAKGYPTYTNVEVVNDGAESAAFKQLFRTWSEKRRRNQKLGGRDKS 363
           +ERKAA   A  FI    YP  T V V+ +G E+  FKQ F+ W +   +   LG    S
Sbjct: 302 EERKAALKTASDFITKMDYPKQTQVSVLPEGGETPLFKQFFKNWRDP-DQTDGLGLSYLS 360

Query: 364 IH------VKLDVGKLHTQPKLAAQLRMVDDGSGKVEVWCIQDLHRQPVDPKRHGQLCAG 417
            H      V  D   LHT   +AAQ  M DDG+G+ ++W I+  ++ PVDP  +GQ   G
Sbjct: 361 SHIANVERVPFDAATLHTSTAMAAQHGMDDDGTGQKQIWRIEGSNKVPVDPATYGQFYGG 420

Query: 418 NCYLVLYTYQRLGRVQYILYLWQGHQATADEIEALNSNAEELDVMYGGVLVQEHVTMGSE 477
           + Y++LY Y+  GR   I+Y WQG Q+T DE+ A      +LD   GG  VQ  V  G E
Sbjct: 421 DSYIILYNYRHGGRQGQIIYNWQGAQSTQDEVAASAILTAQLDEELGGTPVQSRVVQGKE 480

Query: 478 PPHFLAIFQGQ-LVIFQERAGHHGKGQSASTTRLFQVQGTDSHNTRTMEVPARASSLNSS 536
           P H +++F G+ ++I++      G   + ++TRLFQV+   +  TR +EV  +A +LNS+
Sbjct: 481 PAHLMSLFGGKPMIIYKGGTSREGGQTAPASTRLFQVRANSAGATRAVEVLPKAGALNSN 540

Query: 537 DIFLLVTASVCYLWFGKGCNGDQREMARVVVTVISRKNEETVLEGQEPPHFWEALGGRAP 596
           D F+L T S  YLW G G +  ++  A+ ++ V+ R     V EG EP  FWEALGG+A 
Sbjct: 541 DAFVLKTPSAAYLWVGTGASEAEKTGAQELLRVL-RAQPVQVAEGSEPDGFWEALGGKAA 599

Query: 597 YPSNKRLPE-EVPSFQPRLFECSSHMGCLVLAEV-GFFSQEDLDKYDIMLLDTWQEIFLW 654
           Y ++ RL + ++ +  PRLF CS+ +G  V+ EV G   QEDL   D+MLLDTW ++F+W
Sbjct: 600 YRTSPRLKDKKMDAHPPRLFACSNKIGRFVIEEVPGELMQEDLATDDVMLLDTWDQVFVW 659

Query: 655 LGEAASEWK--EAVAWGQEYLKTHPAGRSPATPIVLVKQGHEPPTFIGWFFTWDPYKWTS 712
           +G+ + E +  EA+   + Y++T PA R   TPI +VKQG EPP+F+GWF  WD   W+ 
Sbjct: 660 VGKDSQEEEKTEALTSAKRYIETDPANRDRRTPITVVKQGFEPPSFVGWFLGWDDDYWSV 719

Query: 713 HPSHKEVVD 721
            P  + + +
Sbjct: 720 DPLDRAMAE 728


>gi|189083776 gelsolin isoform b [Homo sapiens]
          Length = 731

 Score =  503 bits (1295), Expect = e-142
 Identities = 290/729 (39%), Positives = 414/729 (56%), Gaps = 28/729 (3%)

Query: 9   GMQGGLHIWISENRKMVPVPEGAYGNFFEEHCYVILHVPQSPKATQGASSDLHYWVGKQA 68
           G + GL IW  E   +VPVP   YG+FF    YVIL   Q          DLHYW+G + 
Sbjct: 12  GKEPGLQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKTVQLRNGN--LQYDLHYWLGNEC 69

Query: 69  GAEAQGAAEAFQQRLQDELGGQTVLHREAQGHESDCFCSYFRPGIIYRKGGLASDLKHVE 128
             +  GAA  F  +L D L G+ V HRE QG ES  F  YF+ G+ Y+KGG+AS  KHV 
Sbjct: 70  SQDESGAAAIFTVQLDDYLNGRAVQHREVQGFESATFLGYFKSGLKYKKGGVASGFKHVV 129

Query: 129 TNLFNIQRLLHIKGRKHVSATEVELSWNSFNKGDIFLLDLGKMMIQWNGPKTSISEKARG 188
            N   +QRL  +KGR+ V ATEV +SW SFN GD F+LDLG  + QW G  ++  E+ + 
Sbjct: 130 PNEVVVQRLFQVKGRRVVRATEVPVSWESFNNGDCFILDLGNNIHQWCGSNSNRYERLKA 189

Query: 189 LALTYSLRDRERGGGRAQIGVVDDEAKAPDLMQIMEAVLGRRVGSLRAATPSKDINQLQK 248
             ++  +RD ER  GRA++ V ++  +   ++Q    VLG +  +L A T  +D  +   
Sbjct: 190 TQVSKGIRDNER-SGRARVHVSEEGTEPEAMLQ----VLGPK-PALPAGT--EDTAKEDA 241

Query: 249 ANVRLYHVYE----KGKDLVVLELATPPLTQDLLQEEDFYILDQG-GFKIYVWQGRMSSL 303
           AN +L  +Y+     G   V L     P  Q  L+ ED +ILD G   KI+VW+G+ ++ 
Sbjct: 242 ANRKLAKLYKVSNGAGTMSVSLVADENPFAQGALKSEDCFILDHGKDGKIFVWKGKQANT 301

Query: 304 QERKAAFSRAVGFIQAKGYPTYTNVEVVNDGAESAAFKQLFRTWSEKRRRNQKLGGRDKS 363
           +ERKAA   A  FI    YP  T V V+ +G E+  FKQ F+ W +   +   LG    S
Sbjct: 302 EERKAALKTASDFITKMDYPKQTQVSVLPEGGETPLFKQFFKNWRDP-DQTDGLGLSYLS 360

Query: 364 IH------VKLDVGKLHTQPKLAAQLRMVDDGSGKVEVWCIQDLHRQPVDPKRHGQLCAG 417
            H      V  D   LHT   +AAQ  M DDG+G+ ++W I+  ++ PVDP  +GQ   G
Sbjct: 361 SHIANVERVPFDAATLHTSTAMAAQHGMDDDGTGQKQIWRIEGSNKVPVDPATYGQFYGG 420

Query: 418 NCYLVLYTYQRLGRVQYILYLWQGHQATADEIEALNSNAEELDVMYGGVLVQEHVTMGSE 477
           + Y++LY Y+  GR   I+Y WQG Q+T DE+ A      +LD   GG  VQ  V  G E
Sbjct: 421 DSYIILYNYRHGGRQGQIIYNWQGAQSTQDEVAASAILTAQLDEELGGTPVQSRVVQGKE 480

Query: 478 PPHFLAIFQGQ-LVIFQERAGHHGKGQSASTTRLFQVQGTDSHNTRTMEVPARASSLNSS 536
           P H +++F G+ ++I++      G   + ++TRLFQV+   +  TR +EV  +A +LNS+
Sbjct: 481 PAHLMSLFGGKPMIIYKGGTSREGGQTAPASTRLFQVRANSAGATRAVEVLPKAGALNSN 540

Query: 537 DIFLLVTASVCYLWFGKGCNGDQREMARVVVTVISRKNEETVLEGQEPPHFWEALGGRAP 596
           D F+L T S  YLW G G +  ++  A+ ++ V+ R     V EG EP  FWEALGG+A 
Sbjct: 541 DAFVLKTPSAAYLWVGTGASEAEKTGAQELLRVL-RAQPVQVAEGSEPDGFWEALGGKAA 599

Query: 597 YPSNKRLPE-EVPSFQPRLFECSSHMGCLVLAEV-GFFSQEDLDKYDIMLLDTWQEIFLW 654
           Y ++ RL + ++ +  PRLF CS+ +G  V+ EV G   QEDL   D+MLLDTW ++F+W
Sbjct: 600 YRTSPRLKDKKMDAHPPRLFACSNKIGRFVIEEVPGELMQEDLATDDVMLLDTWDQVFVW 659

Query: 655 LGEAASEWK--EAVAWGQEYLKTHPAGRSPATPIVLVKQGHEPPTFIGWFFTWDPYKWTS 712
           +G+ + E +  EA+   + Y++T PA R   TPI +VKQG EPP+F+GWF  WD   W+ 
Sbjct: 660 VGKDSQEEEKTEALTSAKRYIETDPANRDRRTPITVVKQGFEPPSFVGWFLGWDDDYWSV 719

Query: 713 HPSHKEVVD 721
            P  + + +
Sbjct: 720 DPLDRAMAE 728


>gi|189083774 gelsolin isoform b [Homo sapiens]
          Length = 731

 Score =  503 bits (1295), Expect = e-142
 Identities = 290/729 (39%), Positives = 414/729 (56%), Gaps = 28/729 (3%)

Query: 9   GMQGGLHIWISENRKMVPVPEGAYGNFFEEHCYVILHVPQSPKATQGASSDLHYWVGKQA 68
           G + GL IW  E   +VPVP   YG+FF    YVIL   Q          DLHYW+G + 
Sbjct: 12  GKEPGLQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKTVQLRNGN--LQYDLHYWLGNEC 69

Query: 69  GAEAQGAAEAFQQRLQDELGGQTVLHREAQGHESDCFCSYFRPGIIYRKGGLASDLKHVE 128
             +  GAA  F  +L D L G+ V HRE QG ES  F  YF+ G+ Y+KGG+AS  KHV 
Sbjct: 70  SQDESGAAAIFTVQLDDYLNGRAVQHREVQGFESATFLGYFKSGLKYKKGGVASGFKHVV 129

Query: 129 TNLFNIQRLLHIKGRKHVSATEVELSWNSFNKGDIFLLDLGKMMIQWNGPKTSISEKARG 188
            N   +QRL  +KGR+ V ATEV +SW SFN GD F+LDLG  + QW G  ++  E+ + 
Sbjct: 130 PNEVVVQRLFQVKGRRVVRATEVPVSWESFNNGDCFILDLGNNIHQWCGSNSNRYERLKA 189

Query: 189 LALTYSLRDRERGGGRAQIGVVDDEAKAPDLMQIMEAVLGRRVGSLRAATPSKDINQLQK 248
             ++  +RD ER  GRA++ V ++  +   ++Q    VLG +  +L A T  +D  +   
Sbjct: 190 TQVSKGIRDNER-SGRARVHVSEEGTEPEAMLQ----VLGPK-PALPAGT--EDTAKEDA 241

Query: 249 ANVRLYHVYE----KGKDLVVLELATPPLTQDLLQEEDFYILDQG-GFKIYVWQGRMSSL 303
           AN +L  +Y+     G   V L     P  Q  L+ ED +ILD G   KI+VW+G+ ++ 
Sbjct: 242 ANRKLAKLYKVSNGAGTMSVSLVADENPFAQGALKSEDCFILDHGKDGKIFVWKGKQANT 301

Query: 304 QERKAAFSRAVGFIQAKGYPTYTNVEVVNDGAESAAFKQLFRTWSEKRRRNQKLGGRDKS 363
           +ERKAA   A  FI    YP  T V V+ +G E+  FKQ F+ W +   +   LG    S
Sbjct: 302 EERKAALKTASDFITKMDYPKQTQVSVLPEGGETPLFKQFFKNWRDP-DQTDGLGLSYLS 360

Query: 364 IH------VKLDVGKLHTQPKLAAQLRMVDDGSGKVEVWCIQDLHRQPVDPKRHGQLCAG 417
            H      V  D   LHT   +AAQ  M DDG+G+ ++W I+  ++ PVDP  +GQ   G
Sbjct: 361 SHIANVERVPFDAATLHTSTAMAAQHGMDDDGTGQKQIWRIEGSNKVPVDPATYGQFYGG 420

Query: 418 NCYLVLYTYQRLGRVQYILYLWQGHQATADEIEALNSNAEELDVMYGGVLVQEHVTMGSE 477
           + Y++LY Y+  GR   I+Y WQG Q+T DE+ A      +LD   GG  VQ  V  G E
Sbjct: 421 DSYIILYNYRHGGRQGQIIYNWQGAQSTQDEVAASAILTAQLDEELGGTPVQSRVVQGKE 480

Query: 478 PPHFLAIFQGQ-LVIFQERAGHHGKGQSASTTRLFQVQGTDSHNTRTMEVPARASSLNSS 536
           P H +++F G+ ++I++      G   + ++TRLFQV+   +  TR +EV  +A +LNS+
Sbjct: 481 PAHLMSLFGGKPMIIYKGGTSREGGQTAPASTRLFQVRANSAGATRAVEVLPKAGALNSN 540

Query: 537 DIFLLVTASVCYLWFGKGCNGDQREMARVVVTVISRKNEETVLEGQEPPHFWEALGGRAP 596
           D F+L T S  YLW G G +  ++  A+ ++ V+ R     V EG EP  FWEALGG+A 
Sbjct: 541 DAFVLKTPSAAYLWVGTGASEAEKTGAQELLRVL-RAQPVQVAEGSEPDGFWEALGGKAA 599

Query: 597 YPSNKRLPE-EVPSFQPRLFECSSHMGCLVLAEV-GFFSQEDLDKYDIMLLDTWQEIFLW 654
           Y ++ RL + ++ +  PRLF CS+ +G  V+ EV G   QEDL   D+MLLDTW ++F+W
Sbjct: 600 YRTSPRLKDKKMDAHPPRLFACSNKIGRFVIEEVPGELMQEDLATDDVMLLDTWDQVFVW 659

Query: 655 LGEAASEWK--EAVAWGQEYLKTHPAGRSPATPIVLVKQGHEPPTFIGWFFTWDPYKWTS 712
           +G+ + E +  EA+   + Y++T PA R   TPI +VKQG EPP+F+GWF  WD   W+ 
Sbjct: 660 VGKDSQEEEKTEALTSAKRYIETDPANRDRRTPITVVKQGFEPPSFVGWFLGWDDDYWSV 719

Query: 713 HPSHKEVVD 721
            P  + + +
Sbjct: 720 DPLDRAMAE 728


>gi|189083772 gelsolin isoform b [Homo sapiens]
          Length = 731

 Score =  503 bits (1295), Expect = e-142
 Identities = 290/729 (39%), Positives = 414/729 (56%), Gaps = 28/729 (3%)

Query: 9   GMQGGLHIWISENRKMVPVPEGAYGNFFEEHCYVILHVPQSPKATQGASSDLHYWVGKQA 68
           G + GL IW  E   +VPVP   YG+FF    YVIL   Q          DLHYW+G + 
Sbjct: 12  GKEPGLQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKTVQLRNGN--LQYDLHYWLGNEC 69

Query: 69  GAEAQGAAEAFQQRLQDELGGQTVLHREAQGHESDCFCSYFRPGIIYRKGGLASDLKHVE 128
             +  GAA  F  +L D L G+ V HRE QG ES  F  YF+ G+ Y+KGG+AS  KHV 
Sbjct: 70  SQDESGAAAIFTVQLDDYLNGRAVQHREVQGFESATFLGYFKSGLKYKKGGVASGFKHVV 129

Query: 129 TNLFNIQRLLHIKGRKHVSATEVELSWNSFNKGDIFLLDLGKMMIQWNGPKTSISEKARG 188
            N   +QRL  +KGR+ V ATEV +SW SFN GD F+LDLG  + QW G  ++  E+ + 
Sbjct: 130 PNEVVVQRLFQVKGRRVVRATEVPVSWESFNNGDCFILDLGNNIHQWCGSNSNRYERLKA 189

Query: 189 LALTYSLRDRERGGGRAQIGVVDDEAKAPDLMQIMEAVLGRRVGSLRAATPSKDINQLQK 248
             ++  +RD ER  GRA++ V ++  +   ++Q    VLG +  +L A T  +D  +   
Sbjct: 190 TQVSKGIRDNER-SGRARVHVSEEGTEPEAMLQ----VLGPK-PALPAGT--EDTAKEDA 241

Query: 249 ANVRLYHVYE----KGKDLVVLELATPPLTQDLLQEEDFYILDQG-GFKIYVWQGRMSSL 303
           AN +L  +Y+     G   V L     P  Q  L+ ED +ILD G   KI+VW+G+ ++ 
Sbjct: 242 ANRKLAKLYKVSNGAGTMSVSLVADENPFAQGALKSEDCFILDHGKDGKIFVWKGKQANT 301

Query: 304 QERKAAFSRAVGFIQAKGYPTYTNVEVVNDGAESAAFKQLFRTWSEKRRRNQKLGGRDKS 363
           +ERKAA   A  FI    YP  T V V+ +G E+  FKQ F+ W +   +   LG    S
Sbjct: 302 EERKAALKTASDFITKMDYPKQTQVSVLPEGGETPLFKQFFKNWRDP-DQTDGLGLSYLS 360

Query: 364 IH------VKLDVGKLHTQPKLAAQLRMVDDGSGKVEVWCIQDLHRQPVDPKRHGQLCAG 417
            H      V  D   LHT   +AAQ  M DDG+G+ ++W I+  ++ PVDP  +GQ   G
Sbjct: 361 SHIANVERVPFDAATLHTSTAMAAQHGMDDDGTGQKQIWRIEGSNKVPVDPATYGQFYGG 420

Query: 418 NCYLVLYTYQRLGRVQYILYLWQGHQATADEIEALNSNAEELDVMYGGVLVQEHVTMGSE 477
           + Y++LY Y+  GR   I+Y WQG Q+T DE+ A      +LD   GG  VQ  V  G E
Sbjct: 421 DSYIILYNYRHGGRQGQIIYNWQGAQSTQDEVAASAILTAQLDEELGGTPVQSRVVQGKE 480

Query: 478 PPHFLAIFQGQ-LVIFQERAGHHGKGQSASTTRLFQVQGTDSHNTRTMEVPARASSLNSS 536
           P H +++F G+ ++I++      G   + ++TRLFQV+   +  TR +EV  +A +LNS+
Sbjct: 481 PAHLMSLFGGKPMIIYKGGTSREGGQTAPASTRLFQVRANSAGATRAVEVLPKAGALNSN 540

Query: 537 DIFLLVTASVCYLWFGKGCNGDQREMARVVVTVISRKNEETVLEGQEPPHFWEALGGRAP 596
           D F+L T S  YLW G G +  ++  A+ ++ V+ R     V EG EP  FWEALGG+A 
Sbjct: 541 DAFVLKTPSAAYLWVGTGASEAEKTGAQELLRVL-RAQPVQVAEGSEPDGFWEALGGKAA 599

Query: 597 YPSNKRLPE-EVPSFQPRLFECSSHMGCLVLAEV-GFFSQEDLDKYDIMLLDTWQEIFLW 654
           Y ++ RL + ++ +  PRLF CS+ +G  V+ EV G   QEDL   D+MLLDTW ++F+W
Sbjct: 600 YRTSPRLKDKKMDAHPPRLFACSNKIGRFVIEEVPGELMQEDLATDDVMLLDTWDQVFVW 659

Query: 655 LGEAASEWK--EAVAWGQEYLKTHPAGRSPATPIVLVKQGHEPPTFIGWFFTWDPYKWTS 712
           +G+ + E +  EA+   + Y++T PA R   TPI +VKQG EPP+F+GWF  WD   W+ 
Sbjct: 660 VGKDSQEEEKTEALTSAKRYIETDPANRDRRTPITVVKQGFEPPSFVGWFLGWDDDYWSV 719

Query: 713 HPSHKEVVD 721
            P  + + +
Sbjct: 720 DPLDRAMAE 728


>gi|14916473 scinderin isoform 2 [Homo sapiens]
          Length = 468

 Score =  340 bits (873), Expect = 3e-93
 Identities = 188/471 (39%), Positives = 281/471 (59%), Gaps = 17/471 (3%)

Query: 252 RLYHVYEKGKDLVVLELATP-PLTQDLLQEEDFYILDQGGFK-IYVWQGRMSSLQERKAA 309
           +LY V +    + V  +A   P +  +L  E+ +ILD G  K I+VW+G+ ++ QERKAA
Sbjct: 3   KLYMVSDASGSMRVTVVAEENPFSMAMLLSEECFILDHGAAKQIFVWKGKDANPQERKAA 62

Query: 310 FSRAVGFIQAKGYPTYTNVEVVNDGAESAAFKQLFRTWSEKRRRNQ--KLGGRDKSIHVK 367
              A  F+Q   Y   T ++V+ +G E+  FKQ F+ W +K + +   K+   +K   +K
Sbjct: 63  MKTAEEFLQQMNYSKNTQIQVLPEGGETPIFKQFFKDWRDKDQSDGFGKVYVTEKVAQIK 122

Query: 368 ---LDVGKLHTQPKLAAQLRMVDDGSGKVEVWCIQDLHRQPVDPKRHGQLCAGNCYLVLY 424
               D  KLH+ P++AAQ  MVDDGSGKVE+W +++  R  VD   +G+   G+CY++LY
Sbjct: 123 QIPFDASKLHSSPQMAAQHNMVDDGSGKVEIWRVENNGRIQVDQNSYGEFYGGDCYIILY 182

Query: 425 TYQRLGRVQYILYLWQGHQATADEIEALNSNAEELDVMYGGVLVQEHVTMGSEPPHFLAI 484
           TY R      I+Y WQG  AT DE+        +LD   GG  VQ  V+ G EP H L++
Sbjct: 183 TYPR----GQIIYTWQGANATRDELTTSAFLTVQLDRSLGGQAVQIRVSQGKEPVHLLSL 238

Query: 485 FQGQ-LVIFQERAGHHGKGQSASTTRLFQVQGTDSHNTRTMEVPARASSLNSSDIFLL-V 542
           F+ + L+I++      G    A  TRLFQV+   +  TR +EV   A+SLNS+D+F+L +
Sbjct: 239 FKDKPLIIYKNGTSKKGGQAPAPPTRLFQVRRNLASITRIVEVDVDANSLNSNDVFVLKL 298

Query: 543 TASVCYLWFGKGCNGDQREMARVVVTVISRKNEETVLEGQEPPHFWEALGGRAPYPSNKR 602
             +  Y+W GKG + ++ + A  V +V+  K    + EG+EP  FW +LGG+  Y ++  
Sbjct: 299 PQNSGYIWVGKGASQEEEKGAEYVASVLKCKTLR-IQEGEEPEEFWNSLGGKKDYQTSPL 357

Query: 603 LPEEVPSFQPRLFECSSHMGCLVLAEV-GFFSQEDLDKYDIMLLDTWQEIFLWLGEAAS- 660
           L  +     PRL+ CS+  G  V+ E+ G F+Q+DL + D+MLLD W++IF+W+G+ A+ 
Sbjct: 358 LETQAEDHPPRLYGCSNKTGRFVIEEIPGEFTQDDLAEDDVMLLDAWEQIFIWIGKDANE 417

Query: 661 -EWKEAVAWGQEYLKTHPAGRSPATPIVLVKQGHEPPTFIGWFFTWDPYKW 710
            E KE++   + YL+T P+GR   TPIV++KQGHEPPTF GWF  WD  KW
Sbjct: 418 VEKKESLKSAKMYLETDPSGRDKRTPIVIIKQGHEPPTFTGWFLGWDSSKW 468



 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 91/355 (25%), Positives = 143/355 (40%), Gaps = 51/355 (14%)

Query: 12  GGLHIWISENRKMVPVPEGAYGNFFEEHCYVILHVPQSPKATQGASSDLHYWVGKQAGAE 71
           G + IW  EN   + V + +YG F+   CY+IL+       T      ++ W G  A  +
Sbjct: 149 GKVEIWRVENNGRIQVDQNSYGEFYGGDCYIILY-------TYPRGQIIYTWQGANATRD 201

Query: 72  AQGAAEAFQQRLQDELGGQTVLHREAQGHESDCFCSYF--RPGIIY-----RKGGLA--- 121
               +     +L   LGGQ V  R +QG E     S F  +P IIY     +KGG A   
Sbjct: 202 ELTTSAFLTVQLDRSLGGQAVQIRVSQGKEPVHLLSLFKDKPLIIYKNGTSKKGGQAPAP 261

Query: 122 -SDLKHVETNLFNIQRLLHIKGRKHVSATEVELSWNSFNKGDIFLLDLGKMM-IQWNGPK 179
            + L  V  NL +I R++           EV++  NS N  D+F+L L +     W G  
Sbjct: 262 PTRLFQVRRNLASITRIV-----------EVDVDANSLNSNDVFVLKLPQNSGYIWVGKG 310

Query: 180 TSISEKARGLALTYSLRDRERGGGRAQIGVVDDEAKAPDLMQIMEAVLGRRVGSLRAATP 239
            S  E+     +   L+ +     R Q G   +E                 +G  +    
Sbjct: 311 ASQEEEKGAEYVASVLKCKTL---RIQEGEEPEE-------------FWNSLGGKKDYQT 354

Query: 240 SKDI-NQLQKANVRLYHVYEKGKDLVVLELATPPLTQDLLQEEDFYILDQGGFKIYVWQG 298
           S  +  Q +    RLY    K    V+ E+     TQD L E+D  +LD    +I++W G
Sbjct: 355 SPLLETQAEDHPPRLYGCSNKTGRFVIEEI-PGEFTQDDLAEDDVMLLD-AWEQIFIWIG 412

Query: 299 RMSSLQERKAAFSRAVGFIQA--KGYPTYTNVEVVNDGAESAAFKQLFRTWSEKR 351
           + ++  E+K +   A  +++    G    T + ++  G E   F   F  W   +
Sbjct: 413 KDANEVEKKESLKSAKMYLETDPSGRDKRTPIVIIKQGHEPPTFTGWFLGWDSSK 467


>gi|63252913 gelsolin-like capping protein [Homo sapiens]
          Length = 348

 Score =  211 bits (536), Expect = 3e-54
 Identities = 129/341 (37%), Positives = 193/341 (56%), Gaps = 19/341 (5%)

Query: 13  GLHIWISENRKMVPVPEGAYGNFFEEHCYVILHVPQSPKATQGASSDLHYWVGKQAGAEA 72
           GLH+W  E  K VPV +   G FF    Y++LH    P+      S LH W+G+Q+  + 
Sbjct: 20  GLHVWRVEKLKPVPVAQENQGVFFSGDSYLVLH--NGPEEV----SHLHLWIGQQSSRDE 73

Query: 73  QGAAEAFQQRLQDELGGQTVLHREAQGHESDCFCSYFRPGIIYRKGGLASDLKHVETNL- 131
           QGA       L   LG + V HRE QG+ESD F SYF  G+ Y++GG+ S      T   
Sbjct: 74  QGACAVLAVHLNTLLGERPVQHREVQGNESDLFMSYFPRGLKYQEGGVESAFHKTSTGAP 133

Query: 132 FNIQRLLHIKGRKHVSATEVELSWNSFNKGDIFLLDLGKMMIQWNGPKTSISEKARGLAL 191
             I++L  +KG+K++ ATE  L+W+SFN GD F+LDLG+ +  W G K++I E+ +   L
Sbjct: 134 AAIKKLYQVKGKKNIRATERALNWDSFNTGDCFILDLGQNIFAWCGGKSNILERNKARDL 193

Query: 192 TYSLRDRERGGGRAQIGVVDDEAKAPDLMQIMEAVLGRRVGSLRAATPSKDINQLQKANV 251
             ++RD ER  G+AQ+ +V D  +  +++Q    VLG +  +L+   P +D+    KAN 
Sbjct: 194 ALAIRDSER-QGKAQVEIVTDGEEPAEMIQ----VLGPK-PALKEGNPEEDLT-ADKANA 246

Query: 252 R---LYHVYEKGKDLVVLELA-TPPLTQDLLQEEDFYILDQG-GFKIYVWQGRMSSLQER 306
           +   LY V +    + + ++A + P   +LL  +D ++LD G   KIY+W+GR ++ +ER
Sbjct: 247 QAAALYKVSDATGQMNLTKVADSSPFALELLISDDCFVLDNGLCGKIYIWKGRKANEKER 306

Query: 307 KAAFSRAVGFIQAKGYPTYTNVEVVNDGAESAAFKQLFRTW 347
           +AA   A GFI    Y   T VE++  G ES  FKQ F+ W
Sbjct: 307 QAALQVAEGFISRMQYAPNTQVEILPQGHESPIFKQFFKDW 347



 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 89/332 (26%), Positives = 139/332 (41%), Gaps = 24/332 (7%)

Query: 393 VEVWCIQDLHRQPVDPKRHGQLCAGNCYLVLYTYQRLGRVQYILYLWQGHQATADEIEAL 452
           + VW ++ L   PV  +  G   +G+ YLVL+       V + L+LW G Q++ DE  A 
Sbjct: 21  LHVWRVEKLKPVPVAQENQGVFFSGDSYLVLHNGPE--EVSH-LHLWIGQQSSRDEQGAC 77

Query: 453 NSNAEELDVMYGGVLVQEHVTMGSEPPHFLAIFQGQLVIFQ---ERAGHH-GKGQSASTT 508
              A  L+ + G   VQ     G+E   F++ F   L   +   E A H    G  A+  
Sbjct: 78  AVLAVHLNTLLGERPVQHREVQGNESDLFMSYFPRGLKYQEGGVESAFHKTSTGAPAAIK 137

Query: 509 RLFQVQGTDSHNTRTMEVPARASSLNSSDIFLLVTASVCYLWFGKGCNGDQREMARVVVT 568
           +L+QV+G    N R  E      S N+ D F+L      + W G   N  +R  AR +  
Sbjct: 138 KLYQVKG--KKNIRATERALNWDSFNTGDCFILDLGQNIFAWCGGKSNILERNKARDLAL 195

Query: 569 VI------SRKNEETVLEGQEPPHFWEALGGRAPY----PSNKRLPEEVPSFQPRLFECS 618
            I       +   E V +G+EP    + LG +       P      ++  +    L++ S
Sbjct: 196 AIRDSERQGKAQVEIVTDGEEPAEMIQVLGPKPALKEGNPEEDLTADKANAQAAALYKVS 255

Query: 619 SHMGCLVLAEVGF---FSQEDLDKYDIMLLDT--WQEIFLWLGEAASEWKEAVAWGQEYL 673
              G + L +V     F+ E L   D  +LD     +I++W G  A+E +   A      
Sbjct: 256 DATGQMNLTKVADSSPFALELLISDDCFVLDNGLCGKIYIWKGRKANEKERQAALQVAEG 315

Query: 674 KTHPAGRSPATPIVLVKQGHEPPTFIGWFFTW 705
                  +P T + ++ QGHE P F  +F  W
Sbjct: 316 FISRMQYAPNTQVEILPQGHESPIFKQFFKDW 347


>gi|4503743 flightless I homolog [Homo sapiens]
          Length = 1269

 Score =  181 bits (460), Expect = 2e-45
 Identities = 192/792 (24%), Positives = 321/792 (40%), Gaps = 115/792 (14%)

Query: 9    GMQGGLHIWISENRKMVPVPEGAYGNFFEEHCYVILHVPQSPKATQGASSDLHYWVGKQA 68
            G   GL IW  EN   V V E  +G F+E  CY++L        +   + +++YW+G +A
Sbjct: 496  GQLPGLTIWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGS--LNWEIYYWIGGEA 553

Query: 69   GAEAQGAAEAFQQRLQDELGGQTVLHREAQGHESDCFCSYFRPGIIYRKGGLASDLKHVE 128
              + +  +      L++ LG +    RE  G ES+ F   F   I Y +GG AS    VE
Sbjct: 554  TLDKKACSAIHAVNLRNYLGAECRTVREEMGDESEEFLQVFDNDISYIEGGTASGFYTVE 613

Query: 129  TNLFNIQRLLHIKGRKHVSATEVELSWNSFNKGDIFLLDLGKMMIQWNGPKTSISEKARG 188
               + + R+  + G+K++    V L   S +   +FLLD G  +  W G + ++S   + 
Sbjct: 614  DTHY-VTRMYRVYGKKNIKLEPVPLKGTSLDPRFVFLLDRGLDIYVWRGAQATLSSTTKA 672

Query: 189  LALTYSLRDRERGGGRAQIGVVDDEAKAPDLMQIMEAVLGRRVGSLRAATPSK------- 241
                  +   ER  G+A+I ++    + P+  +     LG     ++   P         
Sbjct: 673  RLFAEKINKNER-KGKAEITLLVQGQELPEFWE----ALGGEPSEIKKHVPEDFWPPQPK 727

Query: 242  --------DINQLQKANVRLYHVYEKGKDLVVLELATPPLTQDLLQEEDFYILDQGGFKI 293
                       +L + N +L  V  K +  V L +    L Q LL     YILD     +
Sbjct: 728  LYKVGLGLGYLELPQINYKL-SVEHKQRPKVEL-MPRMRLLQSLLDTRCVYILDCWS-DV 784

Query: 294  YVWQGRMSSLQERKAAFSRAVGFIQAKGYPTYTNVEVVNDGAESAAFKQLFRTWSE---- 349
            ++W GR S    R AA             P +  V    +G E+  FK  F+ W +    
Sbjct: 785  FIWLGRKSPRLVRAAALKLGQELCGMLHRPRHATVSRSLEGTEAQVFKAKFKNWDDVLTV 844

Query: 350  --KRRRNQKLGGRDKSIHVKLDVGK------------LHTQP--KLAAQLRMVDDGS--- 390
               R     L     S  VK D  K            L  QP   LA   +++++ +   
Sbjct: 845  DYTRNAEAVLQSPGLSGKVKRDAEKKDQMKADLTALFLPRQPPMSLAEAEQLMEEWNEDL 904

Query: 391  GKVEVWCIQDLHRQPVDPKRHGQLCAGNCYLVLYTY------------------------ 426
              +E + ++      +  +  G     +CY+ L  Y                        
Sbjct: 905  DGMEGFVLEGKKFARLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKKEDKEEKAEGKEG 964

Query: 427  ----------QRLGRVQYILYLWQGHQAT-ADEIEALNSNAEELDVMYGGVLVQEHVTMG 475
                      Q     Q I+Y WQG +A+    +    S  ++ + ++ G L    +T  
Sbjct: 965  EEATAEAEEKQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVVRMTQQ 1024

Query: 476  SEPPHFLAIFQGQLVIFQERAGHHGKG---QSASTTRLFQVQGTDSH-NTRTMEVPARAS 531
             E P FL+ F+ + +I      H GK    Q A    L+Q++   S   TR +++   +S
Sbjct: 1025 QENPKFLSHFKRKFII------HRGKRKAVQGAQQPSLYQIRTNGSALCTRCIQINTDSS 1078

Query: 532  SLNSSDIFLLV-------TASVCYLWFGKGCNGDQREMARVVVTVI--SRKNEETVLEGQ 582
             LNS   F+L           + Y W G+  + D+ ++A  ++  +  +  +++ + EG+
Sbjct: 1079 LLNSEFCFILKVPFESEDNQGIVYAWVGRASDPDEAKLAEDILNTMFDTSYSKQVINEGE 1138

Query: 583  EPPH-FWEALGGRAPYPSNKRLPEEVPSFQPRLFECSSHMGCLVLAE-VGFFSQEDLDKY 640
            EP + FW  +G + PY  +    +       RLF CS+  G   + E    F Q+DL   
Sbjct: 1139 EPENFFWVGIGAQKPYDDDAEYMKHT-----RLFRCSNEKGYFAVTEKCSDFCQDDLADD 1193

Query: 641  DIMLLDTWQEIFLWLGEAAS--EWKEAVAWGQEYLKTHPAGRSPATP--IVLVKQGHEPP 696
            DIMLLD  QE+++W+G   S  E K ++   Q Y++ H   +    P  + LV++G+E  
Sbjct: 1194 DIMLLDNGQEVYMWVGTQTSQVEIKLSLKACQVYIQ-HMRSKEHERPRRLRLVRKGNEQH 1252

Query: 697  TFIGWFFTWDPY 708
             F   F  W  +
Sbjct: 1253 AFTRCFHAWSAF 1264



 Score =  114 bits (285), Expect = 4e-25
 Identities = 117/469 (24%), Positives = 189/469 (40%), Gaps = 52/469 (11%)

Query: 333 DGAESAAFKQLFRTWSEKRRRNQKLGGRDKSIHVKLDVGKLHT------QPKLAAQLRMV 386
           D A+    KQ+ +  S+  +   K   +++S   +   GK+        +P+L       
Sbjct: 435 DSAQDDQAKQVLKGMSDVAQEKNKK--QEESADARAPSGKVRRWDQGLEKPRLDYSEFFT 492

Query: 387 DDGSGK--VEVWCIQDLHRQPVDPKRHGQLCAGNCYLVLYTY-QRLGRVQYILYLWQGHQ 443
           +D      + +W I++     V+   HG+    +CY+VL T+    G + + +Y W G +
Sbjct: 493 EDVGQLPGLTIWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGSLNWEIYYWIGGE 552

Query: 444 ATADEIEALNSNAEELDVMYGGVLVQEHVTMGSEPPHFLAIFQGQLVIFQ--ERAGHHGK 501
           AT D+      +A  L    G         MG E   FL +F   +   +    +G +  
Sbjct: 553 ATLDKKACSAIHAVNLRNYLGAECRTVREEMGDESEEFLQVFDNDISYIEGGTASGFYTV 612

Query: 502 GQSASTTRLFQVQGTDSHNTRTMEVPARASSLNSSDIFLLVTASVCYLWFGKGCNGDQRE 561
             +   TR+++V G    N +   VP + +SL+   +FLL      Y+W G         
Sbjct: 613 EDTHYVTRMYRVYG--KKNIKLEPVPLKGTSLDPRFVFLLDRGLDIYVWRGAQATLSSTT 670

Query: 562 MARVVVTVISR-----KNEETVL-EGQEPPHFWEALGGRAPYPSNKRLPEEVPSFQPRLF 615
            AR+    I++     K E T+L +GQE P FWEALGG  P    K +PE+    QP+L+
Sbjct: 671 KARLFAEKINKNERKGKAEITLLVQGQELPEFWEALGGE-PSEIKKHVPEDFWPPQPKLY 729

Query: 616 ECSSHMGCLVLAEVGF-------------------FSQEDLDKYDIMLLDTWQEIFLWLG 656
           +    +G L L ++ +                     Q  LD   + +LD W ++F+WLG
Sbjct: 730 KVGLGLGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILDCWSDVFIWLG 789

Query: 657 EAASEWKEAVA--WGQEYLKTHPAGRSPATPIVLVKQGHEPPTFIGWFFTWDPYKWTSHP 714
             +     A A   GQE        R       L  +G E   F   F  WD      + 
Sbjct: 790 RKSPRLVRAAALKLGQELCGMLHRPRHATVSRSL--EGTEAQVFKAKFKNWDDVLTVDYT 847

Query: 715 SHKEVVDGSPAAASTI-------SEITAEVNNLRLSRWPGNGRAGAVAL 756
            + E V  SP  +  +        ++ A++  L L R P    A A  L
Sbjct: 848 RNAEAVLQSPGLSGKVKRDAEKKDQMKADLTALFLPRQPPMSLAEAEQL 896



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 87/399 (21%), Positives = 154/399 (38%), Gaps = 91/399 (22%)

Query: 4    SKGLPGMQGGLHIWISENRKMVPVPEGAYGNFFEEHCYVIL---HVP------------- 47
            ++ L GM+G    ++ E +K   +PE  +G+F+ + CYV L    VP             
Sbjct: 901  NEDLDGMEG----FVLEGKKFARLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKKEDKE 956

Query: 48   ------QSPKATQGASSD---------LHYWVGKQAGAEA-QGAAEAFQQRLQDELGGQT 91
                  +  +AT  A            +++W G++A          + Q++ +    G+ 
Sbjct: 957  EKAEGKEGEEATAEAEEKQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKL 1016

Query: 92   VLHREAQGHESDCFCSYFRPGIIYRKGGLASDLKHVETNLFNIQRLLHIKGRKHVSA--- 148
             + R  Q  E+  F S+F+   I  +G   +     + +L+ I        R + SA   
Sbjct: 1017 EVVRMTQQQENPKFLSHFKRKFIIHRGKRKAVQGAQQPSLYQI--------RTNGSALCT 1068

Query: 149  --TEVELSWNSFNKGDIFLLDLGKMMIQWNGPKTSISEKARGLALTYSLRDRERGGGRAQ 206
               ++    +  N    F+L   K+  +        SE  +G+   +         GRA 
Sbjct: 1069 RCIQINTDSSLLNSEFCFIL---KVPFE--------SEDNQGIVYAWV--------GRAS 1109

Query: 207  IGVVDDEAK-APDLMQIM-EAVLGRRV------------GSLRAATPSKDINQLQKANVR 252
                 DEAK A D++  M +    ++V              + A  P  D  +  K + R
Sbjct: 1110 ---DPDEAKLAEDILNTMFDTSYSKQVINEGEEPENFFWVGIGAQKPYDDDAEYMK-HTR 1165

Query: 253  LYHVYEKGKDLVVLELATPPLTQDLLQEEDFYILDQGGFKIYVWQGRMSSLQERKAAFSR 312
            L+    +     V E  +    QD L ++D  +LD G  ++Y+W G  +S  E K +   
Sbjct: 1166 LFRCSNEKGYFAVTEKCS-DFCQDDLADDDIMLLDNGQ-EVYMWVGTQTSQVEIKLSLKA 1223

Query: 313  AVGFIQ---AKGYPTYTNVEVVNDGAESAAFKQLFRTWS 348
               +IQ   +K +     + +V  G E  AF + F  WS
Sbjct: 1224 CQVYIQHMRSKEHERPRRLRLVRKGNEQHAFTRCFHAWS 1262


>gi|150417973 supervillin isoform 2 [Homo sapiens]
          Length = 2214

 Score =  162 bits (410), Expect = 1e-39
 Identities = 207/843 (24%), Positives = 314/843 (37%), Gaps = 196/843 (23%)

Query: 137  LLHIKGRKHVSATEVELSWNSFNKGDIFLLDLGKMMIQWNGPKTSISEKARGLALTYSLR 196
            LL IKGR+HV    VE   ++ N GD FLL        W G   ++ EKA+   L   ++
Sbjct: 1445 LLQIKGRRHVQTRLVEPRASALNSGDCFLLLSPHCCFLWVGEFANVIEKAKASELATLIQ 1504

Query: 197  DRERGGGRA------QIGVVDDEAKAPDLMQIMEAVLGRRVGSLRAATPSKDINQLQKAN 250
             +   G RA      + G+      A D  ++    LG +     A  P +D    + A 
Sbjct: 1505 TKRELGCRATYIQTIEEGINTHTHAAKDFWKL----LGGQTSYQSAGDPKED-ELYEAAI 1559

Query: 251  VRLYHVYEKGKDLVVLEL----ATPPLTQDLLQEEDFYILDQGGFKIYVWQGRMSSLQER 306
            +    +Y    D +V +       P  +  LLQ ++  + D G  ++YVW G+  +L +R
Sbjct: 1560 IETNCIYRLMDDKLVPDDDYWGKIPKCS--LLQPKEVLVFDFGS-EVYVWHGKEVTLAQR 1616

Query: 307  KAAFSRAVGFI-------------------------QAKGYPTYTNVEVVNDGAESAAFK 341
            K AF  A                             + +G P +     + +  E+  FK
Sbjct: 1617 KIAFQLAKHLWNGTFDYENCDINPLDPGECNPLIPRKGQGRPDWAIFGRLTEHNETILFK 1676

Query: 342  QLFRTWSEKRRRNQKLGGR------DKSIHVKL-DVGKLHTQPKLAA------------- 381
            + F  W+E +R N+K  G       D    VK  DV ++ + P+  A             
Sbjct: 1677 EKFLDWTELKRSNEKNPGELAQHKEDPRTDVKAYDVTRMVSMPQTTAGTILDGVNVGRGY 1736

Query: 382  ------QLRMVDDGSGKVEVWCIQDLHRQPVDPKRHGQLCAGNCYLVLYTY--------- 426
                    R  +  S  V+VW I +     +  +  GQ   G+ Y+V + +         
Sbjct: 1737 GLVEGHDRRQFEITSVSVDVWHILEFDYSRLPKQSIGQFHEGDAYVVKWKFMVSTAVGSR 1796

Query: 427  -------QRLGRVQYILYLWQGHQATADEIEALNSNAEELDVMYGGVLVQEHVTMGSEPP 479
                   +  G+ + + + WQG  +T  E         ELD   G    Q  V  G EPP
Sbjct: 1797 QKGEHSVRAAGKEKCVYFFWQGRHSTVSEKGTSALMTVELDEERGA---QVQVLQGKEPP 1853

Query: 480  HFLAIFQGQLVIFQERAGHHGKGQSASTTRLFQVQGTDSHNTRTMEVPARASSLNS--SD 537
             FL  FQG +V+   R     +    S  RL+ V+G        +EV    SSL S  S 
Sbjct: 1854 CFLQCFQGGMVVHSGRREEEEENVQ-SEWRLYCVRGEVPVEGNLLEVACHCSSLRSRTSM 1912

Query: 538  IFLLVTASVCYLWFGKGCNGDQREMARVVVTVI-------------SRKNEETVLEGQEP 584
            + L V  ++ YLW G       +E+ R     I             S+       EG EP
Sbjct: 1913 VVLNVNKALIYLWHGCKAQAHTKEVGRTAANKIKEQCPLEAGLHSSSKVTIHECDEGSEP 1972

Query: 585  PHFWEALG--GRAPYPSNKRLPEEVPSFQPRLFECSSHMGCLVLAEVGF----------- 631
              FW+ALG   R  Y    + P    +F PRLF  SS  G     E  +           
Sbjct: 1973 LGFWDALGRRDRKAYDCMLQDPGSF-NFAPRLFILSSSSGDFAATEFVYPARAPSVVSSM 2031

Query: 632  -FSQEDL---DKYDIMLLDTWQEIFLWLG--------------EAASEWKEAVAWGQEYL 673
             F QEDL    +  + L+D   E++LW G                AS+ K A+    +Y 
Sbjct: 2032 PFLQEDLYSAPQPALFLVDNHHEVYLWQGWWPIENKITGSARIRWASDRKSAMETVLQYC 2091

Query: 674  KTHPAGRSPATPIVLVKQGHEPPTFIGWFFTWDPYKWTSHPSHKEVVDGSPAAASTISEI 733
            K     + PA    L+  G EP TF   F +W+         H+E +       + I+E+
Sbjct: 2092 KGKNL-KKPAPKSYLIHAGLEPLTFTNMFPSWE---------HREDI-------AEITEM 2134

Query: 734  TAEVNNLRLSRWPGNGRAGAVALQALKGSQDSSENDLVRSPKSAGSRTSSSVSSTSATIN 793
              EV+N                           +  LV    +   +T   ++   A   
Sbjct: 2135 DTEVSN---------------------------QITLVEDVLAKLCKTIYPLADLLA--- 2164

Query: 794  GGLRREQLMHQAVEDLPEGVDPARREFYLSDSDFQDIFGKSKEEFYSMATWRQRQEKKQL 853
                           LPEGVDP + E YL+D DF+     +++E+ ++  W+Q   KK  
Sbjct: 2165 -------------RPLPEGVDPLKLEIYLTDEDFEFALDMTRDEYNALPAWKQVNLKKAK 2211

Query: 854  GFF 856
            G F
Sbjct: 2212 GLF 2214



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 68/299 (22%), Positives = 123/299 (41%), Gaps = 58/299 (19%)

Query: 402  HRQPVDPKRHGQ--------LCAGNCYLVLYTYQRLGRVQYILYLWQGHQATADEIEALN 453
            H++ V PKR  Q        L A    L  YT QRL     + ++    ++   ++E ++
Sbjct: 1348 HKRAVRPKRRVQASKNPLKMLAAREDLLQEYTEQRLN----VAFM----ESKRMKVEKMS 1399

Query: 454  SNAEELDVMYGGVLVQEHVTMGSEPPHFLAIFQGQLVIFQERAGHHGKGQSASTTRLFQV 513
            SN+   +V   G+  +E+             F    +        +    +    RL  +
Sbjct: 1400 SNSNFSEVTLAGLASKEN-------------FSNVSLRSVNLTEQNSNNSAVPYKRLMLL 1446

Query: 514  QGTDSHNTRTMEVPARASSLNSSDIFLLVTASVCYLWFGKGCNGDQREMARVVVTVISRK 573
            Q     + +T  V  RAS+LNS D FLL++   C+LW G+  N  ++  A  + T+I  K
Sbjct: 1447 QIKGRRHVQTRLVEPRASALNSGDCFLLLSPHCCFLWVGEFANVIEKAKASELATLIQTK 1506

Query: 574  NE--------ETVLEG-----QEPPHFWEALGGRAPYPSNKRLPEEVPSFQPRLFECSSH 620
             E        +T+ EG          FW+ LGG+  Y S    P+E   ++  + E +  
Sbjct: 1507 RELGCRATYIQTIEEGINTHTHAAKDFWKLLGGQTSYQSAGD-PKEDELYEAAIIETN-- 1563

Query: 621  MGCLV-LAEVGFFSQED----------LDKYDIMLLDTWQEIFLWLGEAASEWKEAVAW 668
              C+  L +      +D          L   ++++ D   E+++W G+  +  +  +A+
Sbjct: 1564 --CIYRLMDDKLVPDDDYWGKIPKCSLLQPKEVLVFDFGSEVYVWHGKEVTLAQRKIAF 1620



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 70/369 (18%), Positives = 133/369 (36%), Gaps = 55/369 (14%)

Query: 27   VPEGAYGNFFEEHCYVILHVPQSPKATQGASSDLH-------------YWVGKQAGAEAQ 73
            +P+ + G F E   YV+        A        H             +W G+ +    +
Sbjct: 1767 LPKQSIGQFHEGDAYVVKWKFMVSTAVGSRQKGEHSVRAAGKEKCVYFFWQGRHSTVSEK 1826

Query: 74   GAAEAFQQRLQDELGGQTVLHREAQGHESDCFCSYFRPGIIYRKGGLASDLKHVETNLFN 133
            G +      L +E G Q    +  QG E  CF   F+ G++   G    +    E N+ +
Sbjct: 1827 GTSALMTVELDEERGAQV---QVLQGKEPPCFLQCFQGGMVVHSGRREEE----EENVQS 1879

Query: 134  IQRLLHIKGRKHVSATEVELSWNSF---NKGDIFLLDLGKMMIQ-WNGPKTSISEKARGL 189
              RL  ++G   V    +E++ +     ++  + +L++ K +I  W+G K     K  G 
Sbjct: 1880 EWRLYCVRGEVPVEGNLLEVACHCSSLRSRTSMVVLNVNKALIYLWHGCKAQAHTKEVGR 1939

Query: 190  ALTYSLRDR---ERGGGRAQIGVVDDEAKAPDLMQIMEAVLGRRVGSLRAATPSKDINQL 246
                 ++++   E G   +    + +  +  + +   +A LGRR          +D    
Sbjct: 1940 TAANKIKEQCPLEAGLHSSSKVTIHECDEGSEPLGFWDA-LGRRDRKAYDCM-LQDPGSF 1997

Query: 247  QKANVRLYHVYEKGKDLVVLELATPPLTQDLLQ-----EEDFYILDQGGF-------KIY 294
              A  RL+ +     D    E   P     ++      +ED Y   Q          ++Y
Sbjct: 1998 NFA-PRLFILSSSSGDFAATEFVYPARAPSVVSSMPFLQEDLYSAPQPALFLVDNHHEVY 2056

Query: 295  VWQG------------RMSSLQERKAAFSRAVGFIQAKGY-PTYTNVEVVNDGAESAAFK 341
            +WQG            R+    +RK+A    + + + K          +++ G E   F 
Sbjct: 2057 LWQGWWPIENKITGSARIRWASDRKSAMETVLQYCKGKNLKKPAPKSYLIHAGLEPLTFT 2116

Query: 342  QLFRTWSEK 350
             +F +W  +
Sbjct: 2117 NMFPSWEHR 2125


>gi|150417971 supervillin isoform 1 [Homo sapiens]
          Length = 1788

 Score =  162 bits (410), Expect = 1e-39
 Identities = 207/843 (24%), Positives = 314/843 (37%), Gaps = 196/843 (23%)

Query: 137  LLHIKGRKHVSATEVELSWNSFNKGDIFLLDLGKMMIQWNGPKTSISEKARGLALTYSLR 196
            LL IKGR+HV    VE   ++ N GD FLL        W G   ++ EKA+   L   ++
Sbjct: 1019 LLQIKGRRHVQTRLVEPRASALNSGDCFLLLSPHCCFLWVGEFANVIEKAKASELATLIQ 1078

Query: 197  DRERGGGRA------QIGVVDDEAKAPDLMQIMEAVLGRRVGSLRAATPSKDINQLQKAN 250
             +   G RA      + G+      A D  ++    LG +     A  P +D    + A 
Sbjct: 1079 TKRELGCRATYIQTIEEGINTHTHAAKDFWKL----LGGQTSYQSAGDPKED-ELYEAAI 1133

Query: 251  VRLYHVYEKGKDLVVLEL----ATPPLTQDLLQEEDFYILDQGGFKIYVWQGRMSSLQER 306
            +    +Y    D +V +       P  +  LLQ ++  + D G  ++YVW G+  +L +R
Sbjct: 1134 IETNCIYRLMDDKLVPDDDYWGKIPKCS--LLQPKEVLVFDFGS-EVYVWHGKEVTLAQR 1190

Query: 307  KAAFSRAVGFI-------------------------QAKGYPTYTNVEVVNDGAESAAFK 341
            K AF  A                             + +G P +     + +  E+  FK
Sbjct: 1191 KIAFQLAKHLWNGTFDYENCDINPLDPGECNPLIPRKGQGRPDWAIFGRLTEHNETILFK 1250

Query: 342  QLFRTWSEKRRRNQKLGGR------DKSIHVKL-DVGKLHTQPKLAA------------- 381
            + F  W+E +R N+K  G       D    VK  DV ++ + P+  A             
Sbjct: 1251 EKFLDWTELKRSNEKNPGELAQHKEDPRTDVKAYDVTRMVSMPQTTAGTILDGVNVGRGY 1310

Query: 382  ------QLRMVDDGSGKVEVWCIQDLHRQPVDPKRHGQLCAGNCYLVLYTY--------- 426
                    R  +  S  V+VW I +     +  +  GQ   G+ Y+V + +         
Sbjct: 1311 GLVEGHDRRQFEITSVSVDVWHILEFDYSRLPKQSIGQFHEGDAYVVKWKFMVSTAVGSR 1370

Query: 427  -------QRLGRVQYILYLWQGHQATADEIEALNSNAEELDVMYGGVLVQEHVTMGSEPP 479
                   +  G+ + + + WQG  +T  E         ELD   G    Q  V  G EPP
Sbjct: 1371 QKGEHSVRAAGKEKCVYFFWQGRHSTVSEKGTSALMTVELDEERGA---QVQVLQGKEPP 1427

Query: 480  HFLAIFQGQLVIFQERAGHHGKGQSASTTRLFQVQGTDSHNTRTMEVPARASSLNS--SD 537
             FL  FQG +V+   R     +    S  RL+ V+G        +EV    SSL S  S 
Sbjct: 1428 CFLQCFQGGMVVHSGRREEEEENVQ-SEWRLYCVRGEVPVEGNLLEVACHCSSLRSRTSM 1486

Query: 538  IFLLVTASVCYLWFGKGCNGDQREMARVVVTVI-------------SRKNEETVLEGQEP 584
            + L V  ++ YLW G       +E+ R     I             S+       EG EP
Sbjct: 1487 VVLNVNKALIYLWHGCKAQAHTKEVGRTAANKIKEQCPLEAGLHSSSKVTIHECDEGSEP 1546

Query: 585  PHFWEALG--GRAPYPSNKRLPEEVPSFQPRLFECSSHMGCLVLAEVGF----------- 631
              FW+ALG   R  Y    + P    +F PRLF  SS  G     E  +           
Sbjct: 1547 LGFWDALGRRDRKAYDCMLQDPGSF-NFAPRLFILSSSSGDFAATEFVYPARAPSVVSSM 1605

Query: 632  -FSQEDL---DKYDIMLLDTWQEIFLWLG--------------EAASEWKEAVAWGQEYL 673
             F QEDL    +  + L+D   E++LW G                AS+ K A+    +Y 
Sbjct: 1606 PFLQEDLYSAPQPALFLVDNHHEVYLWQGWWPIENKITGSARIRWASDRKSAMETVLQYC 1665

Query: 674  KTHPAGRSPATPIVLVKQGHEPPTFIGWFFTWDPYKWTSHPSHKEVVDGSPAAASTISEI 733
            K     + PA    L+  G EP TF   F +W+         H+E +       + I+E+
Sbjct: 1666 KGKNL-KKPAPKSYLIHAGLEPLTFTNMFPSWE---------HREDI-------AEITEM 1708

Query: 734  TAEVNNLRLSRWPGNGRAGAVALQALKGSQDSSENDLVRSPKSAGSRTSSSVSSTSATIN 793
              EV+N                           +  LV    +   +T   ++   A   
Sbjct: 1709 DTEVSN---------------------------QITLVEDVLAKLCKTIYPLADLLA--- 1738

Query: 794  GGLRREQLMHQAVEDLPEGVDPARREFYLSDSDFQDIFGKSKEEFYSMATWRQRQEKKQL 853
                           LPEGVDP + E YL+D DF+     +++E+ ++  W+Q   KK  
Sbjct: 1739 -------------RPLPEGVDPLKLEIYLTDEDFEFALDMTRDEYNALPAWKQVNLKKAK 1785

Query: 854  GFF 856
            G F
Sbjct: 1786 GLF 1788



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 68/299 (22%), Positives = 123/299 (41%), Gaps = 58/299 (19%)

Query: 402  HRQPVDPKRHGQ--------LCAGNCYLVLYTYQRLGRVQYILYLWQGHQATADEIEALN 453
            H++ V PKR  Q        L A    L  YT QRL     + ++    ++   ++E ++
Sbjct: 922  HKRAVRPKRRVQASKNPLKMLAAREDLLQEYTEQRLN----VAFM----ESKRMKVEKMS 973

Query: 454  SNAEELDVMYGGVLVQEHVTMGSEPPHFLAIFQGQLVIFQERAGHHGKGQSASTTRLFQV 513
            SN+   +V   G+  +E+             F    +        +    +    RL  +
Sbjct: 974  SNSNFSEVTLAGLASKEN-------------FSNVSLRSVNLTEQNSNNSAVPYKRLMLL 1020

Query: 514  QGTDSHNTRTMEVPARASSLNSSDIFLLVTASVCYLWFGKGCNGDQREMARVVVTVISRK 573
            Q     + +T  V  RAS+LNS D FLL++   C+LW G+  N  ++  A  + T+I  K
Sbjct: 1021 QIKGRRHVQTRLVEPRASALNSGDCFLLLSPHCCFLWVGEFANVIEKAKASELATLIQTK 1080

Query: 574  NE--------ETVLEG-----QEPPHFWEALGGRAPYPSNKRLPEEVPSFQPRLFECSSH 620
             E        +T+ EG          FW+ LGG+  Y S    P+E   ++  + E +  
Sbjct: 1081 RELGCRATYIQTIEEGINTHTHAAKDFWKLLGGQTSYQSAGD-PKEDELYEAAIIETN-- 1137

Query: 621  MGCLV-LAEVGFFSQED----------LDKYDIMLLDTWQEIFLWLGEAASEWKEAVAW 668
              C+  L +      +D          L   ++++ D   E+++W G+  +  +  +A+
Sbjct: 1138 --CIYRLMDDKLVPDDDYWGKIPKCSLLQPKEVLVFDFGSEVYVWHGKEVTLAQRKIAF 1194



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 70/369 (18%), Positives = 133/369 (36%), Gaps = 55/369 (14%)

Query: 27   VPEGAYGNFFEEHCYVILHVPQSPKATQGASSDLH-------------YWVGKQAGAEAQ 73
            +P+ + G F E   YV+        A        H             +W G+ +    +
Sbjct: 1341 LPKQSIGQFHEGDAYVVKWKFMVSTAVGSRQKGEHSVRAAGKEKCVYFFWQGRHSTVSEK 1400

Query: 74   GAAEAFQQRLQDELGGQTVLHREAQGHESDCFCSYFRPGIIYRKGGLASDLKHVETNLFN 133
            G +      L +E G Q    +  QG E  CF   F+ G++   G    +    E N+ +
Sbjct: 1401 GTSALMTVELDEERGAQV---QVLQGKEPPCFLQCFQGGMVVHSGRREEE----EENVQS 1453

Query: 134  IQRLLHIKGRKHVSATEVELSWNSF---NKGDIFLLDLGKMMIQ-WNGPKTSISEKARGL 189
              RL  ++G   V    +E++ +     ++  + +L++ K +I  W+G K     K  G 
Sbjct: 1454 EWRLYCVRGEVPVEGNLLEVACHCSSLRSRTSMVVLNVNKALIYLWHGCKAQAHTKEVGR 1513

Query: 190  ALTYSLRDR---ERGGGRAQIGVVDDEAKAPDLMQIMEAVLGRRVGSLRAATPSKDINQL 246
                 ++++   E G   +    + +  +  + +   +A LGRR          +D    
Sbjct: 1514 TAANKIKEQCPLEAGLHSSSKVTIHECDEGSEPLGFWDA-LGRRDRKAYDCM-LQDPGSF 1571

Query: 247  QKANVRLYHVYEKGKDLVVLELATPPLTQDLLQ-----EEDFYILDQGGF-------KIY 294
              A  RL+ +     D    E   P     ++      +ED Y   Q          ++Y
Sbjct: 1572 NFA-PRLFILSSSSGDFAATEFVYPARAPSVVSSMPFLQEDLYSAPQPALFLVDNHHEVY 1630

Query: 295  VWQG------------RMSSLQERKAAFSRAVGFIQAKGY-PTYTNVEVVNDGAESAAFK 341
            +WQG            R+    +RK+A    + + + K          +++ G E   F 
Sbjct: 1631 LWQGWWPIENKITGSARIRWASDRKSAMETVLQYCKGKNLKKPAPKSYLIHAGLEPLTFT 1690

Query: 342  QLFRTWSEK 350
             +F +W  +
Sbjct: 1691 NMFPSWEHR 1699


>gi|166706877 erythrocyte membrane protein band 4.9 isoform 1 [Homo
           sapiens]
          Length = 405

 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 21/48 (43%), Positives = 28/48 (58%)

Query: 809 LPEGVDPARREFYLSDSDFQDIFGKSKEEFYSMATWRQRQEKKQLGFF 856
           LP GVD  R E +LS  DF  +F  S EEF  +A W++ + KK+   F
Sbjct: 358 LPPGVDRMRLERHLSAEDFSRVFAMSPEEFGKLALWKRNELKKKASLF 405


>gi|166706885 erythrocyte membrane protein band 4.9 isoform 3 [Homo
           sapiens]
          Length = 358

 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 21/48 (43%), Positives = 28/48 (58%)

Query: 809 LPEGVDPARREFYLSDSDFQDIFGKSKEEFYSMATWRQRQEKKQLGFF 856
           LP GVD  R E +LS  DF  +F  S EEF  +A W++ + KK+   F
Sbjct: 311 LPPGVDRMRLERHLSAEDFSRVFAMSPEEFGKLALWKRNELKKKASLF 358


>gi|166706883 erythrocyte membrane protein band 4.9 isoform 2 [Homo
           sapiens]
          Length = 383

 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 21/48 (43%), Positives = 28/48 (58%)

Query: 809 LPEGVDPARREFYLSDSDFQDIFGKSKEEFYSMATWRQRQEKKQLGFF 856
           LP GVD  R E +LS  DF  +F  S EEF  +A W++ + KK+   F
Sbjct: 336 LPPGVDRMRLERHLSAEDFSRVFAMSPEEFGKLALWKRNELKKKASLF 383


>gi|166706881 erythrocyte membrane protein band 4.9 isoform 2 [Homo
           sapiens]
          Length = 383

 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 21/48 (43%), Positives = 28/48 (58%)

Query: 809 LPEGVDPARREFYLSDSDFQDIFGKSKEEFYSMATWRQRQEKKQLGFF 856
           LP GVD  R E +LS  DF  +F  S EEF  +A W++ + KK+   F
Sbjct: 336 LPPGVDRMRLERHLSAEDFSRVFAMSPEEFGKLALWKRNELKKKASLF 383


>gi|166706879 erythrocyte membrane protein band 4.9 isoform 1 [Homo
           sapiens]
          Length = 405

 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 21/48 (43%), Positives = 28/48 (58%)

Query: 809 LPEGVDPARREFYLSDSDFQDIFGKSKEEFYSMATWRQRQEKKQLGFF 856
           LP GVD  R E +LS  DF  +F  S EEF  +A W++ + KK+   F
Sbjct: 358 LPPGVDRMRLERHLSAEDFSRVFAMSPEEFGKLALWKRNELKKKASLF 405


>gi|166706875 erythrocyte membrane protein band 4.9 isoform 1 [Homo
           sapiens]
          Length = 405

 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 21/48 (43%), Positives = 28/48 (58%)

Query: 809 LPEGVDPARREFYLSDSDFQDIFGKSKEEFYSMATWRQRQEKKQLGFF 856
           LP GVD  R E +LS  DF  +F  S EEF  +A W++ + KK+   F
Sbjct: 358 LPPGVDRMRLERHLSAEDFSRVFAMSPEEFGKLALWKRNELKKKASLF 405


>gi|153792514 actin binding LIM protein family, member 2 isoform 6
           [Homo sapiens]
          Length = 521

 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 21/48 (43%), Positives = 30/48 (62%)

Query: 809 LPEGVDPARREFYLSDSDFQDIFGKSKEEFYSMATWRQRQEKKQLGFF 856
           LP+ VD  R E +LS  +FQ++FG S EEF  +A W++   KK+   F
Sbjct: 474 LPKDVDRTRLERHLSPEEFQEVFGMSIEEFDRLALWKRNDLKKKALLF 521


>gi|194272204 actin binding LIM protein family, member 2 isoform 5
           [Homo sapiens]
          Length = 531

 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 21/48 (43%), Positives = 30/48 (62%)

Query: 809 LPEGVDPARREFYLSDSDFQDIFGKSKEEFYSMATWRQRQEKKQLGFF 856
           LP+ VD  R E +LS  +FQ++FG S EEF  +A W++   KK+   F
Sbjct: 484 LPKDVDRTRLERHLSPEEFQEVFGMSIEEFDRLALWKRNDLKKKALLF 531


>gi|194272202 actin binding LIM protein family, member 2 isoform 4
           [Homo sapiens]
          Length = 559

 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 21/48 (43%), Positives = 30/48 (62%)

Query: 809 LPEGVDPARREFYLSDSDFQDIFGKSKEEFYSMATWRQRQEKKQLGFF 856
           LP+ VD  R E +LS  +FQ++FG S EEF  +A W++   KK+   F
Sbjct: 512 LPKDVDRTRLERHLSPEEFQEVFGMSIEEFDRLALWKRNDLKKKALLF 559


>gi|194272200 actin binding LIM protein family, member 2 isoform 3
           [Homo sapiens]
          Length = 572

 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 21/48 (43%), Positives = 30/48 (62%)

Query: 809 LPEGVDPARREFYLSDSDFQDIFGKSKEEFYSMATWRQRQEKKQLGFF 856
           LP+ VD  R E +LS  +FQ++FG S EEF  +A W++   KK+   F
Sbjct: 525 LPKDVDRTRLERHLSPEEFQEVFGMSIEEFDRLALWKRNDLKKKALLF 572


>gi|194272198 actin binding LIM protein family, member 2 isoform 2
           [Homo sapiens]
          Length = 611

 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 21/48 (43%), Positives = 30/48 (62%)

Query: 809 LPEGVDPARREFYLSDSDFQDIFGKSKEEFYSMATWRQRQEKKQLGFF 856
           LP+ VD  R E +LS  +FQ++FG S EEF  +A W++   KK+   F
Sbjct: 564 LPKDVDRTRLERHLSPEEFQEVFGMSIEEFDRLALWKRNDLKKKALLF 611


>gi|194272196 actin binding LIM protein family, member 2 isoform 1
           [Homo sapiens]
          Length = 645

 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 21/48 (43%), Positives = 30/48 (62%)

Query: 809 LPEGVDPARREFYLSDSDFQDIFGKSKEEFYSMATWRQRQEKKQLGFF 856
           LP+ VD  R E +LS  +FQ++FG S EEF  +A W++   KK+   F
Sbjct: 598 LPKDVDRTRLERHLSPEEFQEVFGMSIEEFDRLALWKRNDLKKKALLF 645


>gi|7662330 actin binding LIM protein family, member 3 [Homo
           sapiens]
          Length = 683

 Score = 41.6 bits (96), Expect = 0.003
 Identities = 19/48 (39%), Positives = 28/48 (58%)

Query: 809 LPEGVDPARREFYLSDSDFQDIFGKSKEEFYSMATWRQRQEKKQLGFF 856
           LP+ VD  R E +LS  +F  +FG +  EF  +A W++ + KKQ   F
Sbjct: 636 LPKDVDRTRLERHLSQEEFYQVFGMTISEFDRLALWKRNELKKQARLF 683


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.134    0.407 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,974,718
Number of Sequences: 37866
Number of extensions: 1574032
Number of successful extensions: 4029
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 38
Number of HSP's successfully gapped in prelim test: 21
Number of HSP's that attempted gapping in prelim test: 3671
Number of HSP's gapped (non-prelim): 99
length of query: 856
length of database: 18,247,518
effective HSP length: 111
effective length of query: 745
effective length of database: 14,044,392
effective search space: 10463072040
effective search space used: 10463072040
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.