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Search of human proteins with 94557295
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|94557295 mitogen-activated protein kinase 8 interacting
protein 3 isoform 2 [Homo sapiens]
(1330 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|94557295 mitogen-activated protein kinase 8 interacting prote... 2679 0.0
gi|94557297 mitogen-activated protein kinase 8 interacting prote... 2673 0.0
gi|27436920 sperm associated antigen 9 isoform 3 [Homo sapiens] 1389 0.0
gi|194578923 sperm associated antigen 9 isoform 1 [Homo sapiens] 1387 0.0
gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17 [Hom... 144 6e-34
gi|58761492 Rho guanine nucleotide exchange factor (GEF) 10-like... 112 2e-24
gi|74136547 Rho guanine nucleotide exchange factor (GEF) 10-like... 112 2e-24
gi|62548864 Rho guanine nucleotide exchange factor 10 [Homo sapi... 102 2e-21
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 59 3e-08
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 59 3e-08
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 59 3e-08
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 59 3e-08
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 59 3e-08
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 54 1e-06
gi|56961680 coiled-coil domain containing 147 [Homo sapiens] 54 1e-06
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 53 2e-06
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 53 2e-06
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 52 3e-06
gi|115648142 centrosomal protein 164kDa [Homo sapiens] 51 6e-06
gi|93204881 Rab interacting lysosomal protein [Homo sapiens] 50 1e-05
gi|4502443 dystonin isoform 1e precursor [Homo sapiens] 50 1e-05
gi|195947382 Rab interacting lysosomal protein-like 1 [Homo sapi... 49 2e-05
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 49 3e-05
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 49 3e-05
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 49 3e-05
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 49 3e-05
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 48 7e-05
gi|215982794 myosin VA isoform 2 [Homo sapiens] 47 9e-05
gi|215982791 myosin VA isoform 1 [Homo sapiens] 47 9e-05
gi|55770834 centromere protein F [Homo sapiens] 47 9e-05
>gi|94557295 mitogen-activated protein kinase 8 interacting protein 3
isoform 2 [Homo sapiens]
Length = 1330
Score = 2679 bits (6945), Expect = 0.0
Identities = 1330/1330 (100%), Positives = 1330/1330 (100%)
Query: 1 MMEIQMDEGGGVVVYQDDYCSGSVMSERVSGLAGSIYREFERLIHCYDEEVVKELMPLVV 60
MMEIQMDEGGGVVVYQDDYCSGSVMSERVSGLAGSIYREFERLIHCYDEEVVKELMPLVV
Sbjct: 1 MMEIQMDEGGGVVVYQDDYCSGSVMSERVSGLAGSIYREFERLIHCYDEEVVKELMPLVV 60
Query: 61 NVLENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKK 120
NVLENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKK
Sbjct: 61 NVLENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKK 120
Query: 121 ELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIE 180
ELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIE
Sbjct: 121 ELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIE 180
Query: 181 RSKMQQVGGNSQTESSLPGRRKERPTSLNVFPLADGTVRAQIGGKLVPAGDHWHLSDLGQ 240
RSKMQQVGGNSQTESSLPGRRKERPTSLNVFPLADGTVRAQIGGKLVPAGDHWHLSDLGQ
Sbjct: 181 RSKMQQVGGNSQTESSLPGRRKERPTSLNVFPLADGTVRAQIGGKLVPAGDHWHLSDLGQ 240
Query: 241 LQSSSSYQCPQDEMSESGQSSAAATPSTTGTKSNTPTSSVPSAAVTPLNESLQPLGDYGV 300
LQSSSSYQCPQDEMSESGQSSAAATPSTTGTKSNTPTSSVPSAAVTPLNESLQPLGDYGV
Sbjct: 241 LQSSSSYQCPQDEMSESGQSSAAATPSTTGTKSNTPTSSVPSAAVTPLNESLQPLGDYGV 300
Query: 301 GSKNSKRAREKRDSRNMEVQVTQEMRNVSIGMGSSDEWSDVQDIIDSTPELDMCPETRLD 360
GSKNSKRAREKRDSRNMEVQVTQEMRNVSIGMGSSDEWSDVQDIIDSTPELDMCPETRLD
Sbjct: 301 GSKNSKRAREKRDSRNMEVQVTQEMRNVSIGMGSSDEWSDVQDIIDSTPELDMCPETRLD 360
Query: 361 RTGSSPTQGIVNKAFGINTDSLYHELSTAGSEVIGDVDEGADLLGEFSGMGKEVGNLLLE 420
RTGSSPTQGIVNKAFGINTDSLYHELSTAGSEVIGDVDEGADLLGEFSGMGKEVGNLLLE
Sbjct: 361 RTGSSPTQGIVNKAFGINTDSLYHELSTAGSEVIGDVDEGADLLGEFSGMGKEVGNLLLE 420
Query: 421 NSQLLETKNALNVVKNDLIAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELEEELKRV 480
NSQLLETKNALNVVKNDLIAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELEEELKRV
Sbjct: 421 NSQLLETKNALNVVKNDLIAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELEEELKRV 480
Query: 481 KSEAIIARREPKEEAEDVSSYLCTESDKIPMAQRRRFTRVEMARVLMERNQYKERLMELQ 540
KSEAIIARREPKEEAEDVSSYLCTESDKIPMAQRRRFTRVEMARVLMERNQYKERLMELQ
Sbjct: 481 KSEAIIARREPKEEAEDVSSYLCTESDKIPMAQRRRFTRVEMARVLMERNQYKERLMELQ 540
Query: 541 EAVRWTEMIRASREHPSVQEKKKSTIWQFFSRLFSSSSSPPPAKRPYPSVNIHYKSPTTA 600
EAVRWTEMIRASREHPSVQEKKKSTIWQFFSRLFSSSSSPPPAKRPYPSVNIHYKSPTTA
Sbjct: 541 EAVRWTEMIRASREHPSVQEKKKSTIWQFFSRLFSSSSSPPPAKRPYPSVNIHYKSPTTA 600
Query: 601 GFSQRRNHAMCPISAGSRPLEFFPDDDCTSSARREQKREQYRQVREHVRNDDGRLQACGW 660
GFSQRRNHAMCPISAGSRPLEFFPDDDCTSSARREQKREQYRQVREHVRNDDGRLQACGW
Sbjct: 601 GFSQRRNHAMCPISAGSRPLEFFPDDDCTSSARREQKREQYRQVREHVRNDDGRLQACGW 660
Query: 661 SLPAKYKQLSPNGGQEDTRMKNVPVPVYCRPLVEKDPTMKLWCAAGVNLSGWRPNEDDAG 720
SLPAKYKQLSPNGGQEDTRMKNVPVPVYCRPLVEKDPTMKLWCAAGVNLSGWRPNEDDAG
Sbjct: 661 SLPAKYKQLSPNGGQEDTRMKNVPVPVYCRPLVEKDPTMKLWCAAGVNLSGWRPNEDDAG 720
Query: 721 NGVKPAPGRDPLTCDREGDGEPKSAHTSPEKKKAKELPEMDATSSRVWILTSTLTTSKVV 780
NGVKPAPGRDPLTCDREGDGEPKSAHTSPEKKKAKELPEMDATSSRVWILTSTLTTSKVV
Sbjct: 721 NGVKPAPGRDPLTCDREGDGEPKSAHTSPEKKKAKELPEMDATSSRVWILTSTLTTSKVV 780
Query: 781 IIDANQPGTVVDQFTVCNAHVLCISSIPAASDSDYPPGEMFLDSDVNPEDPGADGVLAGI 840
IIDANQPGTVVDQFTVCNAHVLCISSIPAASDSDYPPGEMFLDSDVNPEDPGADGVLAGI
Sbjct: 781 IIDANQPGTVVDQFTVCNAHVLCISSIPAASDSDYPPGEMFLDSDVNPEDPGADGVLAGI 840
Query: 841 TLVGCATRCNVPRSNCSSRGDTPVLDKGQGEVATIANGKVNPSQSTEEATEATEVPDPGP 900
TLVGCATRCNVPRSNCSSRGDTPVLDKGQGEVATIANGKVNPSQSTEEATEATEVPDPGP
Sbjct: 841 TLVGCATRCNVPRSNCSSRGDTPVLDKGQGEVATIANGKVNPSQSTEEATEATEVPDPGP 900
Query: 901 SEPETATLRPGPLTEHVFTDPAPTPSSGPQPGSENGPEPDSSSTRPEPEPSGDPTGAGSS 960
SEPETATLRPGPLTEHVFTDPAPTPSSGPQPGSENGPEPDSSSTRPEPEPSGDPTGAGSS
Sbjct: 901 SEPETATLRPGPLTEHVFTDPAPTPSSGPQPGSENGPEPDSSSTRPEPEPSGDPTGAGSS 960
Query: 961 AAPTMWLGAQNGWLYVHSAVANWKKCLHSIKLKDSVLSLVHVKGRVLVALADGTLAIFHR 1020
AAPTMWLGAQNGWLYVHSAVANWKKCLHSIKLKDSVLSLVHVKGRVLVALADGTLAIFHR
Sbjct: 961 AAPTMWLGAQNGWLYVHSAVANWKKCLHSIKLKDSVLSLVHVKGRVLVALADGTLAIFHR 1020
Query: 1021 GEDGQWDLSNYHLMDLGHPHHSIRCMAVVYDRVWCGYKNKVHVIQPKTMQIEKSFDAHPR 1080
GEDGQWDLSNYHLMDLGHPHHSIRCMAVVYDRVWCGYKNKVHVIQPKTMQIEKSFDAHPR
Sbjct: 1021 GEDGQWDLSNYHLMDLGHPHHSIRCMAVVYDRVWCGYKNKVHVIQPKTMQIEKSFDAHPR 1080
Query: 1081 RESQVRQLAWIGDGVWVSIRLDSTLRLYHAHTHQHLQDVDIEPYVSKMLGTGKLGFSFVR 1140
RESQVRQLAWIGDGVWVSIRLDSTLRLYHAHTHQHLQDVDIEPYVSKMLGTGKLGFSFVR
Sbjct: 1081 RESQVRQLAWIGDGVWVSIRLDSTLRLYHAHTHQHLQDVDIEPYVSKMLGTGKLGFSFVR 1140
Query: 1141 ITALLVAGSRLWVGTGNGVVISIPLTETVVLHRGQLLGLRANKTSPTSGEGARPGGIIHV 1200
ITALLVAGSRLWVGTGNGVVISIPLTETVVLHRGQLLGLRANKTSPTSGEGARPGGIIHV
Sbjct: 1141 ITALLVAGSRLWVGTGNGVVISIPLTETVVLHRGQLLGLRANKTSPTSGEGARPGGIIHV 1200
Query: 1201 YGDDSSDRAASSFIPYCSMAQAQLCFHGHRDAVKFFVSVPGNVLATLNGSVLDSPAEGPG 1260
YGDDSSDRAASSFIPYCSMAQAQLCFHGHRDAVKFFVSVPGNVLATLNGSVLDSPAEGPG
Sbjct: 1201 YGDDSSDRAASSFIPYCSMAQAQLCFHGHRDAVKFFVSVPGNVLATLNGSVLDSPAEGPG 1260
Query: 1261 PAAPASEVEGQKLRNVLVLSGGEGYIDFRIGDGEDDETEEGAGDMSQVKPVLSKAERSHI 1320
PAAPASEVEGQKLRNVLVLSGGEGYIDFRIGDGEDDETEEGAGDMSQVKPVLSKAERSHI
Sbjct: 1261 PAAPASEVEGQKLRNVLVLSGGEGYIDFRIGDGEDDETEEGAGDMSQVKPVLSKAERSHI 1320
Query: 1321 IVWQVSYTPE 1330
IVWQVSYTPE
Sbjct: 1321 IVWQVSYTPE 1330
>gi|94557297 mitogen-activated protein kinase 8 interacting protein 3
isoform 1 [Homo sapiens]
Length = 1336
Score = 2673 bits (6928), Expect = 0.0
Identities = 1330/1336 (99%), Positives = 1330/1336 (99%), Gaps = 6/1336 (0%)
Query: 1 MMEIQMDEGGGVVVYQDDYCSGSVMSERVSGLAGSIYREFERLIHCYDEEVVKELMPLVV 60
MMEIQMDEGGGVVVYQDDYCSGSVMSERVSGLAGSIYREFERLIHCYDEEVVKELMPLVV
Sbjct: 1 MMEIQMDEGGGVVVYQDDYCSGSVMSERVSGLAGSIYREFERLIHCYDEEVVKELMPLVV 60
Query: 61 NVLENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKK 120
NVLENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKK
Sbjct: 61 NVLENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKK 120
Query: 121 ELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIE 180
ELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIE
Sbjct: 121 ELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIE 180
Query: 181 RSKMQQVGGNSQTESSLPGRRKERPTSLNVFPLADGTVRAQIGGKLVPAGDHWHLSDLGQ 240
RSKMQQVGGNSQTESSLPGRRKERPTSLNVFPLADGTVRAQIGGKLVPAGDHWHLSDLGQ
Sbjct: 181 RSKMQQVGGNSQTESSLPGRRKERPTSLNVFPLADGTVRAQIGGKLVPAGDHWHLSDLGQ 240
Query: 241 LQSSSSYQCPQDEMSESGQSSAAATPSTTGTKSNTPTSSVPSAAVTPLNESLQPLGDYGV 300
LQSSSSYQCPQDEMSESGQSSAAATPSTTGTKSNTPTSSVPSAAVTPLNESLQPLGDYGV
Sbjct: 241 LQSSSSYQCPQDEMSESGQSSAAATPSTTGTKSNTPTSSVPSAAVTPLNESLQPLGDYGV 300
Query: 301 GSKNSKRAREKRDSRNMEVQVTQEMRNVSIGMGSSDEWSDVQDIIDSTPELDMCPETRLD 360
GSKNSKRAREKRDSRNMEVQVTQEMRNVSIGMGSSDEWSDVQDIIDSTPELDMCPETRLD
Sbjct: 301 GSKNSKRAREKRDSRNMEVQVTQEMRNVSIGMGSSDEWSDVQDIIDSTPELDMCPETRLD 360
Query: 361 RTGSSPTQGIVNKAFGINTDSLYHELSTAGSEVIGDVDEGADLLGEFS------GMGKEV 414
RTGSSPTQGIVNKAFGINTDSLYHELSTAGSEVIGDVDEGADLLGEFS GMGKEV
Sbjct: 361 RTGSSPTQGIVNKAFGINTDSLYHELSTAGSEVIGDVDEGADLLGEFSVRDDFFGMGKEV 420
Query: 415 GNLLLENSQLLETKNALNVVKNDLIAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELE 474
GNLLLENSQLLETKNALNVVKNDLIAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELE
Sbjct: 421 GNLLLENSQLLETKNALNVVKNDLIAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELE 480
Query: 475 EELKRVKSEAIIARREPKEEAEDVSSYLCTESDKIPMAQRRRFTRVEMARVLMERNQYKE 534
EELKRVKSEAIIARREPKEEAEDVSSYLCTESDKIPMAQRRRFTRVEMARVLMERNQYKE
Sbjct: 481 EELKRVKSEAIIARREPKEEAEDVSSYLCTESDKIPMAQRRRFTRVEMARVLMERNQYKE 540
Query: 535 RLMELQEAVRWTEMIRASREHPSVQEKKKSTIWQFFSRLFSSSSSPPPAKRPYPSVNIHY 594
RLMELQEAVRWTEMIRASREHPSVQEKKKSTIWQFFSRLFSSSSSPPPAKRPYPSVNIHY
Sbjct: 541 RLMELQEAVRWTEMIRASREHPSVQEKKKSTIWQFFSRLFSSSSSPPPAKRPYPSVNIHY 600
Query: 595 KSPTTAGFSQRRNHAMCPISAGSRPLEFFPDDDCTSSARREQKREQYRQVREHVRNDDGR 654
KSPTTAGFSQRRNHAMCPISAGSRPLEFFPDDDCTSSARREQKREQYRQVREHVRNDDGR
Sbjct: 601 KSPTTAGFSQRRNHAMCPISAGSRPLEFFPDDDCTSSARREQKREQYRQVREHVRNDDGR 660
Query: 655 LQACGWSLPAKYKQLSPNGGQEDTRMKNVPVPVYCRPLVEKDPTMKLWCAAGVNLSGWRP 714
LQACGWSLPAKYKQLSPNGGQEDTRMKNVPVPVYCRPLVEKDPTMKLWCAAGVNLSGWRP
Sbjct: 661 LQACGWSLPAKYKQLSPNGGQEDTRMKNVPVPVYCRPLVEKDPTMKLWCAAGVNLSGWRP 720
Query: 715 NEDDAGNGVKPAPGRDPLTCDREGDGEPKSAHTSPEKKKAKELPEMDATSSRVWILTSTL 774
NEDDAGNGVKPAPGRDPLTCDREGDGEPKSAHTSPEKKKAKELPEMDATSSRVWILTSTL
Sbjct: 721 NEDDAGNGVKPAPGRDPLTCDREGDGEPKSAHTSPEKKKAKELPEMDATSSRVWILTSTL 780
Query: 775 TTSKVVIIDANQPGTVVDQFTVCNAHVLCISSIPAASDSDYPPGEMFLDSDVNPEDPGAD 834
TTSKVVIIDANQPGTVVDQFTVCNAHVLCISSIPAASDSDYPPGEMFLDSDVNPEDPGAD
Sbjct: 781 TTSKVVIIDANQPGTVVDQFTVCNAHVLCISSIPAASDSDYPPGEMFLDSDVNPEDPGAD 840
Query: 835 GVLAGITLVGCATRCNVPRSNCSSRGDTPVLDKGQGEVATIANGKVNPSQSTEEATEATE 894
GVLAGITLVGCATRCNVPRSNCSSRGDTPVLDKGQGEVATIANGKVNPSQSTEEATEATE
Sbjct: 841 GVLAGITLVGCATRCNVPRSNCSSRGDTPVLDKGQGEVATIANGKVNPSQSTEEATEATE 900
Query: 895 VPDPGPSEPETATLRPGPLTEHVFTDPAPTPSSGPQPGSENGPEPDSSSTRPEPEPSGDP 954
VPDPGPSEPETATLRPGPLTEHVFTDPAPTPSSGPQPGSENGPEPDSSSTRPEPEPSGDP
Sbjct: 901 VPDPGPSEPETATLRPGPLTEHVFTDPAPTPSSGPQPGSENGPEPDSSSTRPEPEPSGDP 960
Query: 955 TGAGSSAAPTMWLGAQNGWLYVHSAVANWKKCLHSIKLKDSVLSLVHVKGRVLVALADGT 1014
TGAGSSAAPTMWLGAQNGWLYVHSAVANWKKCLHSIKLKDSVLSLVHVKGRVLVALADGT
Sbjct: 961 TGAGSSAAPTMWLGAQNGWLYVHSAVANWKKCLHSIKLKDSVLSLVHVKGRVLVALADGT 1020
Query: 1015 LAIFHRGEDGQWDLSNYHLMDLGHPHHSIRCMAVVYDRVWCGYKNKVHVIQPKTMQIEKS 1074
LAIFHRGEDGQWDLSNYHLMDLGHPHHSIRCMAVVYDRVWCGYKNKVHVIQPKTMQIEKS
Sbjct: 1021 LAIFHRGEDGQWDLSNYHLMDLGHPHHSIRCMAVVYDRVWCGYKNKVHVIQPKTMQIEKS 1080
Query: 1075 FDAHPRRESQVRQLAWIGDGVWVSIRLDSTLRLYHAHTHQHLQDVDIEPYVSKMLGTGKL 1134
FDAHPRRESQVRQLAWIGDGVWVSIRLDSTLRLYHAHTHQHLQDVDIEPYVSKMLGTGKL
Sbjct: 1081 FDAHPRRESQVRQLAWIGDGVWVSIRLDSTLRLYHAHTHQHLQDVDIEPYVSKMLGTGKL 1140
Query: 1135 GFSFVRITALLVAGSRLWVGTGNGVVISIPLTETVVLHRGQLLGLRANKTSPTSGEGARP 1194
GFSFVRITALLVAGSRLWVGTGNGVVISIPLTETVVLHRGQLLGLRANKTSPTSGEGARP
Sbjct: 1141 GFSFVRITALLVAGSRLWVGTGNGVVISIPLTETVVLHRGQLLGLRANKTSPTSGEGARP 1200
Query: 1195 GGIIHVYGDDSSDRAASSFIPYCSMAQAQLCFHGHRDAVKFFVSVPGNVLATLNGSVLDS 1254
GGIIHVYGDDSSDRAASSFIPYCSMAQAQLCFHGHRDAVKFFVSVPGNVLATLNGSVLDS
Sbjct: 1201 GGIIHVYGDDSSDRAASSFIPYCSMAQAQLCFHGHRDAVKFFVSVPGNVLATLNGSVLDS 1260
Query: 1255 PAEGPGPAAPASEVEGQKLRNVLVLSGGEGYIDFRIGDGEDDETEEGAGDMSQVKPVLSK 1314
PAEGPGPAAPASEVEGQKLRNVLVLSGGEGYIDFRIGDGEDDETEEGAGDMSQVKPVLSK
Sbjct: 1261 PAEGPGPAAPASEVEGQKLRNVLVLSGGEGYIDFRIGDGEDDETEEGAGDMSQVKPVLSK 1320
Query: 1315 AERSHIIVWQVSYTPE 1330
AERSHIIVWQVSYTPE
Sbjct: 1321 AERSHIIVWQVSYTPE 1336
>gi|27436920 sperm associated antigen 9 isoform 3 [Homo sapiens]
Length = 1307
Score = 1389 bits (3595), Expect = 0.0
Identities = 776/1363 (56%), Positives = 976/1363 (71%), Gaps = 94/1363 (6%)
Query: 6 MDEGGGVVVYQDDYCSGSVMSERVSGLAGSIYREFERLIHCYDEEVVKELMPLVVNVLEN 65
M+ GVV ++ SG+VMSERVSGLAGSIYREFERLI YDEEVVKELMPLVV VLEN
Sbjct: 1 MELEDGVVYQEEPGGSGAVMSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLEN 60
Query: 66 LDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKELQIQ 125
LDSV +++QEH+VELELLR+DNEQL+TQYEREKALR+ AEEKFIEFED+ EQEKK+LQ +
Sbjct: 61 LDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTR 120
Query: 126 VEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIERSKMQ 185
VE E QTRQLELKAKNYADQISRLEERE+E+KKEYNALHQRHTEMI Y+EH+ER+K+
Sbjct: 121 VESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLH 180
Query: 186 QVGGNSQTESSLPGR-RKERPTSLNVFPLADG----TVRAQIGGKLVPAGDHWHLSDLGQ 240
Q+ G+ Q ES+ R RKERP SL +FPL G T AQ GG+ P + W +L Q
Sbjct: 181 QLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGE-TPGSEQWKFQELSQ 239
Query: 241 LQSSSSYQCPQDEMSESGQSSAAATPSTTGTKSNTPTSSVPSAAVTPLNESLQPLGDYGV 300
+S +S + ++S+ G S A TP++T +N+ +++P+ TPL E +
Sbjct: 240 PRSHTSLKDELSDVSQGG--SKATTPAST---ANSDVATIPTD--TPLKEENEGF----- 287
Query: 301 GSKNSKRAREKRDSRNMEVQVTQEMRNVSIGMGSSDEWSDVQDIIDSTPELDMCPETRLD 360
K + + S+++EVQV QE RNVS G ++E S+VQ II+STPELDM +
Sbjct: 288 -VKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKDLSGY 346
Query: 361 RTGSSPTQGIVNKAFGINTDSLYHELSTAGSEVIGDVDEGADLLGEFSGMGKEVGNLLLE 420
+ S+PT+GI NKAF NT+SL+ ELS+AGS +IGDVDEGADLLG MG+EV NL+LE
Sbjct: 347 KGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLG----MGREVENLILE 402
Query: 421 NSQLLETKNALNVVKNDLIAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELEEELKRV 480
N+QLLETKNALN+VKNDLIAKVD+L+ E++VL+GELEA KQAK+KLE + +ELEEEL++
Sbjct: 403 NTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKA 462
Query: 481 KSEAIIARREPKEEAEDVSSYLCTESDKIPMAQRRRFTRVEMARVLMERNQYKERLMELQ 540
++EA AR++ K++ + IP AQR+RFTRVEMARVLMERNQYKERLMELQ
Sbjct: 463 RAEAEDARQKAKDD----------DDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQ 512
Query: 541 EAVRWTEMIRASREHPSVQEKKKSTIWQFFSRLFSSSSSPPPAKRPYPSVNIHYKSPTT- 599
EAVRWTEMIRASRE+P++QEKK+S+IWQFFSRLFSSSS+ K+P P VN+ Y +PT+
Sbjct: 513 EAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNT--TKKPEPPVNLKYNAPTSH 570
Query: 600 -AGFSQRRNHAMCPISAG-SRPLEFFPDD-DCTSSARREQKREQYRQVREHVRNDDGRLQ 656
++R+ + + S+ +F ++ + + ++RREQKREQYRQV+ HV+ +DGR+Q
Sbjct: 571 VTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQ 630
Query: 657 ACGWSLPAKYKQLSPNGGQEDTRMKNVPVPVYCRPLVEKDPTMKLWCAAGVNLSGWRPNE 716
A GWSLP KYKQ++ GQ + +MKN+PVPVY RPL EKD +MKLWCA GVNLSG + +
Sbjct: 631 AFGWSLPQKYKQVT--NGQGENKMKNLPVPVYLRPLDEKDTSMKLWCAVGVNLSGGKTRD 688
Query: 717 DDAGNGVKPAPGRDPLTCDREGDGEPKSAHTSPEK------KKAKELPEMDATSSRVWIL 770
+ G +D D EG + ++ +S +K ++ KEL + SS VWI
Sbjct: 689 GGSVVGASVFY-KDVAGLDTEGSKQRSASQSSLDKLDQELKEQQKELKNQEELSSLVWIC 747
Query: 771 TSTLTTSKVVIIDANQPGTVVDQFTVCNAHVLCISSIPAASDSDYPPGEMFLDSD----- 825
TST + +KV+IIDA QPG ++D FTVCN+HVLCI+S+P A ++DYP GE +S
Sbjct: 748 TSTHSATKVLIIDAVQPGNILDSFTVCNSHVLCIASVPGARETDYPAGEDLSESGQVDKA 807
Query: 826 ------VNPEDPGADGVLAGITLVGCATR-CNVPRSNCSSRGDTPVLDKGQGEVATIANG 878
+ D +L GIT+VGC+ ++ S+ G +PV+DK A N
Sbjct: 808 SLCGSMTSNSSAETDSLLGGITVVGCSAEGVTGAATSPSTNGASPVMDKPPEMEAE--NS 865
Query: 879 KVNPSQST-EEATEATEVPDPGPSEPETATLRPGPLTEHVFTDPAPTP-----SSGPQPG 932
+V+ + T EEATEATE + G +E + G TEHVFTDP S Q
Sbjct: 866 EVDENVPTAEEATEATE-GNAGSAEDTVDISQTGVYTEHVFTDPLGVQIPEDLSPVYQSS 924
Query: 933 SENGPEPDSSSTRP-EPEPSGDPTGAGSSAAPTMWLGAQNGWLYVHSAVANWKKCLHSIK 991
+++ D S P E + + SS PTMWLGAQNG LYVHS+VA W+KCLHSIK
Sbjct: 925 NDSDAYKDQISVLPNEQDLVREEAQKMSSLLPTMWLGAQNGCLYVHSSVAQWRKCLHSIK 984
Query: 992 LKDSVLSLVHVKGRVLVALADGTLAIFHRGEDGQWDLSNYHLMDLGHPHHSIRCMAVVYD 1051
LKDS+LS+VHVKG VLVALADGTLAIFHRG DGQWDLSNYHL+DLG PHHSIRCM VV+D
Sbjct: 985 LKDSILSIVHVKGIVLVALADGTLAIFHRGVDGQWDLSNYHLLDLGRPHHSIRCMTVVHD 1044
Query: 1052 RVWCGYKNKVHVIQPKTMQIEKSFDAHPRRESQVRQLAWIGDGVWVSIRLDSTLRLYHAH 1111
+VWCGY+NK++V+QPK M+IEKSFDAHPR+ESQVRQLAW+GDGVWVSIRLDSTLRLYHAH
Sbjct: 1045 KVWCGYRNKIYVVQPKAMKIEKSFDAHPRKESQVRQLAWVGDGVWVSIRLDSTLRLYHAH 1104
Query: 1112 THQHLQDVDIEPYVSKMLGTGKLGFSFVRITALLVAGSRLWVGTGNGVVISIPLTETVVL 1171
T+QHLQDVDIEPYVSKMLGTGKLGFSFVRITAL+V+ +RLWVGTGNGV+ISIPLTET
Sbjct: 1105 TYQHLQDVDIEPYVSKMLGTGKLGFSFVRITALMVSCNRLWVGTGNGVIISIPLTET--- 1161
Query: 1172 HRGQLLGLRANKTSPTSGEGARPGGIIHVYGDDSSDRAA-SSFIPYCSMAQAQLCFHGHR 1230
NKTS G RPG +I VYGD++SD+ +FIPYCSMA AQLCFHGHR
Sbjct: 1162 ----------NKTSGVPGN--RPGSVIRVYGDENSDKVTPGTFIPYCSMAHAQLCFHGHR 1209
Query: 1231 DAVKFFVSVPGNVL---ATLNGSVLDSPAEGPGPAAPASEVEGQKLRNVLVLSGGEGYID 1287
DAVKFFV+VPG V+ ++ +G+ L GP P S+ L+++LV+SGGEGYID
Sbjct: 1210 DAVKFFVAVPGQVISPQSSSSGTDLTGDKAGPSAQEPGSQT---PLKSMLVISGGEGYID 1266
Query: 1288 FRIGDGEDDETEEGAGDMSQVKPVLSKAERSHIIVWQVSYTPE 1330
FR+GD E E+E G+ ++P ++KAERSH+IVWQV Y E
Sbjct: 1267 FRMGD-EGGESEL-LGEDLPLEPSVTKAERSHLIVWQVMYGNE 1307
>gi|194578923 sperm associated antigen 9 isoform 1 [Homo sapiens]
Length = 1321
Score = 1387 bits (3589), Expect = 0.0
Identities = 776/1366 (56%), Positives = 971/1366 (71%), Gaps = 86/1366 (6%)
Query: 6 MDEGGGVVVYQDDYCSGSVMSERVSGLAGSIYREFERLIHCYDEEVVKELMPLVVNVLEN 65
M+ GVV ++ SG+VMSERVSGLAGSIYREFERLI YDEEVVKELMPLVV VLEN
Sbjct: 1 MELEDGVVYQEEPGGSGAVMSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLEN 60
Query: 66 LDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKELQIQ 125
LDSV +++QEH+VELELLR+DNEQL+TQYEREKALR+ AEEKFIEFED+ EQEKK+LQ +
Sbjct: 61 LDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTR 120
Query: 126 VEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIERSKMQ 185
VE E QTRQLELKAKNYADQISRLEERE+E+KKEYNALHQRHTEMI Y+EH+ER+K+
Sbjct: 121 VESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLH 180
Query: 186 QVGGNSQTESSLPGR-RKERPTSLNVFPLADG----TVRAQIGGKLVPAGDHWHLSDLGQ 240
Q+ G+ Q ES+ R RKERP SL +FPL G T AQ GG+ P + W +L Q
Sbjct: 181 QLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGE-TPGSEQWKFQELSQ 239
Query: 241 LQSSSSYQCPQDEMSESG--QSSAAATPSTTGTKSNTPTSSVPSAAVTPLNESLQPLGDY 298
+S +S + + Q + S G+K+ TP S+ S T ++ PL +
Sbjct: 240 PRSHTSLKVSNSPEPQKAVEQEDELSDVSQGGSKATTPASTANSDVATIPTDT--PLKEE 297
Query: 299 GVGSKNSKRAREKRD-SRNMEVQVTQEMRNVSIGMGSSDEWSDVQDIIDSTPELDMCPET 357
G A K + S+++EVQV QE RNVS G ++E S+VQ II+STPELDM +
Sbjct: 298 NEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKDL 357
Query: 358 RLDRTGSSPTQGIVNKAFGINTDSLYHELSTAGSEVIGDVDEGADLLGEFSGMGKEVGNL 417
+ S+PT+GI NKAF NT+SL+ ELS+AGS +IGDVDEGADLLG MG+EV NL
Sbjct: 358 SGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLG----MGREVENL 413
Query: 418 LLENSQLLETKNALNVVKNDLIAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELEEEL 477
+LEN+QLLETKNALN+VKNDLIAKVD+L+ E++VL+GELEA KQAK+KLE + +ELEEEL
Sbjct: 414 ILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEEL 473
Query: 478 KRVKSEAIIARREPKEEAEDVSSYLCTESDKIPMAQRRRFTRVEMARVLMERNQYKERLM 537
++ ++EA AR++ K++ + IP AQR+RFTRVEMARVLMERNQYKERLM
Sbjct: 474 RKARAEAEDARQKAKDD----------DDSDIPTAQRKRFTRVEMARVLMERNQYKERLM 523
Query: 538 ELQEAVRWTEMIRASREHPSVQEKKKSTIWQFFSRLFSSSSSPPPAKRPYPSVNIHYKSP 597
ELQEAVRWTEMIRASRE+P++QEKK+S+IWQFFSRLFSSSS+ K+P P VN+ Y +P
Sbjct: 524 ELQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNT--TKKPEPPVNLKYNAP 581
Query: 598 TT--AGFSQRRNHAMCPISAG-SRPLEFFPDD-DCTSSARREQKREQYRQVREHVRNDDG 653
T+ ++R+ + + S+ +F ++ + + ++RREQKREQYRQV+ HV+ +DG
Sbjct: 582 TSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDG 641
Query: 654 RLQACGWSLPAKYKQLSPNGGQEDTRMKNVPVPVYCRPLVEKDPTMKLWCAAGVNLSGWR 713
R+QA GWSLP KYKQ++ GQ + +MKN+PVPVY RPL EKD +MKLWCA GVNLSG +
Sbjct: 642 RVQAFGWSLPQKYKQVT--NGQGENKMKNLPVPVYLRPLDEKDTSMKLWCAVGVNLSGGK 699
Query: 714 PNEDDAGNGVKPAPGRDPLTCDREGDGEPKSAHTSPEK------KKAKELPEMDATSSRV 767
+ + G +D D EG + ++ +S +K ++ KEL + SS V
Sbjct: 700 TRDGGSVVGASVFY-KDVAGLDTEGSKQRSASQSSLDKLDQELKEQQKELKNQEELSSLV 758
Query: 768 WILTSTLTTSKVVIIDANQPGTVVDQFTVCNAHVLCISSIPAASDSDYPPGEMFLDSD-- 825
WI TST + +KV+IIDA QPG ++D FTVCN+HVLCI+S+P A ++DYP GE +S
Sbjct: 759 WICTSTHSATKVLIIDAVQPGNILDSFTVCNSHVLCIASVPGARETDYPAGEDLSESGQV 818
Query: 826 ---------VNPEDPGADGVLAGITLVGCATR-CNVPRSNCSSRGDTPVLDKGQGEVATI 875
+ D +L GIT+VGC+ ++ S+ G +PV+DK A
Sbjct: 819 DKASLCGSMTSNSSAETDSLLGGITVVGCSAEGVTGAATSPSTNGASPVMDKPPEMEAE- 877
Query: 876 ANGKVNPSQST-EEATEATEVPDPGPSEPETATLRPGPLTEHVFTDPAPTP-----SSGP 929
N +V+ + T EEATEATE + G +E + G TEHVFTDP S
Sbjct: 878 -NSEVDENVPTAEEATEATE-GNAGSAEDTVDISQTGVYTEHVFTDPLGVQIPEDLSPVY 935
Query: 930 QPGSENGPEPDSSSTRP-EPEPSGDPTGAGSSAAPTMWLGAQNGWLYVHSAVANWKKCLH 988
Q +++ D S P E + + SS PTMWLGAQNG LYVHS+VA W+KCLH
Sbjct: 936 QSSNDSDAYKDQISVLPNEQDLVREEAQKMSSLLPTMWLGAQNGCLYVHSSVAQWRKCLH 995
Query: 989 SIKLKDSVLSLVHVKGRVLVALADGTLAIFHRGEDGQWDLSNYHLMDLGHPHHSIRCMAV 1048
SIKLKDS+LS+VHVKG VLVALADGTLAIFHRG DGQWDLSNYHL+DLG PHHSIRCM V
Sbjct: 996 SIKLKDSILSIVHVKGIVLVALADGTLAIFHRGVDGQWDLSNYHLLDLGRPHHSIRCMTV 1055
Query: 1049 VYDRVWCGYKNKVHVIQPKTMQIEKSFDAHPRRESQVRQLAWIGDGVWVSIRLDSTLRLY 1108
V+D+VWCGY+NK++V+QPK M+IEKSFDAHPR+ESQVRQLAW+GDGVWVSIRLDSTLRLY
Sbjct: 1056 VHDKVWCGYRNKIYVVQPKAMKIEKSFDAHPRKESQVRQLAWVGDGVWVSIRLDSTLRLY 1115
Query: 1109 HAHTHQHLQDVDIEPYVSKMLGTGKLGFSFVRITALLVAGSRLWVGTGNGVVISIPLTET 1168
HAHT+QHLQDVDIEPYVSKMLGTGKLGFSFVRITAL+V+ +RLWVGTGNGV+ISIPLTET
Sbjct: 1116 HAHTYQHLQDVDIEPYVSKMLGTGKLGFSFVRITALMVSCNRLWVGTGNGVIISIPLTET 1175
Query: 1169 VVLHRGQLLGLRANKTSPTSGEGARPGGIIHVYGDDSSDRAA-SSFIPYCSMAQAQLCFH 1227
NKTS G RPG +I VYGD++SD+ +FIPYCSMA AQLCFH
Sbjct: 1176 -------------NKTSGVPGN--RPGSVIRVYGDENSDKVTPGTFIPYCSMAHAQLCFH 1220
Query: 1228 GHRDAVKFFVSVPGNVL---ATLNGSVLDSPAEGPGPAAPASEVEGQKLRNVLVLSGGEG 1284
GHRDAVKFFV+VPG V+ ++ +G+ L GP P S+ L+++LV+SGGEG
Sbjct: 1221 GHRDAVKFFVAVPGQVISPQSSSSGTDLTGDKAGPSAQEPGSQT---PLKSMLVISGGEG 1277
Query: 1285 YIDFRIGDGEDDETEEGAGDMSQVKPVLSKAERSHIIVWQVSYTPE 1330
YIDFR+GD E E+E G+ ++P ++KAERSH+IVWQV Y E
Sbjct: 1278 YIDFRMGD-EGGESEL-LGEDLPLEPSVTKAERSHLIVWQVMYGNE 1321
>gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17 [Homo
sapiens]
Length = 2063
Score = 144 bits (363), Expect = 6e-34
Identities = 155/602 (25%), Positives = 241/602 (40%), Gaps = 91/602 (15%)
Query: 764 SSRVWILTSTLTTSKVVIIDANQPGTVVDQFTVCNAHVLCISSIPAASDSDY--PPGEMF 821
S VW+ S +V ++ V VC+A +LCI ++P + PP +
Sbjct: 1513 SPEVWVCNSDGYVGQVCLLSLRAEPDVEACIAVCSARILCIGAVPGLQPRCHREPPPSLR 1572
Query: 822 LDSDVNPEDPGADGVLAGITLVGCATRCNVPRSNC-------SSRGDTPVLDKGQGEVAT 874
+ PE G + + AT C S TP L +G
Sbjct: 1573 SPPETAPEPAGPELDVEAAADEEAATLAEPGPQPCLHISIAGSGLEMTPGLGEGDPRPEL 1632
Query: 875 I-----ANGKVNPSQSTEEATEAT-----------EVPDPGPSEPETAT----LRPGPLT 914
+ ++ + +PS S ++A+ E P + ET + PG L
Sbjct: 1633 VPFDSDSDDESSPSPSGTLQSQASRSTISSSFGNEETPSSKEATAETTSSEEEQEPGFLP 1692
Query: 915 EHVFTDPAPTPSSGPQPGSENGPEPDSSSTRPEPEP--SGDPTGAGSSAAPTMWLGAQNG 972
P + P G S TR E S DP SS +WLG ++G
Sbjct: 1693 LSGSFGPGGPCGTSPMDGRALRRSSHGSFTRGSLEDLLSVDPEAYQSS----VWLGTEDG 1748
Query: 973 WLYVHSAVANWKKCLHSIKLKD--SVLSLVHVKGRVLVALADGTLAIFHRGEDGQWDLSN 1030
++V+ + + + +S+KL+ SV ++++ +V V+LA+G L ++ R WD N
Sbjct: 1749 CVHVYQSSDSIRDRRNSMKLQHAASVTCILYLNNQVFVSLANGELVVYQREAGHFWDPQN 1808
Query: 1031 YHLMDLGHPHHSIRCMAVVYDRVWCGYKNKVHVIQPKTMQIEKSFDAHPRRESQVRQLAW 1090
+ + LG I M V R+WCG +N+V V+ P T+Q+E F V +
Sbjct: 1809 FKSVTLGTQGSPITKMVSVGGRLWCGCQNRVLVLSPDTLQLEHMFYVGQDSSRCVACMVD 1868
Query: 1091 IGDGVWVSIRLDSTLRLYHAHTHQHLQDVDIEPYVSKMLGTG-----KLGFSFVRITALL 1145
GVWV+++ + + LYH T + L +VD+ P V +ML + + +RITALL
Sbjct: 1869 SSLGVWVTLKGSAHVCLYHPDTFEQLAEVDVTPPVHRMLAGSDAIIRQHKAACLRITALL 1928
Query: 1146 VAGSRLWVGTGNGVVISIPLTE-TVVLHRGQLLGLRANKTSPTSGEGARPGGIIHVYGDD 1204
V LWVGT GVV+++P + TV R L + T G + V D
Sbjct: 1929 VCEELLWVGTSAGVVLTMPTSPGTVSCPRAPL-----SPTGLGQGHTGHVRFLAAVQLPD 1983
Query: 1205 SSDRAASSFIPYCSMAQAQLCFHGHRDAVKFFVSVPGNVLATLNGSVLDSP-AEGPGPAA 1263
+ + P +L HR DSP GP PA
Sbjct: 1984 GFNLLCPTPPPPPDTGPEKLPSLEHR----------------------DSPWHRGPAPAR 2021
Query: 1264 PASEVEGQKLRNVLVLSGGEGYIDFRIGDGEDDETEEGAGDMSQVKPVLSKAERSHIIVW 1323
P +LV+SGG+GY DFR+ G +E D S +H+++W
Sbjct: 2022 P----------KMLVISGGDGYEDFRLSSGGGSSSETVGRDDS----------TNHLLLW 2061
Query: 1324 QV 1325
+V
Sbjct: 2062 RV 2063
>gi|58761492 Rho guanine nucleotide exchange factor (GEF) 10-like
isoform 1 [Homo sapiens]
Length = 1279
Score = 112 bits (280), Expect = 2e-24
Identities = 80/261 (30%), Positives = 130/261 (49%), Gaps = 18/261 (6%)
Query: 909 RPGPLTEHVFTDPAPTPSSGPQPGSENGPE-PDSSSTRPEPEPSGDPTGAGSSAAPTMWL 967
RP P T F P + P E PE + + +R E DP+ ++ PT+ L
Sbjct: 846 RPSPRTVKSF------PLAAPVLCMEYIPELEEEAESRDESPTVADPS---ATVHPTICL 896
Query: 968 GAQNGWLYVHSAVANWKKCLHSIKLK--DSVLSLVHVKGRVLVALADGTLAIFHRGEDGQ 1025
G Q+G + ++S+V +CL S + VL L H +L L DGTLA + R G
Sbjct: 897 GLQDGSILLYSSVDTGTQCLVSCRSPGLQPVLCLRHSPFHLLAGLQDGTLAAYPRTSGGV 956
Query: 1026 -WDLSNYHLMDLGHPHHSIRCMAVVYDRVWCGYKNKVHVIQPKTMQIEKSFDAHPRRESQ 1084
WDL + + P +R + + D VW +V V++ T+Q ++SF+AH
Sbjct: 957 LWDLESPPVCLTVGPG-PVRTLLSLEDAVWASCGPRVTVLEATTLQPQQSFEAHQDEAVS 1015
Query: 1085 VRQLAWIGDGVWVSIRLDSTLRLYHAHTHQHLQDVDIEPYVSKMLGTGKLGFSFVRITAL 1144
V + G GVW++ +++RL+H T +HLQ+++I + +L G + +T+L
Sbjct: 1016 VTHMVKAGSGVWMAFSSGTSIRLFHTETLEHLQEINIATRTTFLLP----GQKHLCVTSL 1071
Query: 1145 LVAGSRLWVGTGNGVVISIPL 1165
L+ LWVGT GV++ +P+
Sbjct: 1072 LICQGLLWVGTDQGVIVLLPV 1092
>gi|74136547 Rho guanine nucleotide exchange factor (GEF) 10-like
isoform 2 [Homo sapiens]
Length = 1240
Score = 112 bits (280), Expect = 2e-24
Identities = 80/261 (30%), Positives = 130/261 (49%), Gaps = 18/261 (6%)
Query: 909 RPGPLTEHVFTDPAPTPSSGPQPGSENGPE-PDSSSTRPEPEPSGDPTGAGSSAAPTMWL 967
RP P T F P + P E PE + + +R E DP+ ++ PT+ L
Sbjct: 807 RPSPRTVKSF------PLAAPVLCMEYIPELEEEAESRDESPTVADPS---ATVHPTICL 857
Query: 968 GAQNGWLYVHSAVANWKKCLHSIKLK--DSVLSLVHVKGRVLVALADGTLAIFHRGEDGQ 1025
G Q+G + ++S+V +CL S + VL L H +L L DGTLA + R G
Sbjct: 858 GLQDGSILLYSSVDTGTQCLVSCRSPGLQPVLCLRHSPFHLLAGLQDGTLAAYPRTSGGV 917
Query: 1026 -WDLSNYHLMDLGHPHHSIRCMAVVYDRVWCGYKNKVHVIQPKTMQIEKSFDAHPRRESQ 1084
WDL + + P +R + + D VW +V V++ T+Q ++SF+AH
Sbjct: 918 LWDLESPPVCLTVGPG-PVRTLLSLEDAVWASCGPRVTVLEATTLQPQQSFEAHQDEAVS 976
Query: 1085 VRQLAWIGDGVWVSIRLDSTLRLYHAHTHQHLQDVDIEPYVSKMLGTGKLGFSFVRITAL 1144
V + G GVW++ +++RL+H T +HLQ+++I + +L G + +T+L
Sbjct: 977 VTHMVKAGSGVWMAFSSGTSIRLFHTETLEHLQEINIATRTTFLLP----GQKHLCVTSL 1032
Query: 1145 LVAGSRLWVGTGNGVVISIPL 1165
L+ LWVGT GV++ +P+
Sbjct: 1033 LICQGLLWVGTDQGVIVLLPV 1053
>gi|62548864 Rho guanine nucleotide exchange factor 10 [Homo sapiens]
Length = 1344
Score = 102 bits (254), Expect = 2e-21
Identities = 64/227 (28%), Positives = 110/227 (48%), Gaps = 17/227 (7%)
Query: 946 PEPEPSGDPTGAGSSAAPTMWLGAQNGWLYVHSAVANWKKCLHSIKL-------KDSVLS 998
P P + +S PT+ +G + G + ++ + KK ++L K +V+S
Sbjct: 947 PGAPPDPETPAVRASDVPTICVGTEEGSISIYKSSQGSKK----VRLQHFFTPEKSTVMS 1002
Query: 999 LVHVKGRVLVALADGTLAIFHRGEDGQWDLSNYHLMDLGHPHHSIRCMAVVYDRVWCGYK 1058
L + L +G +A + R DG WD ++ LG +R + ++ D +W
Sbjct: 1003 LACTSQSLYAGLVNGAVASYARAPDGSWDSEPQKVIKLGVL--PVRSLLMMEDTLWAASG 1060
Query: 1059 NKVHVIQPKTMQIEKSFDAHPRRESQVRQLAWIGDGVWVSIRLDSTLRLYHAHTHQHLQD 1118
+V +I +T +E +AH + +A G G+W++ STLRL+H T +HLQD
Sbjct: 1061 GQVFIISVETHAVEGQLEAHQEEGMVISHMAVSGVGIWIAFTSGSTLRLFHTETLKHLQD 1120
Query: 1119 VDIEPYVSKMLGTGKLGFSFVRITALLVAGSRLWVGTGNGVVISIPL 1165
++I V ML G + +T+LLV L VGT GV++++P+
Sbjct: 1121 INIATPVHNMLP----GHQRLSVTSLLVCHGLLMVGTSLGVLVALPV 1163
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 58.9 bits (141), Expect = 3e-08
Identities = 97/478 (20%), Positives = 191/478 (39%), Gaps = 55/478 (11%)
Query: 76 HEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKELQIQVEHYEFQTRQ 135
HE+E L E++ Q ER+K ++ ++ E+ LE+E+ Q + +
Sbjct: 925 HEMEARLEEEEDRGQQLQAERKKMA-----QQMLDLEEQLEEEEAARQ----KLQLEKVT 975
Query: 136 LELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIERSKMQQVGGNSQTE- 194
E K K D+I ++++ +++ KE L +R +++ E E++K N
Sbjct: 976 AEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESM 1035
Query: 195 -SSLPGRRKERPTSLNVFPLADGTVRAQIGGKLVPAGD-HWHLSDLGQLQSSSSYQCPQD 252
S L R K+ S ++ ++ G A D H ++DL + Q +
Sbjct: 1036 ISELEVRLKKEEKSRQELE----KLKRKLEG---DASDFHEQIADLQAQIAELKMQLAKK 1088
Query: 253 EMSESGQSSAAATPSTTGTKSNTPTSSVPSAAVTPLNESLQPLGDYGVGSKNSKRAREKR 312
E E Q++ A K+N A+ + E + D + + AR K
Sbjct: 1089 E--EELQAALARLDDEIAQKNN---------ALKKIRELEGHISDLQEDLDSERAARNKA 1137
Query: 313 DSRNMEVQVTQEMRNVSIGMGSSDEWSDVQDIIDSTPELDMCPETRLDRTGSSPTQGIVN 372
+ + ++ E ++++D +DST E R R ++
Sbjct: 1138 EKQKRDLGEELEALK-----------TELEDTLDSTATQQ---ELRAKR---EQEVTVLK 1180
Query: 373 KAFGINTDSLYHELSTAGSEVIGDVDEGADLLGEF----SGMGKEVGNLLLENSQLLETK 428
KA T S ++ + V+E + L +F + + K L EN+ L
Sbjct: 1181 KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGEL 1240
Query: 429 NALNVVKNDLIAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELEEELKRVKSEAIIAR 488
L K ++ K +L + + L+ + ++A+ +L +++ +L+ E++ V A
Sbjct: 1241 RVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAE 1300
Query: 489 REPKEEAEDVSSYLCTESDKIPMAQRRRFTRVEMARVLM----ERNQYKERLMELQEA 542
+ + A+DV+S D + Q ++ ++ L ERN +++L E EA
Sbjct: 1301 GKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEA 1358
Score = 48.1 bits (113), Expect = 5e-05
Identities = 102/544 (18%), Positives = 213/544 (39%), Gaps = 62/544 (11%)
Query: 63 LENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKEL 122
L LD +++ ++ L L + E+A R +AE++ + + LE K EL
Sbjct: 1096 LARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTEL 1155
Query: 123 QIQVEHYEFQTRQLELKAKNYADQI---SRLEERESEMKKEYNALHQRHTEMIQTYVEHI 179
+ + + Q EL+AK + L+E + + + Q+H + ++ E +
Sbjct: 1156 E---DTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL 1212
Query: 180 ERSKMQQVGGNSQTESSLPGRRKERPTSLNVFPLADGTVRAQIGGKLVPAGDHWHLSDLG 239
E+ K + + + +L + L V G + ++ K + +
Sbjct: 1213 EQFKRAK-ANLDKNKQTLEKENADLAGELRVL----GQAKQEVEHKKKKLE-----AQVQ 1262
Query: 240 QLQSS-SSYQCPQDEMSESGQSSAAATPSTTGTKSNTPTSSVPSAA-VTPLNESLQPLGD 297
+LQS S + + E+++ S TG + ++ A V L+ LQ +
Sbjct: 1263 ELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQE 1322
Query: 298 YGVGSKNSK-----RAREKRDSRN-MEVQVTQEM-------RNVS-IGMGSSDEWSDVQD 343
K + R+ + RN ++ Q+ +EM R++S + + SD +QD
Sbjct: 1323 LLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQD 1382
Query: 344 IIDSTPELDMCPETRLDRTGSSPTQGIVNKAFGIN-TDSLYHELSTAGSEVIGDVDEGAD 402
+ L+ + R + + TQ KA + + + L +++ D+D
Sbjct: 1383 FASTVEALEE-GKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQ 1441
Query: 403 LLGEFSGMGKEVGNLLLENSQL-----------------LETKNALNVVK--NDLIAKVD 443
L+ ++ LL E + ETK AL++ + + + +
Sbjct: 1442 LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETK-ALSLARALEEALEAKE 1500
Query: 444 QLSGEQEVLRGELEAAKQAKVKLENRIKELEEELKRVKSEAIIARREPKEEAEDVSSYL- 502
+L ++L+ E+E +K + + ELE+ + ++++ E K + E++ L
Sbjct: 1501 ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ----MEEMKTQLEELEDELQ 1556
Query: 503 CTESDKIPMAQRRRFTRVEMARVLM---ERNQYKERLMELQEAVRWTEMIRASREHPSVQ 559
TE K+ + + + + R L E+N+ K R ++ Q TE+ ++
Sbjct: 1557 ATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAA 1616
Query: 560 EKKK 563
KK
Sbjct: 1617 AAKK 1620
Score = 43.5 bits (101), Expect = 0.001
Identities = 101/538 (18%), Positives = 214/538 (39%), Gaps = 61/538 (11%)
Query: 49 EEVVKELMPLVVNVLENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKF 108
EE K + N+ + + + + E L+++ + L+ + ++ L E+K
Sbjct: 1391 EEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQ 1450
Query: 109 IEFEDALEQEKK---ELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALH 165
+F+ L +EK + + + E + R+ E KA + A + E + E+
Sbjct: 1451 RKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL-------- 1502
Query: 166 QRHTEMIQTYVEHIERSKMQQVGGN----SQTESSLPGRRKERPTSLNVFP-----LADG 216
+R +M++ +E + SK VG N +++ +L + +E T L D
Sbjct: 1503 ERTNKMLKAEMEDLVSSK-DDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDA 1561
Query: 217 TVRAQIGGKLVP--------AGDHWHLSDLGQLQSS-SSYQCPQDEMSESGQSSAAATPS 267
+R ++ + + A D + QLQ Y+ ++ + +AAA
Sbjct: 1562 KLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKK 1621
Query: 268 TTGTKSNTPTSSVPSAAVTPLNESLQPLGDYGVGSKNSKRAREKRDSRNMEVQVT---QE 324
G + + +A+ E+++ L K+ +R E + E+ T E
Sbjct: 1622 LEGDLKDLELQA--DSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENE 1679
Query: 325 MRNVSIGMGSSDEWSDVQDIIDSTPELDMCPETRLDRTGSSPTQGIVNKAFGINTDSLYH 384
+ S+ D+ + + D+ E + SS + + ++
Sbjct: 1680 KKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1739
Query: 385 ELSTAGSEVIGDVDEGADLLGEFSGMGKEVGN-LLLENSQLLETKNALNVVKNDLIAKVD 443
+L E G+++ +D + + + +++ N L E S + ++A
Sbjct: 1740 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQ----------- 1788
Query: 444 QLSGEQEVLRG---ELEAAKQAKVK-----LENRIKELEEELKRVKSEAIIARREPKEEA 495
QL + + LR E+E A ++K K LE +I +LEE++++ E A + K++
Sbjct: 1789 QLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKD 1848
Query: 496 EDVSSYLCTESDKIPMAQRRRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASR 553
+ + L D+ MA++ + E A + K+ +L+EA ++ I A+R
Sbjct: 1849 KKLKEILLQVEDERKMAEQYK----EQAE--KGNARVKQLKRQLEEAEEESQRINANR 1900
Score = 42.7 bits (99), Expect = 0.002
Identities = 33/137 (24%), Positives = 66/137 (48%), Gaps = 15/137 (10%)
Query: 61 NVLENLDSVLSENQEHEVEL-------ELLREDNEQLLTQYEREK----ALRRQAEEKFI 109
N +E++ +L+E + ++L +D ++LL + R+K RQ EE+
Sbjct: 1287 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1346
Query: 110 EFEDALEQE---KKELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQ 166
+D L++E K+ L+ + Q + K +++A + LEE + +KE L Q
Sbjct: 1347 SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ 1406
Query: 167 RHTEMIQTYVEHIERSK 183
++ E Y + +E++K
Sbjct: 1407 QYEEKAAAY-DKLEKTK 1422
Score = 38.9 bits (89), Expect = 0.033
Identities = 31/136 (22%), Positives = 60/136 (44%), Gaps = 11/136 (8%)
Query: 439 IAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELEE------ELKRVKSEAIIARREPK 492
+ +V + E + EL+ K+ + K EN +KELE+ E K + E + A E
Sbjct: 844 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 903
Query: 493 EEAEDVSSYLCTESDKIPMAQRRRFTRVEM-----ARVLMERNQYKERLMELQEAVRWTE 547
EAE++ L + ++ R+E ++ ER + +++++L+E + E
Sbjct: 904 AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEE 963
Query: 548 MIRASREHPSVQEKKK 563
R + V + K
Sbjct: 964 AARQKLQLEKVTAEAK 979
Score = 35.8 bits (81), Expect = 0.28
Identities = 26/127 (20%), Positives = 61/127 (48%), Gaps = 3/127 (2%)
Query: 48 DEEVVKELMPLVVNVLENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEK 107
+E+ K L ++ + E+L + ++ ++E E L E+ L+ + +R+ E +
Sbjct: 1678 NEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEAR 1737
Query: 108 FIEFEDALEQEKKELQIQVEHYEFQTRQLELKAKNYADQISRLEERES---EMKKEYNAL 164
+ E+ LE+E+ ++ + T+Q E + A + S ++ ES +++++ L
Sbjct: 1738 IAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKEL 1797
Query: 165 HQRHTEM 171
+ EM
Sbjct: 1798 RSKLHEM 1804
Score = 32.3 bits (72), Expect = 3.1
Identities = 27/141 (19%), Positives = 58/141 (41%), Gaps = 4/141 (2%)
Query: 27 ERVSGLAGSIYREFERLIHCYDEEVVKELMPLVVNVLENLDSVLSENQEHEVELELLRED 86
ER + S E E + + + L + + E ++ E Q L+ +
Sbjct: 1791 ERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKK 1850
Query: 87 NEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKELQIQVEHYEFQTRQLELKAKNYADQ 146
+++L Q E E+ + Q +E+ + K+L+ Q+E E +++++ + +
Sbjct: 1851 LKEILLQVEDERKMAEQYKEQ----AEKGNARVKQLKRQLEEAEEESQRINANRRKLQRE 1906
Query: 147 ISRLEERESEMKKEYNALHQR 167
+ E M +E NAL +
Sbjct: 1907 LDEATESNEAMGREVNALKSK 1927
Score = 31.6 bits (70), Expect = 5.3
Identities = 18/71 (25%), Positives = 40/71 (56%), Gaps = 4/71 (5%)
Query: 108 FIEFEDALEQEKKELQIQVEHYEFQ-TRQLELKAKNYADQISRLEERESEMKKEYNALHQ 166
F + + L+ ++E ++Q + E Q T++ + KA+N ++ LE++ S++ +E N L +
Sbjct: 838 FTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAEN---ELKELEQKHSQLTEEKNLLQE 894
Query: 167 RHTEMIQTYVE 177
+ + Y E
Sbjct: 895 QLQAETELYAE 905
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 58.9 bits (141), Expect = 3e-08
Identities = 97/478 (20%), Positives = 191/478 (39%), Gaps = 55/478 (11%)
Query: 76 HEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKELQIQVEHYEFQTRQ 135
HE+E L E++ Q ER+K ++ ++ E+ LE+E+ Q + +
Sbjct: 932 HEMEARLEEEEDRGQQLQAERKKMA-----QQMLDLEEQLEEEEAARQ----KLQLEKVT 982
Query: 136 LELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIERSKMQQVGGNSQTE- 194
E K K D+I ++++ +++ KE L +R +++ E E++K N
Sbjct: 983 AEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESM 1042
Query: 195 -SSLPGRRKERPTSLNVFPLADGTVRAQIGGKLVPAGD-HWHLSDLGQLQSSSSYQCPQD 252
S L R K+ S ++ ++ G A D H ++DL + Q +
Sbjct: 1043 ISELEVRLKKEEKSRQELE----KLKRKLEG---DASDFHEQIADLQAQIAELKMQLAKK 1095
Query: 253 EMSESGQSSAAATPSTTGTKSNTPTSSVPSAAVTPLNESLQPLGDYGVGSKNSKRAREKR 312
E E Q++ A K+N A+ + E + D + + AR K
Sbjct: 1096 E--EELQAALARLDDEIAQKNN---------ALKKIRELEGHISDLQEDLDSERAARNKA 1144
Query: 313 DSRNMEVQVTQEMRNVSIGMGSSDEWSDVQDIIDSTPELDMCPETRLDRTGSSPTQGIVN 372
+ + ++ E ++++D +DST E R R ++
Sbjct: 1145 EKQKRDLGEELEALK-----------TELEDTLDSTATQQ---ELRAKR---EQEVTVLK 1187
Query: 373 KAFGINTDSLYHELSTAGSEVIGDVDEGADLLGEF----SGMGKEVGNLLLENSQLLETK 428
KA T S ++ + V+E + L +F + + K L EN+ L
Sbjct: 1188 KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGEL 1247
Query: 429 NALNVVKNDLIAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELEEELKRVKSEAIIAR 488
L K ++ K +L + + L+ + ++A+ +L +++ +L+ E++ V A
Sbjct: 1248 RVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAE 1307
Query: 489 REPKEEAEDVSSYLCTESDKIPMAQRRRFTRVEMARVLM----ERNQYKERLMELQEA 542
+ + A+DV+S D + Q ++ ++ L ERN +++L E EA
Sbjct: 1308 GKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEA 1365
Score = 48.1 bits (113), Expect = 5e-05
Identities = 102/544 (18%), Positives = 213/544 (39%), Gaps = 62/544 (11%)
Query: 63 LENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKEL 122
L LD +++ ++ L L + E+A R +AE++ + + LE K EL
Sbjct: 1103 LARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTEL 1162
Query: 123 QIQVEHYEFQTRQLELKAKNYADQI---SRLEERESEMKKEYNALHQRHTEMIQTYVEHI 179
+ + + Q EL+AK + L+E + + + Q+H + ++ E +
Sbjct: 1163 E---DTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL 1219
Query: 180 ERSKMQQVGGNSQTESSLPGRRKERPTSLNVFPLADGTVRAQIGGKLVPAGDHWHLSDLG 239
E+ K + + + +L + L V G + ++ K + +
Sbjct: 1220 EQFKRAK-ANLDKNKQTLEKENADLAGELRVL----GQAKQEVEHKKKKLE-----AQVQ 1269
Query: 240 QLQSS-SSYQCPQDEMSESGQSSAAATPSTTGTKSNTPTSSVPSAA-VTPLNESLQPLGD 297
+LQS S + + E+++ S TG + ++ A V L+ LQ +
Sbjct: 1270 ELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQE 1329
Query: 298 YGVGSKNSK-----RAREKRDSRN-MEVQVTQEM-------RNVS-IGMGSSDEWSDVQD 343
K + R+ + RN ++ Q+ +EM R++S + + SD +QD
Sbjct: 1330 LLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQD 1389
Query: 344 IIDSTPELDMCPETRLDRTGSSPTQGIVNKAFGIN-TDSLYHELSTAGSEVIGDVDEGAD 402
+ L+ + R + + TQ KA + + + L +++ D+D
Sbjct: 1390 FASTVEALEE-GKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQ 1448
Query: 403 LLGEFSGMGKEVGNLLLENSQL-----------------LETKNALNVVK--NDLIAKVD 443
L+ ++ LL E + ETK AL++ + + + +
Sbjct: 1449 LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETK-ALSLARALEEALEAKE 1507
Query: 444 QLSGEQEVLRGELEAAKQAKVKLENRIKELEEELKRVKSEAIIARREPKEEAEDVSSYL- 502
+L ++L+ E+E +K + + ELE+ + ++++ E K + E++ L
Sbjct: 1508 ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ----MEEMKTQLEELEDELQ 1563
Query: 503 CTESDKIPMAQRRRFTRVEMARVLM---ERNQYKERLMELQEAVRWTEMIRASREHPSVQ 559
TE K+ + + + + R L E+N+ K R ++ Q TE+ ++
Sbjct: 1564 ATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAA 1623
Query: 560 EKKK 563
KK
Sbjct: 1624 AAKK 1627
Score = 43.5 bits (101), Expect = 0.001
Identities = 101/538 (18%), Positives = 214/538 (39%), Gaps = 61/538 (11%)
Query: 49 EEVVKELMPLVVNVLENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKF 108
EE K + N+ + + + + E L+++ + L+ + ++ L E+K
Sbjct: 1398 EEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQ 1457
Query: 109 IEFEDALEQEKK---ELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALH 165
+F+ L +EK + + + E + R+ E KA + A + E + E+
Sbjct: 1458 RKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL-------- 1509
Query: 166 QRHTEMIQTYVEHIERSKMQQVGGN----SQTESSLPGRRKERPTSLNVFP-----LADG 216
+R +M++ +E + SK VG N +++ +L + +E T L D
Sbjct: 1510 ERTNKMLKAEMEDLVSSK-DDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDA 1568
Query: 217 TVRAQIGGKLVP--------AGDHWHLSDLGQLQSS-SSYQCPQDEMSESGQSSAAATPS 267
+R ++ + + A D + QLQ Y+ ++ + +AAA
Sbjct: 1569 KLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKK 1628
Query: 268 TTGTKSNTPTSSVPSAAVTPLNESLQPLGDYGVGSKNSKRAREKRDSRNMEVQVT---QE 324
G + + +A+ E+++ L K+ +R E + E+ T E
Sbjct: 1629 LEGDLKDLELQA--DSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENE 1686
Query: 325 MRNVSIGMGSSDEWSDVQDIIDSTPELDMCPETRLDRTGSSPTQGIVNKAFGINTDSLYH 384
+ S+ D+ + + D+ E + SS + + ++
Sbjct: 1687 KKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1746
Query: 385 ELSTAGSEVIGDVDEGADLLGEFSGMGKEVGN-LLLENSQLLETKNALNVVKNDLIAKVD 443
+L E G+++ +D + + + +++ N L E S + ++A
Sbjct: 1747 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQ----------- 1795
Query: 444 QLSGEQEVLRG---ELEAAKQAKVK-----LENRIKELEEELKRVKSEAIIARREPKEEA 495
QL + + LR E+E A ++K K LE +I +LEE++++ E A + K++
Sbjct: 1796 QLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKD 1855
Query: 496 EDVSSYLCTESDKIPMAQRRRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASR 553
+ + L D+ MA++ + E A + K+ +L+EA ++ I A+R
Sbjct: 1856 KKLKEILLQVEDERKMAEQYK----EQAE--KGNARVKQLKRQLEEAEEESQRINANR 1907
Score = 42.7 bits (99), Expect = 0.002
Identities = 33/137 (24%), Positives = 66/137 (48%), Gaps = 15/137 (10%)
Query: 61 NVLENLDSVLSENQEHEVEL-------ELLREDNEQLLTQYEREK----ALRRQAEEKFI 109
N +E++ +L+E + ++L +D ++LL + R+K RQ EE+
Sbjct: 1294 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1353
Query: 110 EFEDALEQE---KKELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQ 166
+D L++E K+ L+ + Q + K +++A + LEE + +KE L Q
Sbjct: 1354 SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ 1413
Query: 167 RHTEMIQTYVEHIERSK 183
++ E Y + +E++K
Sbjct: 1414 QYEEKAAAY-DKLEKTK 1429
Score = 38.9 bits (89), Expect = 0.033
Identities = 31/136 (22%), Positives = 60/136 (44%), Gaps = 11/136 (8%)
Query: 439 IAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELEE------ELKRVKSEAIIARREPK 492
+ +V + E + EL+ K+ + K EN +KELE+ E K + E + A E
Sbjct: 851 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 910
Query: 493 EEAEDVSSYLCTESDKIPMAQRRRFTRVEM-----ARVLMERNQYKERLMELQEAVRWTE 547
EAE++ L + ++ R+E ++ ER + +++++L+E + E
Sbjct: 911 AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEE 970
Query: 548 MIRASREHPSVQEKKK 563
R + V + K
Sbjct: 971 AARQKLQLEKVTAEAK 986
Score = 35.8 bits (81), Expect = 0.28
Identities = 26/127 (20%), Positives = 61/127 (48%), Gaps = 3/127 (2%)
Query: 48 DEEVVKELMPLVVNVLENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEK 107
+E+ K L ++ + E+L + ++ ++E E L E+ L+ + +R+ E +
Sbjct: 1685 NEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEAR 1744
Query: 108 FIEFEDALEQEKKELQIQVEHYEFQTRQLELKAKNYADQISRLEERES---EMKKEYNAL 164
+ E+ LE+E+ ++ + T+Q E + A + S ++ ES +++++ L
Sbjct: 1745 IAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKEL 1804
Query: 165 HQRHTEM 171
+ EM
Sbjct: 1805 RSKLHEM 1811
Score = 32.3 bits (72), Expect = 3.1
Identities = 27/141 (19%), Positives = 58/141 (41%), Gaps = 4/141 (2%)
Query: 27 ERVSGLAGSIYREFERLIHCYDEEVVKELMPLVVNVLENLDSVLSENQEHEVELELLRED 86
ER + S E E + + + L + + E ++ E Q L+ +
Sbjct: 1798 ERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKK 1857
Query: 87 NEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKELQIQVEHYEFQTRQLELKAKNYADQ 146
+++L Q E E+ + Q +E+ + K+L+ Q+E E +++++ + +
Sbjct: 1858 LKEILLQVEDERKMAEQYKEQ----AEKGNARVKQLKRQLEEAEEESQRINANRRKLQRE 1913
Query: 147 ISRLEERESEMKKEYNALHQR 167
+ E M +E NAL +
Sbjct: 1914 LDEATESNEAMGREVNALKSK 1934
Score = 31.6 bits (70), Expect = 5.3
Identities = 18/71 (25%), Positives = 40/71 (56%), Gaps = 4/71 (5%)
Query: 108 FIEFEDALEQEKKELQIQVEHYEFQ-TRQLELKAKNYADQISRLEERESEMKKEYNALHQ 166
F + + L+ ++E ++Q + E Q T++ + KA+N ++ LE++ S++ +E N L +
Sbjct: 845 FTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAEN---ELKELEQKHSQLTEEKNLLQE 901
Query: 167 RHTEMIQTYVE 177
+ + Y E
Sbjct: 902 QLQAETELYAE 912
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 58.9 bits (141), Expect = 3e-08
Identities = 97/478 (20%), Positives = 191/478 (39%), Gaps = 55/478 (11%)
Query: 76 HEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKELQIQVEHYEFQTRQ 135
HE+E L E++ Q ER+K ++ ++ E+ LE+E+ Q + +
Sbjct: 932 HEMEARLEEEEDRGQQLQAERKKMA-----QQMLDLEEQLEEEEAARQ----KLQLEKVT 982
Query: 136 LELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIERSKMQQVGGNSQTE- 194
E K K D+I ++++ +++ KE L +R +++ E E++K N
Sbjct: 983 AEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESM 1042
Query: 195 -SSLPGRRKERPTSLNVFPLADGTVRAQIGGKLVPAGD-HWHLSDLGQLQSSSSYQCPQD 252
S L R K+ S ++ ++ G A D H ++DL + Q +
Sbjct: 1043 ISELEVRLKKEEKSRQELE----KLKRKLEG---DASDFHEQIADLQAQIAELKMQLAKK 1095
Query: 253 EMSESGQSSAAATPSTTGTKSNTPTSSVPSAAVTPLNESLQPLGDYGVGSKNSKRAREKR 312
E E Q++ A K+N A+ + E + D + + AR K
Sbjct: 1096 E--EELQAALARLDDEIAQKNN---------ALKKIRELEGHISDLQEDLDSERAARNKA 1144
Query: 313 DSRNMEVQVTQEMRNVSIGMGSSDEWSDVQDIIDSTPELDMCPETRLDRTGSSPTQGIVN 372
+ + ++ E ++++D +DST E R R ++
Sbjct: 1145 EKQKRDLGEELEALK-----------TELEDTLDSTATQQ---ELRAKR---EQEVTVLK 1187
Query: 373 KAFGINTDSLYHELSTAGSEVIGDVDEGADLLGEF----SGMGKEVGNLLLENSQLLETK 428
KA T S ++ + V+E + L +F + + K L EN+ L
Sbjct: 1188 KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGEL 1247
Query: 429 NALNVVKNDLIAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELEEELKRVKSEAIIAR 488
L K ++ K +L + + L+ + ++A+ +L +++ +L+ E++ V A
Sbjct: 1248 RVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAE 1307
Query: 489 REPKEEAEDVSSYLCTESDKIPMAQRRRFTRVEMARVLM----ERNQYKERLMELQEA 542
+ + A+DV+S D + Q ++ ++ L ERN +++L E EA
Sbjct: 1308 GKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEA 1365
Score = 48.1 bits (113), Expect = 5e-05
Identities = 102/544 (18%), Positives = 213/544 (39%), Gaps = 62/544 (11%)
Query: 63 LENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKEL 122
L LD +++ ++ L L + E+A R +AE++ + + LE K EL
Sbjct: 1103 LARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTEL 1162
Query: 123 QIQVEHYEFQTRQLELKAKNYADQI---SRLEERESEMKKEYNALHQRHTEMIQTYVEHI 179
+ + + Q EL+AK + L+E + + + Q+H + ++ E +
Sbjct: 1163 E---DTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL 1219
Query: 180 ERSKMQQVGGNSQTESSLPGRRKERPTSLNVFPLADGTVRAQIGGKLVPAGDHWHLSDLG 239
E+ K + + + +L + L V G + ++ K + +
Sbjct: 1220 EQFKRAK-ANLDKNKQTLEKENADLAGELRVL----GQAKQEVEHKKKKLE-----AQVQ 1269
Query: 240 QLQSS-SSYQCPQDEMSESGQSSAAATPSTTGTKSNTPTSSVPSAA-VTPLNESLQPLGD 297
+LQS S + + E+++ S TG + ++ A V L+ LQ +
Sbjct: 1270 ELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQE 1329
Query: 298 YGVGSKNSK-----RAREKRDSRN-MEVQVTQEM-------RNVS-IGMGSSDEWSDVQD 343
K + R+ + RN ++ Q+ +EM R++S + + SD +QD
Sbjct: 1330 LLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQD 1389
Query: 344 IIDSTPELDMCPETRLDRTGSSPTQGIVNKAFGIN-TDSLYHELSTAGSEVIGDVDEGAD 402
+ L+ + R + + TQ KA + + + L +++ D+D
Sbjct: 1390 FASTVEALEE-GKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQ 1448
Query: 403 LLGEFSGMGKEVGNLLLENSQL-----------------LETKNALNVVK--NDLIAKVD 443
L+ ++ LL E + ETK AL++ + + + +
Sbjct: 1449 LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETK-ALSLARALEEALEAKE 1507
Query: 444 QLSGEQEVLRGELEAAKQAKVKLENRIKELEEELKRVKSEAIIARREPKEEAEDVSSYL- 502
+L ++L+ E+E +K + + ELE+ + ++++ E K + E++ L
Sbjct: 1508 ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ----MEEMKTQLEELEDELQ 1563
Query: 503 CTESDKIPMAQRRRFTRVEMARVLM---ERNQYKERLMELQEAVRWTEMIRASREHPSVQ 559
TE K+ + + + + R L E+N+ K R ++ Q TE+ ++
Sbjct: 1564 ATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAA 1623
Query: 560 EKKK 563
KK
Sbjct: 1624 AAKK 1627
Score = 43.5 bits (101), Expect = 0.001
Identities = 101/538 (18%), Positives = 214/538 (39%), Gaps = 61/538 (11%)
Query: 49 EEVVKELMPLVVNVLENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKF 108
EE K + N+ + + + + E L+++ + L+ + ++ L E+K
Sbjct: 1398 EEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQ 1457
Query: 109 IEFEDALEQEKK---ELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALH 165
+F+ L +EK + + + E + R+ E KA + A + E + E+
Sbjct: 1458 RKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL-------- 1509
Query: 166 QRHTEMIQTYVEHIERSKMQQVGGN----SQTESSLPGRRKERPTSLNVFP-----LADG 216
+R +M++ +E + SK VG N +++ +L + +E T L D
Sbjct: 1510 ERTNKMLKAEMEDLVSSK-DDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDA 1568
Query: 217 TVRAQIGGKLVP--------AGDHWHLSDLGQLQSS-SSYQCPQDEMSESGQSSAAATPS 267
+R ++ + + A D + QLQ Y+ ++ + +AAA
Sbjct: 1569 KLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKK 1628
Query: 268 TTGTKSNTPTSSVPSAAVTPLNESLQPLGDYGVGSKNSKRAREKRDSRNMEVQVT---QE 324
G + + +A+ E+++ L K+ +R E + E+ T E
Sbjct: 1629 LEGDLKDLELQA--DSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENE 1686
Query: 325 MRNVSIGMGSSDEWSDVQDIIDSTPELDMCPETRLDRTGSSPTQGIVNKAFGINTDSLYH 384
+ S+ D+ + + D+ E + SS + + ++
Sbjct: 1687 KKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1746
Query: 385 ELSTAGSEVIGDVDEGADLLGEFSGMGKEVGN-LLLENSQLLETKNALNVVKNDLIAKVD 443
+L E G+++ +D + + + +++ N L E S + ++A
Sbjct: 1747 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQ----------- 1795
Query: 444 QLSGEQEVLRG---ELEAAKQAKVK-----LENRIKELEEELKRVKSEAIIARREPKEEA 495
QL + + LR E+E A ++K K LE +I +LEE++++ E A + K++
Sbjct: 1796 QLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKD 1855
Query: 496 EDVSSYLCTESDKIPMAQRRRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASR 553
+ + L D+ MA++ + E A + K+ +L+EA ++ I A+R
Sbjct: 1856 KKLKEILLQVEDERKMAEQYK----EQAE--KGNARVKQLKRQLEEAEEESQRINANR 1907
Score = 42.7 bits (99), Expect = 0.002
Identities = 33/137 (24%), Positives = 66/137 (48%), Gaps = 15/137 (10%)
Query: 61 NVLENLDSVLSENQEHEVEL-------ELLREDNEQLLTQYEREK----ALRRQAEEKFI 109
N +E++ +L+E + ++L +D ++LL + R+K RQ EE+
Sbjct: 1294 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1353
Query: 110 EFEDALEQE---KKELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQ 166
+D L++E K+ L+ + Q + K +++A + LEE + +KE L Q
Sbjct: 1354 SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ 1413
Query: 167 RHTEMIQTYVEHIERSK 183
++ E Y + +E++K
Sbjct: 1414 QYEEKAAAY-DKLEKTK 1429
Score = 38.9 bits (89), Expect = 0.033
Identities = 31/136 (22%), Positives = 60/136 (44%), Gaps = 11/136 (8%)
Query: 439 IAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELEE------ELKRVKSEAIIARREPK 492
+ +V + E + EL+ K+ + K EN +KELE+ E K + E + A E
Sbjct: 851 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 910
Query: 493 EEAEDVSSYLCTESDKIPMAQRRRFTRVEM-----ARVLMERNQYKERLMELQEAVRWTE 547
EAE++ L + ++ R+E ++ ER + +++++L+E + E
Sbjct: 911 AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEE 970
Query: 548 MIRASREHPSVQEKKK 563
R + V + K
Sbjct: 971 AARQKLQLEKVTAEAK 986
Score = 35.8 bits (81), Expect = 0.28
Identities = 26/127 (20%), Positives = 61/127 (48%), Gaps = 3/127 (2%)
Query: 48 DEEVVKELMPLVVNVLENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEK 107
+E+ K L ++ + E+L + ++ ++E E L E+ L+ + +R+ E +
Sbjct: 1685 NEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEAR 1744
Query: 108 FIEFEDALEQEKKELQIQVEHYEFQTRQLELKAKNYADQISRLEERES---EMKKEYNAL 164
+ E+ LE+E+ ++ + T+Q E + A + S ++ ES +++++ L
Sbjct: 1745 IAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKEL 1804
Query: 165 HQRHTEM 171
+ EM
Sbjct: 1805 RSKLHEM 1811
Score = 32.3 bits (72), Expect = 3.1
Identities = 27/141 (19%), Positives = 58/141 (41%), Gaps = 4/141 (2%)
Query: 27 ERVSGLAGSIYREFERLIHCYDEEVVKELMPLVVNVLENLDSVLSENQEHEVELELLRED 86
ER + S E E + + + L + + E ++ E Q L+ +
Sbjct: 1798 ERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKK 1857
Query: 87 NEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKELQIQVEHYEFQTRQLELKAKNYADQ 146
+++L Q E E+ + Q +E+ + K+L+ Q+E E +++++ + +
Sbjct: 1858 LKEILLQVEDERKMAEQYKEQ----AEKGNARVKQLKRQLEEAEEESQRINANRRKLQRE 1913
Query: 147 ISRLEERESEMKKEYNALHQR 167
+ E M +E NAL +
Sbjct: 1914 LDEATESNEAMGREVNALKSK 1934
Score = 31.6 bits (70), Expect = 5.3
Identities = 18/71 (25%), Positives = 40/71 (56%), Gaps = 4/71 (5%)
Query: 108 FIEFEDALEQEKKELQIQVEHYEFQ-TRQLELKAKNYADQISRLEERESEMKKEYNALHQ 166
F + + L+ ++E ++Q + E Q T++ + KA+N ++ LE++ S++ +E N L +
Sbjct: 845 FTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAEN---ELKELEQKHSQLTEEKNLLQE 901
Query: 167 RHTEMIQTYVE 177
+ + Y E
Sbjct: 902 QLQAETELYAE 912
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 58.9 bits (141), Expect = 3e-08
Identities = 97/478 (20%), Positives = 191/478 (39%), Gaps = 55/478 (11%)
Query: 76 HEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKELQIQVEHYEFQTRQ 135
HE+E L E++ Q ER+K ++ ++ E+ LE+E+ Q + +
Sbjct: 925 HEMEARLEEEEDRGQQLQAERKKMA-----QQMLDLEEQLEEEEAARQ----KLQLEKVT 975
Query: 136 LELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIERSKMQQVGGNSQTE- 194
E K K D+I ++++ +++ KE L +R +++ E E++K N
Sbjct: 976 AEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESM 1035
Query: 195 -SSLPGRRKERPTSLNVFPLADGTVRAQIGGKLVPAGD-HWHLSDLGQLQSSSSYQCPQD 252
S L R K+ S ++ ++ G A D H ++DL + Q +
Sbjct: 1036 ISELEVRLKKEEKSRQELE----KLKRKLEG---DASDFHEQIADLQAQIAELKMQLAKK 1088
Query: 253 EMSESGQSSAAATPSTTGTKSNTPTSSVPSAAVTPLNESLQPLGDYGVGSKNSKRAREKR 312
E E Q++ A K+N A+ + E + D + + AR K
Sbjct: 1089 E--EELQAALARLDDEIAQKNN---------ALKKIRELEGHISDLQEDLDSERAARNKA 1137
Query: 313 DSRNMEVQVTQEMRNVSIGMGSSDEWSDVQDIIDSTPELDMCPETRLDRTGSSPTQGIVN 372
+ + ++ E ++++D +DST E R R ++
Sbjct: 1138 EKQKRDLGEELEALK-----------TELEDTLDSTATQQ---ELRAKR---EQEVTVLK 1180
Query: 373 KAFGINTDSLYHELSTAGSEVIGDVDEGADLLGEF----SGMGKEVGNLLLENSQLLETK 428
KA T S ++ + V+E + L +F + + K L EN+ L
Sbjct: 1181 KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGEL 1240
Query: 429 NALNVVKNDLIAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELEEELKRVKSEAIIAR 488
L K ++ K +L + + L+ + ++A+ +L +++ +L+ E++ V A
Sbjct: 1241 RVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAE 1300
Query: 489 REPKEEAEDVSSYLCTESDKIPMAQRRRFTRVEMARVLM----ERNQYKERLMELQEA 542
+ + A+DV+S D + Q ++ ++ L ERN +++L E EA
Sbjct: 1301 GKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEA 1358
Score = 48.1 bits (113), Expect = 5e-05
Identities = 102/544 (18%), Positives = 213/544 (39%), Gaps = 62/544 (11%)
Query: 63 LENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKEL 122
L LD +++ ++ L L + E+A R +AE++ + + LE K EL
Sbjct: 1096 LARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTEL 1155
Query: 123 QIQVEHYEFQTRQLELKAKNYADQI---SRLEERESEMKKEYNALHQRHTEMIQTYVEHI 179
+ + + Q EL+AK + L+E + + + Q+H + ++ E +
Sbjct: 1156 E---DTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL 1212
Query: 180 ERSKMQQVGGNSQTESSLPGRRKERPTSLNVFPLADGTVRAQIGGKLVPAGDHWHLSDLG 239
E+ K + + + +L + L V G + ++ K + +
Sbjct: 1213 EQFKRAK-ANLDKNKQTLEKENADLAGELRVL----GQAKQEVEHKKKKLE-----AQVQ 1262
Query: 240 QLQSS-SSYQCPQDEMSESGQSSAAATPSTTGTKSNTPTSSVPSAA-VTPLNESLQPLGD 297
+LQS S + + E+++ S TG + ++ A V L+ LQ +
Sbjct: 1263 ELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQE 1322
Query: 298 YGVGSKNSK-----RAREKRDSRN-MEVQVTQEM-------RNVS-IGMGSSDEWSDVQD 343
K + R+ + RN ++ Q+ +EM R++S + + SD +QD
Sbjct: 1323 LLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQD 1382
Query: 344 IIDSTPELDMCPETRLDRTGSSPTQGIVNKAFGIN-TDSLYHELSTAGSEVIGDVDEGAD 402
+ L+ + R + + TQ KA + + + L +++ D+D
Sbjct: 1383 FASTVEALEE-GKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQ 1441
Query: 403 LLGEFSGMGKEVGNLLLENSQL-----------------LETKNALNVVK--NDLIAKVD 443
L+ ++ LL E + ETK AL++ + + + +
Sbjct: 1442 LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETK-ALSLARALEEALEAKE 1500
Query: 444 QLSGEQEVLRGELEAAKQAKVKLENRIKELEEELKRVKSEAIIARREPKEEAEDVSSYL- 502
+L ++L+ E+E +K + + ELE+ + ++++ E K + E++ L
Sbjct: 1501 ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ----MEEMKTQLEELEDELQ 1556
Query: 503 CTESDKIPMAQRRRFTRVEMARVLM---ERNQYKERLMELQEAVRWTEMIRASREHPSVQ 559
TE K+ + + + + R L E+N+ K R ++ Q TE+ ++
Sbjct: 1557 ATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAA 1616
Query: 560 EKKK 563
KK
Sbjct: 1617 AAKK 1620
Score = 43.5 bits (101), Expect = 0.001
Identities = 101/538 (18%), Positives = 214/538 (39%), Gaps = 61/538 (11%)
Query: 49 EEVVKELMPLVVNVLENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKF 108
EE K + N+ + + + + E L+++ + L+ + ++ L E+K
Sbjct: 1391 EEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQ 1450
Query: 109 IEFEDALEQEKK---ELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALH 165
+F+ L +EK + + + E + R+ E KA + A + E + E+
Sbjct: 1451 RKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL-------- 1502
Query: 166 QRHTEMIQTYVEHIERSKMQQVGGN----SQTESSLPGRRKERPTSLNVFP-----LADG 216
+R +M++ +E + SK VG N +++ +L + +E T L D
Sbjct: 1503 ERTNKMLKAEMEDLVSSK-DDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDA 1561
Query: 217 TVRAQIGGKLVP--------AGDHWHLSDLGQLQSS-SSYQCPQDEMSESGQSSAAATPS 267
+R ++ + + A D + QLQ Y+ ++ + +AAA
Sbjct: 1562 KLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKK 1621
Query: 268 TTGTKSNTPTSSVPSAAVTPLNESLQPLGDYGVGSKNSKRAREKRDSRNMEVQVT---QE 324
G + + +A+ E+++ L K+ +R E + E+ T E
Sbjct: 1622 LEGDLKDLELQA--DSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENE 1679
Query: 325 MRNVSIGMGSSDEWSDVQDIIDSTPELDMCPETRLDRTGSSPTQGIVNKAFGINTDSLYH 384
+ S+ D+ + + D+ E + SS + + ++
Sbjct: 1680 KKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1739
Query: 385 ELSTAGSEVIGDVDEGADLLGEFSGMGKEVGN-LLLENSQLLETKNALNVVKNDLIAKVD 443
+L E G+++ +D + + + +++ N L E S + ++A
Sbjct: 1740 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQ----------- 1788
Query: 444 QLSGEQEVLRG---ELEAAKQAKVK-----LENRIKELEEELKRVKSEAIIARREPKEEA 495
QL + + LR E+E A ++K K LE +I +LEE++++ E A + K++
Sbjct: 1789 QLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKD 1848
Query: 496 EDVSSYLCTESDKIPMAQRRRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASR 553
+ + L D+ MA++ + E A + K+ +L+EA ++ I A+R
Sbjct: 1849 KKLKEILLQVEDERKMAEQYK----EQAE--KGNARVKQLKRQLEEAEEESQRINANR 1900
Score = 42.7 bits (99), Expect = 0.002
Identities = 33/137 (24%), Positives = 66/137 (48%), Gaps = 15/137 (10%)
Query: 61 NVLENLDSVLSENQEHEVEL-------ELLREDNEQLLTQYEREK----ALRRQAEEKFI 109
N +E++ +L+E + ++L +D ++LL + R+K RQ EE+
Sbjct: 1287 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1346
Query: 110 EFEDALEQE---KKELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQ 166
+D L++E K+ L+ + Q + K +++A + LEE + +KE L Q
Sbjct: 1347 SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ 1406
Query: 167 RHTEMIQTYVEHIERSK 183
++ E Y + +E++K
Sbjct: 1407 QYEEKAAAY-DKLEKTK 1422
Score = 38.9 bits (89), Expect = 0.033
Identities = 31/136 (22%), Positives = 60/136 (44%), Gaps = 11/136 (8%)
Query: 439 IAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELEE------ELKRVKSEAIIARREPK 492
+ +V + E + EL+ K+ + K EN +KELE+ E K + E + A E
Sbjct: 844 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 903
Query: 493 EEAEDVSSYLCTESDKIPMAQRRRFTRVEM-----ARVLMERNQYKERLMELQEAVRWTE 547
EAE++ L + ++ R+E ++ ER + +++++L+E + E
Sbjct: 904 AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEE 963
Query: 548 MIRASREHPSVQEKKK 563
R + V + K
Sbjct: 964 AARQKLQLEKVTAEAK 979
Score = 35.8 bits (81), Expect = 0.28
Identities = 26/127 (20%), Positives = 61/127 (48%), Gaps = 3/127 (2%)
Query: 48 DEEVVKELMPLVVNVLENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEK 107
+E+ K L ++ + E+L + ++ ++E E L E+ L+ + +R+ E +
Sbjct: 1678 NEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEAR 1737
Query: 108 FIEFEDALEQEKKELQIQVEHYEFQTRQLELKAKNYADQISRLEERES---EMKKEYNAL 164
+ E+ LE+E+ ++ + T+Q E + A + S ++ ES +++++ L
Sbjct: 1738 IAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKEL 1797
Query: 165 HQRHTEM 171
+ EM
Sbjct: 1798 RSKLHEM 1804
Score = 32.3 bits (72), Expect = 3.1
Identities = 27/141 (19%), Positives = 58/141 (41%), Gaps = 4/141 (2%)
Query: 27 ERVSGLAGSIYREFERLIHCYDEEVVKELMPLVVNVLENLDSVLSENQEHEVELELLRED 86
ER + S E E + + + L + + E ++ E Q L+ +
Sbjct: 1791 ERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKK 1850
Query: 87 NEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKELQIQVEHYEFQTRQLELKAKNYADQ 146
+++L Q E E+ + Q +E+ + K+L+ Q+E E +++++ + +
Sbjct: 1851 LKEILLQVEDERKMAEQYKEQ----AEKGNARVKQLKRQLEEAEEESQRINANRRKLQRE 1906
Query: 147 ISRLEERESEMKKEYNALHQR 167
+ E M +E NAL +
Sbjct: 1907 LDEATESNEAMGREVNALKSK 1927
Score = 31.6 bits (70), Expect = 5.3
Identities = 18/71 (25%), Positives = 40/71 (56%), Gaps = 4/71 (5%)
Query: 108 FIEFEDALEQEKKELQIQVEHYEFQ-TRQLELKAKNYADQISRLEERESEMKKEYNALHQ 166
F + + L+ ++E ++Q + E Q T++ + KA+N ++ LE++ S++ +E N L +
Sbjct: 838 FTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAEN---ELKELEQKHSQLTEEKNLLQE 894
Query: 167 RHTEMIQTYVE 177
+ + Y E
Sbjct: 895 QLQAETELYAE 905
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 58.9 bits (141), Expect = 3e-08
Identities = 98/536 (18%), Positives = 219/536 (40%), Gaps = 46/536 (8%)
Query: 49 EEVVKELMPLVVNVLENLDSVLSENQEHEVELELLREDNEQLLTQYER----EKALRRQA 104
E++VKE+ L + + +++E + E E+L + E + + ER +A+R++
Sbjct: 1584 EKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEK 1643
Query: 105 EEKFIEFEDALEQEKKELQIQVEHYEFQTRQLELKAKNYA----DQISRLEERESEMKKE 160
+E + + E KKE + Q++ E + +++ K + +A +I LEE ++ E
Sbjct: 1644 QELYGKLRST-EANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAE 1702
Query: 161 YNALHQRHTEMIQTYV-------EHIERSKMQQVGGNSQTESSLPGRRKERPTSLNVFPL 213
+ E ++T + E +ER KM+ + + +S + + ++
Sbjct: 1703 VHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQ 1762
Query: 214 ADGTVRAQIGGKLVPAGDHWHLSDLGQLQSSSSYQCPQDEMSESGQSSAAATPSTTGTKS 273
+G V Q L H + +++ + + S +++ S S + + S KS
Sbjct: 1763 IEGNVSKQ--ANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKS 1820
Query: 274 NTPTSSVPSAAVTPLNESLQPLGDY--GVGSKNSKRAREKRDSRNMEVQVTQEMRNVSIG 331
P S ++ +N LQ + + ++ + K S+ +E + + +S
Sbjct: 1821 ANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTK 1880
Query: 332 MGS---SDEWSDVQDIIDSTPELDMCPETRLDRTGSSPTQGIVNKAFGINTDSLYHELST 388
G E ++++ + ++ T+L T + + L +
Sbjct: 1881 DGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMN-QLAELNGSIGN 1939
Query: 389 AGSEVIGDVDEGADLLGEFSGMGKEVGNLLLENSQLLETKNAL-NVVKNDLIAKVDQLSG 447
+V + L E + K V L E QL++ K + + ++ + + K+
Sbjct: 1940 YCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQK 1999
Query: 448 E----------QEVLRGELEAAKQAK---VKLENRIKELEEELKRVKSEAIIARREPKEE 494
E QE+L+ + + KQ + ++ + +I LE +K ++ ++++ +
Sbjct: 2000 EPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEIT 2059
Query: 495 AEDVSSYLCTESDKIPMAQRRRF------TRVEMARVLMERNQYKERLMELQEAVR 544
E+++ E K A+ F T+ E ARVL + + K+ L +E+V+
Sbjct: 2060 KENLAQ--AVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVK 2113
Score = 48.1 bits (113), Expect = 5e-05
Identities = 109/551 (19%), Positives = 210/551 (38%), Gaps = 78/551 (14%)
Query: 63 LEN-LDSVLSENQEHEVELELLRED-------NEQLLTQYEREKALRRQAEEKFIEFEDA 114
LEN +++LS+ + EL++L+E+ N+Q+ + R L+ AEE+ + E+
Sbjct: 1866 LENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEER 1925
Query: 115 LEQEKKELQIQVEHY-------EFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQR 167
L + EL + +Y + + LE + KN +S LEE + ++ KE +
Sbjct: 1926 LMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVE-- 1983
Query: 168 HTEMIQTYVEHIERSKMQQVGGNSQTESSLPGRRKERPTSLNVFPLADGTVRAQIGGKLV 227
+E+ + Y+E I+ + Q+ GN L KE+ + L +R Q K+
Sbjct: 1984 -SEIRKEYLEKIQGA--QKEPGNKSHAKELQELLKEKQQEVK--QLQKDCIRYQ--EKIS 2036
Query: 228 PAGDHWHLSDLGQLQSSSSYQCPQDEMSESGQSSAAATPSTTGTKSNTPTSSVPSAAVTP 287
+ Q +S + ++ ++++ + A K + +A V
Sbjct: 2037 ALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLA 2096
Query: 288 LNESLQPLGDYGVGS------------------------KNSKRAREKRDS-RNMEVQVT 322
N L+ S K K +EK D+ R +V +
Sbjct: 2097 DNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLE 2156
Query: 323 QEMRNVSIGMGSSD-EWSDVQDIIDSTPELDMCPETRLDRTGSSPTQGIVNKAFGINTDS 381
+ + + + + D E +Q+ +DST + T+ + ++++A
Sbjct: 2157 ETIGEIQVTLNKKDKEVQQLQENLDSTVT-QLAAFTKSMSSLQDDRDRVIDEAKKWER-K 2214
Query: 382 LYHELSTAGSEVIGDVDEGADLLGEFSGMGKEVGNL------LLENSQLLETKNALNVVK 435
+ + E+ D + L + M + L L + Q+ E+K V
Sbjct: 2215 FSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQL 2274
Query: 436 NDLIAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELEEELKRVKSEAIIARREPKEEA 495
+ D L GE + L +LE + +N + +LE ELK + K++
Sbjct: 2275 QQKVC--DTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSL-----------KDQL 2321
Query: 496 EDVSSYLCTESDKIPMAQRRRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASREH 555
D+S+ L E K R + A + + Y++ +LQ + T SR H
Sbjct: 2322 TDLSNSL--EKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELT-----SRLH 2374
Query: 556 PSVQEKKKSTI 566
+ K++ I
Sbjct: 2375 EEINMKEQKII 2385
Score = 41.2 bits (95), Expect = 0.007
Identities = 39/170 (22%), Positives = 80/170 (47%), Gaps = 18/170 (10%)
Query: 40 FERLIHCYDEEVVKELMPLVVNV-----LENLDSVLSENQEHEVELELLREDNEQLLTQY 94
FE + +++E+++ + V L L L E++E V + + +Q LT
Sbjct: 226 FETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAA 285
Query: 95 E-REKALRRQAEEKFIE---FEDALEQEKKELQIQVEHYEFQTRQLELKAKNYADQISRL 150
E R + L +Q ++ E + +E E++E +I +E E + + +L N +++ L
Sbjct: 286 EQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHL 345
Query: 151 EER-------ESEMKKEYNALHQRHTEMIQTYVEHIERSKMQQVGGNSQT 193
E+ ++E++ Y+AL Q+H ++ HI +Q+ G Q+
Sbjct: 346 LEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHI--LSLQKTGQELQS 393
Score = 40.4 bits (93), Expect = 0.011
Identities = 126/637 (19%), Positives = 227/637 (35%), Gaps = 124/637 (19%)
Query: 50 EVVKELMPLVVNVLENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKFI 109
E+ + +V + E S+ E + + +L LL E Q E + + ++ +
Sbjct: 905 EISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYD 964
Query: 110 EFEDALEQEKKELQIQVE--HYEFQTRQLELKA-----KNYADQISRLEER----ESEMK 158
E A + K+ELQ + + E + R+ +L+A K ++SRLEE + E K
Sbjct: 965 EMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESK 1024
Query: 159 KEYNALHQRHTEMIQ-----TYVEHIERSKMQQV-----GGNSQTESSLPGRRKERPTSL 208
KE E+ + Y E SK Q++ S+ E L RK+ L
Sbjct: 1025 KEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKL 1084
Query: 209 NVFPLADGTVRAQIGGKLVPAGDHWHLSDLGQLQSSSSYQCPQDEMSESGQSS------- 261
A+ +A + D + DL Q + S + Q ++ + +S
Sbjct: 1085 ----AAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVAL 1140
Query: 262 ----AAATPSTTGTKSN-TPTSSVPSAAVTPLNESLQPLGDYGVGSKNS--KRAREK--- 311
+P TG+ + P A+ E LQ + S+ + K+A+EK
Sbjct: 1141 VKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERH 1200
Query: 312 -----------------------RDSRNMEVQVTQEMRNVSIGMGSSDEWSDVQDIIDST 348
+++ N+ Q+ Q V + +D Q+ ST
Sbjct: 1201 LREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSST 1260
Query: 349 P-------------------ELDMCPETRLDRTGSSPTQGIVN--------KAFGINTDS 381
P E ++CP+ +S QG + K
Sbjct: 1261 PGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVE 1320
Query: 382 LYHELSTAGSEVIGDVDEGADLLGEFSGMGKEVGNL----------------LLENSQL- 424
L ++S+ SE+ +E L + + G E+ +L LE+SQL
Sbjct: 1321 LELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQ 1380
Query: 425 ---LETKNALNVVKNDLIAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELEEELKRVK 481
LE L ++L + + + L G+L + A K++ I E E+ +K +
Sbjct: 1381 IAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALH 1440
Query: 482 SEAIIARREPKEEAEDVSSYLCTESDKIPMAQRRRFTRVEMAR----VLMERNQYKERLM 537
++ + +E E + + LC K + ++ R L+ R + +
Sbjct: 1441 TQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENK 1500
Query: 538 ELQEAV--------RWTEMIRASREHPSVQEKKKSTI 566
LQE + R T+ + S Q K+K T+
Sbjct: 1501 SLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTV 1537
Score = 37.4 bits (85), Expect = 0.097
Identities = 24/107 (22%), Positives = 51/107 (47%), Gaps = 24/107 (22%)
Query: 65 NLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKELQI 124
++D + SEN + + EL RED Q++T +D+ +++ E+Q+
Sbjct: 2518 HMDDLNSENAKLDAELIQYREDLNQVIT------------------IKDSQQKQLLEVQL 2559
Query: 125 QVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQRHTEM 171
Q Q ++LE K +++ EE ++++ +NAL + ++
Sbjct: 2560 Q------QNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDL 2600
Score = 36.6 bits (83), Expect = 0.16
Identities = 97/498 (19%), Positives = 200/498 (40%), Gaps = 94/498 (18%)
Query: 59 VVNVLENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQE 118
V + ENLDS +++ + L++D ++++ + ++ + +F DA++ +
Sbjct: 2173 VQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWER----------KFSDAIQSK 2222
Query: 119 KKELQIQVEHYEF---QTRQLELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTY 175
++E++++ ++ Q RQ+ + + ISRLE K+ + + Q ++ Q
Sbjct: 2223 EEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHD----KQIWESKAQTEVQLQQKV 2278
Query: 176 VEHIERSKMQQVGGNSQTESSLPGRRKERPTSLNVFPLADGTVRAQIGGKLVPAGDHWHL 235
+ ++ G N + S L R +S N A++ +L D L
Sbjct: 2279 CDTLQ-------GENKELLSQLEETRHLYHSSQNEL--------AKLESELKSLKD--QL 2321
Query: 236 SDLGQLQSSSSYQCPQDEMSESG--QSSAAATPSTTGTKSNTPTSSVPSAAVTP-LNESL 292
+DL S+S +C + + + G + A ++ + T S +T L+E +
Sbjct: 2322 TDL----SNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEI 2377
Query: 293 QPLGDYGVGSKNSKRAREKRDSRNMEVQVTQEMRNVSIGMGSSDEWSDV-----QDIIDS 347
+ + K + + Q +E++ + + +E + V + +D
Sbjct: 2378 NMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDK 2437
Query: 348 TPELDMCPETRLDRTGSSPTQGIVNKAFGINTDSLYHELSTAGSEVIGDVDEGADLLGEF 407
T +L ++ + + I KA DS +S+ + D D ++G++
Sbjct: 2438 TNQL-------METLKTIKKENIQQKA---QLDSFVKSMSS----LQNDRDR---IVGDY 2480
Query: 408 SGMGKEVGNLLLENSQLLE----TKNALNVVKNDLIAKVDQLSGEQEVLRGE-------- 455
+ + +++LE QL++ N L L + +D L+ E L E
Sbjct: 2481 QQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDL 2540
Query: 456 --------------LEAAKQAKVKLENRIKELEEELKRVKSEAIIARRE---PKEEAEDV 498
LE Q +LEN+ +LEE+LK + RR +EE +D+
Sbjct: 2541 NQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDL 2600
Query: 499 SSYLCTESDKIPMAQRRR 516
S + ES K+ ++Q R
Sbjct: 2601 SKEI--ESLKVSISQLTR 2616
Score = 36.2 bits (82), Expect = 0.22
Identities = 32/166 (19%), Positives = 71/166 (42%), Gaps = 1/166 (0%)
Query: 380 DSLYHELSTAGSEVIGDVDEGADLLGEFSGMGKEVGNLLLENSQLLETKNALNVVKNDLI 439
+ L L+ S+V E +LG + + +E L+ E + L +L+ L
Sbjct: 1514 ERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLK 1573
Query: 440 AKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELEEELKRVKSEAIIARREPKEEAEDVS 499
++ L+ ++E L E+E+ K +K+ +E +EL++ + + EAE +
Sbjct: 1574 LALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQ 1633
Query: 500 SYL-CTESDKIPMAQRRRFTRVEMARVLMERNQYKERLMELQEAVR 544
+ +K + + R T + + ++ + E++E +R
Sbjct: 1634 HVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMR 1679
Score = 34.7 bits (78), Expect = 0.63
Identities = 107/547 (19%), Positives = 213/547 (38%), Gaps = 85/547 (15%)
Query: 64 ENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEE------KFIEFEDALEQ 117
E+L L +Q LE LRE +L E +K + ++ E+ + E E AL +
Sbjct: 1368 ESLQQKLESSQLQIAGLEHLRELQPKL---DELQKLISKKEEDVSYLSGQLSEKEAALTK 1424
Query: 118 EKKELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNAL--HQRHTEMIQTY 175
+ E+ Q + + QLE++AK + ++I +L+ EMK++ + R + IQ
Sbjct: 1425 IQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRK 1484
Query: 176 VEHIERSKMQQVGGN---------------------SQTESSLPGRRKERPTSLNVFPLA 214
++ S+ + + N + ES + + KE+ T L L
Sbjct: 1485 LQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALL 1544
Query: 215 DGTVRAQIGGKLVPAGDHWHLSDLGQLQSSSSYQCPQDEMSESGQSSAAATPSTTGTKSN 274
+ KL+ D L + S S + + ++E + S +K
Sbjct: 1545 Q-----EERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSK-- 1597
Query: 275 TPTSSVPSAAVTPLNESLQPL-GDYGVGSKNSKRAREKRDSRNMEVQVTQEMRNVSIGMG 333
A T E + L +Y + ++ + + + V+ ++ + G
Sbjct: 1598 -------IAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKL 1650
Query: 334 SSDEWSDVQ---DIIDSTPELDMCPETRLDRTGSSPTQGIVNKAFGINTDSLYHELSTAG 390
S E + + + ++ E++ E ++ + S Q I+ D L E+ AG
Sbjct: 1651 RSTEANKKETEKQLQEAEQEMEEMKE-KMRKFAKSKQQKILE--LEEENDRLRAEVHPAG 1707
Query: 391 SEVIGDVDEGADLLGEFSGMGKEVGNLLLENSQLLETKNALNVVKNDLIAKVDQLSGEQE 450
++ LL + M +E+ + +E L + + L+++ D LS E +
Sbjct: 1708 DTAKECME---TLLSSNASMKEELERVKMEYETLSKKFQS-------LMSEKDSLSEEVQ 1757
Query: 451 VLRGELE--AAKQAKV----KLENRIKELEEELKRVKSEAIIARREPKEEAEDVSSYLCT 504
L+ ++E +KQA + K +N+ EE + + E E ++ + C+
Sbjct: 1758 DLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGET-----EEQDSLSMSTRPTCS 1812
Query: 505 ES-----DKIPMAQRRRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASREHPSVQ 559
ES P + + E+ L + +Q KER+ L+E + ++E
Sbjct: 1813 ESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEK------QKNKEFSQTL 1866
Query: 560 EKKKSTI 566
E +K+T+
Sbjct: 1867 ENEKNTL 1873
Score = 32.3 bits (72), Expect = 3.1
Identities = 30/126 (23%), Positives = 60/126 (47%), Gaps = 8/126 (6%)
Query: 420 ENSQLLETKNALNVVKNDLIAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELEEELK- 478
E S++L K L V + L L E L + E A QA+ +LE+R LE++ K
Sbjct: 315 EESKILLEKMELEVAERKL--SFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKA 372
Query: 479 --RVKSEAIIARREPKEEAEDVSSYLCTESDKIPMAQRRRFTRVEMARVLME-RNQYKER 535
K+ I++ ++ +E + L ++ K + Q + V+ A+ + + +Q +++
Sbjct: 373 EMEEKTSHILSLQKTGQELQSACDALKDQNSK--LLQDKNEQAVQSAQTIQQLEDQLQQK 430
Query: 536 LMELQE 541
E+ +
Sbjct: 431 SKEISQ 436
Score = 31.6 bits (70), Expect = 5.3
Identities = 29/163 (17%), Positives = 68/163 (41%), Gaps = 29/163 (17%)
Query: 54 ELMPLVVNVLENLDSVLSENQEHEVELE-----LLREDNEQLLTQYEREKALRRQAEEKF 108
E + + ++ LE+ + + EV+L+ L+ +N++LL+Q E + L ++ +
Sbjct: 2248 EELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNEL 2307
Query: 109 IEFEDALEQEKKEL------------------------QIQVEHYEFQTRQLELKAKNYA 144
+ E L+ K +L + +++ +F QLE +
Sbjct: 2308 AKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASR 2367
Query: 145 DQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIERSKMQQV 187
+ SRL E + +++ +L E IQ + + + +++
Sbjct: 2368 ELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEI 2410
Score = 31.2 bits (69), Expect = 6.9
Identities = 27/110 (24%), Positives = 52/110 (47%), Gaps = 13/110 (11%)
Query: 45 HCYDEEVVKELMPLVVNVLENLDSVLSENQEHEVELELLREDNEQLLTQYER-EKALRRQ 103
+C D + L+ + ++NL +SE L E+ +QL+ + + E +R++
Sbjct: 1940 YCQDVTDAQIKNELLESEMKNLKKCVSE----------LEEEKQQLVKEKTKVESEIRKE 1989
Query: 104 AEEKF--IEFEDALEQEKKELQIQVEHYEFQTRQLELKAKNYADQISRLE 151
EK + E + KELQ ++ + + +QL+ Y ++IS LE
Sbjct: 1990 YLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALE 2039
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 53.9 bits (128), Expect = 1e-06
Identities = 103/533 (19%), Positives = 216/533 (40%), Gaps = 46/533 (8%)
Query: 49 EEVVKELMPLVVNVLENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKF 108
E ++E ++ + + L + QE E E + ++E+ E L Q E KA E++
Sbjct: 1935 ERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQL 1994
Query: 109 IEFEDALEQEKKELQIQVE----HYEFQTRQLELKAKNYADQISRLEERESEMKKEYNAL 164
++ + L +EK E+Q Q E + Q + LE+ + +Q+SR E E E E L
Sbjct: 1995 LQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVE---EQVSRFIELEQEKNTELMDL 2051
Query: 165 HQRHTEMIQTYVEHIERSKMQQVGGNSQTESSLPGRRKERPTSLNVF----PLADGTVR- 219
Q++ + ++ +E + + +Q ++ L V P+++ R
Sbjct: 2052 RQQN-QALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTRE 2110
Query: 220 -AQIGGKLVPAGDHWHLSDLGQLQSSSSYQCPQDEMS-------ESGQSSAAATPSTTGT 271
Q+ L D L + Q Q +E+ E Q+ + +
Sbjct: 2111 VEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKV 2170
Query: 272 KSNTPTSSVPSAAVTPLNESLQPLGDYGVGSKNSKRAREKRDSRNMEVQVTQ---EMRNV 328
+ +V + L LQ ++ R++++ N+E Q+ Q E+ N
Sbjct: 2171 EDRKHFGAVEAKPELSLEVQLQ--------AERDAIDRKEKEITNLEEQLEQFREELENK 2222
Query: 329 SIGMGSSDEWSDVQDIIDSTPELDMCPETRLDRTGSSPTQGIVNKAFGINTDSLYHELST 388
+ + ++Q +T ++ E +L + + ++ ++T H L
Sbjct: 2223 NEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQD-QHVLFG 2281
Query: 389 AGSEVIGDVDEGADLLGEFSGMGKEVGNLLLENSQLLETKNALNVVKNDLIAKVDQLSGE 448
+++I + + D L E ++ + +N +++E KN L DL +++ L +
Sbjct: 2282 KFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDN-KVIEEKNEL---IRDLETQIECLMSD 2337
Query: 449 QEVLRGELEAAKQAKVKLENRIKELEEELKRVKSEAIIARREPKEEAEDVSSYL-CTESD 507
QE ++ E + +L I++L++EL + + + EEA+ + L ++
Sbjct: 2338 QECVKRNREEEIE---QLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAE 2394
Query: 508 KIPMAQRRRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASREHPSVQE 560
K+ + Q+ EM +N KE ++ + + E+ RE SV++
Sbjct: 2395 KLALEQQVETANEEMT---FMKNVLKETNFKMNQLTQ--ELFSLKRERESVEK 2442
Score = 40.4 bits (93), Expect = 0.011
Identities = 37/152 (24%), Positives = 72/152 (47%), Gaps = 22/152 (14%)
Query: 27 ERVSGLAGSIYREFERLIHCYDEEVVKE-LMPLVVNVLENLDSVLSENQEHEVELELLRE 85
+++ GL + ++ E + D + K+ + L ++ L++L L ++ E+ L++
Sbjct: 665 QQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINEL 724
Query: 86 DNE-QLLTQYEREKALRRQAEEKFIEFEDALEQEKKELQIQVEHYEFQTRQLELKAKNYA 144
E ++L Q E+EK LEQE +ELQ++ E E +Q++ K +
Sbjct: 725 QKEIEILRQEEKEKG--------------TLEQEVQELQLKTELLE---KQMKEKENDLQ 767
Query: 145 DQISRLEERESEMKKEYNALHQR---HTEMIQ 173
++ ++LE S +K E L HT + Q
Sbjct: 768 EKFAQLEAENSILKDEKKTLEDMLKIHTPVSQ 799
Score = 38.5 bits (88), Expect = 0.043
Identities = 33/156 (21%), Positives = 70/156 (44%), Gaps = 22/156 (14%)
Query: 405 GEFSGMGKEVGNLLLENSQLLETKNALNVVKNDLIAKVDQLSGEQEVLRGELEAAKQAKV 464
GE + N+ + Q+ +NV N+L K+ + ++E L+ EL + K
Sbjct: 469 GEMENALRSYSNITVNEDQI----KLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKC 524
Query: 465 KLENRIKELEEELKRVKSEAIIARREPKEE-------------AEDVSSYLCTESD---K 508
L+ ++++L EEL + + AR+ E+ ED+ + + + S+ +
Sbjct: 525 ALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKE 584
Query: 509 IPMAQRRRFT--RVEMARVLMERNQYKERLMELQEA 542
+ + T ++++ + E+N +R+ E QEA
Sbjct: 585 LELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEA 620
Score = 36.6 bits (83), Expect = 0.16
Identities = 104/525 (19%), Positives = 193/525 (36%), Gaps = 109/525 (20%)
Query: 49 EEVVKELMPLVVNVLENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKF 108
E++ +EL+ N + +L LS+ ++H E + + L+ E+E Q +K
Sbjct: 2713 EKLQEELLVKETN-MTSLQKDLSQVRDHLAEAK-------EKLSILEKEDETEVQESKKA 2764
Query: 109 IEFEDALEQEKKELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQRH 168
FE + K + Q + L++ + N QI ++ ++ + +
Sbjct: 2765 CMFEPLPIKLSKSIASQTDG------TLKISSSNQTPQIL-VKNAGIQINLQSECSSEEV 2817
Query: 169 TEMIQTYVEHIERSKMQQVGG------NSQTESSLPGRRKERPTSLNVFPLADGTVRAQI 222
TE+I + E IE KMQ++ S+ S ++E ++ + GT++A I
Sbjct: 2818 TEIISQFTEKIE--KMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVI 2875
Query: 223 GGKLVPAGDHWHLSDLGQLQSSSSYQ----CPQDEMSESGQSSAAA-------TPSTTGT 271
G S + +L S +YQ C D S+ GQ G
Sbjct: 2876 QCLRSKEG-----SSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGE 2930
Query: 272 KSNTPTSSVPSAAVTPL----NESLQPLG----------DYGVGSKNSKRAREKRDSRN- 316
+S + T S P L NE +Q L D+ + + E++ N
Sbjct: 2931 ESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINT 2990
Query: 317 ----------MEVQVTQEMRNVSIGMGSSDEWSDV------QDIIDSTPELDMCPETRLD 360
M++Q E+ + S S +W Q ++ L T L
Sbjct: 2991 ISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELT 3050
Query: 361 RTGSSPTQGIVNKAFGINTDSLYHELSTAGSEVIGDVD-----EGADLLGEFSGMGKEVG 415
G++ G++N L + G E ++ + LL E + ++
Sbjct: 3051 ALGTTDAVGLLN--------CLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMN 3102
Query: 416 ----------------------NLLLENSQLLETKNALNVVKNDLIAKVDQLSGEQEVLR 453
N+ + SQ+LE + L+ +K+ +QLS E+ V+
Sbjct: 3103 GRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVA 3162
Query: 454 GELEAAKQAKVKLENRIKELEEELKRVKSEAIIARREPKEEAEDV 498
Q K++LE +K + LK +++ R E K++ ++V
Sbjct: 3163 ELKSELAQTKLELETTLKAQHKHLKELEA----FRLEVKDKTDEV 3203
Score = 35.4 bits (80), Expect = 0.37
Identities = 104/507 (20%), Positives = 198/507 (39%), Gaps = 73/507 (14%)
Query: 64 ENLDSVLSENQEHEV-----ELELLREDNEQLLT----QYEREKALRRQAEEKFIEFEDA 114
EN +SEN++ E+ E++ +E+ LL +Y + L+ + + + + D
Sbjct: 1228 ENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDG 1287
Query: 115 LEQEKKELQIQVEHYEF-----QTRQLELKAKNYADQIS--------RLEERESEMKKEY 161
++ E E + E EF Q LE N+ ++S +LEE+ E++
Sbjct: 1288 MKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLI 1347
Query: 162 NALHQRHTEMIQTYVEHIE-RSKMQQVGGNSQTESSLPGRR---KERPTSLNVFPLADGT 217
++L Q+ E Q Y I K Q S SLP E ++P
Sbjct: 1348 SSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYP--GSC 1405
Query: 218 VRAQIGGKLVPAGDHW--HLSDLGQLQSSSSYQCPQDEMSESGQSSAAATPSTT------ 269
V+ I G + +G+ +++ +L + ++E+++ S + A T
Sbjct: 1406 VKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRIS 1465
Query: 270 GTKSNTPTSSVPSAAVTPLNESLQPLGDYGVGSKNSKRAREKRDSRNMEVQVTQEMRNVS 329
G K NT +S A Q Y K S+ + ++V+ +E + +S
Sbjct: 1466 GGKENTASSKQAHAV-------CQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLS 1518
Query: 330 IGMGSSDEW-----SDVQDIIDSTPELDMCPETRLDRTGSSPTQGIVNKAFGINTDSLYH 384
+G + SD DI PE C T + S IV + S++
Sbjct: 1519 KELGEHGKEILLSNSDPHDI----PESKDCVLTISEEMFSKDKTFIVRQ-------SIHD 1567
Query: 385 ELSTAGSEVIGDVDEGADLL---GEFSGMGKEVGNLLLENSQLLETKNALNVVKNDLIAK 441
E+S + +D L+ + M +E+ E+ Q E ++ + + +
Sbjct: 1568 EIS------VSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMER-QR 1620
Query: 442 VDQLSGEQEVLRGELEAAKQAKVKLENRIKELE----EELKRVKSEAIIARREPKEEAED 497
DQ ++E+ R + A+++ + EN + E E EEL+ +K ++ R + E +
Sbjct: 1621 EDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRN 1680
Query: 498 VSSYLCTESDKIPMAQRRRFTRVEMAR 524
S+ ++ + + F E+ R
Sbjct: 1681 SSTQTQNGNENQGEVEEQTFKEKELDR 1707
Score = 33.1 bits (74), Expect = 1.8
Identities = 33/146 (22%), Positives = 66/146 (45%), Gaps = 29/146 (19%)
Query: 67 DSVLSENQEHEVELELLREDNE----QLLTQYEREKALRRQ---------------AEEK 107
D+ LSE Q +EL++L E + ++ + +RE+ L Q +E+
Sbjct: 3285 DAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDL 3344
Query: 108 FIEFEDALEQEKK---ELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNAL 164
E + LE++ EL + E Y+ + L+ + ++ ++ + + ++E N
Sbjct: 3345 LKELQKQLEEKHSRIVELLNETEKYKLDS----LQTRQQMEKDRQVHRKTLQTEQEANTE 3400
Query: 165 HQRHTEMIQTYVEHIER---SKMQQV 187
Q+ +Q+ VE ++R K QQV
Sbjct: 3401 GQKKMHELQSKVEDLQRQLEEKRQQV 3426
Score = 30.8 bits (68), Expect = 9.0
Identities = 26/92 (28%), Positives = 43/92 (46%), Gaps = 4/92 (4%)
Query: 398 DEGADLLGEFSGMGKEVGNLLLENSQLLET----KNALNVVKNDLIAKVDQLSGEQEVLR 453
DE + E MG+ V E + LE K L+ +DL ++ Q GE L
Sbjct: 918 DEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLN 977
Query: 454 GELEAAKQAKVKLENRIKELEEELKRVKSEAI 485
E+++ KQ K ++ R +ELE + ++E +
Sbjct: 978 EEVKSLKQEKEQVSLRCRELEIIINHNRAENV 1009
>gi|56961680 coiled-coil domain containing 147 [Homo sapiens]
Length = 872
Score = 53.9 bits (128), Expect = 1e-06
Identities = 37/174 (21%), Positives = 88/174 (50%), Gaps = 9/174 (5%)
Query: 12 VVVYQDDYCSGSVMSERVSGLAGSIYREFERLIHCYDEEVVKELMPLVVNVLENLDSVLS 71
++ +++ + + + E+ SGL+ + L+ + EEV KE L+ V++ +S L+
Sbjct: 120 ILALKEEIVNLTKLVEQGSGLSMDQHSNIRDLLR-FKEEVTKERDQLLSEVVKLRES-LA 177
Query: 72 ENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKELQIQVEHYEF 131
+ E + E E +E+ E ++Q+++E R+ + ++ LE+E K++Q ++ +
Sbjct: 178 QTTEQQQETERSKEEAEHAISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQT 237
Query: 132 QTRQLELKAKNYADQISRLEERESEMK-------KEYNALHQRHTEMIQTYVEH 178
+ + L+ + +++ +LE++ E K KE R+ ++ Q +H
Sbjct: 238 EIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQH 291
Score = 41.6 bits (96), Expect = 0.005
Identities = 44/167 (26%), Positives = 84/167 (50%), Gaps = 19/167 (11%)
Query: 38 REFERLIHCYDEEVVKELMPLVVNVLENLDSVLSENQEHEVELELLREDNEQLLTQYERE 97
REF + E++ KEL + ++DS +E + + ++ +E+ ++L Q + +
Sbjct: 213 REFRK-----KEKLEKELK----QIQADMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQ 263
Query: 98 KALRRQAEEKFIEFE---DALEQEKKELQIQVEHY--EFQTRQLELKAKNYADQISRLEE 152
K L +A ++ +F+ L+QE ++ + E E Q + LELKAK +++ ++
Sbjct: 264 KILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKALELKAKE--EEVHQMRL 321
Query: 153 RESEMKKEYNALHQR--HTEMIQTYVE-HIERSKMQQVGGNSQTESS 196
++ K +H++ HTE + VE H E K Q VG + E+S
Sbjct: 322 DIGKLNKIREQIHKKLHHTEDQKAEVEQHKETLKNQIVGLEREVEAS 368
Score = 37.0 bits (84), Expect = 0.13
Identities = 27/117 (23%), Positives = 55/117 (47%), Gaps = 8/117 (6%)
Query: 59 VVNVLENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRR--QAEEKFIEFEDALE 116
++ + L L E VE ELL ++ E+L + + A + +A E+ + L
Sbjct: 726 LIQKIHTLQKRLISKTEEVVEKELLLQEKEKLYMELKHVLARQPGPEAAEQLKLYRRTLH 785
Query: 117 QEKKELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQ 173
+K++L++ + E+++K Y ++ +L +KK+Y L Q+ E +Q
Sbjct: 786 DKKQQLKV----LSSELNMYEVQSKEYKYEVEKLTNELQNLKKKY--LAQKRKEQLQ 836
Score = 33.5 bits (75), Expect = 1.4
Identities = 33/167 (19%), Positives = 79/167 (47%), Gaps = 20/167 (11%)
Query: 29 VSGLAGSIYREFERLIHCYD-EEVVKELMPLVVNVLENLDSVLSENQ-----EHEVELEL 82
++ L I + ++ + YD E+ KE + + + NL ++ + +H +L
Sbjct: 92 IASLKKEIEKAWKMVDSAYDKEQKAKETILALKEEIVNLTKLVEQGSGLSMDQHSNIRDL 151
Query: 83 LR------EDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKELQIQVEHYEFQTRQL 136
LR ++ +QLL++ + + Q E+ + E+ K+E + + ++ + +Q
Sbjct: 152 LRFKEEVTKERDQLLSEVVKLRESLAQTTEQ----QQETERSKEEAEHAISQFQQEIQQR 207
Query: 137 ELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIERSK 183
+ +A + + E+ E E+K+ + R TE I+ +++++SK
Sbjct: 208 QNEASR---EFRKKEKLEKELKQIQADMDSRQTE-IKALQQYVQKSK 250
Score = 33.5 bits (75), Expect = 1.4
Identities = 30/145 (20%), Positives = 71/145 (48%), Gaps = 12/145 (8%)
Query: 406 EFSGMGKEVGNLLLENSQLLETKNALNVVKNDLIAKVDQLSGEQEVLRGELEAAKQAKVK 465
E + M +++ ++ + +L E +A L + ++ E+E L+ EL+ +Q ++
Sbjct: 511 EITDMKRKLKIMIHQVDELKEDISAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALE 570
Query: 466 LENRIKELEEE---LKRVKSEAIIARREPKEEAEDV-------SSYLCTESDKIPMAQRR 515
++ I++ E E L R+ +EA R K+E + V S L +D++ + +
Sbjct: 571 TKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQVISERDILGSQLVRRNDELALLYEK 630
Query: 516 RFTRVEMARVLMERNQYKERLMELQ 540
+++ + + +QY +RL +++
Sbjct: 631 --IKIQQSVLNKGESQYNQRLEDMR 653
Score = 32.3 bits (72), Expect = 3.1
Identities = 27/125 (21%), Positives = 60/125 (48%), Gaps = 13/125 (10%)
Query: 72 ENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFE----DALEQEKKELQIQVE 127
EN++H + E L ++N+Q KAL +A+E+ + L + ++++ ++
Sbjct: 287 ENEQHSLVCEQLSQENQQ--------KALELKAKEEEVHQMRLDIGKLNKIREQIHKKLH 338
Query: 128 HYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIERSKMQQV 187
H E Q ++E + +QI L ERE E K+ L ++ + + + + ++ ++ V
Sbjct: 339 HTEDQKAEVEQHKETLKNQIVGL-EREVEASKKQAELDRKAMDELLRERDILNKNMLKAV 397
Query: 188 GGNSQ 192
+
Sbjct: 398 NATQK 402
Score = 30.8 bits (68), Expect = 9.0
Identities = 28/140 (20%), Positives = 67/140 (47%), Gaps = 16/140 (11%)
Query: 62 VLENLDSVLSENQEHEVELELLREDNEQLLTQYERE-KALRRQAE------EKFIEFEDA 114
+ E + L ++ + E+E +E + + ERE +A ++QAE ++ + D
Sbjct: 329 IREQIHKKLHHTEDQKAEVEQHKETLKNQIVGLEREVEASKKQAELDRKAMDELLRERDI 388
Query: 115 LEQE--------KKELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQ 166
L + +K+ + V+ +E R LE + +NY D+ + + ++KE +
Sbjct: 389 LNKNMLKAVNATQKQTDL-VKLHEQAKRNLEGEIQNYKDEAQKQRKIIFHLEKERDRYIN 447
Query: 167 RHTEMIQTYVEHIERSKMQQ 186
+ +++ Q + ++E K+++
Sbjct: 448 QASDLTQKVLMNMEDIKVRE 467
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 52.8 bits (125), Expect = 2e-06
Identities = 102/526 (19%), Positives = 213/526 (40%), Gaps = 40/526 (7%)
Query: 49 EEVVKELMPLVVNVLENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKF 108
E ++E ++ + + L + QE E E + ++E+ E L Q E KA E++
Sbjct: 1935 ERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQL 1994
Query: 109 IEFEDALEQEKKELQIQVE----HYEFQTRQLELKAKNYADQISRLEERESEMKKEYNAL 164
++ + L +EK E+Q Q E + Q + LE+ + +Q+SR E E E E L
Sbjct: 1995 LQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVE---EQVSRFIELEQEKNTELMDL 2051
Query: 165 HQRHTEMIQTYVEHIERSKMQQVGGNSQTESSLPGRRKERPTSLNVF----PLADGTVR- 219
Q++ + ++ +E + + +Q ++ L V P+++ R
Sbjct: 2052 RQQN-QALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTRE 2110
Query: 220 -AQIGGKLVPAGDHWHLSDLGQLQSSSSYQCPQDEMSESGQSSAAATPSTTGTKSNTPTS 278
Q+ L D L + Q Q ++E E + +
Sbjct: 2111 VEQLANHLKEKTDKCSELLLSKEQLQRDIQ-ERNEEIEKLEFRVRELEQALLVEDRKHFG 2169
Query: 279 SVPSAAVTPLNESLQPLGDYGVGSKNSKRAREKRDSRNMEVQVTQ---EMRNVSIGMGSS 335
+V + L LQ ++ R++++ N+E Q+ Q E+ N + +
Sbjct: 2170 AVEAKPELSLEVQLQ--------AERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQL 2221
Query: 336 DEWSDVQDIIDSTPELDMCPETRLDRTGSSPTQGIVNKAFGINTDSLYHELSTAGSEVIG 395
++Q +T ++ E +L + + ++ ++T H L +++I
Sbjct: 2222 HMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQD-QHVLFGKFAQIIQ 2280
Query: 396 DVDEGADLLGEFSGMGKEVGNLLLENSQLLETKNALNVVKNDLIAKVDQLSGEQEVLRGE 455
+ + D L E ++ + +N +++E KN L DL +++ L +QE ++
Sbjct: 2281 EKEVEIDQLNEQVTKLQQQLKITTDN-KVIEEKNEL---IRDLETQIECLMSDQECVKRN 2336
Query: 456 LEAAKQAKVKLENRIKELEEELKRVKSEAIIARREPKEEAEDVSSYL-CTESDKIPMAQR 514
E + +L I++L++EL + + + EEA+ + L ++K+ + Q+
Sbjct: 2337 REEEIE---QLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQ 2393
Query: 515 RRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASREHPSVQE 560
EM +N KE ++ + + E+ RE SV++
Sbjct: 2394 VETANEEMT---FMKNVLKETNFKMNQLTQ--ELFSLKRERESVEK 2434
Score = 40.4 bits (93), Expect = 0.011
Identities = 37/152 (24%), Positives = 72/152 (47%), Gaps = 22/152 (14%)
Query: 27 ERVSGLAGSIYREFERLIHCYDEEVVKE-LMPLVVNVLENLDSVLSENQEHEVELELLRE 85
+++ GL + ++ E + D + K+ + L ++ L++L L ++ E+ L++
Sbjct: 665 QQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINEL 724
Query: 86 DNE-QLLTQYEREKALRRQAEEKFIEFEDALEQEKKELQIQVEHYEFQTRQLELKAKNYA 144
E ++L Q E+EK LEQE +ELQ++ E E +Q++ K +
Sbjct: 725 QKEIEILRQEEKEKG--------------TLEQEVQELQLKTELLE---KQMKEKENDLQ 767
Query: 145 DQISRLEERESEMKKEYNALHQR---HTEMIQ 173
++ ++LE S +K E L HT + Q
Sbjct: 768 EKFAQLEAENSILKDEKKTLEDMLKIHTPVSQ 799
Score = 38.5 bits (88), Expect = 0.043
Identities = 33/156 (21%), Positives = 70/156 (44%), Gaps = 22/156 (14%)
Query: 405 GEFSGMGKEVGNLLLENSQLLETKNALNVVKNDLIAKVDQLSGEQEVLRGELEAAKQAKV 464
GE + N+ + Q+ +NV N+L K+ + ++E L+ EL + K
Sbjct: 469 GEMENALRSYSNITVNEDQI----KLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKC 524
Query: 465 KLENRIKELEEELKRVKSEAIIARREPKEE-------------AEDVSSYLCTESD---K 508
L+ ++++L EEL + + AR+ E+ ED+ + + + S+ +
Sbjct: 525 ALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKE 584
Query: 509 IPMAQRRRFT--RVEMARVLMERNQYKERLMELQEA 542
+ + T ++++ + E+N +R+ E QEA
Sbjct: 585 LELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEA 620
Score = 36.6 bits (83), Expect = 0.16
Identities = 104/525 (19%), Positives = 193/525 (36%), Gaps = 109/525 (20%)
Query: 49 EEVVKELMPLVVNVLENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKF 108
E++ +EL+ N + +L LS+ ++H E + + L+ E+E Q +K
Sbjct: 2705 EKLQEELLVKETN-MTSLQKDLSQVRDHLAEAK-------EKLSILEKEDETEVQESKKA 2756
Query: 109 IEFEDALEQEKKELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQRH 168
FE + K + Q + L++ + N QI ++ ++ + +
Sbjct: 2757 CMFEPLPIKLSKSIASQTDG------TLKISSSNQTPQIL-VKNAGIQINLQSECSSEEV 2809
Query: 169 TEMIQTYVEHIERSKMQQVGG------NSQTESSLPGRRKERPTSLNVFPLADGTVRAQI 222
TE+I + E IE KMQ++ S+ S ++E ++ + GT++A I
Sbjct: 2810 TEIISQFTEKIE--KMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVI 2867
Query: 223 GGKLVPAGDHWHLSDLGQLQSSSSYQ----CPQDEMSESGQSSAAA-------TPSTTGT 271
G S + +L S +YQ C D S+ GQ G
Sbjct: 2868 QCLRSKEG-----SSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGE 2922
Query: 272 KSNTPTSSVPSAAVTPL----NESLQPLG----------DYGVGSKNSKRAREKRDSRN- 316
+S + T S P L NE +Q L D+ + + E++ N
Sbjct: 2923 ESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINT 2982
Query: 317 ----------MEVQVTQEMRNVSIGMGSSDEWSDV------QDIIDSTPELDMCPETRLD 360
M++Q E+ + S S +W Q ++ L T L
Sbjct: 2983 ISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELT 3042
Query: 361 RTGSSPTQGIVNKAFGINTDSLYHELSTAGSEVIGDVD-----EGADLLGEFSGMGKEVG 415
G++ G++N L + G E ++ + LL E + ++
Sbjct: 3043 ALGTTDAVGLLN--------CLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMN 3094
Query: 416 ----------------------NLLLENSQLLETKNALNVVKNDLIAKVDQLSGEQEVLR 453
N+ + SQ+LE + L+ +K+ +QLS E+ V+
Sbjct: 3095 GRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVA 3154
Query: 454 GELEAAKQAKVKLENRIKELEEELKRVKSEAIIARREPKEEAEDV 498
Q K++LE +K + LK +++ R E K++ ++V
Sbjct: 3155 ELKSELAQTKLELETTLKAQHKHLKELEA----FRLEVKDKTDEV 3195
Score = 35.4 bits (80), Expect = 0.37
Identities = 104/507 (20%), Positives = 198/507 (39%), Gaps = 73/507 (14%)
Query: 64 ENLDSVLSENQEHEV-----ELELLREDNEQLLT----QYEREKALRRQAEEKFIEFEDA 114
EN +SEN++ E+ E++ +E+ LL +Y + L+ + + + + D
Sbjct: 1228 ENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDG 1287
Query: 115 LEQEKKELQIQVEHYEF-----QTRQLELKAKNYADQIS--------RLEERESEMKKEY 161
++ E E + E EF Q LE N+ ++S +LEE+ E++
Sbjct: 1288 MKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLI 1347
Query: 162 NALHQRHTEMIQTYVEHIE-RSKMQQVGGNSQTESSLPGRR---KERPTSLNVFPLADGT 217
++L Q+ E Q Y I K Q S SLP E ++P
Sbjct: 1348 SSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYP--GSC 1405
Query: 218 VRAQIGGKLVPAGDHW--HLSDLGQLQSSSSYQCPQDEMSESGQSSAAATPSTT------ 269
V+ I G + +G+ +++ +L + ++E+++ S + A T
Sbjct: 1406 VKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRIS 1465
Query: 270 GTKSNTPTSSVPSAAVTPLNESLQPLGDYGVGSKNSKRAREKRDSRNMEVQVTQEMRNVS 329
G K NT +S A Q Y K S+ + ++V+ +E + +S
Sbjct: 1466 GGKENTASSKQAHAV-------CQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLS 1518
Query: 330 IGMGSSDEW-----SDVQDIIDSTPELDMCPETRLDRTGSSPTQGIVNKAFGINTDSLYH 384
+G + SD DI PE C T + S IV + S++
Sbjct: 1519 KELGEHGKEILLSNSDPHDI----PESKDCVLTISEEMFSKDKTFIVRQ-------SIHD 1567
Query: 385 ELSTAGSEVIGDVDEGADLL---GEFSGMGKEVGNLLLENSQLLETKNALNVVKNDLIAK 441
E+S + +D L+ + M +E+ E+ Q E ++ + + +
Sbjct: 1568 EIS------VSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMER-QR 1620
Query: 442 VDQLSGEQEVLRGELEAAKQAKVKLENRIKELE----EELKRVKSEAIIARREPKEEAED 497
DQ ++E+ R + A+++ + EN + E E EEL+ +K ++ R + E +
Sbjct: 1621 EDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRN 1680
Query: 498 VSSYLCTESDKIPMAQRRRFTRVEMAR 524
S+ ++ + + F E+ R
Sbjct: 1681 SSTQTQNGNENQGEVEEQTFKEKELDR 1707
Score = 34.7 bits (78), Expect = 0.63
Identities = 33/133 (24%), Positives = 58/133 (43%), Gaps = 12/133 (9%)
Query: 38 REFERLIHCYDEEVVKELMPLVVNVLENLDSVLSENQEHEVELELLREDNEQLLTQYERE 97
+E L+ E + E P+ +L+ + ++ E E + + E +R+D ++ +
Sbjct: 1970 QEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQV------ 2023
Query: 98 KALRRQAEE---KFIEFEDALEQEKKELQIQVEHYEFQTRQLELKAKNYADQISRLEERE 154
KAL EE +FIE E E +L+ Q + E +QLE K +Q E
Sbjct: 2024 KALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALE---KQLEKMRKFLDEQAIDREHER 2080
Query: 155 SEMKKEYNALHQR 167
++E L Q+
Sbjct: 2081 DVFQQEIQKLEQQ 2093
Score = 33.1 bits (74), Expect = 1.8
Identities = 33/146 (22%), Positives = 66/146 (45%), Gaps = 29/146 (19%)
Query: 67 DSVLSENQEHEVELELLREDNE----QLLTQYEREKALRRQ---------------AEEK 107
D+ LSE Q +EL++L E + ++ + +RE+ L Q +E+
Sbjct: 3277 DAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDL 3336
Query: 108 FIEFEDALEQEKK---ELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNAL 164
E + LE++ EL + E Y+ + L+ + ++ ++ + + ++E N
Sbjct: 3337 LKELQKQLEEKHSRIVELLNETEKYKLDS----LQTRQQMEKDRQVHRKTLQTEQEANTE 3392
Query: 165 HQRHTEMIQTYVEHIER---SKMQQV 187
Q+ +Q+ VE ++R K QQV
Sbjct: 3393 GQKKMHELQSKVEDLQRQLEEKRQQV 3418
Score = 30.8 bits (68), Expect = 9.0
Identities = 26/92 (28%), Positives = 43/92 (46%), Gaps = 4/92 (4%)
Query: 398 DEGADLLGEFSGMGKEVGNLLLENSQLLET----KNALNVVKNDLIAKVDQLSGEQEVLR 453
DE + E MG+ V E + LE K L+ +DL ++ Q GE L
Sbjct: 918 DEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLN 977
Query: 454 GELEAAKQAKVKLENRIKELEEELKRVKSEAI 485
E+++ KQ K ++ R +ELE + ++E +
Sbjct: 978 EEVKSLKQEKEQVSLRCRELEIIINHNRAENV 1009
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 52.8 bits (125), Expect = 2e-06
Identities = 107/544 (19%), Positives = 219/544 (40%), Gaps = 59/544 (10%)
Query: 25 MSERVSGLAGSIYREFERLIHCYDEEVVKELMPLVVNVLENLDSVLSENQEHEVELELLR 84
+S++V L I +E + L +C + + K+LM LE L EN E ++++ L
Sbjct: 503 LSKKVEILENEIVQEKQSLQNC--QNLSKDLMKEKAQ-LEKTIETLRENSERQIKI--LE 557
Query: 85 EDNEQL---LTQYEREKALRRQAEEKFIEFEDALEQEK-KELQIQVEHYEFQTRQLELKA 140
++NE L ++ + + +A K IE E+ + E KE ++ EF+ RQ++ +
Sbjct: 558 QENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKEL 617
Query: 141 KNYADQISRLEERESEMK--KEYNALHQRHTEMIQTYVEHIERSKMQQVGGNSQTESSLP 198
++Y ++ R EE E+E+ ++ N L Q+ ++ E IE + + NS+ E
Sbjct: 618 EHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQE----NSELE---- 669
Query: 199 GRRKERPTSLNVFPLADGTVRAQIGGKLVPAGDHWHLSDLGQLQSSSSYQCPQDEMSESG 258
R+ R + + T + + L +L ++ S +C +M++
Sbjct: 670 --RENRKLKKTLDSFKNLTFQLE---SLEKENSQLDEENLELRRNVESLKCASMKMAQLQ 724
Query: 259 QSSAAATPSTTGTKSNTPTSSVPSAAVTPLNESLQPLGDYGVGSKNSKRAREKRDSRNME 318
+ K L S Q G+ +N + + +S
Sbjct: 725 LENKELESEKEQLKKGLELLKASFKKTERLEVSYQ-----GLDIENQRLQKTLENSNKKI 779
Query: 319 VQVTQEMRNVSIGMGSSDEWSDVQDIIDSTPELDMCPETRLDRTGSSPTQGIVNKAFGIN 378
Q+ E++++ M + +++++ S+ L+ + + K
Sbjct: 780 QQLESELQDLE--MENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKE 837
Query: 379 TDSLYHELSTAGSEV------IGDVDEGADLLGEFSGMGKE----VGNLLLENSQLLETK 428
L + + + IG++++ L + G+ KE + L EN +L++
Sbjct: 838 NKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRA 897
Query: 429 ----NALNVVKNDLIA---KVDQLSGEQEVLRGELEAAKQAKVKL-------ENRIKELE 474
L ++ DL++ K Q++ + E L ELE K +L ++R K LE
Sbjct: 898 TIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLE 957
Query: 475 EELKRVKSEAIIARREPKEEAEDVSSYLCTESDKIPMAQRRRFTRVEMARVLMERNQYKE 534
+L+ +++ E KEE ES R+ V+ +++ Q +E
Sbjct: 958 SKLESTLKKSL----EIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEE 1013
Query: 535 RLME 538
R+++
Sbjct: 1014 RMVQ 1017
Score = 43.5 bits (101), Expect = 0.001
Identities = 100/531 (18%), Positives = 207/531 (38%), Gaps = 62/531 (11%)
Query: 48 DEEVVKEL---MPLVVNVLENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQA 104
++E+VK + +V + E+L S + Q+ +LE L + E++ ER +
Sbjct: 890 NKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQST 949
Query: 105 EEKFIEFEDALEQE-KKELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNA 163
++++ E LE KK L+I+ E +LE ++ NY Q L + +KK Y A
Sbjct: 950 DDRYKLLESKLESTLKKSLEIKEEKIAALEARLE-ESTNYNQQ---LRQELKTVKKNYEA 1005
Query: 164 LHQRHTEMIQTYVEHIERSKMQQVGGNSQTESSLPGRRKERPTSLNVFPLADGTVRAQIG 223
L QR E E + +S G +++ E R+ + T+ + + D + +
Sbjct: 1006 LKQRQDE------ERMVQSSPPISGEDNKWE------RESQETTRELLKVKDRLIEVERN 1053
Query: 224 GKLVPAGDHWHLSDLGQLQSSSS---YQCPQDEMSESGQSSAAATPSTTGTKSNTPTSSV 280
+ A + L QL++ ++ Q + T T K S++
Sbjct: 1054 NATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTL 1113
Query: 281 PSAAVTPLNESLQPLGDYGVGSKNSKRAREKRDSRNMEVQVTQEMRNVSIGMGSSDEWSD 340
S + + +N++ Q L Q + E N S+ D S
Sbjct: 1114 NSQSTSLMNQNAQLLIQ----------------------QSSLENENESVIKEREDLKSL 1151
Query: 341 VQDIIDSTPELDMCPETRLDRTGSSPTQGIVNKAFGINTDSLYHELSTAGSEVIGDVDEG 400
+I +L++ E + S ++ K+ N + + +L ++++ +
Sbjct: 1152 YDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQL 1211
Query: 401 ADLLGEFSGMGKEVGNLLLEN----------SQLLETKNALNVVKNDLIAKVDQLSGEQE 450
DL + E +LLEN +L + LN + L+ + + L + +
Sbjct: 1212 EDL---EKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHK 1268
Query: 451 VLRGELEAAKQAKVKLENRIKELEEELKRVKSEAIIARREPKEEAEDVSSYLCTESDKIP 510
L+ L +K + +LE +L+E+ +++ I + + E +S ++
Sbjct: 1269 NLKSLLNNSKLEQTRLEAEFSKLKEQYQQLD----ITSTKLNNQCELLSQLKGNLEEENR 1324
Query: 511 MAQRRRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASREHPSVQEK 561
+ T + R L+E+N + L +++ ++ R+ ++EK
Sbjct: 1325 HLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEK 1375
Score = 37.0 bits (84), Expect = 0.13
Identities = 111/603 (18%), Positives = 229/603 (37%), Gaps = 112/603 (18%)
Query: 53 KELMPLVVNVLENLDSVLSENQEHEVELELLREDNE------------------------ 88
+++ PL+ N+ +L ++ E EH + L E+ +
Sbjct: 184 EDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRT 243
Query: 89 --------QLLTQYEREKALRRQAEEKFIEFEDALEQEKKELQIQVEHYEFQTRQL---E 137
+L + + LR++ EEK + D +QE ++++I+++ + + L
Sbjct: 244 ESRQHLSVELADAKAKIRRLRQELEEKTEQLLDC-KQELEQMEIELKRLQQENMNLLSDA 302
Query: 138 LKAKNYADQISRLEER-------ESEMKKEYNALHQRHTEMIQTYVEHIERSKMQQVGGN 190
A+ Y D++ L E+ ESE+ + LH E + VE ++ +
Sbjct: 303 RSARMYRDELDALREKAVRVDKLESEVSRYKERLHD--IEFYKARVEELKEDNQVLLETK 360
Query: 191 SQTESSLPGRRKERPTSLNVFPLADGTVRAQIGG----------KLVPAGDHWHLSDLGQ 240
+ E L G R R L+ + ++A++ K+ + ++ Q
Sbjct: 361 TMLEDQLEGTR-ARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQ 419
Query: 241 LQSSSSYQCPQDEMSESGQSS--AAATPSTTGTKSNTPTSS------VPSAAVTPLNESL 292
QS E+ + ++S + A + G + N TSS + + ++T E L
Sbjct: 420 KQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEEL 479
Query: 293 QPLGDYGVGSKNSKRAREKRDSR------NMEVQVTQEMRNVSIGMGSSDEWSDVQDIID 346
+ D G+ + EK + R +E ++ QE +++ S +D++
Sbjct: 480 RTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLS------KDLMK 533
Query: 347 STPELDMCPETRLDRTGSSPTQGIV---NKAFGINTDSLYHELSTAGSEVIGDVDEGADL 403
+L+ ET R S I+ N+ SL + + D+++ +
Sbjct: 534 EKAQLEKTIETL--RENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKI 591
Query: 404 LGE-FSGMGKEVGNLLLENSQL---LETKNALNVVKNDLIAKVDQLSGEQEVLR------ 453
L E ++ + E Q+ LE +L ++ L E E+L+
Sbjct: 592 LHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNL 651
Query: 454 ----GELEAAKQAKVKLENRIKELEEELKRVKSEAIIARREPKEEAE----------DVS 499
++EA +Q +LE ++L++ L K+ KE ++ +V
Sbjct: 652 KITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVE 711
Query: 500 SYLCTESDKIPMAQRRRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASREHPSVQ 559
S C + MAQ ++E + E+ Q K+ L L+ + + TE + S + ++
Sbjct: 712 SLKCA---SMKMAQ----LQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIE 764
Query: 560 EKK 562
++
Sbjct: 765 NQR 767
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 52.4 bits (124), Expect = 3e-06
Identities = 107/545 (19%), Positives = 219/545 (40%), Gaps = 60/545 (11%)
Query: 25 MSERVSGLAGSIYREFERLIHCYDEEVVKELMPLVVNVLENLDSVLSENQEHEVELELLR 84
+S++V L I +E + L +C + + K+LM LE L EN E ++++ L
Sbjct: 503 LSKKVEILENEIVQEKQSLQNC--QNLSKDLMKEKAQ-LEKTIETLRENSERQIKI--LE 557
Query: 85 EDNEQL---LTQYEREKALRRQAEEKFIEFEDALEQEK-KELQIQVEHYEFQTRQLELKA 140
++NE L ++ + + +A K IE E+ + E KE ++ EF+ RQ++ +
Sbjct: 558 QENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKEL 617
Query: 141 KNYADQISRLEERESEMK--KEYNALHQRHTEMIQTYVEHIERSKMQQVGGNSQTESSLP 198
++Y ++ R EE E+E+ ++ N L Q+ ++ E IE + + NS+ E
Sbjct: 618 EHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQE----NSELE---- 669
Query: 199 GRRKERPTSLNVFPLADGTVRAQIGGKLVPAGDHWHLSDLGQLQSSSSYQCPQDEMSESG 258
R+ R + + T + + L +L ++ S +C +M++
Sbjct: 670 --RENRKLKKTLDSFKNLTFQLE---SLEKENSQLDEENLELRRNVESLKCASMKMAQLQ 724
Query: 259 QSSAAATPSTTGTKSNTPTSSVPSAAVTPLNESLQPLGDYGVGSKNSKRAREKRDSRNME 318
+ K L S Q G+ +N + + +S
Sbjct: 725 LENKELESEKEQLKKGLELLKASFKKTERLEVSYQ-----GLDIENQRLQKTLENSNKKI 779
Query: 319 VQVTQEMRNVSIGMGSSDEWSDVQDIIDSTPELDMCPETRLDRTGSSPTQGIVNKAFGIN 378
Q+ E++++ M + +++++ S+ L+ + + K
Sbjct: 780 QQLESELQDLE--MENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKE 837
Query: 379 TDSLYHELSTAGSEV------IGDVDEGADLLGEFSGMGKE----VGNLLLENSQLLETK 428
L + + + IG++++ L + G+ KE + L EN +L++
Sbjct: 838 NKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRA 897
Query: 429 ----NALNVVKNDLIA---KVDQLSGEQEVLRGELEAAKQAKVKL--------ENRIKEL 473
L ++ DL++ K Q++ + E L ELE K +L ++R K L
Sbjct: 898 TIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLL 957
Query: 474 EEELKRVKSEAIIARREPKEEAEDVSSYLCTESDKIPMAQRRRFTRVEMARVLMERNQYK 533
E +L+ +++ E KEE ES R+ V+ +++ Q +
Sbjct: 958 ESKLESTLKKSL----EIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDE 1013
Query: 534 ERLME 538
ER+++
Sbjct: 1014 ERMVQ 1018
Score = 38.9 bits (89), Expect = 0.033
Identities = 100/532 (18%), Positives = 207/532 (38%), Gaps = 63/532 (11%)
Query: 48 DEEVVKEL---MPLVVNVLENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQA 104
++E+VK + +V + E+L S + Q+ +LE L + E++ ER +
Sbjct: 890 NKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQST 949
Query: 105 EE-KFIEFEDALEQE-KKELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYN 162
++ ++ E LE KK L+I+ E +LE ++ NY Q L + +KK Y
Sbjct: 950 DDSRYKLLESKLESTLKKSLEIKEEKIAALEARLE-ESTNYNQQ---LRQELKTVKKNYE 1005
Query: 163 ALHQRHTEMIQTYVEHIERSKMQQVGGNSQTESSLPGRRKERPTSLNVFPLADGTVRAQI 222
AL QR E E + +S G +++ E R+ + T+ + + D + +
Sbjct: 1006 ALKQRQDE------ERMVQSSPPISGEDNKWE------RESQETTRELLKVKDRLIEVER 1053
Query: 223 GGKLVPAGDHWHLSDLGQLQSSSS---YQCPQDEMSESGQSSAAATPSTTGTKSNTPTSS 279
+ A + L QL++ ++ Q + T T K S+
Sbjct: 1054 NNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENST 1113
Query: 280 VPSAAVTPLNESLQPLGDYGVGSKNSKRAREKRDSRNMEVQVTQEMRNVSIGMGSSDEWS 339
+ S + + +N++ Q L Q + E N S+ D S
Sbjct: 1114 LNSQSTSLMNQNAQLLIQ----------------------QSSLENENESVIKEREDLKS 1151
Query: 340 DVQDIIDSTPELDMCPETRLDRTGSSPTQGIVNKAFGINTDSLYHELSTAGSEVIGDVDE 399
+I +L++ E + S ++ K+ N + + +L ++++ +
Sbjct: 1152 LYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQ 1211
Query: 400 GADLLGEFSGMGKEVGNLLLEN----------SQLLETKNALNVVKNDLIAKVDQLSGEQ 449
DL + E +LLEN +L + LN + L+ + + L +
Sbjct: 1212 LEDL---EKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDH 1268
Query: 450 EVLRGELEAAKQAKVKLENRIKELEEELKRVKSEAIIARREPKEEAEDVSSYLCTESDKI 509
+ L+ L +K + +LE +L+E+ +++ I + + E +S ++
Sbjct: 1269 KNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLD----ITSTKLNNQCELLSQLKGNLEEEN 1324
Query: 510 PMAQRRRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASREHPSVQEK 561
+ T + R L+E+N + L +++ ++ R+ ++EK
Sbjct: 1325 RHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEK 1376
Score = 37.0 bits (84), Expect = 0.13
Identities = 111/603 (18%), Positives = 229/603 (37%), Gaps = 112/603 (18%)
Query: 53 KELMPLVVNVLENLDSVLSENQEHEVELELLREDNE------------------------ 88
+++ PL+ N+ +L ++ E EH + L E+ +
Sbjct: 184 EDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRT 243
Query: 89 --------QLLTQYEREKALRRQAEEKFIEFEDALEQEKKELQIQVEHYEFQTRQL---E 137
+L + + LR++ EEK + D +QE ++++I+++ + + L
Sbjct: 244 ESRQHLSVELADAKAKIRRLRQELEEKTEQLLDC-KQELEQMEIELKRLQQENMNLLSDA 302
Query: 138 LKAKNYADQISRLEER-------ESEMKKEYNALHQRHTEMIQTYVEHIERSKMQQVGGN 190
A+ Y D++ L E+ ESE+ + LH E + VE ++ +
Sbjct: 303 RSARMYRDELDALREKAVRVDKLESEVSRYKERLHD--IEFYKARVEELKEDNQVLLETK 360
Query: 191 SQTESSLPGRRKERPTSLNVFPLADGTVRAQIGG----------KLVPAGDHWHLSDLGQ 240
+ E L G R R L+ + ++A++ K+ + ++ Q
Sbjct: 361 TMLEDQLEGTR-ARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQ 419
Query: 241 LQSSSSYQCPQDEMSESGQSS--AAATPSTTGTKSNTPTSS------VPSAAVTPLNESL 292
QS E+ + ++S + A + G + N TSS + + ++T E L
Sbjct: 420 KQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEEL 479
Query: 293 QPLGDYGVGSKNSKRAREKRDSR------NMEVQVTQEMRNVSIGMGSSDEWSDVQDIID 346
+ D G+ + EK + R +E ++ QE +++ S +D++
Sbjct: 480 RTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLS------KDLMK 533
Query: 347 STPELDMCPETRLDRTGSSPTQGIV---NKAFGINTDSLYHELSTAGSEVIGDVDEGADL 403
+L+ ET R S I+ N+ SL + + D+++ +
Sbjct: 534 EKAQLEKTIETL--RENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKI 591
Query: 404 LGE-FSGMGKEVGNLLLENSQL---LETKNALNVVKNDLIAKVDQLSGEQEVLR------ 453
L E ++ + E Q+ LE +L ++ L E E+L+
Sbjct: 592 LHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNL 651
Query: 454 ----GELEAAKQAKVKLENRIKELEEELKRVKSEAIIARREPKEEAE----------DVS 499
++EA +Q +LE ++L++ L K+ KE ++ +V
Sbjct: 652 KITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVE 711
Query: 500 SYLCTESDKIPMAQRRRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASREHPSVQ 559
S C + MAQ ++E + E+ Q K+ L L+ + + TE + S + ++
Sbjct: 712 SLKCA---SMKMAQ----LQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIE 764
Query: 560 EKK 562
++
Sbjct: 765 NQR 767
>gi|115648142 centrosomal protein 164kDa [Homo sapiens]
Length = 1460
Score = 51.2 bits (121), Expect = 6e-06
Identities = 50/179 (27%), Positives = 88/179 (49%), Gaps = 20/179 (11%)
Query: 49 EEVVKELMPLVVNVLENLDSVLSENQEHEVEL---ELLREDNEQLLT---QYEREKALRR 102
E +K + V VLE L E+++ +++ +L +E+ E++L Q E+ + R
Sbjct: 589 EAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLR 648
Query: 103 QAEEKFIEFEDALEQEKKE-----LQIQVEHYEFQTRQLELKAKNYADQISRLEERESEM 157
+ +K IE E+A +E++ L+ QV+ Q + +++A+ A EE ES+
Sbjct: 649 ERLQKAIEEEEARMREEESQRLSWLRAQVQS-STQADEDQIRAEQEASLQKLREELESQQ 707
Query: 158 KKEYNALHQRHTEMIQTYVEHIERS-KMQQVGGNS-------QTESSLPGRRKERPTSL 208
K E +L Q++ +M++ E IE S K +Q N+ Q L G RKE +L
Sbjct: 708 KAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGERKEAVATL 766
Score = 37.4 bits (85), Expect = 0.097
Identities = 101/503 (20%), Positives = 195/503 (38%), Gaps = 67/503 (13%)
Query: 48 DEEVVKELMPLVVNVLENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEK 107
+E+V P V + + + V Q E L+ + E Q+L Q +R L +EK
Sbjct: 560 EEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRH--LLESKQEK 617
Query: 108 FIEFEDALEQEKKE--LQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALH 165
+ + L QE++E L++ + + + E K ++ +R+ E ES+ A
Sbjct: 618 MQQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQV 677
Query: 166 QRHTEMIQTYVEHIERSKMQQVGGNSQTESSLPGRRKERPTSLNVFPLADGTVRAQIGGK 225
Q T+ + + + + +Q++ L ++K SL Q+ +
Sbjct: 678 QSSTQADEDQIRAEQEASLQKL------REELESQQKAERASLE-------QKNRQMLEQ 724
Query: 226 LVPAGDHWHLSDLGQLQSSSSYQCPQ-DEMSESGQSSAAATPSTTGTKSNTPTSSVPSAA 284
L + S+ L ++ Q E E + A AT + S A
Sbjct: 725 LKEEIEASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAELERLCSSLEAK 784
Query: 285 VTPLNESLQPLGDYGVGSKNSKRAREKRDSR------NMEVQVTQEMRNVSIGMGSSDEW 338
+ SLQ K + A++K +++ +E +V Q+ +V+ G E
Sbjct: 785 HREVVSSLQ---------KKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVA---GYEHEL 832
Query: 339 SDVQDIIDSTPELDMCPETRLDRTGSSPTQGIVNKAFGINTDSLYHELSTAGSEVIGDVD 398
S + + + E++ E RLD+ Q + + +
Sbjct: 833 SSL--LREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAE---------------ERK 875
Query: 399 EGADLLGEFSGMGKEVGNLLLENSQLLETKNALNVVKNDLIAKVDQLSGEQEVLRGELEA 458
+ A+LLG +G E+ L + + LET V+ + +++ L R +
Sbjct: 876 QRAELLGHLTG---ELERLQRAHERELET------VRQEQHKRLEDLRRRH---REQERK 923
Query: 459 AKQAKVKLENRIKELEEELKRVKSEAIIARREPKEEAEDVSSYLCTESDKIPMA-QRRRF 517
+ ++ LE R K+++ L ++ + ARRE K++ DV + +S++ Q+
Sbjct: 924 LQDLELDLETRAKDVKARLALLEVQEETARRE-KQQLLDVQRQVALKSEEATATHQQLEE 982
Query: 518 TRVEMARVLMERNQYKERLMELQ 540
+ E +L Q +E L ELQ
Sbjct: 983 AQKEHTHLLQSNQQLREILDELQ 1005
Score = 32.7 bits (73), Expect = 2.4
Identities = 52/259 (20%), Positives = 90/259 (34%), Gaps = 61/259 (23%)
Query: 63 LENLDSVLSENQEHEVELELLREDNEQLLTQYER---------EKALRRQAEEKFIEFED 113
+E+L L NQ EV L + + L E R A+E ++
Sbjct: 1063 IEDLRKSLGTNQTKEVSSSLSQSKEDLYLDSLSSHNVWHLLSAEGVALRSAKEFLVQQTR 1122
Query: 114 ALEQEKKELQIQVEHYEFQT-------------RQLELKAKNYADQISRLEERESEMKKE 160
++ + + L+ +H+ + + LE KN + L+E +S M+K
Sbjct: 1123 SMRRRQTALKAAQQHWRHELASAQEVAKDPPGIKALEDMRKNLEKETRHLDEMKSAMRKG 1182
Query: 161 YNALHQRHTEMIQTYVEHIERSKMQQVGGNSQTESSLPGRRKERPTSLNVFPLADGTVRA 220
+N L ++ ++ +Q ESSL + T
Sbjct: 1183 HNLLKKKEEKL-------------------NQLESSLWEEASDEGT-------------- 1209
Query: 221 QIGGKLVPAGDHWHLSDLGQLQSSSSYQCPQDEMSESGQSSAAATPSTTGTKSNTPTSSV 280
+GG + LSD+ L S SS Q +TPS T K + + S+
Sbjct: 1210 -LGGSPTKKAVTFDLSDMDSLSSESSESFSPPHREWWRQQRIDSTPSLTSRKIHGLSHSL 1268
Query: 281 PS-----AAVTPLNESLQP 294
++V + +SL P
Sbjct: 1269 RQISSQLSSVLSILDSLNP 1287
>gi|93204881 Rab interacting lysosomal protein [Homo sapiens]
Length = 401
Score = 50.4 bits (119), Expect = 1e-05
Identities = 47/157 (29%), Positives = 69/157 (43%), Gaps = 23/157 (14%)
Query: 26 SERVSGLAGSIYREFERLIHCYDEEVVKELMPLVVNVLENL---------DSVLSENQEH 76
+E V LAG++ E + L + E L+PLVV LE L DS+ Q
Sbjct: 25 AELVYHLAGALGTELQDLARRFGPEAAAGLVPLVVRALELLEQAAVGPAPDSLQVSAQPA 84
Query: 77 EVELELLREDNEQLLTQY----EREKALRRQAEEKFIEFEDALE----------QEKKEL 122
E EL LRE+NE+L + + E+AL RQ +E D L QE + L
Sbjct: 85 EQELRRLREENERLRRELRAGPQEERALLRQLKEVTDRQRDELRAHNRDLRQRGQETEAL 144
Query: 123 QIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKK 159
Q Q++ +L K Q+ ++RE E ++
Sbjct: 145 QEQLQRLLLVNAELRHKLAAMQTQLRAAQDRERERQQ 181
>gi|4502443 dystonin isoform 1e precursor [Homo sapiens]
Length = 2649
Score = 50.1 bits (118), Expect = 1e-05
Identities = 92/510 (18%), Positives = 201/510 (39%), Gaps = 52/510 (10%)
Query: 88 EQLLTQYEREKALRRQAEEKFIEFEDALEQEKKELQIQVEHYEFQTRQLELKAKNYADQI 147
E+++ + +++K+ + EE+ + +A E E ++ Q VE Q + E +AK Y ++
Sbjct: 1144 ERMVAELKKQKS---RVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRREL 1200
Query: 148 SRLEERESEMKKEYNALHQR--HTEMIQTYVEHIERSKMQQVGGNSQTESSLPGRRKERP 205
+ + ++E + Q E + VE + Q+ N+ T +L K +
Sbjct: 1201 ETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKD 1260
Query: 206 TSLNVFPLADGTVRAQIGGKLVPAGDHWHLSDLGQLQSSSSYQCPQDEMSESGQSSAAAT 265
SLN + ++ K + L + + Q + ++ E + A
Sbjct: 1261 LSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEAR 1320
Query: 266 PSTTGTKSNTPTSSVPSAAVTPLNESLQPLGDYGVGSKNSKRAREKRDSRNMEV------ 319
T + +++P V P+ ++ G+ ++ K+ E+ + E+
Sbjct: 1321 RKITEIQYTCRENALP---VCPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRK 1377
Query: 320 ------QVTQEMRNVSIGMGSSDEWSD-VQDIIDSTPELDMCPETRLDRTGSSPTQGIVN 372
++T E+ + + SS+E + ++D +D T C + L+R +
Sbjct: 1378 AEQDMRELTYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQA------E 1431
Query: 373 KAFGINTDSLYHELSTAGSEVIGDVDEGADLLG-------EFSGMGKEVGNLLLENSQLL 425
K + L +L+ + + E +DL E + E G L E ++
Sbjct: 1432 KGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRIT 1491
Query: 426 ETKNALNVVKNDLIAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELEEELKRVKSE-- 483
L +++ E+E+ R ++ K +K E K E+ L+ +K+E
Sbjct: 1492 RAHAVAEKNIQHLNSQIHSFRDEKELERLQICQRKSDHLK-EQFEKSHEQLLQNIKAEKE 1550
Query: 484 ---AIIARREPKEEAEDVSSYLCTESDKIP--------MAQRRRFTRVEMARVLMERNQY 532
I E E++ + + L + +++ M QR + E +++E+
Sbjct: 1551 NNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQR---IQAESENIVLEKQTI 1607
Query: 533 KERLMELQ-EAVRWTEMIRASREHPSVQEK 561
++R L+ +A + + +R++ EH Q K
Sbjct: 1608 QQRCEALKIQADGFKDQLRSTNEHLHKQTK 1637
Score = 32.7 bits (73), Expect = 2.4
Identities = 26/119 (21%), Positives = 52/119 (43%), Gaps = 6/119 (5%)
Query: 436 NDLIAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELEEELKRVKSEAIIARREPKEEA 495
+DL+ + E L G++ ++ +L+ + +EEEL +V+ A R+ +
Sbjct: 1120 SDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQQRNV 1179
Query: 496 EDVSSYLCTESDKIPMAQRRRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRE 554
ED+S KI + R E+ ++ E+ + L +++ E RA+ E
Sbjct: 1180 EDIS------LQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVE 1232
Score = 30.8 bits (68), Expect = 9.0
Identities = 35/151 (23%), Positives = 62/151 (41%), Gaps = 25/151 (16%)
Query: 52 VKELMPLVVNVLENLDSVLSENQEHEVELELLREDNEQLLTQYER-EKALRRQAEEKFIE 110
V+EL + V + L E Q ++ L +E++ + E K + + E K I
Sbjct: 1709 VQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVIT 1768
Query: 111 FED---------ALEQEK--------------KELQIQVEHYEFQTRQLELKAKNYADQI 147
D +L+QE KEL+ Q++ Y Q +Q + N+ +
Sbjct: 1769 ENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHYQKC 1828
Query: 148 SRLEERESEMKKEYNALHQRHTEMIQTYVEH 178
+LE+ K+E L Q+ + I+ + EH
Sbjct: 1829 QKLEDELIAQKREVENLKQKMDQQIKEH-EH 1858
>gi|195947382 Rab interacting lysosomal protein-like 1 [Homo
sapiens]
Length = 403
Score = 49.3 bits (116), Expect = 2e-05
Identities = 61/228 (26%), Positives = 105/228 (46%), Gaps = 39/228 (17%)
Query: 29 VSGLAGSIYREFERLIHCYDEEVVKELMPLVVNVLENLDSVLS------ENQEHEVELEL 82
V +A + EFER+I + E + LMP VV VLE L+ ++S E E +EL+
Sbjct: 27 VYDIASLVGHEFERVIDQHGCEAIARLMPKVVRVLEILEVLVSRHHVAPELDELRLELDR 86
Query: 83 LR-EDNEQLLTQYEREKAL-------RRQAEEKFIEFEDALEQEKKELQIQVEH------ 128
LR E +++ + + +K L R +A++ + L++E K+L + H
Sbjct: 87 LRLERMDRIEKERKHQKELELVEDVWRGEAQDLLSQIAQ-LQEENKQLMTNLSHKDVNFS 145
Query: 129 -YEFQ--------TRQLELKAKNYADQIS---RLEERESEMKKE-YNALHQRHTEMIQTY 175
EFQ RQ+ K K D+ R ++RE +K E AL Q+ T +++
Sbjct: 146 EEEFQKHEGMSERERQVMKKLKEVVDKQRDEIRAKDRELGLKNEDVEALQQQQTRLMK-- 203
Query: 176 VEHIERSKMQQVGGNSQTESSLPGRRKERPTSLNVFPLADGTVRAQIG 223
+ H R ++ V + +L ++ E L G++RA++G
Sbjct: 204 INHDLRHRVTVVEAQGK---ALIEQKVELEADLQTKEQEMGSLRAELG 248
Score = 43.1 bits (100), Expect = 0.002
Identities = 49/187 (26%), Positives = 82/187 (43%), Gaps = 25/187 (13%)
Query: 406 EFSGMGKEVGNLLLENSQLLETKNALNVVKNDLIAKVDQLSGEQEVL---RGELEAAKQA 462
E +E+G + L + + L + +DL +V + + + L + ELEA Q
Sbjct: 176 EIRAKDRELGLKNEDVEALQQQQTRLMKINHDLRHRVTVVEAQGKALIEQKVELEADLQT 235
Query: 463 KVK----LENRIKELEEELKRVKSEAIIARREPKEEAEDVSSYLCTESDKIPM----AQR 514
K + L + +L E L+ S+ E + E E V ++++K+ M R
Sbjct: 236 KEQEMGSLRAELGKLRERLQGEHSQ----NGEEEPETEPVGEESISDAEKVAMDLKDPNR 291
Query: 515 RRFTRVEMARVLMERNQYKERLMELQEAVRW---TEMIRASR-------EHPSVQEKKKS 564
RFT E+ VL ERN+ K ++ LQE + + EM +R HP + +S
Sbjct: 292 PRFTLQELRDVLHERNELKSKVFLLQEELAYYKSEEMEEENRIPQPPPIAHPRTSPQPES 351
Query: 565 TIWQFFS 571
I + FS
Sbjct: 352 GIKRLFS 358
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 48.9 bits (115), Expect = 3e-05
Identities = 89/476 (18%), Positives = 186/476 (39%), Gaps = 43/476 (9%)
Query: 49 EEVVKELMPLVVNVLENLDSVLSENQEHEVE-LELLR--EDNEQLLTQYEREKALRRQAE 105
++++ E V+ +E + +E +E E L L R E+ ++ + ER+ R
Sbjct: 1479 DQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAEL 1538
Query: 106 EKFIEFEDALEQEKKELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALH 165
E + +D + + EL+ E L + D+++ E+ + ++ AL
Sbjct: 1539 EALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALK 1598
Query: 166 QRHTEMIQTYVEHIERSKMQQVGGNSQTESSLPGRRKERPTSLNVFPLADGTVRAQIGGK 225
+H +Q E E + Q E RK+R ++ +G + ++ +
Sbjct: 1599 TQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELE-ELKAQ 1657
Query: 226 LVPAGDHWHLSDLGQLQSSSSYQCPQDEMSESGQSSAAATPSTTGTKSNTPTSSVPSAAV 285
+ AG G+ ++ + Q +M E + S S S +
Sbjct: 1658 MASAGQ-------GKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGL 1710
Query: 286 TPLNESLQPLGDYGVGSKNSKRAREKRDSRNMEV--------QVTQEMRNVSIGMGSSDE 337
E L+ + + ++A++ RD EV + +E R + +G +E
Sbjct: 1711 EA--EVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEE 1768
Query: 338 WSDVQDIIDSTPELDMCPETRLDRTGSSPTQGIVNKAFGINTDSLYHELSTAGSEV---I 394
++++ ++ L+ L + S T+ ++F +S +L E+ +
Sbjct: 1769 --ELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRL 1826
Query: 395 GDVDEGADLLGEFSGMGKEVGNLLLENSQLLETKNALNVVKNDLIAKVD--------QLS 446
G+ D GA + + E + L + + LE + ++ L+ + + Q+
Sbjct: 1827 GEEDAGARARHKMTIAALE--SKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVE 1884
Query: 447 GEQEV---LRGELEAAKQAKVKLENRIKELEEELKRVKSEAIIARREPKEEAEDVS 499
E+ V LR +LE +L+ +++E EEE R ++ RR + E EDV+
Sbjct: 1885 EERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQA----GRRRLQRELEDVT 1936
Score = 35.8 bits (81), Expect = 0.28
Identities = 115/585 (19%), Positives = 216/585 (36%), Gaps = 77/585 (13%)
Query: 38 REFERLIHCYDEEVVKELMPLVVNVLENLDSVLSE--NQEHEVELELLREDNE-----QL 90
+E E+L D E EL +V + + + ++ +E E++ L R ++E QL
Sbjct: 1076 QELEKLKRRLDGES-SELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQL 1134
Query: 91 LTQY--------------EREKALRRQAEEKFIEFEDALEQEKKELQIQVEHYEFQTRQL 136
L E E+ R +AE++ + + LE + EL+ ++ Q
Sbjct: 1135 LKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELR 1194
Query: 137 ELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIERSKMQQVGGNSQTESS 196
+ + + LEE + L QRH + + E +E+++ + G +T +
Sbjct: 1195 SKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGK-GAWEKTRLA 1253
Query: 197 LPGRRKERPTSLNVFPLA--DGTVR-----AQIGGKLVPAGDHWHLSDLGQLQSSSSYQC 249
L E L+ A +G R Q+ AGD + + +++ Q
Sbjct: 1254 LEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGD----GERARAEAAEKLQR 1309
Query: 250 PQDEMSE-SGQSSAAATPSTTGTKSNTPTSSVPSAAVTPLNESLQPLGDYGVGSKNSKRA 308
Q E+ SG + A + + +K + T + A L E + +GS+ RA
Sbjct: 1310 AQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETR--AKLALGSR--VRA 1365
Query: 309 REKRDSRNMEVQVTQEM-------RNVSIGMGSSDEWSDVQDIIDSTPELDMCPETRLDR 361
E ++ + Q+ +E R + EW Q+ E R R
Sbjct: 1366 ME-AEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAR 1424
Query: 362 TGSSPTQGIVNKAFGIN-TDSLYHELSTAGSEVIGDVDEGADLLGEFSGMGKEVGNLLLE 420
+ TQ + K ++ + L + D+++ L+ ++ LL E
Sbjct: 1425 EAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAE 1484
Query: 421 NS----QLLETKNALNVVKNDLIAKV--------------DQLSGEQEVLRGELEAAKQA 462
+ +E + + A+ ++L + LR ELEA +
Sbjct: 1485 EKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSS 1544
Query: 463 KVKLENRIKELEEELKRVKSEAIIARREPKEEAEDVSSYLCTESDKIPMAQRRRFTRVEM 522
K + + ELE RV +A R E ED E K+ + + + +
Sbjct: 1545 KDDVGKSVHELERAC-RVAEQAANDLRAQVTELED--ELTAAEDAKLRLEVTVQALKTQH 1601
Query: 523 ARVLMERNQY-KERLMELQEAVRWTEMIRASREHPSVQEKKKSTI 566
R L R++ +ER +L + +R E+ R +E+K+ T+
Sbjct: 1602 ERDLQGRDEAGEERRRQLAKQLRDAEVERD-------EERKQRTL 1639
Score = 35.4 bits (80), Expect = 0.37
Identities = 31/112 (27%), Positives = 53/112 (47%), Gaps = 14/112 (12%)
Query: 79 ELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKELQIQVEHYEFQTRQLEL 138
ELEL+ + E + + E E + + Q E+K L+Q +EL+ +E E ++L+L
Sbjct: 944 ELELVVSELEARVGE-EEECSRQMQTEKK------RLQQHIQELEAHLEAEEGARQKLQL 996
Query: 139 -------KAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIERSK 183
K K + + + LE++ S++ KE L R E E E+ K
Sbjct: 997 EKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVK 1048
Score = 30.8 bits (68), Expect = 9.0
Identities = 34/131 (25%), Positives = 57/131 (43%), Gaps = 21/131 (16%)
Query: 74 QEHEVELELLREDNEQLLTQYEREK----ALRRQAEEKFIEFED---ALEQEKKELQIQV 126
Q+H ELE E E + + EK A ++ EE + ED L +E+K L+ ++
Sbjct: 974 QQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRL 1033
Query: 127 EHYEFQTRQLELKAKN-----------YADQISRLEERE---SEMKKEYNALHQRHTEMI 172
+ Q + E K K+ AD RL + E E++K L +E+
Sbjct: 1034 AEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQ 1093
Query: 173 QTYVEHIERSK 183
+ VE +R++
Sbjct: 1094 EQMVEQQQRAE 1104
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 48.9 bits (115), Expect = 3e-05
Identities = 89/476 (18%), Positives = 186/476 (39%), Gaps = 43/476 (9%)
Query: 49 EEVVKELMPLVVNVLENLDSVLSENQEHEVE-LELLR--EDNEQLLTQYEREKALRRQAE 105
++++ E V+ +E + +E +E E L L R E+ ++ + ER+ R
Sbjct: 1471 DQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAEL 1530
Query: 106 EKFIEFEDALEQEKKELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALH 165
E + +D + + EL+ E L + D+++ E+ + ++ AL
Sbjct: 1531 EALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALK 1590
Query: 166 QRHTEMIQTYVEHIERSKMQQVGGNSQTESSLPGRRKERPTSLNVFPLADGTVRAQIGGK 225
+H +Q E E + Q E RK+R ++ +G + ++ +
Sbjct: 1591 TQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELE-ELKAQ 1649
Query: 226 LVPAGDHWHLSDLGQLQSSSSYQCPQDEMSESGQSSAAATPSTTGTKSNTPTSSVPSAAV 285
+ AG G+ ++ + Q +M E + S S S +
Sbjct: 1650 MASAGQ-------GKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGL 1702
Query: 286 TPLNESLQPLGDYGVGSKNSKRAREKRDSRNMEV--------QVTQEMRNVSIGMGSSDE 337
E L+ + + ++A++ RD EV + +E R + +G +E
Sbjct: 1703 EA--EVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEE 1760
Query: 338 WSDVQDIIDSTPELDMCPETRLDRTGSSPTQGIVNKAFGINTDSLYHELSTAGSEV---I 394
++++ ++ L+ L + S T+ ++F +S +L E+ +
Sbjct: 1761 --ELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRL 1818
Query: 395 GDVDEGADLLGEFSGMGKEVGNLLLENSQLLETKNALNVVKNDLIAKVD--------QLS 446
G+ D GA + + E + L + + LE + ++ L+ + + Q+
Sbjct: 1819 GEEDAGARARHKMTIAALE--SKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVE 1876
Query: 447 GEQEV---LRGELEAAKQAKVKLENRIKELEEELKRVKSEAIIARREPKEEAEDVS 499
E+ V LR +LE +L+ +++E EEE R ++ RR + E EDV+
Sbjct: 1877 EERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQA----GRRRLQRELEDVT 1928
Score = 35.8 bits (81), Expect = 0.28
Identities = 115/585 (19%), Positives = 216/585 (36%), Gaps = 77/585 (13%)
Query: 38 REFERLIHCYDEEVVKELMPLVVNVLENLDSVLSE--NQEHEVELELLREDNE-----QL 90
+E E+L D E EL +V + + + ++ +E E++ L R ++E QL
Sbjct: 1068 QELEKLKRRLDGES-SELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQL 1126
Query: 91 LTQY--------------EREKALRRQAEEKFIEFEDALEQEKKELQIQVEHYEFQTRQL 136
L E E+ R +AE++ + + LE + EL+ ++ Q
Sbjct: 1127 LKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELR 1186
Query: 137 ELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIERSKMQQVGGNSQTESS 196
+ + + LEE + L QRH + + E +E+++ + G +T +
Sbjct: 1187 SKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGK-GAWEKTRLA 1245
Query: 197 LPGRRKERPTSLNVFPLA--DGTVR-----AQIGGKLVPAGDHWHLSDLGQLQSSSSYQC 249
L E L+ A +G R Q+ AGD + + +++ Q
Sbjct: 1246 LEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGD----GERARAEAAEKLQR 1301
Query: 250 PQDEMSE-SGQSSAAATPSTTGTKSNTPTSSVPSAAVTPLNESLQPLGDYGVGSKNSKRA 308
Q E+ SG + A + + +K + T + A L E + +GS+ RA
Sbjct: 1302 AQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETR--AKLALGSR--VRA 1357
Query: 309 REKRDSRNMEVQVTQEM-------RNVSIGMGSSDEWSDVQDIIDSTPELDMCPETRLDR 361
E ++ + Q+ +E R + EW Q+ E R R
Sbjct: 1358 ME-AEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAR 1416
Query: 362 TGSSPTQGIVNKAFGIN-TDSLYHELSTAGSEVIGDVDEGADLLGEFSGMGKEVGNLLLE 420
+ TQ + K ++ + L + D+++ L+ ++ LL E
Sbjct: 1417 EAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAE 1476
Query: 421 NS----QLLETKNALNVVKNDLIAKV--------------DQLSGEQEVLRGELEAAKQA 462
+ +E + + A+ ++L + LR ELEA +
Sbjct: 1477 EKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSS 1536
Query: 463 KVKLENRIKELEEELKRVKSEAIIARREPKEEAEDVSSYLCTESDKIPMAQRRRFTRVEM 522
K + + ELE RV +A R E ED E K+ + + + +
Sbjct: 1537 KDDVGKSVHELERAC-RVAEQAANDLRAQVTELED--ELTAAEDAKLRLEVTVQALKTQH 1593
Query: 523 ARVLMERNQY-KERLMELQEAVRWTEMIRASREHPSVQEKKKSTI 566
R L R++ +ER +L + +R E+ R +E+K+ T+
Sbjct: 1594 ERDLQGRDEAGEERRRQLAKQLRDAEVERD-------EERKQRTL 1631
Score = 35.4 bits (80), Expect = 0.37
Identities = 31/112 (27%), Positives = 53/112 (47%), Gaps = 14/112 (12%)
Query: 79 ELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKELQIQVEHYEFQTRQLEL 138
ELEL+ + E + + E E + + Q E+K L+Q +EL+ +E E ++L+L
Sbjct: 936 ELELVVSELEARVGE-EEECSRQMQTEKK------RLQQHIQELEAHLEAEEGARQKLQL 988
Query: 139 -------KAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIERSK 183
K K + + + LE++ S++ KE L R E E E+ K
Sbjct: 989 EKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVK 1040
Score = 30.8 bits (68), Expect = 9.0
Identities = 34/131 (25%), Positives = 57/131 (43%), Gaps = 21/131 (16%)
Query: 74 QEHEVELELLREDNEQLLTQYEREK----ALRRQAEEKFIEFED---ALEQEKKELQIQV 126
Q+H ELE E E + + EK A ++ EE + ED L +E+K L+ ++
Sbjct: 966 QQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRL 1025
Query: 127 EHYEFQTRQLELKAKN-----------YADQISRLEERE---SEMKKEYNALHQRHTEMI 172
+ Q + E K K+ AD RL + E E++K L +E+
Sbjct: 1026 AEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQ 1085
Query: 173 QTYVEHIERSK 183
+ VE +R++
Sbjct: 1086 EQMVEQQQRAE 1096
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 48.9 bits (115), Expect = 3e-05
Identities = 89/476 (18%), Positives = 186/476 (39%), Gaps = 43/476 (9%)
Query: 49 EEVVKELMPLVVNVLENLDSVLSENQEHEVE-LELLR--EDNEQLLTQYEREKALRRQAE 105
++++ E V+ +E + +E +E E L L R E+ ++ + ER+ R
Sbjct: 1512 DQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAEL 1571
Query: 106 EKFIEFEDALEQEKKELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALH 165
E + +D + + EL+ E L + D+++ E+ + ++ AL
Sbjct: 1572 EALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALK 1631
Query: 166 QRHTEMIQTYVEHIERSKMQQVGGNSQTESSLPGRRKERPTSLNVFPLADGTVRAQIGGK 225
+H +Q E E + Q E RK+R ++ +G + ++ +
Sbjct: 1632 TQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELE-ELKAQ 1690
Query: 226 LVPAGDHWHLSDLGQLQSSSSYQCPQDEMSESGQSSAAATPSTTGTKSNTPTSSVPSAAV 285
+ AG G+ ++ + Q +M E + S S S +
Sbjct: 1691 MASAGQ-------GKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGL 1743
Query: 286 TPLNESLQPLGDYGVGSKNSKRAREKRDSRNMEV--------QVTQEMRNVSIGMGSSDE 337
E L+ + + ++A++ RD EV + +E R + +G +E
Sbjct: 1744 EA--EVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEE 1801
Query: 338 WSDVQDIIDSTPELDMCPETRLDRTGSSPTQGIVNKAFGINTDSLYHELSTAGSEV---I 394
++++ ++ L+ L + S T+ ++F +S +L E+ +
Sbjct: 1802 --ELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRL 1859
Query: 395 GDVDEGADLLGEFSGMGKEVGNLLLENSQLLETKNALNVVKNDLIAKVD--------QLS 446
G+ D GA + + E + L + + LE + ++ L+ + + Q+
Sbjct: 1860 GEEDAGARARHKMTIAALE--SKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVE 1917
Query: 447 GEQEV---LRGELEAAKQAKVKLENRIKELEEELKRVKSEAIIARREPKEEAEDVS 499
E+ V LR +LE +L+ +++E EEE R ++ RR + E EDV+
Sbjct: 1918 EERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQA----GRRRLQRELEDVT 1969
Score = 35.8 bits (81), Expect = 0.28
Identities = 115/585 (19%), Positives = 216/585 (36%), Gaps = 77/585 (13%)
Query: 38 REFERLIHCYDEEVVKELMPLVVNVLENLDSVLSE--NQEHEVELELLREDNE-----QL 90
+E E+L D E EL +V + + + ++ +E E++ L R ++E QL
Sbjct: 1109 QELEKLKRRLDGES-SELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQL 1167
Query: 91 LTQY--------------EREKALRRQAEEKFIEFEDALEQEKKELQIQVEHYEFQTRQL 136
L E E+ R +AE++ + + LE + EL+ ++ Q
Sbjct: 1168 LKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELR 1227
Query: 137 ELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIERSKMQQVGGNSQTESS 196
+ + + LEE + L QRH + + E +E+++ + G +T +
Sbjct: 1228 SKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGK-GAWEKTRLA 1286
Query: 197 LPGRRKERPTSLNVFPLA--DGTVR-----AQIGGKLVPAGDHWHLSDLGQLQSSSSYQC 249
L E L+ A +G R Q+ AGD + + +++ Q
Sbjct: 1287 LEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGD----GERARAEAAEKLQR 1342
Query: 250 PQDEMSE-SGQSSAAATPSTTGTKSNTPTSSVPSAAVTPLNESLQPLGDYGVGSKNSKRA 308
Q E+ SG + A + + +K + T + A L E + +GS+ RA
Sbjct: 1343 AQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETR--AKLALGSR--VRA 1398
Query: 309 REKRDSRNMEVQVTQEM-------RNVSIGMGSSDEWSDVQDIIDSTPELDMCPETRLDR 361
E ++ + Q+ +E R + EW Q+ E R R
Sbjct: 1399 ME-AEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAR 1457
Query: 362 TGSSPTQGIVNKAFGIN-TDSLYHELSTAGSEVIGDVDEGADLLGEFSGMGKEVGNLLLE 420
+ TQ + K ++ + L + D+++ L+ ++ LL E
Sbjct: 1458 EAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAE 1517
Query: 421 NS----QLLETKNALNVVKNDLIAKV--------------DQLSGEQEVLRGELEAAKQA 462
+ +E + + A+ ++L + LR ELEA +
Sbjct: 1518 EKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSS 1577
Query: 463 KVKLENRIKELEEELKRVKSEAIIARREPKEEAEDVSSYLCTESDKIPMAQRRRFTRVEM 522
K + + ELE RV +A R E ED E K+ + + + +
Sbjct: 1578 KDDVGKSVHELERAC-RVAEQAANDLRAQVTELED--ELTAAEDAKLRLEVTVQALKTQH 1634
Query: 523 ARVLMERNQY-KERLMELQEAVRWTEMIRASREHPSVQEKKKSTI 566
R L R++ +ER +L + +R E+ R +E+K+ T+
Sbjct: 1635 ERDLQGRDEAGEERRRQLAKQLRDAEVERD-------EERKQRTL 1672
Score = 35.4 bits (80), Expect = 0.37
Identities = 31/112 (27%), Positives = 53/112 (47%), Gaps = 14/112 (12%)
Query: 79 ELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKELQIQVEHYEFQTRQLEL 138
ELEL+ + E + + E E + + Q E+K L+Q +EL+ +E E ++L+L
Sbjct: 977 ELELVVSELEARVGE-EEECSRQMQTEKK------RLQQHIQELEAHLEAEEGARQKLQL 1029
Query: 139 -------KAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIERSK 183
K K + + + LE++ S++ KE L R E E E+ K
Sbjct: 1030 EKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVK 1081
Score = 30.8 bits (68), Expect = 9.0
Identities = 34/131 (25%), Positives = 57/131 (43%), Gaps = 21/131 (16%)
Query: 74 QEHEVELELLREDNEQLLTQYEREK----ALRRQAEEKFIEFED---ALEQEKKELQIQV 126
Q+H ELE E E + + EK A ++ EE + ED L +E+K L+ ++
Sbjct: 1007 QQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRL 1066
Query: 127 EHYEFQTRQLELKAKN-----------YADQISRLEERE---SEMKKEYNALHQRHTEMI 172
+ Q + E K K+ AD RL + E E++K L +E+
Sbjct: 1067 AEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQ 1126
Query: 173 QTYVEHIERSK 183
+ VE +R++
Sbjct: 1127 EQMVEQQQRAE 1137
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 48.9 bits (115), Expect = 3e-05
Identities = 104/537 (19%), Positives = 207/537 (38%), Gaps = 50/537 (9%)
Query: 67 DSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKELQIQV 126
D L +N +V EL + E L +E EKA R +AE++ + + LE K EL+ +
Sbjct: 1101 DETLHKNNALKVVRELQAQIAE-LQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTL 1159
Query: 127 EHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIERSKMQQ 186
+ Q + + A+ LEE + + + QRH ++ E +E++K +
Sbjct: 1160 DTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFK 1219
Query: 187 VGGNSQTESSLPGRRKERPTSLNVFPLADGT---VRAQIGGKLVPAGDHWHLSDLGQLQS 243
+ + L KE + V R ++ ++ H +S+ +L+
Sbjct: 1220 -ANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQEL--HAKVSEGDRLRV 1276
Query: 244 SSSYQCPQDEMSESGQSSAAATPSTTGTKSNTPTSSVPSAAVTPLNESLQPLGDYGVGSK 303
+ + + + S+ G K +S+ S L ++ + L +
Sbjct: 1277 ELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLES----QLQDTQELLQEETRQKL 1332
Query: 304 N-SKRAREKRDSRNM---------EVQVTQEMRNVSIGMGSSDEWSDVQDIIDSTPELDM 353
N S R R+ + +N E + E + +++ +D V D + + L+
Sbjct: 1333 NLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEE 1392
Query: 354 CPETRLDRTGSSPTQGIVNKAFGIN-TDSLYHELSTAGSEVIGDVDEGADLLGEFSGMGK 412
+ +L + + +Q + KA + + + L ++ D+D + K
Sbjct: 1393 A-KKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQK 1451
Query: 413 EVGNLLLENSQL-----------------LETKNALNVVK--NDLIAKVDQLSGEQEVLR 453
+ LL E + ETK AL++ + + + ++ + + LR
Sbjct: 1452 KFDQLLAEEKSISARYAEERDRAEAEAREKETK-ALSLARALEEALEAKEEFERQNKQLR 1510
Query: 454 GELEAAKQAKVKLENRIKELEEELKRVKSEAIIARREPKEEAEDVSSYLCTESDKIPMAQ 513
++E +K + + ELE+ KR + + R EE ED TE K+ +
Sbjct: 1511 ADMEDLMSSKDDVGKNVHELEKS-KRALEQQVEEMRTQLEELED--ELQATEDAKLRLEV 1567
Query: 514 RRRFTRVEMARVLM---ERNQYKERLMELQEAVRWTEMIRASREHP-SVQEKKKSTI 566
+ + + R L E+N+ K+RL+ Q E+ ++ +V KKK I
Sbjct: 1568 NMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEI 1624
Score = 48.1 bits (113), Expect = 5e-05
Identities = 101/535 (18%), Positives = 204/535 (38%), Gaps = 66/535 (12%)
Query: 41 ERLIHCYDEEV--VKELMPLVVNVLENLD----------SVLSENQEHEVELELLREDNE 88
E + DEE+ VKE V LE ++ ++L+E + E EL E+
Sbjct: 851 EEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMR 910
Query: 89 QLLTQYERE-KALRRQAEEKFIEFEDA---LEQEKKELQIQVEHYEFQTRQ--------- 135
L ++E + + E + E E+ L+ EKK++Q ++ E Q +
Sbjct: 911 ARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQ 970
Query: 136 -----LELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIERSKMQQVGGN 190
E K K ++I LE++ S+ KE + R E E E++K N
Sbjct: 971 LEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRN 1030
Query: 191 SQTE--SSLPGRRKERPTSLNVFPLADGTVRAQIGGKLVPAGDHWHLSDLGQLQSS-SSY 247
Q S L R K+ + A + ++ G+ D + +LQ+
Sbjct: 1031 KQEVMISDLEERLKKEEKTRQELEKA----KRKLDGETTDLQD-----QIAELQAQIDEL 1081
Query: 248 QCPQDEMSESGQSSAAATPSTTGTKSNTPTSSVPSAAVTPLNESLQPLGDYGVGSKNSKR 307
+ + E Q + A T K+N A+ + E + + ++ K
Sbjct: 1082 KLQLAKKEEELQGALARGDDETLHKNN---------ALKVVRELQAQIAELQEDFESEKA 1132
Query: 308 AREKRDSRNMEVQVTQEMRNVSIGMGSSDEWSDVQDIIDSTPELDMCPETRLDRTGSSPT 367
+R K + + + +++E+ + ++++D +D+T E R R
Sbjct: 1133 SRNKAEKQKRD--LSEELEALK---------TELEDTLDTTAAQQ---ELRTKREQEVAE 1178
Query: 368 QGIVNKAFGINTDSLYHELSTAGSEVIGDVDEGADLLGEF-SGMGKEVGNLLLENSQLLE 426
+ N ++ ++ + + ++ E + F + + K L +N +L
Sbjct: 1179 LKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELAC 1238
Query: 427 TKNALNVVKNDLIAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELEEELKRVKSEAII 486
L VK + K +L + + L ++ + +V+L + +L+ EL V +
Sbjct: 1239 EVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEE 1298
Query: 487 ARREPKEEAEDVSSYLCTESDKIPMAQRRRFTRVEMARVLMERNQYKERLMELQE 541
A ++ + A+D +S D + Q ++ ++ + + + K L E QE
Sbjct: 1299 AEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQE 1353
Score = 42.7 bits (99), Expect = 0.002
Identities = 96/485 (19%), Positives = 188/485 (38%), Gaps = 61/485 (12%)
Query: 49 EEVVKELMPLVVNVLENLDSVLSENQEHEVELELLREDNEQLLT---QYERE-KALRRQA 104
++++ E + E D +E +E E + L E+ L ++ER+ K LR
Sbjct: 1454 DQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADM 1513
Query: 105 EEKFIEFEDA------LEQEKKELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMK 158
E+ +D LE+ K+ L+ QVE Q +LE D++ E+ + ++
Sbjct: 1514 EDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELE-------DELQATEDAKLRLE 1566
Query: 159 KEYNALHQRHTEMIQTYVEHIERSKMQQVGGNSQTESSLPGRRKERPTSL-----NVFPL 213
A+ + +QT E E K + + E+ L RK+R ++ L
Sbjct: 1567 VNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDL 1626
Query: 214 ADGTVRAQIGGKLVPAGDHWHLSDLGQLQSSSSYQCPQDEMSESGQSSAAATPSTTGTKS 273
D + + K A D + L +LQ+ +D E ++ A+ +K
Sbjct: 1627 KDLEAQIEAANK---ARDE-VIKQLRKLQAQM-----KDYQRELEEARASRDEIFAQSKE 1677
Query: 274 NTPTSSVPSAAVTPLNESLQPLGDYGVGSKNSKR-AREKRDSRNMEV--------QVTQE 324
+ A + L E L S+ ++R A ++RD E+ + E
Sbjct: 1678 SEKKLKSLEAEILQLQEEL-------ASSERARRHAEQERDELADEITNSASGKSALLDE 1730
Query: 325 MRNVSIGMGSSDEWSDVQDIIDSTPEL--DMCPETRLDRTGSSPTQGIVNKAFGINTDSL 382
R + + +E + + S EL D +T L + + + ++ +D+
Sbjct: 1731 KRRLEARIAQLEEELEEE---QSNMELLNDRFRKTTL-QVDTLNAELAAERSAAQKSDNA 1786
Query: 383 YHELSTAGSEVIGDVDE-----GADLLGEFSGMGKEVGNLLLENSQLLETKNALNVVKND 437
+L E+ + E + S + ++G L + Q + + A N +
Sbjct: 1787 RQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRR 1846
Query: 438 LIAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELEEELKRVKSEAIIA---RREPKEE 494
K+ ++ + E R + K+ K R+K+L+ +L+ + EA A RR+ + E
Sbjct: 1847 TEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRE 1906
Query: 495 AEDVS 499
+D +
Sbjct: 1907 LDDAT 1911
Score = 35.0 bits (79), Expect = 0.48
Identities = 36/130 (27%), Positives = 64/130 (49%), Gaps = 12/130 (9%)
Query: 420 ENSQLLET-KNALNVVKNDLIAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELEEE-- 476
E +Q+L+ K + DL ++D+ G ++ L+ E KV E +IK++EEE
Sbjct: 936 ERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLE-------KVTAEAKIKKMEEEIL 988
Query: 477 -LKRVKSEAIIARREPKEEAEDVSSYLCTESDKIPMAQRRRFTRVEMARVLMERNQYKER 535
L+ S+ I ++ ++ + SS L E +K + R + M L ER + +E+
Sbjct: 989 LLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEK 1048
Query: 536 L-MELQEAVR 544
EL++A R
Sbjct: 1049 TRQELEKAKR 1058
Score = 33.9 bits (76), Expect = 1.1
Identities = 43/201 (21%), Positives = 83/201 (41%), Gaps = 30/201 (14%)
Query: 385 ELSTAGSEVIGDVDEGADLLGEFSGMGKEVGNLLLENSQLLETKNALN----VVKNDLIA 440
EL A ++ G+ + D + E E+ L + + L+ A + KN+ +
Sbjct: 1052 ELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALK 1111
Query: 441 KVDQLSGEQEVLRGELEAAKQAKVKLENRIKELEEELKRVKSE------AIIARREPKEE 494
V +L + L+ + E+ K ++ K E + ++L EEL+ +K+E A++E + +
Sbjct: 1112 VVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTK 1171
Query: 495 AEDVSSYLCT---------ESDKIPMAQRRRFTRVEMARVLMERNQYKERL--------- 536
E + L E+ M QR E++ L + ++K L
Sbjct: 1172 REQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLET 1231
Query: 537 --MELQEAVRWTEMIRASREH 555
EL V+ + ++A EH
Sbjct: 1232 DNKELACEVKVLQQVKAESEH 1252
Score = 33.5 bits (75), Expect = 1.4
Identities = 49/207 (23%), Positives = 88/207 (42%), Gaps = 38/207 (18%)
Query: 385 ELSTAGSEVIGDVDEGADLLGEFSGMGKEVG----NLLLENSQLLETKNALNVVKNDLIA 440
E T + ++E + EF K++ +L+ + + + L K L
Sbjct: 1480 EKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQ 1539
Query: 441 KVDQLSGEQEVLRGELEAAKQAKVKLENRIKELEEELKR----------VKSEAIIAR-R 489
+V+++ + E L EL+A + AK++LE ++ ++ + +R K +I + R
Sbjct: 1540 QVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVR 1599
Query: 490 EPKEEAED--------VSSYLCTESD------KIPMAQRRRFTRVEMARVLMERNQYKER 535
E + E ED V+S E D +I A + R ++ R L + Q K+
Sbjct: 1600 ELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKL--QAQMKDY 1657
Query: 536 LMELQEAVRWTEMIRASREHPSVQEKK 562
EL+EA RASR+ Q K+
Sbjct: 1658 QRELEEA-------RASRDEIFAQSKE 1677
Score = 33.1 bits (74), Expect = 1.8
Identities = 96/501 (19%), Positives = 193/501 (38%), Gaps = 50/501 (9%)
Query: 48 DEEVVKELMPLVVNVLENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEK 107
+EE K L V+ + L + + +E L E ++LL E AL ++ EEK
Sbjct: 1355 EEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAE---ALSQRLEEK 1411
Query: 108 FIEFEDALEQEKKELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQR 167
+ + D LE+ K LQ +++ L + + S LE+++ K+++ L
Sbjct: 1412 ALAY-DKLEKTKNRLQQELD-------DLTVDLDHQRQVASNLEKKQ----KKFDQLLAE 1459
Query: 168 HTEMIQTYVEHIERSKMQQVGGNSQTES-SLPGRRKERPTSLNVFPLADGTVRAQIGGKL 226
+ Y E ER + + +T++ SL +E + F + +RA + +
Sbjct: 1460 EKSISARYAE--ERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLM 1517
Query: 227 VPAGDHWHLSDLGQLQSSS-SYQCPQDEMSESGQSSAAATPSTTGTKSNTPTSSVPSAAV 285
D ++ +L+ S + + +EM + +T K + A
Sbjct: 1518 SSKDDVG--KNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNM--QAMK 1573
Query: 286 TPLNESLQPLGDYGVGSKNSKRAREKRDSRNMEVQVTQEMRNVSIGMGSSDEWS-DVQDI 344
LQ + ++ KR K+ R +E ++ E + ++ + S + D++D+
Sbjct: 1574 AQFERDLQTRDEQ---NEEKKRLLIKQ-VRELEAELEDERKQRALAVASKKKMEIDLKDL 1629
Query: 345 IDSTPELDMCPETRLDRTGSSPTQGIVN-KAFGINTDSLYHELSTAGSEVIGDVDEGADL 403
E +++ + + I + EL A + ++
Sbjct: 1630 -----------EAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARAS-------RDEI 1671
Query: 404 LGEFSGMGKEVGNLLLENSQLLETKNALNVVKNDLIAKVDQLSGEQEVLRGELEAAKQAK 463
+ K++ +L E QL E + + + D+L+ E A K
Sbjct: 1672 FAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEK 1731
Query: 464 VKLENRIKELEEELKRVKSEAIIARREPKEEAEDVSSYLCTESDKIPMAQRRRFTRVEMA 523
+LE RI +LEEEL+ +S + ++ V + + + AQ+ R ++
Sbjct: 1732 RRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLE 1791
Query: 524 RVLMERNQYKERLMELQEAVR 544
R + + K +L EL+ AV+
Sbjct: 1792 R---QNKELKAKLQELEGAVK 1809
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 47.8 bits (112), Expect = 7e-05
Identities = 105/527 (19%), Positives = 213/527 (40%), Gaps = 60/527 (11%)
Query: 49 EEVVKELMPLVVNVLENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKF 108
EE K+L + E +++V ++ E L+ + E L+ ER A ++K
Sbjct: 1387 EEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQ 1446
Query: 109 IEFEDAL---EQEKKELQIQVEHYEFQTRQLE---LKAKN-YADQISRLE--ERESE-MK 158
F+ L +Q+ +E Q ++E + + R L K KN Y + + LE +RE++ ++
Sbjct: 1447 RNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQ 1506
Query: 159 KEYNALHQRHTEMIQTYVE------HIERSKMQQVGGNSQTESSLPGRRKERPTSLNVFP 212
+E + L ++ +T E +E KM+ + E+SL + +
Sbjct: 1507 EEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASL----EHEEGKILRAQ 1562
Query: 213 LADGTVRAQIGGKLVPAGDHWHLSDLGQLQSSSSYQCPQDEMSESGQSSAAATPSTTGTK 272
L ++A+I KL + + L+ S Q D + S + G
Sbjct: 1563 LEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDL 1622
Query: 273 SNTPT----SSVPSAAVTPLNESLQPL-GDYGVGSKNSKRAREKRDSRNMEVQVTQEMRN 327
+ ++ +A +SLQ L D + ++ RA D + + + N
Sbjct: 1623 NEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRAN---DDLKENIAIVERRNN 1679
Query: 328 VSIGMGSSDEWSDVQDIIDSTPELDMCPETRLDRTGS------SPTQGIVNKAFGINTD- 380
+ E +++ +++ T E L T S ++N+ ++ D
Sbjct: 1680 LL-----QAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADL 1734
Query: 381 -SLYHELSTAGSEVIGDVDEGADLLGEFSGMGKEVGNLLLENSQLLETKNALNVVKNDLI 439
L E+ A E ++ + + + M +E+ ++ L K + DL
Sbjct: 1735 SQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQ 1794
Query: 440 AKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELEEEL---KRVKSEAIIARREPKEEAE 496
++D+ EQ L+G K+ KLE R++ELE EL ++ +E++ R+ + +
Sbjct: 1795 HRLDE--AEQIALKG----GKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIK 1848
Query: 497 DVSSYLCTESDKIPMAQRRRFTRVE--MARVLMERNQYKERLMELQE 541
+++ TE D R+ R++ + ++ ++ YK + E +E
Sbjct: 1849 ELTYQ--TEED------RKNLLRLQDLVDKLQLKVKAYKRQAEEAEE 1887
Score = 42.0 bits (97), Expect = 0.004
Identities = 101/514 (19%), Positives = 199/514 (38%), Gaps = 70/514 (13%)
Query: 49 EEVVKELMPLVVNVLENLDSVLSEN----QEHEVELELLREDNEQLLTQYEREKALRRQA 104
E VK L + + E + + E + H+ L+ L+ + +++ T + + L +Q
Sbjct: 972 ENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQV 1031
Query: 105 EEKFIEFEDALEQEKK---ELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEY 161
++ E +LEQEKK +L+ E + + + + +L+ER + E
Sbjct: 1032 DD----LEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFEL 1087
Query: 162 NALHQRHTEMIQTYVEHIERSKMQQVGGNSQTESSLPGRRKERPTSLNVFPLADGTVRA- 220
NAL+ R E Q +++ + + E L R R V L R
Sbjct: 1088 NALNAR-IEDEQALGSQLQKKLKELQARIEELEEELEAERTARA---KVEKLRSDLSREL 1143
Query: 221 -QIGGKLVPAGDHWHLSDLGQLQSSSSYQCPQDEMSESGQSSAAATPSTTGTKSNTPTSS 279
+I +L AG + Q++ + + +M + + +T S
Sbjct: 1144 EEISERLEEAGGATSV----QIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADS 1199
Query: 280 VPSAAVTPLNESLQPLGDYGVGSKNSKRAREKRDSRNMEVQVTQEMRNVSIGMGSSDEWS 339
V + G N +R ++K + E ++ + D S
Sbjct: 1200 V---------------AELGEQIDNLQRVKQKLEKEKSEFKLELD-----------DVTS 1233
Query: 340 DVQDIIDSTPELDMCPETRLD-----RTGSSPTQGIVNKAFGINTDSLYHELSTAGSEVI 394
+++ II + L+ T D R+ + TQ VN + S +L T E+
Sbjct: 1234 NMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVN-----DLTSQRAKLQTENGELS 1288
Query: 395 GDVDEGADLLGEFSGMGKEVGNLLLENSQLLETKNALNV---VKNDLIAKVDQLSGEQEV 451
+DE L+ + + GK L QL + K L KN L + + ++
Sbjct: 1289 RQLDEKEALISQLT-RGK-----LTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDL 1342
Query: 452 LRGELEAAKQAKVKLENRIKELEEELK--RVKSEA-IIARREPKEEAEDVSSYLCTESDK 508
LR + E +AK +L+ + + E+ R K E I R E EEA+ + E+++
Sbjct: 1343 LREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEE 1402
Query: 509 IPMAQRRRFTRVEMARVLMERNQYKERLMELQEA 542
A + + +E + ++ N+ ++ +++++ +
Sbjct: 1403 AVEAVNAKCSSLEKTKHRLQ-NEIEDLMVDVERS 1435
Score = 42.0 bits (97), Expect = 0.004
Identities = 44/167 (26%), Positives = 79/167 (47%), Gaps = 20/167 (11%)
Query: 33 AGSIYREFERLIHCYDEEVVKELMPLVVNVLENLDSVLSENQEHEVELELLRED-NEQLL 91
A S+ E +L + Y+E LE+L++ EN+ + E+ L E
Sbjct: 1474 ARSLSTELFKLKNAYEES------------LEHLETFKRENKNLQEEISDLTEQLGSSGK 1521
Query: 92 TQYEREKALRRQAEEKFIEFEDALEQEKKELQIQVEHYEFQTRQLELKAKNYADQISR-L 150
T +E EK +R+Q E + +E + ALE E + +EH E + + +L+ +I R L
Sbjct: 1522 TIHELEK-VRKQLEAEKMELQSALE----EAEASLEHEEGKILRAQLEFNQIKAEIERKL 1576
Query: 151 EERESEMKKEYNALHQRHTEMIQTYVEHIERSKMQQVGGNSQTESSL 197
E++ EM ++ H R + +QT ++ RS+ + + + E L
Sbjct: 1577 AEKDEEM-EQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDL 1622
Score = 38.5 bits (88), Expect = 0.043
Identities = 45/204 (22%), Positives = 90/204 (44%), Gaps = 26/204 (12%)
Query: 26 SERVSGLAGSIYREFERLIHCYDEEVV--KELMPLVVNVLENLDSVLSENQEHEVELELL 83
+ER +A S+ EF RL ++ KEL +V++L+ + + + Q + L
Sbjct: 843 AEREKEMA-SMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADA 901
Query: 84 REDNEQLLTQYEREKALRRQAEEKFIEFEDA----------LEQEKKELQIQVEHYEFQT 133
E +QL+ + +A ++ E+ + E+ LE E EL+ ++ E
Sbjct: 902 EERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTL 961
Query: 134 RQLEL-------KAKNYADQISRLEERESEMKKEYNALHQRHTEMI------QTYVEHIE 180
++E K KN ++++ L+E +++ KE AL + H + + + V +
Sbjct: 962 AKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLT 1021
Query: 181 RSKMQQVGGNSQTESSLPGRRKER 204
++K++ E SL +K R
Sbjct: 1022 KAKVKLEQQVDDLEGSLEQEKKVR 1045
Score = 38.5 bits (88), Expect = 0.043
Identities = 45/200 (22%), Positives = 87/200 (43%), Gaps = 35/200 (17%)
Query: 16 QDDYCSGSVMSERVSGLAGSIYR-----EFERLIHCYDEEVVKELMPLVVNVLENLDSV- 69
+D+ GS + +++ L I E ER E++ +L + + E L+
Sbjct: 1095 EDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAG 1154
Query: 70 ------LSENQEHEVELELLREDNEQLLTQYE-REKALRRQAEEKFIEF----------E 112
+ N++ E E + +R D E+ Q+E ALR++ + E +
Sbjct: 1155 GATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVK 1214
Query: 113 DALEQEKKELQIQVEHYEFQTRQLELKAKNYADQISR-LEERESEMKKEYNALHQRHTEM 171
LE+EK E +++++ Q+ +KAK +++ R LE++ +E H+ E
Sbjct: 1215 QKLEKEKSEFKLELDDVTSNMEQI-IKAKANLEKMCRTLEDQMNE--------HRSKAEE 1265
Query: 172 IQTYVEHI--ERSKMQQVGG 189
Q V + +R+K+Q G
Sbjct: 1266 TQRSVNDLTSQRAKLQTENG 1285
Score = 36.2 bits (82), Expect = 0.22
Identities = 46/199 (23%), Positives = 86/199 (43%), Gaps = 26/199 (13%)
Query: 380 DSLYHELSTAGSEVIGDVDEGADLLGEFSGMGKEVGNLLLENSQLLETKNALNVVKNDLI 439
D L L+ E ++ +L E +G+ + + L E L E
Sbjct: 955 DDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQA-------- 1006
Query: 440 AKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELEEELKRVKSEAIIARREPKEEAEDV- 498
+D L E++ ++ +AKVKLE ++ +LE L++ K + R ++ D+
Sbjct: 1007 --LDDLQAEED----KVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLK 1060
Query: 499 ---SSYLCTESDKIPMAQRRRFTRVEM----ARVLMER---NQYKERLMELQEAV-RWTE 547
S + E+DK + +R + E+ AR+ E+ +Q +++L ELQ + E
Sbjct: 1061 LTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEE 1120
Query: 548 MIRASREHPSVQEKKKSTI 566
+ A R + EK +S +
Sbjct: 1121 ELEAERTARAKVEKLRSDL 1139
Score = 30.8 bits (68), Expect = 9.0
Identities = 34/159 (21%), Positives = 62/159 (38%), Gaps = 11/159 (6%)
Query: 406 EFSGMGKEVGNLLLENSQLLETKNALNVVKNDLIAKVDQLSGEQEVLRGELEAAKQAKVK 465
EF+ + E+ L E + +E K + + VD L + A + K K
Sbjct: 1564 EFNQIKAEIERKLAEKDEEMEQ------AKRNHLRVVDSLQTSLDAETRSRNEALRVKKK 1617
Query: 466 LENRIKELEEELKRVKSEAIIARREPKEEAEDVSSYLCTESDKIPMAQRRRFTRVEMARV 525
+E + E+E +L A E +++ + + S L ++ A R E +
Sbjct: 1618 MEGDLNEMEIQLSHANRMA----AEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAI 1673
Query: 526 LMERNQ-YKERLMELQEAVRWTEMIRASREHPSVQEKKK 563
+ RN + L EL+ V TE R E ++ ++
Sbjct: 1674 VERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSER 1712
>gi|215982794 myosin VA isoform 2 [Homo sapiens]
Length = 1828
Score = 47.4 bits (111), Expect = 9e-05
Identities = 45/213 (21%), Positives = 94/213 (44%), Gaps = 33/213 (15%)
Query: 27 ERVSGLAGSIYREFERL------IHCYDEEV------VKELMPLVVNVLENLDSVLSENQ 74
E+++ L G E E+L + +EE V L + + ++L+ SE +
Sbjct: 948 EKLTNLEGIYNSETEKLRSDLERLQLSEEEAKVATGRVLSLQEEIAKLRKDLEQTRSEKK 1007
Query: 75 EHEVELELLREDNEQLLTQYEREKALRRQAEEKFI-----EFEDALEQEKKELQIQVEHY 129
E + +++ EQL++ + E L +Q +E + ++ E +K+L + +
Sbjct: 1008 CIEEHADRYKQETEQLVSNLKEENTLLKQEKEALNHRIVQQAKEMTETMEKKLVEETKQL 1067
Query: 130 EFQTRQLELKAKNYADQISRLEERESEMKKEYNAL-------HQR----HTEMIQTYVEH 178
E L+ +N ++ SRLEER ++K+E + H+R H+ Y+
Sbjct: 1068 ELDLNDERLRYQNLLNEFSRLEERYDDLKEEMTLMVHVPKPGHKRTDSTHSSNESEYIFS 1127
Query: 179 IERSKMQQVGGNSQTESSLPGRRKERPTSLNVF 211
E ++M+ + ++ S K+ P +++F
Sbjct: 1128 SEIAEMEDIPSRTEEPS-----EKKVPLDMSLF 1155
>gi|215982791 myosin VA isoform 1 [Homo sapiens]
Length = 1855
Score = 47.4 bits (111), Expect = 9e-05
Identities = 45/213 (21%), Positives = 94/213 (44%), Gaps = 33/213 (15%)
Query: 27 ERVSGLAGSIYREFERL------IHCYDEEV------VKELMPLVVNVLENLDSVLSENQ 74
E+++ L G E E+L + +EE V L + + ++L+ SE +
Sbjct: 948 EKLTNLEGIYNSETEKLRSDLERLQLSEEEAKVATGRVLSLQEEIAKLRKDLEQTRSEKK 1007
Query: 75 EHEVELELLREDNEQLLTQYEREKALRRQAEEKFI-----EFEDALEQEKKELQIQVEHY 129
E + +++ EQL++ + E L +Q +E + ++ E +K+L + +
Sbjct: 1008 CIEEHADRYKQETEQLVSNLKEENTLLKQEKEALNHRIVQQAKEMTETMEKKLVEETKQL 1067
Query: 130 EFQTRQLELKAKNYADQISRLEERESEMKKEYNAL-------HQR----HTEMIQTYVEH 178
E L+ +N ++ SRLEER ++K+E + H+R H+ Y+
Sbjct: 1068 ELDLNDERLRYQNLLNEFSRLEERYDDLKEEMTLMVHVPKPGHKRTDSTHSSNESEYIFS 1127
Query: 179 IERSKMQQVGGNSQTESSLPGRRKERPTSLNVF 211
E ++M+ + ++ S K+ P +++F
Sbjct: 1128 SEIAEMEDIPSRTEEPS-----EKKVPLDMSLF 1155
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 47.4 bits (111), Expect = 9e-05
Identities = 54/248 (21%), Positives = 103/248 (41%), Gaps = 16/248 (6%)
Query: 416 NLLLENSQLLETKNALNVVKNDLIAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELEE 475
NL EN +L+E +L K + ++ + G+L + K+ +I++LE+
Sbjct: 64 NLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKK-------QIEKLEQ 116
Query: 476 ELKRVKSEAIIARREPKEEAEDVSSYLCTESDKI---PMAQRRRFTRVEMARVLMERNQY 532
ELKR KSE + R + ++ DVS C KI P+ + ++ + + + N+
Sbjct: 117 ELKRCKSE--LERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKE 174
Query: 533 KERLMELQEAVRWTEMIRASREHP-SVQEKKKSTIWQFFSRLFSSSSSPPPAKRPYPSVN 591
E L+ V+ + +AS+ P + + Q S +FS P+ S
Sbjct: 175 VEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQR 234
Query: 592 IHYKSPTTAGF---SQRRNHAMCPISAGSRPLEFFPDDDCTSSARREQKREQYRQVREHV 648
+ +A + Q + + G R D+ +S +Q + Q +++R +
Sbjct: 235 TPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKI 294
Query: 649 RNDDGRLQ 656
+ RLQ
Sbjct: 295 NELELRLQ 302
Score = 46.6 bits (109), Expect = 2e-04
Identities = 111/554 (20%), Positives = 217/554 (39%), Gaps = 77/554 (13%)
Query: 64 ENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKELQ 123
ENL + L + QE ELE++ E +L + E+EK Q +EK + L+ + KEL
Sbjct: 2395 ENLTNELQKEQERISELEIINSSFENILQEKEQEKV---QMKEKSSTAMEMLQTQLKELN 2451
Query: 124 IQVEHYEFQTRQLELKAKNYADQISRLEERES-------EMKKEYNALHQRHTEMIQTYV 176
+V + K +N + Q+ LE ++ E K Y L +IQ
Sbjct: 2452 ERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVE 2511
Query: 177 ----------EHIER------------SKMQQVGGNSQ--TESSLPGRRKERPTSLNVFP 212
E I R SK+ QV G Q E +L R +
Sbjct: 2512 DGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQV 2571
Query: 213 LADGTVRAQIGGKLVPAG-----DHWHLSDLGQL-------QSSSSYQCPQDEMSESGQS 260
L Q +++ + + L+ + ++ + ++ Q EM E Q
Sbjct: 2572 LQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQK 2631
Query: 261 SAAATPSTTGTKSNTPTSSVPSAAVTPLNESLQPLGDYGVGSKNSKRARE--KRDSRNME 318
+A +G K+ + + + S L + + + K++ + +D E
Sbjct: 2632 TAELQEELSGEKNR--LAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKE 2689
Query: 319 VQVTQEMRNVSIGMGSSDEWSDVQDIIDSTPELDMCPETRLDRTGSSPTQGIVNKAFGIN 378
+V +E+ + + +++ ++D+ + ++ +T ++ + +K ++
Sbjct: 2690 GKVREEIAEYQLRLHEAEKKHQAL-LLDTNKQYEVEIQTYREK--------LTSKEECLS 2740
Query: 379 TDSLYHELSTAGSEVIGD-VDEGADLLGEFSGMGKEVGNLLLENSQLLETKNALNVVKND 437
+ L +L + E + + + +L E ++ NL N E + A +K
Sbjct: 2741 SQKLEIDLLKSSKEELNNSLKATTQILEELK--KTKMDNLKYVNQLKKENERAQGKMKL- 2797
Query: 438 LIAKVDQLSGEQEVLRGELEAAKQAKVK------LENRIKELEEELKRVKSEAIIARREP 491
LI QL E+E+L+ EL + A+ K ++ ++ EL E+K +K E + + +
Sbjct: 2798 LIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELK-ETLEEKTKE 2856
Query: 492 KEEAEDVSSYLCTESDKIPMAQRRRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRA 551
+E D L +K+ A+ T+V A + ++++ R L V +
Sbjct: 2857 ADEYLDKYCSLLISHEKLEKAKEMLETQV--AHLCSQQSKQDSRGSPLLGPV-----VPG 2909
Query: 552 SREHPSVQEKKKST 565
PSV EK+ S+
Sbjct: 2910 PSPIPSVTEKRLSS 2923
Score = 45.1 bits (105), Expect = 5e-04
Identities = 101/506 (19%), Positives = 205/506 (40%), Gaps = 49/506 (9%)
Query: 67 DSVLSENQEHEVELELLREDNEQLLTQYEREKA----LRRQAEE-----KFIEFE-DALE 116
DS+ + + E EL++ E+ E ++ E KA L+ Q EE K E + L
Sbjct: 2150 DSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLR 2209
Query: 117 QEKKELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYV 176
EK+ L Q++ + Q +L+ ++ + E+ E ++K+E + EM+Q +
Sbjct: 2210 SEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEE----SKTAVEMLQNQL 2265
Query: 177 EHIERSKMQQVGGN---SQTESSLPGRRKERPTSLNVFPLADGTVRAQIGGKLV---PAG 230
+ + + G TE SL +E N + A +L
Sbjct: 2266 KELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLK 2325
Query: 231 DHWHLSDL--GQLQSSSSYQCPQDEMSESGQSSAAATPSTTGTKSNTPTSSVPSAAVTPL 288
+ H +DL G++++ + E++ + Q AA + + T A + +
Sbjct: 2326 ESEHHADLLKGRVENLER----ELEIARTNQEHAALEAENSKGEVET-----LKAKIEGM 2376
Query: 289 NESLQPLGDYGVGSKNSKRAREKRDSRNMEVQVTQEMRNVSI-GMGSSDEWSDVQDIIDS 347
+SL+ L V ++ K + E E+ N S + E VQ S
Sbjct: 2377 TQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKS 2436
Query: 348 TPELDMCPETRL----DRTGSSPTQGIVNKAFGINTDSLYHELSTAGSEVIGDVDEGAD- 402
+ ++M +T+L +R + KA N S L ++++ +DE +
Sbjct: 2437 STAMEML-QTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNN 2495
Query: 403 ---LLGEFSGMGKEV--GNLLLE--NSQLLETKNALNVVKNDLIAKVDQLSGEQEVLRGE 455
L +G+ +EV G LE + ++ KN + + L++K+ Q+ GE ++ + +
Sbjct: 2496 YIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQ-DQEQLVSKLSQVEGEHQLWKEQ 2554
Query: 456 LEAAKQAKVKLENRIKELEEELKRVKSEAIIARREPKEEAEDVSSYLCTESDKIPMAQRR 515
+ V+LE +I+ L+ + ++ + + K ++ T+ DK+ ++
Sbjct: 2555 NLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELE---LTKMDKMSFVEKV 2611
Query: 516 RFTRVEMARVLMERNQYKERLMELQE 541
+ + E ++ ++ ELQE
Sbjct: 2612 NKMTAKETELQREMHEMAQKTAELQE 2637
Score = 39.3 bits (90), Expect = 0.025
Identities = 38/187 (20%), Positives = 79/187 (42%), Gaps = 22/187 (11%)
Query: 35 SIYREFERLIHCYDEEVVKELMPLVVNVLE---NLDSVLSENQEHEVE-----LELLRED 86
++ R+ + I+ + + E + L V LE + L + +EH +E L ++
Sbjct: 535 TMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKE 594
Query: 87 NEQLLTQYEREKALRRQAEEKFIEFE----------DALEQEKKELQIQVEHYEFQTRQL 136
++ LL+ E +K + +E+ F +E EK+ LQ ++ H E +
Sbjct: 595 SKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQ 654
Query: 137 ELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIERSKMQQVGGNSQTESS 196
++K+ Y +++ LE + E LH ++ + +E K+ + + E S
Sbjct: 655 QIKSHEYNERVRTLEMDRENLSVEIRNLH----NVLDSKSVEVETQKLAYMELQQKAEFS 710
Query: 197 LPGRRKE 203
+KE
Sbjct: 711 DQKHQKE 717
Score = 38.1 bits (87), Expect = 0.057
Identities = 101/517 (19%), Positives = 196/517 (37%), Gaps = 85/517 (16%)
Query: 95 EREKALRRQAEEKFIEFE---DALEQEKKELQIQVEHYEFQTRQLELKAKNYADQ---IS 148
E ++ L +A +K E E D L++EK++ Q Q++ E ++ + K +N + +
Sbjct: 7 EWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLK 66
Query: 149 RLEERESEMKKEYNALHQRHTEMIQTYVEHIERSKMQQVGGNSQTESSLPGRRKERPTSL 208
R +R E+ + Q+ + +Q + + Q G Q E L K + L
Sbjct: 67 RENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEK-LEQELKRCKSEL 125
Query: 209 NVFPLADGTVRAQIGGKLVPAGDHWHLSDLGQLQSSSSYQCPQDEMSESGQSSAAATPST 268
A + + P Q S S Y+ +++ ++ +
Sbjct: 126 ERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEV 185
Query: 269 TGTKSNTPTSSVPSAAVTPLNESLQPLGDYGVG----------SKNSKRAREKRDSRNME 318
++ + ++P A + + + S NS+R +RD
Sbjct: 186 KALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASY 245
Query: 319 VQVTQEMR--NVSIGMGSSDEWSDVQDIIDSTPELDMCPETRLDRTGSSPTQGIVNKAFG 376
QE+ ++ +G D S D S LD + Q + NK
Sbjct: 246 FSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQL---------KAQNQELRNKINE 296
Query: 377 INTDSLYHELSTAGSEVIGDVDEGADLLGEFSGMGKEVGNLLLENS--QLLETKNALNVV 434
+ HE E+ G V++ +L L LE + +L+E + LN
Sbjct: 297 LELRLQGHE-----KEMKGQVNKFQEL------------QLQLEKAKVELIEKEKVLNKC 339
Query: 435 KNDLI---AKVDQLSGEQEVLRGELEA-----------AKQAKVKLENRIKELE----EE 476
+++L+ A+ DQ S + L +L+ A+ A+ LE +IKE E EE
Sbjct: 340 RDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEE 399
Query: 477 LKR-------VKSEAIIAR---REPKEEAEDVSSYLCTESDKIPMAQRRRFTRVEMARVL 526
L R + E I + + ++A+++ + L E DK+ +++ +E
Sbjct: 400 LSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLE----- 454
Query: 527 MERNQYKERLMELQEAVRWTEMIRASREHPSVQEKKK 563
++K++L ++A + I+ + S++E KK
Sbjct: 455 ----EFKQKLCRAEQAFQ-ASQIKENELRRSMEEMKK 486
Score = 37.4 bits (85), Expect = 0.097
Identities = 25/122 (20%), Positives = 54/122 (44%)
Query: 49 EEVVKELMPLVVNVLENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKF 108
E+ ++ L ++ + L+ + S + E ELEL + D + + + A + + +
Sbjct: 2566 EQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREM 2625
Query: 109 IEFEDALEQEKKELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQRH 168
E + ++EL + + + L + K+ DQ+ L SE+KK + +H+
Sbjct: 2626 HEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQ 2685
Query: 169 TE 170
E
Sbjct: 2686 VE 2687
Score = 36.2 bits (82), Expect = 0.22
Identities = 110/586 (18%), Positives = 237/586 (40%), Gaps = 116/586 (19%)
Query: 60 VNVLENLDSVLSENQ--EHEVELELLREDNEQLLTQYEREKALRRQAEE----------K 107
+++L NL+ +S NQ EV L+E+N LT+ E A + EE
Sbjct: 1506 MSLLSNLEGAVSANQCSVDEVFCSSLQEEN---LTRKETPSAPAKGVEELESLCEVYRQS 1562
Query: 108 FIEFEDALEQE----KKELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYN- 162
+ E+ +E + KE+Q + + ++L+ K Y + + +++ + + E
Sbjct: 1563 LEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMES 1622
Query: 163 --ALHQRHTEMIQTYVEHIERSKMQQVGGNSQ------TESSLPGRRK------------ 202
A ++ TE + +E + R ++Q + +S+ TE ++ GR +
Sbjct: 1623 KLAAEKKQTEQLSLELE-VARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSET 1681
Query: 203 -ERPTSLNVFPLADGTVRAQIG---------GKLVPAGDHWHLSDLGQLQSSSSYQCPQD 252
ER +V + D + + G + P G+ G+ ++Y+ P +
Sbjct: 1682 TERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGEC-----SGEQSPDTNYEPPGE 1736
Query: 253 EMSESGQSSAAATPSTTGTKSNTPTS---------SVPSAAVTPLNESLQPLGDYGVGSK 303
+ ++ G S + S +G + P ++ NE+L+ L +
Sbjct: 1737 DKTQ-GSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVI----E 1791
Query: 304 NSKRAREKRDSRNMEVQVTQEMRNVSIGMGSSDEWSDVQDIIDSTPELDMCPETRLDRTG 363
+ R E + E+ ++ V + M + +++ I+ + + +L+
Sbjct: 1792 DRDRKVESLLNEMKELDSKLHLQEVQL-MTKIEACIELEKIVGELKKENSDLSEKLEYFS 1850
Query: 364 SSPTQGI--VNKAFGINTDSLYHELSTAGSEVIGDVDEGADLLGE-FSGMGKEVGNLLLE 420
+ + V + G+N+D H ++ ++ +V + D E F + E+ + E
Sbjct: 1851 CDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSE 1910
Query: 421 NSQL----LETKNALNVVKNDLIA-----------------KVDQLSGEQEVLRGELEAA 459
+ + L + L VV+ + + ++ ++ E+ LRGEL+
Sbjct: 1911 KASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTM 1970
Query: 460 KQ---AKVKLENRIKELEEELKRVKSEAI----IARREPKEEAE-------DVSSYLCTE 505
+ A +L ++KE +EL+ +SE + +A E KE+ E DVS L +
Sbjct: 1971 SKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDK 2030
Query: 506 S---DKIPM----AQRRRFTRVEMARVLMERNQYKERLMELQEAVR 544
+ +K+ +Q T+ E+ + + N+ KE L++ E+++
Sbjct: 2031 THLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQ 2076
Score = 36.2 bits (82), Expect = 0.22
Identities = 38/145 (26%), Positives = 65/145 (44%), Gaps = 18/145 (12%)
Query: 439 IAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELEEE-------LKRVKSEAIIARREP 491
I + QL E LR LEA ++ ++ + ++KE E ++ ++ E IAR
Sbjct: 2293 IEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQ 2352
Query: 492 KE---EAEDVSSYLCTESDKIP-MAQRRRFTRVEMARVLMERNQYKERLMELQEAVRWTE 547
+ EAE+ + T KI M Q R +++ + E+ L + QE + E
Sbjct: 2353 EHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELE 2412
Query: 548 MIRAS-------REHPSVQEKKKST 565
+I +S +E VQ K+KS+
Sbjct: 2413 IINSSFENILQEKEQEKVQMKEKSS 2437
Score = 35.4 bits (80), Expect = 0.37
Identities = 30/109 (27%), Positives = 51/109 (46%), Gaps = 13/109 (11%)
Query: 66 LDSVLSENQEHEVELELLREDNEQLLTQYEREKA----LRRQAEEKFIEFEDALEQEKK- 120
LD + E Q+ + +L+ L ++ + E EK L+R+ ++ +E ++LE+ K+
Sbjct: 27 LDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRE-NQRLMEICESLEKTKQK 85
Query: 121 ---ELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQ 166
ELQ++ FQ QL K QI +LE+ K E Q
Sbjct: 86 ISHELQVKESQVNFQEGQLNSGKK----QIEKLEQELKRCKSELERSQQ 130
Score = 33.9 bits (76), Expect = 1.1
Identities = 92/513 (17%), Positives = 197/513 (38%), Gaps = 72/513 (14%)
Query: 60 VNVLENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEK 119
+NV + L++ L E E + L +E+ QL E+ + E+K + + L++ +
Sbjct: 2087 LNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERE 2146
Query: 120 KELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHI 179
+E + E R+L++ +N I E ++E+ E ++T +E +
Sbjct: 2147 RENDSLKDKVENLERELQMSEENQELVILDAENSKAEV------------ETLKTQIEEM 2194
Query: 180 ERS----KMQQVGGNSQTES------SLPGRRKERPTSLNVF-PLADGTVRAQIGGKLVP 228
RS ++ V S+ E+ G+ E L+ F L + +A+I K
Sbjct: 2195 ARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIK--- 2251
Query: 229 AGDHWHLSDLGQLQSSSSYQCPQDEMSESGQSSAAATPSTTGTKSNTPTSSVPSAAVTPL 288
+S ++ + Q+++ E ++ AA K+ + P L
Sbjct: 2252 ------------EESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQL 2299
Query: 289 NESLQPLGDYGVGSKNSKRAREKRDSRN---MEVQVTQEMRNVSIGMGSSDEWSDVQDII 345
S++ L RAR + D + + Q+ + + + G + +I
Sbjct: 2300 RNSIEKL-----------RARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIA 2348
Query: 346 DSTPE---LDMCPETRLDRTGSSPTQGIVNKAFGINTDSLYHELSTAGSEVIGDVDEGAD 402
+ E L+ T + +G+ G+ D + + + + ++ + +
Sbjct: 2349 RTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVV--TIRSEKENLTNELQKEQE 2406
Query: 403 LLGEFSGMGKEVGNLLLENSQ-LLETKNALNVVKNDLIAKVDQLSGEQEVLRGELEAAKQ 461
+ E + N+L E Q ++ K + L ++ +L+ L + EA K
Sbjct: 2407 RISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKA 2466
Query: 462 AKVKLENRIKELEEE-------LKRVKSEAIIARREPK---EEAEDVSSYLCTESDKIP- 510
+ L ++++ LE E L K+ I+ + +E ED L + ++I
Sbjct: 2467 KEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISR 2526
Query: 511 ---MAQRRRFTRVEMARVLMERNQYKERLMELQ 540
Q + ++++V E +KE+ +EL+
Sbjct: 2527 LKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELR 2559
Score = 32.7 bits (73), Expect = 2.4
Identities = 34/168 (20%), Positives = 68/168 (40%), Gaps = 9/168 (5%)
Query: 36 IYREFERLIHCYDEEVVKELMPLVVNVLENLDSVLSENQEHEVELELLREDNEQLLTQYE 95
I R+F ++EV L + + +S +N L+ L+ N++L +
Sbjct: 237 IRRDFSASYFSGEQEVTPSRSTLQIGK-RDANSSFFDNSSSPHLLDQLKAQNQELRNKIN 295
Query: 96 REKALRRQAEEKFIEFEDALEQEKKELQIQVEHYEFQTRQLELKAKNYADQISRLEERES 155
E LR Q EK ++ + + +ELQ+Q+E + + + E D++ R +
Sbjct: 296 -ELELRLQGHEKEMKGQ---VNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYD 351
Query: 156 EMKKEYNALHQRHTEMIQTYVEHIERSKMQQVGGNSQTESSLPGRRKE 203
+ +Y AL Q+ ++ E + + E + + KE
Sbjct: 352 QASTKYTALEQK----LKKLTEDLSCQRQNAESARCSLEQKIKEKEKE 395
Score = 32.3 bits (72), Expect = 3.1
Identities = 51/225 (22%), Positives = 92/225 (40%), Gaps = 24/225 (10%)
Query: 64 ENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKELQ 123
E L++ L + EL+ + DN + + Q ++E + + I+ LE+EK+ LQ
Sbjct: 2754 EELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQ 2813
Query: 124 IQVEHYE-FQTRQ-----LELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVE 177
++ + Q +Q ++ K +I L+E E KE + ++ ++ ++ E
Sbjct: 2814 KELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISH-E 2872
Query: 178 HIERSKMQ---QVGGNSQTESSLPGRRKERPTSLNVFPLADGTVRAQIGGKLVPAGDHWH 234
+E++K QV +S R PL V G +P+
Sbjct: 2873 KLEKAKEMLETQVAHLCSQQSKQDSRGS---------PLLGPVVP---GPSPIPSVTEKR 2920
Query: 235 LSDLGQLQSSSSYQCPQDEMSESGQSSAAATPSTTGTKSNTPTSS 279
LS GQ ++S Q + E+G+ ATP + KS S
Sbjct: 2921 LSS-GQNKASGKRQ-RSSGIWENGRGPTPATPESFSKKSKKAVMS 2963
Score = 31.2 bits (69), Expect = 6.9
Identities = 49/212 (23%), Positives = 91/212 (42%), Gaps = 39/212 (18%)
Query: 136 LELKAKNYADQISRLEERESEMKKEYNALHQRHTEM------IQTYVEHIE------RSK 183
L L K + L+E+ ++ E+ LH +H +M +QTYV+ ++ +
Sbjct: 1393 LTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTN 1452
Query: 184 MQQVGGNSQTESSLPGRRKERPTSLNVFPLADGTVRAQIGGK------LVPAGDHWHLSD 237
++ G+ E L G + SL+ + D + + +G L GD LS+
Sbjct: 1453 LRNFQGDLVKEMQL-GLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSN 1511
Query: 238 LGQLQSSSSYQCPQDEMSESGQSSAAATPSTTGTKSNTPTSSVPSAAVTPLNESLQPLGD 297
L S++ QC DE+ ++ T+ TP S P+ V E L+ L +
Sbjct: 1512 LEGAVSAN--QCSVDEV------FCSSLQEENLTRKETP--SAPAKGV----EELESLCE 1557
Query: 298 YGVGSKNSKRAREKRDS----RNMEVQVTQEM 325
V ++ ++ EK +S +N E+Q +++
Sbjct: 1558 --VYRQSLEKLEEKMESQGIMKNKEIQELEQL 1587
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.130 0.380
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 56,878,580
Number of Sequences: 37866
Number of extensions: 3128179
Number of successful extensions: 24753
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 287
Number of HSP's successfully gapped in prelim test: 1076
Number of HSP's that attempted gapping in prelim test: 15791
Number of HSP's gapped (non-prelim): 8443
length of query: 1330
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1216
effective length of database: 13,930,794
effective search space: 16939845504
effective search space used: 16939845504
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.