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Search of human proteins with 93102364
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|93102364 SWAP-70 protein [Homo sapiens]
(585 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|93102364 SWAP-70 protein [Homo sapiens] 1167 0.0
gi|145312241 differentially expressed in FDCP 6 homolog [Homo sa... 510 e-144
gi|148746195 trichohyalin [Homo sapiens] 85 2e-16
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 84 3e-16
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 80 4e-15
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 80 4e-15
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 80 7e-15
gi|221139761 zinc finger protein 853 [Homo sapiens] 79 9e-15
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 79 9e-15
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 79 1e-14
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 79 2e-14
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 78 2e-14
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 77 3e-14
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 77 3e-14
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 77 3e-14
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 77 3e-14
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 77 3e-14
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 77 3e-14
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 77 3e-14
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 77 3e-14
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 77 3e-14
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap... 77 4e-14
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap... 77 4e-14
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap... 77 4e-14
gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi... 77 4e-14
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m... 76 7e-14
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m... 76 7e-14
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 75 2e-13
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 73 6e-13
gi|239745299 PREDICTED: hypothetical protein [Homo sapiens] 73 8e-13
>gi|93102364 SWAP-70 protein [Homo sapiens]
Length = 585
Score = 1167 bits (3019), Expect = 0.0
Identities = 585/585 (100%), Positives = 585/585 (100%)
Query: 1 MGSLKEELLKAIWHAFTALDQDHSGKVSKSQLKVLSHNLCTVLKVPHDPVALEEHFRDDD 60
MGSLKEELLKAIWHAFTALDQDHSGKVSKSQLKVLSHNLCTVLKVPHDPVALEEHFRDDD
Sbjct: 1 MGSLKEELLKAIWHAFTALDQDHSGKVSKSQLKVLSHNLCTVLKVPHDPVALEEHFRDDD 60
Query: 61 EGPVSNQGYMPYLNRFILEKVQDNFDKIEFNRMCWTLCVKKNLTKNPLLITEEDAFKIWV 120
EGPVSNQGYMPYLNRFILEKVQDNFDKIEFNRMCWTLCVKKNLTKNPLLITEEDAFKIWV
Sbjct: 61 EGPVSNQGYMPYLNRFILEKVQDNFDKIEFNRMCWTLCVKKNLTKNPLLITEEDAFKIWV 120
Query: 121 IFNFLSEDKYPLIIVSEEIEYLLKKLTEAMGGGWQQEQFEHYKINFDDSKNGLSAWELIE 180
IFNFLSEDKYPLIIVSEEIEYLLKKLTEAMGGGWQQEQFEHYKINFDDSKNGLSAWELIE
Sbjct: 121 IFNFLSEDKYPLIIVSEEIEYLLKKLTEAMGGGWQQEQFEHYKINFDDSKNGLSAWELIE 180
Query: 181 LIGNGQFSKGMDRQTVSMAINEVFNELILDVLKQGYMMKKGHRRKNWTERWFVLKPNIIS 240
LIGNGQFSKGMDRQTVSMAINEVFNELILDVLKQGYMMKKGHRRKNWTERWFVLKPNIIS
Sbjct: 181 LIGNGQFSKGMDRQTVSMAINEVFNELILDVLKQGYMMKKGHRRKNWTERWFVLKPNIIS 240
Query: 241 YYVSEDLKDKKGDILLDENCCVESLPDKDGKKCLFLVKCFDKTFEISASDKKKKQEWIQA 300
YYVSEDLKDKKGDILLDENCCVESLPDKDGKKCLFLVKCFDKTFEISASDKKKKQEWIQA
Sbjct: 241 YYVSEDLKDKKGDILLDENCCVESLPDKDGKKCLFLVKCFDKTFEISASDKKKKQEWIQA 300
Query: 301 IHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRK 360
IHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRK
Sbjct: 301 IHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRK 360
Query: 361 KLEEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVR 420
KLEEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVR
Sbjct: 361 KLEEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVR 420
Query: 421 ELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEA 480
ELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEA
Sbjct: 421 ELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEA 480
Query: 481 EKQELENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSWKDKVAH 540
EKQELENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSWKDKVAH
Sbjct: 481 EKQELENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSWKDKVAH 540
Query: 541 HEGLIRLIEPGSKNPHLITNWGPAAFTEAELEEREKNWKEKKTTE 585
HEGLIRLIEPGSKNPHLITNWGPAAFTEAELEEREKNWKEKKTTE
Sbjct: 541 HEGLIRLIEPGSKNPHLITNWGPAAFTEAELEEREKNWKEKKTTE 585
>gi|145312241 differentially expressed in FDCP 6 homolog [Homo
sapiens]
Length = 631
Score = 510 bits (1314), Expect = e-144
Identities = 268/588 (45%), Positives = 392/588 (66%), Gaps = 17/588 (2%)
Query: 3 SLKEELLKAIWHAFTALDQDHSGKVSKSQLKVLSHNLCTVLKVPHDPVALEEHFRDDDEG 62
+L++ELLK+IW+AFTALD + SGKVSKSQLKVLSHNL TVL +PHDPVALEEHFRDDD+G
Sbjct: 2 ALRKELLKSIWYAFTALDVEKSGKVSKSQLKVLSHNLYTVLHIPHDPVALEEHFRDDDDG 61
Query: 63 PVSNQGYMPYLNRFILEKVQDN-FDKIEFNRMCWTLCVKKNL---TKNPLLITEEDAFKI 118
PVS+QGYMPYLN++IL+KV++ F K F+ +CWTL KKN + +++ +DAF++
Sbjct: 62 PVSSQGYMPYLNKYILDKVEEGAFVKEHFDELCWTLTAKKNYRADSNGNSMLSNQDAFRL 121
Query: 119 WVIFNFLSEDKYPLIIVSEEIEYLLKKLTEAMG---GGWQQEQFEHYKINFDDSKNGLSA 175
W +FNFLSEDKYPLI+V +E+EYLLKK+ +M + E+ + + GLS
Sbjct: 122 WCLFNFLSEDKYPLIMVPDEVEYLLKKVLSSMSLEVSLGELEELLAQEAQVAQTTGGLSV 181
Query: 176 WELIELIGNGQFSKGMDRQTVSMAINEVFNELILDVLKQGYMMKKGHRRKNWTERWFVLK 235
W+ +EL +G+ +G+ R T+SMAI+EV+ ELI DVLKQGY+ K+GH R+NW ERWF L+
Sbjct: 182 WQFLELFNSGRCLRGVGRDTLSMAIHEVYQELIQDVLKQGYLWKRGHLRRNWAERWFQLQ 241
Query: 236 PNIISYYVSEDLKDKKGDILLDENCCVESLPDKDGKKCLFLVKCFDKTFEISASDKKKKQ 295
P+ + Y+ SE+ K+K+G I LD +CCVE LPD+DGK+C+F VK ++T+E+SASD +++Q
Sbjct: 242 PSCLCYFGSEECKEKRGIIPLDAHCCVEVLPDRDGKRCMFCVKTANRTYEMSASDTRQRQ 301
Query: 296 EWIQAIHSTIHLLKLGSPPPHKEARQRRKELR----KKQLAEQEELERQMKELQAANESK 351
EW AI I L G HK+ +Q+R+E R +++ A++EEL R +++LQ E K
Sbjct: 302 EWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLR-LQQLQEEKERK 360
Query: 352 QQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSE 411
QELE +++ +A EEE++R ELQ +L + R M+ ++ K E
Sbjct: 361 LQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEE 420
Query: 412 LEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQ 471
+ QR++ELE+M +LQEAL+ E +AR+DEE+VR Q RLLEEE K +L + EQ
Sbjct: 421 AARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQ 480
Query: 472 QQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVKKKLEMATNKT 531
++ I+ + EK+EL+ + + ++LQ+A +QLE++ R++A E E ++KL A+
Sbjct: 481 ERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNV 540
Query: 532 KSWKDKVAHHEGLIRLIEPGSKNPHLITNWGPAAFTEAELEEREKNWK 579
K W ++ L+ IEPG K P +T+ + F L R+ + K
Sbjct: 541 KHWNVQM---NRLMHPIEPGDKRP--VTSSSFSGFQPPLLAHRDSSLK 583
Score = 45.4 bits (106), Expect = 1e-04
Identities = 44/185 (23%), Positives = 75/185 (40%), Gaps = 18/185 (9%)
Query: 320 RQRRKELRKKQLAEQEELERQMK-------------ELQAANESKQQELEAVRKKLEEAA 366
RQR KEL + Q QE L+ ++K L E K ++L ++++ E
Sbjct: 425 RQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYI 484
Query: 367 SRAAEEEKKRLQTQVELQARF----STELEREKLIRQQMEEQVAQKSSELEQYLQRVREL 422
RA ++EK+ LQ ++ Q+R +LE + RQ+ +E V +L Q V+
Sbjct: 485 ERA-QQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHW 543
Query: 423 EDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEK 482
+L +E + + Q LL S L +W + + E+
Sbjct: 544 NVQMNRLMHPIEPGDKRPVTSSSFSGFQPPLLAHRDSSLKRLTRWGSQGNRTPSPNSNEQ 603
Query: 483 QELEN 487
Q+ N
Sbjct: 604 QKSLN 608
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 84.7 bits (208), Expect = 2e-16
Identities = 72/246 (29%), Positives = 129/246 (52%), Gaps = 17/246 (6%)
Query: 317 KEARQRRKELRKKQLAEQEELERQ-MKELQAANESKQQELEAVRKKLEEAASRAAEEEKK 375
+E +RR + R + E+E+LER+ KE + + Q+E + +R++ EE R + K
Sbjct: 1279 REQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKF 1338
Query: 376 RLQTQVELQARFSTELEREKLIRQQMEEQV-----AQKSSELEQYLQRVRELEDMYLKLQ 430
R + Q+ LQ R L R++ R+ EE++ +K E EQ L+R +E E +LK +
Sbjct: 1339 REEEQL-LQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRR-QERERKFLKEE 1396
Query: 431 EAL---EDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELEN 487
+ L E E+Q RQD + RK + EE+ R E ++ E++Q ++ E E++ LE
Sbjct: 1397 QQLRCQEREQQLRQDRD--RKFRE---EEQQLSRQERDRKFREEEQQVRRQERERKFLEE 1451
Query: 488 QRVLKEQALQEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSWKDKVAHHEGLIRL 547
++ L+++ ++ E+ + L+ +Q L + E +K LE + +D+ E +R
Sbjct: 1452 EQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDR-KFREQELRS 1510
Query: 548 IEPGSK 553
EP K
Sbjct: 1511 QEPERK 1516
Score = 82.8 bits (203), Expect = 8e-16
Identities = 55/237 (23%), Positives = 125/237 (52%), Gaps = 16/237 (6%)
Query: 317 KEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKL--------EEAASR 368
+E + +E RK+QL +E ER+ + L+ E ++++ E ++L E+ R
Sbjct: 462 EETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKR 521
Query: 369 AAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLK 428
EEE+ + + + E Q R E RE+L++++ E+++ Q+ E ++ + E D LK
Sbjct: 522 QEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERRE-QRLKREQEERRDQLLK 580
Query: 429 LQEALEDERQARQDEE----TVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQE 484
+E +R R+ EE +++ + LE+E + L++ E+++ Q ++E+QE
Sbjct: 581 REEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQE 640
Query: 485 LENQRVLKEQALQEAMEQLEQLELERK---QALEQYEEVKKKLEMATNKTKSWKDKV 538
Q+ L+ + + ++L++ E E + + ++EE +++ E+A + + ++++
Sbjct: 641 ERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERI 697
Score = 82.4 bits (202), Expect = 1e-15
Identities = 59/216 (27%), Positives = 117/216 (54%), Gaps = 11/216 (5%)
Query: 315 PHKEARQRRK--ELRKKQLAE--QEELERQMKELQAANESKQQELEAVRKKLEEAASRAA 370
P +E +RR+ ELR+K E Q+ ERQ + Q E + ++ E V +K EE
Sbjct: 205 PDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEE 264
Query: 371 EEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQ 430
+ ++ LQ + E Q R +LER++L R++ EE+ Q+ EQ L+R +E E + Q
Sbjct: 265 PQRQRELQEEEE-QLR---KLERQELRRERQEEEQQQQRLRREQQLRRKQEEE---RREQ 317
Query: 431 EALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRV 490
+ E+Q R++++ R+ Q E+E + +L + E+++ Q +++E Q++
Sbjct: 318 QEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQL 377
Query: 491 LKEQALQEAMEQLEQLELERKQALEQYEEVKKKLEM 526
+EQ L+ + + +L R+Q L + ++++++ ++
Sbjct: 378 RREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 413
Score = 80.1 bits (196), Expect = 5e-15
Identities = 75/258 (29%), Positives = 131/258 (50%), Gaps = 33/258 (12%)
Query: 290 DKKKKQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQEELERQMKELQAANE 349
+K+++QE + L + +E +RR++ R+K+ E+EEL+++ ++L
Sbjct: 949 EKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREER 1008
Query: 350 SKQQELEAVRK-------KLEEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQM- 401
K++ E R+ + EE E EK+RLQ + E Q R EL++E+ +Q+
Sbjct: 1009 EKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQER-ERQYREEEELQQEE---EQLL 1064
Query: 402 -EEQVAQKSSELEQYLQRVRELEDMYLKL-------QEALEDERQARQDEETVRKLQARL 453
EE+ ++ ELE+ ++ EL+ +L + E ERQ R++EE ++ + L
Sbjct: 1065 GEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLL 1124
Query: 454 LEE-ESSKRAELEKWHLEQQQAIQTTEA---------EKQELENQRVLKEQALQEAMEQL 503
EE E +R ELE+ + E+++ Q E +QELE Q +E+ LQ+ EQL
Sbjct: 1125 REEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQ-YREEEELQQEEEQL 1183
Query: 504 --EQLELERKQALEQYEE 519
E+ E R++ QY E
Sbjct: 1184 LREEQEKRRQERERQYRE 1201
Score = 79.7 bits (195), Expect = 7e-15
Identities = 59/261 (22%), Positives = 140/261 (53%), Gaps = 12/261 (4%)
Query: 281 DKTFEISASDKKKKQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQEELERQ 340
D+ F+ + +K+E + + L+ P +E ++ ++LRK E++EL R+
Sbjct: 235 DRVFQEEEEKEWRKRETV--LRKEEEKLQEEEPQRQRELQEEEEQLRK---LERQELRRE 289
Query: 341 MKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQ 400
+E + + ++E + +R+K EE EE +++ + + + + R +L RE+ R++
Sbjct: 290 RQEEEQQQQRLRRE-QQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERRE 348
Query: 401 MEEQVAQKSSELEQYLQRVRELE--DMYLKLQEALEDERQARQDEETVRKLQARLLEEES 458
+ + Q+ EQ L+R +E E + L+ ++ L E+Q R++++ R+ Q R E++
Sbjct: 349 QQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRR-EQQL 407
Query: 459 SKRAEL--EKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQALEQ 516
+ +L E+ +QQ + E E+ E ++++ +EQ L+ E+ L+R++ E+
Sbjct: 408 RREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDW-LKREEETER 466
Query: 517 YEEVKKKLEMATNKTKSWKDK 537
+E+ ++K ++ ++ + +++
Sbjct: 467 HEQERRKQQLKRDQEEERRER 487
Score = 78.2 bits (191), Expect = 2e-14
Identities = 68/284 (23%), Positives = 137/284 (48%), Gaps = 33/284 (11%)
Query: 290 DKKKKQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQEELERQMKEL--QAA 347
+K+++QEW + L + +E +RR + R++Q E+EEL+++ ++L +
Sbjct: 1009 EKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEER 1068
Query: 348 NESKQQELEAVRKKLEEAASRAA----EEEKKRLQTQVELQARFSTEL--EREKLIRQQM 401
++QELE +K EE EE +KR + + E Q R EL E E+L+R++
Sbjct: 1069 ETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREER 1128
Query: 402 EEQVAQKSSELEQYLQRVRELEDMYLKLQ----EALEDERQARQDEETVRKLQARLLEEE 457
E++ Q+ + + V++ E+ L+ + E ERQ R++EE ++ + L EE+
Sbjct: 1129 EKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQ 1188
Query: 458 SSKRAELEKWHLEQQQAIQTTEAEKQELENQR--------VLKEQALQ-----------E 498
+R E E+ + E+++ + ++ E+QR KE A++ E
Sbjct: 1189 EKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENE 1248
Query: 499 AMEQLEQLELERKQALEQYEEV--KKKLEMATNKTKSWKDKVAH 540
QLE +L +Q+ + + + +++ + + W+ + H
Sbjct: 1249 QFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRH 1292
Score = 77.0 bits (188), Expect = 4e-14
Identities = 62/247 (25%), Positives = 130/247 (52%), Gaps = 20/247 (8%)
Query: 317 KEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKR 376
++ R+ ++E R++QL ++E ER+ ++L+ E +++E + R++ + E++ R
Sbjct: 337 QQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLR 396
Query: 377 LQTQV--------ELQARFSTELEREK-LIRQQMEEQVAQKSSE--LEQYLQRVRELEDM 425
+ Q+ E Q R +L RE+ L R+Q EE+ QK + EQ L+R +E
Sbjct: 397 REQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRD 456
Query: 426 YLKLQEALEDERQARQDEETVR----KLQARLLEEESSKRAELEKWHLEQQQAIQTTEAE 481
+LK +E E Q R+ ++ R + + R L+ E +R E ++ ++Q ++ + E
Sbjct: 457 WLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQE---RREQQLRREQEE 513
Query: 482 KQELENQRVLKEQALQEAMEQLEQLELERKQALEQY--EEVKKKLEMATNKTKSWKDKVA 539
++E +R +E+ LQ+ + +QL E+++ EQ E +K+LE + + +++
Sbjct: 514 RREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEE 573
Query: 540 HHEGLIR 546
+ L++
Sbjct: 574 RRDQLLK 580
Score = 76.6 bits (187), Expect = 6e-14
Identities = 61/233 (26%), Positives = 115/233 (49%), Gaps = 15/233 (6%)
Query: 317 KEARQRRKELRKKQLAEQEELERQMKELQAANES--KQQELEAVRKKLEEAASRAAEEEK 374
KE R+R LRK++ QEE ++ +ELQ E K + E R++ EE E+++
Sbjct: 244 KEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEE------EQQQ 297
Query: 375 KRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRE--LEDMYLKLQEA 432
+RL+ + +L+ + E ++ R++ +E+ Q+ EQ L+R +E E + QE
Sbjct: 298 QRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEE 357
Query: 433 LEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLK 492
E+Q R+++E R+ Q L E R E + +Q + Q E+Q Q++ +
Sbjct: 358 ERREQQLRREQEEERREQQ--LRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRR 415
Query: 493 EQALQEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSW---KDKVAHHE 542
EQ L+ + + E ER + + E +++L+ + + W +++ HE
Sbjct: 416 EQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHE 468
Score = 76.3 bits (186), Expect = 7e-14
Identities = 56/237 (23%), Positives = 117/237 (49%), Gaps = 11/237 (4%)
Query: 315 PHKEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEK 374
P + RQ+R+E ++ +E+ E+Q + Q + + +EL R++ +E R AEEE+
Sbjct: 133 PGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQ 192
Query: 375 ---------KRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDM 425
+ + +L+ R EL R+ +Q + + Q E+ + R+ E +
Sbjct: 193 LQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETV 252
Query: 426 YLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQEL 485
K +E L++E RQ E + Q R LE + +R E+ +QQQ ++ + +++
Sbjct: 253 LRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEE--EQQQQRLRREQQLRRKQ 310
Query: 486 ENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSWKDKVAHHE 542
E +R +++ +E E+ EQ E R+Q L + +E +++ ++ + + +++ E
Sbjct: 311 EEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRRE 367
Score = 75.1 bits (183), Expect = 2e-13
Identities = 64/245 (26%), Positives = 121/245 (49%), Gaps = 16/245 (6%)
Query: 317 KEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKR 376
+E + RR+E +K E+++L RQ +E + E +Q + + +K E E E
Sbjct: 1680 EEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETE--- 1736
Query: 377 LQTQVELQARFSTELEREKLIRQQMEEQVA--QKSSELEQYLQRVRELEDMYLKLQEA-- 432
Q Q+ Q R+ LE E+L ++ E+Q+ ++ + + Q +E E+ L+ QE+
Sbjct: 1737 -QEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDR 1795
Query: 433 -LEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQ-ELENQRV 490
+E Q RQ+ E + Q R + + R E E+ LE+Q+ E ++Q E Q
Sbjct: 1796 KFREEEQLRQERE---EQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFA 1852
Query: 491 LKEQALQEAMEQLEQLELERKQALE---QYEEVKKKLEMATNKTKSWKDKVAHHEGLIRL 547
+E++ +E E ++ E +R+Q E + E ++++ + + + K +G RL
Sbjct: 1853 TQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGHGRL 1912
Query: 548 IEPGS 552
+EPG+
Sbjct: 1913 LEPGT 1917
Score = 74.7 bits (182), Expect = 2e-13
Identities = 62/239 (25%), Positives = 125/239 (52%), Gaps = 11/239 (4%)
Query: 294 KQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQEELERQMKELQAANESKQQ 353
K +W + K+ S P +E ++RR+E +K+ + EL Q +E + A+ +Q+
Sbjct: 703 KWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESEL--QWQEEERAHRQQQE 760
Query: 354 ELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELE 413
E + + A +E ++RL + L+ + +L E+ RQQ E++ + E E
Sbjct: 761 EEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEE--RQQREQRFLPEEEEKE 818
Query: 414 Q--YLQRVRELEDMYLKLQEALEDERQARQ---DEETVRKLQARLLEEESSKRAELEKWH 468
Q +R RE E +L+ +E L+ +A+Q +E+ +++ Q R +E +R + +W
Sbjct: 819 QRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQE-QRRDQKWRWQ 877
Query: 469 LEQQQAIQT-TEAEKQELENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVKKKLEM 526
LE+++ + T K L+ Q ++Q LQE E+L++ E E+++ EQ + +++ ++
Sbjct: 878 LEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQL 936
Score = 74.7 bits (182), Expect = 2e-13
Identities = 72/219 (32%), Positives = 114/219 (52%), Gaps = 21/219 (9%)
Query: 316 HKEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKK 375
++E Q ++E + E+E+ RQ +E Q + K Q+ E + EE R +E +K
Sbjct: 930 YREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEE-QLLGEEPEKRRRQEREK 988
Query: 376 RLQTQVELQARFSTEL--EREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEAL 433
+ + + ELQ L EREK RQ+ E Q +K EL+Q +++ E +LQE
Sbjct: 989 KYREEEELQQEEEQLLREEREKRRRQEWERQY-RKKDELQQEEEQLLREEREKRRLQER- 1046
Query: 434 EDERQARQDEETVRKLQARLLEE-ESSKRAELEKWHLEQQQAIQTTE---------AEKQ 483
ERQ R++EE ++ + L EE E+ +R ELE+ + ++++ Q E +Q
Sbjct: 1047 --ERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQ 1104
Query: 484 ELENQRVLKEQALQEAMEQL--EQLELERKQALE-QYEE 519
E E Q +E+ LQ+ EQL E+ E R+Q LE QY E
Sbjct: 1105 ERERQ-CREEEELQQEEEQLLREEREKRRRQELERQYRE 1142
Score = 74.3 bits (181), Expect = 3e-13
Identities = 56/238 (23%), Positives = 120/238 (50%), Gaps = 9/238 (3%)
Query: 317 KEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKR 376
+E ++ R+E ++++ ++E E+Q++ Q +Q E ++ E+ R EEE++
Sbjct: 315 REQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERRE 374
Query: 377 LQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVREL-EDMYLKLQEALED 435
Q + E Q R +L RE+ +R++ + + Q+ EQ L+R ++L + L+ ++ E
Sbjct: 375 QQLRREQQLRREQQLRREQQLRREQQLRREQQLRR-EQQLRREQQLRREQQLRREQEEER 433
Query: 436 ERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLK--E 493
Q + E ++L+ E + E E EQ++ Q + +++E +R LK E
Sbjct: 434 HEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEE 493
Query: 494 QALQEAMEQLEQ-----LELERKQALEQYEEVKKKLEMATNKTKSWKDKVAHHEGLIR 546
+ +E E+ EQ E R+Q L++ EE ++ + ++ + +++ E L++
Sbjct: 494 EERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLK 551
Score = 74.3 bits (181), Expect = 3e-13
Identities = 68/239 (28%), Positives = 124/239 (51%), Gaps = 23/239 (9%)
Query: 317 KEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKR 376
+E +RR L++++ E+ E ER+ ++L+ E +++E KLEE EE++
Sbjct: 449 REQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWL---KLEE-------EERRE 498
Query: 377 LQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVR-ELEDMYLKLQE--AL 433
Q + E Q R E RE+ +++Q EE+ Q+ EQ L+R + E + LK +E L
Sbjct: 499 QQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRL 558
Query: 434 EDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQ--QQAIQTTEAEKQELE---NQ 488
E ER+ ++ + + + +LL+ E +R + K E+ +Q ++ E E+ E E Q
Sbjct: 559 EQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQ 618
Query: 489 RVLKEQALQEAMEQL---EQLELERKQAL--EQYEEVKKKLEMATNKTKSWKDKVAHHE 542
R+ +E+ +E +QL E+ E R+Q L EQ E +++L+ + + + HE
Sbjct: 619 RLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHE 677
Score = 72.4 bits (176), Expect = 1e-12
Identities = 65/219 (29%), Positives = 118/219 (53%), Gaps = 30/219 (13%)
Query: 317 KEARQRRKELRKKQLAEQEELERQMKE--------LQAANESKQQELEAVRKKLEEAASR 368
++ R+ ++E R +Q EQE E+++K L+ E+++ E E +++L+ R
Sbjct: 423 QQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLK----R 478
Query: 369 AAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLK 428
EEE++ ++E + R + RE+ +R++ EE+ EQ L+R E E +
Sbjct: 479 DQEEERRERWLKLEEEERREQQERREQQLRREQEER-------REQRLKRQEEEE----R 527
Query: 429 LQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQ 488
LQ+ L E+Q R+++E R+ +LL+ E KR E E+ EQ+ + E Q L+ +
Sbjct: 528 LQQRLRSEQQLRREQEERRE---QLLKREEEKRLEQER--REQRLKREQEERRDQLLKRE 582
Query: 489 RVLKEQAL-QEAMEQLEQ-LELERKQALEQYEEVKKKLE 525
++Q L +E E+LEQ L+ E + LEQ E +++L+
Sbjct: 583 EERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLK 621
Score = 72.4 bits (176), Expect = 1e-12
Identities = 63/227 (27%), Positives = 111/227 (48%), Gaps = 18/227 (7%)
Query: 317 KEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKR 376
+E R+RR+ + A QE+L ++ + LQ E Q+E R++ E+ EE+ ++
Sbjct: 879 EEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQ 938
Query: 377 LQTQVELQARFSTEL-EREKLIR-----QQMEEQVAQKSSELEQYLQR---VRELEDMYL 427
+ Q+ + R ERE+ R QQ EEQ+ + E + +R RE E++
Sbjct: 939 EEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQ 998
Query: 428 KLQEALEDERQARQDEE---TVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQE 484
+ ++ L +ER+ R+ +E RK EEE R E EK L++++ E E Q+
Sbjct: 999 EEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQ 1058
Query: 485 LENQRVLKE------QALQEAMEQLEQLELERKQALEQYEEVKKKLE 525
E Q + +E Q L+ + E+L+ E +Q L + E +++ E
Sbjct: 1059 EEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQE 1105
Score = 72.4 bits (176), Expect = 1e-12
Identities = 66/233 (28%), Positives = 119/233 (51%), Gaps = 35/233 (15%)
Query: 317 KEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVR-----KKL--------- 362
+E +RR++ +++Q E+E+L+++ ++L K++ E R KKL
Sbjct: 916 EEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLG 975
Query: 363 EEAASRAAEEEKKRLQTQVELQARFSTEL--EREKLIRQQMEEQVAQKSSELEQYLQRVR 420
EE R +E +K+ + + ELQ L EREK RQ+ E Q +K EL+Q +++
Sbjct: 976 EEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQY-RKKDELQQEEEQLL 1034
Query: 421 ELEDMYLKLQEALEDERQARQDEETVRKLQARLLEE-ESSKRAELEKWHLEQQQAIQTTE 479
E +LQE ERQ R++EE ++ + L EE E+ +R ELE+ + +++
Sbjct: 1035 REEREKRRLQER---ERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEE------- 1084
Query: 480 AEKQELENQRVLKE------QALQEAMEQLEQLELERKQALEQYEEVKKKLEM 526
E Q+ E Q + +E Q + + E+L+ E +Q L + E +++ E+
Sbjct: 1085 -ELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQEL 1136
Score = 71.6 bits (174), Expect = 2e-12
Identities = 53/220 (24%), Positives = 124/220 (56%), Gaps = 18/220 (8%)
Query: 320 RQRRK-ELRKKQLAEQEELE----RQMKELQAANESKQQEL-EAVRKKLEEAASRAAEEE 373
RQR++ + R+++ AE+E+L+ + +E + +++EL E RK EE + E +
Sbjct: 175 RQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQ 234
Query: 374 KKRLQTQVELQARFSTELEREKLIR---QQMEEQVAQKSSELEQYLQRVRELEDMYLKLQ 430
+ Q + E + R +RE ++R ++++E+ Q+ EL++ +++R+LE L+ +
Sbjct: 235 DRVFQEEEEKEWR-----KRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRE 289
Query: 431 EALEDERQ--ARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQ 488
E+++Q R++++ RK + E++ +R + E+ ++++ Q E++E Q
Sbjct: 290 RQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQ 349
Query: 489 RVLKEQALQEAMEQL--EQLELERKQALEQYEEVKKKLEM 526
++ +EQ + +QL EQ E R+Q L + ++++++ ++
Sbjct: 350 QLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQL 389
Score = 71.6 bits (174), Expect = 2e-12
Identities = 61/212 (28%), Positives = 116/212 (54%), Gaps = 17/212 (8%)
Query: 321 QRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQ 380
+R ++LR++Q +E+ R+ ++L+ E ++ E + +++ E+ R EE + L+ +
Sbjct: 402 RREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKRE 461
Query: 381 VELQARFSTELEREKLIRQQMEEQVAQ--KSSELEQYLQRVRELEDMYLKLQEALEDERQ 438
E + R E +++L R Q EE+ + K E E+ Q+ R E + QE ++R
Sbjct: 462 EETE-RHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERR-EQQLRREQEERREQRL 519
Query: 439 ARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEK--QELENQRVLKEQAL 496
RQ+EE +LQ RL E+ +R + E+ ++Q ++ E ++ QE QR+ +EQ
Sbjct: 520 KRQEEE--ERLQQRLRSEQQLRREQEER----REQLLKREEEKRLEQERREQRLKREQ-- 571
Query: 497 QEAMEQLEQLELERKQ---ALEQYEEVKKKLE 525
+E +QL + E ER+Q EQ E ++++L+
Sbjct: 572 EERRDQLLKREEERRQQRLKREQEERLEQRLK 603
Score = 71.6 bits (174), Expect = 2e-12
Identities = 57/224 (25%), Positives = 116/224 (51%), Gaps = 13/224 (5%)
Query: 317 KEARQRRKELRKKQLAEQEE-----LERQMKELQAANESKQQELEAVRKKLEEAASRAAE 371
+E R+R +L +++ EQ+E L R+ +E + +Q+E E ++++L E
Sbjct: 482 EERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRRE 541
Query: 372 EEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQ--KSSELEQYLQRVRELEDMYLKL 429
+E++R Q + + + RE+ ++++ EE+ Q K E + + RE E+ +L
Sbjct: 542 QEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEE---RL 598
Query: 430 QEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQR 489
++ L+ E R ++E R+ + + E E +R +L K ++++ Q E+QE QR
Sbjct: 599 EQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQR 658
Query: 490 VLKEQALQEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKS 533
LK + +E +EQ +L+ E ++ + E +++ E A + KS
Sbjct: 659 -LKREEEEERLEQ--RLKREHEEERREQELAEEEQEQARERIKS 699
Score = 71.2 bits (173), Expect = 2e-12
Identities = 54/223 (24%), Positives = 115/223 (51%), Gaps = 18/223 (8%)
Query: 314 PPHKEARQRRKELRKKQ-----LAEQEELERQMK--ELQAANESKQQELEAVRKKLEEAA 366
P +E QRR++ R+++ L E+E+L+R+ + +LQ + Q++ E R + +
Sbjct: 812 PEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRD 871
Query: 367 SR---AAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELE 423
+ EEE+KR + + + +L +E+ + Q+ EE++ ++ E+ +R +E E
Sbjct: 872 QKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQRE----EREKRRRQEQE 927
Query: 424 DMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQ 483
Y + ++ ++E Q ++E R+ Q E E R + + E+Q + E ++
Sbjct: 928 RQYREEEQLQQEEEQLLREEREKRRRQ----ERERQYRKDKKLQQKEEQLLGEEPEKRRR 983
Query: 484 ELENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVKKKLEM 526
+ ++ +E+ LQ+ EQL + E E+++ E + +KK E+
Sbjct: 984 QEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDEL 1026
Score = 70.9 bits (172), Expect = 3e-12
Identities = 67/245 (27%), Positives = 123/245 (50%), Gaps = 17/245 (6%)
Query: 290 DKKKKQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQEELERQMKELQAANE 349
++K+++ + A + L+ +E + ++E R+K+ ++E ERQ +E + +
Sbjct: 881 ERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKR--RRQEQERQYREEEQLQQ 938
Query: 350 SKQQELEAVR-KKLEEAASRAAEEEKKRLQTQVEL---QARFSTELEREKLIRQQMEEQV 405
++Q L R K+ + R ++KK Q + +L + EREK R+ EE++
Sbjct: 939 EEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYRE--EEEL 996
Query: 406 AQKSSEL---EQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRA 462
Q+ +L E+ +R +E E Y K E ++E Q ++E R+LQ E E R
Sbjct: 997 QQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQ----ERERQYRE 1052
Query: 463 ELEKWHLEQQQAIQTTEA-EKQELENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVK 521
E E E+Q + E +QELE Q KE+ LQ+ EQL + E E+++ E+ + +
Sbjct: 1053 EEELQQEEEQLLGEERETRRRQELERQ-YRKEEELQQEEEQLLREEPEKRRRQERERQCR 1111
Query: 522 KKLEM 526
++ E+
Sbjct: 1112 EEEEL 1116
Score = 70.5 bits (171), Expect = 4e-12
Identities = 66/233 (28%), Positives = 117/233 (50%), Gaps = 29/233 (12%)
Query: 315 PHKEARQR--RKELRKKQLAEQEEL-----ERQMKELQAANESKQQELEAVRKKLEEAAS 367
P +E +R +KE +++ QEE ER+ K + + K +E E + ++ EE
Sbjct: 1294 PEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPL 1353
Query: 368 RAAEEEKKRLQTQVELQARFSTELEREKLIRQQ------MEEQVAQKSSELEQYLQRVRE 421
R E ++K + ++ Q + LE E+ +R+Q ++E+ + E EQ L++ R+
Sbjct: 1354 RRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRD 1413
Query: 422 L----EDMYLKLQEALEDERQARQDEETVRK--LQARLLEEESSKRAELEKWHLEQQQAI 475
E+ L QE +R+ R++E+ VR+ + + LEEE R E + E++Q +
Sbjct: 1414 RKFREEEQQLSRQER---DRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLL 1470
Query: 476 QTTEAEKQELENQRVLKEQALQEAMEQLEQLELERK---QALEQYEEVKKKLE 525
Q E E+Q+L Q +++ E +QL + E +RK Q L E +K LE
Sbjct: 1471 Q--EREEQQLHRQE--RDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLE 1519
Score = 69.3 bits (168), Expect = 9e-12
Identities = 59/221 (26%), Positives = 113/221 (51%), Gaps = 17/221 (7%)
Query: 318 EARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEA--ASRAAEEEKK 375
+ R+R ++L++++ QE+ ER+ + Q ++ + +LE RK+ A A +E+ +
Sbjct: 841 QRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLR 900
Query: 376 RLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALED 435
+ Q ++ + EREK RQ+ E Q ++ ++ Q +RE + + E
Sbjct: 901 KEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREK----RRRQER 956
Query: 436 ERQARQDEETVRKLQARLLEE-ESSKRAELEKWHLEQQQAIQTTE---------AEKQEL 485
ERQ R+D++ +K + L EE E +R E EK + E+++ Q E +QE
Sbjct: 957 ERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEW 1016
Query: 486 ENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVKKKLEM 526
E Q K+ LQ+ EQL + E E+++ E+ + +++ E+
Sbjct: 1017 ERQ-YRKKDELQQEEEQLLREEREKRRLQERERQYREEEEL 1056
Score = 69.3 bits (168), Expect = 9e-12
Identities = 66/278 (23%), Positives = 137/278 (49%), Gaps = 27/278 (9%)
Query: 317 KEARQRRKELRKKQLAEQEELERQM-----KELQAANESKQQEL---EAVRKKLEEAAS- 367
+E + RR+E +K L E+++L ++ +E Q E ++Q+L E RK LEE
Sbjct: 1435 EEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQL 1494
Query: 368 RAAEEEKKRLQTQVELQARFSTELEREK-LIRQQMEEQVAQKSSEL--EQYLQRVRELED 424
R E ++K + ++ Q LE E+ L RQQ + + Q+ +L ++ Q+ R+ D
Sbjct: 1495 RRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRD 1554
Query: 425 MYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQE 484
+ +E L ER+ +Q R + R LEE+ +R E E+ +E +Q ++ E + Q+
Sbjct: 1555 RKFREEEQLRQEREEQQLSRQERDRKFR-LEEQKVRRQEQERKFMEDEQQLRRQEGQ-QQ 1612
Query: 485 LENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSWKDKVAHHEGL 544
L +R K + ++ +++ E+ +L R++ ++ E + +L + + D+
Sbjct: 1613 LRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREE 1672
Query: 545 IRLIEPGSKNPHLITNWGPAAFTEAELEEREKNWKEKK 582
+L++ G + + +ER++ ++E++
Sbjct: 1673 EQLLQEGEEQ-------------QLRRQERDRKFREEE 1697
Score = 68.9 bits (167), Expect = 1e-11
Identities = 51/234 (21%), Positives = 119/234 (50%), Gaps = 8/234 (3%)
Query: 317 KEARQRRKELRKKQLAEQEELER--QMKELQAANESKQQELEAVRKKLEEAASRAAEEEK 374
+E +Q+++ R++QL ++E ER Q +E + E ++Q+ E ++L E++
Sbjct: 292 EEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQL 351
Query: 375 KRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSEL--EQYLQRVREL-EDMYLKLQE 431
+R Q + + + E E E+ +Q EQ ++ +L EQ L+R ++L + L+ ++
Sbjct: 352 RREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQ 411
Query: 432 ALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVL 491
L E+Q R++++ R+ + E++ + ++ EQ++ + E++ +++
Sbjct: 412 QLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQER 471
Query: 492 KEQALQEAMEQLEQ---LELERKQALEQYEEVKKKLEMATNKTKSWKDKVAHHE 542
++Q L+ E+ + L+LE ++ EQ E +++L + + + K E
Sbjct: 472 RKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEE 525
Score = 68.6 bits (166), Expect = 2e-11
Identities = 69/285 (24%), Positives = 132/285 (46%), Gaps = 24/285 (8%)
Query: 309 KLGSPPPHKEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASR 368
+L + PP +E R+R+ ++Q EQ L + ++ Q + +++E E + LEE
Sbjct: 783 RLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKEL--QFLEEEEQL 840
Query: 369 AAEEEKKRLQT-----QVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELE 423
E ++LQ Q + + R S E R++ R Q+EE+ ++ L +L
Sbjct: 841 QRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLR 900
Query: 424 DMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQ 483
LQE E+E Q + E+ R+ Q R EE + E E+ E+++ + E E+Q
Sbjct: 901 KEQQLLQEE-EEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQ 959
Query: 484 ELENQRVLK--EQALQEAMEQLEQLELERK----QALEQYEEVKKKLEMATNKTKSWKDK 537
+++++ + EQ L E E+ + E E+K + L+Q EE + E + + W+ +
Sbjct: 960 YRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQ 1019
Query: 538 VAHHEGLIRLIEPGSKNPHLITNWGPAAFTEAELEEREKNWKEKK 582
+ L + E + + L+ERE+ ++E++
Sbjct: 1020 YRKKDELQQEEEQLLREER----------EKRRLQERERQYREEE 1054
Score = 68.2 bits (165), Expect = 2e-11
Identities = 69/267 (25%), Positives = 120/267 (44%), Gaps = 28/267 (10%)
Query: 290 DKKKKQEWIQAIHSTIHLLKLGSPPP----HKEARQRRKELR-----KKQLAEQEELERQ 340
+K+++QE + LL+ P ++ + R +ELR +K L E++ L RQ
Sbjct: 1327 EKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQ 1386
Query: 341 MKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTE------LERE 394
+E + E +Q + ++L + R EE+++L Q E +F E ERE
Sbjct: 1387 ERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQ-ERDRKFREEEQQVRRQERE 1445
Query: 395 KLI---RQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEA----LEDERQARQDEETVR 447
+ QQ+ ++ +K E EQ LQ E E+ L QE LE+E+Q R+ E +
Sbjct: 1446 RKFLEEEQQLRQERHRKFREEEQLLQ---EREEQQLHRQERDRKFLEEEQQLRRQERDRK 1502
Query: 448 KLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQR--VLKEQALQEAMEQLEQ 505
+ L +E ++ E+ L +QQ + E+Q+L Q + Q + EQ
Sbjct: 1503 FREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQ 1562
Query: 506 LELERKQALEQYEEVKKKLEMATNKTK 532
L ER++ +E +K + K +
Sbjct: 1563 LRQEREEQQLSRQERDRKFRLEEQKVR 1589
Score = 67.8 bits (164), Expect = 3e-11
Identities = 62/242 (25%), Positives = 110/242 (45%), Gaps = 20/242 (8%)
Query: 317 KEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKR 376
+E +R ++ R++Q ++E+ ER+ + L+ E +QQ L+ R++ E R EE +R
Sbjct: 552 REEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLK--REQEERLEQRLKREEVER 609
Query: 377 LQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDE 436
L+ + + R E E E+ RQQ+ + Q+ +Q + +E + LK +E E
Sbjct: 610 LEQEERREQRLKRE-EPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERL 668
Query: 437 RQARQDEETVRKLQARLLEEESSKRAELEK-------WHLEQQ----QAIQTTEAEKQEL 485
Q + E + + L EEE + E K W LE + Q+ + KQE
Sbjct: 669 EQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEG 728
Query: 486 ENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSWKDKVAHHEGLI 545
+ +R +E+ + +L+ E ER +Q EE ++ T W+ + G
Sbjct: 729 QRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDF------TWQWQAEEKSERGRQ 782
Query: 546 RL 547
RL
Sbjct: 783 RL 784
Score = 67.8 bits (164), Expect = 3e-11
Identities = 59/212 (27%), Positives = 116/212 (54%), Gaps = 29/212 (13%)
Query: 317 KEARQRRKELRKKQLAEQEELERQ--MKELQAANESKQQELEAVRKKLEEAASRAAEEEK 374
+E + RR+E +K + ++++L RQ ++L+ + K +E E + ++ EE E ++
Sbjct: 1584 EEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDR 1643
Query: 375 KRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALE 434
K L+ + +L+ + ERE+ +R + +K E EQ LQ E E+ L+ QE
Sbjct: 1644 KFLEEEPQLRRQ-----EREQQLRHDRD----RKFREEEQLLQ---EGEEQQLRRQER-- 1689
Query: 435 DERQARQDEETVRKLQAR---LLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVL 491
+R+ R++E+ +R+ + L EE+ +R ELE+ E++Q +QE E +++
Sbjct: 1690 -DRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQL-------RQETEQEQLR 1741
Query: 492 KEQALQEAMEQLEQLELER-KQALEQYEEVKK 522
+++ ++ +E+ EQL ER +Q L + E +K
Sbjct: 1742 RQERYRKILEE-EQLRPEREEQQLRRQERDRK 1772
Score = 65.5 bits (158), Expect = 1e-10
Identities = 50/217 (23%), Positives = 112/217 (51%), Gaps = 13/217 (5%)
Query: 317 KEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKR 376
+E R +E +K L E+++L RQ ++ + E +Q ++ E R + ++K
Sbjct: 1504 REQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQL------RRQERGQQRRQDRDRKF 1557
Query: 377 LQTQVELQARFSTELEREKLIRQ-QMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALED 435
+ + Q R +L R++ R+ ++EEQ ++ + ++++ ++L + Q E
Sbjct: 1558 REEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQER 1617
Query: 436 ERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQA 495
+R+ R+DE+ LQ R EE+ R E ++ LE++ ++ E E Q+L + R K +
Sbjct: 1618 DRKFREDEQL---LQER--EEQQLHRQERDRKFLEEEPQLRRQERE-QQLRHDRDRKFRE 1671
Query: 496 LQEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTK 532
++ +++ E+ +L R++ ++ E +++L + K
Sbjct: 1672 EEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERK 1708
Score = 65.1 bits (157), Expect = 2e-10
Identities = 60/246 (24%), Positives = 124/246 (50%), Gaps = 22/246 (8%)
Query: 317 KEARQRRKELRKKQLAE----QEELERQMKELQAANESKQQEL---EAVRKKLEEAAS-R 368
+E ++RR+E +K E QE E+ ++ + + +++EL E RK LEE R
Sbjct: 1325 REEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLR 1384
Query: 369 AAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELE-QYLQRVRELEDMYL 427
E E+K L+ + +L+ + ERE+ +RQ + + ++ +L Q R E+ +
Sbjct: 1385 RQERERKFLKEEQQLRCQ-----EREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQV 1439
Query: 428 KLQEA----LEDERQARQDEETVRKLQARLL---EEESSKRAELEKWHLEQQQAIQTTEA 480
+ QE LE+E+Q RQ+ + + +LL EE+ R E ++ LE++Q ++ E
Sbjct: 1440 RRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQER 1499
Query: 481 EKQELENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSWKDKVAH 540
++ + Q + ++ ++ +E+ +QL +++Q EE + + + + + +D+
Sbjct: 1500 DR-KFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFR 1558
Query: 541 HEGLIR 546
E +R
Sbjct: 1559 EEEQLR 1564
Score = 65.1 bits (157), Expect = 2e-10
Identities = 47/224 (20%), Positives = 117/224 (52%), Gaps = 21/224 (9%)
Query: 317 KEARQRRKELRKKQLAEQEELERQMKELQAANESKQQ----ELEAVRKKLEEAASRAAEE 372
+E Q+R++ R ++ E+E+L ++ +E Q + + + + E + VR++ +E E+
Sbjct: 1543 QERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQ 1602
Query: 373 EKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEA 432
+ +R + Q +L+ + ++ + Q+ EEQ + ++L+ +L + Q
Sbjct: 1603 QLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLR 1662
Query: 433 LEDERQARQDEETVRKLQARLL-----------EEESSKRAELEKWHLEQQQAIQTTEAE 481
+ +R+ R++E+ +++ + + L EE+ +R E E+ L+++Q ++
Sbjct: 1663 HDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLR----- 1717
Query: 482 KQELENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVKKKLE 525
+QELE ++ +E+ L++ EQ + ER + + + E+++ + E
Sbjct: 1718 RQELE-RKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPERE 1760
Score = 64.3 bits (155), Expect = 3e-10
Identities = 59/233 (25%), Positives = 117/233 (50%), Gaps = 15/233 (6%)
Query: 323 RKELRKKQLAEQEELERQ-MKELQ-AANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQ 380
R+ + +QL + + +RQ ++LQ E ++++ E R++ ++ EEE+ + Q
Sbjct: 1245 RENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQ 1304
Query: 381 VELQARFSTELEREKLIRQQMEE-----QVAQKSSELEQYLQRVRELEDMYLKLQEALED 435
E + R E ++L+R++ EE + +K E EQ LQ E E+ L+ QE
Sbjct: 1305 KEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQ---EREEQPLRRQER--- 1358
Query: 436 ERQARQDEETVRKLQARLLEEESS-KRAELEKWHLEQQQAIQTTEAEKQ-ELENQRVLKE 493
+R+ R++E ++ + LEEE +R E E+ L+++Q ++ E E+Q + R +E
Sbjct: 1359 DRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFRE 1418
Query: 494 QALQEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSWKDKVAHHEGLIR 546
+ Q + ++ ++ E +Q + + E +K LE + K E L++
Sbjct: 1419 EEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQ 1471
Score = 62.8 bits (151), Expect = 9e-10
Identities = 64/259 (24%), Positives = 121/259 (46%), Gaps = 36/259 (13%)
Query: 320 RQRRKELRKKQLAEQEELERQMKELQAANESKQ-QELEAVRKKLEEAASRAAEEEKKRLQ 378
+Q R++ +K E+++L RQ ++ + E +Q + E RK LEE E +K +
Sbjct: 1406 QQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFRE 1465
Query: 379 TQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQ----RVRELEDMYLKLQEAL- 433
+ LQ R +L R++ R+ +EE+ + E ++ + R +E E +L+ ++ L
Sbjct: 1466 EEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLH 1525
Query: 434 ---------EDERQARQDEETVRKLQ--ARLLEEESSKRAELEKWHLEQQ---------- 472
++E+Q R+ E ++ Q R EE R E E+ L +Q
Sbjct: 1526 RQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEE 1585
Query: 473 QAIQTTEAEKQELENQRVLKEQALQEAMEQL--------EQLELER-KQALEQYEEVKKK 523
Q ++ E E++ +E+++ L+ Q Q+ + Q EQL ER +Q L + E +K
Sbjct: 1586 QKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKF 1645
Query: 524 LEMATNKTKSWKDKVAHHE 542
LE + +++ H+
Sbjct: 1646 LEEEPQLRRQEREQQLRHD 1664
Score = 62.8 bits (151), Expect = 9e-10
Identities = 62/238 (26%), Positives = 114/238 (47%), Gaps = 33/238 (13%)
Query: 317 KEARQRRKELRKKQLAEQE------------------ELERQMKELQAANESKQQELEAV 358
+E +Q R++ R ++ EQE +RQ K LQ + ++QE
Sbjct: 1489 EEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQ 1548
Query: 359 RKKLEEAASRAAEE-EKKRLQTQVELQAR-FSTELEREKLIRQQMEEQVAQKSSEL--EQ 414
R++ + R E+ ++R + Q+ Q R LE +K+ RQ+ E + + +L ++
Sbjct: 1549 RRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQE 1608
Query: 415 YLQRVRELEDMYLKLQEALEDERQARQ--DEETVRKL-----QARLLEEESSKRAELEKW 467
Q++R+ D + E L ER+ +Q +E RK Q R E E R + ++
Sbjct: 1609 GQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRK 1668
Query: 468 HLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVKKKLE 525
E++Q +Q E E+Q+L Q +++ +E +QL + E ERK E+ + +++LE
Sbjct: 1669 FREEEQLLQ--EGEEQQLRRQE--RDRKFREEEQQLRRQERERKFLQEEQQLRRQELE 1722
Score = 60.5 bits (145), Expect = 4e-09
Identities = 56/228 (24%), Positives = 111/228 (48%), Gaps = 10/228 (4%)
Query: 317 KEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKK- 375
++ R+ ++E R+++L +EE ER + L+ +E +++E E ++ E+A R K
Sbjct: 645 QQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKW 704
Query: 376 RLQTQVELQARFSTELEREKLI-----RQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQ 430
+ Q + E AR S R + RQ+ EE+ ++ SEL+ + + + +
Sbjct: 705 QWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQR 764
Query: 431 EALEDERQARQDEETVR-KLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQR 489
+ QA + E R +L AR E +R + +++Q E EK++ QR
Sbjct: 765 RDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQR 824
Query: 490 VLKEQALQEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSWKDK 537
+E+ LQ +E+ EQL+ R++ +Q +E + L+ + +S + +
Sbjct: 825 REREKELQ-FLEEEEQLQ--RRERAQQLQEEEDGLQEDQERRRSQEQR 869
Score = 54.3 bits (129), Expect = 3e-07
Identities = 48/203 (23%), Positives = 103/203 (50%), Gaps = 12/203 (5%)
Query: 320 RQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASR-AAEEEKKRLQ 378
++ R+E R K+ E+ E ER+ + L++ + ++++ + R++ E R EEE++RL+
Sbjct: 612 QEERREQRLKR--EEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLE 669
Query: 379 TQVEL---QARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALED 435
+++ + R EL E+ ++Q E++ + + + L+ + + + ++
Sbjct: 670 QRLKREHEEERREQELAEEE--QEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQE 727
Query: 436 ERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAI--QTTEAEKQELENQRVLKE 493
++ RQ++E R+ + L+ + +RA ++ EQ++ Q EK E QR+
Sbjct: 728 GQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSAR 787
Query: 494 QALQEAMEQLEQLELERKQALEQ 516
L+E E+ QL E +Q EQ
Sbjct: 788 PPLREQRER--QLRAEERQQREQ 808
Score = 51.2 bits (121), Expect = 3e-06
Identities = 51/198 (25%), Positives = 96/198 (48%), Gaps = 31/198 (15%)
Query: 348 NESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQME----E 403
+E K+ + L++ R EE+++R + + + R+K Q+ E E
Sbjct: 96 DEEKRARCDGKESLLQD---RRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGE 152
Query: 404 QVAQKSSELEQYLQRVRELEDMYLKLQEALE-DERQARQ---------------DEETVR 447
+ ++K LEQ R R E+++ + QE E +ER+A + DEE +R
Sbjct: 153 EQSEKQERLEQ-RDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLR 211
Query: 448 KLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLE 507
+ + LLE R E ++ E+Q + E EK+ + + VL+++ E+L++ E
Sbjct: 212 RRE--LLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEE-----EKLQEEE 264
Query: 508 LERKQALEQYEEVKKKLE 525
+R++ L++ EE +KLE
Sbjct: 265 PQRQRELQEEEEQLRKLE 282
Score = 42.7 bits (99), Expect = 0.001
Identities = 40/160 (25%), Positives = 79/160 (49%), Gaps = 12/160 (7%)
Query: 388 STELEREKLIRQQMEEQVAQKSSELE---QYLQRVRELEDM--YLKLQEALEDERQARQD 442
+T L+ EK R +E + Q + E ++ R R+LE+ + Q+ E ER+ +
Sbjct: 92 ATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEG 151
Query: 443 EETVRKLQARLLEEESSKRAELEKWHLEQQ-QAIQTTEAEKQELENQR--VLKEQALQEA 499
EE K + LE+ +R + E W Q+ Q + AE+++L++ + +E +E
Sbjct: 152 EEQSEKQER--LEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQ 209
Query: 500 MEQLEQLELERKQALEQYEEVKKKLE--MATNKTKSWKDK 537
+ + E LEL RK E+ ++ +++ + + K W+ +
Sbjct: 210 LRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKR 249
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 84.3 bits (207), Expect = 3e-16
Identities = 70/303 (23%), Positives = 147/303 (48%), Gaps = 20/303 (6%)
Query: 286 ISASDKKKKQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQEELERQMKELQ 345
++ S+K + Q ++ + + K P Q ++++L EQE+ R+ +E
Sbjct: 198 LAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKM 257
Query: 346 AANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQV 405
E + +E E ++ EE R ++KRL+ Q + EL +K +R+Q EEQ+
Sbjct: 258 WRQEERLREQEGKMREQEEKMRR----QEKRLREQEKELREQEKELREQKKLREQ-EEQM 312
Query: 406 AQKSSELEQYLQRVRELEDMYLKLQEAL-EDERQARQDEETVRKLQARLLEEESSKRAEL 464
++ ++ + +++RE E+ + +E L E E+Q R+ E+ +R + R+ E++ R +
Sbjct: 313 QEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKE 372
Query: 465 EKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAM-EQLEQLELERKQALEQYEEVKKK 523
E+ +++ Q + +++E +R K + +E M EQ E+++ + + EQ E+ ++
Sbjct: 373 ERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQ 432
Query: 524 LEMATNKTKSW-KDKVAHHEGLIRLIEPGSKNPHLITNWGPAAFTEAELEEREKNWKEKK 582
+ K K W ++K+ E ++ E K WG + +K W+++K
Sbjct: 433 QRLPEQKEKLWEQEKMQEQEE--KIWEQEEKIRDQEEMWG----------QEKKMWRQEK 480
Query: 583 TTE 585
E
Sbjct: 481 MRE 483
Score = 70.9 bits (172), Expect = 3e-12
Identities = 70/284 (24%), Positives = 130/284 (45%), Gaps = 45/284 (15%)
Query: 316 HKEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKK 375
HK+A + +EL K++ A EL R N +EL+ +L+E R AE EK
Sbjct: 154 HKKADRYIEELTKERDALSLELYR--------NTITNEELKKKNAELQEKL-RLAESEKS 204
Query: 376 RLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALED 435
+Q V+ R +LER K + Q++ Q E+M+ + +E E
Sbjct: 205 EIQLNVKELKR---KLERAKFLLPQVQTNTLQ---------------EEMWRQEEELREQ 246
Query: 436 ERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAE----KQELENQRVL 491
E++ R+ EE + + + RL E+E R + EK Q++ ++ E E ++EL Q+ L
Sbjct: 247 EKKIRKQEEKMWRQEERLREQEGKMREQEEKMR-RQEKRLREQEKELREQEKELREQKKL 305
Query: 492 KEQALQEAMEQLEQLELERKQALEQYE-----------EVKKKLEMATNKTKSWKDKVAH 540
+EQ +E M++ E+ E+++ + + E E +K++ K + ++++
Sbjct: 306 REQ--EEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWE 363
Query: 541 HEGLIRLIEPGSKNPHLITNWGPAAFTEAELEEREKNWKEKKTT 584
+ +R E + + E + EREK +E++ T
Sbjct: 364 QDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEET 407
Score = 70.1 bits (170), Expect = 5e-12
Identities = 57/237 (24%), Positives = 124/237 (52%), Gaps = 18/237 (7%)
Query: 317 KEARQRRKELRKKQLAEQEELERQMKELQAA------NESKQQELEAVR---KKLEEAAS 367
+E +R +E +K++ +QEE R+ K+ Q E K +E E +R KK+ E
Sbjct: 517 REKEERMRE--QKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEE 574
Query: 368 RAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQ-RVRELEDMY 426
E+E+K + + +++ + E+E+ +++Q E+ Q+ EQ + +++E E+M
Sbjct: 575 MMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMM 634
Query: 427 LKLQEAL-EDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQEL 485
+ +E + E E + + EE +R+ + ++ E+E + + EK EQ++ +Q E + +E
Sbjct: 635 WEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMR-EQEEKMQGQEEKMREQ 693
Query: 486 ENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSWKDKVAHHE 542
E K + +E M E+ +++ + EE+++K E ++ + ++++ HE
Sbjct: 694 EE----KMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQERLPEHE 746
Score = 69.3 bits (168), Expect = 9e-12
Identities = 62/255 (24%), Positives = 129/255 (50%), Gaps = 30/255 (11%)
Query: 317 KEARQRRKELRKKQLAEQEELERQMKELQAANES--KQQELEAVRKKL-------EEAAS 367
KE +Q+R +K++L EQE+++ Q +++ E Q+E+ KK+ E+
Sbjct: 428 KEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQ 487
Query: 368 RAAEEEKKRLQTQV-----------ELQARFSTELEREKLIRQQMEEQVAQKSSELEQYL 416
+EEK R Q Q + + R E RE+ Q EE++ ++ EQ
Sbjct: 488 MWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQE- 546
Query: 417 QRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEK-WHLEQQQAI 475
++ + E+ + + E E++ R++EE +R+ + ++ E+E R + EK W EQ++ +
Sbjct: 547 KKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMW--EQEEKM 604
Query: 476 QTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQALEQYE----EVKKKLEMATNKT 531
Q E E++ E + + EQ ++ M++ E++ E+++ +++ E E ++K+ K
Sbjct: 605 Q--EQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKM 662
Query: 532 KSWKDKVAHHEGLIR 546
+ ++K+ E +R
Sbjct: 663 REQEEKMQGQEEKMR 677
Score = 65.5 bits (158), Expect = 1e-10
Identities = 66/306 (21%), Positives = 135/306 (44%), Gaps = 45/306 (14%)
Query: 321 QRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVR---------------KKLEEA 365
Q KE ++++L EQ+E + +++Q E ++ E +R +K+ E
Sbjct: 425 QEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQ 484
Query: 366 ASRAAEEEKKRLQTQVEL------------QARFSTELEREKLIRQQMEEQVAQKSSELE 413
+ E+E+K + ++ + R E RE+ Q EE++ ++ E
Sbjct: 485 EDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQE 544
Query: 414 QYL------------QRVRELEDMYLKLQEAL-EDERQARQDEETVRKLQARLLEEESSK 460
Q +R+RE E + +E + E E + ++ EE +R+ + ++ E+E
Sbjct: 545 QEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKM 604
Query: 461 RAELEK-WHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQALEQYEE 519
+ + EK W E++ Q E + QE E +E+ +QE E++ + E + ++ E+ E
Sbjct: 605 QEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMRE 664
Query: 520 VKKKLEMATNKTKSWKDKVAHHEGLIRLIEPGSKNPHLITNWGPAAFTEAELEEREKNWK 579
++K++ K + ++K+ E +R E + WG E + EK W
Sbjct: 665 QEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQE-EKMWGQ---EEKMWGQEEKMWG 720
Query: 580 EKKTTE 585
+++ E
Sbjct: 721 QEEMRE 726
Score = 64.7 bits (156), Expect = 2e-10
Identities = 58/261 (22%), Positives = 121/261 (46%), Gaps = 44/261 (16%)
Query: 317 KEARQRRKELRKKQ---------LAEQEELERQMKELQAANESKQQELEAVR---KKLEE 364
K+ R++ +++R ++ L E+EE R+ +++ E K QE E +R KK+ E
Sbjct: 345 KQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWE-QEEKMQEEERIREREKKMRE 403
Query: 365 AASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYL-------- 416
E+E+K + + + + E ++++L Q+ + +K E E+ +
Sbjct: 404 EEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIR 463
Query: 417 ---------------QRVRELEDMYLKLQEALEDERQARQD-EETVRKLQARLLEEESSK 460
+++RE ED + +E + D+ Q D EE + + RL E+E
Sbjct: 464 DQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERM 523
Query: 461 RAELEKWHLEQ--QQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQALEQYE 518
R + + W E+ ++ +T E EK+ + + ++E +E M + E+ E ++ + + E
Sbjct: 524 REQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMRE---EERMREREKKMREEEEMMREQE 580
Query: 519 EVKKKLE--MATNKTKSWKDK 537
E ++ E M + K W+ +
Sbjct: 581 EKMQEQEEKMREQEEKMWEQE 601
Score = 62.8 bits (151), Expect = 9e-10
Identities = 57/237 (24%), Positives = 118/237 (49%), Gaps = 24/237 (10%)
Query: 317 KEARQRRKEL---RKKQLAEQEELERQMKELQAANESKQQELEAVRKKLE--------EA 365
KE R R +E +++++ E+E + + K+++ E+ +++ E ++K+ E E
Sbjct: 371 KEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEW 430
Query: 366 ASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDM 425
+ E+K++L Q ++Q + E+E+ IR Q EE Q+ Q +++RE ED
Sbjct: 431 QQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQ-EEMWGQEKKMWRQ--EKMREQED- 486
Query: 426 YLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQEL 485
+ E E + R E+ + + R+ E++ R + E+ EQ++ Q E ++E
Sbjct: 487 -----QMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMR-EQKKMWQQEEKMREEK 540
Query: 486 ENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSWKDKVAHHE 542
+ Q K+ QE + E+ ER++ + + EE+ ++ E K + ++K+ E
Sbjct: 541 KTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQE---EKMQEQEEKMREQE 594
Score = 62.0 bits (149), Expect = 1e-09
Identities = 48/228 (21%), Positives = 118/228 (51%), Gaps = 24/228 (10%)
Query: 320 RQRRKELRKKQLAEQEELERQMKEL-----QAANESKQQELEAVRKKLEEAASRAAEEEK 374
R+R K++R+++ +E+ E+ K+ Q E +QQ L ++KL E +EEK
Sbjct: 395 REREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEK 454
Query: 375 -----KRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKL 429
++++ Q E+ + +EK+ ++ E+Q+ ++ ++ Q++ + E+ +
Sbjct: 455 IWEQEEKIRDQEEMWGQEKKMWRQEKM--REQEDQMWEQEEKMRDQEQKMWDQEERMWEQ 512
Query: 430 QEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQ--QAIQTTEAEKQELEN 487
E L ++ + ++++ + + + ++ EE+ ++ E + W E++ + + E EK+ E
Sbjct: 513 DERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREE 572
Query: 488 QRVLKEQA---------LQEAMEQL-EQLELERKQALEQYEEVKKKLE 525
+ +++EQ ++E E++ EQ E ++Q + +E+ +K E
Sbjct: 573 EEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWE 620
Score = 61.6 bits (148), Expect = 2e-09
Identities = 64/319 (20%), Positives = 142/319 (44%), Gaps = 59/319 (18%)
Query: 317 KEARQRRKELRKKQ----------------------LAEQE-----------ELERQMKE 343
KE R++ KELR+++ + EQE E E+QM+E
Sbjct: 290 KELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMRE 349
Query: 344 LQAANESKQQELEAVRKKLEEAASRAAEEEK-----KRLQTQVELQARFSTELEREKLIR 398
+ +++ + ++L E R E+EK +++Q + ++ R E E+ +R
Sbjct: 350 QEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMR 409
Query: 399 QQMEEQVAQKSS-----ELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRK----- 448
+Q E+ Q+ + E E QR+ E ++ + ++ E E + + EE +R
Sbjct: 410 EQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMW 469
Query: 449 -LQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLE 507
+ ++ +E + E + W EQ++ ++ E + + E + +++ L+E E++
Sbjct: 470 GQEKKMWRQEKMREQEDQMW--EQEEKMRDQEQKMWDQEERMWEQDERLREKEERMR--- 524
Query: 508 LERKQALEQYEEVKKKLEMATNKTKSW-KDKVAHHEGLIRLIEPGSKNPHLITNWGPAAF 566
E+K+ +Q E+++++ + + K+W +++ E +R E + +
Sbjct: 525 -EQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKM 583
Query: 567 TEAE---LEEREKNWKEKK 582
E E E+ EK W++++
Sbjct: 584 QEQEEKMREQEEKMWEQEE 602
Score = 61.6 bits (148), Expect = 2e-09
Identities = 46/204 (22%), Positives = 111/204 (54%), Gaps = 23/204 (11%)
Query: 320 RQRRKELRKKQ--LAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRL 377
R+R K++R+++ + EQEE ++ +E E K E E +K++E + E+E+K
Sbjct: 563 REREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQE---EKMQEQEEKMWEQEEKMW 619
Query: 378 QTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALE-DE 436
+ + E + + E+E+++ +Q EE++ ++ ++ + +++RE E+ + +E ++ E
Sbjct: 620 EQEEEDKMQ-----EQEEMMWEQ-EEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQE 673
Query: 437 RQARQDEETVRKLQARLLEEESSKRAELEK-WHLEQQQAIQTTEAEKQELENQRVLKEQA 495
+ R+ EE ++ + ++ E+E R + EK W E EK + +++ ++
Sbjct: 674 EKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQE----------EKMWGQEEKMWGQEE 723
Query: 496 LQEAMEQLEQLELERKQALEQYEE 519
++E E++ + + ++ L ++EE
Sbjct: 724 MREKEERIRDQKEKMQERLPEHEE 747
Score = 30.8 bits (68), Expect = 3.6
Identities = 24/127 (18%), Positives = 61/127 (48%), Gaps = 8/127 (6%)
Query: 317 KEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAE-EEKK 375
++ Q ++E+ +Q + +E E +M E + +++++ +K++ + E EEK
Sbjct: 624 EDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKM 683
Query: 376 RLQTQVELQARFSTELEREKLIRQQM----EEQVAQKSSELEQYLQRVRELEDMYLKLQE 431
+ Q + + + EK+ Q+ +E+ E+ + +R+R+ ++ K+QE
Sbjct: 684 QGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKE---KMQE 740
Query: 432 ALEDERQ 438
L + +
Sbjct: 741 RLPEHEE 747
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 80.5 bits (197), Expect = 4e-15
Identities = 85/357 (23%), Positives = 177/357 (49%), Gaps = 40/357 (11%)
Query: 263 ESLPDKDGK--KCLFLVKCFDKTFEISASDKKKK---------QEWIQAIHSTIHLLK-L 310
E L +K+ K + L LV+ +++ + K+K Q+ +QA HL K L
Sbjct: 217 EELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQA--EADHLGKEL 274
Query: 311 GSPPPHKEARQRRKELRKKQLAEQEE-LERQMKELQAANESKQQELEAVR------KKLE 363
S +A+ EL + +QEE + RQ +++Q E Q++ E +R ++ E
Sbjct: 275 QSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQE 334
Query: 364 EAASRAAE---EEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVR 420
E R E E++++++ Q E+ ++ R++ + + EE++ ++ + + +++R
Sbjct: 335 EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIR 394
Query: 421 ELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEA 480
ELE+ + QE + ++ + RQ+EE +R+ + R +E+ +K E+ EQ++ I+ E
Sbjct: 395 ELEEK-MHEQEKIREQEEKRQEEEKIREQEKR--QEQEAKMWRQEEKIREQEEKIREQE- 450
Query: 481 EKQELENQRVLKEQALQEAMEQLEQLELERKQA-LEQYEEV---KKKLEMATNKTKSWKD 536
+K + +++ +++ ++E ++ EQ E+ R++ + + EE+ K+K+ K + ++
Sbjct: 451 KKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEE 510
Query: 537 KVAHHEGLIRLIEPGSKNPH--------LITNWGPAAFTEAELEEREKNWKEKKTTE 585
KV E IR E + I E ++ E+EK W+E+K E
Sbjct: 511 KVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQE 567
Score = 80.1 bits (196), Expect = 5e-15
Identities = 58/242 (23%), Positives = 130/242 (53%), Gaps = 22/242 (9%)
Query: 317 KEARQRRKEL--RKKQLAEQEELERQMKELQAANESKQQELEAV---RKKLEEAASRAAE 371
+E RQ ++E+ +++++ EQEE+ RQ +++ E +++ E V +K+ E + E
Sbjct: 469 EEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIRE 528
Query: 372 EEKKRLQTQVELQARFSTELEREKLIRQQM---EEQVAQKSSELEQYLQRVRELEDMYLK 428
+E+K + + +++ + E EK+ Q+ EE+ ++ ++ + +++RE E+ +
Sbjct: 529 QEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWR 588
Query: 429 LQEALEDERQARQD--------EETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEA 480
+E + ++ + RQ+ EE +R+ + ++ E+E R + EK EQ++ Q E
Sbjct: 589 QEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIR-EQEEMTQEQEE 647
Query: 481 EKQELENQRVLKEQALQEAME----QLEQLELERKQALEQYEEVKKKLE-MATNKTKSWK 535
+ E E + +E+ +QE E Q E++ + K+ EQ E+++++ E M + K W+
Sbjct: 648 KMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWE 707
Query: 536 DK 537
+
Sbjct: 708 QE 709
Score = 79.7 bits (195), Expect = 7e-15
Identities = 65/283 (22%), Positives = 141/283 (49%), Gaps = 18/283 (6%)
Query: 318 EARQRRKELRKKQLAEQEEL----ERQMKELQAANESKQQELEA----VRKKLEEAASRA 369
E ++ +EL +K + EQE++ E++ +E + + K+QE EA +K+ E +
Sbjct: 388 EKEEKIRELEEK-MHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKI 446
Query: 370 AEEEKK--RLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYL 427
E+EKK R + ++ Q + E +R++ +E+ + E+ + +++ E E+
Sbjct: 447 REQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIR 506
Query: 428 KLQEAL-EDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQT---TEAEKQ 483
K +E + E + R+ EE +R+ + ++ +E R + E W E++ Q E ++Q
Sbjct: 507 KQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQ 566
Query: 484 ELENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSWKDKVAHHEG 543
E E++ +E+ ++E E++ + E + ++ E+ +E ++K+ K + ++K+ E
Sbjct: 567 EQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEE 626
Query: 544 LIRLIEPGSKNPHLITNWGPAAFTEAE---LEEREKNWKEKKT 583
IR E + +T E E E+ EK ++++T
Sbjct: 627 KIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEET 669
Score = 71.6 bits (174), Expect = 2e-12
Identities = 50/226 (22%), Positives = 119/226 (52%), Gaps = 7/226 (3%)
Query: 317 KEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKR 376
+EA+ R+E +++ EQEE R+ ++ E K E E +R++ + ++++
Sbjct: 428 QEAKMWRQE---EKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEK 484
Query: 377 LQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDE 436
+ Q E+ + E+E+ IR+Q EE+V ++ ++ + +++RE E+ + +E + ++
Sbjct: 485 IHEQEEIWRQKEKMHEQEEKIRKQ-EEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQ 543
Query: 437 RQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQAL 496
+ ++EE + + Q ++ EEE + E + W E++ Q + +QE + + +E+
Sbjct: 544 EEMWREEEKMHE-QEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIRE--QEEKR 600
Query: 497 QEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSWKDKVAHHE 542
QE E++ + E + ++ E+ +E ++K+ K + ++ E
Sbjct: 601 QEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQE 646
Score = 70.5 bits (171), Expect = 4e-12
Identities = 65/307 (21%), Positives = 150/307 (48%), Gaps = 20/307 (6%)
Query: 288 ASDKKKKQEWIQAIHSTIHLLKLG---SPPPHKEARQRRKELRKK-QLAEQEELERQMKE 343
A+ KKK +I+ + L L + +E +++ +L++K QL E E+ E Q+
Sbjct: 185 ATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNV 244
Query: 344 LQAANESKQQELEAVRKKLEEAASRAAEEEKK---RLQTQVELQARFSTELEREKLIRQQ 400
+ + ++ +L +++L+ A +E + +LQ QVE E E + QQ
Sbjct: 245 KELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVE-------ENELWNRLNQQ 297
Query: 401 MEEQVAQKSSELEQYLQRVRELEDMYLKLQEAL-EDERQARQDEETVRKLQARLLEEESS 459
EE++ ++ +++++ ++++E E+ + +E + E E + R+ EE + + + ++ +E
Sbjct: 298 QEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEM 357
Query: 460 KRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQALEQYEE 519
+ EK Q++ + E + + E KE+ ++E E++ + E R+Q ++ EE
Sbjct: 358 MWEKEEKMR-RQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEE 416
Query: 520 --VKKKLEMATNKTKSWK--DKVAHHEGLIRLIEPGSKNPHLITNWGPAAFTEAELEERE 575
++++ + + K W+ +K+ E IR E + E + +E+E
Sbjct: 417 EKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQE 476
Query: 576 KNWKEKK 582
+ W++++
Sbjct: 477 EMWRQEE 483
Score = 70.1 bits (170), Expect = 5e-12
Identities = 74/318 (23%), Positives = 154/318 (48%), Gaps = 45/318 (14%)
Query: 293 KKQEWIQAIHSTIH---LLKLGSPPPHKEARQRRKELRKKQLAE---QEELERQMKELQA 346
+K+E I+ + +H ++ +E + R +E R++Q A+ QEE R+ +E
Sbjct: 388 EKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIR 447
Query: 347 ANESK---QQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEE 403
E K Q+E ++K+ E R +EE R + ++ Q E+ R+K + EE
Sbjct: 448 EQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQE----EIWRQKEKMHEQEE 503
Query: 404 QVAQKSSELEQYLQRVRELEDMYLKLQEAL-EDERQARQDEETVRK-----LQARLLEEE 457
++ ++ ++ + +++RE E+ + +E + E + R+ EE R+ Q ++ EEE
Sbjct: 504 KIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEE 563
Query: 458 SSKRAELEKWHLE------------QQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQ 505
+ E + W E Q++ I+ E ++QE E + +E+ ++E E++++
Sbjct: 564 KRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQE 623
Query: 506 LELERKQALEQYEEVKKKLEMATNKTKSWKDKVAHHEGLIRLIEPGSK-NPHLITNWGPA 564
E ++ EQ E+++++ EM T+ ++K+ E ++ E K T W
Sbjct: 624 QE---EKIREQEEKIREQEEM----TQEQEEKMGEQEE--KMCEQEEKMQEQEETMWR-- 672
Query: 565 AFTEAELEEREKNWKEKK 582
E ++ E+EK +E++
Sbjct: 673 --QEEKIREQEKKIREQE 688
Score = 69.7 bits (169), Expect = 7e-12
Identities = 56/266 (21%), Positives = 131/266 (49%), Gaps = 21/266 (7%)
Query: 317 KEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKR 376
KE + RR+E + + E+EE R+ +E+ E K + E + + EE E+ ++
Sbjct: 347 KEEKMRRQE---EMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQ 403
Query: 377 LQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDE 436
+ + + + R E RE+ RQ+ E ++ ++ ++ + +++RE E + +E + ++
Sbjct: 404 EKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQ 463
Query: 437 RQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQAL 496
+ R++E+ R+ Q + +E + E W +++ Q + KQE ++V +++
Sbjct: 464 EKIREEEK--RQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQE---EKVWRQE-- 516
Query: 497 QEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSWKDKVAHHEGLIRLIEPGSKNPH 556
++ EQ E++ + ++ Q E+++++ EM W+++ HE ++ E +
Sbjct: 517 EKIREQEEKIREQEEKMWRQEEKIREQEEM-------WREEEKMHE-QEKIWEEEKRQEQ 568
Query: 557 LITNWGPAAFTEAELEEREKNWKEKK 582
W E E+ EK W++++
Sbjct: 569 EDKMWRQ---EEKIREQEEKVWRQEE 591
Score = 69.3 bits (168), Expect = 9e-12
Identities = 52/212 (24%), Positives = 113/212 (53%), Gaps = 21/212 (9%)
Query: 327 RKKQLAEQEELERQMKELQAA----NESKQQELE----AVRKKLEEAASRAAEEEKKRLQ 378
+++++ EQEE+ R+ +++ E K+QE E +K+ E + +E+K +
Sbjct: 536 QEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIRE 595
Query: 379 TQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEAL----- 433
+ + Q + ++E+ IR+Q EE++ ++ ++ + +++RE E+M + +E +
Sbjct: 596 QEEKRQEQEEKMWKQEEKIREQ-EEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEE 654
Query: 434 ---EDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRV 490
E E + ++ EET+ + + ++ E+E R + EK EQ++ +Q E + E E +
Sbjct: 655 KMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIR-EQEEMMQEQEEKMWEQEEKMC 713
Query: 491 LKEQALQEAMEQLEQLE---LERKQALEQYEE 519
+E+ +QE E++ + E E++ L Q EE
Sbjct: 714 EQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEE 745
Score = 68.2 bits (165), Expect = 2e-11
Identities = 48/226 (21%), Positives = 120/226 (53%), Gaps = 8/226 (3%)
Query: 317 KEARQRRKELRKKQ--LAEQEELERQMKELQAANES--KQQELEAVRKKLEEAASRAAEE 372
++ R++ +++R+++ + QEE R+ +E+ E +Q+++ K+ E+ +E
Sbjct: 517 EKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQE 576
Query: 373 EKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEA 432
EK ++ Q E R ++ ++ RQ+ EE++ ++ ++ + ++++E E+ + +E
Sbjct: 577 EK--IREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEK 634
Query: 433 LEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLK 492
+ ++ + Q++E Q + E+ K E E+ Q++ I+ E + +E E + +
Sbjct: 635 IREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQ 694
Query: 493 EQALQEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSWKDKV 538
E+ +QE E++ + E + + E+ +E ++K M + K W+ +V
Sbjct: 695 EEMMQEQEEKMWEQEEKMCEQEEKMQEQEEK--MRRQEEKMWEQEV 738
Score = 64.7 bits (156), Expect = 2e-10
Identities = 51/200 (25%), Positives = 110/200 (55%), Gaps = 14/200 (7%)
Query: 316 HKEARQRRKELRKKQ---LAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEE 372
H++ + +E R++Q + QEE R+ +E E K +E E R++ EE + +E
Sbjct: 554 HEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWK--QE 611
Query: 373 EKKRLQTQVELQARFSTELEREKLIR------QQMEEQVAQKSSELEQYLQRVRELEDMY 426
EK R Q + ++Q + E+E+ IR Q+ EE++ ++ ++ + ++++E E+
Sbjct: 612 EKIREQEE-KIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETM 670
Query: 427 LKLQEAL-EDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQEL 485
+ +E + E E++ R+ EE +R+ Q +++E+ K E E+ EQ++ +Q E + +
Sbjct: 671 WRQEEKIREQEKKIREQEEKIRE-QEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQ 729
Query: 486 ENQRVLKEQALQEAMEQLEQ 505
E + +E L++ E++++
Sbjct: 730 EEKMWEQEVRLRQQEEKMQE 749
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 80.5 bits (197), Expect = 4e-15
Identities = 54/233 (23%), Positives = 123/233 (52%), Gaps = 14/233 (6%)
Query: 318 EARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRL 377
+ R+ + + +++++ EQEE R+ +E+ E K + E + + EE E+ ++
Sbjct: 298 QEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQE 357
Query: 378 QTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEAL---- 433
+ + + + R E RE+ RQ+ E ++ ++ ++ + +++RE E+M + +E +
Sbjct: 358 KIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQE 417
Query: 434 ----EDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQR 489
E E + ++ EE +R+ + ++ E+E R + EK EQ++ +Q E + E E +
Sbjct: 418 EKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIR-EQEEMMQEQEEKMGEQEGKM 476
Query: 490 VLKEQALQEAMEQL----EQLELERKQALEQYEEVKKKLE-MATNKTKSWKDK 537
+E +QE E++ E++ + K+ EQ E+++++ E M + K W+ +
Sbjct: 477 CEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQE 529
Score = 77.4 bits (189), Expect = 3e-14
Identities = 57/241 (23%), Positives = 125/241 (51%), Gaps = 30/241 (12%)
Query: 293 KKQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQEELERQMKELQAANESKQ 352
+K+E I+ + +H K Q K ++++ EQE+ + Q ++ E +
Sbjct: 341 EKEEKIRELEEKMH-------EQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIR 393
Query: 353 QELEAVRKK---LEEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKS 409
++ E +R++ ++E + E+E+K + + E+Q E+E+ +R+Q EE++ ++
Sbjct: 394 EQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQ-------EQEEKMRRQ-EEKIREQE 445
Query: 410 SELEQYLQRVRELEDMYLKLQEAL--------EDERQARQDEETVRKLQARLLEEESSKR 461
++ + +++RE E+M + +E + E E + ++ EE +R+ + ++ E+E R
Sbjct: 446 KKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIR 505
Query: 462 AELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLE---LERKQALEQYE 518
+ EK EQ++ +Q E + E E + +E+ +QE E++ + E E++ L Q E
Sbjct: 506 EQEEKIR-EQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQE 564
Query: 519 E 519
E
Sbjct: 565 E 565
Score = 75.5 bits (184), Expect = 1e-13
Identities = 70/330 (21%), Positives = 159/330 (48%), Gaps = 43/330 (13%)
Query: 288 ASDKKKKQEWIQAIHSTIHLLKLG---SPPPHKEARQRRKELRKK-QLAEQEELERQM-- 341
A+ KKK +I+ + L L + +E +++ +L++K QL E E+ E Q+
Sbjct: 173 ATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNV 232
Query: 342 ----------------KELQAANESKQQELEAVRKKLE------EAASRAAEEEKKRLQT 379
++LQA + +EL++V KL+ E +R +++++++
Sbjct: 233 KELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWR 292
Query: 380 QVE-LQARFSTELEREKLIRQQ------MEEQVAQKSSELEQYLQRVRELEDMYLKLQEA 432
Q E +Q R E+E+ IR+Q EE + +K ++ + + + E E+ +L+E
Sbjct: 293 QEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEK 352
Query: 433 LEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLK 492
+ ++ + R+ EE R+ + ++ E+E + E + W Q++ I+ E + +E E +
Sbjct: 353 MHEQEKIREQEEK-RQEEEKIREQEKRQEQEAKMW--RQEEKIREQEEKIREQEEMMQEQ 409
Query: 493 EQALQEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSWKDKVAHHEGLIRLIEPGS 552
E+ + E E++ + E E ++ E+ ++K+ K + ++K+ E +++
Sbjct: 410 EEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQ-----E 464
Query: 553 KNPHLITNWGPAAFTEAELEEREKNWKEKK 582
+ + G EA+++E+E+ + ++
Sbjct: 465 QEEKMGEQEGKMCEQEAKMQEQEEKMRRQE 494
Score = 72.4 bits (176), Expect = 1e-12
Identities = 55/231 (23%), Positives = 123/231 (53%), Gaps = 19/231 (8%)
Query: 318 EARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRL 377
E ++ +EL +K + EQE++ Q ++ Q + ++QE K+ E+ A +EEK R
Sbjct: 341 EKEEKIRELEEK-MHEQEKIREQEEKRQEEEKIREQE-----KRQEQEAKMWRQEEKIRE 394
Query: 378 QTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEAL-EDE 436
Q + ++ ++ + Q+ EE++ ++ ++ + + ++E E+ + +E + E E
Sbjct: 395 QEE---------KIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQE 445
Query: 437 RQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQAL 496
++ R+ EE +R+ Q +++E+ K E E EQ+ +Q E + + E + +E+ +
Sbjct: 446 KKIREQEEKIRE-QEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKI 504
Query: 497 QEAMEQL-EQLELERKQALEQYEEVKKKLEMATNKTKSWKDKVAHHEGLIR 546
+E E++ EQ E+ ++Q + +E+ +K E K + ++K+ E +R
Sbjct: 505 REQEEKIREQEEMMQEQEEKMWEQEEKMCEQ-EEKMQEQEEKMRRQEEKMR 554
Score = 69.7 bits (169), Expect = 7e-12
Identities = 82/348 (23%), Positives = 160/348 (45%), Gaps = 50/348 (14%)
Query: 263 ESLPDKDGK--KCLFLVKCFDKTFEISASDKKKK---------QEWIQAIHSTIHLLK-L 310
E L +K+ K + L LV+ +++ + K+K Q+ +QA HL K L
Sbjct: 205 EELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQA--EADHLGKEL 262
Query: 311 GSPPPHKEARQRRKELRKKQLAEQEE-LERQMKELQAANESKQQELEAVRKKLEEAASRA 369
S +A+ EL + +QEE + RQ +++Q E Q++ E +R++ EE R
Sbjct: 263 QSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQ-EEKMRRQ 321
Query: 370 AE-----EEKKRLQTQV---------ELQARF-STELEREKLIRQQMEEQVAQKSSELEQ 414
E EEK R Q ++ EL+ + E RE+ ++Q EE++ ++ EQ
Sbjct: 322 EEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQ 381
Query: 415 YLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQA 474
+ R+ E + + ++ E E ++ EE + + + ++ E+E + + EK Q++
Sbjct: 382 EAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMR-RQEEK 440
Query: 475 IQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSW 534
I+ E + +E E + +E+ +QE E++ + E + + + +E ++K+ K +
Sbjct: 441 IREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQ 500
Query: 535 KDKVAHHEGLIRLIEPGSKNPHLITNWGPAAFTEAELEEREKNWKEKK 582
+ K+ E IR E E E+ EK W++++
Sbjct: 501 EKKIREQEEKIREQE------------------EMMQEQEEKMWEQEE 530
Score = 68.6 bits (166), Expect = 2e-11
Identities = 49/196 (25%), Positives = 104/196 (53%), Gaps = 14/196 (7%)
Query: 317 KEARQRRKELR----KKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAE- 371
+EA+ R+E + ++++ EQEE+ ++ +E E K E E ++ EE R E
Sbjct: 381 QEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEK 440
Query: 372 --EEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKL 429
E++K+++ Q E E+E+++++Q E+ Q+ EQ + + E M +
Sbjct: 441 IREQEKKIREQEEKIR------EQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQE 494
Query: 430 QEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQR 489
++ E E++ R+ EE +R+ Q +++E+ K E E+ EQ++ +Q E + + E +
Sbjct: 495 EKIREQEKKIREQEEKIRE-QEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKM 553
Query: 490 VLKEQALQEAMEQLEQ 505
+E L++ E++++
Sbjct: 554 REQEVRLRQQEEKMQE 569
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 79.7 bits (195), Expect = 7e-15
Identities = 73/261 (27%), Positives = 132/261 (50%), Gaps = 47/261 (18%)
Query: 315 PHKEARQRRKELRKKQLAEQ-------EELERQMKELQAANESKQQELEAVRKKLEEAAS 367
P ++ RQR + LR+K+ AEQ E+ R+++E++ E + +++ R+++E+
Sbjct: 530 PKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMK- 588
Query: 368 RAAEEEKKRLQ---------TQVELQARFSTELEREKLIRQQMEEQVAQKSSELE----Q 414
EE+KK+++ T+ + R + E ++K ++MEE A++ E E +
Sbjct: 589 ---EEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLR 645
Query: 415 YLQRVRE-----------LEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAE 463
+LQ+ E E+ +L++A E +R A Q E+ R+ + R E +R E
Sbjct: 646 WLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERRE 705
Query: 464 LEKWHLEQQQAIQTTEAEKQELENQRVL--KEQALQEAMEQLEQLELERKQALEQ----- 516
E+ E+Q A Q E++ L+ +R L +E+AL+ EQL Q ELE K+ E+
Sbjct: 706 QERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQL-QRELEEKKKKEEQQRLA 764
Query: 517 ----YEEVKKKLEMATNKTKS 533
EE +KK + A +K+
Sbjct: 765 ERQLQEEQEKKAKEAAGASKA 785
Score = 57.4 bits (137), Expect = 4e-08
Identities = 50/187 (26%), Positives = 82/187 (43%), Gaps = 22/187 (11%)
Query: 263 ESLPDKDGKKCLFLVKCFDKTFEISASDKKKKQEWIQAIHSTIHLLKLGSPPPHKEARQR 322
E L ++ KK K + ++ ++ W+Q +L +E +
Sbjct: 612 ERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERL 671
Query: 323 RKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLE-EAASRAAEEEKKRLQTQV 381
RK K+LAEQ E ER+ +E + +Q+ E R++ E + A + E++RLQ +
Sbjct: 672 RKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAER 731
Query: 382 ELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQ 441
ELQ EREK +R Q E Q RELE+ K ++ ERQ ++
Sbjct: 732 ELQ-------EREKALRLQKE--------------QLQRELEEKKKKEEQQRLAERQLQE 770
Query: 442 DEETVRK 448
++E K
Sbjct: 771 EQEKKAK 777
>gi|221139761 zinc finger protein 853 [Homo sapiens]
Length = 659
Score = 79.3 bits (194), Expect = 9e-15
Identities = 61/264 (23%), Positives = 140/264 (53%), Gaps = 46/264 (17%)
Query: 299 QAIHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQEELERQMKELQAANESKQQEL--- 355
Q H ++H +L P + ++++L+ +Q+ EQ+ L++Q ++LQ +QQ L
Sbjct: 135 QEKHQSVHHQEL---KPELQLMHQQQQLQPQQVQEQQRLQQQQEQLQTQQAQEQQVLQQQ 191
Query: 356 EAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQ----VAQKSSE 411
E ++++++E + ++++++LQ Q LQ + + ++ + ++Q+++Q + Q+ +
Sbjct: 192 EQLQQQVQE--QQLLQQQQEQLQQQQLLQQQEQLQQQQFQQQQEQLQQQQQLLLLQQQGQ 249
Query: 412 LEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQ 471
L+Q L L+ +LQ+ L +++QA+ ++ + + Q +L +++ + + ++ L+Q
Sbjct: 250 LQQQL-----LQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQQLLQQQQEQLQQ 304
Query: 472 QQ------------------------AIQTTEAEKQELENQRVLKEQALQEAM-----EQ 502
QQ + Q E ++QELE Q+ L+ Q Q + E+
Sbjct: 305 QQLQPPPLEPEEEEEVELELMPVDLGSEQELEQQRQELERQQELERQQEQRQLQLKLQEE 364
Query: 503 LEQLELERKQALEQYEEVKKKLEM 526
L+QLE + +Q +Q E+ + +LE+
Sbjct: 365 LQQLEQQLEQQQQQLEQQEVQLEL 388
Score = 71.2 bits (173), Expect = 2e-12
Identities = 64/236 (27%), Positives = 135/236 (57%), Gaps = 37/236 (15%)
Query: 309 KLGSPPPHKEARQRRKELRKKQLAEQEELERQM-------KELQAANESKQ------QEL 355
+L P PH E +Q+ ++ ++QL++ ++ + Q ELQ ++ +Q QE
Sbjct: 108 QLQQPQPHLELQQQPQQDGQQQLSQLQQEKHQSVHHQELKPELQLMHQQQQLQPQQVQEQ 167
Query: 356 EAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEE----QVAQKSSE 411
+ ++++ E+ ++ A+E++ LQ Q +LQ +++ ++L++QQ E+ Q+ Q+ +
Sbjct: 168 QRLQQQQEQLQTQQAQEQQV-LQQQEQLQQ----QVQEQQLLQQQQEQLQQQQLLQQQEQ 222
Query: 412 LEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQ 471
L+Q Q+ ++ ++ + Q+ L ++Q +LQ +LL+++ +A+L++ LEQ
Sbjct: 223 LQQ--QQFQQQQEQLQQQQQLLLLQQQG--------QLQQQLLQQQ---QAQLQQQLLEQ 269
Query: 472 QQA-IQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVKKKLEM 526
QQA +Q +Q+ + Q+ ++Q LQ+ EQL+Q +L+ LE EE + +LE+
Sbjct: 270 QQAQLQQQLLLQQQEQLQQQQQQQLLQQQQEQLQQQQLQ-PPPLEPEEEEEVELEL 324
Score = 67.4 bits (163), Expect = 3e-11
Identities = 49/198 (24%), Positives = 107/198 (54%), Gaps = 4/198 (2%)
Query: 321 QRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQ 380
Q++++L+++Q +Q+E +Q ++L + Q + + ++++ + + E+++ +LQ Q
Sbjct: 218 QQQEQLQQQQFQQQQEQLQQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQ 277
Query: 381 VELQARFSTELEREKLIRQQMEEQVAQKSSE---LEQYLQRVRELEDMYLKLQEALEDER 437
+ LQ + + ++++ + QQ +EQ+ Q+ + LE + ELE M + L E E+
Sbjct: 278 LLLQQQEQLQQQQQQQLLQQQQEQLQQQQLQPPPLEPEEEEEVELELMPVDLGSEQELEQ 337
Query: 438 QARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQ 497
Q RQ+ E ++L+ + + + + + E LEQQ Q + E+QE++ + E Q
Sbjct: 338 Q-RQELERQQELERQQEQRQLQLKLQEELQQLEQQLEQQQQQLEQQEVQLELTPVELGAQ 396
Query: 498 EAMEQLEQLELERKQALE 515
+ QLE ++ + LE
Sbjct: 397 QQEVQLELTPVQPELQLE 414
Score = 49.7 bits (117), Expect = 8e-06
Identities = 47/221 (21%), Positives = 109/221 (49%), Gaps = 18/221 (8%)
Query: 339 RQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTELEREKLIR 398
++ +E Q N S Q+ + E A EE + Q +++LQ +LE++ +
Sbjct: 52 QEEEEPQERNSSPQRPAVSAPVGASEIA-----EETRPGQRELQLQ-----QLEQQPEPQ 101
Query: 399 QQME-EQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEE 457
QQ + EQ+ Q LE Q ++ + +LQ+ ++ Q+ +E +LQ +++
Sbjct: 102 QQPQHEQLQQPQPHLELQQQPQQDGQQQLSQLQQ---EKHQSVHHQELKPELQLMHQQQQ 158
Query: 458 SSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQALEQY 517
+ E+ L+QQQ + + Q+ + Q+VL++Q + Q +QL ++++ L+Q
Sbjct: 159 LQPQQVQEQQRLQQQQE----QLQTQQAQEQQVLQQQEQLQQQVQEQQLLQQQQEQLQQQ 214
Query: 518 EEVKKKLEMATNKTKSWKDKVAHHEGLIRLIEPGSKNPHLI 558
+ ++++ ++ + + ++++ + L+ L + G L+
Sbjct: 215 QLLQQQEQLQQQQFQQQQEQLQQQQQLLLLQQQGQLQQQLL 255
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 79.3 bits (194), Expect = 9e-15
Identities = 51/215 (23%), Positives = 124/215 (57%), Gaps = 6/215 (2%)
Query: 317 KEARQRRKEL--RKKQLAEQEELERQMKELQAANESKQQELEAVR--KKLEEAASRAAEE 372
+E RQ ++E+ +++++ EQEE+ RQ +++ + ++QE + R +K+ + + E+
Sbjct: 455 EEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQ 514
Query: 373 EKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEA 432
E+K + + +++ + E+E+ IR+Q EE + ++ ++ + ++++E E M + ++
Sbjct: 515 EEKMWRQEEKIREQEEKIREQEEKIREQ-EEMMQEQEEKMGEQEEKMQEQEKMRRQEEKI 573
Query: 433 LEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLK 492
E E + R+ +E +R+ + ++ E+E R E E+ EQ++ + E + E E + +
Sbjct: 574 REQEEKIREQKEKIREQEEKIWEQEEKIR-EQEEMMQEQEEKMWEQEEKMCEQEEKMQEQ 632
Query: 493 EQALQEAMEQLEQLELERKQALEQYEEVKKKLEMA 527
E+ ++ E++ + E+ +Q E+ +E ++ LE A
Sbjct: 633 EEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEAA 667
Score = 77.4 bits (189), Expect = 3e-14
Identities = 53/233 (22%), Positives = 127/233 (54%), Gaps = 21/233 (9%)
Query: 317 KEARQRRKELRKKQLAEQEELERQMKELQAANESKQQEL----EAVRKKLEEAASRAAEE 372
+E ++ +E KK ++E++ Q K + +Q+E+ E +R++ E +
Sbjct: 426 REQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMH 485
Query: 373 EKKRLQTQVELQARFSTEL-EREKLIRQQ------MEEQVAQKSSELEQYLQRVRELEDM 425
E+++++ Q E R ++ ++E+ IR+Q EE++ ++ ++ + +++RE E+M
Sbjct: 486 EQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEM 545
Query: 426 YLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQEL 485
+ +E + ++ + Q++E +R+ + ++ E+E R + EK EQ++ I E E++
Sbjct: 546 MQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIR-EQEEKI--WEQEEKIR 602
Query: 486 ENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSWKDKV 538
E + +++EQ +E M + E+ E+++ +++ EE +M + K W+ +V
Sbjct: 603 EQEEMMQEQ--EEKMWEQEEKMCEQEEKMQEQEE-----KMRRQEEKMWEQEV 648
Score = 74.7 bits (182), Expect = 2e-13
Identities = 71/338 (21%), Positives = 153/338 (45%), Gaps = 69/338 (20%)
Query: 291 KKKKQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRKKQ--LAEQEELERQMKELQAAN 348
++K QEW + I ++ ++ R++ +++R+++ + E+EE R+ +E+
Sbjct: 306 EEKIQEWEEKIQEQEEKIR----EQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEK 361
Query: 349 ESKQQELEAV-----------------RKKLEEAASRAAEEEK-----KRLQTQVELQAR 386
E K + LE + ++K+ E + EEEK KR + + ++ +
Sbjct: 362 EEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQ 421
Query: 387 FSTELEREKLIRQQ-----------------MEEQVAQKSSELEQYLQRVRELEDMYLKL 429
E+E+ IR+Q EE+ Q+ E+ + +++RE E+++ +
Sbjct: 422 EEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQK 481
Query: 430 QEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWH-----LEQQQAIQTTEAEKQE 484
++ E E+ +Q+E+ R+ + +EE + E + W EQ++ I+ E + +E
Sbjct: 482 EKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIRE 541
Query: 485 LENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSWKDKVAHHEGL 544
E +E+ + E E++++ E R+Q E+ E ++K+ K + ++K+ E
Sbjct: 542 QEEMMQEQEEKMGEQEEKMQEQEKMRRQE-EKIREQEEKIREQKEKIREQEEKIWEQEEK 600
Query: 545 IRLIEPGSKNPHLITNWGPAAFTEAELEEREKNWKEKK 582
IR E E E+ EK W++++
Sbjct: 601 IREQE------------------EMMQEQEEKMWEQEE 620
Score = 68.2 bits (165), Expect = 2e-11
Identities = 77/324 (23%), Positives = 154/324 (47%), Gaps = 55/324 (16%)
Query: 288 ASDKKKKQEWIQAIHSTIHLLKLG---SPPPHKEARQRRKELRKK-QLAEQEELERQM-- 341
A+ KKK +I+ + L L + +E +++ +L++K QL E E+ E Q+
Sbjct: 185 ATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNV 244
Query: 342 ----------------KELQAANESKQQELEAVRKKLE------EAASRAAEEEKKRLQT 379
++LQA + +EL++V KL+ E +R +++++++
Sbjct: 245 KELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWR 304
Query: 380 QVELQARFSTEL-EREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQ 438
Q E + ++ E+E+ IR+Q E K E E+ ++R E+ M+ K ++ E
Sbjct: 305 QEEKIQEWEEKIQEQEEKIREQEE-----KIREQEEKMRRQEEM--MWEKEEKMRRQEEM 357
Query: 439 ARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQE 498
+ EE +R+L+ + E+E R EK H +Q+ I+ E ++QE E ++EQ ++
Sbjct: 358 MWEKEEKMRRLEEMMWEKEEKIRELEEKMH--EQEKIREQEEKRQEEEK---IREQ--EK 410
Query: 499 AMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSWKDKVAHHEGLIRLIEPGSKNPHLI 558
EQ ++ + ++ EQ E+++++ + K W+ + HE I K
Sbjct: 411 RQEQEAKMWRQEEKIREQEEKIREQ------EKKMWRQEEKIHEQ--EKIREEEKRQEQE 462
Query: 559 TNWGPAAFTEAELEEREKNWKEKK 582
W E ++ E+E+ W++K+
Sbjct: 463 EMWR----QEEKIREQEEIWRQKE 482
Score = 68.2 bits (165), Expect = 2e-11
Identities = 57/264 (21%), Positives = 131/264 (49%), Gaps = 16/264 (6%)
Query: 293 KKQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRKKQL-AEQEELERQMKELQAANESK 351
K QE +Q + S ++L ++ + + L ++QL AE + L ++++ + A +++
Sbjct: 225 KLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQ 284
Query: 352 QQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSE 411
+E E + ++ + +E+K + + ++Q + E+E+ IR+Q E+ Q+
Sbjct: 285 VEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMM 344
Query: 412 LEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARL-----LEEESSKRAELEK 466
E+ + R+ E M+ K ++ E + EE +R+L+ ++ + E+ KR E EK
Sbjct: 345 WEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEK 404
Query: 467 WHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQL--------EQLELERKQALEQYE 518
+ +Q+ Q EA+ E + +E+ ++E +++ EQ ++ ++ ++ E
Sbjct: 405 --IREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQE 462
Query: 519 EVKKKLEMATNKTKSWKDKVAHHE 542
E+ ++ E + + W+ K HE
Sbjct: 463 EMWRQEEKIREQEEIWRQKEKMHE 486
Score = 65.5 bits (158), Expect = 1e-10
Identities = 47/193 (24%), Positives = 104/193 (53%), Gaps = 16/193 (8%)
Query: 316 HKEARQRRKELR----KKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAE 371
H++ + R++E + ++++ +QEE R+ +E E K +E E +K+ E + E
Sbjct: 485 HEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQE---EKIREQEEKIRE 541
Query: 372 EEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQE 431
+E+ + + ++ + E+EK+ RQ EE++ ++ ++ + +++RE E ++
Sbjct: 542 QEEMMQEQEEKMGEQEEKMQEQEKMRRQ--EEKIREQEEKIREQKEKIREQE------EK 593
Query: 432 ALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVL 491
E E + R+ EE +++ + ++ E+E K E E+ EQ++ ++ E + E E +
Sbjct: 594 IWEQEEKIREQEEMMQEQEEKMWEQE-EKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQ 652
Query: 492 KEQALQEAMEQLE 504
+E+ +QE E LE
Sbjct: 653 QEEKMQEHQEHLE 665
Score = 64.7 bits (156), Expect = 2e-10
Identities = 66/299 (22%), Positives = 149/299 (49%), Gaps = 28/299 (9%)
Query: 263 ESLPDKDGK--KCLFLVKCFDKTFEISASDKKKK---------QEWIQAIHSTIHLLK-L 310
E L +K+ K + L LV+ +++ + K+K Q+ +QA HL K L
Sbjct: 217 EELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQA--EADHLGKEL 274
Query: 311 GSPPPHKEARQRRKELRKKQLAEQEE-LERQMKELQAANESKQQELEAVRKKLEEAASRA 369
S +A+ EL + +QEE + RQ +++Q E Q++ E +R++ E+
Sbjct: 275 QSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKI---- 330
Query: 370 AEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMY--- 426
E++++++ Q E+ ++ R++ + + EE++ + + + +++RELE+
Sbjct: 331 -REQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQ 389
Query: 427 ---LKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQ 483
+ +E ++E + R+ E+ ++ +A++ +E R + EK EQ++ + E +
Sbjct: 390 EKIREQEEKRQEEEKIREQEKR-QEQEAKMWRQEEKIREQEEKIR-EQEKKMWRQEEKIH 447
Query: 484 ELENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSWKDKVAHHE 542
E E R +++ QE M + E+ E+++ Q E++ ++ ++ + K W+ + H+
Sbjct: 448 EQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHD 506
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 79.0 bits (193), Expect = 1e-14
Identities = 62/255 (24%), Positives = 127/255 (49%), Gaps = 9/255 (3%)
Query: 286 ISASDKKKKQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQEELERQMKELQ 345
++ S+K + Q ++ + + K P Q ++++L EQE+ R+ +E
Sbjct: 236 LAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKM 295
Query: 346 AANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQV 405
E + +E E ++ EE R ++KRL+ Q + EL +K +R+Q EEQ+
Sbjct: 296 WRQEERLREQEGKMREQEEKMWR----QEKRLREQEKELREQEKELREQKELREQ-EEQM 350
Query: 406 AQKSSELEQYLQRVRELEDMYLKLQEAL-EDERQARQDEETVRKLQARLLEEESSKRAEL 464
++ ++ + +++RE E+ + +E L E E+Q R+ E+ +R + R+ E++ R +
Sbjct: 351 QEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKE 410
Query: 465 EKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVKKKL 524
E+ EQ++ + E ++E + Q K+ QE Q E+ ER++ + + EE ++
Sbjct: 411 ERMR-EQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQ 469
Query: 525 E--MATNKTKSWKDK 537
E M + W+ +
Sbjct: 470 EEKMQKQEENMWEQE 484
Score = 75.1 bits (183), Expect = 2e-13
Identities = 55/239 (23%), Positives = 125/239 (52%), Gaps = 10/239 (4%)
Query: 317 KEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKR 376
+E + R +E +++ + E E M+E + + ++++++ +K+ E + E+E+K
Sbjct: 581 QEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKM 640
Query: 377 LQTQVELQARFSTELEREKLIRQQ---MEEQVAQKSSELEQYLQRVRELEDMYLKLQEAL 433
+ + ++ + E+++L Q+ E + Q+ ++++ +++ E E M K QE
Sbjct: 641 WEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQE 700
Query: 434 ED--ERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVL 491
+ +++ ++EE++R+ + ++ EEE R + EK EQ++ +Q E E E E +
Sbjct: 701 KKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQ-EQEEKMQEQEEEMWEQEEKMWE 759
Query: 492 KEQAL---QEAMEQLEQL-ELERKQALEQYEEVKKKLEMATNKTKSWKDKVAHHEGLIR 546
+E+ + Q EQ E+L E E+ Q E+ E ++K+ K + ++K+ E +R
Sbjct: 760 QEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMR 818
Score = 71.2 bits (173), Expect = 2e-12
Identities = 68/307 (22%), Positives = 146/307 (47%), Gaps = 42/307 (13%)
Query: 317 KEARQRRKELRKKQLAEQEELERQMKELQAAN---ESKQQELEAVR---KKLEEAASRAA 370
KE R R +E +Q+ + E E++M+E + E K QE E +R KK+ E
Sbjct: 409 KEERMREQEKMWEQVEKMRE-EKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMR 467
Query: 371 EEEKKRLQTQVELQARFSTELEREKLIRQQ----MEEQVAQKSSELEQYLQRVRELEDMY 426
E+E+K + + + + E ++++L Q+ +E++ ++ ++ + +++R+ E+M+
Sbjct: 468 EQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMW 527
Query: 427 ------LKLQEALEDERQARQDEETVRKLQARLLEEE---SSKRAELEKWHLEQQQAI-- 475
+ ++ E E Q + EE +R + ++ ++E K E EK +Q++ +
Sbjct: 528 GQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMRE 587
Query: 476 --QTTEAEKQELENQRVLKEQ--ALQEAMEQLEQLELERKQALEQYEEVKKKL-----EM 526
+ E EK+ E + +++EQ +QE E++++ E + + E+ +E ++K+ +M
Sbjct: 588 EERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKM 647
Query: 527 ATNKTKSW--------KDKVAHHEGLIRLIEPGSKNPHLITNWGPAAFTEAELEEREKNW 578
+ K W K+K+ HE ++ E W + E+ +K W
Sbjct: 648 WEQEEKMWEQQRLPEQKEKLWEHE---KMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTW 704
Query: 579 KEKKTTE 585
++K E
Sbjct: 705 DQEKMRE 711
Score = 70.9 bits (172), Expect = 3e-12
Identities = 71/313 (22%), Positives = 147/313 (46%), Gaps = 55/313 (17%)
Query: 317 KEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEK-- 374
+E R++ K++RK++ + ER ++E + +++++ K+L E E+EK
Sbjct: 279 EELREQEKKIRKQEEKMWRQEER-LREQEGKMREQEEKMWRQEKRLREQEKELREQEKEL 337
Query: 375 ---KRLQTQVELQARFSTEL----------------------EREKLIRQQ------MEE 403
K L+ Q E ++ E+EK +R+Q EE
Sbjct: 338 REQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEE 397
Query: 404 QVAQKSSELEQYLQRVRELEDMYLKLQEALE------------DERQARQDEETVRKLQA 451
++ ++ L + +R+RE E M+ ++++ E D+ + Q+EE +R+ +
Sbjct: 398 RMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREK 457
Query: 452 RLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERK 511
++ EEE + R + EK Q+Q E E++E + QR L EQ +E + + E+++ + +
Sbjct: 458 KMREEEETMREQEEKM---QKQEENMWEQEEKEWQQQR-LPEQ--KEKLWEQEKMQEQEE 511
Query: 512 QALEQYEEVKKKLEMATNKTKSWK-DKVAHHEGLIRLIEPGSKNPHLITNWGPAAFTEAE 570
+ EQ E+++ + EM + K W+ +K+ E + E ++ W E +
Sbjct: 512 KIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQ-KMWDQEERMEKK 570
Query: 571 LEERE-KNWKEKK 582
+E+E K W +++
Sbjct: 571 TQEQEKKTWDQEE 583
Score = 68.9 bits (167), Expect = 1e-11
Identities = 67/306 (21%), Positives = 147/306 (48%), Gaps = 38/306 (12%)
Query: 316 HKEARQRRKELRKKQLA----------EQEELERQMKELQAA---NESKQQELEA----V 358
HK+A + +EL K++ A EEL+++ ELQ ES++ E++ +
Sbjct: 192 HKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKEL 251
Query: 359 RKKLEEAASRAAEEEKKRLQTQVELQARFSTELER------EKLIRQ-----QMEEQVAQ 407
++KLE A + + LQ ++ Q E E+ EK+ RQ + E ++ +
Sbjct: 252 KRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMRE 311
Query: 408 KSSELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEK- 466
+ ++ + +R+RE E + ++ L ++++ R+ EE +++ + ++ E+E R + EK
Sbjct: 312 QEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKM 371
Query: 467 WHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQALEQYEEV-----K 521
W Q++ + E + +E E + +E+ + E E+L + E ++ + +E+V +
Sbjct: 372 W--RQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREE 429
Query: 522 KKLEMATNKTKSWKDKVAHHEGLIRLIEPGSKNPHLITNWGPAAFTEAE--LEEREKNWK 579
KK++ KT+ ++K+ E + + + + + E E+ EK W+
Sbjct: 430 KKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQ 489
Query: 580 EKKTTE 585
+++ E
Sbjct: 490 QQRLPE 495
Score = 68.2 bits (165), Expect = 2e-11
Identities = 63/281 (22%), Positives = 143/281 (50%), Gaps = 34/281 (12%)
Query: 321 QRRKELRKKQLAEQEELERQMKELQAANESKQ-QELEAVRKKLEEAASRAAEEEKKRLQT 379
Q +K R++++ EQE+ + +E E K + E + KK +E + ++E+K ++
Sbjct: 529 QEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEK-MRE 587
Query: 380 QVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQA 439
+ ++ R E E+++R+Q EE++ ++ ++++ +++ E E+ + +E + ++ +
Sbjct: 588 EERMREREKKMREEEEMMREQ-EEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEK 646
Query: 440 RQDEETVRKLQARLLEE-----ESSKRAELEKWHLEQQQAI--------QTTEAEKQELE 486
++E Q RL E+ E K E EK EQ++ I +T E EK+ +
Sbjct: 647 MWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQ-EQEEKIWEQEKMEKKTQEQEKKTWD 705
Query: 487 NQRVLKEQALQEAMEQL-EQLELERKQALEQYEEVKK----KLEMATNKTKSWKDKVAHH 541
+++ +E++++E +++ E+ E+ R+Q + E+ +K + EM + K W+ +
Sbjct: 706 QEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMW 765
Query: 542 EGLIRLIEPGSKNPHLITNWGPAAFTEAELEEREKNWKEKK 582
E RL E K + +++E+EK W++++
Sbjct: 766 EQQ-RLPEQKEK-----------LWEHEKMQEQEKIWEQEE 794
Score = 65.1 bits (157), Expect = 2e-10
Identities = 65/304 (21%), Positives = 140/304 (46%), Gaps = 47/304 (15%)
Query: 321 QRRKELRKKQ---------LAEQEELERQMKELQAANESKQQELEAVR--KKLEEAASRA 369
++ K++R+++ + EQ+E R+ +E E +++E +R KK++E +
Sbjct: 380 EQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKT 439
Query: 370 AEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQ------------YLQ 417
++E+K +Q + ++ R E E+ +R+Q E+ Q+ + EQ +
Sbjct: 440 RDQEEK-MQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKE 498
Query: 418 RVRELEDMYLKLQEALEDERQARQDE------------ETVRKLQARLLEEESSKRAELE 465
++ E E M + ++ E E + R E E +R+ + ++ E+E R + +
Sbjct: 499 KLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQ 558
Query: 466 K-WHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVKKKL 524
K W E++ +T E EK+ + + ++E +E M + E+ E ++ + + EE ++
Sbjct: 559 KMWDQEERMEKKTQEQEKKTWDQEEKMRE---EERMREREKKMREEEEMMREQEEKMQEQ 615
Query: 525 E--MATNKTKSWKDKVAHHEGLIRLIEPGSKNPHLITNWGPAAFTEAEL-EEREKNWKEK 581
E M + K W+ + E ++ E K + + + L E++EK W+ +
Sbjct: 616 EEKMQEQEEKMWEQEEKMQEQEEKMWEQEEK----MWEQEEKMWEQQRLPEQKEKLWEHE 671
Query: 582 KTTE 585
K E
Sbjct: 672 KMQE 675
Score = 65.1 bits (157), Expect = 2e-10
Identities = 61/291 (20%), Positives = 144/291 (49%), Gaps = 30/291 (10%)
Query: 320 RQRRKELRKKQ--LAEQEELERQMKELQAANES--KQQELEAVRKKLEEAASRAAEEEK- 374
R++ ++++K++ + EQEE E Q + L E +Q++++ +K+ E + ++E+
Sbjct: 467 REQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEM 526
Query: 375 ----KRLQTQVELQARFSTELEREKLIRQQ------MEEQVAQKSSELEQYL----QRVR 420
K++ Q +++ + E+E+ +R Q EE++ +K+ E E+ +++R
Sbjct: 527 WGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMR 586
Query: 421 ELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESS------KRAELEKWHLEQQQA 474
E E M + ++ E+E R+ EE +++ + ++ E+E K E E+ EQ++
Sbjct: 587 EEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEE- 645
Query: 475 IQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSW 534
+ E E++ E QR+ +++ E++++ E ++Q + +E+ K + + + K+W
Sbjct: 646 -KMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTW 704
Query: 535 KDKVAHHEGLIRLIEPGSKNPHLITNWGPAAFTEAE---LEEREKNWKEKK 582
+ E +R E + + E E E+ E+ W++++
Sbjct: 705 DQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEE 755
Score = 57.0 bits (136), Expect = 5e-08
Identities = 52/237 (21%), Positives = 118/237 (49%), Gaps = 26/237 (10%)
Query: 321 QRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQ 380
Q+R +K++L E E+++ Q K + E K E E + KK +E + ++EK R +
Sbjct: 657 QQRLPEQKEKLWEHEKMQEQEKMQE--QEEKIWEQEKMEKKTQEQEKKTWDQEKMREEES 714
Query: 381 VELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQAR 440
+ EREK +R++ EE + ++ ++++ ++++E E+ + +E + ++ +
Sbjct: 715 MR---------EREKKMREE-EEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKM 764
Query: 441 QDEETVRKLQARLLEEESSKRAELEK-WHLEQQQAIQTTEAEKQELENQRVLKEQAL--- 496
+++ + + + +L E E K E EK W E++ Q + QE E R +E+
Sbjct: 765 WEQQRLPEQKEKLWEHE--KMQEQEKIWEQEEKMRDQEEKMRGQE-EKMRGQEEKMRGQE 821
Query: 497 -------QEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSWKDKVAHHEGLIR 546
++ Q E++ + ++ Q E++++K++ K + ++K+ E +R
Sbjct: 822 EKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMR 878
Score = 53.5 bits (127), Expect = 5e-07
Identities = 58/236 (24%), Positives = 112/236 (47%), Gaps = 25/236 (10%)
Query: 321 QRRKELRKKQLAEQEELERQMKEL--QAANESKQQELEAV----RKKLEEAASRAAEEEK 374
Q+ K +++ EQE+++ Q +++ Q E K QE E K EE + R E EK
Sbjct: 663 QKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMR--EREK 720
Query: 375 KRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQ-----YLQRVRELEDM---Y 426
K + + ++ + E+E+ +++Q EE Q+ EQ QR+ E ++ +
Sbjct: 721 KMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEH 780
Query: 427 LKLQE---ALEDERQARQDEETVRKLQARLLEEESSKRAELEK-WHLEQQQAIQTTEAEK 482
K+QE E E + R EE +R + ++ +E R + EK W Q++ + E +
Sbjct: 781 EKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMW--GQEEKMWGQEEKM 838
Query: 483 QELENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSWKDKV 538
E + +E+ ++E M+ E+ E+++ + EE K+ K + ++K+
Sbjct: 839 WGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEE---KMREQEEKMRGQEEKI 891
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 78.6 bits (192), Expect = 2e-14
Identities = 57/228 (25%), Positives = 124/228 (54%), Gaps = 8/228 (3%)
Query: 317 KEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKR 376
+EA+ R+E +++ EQEE R+ +E E K E E +R++ + ++++
Sbjct: 475 QEAKMWRQE---EKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEK 531
Query: 377 LQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEAL-ED 435
++ Q E+ + E+E+ IR+Q EE++ ++ ++ +++RE E+ + +E + E
Sbjct: 532 IREQEEIWRQKEKIHEQEEKIRKQ-EEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQ 590
Query: 436 ERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQA 495
E + R+ EE +R+ Q + +E+ K E E+ EQ++ +Q E + + E + +E+
Sbjct: 591 EEKIREQEEKIRE-QEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKK 649
Query: 496 LQEAMEQL-EQLELERKQALEQYEEVKKKLEMATNKTKSWKDKVAHHE 542
++E E++ EQ E+ ++Q + +E+ +K E K + ++K+ E
Sbjct: 650 IREQEEKIREQEEMMQEQEEKMWEQEEKMCEQ-EEKMQEQEEKMRRQE 696
Score = 75.5 bits (184), Expect = 1e-13
Identities = 62/247 (25%), Positives = 122/247 (49%), Gaps = 21/247 (8%)
Query: 317 KEARQRRKELRKKQLAEQ-EELERQMKELQAANES--KQQELEAVR---KKLEEAASRAA 370
KE + RR+E + E+ ELE +M E + E K+QE E +R K+ E+ A
Sbjct: 422 KEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWR 481
Query: 371 EEEKKRLQTQVELQARFSTELEREKLIRQQM--EEQVAQKSSELEQYLQRVRELEDMYLK 428
+EEK R Q + + + EK+ Q+ EE+ Q+ E+ + +++RE E+++ +
Sbjct: 482 QEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQ 541
Query: 429 LQEALEDERQARQDEETVRKLQARLLEEESSKRAELEK-WHLE------------QQQAI 475
++ E E + R+ EE + + + ++ ++E R + EK W E Q++ I
Sbjct: 542 KEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKI 601
Query: 476 QTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSWK 535
+ E QE E + +E+ + E E++++ E + ++ E+ E +KK+ K + +
Sbjct: 602 REQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQE 661
Query: 536 DKVAHHE 542
+ + E
Sbjct: 662 EMMQEQE 668
Score = 73.6 bits (179), Expect = 5e-13
Identities = 53/227 (23%), Positives = 123/227 (54%), Gaps = 26/227 (11%)
Query: 316 HKEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKK 375
H++ + R +E R+ EQEE+ RQ ++++ +Q+E+ ++K+ E + ++E+K
Sbjct: 508 HEQEKIREEEKRQ----EQEEMWRQEEKIR-----EQEEIWRQKEKIHEQEEKIRKQEEK 558
Query: 376 RLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEAL-- 433
+ + ++ + E+E+ + +Q EE++ ++ ++ + +++RE E+M + +E +
Sbjct: 559 MWRQEEKMHDQEEKIREQEEKVWRQ-EEKIREQEEKIREQEEKIREQEEMTQEQEEKMGE 617
Query: 434 ------EDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELEN 487
E E + ++ EE +R+ + ++ E+E R + EK EQ++ +Q E + E E
Sbjct: 618 QEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIR-EQEEMMQEQEEKMWEQEE 676
Query: 488 QRVLKEQALQEAMEQLE-------QLELERKQALEQYEEVKKKLEMA 527
+ +E+ +QE E++ + E+ +Q E+ +E ++ LE A
Sbjct: 677 KMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEAA 723
Score = 73.2 bits (178), Expect = 6e-13
Identities = 52/259 (20%), Positives = 131/259 (50%), Gaps = 13/259 (5%)
Query: 291 KKKKQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRKKQ--LAEQEELERQMKELQAAN 348
++K QEW + I ++ ++ R++ +++R+++ + E+EE R+ +E+
Sbjct: 367 EEKIQEWEEKIQEQEEKIR----EQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEK 422
Query: 349 ESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQK 408
E K + E + + EE E+ ++ + + + + R E RE+ RQ+ E ++ ++
Sbjct: 423 EEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQ 482
Query: 409 SSELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWH 468
++ + +++RE E+ + +E + ++ + R++E+ R+ Q + +E R + E W
Sbjct: 483 EEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEK--RQEQEEMWRQEEKIREQEEIWR 540
Query: 469 L-----EQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVKKK 523
EQ++ I+ E + E + +E+ ++E E++ + E + ++ E+ E ++K
Sbjct: 541 QKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEK 600
Query: 524 LEMATNKTKSWKDKVAHHE 542
+ T+ ++K+ E
Sbjct: 601 IREQEEMTQEQEEKMGEQE 619
Score = 72.0 bits (175), Expect = 1e-12
Identities = 73/300 (24%), Positives = 155/300 (51%), Gaps = 34/300 (11%)
Query: 263 ESLPDKDGK--KCLFLVKCFDKTFEISASDKKKK---------QEWIQAIHSTIHLLK-L 310
E L +K+ K + L LV+ +++ + K+K Q+ +QA HL K L
Sbjct: 278 EELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQA--EADHLGKEL 335
Query: 311 GSPPPHKEARQRRKELRKKQLAEQEE-LERQMKELQAANESKQQELEAVRK---KLEEAA 366
S +A+ EL + +QEE + RQ +++Q E Q++ E +R+ K+ E
Sbjct: 336 QSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQE 395
Query: 367 SRAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMY 426
+ +E+ + + +++ + E+E+ +R+Q EE + +K +++RELE+
Sbjct: 396 EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQ-EEMMWEKE-------EKIRELEEK- 446
Query: 427 LKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELE 486
+ QE + ++ + RQ+EE +R+ + R +E+ +K E+ EQ++ I+ E EK +
Sbjct: 447 MHEQEKIREQEEKRQEEEKIREQEKR--QEQEAKMWRQEEKIREQEEKIREQE-EKMWRQ 503
Query: 487 NQRVLKEQALQEAMEQLEQLELER-KQALEQYEEV---KKKLEMATNKTKSWKDKVAHHE 542
+++ +++ ++E ++ EQ E+ R ++ + + EE+ K+K+ K + ++K+ E
Sbjct: 504 EEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQE 563
Score = 35.8 bits (81), Expect = 0.11
Identities = 23/108 (21%), Positives = 54/108 (50%), Gaps = 3/108 (2%)
Query: 309 KLGSPPPHKEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASR 368
K+G ++ + + +++++ QEE R+ ++ E K +E E + ++ EE
Sbjct: 614 KMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWE 673
Query: 369 AAE---EEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELE 413
E E+++++Q Q E R ++ +++ +Q EE++ + LE
Sbjct: 674 QEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLE 721
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 78.2 bits (191), Expect = 2e-14
Identities = 51/216 (23%), Positives = 114/216 (52%), Gaps = 8/216 (3%)
Query: 318 EARQRRKELRKK--QLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAE---E 372
+ R++ ++R++ Q+ EQE R+ + E + E E + EE + E E
Sbjct: 165 QVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGE 224
Query: 373 EKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEA 432
++++++ Q E ++++++ Q+ EEQ+ ++ ++ + +++RE E+ LK +E
Sbjct: 225 QEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQ 284
Query: 433 LEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLK 492
E E Q + EE +R+ + ++ E+E R + E+ +++Q + E ++ E K
Sbjct: 285 TEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQK 344
Query: 493 EQAL---QEAMEQLEQLELERKQALEQYEEVKKKLE 525
EQ ++ EQ EQ++ + +Q +Q E+++K+ E
Sbjct: 345 EQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEE 380
Score = 73.2 bits (178), Expect = 6e-13
Identities = 51/202 (25%), Positives = 103/202 (50%), Gaps = 5/202 (2%)
Query: 317 KEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKR 376
+E Q+++E +KQ + + E QM+E Q +Q+E +K+ E + E+E++
Sbjct: 240 EEQVQKQEEQVQKQEEQMRKQEEQMRE-QEEQMREQEEQMLKQKEQTEQEEQTGEQEEQM 298
Query: 377 LQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDE 436
+ + +++ + E+E+ +R+Q E+ Q+ EQ Q + E M+ + ++ E E
Sbjct: 299 REQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQE 358
Query: 437 RQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQAL 496
Q ++ EE VRK + ++ ++E R + E+ +++Q + E ++ E R +EQ
Sbjct: 359 EQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQ-- 416
Query: 497 QEAMEQLEQLELERKQALEQYE 518
EQ EQ+ + + EQ E
Sbjct: 417 --MGEQKEQMRKQEEHMGEQKE 436
Score = 72.4 bits (176), Expect = 1e-12
Identities = 57/242 (23%), Positives = 120/242 (49%), Gaps = 21/242 (8%)
Query: 309 KLGSPPPHKEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASR 368
++G ++ + + +++Q+ EQEE R+ +E E + Q+ E +K EE +
Sbjct: 200 QMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRK 259
Query: 369 AAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLK 428
+EE+ R Q E Q R E ++ + + EEQ ++ ++ + +++RE E
Sbjct: 260 --QEEQMREQ---EEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQE----- 309
Query: 429 LQEALEDERQARQDEETVRKLQARLLEEESSKRAELEK-WHLEQQQAIQTTEAEKQE--- 484
++ E E Q R+ EE + K + ++ E++ + E+ W E+Q Q + +KQE
Sbjct: 310 -EQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQV 368
Query: 485 --LENQRVLKEQALQEAMEQL----EQLELERKQALEQYEEVKKKLEMATNKTKSWKDKV 538
E Q +E+ +++ EQ+ EQ+ +++Q EQ E+++++ E + + + +
Sbjct: 369 RKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQE 428
Query: 539 AH 540
H
Sbjct: 429 EH 430
Score = 72.0 bits (175), Expect = 1e-12
Identities = 54/234 (23%), Positives = 126/234 (53%), Gaps = 17/234 (7%)
Query: 318 EARQRRKELRKK--QLAEQE----ELERQMKELQAANESKQQELEAVRKKLEEAASRAAE 371
+ R++ ++R++ Q+ EQE E E Q++E + ++ ++ ++ E + E
Sbjct: 144 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGE 203
Query: 372 EEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQE 431
+E++ + + ++Q + E+E+ +R+Q EEQ+ ++ ++++ ++V++ E+ K +E
Sbjct: 204 QEEQMGEQEEQMQKQEEQMGEQEEQMRKQ-EEQMGEQEEQVQKQEEQVQKQEEQMRKQEE 262
Query: 432 AL-EDERQARQDEETVRKLQARLLEEESS-----KRAELEKWHLEQQQAIQTTEAEKQEL 485
+ E E Q R+ EE + K + + +EE + + E E+ EQ++ ++ E + +E
Sbjct: 263 QMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQ 322
Query: 486 ENQRVLKEQALQEAMEQL----EQLELERKQALEQYEEVKKKLEMATNKTKSWK 535
E Q +E+ + E EQ+ EQ+ + +Q EQ E+++K+ E + + +
Sbjct: 323 EEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMR 376
Score = 71.6 bits (174), Expect = 2e-12
Identities = 54/227 (23%), Positives = 119/227 (52%), Gaps = 12/227 (5%)
Query: 318 EARQRRKELRKK--QLAEQE----ELERQMKELQAANESKQQELEAVRKKLEEAASRAAE 371
+ R++ ++R++ Q+ EQE E E Q++E + ++ ++ ++ E + E
Sbjct: 123 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE 182
Query: 372 EEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQE 431
+E + + + ++ + E+E+ + +Q E+ Q+ EQ Q ++ E M + ++
Sbjct: 183 QEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQ 242
Query: 432 ALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVL 491
+ E Q ++ EE +RK + ++ E+E R + E+ +++Q TE E+Q E + +
Sbjct: 243 VQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQ----TEQEEQTGEQEEQM 298
Query: 492 KEQALQEAMEQLEQLELERKQALEQYEEV-KKKLEMATNKTKSWKDK 537
+EQ ++ EQ EQ+ + +Q EQ E++ K++ +M K + W+ K
Sbjct: 299 REQE-EQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQK 344
Score = 71.2 bits (173), Expect = 2e-12
Identities = 54/238 (22%), Positives = 127/238 (53%), Gaps = 20/238 (8%)
Query: 318 EARQRRKELRKK--QLAEQE----ELERQMKELQAANESKQQELEAVRKKLEEAASRAAE 371
+ R++ ++R++ Q+ EQE E E Q++E + ++ ++ ++ E + E
Sbjct: 116 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE 175
Query: 372 EEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQE 431
+E + + + +++ + E+E + +Q EEQ+ ++ ++++ +++ E E+ K +E
Sbjct: 176 QEGQVREQEGQVREQEGQMGEQEGQMGEQ-EEQMGEQEEQMQKQEEQMGEQEEQMRKQEE 234
Query: 432 AL-EDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAI----------QTTEA 480
+ E E Q ++ EE V+K + ++ ++E R + E+ +++Q + QT E
Sbjct: 235 QMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQ 294
Query: 481 EKQELENQRVLKEQALQEAMEQLEQLELERKQALEQYEEV-KKKLEMATNKTKSWKDK 537
E+Q E + ++EQ ++ EQ EQ+ + +Q +Q E++ ++K +M K + WK +
Sbjct: 295 EEQMREQEEQMREQE-EQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQE 351
Score = 69.3 bits (168), Expect = 9e-12
Identities = 50/219 (22%), Positives = 119/219 (54%), Gaps = 14/219 (6%)
Query: 318 EARQRRKELRKK--QLAEQE----ELERQMKELQAANESKQQELEAVRKKLEEAASRAAE 371
+ R++ ++R++ Q+ EQE E E QM E + + +++++ +++ + + E
Sbjct: 179 QVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGE 238
Query: 372 EEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQE 431
+E++ + + ++Q + ++E+ +R+Q EEQ+ ++ ++ + ++ + E + ++
Sbjct: 239 QEEQVQKQEEQVQKQEEQMRKQEEQMREQ-EEQMREQEEQMLKQKEQTEQEEQTGEQEEQ 297
Query: 432 ALEDERQARQDEETVRKLQARLLE-EESSKRAELEKWHLEQQQAIQTTEAEKQELENQRV 490
E E Q R+ EE +R+ + ++ E EE + E + W ++Q Q + KQ E Q
Sbjct: 298 MREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQ--EEQMG 355
Query: 491 LKEQALQEAMEQL----EQLELERKQALEQYEEVKKKLE 525
+E+ +Q+ EQ+ EQ+ + +Q +Q E+++K+ E
Sbjct: 356 EQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEE 394
Score = 67.8 bits (164), Expect = 3e-11
Identities = 59/276 (21%), Positives = 137/276 (49%), Gaps = 15/276 (5%)
Query: 314 PPHKEARQRRKELRKK--QLAEQE----ELERQMKELQAANESKQQELEAVRKKLEEAAS 367
P + R++ ++R++ Q+ EQE E E Q++E + ++ ++ ++ E
Sbjct: 49 PQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 108
Query: 368 RAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYL 427
+ E+E + + + +++ + E+E +R+Q E QV ++ ++ + +VRE E
Sbjct: 109 QVREQEGQVREQEGQVREQEGQVREQEGQVREQ-EGQVREQEGQVREQEGQVREQEGQVR 167
Query: 428 KLQ-EALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELE 486
+ + + E E Q R+ E VR+ + ++ E+E + E E+ EQ++ +Q E + E E
Sbjct: 168 EQEGQVREQEGQVREQEGQVREQEGQMGEQEG-QMGEQEEQMGEQEEQMQKQEEQMGEQE 226
Query: 487 NQRVLKEQALQEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSWKDKVAHHEGLIR 546
Q +E+ + EQ EQ++ + +Q +Q E+++K+ E + + +++ E +++
Sbjct: 227 EQMRKQEEQMG---EQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQ---EEQMLK 280
Query: 547 LIEPGSKNPHLITNWGPAAFTEAELEEREKNWKEKK 582
E + E ++ E+E+ +E++
Sbjct: 281 QKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQE 316
Score = 49.7 bits (117), Expect = 8e-06
Identities = 39/190 (20%), Positives = 93/190 (48%), Gaps = 11/190 (5%)
Query: 285 EISASDKKKKQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQEELERQMKEL 344
++ +++ +++ Q +LK +E ++E ++Q + E E QM+E
Sbjct: 256 QMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMRE- 314
Query: 345 QAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQ 404
E + +E E K EE E+K+++ Q E + ++ ++ Q+ EEQ
Sbjct: 315 ---QEEQMREQEEQMGKQEE----QMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQ 367
Query: 405 VAQKSSELEQYLQRVRELEDMYLKLQEAL-EDERQARQDEETVRKLQARLLEEESSKRAE 463
V ++ ++ + +++R+ E+ K +E + E + Q + +E +R+ + ++ E++ R +
Sbjct: 368 VRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQ 427
Query: 464 LEKWHLEQQQ 473
E H+ +Q+
Sbjct: 428 EE--HMGEQK 435
Score = 46.6 bits (109), Expect = 6e-05
Identities = 44/191 (23%), Positives = 89/191 (46%), Gaps = 17/191 (8%)
Query: 403 EQVAQKSSELEQYLQRVR-ELEDMYLKLQEA----------LEDERQARQDEETVRKLQA 451
E++ +K++EL++ LQ V E ++ L ++E L E Q R+ E VR+ +
Sbjct: 7 EELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVREQEG 66
Query: 452 RLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERK 511
++ E+E R E E EQ+ ++ E + +E E Q +E ++E Q+ + E + +
Sbjct: 67 QVREQEGQVR-EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVR 125
Query: 512 QALEQYEEVKKKLEMATNKTKSWKDKVAHHEGLIRLIEPGSKNPHLITNWGPAAFTEAEL 571
+ Q E + ++ + + + +V EG +R E + G E ++
Sbjct: 126 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQE-----GQVREQEGQV 180
Query: 572 EEREKNWKEKK 582
E+E +E++
Sbjct: 181 REQEGQVREQE 191
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 77.4 bits (189), Expect = 3e-14
Identities = 65/230 (28%), Positives = 116/230 (50%), Gaps = 16/230 (6%)
Query: 317 KEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKR 376
K+A + ++L + +LA QE++ ++ L+ + + E +R+ + E E EK++
Sbjct: 2408 KQAEEIGEKLHRTELATQEKVTL-VQTLEIQRQQSDHDAERLREAIAEL-----EREKEK 2461
Query: 377 LQTQVELQARFSTELEREKLIRQQMEEQVAQKS--SELEQYLQRVRELEDMYLKLQEALE 434
LQ + +L S E++ + + E Q Q+S SE + LQR R +E KL++ +
Sbjct: 2462 LQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQ 2521
Query: 435 DE-RQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQA---IQTTEAEKQELENQRV 490
DE +A+Q E ++ Q ++ +E A +E+ Q +A ++ + E Q+LE QR
Sbjct: 2522 DEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRR 2581
Query: 491 LKEQAL----QEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSWKD 536
+E+ L Q EQL+ LE + + AL EEV AT + +D
Sbjct: 2582 QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRD 2631
Score = 73.6 bits (179), Expect = 5e-13
Identities = 66/236 (27%), Positives = 113/236 (47%), Gaps = 31/236 (13%)
Query: 320 RQRRKELRKKQLAEQEELERQMKELQAANESKQ--QELEAVRKKLEEAASRAAEEEKKRL 377
RQ + E ++K+ AE E R E +AA E ++ Q LE +R + EEA R + E +R
Sbjct: 1501 RQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1560
Query: 378 Q------------TQVELQARFSTELEREKLIRQQMEEQ---VAQKSSELEQYLQRV--- 419
+ + ELQ++ ++ E+ + + ++E+ VAQ E E+ Q+
Sbjct: 1561 RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1620
Query: 420 --------RELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQ 471
RELE LK EAL QA + + QA +++ E + +
Sbjct: 1621 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1680
Query: 472 QQAIQTTEAEKQELENQRVLKEQALQE---AMEQLEQLELERKQALEQYEEVKKKL 524
+QA++ E +QELE QR L E Q+ A ++L +L E +Q +Q + ++++L
Sbjct: 1681 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1736
Score = 73.2 bits (178), Expect = 6e-13
Identities = 76/285 (26%), Positives = 140/285 (49%), Gaps = 50/285 (17%)
Query: 287 SASDKKKKQEW---IQAIHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQ---EELERQ 340
+A+ +K+QE + + + + +L +E+R ++ +++ AE EL +
Sbjct: 1743 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1802
Query: 341 MKELQA-ANESKQQELEAVRKKLEEAASRAAEEEK------------KRLQTQVELQARF 387
L+A A E+K+Q A E+AA + AE E+ RL+T+ E+ +
Sbjct: 1803 AARLRALAEEAKRQRQLAE----EDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK- 1857
Query: 388 STELEREKL---------IRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDE-- 436
E E E+L R+++EEQ AQ +++E+ L ++R+ D L+ Q+ L ++
Sbjct: 1858 EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTL 1917
Query: 437 RQARQDEETVRKLQARLLEEESSKRAELE----KWHLEQQQAIQTTEAEKQELENQRVL- 491
RQ RQ EE + L+A E+ ++ +AELE + + +++ E + E QR L
Sbjct: 1918 RQRRQVEEEILALKAS-FEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 1976
Query: 492 ---------KEQALQEAMEQLEQLELERKQALEQYEEVKKKLEMA 527
E+ +Q+++ E+ +RK ALE+ E +K K+E A
Sbjct: 1977 AEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2021
Score = 70.9 bits (172), Expect = 3e-12
Identities = 69/264 (26%), Positives = 130/264 (49%), Gaps = 15/264 (5%)
Query: 291 KKKKQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQEELERQMKELQAA--N 348
+++ + W + + L +++ + + ++K+ AE+E R E QA
Sbjct: 1628 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1687
Query: 349 ESKQQELEAVRKKLEEAASR--AAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVA 406
E +QELE R+ E A + AAE+E RL+ + E Q +L E+L R Q E A
Sbjct: 1688 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE-QGEQQRQLLEEELARLQREAAAA 1746
Query: 407 -QKSSELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQA-----RLLEEESSK 460
QK ELE L +VR ++ L + E+E ++ E++ ++L+A R L EE+++
Sbjct: 1747 TQKRQELEAELAKVRAEMEVLLASKARAEEESRS-TSEKSKQRLEAEAGRFRELAEEAAR 1805
Query: 461 RAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQ--ALQEAMEQLEQLELERKQALEQYE 518
L + ++Q+ + +A +Q E +RVL E+ A+ EA + E+ K+ + E
Sbjct: 1806 LRALAE-EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE 1864
Query: 519 EVKKKLEMATNKTKSWKDKVAHHE 542
+++ E + + +++ A H+
Sbjct: 1865 RLRRLAEDEAFQRRRLEEQAAQHK 1888
Score = 70.9 bits (172), Expect = 3e-12
Identities = 61/272 (22%), Positives = 127/272 (46%), Gaps = 30/272 (11%)
Query: 285 EISASDKKKKQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRK-----------KQLAE 333
+++A ++++++E + + ++ + ARQR+ L + ++L E
Sbjct: 1974 QLAAEEERRRREAEERVQKSL-------AAEEEAARQRKAALEEVERLKAKVEEARRLRE 2026
Query: 334 QEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTELER 393
+ E E ++LQ A E+ Q+ L+A K A + +E ++ LQ + + + E E
Sbjct: 2027 RAEQE-SARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA 2085
Query: 394 EKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARL 453
+ ++ EE Q E Q ++V E E +L+++ E++ QAR + + +
Sbjct: 2086 ARRAAEEAEEARVQAEREAAQSRRQVEEAE----RLKQSAEEQAQARAQAQAAAEKLRKE 2141
Query: 454 LEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQA 513
E+E+++RA+ E+ L Q+QA E+E + EQ L++ + ++L R Q
Sbjct: 2142 AEQEAARRAQAEQAALRQKQAADA------EMEKHKKFAEQTLRQKAQVEQELTTLRLQ- 2194
Query: 514 LEQYEEVKKKLEMATNKTKSWKDKVAHHEGLI 545
LE+ + K L+ + K+ + A +
Sbjct: 2195 LEETDHQKNLLDEELQRLKAEATEAARQRSQV 2226
Score = 68.9 bits (167), Expect = 1e-11
Identities = 63/228 (27%), Positives = 114/228 (50%), Gaps = 35/228 (15%)
Query: 320 RQRRKELRKKQLAEQEELERQMKELQAANESKQQ-----------ELEAVRKK------L 362
R R +E ++ QEE ER +++Q ++ K+Q E EA R+K L
Sbjct: 1479 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1538
Query: 363 EEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVREL 422
EE +A E E++ Q +VE + LE + R E ++++S E+ Q R L
Sbjct: 1539 EELRLQAEEAERRLRQAEVERARQVQVALETAQ--RSAEAELQSKRASFAEKTAQLERSL 1596
Query: 423 EDMYLKLQEALED-ERQARQD-------EETVRKLQARLLEEESSKRAELEKWHLEQQQA 474
++ ++ + + E+ ER+A+Q EE R+L+ L+ + R L+ + QQ++
Sbjct: 1597 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS 1656
Query: 475 IQTTEAEKQELENQRVLK------EQALQEAMEQLEQLELERKQALEQ 516
+ EAEKQ+ E +R + EQA+++ +L + ELE+++ L +
Sbjct: 1657 LAQAEAEKQKEEAEREARRRGKAEEQAVRQ--RELAEQELEKQRQLAE 1702
Score = 68.9 bits (167), Expect = 1e-11
Identities = 73/244 (29%), Positives = 118/244 (48%), Gaps = 25/244 (10%)
Query: 308 LKLGSPPPHKEARQRRKE------LRKKQLAEQEELERQMKELQAANESKQQELEAVRKK 361
L+LG + E R KE R++QLA +EE R+ E + +S E EA R++
Sbjct: 1946 LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE-ERVQKSLAAEEEAARQR 2004
Query: 362 ---LEEAAS-RAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQ------VAQKSSE 411
LEE +A EE +RL+ + E ++ +L +E ++ E+ V QK E
Sbjct: 2005 KAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE 2064
Query: 412 LEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQ 471
L+Q LQ+ + + D +L+ E R+A ++ E R +QA E + R ++E+ +
Sbjct: 2065 LQQTLQQEQSVLD---QLRGEAEAARRAAEEAEEAR-VQAE--REAAQSRRQVEEAERLK 2118
Query: 472 QQAIQTTEAEKQELENQRVLKEQALQEAME--QLEQLELERKQALEQYEEVKKKLEMATN 529
Q A + +A Q L+++A QEA Q EQ L +KQA + E KK T
Sbjct: 2119 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2178
Query: 530 KTKS 533
+ K+
Sbjct: 2179 RQKA 2182
Score = 65.9 bits (159), Expect = 1e-10
Identities = 82/296 (27%), Positives = 136/296 (45%), Gaps = 29/296 (9%)
Query: 317 KEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKR 376
+ A+Q+ + R ++ AE+E Q+K +A Q E A +K L +A + +EE +R
Sbjct: 1612 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1671
Query: 377 ---LQTQVELQARFSTELEREKLIRQ-QMEEQVAQKSSELEQYLQRVRELEDMYLKLQEA 432
+ + E QA EL ++L +Q Q+ E AQ+ EQ L R+R + + ++
Sbjct: 1672 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1731
Query: 433 LEDERQARQDEETVRKLQARLLEEESSK-RAELEKWHLEQQQAIQ----TTEAEKQELEN 487
LE+E Q E + + LE E +K RAE+E + +A + T+E KQ LE
Sbjct: 1732 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1791
Query: 488 Q----RVLKEQALQ---EAMEQLEQLELERKQALEQYEEVKKKL-----------EMATN 529
+ R L E+A + A E Q +L + A Q E ++ L + T
Sbjct: 1792 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE 1851
Query: 530 KTKSWKDKVAHHEGLIRLIEPGSKNPHLITNWGPAAFTEAELEEREKNWKEKKTTE 585
+ K+K A +E L RL E + + AA +A++EER ++ +E
Sbjct: 1852 AEIALKEKEAENERLRRLAEDEAFQRRRLEE--QAAQHKADIEERLAQLRKASDSE 1905
Score = 63.5 bits (153), Expect = 5e-10
Identities = 55/211 (26%), Positives = 100/211 (47%), Gaps = 23/211 (10%)
Query: 328 KKQLAEQEELERQMKELQAANES-----KQQELEAVRKKLEEAASRAAEEEKKRLQTQVE 382
+K A + ELE ++ +++ E +Q ELEA R++ AAEEE++R + +
Sbjct: 1935 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR-----QLAAEEERRRREAEER 1989
Query: 383 LQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQD 442
+Q + E EE Q+ + LE+ ++R++ + +L+E E E ARQ
Sbjct: 1990 VQKSLAAE-----------EEAARQRKAALEE-VERLKAKVEEARRLRERAEQE-SARQL 2036
Query: 443 EETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQ 502
+ Q RL EE + +++ E QQ +Q ++ +L + +A +EA E
Sbjct: 2037 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2096
Query: 503 LEQLELERKQALEQYEEVKKKLEMATNKTKS 533
Q E E Q+ Q EE ++ + A + ++
Sbjct: 2097 RVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2127
Score = 62.0 bits (149), Expect = 1e-09
Identities = 54/212 (25%), Positives = 111/212 (52%), Gaps = 16/212 (7%)
Query: 317 KEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEE-EKK 375
+EA Q+R + +K A ++++ +ELQ + +Q L+ +R + E AA RAAEE E+
Sbjct: 2040 QEAAQKRLQAEEK--AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE-AARRAAEEAEEA 2096
Query: 376 RLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALED 435
R+Q + E A+ ++E + ++Q EEQ AQ ++ + +++R+ + E
Sbjct: 2097 RVQAERE-AAQSRRQVEEAERLKQSAEEQ-AQARAQAQAAAEKLRK--------EAEQEA 2146
Query: 436 ERQARQDEETVRKLQARLLEEESSKR--AELEKWHLEQQQAIQTTEAEKQELENQRVLKE 493
R+A+ ++ +R+ QA E E K+ + + + +Q + T + +E ++Q+ L +
Sbjct: 2147 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2206
Query: 494 QALQEAMEQLEQLELERKQALEQYEEVKKKLE 525
+ LQ + + +R Q E+ V+ ++E
Sbjct: 2207 EELQRLKAEATEAARQRSQVEEELFSVRVQME 2238
Score = 62.0 bits (149), Expect = 1e-09
Identities = 61/249 (24%), Positives = 119/249 (47%), Gaps = 43/249 (17%)
Query: 317 KEAR---QRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEE 373
+EAR +R ++Q+ E E L++ +E A Q E +RK+ E+ A+R A+ E
Sbjct: 2094 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2153
Query: 374 KKRLQ------TQVELQARFSTELEREKL--------IRQQMEEQVAQKSSELEQYLQRV 419
+ L+ ++E +F+ + R+K +R Q+EE QK+ L++ LQR+
Sbjct: 2154 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL-LDEELQRL 2212
Query: 420 RELEDMYLKLQEALEDER-QARQDEETVRKLQARL------------------LEEESSK 460
+ + + +E+E R E + KL+AR+ L+EE+ K
Sbjct: 2213 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2272
Query: 461 RA----ELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQA--L 514
E + + Q+A + + +++L QR L E+ L+E M+ +++ + +A L
Sbjct: 2273 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2332
Query: 515 EQYEEVKKK 523
+Q +E+ ++
Sbjct: 2333 QQQKELAQE 2341
Score = 59.7 bits (143), Expect = 7e-09
Identities = 70/267 (26%), Positives = 111/267 (41%), Gaps = 17/267 (6%)
Query: 318 EARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRL 377
+A + KEL+++ E E + Q S Q+EL+ +R+ E AE + K
Sbjct: 1385 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE------AEIQAKAR 1438
Query: 378 QTQVELQARFSTELEREKLIRQQMEEQVAQKSS---ELEQYLQRVRELEDMYLKLQEALE 434
Q + ++R E E +++R Q+E Q+ EL+ R E E + QE E
Sbjct: 1439 QAEAAERSRLRIE-EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1497
Query: 435 DERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQ 494
R+ QD E+ RK QA +E S +AE E E+Q+A+Q E + + E Q
Sbjct: 1498 RLRRQVQD-ESQRKRQAE-VELASRVKAEAEAAR-EKQRALQALEELRLQAEEAERRLRQ 1554
Query: 495 ALQEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSWKDKVAHHEGLIRLIEPGSKN 554
A E Q+ Q+ LE Q + E K+ A + + H + +L E +
Sbjct: 1555 AEVERARQV-QVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1613
Query: 555 PHLITNWGPAAFTEAELEEREKNWKEK 581
A E E + W+ K
Sbjct: 1614 AQ---QQAEAERAREEAERELERWQLK 1637
Score = 59.3 bits (142), Expect = 9e-09
Identities = 49/217 (22%), Positives = 105/217 (48%), Gaps = 19/217 (8%)
Query: 331 LAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTE 390
L EE ER ++ +A + E+EA +K + A A+ + + + ELQ R E
Sbjct: 1341 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1400
Query: 391 LEREKLIRQQMEEQVAQKSSELEQYLQRVRELE--DMYLKLQEALEDERQARQDEETVRK 448
+ R R++ Q+ +++ LQ++R+ ++ K ++A ER + EE +R
Sbjct: 1401 VVR----REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1456
Query: 449 LQARLLEEESSK----------RAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQE 498
++ +L E + RA E+ +++QA + E +++++++ K QA E
Sbjct: 1457 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1516
Query: 499 AMEQLE---QLELERKQALEQYEEVKKKLEMATNKTK 532
+++ + E+++AL+ EE++ + E A + +
Sbjct: 1517 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR 1553
Score = 59.3 bits (142), Expect = 9e-09
Identities = 65/229 (28%), Positives = 123/229 (53%), Gaps = 34/229 (14%)
Query: 319 ARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAA------SRAAEE 372
A +++++L + + + ER+ KELQ ++ + E VR+ EEAA R+ +E
Sbjct: 1368 ALEKQRQLAEAHAQAKAQAEREAKELQ-----QRMQEEVVRR--EEAAVDAQQQKRSIQE 1420
Query: 373 EKKRLQ--TQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVR-----ELEDM 425
E ++L+ ++ E+QA+ + + E + R ++EE++ +LE +R R EL+ +
Sbjct: 1421 ELQQLRQSSEAEIQAK-ARQAEAAERSRLRIEEEIRVVRLQLEA-TERQRGGAEGELQAL 1478
Query: 426 YLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQEL 485
+ +EA +RQA+++ E +R R +++ES ++ + E +E ++ EAE
Sbjct: 1479 RARAEEAEAQKRQAQEEAERLR----RQVQDESQRKRQAE---VELASRVK-AEAEAAR- 1529
Query: 486 ENQRVLKEQALQEAMEQLEQLELERKQA-LEQYEEVKKKLEMATNKTKS 533
E QR L QAL+E Q E+ E +QA +E+ +V+ LE A ++
Sbjct: 1530 EKQRAL--QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1576
Score = 58.5 bits (140), Expect = 2e-08
Identities = 55/241 (22%), Positives = 107/241 (44%), Gaps = 13/241 (5%)
Query: 299 QAIHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQE--ELERQMKELQAANESKQQELE 356
QA + + + K + + LR+K EQE L Q++E +EL+
Sbjct: 2151 QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2210
Query: 357 AVRKKLEEAASRAAEEEKKRLQTQVELQ----ARFSTELEREKLIRQQMEEQVAQKSSEL 412
++ + EAA + ++ E++ +V+++ + E E LI + + E
Sbjct: 2211 RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEA 2270
Query: 413 EQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEE-----ESSKRAELEKW 467
E+ Q E + + QEA + A +D R L ++L+E + + R + E
Sbjct: 2271 EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE 2330
Query: 468 HLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVKK-KLEM 526
L+QQ+ + +A + + E++ + +Q +E LE ER++ LE E ++ KL +
Sbjct: 2331 LLQQQKELAQEQARRLQ-EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRV 2389
Query: 527 A 527
A
Sbjct: 2390 A 2390
Score = 58.2 bits (139), Expect = 2e-08
Identities = 53/204 (25%), Positives = 97/204 (47%), Gaps = 13/204 (6%)
Query: 335 EELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTELERE 394
E L R +E + A + + +E R++L E A EK+R + QA+ E E +
Sbjct: 1339 ETLRRMEEEERLAEQQRAEE----RERLAEVE---AALEKQRQLAEAHAQAKAQAEREAK 1391
Query: 395 KLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQAR-QDEETVRKLQARL 453
+L +Q+M+E+V ++ Q+ R +++ +L+++ E E QA+ + E + + R+
Sbjct: 1392 EL-QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1450
Query: 454 LEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELE---- 509
EE R +LE ++ A +A + E K QA +EA Q++ E
Sbjct: 1451 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1510
Query: 510 RKQALEQYEEVKKKLEMATNKTKS 533
R+ +E VK + E A K ++
Sbjct: 1511 RQAEVELASRVKAEAEAAREKQRA 1534
Score = 55.8 bits (133), Expect = 1e-07
Identities = 48/235 (20%), Positives = 109/235 (46%), Gaps = 15/235 (6%)
Query: 290 DKKKKQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQEELERQMKELQAANE 349
D +++QE IQA+ P +++ R++LR++Q A EE+ER ++++
Sbjct: 1225 DARRRQEQIQAM-------------PLADSQAVREQLRQEQ-ALLEEIERHGEKVEECQR 1270
Query: 350 SKQQELEAVRK-KLEEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQK 408
+Q + A++ +L+ +A E + ++Q+ + ++ +R E
Sbjct: 1271 FAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLT 1330
Query: 409 SSELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWH 468
S ++ + +R +E+ ++ +ER+ + E + Q +L E + +A+ E+
Sbjct: 1331 SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA 1390
Query: 469 LEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVKKK 523
E QQ +Q ++E +++++QE ++QL Q QA + E ++
Sbjct: 1391 KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1445
Score = 55.5 bits (132), Expect = 1e-07
Identities = 69/252 (27%), Positives = 118/252 (46%), Gaps = 32/252 (12%)
Query: 318 EARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAAS--RAAEEEKK 375
EA QRR+ L ++ + ++E ++ +L+ A++S ELE + +E+ R EEE
Sbjct: 1873 EAFQRRR-LEEQAAQHKADIEERLAQLRKASDS---ELERQKGLVEDTLRQRRQVEEEIL 1928
Query: 376 RLQTQVELQARFSTELEREK-LIRQQMEEQVAQKS-SELEQYLQRV---------RELED 424
L+ E A ELE E IR E+ + K +ELE QR RE E+
Sbjct: 1929 ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 1988
Query: 425 MYLKLQEALEDERQARQDE----ETVRKLQARLLE----EESSKRAELEKWHLEQQQAIQ 476
++Q++L E +A + E V +L+A++ E E +++ + L Q+ A +
Sbjct: 1989 ---RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK 2045
Query: 477 TTEAEKQELENQRVLKEQALQEAMEQ----LEQLELERKQALEQYEEVKKKLEMATNKTK 532
+AE++ KEQ LQ+ ++Q L+QL E + A EE ++ A +
Sbjct: 2046 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAA 2105
Query: 533 SWKDKVAHHEGL 544
+ +V E L
Sbjct: 2106 QSRRQVEEAERL 2117
Score = 54.7 bits (130), Expect = 2e-07
Identities = 68/237 (28%), Positives = 116/237 (48%), Gaps = 44/237 (18%)
Query: 322 RRKELRKKQLAEQEEL-ERQMKE-LQAANESKQQELEAV----RKKLEEAASRAAEEEKK 375
R ++L ++ LA+Q L E+ +KE +QA E+ + + EA +K+L + +R +E+K+
Sbjct: 2292 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2351
Query: 376 RLQTQVELQAR-FSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALE 434
++ Q+ + + F LE E+ ++Q+E S+E E+ RV E+ + +E +
Sbjct: 2352 QMAQQLAEETQGFQRTLEAER--QRQLE-----MSAEAERLKLRVAEMSRAQARAEE--D 2402
Query: 435 DERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQ----------AIQTTEAEKQE 484
+R +Q EE KL L + K ++ +++QQ AI E EK++
Sbjct: 2403 AQRFRKQAEEIGEKLHRTELATQE-KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK 2461
Query: 485 L------------ENQRVLKEQALQEAMEQLEQLELERKQALEQ----YEEVKKKLE 525
L E Q V +EQ LQE + L+Q L K +L Q E+ K KLE
Sbjct: 2462 LQQEAKLLQLKSEEMQTVQQEQLLQET-QALQQSFLSEKDSLLQRERFIEQEKAKLE 2517
Score = 53.9 bits (128), Expect = 4e-07
Identities = 69/282 (24%), Positives = 128/282 (45%), Gaps = 52/282 (18%)
Query: 321 QRRKELRKKQLAEQEELERQMKELQAANESKQ--------QELEAVRKKLEEAASRAAEE 372
+R +E + E+E+L+++ K LQ +E Q QE +A+++ +
Sbjct: 2446 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2505
Query: 373 EKKRLQTQVELQARFSTEL-------EREKLIRQQMEEQVAQKSSELEQYLQRVRELEDM 425
E+ Q + +L+ F E+ E ++ +QQME++ + + +E+ +R E E+
Sbjct: 2506 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2565
Query: 426 YLKLQEALED-ERQARQDEETVRKLQARLLEE----ESSKRAEL---EKWHLEQQQAIQT 477
+ QE L+ E+Q RQ EE + + RL E+ E RA L E+ Q A +T
Sbjct: 2566 VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2625
Query: 478 TEAEKQELEN--------------QRVLKEQALQEA----MEQLEQL--------ELERK 511
+ L+ +R + Q LQEA E+L++L EL R+
Sbjct: 2626 LPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARR 2685
Query: 512 QALEQYEEVKKKLEMATNKTKSWKDKVAHHEGLIR-LIEPGS 552
+ + Y ++ + +A K+ +K++ + L R L+ PG+
Sbjct: 2686 EDVRHY--LQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGT 2725
Score = 51.2 bits (121), Expect = 3e-06
Identities = 55/215 (25%), Positives = 100/215 (46%), Gaps = 14/215 (6%)
Query: 322 RRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEE--AASRAAEEEKKRLQT 379
R K+ ++ L E+ E +Q+ E A QE +R+ EE A RA E+ + +
Sbjct: 2257 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2316
Query: 380 QVELQARFSTELEREKLIRQQMEEQVAQKSSEL-EQYLQRVRELEDMYLKLQEALEDERQ 438
Q +A T L+ E + QQ +E +++ L E Q ++L + Q LE ERQ
Sbjct: 2317 QAVQEA---TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2373
Query: 439 ARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQE 498
RQ E + + +L + AE+ + ++ Q + +E+ + E A QE
Sbjct: 2374 -RQLEMSAEAERLKL------RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE 2426
Query: 499 AMEQLEQLELERKQALEQYEEVKKKL-EMATNKTK 532
+ ++ LE++R+Q+ E +++ + E+ K K
Sbjct: 2427 KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK 2461
Score = 48.9 bits (115), Expect = 1e-05
Identities = 48/198 (24%), Positives = 87/198 (43%), Gaps = 2/198 (1%)
Query: 342 KELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQM 401
+E+ A+E + +E +AV L E A + K+L+ Q E Q L E Q++
Sbjct: 1102 EEVLRAHEEQLKEAQAVPATLPEL--EATKASLKKLRAQAEAQQPTFDALRDELRGAQEV 1159
Query: 402 EEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKR 461
E++ Q+ E + ++R RE L+ +A+ + RQ E Q R E +
Sbjct: 1160 GERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPL 1219
Query: 462 AELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVK 521
+ +Q+ IQ + +++ +EQAL E +E+ + E ++ +QY
Sbjct: 1220 GAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAI 1279
Query: 522 KKLEMATNKTKSWKDKVA 539
K E+ K+ + VA
Sbjct: 1280 KDYELQLVTYKAQLEPVA 1297
Score = 35.4 bits (80), Expect = 0.15
Identities = 38/145 (26%), Positives = 63/145 (43%), Gaps = 21/145 (14%)
Query: 323 RKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVE 382
+KE + E E E+++KELQ A + +E R +E Q
Sbjct: 654 KKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESF--------------QAA 699
Query: 383 LQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQD 442
LQ ++S L+ I ++E A Q+ VRE E KLQEAL + +
Sbjct: 700 LQTQWSWMLQLCCCIEAHLKENAAYF-----QFFSDVREAEGQLQKLQEALR-RKYSCDR 753
Query: 443 EETVRKLQARLLEEESSKRAELEKW 467
TV +L+ LL++ ++ +L ++
Sbjct: 754 SATVTRLE-DLLQDAQDEKEQLNEY 777
Score = 30.4 bits (67), Expect = 4.7
Identities = 52/219 (23%), Positives = 85/219 (38%), Gaps = 23/219 (10%)
Query: 311 GSPPPHKEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAA 370
G P + E +QR R QL L K +A E EL+A +
Sbjct: 3187 GEPATYGELQQR---CRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEVPV 3243
Query: 371 EEEKKRLQTQVEL-QARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKL 429
K R T EL + + T +R++L+RQ +V +E + L
Sbjct: 3244 GGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVT---------------VEKVIKIL 3288
Query: 430 QEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQR 489
+E+ RQ+ + L+A + E L + EQ + +TT + EL + R
Sbjct: 3289 ITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVR 3348
Query: 490 VLKEQALQEAMEQLEQLELERKQALEQYEEVKKKLEMAT 528
L + + A LE + K+ + YE +++ L AT
Sbjct: 3349 TLLQGSGCLAGIYLE----DTKEKVSIYEAMRRGLLRAT 3383
Score = 30.4 bits (67), Expect = 4.7
Identities = 23/92 (25%), Positives = 44/92 (47%), Gaps = 5/92 (5%)
Query: 438 QARQDEETVRKLQARLLEEE---SSKRAELEKWHLEQQQAIQTTEAEKQELENQ--RVLK 492
Q +EET R + ++ S + + W + Q I + + + Q RV K
Sbjct: 3556 QVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTK 3615
Query: 493 EQALQEAMEQLEQLELERKQALEQYEEVKKKL 524
E+ + +E +E+ E+ R+Q L Y+ V+++L
Sbjct: 3616 ERMIIIIIEIIEKTEIIRQQGLASYDYVRRRL 3647
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 77.4 bits (189), Expect = 3e-14
Identities = 65/230 (28%), Positives = 116/230 (50%), Gaps = 16/230 (6%)
Query: 317 KEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKR 376
K+A + ++L + +LA QE++ ++ L+ + + E +R+ + E E EK++
Sbjct: 2412 KQAEEIGEKLHRTELATQEKVTL-VQTLEIQRQQSDHDAERLREAIAEL-----EREKEK 2465
Query: 377 LQTQVELQARFSTELEREKLIRQQMEEQVAQKS--SELEQYLQRVRELEDMYLKLQEALE 434
LQ + +L S E++ + + E Q Q+S SE + LQR R +E KL++ +
Sbjct: 2466 LQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQ 2525
Query: 435 DE-RQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQA---IQTTEAEKQELENQRV 490
DE +A+Q E ++ Q ++ +E A +E+ Q +A ++ + E Q+LE QR
Sbjct: 2526 DEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRR 2585
Query: 491 LKEQAL----QEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSWKD 536
+E+ L Q EQL+ LE + + AL EEV AT + +D
Sbjct: 2586 QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRD 2635
Score = 73.6 bits (179), Expect = 5e-13
Identities = 66/236 (27%), Positives = 113/236 (47%), Gaps = 31/236 (13%)
Query: 320 RQRRKELRKKQLAEQEELERQMKELQAANESKQ--QELEAVRKKLEEAASRAAEEEKKRL 377
RQ + E ++K+ AE E R E +AA E ++ Q LE +R + EEA R + E +R
Sbjct: 1505 RQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1564
Query: 378 Q------------TQVELQARFSTELEREKLIRQQMEEQ---VAQKSSELEQYLQRV--- 419
+ + ELQ++ ++ E+ + + ++E+ VAQ E E+ Q+
Sbjct: 1565 RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1624
Query: 420 --------RELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQ 471
RELE LK EAL QA + + QA +++ E + +
Sbjct: 1625 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1684
Query: 472 QQAIQTTEAEKQELENQRVLKEQALQE---AMEQLEQLELERKQALEQYEEVKKKL 524
+QA++ E +QELE QR L E Q+ A ++L +L E +Q +Q + ++++L
Sbjct: 1685 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1740
Score = 73.2 bits (178), Expect = 6e-13
Identities = 76/285 (26%), Positives = 140/285 (49%), Gaps = 50/285 (17%)
Query: 287 SASDKKKKQEW---IQAIHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQ---EELERQ 340
+A+ +K+QE + + + + +L +E+R ++ +++ AE EL +
Sbjct: 1747 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1806
Query: 341 MKELQA-ANESKQQELEAVRKKLEEAASRAAEEEK------------KRLQTQVELQARF 387
L+A A E+K+Q A E+AA + AE E+ RL+T+ E+ +
Sbjct: 1807 AARLRALAEEAKRQRQLAE----EDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK- 1861
Query: 388 STELEREKL---------IRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDE-- 436
E E E+L R+++EEQ AQ +++E+ L ++R+ D L+ Q+ L ++
Sbjct: 1862 EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTL 1921
Query: 437 RQARQDEETVRKLQARLLEEESSKRAELE----KWHLEQQQAIQTTEAEKQELENQRVL- 491
RQ RQ EE + L+A E+ ++ +AELE + + +++ E + E QR L
Sbjct: 1922 RQRRQVEEEILALKAS-FEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 1980
Query: 492 ---------KEQALQEAMEQLEQLELERKQALEQYEEVKKKLEMA 527
E+ +Q+++ E+ +RK ALE+ E +K K+E A
Sbjct: 1981 AEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2025
Score = 70.9 bits (172), Expect = 3e-12
Identities = 69/264 (26%), Positives = 130/264 (49%), Gaps = 15/264 (5%)
Query: 291 KKKKQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQEELERQMKELQAA--N 348
+++ + W + + L +++ + + ++K+ AE+E R E QA
Sbjct: 1632 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1691
Query: 349 ESKQQELEAVRKKLEEAASR--AAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVA 406
E +QELE R+ E A + AAE+E RL+ + E Q +L E+L R Q E A
Sbjct: 1692 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE-QGEQQRQLLEEELARLQREAAAA 1750
Query: 407 -QKSSELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQA-----RLLEEESSK 460
QK ELE L +VR ++ L + E+E ++ E++ ++L+A R L EE+++
Sbjct: 1751 TQKRQELEAELAKVRAEMEVLLASKARAEEESRS-TSEKSKQRLEAEAGRFRELAEEAAR 1809
Query: 461 RAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQ--ALQEAMEQLEQLELERKQALEQYE 518
L + ++Q+ + +A +Q E +RVL E+ A+ EA + E+ K+ + E
Sbjct: 1810 LRALAE-EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE 1868
Query: 519 EVKKKLEMATNKTKSWKDKVAHHE 542
+++ E + + +++ A H+
Sbjct: 1869 RLRRLAEDEAFQRRRLEEQAAQHK 1892
Score = 70.9 bits (172), Expect = 3e-12
Identities = 61/272 (22%), Positives = 127/272 (46%), Gaps = 30/272 (11%)
Query: 285 EISASDKKKKQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRK-----------KQLAE 333
+++A ++++++E + + ++ + ARQR+ L + ++L E
Sbjct: 1978 QLAAEEERRRREAEERVQKSL-------AAEEEAARQRKAALEEVERLKAKVEEARRLRE 2030
Query: 334 QEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTELER 393
+ E E ++LQ A E+ Q+ L+A K A + +E ++ LQ + + + E E
Sbjct: 2031 RAEQE-SARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA 2089
Query: 394 EKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARL 453
+ ++ EE Q E Q ++V E E +L+++ E++ QAR + + +
Sbjct: 2090 ARRAAEEAEEARVQAEREAAQSRRQVEEAE----RLKQSAEEQAQARAQAQAAAEKLRKE 2145
Query: 454 LEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQA 513
E+E+++RA+ E+ L Q+QA E+E + EQ L++ + ++L R Q
Sbjct: 2146 AEQEAARRAQAEQAALRQKQAADA------EMEKHKKFAEQTLRQKAQVEQELTTLRLQ- 2198
Query: 514 LEQYEEVKKKLEMATNKTKSWKDKVAHHEGLI 545
LE+ + K L+ + K+ + A +
Sbjct: 2199 LEETDHQKNLLDEELQRLKAEATEAARQRSQV 2230
Score = 68.9 bits (167), Expect = 1e-11
Identities = 63/228 (27%), Positives = 114/228 (50%), Gaps = 35/228 (15%)
Query: 320 RQRRKELRKKQLAEQEELERQMKELQAANESKQQ-----------ELEAVRKK------L 362
R R +E ++ QEE ER +++Q ++ K+Q E EA R+K L
Sbjct: 1483 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1542
Query: 363 EEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVREL 422
EE +A E E++ Q +VE + LE + R E ++++S E+ Q R L
Sbjct: 1543 EELRLQAEEAERRLRQAEVERARQVQVALETAQ--RSAEAELQSKRASFAEKTAQLERSL 1600
Query: 423 EDMYLKLQEALED-ERQARQD-------EETVRKLQARLLEEESSKRAELEKWHLEQQQA 474
++ ++ + + E+ ER+A+Q EE R+L+ L+ + R L+ + QQ++
Sbjct: 1601 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS 1660
Query: 475 IQTTEAEKQELENQRVLK------EQALQEAMEQLEQLELERKQALEQ 516
+ EAEKQ+ E +R + EQA+++ +L + ELE+++ L +
Sbjct: 1661 LAQAEAEKQKEEAEREARRRGKAEEQAVRQ--RELAEQELEKQRQLAE 1706
Score = 68.9 bits (167), Expect = 1e-11
Identities = 73/244 (29%), Positives = 118/244 (48%), Gaps = 25/244 (10%)
Query: 308 LKLGSPPPHKEARQRRKE------LRKKQLAEQEELERQMKELQAANESKQQELEAVRKK 361
L+LG + E R KE R++QLA +EE R+ E + +S E EA R++
Sbjct: 1950 LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE-ERVQKSLAAEEEAARQR 2008
Query: 362 ---LEEAAS-RAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQ------VAQKSSE 411
LEE +A EE +RL+ + E ++ +L +E ++ E+ V QK E
Sbjct: 2009 KAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE 2068
Query: 412 LEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQ 471
L+Q LQ+ + + D +L+ E R+A ++ E R +QA E + R ++E+ +
Sbjct: 2069 LQQTLQQEQSVLD---QLRGEAEAARRAAEEAEEAR-VQAE--REAAQSRRQVEEAERLK 2122
Query: 472 QQAIQTTEAEKQELENQRVLKEQALQEAME--QLEQLELERKQALEQYEEVKKKLEMATN 529
Q A + +A Q L+++A QEA Q EQ L +KQA + E KK T
Sbjct: 2123 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2182
Query: 530 KTKS 533
+ K+
Sbjct: 2183 RQKA 2186
Score = 65.9 bits (159), Expect = 1e-10
Identities = 82/296 (27%), Positives = 136/296 (45%), Gaps = 29/296 (9%)
Query: 317 KEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKR 376
+ A+Q+ + R ++ AE+E Q+K +A Q E A +K L +A + +EE +R
Sbjct: 1616 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1675
Query: 377 ---LQTQVELQARFSTELEREKLIRQ-QMEEQVAQKSSELEQYLQRVRELEDMYLKLQEA 432
+ + E QA EL ++L +Q Q+ E AQ+ EQ L R+R + + ++
Sbjct: 1676 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1735
Query: 433 LEDERQARQDEETVRKLQARLLEEESSK-RAELEKWHLEQQQAIQ----TTEAEKQELEN 487
LE+E Q E + + LE E +K RAE+E + +A + T+E KQ LE
Sbjct: 1736 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1795
Query: 488 Q----RVLKEQALQ---EAMEQLEQLELERKQALEQYEEVKKKL-----------EMATN 529
+ R L E+A + A E Q +L + A Q E ++ L + T
Sbjct: 1796 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE 1855
Query: 530 KTKSWKDKVAHHEGLIRLIEPGSKNPHLITNWGPAAFTEAELEEREKNWKEKKTTE 585
+ K+K A +E L RL E + + AA +A++EER ++ +E
Sbjct: 1856 AEIALKEKEAENERLRRLAEDEAFQRRRLEE--QAAQHKADIEERLAQLRKASDSE 1909
Score = 63.5 bits (153), Expect = 5e-10
Identities = 55/211 (26%), Positives = 100/211 (47%), Gaps = 23/211 (10%)
Query: 328 KKQLAEQEELERQMKELQAANES-----KQQELEAVRKKLEEAASRAAEEEKKRLQTQVE 382
+K A + ELE ++ +++ E +Q ELEA R++ AAEEE++R + +
Sbjct: 1939 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR-----QLAAEEERRRREAEER 1993
Query: 383 LQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQD 442
+Q + E EE Q+ + LE+ ++R++ + +L+E E E ARQ
Sbjct: 1994 VQKSLAAE-----------EEAARQRKAALEE-VERLKAKVEEARRLRERAEQE-SARQL 2040
Query: 443 EETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQ 502
+ Q RL EE + +++ E QQ +Q ++ +L + +A +EA E
Sbjct: 2041 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2100
Query: 503 LEQLELERKQALEQYEEVKKKLEMATNKTKS 533
Q E E Q+ Q EE ++ + A + ++
Sbjct: 2101 RVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2131
Score = 62.0 bits (149), Expect = 1e-09
Identities = 54/212 (25%), Positives = 111/212 (52%), Gaps = 16/212 (7%)
Query: 317 KEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEE-EKK 375
+EA Q+R + +K A ++++ +ELQ + +Q L+ +R + E AA RAAEE E+
Sbjct: 2044 QEAAQKRLQAEEK--AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE-AARRAAEEAEEA 2100
Query: 376 RLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALED 435
R+Q + E A+ ++E + ++Q EEQ AQ ++ + +++R+ + E
Sbjct: 2101 RVQAERE-AAQSRRQVEEAERLKQSAEEQ-AQARAQAQAAAEKLRK--------EAEQEA 2150
Query: 436 ERQARQDEETVRKLQARLLEEESSKR--AELEKWHLEQQQAIQTTEAEKQELENQRVLKE 493
R+A+ ++ +R+ QA E E K+ + + + +Q + T + +E ++Q+ L +
Sbjct: 2151 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2210
Query: 494 QALQEAMEQLEQLELERKQALEQYEEVKKKLE 525
+ LQ + + +R Q E+ V+ ++E
Sbjct: 2211 EELQRLKAEATEAARQRSQVEEELFSVRVQME 2242
Score = 62.0 bits (149), Expect = 1e-09
Identities = 61/249 (24%), Positives = 119/249 (47%), Gaps = 43/249 (17%)
Query: 317 KEAR---QRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEE 373
+EAR +R ++Q+ E E L++ +E A Q E +RK+ E+ A+R A+ E
Sbjct: 2098 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2157
Query: 374 KKRLQ------TQVELQARFSTELEREKL--------IRQQMEEQVAQKSSELEQYLQRV 419
+ L+ ++E +F+ + R+K +R Q+EE QK+ L++ LQR+
Sbjct: 2158 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL-LDEELQRL 2216
Query: 420 RELEDMYLKLQEALEDER-QARQDEETVRKLQARL------------------LEEESSK 460
+ + + +E+E R E + KL+AR+ L+EE+ K
Sbjct: 2217 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2276
Query: 461 RA----ELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQA--L 514
E + + Q+A + + +++L QR L E+ L+E M+ +++ + +A L
Sbjct: 2277 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2336
Query: 515 EQYEEVKKK 523
+Q +E+ ++
Sbjct: 2337 QQQKELAQE 2345
Score = 59.7 bits (143), Expect = 7e-09
Identities = 70/267 (26%), Positives = 111/267 (41%), Gaps = 17/267 (6%)
Query: 318 EARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRL 377
+A + KEL+++ E E + Q S Q+EL+ +R+ E AE + K
Sbjct: 1389 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE------AEIQAKAR 1442
Query: 378 QTQVELQARFSTELEREKLIRQQMEEQVAQKSS---ELEQYLQRVRELEDMYLKLQEALE 434
Q + ++R E E +++R Q+E Q+ EL+ R E E + QE E
Sbjct: 1443 QAEAAERSRLRIE-EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1501
Query: 435 DERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQ 494
R+ QD E+ RK QA +E S +AE E E+Q+A+Q E + + E Q
Sbjct: 1502 RLRRQVQD-ESQRKRQAE-VELASRVKAEAEAAR-EKQRALQALEELRLQAEEAERRLRQ 1558
Query: 495 ALQEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSWKDKVAHHEGLIRLIEPGSKN 554
A E Q+ Q+ LE Q + E K+ A + + H + +L E +
Sbjct: 1559 AEVERARQV-QVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1617
Query: 555 PHLITNWGPAAFTEAELEEREKNWKEK 581
A E E + W+ K
Sbjct: 1618 AQ---QQAEAERAREEAERELERWQLK 1641
Score = 59.3 bits (142), Expect = 9e-09
Identities = 49/217 (22%), Positives = 105/217 (48%), Gaps = 19/217 (8%)
Query: 331 LAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTE 390
L EE ER ++ +A + E+EA +K + A A+ + + + ELQ R E
Sbjct: 1345 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1404
Query: 391 LEREKLIRQQMEEQVAQKSSELEQYLQRVRELE--DMYLKLQEALEDERQARQDEETVRK 448
+ R R++ Q+ +++ LQ++R+ ++ K ++A ER + EE +R
Sbjct: 1405 VVR----REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1460
Query: 449 LQARLLEEESSK----------RAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQE 498
++ +L E + RA E+ +++QA + E +++++++ K QA E
Sbjct: 1461 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1520
Query: 499 AMEQLE---QLELERKQALEQYEEVKKKLEMATNKTK 532
+++ + E+++AL+ EE++ + E A + +
Sbjct: 1521 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR 1557
Score = 59.3 bits (142), Expect = 9e-09
Identities = 65/229 (28%), Positives = 123/229 (53%), Gaps = 34/229 (14%)
Query: 319 ARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAA------SRAAEE 372
A +++++L + + + ER+ KELQ ++ + E VR+ EEAA R+ +E
Sbjct: 1372 ALEKQRQLAEAHAQAKAQAEREAKELQ-----QRMQEEVVRR--EEAAVDAQQQKRSIQE 1424
Query: 373 EKKRLQ--TQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVR-----ELEDM 425
E ++L+ ++ E+QA+ + + E + R ++EE++ +LE +R R EL+ +
Sbjct: 1425 ELQQLRQSSEAEIQAK-ARQAEAAERSRLRIEEEIRVVRLQLEA-TERQRGGAEGELQAL 1482
Query: 426 YLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQEL 485
+ +EA +RQA+++ E +R R +++ES ++ + E +E ++ EAE
Sbjct: 1483 RARAEEAEAQKRQAQEEAERLR----RQVQDESQRKRQAE---VELASRVK-AEAEAAR- 1533
Query: 486 ENQRVLKEQALQEAMEQLEQLELERKQA-LEQYEEVKKKLEMATNKTKS 533
E QR L QAL+E Q E+ E +QA +E+ +V+ LE A ++
Sbjct: 1534 EKQRAL--QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1580
Score = 58.5 bits (140), Expect = 2e-08
Identities = 55/241 (22%), Positives = 107/241 (44%), Gaps = 13/241 (5%)
Query: 299 QAIHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQE--ELERQMKELQAANESKQQELE 356
QA + + + K + + LR+K EQE L Q++E +EL+
Sbjct: 2155 QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2214
Query: 357 AVRKKLEEAASRAAEEEKKRLQTQVELQ----ARFSTELEREKLIRQQMEEQVAQKSSEL 412
++ + EAA + ++ E++ +V+++ + E E LI + + E
Sbjct: 2215 RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEA 2274
Query: 413 EQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEE-----ESSKRAELEKW 467
E+ Q E + + QEA + A +D R L ++L+E + + R + E
Sbjct: 2275 EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE 2334
Query: 468 HLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVKK-KLEM 526
L+QQ+ + +A + + E++ + +Q +E LE ER++ LE E ++ KL +
Sbjct: 2335 LLQQQKELAQEQARRLQ-EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRV 2393
Query: 527 A 527
A
Sbjct: 2394 A 2394
Score = 58.2 bits (139), Expect = 2e-08
Identities = 53/204 (25%), Positives = 97/204 (47%), Gaps = 13/204 (6%)
Query: 335 EELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTELERE 394
E L R +E + A + + +E R++L E A EK+R + QA+ E E +
Sbjct: 1343 ETLRRMEEEERLAEQQRAEE----RERLAEVE---AALEKQRQLAEAHAQAKAQAEREAK 1395
Query: 395 KLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQAR-QDEETVRKLQARL 453
+L +Q+M+E+V ++ Q+ R +++ +L+++ E E QA+ + E + + R+
Sbjct: 1396 EL-QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1454
Query: 454 LEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELE---- 509
EE R +LE ++ A +A + E K QA +EA Q++ E
Sbjct: 1455 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1514
Query: 510 RKQALEQYEEVKKKLEMATNKTKS 533
R+ +E VK + E A K ++
Sbjct: 1515 RQAEVELASRVKAEAEAAREKQRA 1538
Score = 55.8 bits (133), Expect = 1e-07
Identities = 48/235 (20%), Positives = 109/235 (46%), Gaps = 15/235 (6%)
Query: 290 DKKKKQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQEELERQMKELQAANE 349
D +++QE IQA+ P +++ R++LR++Q A EE+ER ++++
Sbjct: 1229 DARRRQEQIQAM-------------PLADSQAVREQLRQEQ-ALLEEIERHGEKVEECQR 1274
Query: 350 SKQQELEAVRK-KLEEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQK 408
+Q + A++ +L+ +A E + ++Q+ + ++ +R E
Sbjct: 1275 FAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLT 1334
Query: 409 SSELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWH 468
S ++ + +R +E+ ++ +ER+ + E + Q +L E + +A+ E+
Sbjct: 1335 SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA 1394
Query: 469 LEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVKKK 523
E QQ +Q ++E +++++QE ++QL Q QA + E ++
Sbjct: 1395 KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1449
Score = 55.5 bits (132), Expect = 1e-07
Identities = 69/252 (27%), Positives = 118/252 (46%), Gaps = 32/252 (12%)
Query: 318 EARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAAS--RAAEEEKK 375
EA QRR+ L ++ + ++E ++ +L+ A++S ELE + +E+ R EEE
Sbjct: 1877 EAFQRRR-LEEQAAQHKADIEERLAQLRKASDS---ELERQKGLVEDTLRQRRQVEEEIL 1932
Query: 376 RLQTQVELQARFSTELEREK-LIRQQMEEQVAQKS-SELEQYLQRV---------RELED 424
L+ E A ELE E IR E+ + K +ELE QR RE E+
Sbjct: 1933 ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 1992
Query: 425 MYLKLQEALEDERQARQDE----ETVRKLQARLLE----EESSKRAELEKWHLEQQQAIQ 476
++Q++L E +A + E V +L+A++ E E +++ + L Q+ A +
Sbjct: 1993 ---RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK 2049
Query: 477 TTEAEKQELENQRVLKEQALQEAMEQ----LEQLELERKQALEQYEEVKKKLEMATNKTK 532
+AE++ KEQ LQ+ ++Q L+QL E + A EE ++ A +
Sbjct: 2050 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAA 2109
Query: 533 SWKDKVAHHEGL 544
+ +V E L
Sbjct: 2110 QSRRQVEEAERL 2121
Score = 54.7 bits (130), Expect = 2e-07
Identities = 68/237 (28%), Positives = 116/237 (48%), Gaps = 44/237 (18%)
Query: 322 RRKELRKKQLAEQEEL-ERQMKE-LQAANESKQQELEAV----RKKLEEAASRAAEEEKK 375
R ++L ++ LA+Q L E+ +KE +QA E+ + + EA +K+L + +R +E+K+
Sbjct: 2296 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2355
Query: 376 RLQTQVELQAR-FSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALE 434
++ Q+ + + F LE E+ ++Q+E S+E E+ RV E+ + +E +
Sbjct: 2356 QMAQQLAEETQGFQRTLEAER--QRQLE-----MSAEAERLKLRVAEMSRAQARAEE--D 2406
Query: 435 DERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQ----------AIQTTEAEKQE 484
+R +Q EE KL L + K ++ +++QQ AI E EK++
Sbjct: 2407 AQRFRKQAEEIGEKLHRTELATQE-KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK 2465
Query: 485 L------------ENQRVLKEQALQEAMEQLEQLELERKQALEQ----YEEVKKKLE 525
L E Q V +EQ LQE + L+Q L K +L Q E+ K KLE
Sbjct: 2466 LQQEAKLLQLKSEEMQTVQQEQLLQET-QALQQSFLSEKDSLLQRERFIEQEKAKLE 2521
Score = 53.9 bits (128), Expect = 4e-07
Identities = 69/282 (24%), Positives = 128/282 (45%), Gaps = 52/282 (18%)
Query: 321 QRRKELRKKQLAEQEELERQMKELQAANESKQ--------QELEAVRKKLEEAASRAAEE 372
+R +E + E+E+L+++ K LQ +E Q QE +A+++ +
Sbjct: 2450 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2509
Query: 373 EKKRLQTQVELQARFSTEL-------EREKLIRQQMEEQVAQKSSELEQYLQRVRELEDM 425
E+ Q + +L+ F E+ E ++ +QQME++ + + +E+ +R E E+
Sbjct: 2510 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2569
Query: 426 YLKLQEALED-ERQARQDEETVRKLQARLLEE----ESSKRAEL---EKWHLEQQQAIQT 477
+ QE L+ E+Q RQ EE + + RL E+ E RA L E+ Q A +T
Sbjct: 2570 VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2629
Query: 478 TEAEKQELEN--------------QRVLKEQALQEA----MEQLEQL--------ELERK 511
+ L+ +R + Q LQEA E+L++L EL R+
Sbjct: 2630 LPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARR 2689
Query: 512 QALEQYEEVKKKLEMATNKTKSWKDKVAHHEGLIR-LIEPGS 552
+ + Y ++ + +A K+ +K++ + L R L+ PG+
Sbjct: 2690 EDVRHY--LQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGT 2729
Score = 51.2 bits (121), Expect = 3e-06
Identities = 55/215 (25%), Positives = 100/215 (46%), Gaps = 14/215 (6%)
Query: 322 RRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEE--AASRAAEEEKKRLQT 379
R K+ ++ L E+ E +Q+ E A QE +R+ EE A RA E+ + +
Sbjct: 2261 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2320
Query: 380 QVELQARFSTELEREKLIRQQMEEQVAQKSSEL-EQYLQRVRELEDMYLKLQEALEDERQ 438
Q +A T L+ E + QQ +E +++ L E Q ++L + Q LE ERQ
Sbjct: 2321 QAVQEA---TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2377
Query: 439 ARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQE 498
RQ E + + +L + AE+ + ++ Q + +E+ + E A QE
Sbjct: 2378 -RQLEMSAEAERLKL------RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE 2430
Query: 499 AMEQLEQLELERKQALEQYEEVKKKL-EMATNKTK 532
+ ++ LE++R+Q+ E +++ + E+ K K
Sbjct: 2431 KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK 2465
Score = 48.9 bits (115), Expect = 1e-05
Identities = 48/198 (24%), Positives = 87/198 (43%), Gaps = 2/198 (1%)
Query: 342 KELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQM 401
+E+ A+E + +E +AV L E A + K+L+ Q E Q L E Q++
Sbjct: 1106 EEVLRAHEEQLKEAQAVPATLPEL--EATKASLKKLRAQAEAQQPTFDALRDELRGAQEV 1163
Query: 402 EEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKR 461
E++ Q+ E + ++R RE L+ +A+ + RQ E Q R E +
Sbjct: 1164 GERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPL 1223
Query: 462 AELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVK 521
+ +Q+ IQ + +++ +EQAL E +E+ + E ++ +QY
Sbjct: 1224 GAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAI 1283
Query: 522 KKLEMATNKTKSWKDKVA 539
K E+ K+ + VA
Sbjct: 1284 KDYELQLVTYKAQLEPVA 1301
Score = 35.4 bits (80), Expect = 0.15
Identities = 38/145 (26%), Positives = 63/145 (43%), Gaps = 21/145 (14%)
Query: 323 RKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVE 382
+KE + E E E+++KELQ A + +E R +E Q
Sbjct: 658 KKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESF--------------QAA 703
Query: 383 LQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQD 442
LQ ++S L+ I ++E A Q+ VRE E KLQEAL + +
Sbjct: 704 LQTQWSWMLQLCCCIEAHLKENAAYF-----QFFSDVREAEGQLQKLQEALR-RKYSCDR 757
Query: 443 EETVRKLQARLLEEESSKRAELEKW 467
TV +L+ LL++ ++ +L ++
Sbjct: 758 SATVTRLE-DLLQDAQDEKEQLNEY 781
Score = 30.4 bits (67), Expect = 4.7
Identities = 52/219 (23%), Positives = 85/219 (38%), Gaps = 23/219 (10%)
Query: 311 GSPPPHKEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAA 370
G P + E +QR R QL L K +A E EL+A +
Sbjct: 3191 GEPATYGELQQR---CRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEVPV 3247
Query: 371 EEEKKRLQTQVEL-QARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKL 429
K R T EL + + T +R++L+RQ +V +E + L
Sbjct: 3248 GGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVT---------------VEKVIKIL 3292
Query: 430 QEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQR 489
+E+ RQ+ + L+A + E L + EQ + +TT + EL + R
Sbjct: 3293 ITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVR 3352
Query: 490 VLKEQALQEAMEQLEQLELERKQALEQYEEVKKKLEMAT 528
L + + A LE + K+ + YE +++ L AT
Sbjct: 3353 TLLQGSGCLAGIYLE----DTKEKVSIYEAMRRGLLRAT 3387
Score = 30.4 bits (67), Expect = 4.7
Identities = 23/92 (25%), Positives = 44/92 (47%), Gaps = 5/92 (5%)
Query: 438 QARQDEETVRKLQARLLEEE---SSKRAELEKWHLEQQQAIQTTEAEKQELENQ--RVLK 492
Q +EET R + ++ S + + W + Q I + + + Q RV K
Sbjct: 3560 QVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTK 3619
Query: 493 EQALQEAMEQLEQLELERKQALEQYEEVKKKL 524
E+ + +E +E+ E+ R+Q L Y+ V+++L
Sbjct: 3620 ERMIIIIIEIIEKTEIIRQQGLASYDYVRRRL 3651
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 77.4 bits (189), Expect = 3e-14
Identities = 65/230 (28%), Positives = 116/230 (50%), Gaps = 16/230 (6%)
Query: 317 KEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKR 376
K+A + ++L + +LA QE++ ++ L+ + + E +R+ + E E EK++
Sbjct: 2408 KQAEEIGEKLHRTELATQEKVTL-VQTLEIQRQQSDHDAERLREAIAEL-----EREKEK 2461
Query: 377 LQTQVELQARFSTELEREKLIRQQMEEQVAQKS--SELEQYLQRVRELEDMYLKLQEALE 434
LQ + +L S E++ + + E Q Q+S SE + LQR R +E KL++ +
Sbjct: 2462 LQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQ 2521
Query: 435 DE-RQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQA---IQTTEAEKQELENQRV 490
DE +A+Q E ++ Q ++ +E A +E+ Q +A ++ + E Q+LE QR
Sbjct: 2522 DEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRR 2581
Query: 491 LKEQAL----QEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSWKD 536
+E+ L Q EQL+ LE + + AL EEV AT + +D
Sbjct: 2582 QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRD 2631
Score = 73.6 bits (179), Expect = 5e-13
Identities = 66/236 (27%), Positives = 113/236 (47%), Gaps = 31/236 (13%)
Query: 320 RQRRKELRKKQLAEQEELERQMKELQAANESKQ--QELEAVRKKLEEAASRAAEEEKKRL 377
RQ + E ++K+ AE E R E +AA E ++ Q LE +R + EEA R + E +R
Sbjct: 1501 RQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1560
Query: 378 Q------------TQVELQARFSTELEREKLIRQQMEEQ---VAQKSSELEQYLQRV--- 419
+ + ELQ++ ++ E+ + + ++E+ VAQ E E+ Q+
Sbjct: 1561 RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1620
Query: 420 --------RELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQ 471
RELE LK EAL QA + + QA +++ E + +
Sbjct: 1621 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1680
Query: 472 QQAIQTTEAEKQELENQRVLKEQALQE---AMEQLEQLELERKQALEQYEEVKKKL 524
+QA++ E +QELE QR L E Q+ A ++L +L E +Q +Q + ++++L
Sbjct: 1681 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1736
Score = 73.2 bits (178), Expect = 6e-13
Identities = 76/285 (26%), Positives = 140/285 (49%), Gaps = 50/285 (17%)
Query: 287 SASDKKKKQEW---IQAIHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQ---EELERQ 340
+A+ +K+QE + + + + +L +E+R ++ +++ AE EL +
Sbjct: 1743 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1802
Query: 341 MKELQA-ANESKQQELEAVRKKLEEAASRAAEEEK------------KRLQTQVELQARF 387
L+A A E+K+Q A E+AA + AE E+ RL+T+ E+ +
Sbjct: 1803 AARLRALAEEAKRQRQLAE----EDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK- 1857
Query: 388 STELEREKL---------IRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDE-- 436
E E E+L R+++EEQ AQ +++E+ L ++R+ D L+ Q+ L ++
Sbjct: 1858 EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTL 1917
Query: 437 RQARQDEETVRKLQARLLEEESSKRAELE----KWHLEQQQAIQTTEAEKQELENQRVL- 491
RQ RQ EE + L+A E+ ++ +AELE + + +++ E + E QR L
Sbjct: 1918 RQRRQVEEEILALKAS-FEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 1976
Query: 492 ---------KEQALQEAMEQLEQLELERKQALEQYEEVKKKLEMA 527
E+ +Q+++ E+ +RK ALE+ E +K K+E A
Sbjct: 1977 AEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2021
Score = 70.9 bits (172), Expect = 3e-12
Identities = 69/264 (26%), Positives = 130/264 (49%), Gaps = 15/264 (5%)
Query: 291 KKKKQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQEELERQMKELQAA--N 348
+++ + W + + L +++ + + ++K+ AE+E R E QA
Sbjct: 1628 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1687
Query: 349 ESKQQELEAVRKKLEEAASR--AAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVA 406
E +QELE R+ E A + AAE+E RL+ + E Q +L E+L R Q E A
Sbjct: 1688 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE-QGEQQRQLLEEELARLQREAAAA 1746
Query: 407 -QKSSELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQA-----RLLEEESSK 460
QK ELE L +VR ++ L + E+E ++ E++ ++L+A R L EE+++
Sbjct: 1747 TQKRQELEAELAKVRAEMEVLLASKARAEEESRS-TSEKSKQRLEAEAGRFRELAEEAAR 1805
Query: 461 RAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQ--ALQEAMEQLEQLELERKQALEQYE 518
L + ++Q+ + +A +Q E +RVL E+ A+ EA + E+ K+ + E
Sbjct: 1806 LRALAE-EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE 1864
Query: 519 EVKKKLEMATNKTKSWKDKVAHHE 542
+++ E + + +++ A H+
Sbjct: 1865 RLRRLAEDEAFQRRRLEEQAAQHK 1888
Score = 70.9 bits (172), Expect = 3e-12
Identities = 61/272 (22%), Positives = 127/272 (46%), Gaps = 30/272 (11%)
Query: 285 EISASDKKKKQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRK-----------KQLAE 333
+++A ++++++E + + ++ + ARQR+ L + ++L E
Sbjct: 1974 QLAAEEERRRREAEERVQKSL-------AAEEEAARQRKAALEEVERLKAKVEEARRLRE 2026
Query: 334 QEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTELER 393
+ E E ++LQ A E+ Q+ L+A K A + +E ++ LQ + + + E E
Sbjct: 2027 RAEQE-SARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA 2085
Query: 394 EKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARL 453
+ ++ EE Q E Q ++V E E +L+++ E++ QAR + + +
Sbjct: 2086 ARRAAEEAEEARVQAEREAAQSRRQVEEAE----RLKQSAEEQAQARAQAQAAAEKLRKE 2141
Query: 454 LEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQA 513
E+E+++RA+ E+ L Q+QA E+E + EQ L++ + ++L R Q
Sbjct: 2142 AEQEAARRAQAEQAALRQKQAADA------EMEKHKKFAEQTLRQKAQVEQELTTLRLQ- 2194
Query: 514 LEQYEEVKKKLEMATNKTKSWKDKVAHHEGLI 545
LE+ + K L+ + K+ + A +
Sbjct: 2195 LEETDHQKNLLDEELQRLKAEATEAARQRSQV 2226
Score = 68.9 bits (167), Expect = 1e-11
Identities = 63/228 (27%), Positives = 114/228 (50%), Gaps = 35/228 (15%)
Query: 320 RQRRKELRKKQLAEQEELERQMKELQAANESKQQ-----------ELEAVRKK------L 362
R R +E ++ QEE ER +++Q ++ K+Q E EA R+K L
Sbjct: 1479 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1538
Query: 363 EEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVREL 422
EE +A E E++ Q +VE + LE + R E ++++S E+ Q R L
Sbjct: 1539 EELRLQAEEAERRLRQAEVERARQVQVALETAQ--RSAEAELQSKRASFAEKTAQLERSL 1596
Query: 423 EDMYLKLQEALED-ERQARQD-------EETVRKLQARLLEEESSKRAELEKWHLEQQQA 474
++ ++ + + E+ ER+A+Q EE R+L+ L+ + R L+ + QQ++
Sbjct: 1597 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS 1656
Query: 475 IQTTEAEKQELENQRVLK------EQALQEAMEQLEQLELERKQALEQ 516
+ EAEKQ+ E +R + EQA+++ +L + ELE+++ L +
Sbjct: 1657 LAQAEAEKQKEEAEREARRRGKAEEQAVRQ--RELAEQELEKQRQLAE 1702
Score = 68.9 bits (167), Expect = 1e-11
Identities = 73/244 (29%), Positives = 118/244 (48%), Gaps = 25/244 (10%)
Query: 308 LKLGSPPPHKEARQRRKE------LRKKQLAEQEELERQMKELQAANESKQQELEAVRKK 361
L+LG + E R KE R++QLA +EE R+ E + +S E EA R++
Sbjct: 1946 LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE-ERVQKSLAAEEEAARQR 2004
Query: 362 ---LEEAAS-RAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQ------VAQKSSE 411
LEE +A EE +RL+ + E ++ +L +E ++ E+ V QK E
Sbjct: 2005 KAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE 2064
Query: 412 LEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQ 471
L+Q LQ+ + + D +L+ E R+A ++ E R +QA E + R ++E+ +
Sbjct: 2065 LQQTLQQEQSVLD---QLRGEAEAARRAAEEAEEAR-VQAE--REAAQSRRQVEEAERLK 2118
Query: 472 QQAIQTTEAEKQELENQRVLKEQALQEAME--QLEQLELERKQALEQYEEVKKKLEMATN 529
Q A + +A Q L+++A QEA Q EQ L +KQA + E KK T
Sbjct: 2119 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2178
Query: 530 KTKS 533
+ K+
Sbjct: 2179 RQKA 2182
Score = 65.9 bits (159), Expect = 1e-10
Identities = 82/296 (27%), Positives = 136/296 (45%), Gaps = 29/296 (9%)
Query: 317 KEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKR 376
+ A+Q+ + R ++ AE+E Q+K +A Q E A +K L +A + +EE +R
Sbjct: 1612 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1671
Query: 377 ---LQTQVELQARFSTELEREKLIRQ-QMEEQVAQKSSELEQYLQRVRELEDMYLKLQEA 432
+ + E QA EL ++L +Q Q+ E AQ+ EQ L R+R + + ++
Sbjct: 1672 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1731
Query: 433 LEDERQARQDEETVRKLQARLLEEESSK-RAELEKWHLEQQQAIQ----TTEAEKQELEN 487
LE+E Q E + + LE E +K RAE+E + +A + T+E KQ LE
Sbjct: 1732 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1791
Query: 488 Q----RVLKEQALQ---EAMEQLEQLELERKQALEQYEEVKKKL-----------EMATN 529
+ R L E+A + A E Q +L + A Q E ++ L + T
Sbjct: 1792 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE 1851
Query: 530 KTKSWKDKVAHHEGLIRLIEPGSKNPHLITNWGPAAFTEAELEEREKNWKEKKTTE 585
+ K+K A +E L RL E + + AA +A++EER ++ +E
Sbjct: 1852 AEIALKEKEAENERLRRLAEDEAFQRRRLEE--QAAQHKADIEERLAQLRKASDSE 1905
Score = 63.5 bits (153), Expect = 5e-10
Identities = 55/211 (26%), Positives = 100/211 (47%), Gaps = 23/211 (10%)
Query: 328 KKQLAEQEELERQMKELQAANES-----KQQELEAVRKKLEEAASRAAEEEKKRLQTQVE 382
+K A + ELE ++ +++ E +Q ELEA R++ AAEEE++R + +
Sbjct: 1935 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR-----QLAAEEERRRREAEER 1989
Query: 383 LQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQD 442
+Q + E EE Q+ + LE+ ++R++ + +L+E E E ARQ
Sbjct: 1990 VQKSLAAE-----------EEAARQRKAALEE-VERLKAKVEEARRLRERAEQE-SARQL 2036
Query: 443 EETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQ 502
+ Q RL EE + +++ E QQ +Q ++ +L + +A +EA E
Sbjct: 2037 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2096
Query: 503 LEQLELERKQALEQYEEVKKKLEMATNKTKS 533
Q E E Q+ Q EE ++ + A + ++
Sbjct: 2097 RVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2127
Score = 62.0 bits (149), Expect = 1e-09
Identities = 54/212 (25%), Positives = 111/212 (52%), Gaps = 16/212 (7%)
Query: 317 KEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEE-EKK 375
+EA Q+R + +K A ++++ +ELQ + +Q L+ +R + E AA RAAEE E+
Sbjct: 2040 QEAAQKRLQAEEK--AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE-AARRAAEEAEEA 2096
Query: 376 RLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALED 435
R+Q + E A+ ++E + ++Q EEQ AQ ++ + +++R+ + E
Sbjct: 2097 RVQAERE-AAQSRRQVEEAERLKQSAEEQ-AQARAQAQAAAEKLRK--------EAEQEA 2146
Query: 436 ERQARQDEETVRKLQARLLEEESSKR--AELEKWHLEQQQAIQTTEAEKQELENQRVLKE 493
R+A+ ++ +R+ QA E E K+ + + + +Q + T + +E ++Q+ L +
Sbjct: 2147 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2206
Query: 494 QALQEAMEQLEQLELERKQALEQYEEVKKKLE 525
+ LQ + + +R Q E+ V+ ++E
Sbjct: 2207 EELQRLKAEATEAARQRSQVEEELFSVRVQME 2238
Score = 62.0 bits (149), Expect = 1e-09
Identities = 61/249 (24%), Positives = 119/249 (47%), Gaps = 43/249 (17%)
Query: 317 KEAR---QRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEE 373
+EAR +R ++Q+ E E L++ +E A Q E +RK+ E+ A+R A+ E
Sbjct: 2094 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2153
Query: 374 KKRLQ------TQVELQARFSTELEREKL--------IRQQMEEQVAQKSSELEQYLQRV 419
+ L+ ++E +F+ + R+K +R Q+EE QK+ L++ LQR+
Sbjct: 2154 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL-LDEELQRL 2212
Query: 420 RELEDMYLKLQEALEDER-QARQDEETVRKLQARL------------------LEEESSK 460
+ + + +E+E R E + KL+AR+ L+EE+ K
Sbjct: 2213 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2272
Query: 461 RA----ELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQA--L 514
E + + Q+A + + +++L QR L E+ L+E M+ +++ + +A L
Sbjct: 2273 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2332
Query: 515 EQYEEVKKK 523
+Q +E+ ++
Sbjct: 2333 QQQKELAQE 2341
Score = 59.7 bits (143), Expect = 7e-09
Identities = 70/267 (26%), Positives = 111/267 (41%), Gaps = 17/267 (6%)
Query: 318 EARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRL 377
+A + KEL+++ E E + Q S Q+EL+ +R+ E AE + K
Sbjct: 1385 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE------AEIQAKAR 1438
Query: 378 QTQVELQARFSTELEREKLIRQQMEEQVAQKSS---ELEQYLQRVRELEDMYLKLQEALE 434
Q + ++R E E +++R Q+E Q+ EL+ R E E + QE E
Sbjct: 1439 QAEAAERSRLRIE-EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1497
Query: 435 DERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQ 494
R+ QD E+ RK QA +E S +AE E E+Q+A+Q E + + E Q
Sbjct: 1498 RLRRQVQD-ESQRKRQAE-VELASRVKAEAEAAR-EKQRALQALEELRLQAEEAERRLRQ 1554
Query: 495 ALQEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSWKDKVAHHEGLIRLIEPGSKN 554
A E Q+ Q+ LE Q + E K+ A + + H + +L E +
Sbjct: 1555 AEVERARQV-QVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1613
Query: 555 PHLITNWGPAAFTEAELEEREKNWKEK 581
A E E + W+ K
Sbjct: 1614 AQ---QQAEAERAREEAERELERWQLK 1637
Score = 59.3 bits (142), Expect = 9e-09
Identities = 49/217 (22%), Positives = 105/217 (48%), Gaps = 19/217 (8%)
Query: 331 LAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTE 390
L EE ER ++ +A + E+EA +K + A A+ + + + ELQ R E
Sbjct: 1341 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1400
Query: 391 LEREKLIRQQMEEQVAQKSSELEQYLQRVRELE--DMYLKLQEALEDERQARQDEETVRK 448
+ R R++ Q+ +++ LQ++R+ ++ K ++A ER + EE +R
Sbjct: 1401 VVR----REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1456
Query: 449 LQARLLEEESSK----------RAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQE 498
++ +L E + RA E+ +++QA + E +++++++ K QA E
Sbjct: 1457 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1516
Query: 499 AMEQLE---QLELERKQALEQYEEVKKKLEMATNKTK 532
+++ + E+++AL+ EE++ + E A + +
Sbjct: 1517 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR 1553
Score = 59.3 bits (142), Expect = 9e-09
Identities = 65/229 (28%), Positives = 123/229 (53%), Gaps = 34/229 (14%)
Query: 319 ARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAA------SRAAEE 372
A +++++L + + + ER+ KELQ ++ + E VR+ EEAA R+ +E
Sbjct: 1368 ALEKQRQLAEAHAQAKAQAEREAKELQ-----QRMQEEVVRR--EEAAVDAQQQKRSIQE 1420
Query: 373 EKKRLQ--TQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVR-----ELEDM 425
E ++L+ ++ E+QA+ + + E + R ++EE++ +LE +R R EL+ +
Sbjct: 1421 ELQQLRQSSEAEIQAK-ARQAEAAERSRLRIEEEIRVVRLQLEA-TERQRGGAEGELQAL 1478
Query: 426 YLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQEL 485
+ +EA +RQA+++ E +R R +++ES ++ + E +E ++ EAE
Sbjct: 1479 RARAEEAEAQKRQAQEEAERLR----RQVQDESQRKRQAE---VELASRVK-AEAEAAR- 1529
Query: 486 ENQRVLKEQALQEAMEQLEQLELERKQA-LEQYEEVKKKLEMATNKTKS 533
E QR L QAL+E Q E+ E +QA +E+ +V+ LE A ++
Sbjct: 1530 EKQRAL--QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1576
Score = 58.5 bits (140), Expect = 2e-08
Identities = 55/241 (22%), Positives = 107/241 (44%), Gaps = 13/241 (5%)
Query: 299 QAIHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQE--ELERQMKELQAANESKQQELE 356
QA + + + K + + LR+K EQE L Q++E +EL+
Sbjct: 2151 QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2210
Query: 357 AVRKKLEEAASRAAEEEKKRLQTQVELQ----ARFSTELEREKLIRQQMEEQVAQKSSEL 412
++ + EAA + ++ E++ +V+++ + E E LI + + E
Sbjct: 2211 RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEA 2270
Query: 413 EQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEE-----ESSKRAELEKW 467
E+ Q E + + QEA + A +D R L ++L+E + + R + E
Sbjct: 2271 EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE 2330
Query: 468 HLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVKK-KLEM 526
L+QQ+ + +A + + E++ + +Q +E LE ER++ LE E ++ KL +
Sbjct: 2331 LLQQQKELAQEQARRLQ-EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRV 2389
Query: 527 A 527
A
Sbjct: 2390 A 2390
Score = 58.2 bits (139), Expect = 2e-08
Identities = 53/204 (25%), Positives = 97/204 (47%), Gaps = 13/204 (6%)
Query: 335 EELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTELERE 394
E L R +E + A + + +E R++L E A EK+R + QA+ E E +
Sbjct: 1339 ETLRRMEEEERLAEQQRAEE----RERLAEVE---AALEKQRQLAEAHAQAKAQAEREAK 1391
Query: 395 KLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQAR-QDEETVRKLQARL 453
+L +Q+M+E+V ++ Q+ R +++ +L+++ E E QA+ + E + + R+
Sbjct: 1392 EL-QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1450
Query: 454 LEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELE---- 509
EE R +LE ++ A +A + E K QA +EA Q++ E
Sbjct: 1451 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1510
Query: 510 RKQALEQYEEVKKKLEMATNKTKS 533
R+ +E VK + E A K ++
Sbjct: 1511 RQAEVELASRVKAEAEAAREKQRA 1534
Score = 55.8 bits (133), Expect = 1e-07
Identities = 48/235 (20%), Positives = 109/235 (46%), Gaps = 15/235 (6%)
Query: 290 DKKKKQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQEELERQMKELQAANE 349
D +++QE IQA+ P +++ R++LR++Q A EE+ER ++++
Sbjct: 1225 DARRRQEQIQAM-------------PLADSQAVREQLRQEQ-ALLEEIERHGEKVEECQR 1270
Query: 350 SKQQELEAVRK-KLEEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQK 408
+Q + A++ +L+ +A E + ++Q+ + ++ +R E
Sbjct: 1271 FAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLT 1330
Query: 409 SSELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWH 468
S ++ + +R +E+ ++ +ER+ + E + Q +L E + +A+ E+
Sbjct: 1331 SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA 1390
Query: 469 LEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVKKK 523
E QQ +Q ++E +++++QE ++QL Q QA + E ++
Sbjct: 1391 KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1445
Score = 55.5 bits (132), Expect = 1e-07
Identities = 69/252 (27%), Positives = 118/252 (46%), Gaps = 32/252 (12%)
Query: 318 EARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAAS--RAAEEEKK 375
EA QRR+ L ++ + ++E ++ +L+ A++S ELE + +E+ R EEE
Sbjct: 1873 EAFQRRR-LEEQAAQHKADIEERLAQLRKASDS---ELERQKGLVEDTLRQRRQVEEEIL 1928
Query: 376 RLQTQVELQARFSTELEREK-LIRQQMEEQVAQKS-SELEQYLQRV---------RELED 424
L+ E A ELE E IR E+ + K +ELE QR RE E+
Sbjct: 1929 ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 1988
Query: 425 MYLKLQEALEDERQARQDE----ETVRKLQARLLE----EESSKRAELEKWHLEQQQAIQ 476
++Q++L E +A + E V +L+A++ E E +++ + L Q+ A +
Sbjct: 1989 ---RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK 2045
Query: 477 TTEAEKQELENQRVLKEQALQEAMEQ----LEQLELERKQALEQYEEVKKKLEMATNKTK 532
+AE++ KEQ LQ+ ++Q L+QL E + A EE ++ A +
Sbjct: 2046 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAA 2105
Query: 533 SWKDKVAHHEGL 544
+ +V E L
Sbjct: 2106 QSRRQVEEAERL 2117
Score = 54.7 bits (130), Expect = 2e-07
Identities = 68/237 (28%), Positives = 116/237 (48%), Gaps = 44/237 (18%)
Query: 322 RRKELRKKQLAEQEEL-ERQMKE-LQAANESKQQELEAV----RKKLEEAASRAAEEEKK 375
R ++L ++ LA+Q L E+ +KE +QA E+ + + EA +K+L + +R +E+K+
Sbjct: 2292 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2351
Query: 376 RLQTQVELQAR-FSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALE 434
++ Q+ + + F LE E+ ++Q+E S+E E+ RV E+ + +E +
Sbjct: 2352 QMAQQLAEETQGFQRTLEAER--QRQLE-----MSAEAERLKLRVAEMSRAQARAEE--D 2402
Query: 435 DERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQ----------AIQTTEAEKQE 484
+R +Q EE KL L + K ++ +++QQ AI E EK++
Sbjct: 2403 AQRFRKQAEEIGEKLHRTELATQE-KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK 2461
Query: 485 L------------ENQRVLKEQALQEAMEQLEQLELERKQALEQ----YEEVKKKLE 525
L E Q V +EQ LQE + L+Q L K +L Q E+ K KLE
Sbjct: 2462 LQQEAKLLQLKSEEMQTVQQEQLLQET-QALQQSFLSEKDSLLQRERFIEQEKAKLE 2517
Score = 53.9 bits (128), Expect = 4e-07
Identities = 69/282 (24%), Positives = 128/282 (45%), Gaps = 52/282 (18%)
Query: 321 QRRKELRKKQLAEQEELERQMKELQAANESKQ--------QELEAVRKKLEEAASRAAEE 372
+R +E + E+E+L+++ K LQ +E Q QE +A+++ +
Sbjct: 2446 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2505
Query: 373 EKKRLQTQVELQARFSTEL-------EREKLIRQQMEEQVAQKSSELEQYLQRVRELEDM 425
E+ Q + +L+ F E+ E ++ +QQME++ + + +E+ +R E E+
Sbjct: 2506 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2565
Query: 426 YLKLQEALED-ERQARQDEETVRKLQARLLEE----ESSKRAEL---EKWHLEQQQAIQT 477
+ QE L+ E+Q RQ EE + + RL E+ E RA L E+ Q A +T
Sbjct: 2566 VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2625
Query: 478 TEAEKQELEN--------------QRVLKEQALQEA----MEQLEQL--------ELERK 511
+ L+ +R + Q LQEA E+L++L EL R+
Sbjct: 2626 LPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARR 2685
Query: 512 QALEQYEEVKKKLEMATNKTKSWKDKVAHHEGLIR-LIEPGS 552
+ + Y ++ + +A K+ +K++ + L R L+ PG+
Sbjct: 2686 EDVRHY--LQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGT 2725
Score = 51.2 bits (121), Expect = 3e-06
Identities = 55/215 (25%), Positives = 100/215 (46%), Gaps = 14/215 (6%)
Query: 322 RRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEE--AASRAAEEEKKRLQT 379
R K+ ++ L E+ E +Q+ E A QE +R+ EE A RA E+ + +
Sbjct: 2257 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2316
Query: 380 QVELQARFSTELEREKLIRQQMEEQVAQKSSEL-EQYLQRVRELEDMYLKLQEALEDERQ 438
Q +A T L+ E + QQ +E +++ L E Q ++L + Q LE ERQ
Sbjct: 2317 QAVQEA---TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2373
Query: 439 ARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQE 498
RQ E + + +L + AE+ + ++ Q + +E+ + E A QE
Sbjct: 2374 -RQLEMSAEAERLKL------RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE 2426
Query: 499 AMEQLEQLELERKQALEQYEEVKKKL-EMATNKTK 532
+ ++ LE++R+Q+ E +++ + E+ K K
Sbjct: 2427 KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK 2461
Score = 48.9 bits (115), Expect = 1e-05
Identities = 48/198 (24%), Positives = 87/198 (43%), Gaps = 2/198 (1%)
Query: 342 KELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQM 401
+E+ A+E + +E +AV L E A + K+L+ Q E Q L E Q++
Sbjct: 1102 EEVLRAHEEQLKEAQAVPATLPEL--EATKASLKKLRAQAEAQQPTFDALRDELRGAQEV 1159
Query: 402 EEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKR 461
E++ Q+ E + ++R RE L+ +A+ + RQ E Q R E +
Sbjct: 1160 GERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPL 1219
Query: 462 AELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVK 521
+ +Q+ IQ + +++ +EQAL E +E+ + E ++ +QY
Sbjct: 1220 GAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAI 1279
Query: 522 KKLEMATNKTKSWKDKVA 539
K E+ K+ + VA
Sbjct: 1280 KDYELQLVTYKAQLEPVA 1297
Score = 35.4 bits (80), Expect = 0.15
Identities = 38/145 (26%), Positives = 63/145 (43%), Gaps = 21/145 (14%)
Query: 323 RKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVE 382
+KE + E E E+++KELQ A + +E R +E Q
Sbjct: 654 KKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESF--------------QAA 699
Query: 383 LQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQD 442
LQ ++S L+ I ++E A Q+ VRE E KLQEAL + +
Sbjct: 700 LQTQWSWMLQLCCCIEAHLKENAAYF-----QFFSDVREAEGQLQKLQEALR-RKYSCDR 753
Query: 443 EETVRKLQARLLEEESSKRAELEKW 467
TV +L+ LL++ ++ +L ++
Sbjct: 754 SATVTRLE-DLLQDAQDEKEQLNEY 777
Score = 30.4 bits (67), Expect = 4.7
Identities = 52/219 (23%), Positives = 85/219 (38%), Gaps = 23/219 (10%)
Query: 311 GSPPPHKEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAA 370
G P + E +QR R QL L K +A E EL+A +
Sbjct: 3187 GEPATYGELQQR---CRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEVPV 3243
Query: 371 EEEKKRLQTQVEL-QARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKL 429
K R T EL + + T +R++L+RQ +V +E + L
Sbjct: 3244 GGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVT---------------VEKVIKIL 3288
Query: 430 QEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQR 489
+E+ RQ+ + L+A + E L + EQ + +TT + EL + R
Sbjct: 3289 ITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVR 3348
Query: 490 VLKEQALQEAMEQLEQLELERKQALEQYEEVKKKLEMAT 528
L + + A LE + K+ + YE +++ L AT
Sbjct: 3349 TLLQGSGCLAGIYLE----DTKEKVSIYEAMRRGLLRAT 3383
Score = 30.4 bits (67), Expect = 4.7
Identities = 23/92 (25%), Positives = 44/92 (47%), Gaps = 5/92 (5%)
Query: 438 QARQDEETVRKLQARLLEEE---SSKRAELEKWHLEQQQAIQTTEAEKQELENQ--RVLK 492
Q +EET R + ++ S + + W + Q I + + + Q RV K
Sbjct: 3556 QVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTK 3615
Query: 493 EQALQEAMEQLEQLELERKQALEQYEEVKKKL 524
E+ + +E +E+ E+ R+Q L Y+ V+++L
Sbjct: 3616 ERMIIIIIEIIEKTEIIRQQGLASYDYVRRRL 3647
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 77.4 bits (189), Expect = 3e-14
Identities = 65/230 (28%), Positives = 116/230 (50%), Gaps = 16/230 (6%)
Query: 317 KEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKR 376
K+A + ++L + +LA QE++ ++ L+ + + E +R+ + E E EK++
Sbjct: 2376 KQAEEIGEKLHRTELATQEKVTL-VQTLEIQRQQSDHDAERLREAIAEL-----EREKEK 2429
Query: 377 LQTQVELQARFSTELEREKLIRQQMEEQVAQKS--SELEQYLQRVRELEDMYLKLQEALE 434
LQ + +L S E++ + + E Q Q+S SE + LQR R +E KL++ +
Sbjct: 2430 LQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQ 2489
Query: 435 DE-RQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQA---IQTTEAEKQELENQRV 490
DE +A+Q E ++ Q ++ +E A +E+ Q +A ++ + E Q+LE QR
Sbjct: 2490 DEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRR 2549
Query: 491 LKEQAL----QEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSWKD 536
+E+ L Q EQL+ LE + + AL EEV AT + +D
Sbjct: 2550 QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRD 2599
Score = 73.6 bits (179), Expect = 5e-13
Identities = 66/236 (27%), Positives = 113/236 (47%), Gaps = 31/236 (13%)
Query: 320 RQRRKELRKKQLAEQEELERQMKELQAANESKQ--QELEAVRKKLEEAASRAAEEEKKRL 377
RQ + E ++K+ AE E R E +AA E ++ Q LE +R + EEA R + E +R
Sbjct: 1469 RQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1528
Query: 378 Q------------TQVELQARFSTELEREKLIRQQMEEQ---VAQKSSELEQYLQRV--- 419
+ + ELQ++ ++ E+ + + ++E+ VAQ E E+ Q+
Sbjct: 1529 RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1588
Query: 420 --------RELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQ 471
RELE LK EAL QA + + QA +++ E + +
Sbjct: 1589 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1648
Query: 472 QQAIQTTEAEKQELENQRVLKEQALQE---AMEQLEQLELERKQALEQYEEVKKKL 524
+QA++ E +QELE QR L E Q+ A ++L +L E +Q +Q + ++++L
Sbjct: 1649 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1704
Score = 73.2 bits (178), Expect = 6e-13
Identities = 76/285 (26%), Positives = 140/285 (49%), Gaps = 50/285 (17%)
Query: 287 SASDKKKKQEW---IQAIHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQ---EELERQ 340
+A+ +K+QE + + + + +L +E+R ++ +++ AE EL +
Sbjct: 1711 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1770
Query: 341 MKELQA-ANESKQQELEAVRKKLEEAASRAAEEEK------------KRLQTQVELQARF 387
L+A A E+K+Q A E+AA + AE E+ RL+T+ E+ +
Sbjct: 1771 AARLRALAEEAKRQRQLAE----EDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK- 1825
Query: 388 STELEREKL---------IRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDE-- 436
E E E+L R+++EEQ AQ +++E+ L ++R+ D L+ Q+ L ++
Sbjct: 1826 EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTL 1885
Query: 437 RQARQDEETVRKLQARLLEEESSKRAELE----KWHLEQQQAIQTTEAEKQELENQRVL- 491
RQ RQ EE + L+A E+ ++ +AELE + + +++ E + E QR L
Sbjct: 1886 RQRRQVEEEILALKAS-FEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 1944
Query: 492 ---------KEQALQEAMEQLEQLELERKQALEQYEEVKKKLEMA 527
E+ +Q+++ E+ +RK ALE+ E +K K+E A
Sbjct: 1945 AEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 1989
Score = 70.9 bits (172), Expect = 3e-12
Identities = 69/264 (26%), Positives = 130/264 (49%), Gaps = 15/264 (5%)
Query: 291 KKKKQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQEELERQMKELQAA--N 348
+++ + W + + L +++ + + ++K+ AE+E R E QA
Sbjct: 1596 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1655
Query: 349 ESKQQELEAVRKKLEEAASR--AAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVA 406
E +QELE R+ E A + AAE+E RL+ + E Q +L E+L R Q E A
Sbjct: 1656 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE-QGEQQRQLLEEELARLQREAAAA 1714
Query: 407 -QKSSELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQA-----RLLEEESSK 460
QK ELE L +VR ++ L + E+E ++ E++ ++L+A R L EE+++
Sbjct: 1715 TQKRQELEAELAKVRAEMEVLLASKARAEEESRS-TSEKSKQRLEAEAGRFRELAEEAAR 1773
Query: 461 RAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQ--ALQEAMEQLEQLELERKQALEQYE 518
L + ++Q+ + +A +Q E +RVL E+ A+ EA + E+ K+ + E
Sbjct: 1774 LRALAE-EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE 1832
Query: 519 EVKKKLEMATNKTKSWKDKVAHHE 542
+++ E + + +++ A H+
Sbjct: 1833 RLRRLAEDEAFQRRRLEEQAAQHK 1856
Score = 70.9 bits (172), Expect = 3e-12
Identities = 61/272 (22%), Positives = 127/272 (46%), Gaps = 30/272 (11%)
Query: 285 EISASDKKKKQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRK-----------KQLAE 333
+++A ++++++E + + ++ + ARQR+ L + ++L E
Sbjct: 1942 QLAAEEERRRREAEERVQKSL-------AAEEEAARQRKAALEEVERLKAKVEEARRLRE 1994
Query: 334 QEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTELER 393
+ E E ++LQ A E+ Q+ L+A K A + +E ++ LQ + + + E E
Sbjct: 1995 RAEQE-SARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA 2053
Query: 394 EKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARL 453
+ ++ EE Q E Q ++V E E +L+++ E++ QAR + + +
Sbjct: 2054 ARRAAEEAEEARVQAEREAAQSRRQVEEAE----RLKQSAEEQAQARAQAQAAAEKLRKE 2109
Query: 454 LEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQA 513
E+E+++RA+ E+ L Q+QA E+E + EQ L++ + ++L R Q
Sbjct: 2110 AEQEAARRAQAEQAALRQKQAADA------EMEKHKKFAEQTLRQKAQVEQELTTLRLQ- 2162
Query: 514 LEQYEEVKKKLEMATNKTKSWKDKVAHHEGLI 545
LE+ + K L+ + K+ + A +
Sbjct: 2163 LEETDHQKNLLDEELQRLKAEATEAARQRSQV 2194
Score = 68.9 bits (167), Expect = 1e-11
Identities = 63/228 (27%), Positives = 114/228 (50%), Gaps = 35/228 (15%)
Query: 320 RQRRKELRKKQLAEQEELERQMKELQAANESKQQ-----------ELEAVRKK------L 362
R R +E ++ QEE ER +++Q ++ K+Q E EA R+K L
Sbjct: 1447 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1506
Query: 363 EEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVREL 422
EE +A E E++ Q +VE + LE + R E ++++S E+ Q R L
Sbjct: 1507 EELRLQAEEAERRLRQAEVERARQVQVALETAQ--RSAEAELQSKRASFAEKTAQLERSL 1564
Query: 423 EDMYLKLQEALED-ERQARQD-------EETVRKLQARLLEEESSKRAELEKWHLEQQQA 474
++ ++ + + E+ ER+A+Q EE R+L+ L+ + R L+ + QQ++
Sbjct: 1565 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS 1624
Query: 475 IQTTEAEKQELENQRVLK------EQALQEAMEQLEQLELERKQALEQ 516
+ EAEKQ+ E +R + EQA+++ +L + ELE+++ L +
Sbjct: 1625 LAQAEAEKQKEEAEREARRRGKAEEQAVRQ--RELAEQELEKQRQLAE 1670
Score = 68.9 bits (167), Expect = 1e-11
Identities = 73/244 (29%), Positives = 118/244 (48%), Gaps = 25/244 (10%)
Query: 308 LKLGSPPPHKEARQRRKE------LRKKQLAEQEELERQMKELQAANESKQQELEAVRKK 361
L+LG + E R KE R++QLA +EE R+ E + +S E EA R++
Sbjct: 1914 LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE-ERVQKSLAAEEEAARQR 1972
Query: 362 ---LEEAAS-RAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQ------VAQKSSE 411
LEE +A EE +RL+ + E ++ +L +E ++ E+ V QK E
Sbjct: 1973 KAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE 2032
Query: 412 LEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQ 471
L+Q LQ+ + + D +L+ E R+A ++ E R +QA E + R ++E+ +
Sbjct: 2033 LQQTLQQEQSVLD---QLRGEAEAARRAAEEAEEAR-VQAE--REAAQSRRQVEEAERLK 2086
Query: 472 QQAIQTTEAEKQELENQRVLKEQALQEAME--QLEQLELERKQALEQYEEVKKKLEMATN 529
Q A + +A Q L+++A QEA Q EQ L +KQA + E KK T
Sbjct: 2087 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2146
Query: 530 KTKS 533
+ K+
Sbjct: 2147 RQKA 2150
Score = 65.9 bits (159), Expect = 1e-10
Identities = 82/296 (27%), Positives = 136/296 (45%), Gaps = 29/296 (9%)
Query: 317 KEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKR 376
+ A+Q+ + R ++ AE+E Q+K +A Q E A +K L +A + +EE +R
Sbjct: 1580 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1639
Query: 377 ---LQTQVELQARFSTELEREKLIRQ-QMEEQVAQKSSELEQYLQRVRELEDMYLKLQEA 432
+ + E QA EL ++L +Q Q+ E AQ+ EQ L R+R + + ++
Sbjct: 1640 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1699
Query: 433 LEDERQARQDEETVRKLQARLLEEESSK-RAELEKWHLEQQQAIQ----TTEAEKQELEN 487
LE+E Q E + + LE E +K RAE+E + +A + T+E KQ LE
Sbjct: 1700 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1759
Query: 488 Q----RVLKEQALQ---EAMEQLEQLELERKQALEQYEEVKKKL-----------EMATN 529
+ R L E+A + A E Q +L + A Q E ++ L + T
Sbjct: 1760 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE 1819
Query: 530 KTKSWKDKVAHHEGLIRLIEPGSKNPHLITNWGPAAFTEAELEEREKNWKEKKTTE 585
+ K+K A +E L RL E + + AA +A++EER ++ +E
Sbjct: 1820 AEIALKEKEAENERLRRLAEDEAFQRRRLEE--QAAQHKADIEERLAQLRKASDSE 1873
Score = 63.5 bits (153), Expect = 5e-10
Identities = 55/211 (26%), Positives = 100/211 (47%), Gaps = 23/211 (10%)
Query: 328 KKQLAEQEELERQMKELQAANES-----KQQELEAVRKKLEEAASRAAEEEKKRLQTQVE 382
+K A + ELE ++ +++ E +Q ELEA R++ AAEEE++R + +
Sbjct: 1903 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR-----QLAAEEERRRREAEER 1957
Query: 383 LQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQD 442
+Q + E EE Q+ + LE+ ++R++ + +L+E E E ARQ
Sbjct: 1958 VQKSLAAE-----------EEAARQRKAALEE-VERLKAKVEEARRLRERAEQE-SARQL 2004
Query: 443 EETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQ 502
+ Q RL EE + +++ E QQ +Q ++ +L + +A +EA E
Sbjct: 2005 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2064
Query: 503 LEQLELERKQALEQYEEVKKKLEMATNKTKS 533
Q E E Q+ Q EE ++ + A + ++
Sbjct: 2065 RVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2095
Score = 62.0 bits (149), Expect = 1e-09
Identities = 54/212 (25%), Positives = 111/212 (52%), Gaps = 16/212 (7%)
Query: 317 KEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEE-EKK 375
+EA Q+R + +K A ++++ +ELQ + +Q L+ +R + E AA RAAEE E+
Sbjct: 2008 QEAAQKRLQAEEK--AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE-AARRAAEEAEEA 2064
Query: 376 RLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALED 435
R+Q + E A+ ++E + ++Q EEQ AQ ++ + +++R+ + E
Sbjct: 2065 RVQAERE-AAQSRRQVEEAERLKQSAEEQ-AQARAQAQAAAEKLRK--------EAEQEA 2114
Query: 436 ERQARQDEETVRKLQARLLEEESSKR--AELEKWHLEQQQAIQTTEAEKQELENQRVLKE 493
R+A+ ++ +R+ QA E E K+ + + + +Q + T + +E ++Q+ L +
Sbjct: 2115 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2174
Query: 494 QALQEAMEQLEQLELERKQALEQYEEVKKKLE 525
+ LQ + + +R Q E+ V+ ++E
Sbjct: 2175 EELQRLKAEATEAARQRSQVEEELFSVRVQME 2206
Score = 62.0 bits (149), Expect = 1e-09
Identities = 61/249 (24%), Positives = 119/249 (47%), Gaps = 43/249 (17%)
Query: 317 KEAR---QRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEE 373
+EAR +R ++Q+ E E L++ +E A Q E +RK+ E+ A+R A+ E
Sbjct: 2062 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2121
Query: 374 KKRLQ------TQVELQARFSTELEREKL--------IRQQMEEQVAQKSSELEQYLQRV 419
+ L+ ++E +F+ + R+K +R Q+EE QK+ L++ LQR+
Sbjct: 2122 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL-LDEELQRL 2180
Query: 420 RELEDMYLKLQEALEDER-QARQDEETVRKLQARL------------------LEEESSK 460
+ + + +E+E R E + KL+AR+ L+EE+ K
Sbjct: 2181 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2240
Query: 461 RA----ELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQA--L 514
E + + Q+A + + +++L QR L E+ L+E M+ +++ + +A L
Sbjct: 2241 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2300
Query: 515 EQYEEVKKK 523
+Q +E+ ++
Sbjct: 2301 QQQKELAQE 2309
Score = 59.7 bits (143), Expect = 7e-09
Identities = 70/267 (26%), Positives = 111/267 (41%), Gaps = 17/267 (6%)
Query: 318 EARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRL 377
+A + KEL+++ E E + Q S Q+EL+ +R+ E AE + K
Sbjct: 1353 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE------AEIQAKAR 1406
Query: 378 QTQVELQARFSTELEREKLIRQQMEEQVAQKSS---ELEQYLQRVRELEDMYLKLQEALE 434
Q + ++R E E +++R Q+E Q+ EL+ R E E + QE E
Sbjct: 1407 QAEAAERSRLRIE-EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1465
Query: 435 DERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQ 494
R+ QD E+ RK QA +E S +AE E E+Q+A+Q E + + E Q
Sbjct: 1466 RLRRQVQD-ESQRKRQAE-VELASRVKAEAEAAR-EKQRALQALEELRLQAEEAERRLRQ 1522
Query: 495 ALQEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSWKDKVAHHEGLIRLIEPGSKN 554
A E Q+ Q+ LE Q + E K+ A + + H + +L E +
Sbjct: 1523 AEVERARQV-QVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1581
Query: 555 PHLITNWGPAAFTEAELEEREKNWKEK 581
A E E + W+ K
Sbjct: 1582 AQ---QQAEAERAREEAERELERWQLK 1605
Score = 59.3 bits (142), Expect = 9e-09
Identities = 49/217 (22%), Positives = 105/217 (48%), Gaps = 19/217 (8%)
Query: 331 LAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTE 390
L EE ER ++ +A + E+EA +K + A A+ + + + ELQ R E
Sbjct: 1309 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1368
Query: 391 LEREKLIRQQMEEQVAQKSSELEQYLQRVRELE--DMYLKLQEALEDERQARQDEETVRK 448
+ R R++ Q+ +++ LQ++R+ ++ K ++A ER + EE +R
Sbjct: 1369 VVR----REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1424
Query: 449 LQARLLEEESSK----------RAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQE 498
++ +L E + RA E+ +++QA + E +++++++ K QA E
Sbjct: 1425 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1484
Query: 499 AMEQLE---QLELERKQALEQYEEVKKKLEMATNKTK 532
+++ + E+++AL+ EE++ + E A + +
Sbjct: 1485 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR 1521
Score = 59.3 bits (142), Expect = 9e-09
Identities = 65/229 (28%), Positives = 123/229 (53%), Gaps = 34/229 (14%)
Query: 319 ARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAA------SRAAEE 372
A +++++L + + + ER+ KELQ ++ + E VR+ EEAA R+ +E
Sbjct: 1336 ALEKQRQLAEAHAQAKAQAEREAKELQ-----QRMQEEVVRR--EEAAVDAQQQKRSIQE 1388
Query: 373 EKKRLQ--TQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVR-----ELEDM 425
E ++L+ ++ E+QA+ + + E + R ++EE++ +LE +R R EL+ +
Sbjct: 1389 ELQQLRQSSEAEIQAK-ARQAEAAERSRLRIEEEIRVVRLQLEA-TERQRGGAEGELQAL 1446
Query: 426 YLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQEL 485
+ +EA +RQA+++ E +R R +++ES ++ + E +E ++ EAE
Sbjct: 1447 RARAEEAEAQKRQAQEEAERLR----RQVQDESQRKRQAE---VELASRVK-AEAEAAR- 1497
Query: 486 ENQRVLKEQALQEAMEQLEQLELERKQA-LEQYEEVKKKLEMATNKTKS 533
E QR L QAL+E Q E+ E +QA +E+ +V+ LE A ++
Sbjct: 1498 EKQRAL--QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1544
Score = 58.5 bits (140), Expect = 2e-08
Identities = 55/241 (22%), Positives = 107/241 (44%), Gaps = 13/241 (5%)
Query: 299 QAIHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQE--ELERQMKELQAANESKQQELE 356
QA + + + K + + LR+K EQE L Q++E +EL+
Sbjct: 2119 QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2178
Query: 357 AVRKKLEEAASRAAEEEKKRLQTQVELQ----ARFSTELEREKLIRQQMEEQVAQKSSEL 412
++ + EAA + ++ E++ +V+++ + E E LI + + E
Sbjct: 2179 RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEA 2238
Query: 413 EQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEE-----ESSKRAELEKW 467
E+ Q E + + QEA + A +D R L ++L+E + + R + E
Sbjct: 2239 EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE 2298
Query: 468 HLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVKK-KLEM 526
L+QQ+ + +A + + E++ + +Q +E LE ER++ LE E ++ KL +
Sbjct: 2299 LLQQQKELAQEQARRLQ-EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRV 2357
Query: 527 A 527
A
Sbjct: 2358 A 2358
Score = 58.2 bits (139), Expect = 2e-08
Identities = 53/204 (25%), Positives = 97/204 (47%), Gaps = 13/204 (6%)
Query: 335 EELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTELERE 394
E L R +E + A + + +E R++L E A EK+R + QA+ E E +
Sbjct: 1307 ETLRRMEEEERLAEQQRAEE----RERLAEVE---AALEKQRQLAEAHAQAKAQAEREAK 1359
Query: 395 KLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQAR-QDEETVRKLQARL 453
+L +Q+M+E+V ++ Q+ R +++ +L+++ E E QA+ + E + + R+
Sbjct: 1360 EL-QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1418
Query: 454 LEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELE---- 509
EE R +LE ++ A +A + E K QA +EA Q++ E
Sbjct: 1419 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1478
Query: 510 RKQALEQYEEVKKKLEMATNKTKS 533
R+ +E VK + E A K ++
Sbjct: 1479 RQAEVELASRVKAEAEAAREKQRA 1502
Score = 55.8 bits (133), Expect = 1e-07
Identities = 48/235 (20%), Positives = 109/235 (46%), Gaps = 15/235 (6%)
Query: 290 DKKKKQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQEELERQMKELQAANE 349
D +++QE IQA+ P +++ R++LR++Q A EE+ER ++++
Sbjct: 1193 DARRRQEQIQAM-------------PLADSQAVREQLRQEQ-ALLEEIERHGEKVEECQR 1238
Query: 350 SKQQELEAVRK-KLEEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQK 408
+Q + A++ +L+ +A E + ++Q+ + ++ +R E
Sbjct: 1239 FAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLT 1298
Query: 409 SSELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWH 468
S ++ + +R +E+ ++ +ER+ + E + Q +L E + +A+ E+
Sbjct: 1299 SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA 1358
Query: 469 LEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVKKK 523
E QQ +Q ++E +++++QE ++QL Q QA + E ++
Sbjct: 1359 KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1413
Score = 55.5 bits (132), Expect = 1e-07
Identities = 69/252 (27%), Positives = 118/252 (46%), Gaps = 32/252 (12%)
Query: 318 EARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAAS--RAAEEEKK 375
EA QRR+ L ++ + ++E ++ +L+ A++S ELE + +E+ R EEE
Sbjct: 1841 EAFQRRR-LEEQAAQHKADIEERLAQLRKASDS---ELERQKGLVEDTLRQRRQVEEEIL 1896
Query: 376 RLQTQVELQARFSTELEREK-LIRQQMEEQVAQKS-SELEQYLQRV---------RELED 424
L+ E A ELE E IR E+ + K +ELE QR RE E+
Sbjct: 1897 ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 1956
Query: 425 MYLKLQEALEDERQARQDE----ETVRKLQARLLE----EESSKRAELEKWHLEQQQAIQ 476
++Q++L E +A + E V +L+A++ E E +++ + L Q+ A +
Sbjct: 1957 ---RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK 2013
Query: 477 TTEAEKQELENQRVLKEQALQEAMEQ----LEQLELERKQALEQYEEVKKKLEMATNKTK 532
+AE++ KEQ LQ+ ++Q L+QL E + A EE ++ A +
Sbjct: 2014 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAA 2073
Query: 533 SWKDKVAHHEGL 544
+ +V E L
Sbjct: 2074 QSRRQVEEAERL 2085
Score = 54.7 bits (130), Expect = 2e-07
Identities = 68/237 (28%), Positives = 116/237 (48%), Gaps = 44/237 (18%)
Query: 322 RRKELRKKQLAEQEEL-ERQMKE-LQAANESKQQELEAV----RKKLEEAASRAAEEEKK 375
R ++L ++ LA+Q L E+ +KE +QA E+ + + EA +K+L + +R +E+K+
Sbjct: 2260 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2319
Query: 376 RLQTQVELQAR-FSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALE 434
++ Q+ + + F LE E+ ++Q+E S+E E+ RV E+ + +E +
Sbjct: 2320 QMAQQLAEETQGFQRTLEAER--QRQLE-----MSAEAERLKLRVAEMSRAQARAEE--D 2370
Query: 435 DERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQ----------AIQTTEAEKQE 484
+R +Q EE KL L + K ++ +++QQ AI E EK++
Sbjct: 2371 AQRFRKQAEEIGEKLHRTELATQE-KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK 2429
Query: 485 L------------ENQRVLKEQALQEAMEQLEQLELERKQALEQ----YEEVKKKLE 525
L E Q V +EQ LQE + L+Q L K +L Q E+ K KLE
Sbjct: 2430 LQQEAKLLQLKSEEMQTVQQEQLLQET-QALQQSFLSEKDSLLQRERFIEQEKAKLE 2485
Score = 53.9 bits (128), Expect = 4e-07
Identities = 69/282 (24%), Positives = 128/282 (45%), Gaps = 52/282 (18%)
Query: 321 QRRKELRKKQLAEQEELERQMKELQAANESKQ--------QELEAVRKKLEEAASRAAEE 372
+R +E + E+E+L+++ K LQ +E Q QE +A+++ +
Sbjct: 2414 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2473
Query: 373 EKKRLQTQVELQARFSTEL-------EREKLIRQQMEEQVAQKSSELEQYLQRVRELEDM 425
E+ Q + +L+ F E+ E ++ +QQME++ + + +E+ +R E E+
Sbjct: 2474 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2533
Query: 426 YLKLQEALED-ERQARQDEETVRKLQARLLEE----ESSKRAEL---EKWHLEQQQAIQT 477
+ QE L+ E+Q RQ EE + + RL E+ E RA L E+ Q A +T
Sbjct: 2534 VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2593
Query: 478 TEAEKQELEN--------------QRVLKEQALQEA----MEQLEQL--------ELERK 511
+ L+ +R + Q LQEA E+L++L EL R+
Sbjct: 2594 LPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARR 2653
Query: 512 QALEQYEEVKKKLEMATNKTKSWKDKVAHHEGLIR-LIEPGS 552
+ + Y ++ + +A K+ +K++ + L R L+ PG+
Sbjct: 2654 EDVRHY--LQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGT 2693
Score = 51.2 bits (121), Expect = 3e-06
Identities = 55/215 (25%), Positives = 100/215 (46%), Gaps = 14/215 (6%)
Query: 322 RRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEE--AASRAAEEEKKRLQT 379
R K+ ++ L E+ E +Q+ E A QE +R+ EE A RA E+ + +
Sbjct: 2225 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2284
Query: 380 QVELQARFSTELEREKLIRQQMEEQVAQKSSEL-EQYLQRVRELEDMYLKLQEALEDERQ 438
Q +A T L+ E + QQ +E +++ L E Q ++L + Q LE ERQ
Sbjct: 2285 QAVQEA---TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2341
Query: 439 ARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQE 498
RQ E + + +L + AE+ + ++ Q + +E+ + E A QE
Sbjct: 2342 -RQLEMSAEAERLKL------RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE 2394
Query: 499 AMEQLEQLELERKQALEQYEEVKKKL-EMATNKTK 532
+ ++ LE++R+Q+ E +++ + E+ K K
Sbjct: 2395 KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK 2429
Score = 48.9 bits (115), Expect = 1e-05
Identities = 48/198 (24%), Positives = 87/198 (43%), Gaps = 2/198 (1%)
Query: 342 KELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQM 401
+E+ A+E + +E +AV L E A + K+L+ Q E Q L E Q++
Sbjct: 1070 EEVLRAHEEQLKEAQAVPATLPEL--EATKASLKKLRAQAEAQQPTFDALRDELRGAQEV 1127
Query: 402 EEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKR 461
E++ Q+ E + ++R RE L+ +A+ + RQ E Q R E +
Sbjct: 1128 GERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPL 1187
Query: 462 AELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVK 521
+ +Q+ IQ + +++ +EQAL E +E+ + E ++ +QY
Sbjct: 1188 GAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAI 1247
Query: 522 KKLEMATNKTKSWKDKVA 539
K E+ K+ + VA
Sbjct: 1248 KDYELQLVTYKAQLEPVA 1265
Score = 35.4 bits (80), Expect = 0.15
Identities = 38/145 (26%), Positives = 63/145 (43%), Gaps = 21/145 (14%)
Query: 323 RKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVE 382
+KE + E E E+++KELQ A + +E R +E Q
Sbjct: 622 KKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESF--------------QAA 667
Query: 383 LQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQD 442
LQ ++S L+ I ++E A Q+ VRE E KLQEAL + +
Sbjct: 668 LQTQWSWMLQLCCCIEAHLKENAAYF-----QFFSDVREAEGQLQKLQEALR-RKYSCDR 721
Query: 443 EETVRKLQARLLEEESSKRAELEKW 467
TV +L+ LL++ ++ +L ++
Sbjct: 722 SATVTRLE-DLLQDAQDEKEQLNEY 745
Score = 30.4 bits (67), Expect = 4.7
Identities = 52/219 (23%), Positives = 85/219 (38%), Gaps = 23/219 (10%)
Query: 311 GSPPPHKEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAA 370
G P + E +QR R QL L K +A E EL+A +
Sbjct: 3155 GEPATYGELQQR---CRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEVPV 3211
Query: 371 EEEKKRLQTQVEL-QARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKL 429
K R T EL + + T +R++L+RQ +V +E + L
Sbjct: 3212 GGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVT---------------VEKVIKIL 3256
Query: 430 QEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQR 489
+E+ RQ+ + L+A + E L + EQ + +TT + EL + R
Sbjct: 3257 ITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVR 3316
Query: 490 VLKEQALQEAMEQLEQLELERKQALEQYEEVKKKLEMAT 528
L + + A LE + K+ + YE +++ L AT
Sbjct: 3317 TLLQGSGCLAGIYLE----DTKEKVSIYEAMRRGLLRAT 3351
Score = 30.4 bits (67), Expect = 4.7
Identities = 23/92 (25%), Positives = 44/92 (47%), Gaps = 5/92 (5%)
Query: 438 QARQDEETVRKLQARLLEEE---SSKRAELEKWHLEQQQAIQTTEAEKQELENQ--RVLK 492
Q +EET R + ++ S + + W + Q I + + + Q RV K
Sbjct: 3524 QVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTK 3583
Query: 493 EQALQEAMEQLEQLELERKQALEQYEEVKKKL 524
E+ + +E +E+ E+ R+Q L Y+ V+++L
Sbjct: 3584 ERMIIIIIEIIEKTEIIRQQGLASYDYVRRRL 3615
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 77.4 bits (189), Expect = 3e-14
Identities = 65/230 (28%), Positives = 116/230 (50%), Gaps = 16/230 (6%)
Query: 317 KEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKR 376
K+A + ++L + +LA QE++ ++ L+ + + E +R+ + E E EK++
Sbjct: 2545 KQAEEIGEKLHRTELATQEKVTL-VQTLEIQRQQSDHDAERLREAIAEL-----EREKEK 2598
Query: 377 LQTQVELQARFSTELEREKLIRQQMEEQVAQKS--SELEQYLQRVRELEDMYLKLQEALE 434
LQ + +L S E++ + + E Q Q+S SE + LQR R +E KL++ +
Sbjct: 2599 LQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQ 2658
Query: 435 DE-RQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQA---IQTTEAEKQELENQRV 490
DE +A+Q E ++ Q ++ +E A +E+ Q +A ++ + E Q+LE QR
Sbjct: 2659 DEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRR 2718
Query: 491 LKEQAL----QEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSWKD 536
+E+ L Q EQL+ LE + + AL EEV AT + +D
Sbjct: 2719 QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRD 2768
Score = 73.6 bits (179), Expect = 5e-13
Identities = 66/236 (27%), Positives = 113/236 (47%), Gaps = 31/236 (13%)
Query: 320 RQRRKELRKKQLAEQEELERQMKELQAANESKQ--QELEAVRKKLEEAASRAAEEEKKRL 377
RQ + E ++K+ AE E R E +AA E ++ Q LE +R + EEA R + E +R
Sbjct: 1638 RQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1697
Query: 378 Q------------TQVELQARFSTELEREKLIRQQMEEQ---VAQKSSELEQYLQRV--- 419
+ + ELQ++ ++ E+ + + ++E+ VAQ E E+ Q+
Sbjct: 1698 RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1757
Query: 420 --------RELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQ 471
RELE LK EAL QA + + QA +++ E + +
Sbjct: 1758 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1817
Query: 472 QQAIQTTEAEKQELENQRVLKEQALQE---AMEQLEQLELERKQALEQYEEVKKKL 524
+QA++ E +QELE QR L E Q+ A ++L +L E +Q +Q + ++++L
Sbjct: 1818 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1873
Score = 73.2 bits (178), Expect = 6e-13
Identities = 76/285 (26%), Positives = 140/285 (49%), Gaps = 50/285 (17%)
Query: 287 SASDKKKKQEW---IQAIHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQ---EELERQ 340
+A+ +K+QE + + + + +L +E+R ++ +++ AE EL +
Sbjct: 1880 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1939
Query: 341 MKELQA-ANESKQQELEAVRKKLEEAASRAAEEEK------------KRLQTQVELQARF 387
L+A A E+K+Q A E+AA + AE E+ RL+T+ E+ +
Sbjct: 1940 AARLRALAEEAKRQRQLAE----EDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK- 1994
Query: 388 STELEREKL---------IRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDE-- 436
E E E+L R+++EEQ AQ +++E+ L ++R+ D L+ Q+ L ++
Sbjct: 1995 EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTL 2054
Query: 437 RQARQDEETVRKLQARLLEEESSKRAELE----KWHLEQQQAIQTTEAEKQELENQRVL- 491
RQ RQ EE + L+A E+ ++ +AELE + + +++ E + E QR L
Sbjct: 2055 RQRRQVEEEILALKAS-FEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 2113
Query: 492 ---------KEQALQEAMEQLEQLELERKQALEQYEEVKKKLEMA 527
E+ +Q+++ E+ +RK ALE+ E +K K+E A
Sbjct: 2114 AEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2158
Score = 70.9 bits (172), Expect = 3e-12
Identities = 69/264 (26%), Positives = 130/264 (49%), Gaps = 15/264 (5%)
Query: 291 KKKKQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQEELERQMKELQAA--N 348
+++ + W + + L +++ + + ++K+ AE+E R E QA
Sbjct: 1765 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1824
Query: 349 ESKQQELEAVRKKLEEAASR--AAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVA 406
E +QELE R+ E A + AAE+E RL+ + E Q +L E+L R Q E A
Sbjct: 1825 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE-QGEQQRQLLEEELARLQREAAAA 1883
Query: 407 -QKSSELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQA-----RLLEEESSK 460
QK ELE L +VR ++ L + E+E ++ E++ ++L+A R L EE+++
Sbjct: 1884 TQKRQELEAELAKVRAEMEVLLASKARAEEESRS-TSEKSKQRLEAEAGRFRELAEEAAR 1942
Query: 461 RAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQ--ALQEAMEQLEQLELERKQALEQYE 518
L + ++Q+ + +A +Q E +RVL E+ A+ EA + E+ K+ + E
Sbjct: 1943 LRALAE-EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE 2001
Query: 519 EVKKKLEMATNKTKSWKDKVAHHE 542
+++ E + + +++ A H+
Sbjct: 2002 RLRRLAEDEAFQRRRLEEQAAQHK 2025
Score = 70.9 bits (172), Expect = 3e-12
Identities = 61/272 (22%), Positives = 127/272 (46%), Gaps = 30/272 (11%)
Query: 285 EISASDKKKKQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRK-----------KQLAE 333
+++A ++++++E + + ++ + ARQR+ L + ++L E
Sbjct: 2111 QLAAEEERRRREAEERVQKSL-------AAEEEAARQRKAALEEVERLKAKVEEARRLRE 2163
Query: 334 QEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTELER 393
+ E E ++LQ A E+ Q+ L+A K A + +E ++ LQ + + + E E
Sbjct: 2164 RAEQE-SARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA 2222
Query: 394 EKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARL 453
+ ++ EE Q E Q ++V E E +L+++ E++ QAR + + +
Sbjct: 2223 ARRAAEEAEEARVQAEREAAQSRRQVEEAE----RLKQSAEEQAQARAQAQAAAEKLRKE 2278
Query: 454 LEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQA 513
E+E+++RA+ E+ L Q+QA E+E + EQ L++ + ++L R Q
Sbjct: 2279 AEQEAARRAQAEQAALRQKQAADA------EMEKHKKFAEQTLRQKAQVEQELTTLRLQ- 2331
Query: 514 LEQYEEVKKKLEMATNKTKSWKDKVAHHEGLI 545
LE+ + K L+ + K+ + A +
Sbjct: 2332 LEETDHQKNLLDEELQRLKAEATEAARQRSQV 2363
Score = 68.9 bits (167), Expect = 1e-11
Identities = 63/228 (27%), Positives = 114/228 (50%), Gaps = 35/228 (15%)
Query: 320 RQRRKELRKKQLAEQEELERQMKELQAANESKQQ-----------ELEAVRKK------L 362
R R +E ++ QEE ER +++Q ++ K+Q E EA R+K L
Sbjct: 1616 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1675
Query: 363 EEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVREL 422
EE +A E E++ Q +VE + LE + R E ++++S E+ Q R L
Sbjct: 1676 EELRLQAEEAERRLRQAEVERARQVQVALETAQ--RSAEAELQSKRASFAEKTAQLERSL 1733
Query: 423 EDMYLKLQEALED-ERQARQD-------EETVRKLQARLLEEESSKRAELEKWHLEQQQA 474
++ ++ + + E+ ER+A+Q EE R+L+ L+ + R L+ + QQ++
Sbjct: 1734 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS 1793
Query: 475 IQTTEAEKQELENQRVLK------EQALQEAMEQLEQLELERKQALEQ 516
+ EAEKQ+ E +R + EQA+++ +L + ELE+++ L +
Sbjct: 1794 LAQAEAEKQKEEAEREARRRGKAEEQAVRQ--RELAEQELEKQRQLAE 1839
Score = 68.9 bits (167), Expect = 1e-11
Identities = 73/244 (29%), Positives = 118/244 (48%), Gaps = 25/244 (10%)
Query: 308 LKLGSPPPHKEARQRRKE------LRKKQLAEQEELERQMKELQAANESKQQELEAVRKK 361
L+LG + E R KE R++QLA +EE R+ E + +S E EA R++
Sbjct: 2083 LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE-ERVQKSLAAEEEAARQR 2141
Query: 362 ---LEEAAS-RAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQ------VAQKSSE 411
LEE +A EE +RL+ + E ++ +L +E ++ E+ V QK E
Sbjct: 2142 KAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE 2201
Query: 412 LEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQ 471
L+Q LQ+ + + D +L+ E R+A ++ E R +QA E + R ++E+ +
Sbjct: 2202 LQQTLQQEQSVLD---QLRGEAEAARRAAEEAEEAR-VQAE--REAAQSRRQVEEAERLK 2255
Query: 472 QQAIQTTEAEKQELENQRVLKEQALQEAME--QLEQLELERKQALEQYEEVKKKLEMATN 529
Q A + +A Q L+++A QEA Q EQ L +KQA + E KK T
Sbjct: 2256 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2315
Query: 530 KTKS 533
+ K+
Sbjct: 2316 RQKA 2319
Score = 65.9 bits (159), Expect = 1e-10
Identities = 82/296 (27%), Positives = 136/296 (45%), Gaps = 29/296 (9%)
Query: 317 KEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKR 376
+ A+Q+ + R ++ AE+E Q+K +A Q E A +K L +A + +EE +R
Sbjct: 1749 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1808
Query: 377 ---LQTQVELQARFSTELEREKLIRQ-QMEEQVAQKSSELEQYLQRVRELEDMYLKLQEA 432
+ + E QA EL ++L +Q Q+ E AQ+ EQ L R+R + + ++
Sbjct: 1809 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1868
Query: 433 LEDERQARQDEETVRKLQARLLEEESSK-RAELEKWHLEQQQAIQ----TTEAEKQELEN 487
LE+E Q E + + LE E +K RAE+E + +A + T+E KQ LE
Sbjct: 1869 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1928
Query: 488 Q----RVLKEQALQ---EAMEQLEQLELERKQALEQYEEVKKKL-----------EMATN 529
+ R L E+A + A E Q +L + A Q E ++ L + T
Sbjct: 1929 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE 1988
Query: 530 KTKSWKDKVAHHEGLIRLIEPGSKNPHLITNWGPAAFTEAELEEREKNWKEKKTTE 585
+ K+K A +E L RL E + + AA +A++EER ++ +E
Sbjct: 1989 AEIALKEKEAENERLRRLAEDEAFQRRRLEE--QAAQHKADIEERLAQLRKASDSE 2042
Score = 63.5 bits (153), Expect = 5e-10
Identities = 55/211 (26%), Positives = 100/211 (47%), Gaps = 23/211 (10%)
Query: 328 KKQLAEQEELERQMKELQAANES-----KQQELEAVRKKLEEAASRAAEEEKKRLQTQVE 382
+K A + ELE ++ +++ E +Q ELEA R++ AAEEE++R + +
Sbjct: 2072 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR-----QLAAEEERRRREAEER 2126
Query: 383 LQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQD 442
+Q + E EE Q+ + LE+ ++R++ + +L+E E E ARQ
Sbjct: 2127 VQKSLAAE-----------EEAARQRKAALEE-VERLKAKVEEARRLRERAEQE-SARQL 2173
Query: 443 EETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQ 502
+ Q RL EE + +++ E QQ +Q ++ +L + +A +EA E
Sbjct: 2174 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2233
Query: 503 LEQLELERKQALEQYEEVKKKLEMATNKTKS 533
Q E E Q+ Q EE ++ + A + ++
Sbjct: 2234 RVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2264
Score = 62.0 bits (149), Expect = 1e-09
Identities = 54/212 (25%), Positives = 111/212 (52%), Gaps = 16/212 (7%)
Query: 317 KEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEE-EKK 375
+EA Q+R + +K A ++++ +ELQ + +Q L+ +R + E AA RAAEE E+
Sbjct: 2177 QEAAQKRLQAEEK--AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE-AARRAAEEAEEA 2233
Query: 376 RLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALED 435
R+Q + E A+ ++E + ++Q EEQ AQ ++ + +++R+ + E
Sbjct: 2234 RVQAERE-AAQSRRQVEEAERLKQSAEEQ-AQARAQAQAAAEKLRK--------EAEQEA 2283
Query: 436 ERQARQDEETVRKLQARLLEEESSKR--AELEKWHLEQQQAIQTTEAEKQELENQRVLKE 493
R+A+ ++ +R+ QA E E K+ + + + +Q + T + +E ++Q+ L +
Sbjct: 2284 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2343
Query: 494 QALQEAMEQLEQLELERKQALEQYEEVKKKLE 525
+ LQ + + +R Q E+ V+ ++E
Sbjct: 2344 EELQRLKAEATEAARQRSQVEEELFSVRVQME 2375
Score = 62.0 bits (149), Expect = 1e-09
Identities = 61/249 (24%), Positives = 119/249 (47%), Gaps = 43/249 (17%)
Query: 317 KEAR---QRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEE 373
+EAR +R ++Q+ E E L++ +E A Q E +RK+ E+ A+R A+ E
Sbjct: 2231 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2290
Query: 374 KKRLQ------TQVELQARFSTELEREKL--------IRQQMEEQVAQKSSELEQYLQRV 419
+ L+ ++E +F+ + R+K +R Q+EE QK+ L++ LQR+
Sbjct: 2291 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL-LDEELQRL 2349
Query: 420 RELEDMYLKLQEALEDER-QARQDEETVRKLQARL------------------LEEESSK 460
+ + + +E+E R E + KL+AR+ L+EE+ K
Sbjct: 2350 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2409
Query: 461 RA----ELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQA--L 514
E + + Q+A + + +++L QR L E+ L+E M+ +++ + +A L
Sbjct: 2410 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2469
Query: 515 EQYEEVKKK 523
+Q +E+ ++
Sbjct: 2470 QQQKELAQE 2478
Score = 59.7 bits (143), Expect = 7e-09
Identities = 70/267 (26%), Positives = 111/267 (41%), Gaps = 17/267 (6%)
Query: 318 EARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRL 377
+A + KEL+++ E E + Q S Q+EL+ +R+ E AE + K
Sbjct: 1522 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE------AEIQAKAR 1575
Query: 378 QTQVELQARFSTELEREKLIRQQMEEQVAQKSS---ELEQYLQRVRELEDMYLKLQEALE 434
Q + ++R E E +++R Q+E Q+ EL+ R E E + QE E
Sbjct: 1576 QAEAAERSRLRIE-EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1634
Query: 435 DERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQ 494
R+ QD E+ RK QA +E S +AE E E+Q+A+Q E + + E Q
Sbjct: 1635 RLRRQVQD-ESQRKRQAE-VELASRVKAEAEAAR-EKQRALQALEELRLQAEEAERRLRQ 1691
Query: 495 ALQEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSWKDKVAHHEGLIRLIEPGSKN 554
A E Q+ Q+ LE Q + E K+ A + + H + +L E +
Sbjct: 1692 AEVERARQV-QVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1750
Query: 555 PHLITNWGPAAFTEAELEEREKNWKEK 581
A E E + W+ K
Sbjct: 1751 AQ---QQAEAERAREEAERELERWQLK 1774
Score = 59.3 bits (142), Expect = 9e-09
Identities = 49/217 (22%), Positives = 105/217 (48%), Gaps = 19/217 (8%)
Query: 331 LAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTE 390
L EE ER ++ +A + E+EA +K + A A+ + + + ELQ R E
Sbjct: 1478 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1537
Query: 391 LEREKLIRQQMEEQVAQKSSELEQYLQRVRELE--DMYLKLQEALEDERQARQDEETVRK 448
+ R R++ Q+ +++ LQ++R+ ++ K ++A ER + EE +R
Sbjct: 1538 VVR----REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1593
Query: 449 LQARLLEEESSK----------RAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQE 498
++ +L E + RA E+ +++QA + E +++++++ K QA E
Sbjct: 1594 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1653
Query: 499 AMEQLE---QLELERKQALEQYEEVKKKLEMATNKTK 532
+++ + E+++AL+ EE++ + E A + +
Sbjct: 1654 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR 1690
Score = 59.3 bits (142), Expect = 9e-09
Identities = 65/229 (28%), Positives = 123/229 (53%), Gaps = 34/229 (14%)
Query: 319 ARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAA------SRAAEE 372
A +++++L + + + ER+ KELQ ++ + E VR+ EEAA R+ +E
Sbjct: 1505 ALEKQRQLAEAHAQAKAQAEREAKELQ-----QRMQEEVVRR--EEAAVDAQQQKRSIQE 1557
Query: 373 EKKRLQ--TQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVR-----ELEDM 425
E ++L+ ++ E+QA+ + + E + R ++EE++ +LE +R R EL+ +
Sbjct: 1558 ELQQLRQSSEAEIQAK-ARQAEAAERSRLRIEEEIRVVRLQLEA-TERQRGGAEGELQAL 1615
Query: 426 YLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQEL 485
+ +EA +RQA+++ E +R R +++ES ++ + E +E ++ EAE
Sbjct: 1616 RARAEEAEAQKRQAQEEAERLR----RQVQDESQRKRQAE---VELASRVK-AEAEAAR- 1666
Query: 486 ENQRVLKEQALQEAMEQLEQLELERKQA-LEQYEEVKKKLEMATNKTKS 533
E QR L QAL+E Q E+ E +QA +E+ +V+ LE A ++
Sbjct: 1667 EKQRAL--QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1713
Score = 58.5 bits (140), Expect = 2e-08
Identities = 55/241 (22%), Positives = 107/241 (44%), Gaps = 13/241 (5%)
Query: 299 QAIHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQE--ELERQMKELQAANESKQQELE 356
QA + + + K + + LR+K EQE L Q++E +EL+
Sbjct: 2288 QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2347
Query: 357 AVRKKLEEAASRAAEEEKKRLQTQVELQ----ARFSTELEREKLIRQQMEEQVAQKSSEL 412
++ + EAA + ++ E++ +V+++ + E E LI + + E
Sbjct: 2348 RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEA 2407
Query: 413 EQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEE-----ESSKRAELEKW 467
E+ Q E + + QEA + A +D R L ++L+E + + R + E
Sbjct: 2408 EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE 2467
Query: 468 HLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVKK-KLEM 526
L+QQ+ + +A + + E++ + +Q +E LE ER++ LE E ++ KL +
Sbjct: 2468 LLQQQKELAQEQARRLQ-EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRV 2526
Query: 527 A 527
A
Sbjct: 2527 A 2527
Score = 58.2 bits (139), Expect = 2e-08
Identities = 53/204 (25%), Positives = 97/204 (47%), Gaps = 13/204 (6%)
Query: 335 EELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTELERE 394
E L R +E + A + + +E R++L E A EK+R + QA+ E E +
Sbjct: 1476 ETLRRMEEEERLAEQQRAEE----RERLAEVE---AALEKQRQLAEAHAQAKAQAEREAK 1528
Query: 395 KLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQAR-QDEETVRKLQARL 453
+L +Q+M+E+V ++ Q+ R +++ +L+++ E E QA+ + E + + R+
Sbjct: 1529 EL-QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1587
Query: 454 LEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELE---- 509
EE R +LE ++ A +A + E K QA +EA Q++ E
Sbjct: 1588 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1647
Query: 510 RKQALEQYEEVKKKLEMATNKTKS 533
R+ +E VK + E A K ++
Sbjct: 1648 RQAEVELASRVKAEAEAAREKQRA 1671
Score = 55.8 bits (133), Expect = 1e-07
Identities = 48/235 (20%), Positives = 109/235 (46%), Gaps = 15/235 (6%)
Query: 290 DKKKKQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQEELERQMKELQAANE 349
D +++QE IQA+ P +++ R++LR++Q A EE+ER ++++
Sbjct: 1362 DARRRQEQIQAM-------------PLADSQAVREQLRQEQ-ALLEEIERHGEKVEECQR 1407
Query: 350 SKQQELEAVRK-KLEEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQK 408
+Q + A++ +L+ +A E + ++Q+ + ++ +R E
Sbjct: 1408 FAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLT 1467
Query: 409 SSELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWH 468
S ++ + +R +E+ ++ +ER+ + E + Q +L E + +A+ E+
Sbjct: 1468 SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA 1527
Query: 469 LEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVKKK 523
E QQ +Q ++E +++++QE ++QL Q QA + E ++
Sbjct: 1528 KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1582
Score = 55.5 bits (132), Expect = 1e-07
Identities = 69/252 (27%), Positives = 118/252 (46%), Gaps = 32/252 (12%)
Query: 318 EARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAAS--RAAEEEKK 375
EA QRR+ L ++ + ++E ++ +L+ A++S ELE + +E+ R EEE
Sbjct: 2010 EAFQRRR-LEEQAAQHKADIEERLAQLRKASDS---ELERQKGLVEDTLRQRRQVEEEIL 2065
Query: 376 RLQTQVELQARFSTELEREK-LIRQQMEEQVAQKS-SELEQYLQRV---------RELED 424
L+ E A ELE E IR E+ + K +ELE QR RE E+
Sbjct: 2066 ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 2125
Query: 425 MYLKLQEALEDERQARQDE----ETVRKLQARLLE----EESSKRAELEKWHLEQQQAIQ 476
++Q++L E +A + E V +L+A++ E E +++ + L Q+ A +
Sbjct: 2126 ---RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK 2182
Query: 477 TTEAEKQELENQRVLKEQALQEAMEQ----LEQLELERKQALEQYEEVKKKLEMATNKTK 532
+AE++ KEQ LQ+ ++Q L+QL E + A EE ++ A +
Sbjct: 2183 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAA 2242
Query: 533 SWKDKVAHHEGL 544
+ +V E L
Sbjct: 2243 QSRRQVEEAERL 2254
Score = 54.7 bits (130), Expect = 2e-07
Identities = 68/237 (28%), Positives = 116/237 (48%), Gaps = 44/237 (18%)
Query: 322 RRKELRKKQLAEQEEL-ERQMKE-LQAANESKQQELEAV----RKKLEEAASRAAEEEKK 375
R ++L ++ LA+Q L E+ +KE +QA E+ + + EA +K+L + +R +E+K+
Sbjct: 2429 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2488
Query: 376 RLQTQVELQAR-FSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALE 434
++ Q+ + + F LE E+ ++Q+E S+E E+ RV E+ + +E +
Sbjct: 2489 QMAQQLAEETQGFQRTLEAER--QRQLE-----MSAEAERLKLRVAEMSRAQARAEE--D 2539
Query: 435 DERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQ----------AIQTTEAEKQE 484
+R +Q EE KL L + K ++ +++QQ AI E EK++
Sbjct: 2540 AQRFRKQAEEIGEKLHRTELATQE-KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK 2598
Query: 485 L------------ENQRVLKEQALQEAMEQLEQLELERKQALEQ----YEEVKKKLE 525
L E Q V +EQ LQE + L+Q L K +L Q E+ K KLE
Sbjct: 2599 LQQEAKLLQLKSEEMQTVQQEQLLQET-QALQQSFLSEKDSLLQRERFIEQEKAKLE 2654
Score = 53.9 bits (128), Expect = 4e-07
Identities = 69/282 (24%), Positives = 128/282 (45%), Gaps = 52/282 (18%)
Query: 321 QRRKELRKKQLAEQEELERQMKELQAANESKQ--------QELEAVRKKLEEAASRAAEE 372
+R +E + E+E+L+++ K LQ +E Q QE +A+++ +
Sbjct: 2583 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2642
Query: 373 EKKRLQTQVELQARFSTEL-------EREKLIRQQMEEQVAQKSSELEQYLQRVRELEDM 425
E+ Q + +L+ F E+ E ++ +QQME++ + + +E+ +R E E+
Sbjct: 2643 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2702
Query: 426 YLKLQEALED-ERQARQDEETVRKLQARLLEE----ESSKRAEL---EKWHLEQQQAIQT 477
+ QE L+ E+Q RQ EE + + RL E+ E RA L E+ Q A +T
Sbjct: 2703 VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2762
Query: 478 TEAEKQELEN--------------QRVLKEQALQEA----MEQLEQL--------ELERK 511
+ L+ +R + Q LQEA E+L++L EL R+
Sbjct: 2763 LPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARR 2822
Query: 512 QALEQYEEVKKKLEMATNKTKSWKDKVAHHEGLIR-LIEPGS 552
+ + Y ++ + +A K+ +K++ + L R L+ PG+
Sbjct: 2823 EDVRHY--LQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGT 2862
Score = 51.2 bits (121), Expect = 3e-06
Identities = 55/215 (25%), Positives = 100/215 (46%), Gaps = 14/215 (6%)
Query: 322 RRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEE--AASRAAEEEKKRLQT 379
R K+ ++ L E+ E +Q+ E A QE +R+ EE A RA E+ + +
Sbjct: 2394 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2453
Query: 380 QVELQARFSTELEREKLIRQQMEEQVAQKSSEL-EQYLQRVRELEDMYLKLQEALEDERQ 438
Q +A T L+ E + QQ +E +++ L E Q ++L + Q LE ERQ
Sbjct: 2454 QAVQEA---TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2510
Query: 439 ARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQE 498
RQ E + + +L + AE+ + ++ Q + +E+ + E A QE
Sbjct: 2511 -RQLEMSAEAERLKL------RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE 2563
Query: 499 AMEQLEQLELERKQALEQYEEVKKKL-EMATNKTK 532
+ ++ LE++R+Q+ E +++ + E+ K K
Sbjct: 2564 KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK 2598
Score = 48.9 bits (115), Expect = 1e-05
Identities = 48/198 (24%), Positives = 87/198 (43%), Gaps = 2/198 (1%)
Query: 342 KELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQM 401
+E+ A+E + +E +AV L E A + K+L+ Q E Q L E Q++
Sbjct: 1239 EEVLRAHEEQLKEAQAVPATLPEL--EATKASLKKLRAQAEAQQPTFDALRDELRGAQEV 1296
Query: 402 EEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKR 461
E++ Q+ E + ++R RE L+ +A+ + RQ E Q R E +
Sbjct: 1297 GERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPL 1356
Query: 462 AELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVK 521
+ +Q+ IQ + +++ +EQAL E +E+ + E ++ +QY
Sbjct: 1357 GAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAI 1416
Query: 522 KKLEMATNKTKSWKDKVA 539
K E+ K+ + VA
Sbjct: 1417 KDYELQLVTYKAQLEPVA 1434
Score = 35.4 bits (80), Expect = 0.15
Identities = 38/145 (26%), Positives = 63/145 (43%), Gaps = 21/145 (14%)
Query: 323 RKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVE 382
+KE + E E E+++KELQ A + +E R +E Q
Sbjct: 791 KKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESF--------------QAA 836
Query: 383 LQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQD 442
LQ ++S L+ I ++E A Q+ VRE E KLQEAL + +
Sbjct: 837 LQTQWSWMLQLCCCIEAHLKENAAYF-----QFFSDVREAEGQLQKLQEALR-RKYSCDR 890
Query: 443 EETVRKLQARLLEEESSKRAELEKW 467
TV +L+ LL++ ++ +L ++
Sbjct: 891 SATVTRLE-DLLQDAQDEKEQLNEY 914
Score = 30.4 bits (67), Expect = 4.7
Identities = 52/219 (23%), Positives = 85/219 (38%), Gaps = 23/219 (10%)
Query: 311 GSPPPHKEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAA 370
G P + E +QR R QL L K +A E EL+A +
Sbjct: 3324 GEPATYGELQQR---CRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEVPV 3380
Query: 371 EEEKKRLQTQVEL-QARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKL 429
K R T EL + + T +R++L+RQ +V +E + L
Sbjct: 3381 GGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVT---------------VEKVIKIL 3425
Query: 430 QEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQR 489
+E+ RQ+ + L+A + E L + EQ + +TT + EL + R
Sbjct: 3426 ITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVR 3485
Query: 490 VLKEQALQEAMEQLEQLELERKQALEQYEEVKKKLEMAT 528
L + + A LE + K+ + YE +++ L AT
Sbjct: 3486 TLLQGSGCLAGIYLE----DTKEKVSIYEAMRRGLLRAT 3520
Score = 30.4 bits (67), Expect = 4.7
Identities = 23/92 (25%), Positives = 44/92 (47%), Gaps = 5/92 (5%)
Query: 438 QARQDEETVRKLQARLLEEE---SSKRAELEKWHLEQQQAIQTTEAEKQELENQ--RVLK 492
Q +EET R + ++ S + + W + Q I + + + Q RV K
Sbjct: 3693 QVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTK 3752
Query: 493 EQALQEAMEQLEQLELERKQALEQYEEVKKKL 524
E+ + +E +E+ E+ R+Q L Y+ V+++L
Sbjct: 3753 ERMIIIIIEIIEKTEIIRQQGLASYDYVRRRL 3784
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 77.4 bits (189), Expect = 3e-14
Identities = 65/230 (28%), Positives = 116/230 (50%), Gaps = 16/230 (6%)
Query: 317 KEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKR 376
K+A + ++L + +LA QE++ ++ L+ + + E +R+ + E E EK++
Sbjct: 2386 KQAEEIGEKLHRTELATQEKVTL-VQTLEIQRQQSDHDAERLREAIAEL-----EREKEK 2439
Query: 377 LQTQVELQARFSTELEREKLIRQQMEEQVAQKS--SELEQYLQRVRELEDMYLKLQEALE 434
LQ + +L S E++ + + E Q Q+S SE + LQR R +E KL++ +
Sbjct: 2440 LQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQ 2499
Query: 435 DE-RQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQA---IQTTEAEKQELENQRV 490
DE +A+Q E ++ Q ++ +E A +E+ Q +A ++ + E Q+LE QR
Sbjct: 2500 DEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRR 2559
Query: 491 LKEQAL----QEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSWKD 536
+E+ L Q EQL+ LE + + AL EEV AT + +D
Sbjct: 2560 QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRD 2609
Score = 73.6 bits (179), Expect = 5e-13
Identities = 66/236 (27%), Positives = 113/236 (47%), Gaps = 31/236 (13%)
Query: 320 RQRRKELRKKQLAEQEELERQMKELQAANESKQ--QELEAVRKKLEEAASRAAEEEKKRL 377
RQ + E ++K+ AE E R E +AA E ++ Q LE +R + EEA R + E +R
Sbjct: 1479 RQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1538
Query: 378 Q------------TQVELQARFSTELEREKLIRQQMEEQ---VAQKSSELEQYLQRV--- 419
+ + ELQ++ ++ E+ + + ++E+ VAQ E E+ Q+
Sbjct: 1539 RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1598
Query: 420 --------RELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQ 471
RELE LK EAL QA + + QA +++ E + +
Sbjct: 1599 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1658
Query: 472 QQAIQTTEAEKQELENQRVLKEQALQE---AMEQLEQLELERKQALEQYEEVKKKL 524
+QA++ E +QELE QR L E Q+ A ++L +L E +Q +Q + ++++L
Sbjct: 1659 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1714
Score = 73.2 bits (178), Expect = 6e-13
Identities = 76/285 (26%), Positives = 140/285 (49%), Gaps = 50/285 (17%)
Query: 287 SASDKKKKQEW---IQAIHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQ---EELERQ 340
+A+ +K+QE + + + + +L +E+R ++ +++ AE EL +
Sbjct: 1721 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1780
Query: 341 MKELQA-ANESKQQELEAVRKKLEEAASRAAEEEK------------KRLQTQVELQARF 387
L+A A E+K+Q A E+AA + AE E+ RL+T+ E+ +
Sbjct: 1781 AARLRALAEEAKRQRQLAE----EDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK- 1835
Query: 388 STELEREKL---------IRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDE-- 436
E E E+L R+++EEQ AQ +++E+ L ++R+ D L+ Q+ L ++
Sbjct: 1836 EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTL 1895
Query: 437 RQARQDEETVRKLQARLLEEESSKRAELE----KWHLEQQQAIQTTEAEKQELENQRVL- 491
RQ RQ EE + L+A E+ ++ +AELE + + +++ E + E QR L
Sbjct: 1896 RQRRQVEEEILALKAS-FEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 1954
Query: 492 ---------KEQALQEAMEQLEQLELERKQALEQYEEVKKKLEMA 527
E+ +Q+++ E+ +RK ALE+ E +K K+E A
Sbjct: 1955 AEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 1999
Score = 70.9 bits (172), Expect = 3e-12
Identities = 69/264 (26%), Positives = 130/264 (49%), Gaps = 15/264 (5%)
Query: 291 KKKKQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQEELERQMKELQAA--N 348
+++ + W + + L +++ + + ++K+ AE+E R E QA
Sbjct: 1606 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1665
Query: 349 ESKQQELEAVRKKLEEAASR--AAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVA 406
E +QELE R+ E A + AAE+E RL+ + E Q +L E+L R Q E A
Sbjct: 1666 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE-QGEQQRQLLEEELARLQREAAAA 1724
Query: 407 -QKSSELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQA-----RLLEEESSK 460
QK ELE L +VR ++ L + E+E ++ E++ ++L+A R L EE+++
Sbjct: 1725 TQKRQELEAELAKVRAEMEVLLASKARAEEESRS-TSEKSKQRLEAEAGRFRELAEEAAR 1783
Query: 461 RAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQ--ALQEAMEQLEQLELERKQALEQYE 518
L + ++Q+ + +A +Q E +RVL E+ A+ EA + E+ K+ + E
Sbjct: 1784 LRALAE-EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE 1842
Query: 519 EVKKKLEMATNKTKSWKDKVAHHE 542
+++ E + + +++ A H+
Sbjct: 1843 RLRRLAEDEAFQRRRLEEQAAQHK 1866
Score = 70.9 bits (172), Expect = 3e-12
Identities = 61/272 (22%), Positives = 127/272 (46%), Gaps = 30/272 (11%)
Query: 285 EISASDKKKKQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRK-----------KQLAE 333
+++A ++++++E + + ++ + ARQR+ L + ++L E
Sbjct: 1952 QLAAEEERRRREAEERVQKSL-------AAEEEAARQRKAALEEVERLKAKVEEARRLRE 2004
Query: 334 QEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTELER 393
+ E E ++LQ A E+ Q+ L+A K A + +E ++ LQ + + + E E
Sbjct: 2005 RAEQE-SARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA 2063
Query: 394 EKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARL 453
+ ++ EE Q E Q ++V E E +L+++ E++ QAR + + +
Sbjct: 2064 ARRAAEEAEEARVQAEREAAQSRRQVEEAE----RLKQSAEEQAQARAQAQAAAEKLRKE 2119
Query: 454 LEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQA 513
E+E+++RA+ E+ L Q+QA E+E + EQ L++ + ++L R Q
Sbjct: 2120 AEQEAARRAQAEQAALRQKQAADA------EMEKHKKFAEQTLRQKAQVEQELTTLRLQ- 2172
Query: 514 LEQYEEVKKKLEMATNKTKSWKDKVAHHEGLI 545
LE+ + K L+ + K+ + A +
Sbjct: 2173 LEETDHQKNLLDEELQRLKAEATEAARQRSQV 2204
Score = 68.9 bits (167), Expect = 1e-11
Identities = 63/228 (27%), Positives = 114/228 (50%), Gaps = 35/228 (15%)
Query: 320 RQRRKELRKKQLAEQEELERQMKELQAANESKQQ-----------ELEAVRKK------L 362
R R +E ++ QEE ER +++Q ++ K+Q E EA R+K L
Sbjct: 1457 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1516
Query: 363 EEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVREL 422
EE +A E E++ Q +VE + LE + R E ++++S E+ Q R L
Sbjct: 1517 EELRLQAEEAERRLRQAEVERARQVQVALETAQ--RSAEAELQSKRASFAEKTAQLERSL 1574
Query: 423 EDMYLKLQEALED-ERQARQD-------EETVRKLQARLLEEESSKRAELEKWHLEQQQA 474
++ ++ + + E+ ER+A+Q EE R+L+ L+ + R L+ + QQ++
Sbjct: 1575 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS 1634
Query: 475 IQTTEAEKQELENQRVLK------EQALQEAMEQLEQLELERKQALEQ 516
+ EAEKQ+ E +R + EQA+++ +L + ELE+++ L +
Sbjct: 1635 LAQAEAEKQKEEAEREARRRGKAEEQAVRQ--RELAEQELEKQRQLAE 1680
Score = 68.9 bits (167), Expect = 1e-11
Identities = 73/244 (29%), Positives = 118/244 (48%), Gaps = 25/244 (10%)
Query: 308 LKLGSPPPHKEARQRRKE------LRKKQLAEQEELERQMKELQAANESKQQELEAVRKK 361
L+LG + E R KE R++QLA +EE R+ E + +S E EA R++
Sbjct: 1924 LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE-ERVQKSLAAEEEAARQR 1982
Query: 362 ---LEEAAS-RAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQ------VAQKSSE 411
LEE +A EE +RL+ + E ++ +L +E ++ E+ V QK E
Sbjct: 1983 KAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE 2042
Query: 412 LEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQ 471
L+Q LQ+ + + D +L+ E R+A ++ E R +QA E + R ++E+ +
Sbjct: 2043 LQQTLQQEQSVLD---QLRGEAEAARRAAEEAEEAR-VQAE--REAAQSRRQVEEAERLK 2096
Query: 472 QQAIQTTEAEKQELENQRVLKEQALQEAME--QLEQLELERKQALEQYEEVKKKLEMATN 529
Q A + +A Q L+++A QEA Q EQ L +KQA + E KK T
Sbjct: 2097 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2156
Query: 530 KTKS 533
+ K+
Sbjct: 2157 RQKA 2160
Score = 65.9 bits (159), Expect = 1e-10
Identities = 82/296 (27%), Positives = 136/296 (45%), Gaps = 29/296 (9%)
Query: 317 KEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKR 376
+ A+Q+ + R ++ AE+E Q+K +A Q E A +K L +A + +EE +R
Sbjct: 1590 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1649
Query: 377 ---LQTQVELQARFSTELEREKLIRQ-QMEEQVAQKSSELEQYLQRVRELEDMYLKLQEA 432
+ + E QA EL ++L +Q Q+ E AQ+ EQ L R+R + + ++
Sbjct: 1650 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1709
Query: 433 LEDERQARQDEETVRKLQARLLEEESSK-RAELEKWHLEQQQAIQ----TTEAEKQELEN 487
LE+E Q E + + LE E +K RAE+E + +A + T+E KQ LE
Sbjct: 1710 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1769
Query: 488 Q----RVLKEQALQ---EAMEQLEQLELERKQALEQYEEVKKKL-----------EMATN 529
+ R L E+A + A E Q +L + A Q E ++ L + T
Sbjct: 1770 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE 1829
Query: 530 KTKSWKDKVAHHEGLIRLIEPGSKNPHLITNWGPAAFTEAELEEREKNWKEKKTTE 585
+ K+K A +E L RL E + + AA +A++EER ++ +E
Sbjct: 1830 AEIALKEKEAENERLRRLAEDEAFQRRRLEE--QAAQHKADIEERLAQLRKASDSE 1883
Score = 63.5 bits (153), Expect = 5e-10
Identities = 55/211 (26%), Positives = 100/211 (47%), Gaps = 23/211 (10%)
Query: 328 KKQLAEQEELERQMKELQAANES-----KQQELEAVRKKLEEAASRAAEEEKKRLQTQVE 382
+K A + ELE ++ +++ E +Q ELEA R++ AAEEE++R + +
Sbjct: 1913 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR-----QLAAEEERRRREAEER 1967
Query: 383 LQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQD 442
+Q + E EE Q+ + LE+ ++R++ + +L+E E E ARQ
Sbjct: 1968 VQKSLAAE-----------EEAARQRKAALEE-VERLKAKVEEARRLRERAEQE-SARQL 2014
Query: 443 EETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQ 502
+ Q RL EE + +++ E QQ +Q ++ +L + +A +EA E
Sbjct: 2015 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2074
Query: 503 LEQLELERKQALEQYEEVKKKLEMATNKTKS 533
Q E E Q+ Q EE ++ + A + ++
Sbjct: 2075 RVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2105
Score = 62.0 bits (149), Expect = 1e-09
Identities = 54/212 (25%), Positives = 111/212 (52%), Gaps = 16/212 (7%)
Query: 317 KEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEE-EKK 375
+EA Q+R + +K A ++++ +ELQ + +Q L+ +R + E AA RAAEE E+
Sbjct: 2018 QEAAQKRLQAEEK--AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE-AARRAAEEAEEA 2074
Query: 376 RLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALED 435
R+Q + E A+ ++E + ++Q EEQ AQ ++ + +++R+ + E
Sbjct: 2075 RVQAERE-AAQSRRQVEEAERLKQSAEEQ-AQARAQAQAAAEKLRK--------EAEQEA 2124
Query: 436 ERQARQDEETVRKLQARLLEEESSKR--AELEKWHLEQQQAIQTTEAEKQELENQRVLKE 493
R+A+ ++ +R+ QA E E K+ + + + +Q + T + +E ++Q+ L +
Sbjct: 2125 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2184
Query: 494 QALQEAMEQLEQLELERKQALEQYEEVKKKLE 525
+ LQ + + +R Q E+ V+ ++E
Sbjct: 2185 EELQRLKAEATEAARQRSQVEEELFSVRVQME 2216
Score = 62.0 bits (149), Expect = 1e-09
Identities = 61/249 (24%), Positives = 119/249 (47%), Gaps = 43/249 (17%)
Query: 317 KEAR---QRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEE 373
+EAR +R ++Q+ E E L++ +E A Q E +RK+ E+ A+R A+ E
Sbjct: 2072 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2131
Query: 374 KKRLQ------TQVELQARFSTELEREKL--------IRQQMEEQVAQKSSELEQYLQRV 419
+ L+ ++E +F+ + R+K +R Q+EE QK+ L++ LQR+
Sbjct: 2132 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL-LDEELQRL 2190
Query: 420 RELEDMYLKLQEALEDER-QARQDEETVRKLQARL------------------LEEESSK 460
+ + + +E+E R E + KL+AR+ L+EE+ K
Sbjct: 2191 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2250
Query: 461 RA----ELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQA--L 514
E + + Q+A + + +++L QR L E+ L+E M+ +++ + +A L
Sbjct: 2251 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2310
Query: 515 EQYEEVKKK 523
+Q +E+ ++
Sbjct: 2311 QQQKELAQE 2319
Score = 59.7 bits (143), Expect = 7e-09
Identities = 70/267 (26%), Positives = 111/267 (41%), Gaps = 17/267 (6%)
Query: 318 EARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRL 377
+A + KEL+++ E E + Q S Q+EL+ +R+ E AE + K
Sbjct: 1363 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE------AEIQAKAR 1416
Query: 378 QTQVELQARFSTELEREKLIRQQMEEQVAQKSS---ELEQYLQRVRELEDMYLKLQEALE 434
Q + ++R E E +++R Q+E Q+ EL+ R E E + QE E
Sbjct: 1417 QAEAAERSRLRIE-EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1475
Query: 435 DERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQ 494
R+ QD E+ RK QA +E S +AE E E+Q+A+Q E + + E Q
Sbjct: 1476 RLRRQVQD-ESQRKRQAE-VELASRVKAEAEAAR-EKQRALQALEELRLQAEEAERRLRQ 1532
Query: 495 ALQEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSWKDKVAHHEGLIRLIEPGSKN 554
A E Q+ Q+ LE Q + E K+ A + + H + +L E +
Sbjct: 1533 AEVERARQV-QVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1591
Query: 555 PHLITNWGPAAFTEAELEEREKNWKEK 581
A E E + W+ K
Sbjct: 1592 AQ---QQAEAERAREEAERELERWQLK 1615
Score = 59.3 bits (142), Expect = 9e-09
Identities = 49/217 (22%), Positives = 105/217 (48%), Gaps = 19/217 (8%)
Query: 331 LAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTE 390
L EE ER ++ +A + E+EA +K + A A+ + + + ELQ R E
Sbjct: 1319 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1378
Query: 391 LEREKLIRQQMEEQVAQKSSELEQYLQRVRELE--DMYLKLQEALEDERQARQDEETVRK 448
+ R R++ Q+ +++ LQ++R+ ++ K ++A ER + EE +R
Sbjct: 1379 VVR----REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1434
Query: 449 LQARLLEEESSK----------RAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQE 498
++ +L E + RA E+ +++QA + E +++++++ K QA E
Sbjct: 1435 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1494
Query: 499 AMEQLE---QLELERKQALEQYEEVKKKLEMATNKTK 532
+++ + E+++AL+ EE++ + E A + +
Sbjct: 1495 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR 1531
Score = 59.3 bits (142), Expect = 9e-09
Identities = 65/229 (28%), Positives = 123/229 (53%), Gaps = 34/229 (14%)
Query: 319 ARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAA------SRAAEE 372
A +++++L + + + ER+ KELQ ++ + E VR+ EEAA R+ +E
Sbjct: 1346 ALEKQRQLAEAHAQAKAQAEREAKELQ-----QRMQEEVVRR--EEAAVDAQQQKRSIQE 1398
Query: 373 EKKRLQ--TQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVR-----ELEDM 425
E ++L+ ++ E+QA+ + + E + R ++EE++ +LE +R R EL+ +
Sbjct: 1399 ELQQLRQSSEAEIQAK-ARQAEAAERSRLRIEEEIRVVRLQLEA-TERQRGGAEGELQAL 1456
Query: 426 YLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQEL 485
+ +EA +RQA+++ E +R R +++ES ++ + E +E ++ EAE
Sbjct: 1457 RARAEEAEAQKRQAQEEAERLR----RQVQDESQRKRQAE---VELASRVK-AEAEAAR- 1507
Query: 486 ENQRVLKEQALQEAMEQLEQLELERKQA-LEQYEEVKKKLEMATNKTKS 533
E QR L QAL+E Q E+ E +QA +E+ +V+ LE A ++
Sbjct: 1508 EKQRAL--QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1554
Score = 58.5 bits (140), Expect = 2e-08
Identities = 55/241 (22%), Positives = 107/241 (44%), Gaps = 13/241 (5%)
Query: 299 QAIHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQE--ELERQMKELQAANESKQQELE 356
QA + + + K + + LR+K EQE L Q++E +EL+
Sbjct: 2129 QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2188
Query: 357 AVRKKLEEAASRAAEEEKKRLQTQVELQ----ARFSTELEREKLIRQQMEEQVAQKSSEL 412
++ + EAA + ++ E++ +V+++ + E E LI + + E
Sbjct: 2189 RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEA 2248
Query: 413 EQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEE-----ESSKRAELEKW 467
E+ Q E + + QEA + A +D R L ++L+E + + R + E
Sbjct: 2249 EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE 2308
Query: 468 HLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVKK-KLEM 526
L+QQ+ + +A + + E++ + +Q +E LE ER++ LE E ++ KL +
Sbjct: 2309 LLQQQKELAQEQARRLQ-EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRV 2367
Query: 527 A 527
A
Sbjct: 2368 A 2368
Score = 58.2 bits (139), Expect = 2e-08
Identities = 53/204 (25%), Positives = 97/204 (47%), Gaps = 13/204 (6%)
Query: 335 EELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTELERE 394
E L R +E + A + + +E R++L E A EK+R + QA+ E E +
Sbjct: 1317 ETLRRMEEEERLAEQQRAEE----RERLAEVE---AALEKQRQLAEAHAQAKAQAEREAK 1369
Query: 395 KLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQAR-QDEETVRKLQARL 453
+L +Q+M+E+V ++ Q+ R +++ +L+++ E E QA+ + E + + R+
Sbjct: 1370 EL-QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1428
Query: 454 LEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELE---- 509
EE R +LE ++ A +A + E K QA +EA Q++ E
Sbjct: 1429 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1488
Query: 510 RKQALEQYEEVKKKLEMATNKTKS 533
R+ +E VK + E A K ++
Sbjct: 1489 RQAEVELASRVKAEAEAAREKQRA 1512
Score = 55.8 bits (133), Expect = 1e-07
Identities = 48/235 (20%), Positives = 109/235 (46%), Gaps = 15/235 (6%)
Query: 290 DKKKKQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQEELERQMKELQAANE 349
D +++QE IQA+ P +++ R++LR++Q A EE+ER ++++
Sbjct: 1203 DARRRQEQIQAM-------------PLADSQAVREQLRQEQ-ALLEEIERHGEKVEECQR 1248
Query: 350 SKQQELEAVRK-KLEEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQK 408
+Q + A++ +L+ +A E + ++Q+ + ++ +R E
Sbjct: 1249 FAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLT 1308
Query: 409 SSELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWH 468
S ++ + +R +E+ ++ +ER+ + E + Q +L E + +A+ E+
Sbjct: 1309 SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA 1368
Query: 469 LEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVKKK 523
E QQ +Q ++E +++++QE ++QL Q QA + E ++
Sbjct: 1369 KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1423
Score = 55.5 bits (132), Expect = 1e-07
Identities = 69/252 (27%), Positives = 118/252 (46%), Gaps = 32/252 (12%)
Query: 318 EARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAAS--RAAEEEKK 375
EA QRR+ L ++ + ++E ++ +L+ A++S ELE + +E+ R EEE
Sbjct: 1851 EAFQRRR-LEEQAAQHKADIEERLAQLRKASDS---ELERQKGLVEDTLRQRRQVEEEIL 1906
Query: 376 RLQTQVELQARFSTELEREK-LIRQQMEEQVAQKS-SELEQYLQRV---------RELED 424
L+ E A ELE E IR E+ + K +ELE QR RE E+
Sbjct: 1907 ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 1966
Query: 425 MYLKLQEALEDERQARQDE----ETVRKLQARLLE----EESSKRAELEKWHLEQQQAIQ 476
++Q++L E +A + E V +L+A++ E E +++ + L Q+ A +
Sbjct: 1967 ---RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK 2023
Query: 477 TTEAEKQELENQRVLKEQALQEAMEQ----LEQLELERKQALEQYEEVKKKLEMATNKTK 532
+AE++ KEQ LQ+ ++Q L+QL E + A EE ++ A +
Sbjct: 2024 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAA 2083
Query: 533 SWKDKVAHHEGL 544
+ +V E L
Sbjct: 2084 QSRRQVEEAERL 2095
Score = 54.7 bits (130), Expect = 2e-07
Identities = 68/237 (28%), Positives = 116/237 (48%), Gaps = 44/237 (18%)
Query: 322 RRKELRKKQLAEQEEL-ERQMKE-LQAANESKQQELEAV----RKKLEEAASRAAEEEKK 375
R ++L ++ LA+Q L E+ +KE +QA E+ + + EA +K+L + +R +E+K+
Sbjct: 2270 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2329
Query: 376 RLQTQVELQAR-FSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALE 434
++ Q+ + + F LE E+ ++Q+E S+E E+ RV E+ + +E +
Sbjct: 2330 QMAQQLAEETQGFQRTLEAER--QRQLE-----MSAEAERLKLRVAEMSRAQARAEE--D 2380
Query: 435 DERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQ----------AIQTTEAEKQE 484
+R +Q EE KL L + K ++ +++QQ AI E EK++
Sbjct: 2381 AQRFRKQAEEIGEKLHRTELATQE-KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK 2439
Query: 485 L------------ENQRVLKEQALQEAMEQLEQLELERKQALEQ----YEEVKKKLE 525
L E Q V +EQ LQE + L+Q L K +L Q E+ K KLE
Sbjct: 2440 LQQEAKLLQLKSEEMQTVQQEQLLQET-QALQQSFLSEKDSLLQRERFIEQEKAKLE 2495
Score = 53.9 bits (128), Expect = 4e-07
Identities = 69/282 (24%), Positives = 128/282 (45%), Gaps = 52/282 (18%)
Query: 321 QRRKELRKKQLAEQEELERQMKELQAANESKQ--------QELEAVRKKLEEAASRAAEE 372
+R +E + E+E+L+++ K LQ +E Q QE +A+++ +
Sbjct: 2424 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2483
Query: 373 EKKRLQTQVELQARFSTEL-------EREKLIRQQMEEQVAQKSSELEQYLQRVRELEDM 425
E+ Q + +L+ F E+ E ++ +QQME++ + + +E+ +R E E+
Sbjct: 2484 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2543
Query: 426 YLKLQEALED-ERQARQDEETVRKLQARLLEE----ESSKRAEL---EKWHLEQQQAIQT 477
+ QE L+ E+Q RQ EE + + RL E+ E RA L E+ Q A +T
Sbjct: 2544 VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2603
Query: 478 TEAEKQELEN--------------QRVLKEQALQEA----MEQLEQL--------ELERK 511
+ L+ +R + Q LQEA E+L++L EL R+
Sbjct: 2604 LPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARR 2663
Query: 512 QALEQYEEVKKKLEMATNKTKSWKDKVAHHEGLIR-LIEPGS 552
+ + Y ++ + +A K+ +K++ + L R L+ PG+
Sbjct: 2664 EDVRHY--LQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGT 2703
Score = 51.2 bits (121), Expect = 3e-06
Identities = 55/215 (25%), Positives = 100/215 (46%), Gaps = 14/215 (6%)
Query: 322 RRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEE--AASRAAEEEKKRLQT 379
R K+ ++ L E+ E +Q+ E A QE +R+ EE A RA E+ + +
Sbjct: 2235 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2294
Query: 380 QVELQARFSTELEREKLIRQQMEEQVAQKSSEL-EQYLQRVRELEDMYLKLQEALEDERQ 438
Q +A T L+ E + QQ +E +++ L E Q ++L + Q LE ERQ
Sbjct: 2295 QAVQEA---TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2351
Query: 439 ARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQE 498
RQ E + + +L + AE+ + ++ Q + +E+ + E A QE
Sbjct: 2352 -RQLEMSAEAERLKL------RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE 2404
Query: 499 AMEQLEQLELERKQALEQYEEVKKKL-EMATNKTK 532
+ ++ LE++R+Q+ E +++ + E+ K K
Sbjct: 2405 KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK 2439
Score = 48.9 bits (115), Expect = 1e-05
Identities = 48/198 (24%), Positives = 87/198 (43%), Gaps = 2/198 (1%)
Query: 342 KELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQM 401
+E+ A+E + +E +AV L E A + K+L+ Q E Q L E Q++
Sbjct: 1080 EEVLRAHEEQLKEAQAVPATLPEL--EATKASLKKLRAQAEAQQPTFDALRDELRGAQEV 1137
Query: 402 EEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKR 461
E++ Q+ E + ++R RE L+ +A+ + RQ E Q R E +
Sbjct: 1138 GERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPL 1197
Query: 462 AELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVK 521
+ +Q+ IQ + +++ +EQAL E +E+ + E ++ +QY
Sbjct: 1198 GAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAI 1257
Query: 522 KKLEMATNKTKSWKDKVA 539
K E+ K+ + VA
Sbjct: 1258 KDYELQLVTYKAQLEPVA 1275
Score = 35.4 bits (80), Expect = 0.15
Identities = 38/145 (26%), Positives = 63/145 (43%), Gaps = 21/145 (14%)
Query: 323 RKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVE 382
+KE + E E E+++KELQ A + +E R +E Q
Sbjct: 632 KKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESF--------------QAA 677
Query: 383 LQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQD 442
LQ ++S L+ I ++E A Q+ VRE E KLQEAL + +
Sbjct: 678 LQTQWSWMLQLCCCIEAHLKENAAYF-----QFFSDVREAEGQLQKLQEALR-RKYSCDR 731
Query: 443 EETVRKLQARLLEEESSKRAELEKW 467
TV +L+ LL++ ++ +L ++
Sbjct: 732 SATVTRLE-DLLQDAQDEKEQLNEY 755
Score = 30.4 bits (67), Expect = 4.7
Identities = 52/219 (23%), Positives = 85/219 (38%), Gaps = 23/219 (10%)
Query: 311 GSPPPHKEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAA 370
G P + E +QR R QL L K +A E EL+A +
Sbjct: 3165 GEPATYGELQQR---CRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEVPV 3221
Query: 371 EEEKKRLQTQVEL-QARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKL 429
K R T EL + + T +R++L+RQ +V +E + L
Sbjct: 3222 GGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVT---------------VEKVIKIL 3266
Query: 430 QEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQR 489
+E+ RQ+ + L+A + E L + EQ + +TT + EL + R
Sbjct: 3267 ITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVR 3326
Query: 490 VLKEQALQEAMEQLEQLELERKQALEQYEEVKKKLEMAT 528
L + + A LE + K+ + YE +++ L AT
Sbjct: 3327 TLLQGSGCLAGIYLE----DTKEKVSIYEAMRRGLLRAT 3361
Score = 30.4 bits (67), Expect = 4.7
Identities = 23/92 (25%), Positives = 44/92 (47%), Gaps = 5/92 (5%)
Query: 438 QARQDEETVRKLQARLLEEE---SSKRAELEKWHLEQQQAIQTTEAEKQELENQ--RVLK 492
Q +EET R + ++ S + + W + Q I + + + Q RV K
Sbjct: 3534 QVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTK 3593
Query: 493 EQALQEAMEQLEQLELERKQALEQYEEVKKKL 524
E+ + +E +E+ E+ R+Q L Y+ V+++L
Sbjct: 3594 ERMIIIIIEIIEKTEIIRQQGLASYDYVRRRL 3625
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 77.4 bits (189), Expect = 3e-14
Identities = 65/230 (28%), Positives = 116/230 (50%), Gaps = 16/230 (6%)
Query: 317 KEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKR 376
K+A + ++L + +LA QE++ ++ L+ + + E +R+ + E E EK++
Sbjct: 2394 KQAEEIGEKLHRTELATQEKVTL-VQTLEIQRQQSDHDAERLREAIAEL-----EREKEK 2447
Query: 377 LQTQVELQARFSTELEREKLIRQQMEEQVAQKS--SELEQYLQRVRELEDMYLKLQEALE 434
LQ + +L S E++ + + E Q Q+S SE + LQR R +E KL++ +
Sbjct: 2448 LQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQ 2507
Query: 435 DE-RQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQA---IQTTEAEKQELENQRV 490
DE +A+Q E ++ Q ++ +E A +E+ Q +A ++ + E Q+LE QR
Sbjct: 2508 DEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRR 2567
Query: 491 LKEQAL----QEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSWKD 536
+E+ L Q EQL+ LE + + AL EEV AT + +D
Sbjct: 2568 QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRD 2617
Score = 73.6 bits (179), Expect = 5e-13
Identities = 66/236 (27%), Positives = 113/236 (47%), Gaps = 31/236 (13%)
Query: 320 RQRRKELRKKQLAEQEELERQMKELQAANESKQ--QELEAVRKKLEEAASRAAEEEKKRL 377
RQ + E ++K+ AE E R E +AA E ++ Q LE +R + EEA R + E +R
Sbjct: 1487 RQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1546
Query: 378 Q------------TQVELQARFSTELEREKLIRQQMEEQ---VAQKSSELEQYLQRV--- 419
+ + ELQ++ ++ E+ + + ++E+ VAQ E E+ Q+
Sbjct: 1547 RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1606
Query: 420 --------RELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQ 471
RELE LK EAL QA + + QA +++ E + +
Sbjct: 1607 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1666
Query: 472 QQAIQTTEAEKQELENQRVLKEQALQE---AMEQLEQLELERKQALEQYEEVKKKL 524
+QA++ E +QELE QR L E Q+ A ++L +L E +Q +Q + ++++L
Sbjct: 1667 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1722
Score = 73.2 bits (178), Expect = 6e-13
Identities = 76/285 (26%), Positives = 140/285 (49%), Gaps = 50/285 (17%)
Query: 287 SASDKKKKQEW---IQAIHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQ---EELERQ 340
+A+ +K+QE + + + + +L +E+R ++ +++ AE EL +
Sbjct: 1729 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1788
Query: 341 MKELQA-ANESKQQELEAVRKKLEEAASRAAEEEK------------KRLQTQVELQARF 387
L+A A E+K+Q A E+AA + AE E+ RL+T+ E+ +
Sbjct: 1789 AARLRALAEEAKRQRQLAE----EDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK- 1843
Query: 388 STELEREKL---------IRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDE-- 436
E E E+L R+++EEQ AQ +++E+ L ++R+ D L+ Q+ L ++
Sbjct: 1844 EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTL 1903
Query: 437 RQARQDEETVRKLQARLLEEESSKRAELE----KWHLEQQQAIQTTEAEKQELENQRVL- 491
RQ RQ EE + L+A E+ ++ +AELE + + +++ E + E QR L
Sbjct: 1904 RQRRQVEEEILALKAS-FEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 1962
Query: 492 ---------KEQALQEAMEQLEQLELERKQALEQYEEVKKKLEMA 527
E+ +Q+++ E+ +RK ALE+ E +K K+E A
Sbjct: 1963 AEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2007
Score = 70.9 bits (172), Expect = 3e-12
Identities = 69/264 (26%), Positives = 130/264 (49%), Gaps = 15/264 (5%)
Query: 291 KKKKQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQEELERQMKELQAA--N 348
+++ + W + + L +++ + + ++K+ AE+E R E QA
Sbjct: 1614 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1673
Query: 349 ESKQQELEAVRKKLEEAASR--AAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVA 406
E +QELE R+ E A + AAE+E RL+ + E Q +L E+L R Q E A
Sbjct: 1674 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE-QGEQQRQLLEEELARLQREAAAA 1732
Query: 407 -QKSSELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQA-----RLLEEESSK 460
QK ELE L +VR ++ L + E+E ++ E++ ++L+A R L EE+++
Sbjct: 1733 TQKRQELEAELAKVRAEMEVLLASKARAEEESRS-TSEKSKQRLEAEAGRFRELAEEAAR 1791
Query: 461 RAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQ--ALQEAMEQLEQLELERKQALEQYE 518
L + ++Q+ + +A +Q E +RVL E+ A+ EA + E+ K+ + E
Sbjct: 1792 LRALAE-EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE 1850
Query: 519 EVKKKLEMATNKTKSWKDKVAHHE 542
+++ E + + +++ A H+
Sbjct: 1851 RLRRLAEDEAFQRRRLEEQAAQHK 1874
Score = 70.9 bits (172), Expect = 3e-12
Identities = 61/272 (22%), Positives = 127/272 (46%), Gaps = 30/272 (11%)
Query: 285 EISASDKKKKQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRK-----------KQLAE 333
+++A ++++++E + + ++ + ARQR+ L + ++L E
Sbjct: 1960 QLAAEEERRRREAEERVQKSL-------AAEEEAARQRKAALEEVERLKAKVEEARRLRE 2012
Query: 334 QEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTELER 393
+ E E ++LQ A E+ Q+ L+A K A + +E ++ LQ + + + E E
Sbjct: 2013 RAEQE-SARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA 2071
Query: 394 EKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARL 453
+ ++ EE Q E Q ++V E E +L+++ E++ QAR + + +
Sbjct: 2072 ARRAAEEAEEARVQAEREAAQSRRQVEEAE----RLKQSAEEQAQARAQAQAAAEKLRKE 2127
Query: 454 LEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQA 513
E+E+++RA+ E+ L Q+QA E+E + EQ L++ + ++L R Q
Sbjct: 2128 AEQEAARRAQAEQAALRQKQAADA------EMEKHKKFAEQTLRQKAQVEQELTTLRLQ- 2180
Query: 514 LEQYEEVKKKLEMATNKTKSWKDKVAHHEGLI 545
LE+ + K L+ + K+ + A +
Sbjct: 2181 LEETDHQKNLLDEELQRLKAEATEAARQRSQV 2212
Score = 68.9 bits (167), Expect = 1e-11
Identities = 63/228 (27%), Positives = 114/228 (50%), Gaps = 35/228 (15%)
Query: 320 RQRRKELRKKQLAEQEELERQMKELQAANESKQQ-----------ELEAVRKK------L 362
R R +E ++ QEE ER +++Q ++ K+Q E EA R+K L
Sbjct: 1465 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1524
Query: 363 EEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVREL 422
EE +A E E++ Q +VE + LE + R E ++++S E+ Q R L
Sbjct: 1525 EELRLQAEEAERRLRQAEVERARQVQVALETAQ--RSAEAELQSKRASFAEKTAQLERSL 1582
Query: 423 EDMYLKLQEALED-ERQARQD-------EETVRKLQARLLEEESSKRAELEKWHLEQQQA 474
++ ++ + + E+ ER+A+Q EE R+L+ L+ + R L+ + QQ++
Sbjct: 1583 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS 1642
Query: 475 IQTTEAEKQELENQRVLK------EQALQEAMEQLEQLELERKQALEQ 516
+ EAEKQ+ E +R + EQA+++ +L + ELE+++ L +
Sbjct: 1643 LAQAEAEKQKEEAEREARRRGKAEEQAVRQ--RELAEQELEKQRQLAE 1688
Score = 68.9 bits (167), Expect = 1e-11
Identities = 73/244 (29%), Positives = 118/244 (48%), Gaps = 25/244 (10%)
Query: 308 LKLGSPPPHKEARQRRKE------LRKKQLAEQEELERQMKELQAANESKQQELEAVRKK 361
L+LG + E R KE R++QLA +EE R+ E + +S E EA R++
Sbjct: 1932 LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE-ERVQKSLAAEEEAARQR 1990
Query: 362 ---LEEAAS-RAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQ------VAQKSSE 411
LEE +A EE +RL+ + E ++ +L +E ++ E+ V QK E
Sbjct: 1991 KAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE 2050
Query: 412 LEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQ 471
L+Q LQ+ + + D +L+ E R+A ++ E R +QA E + R ++E+ +
Sbjct: 2051 LQQTLQQEQSVLD---QLRGEAEAARRAAEEAEEAR-VQAE--REAAQSRRQVEEAERLK 2104
Query: 472 QQAIQTTEAEKQELENQRVLKEQALQEAME--QLEQLELERKQALEQYEEVKKKLEMATN 529
Q A + +A Q L+++A QEA Q EQ L +KQA + E KK T
Sbjct: 2105 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2164
Query: 530 KTKS 533
+ K+
Sbjct: 2165 RQKA 2168
Score = 65.9 bits (159), Expect = 1e-10
Identities = 82/296 (27%), Positives = 136/296 (45%), Gaps = 29/296 (9%)
Query: 317 KEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKR 376
+ A+Q+ + R ++ AE+E Q+K +A Q E A +K L +A + +EE +R
Sbjct: 1598 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1657
Query: 377 ---LQTQVELQARFSTELEREKLIRQ-QMEEQVAQKSSELEQYLQRVRELEDMYLKLQEA 432
+ + E QA EL ++L +Q Q+ E AQ+ EQ L R+R + + ++
Sbjct: 1658 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1717
Query: 433 LEDERQARQDEETVRKLQARLLEEESSK-RAELEKWHLEQQQAIQ----TTEAEKQELEN 487
LE+E Q E + + LE E +K RAE+E + +A + T+E KQ LE
Sbjct: 1718 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1777
Query: 488 Q----RVLKEQALQ---EAMEQLEQLELERKQALEQYEEVKKKL-----------EMATN 529
+ R L E+A + A E Q +L + A Q E ++ L + T
Sbjct: 1778 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE 1837
Query: 530 KTKSWKDKVAHHEGLIRLIEPGSKNPHLITNWGPAAFTEAELEEREKNWKEKKTTE 585
+ K+K A +E L RL E + + AA +A++EER ++ +E
Sbjct: 1838 AEIALKEKEAENERLRRLAEDEAFQRRRLEE--QAAQHKADIEERLAQLRKASDSE 1891
Score = 63.5 bits (153), Expect = 5e-10
Identities = 55/211 (26%), Positives = 100/211 (47%), Gaps = 23/211 (10%)
Query: 328 KKQLAEQEELERQMKELQAANES-----KQQELEAVRKKLEEAASRAAEEEKKRLQTQVE 382
+K A + ELE ++ +++ E +Q ELEA R++ AAEEE++R + +
Sbjct: 1921 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR-----QLAAEEERRRREAEER 1975
Query: 383 LQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQD 442
+Q + E EE Q+ + LE+ ++R++ + +L+E E E ARQ
Sbjct: 1976 VQKSLAAE-----------EEAARQRKAALEE-VERLKAKVEEARRLRERAEQE-SARQL 2022
Query: 443 EETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQ 502
+ Q RL EE + +++ E QQ +Q ++ +L + +A +EA E
Sbjct: 2023 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2082
Query: 503 LEQLELERKQALEQYEEVKKKLEMATNKTKS 533
Q E E Q+ Q EE ++ + A + ++
Sbjct: 2083 RVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2113
Score = 62.0 bits (149), Expect = 1e-09
Identities = 54/212 (25%), Positives = 111/212 (52%), Gaps = 16/212 (7%)
Query: 317 KEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEE-EKK 375
+EA Q+R + +K A ++++ +ELQ + +Q L+ +R + E AA RAAEE E+
Sbjct: 2026 QEAAQKRLQAEEK--AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE-AARRAAEEAEEA 2082
Query: 376 RLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALED 435
R+Q + E A+ ++E + ++Q EEQ AQ ++ + +++R+ + E
Sbjct: 2083 RVQAERE-AAQSRRQVEEAERLKQSAEEQ-AQARAQAQAAAEKLRK--------EAEQEA 2132
Query: 436 ERQARQDEETVRKLQARLLEEESSKR--AELEKWHLEQQQAIQTTEAEKQELENQRVLKE 493
R+A+ ++ +R+ QA E E K+ + + + +Q + T + +E ++Q+ L +
Sbjct: 2133 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2192
Query: 494 QALQEAMEQLEQLELERKQALEQYEEVKKKLE 525
+ LQ + + +R Q E+ V+ ++E
Sbjct: 2193 EELQRLKAEATEAARQRSQVEEELFSVRVQME 2224
Score = 62.0 bits (149), Expect = 1e-09
Identities = 61/249 (24%), Positives = 119/249 (47%), Gaps = 43/249 (17%)
Query: 317 KEAR---QRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEE 373
+EAR +R ++Q+ E E L++ +E A Q E +RK+ E+ A+R A+ E
Sbjct: 2080 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2139
Query: 374 KKRLQ------TQVELQARFSTELEREKL--------IRQQMEEQVAQKSSELEQYLQRV 419
+ L+ ++E +F+ + R+K +R Q+EE QK+ L++ LQR+
Sbjct: 2140 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL-LDEELQRL 2198
Query: 420 RELEDMYLKLQEALEDER-QARQDEETVRKLQARL------------------LEEESSK 460
+ + + +E+E R E + KL+AR+ L+EE+ K
Sbjct: 2199 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2258
Query: 461 RA----ELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQA--L 514
E + + Q+A + + +++L QR L E+ L+E M+ +++ + +A L
Sbjct: 2259 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2318
Query: 515 EQYEEVKKK 523
+Q +E+ ++
Sbjct: 2319 QQQKELAQE 2327
Score = 59.7 bits (143), Expect = 7e-09
Identities = 70/267 (26%), Positives = 111/267 (41%), Gaps = 17/267 (6%)
Query: 318 EARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRL 377
+A + KEL+++ E E + Q S Q+EL+ +R+ E AE + K
Sbjct: 1371 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE------AEIQAKAR 1424
Query: 378 QTQVELQARFSTELEREKLIRQQMEEQVAQKSS---ELEQYLQRVRELEDMYLKLQEALE 434
Q + ++R E E +++R Q+E Q+ EL+ R E E + QE E
Sbjct: 1425 QAEAAERSRLRIE-EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1483
Query: 435 DERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQ 494
R+ QD E+ RK QA +E S +AE E E+Q+A+Q E + + E Q
Sbjct: 1484 RLRRQVQD-ESQRKRQAE-VELASRVKAEAEAAR-EKQRALQALEELRLQAEEAERRLRQ 1540
Query: 495 ALQEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSWKDKVAHHEGLIRLIEPGSKN 554
A E Q+ Q+ LE Q + E K+ A + + H + +L E +
Sbjct: 1541 AEVERARQV-QVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1599
Query: 555 PHLITNWGPAAFTEAELEEREKNWKEK 581
A E E + W+ K
Sbjct: 1600 AQ---QQAEAERAREEAERELERWQLK 1623
Score = 59.3 bits (142), Expect = 9e-09
Identities = 49/217 (22%), Positives = 105/217 (48%), Gaps = 19/217 (8%)
Query: 331 LAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTE 390
L EE ER ++ +A + E+EA +K + A A+ + + + ELQ R E
Sbjct: 1327 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1386
Query: 391 LEREKLIRQQMEEQVAQKSSELEQYLQRVRELE--DMYLKLQEALEDERQARQDEETVRK 448
+ R R++ Q+ +++ LQ++R+ ++ K ++A ER + EE +R
Sbjct: 1387 VVR----REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1442
Query: 449 LQARLLEEESSK----------RAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQE 498
++ +L E + RA E+ +++QA + E +++++++ K QA E
Sbjct: 1443 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1502
Query: 499 AMEQLE---QLELERKQALEQYEEVKKKLEMATNKTK 532
+++ + E+++AL+ EE++ + E A + +
Sbjct: 1503 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR 1539
Score = 59.3 bits (142), Expect = 9e-09
Identities = 65/229 (28%), Positives = 123/229 (53%), Gaps = 34/229 (14%)
Query: 319 ARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAA------SRAAEE 372
A +++++L + + + ER+ KELQ ++ + E VR+ EEAA R+ +E
Sbjct: 1354 ALEKQRQLAEAHAQAKAQAEREAKELQ-----QRMQEEVVRR--EEAAVDAQQQKRSIQE 1406
Query: 373 EKKRLQ--TQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVR-----ELEDM 425
E ++L+ ++ E+QA+ + + E + R ++EE++ +LE +R R EL+ +
Sbjct: 1407 ELQQLRQSSEAEIQAK-ARQAEAAERSRLRIEEEIRVVRLQLEA-TERQRGGAEGELQAL 1464
Query: 426 YLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQEL 485
+ +EA +RQA+++ E +R R +++ES ++ + E +E ++ EAE
Sbjct: 1465 RARAEEAEAQKRQAQEEAERLR----RQVQDESQRKRQAE---VELASRVK-AEAEAAR- 1515
Query: 486 ENQRVLKEQALQEAMEQLEQLELERKQA-LEQYEEVKKKLEMATNKTKS 533
E QR L QAL+E Q E+ E +QA +E+ +V+ LE A ++
Sbjct: 1516 EKQRAL--QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1562
Score = 58.5 bits (140), Expect = 2e-08
Identities = 55/241 (22%), Positives = 107/241 (44%), Gaps = 13/241 (5%)
Query: 299 QAIHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQE--ELERQMKELQAANESKQQELE 356
QA + + + K + + LR+K EQE L Q++E +EL+
Sbjct: 2137 QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2196
Query: 357 AVRKKLEEAASRAAEEEKKRLQTQVELQ----ARFSTELEREKLIRQQMEEQVAQKSSEL 412
++ + EAA + ++ E++ +V+++ + E E LI + + E
Sbjct: 2197 RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEA 2256
Query: 413 EQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEE-----ESSKRAELEKW 467
E+ Q E + + QEA + A +D R L ++L+E + + R + E
Sbjct: 2257 EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE 2316
Query: 468 HLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVKK-KLEM 526
L+QQ+ + +A + + E++ + +Q +E LE ER++ LE E ++ KL +
Sbjct: 2317 LLQQQKELAQEQARRLQ-EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRV 2375
Query: 527 A 527
A
Sbjct: 2376 A 2376
Score = 58.2 bits (139), Expect = 2e-08
Identities = 53/204 (25%), Positives = 97/204 (47%), Gaps = 13/204 (6%)
Query: 335 EELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTELERE 394
E L R +E + A + + +E R++L E A EK+R + QA+ E E +
Sbjct: 1325 ETLRRMEEEERLAEQQRAEE----RERLAEVE---AALEKQRQLAEAHAQAKAQAEREAK 1377
Query: 395 KLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQAR-QDEETVRKLQARL 453
+L +Q+M+E+V ++ Q+ R +++ +L+++ E E QA+ + E + + R+
Sbjct: 1378 EL-QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1436
Query: 454 LEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELE---- 509
EE R +LE ++ A +A + E K QA +EA Q++ E
Sbjct: 1437 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1496
Query: 510 RKQALEQYEEVKKKLEMATNKTKS 533
R+ +E VK + E A K ++
Sbjct: 1497 RQAEVELASRVKAEAEAAREKQRA 1520
Score = 55.8 bits (133), Expect = 1e-07
Identities = 48/235 (20%), Positives = 109/235 (46%), Gaps = 15/235 (6%)
Query: 290 DKKKKQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQEELERQMKELQAANE 349
D +++QE IQA+ P +++ R++LR++Q A EE+ER ++++
Sbjct: 1211 DARRRQEQIQAM-------------PLADSQAVREQLRQEQ-ALLEEIERHGEKVEECQR 1256
Query: 350 SKQQELEAVRK-KLEEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQK 408
+Q + A++ +L+ +A E + ++Q+ + ++ +R E
Sbjct: 1257 FAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLT 1316
Query: 409 SSELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWH 468
S ++ + +R +E+ ++ +ER+ + E + Q +L E + +A+ E+
Sbjct: 1317 SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA 1376
Query: 469 LEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVKKK 523
E QQ +Q ++E +++++QE ++QL Q QA + E ++
Sbjct: 1377 KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1431
Score = 55.5 bits (132), Expect = 1e-07
Identities = 69/252 (27%), Positives = 118/252 (46%), Gaps = 32/252 (12%)
Query: 318 EARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAAS--RAAEEEKK 375
EA QRR+ L ++ + ++E ++ +L+ A++S ELE + +E+ R EEE
Sbjct: 1859 EAFQRRR-LEEQAAQHKADIEERLAQLRKASDS---ELERQKGLVEDTLRQRRQVEEEIL 1914
Query: 376 RLQTQVELQARFSTELEREK-LIRQQMEEQVAQKS-SELEQYLQRV---------RELED 424
L+ E A ELE E IR E+ + K +ELE QR RE E+
Sbjct: 1915 ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 1974
Query: 425 MYLKLQEALEDERQARQDE----ETVRKLQARLLE----EESSKRAELEKWHLEQQQAIQ 476
++Q++L E +A + E V +L+A++ E E +++ + L Q+ A +
Sbjct: 1975 ---RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK 2031
Query: 477 TTEAEKQELENQRVLKEQALQEAMEQ----LEQLELERKQALEQYEEVKKKLEMATNKTK 532
+AE++ KEQ LQ+ ++Q L+QL E + A EE ++ A +
Sbjct: 2032 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAA 2091
Query: 533 SWKDKVAHHEGL 544
+ +V E L
Sbjct: 2092 QSRRQVEEAERL 2103
Score = 54.7 bits (130), Expect = 2e-07
Identities = 68/237 (28%), Positives = 116/237 (48%), Gaps = 44/237 (18%)
Query: 322 RRKELRKKQLAEQEEL-ERQMKE-LQAANESKQQELEAV----RKKLEEAASRAAEEEKK 375
R ++L ++ LA+Q L E+ +KE +QA E+ + + EA +K+L + +R +E+K+
Sbjct: 2278 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2337
Query: 376 RLQTQVELQAR-FSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALE 434
++ Q+ + + F LE E+ ++Q+E S+E E+ RV E+ + +E +
Sbjct: 2338 QMAQQLAEETQGFQRTLEAER--QRQLE-----MSAEAERLKLRVAEMSRAQARAEE--D 2388
Query: 435 DERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQ----------AIQTTEAEKQE 484
+R +Q EE KL L + K ++ +++QQ AI E EK++
Sbjct: 2389 AQRFRKQAEEIGEKLHRTELATQE-KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK 2447
Query: 485 L------------ENQRVLKEQALQEAMEQLEQLELERKQALEQ----YEEVKKKLE 525
L E Q V +EQ LQE + L+Q L K +L Q E+ K KLE
Sbjct: 2448 LQQEAKLLQLKSEEMQTVQQEQLLQET-QALQQSFLSEKDSLLQRERFIEQEKAKLE 2503
Score = 53.9 bits (128), Expect = 4e-07
Identities = 69/282 (24%), Positives = 128/282 (45%), Gaps = 52/282 (18%)
Query: 321 QRRKELRKKQLAEQEELERQMKELQAANESKQ--------QELEAVRKKLEEAASRAAEE 372
+R +E + E+E+L+++ K LQ +E Q QE +A+++ +
Sbjct: 2432 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2491
Query: 373 EKKRLQTQVELQARFSTEL-------EREKLIRQQMEEQVAQKSSELEQYLQRVRELEDM 425
E+ Q + +L+ F E+ E ++ +QQME++ + + +E+ +R E E+
Sbjct: 2492 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2551
Query: 426 YLKLQEALED-ERQARQDEETVRKLQARLLEE----ESSKRAEL---EKWHLEQQQAIQT 477
+ QE L+ E+Q RQ EE + + RL E+ E RA L E+ Q A +T
Sbjct: 2552 VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2611
Query: 478 TEAEKQELEN--------------QRVLKEQALQEA----MEQLEQL--------ELERK 511
+ L+ +R + Q LQEA E+L++L EL R+
Sbjct: 2612 LPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARR 2671
Query: 512 QALEQYEEVKKKLEMATNKTKSWKDKVAHHEGLIR-LIEPGS 552
+ + Y ++ + +A K+ +K++ + L R L+ PG+
Sbjct: 2672 EDVRHY--LQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGT 2711
Score = 51.2 bits (121), Expect = 3e-06
Identities = 55/215 (25%), Positives = 100/215 (46%), Gaps = 14/215 (6%)
Query: 322 RRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEE--AASRAAEEEKKRLQT 379
R K+ ++ L E+ E +Q+ E A QE +R+ EE A RA E+ + +
Sbjct: 2243 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2302
Query: 380 QVELQARFSTELEREKLIRQQMEEQVAQKSSEL-EQYLQRVRELEDMYLKLQEALEDERQ 438
Q +A T L+ E + QQ +E +++ L E Q ++L + Q LE ERQ
Sbjct: 2303 QAVQEA---TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2359
Query: 439 ARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQE 498
RQ E + + +L + AE+ + ++ Q + +E+ + E A QE
Sbjct: 2360 -RQLEMSAEAERLKL------RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE 2412
Query: 499 AMEQLEQLELERKQALEQYEEVKKKL-EMATNKTK 532
+ ++ LE++R+Q+ E +++ + E+ K K
Sbjct: 2413 KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK 2447
Score = 48.9 bits (115), Expect = 1e-05
Identities = 48/198 (24%), Positives = 87/198 (43%), Gaps = 2/198 (1%)
Query: 342 KELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQM 401
+E+ A+E + +E +AV L E A + K+L+ Q E Q L E Q++
Sbjct: 1088 EEVLRAHEEQLKEAQAVPATLPEL--EATKASLKKLRAQAEAQQPTFDALRDELRGAQEV 1145
Query: 402 EEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKR 461
E++ Q+ E + ++R RE L+ +A+ + RQ E Q R E +
Sbjct: 1146 GERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPL 1205
Query: 462 AELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVK 521
+ +Q+ IQ + +++ +EQAL E +E+ + E ++ +QY
Sbjct: 1206 GAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAI 1265
Query: 522 KKLEMATNKTKSWKDKVA 539
K E+ K+ + VA
Sbjct: 1266 KDYELQLVTYKAQLEPVA 1283
Score = 35.4 bits (80), Expect = 0.15
Identities = 38/145 (26%), Positives = 63/145 (43%), Gaps = 21/145 (14%)
Query: 323 RKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVE 382
+KE + E E E+++KELQ A + +E R +E Q
Sbjct: 640 KKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESF--------------QAA 685
Query: 383 LQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQD 442
LQ ++S L+ I ++E A Q+ VRE E KLQEAL + +
Sbjct: 686 LQTQWSWMLQLCCCIEAHLKENAAYF-----QFFSDVREAEGQLQKLQEALR-RKYSCDR 739
Query: 443 EETVRKLQARLLEEESSKRAELEKW 467
TV +L+ LL++ ++ +L ++
Sbjct: 740 SATVTRLE-DLLQDAQDEKEQLNEY 763
Score = 30.4 bits (67), Expect = 4.7
Identities = 52/219 (23%), Positives = 85/219 (38%), Gaps = 23/219 (10%)
Query: 311 GSPPPHKEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAA 370
G P + E +QR R QL L K +A E EL+A +
Sbjct: 3173 GEPATYGELQQR---CRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEVPV 3229
Query: 371 EEEKKRLQTQVEL-QARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKL 429
K R T EL + + T +R++L+RQ +V +E + L
Sbjct: 3230 GGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVT---------------VEKVIKIL 3274
Query: 430 QEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQR 489
+E+ RQ+ + L+A + E L + EQ + +TT + EL + R
Sbjct: 3275 ITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVR 3334
Query: 490 VLKEQALQEAMEQLEQLELERKQALEQYEEVKKKLEMAT 528
L + + A LE + K+ + YE +++ L AT
Sbjct: 3335 TLLQGSGCLAGIYLE----DTKEKVSIYEAMRRGLLRAT 3369
Score = 30.4 bits (67), Expect = 4.7
Identities = 23/92 (25%), Positives = 44/92 (47%), Gaps = 5/92 (5%)
Query: 438 QARQDEETVRKLQARLLEEE---SSKRAELEKWHLEQQQAIQTTEAEKQELENQ--RVLK 492
Q +EET R + ++ S + + W + Q I + + + Q RV K
Sbjct: 3542 QVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTK 3601
Query: 493 EQALQEAMEQLEQLELERKQALEQYEEVKKKL 524
E+ + +E +E+ E+ R+Q L Y+ V+++L
Sbjct: 3602 ERMIIIIIEIIEKTEIIRQQGLASYDYVRRRL 3633
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 77.4 bits (189), Expect = 3e-14
Identities = 65/230 (28%), Positives = 116/230 (50%), Gaps = 16/230 (6%)
Query: 317 KEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKR 376
K+A + ++L + +LA QE++ ++ L+ + + E +R+ + E E EK++
Sbjct: 2435 KQAEEIGEKLHRTELATQEKVTL-VQTLEIQRQQSDHDAERLREAIAEL-----EREKEK 2488
Query: 377 LQTQVELQARFSTELEREKLIRQQMEEQVAQKS--SELEQYLQRVRELEDMYLKLQEALE 434
LQ + +L S E++ + + E Q Q+S SE + LQR R +E KL++ +
Sbjct: 2489 LQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQ 2548
Query: 435 DE-RQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQA---IQTTEAEKQELENQRV 490
DE +A+Q E ++ Q ++ +E A +E+ Q +A ++ + E Q+LE QR
Sbjct: 2549 DEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRR 2608
Query: 491 LKEQAL----QEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSWKD 536
+E+ L Q EQL+ LE + + AL EEV AT + +D
Sbjct: 2609 QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRD 2658
Score = 73.6 bits (179), Expect = 5e-13
Identities = 66/236 (27%), Positives = 113/236 (47%), Gaps = 31/236 (13%)
Query: 320 RQRRKELRKKQLAEQEELERQMKELQAANESKQ--QELEAVRKKLEEAASRAAEEEKKRL 377
RQ + E ++K+ AE E R E +AA E ++ Q LE +R + EEA R + E +R
Sbjct: 1528 RQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1587
Query: 378 Q------------TQVELQARFSTELEREKLIRQQMEEQ---VAQKSSELEQYLQRV--- 419
+ + ELQ++ ++ E+ + + ++E+ VAQ E E+ Q+
Sbjct: 1588 RQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA 1647
Query: 420 --------RELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQ 471
RELE LK EAL QA + + QA +++ E + +
Sbjct: 1648 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1707
Query: 472 QQAIQTTEAEKQELENQRVLKEQALQE---AMEQLEQLELERKQALEQYEEVKKKL 524
+QA++ E +QELE QR L E Q+ A ++L +L E +Q +Q + ++++L
Sbjct: 1708 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1763
Score = 73.2 bits (178), Expect = 6e-13
Identities = 76/285 (26%), Positives = 140/285 (49%), Gaps = 50/285 (17%)
Query: 287 SASDKKKKQEW---IQAIHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQ---EELERQ 340
+A+ +K+QE + + + + +L +E+R ++ +++ AE EL +
Sbjct: 1770 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1829
Query: 341 MKELQA-ANESKQQELEAVRKKLEEAASRAAEEEK------------KRLQTQVELQARF 387
L+A A E+K+Q A E+AA + AE E+ RL+T+ E+ +
Sbjct: 1830 AARLRALAEEAKRQRQLAE----EDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK- 1884
Query: 388 STELEREKL---------IRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDE-- 436
E E E+L R+++EEQ AQ +++E+ L ++R+ D L+ Q+ L ++
Sbjct: 1885 EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTL 1944
Query: 437 RQARQDEETVRKLQARLLEEESSKRAELE----KWHLEQQQAIQTTEAEKQELENQRVL- 491
RQ RQ EE + L+A E+ ++ +AELE + + +++ E + E QR L
Sbjct: 1945 RQRRQVEEEILALKAS-FEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 2003
Query: 492 ---------KEQALQEAMEQLEQLELERKQALEQYEEVKKKLEMA 527
E+ +Q+++ E+ +RK ALE+ E +K K+E A
Sbjct: 2004 AEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2048
Score = 70.9 bits (172), Expect = 3e-12
Identities = 69/264 (26%), Positives = 130/264 (49%), Gaps = 15/264 (5%)
Query: 291 KKKKQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQEELERQMKELQAA--N 348
+++ + W + + L +++ + + ++K+ AE+E R E QA
Sbjct: 1655 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQR 1714
Query: 349 ESKQQELEAVRKKLEEAASR--AAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVA 406
E +QELE R+ E A + AAE+E RL+ + E Q +L E+L R Q E A
Sbjct: 1715 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE-QGEQQRQLLEEELARLQREAAAA 1773
Query: 407 -QKSSELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQA-----RLLEEESSK 460
QK ELE L +VR ++ L + E+E ++ E++ ++L+A R L EE+++
Sbjct: 1774 TQKRQELEAELAKVRAEMEVLLASKARAEEESRS-TSEKSKQRLEAEAGRFRELAEEAAR 1832
Query: 461 RAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQ--ALQEAMEQLEQLELERKQALEQYE 518
L + ++Q+ + +A +Q E +RVL E+ A+ EA + E+ K+ + E
Sbjct: 1833 LRALAE-EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE 1891
Query: 519 EVKKKLEMATNKTKSWKDKVAHHE 542
+++ E + + +++ A H+
Sbjct: 1892 RLRRLAEDEAFQRRRLEEQAAQHK 1915
Score = 70.9 bits (172), Expect = 3e-12
Identities = 61/272 (22%), Positives = 127/272 (46%), Gaps = 30/272 (11%)
Query: 285 EISASDKKKKQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRK-----------KQLAE 333
+++A ++++++E + + ++ + ARQR+ L + ++L E
Sbjct: 2001 QLAAEEERRRREAEERVQKSL-------AAEEEAARQRKAALEEVERLKAKVEEARRLRE 2053
Query: 334 QEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTELER 393
+ E E ++LQ A E+ Q+ L+A K A + +E ++ LQ + + + E E
Sbjct: 2054 RAEQE-SARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA 2112
Query: 394 EKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARL 453
+ ++ EE Q E Q ++V E E +L+++ E++ QAR + + +
Sbjct: 2113 ARRAAEEAEEARVQAEREAAQSRRQVEEAE----RLKQSAEEQAQARAQAQAAAEKLRKE 2168
Query: 454 LEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQA 513
E+E+++RA+ E+ L Q+QA E+E + EQ L++ + ++L R Q
Sbjct: 2169 AEQEAARRAQAEQAALRQKQAADA------EMEKHKKFAEQTLRQKAQVEQELTTLRLQ- 2221
Query: 514 LEQYEEVKKKLEMATNKTKSWKDKVAHHEGLI 545
LE+ + K L+ + K+ + A +
Sbjct: 2222 LEETDHQKNLLDEELQRLKAEATEAARQRSQV 2253
Score = 68.9 bits (167), Expect = 1e-11
Identities = 63/228 (27%), Positives = 114/228 (50%), Gaps = 35/228 (15%)
Query: 320 RQRRKELRKKQLAEQEELERQMKELQAANESKQQ-----------ELEAVRKK------L 362
R R +E ++ QEE ER +++Q ++ K+Q E EA R+K L
Sbjct: 1506 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1565
Query: 363 EEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVREL 422
EE +A E E++ Q +VE + LE + R E ++++S E+ Q R L
Sbjct: 1566 EELRLQAEEAERRLRQAEVERARQVQVALETAQ--RSAEAELQSKRASFAEKTAQLERSL 1623
Query: 423 EDMYLKLQEALED-ERQARQD-------EETVRKLQARLLEEESSKRAELEKWHLEQQQA 474
++ ++ + + E+ ER+A+Q EE R+L+ L+ + R L+ + QQ++
Sbjct: 1624 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS 1683
Query: 475 IQTTEAEKQELENQRVLK------EQALQEAMEQLEQLELERKQALEQ 516
+ EAEKQ+ E +R + EQA+++ +L + ELE+++ L +
Sbjct: 1684 LAQAEAEKQKEEAEREARRRGKAEEQAVRQ--RELAEQELEKQRQLAE 1729
Score = 68.9 bits (167), Expect = 1e-11
Identities = 73/244 (29%), Positives = 118/244 (48%), Gaps = 25/244 (10%)
Query: 308 LKLGSPPPHKEARQRRKE------LRKKQLAEQEELERQMKELQAANESKQQELEAVRKK 361
L+LG + E R KE R++QLA +EE R+ E + +S E EA R++
Sbjct: 1973 LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE-ERVQKSLAAEEEAARQR 2031
Query: 362 ---LEEAAS-RAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQ------VAQKSSE 411
LEE +A EE +RL+ + E ++ +L +E ++ E+ V QK E
Sbjct: 2032 KAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE 2091
Query: 412 LEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQ 471
L+Q LQ+ + + D +L+ E R+A ++ E R +QA E + R ++E+ +
Sbjct: 2092 LQQTLQQEQSVLD---QLRGEAEAARRAAEEAEEAR-VQAE--REAAQSRRQVEEAERLK 2145
Query: 472 QQAIQTTEAEKQELENQRVLKEQALQEAME--QLEQLELERKQALEQYEEVKKKLEMATN 529
Q A + +A Q L+++A QEA Q EQ L +KQA + E KK T
Sbjct: 2146 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2205
Query: 530 KTKS 533
+ K+
Sbjct: 2206 RQKA 2209
Score = 65.9 bits (159), Expect = 1e-10
Identities = 82/296 (27%), Positives = 136/296 (45%), Gaps = 29/296 (9%)
Query: 317 KEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKR 376
+ A+Q+ + R ++ AE+E Q+K +A Q E A +K L +A + +EE +R
Sbjct: 1639 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1698
Query: 377 ---LQTQVELQARFSTELEREKLIRQ-QMEEQVAQKSSELEQYLQRVRELEDMYLKLQEA 432
+ + E QA EL ++L +Q Q+ E AQ+ EQ L R+R + + ++
Sbjct: 1699 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1758
Query: 433 LEDERQARQDEETVRKLQARLLEEESSK-RAELEKWHLEQQQAIQ----TTEAEKQELEN 487
LE+E Q E + + LE E +K RAE+E + +A + T+E KQ LE
Sbjct: 1759 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1818
Query: 488 Q----RVLKEQALQ---EAMEQLEQLELERKQALEQYEEVKKKL-----------EMATN 529
+ R L E+A + A E Q +L + A Q E ++ L + T
Sbjct: 1819 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE 1878
Query: 530 KTKSWKDKVAHHEGLIRLIEPGSKNPHLITNWGPAAFTEAELEEREKNWKEKKTTE 585
+ K+K A +E L RL E + + AA +A++EER ++ +E
Sbjct: 1879 AEIALKEKEAENERLRRLAEDEAFQRRRLEE--QAAQHKADIEERLAQLRKASDSE 1932
Score = 63.5 bits (153), Expect = 5e-10
Identities = 55/211 (26%), Positives = 100/211 (47%), Gaps = 23/211 (10%)
Query: 328 KKQLAEQEELERQMKELQAANES-----KQQELEAVRKKLEEAASRAAEEEKKRLQTQVE 382
+K A + ELE ++ +++ E +Q ELEA R++ AAEEE++R + +
Sbjct: 1962 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR-----QLAAEEERRRREAEER 2016
Query: 383 LQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQD 442
+Q + E EE Q+ + LE+ ++R++ + +L+E E E ARQ
Sbjct: 2017 VQKSLAAE-----------EEAARQRKAALEE-VERLKAKVEEARRLRERAEQE-SARQL 2063
Query: 443 EETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQ 502
+ Q RL EE + +++ E QQ +Q ++ +L + +A +EA E
Sbjct: 2064 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA 2123
Query: 503 LEQLELERKQALEQYEEVKKKLEMATNKTKS 533
Q E E Q+ Q EE ++ + A + ++
Sbjct: 2124 RVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2154
Score = 62.0 bits (149), Expect = 1e-09
Identities = 54/212 (25%), Positives = 111/212 (52%), Gaps = 16/212 (7%)
Query: 317 KEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEE-EKK 375
+EA Q+R + +K A ++++ +ELQ + +Q L+ +R + E AA RAAEE E+
Sbjct: 2067 QEAAQKRLQAEEK--AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE-AARRAAEEAEEA 2123
Query: 376 RLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALED 435
R+Q + E A+ ++E + ++Q EEQ AQ ++ + +++R+ + E
Sbjct: 2124 RVQAERE-AAQSRRQVEEAERLKQSAEEQ-AQARAQAQAAAEKLRK--------EAEQEA 2173
Query: 436 ERQARQDEETVRKLQARLLEEESSKR--AELEKWHLEQQQAIQTTEAEKQELENQRVLKE 493
R+A+ ++ +R+ QA E E K+ + + + +Q + T + +E ++Q+ L +
Sbjct: 2174 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2233
Query: 494 QALQEAMEQLEQLELERKQALEQYEEVKKKLE 525
+ LQ + + +R Q E+ V+ ++E
Sbjct: 2234 EELQRLKAEATEAARQRSQVEEELFSVRVQME 2265
Score = 62.0 bits (149), Expect = 1e-09
Identities = 61/249 (24%), Positives = 119/249 (47%), Gaps = 43/249 (17%)
Query: 317 KEAR---QRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEE 373
+EAR +R ++Q+ E E L++ +E A Q E +RK+ E+ A+R A+ E
Sbjct: 2121 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2180
Query: 374 KKRLQ------TQVELQARFSTELEREKL--------IRQQMEEQVAQKSSELEQYLQRV 419
+ L+ ++E +F+ + R+K +R Q+EE QK+ L++ LQR+
Sbjct: 2181 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL-LDEELQRL 2239
Query: 420 RELEDMYLKLQEALEDER-QARQDEETVRKLQARL------------------LEEESSK 460
+ + + +E+E R E + KL+AR+ L+EE+ K
Sbjct: 2240 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2299
Query: 461 RA----ELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQA--L 514
E + + Q+A + + +++L QR L E+ L+E M+ +++ + +A L
Sbjct: 2300 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2359
Query: 515 EQYEEVKKK 523
+Q +E+ ++
Sbjct: 2360 QQQKELAQE 2368
Score = 59.7 bits (143), Expect = 7e-09
Identities = 70/267 (26%), Positives = 111/267 (41%), Gaps = 17/267 (6%)
Query: 318 EARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRL 377
+A + KEL+++ E E + Q S Q+EL+ +R+ E AE + K
Sbjct: 1412 QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE------AEIQAKAR 1465
Query: 378 QTQVELQARFSTELEREKLIRQQMEEQVAQKSS---ELEQYLQRVRELEDMYLKLQEALE 434
Q + ++R E E +++R Q+E Q+ EL+ R E E + QE E
Sbjct: 1466 QAEAAERSRLRIE-EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1524
Query: 435 DERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQ 494
R+ QD E+ RK QA +E S +AE E E+Q+A+Q E + + E Q
Sbjct: 1525 RLRRQVQD-ESQRKRQAE-VELASRVKAEAEAAR-EKQRALQALEELRLQAEEAERRLRQ 1581
Query: 495 ALQEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSWKDKVAHHEGLIRLIEPGSKN 554
A E Q+ Q+ LE Q + E K+ A + + H + +L E +
Sbjct: 1582 AEVERARQV-QVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1640
Query: 555 PHLITNWGPAAFTEAELEEREKNWKEK 581
A E E + W+ K
Sbjct: 1641 AQ---QQAEAERAREEAERELERWQLK 1664
Score = 59.3 bits (142), Expect = 9e-09
Identities = 49/217 (22%), Positives = 105/217 (48%), Gaps = 19/217 (8%)
Query: 331 LAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTE 390
L EE ER ++ +A + E+EA +K + A A+ + + + ELQ R E
Sbjct: 1368 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1427
Query: 391 LEREKLIRQQMEEQVAQKSSELEQYLQRVRELE--DMYLKLQEALEDERQARQDEETVRK 448
+ R R++ Q+ +++ LQ++R+ ++ K ++A ER + EE +R
Sbjct: 1428 VVR----REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1483
Query: 449 LQARLLEEESSK----------RAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQE 498
++ +L E + RA E+ +++QA + E +++++++ K QA E
Sbjct: 1484 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1543
Query: 499 AMEQLE---QLELERKQALEQYEEVKKKLEMATNKTK 532
+++ + E+++AL+ EE++ + E A + +
Sbjct: 1544 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR 1580
Score = 59.3 bits (142), Expect = 9e-09
Identities = 65/229 (28%), Positives = 123/229 (53%), Gaps = 34/229 (14%)
Query: 319 ARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAA------SRAAEE 372
A +++++L + + + ER+ KELQ ++ + E VR+ EEAA R+ +E
Sbjct: 1395 ALEKQRQLAEAHAQAKAQAEREAKELQ-----QRMQEEVVRR--EEAAVDAQQQKRSIQE 1447
Query: 373 EKKRLQ--TQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVR-----ELEDM 425
E ++L+ ++ E+QA+ + + E + R ++EE++ +LE +R R EL+ +
Sbjct: 1448 ELQQLRQSSEAEIQAK-ARQAEAAERSRLRIEEEIRVVRLQLEA-TERQRGGAEGELQAL 1505
Query: 426 YLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQEL 485
+ +EA +RQA+++ E +R R +++ES ++ + E +E ++ EAE
Sbjct: 1506 RARAEEAEAQKRQAQEEAERLR----RQVQDESQRKRQAE---VELASRVK-AEAEAAR- 1556
Query: 486 ENQRVLKEQALQEAMEQLEQLELERKQA-LEQYEEVKKKLEMATNKTKS 533
E QR L QAL+E Q E+ E +QA +E+ +V+ LE A ++
Sbjct: 1557 EKQRAL--QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1603
Score = 58.5 bits (140), Expect = 2e-08
Identities = 55/241 (22%), Positives = 107/241 (44%), Gaps = 13/241 (5%)
Query: 299 QAIHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQE--ELERQMKELQAANESKQQELE 356
QA + + + K + + LR+K EQE L Q++E +EL+
Sbjct: 2178 QAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2237
Query: 357 AVRKKLEEAASRAAEEEKKRLQTQVELQ----ARFSTELEREKLIRQQMEEQVAQKSSEL 412
++ + EAA + ++ E++ +V+++ + E E LI + + E
Sbjct: 2238 RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEA 2297
Query: 413 EQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEE-----ESSKRAELEKW 467
E+ Q E + + QEA + A +D R L ++L+E + + R + E
Sbjct: 2298 EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE 2357
Query: 468 HLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVKK-KLEM 526
L+QQ+ + +A + + E++ + +Q +E LE ER++ LE E ++ KL +
Sbjct: 2358 LLQQQKELAQEQARRLQ-EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRV 2416
Query: 527 A 527
A
Sbjct: 2417 A 2417
Score = 58.2 bits (139), Expect = 2e-08
Identities = 53/204 (25%), Positives = 97/204 (47%), Gaps = 13/204 (6%)
Query: 335 EELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTELERE 394
E L R +E + A + + +E R++L E A EK+R + QA+ E E +
Sbjct: 1366 ETLRRMEEEERLAEQQRAEE----RERLAEVE---AALEKQRQLAEAHAQAKAQAEREAK 1418
Query: 395 KLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQAR-QDEETVRKLQARL 453
+L +Q+M+E+V ++ Q+ R +++ +L+++ E E QA+ + E + + R+
Sbjct: 1419 EL-QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1477
Query: 454 LEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELE---- 509
EE R +LE ++ A +A + E K QA +EA Q++ E
Sbjct: 1478 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1537
Query: 510 RKQALEQYEEVKKKLEMATNKTKS 533
R+ +E VK + E A K ++
Sbjct: 1538 RQAEVELASRVKAEAEAAREKQRA 1561
Score = 55.8 bits (133), Expect = 1e-07
Identities = 48/235 (20%), Positives = 109/235 (46%), Gaps = 15/235 (6%)
Query: 290 DKKKKQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQEELERQMKELQAANE 349
D +++QE IQA+ P +++ R++LR++Q A EE+ER ++++
Sbjct: 1252 DARRRQEQIQAM-------------PLADSQAVREQLRQEQ-ALLEEIERHGEKVEECQR 1297
Query: 350 SKQQELEAVRK-KLEEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQK 408
+Q + A++ +L+ +A E + ++Q+ + ++ +R E
Sbjct: 1298 FAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLT 1357
Query: 409 SSELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWH 468
S ++ + +R +E+ ++ +ER+ + E + Q +L E + +A+ E+
Sbjct: 1358 SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA 1417
Query: 469 LEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVKKK 523
E QQ +Q ++E +++++QE ++QL Q QA + E ++
Sbjct: 1418 KELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1472
Score = 55.5 bits (132), Expect = 1e-07
Identities = 69/252 (27%), Positives = 118/252 (46%), Gaps = 32/252 (12%)
Query: 318 EARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAAS--RAAEEEKK 375
EA QRR+ L ++ + ++E ++ +L+ A++S ELE + +E+ R EEE
Sbjct: 1900 EAFQRRR-LEEQAAQHKADIEERLAQLRKASDS---ELERQKGLVEDTLRQRRQVEEEIL 1955
Query: 376 RLQTQVELQARFSTELEREK-LIRQQMEEQVAQKS-SELEQYLQRV---------RELED 424
L+ E A ELE E IR E+ + K +ELE QR RE E+
Sbjct: 1956 ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 2015
Query: 425 MYLKLQEALEDERQARQDE----ETVRKLQARLLE----EESSKRAELEKWHLEQQQAIQ 476
++Q++L E +A + E V +L+A++ E E +++ + L Q+ A +
Sbjct: 2016 ---RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK 2072
Query: 477 TTEAEKQELENQRVLKEQALQEAMEQ----LEQLELERKQALEQYEEVKKKLEMATNKTK 532
+AE++ KEQ LQ+ ++Q L+QL E + A EE ++ A +
Sbjct: 2073 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAA 2132
Query: 533 SWKDKVAHHEGL 544
+ +V E L
Sbjct: 2133 QSRRQVEEAERL 2144
Score = 54.7 bits (130), Expect = 2e-07
Identities = 68/237 (28%), Positives = 116/237 (48%), Gaps = 44/237 (18%)
Query: 322 RRKELRKKQLAEQEEL-ERQMKE-LQAANESKQQELEAV----RKKLEEAASRAAEEEKK 375
R ++L ++ LA+Q L E+ +KE +QA E+ + + EA +K+L + +R +E+K+
Sbjct: 2319 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2378
Query: 376 RLQTQVELQAR-FSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALE 434
++ Q+ + + F LE E+ ++Q+E S+E E+ RV E+ + +E +
Sbjct: 2379 QMAQQLAEETQGFQRTLEAER--QRQLE-----MSAEAERLKLRVAEMSRAQARAEE--D 2429
Query: 435 DERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQ----------AIQTTEAEKQE 484
+R +Q EE KL L + K ++ +++QQ AI E EK++
Sbjct: 2430 AQRFRKQAEEIGEKLHRTELATQE-KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK 2488
Query: 485 L------------ENQRVLKEQALQEAMEQLEQLELERKQALEQ----YEEVKKKLE 525
L E Q V +EQ LQE + L+Q L K +L Q E+ K KLE
Sbjct: 2489 LQQEAKLLQLKSEEMQTVQQEQLLQET-QALQQSFLSEKDSLLQRERFIEQEKAKLE 2544
Score = 53.9 bits (128), Expect = 4e-07
Identities = 69/282 (24%), Positives = 128/282 (45%), Gaps = 52/282 (18%)
Query: 321 QRRKELRKKQLAEQEELERQMKELQAANESKQ--------QELEAVRKKLEEAASRAAEE 372
+R +E + E+E+L+++ K LQ +E Q QE +A+++ +
Sbjct: 2473 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2532
Query: 373 EKKRLQTQVELQARFSTEL-------EREKLIRQQMEEQVAQKSSELEQYLQRVRELEDM 425
E+ Q + +L+ F E+ E ++ +QQME++ + + +E+ +R E E+
Sbjct: 2533 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2592
Query: 426 YLKLQEALED-ERQARQDEETVRKLQARLLEE----ESSKRAEL---EKWHLEQQQAIQT 477
+ QE L+ E+Q RQ EE + + RL E+ E RA L E+ Q A +T
Sbjct: 2593 VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2652
Query: 478 TEAEKQELEN--------------QRVLKEQALQEA----MEQLEQL--------ELERK 511
+ L+ +R + Q LQEA E+L++L EL R+
Sbjct: 2653 LPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARR 2712
Query: 512 QALEQYEEVKKKLEMATNKTKSWKDKVAHHEGLIR-LIEPGS 552
+ + Y ++ + +A K+ +K++ + L R L+ PG+
Sbjct: 2713 EDVRHY--LQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGT 2752
Score = 51.2 bits (121), Expect = 3e-06
Identities = 55/215 (25%), Positives = 100/215 (46%), Gaps = 14/215 (6%)
Query: 322 RRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEE--AASRAAEEEKKRLQT 379
R K+ ++ L E+ E +Q+ E A QE +R+ EE A RA E+ + +
Sbjct: 2284 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2343
Query: 380 QVELQARFSTELEREKLIRQQMEEQVAQKSSEL-EQYLQRVRELEDMYLKLQEALEDERQ 438
Q +A T L+ E + QQ +E +++ L E Q ++L + Q LE ERQ
Sbjct: 2344 QAVQEA---TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2400
Query: 439 ARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQE 498
RQ E + + +L + AE+ + ++ Q + +E+ + E A QE
Sbjct: 2401 -RQLEMSAEAERLKL------RVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE 2453
Query: 499 AMEQLEQLELERKQALEQYEEVKKKL-EMATNKTK 532
+ ++ LE++R+Q+ E +++ + E+ K K
Sbjct: 2454 KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK 2488
Score = 48.9 bits (115), Expect = 1e-05
Identities = 48/198 (24%), Positives = 87/198 (43%), Gaps = 2/198 (1%)
Query: 342 KELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQM 401
+E+ A+E + +E +AV L E A + K+L+ Q E Q L E Q++
Sbjct: 1129 EEVLRAHEEQLKEAQAVPATLPEL--EATKASLKKLRAQAEAQQPTFDALRDELRGAQEV 1186
Query: 402 EEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKR 461
E++ Q+ E + ++R RE L+ +A+ + RQ E Q R E +
Sbjct: 1187 GERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPL 1246
Query: 462 AELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVK 521
+ +Q+ IQ + +++ +EQAL E +E+ + E ++ +QY
Sbjct: 1247 GAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAI 1306
Query: 522 KKLEMATNKTKSWKDKVA 539
K E+ K+ + VA
Sbjct: 1307 KDYELQLVTYKAQLEPVA 1324
Score = 35.4 bits (80), Expect = 0.15
Identities = 38/145 (26%), Positives = 63/145 (43%), Gaps = 21/145 (14%)
Query: 323 RKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVE 382
+KE + E E E+++KELQ A + +E R +E Q
Sbjct: 681 KKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESF--------------QAA 726
Query: 383 LQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQD 442
LQ ++S L+ I ++E A Q+ VRE E KLQEAL + +
Sbjct: 727 LQTQWSWMLQLCCCIEAHLKENAAYF-----QFFSDVREAEGQLQKLQEALR-RKYSCDR 780
Query: 443 EETVRKLQARLLEEESSKRAELEKW 467
TV +L+ LL++ ++ +L ++
Sbjct: 781 SATVTRLE-DLLQDAQDEKEQLNEY 804
Score = 30.4 bits (67), Expect = 4.7
Identities = 52/219 (23%), Positives = 85/219 (38%), Gaps = 23/219 (10%)
Query: 311 GSPPPHKEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAA 370
G P + E +QR R QL L K +A E EL+A +
Sbjct: 3214 GEPATYGELQQR---CRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEVPV 3270
Query: 371 EEEKKRLQTQVEL-QARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKL 429
K R T EL + + T +R++L+RQ +V +E + L
Sbjct: 3271 GGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVT---------------VEKVIKIL 3315
Query: 430 QEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQR 489
+E+ RQ+ + L+A + E L + EQ + +TT + EL + R
Sbjct: 3316 ITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVR 3375
Query: 490 VLKEQALQEAMEQLEQLELERKQALEQYEEVKKKLEMAT 528
L + + A LE + K+ + YE +++ L AT
Sbjct: 3376 TLLQGSGCLAGIYLE----DTKEKVSIYEAMRRGLLRAT 3410
Score = 30.4 bits (67), Expect = 4.7
Identities = 23/92 (25%), Positives = 44/92 (47%), Gaps = 5/92 (5%)
Query: 438 QARQDEETVRKLQARLLEEE---SSKRAELEKWHLEQQQAIQTTEAEKQELENQ--RVLK 492
Q +EET R + ++ S + + W + Q I + + + Q RV K
Sbjct: 3583 QVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTK 3642
Query: 493 EQALQEAMEQLEQLELERKQALEQYEEVKKKL 524
E+ + +E +E+ E+ R+Q L Y+ V+++L
Sbjct: 3643 ERMIIIIIEIIEKTEIIRQQGLASYDYVRRRL 3674
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 77.4 bits (189), Expect = 3e-14
Identities = 72/259 (27%), Positives = 131/259 (50%), Gaps = 47/259 (18%)
Query: 317 KEARQRRKELRKKQLAEQ-------EELERQMKELQAANESKQQELEAVRKKLEEAASRA 369
++ RQR + LR+K+ AEQ E+ R+++E++ E + +++ R+++E+
Sbjct: 536 EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMK--- 592
Query: 370 AEEEKKRLQ---------TQVELQARFSTELEREKLIRQQMEEQVAQKSSELE----QYL 416
EE+KK+++ T+ + R + E ++K ++MEE A++ E E ++L
Sbjct: 593 -EEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWL 651
Query: 417 QRVRE-----------LEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELE 465
Q+ E E+ +L++A E +R A Q E+ R+ + R E +R E E
Sbjct: 652 QQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQE 711
Query: 466 KWHLEQQQAIQTTEAEKQELENQRVL--KEQALQEAMEQLEQLELERKQALEQ------- 516
+ E+Q A Q E++ L+ +R L +E+AL+ EQL Q ELE K+ E+
Sbjct: 712 RREQERQLAEQERRREQERLQAERELQEREKALRLQKEQL-QRELEEKKKKEEQQRLAER 770
Query: 517 --YEEVKKKLEMATNKTKS 533
EE +KK + A +K+
Sbjct: 771 QLQEEQEKKAKEAAGASKA 789
Score = 57.4 bits (137), Expect = 4e-08
Identities = 50/187 (26%), Positives = 82/187 (43%), Gaps = 22/187 (11%)
Query: 263 ESLPDKDGKKCLFLVKCFDKTFEISASDKKKKQEWIQAIHSTIHLLKLGSPPPHKEARQR 322
E L ++ KK K + ++ ++ W+Q +L +E +
Sbjct: 616 ERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERL 675
Query: 323 RKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLE-EAASRAAEEEKKRLQTQV 381
RK K+LAEQ E ER+ +E + +Q+ E R++ E + A + E++RLQ +
Sbjct: 676 RKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAER 735
Query: 382 ELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQ 441
ELQ EREK +R Q E Q RELE+ K ++ ERQ ++
Sbjct: 736 ELQ-------EREKALRLQKE--------------QLQRELEEKKKKEEQQRLAERQLQE 774
Query: 442 DEETVRK 448
++E K
Sbjct: 775 EQEKKAK 781
Score = 51.2 bits (121), Expect = 3e-06
Identities = 57/243 (23%), Positives = 116/243 (47%), Gaps = 29/243 (11%)
Query: 311 GSPPPHKEARQRRK------ELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEE 364
G P + AR++R EL ++Q E EEL+ + ++ + + +R L
Sbjct: 439 GPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLHT 498
Query: 365 -----------AASRAAEEEKKRLQTQVELQARFS-TELEREKLIRQQMEEQVAQKSSEL 412
+A R+ + + T + + + S E ER++L + +E+ Q +
Sbjct: 499 VQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQK 558
Query: 413 EQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEE----SSKRAELEKWH 468
+ +R R LE++ LK +E L QAR+ E +++ + + +E++ K + ++
Sbjct: 559 VEEDKR-RRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEER 617
Query: 469 LEQQQAIQTTEAEK-QELENQRVLKEQA-----LQEAMEQLEQLELERKQALEQYEEVKK 522
L +++A + A+K +E+E +R +E+A LQ+ E+ EL +K+ E+ E ++K
Sbjct: 618 LAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRK 677
Query: 523 KLE 525
E
Sbjct: 678 AAE 680
Score = 44.3 bits (103), Expect = 3e-04
Identities = 63/297 (21%), Positives = 123/297 (41%), Gaps = 53/297 (17%)
Query: 314 PPHKEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEA---ASRAA 370
PP R+R + +L E++ LE +EL+ R K + AS+
Sbjct: 443 PPQSARRKRSYKQAVSELDEEQHLE-------------DEELQPPRSKTPSSPCPASKVV 489
Query: 371 EEEKKRLQT----QVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMY 426
+ L T Q+ + + + I++ ++ K S +E+ QR+ L
Sbjct: 490 RPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLENLR--- 546
Query: 427 LKLQEALEDERQARQDEETVRKLQARLLEEESSKRA-----------ELEKWHLEQQ--Q 473
+ +EA + RQ ++++ R + +L EE ++ E +K +EQ+ Q
Sbjct: 547 -RKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQ 605
Query: 474 AIQTTEAEKQELENQRVLKEQALQEAMEQLE-----QLELERKQALEQYEEVKKKLEMAT 528
+ TE K+E + K++A + ME++E + E R + L+Q EE ++ E+
Sbjct: 606 IDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQ 665
Query: 529 NKTKSWKDKVAHHEGLIRLIEPGSKNPHLITNWGPAAFTEAELEEREKNWKEKKTTE 585
K + ++++ RL E + E E E+E+ +E++ E
Sbjct: 666 KKKEEEQERLRKAAEAKRLAEQREQERR-----------EQERREQERREQERREQE 711
>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo
sapiens]
Length = 1293
Score = 77.0 bits (188), Expect = 4e-14
Identities = 62/214 (28%), Positives = 116/214 (54%), Gaps = 24/214 (11%)
Query: 312 SPPPHKEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAE 371
+P P E Q+ ++ + +L EQE E +M+ + E K+QE +R++ EE R E
Sbjct: 712 TPGPALEQLQQLEKAKAAKL-EQERREAEMRAKREEEERKRQE--ELRRQQEEILRRQQE 768
Query: 372 EEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQE 431
EE+KR + + EL R ++E+ +R+Q E+++A + E+ Q + E+ +L+E
Sbjct: 769 EERKRREEE-ELARR-----KQEEALRRQREQEIALRRQREEEERQ---QQEEALRRLEE 819
Query: 432 ALEDERQARQDEETVRKLQARLL-----EEESSKRAELEKWHLEQQQAI---QTTEAEKQ 483
+E + R+ EE +RK + EEE+ +R E + +E++ A + E +++
Sbjct: 820 RRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRK 879
Query: 484 ELENQR----VLKEQALQEAMEQLEQLELERKQA 513
ELE QR + + Q QEA+ +L+Q + +++ A
Sbjct: 880 ELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLA 913
Score = 72.0 bits (175), Expect = 1e-12
Identities = 64/202 (31%), Positives = 105/202 (51%), Gaps = 21/202 (10%)
Query: 309 KLGSPPPHKEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASR 368
KL E R +R+E +K+ QEEL RQ +E+ +QQE E R++ EE A R
Sbjct: 730 KLEQERREAEMRAKREEEERKR---QEELRRQQEEILR----RQQEEERKRREEEELARR 782
Query: 369 AAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLK 428
EE +R + Q + +RE+ RQQ EE + + + +R R+ E++ K
Sbjct: 783 KQEEALRRQREQ-----EIALRRQREEEERQQQEEALRRLEERRREEEER-RKQEELLRK 836
Query: 429 LQEALEDERQARQDEETVRKLQA-RLLEEESSKRAELEKWHLEQQQAIQTTEAEKQ-ELE 486
+E E + AR++EE R+L+ RL EE + R H E+++ + E ++Q EL
Sbjct: 837 QEE--EAAKWAREEEEAQRRLEENRLRMEEEAARLR----HEEEERKRKELEVQRQKELM 890
Query: 487 NQRVLKEQALQEAMEQLEQLEL 508
QR +++AL+ +Q +Q +L
Sbjct: 891 RQRQQQQEALRRLQQQQQQQQL 912
Score = 67.4 bits (163), Expect = 3e-11
Identities = 67/244 (27%), Positives = 121/244 (49%), Gaps = 39/244 (15%)
Query: 317 KEARQRRKELRKKQ----LAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEE 372
+E R+R++ELR++Q +QEE ++ +E + A +++ L R++ E A R EE
Sbjct: 746 EEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQ-EIALRRQREE 804
Query: 373 EKKRLQTQV--ELQARFSTELER---EKLIRQQ--------MEEQVAQKSSE-----LEQ 414
E+++ Q + L+ R E ER E+L+R+Q EE+ AQ+ E +E+
Sbjct: 805 EERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEE 864
Query: 415 YLQRVRELED----MYLKLQEALEDERQARQDEETVRKLQARLLEEE--SSKRAELEKW- 467
R+R E+ L++Q E RQ +Q +E +R+LQ + +++ K W
Sbjct: 865 EAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWG 924
Query: 468 ------HLEQQQAIQTTEAEKQELENQRVLKEQ---ALQEAMEQLEQLELERKQALEQYE 518
+ Q + E +K E E +R L+E+ +E M+ L+Q + +++Q L +
Sbjct: 925 QQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWG 984
Query: 519 EVKK 522
V K
Sbjct: 985 NVSK 988
Score = 67.4 bits (163), Expect = 3e-11
Identities = 57/224 (25%), Positives = 114/224 (50%), Gaps = 20/224 (8%)
Query: 318 EARQRRKELRKKQLAEQEELERQMKELQA----ANESKQQELEAVRKKLEEAASRAAEEE 373
E R+R +E R+K QEEL R+ +E A E Q+ LE R ++EE A+R EE
Sbjct: 818 EERRREEEERRK----QEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEE 873
Query: 374 KKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEAL 433
++R + ++E+Q +++L+RQ+ ++Q A + + +Q Q++ +++ +
Sbjct: 874 EERKRKELEVQ-------RQKELMRQRQQQQEALRRLQQQQQQQQLAQMK-LPSSSTWGQ 925
Query: 434 EDERQARQDEETVRKLQARLLEEESSK--RAELEKWHLEQQQAIQTTEAEKQELEN--QR 489
+ A Q + T+ + + LEEE + R E + E +A+Q + ++Q+ +
Sbjct: 926 QSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGN 985
Query: 490 VLKEQALQEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKS 533
V K +++ +++Q E + Q +Q ++ ++ A N T S
Sbjct: 986 VSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHS 1029
Score = 60.8 bits (146), Expect = 3e-09
Identities = 68/266 (25%), Positives = 125/266 (46%), Gaps = 48/266 (18%)
Query: 341 MKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQ 400
+++LQ ++K +LE R++ E A R EE K+ Q EL+ ++E+++R+Q
Sbjct: 717 LEQLQQLEKAKAAKLEQERREAEMRAKREEEERKR----QEELRR------QQEEILRRQ 766
Query: 401 MEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSK 460
EE+ +K E E+ +R K +EAL +R+ R+ + R +EE+ +
Sbjct: 767 QEEE--RKRREEEELARR---------KQEEALRRQREQEIALRRQREEEERQQQEEALR 815
Query: 461 RAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQ--LELERKQA-LEQY 517
R E E+ E+++ Q KQE E + +E+ +EA +LE+ L +E + A L
Sbjct: 816 RLE-ERRREEEERRKQEELLRKQEEEAAKWAREE--EEAQRRLEENRLRMEEEAARLRHE 872
Query: 518 EEVKKKLEMATNKTKSWKDKVAHHEGLIRLIEPGSKNPHLI-------TNWG-------- 562
EE +K+ E+ + K + + +R ++ + L + WG
Sbjct: 873 EEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTAC 932
Query: 563 --PAAFTEAEL----EEREKNWKEKK 582
A + AE+ EERE+ +E++
Sbjct: 933 QSQATLSLAEIQKLEEERERQLREEQ 958
Score = 50.4 bits (119), Expect = 4e-06
Identities = 49/207 (23%), Positives = 95/207 (45%), Gaps = 32/207 (15%)
Query: 317 KEARQRRKELRKKQ-------LAEQEELERQMKELQAA------------NESKQQELEA 357
+E R++++EL +KQ E+EE +R+++E + E K++ELE
Sbjct: 824 EEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEV 883
Query: 358 VRKKLEEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQ 417
R+K + +E +RLQ Q + Q +L QQ Q + L L
Sbjct: 884 QRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLS--LA 941
Query: 418 RVRELEDMYLKLQEALEDERQARQDE-ETVRKLQARLLEEESSKRAELEKW-HLEQQQAI 475
+++LE+ E ERQ R+++ R+L L +++ ++ +L W ++ +
Sbjct: 942 EIQKLEE---------ERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGT 992
Query: 476 QTTEAEKQELENQRVLKEQALQEAMEQ 502
+ E Q+ E +++ K+Q Q+ +Q
Sbjct: 993 TKSLLEIQQEEARQMQKQQQQQQQHQQ 1019
Score = 47.8 bits (112), Expect = 3e-05
Identities = 42/175 (24%), Positives = 81/175 (46%), Gaps = 18/175 (10%)
Query: 316 HKEARQRRKELRKKQLAEQEELERQMKELQAA---NESKQQELEAVRKKLEEAASRAAEE 372
H+E ++RKEL ++ Q+EL RQ ++ Q A + +QQ+ + + KL +++ +
Sbjct: 871 HEEEERKRKEL---EVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQS 927
Query: 373 EKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEA 432
Q+Q L +LE E+ +Q+ E+ ++ EL + LQ+ ++ + Q+
Sbjct: 928 NTTACQSQATLSLAEIQKLEEER--ERQLREEQRRQQRELMKALQQQQQQQ------QQK 979
Query: 433 LEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELEN 487
L + T + LLE + + +++K +QQQ Q A N
Sbjct: 980 LSGWGNVSKPSGTTKS----LLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHSN 1030
>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo
sapiens]
Length = 1320
Score = 77.0 bits (188), Expect = 4e-14
Identities = 62/214 (28%), Positives = 116/214 (54%), Gaps = 24/214 (11%)
Query: 312 SPPPHKEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAE 371
+P P E Q+ ++ + +L EQE E +M+ + E K+QE +R++ EE R E
Sbjct: 739 TPGPALEQLQQLEKAKAAKL-EQERREAEMRAKREEEERKRQE--ELRRQQEEILRRQQE 795
Query: 372 EEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQE 431
EE+KR + + EL R ++E+ +R+Q E+++A + E+ Q + E+ +L+E
Sbjct: 796 EERKRREEE-ELARR-----KQEEALRRQREQEIALRRQREEEERQ---QQEEALRRLEE 846
Query: 432 ALEDERQARQDEETVRKLQARLL-----EEESSKRAELEKWHLEQQQAI---QTTEAEKQ 483
+E + R+ EE +RK + EEE+ +R E + +E++ A + E +++
Sbjct: 847 RRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRK 906
Query: 484 ELENQR----VLKEQALQEAMEQLEQLELERKQA 513
ELE QR + + Q QEA+ +L+Q + +++ A
Sbjct: 907 ELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLA 940
Score = 72.0 bits (175), Expect = 1e-12
Identities = 64/202 (31%), Positives = 105/202 (51%), Gaps = 21/202 (10%)
Query: 309 KLGSPPPHKEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASR 368
KL E R +R+E +K+ QEEL RQ +E+ +QQE E R++ EE A R
Sbjct: 757 KLEQERREAEMRAKREEEERKR---QEELRRQQEEILR----RQQEEERKRREEEELARR 809
Query: 369 AAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLK 428
EE +R + Q + +RE+ RQQ EE + + + +R R+ E++ K
Sbjct: 810 KQEEALRRQREQ-----EIALRRQREEEERQQQEEALRRLEERRREEEER-RKQEELLRK 863
Query: 429 LQEALEDERQARQDEETVRKLQA-RLLEEESSKRAELEKWHLEQQQAIQTTEAEKQ-ELE 486
+E E + AR++EE R+L+ RL EE + R H E+++ + E ++Q EL
Sbjct: 864 QEE--EAAKWAREEEEAQRRLEENRLRMEEEAARLR----HEEEERKRKELEVQRQKELM 917
Query: 487 NQRVLKEQALQEAMEQLEQLEL 508
QR +++AL+ +Q +Q +L
Sbjct: 918 RQRQQQQEALRRLQQQQQQQQL 939
Score = 67.4 bits (163), Expect = 3e-11
Identities = 67/244 (27%), Positives = 121/244 (49%), Gaps = 39/244 (15%)
Query: 317 KEARQRRKELRKKQ----LAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEE 372
+E R+R++ELR++Q +QEE ++ +E + A +++ L R++ E A R EE
Sbjct: 773 EEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQ-EIALRRQREE 831
Query: 373 EKKRLQTQV--ELQARFSTELER---EKLIRQQ--------MEEQVAQKSSE-----LEQ 414
E+++ Q + L+ R E ER E+L+R+Q EE+ AQ+ E +E+
Sbjct: 832 EERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEE 891
Query: 415 YLQRVRELED----MYLKLQEALEDERQARQDEETVRKLQARLLEEE--SSKRAELEKW- 467
R+R E+ L++Q E RQ +Q +E +R+LQ + +++ K W
Sbjct: 892 EAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWG 951
Query: 468 ------HLEQQQAIQTTEAEKQELENQRVLKEQ---ALQEAMEQLEQLELERKQALEQYE 518
+ Q + E +K E E +R L+E+ +E M+ L+Q + +++Q L +
Sbjct: 952 QQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWG 1011
Query: 519 EVKK 522
V K
Sbjct: 1012 NVSK 1015
Score = 67.4 bits (163), Expect = 3e-11
Identities = 57/224 (25%), Positives = 114/224 (50%), Gaps = 20/224 (8%)
Query: 318 EARQRRKELRKKQLAEQEELERQMKELQA----ANESKQQELEAVRKKLEEAASRAAEEE 373
E R+R +E R+K QEEL R+ +E A E Q+ LE R ++EE A+R EE
Sbjct: 845 EERRREEEERRK----QEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEE 900
Query: 374 KKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEAL 433
++R + ++E+Q +++L+RQ+ ++Q A + + +Q Q++ +++ +
Sbjct: 901 EERKRKELEVQ-------RQKELMRQRQQQQEALRRLQQQQQQQQLAQMK-LPSSSTWGQ 952
Query: 434 EDERQARQDEETVRKLQARLLEEESSK--RAELEKWHLEQQQAIQTTEAEKQELEN--QR 489
+ A Q + T+ + + LEEE + R E + E +A+Q + ++Q+ +
Sbjct: 953 QSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGN 1012
Query: 490 VLKEQALQEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKS 533
V K +++ +++Q E + Q +Q ++ ++ A N T S
Sbjct: 1013 VSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHS 1056
Score = 60.8 bits (146), Expect = 3e-09
Identities = 68/266 (25%), Positives = 125/266 (46%), Gaps = 48/266 (18%)
Query: 341 MKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQ 400
+++LQ ++K +LE R++ E A R EE K+ Q EL+ ++E+++R+Q
Sbjct: 744 LEQLQQLEKAKAAKLEQERREAEMRAKREEEERKR----QEELRR------QQEEILRRQ 793
Query: 401 MEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSK 460
EE+ +K E E+ +R K +EAL +R+ R+ + R +EE+ +
Sbjct: 794 QEEE--RKRREEEELARR---------KQEEALRRQREQEIALRRQREEEERQQQEEALR 842
Query: 461 RAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQ--LELERKQA-LEQY 517
R E E+ E+++ Q KQE E + +E+ +EA +LE+ L +E + A L
Sbjct: 843 RLE-ERRREEEERRKQEELLRKQEEEAAKWAREE--EEAQRRLEENRLRMEEEAARLRHE 899
Query: 518 EEVKKKLEMATNKTKSWKDKVAHHEGLIRLIEPGSKNPHLI-------TNWG-------- 562
EE +K+ E+ + K + + +R ++ + L + WG
Sbjct: 900 EEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTAC 959
Query: 563 --PAAFTEAEL----EEREKNWKEKK 582
A + AE+ EERE+ +E++
Sbjct: 960 QSQATLSLAEIQKLEEERERQLREEQ 985
Score = 50.4 bits (119), Expect = 4e-06
Identities = 49/207 (23%), Positives = 95/207 (45%), Gaps = 32/207 (15%)
Query: 317 KEARQRRKELRKKQ-------LAEQEELERQMKELQAA------------NESKQQELEA 357
+E R++++EL +KQ E+EE +R+++E + E K++ELE
Sbjct: 851 EEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEV 910
Query: 358 VRKKLEEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQ 417
R+K + +E +RLQ Q + Q +L QQ Q + L L
Sbjct: 911 QRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLS--LA 968
Query: 418 RVRELEDMYLKLQEALEDERQARQDE-ETVRKLQARLLEEESSKRAELEKW-HLEQQQAI 475
+++LE+ E ERQ R+++ R+L L +++ ++ +L W ++ +
Sbjct: 969 EIQKLEE---------ERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGT 1019
Query: 476 QTTEAEKQELENQRVLKEQALQEAMEQ 502
+ E Q+ E +++ K+Q Q+ +Q
Sbjct: 1020 TKSLLEIQQEEARQMQKQQQQQQQHQQ 1046
Score = 47.8 bits (112), Expect = 3e-05
Identities = 42/175 (24%), Positives = 81/175 (46%), Gaps = 18/175 (10%)
Query: 316 HKEARQRRKELRKKQLAEQEELERQMKELQAA---NESKQQELEAVRKKLEEAASRAAEE 372
H+E ++RKEL ++ Q+EL RQ ++ Q A + +QQ+ + + KL +++ +
Sbjct: 898 HEEEERKRKEL---EVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQS 954
Query: 373 EKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEA 432
Q+Q L +LE E+ +Q+ E+ ++ EL + LQ+ ++ + Q+
Sbjct: 955 NTTACQSQATLSLAEIQKLEEER--ERQLREEQRRQQRELMKALQQQQQQQ------QQK 1006
Query: 433 LEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELEN 487
L + T + LLE + + +++K +QQQ Q A N
Sbjct: 1007 LSGWGNVSKPSGTTKS----LLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHSN 1057
>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 77.0 bits (188), Expect = 4e-14
Identities = 62/214 (28%), Positives = 116/214 (54%), Gaps = 24/214 (11%)
Query: 312 SPPPHKEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAE 371
+P P E Q+ ++ + +L EQE E +M+ + E K+QE +R++ EE R E
Sbjct: 718 TPGPALEQLQQLEKAKAAKL-EQERREAEMRAKREEEERKRQE--ELRRQQEEILRRQQE 774
Query: 372 EEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQE 431
EE+KR + + EL R ++E+ +R+Q E+++A + E+ Q + E+ +L+E
Sbjct: 775 EERKRREEE-ELARR-----KQEEALRRQREQEIALRRQREEEERQ---QQEEALRRLEE 825
Query: 432 ALEDERQARQDEETVRKLQARLL-----EEESSKRAELEKWHLEQQQAI---QTTEAEKQ 483
+E + R+ EE +RK + EEE+ +R E + +E++ A + E +++
Sbjct: 826 RRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRK 885
Query: 484 ELENQR----VLKEQALQEAMEQLEQLELERKQA 513
ELE QR + + Q QEA+ +L+Q + +++ A
Sbjct: 886 ELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLA 919
Score = 72.0 bits (175), Expect = 1e-12
Identities = 64/202 (31%), Positives = 105/202 (51%), Gaps = 21/202 (10%)
Query: 309 KLGSPPPHKEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASR 368
KL E R +R+E +K+ QEEL RQ +E+ +QQE E R++ EE A R
Sbjct: 736 KLEQERREAEMRAKREEEERKR---QEELRRQQEEILR----RQQEEERKRREEEELARR 788
Query: 369 AAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLK 428
EE +R + Q + +RE+ RQQ EE + + + +R R+ E++ K
Sbjct: 789 KQEEALRRQREQ-----EIALRRQREEEERQQQEEALRRLEERRREEEER-RKQEELLRK 842
Query: 429 LQEALEDERQARQDEETVRKLQA-RLLEEESSKRAELEKWHLEQQQAIQTTEAEKQ-ELE 486
+E E + AR++EE R+L+ RL EE + R H E+++ + E ++Q EL
Sbjct: 843 QEE--EAAKWAREEEEAQRRLEENRLRMEEEAARLR----HEEEERKRKELEVQRQKELM 896
Query: 487 NQRVLKEQALQEAMEQLEQLEL 508
QR +++AL+ +Q +Q +L
Sbjct: 897 RQRQQQQEALRRLQQQQQQQQL 918
Score = 67.4 bits (163), Expect = 3e-11
Identities = 67/244 (27%), Positives = 121/244 (49%), Gaps = 39/244 (15%)
Query: 317 KEARQRRKELRKKQ----LAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEE 372
+E R+R++ELR++Q +QEE ++ +E + A +++ L R++ E A R EE
Sbjct: 752 EEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQ-EIALRRQREE 810
Query: 373 EKKRLQTQV--ELQARFSTELER---EKLIRQQ--------MEEQVAQKSSE-----LEQ 414
E+++ Q + L+ R E ER E+L+R+Q EE+ AQ+ E +E+
Sbjct: 811 EERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEE 870
Query: 415 YLQRVRELED----MYLKLQEALEDERQARQDEETVRKLQARLLEEE--SSKRAELEKW- 467
R+R E+ L++Q E RQ +Q +E +R+LQ + +++ K W
Sbjct: 871 EAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWG 930
Query: 468 ------HLEQQQAIQTTEAEKQELENQRVLKEQ---ALQEAMEQLEQLELERKQALEQYE 518
+ Q + E +K E E +R L+E+ +E M+ L+Q + +++Q L +
Sbjct: 931 QQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWG 990
Query: 519 EVKK 522
V K
Sbjct: 991 NVSK 994
Score = 67.4 bits (163), Expect = 3e-11
Identities = 57/224 (25%), Positives = 114/224 (50%), Gaps = 20/224 (8%)
Query: 318 EARQRRKELRKKQLAEQEELERQMKELQA----ANESKQQELEAVRKKLEEAASRAAEEE 373
E R+R +E R+K QEEL R+ +E A E Q+ LE R ++EE A+R EE
Sbjct: 824 EERRREEEERRK----QEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEE 879
Query: 374 KKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEAL 433
++R + ++E+Q +++L+RQ+ ++Q A + + +Q Q++ +++ +
Sbjct: 880 EERKRKELEVQ-------RQKELMRQRQQQQEALRRLQQQQQQQQLAQMK-LPSSSTWGQ 931
Query: 434 EDERQARQDEETVRKLQARLLEEESSK--RAELEKWHLEQQQAIQTTEAEKQELEN--QR 489
+ A Q + T+ + + LEEE + R E + E +A+Q + ++Q+ +
Sbjct: 932 QSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGN 991
Query: 490 VLKEQALQEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKS 533
V K +++ +++Q E + Q +Q ++ ++ A N T S
Sbjct: 992 VSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHS 1035
Score = 60.8 bits (146), Expect = 3e-09
Identities = 68/266 (25%), Positives = 125/266 (46%), Gaps = 48/266 (18%)
Query: 341 MKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQ 400
+++LQ ++K +LE R++ E A R EE K+ Q EL+ ++E+++R+Q
Sbjct: 723 LEQLQQLEKAKAAKLEQERREAEMRAKREEEERKR----QEELRR------QQEEILRRQ 772
Query: 401 MEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSK 460
EE+ +K E E+ +R K +EAL +R+ R+ + R +EE+ +
Sbjct: 773 QEEE--RKRREEEELARR---------KQEEALRRQREQEIALRRQREEEERQQQEEALR 821
Query: 461 RAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQ--LELERKQA-LEQY 517
R E E+ E+++ Q KQE E + +E+ +EA +LE+ L +E + A L
Sbjct: 822 RLE-ERRREEEERRKQEELLRKQEEEAAKWAREE--EEAQRRLEENRLRMEEEAARLRHE 878
Query: 518 EEVKKKLEMATNKTKSWKDKVAHHEGLIRLIEPGSKNPHLI-------TNWG-------- 562
EE +K+ E+ + K + + +R ++ + L + WG
Sbjct: 879 EEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTAC 938
Query: 563 --PAAFTEAEL----EEREKNWKEKK 582
A + AE+ EERE+ +E++
Sbjct: 939 QSQATLSLAEIQKLEEERERQLREEQ 964
Score = 50.4 bits (119), Expect = 4e-06
Identities = 49/207 (23%), Positives = 95/207 (45%), Gaps = 32/207 (15%)
Query: 317 KEARQRRKELRKKQ-------LAEQEELERQMKELQAA------------NESKQQELEA 357
+E R++++EL +KQ E+EE +R+++E + E K++ELE
Sbjct: 830 EEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEV 889
Query: 358 VRKKLEEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQ 417
R+K + +E +RLQ Q + Q +L QQ Q + L L
Sbjct: 890 QRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLS--LA 947
Query: 418 RVRELEDMYLKLQEALEDERQARQDE-ETVRKLQARLLEEESSKRAELEKW-HLEQQQAI 475
+++LE+ E ERQ R+++ R+L L +++ ++ +L W ++ +
Sbjct: 948 EIQKLEE---------ERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGT 998
Query: 476 QTTEAEKQELENQRVLKEQALQEAMEQ 502
+ E Q+ E +++ K+Q Q+ +Q
Sbjct: 999 TKSLLEIQQEEARQMQKQQQQQQQHQQ 1025
Score = 47.8 bits (112), Expect = 3e-05
Identities = 42/175 (24%), Positives = 81/175 (46%), Gaps = 18/175 (10%)
Query: 316 HKEARQRRKELRKKQLAEQEELERQMKELQAA---NESKQQELEAVRKKLEEAASRAAEE 372
H+E ++RKEL ++ Q+EL RQ ++ Q A + +QQ+ + + KL +++ +
Sbjct: 877 HEEEERKRKEL---EVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQS 933
Query: 373 EKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEA 432
Q+Q L +LE E+ +Q+ E+ ++ EL + LQ+ ++ + Q+
Sbjct: 934 NTTACQSQATLSLAEIQKLEEER--ERQLREEQRRQQRELMKALQQQQQQQ------QQK 985
Query: 433 LEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELEN 487
L + T + LLE + + +++K +QQQ Q A N
Sbjct: 986 LSGWGNVSKPSGTTKS----LLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHSN 1036
>gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 77.0 bits (188), Expect = 4e-14
Identities = 62/214 (28%), Positives = 116/214 (54%), Gaps = 24/214 (11%)
Query: 312 SPPPHKEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAE 371
+P P E Q+ ++ + +L EQE E +M+ + E K+QE +R++ EE R E
Sbjct: 718 TPGPALEQLQQLEKAKAAKL-EQERREAEMRAKREEEERKRQE--ELRRQQEEILRRQQE 774
Query: 372 EEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQE 431
EE+KR + + EL R ++E+ +R+Q E+++A + E+ Q + E+ +L+E
Sbjct: 775 EERKRREEE-ELARR-----KQEEALRRQREQEIALRRQREEEERQ---QQEEALRRLEE 825
Query: 432 ALEDERQARQDEETVRKLQARLL-----EEESSKRAELEKWHLEQQQAI---QTTEAEKQ 483
+E + R+ EE +RK + EEE+ +R E + +E++ A + E +++
Sbjct: 826 RRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRK 885
Query: 484 ELENQR----VLKEQALQEAMEQLEQLELERKQA 513
ELE QR + + Q QEA+ +L+Q + +++ A
Sbjct: 886 ELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLA 919
Score = 72.0 bits (175), Expect = 1e-12
Identities = 64/202 (31%), Positives = 105/202 (51%), Gaps = 21/202 (10%)
Query: 309 KLGSPPPHKEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASR 368
KL E R +R+E +K+ QEEL RQ +E+ +QQE E R++ EE A R
Sbjct: 736 KLEQERREAEMRAKREEEERKR---QEELRRQQEEILR----RQQEEERKRREEEELARR 788
Query: 369 AAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLK 428
EE +R + Q + +RE+ RQQ EE + + + +R R+ E++ K
Sbjct: 789 KQEEALRRQREQ-----EIALRRQREEEERQQQEEALRRLEERRREEEER-RKQEELLRK 842
Query: 429 LQEALEDERQARQDEETVRKLQA-RLLEEESSKRAELEKWHLEQQQAIQTTEAEKQ-ELE 486
+E E + AR++EE R+L+ RL EE + R H E+++ + E ++Q EL
Sbjct: 843 QEE--EAAKWAREEEEAQRRLEENRLRMEEEAARLR----HEEEERKRKELEVQRQKELM 896
Query: 487 NQRVLKEQALQEAMEQLEQLEL 508
QR +++AL+ +Q +Q +L
Sbjct: 897 RQRQQQQEALRRLQQQQQQQQL 918
Score = 67.4 bits (163), Expect = 3e-11
Identities = 67/244 (27%), Positives = 121/244 (49%), Gaps = 39/244 (15%)
Query: 317 KEARQRRKELRKKQ----LAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEE 372
+E R+R++ELR++Q +QEE ++ +E + A +++ L R++ E A R EE
Sbjct: 752 EEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQ-EIALRRQREE 810
Query: 373 EKKRLQTQV--ELQARFSTELER---EKLIRQQ--------MEEQVAQKSSE-----LEQ 414
E+++ Q + L+ R E ER E+L+R+Q EE+ AQ+ E +E+
Sbjct: 811 EERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEE 870
Query: 415 YLQRVRELED----MYLKLQEALEDERQARQDEETVRKLQARLLEEE--SSKRAELEKW- 467
R+R E+ L++Q E RQ +Q +E +R+LQ + +++ K W
Sbjct: 871 EAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWG 930
Query: 468 ------HLEQQQAIQTTEAEKQELENQRVLKEQ---ALQEAMEQLEQLELERKQALEQYE 518
+ Q + E +K E E +R L+E+ +E M+ L+Q + +++Q L +
Sbjct: 931 QQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWG 990
Query: 519 EVKK 522
V K
Sbjct: 991 NVSK 994
Score = 67.4 bits (163), Expect = 3e-11
Identities = 57/224 (25%), Positives = 114/224 (50%), Gaps = 20/224 (8%)
Query: 318 EARQRRKELRKKQLAEQEELERQMKELQA----ANESKQQELEAVRKKLEEAASRAAEEE 373
E R+R +E R+K QEEL R+ +E A E Q+ LE R ++EE A+R EE
Sbjct: 824 EERRREEEERRK----QEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEE 879
Query: 374 KKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEAL 433
++R + ++E+Q +++L+RQ+ ++Q A + + +Q Q++ +++ +
Sbjct: 880 EERKRKELEVQ-------RQKELMRQRQQQQEALRRLQQQQQQQQLAQMK-LPSSSTWGQ 931
Query: 434 EDERQARQDEETVRKLQARLLEEESSK--RAELEKWHLEQQQAIQTTEAEKQELEN--QR 489
+ A Q + T+ + + LEEE + R E + E +A+Q + ++Q+ +
Sbjct: 932 QSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGN 991
Query: 490 VLKEQALQEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKS 533
V K +++ +++Q E + Q +Q ++ ++ A N T S
Sbjct: 992 VSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHS 1035
Score = 60.8 bits (146), Expect = 3e-09
Identities = 68/266 (25%), Positives = 125/266 (46%), Gaps = 48/266 (18%)
Query: 341 MKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQ 400
+++LQ ++K +LE R++ E A R EE K+ Q EL+ ++E+++R+Q
Sbjct: 723 LEQLQQLEKAKAAKLEQERREAEMRAKREEEERKR----QEELRR------QQEEILRRQ 772
Query: 401 MEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSK 460
EE+ +K E E+ +R K +EAL +R+ R+ + R +EE+ +
Sbjct: 773 QEEE--RKRREEEELARR---------KQEEALRRQREQEIALRRQREEEERQQQEEALR 821
Query: 461 RAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQ--LELERKQA-LEQY 517
R E E+ E+++ Q KQE E + +E+ +EA +LE+ L +E + A L
Sbjct: 822 RLE-ERRREEEERRKQEELLRKQEEEAAKWAREE--EEAQRRLEENRLRMEEEAARLRHE 878
Query: 518 EEVKKKLEMATNKTKSWKDKVAHHEGLIRLIEPGSKNPHLI-------TNWG-------- 562
EE +K+ E+ + K + + +R ++ + L + WG
Sbjct: 879 EEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTAC 938
Query: 563 --PAAFTEAEL----EEREKNWKEKK 582
A + AE+ EERE+ +E++
Sbjct: 939 QSQATLSLAEIQKLEEERERQLREEQ 964
Score = 50.4 bits (119), Expect = 4e-06
Identities = 49/207 (23%), Positives = 95/207 (45%), Gaps = 32/207 (15%)
Query: 317 KEARQRRKELRKKQ-------LAEQEELERQMKELQAA------------NESKQQELEA 357
+E R++++EL +KQ E+EE +R+++E + E K++ELE
Sbjct: 830 EEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEV 889
Query: 358 VRKKLEEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQ 417
R+K + +E +RLQ Q + Q +L QQ Q + L L
Sbjct: 890 QRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLS--LA 947
Query: 418 RVRELEDMYLKLQEALEDERQARQDE-ETVRKLQARLLEEESSKRAELEKW-HLEQQQAI 475
+++LE+ E ERQ R+++ R+L L +++ ++ +L W ++ +
Sbjct: 948 EIQKLEE---------ERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGT 998
Query: 476 QTTEAEKQELENQRVLKEQALQEAMEQ 502
+ E Q+ E +++ K+Q Q+ +Q
Sbjct: 999 TKSLLEIQQEEARQMQKQQQQQQQHQQ 1025
Score = 47.8 bits (112), Expect = 3e-05
Identities = 42/175 (24%), Positives = 81/175 (46%), Gaps = 18/175 (10%)
Query: 316 HKEARQRRKELRKKQLAEQEELERQMKELQAA---NESKQQELEAVRKKLEEAASRAAEE 372
H+E ++RKEL ++ Q+EL RQ ++ Q A + +QQ+ + + KL +++ +
Sbjct: 877 HEEEERKRKEL---EVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQS 933
Query: 373 EKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEA 432
Q+Q L +LE E+ +Q+ E+ ++ EL + LQ+ ++ + Q+
Sbjct: 934 NTTACQSQATLSLAEIQKLEEER--ERQLREEQRRQQRELMKALQQQQQQQ------QQK 985
Query: 433 LEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELEN 487
L + T + LLE + + +++K +QQQ Q A N
Sbjct: 986 LSGWGNVSKPSGTTKS----LLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHSN 1036
>gi|239745153 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 76.3 bits (186), Expect = 7e-14
Identities = 63/293 (21%), Positives = 143/293 (48%), Gaps = 22/293 (7%)
Query: 263 ESLPDKDGK--KCLFLVKCFDKTFEISASDKKKKQEWIQAIHSTIHLLKLGSPPPHKEAR 320
E L +K+ + + L LV+ +++ D K+K E Q + P ++ +
Sbjct: 214 EELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLL------------PQQQLQ 261
Query: 321 QRRKELRKKQLAEQEELERQMKELQAANESKQQELEAV---RKKLEEAASRAAEEEKKRL 377
L K+ + +L+ Q++E + N QQ+ E + +K++E + E+E K
Sbjct: 262 VEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIR 321
Query: 378 QTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDER 437
+ + ++ + E+E+ IR+Q E+++ ++ ++ + +++RE E+ + +E + ++
Sbjct: 322 EQEEKMWRQEEKMHEQEEKIREQ-EDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQD 380
Query: 438 QARQDEETVRKLQARLLEEESSKRAE----LEKWHLEQQQAIQTTEAEKQELENQRVLKE 493
+ Q++E Q + E+ KR E EK EQ + I+ E E E + E
Sbjct: 381 EKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELE 440
Query: 494 QALQEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSWKDKVAHHEGLIR 546
+ +Q+ E+L ++E + ++ E+ +E ++K++ K + ++K E L++
Sbjct: 441 EMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLK 493
Score = 68.9 bits (167), Expect = 1e-11
Identities = 53/233 (22%), Positives = 123/233 (52%), Gaps = 16/233 (6%)
Query: 327 RKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQAR 386
+++++ EQEE R+ ++ E K +E E +K+ E + +E+K + ++Q +
Sbjct: 330 QEEKMHEQEEKIREQEDKMWRQEEKIREQE---EKIREQEEKMWRQEEKIREQDEKIQEQ 386
Query: 387 FSTELEREKLIRQQME---EQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQD- 442
+E+ IR+Q E E++ ++ ++ + +++RE E+ + +E + + + QD
Sbjct: 387 EEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQ 446
Query: 443 EETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQ----ALQE 498
EE +R+++ ++ EEE + + EK Q+Q + E E++ +++LK++ +E
Sbjct: 447 EEKLREVEEKMQEEEEKMQEQEEK---IQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEE 503
Query: 499 AMEQLEQLELERKQALEQYEEVKKKLE--MATNKTKSWKDKVAHHEGLIRLIE 549
M + E+ E+++ +++ EE ++ E M + + W+ + E +RL E
Sbjct: 504 KMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQE 556
Score = 68.6 bits (166), Expect = 2e-11
Identities = 43/217 (19%), Positives = 114/217 (52%), Gaps = 9/217 (4%)
Query: 317 KEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKR 376
+E ++ +E +K ++E++ Q +++Q E ++ E +R++ E+ + +EKK
Sbjct: 356 REQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKM 415
Query: 377 LQTQVELQARFSTELEREKLIR------QQMEEQVAQKSSELEQYLQRVRELEDMYLKLQ 430
+ +++ + +E+ IR Q EE++ + ++++ ++++E E+ + +
Sbjct: 416 REQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQE 475
Query: 431 EALEDERQARQDEETVRKLQARLLE-EESSKRAELEKWHLEQQQAIQTTEAEKQELENQR 489
E ++++ + +E + K + ++ E EE R E + W EQ++ +Q E + Q E +
Sbjct: 476 EKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMW--EQEEKMQEQEEKMQRQEEKM 533
Query: 490 VLKEQALQEAMEQLEQLELERKQALEQYEEVKKKLEM 526
+E L + E++++ E+ ++ E+ ++ +K E+
Sbjct: 534 REQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAEL 570
Score = 67.4 bits (163), Expect = 3e-11
Identities = 47/215 (21%), Positives = 111/215 (51%), Gaps = 8/215 (3%)
Query: 318 EARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRL 377
E ++ +E K ++E++ Q ++++ E ++ E +R++ E+ + E ++
Sbjct: 336 EQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEE 395
Query: 378 QTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDER 437
+ + + + R +EK +R+Q +E++ ++ E+ + +++RELE+M +E L +
Sbjct: 396 KIREQEEKRQEKMWRQEKKMREQ-DEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVE 454
Query: 438 QARQDEETVRKLQARLLEEESSKRAELEK--WH----LEQQQAIQTTEAEKQELENQRVL 491
+ Q+EE + Q ++ + K E E+ W L+Q++ I E + E +
Sbjct: 455 EKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWE 514
Query: 492 KEQALQEAMEQLE-QLELERKQALEQYEEVKKKLE 525
+E+ +QE E+++ Q E R+Q + +++ +K E
Sbjct: 515 QEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQE 549
Score = 62.8 bits (151), Expect = 9e-10
Identities = 52/237 (21%), Positives = 124/237 (52%), Gaps = 20/237 (8%)
Query: 310 LGSPPPHKEARQRRK-ELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASR 368
L K RQ K + +++++ EQE R+ +E E K E E +K+ E +
Sbjct: 291 LNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQE---EKIREQEDK 347
Query: 369 AAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLK 428
+E+K + + +++ + +E+ IR+Q +E++ ++ E+ + +++RE E+ K
Sbjct: 348 MWRQEEKIREQEEKIREQEEKMWRQEEKIREQ-DEKIQEQEEEMWRQEEKIREQEE---K 403
Query: 429 LQEAL-EDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEA------E 481
QE + E++ R+ +E +R+ + + +E R ELE+ +Q++ ++ E E
Sbjct: 404 RQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIR-ELEEMMQDQEEKLREVEEKMQEEEE 462
Query: 482 KQELENQRVLKEQALQEAMEQLEQLELERKQALEQYEEV-KKKLEMATNKTKSWKDK 537
K + + +++ Q +E +++ E+ +++ L+Q E++ +++ +M + K W+ +
Sbjct: 463 KMQEQEEKI---QRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQE 516
Score = 61.2 bits (147), Expect = 2e-09
Identities = 52/223 (23%), Positives = 109/223 (48%), Gaps = 15/223 (6%)
Query: 317 KEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAE---EE 373
+E RQ + ++K++ EQ+E R+ +E E K +ELE + + EE E EE
Sbjct: 401 EEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEE 460
Query: 374 KKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEAL 433
++++Q Q E R +++ ++ + E+ + Q+ EQ + R+ E M+ + ++
Sbjct: 461 EEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQ 520
Query: 434 EDERQARQDEETVRKLQARL------LEEESSKRAELEKWHLEQQQAIQTTEAEKQELEN 487
E E + ++ EE +R+ + RL ++E+ + ELE+ + Q + +E +
Sbjct: 521 EQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAELLGGAGRESGS 580
Query: 488 QR------VLKEQALQEAMEQLEQLELERKQALEQYEEVKKKL 524
QR +L+ + + + L+Q + + L+QY ++L
Sbjct: 581 QRLPTLTPILQVELKSQEAQSLQQQQDHYRGHLQQYVAAYQQL 623
>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 76.3 bits (186), Expect = 7e-14
Identities = 63/293 (21%), Positives = 143/293 (48%), Gaps = 22/293 (7%)
Query: 263 ESLPDKDGK--KCLFLVKCFDKTFEISASDKKKKQEWIQAIHSTIHLLKLGSPPPHKEAR 320
E L +K+ + + L LV+ +++ D K+K E Q + P ++ +
Sbjct: 214 EELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLL------------PQQQLQ 261
Query: 321 QRRKELRKKQLAEQEELERQMKELQAANESKQQELEAV---RKKLEEAASRAAEEEKKRL 377
L K+ + +L+ Q++E + N QQ+ E + +K++E + E+E K
Sbjct: 262 VEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIR 321
Query: 378 QTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDER 437
+ + ++ + E+E+ IR+Q E+++ ++ ++ + +++RE E+ + +E + ++
Sbjct: 322 EQEEKMWRQEEKMHEQEEKIREQ-EDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQD 380
Query: 438 QARQDEETVRKLQARLLEEESSKRAE----LEKWHLEQQQAIQTTEAEKQELENQRVLKE 493
+ Q++E Q + E+ KR E EK EQ + I+ E E E + E
Sbjct: 381 EKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELE 440
Query: 494 QALQEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSWKDKVAHHEGLIR 546
+ +Q+ E+L ++E + ++ E+ +E ++K++ K + ++K E L++
Sbjct: 441 EMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLK 493
Score = 68.9 bits (167), Expect = 1e-11
Identities = 53/233 (22%), Positives = 123/233 (52%), Gaps = 16/233 (6%)
Query: 327 RKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQAR 386
+++++ EQEE R+ ++ E K +E E +K+ E + +E+K + ++Q +
Sbjct: 330 QEEKMHEQEEKIREQEDKMWRQEEKIREQE---EKIREQEEKMWRQEEKIREQDEKIQEQ 386
Query: 387 FSTELEREKLIRQQME---EQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQD- 442
+E+ IR+Q E E++ ++ ++ + +++RE E+ + +E + + + QD
Sbjct: 387 EEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQ 446
Query: 443 EETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQ----ALQE 498
EE +R+++ ++ EEE + + EK Q+Q + E E++ +++LK++ +E
Sbjct: 447 EEKLREVEEKMQEEEEKMQEQEEK---IQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEE 503
Query: 499 AMEQLEQLELERKQALEQYEEVKKKLE--MATNKTKSWKDKVAHHEGLIRLIE 549
M + E+ E+++ +++ EE ++ E M + + W+ + E +RL E
Sbjct: 504 KMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQE 556
Score = 68.6 bits (166), Expect = 2e-11
Identities = 43/217 (19%), Positives = 114/217 (52%), Gaps = 9/217 (4%)
Query: 317 KEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKR 376
+E ++ +E +K ++E++ Q +++Q E ++ E +R++ E+ + +EKK
Sbjct: 356 REQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKM 415
Query: 377 LQTQVELQARFSTELEREKLIR------QQMEEQVAQKSSELEQYLQRVRELEDMYLKLQ 430
+ +++ + +E+ IR Q EE++ + ++++ ++++E E+ + +
Sbjct: 416 REQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQE 475
Query: 431 EALEDERQARQDEETVRKLQARLLE-EESSKRAELEKWHLEQQQAIQTTEAEKQELENQR 489
E ++++ + +E + K + ++ E EE R E + W EQ++ +Q E + Q E +
Sbjct: 476 EKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMW--EQEEKMQEQEEKMQRQEEKM 533
Query: 490 VLKEQALQEAMEQLEQLELERKQALEQYEEVKKKLEM 526
+E L + E++++ E+ ++ E+ ++ +K E+
Sbjct: 534 REQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAEL 570
Score = 67.4 bits (163), Expect = 3e-11
Identities = 47/215 (21%), Positives = 111/215 (51%), Gaps = 8/215 (3%)
Query: 318 EARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRL 377
E ++ +E K ++E++ Q ++++ E ++ E +R++ E+ + E ++
Sbjct: 336 EQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEE 395
Query: 378 QTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDER 437
+ + + + R +EK +R+Q +E++ ++ E+ + +++RELE+M +E L +
Sbjct: 396 KIREQEEKRQEKMWRQEKKMREQ-DEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVE 454
Query: 438 QARQDEETVRKLQARLLEEESSKRAELEK--WH----LEQQQAIQTTEAEKQELENQRVL 491
+ Q+EE + Q ++ + K E E+ W L+Q++ I E + E +
Sbjct: 455 EKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWE 514
Query: 492 KEQALQEAMEQLE-QLELERKQALEQYEEVKKKLE 525
+E+ +QE E+++ Q E R+Q + +++ +K E
Sbjct: 515 QEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQE 549
Score = 62.8 bits (151), Expect = 9e-10
Identities = 52/237 (21%), Positives = 124/237 (52%), Gaps = 20/237 (8%)
Query: 310 LGSPPPHKEARQRRK-ELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASR 368
L K RQ K + +++++ EQE R+ +E E K E E +K+ E +
Sbjct: 291 LNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQE---EKIREQEDK 347
Query: 369 AAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLK 428
+E+K + + +++ + +E+ IR+Q +E++ ++ E+ + +++RE E+ K
Sbjct: 348 MWRQEEKIREQEEKIREQEEKMWRQEEKIREQ-DEKIQEQEEEMWRQEEKIREQEE---K 403
Query: 429 LQEAL-EDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEA------E 481
QE + E++ R+ +E +R+ + + +E R ELE+ +Q++ ++ E E
Sbjct: 404 RQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIR-ELEEMMQDQEEKLREVEEKMQEEEE 462
Query: 482 KQELENQRVLKEQALQEAMEQLEQLELERKQALEQYEEV-KKKLEMATNKTKSWKDK 537
K + + +++ Q +E +++ E+ +++ L+Q E++ +++ +M + K W+ +
Sbjct: 463 KMQEQEEKI---QRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQE 516
Score = 61.2 bits (147), Expect = 2e-09
Identities = 52/223 (23%), Positives = 109/223 (48%), Gaps = 15/223 (6%)
Query: 317 KEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAE---EE 373
+E RQ + ++K++ EQ+E R+ +E E K +ELE + + EE E EE
Sbjct: 401 EEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEE 460
Query: 374 KKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEAL 433
++++Q Q E R +++ ++ + E+ + Q+ EQ + R+ E M+ + ++
Sbjct: 461 EEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQ 520
Query: 434 EDERQARQDEETVRKLQARL------LEEESSKRAELEKWHLEQQQAIQTTEAEKQELEN 487
E E + ++ EE +R+ + RL ++E+ + ELE+ + Q + +E +
Sbjct: 521 EQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAELLGGAGRESGS 580
Query: 488 QR------VLKEQALQEAMEQLEQLELERKQALEQYEEVKKKL 524
QR +L+ + + + L+Q + + L+QY ++L
Sbjct: 581 QRLPTLTPILQVELKSQEAQSLQQQQDHYRGHLQQYVAAYQQL 623
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 74.7 bits (182), Expect = 2e-13
Identities = 69/231 (29%), Positives = 113/231 (48%), Gaps = 17/231 (7%)
Query: 318 EARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRL 377
E ++ K L K + + E + ++E E ++QELE R+KLE S ++ L
Sbjct: 1010 EEEEKSKSLAKLK-NKHEAMITDLEERLRREEKQRQELEKTRRKLE-GDSTDLSDQIAEL 1067
Query: 378 QTQV-ELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDE 436
Q Q+ EL+ + + + E + ++EE+ AQK+ L+ ++RELE +LQE LE E
Sbjct: 1068 QAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALK----KIRELESQISELQEDLESE 1123
Query: 437 RQARQDEETVRKLQARLLEEESSKRAELEKW---HLEQQQAIQTTEAE----KQELENQR 489
R +R E K + L EE + + ELE QQ+ E E K+ LE +
Sbjct: 1124 RASRNKAE---KQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEA 1180
Query: 490 VLKEQALQEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSWKDKVAH 540
E +QE ++ Q E + LEQ + VK LE A ++ + ++A+
Sbjct: 1181 KTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELAN 1231
Score = 67.4 bits (163), Expect = 3e-11
Identities = 71/277 (25%), Positives = 139/277 (50%), Gaps = 32/277 (11%)
Query: 328 KKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQV-----E 382
++ +A++EEL + ++E Q A E++ E+E ++ +L A + +E+ + +T++ E
Sbjct: 845 EEMMAKEEELVK-VREKQLAAENRLTEMETLQSQL--MAEKLQLQEQLQAETELCAEAEE 901
Query: 383 LQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQD 442
L+AR + + + + I +E +V ++ + ++++ +L+E LE+E ARQ
Sbjct: 902 LRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQK 961
Query: 443 --------EETVRKLQAR--LLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLK 492
E ++KL+ +LE+++ K A+ EK LE + A TT ++E +++ + K
Sbjct: 962 LQLEKVTTEAKLKKLEEEQIILEDQNCKLAK-EKKLLEDRIAEFTTNLTEEEEKSKSLAK 1020
Query: 493 EQALQEAM--EQLEQLELERKQALEQYEEVKKKLEMATNKTKSWKDKVAHHEGLIR--LI 548
+ EAM + E+L E KQ ++ E+ ++KLE + D++A + I +
Sbjct: 1021 LKNKHEAMITDLEERLRREEKQR-QELEKTRRKLE---GDSTDLSDQIAELQAQIAELKM 1076
Query: 549 EPGSKNPHLITNWGPAAFTEAELEEREKNWKEKKTTE 585
+ K L AA E E +KN KK E
Sbjct: 1077 QLAKKEEEL-----QAALARVEEEAAQKNMALKKIRE 1108
Score = 66.6 bits (161), Expect = 6e-11
Identities = 65/265 (24%), Positives = 127/265 (47%), Gaps = 21/265 (7%)
Query: 276 LVKCFDKTFEISASDKKKKQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQE 335
LVK +K +++A ++ + E +Q+ L E +ELR + A+++
Sbjct: 854 LVKVREK--QLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQ 911
Query: 336 ELERQMKELQAANESKQ---QELEAVRKK----LEEAASRAAEEEKKRLQTQVELQARFS 388
ELE +L+A E ++ Q L+A +KK ++E + EEE R + Q+E + +
Sbjct: 912 ELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLE---KVT 968
Query: 389 TELEREKLIRQQ--MEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQDEET- 445
TE + +KL +Q +E+Q + + E + R+ E + +E + + + E
Sbjct: 969 TEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAM 1028
Query: 446 VRKLQARLLEEESSK------RAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEA 499
+ L+ RL EE + R +LE + I +A+ EL+ Q KE+ LQ A
Sbjct: 1029 ITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAA 1088
Query: 500 MEQLEQLELERKQALEQYEEVKKKL 524
+ ++E+ ++ AL++ E++ ++
Sbjct: 1089 LARVEEEAAQKNMALKKIRELESQI 1113
Score = 61.2 bits (147), Expect = 2e-09
Identities = 58/244 (23%), Positives = 117/244 (47%), Gaps = 31/244 (12%)
Query: 317 KEARQRRKELRK--KQ--------LAEQEELERQMKELQAANESKQQELEAVRKKLEEAA 366
+EA +++ EL + KQ ++ ++++ + + EL+ + + +Q++E ++ +LEE
Sbjct: 1486 EEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELE 1545
Query: 367 SRAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMY 426
E +L+ +V LQA + ER+ Q +EQ +K +L +++VRE+E
Sbjct: 1546 DELQATEDAKLRLEVNLQA-MKAQFERDL---QGRDEQSEEKKKQL---VRQVREME--- 1595
Query: 427 LKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAE----K 482
LEDER+ R RK L++ + K E + ++ +A+
Sbjct: 1596 ----AELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCM 1651
Query: 483 QELENQRVLKEQALQEAME---QLEQLELERKQALEQYEEVKKKLEMATNKTKSWKDKVA 539
+EL++ R +E+ L +A E +L+ +E E Q E+ ++ A + D++A
Sbjct: 1652 RELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIA 1711
Query: 540 HHEG 543
+ G
Sbjct: 1712 NSSG 1715
Score = 61.2 bits (147), Expect = 2e-09
Identities = 70/270 (25%), Positives = 121/270 (44%), Gaps = 37/270 (13%)
Query: 289 SDKKKKQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRKKQLA--------EQEELERQ 340
S++KKKQ Q L A +++ E+ K L ++E +Q
Sbjct: 1580 SEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQ 1639
Query: 341 MKELQAANESKQQELEAVRKKLEEAASRAAEEEKK-------RLQTQVELQA--RFSTEL 391
+++LQA + +EL+ R EE ++A E EKK +Q Q EL A R +
Sbjct: 1640 LRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQA 1699
Query: 392 EREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQA 451
++E R ++ +++A S + L+ R LE +L+E LE+E Q + R +A
Sbjct: 1700 QQE---RDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEE-QGNTELINDRLKKA 1755
Query: 452 RLLEEESSKRAELEKWHLEQ-QQAIQTTEAEKQEL-----ENQRVLK----------EQA 495
L ++ + LE+ H ++ + A Q E + +EL E + +K E
Sbjct: 1756 NLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAK 1815
Query: 496 LQEAMEQLEQLELERKQALEQYEEVKKKLE 525
+ + EQL+ ER+ A +Q +KKL+
Sbjct: 1816 IAQLEEQLDNETKERQAACKQVRRTEKKLK 1845
Score = 60.1 bits (144), Expect = 6e-09
Identities = 93/377 (24%), Positives = 161/377 (42%), Gaps = 64/377 (16%)
Query: 193 RQTVSMAINEVFNELILDVLKQGYMMKKG---HRRKNWTERWFVLKPNIIS-YYVSEDLK 248
+QT+ E+ NE+ VL QG KG H+RK + L+ V +L
Sbjct: 1219 KQTLENERGELANEV--KVLLQG----KGDSEHKRKKVEAQLQELQVKFNEGERVRTELA 1272
Query: 249 DKKGDILLDENCCVESLPDKDGKKCLFLVKCFDKTFEISASDKKKKQEWIQAIHSTIHLL 308
DK + ++ + L D K K F S + QE +Q +
Sbjct: 1273 DKVTKLQVELDNVTGLLSQSDSKSSKLT-----KDFSALESQLQDTQELLQEENRQ---- 1323
Query: 309 KLGSPPPHKEARQRRKELRKKQLAEQEE----LERQMKELQAANESKQQELEAVRKKLEE 364
KL K+ + R+ QL E+EE LE+Q+ L A ++ ++KK+E+
Sbjct: 1324 KLSLSTKLKQVEDEKNSFRE-QLEEEEEAKHNLEKQIATLHA-------QVADMKKKMED 1375
Query: 365 AAS--RAAEEEKKRLQTQVE-LQARFSTEL---EREKLIRQQMEEQVAQKSSELEQYLQR 418
+ AEE K++LQ +E L R ++ ++ + + ++++++ +L+ Q
Sbjct: 1376 SVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQS 1435
Query: 419 VRELEDMYLKLQEALEDER---------------QARQDEETVRKLQARLLEEESSKRAE 463
LE K + L +E+ +AR+ E L AR LEE ++AE
Sbjct: 1436 ACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSL-ARALEEAMEQKAE 1494
Query: 464 LEKWHLEQQQAIQTTEAEK-------QELENQRVLKEQALQEAMEQLEQLELERKQALEQ 516
LE+ + + + ++ + K ELE + EQ ++E QLE+LE E L+
Sbjct: 1495 LERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDE----LQA 1550
Query: 517 YEEVKKKLEMATNKTKS 533
E+ K +LE+ K+
Sbjct: 1551 TEDAKLRLEVNLQAMKA 1567
Score = 59.7 bits (143), Expect = 7e-09
Identities = 70/278 (25%), Positives = 125/278 (44%), Gaps = 38/278 (13%)
Query: 293 KKQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRK-----KQLAE-QEELERQMKELQA 346
KK+E +QA + + +EA Q+ L+K Q++E QE+LE +
Sbjct: 1080 KKEEELQAALARVE----------EEAAQKNMALKKIRELESQISELQEDLESERASRNK 1129
Query: 347 ANESKQ---QELEAVRKKLEEAASRAAEEEKKRLQTQVE---LQARFSTELEREKLIRQQ 400
A + K+ +ELEA++ +LE+ A +++ R + + E L+ E + + Q+
Sbjct: 1130 AEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQE 1189
Query: 401 MEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDER-----------QARQDEETVRKL 449
M ++ +Q EL + L++ + ++ K ++ LE+ER Q + D E RK
Sbjct: 1190 MRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKK 1249
Query: 450 QARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQE---LENQRVLKEQALQEAMEQLEQL 506
L+E K E E+ E + + E L +Q K L + LE
Sbjct: 1250 VEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALES- 1308
Query: 507 ELERKQALEQYEEVKKKLEMATNKTKSWKDKVAHHEGL 544
+L+ Q L Q EE ++KL ++T + +K + E L
Sbjct: 1309 QLQDTQELLQ-EENRQKLSLSTKLKQVEDEKNSFREQL 1345
Score = 57.4 bits (137), Expect = 4e-08
Identities = 60/255 (23%), Positives = 123/255 (48%), Gaps = 30/255 (11%)
Query: 317 KEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKR 376
K+ +Q +EL ++QL E+E ++++ + E+K ++LE + LE+ + A+E+K
Sbjct: 939 KKMQQNIQEL-EEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLL 997
Query: 377 LQTQVELQARFSTELEREKLIRQ----------QMEEQVAQKSSELEQYLQRVRELE--- 423
E + E E+ K + + +EE++ ++ + ++ + R+LE
Sbjct: 998 EDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDS 1057
Query: 424 ----DMYLKLQ-EALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTT 478
D +LQ + E + Q + EE ++ AR+ EE + K L+K + Q +
Sbjct: 1058 TDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQ 1117
Query: 479 EAEKQELENQRVLKEQALQEAM---EQLEQLELERKQALEQ---YEEVKKKLEMATN-KT 531
E +LE++R + +A ++ E+LE L+ E + L+ +E++ K E N
Sbjct: 1118 E----DLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILK 1173
Query: 532 KSWKDKVAHHEGLIR 546
K+ +++ HE I+
Sbjct: 1174 KTLEEEAKTHEAQIQ 1188
Score = 50.4 bits (119), Expect = 4e-06
Identities = 61/271 (22%), Positives = 123/271 (45%), Gaps = 37/271 (13%)
Query: 288 ASDKKKKQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRKK----------QLAEQEEL 337
A + +KK + ++A + + ++A+Q R EL + L E+ L
Sbjct: 1668 AKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRL 1727
Query: 338 ERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTELE--REK 395
E ++ +L+ E +Q E + +L++A + + + T + L+ + + E R++
Sbjct: 1728 EARIAQLEEELEEEQGNTELINDRLKKANLQIDQ-----INTDLNLERSHAQKNENARQQ 1782
Query: 396 LIRQQMEEQVAQKSSE---LEQYLQRVRELEDMYLKLQEALEDERQARQD-----EETVR 447
L RQ E +V + E +Y + LE +L+E L++E + RQ T +
Sbjct: 1783 LERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEK 1842
Query: 448 KLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLE 507
KL+ LL+ + +R E++ + QA + + KQ LK Q L+EA E+ ++
Sbjct: 1843 KLKDVLLQVDDERR-NAEQY---KDQADKASTRLKQ-------LKRQ-LEEAEEEAQRAN 1890
Query: 508 LERKQALEQYEEVKKKLEMATNKTKSWKDKV 538
R++ + E+ + + + S K+K+
Sbjct: 1891 ASRRKLQRELEDATETADAMNREVSSLKNKL 1921
Score = 43.9 bits (102), Expect = 4e-04
Identities = 53/258 (20%), Positives = 105/258 (40%), Gaps = 33/258 (12%)
Query: 285 EISASDKKKKQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQEELERQMKEL 344
E++A+++ K+Q + + +RR E R QL +EELE +
Sbjct: 1688 ELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQL--EEELEEEQGNT 1745
Query: 345 QAANESKQQ---ELEAVRKKLEEAASRAAEEEKKRLQTQ-------VELQARFSTELERE 394
+ N+ ++ +++ + L S A + E R Q + V+LQ T +
Sbjct: 1746 ELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKY 1805
Query: 395 KLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLL 454
K +E ++AQ +L+ E E + +Q T +KL+ LL
Sbjct: 1806 KASITALEAKIAQLEEQLD----------------NETKERQAACKQVRRTEKKLKDVLL 1849
Query: 455 EEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQAL 514
+ + +R E++ + +A + K++LE E+ Q A +L+ E + A
Sbjct: 1850 QVDDERR-NAEQYKDQADKASTRLKQLKRQLEE----AEEEAQRANASRRKLQRELEDAT 1904
Query: 515 EQYEEVKKKLEMATNKTK 532
E + + +++ NK +
Sbjct: 1905 ETADAMNREVSSLKNKLR 1922
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 73.2 bits (178), Expect = 6e-13
Identities = 60/234 (25%), Positives = 122/234 (52%), Gaps = 19/234 (8%)
Query: 318 EARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRL 377
E Q R++ ++ A + + E ++ E+Q +S +ELE + K E A + EE ++R
Sbjct: 1468 ELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEE-RQRF 1526
Query: 378 QTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEAL--ED 435
Q E + + + ++E+ ++ +++ +QV + S +L Q +++ LK +A E
Sbjct: 1527 Q---EERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQ-ASKVQQQKLKAVQAQGGES 1582
Query: 436 ERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQA 495
+++A++ + + +LQA+L ++E + E + L+ ++A +A+KQ+ Q
Sbjct: 1583 QQEAQRLQAQLNELQAQLSQKEQAA----EHYKLQMEKAKTHYDAKKQQ--------NQE 1630
Query: 496 LQEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSWKDKVAHHEGLIRLIE 549
LQE + LEQL+ E K+ + E + +L+ A KTK + H +R +E
Sbjct: 1631 LQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLE 1684
Score = 60.1 bits (144), Expect = 6e-09
Identities = 58/268 (21%), Positives = 130/268 (48%), Gaps = 19/268 (7%)
Query: 290 DKKKKQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRKKQ--LAEQEELERQMKELQAA 347
+K + ++ + + + + + + +LR +Q E+E + ++ +LQ
Sbjct: 644 EKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQ 703
Query: 348 NESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQ 407
++ ++ L+ + LEE RAA+ +++ + EL+A + +E+ K R+++EE+ A
Sbjct: 704 LQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAG 763
Query: 408 KSSELEQYLQRV-----RELEDMYLKLQEALEDERQARQD-EETVRKLQARLLEEESSKR 461
+ LE LQ++ E E + +L EA+ + A + E+ V+++ A E S++
Sbjct: 764 RKG-LEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQ 822
Query: 462 AELEKWHLEQQQAI---QTTEAEKQELENQR-----VLKEQALQEAMEQLEQLELERK-- 511
E + + Q+Q + + E +QEL+ + + LQ + +Q E EL
Sbjct: 823 EEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLA 882
Query: 512 QALEQYEEVKKKLEMATNKTKSWKDKVA 539
+AL+Q +E + + + + + ++K+A
Sbjct: 883 RALQQVQEKEVRAQKLADDLSTLQEKMA 910
Score = 59.7 bits (143), Expect = 7e-09
Identities = 55/206 (26%), Positives = 99/206 (48%), Gaps = 22/206 (10%)
Query: 328 KKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARF 387
+KQ + + LER ++ +A+ + LE ++ +LEE A + Q EL A F
Sbjct: 1137 QKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQREL-AAF 1195
Query: 388 STELEREKLIRQQMEEQVAQKSSELEQYLQRVREL-EDMYLKLQEALEDERQARQ----- 441
T+++ + + QVA+ E E+ + L E++ + ++ LE E ++++
Sbjct: 1196 RTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLV 1255
Query: 442 --DEETVRKLQ--ARLLEEE----SSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKE 493
+ E +KL+ RLL+ E S++ AE E+ Q++ ++E E QRV E
Sbjct: 1256 MAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSL------REEAEKQRVASE 1309
Query: 494 QALQEAMEQLEQLELERKQALEQYEE 519
QE Q E+ E E Q L+ ++E
Sbjct: 1310 NLRQELTSQAERAE-ELGQELKAWQE 1334
Score = 55.1 bits (131), Expect = 2e-07
Identities = 61/273 (22%), Positives = 114/273 (41%), Gaps = 26/273 (9%)
Query: 326 LRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASR---------AAEEEKKR 376
L Q+ E EEL + +K+L+ K++E + EAA R A E +
Sbjct: 1072 LEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSK 1131
Query: 377 LQTQVELQARFSTELER----EKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEA 432
L+ Q + Q + LER E+ R + + + +LE+ Q + + Q
Sbjct: 1132 LEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRE 1191
Query: 433 LEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLK 492
L R QD E+E + + E++ ++ ++ E+ + N++VL+
Sbjct: 1192 LAAFRTKVQDHSKA--------EDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLE 1243
Query: 493 EQALQEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSWKDKVAHHEGLIRLIEPGS 552
++ + +++L E E+ Q LE+ + + E A+N ++ + A E + L E
Sbjct: 1244 KEGESKELKRLVMAESEKSQKLEERLRL-LQAETASNSARAAERSSALREEVQSLREEAE 1302
Query: 553 KNPHLITNWGPAAFTEA----ELEEREKNWKEK 581
K N ++A EL + K W+EK
Sbjct: 1303 KQRVASENLRQELTSQAERAEELGQELKAWQEK 1335
Score = 54.3 bits (129), Expect = 3e-07
Identities = 81/319 (25%), Positives = 133/319 (41%), Gaps = 78/319 (24%)
Query: 294 KQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQEELERQMKELQAANESKQQ 353
+ E Q + + LL+ + A +R LR++ + +EE E+Q + A+E+ +Q
Sbjct: 1258 ESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQ----RVASENLRQ 1313
Query: 354 ELEAVRKKLEEAASRAAEEEKKRLQTQVEL----------QARFSTELEREKLIRQQMEE 403
EL + ++ EE ++K Q + L QA S L + L +Q E
Sbjct: 1314 ELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAE 1373
Query: 404 QVAQKS---SELEQ-----------YLQRVRELEDMYLKLQEALEDERQARQ-------- 441
Q A + ELEQ L+ REL ++ Q+ E ER A+Q
Sbjct: 1374 QAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASY 1433
Query: 442 -DEETVRKLQARLLEEES---SKRAELEKWHLE-----------QQQAIQTTEAEKQELE 486
++ ++ K LL EE+ +RA L + LE Q+ A +AE + E
Sbjct: 1434 AEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAE 1493
Query: 487 NQR----------------------VLKE-QALQEAME----QLEQLELERKQALEQYEE 519
QR VL+E Q QE + Q+EQLE+ +++ +Q EE
Sbjct: 1494 VQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEE 1553
Query: 520 VKKKLEMATNKTKSWKDKV 538
+ KKL + +K + K+
Sbjct: 1554 LSKKLADSDQASKVQQQKL 1572
Score = 53.9 bits (128), Expect = 4e-07
Identities = 45/202 (22%), Positives = 94/202 (46%), Gaps = 23/202 (11%)
Query: 333 EQEELERQMKELQAANES---KQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFST 389
E+ +++R++ +L N K +E + ++L++A + EE K Q +E QA+
Sbjct: 305 EKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEK 364
Query: 390 ELE---REKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQDEETV 446
EL ++K ++ E + K S+LE++L + L+D + E
Sbjct: 365 ELSAALQDKKCLEEKNEILQGKLSQLEEHLSQ--------------LQDNPPQEKGEVLG 410
Query: 447 RKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQL 506
LQ L++E+ A L + + Q ++ E E+ + E + + + +E +QL L
Sbjct: 411 DVLQLETLKQEA---ATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSL 467
Query: 507 ELERKQALEQYEEVKKKLEMAT 528
+ + ++ + K++LE A+
Sbjct: 468 ITDLQSSISNLSQAKEELEQAS 489
Score = 52.8 bits (125), Expect = 9e-07
Identities = 65/270 (24%), Positives = 118/270 (43%), Gaps = 48/270 (17%)
Query: 317 KEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEE------AASRAA 370
+E +Q+ L + L + +EL+ A+++ L A L A +
Sbjct: 458 EEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQ 517
Query: 371 EEEKKRLQTQV-ELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVREL------- 422
++E L+ Q E QA+ + L++++ Q + QV Q SS L+Q Q+++E+
Sbjct: 518 DQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEAT 577
Query: 423 -EDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHL----EQQQAIQT 477
+D +L A E ER+A E Q LE+E + + E+ + L E + + QT
Sbjct: 578 RQDHAQQLATAAE-EREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQT 636
Query: 478 --TEAEKQELENQRVLKE---------QALQEAMEQLEQLEL-----------------E 509
T+A++++ E R ++E Q EA Q+ +LEL E
Sbjct: 637 SVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQE 696
Query: 510 RKQALEQYEEVKKKLEMATNKTKSWKDKVA 539
+ Q EQ + +K+ L++ + K + A
Sbjct: 697 KDQLQEQLQALKESLKVTKGSLEEEKRRAA 726
Score = 52.0 bits (123), Expect = 2e-06
Identities = 73/276 (26%), Positives = 123/276 (44%), Gaps = 37/276 (13%)
Query: 317 KEARQRRKELRKK----QLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEE 372
++ARQ +E ++K + + ++ RQ EL + + + L+ V++K E A + A++
Sbjct: 843 EKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEK-EVRAQKLADD 901
Query: 373 EKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEA 432
L T E A S E+ R + + ++ EQ S EL + R + + +L
Sbjct: 902 ----LSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWL----- 952
Query: 433 LEDERQARQDEETVRKLQARLLE-EESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVL 491
+E+Q RQ T LQA E E+ E + L + Q Q E +QE E R+
Sbjct: 953 --EEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLT 1010
Query: 492 KEQALQEAMEQLE-----QLELERKQALEQYEEVKKKLEMATNKTKSWKDKVAHHEGLIR 546
+E+ +A LE +LE+ + AL + +++E AT ++ +AH
Sbjct: 1011 QERGRAQADLALEKAARAELEMRLQNALNE-----QRVEFAT-----LQEALAH-----A 1055
Query: 547 LIEPGSKNPHLITNWGPAAFTEAELEEREKNWKEKK 582
L E K+ L G A ELEE + K+ K
Sbjct: 1056 LTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLK 1091
Score = 48.9 bits (115), Expect = 1e-05
Identities = 70/284 (24%), Positives = 128/284 (45%), Gaps = 34/284 (11%)
Query: 281 DKTFEISASDKK---KKQEWIQAIHSTI--HLLKLGSPPPHKEARQRRKELRKKQLAEQE 335
+K + DKK +K E +Q S + HL +L PP ++ L+ + L ++
Sbjct: 363 EKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEA 422
Query: 336 E-LERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQV-ELQARFSTELER 393
L +LQA E + E KL A EEEK++L + + +LQ+ S +
Sbjct: 423 ATLAANNTQLQARVEMLETERGQQEAKL-LAERGHFEEEKQQLSSLITDLQSSISNLSQA 481
Query: 394 EKLIRQ-------QMEEQVAQKSSEL-------EQYLQRV----RELEDMYLKLQEALED 435
++ + Q ++ QVA +SEL +Q Q + ++ ++ +L + L+
Sbjct: 482 KEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQ 541
Query: 436 ERQARQD-EETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQ 494
+ QA Q V +L + L ++E + EK Q+A T + Q+L +E
Sbjct: 542 QEQASQGLRHQVEQLSSSLKQKEQQLKEVAEK-----QEA--TRQDHAQQLATAAEEREA 594
Query: 495 ALQEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSWKDKV 538
+L+E L+QLE K+ + E ++++L++A S + V
Sbjct: 595 SLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSV 638
Score = 47.4 bits (111), Expect = 4e-05
Identities = 63/237 (26%), Positives = 108/237 (45%), Gaps = 28/237 (11%)
Query: 318 EARQRRKELRKK--QLAE-QEELERQ--MKELQAANESKQQELEAVRKKLEEAASRAAEE 372
E + RK L +K Q+A Q+ ++R + E QAA+ + +ELE +R K E R E
Sbjct: 236 ELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMRLHET 295
Query: 373 EKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEA 432
K+ +L+ EK QM+ ++ Q S E ++RE +LQ+A
Sbjct: 296 LKQ------------CQDLKTEK---SQMDRKINQLSEENGDLSFKLREFASHLQQLQDA 340
Query: 433 LED--ERQARQDEETVRKLQARLLEEESS----KRAELEKWHLEQQQAIQTTEAEKQELE 486
L + E ++ +E + K QA+L +E S+ K+ EK + Q + Q E Q +
Sbjct: 341 LNELTEEHSKATQEWLEK-QAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQD 399
Query: 487 NQRVLKEQALQEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSWKDKVAHHEG 543
N K + L + + QLE L+ E +++ ++EM + + K+ G
Sbjct: 400 NPPQEKGEVLGDVL-QLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERG 455
Score = 35.0 bits (79), Expect = 0.19
Identities = 24/108 (22%), Positives = 54/108 (50%), Gaps = 2/108 (1%)
Query: 308 LKLGSPPPHKEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEA-- 365
L++ H +A++++ + ++QL E+L+++ KEL+A E EL+ K +EA
Sbjct: 1612 LQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQ 1671
Query: 366 ASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELE 413
R + + L+ QV + +L + ++ ++ + Q +L+
Sbjct: 1672 TCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQAKPQLD 1719
>gi|239745299 PREDICTED: hypothetical protein [Homo sapiens]
Length = 523
Score = 72.8 bits (177), Expect = 8e-13
Identities = 63/221 (28%), Positives = 116/221 (52%), Gaps = 23/221 (10%)
Query: 320 RQRRKELRKKQ--LAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRL 377
R++ + LR+++ L EQEE R+ +E E + +E E ++L E R E+E++
Sbjct: 195 RRQEERLREQEERLREQEERLREQEERLCEQEERLREQE---ERLREQEERLCEQEERLR 251
Query: 378 QTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEAL-EDE 436
+ + L + E+E+ +R+Q EE++ ++ L + +R+RE E+ + +E L E E
Sbjct: 252 EHEERLCEQEERLCEQEERLREQ-EERLHEQEERLCEQEERLREQEERLCEQEERLREQE 310
Query: 437 RQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVL-KEQA 495
+ + EE +R+ + RL E+E E +E + E E+++ E +R+L +E+
Sbjct: 311 ERLCEQEERLREQEERLCEQEKLPGQERLLEEVE-----KLLEQERRQEEQERLLERERL 365
Query: 496 LQEAMEQLEQLEL----------ERKQALEQYEEVKKKLEM 526
L+E E LEQ L E Q LE+ E+++ LE+
Sbjct: 366 LEEVEELLEQERLRQQDERLWQQETLQELERLRELERMLEL 406
Score = 72.0 bits (175), Expect = 1e-12
Identities = 70/290 (24%), Positives = 142/290 (48%), Gaps = 34/290 (11%)
Query: 287 SASDKKKKQEWIQAIHSTIHLLK------LGSPPPHKEARQRRKELRKKQLAEQEELERQ 340
S +KK + +Q + ++ LK L PP ++ + + L ++ELE
Sbjct: 119 SKEEKKHEIHLVQKLGRSLFKLKNQTAEPLAPEPPAGPSKVEQLQDETNHL--RKELESV 176
Query: 341 MKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQ 400
++LQA E+ Q L + ++ EE R E+E++ + + L+ + E+E+ +R+Q
Sbjct: 177 GRQLQAEVENNQM-LSLLNRRQEE---RLREQEERLREQEERLREQEERLCEQEERLREQ 232
Query: 401 MEEQVAQKSSELEQYLQRVRELEDMYLKLQEAL-EDERQARQDEETVRKLQARLLEEESS 459
EE++ ++ L + +R+RE E+ + +E L E E + R+ EE + + + RL E+E
Sbjct: 233 -EERLREQEERLCEQEERLREHEERLCEQEERLCEQEERLREQEERLHEQEERLCEQEER 291
Query: 460 KR------AELEKWHLEQQQAI-----QTTEAEKQELENQRVLKEQALQEAMEQLEQLE- 507
R E E+ EQ++ + + E E++ E +++ ++ L E +E+L + E
Sbjct: 292 LREQEERLCEQEERLREQEERLCEQEERLREQEERLCEQEKLPGQERLLEEVEKLLEQER 351
Query: 508 --------LERKQALEQYEEVKKKLEMATNKTKSWKDKVAHHEGLIRLIE 549
LER++ LE+ EE+ ++ + + W+ + +R +E
Sbjct: 352 RQEEQERLLERERLLEEVEELLEQERLRQQDERLWQQETLQELERLRELE 401
Score = 55.1 bits (131), Expect = 2e-07
Identities = 59/249 (23%), Positives = 111/249 (44%), Gaps = 52/249 (20%)
Query: 335 EELERQMKELQAA----------------------NESKQQELEAVRK---KLEEAASRA 369
E+LE Q +EL A E K+ E+ V+K L + ++
Sbjct: 85 EDLESQYQELAVALDSSSAIISQLTENINSLVRTSKEEKKHEIHLVQKLGRSLFKLKNQT 144
Query: 370 AE-----------------EEKKRLQTQVELQAR-FSTELEREK---LIRQQMEEQVAQK 408
AE +E L+ ++E R E+E + L+ ++ EE++ ++
Sbjct: 145 AEPLAPEPPAGPSKVEQLQDETNHLRKELESVGRQLQAEVENNQMLSLLNRRQEERLREQ 204
Query: 409 SSELEQYLQRVRELEDMYLKLQEAL-EDERQARQDEETVRKLQARLLEEESSKRAELEKW 467
L + +R+RE E+ + +E L E E + R+ EE + + + RL E E + E E+
Sbjct: 205 EERLREQEERLREQEERLCEQEERLREQEERLREQEERLCEQEERLREHE-ERLCEQEER 263
Query: 468 HLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQL----EQLELERKQALEQYEEVKKK 523
EQ++ ++ E E E + +E+ L+E E+L E+L + ++ EQ E ++++
Sbjct: 264 LCEQEERLREQEERLHEQEERLCEQEERLREQEERLCEQEERLREQEERLCEQEERLREQ 323
Query: 524 LEMATNKTK 532
E + K
Sbjct: 324 EERLCEQEK 332
Score = 48.1 bits (113), Expect = 2e-05
Identities = 47/157 (29%), Positives = 83/157 (52%), Gaps = 19/157 (12%)
Query: 318 EARQRRKELRKKQLAEQEELERQMKELQAANES---KQQELEAVRKKLEEAASRAAEEEK 374
E +R +E ++++L EQEE R+ +E E +++ LE V K LE+ +EE+
Sbjct: 301 EQEERLRE-QEERLCEQEERLREQEERLCEQEKLPGQERLLEEVEKLLEQ---ERRQEEQ 356
Query: 375 KRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALE 434
+RL + L LE+E+L +Q +E++ Q+ E Q L+R+RELE M EAL
Sbjct: 357 ERLLERERLLEEVEELLEQERL--RQQDERLWQQ--ETLQELERLRELERMLELGWEALY 412
Query: 435 DER--------QARQDEETVRKLQARLLEEESSKRAE 463
++R + + ++ +L+ ++ E + S AE
Sbjct: 413 EQRAEPRSGFEELNNENKSTLQLEQQVKELKKSGGAE 449
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.129 0.365
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,134,826
Number of Sequences: 37866
Number of extensions: 1067741
Number of successful extensions: 29526
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 861
Number of HSP's successfully gapped in prelim test: 1381
Number of HSP's that attempted gapping in prelim test: 6772
Number of HSP's gapped (non-prelim): 10114
length of query: 585
length of database: 18,247,518
effective HSP length: 108
effective length of query: 477
effective length of database: 14,157,990
effective search space: 6753361230
effective search space used: 6753361230
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.