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Search of human proteins with 93004081
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|93004081 polo-like kinase 2 [Homo sapiens]
(685 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|93004081 polo-like kinase 2 [Homo sapiens] 1411 0.0
gi|41872374 polo-like kinase 3 [Homo sapiens] 625 e-179
gi|21359873 polo-like kinase 1 [Homo sapiens] 447 e-125
gi|121114283 polo-like kinase 4 [Homo sapiens] 219 5e-57
gi|7662170 AMPK-related protein kinase 5 [Homo sapiens] 173 5e-43
gi|38327572 serine/threonine protein kinase 6 [Homo sapiens] 166 9e-41
gi|38327570 serine/threonine protein kinase 6 [Homo sapiens] 166 9e-41
gi|38327568 serine/threonine protein kinase 6 [Homo sapiens] 166 9e-41
gi|38327566 serine/threonine protein kinase 6 [Homo sapiens] 166 9e-41
gi|38327564 serine/threonine protein kinase 6 [Homo sapiens] 166 9e-41
gi|38327562 serine/threonine protein kinase 6 [Homo sapiens] 166 9e-41
gi|83776600 aurora kinase B [Homo sapiens] 164 3e-40
gi|62865641 aurora kinase C isoform 2 [Homo sapiens] 156 5e-38
gi|62865639 aurora kinase C isoform 1 [Homo sapiens] 156 5e-38
gi|62865643 aurora kinase C isoform 3 [Homo sapiens] 154 2e-37
gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo ... 154 3e-37
gi|193083129 MAP/microtubule affinity-regulating kinase 3 isofor... 153 4e-37
gi|193083127 MAP/microtubule affinity-regulating kinase 3 isofor... 152 8e-37
gi|193083125 MAP/microtubule affinity-regulating kinase 3 isofor... 152 8e-37
gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform... 152 8e-37
gi|254028240 MAP/microtubule affinity-regulating kinase 2 isofor... 151 2e-36
gi|254028237 MAP/microtubule affinity-regulating kinase 2 isofor... 151 2e-36
gi|254028234 MAP/microtubule affinity-regulating kinase 2 isofor... 151 2e-36
gi|254028232 MAP/microtubule affinity-regulating kinase 2 isofor... 151 2e-36
gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform... 151 2e-36
gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens] 149 6e-36
gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 148 1e-35
gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho... 148 2e-35
gi|24308326 BR serine/threonine kinase 1 [Homo sapiens] 148 2e-35
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 147 3e-35
>gi|93004081 polo-like kinase 2 [Homo sapiens]
Length = 685
Score = 1411 bits (3653), Expect = 0.0
Identities = 685/685 (100%), Positives = 685/685 (100%)
Query: 1 MELLRTITYQPAASTKMCEQALGKGCGADSKKKRPPQPPEESQPPQSQAQVPPAAPHHHH 60
MELLRTITYQPAASTKMCEQALGKGCGADSKKKRPPQPPEESQPPQSQAQVPPAAPHHHH
Sbjct: 1 MELLRTITYQPAASTKMCEQALGKGCGADSKKKRPPQPPEESQPPQSQAQVPPAAPHHHH 60
Query: 61 HHSHSGPEISRIIVDPTTGKRYCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAK 120
HHSHSGPEISRIIVDPTTGKRYCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAK
Sbjct: 61 HHSHSGPEISRIIVDPTTGKRYCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAK 120
Query: 121 PHQREKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEP 180
PHQREKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEP
Sbjct: 121 PHQREKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEP 180
Query: 181 EVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTI 240
EVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTI
Sbjct: 181 EVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTI 240
Query: 241 CGTPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMP 300
CGTPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMP
Sbjct: 241 CGTPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMP 300
Query: 301 SSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFLQGFTPDRLSSSCCHTVPDFHLSSPA 360
SSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFLQGFTPDRLSSSCCHTVPDFHLSSPA
Sbjct: 301 SSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFLQGFTPDRLSSSCCHTVPDFHLSSPA 360
Query: 361 KNFFKKAAAALFGGKKDKARYIDTHNRVSKEDEDIYKLRHDLKKTSITQQPSKHRTDEEL 420
KNFFKKAAAALFGGKKDKARYIDTHNRVSKEDEDIYKLRHDLKKTSITQQPSKHRTDEEL
Sbjct: 361 KNFFKKAAAALFGGKKDKARYIDTHNRVSKEDEDIYKLRHDLKKTSITQQPSKHRTDEEL 420
Query: 421 QPPTTTVARSGTPAVENKQQIGDAIRMIVRGTLGSCSSSSECLEDSTMGSVADTVARVLR 480
QPPTTTVARSGTPAVENKQQIGDAIRMIVRGTLGSCSSSSECLEDSTMGSVADTVARVLR
Sbjct: 421 QPPTTTVARSGTPAVENKQQIGDAIRMIVRGTLGSCSSSSECLEDSTMGSVADTVARVLR 480
Query: 481 GCLENMPEADCIPKEQLSTSFQWVTKWVDYSNKYGFGYQLSDHTVGVLFNNGAHMSLLPD 540
GCLENMPEADCIPKEQLSTSFQWVTKWVDYSNKYGFGYQLSDHTVGVLFNNGAHMSLLPD
Sbjct: 481 GCLENMPEADCIPKEQLSTSFQWVTKWVDYSNKYGFGYQLSDHTVGVLFNNGAHMSLLPD 540
Query: 541 KKTVHYYAELGQCSVFPATDAPEQFISQVTVLKYFSHYMEENLMDGGDLPSVTDIRRPRL 600
KKTVHYYAELGQCSVFPATDAPEQFISQVTVLKYFSHYMEENLMDGGDLPSVTDIRRPRL
Sbjct: 541 KKTVHYYAELGQCSVFPATDAPEQFISQVTVLKYFSHYMEENLMDGGDLPSVTDIRRPRL 600
Query: 601 YLLQWLKSDKALMMLFNDGTFQVNFYHDHTKIIICSQNEEYLLTYINEDRISTTFRLTTL 660
YLLQWLKSDKALMMLFNDGTFQVNFYHDHTKIIICSQNEEYLLTYINEDRISTTFRLTTL
Sbjct: 601 YLLQWLKSDKALMMLFNDGTFQVNFYHDHTKIIICSQNEEYLLTYINEDRISTTFRLTTL 660
Query: 661 LMSGCSSELKNRMEYALNMLLQRCN 685
LMSGCSSELKNRMEYALNMLLQRCN
Sbjct: 661 LMSGCSSELKNRMEYALNMLLQRCN 685
>gi|41872374 polo-like kinase 3 [Homo sapiens]
Length = 646
Score = 625 bits (1611), Expect = e-179
Identities = 327/650 (50%), Positives = 426/650 (65%), Gaps = 28/650 (4%)
Query: 36 PQPPEESQPPQSQAQVPPAAPHHHHHHSHSGPEISRIIVDPTTGKRYCRGKVLGKGGFAK 95
P PP PP S + P S G R+I DP +G+ Y +G++LGKGGFA+
Sbjct: 20 PAPPAGPGPPPSALRGPELEMLAGLPTSDPG----RLITDPRSGRTYLKGRLLGKGGFAR 75
Query: 96 CYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQFYHYFEDKENI 155
CYE TD YA K+IP SRVAKPHQREKI EIELHR L H+H+V+F H+FED +NI
Sbjct: 76 CYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVRFSHHFEDADNI 135
Query: 156 YILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINE 215
YI LE CSR+S+AHI KAR L EPEVRYYLRQI+SGLKYLH++ ILHRDLKLGNFFI E
Sbjct: 136 YIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFITE 195
Query: 216 AMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIWALGCVMYTMLL 275
MELKVGDFGLAARLEP E R++TICGTPNY++PEVL +QGHG E+D+W+LGCVMYT+L
Sbjct: 196 NMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEADVWSLGCVMYTLLC 255
Query: 276 GRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFL 335
G PPFET +LKETYRCI++ YT+P+SL PA+ L+A++L +P DRPS+D I+RHDFF
Sbjct: 256 GSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPSIDQILRHDFFT 315
Query: 336 QGFTPDRLSSSCCHTVPDFHLSSPAKNFFKKAAAALFGGKKDKARYIDTHNRVSKEDEDI 395
+G+TPDRL S C TVPD +PA++ F K +LFG KK + ++E +++
Sbjct: 316 KGYTPDRLPISSCVTVPDLTPPNPARSLFAKVTKSLFGRKKKSKNH-------AQERDEV 368
Query: 396 YKLRHDLKKTSITQQPSKHRTDEELQPPTTTVARSGTPAVENKQQIGDAIRMIVRGTLGS 455
L L +TS+ Q ++ P ++ + A E+ RGTL S
Sbjct: 369 SGLVSGLMRTSVGHQDARPEAPAASGPAPVSLVET---APEDSSP---------RGTLAS 416
Query: 456 CSSSSECLEDSTMGSVADTVARVLRGCLENMPEADCIPKEQLSTS-FQWVTKWVDYSNKY 514
E E T+ +V ++ LR C+ MP A+ P WV+KWVDYSNK+
Sbjct: 417 SGDGFE--EGLTVATVVESALCALRNCIAFMPPAEQNPAPLAQPEPLVWVSKWVDYSNKF 474
Query: 515 GFGYQLSDHTVGVLFNNGAHMSLLPDKKTVHYYAELGQCSVFPATDAPEQFISQVTVLKY 574
GFGYQLS V VLFN+G HM+L ++KTVHY + F P Q+ +L+Y
Sbjct: 475 GFGYQLSSRRVAVLFNDGTHMALSANRKTVHYNPTSTKHFSFSVGAVPRALQPQLGILRY 534
Query: 575 FSHYMEENLMDGGDLPSVTDIRRPR-LYLLQWLKSDKALMMLFNDGTFQVNFYHDHTKII 633
F+ YME++LM GGDLPSV ++ P LLQW+K+D+AL+MLF+DGT QVNFY DHTK+I
Sbjct: 535 FASYMEQHLMKGGDLPSVEEVEVPAPPLLLQWVKTDQALLMLFSDGTVQVNFYGDHTKLI 594
Query: 634 ICSQNEEYLLTYINEDRISTTFRLTTLLMSGCSSELKNRMEYALNMLLQR 683
+ S E L+T++ +R + T+ + L GCS +L+ R+ YAL +L R
Sbjct: 595 L-SGWEPLLVTFVARNRSACTYLASHLRQLGCSPDLRQRLRYALRLLRDR 643
>gi|21359873 polo-like kinase 1 [Homo sapiens]
Length = 603
Score = 447 bits (1149), Expect = e-125
Identities = 248/650 (38%), Positives = 361/650 (55%), Gaps = 76/650 (11%)
Query: 33 KRPPQPPEESQPPQSQAQVPPAAPHHHHHHSHSGPEISRIIVDPTTGKRYCRGKVLGKGG 92
+ P P + P + P AAP EI ++VDP + +RY RG+ LGKGG
Sbjct: 12 RAPADPGKAGVPGVAAPGAPAAAP--------PAKEIPEVLVDPRSRRRYVRGRFLGKGG 63
Query: 93 FAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQFYHYFEDK 152
FAKC+E++D +V+A KI+P S + KPHQREK+ EI +HR L H+HVV F+ +FED
Sbjct: 64 FAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDN 123
Query: 153 ENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFF 212
+ ++++LE C RRS+ + K RK LTEPE RYYLRQIV G +YLH ++HRDLKLGN F
Sbjct: 124 DFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLF 183
Query: 213 INEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIWALGCVMYT 272
+NE +E+K+GDFGLA ++E R++T+CGTPNY++PEVL+K+GH E D+W++GC+MYT
Sbjct: 184 LNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYT 243
Query: 273 MLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHD 332
+L+G+PPFET+ LKETY I++ Y++P + A LI ML +P RP++++++ +
Sbjct: 244 LLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDE 303
Query: 333 FFLQGFTPDRLSSSCCHTVPDFHLSSPAKNFFKKAAAALFGGKKDKARYIDTHNRVSKED 392
FF G+ P RL +C P F ++ + +D NR
Sbjct: 304 FFTSGYIPARLPITCLTIPPRFSIAPSS---------------------LDPSNR----- 337
Query: 393 EDIYKLRHDLKKTSITQQPSKHRTDEELQPPTTTVARSGTPAVENKQQIGDAIRMIVRGT 452
K L K P + R EE P V ++ D +
Sbjct: 338 ----KPLTVLNKGLENPLPERPREKEE-------------PVVRETGEVVDCHLSDMLQQ 380
Query: 453 LGSCSSSSECLEDSTMGSVADTVARVLRGCLENMPEADCIPKEQLSTSFQWVTKWVDYSN 512
L S ++S + S G V E + CIP WV+KWVDYS+
Sbjct: 381 LHSVNAS----KPSERGLVRQ----------EEAEDPACIP-------IFWVSKWVDYSD 419
Query: 513 KYGFGYQLSDHTVGVLFNNGAHMSLLPDKKTVHYYAELGQCSVFPATDAPEQFISQVTVL 572
KYG GYQL D++VGVLFN+ + L D ++ Y G S + P + ++T+L
Sbjct: 420 KYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLL 479
Query: 573 KYFSHYMEENLMDGGD--LPSVTDIRRPRLYLLQWLKSDKALMMLFNDGTFQVNFYHDHT 630
KYF +YM E+L+ G P D YL W ++ A+++ ++G+ Q+NF+ DHT
Sbjct: 480 KYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHT 539
Query: 631 KIIICSQNEEYLLTYINEDRISTTFRLTTLLMSGCSSELKNRMEYALNML 680
K+I+C +TYI+E R T+RL+ L GC EL +R+ YA M+
Sbjct: 540 KLILCPLMA--AVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMV 587
>gi|121114283 polo-like kinase 4 [Homo sapiens]
Length = 970
Score = 219 bits (559), Expect = 5e-57
Identities = 104/250 (41%), Positives = 150/250 (60%), Gaps = 1/250 (0%)
Query: 85 GKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQ 144
G +LGKG FA Y + A K+I + K +++ E+++H L H +++
Sbjct: 15 GNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSILE 74
Query: 145 FYHYFEDKENIYILLEYCSRRSMAHILKAR-KVLTEPEVRYYLRQIVSGLKYLHEQEILH 203
Y+YFED +Y++LE C M LK R K +E E R+++ QI++G+ YLH ILH
Sbjct: 75 LYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHGILH 134
Query: 204 RDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDI 263
RDL L N + M +K+ DFGLA +L+ + T+CGTPNY+SPE+ + HG ESD+
Sbjct: 135 RDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLESDV 194
Query: 264 WALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRP 323
W+LGC+ YT+L+GRPPF+T +K T + A Y MPS L AK LI +L +NP DR
Sbjct: 195 WSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLRRNPADRL 254
Query: 324 SLDDIIRHDF 333
SL ++ H F
Sbjct: 255 SLSSVLDHPF 264
>gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]
Length = 661
Score = 173 bits (438), Expect = 5e-43
Identities = 118/390 (30%), Positives = 184/390 (47%), Gaps = 39/390 (10%)
Query: 49 AQVPPAAPH--HHHHHSHSGPEISRIIVDPTTGKRYCRGKVLGKGGFAKCYEMTDLTNNK 106
A + P PH HHH H+ RY + LGKG + K T+ + +
Sbjct: 32 AALEPRKPHGVKRHHHKHN------------LKHRYELQETLGKGTYGKVKRATERFSGR 79
Query: 107 VYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLEYCSRRS 166
V A K I ++ I +EIE+ L+H H++ Y FE+K+ I I++EY S+
Sbjct: 80 VVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPHIISIYEVFENKDKIVIIMEYASKGE 139
Query: 167 MAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMELKVGDFGL 226
+ + R+ L+E E R++ RQIVS + Y H+ ++HRDLKL N +++ +K+ DFGL
Sbjct: 140 LYDYISERRRLSERETRHFFRQIVSAVHYCHKNGVVHRDLKLENILLDDNCNIKIADFGL 199
Query: 227 AARLEPLEHRRRTICGTPNYLSPEVLNKQGH-GCESDIWALGCVMYTMLLGRPPFETTNL 285
+ L + +T CG+P Y SPE++N + + G E D WALG ++YT++ G PF+ +
Sbjct: 200 -SNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEVDSWALGVLLYTLVYGTMPFDGFDH 258
Query: 286 KETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFLQGFTPDRLSS 345
K R I Y P+ + A+ LI ML NP+ R +++DI H + G+ S
Sbjct: 259 KNLIRQISSGEYREPTQ-PSDARGLIRWMLMVNPDRRATIEDIANHWWVNWGY-----KS 312
Query: 346 SCCHTVPDFHLSSPAKNFFKKAAAALFGGKKDKARYIDTHNRVSKEDEDIYKLRHDLKKT 405
S C SP AR ID H+R + D L K
Sbjct: 313 SVCDCDALHDSESPL-----------------LARIIDWHHRSTGLQADTEAKMKGLAKP 355
Query: 406 SITQQPSKHRTDEELQPPTTTVARSGTPAV 435
+ ++ + + + A+SG AV
Sbjct: 356 TTSEVMLERQRSLKKSKKENDFAQSGQDAV 385
>gi|38327572 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 166 bits (419), Expect = 9e-41
Identities = 78/247 (31%), Positives = 134/247 (54%), Gaps = 2/247 (0%)
Query: 85 GKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQ 144
G+ LGKG F Y + + + A K++ +++ K ++ +E+E+ L H ++++
Sbjct: 136 GRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILR 195
Query: 145 FYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHR 204
Y YF D +Y++LEY ++ L+ E Y+ ++ + L Y H + ++HR
Sbjct: 196 LYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHR 255
Query: 205 DLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIW 264
D+K N + A ELK+ DFG + RR T+CGT +YL PE++ + H + D+W
Sbjct: 256 DIKPENLLLGSAGELKIADFGWSVHAP--SSRRTTLCGTLDYLPPEMIEGRMHDEKVDLW 313
Query: 265 ALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPS 324
+LG + Y L+G+PPFE +ETY+ I +T P + A+ LI+ +L NP RP
Sbjct: 314 SLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPM 373
Query: 325 LDDIIRH 331
L +++ H
Sbjct: 374 LREVLEH 380
>gi|38327570 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 166 bits (419), Expect = 9e-41
Identities = 78/247 (31%), Positives = 134/247 (54%), Gaps = 2/247 (0%)
Query: 85 GKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQ 144
G+ LGKG F Y + + + A K++ +++ K ++ +E+E+ L H ++++
Sbjct: 136 GRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILR 195
Query: 145 FYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHR 204
Y YF D +Y++LEY ++ L+ E Y+ ++ + L Y H + ++HR
Sbjct: 196 LYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHR 255
Query: 205 DLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIW 264
D+K N + A ELK+ DFG + RR T+CGT +YL PE++ + H + D+W
Sbjct: 256 DIKPENLLLGSAGELKIADFGWSVHAP--SSRRTTLCGTLDYLPPEMIEGRMHDEKVDLW 313
Query: 265 ALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPS 324
+LG + Y L+G+PPFE +ETY+ I +T P + A+ LI+ +L NP RP
Sbjct: 314 SLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPM 373
Query: 325 LDDIIRH 331
L +++ H
Sbjct: 374 LREVLEH 380
>gi|38327568 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 166 bits (419), Expect = 9e-41
Identities = 78/247 (31%), Positives = 134/247 (54%), Gaps = 2/247 (0%)
Query: 85 GKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQ 144
G+ LGKG F Y + + + A K++ +++ K ++ +E+E+ L H ++++
Sbjct: 136 GRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILR 195
Query: 145 FYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHR 204
Y YF D +Y++LEY ++ L+ E Y+ ++ + L Y H + ++HR
Sbjct: 196 LYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHR 255
Query: 205 DLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIW 264
D+K N + A ELK+ DFG + RR T+CGT +YL PE++ + H + D+W
Sbjct: 256 DIKPENLLLGSAGELKIADFGWSVHAP--SSRRTTLCGTLDYLPPEMIEGRMHDEKVDLW 313
Query: 265 ALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPS 324
+LG + Y L+G+PPFE +ETY+ I +T P + A+ LI+ +L NP RP
Sbjct: 314 SLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPM 373
Query: 325 LDDIIRH 331
L +++ H
Sbjct: 374 LREVLEH 380
>gi|38327566 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 166 bits (419), Expect = 9e-41
Identities = 78/247 (31%), Positives = 134/247 (54%), Gaps = 2/247 (0%)
Query: 85 GKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQ 144
G+ LGKG F Y + + + A K++ +++ K ++ +E+E+ L H ++++
Sbjct: 136 GRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILR 195
Query: 145 FYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHR 204
Y YF D +Y++LEY ++ L+ E Y+ ++ + L Y H + ++HR
Sbjct: 196 LYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHR 255
Query: 205 DLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIW 264
D+K N + A ELK+ DFG + RR T+CGT +YL PE++ + H + D+W
Sbjct: 256 DIKPENLLLGSAGELKIADFGWSVHAP--SSRRTTLCGTLDYLPPEMIEGRMHDEKVDLW 313
Query: 265 ALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPS 324
+LG + Y L+G+PPFE +ETY+ I +T P + A+ LI+ +L NP RP
Sbjct: 314 SLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPM 373
Query: 325 LDDIIRH 331
L +++ H
Sbjct: 374 LREVLEH 380
>gi|38327564 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 166 bits (419), Expect = 9e-41
Identities = 78/247 (31%), Positives = 134/247 (54%), Gaps = 2/247 (0%)
Query: 85 GKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQ 144
G+ LGKG F Y + + + A K++ +++ K ++ +E+E+ L H ++++
Sbjct: 136 GRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILR 195
Query: 145 FYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHR 204
Y YF D +Y++LEY ++ L+ E Y+ ++ + L Y H + ++HR
Sbjct: 196 LYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHR 255
Query: 205 DLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIW 264
D+K N + A ELK+ DFG + RR T+CGT +YL PE++ + H + D+W
Sbjct: 256 DIKPENLLLGSAGELKIADFGWSVHAP--SSRRTTLCGTLDYLPPEMIEGRMHDEKVDLW 313
Query: 265 ALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPS 324
+LG + Y L+G+PPFE +ETY+ I +T P + A+ LI+ +L NP RP
Sbjct: 314 SLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPM 373
Query: 325 LDDIIRH 331
L +++ H
Sbjct: 374 LREVLEH 380
>gi|38327562 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 166 bits (419), Expect = 9e-41
Identities = 78/247 (31%), Positives = 134/247 (54%), Gaps = 2/247 (0%)
Query: 85 GKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQ 144
G+ LGKG F Y + + + A K++ +++ K ++ +E+E+ L H ++++
Sbjct: 136 GRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILR 195
Query: 145 FYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHR 204
Y YF D +Y++LEY ++ L+ E Y+ ++ + L Y H + ++HR
Sbjct: 196 LYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHR 255
Query: 205 DLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIW 264
D+K N + A ELK+ DFG + RR T+CGT +YL PE++ + H + D+W
Sbjct: 256 DIKPENLLLGSAGELKIADFGWSVHAP--SSRRTTLCGTLDYLPPEMIEGRMHDEKVDLW 313
Query: 265 ALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPS 324
+LG + Y L+G+PPFE +ETY+ I +T P + A+ LI+ +L NP RP
Sbjct: 314 SLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPM 373
Query: 325 LDDIIRH 331
L +++ H
Sbjct: 374 LREVLEH 380
>gi|83776600 aurora kinase B [Homo sapiens]
Length = 344
Score = 164 bits (414), Expect = 3e-40
Identities = 94/300 (31%), Positives = 155/300 (51%), Gaps = 5/300 (1%)
Query: 32 KKRPPQPPEESQPPQSQAQVPPAAPHHHHHHSHSGPEISRIIVDPTTGKRYCRGKVLGKG 91
+K P P +S Q P AAP + SG I+ T + G+ LGKG
Sbjct: 30 RKEPVTPSALVLMSRSNVQ-PTAAPGQKVMENSSGTP--DILTRHFTIDDFEIGRPLGKG 86
Query: 92 GFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQFYHYFED 151
F Y + ++ + A K++ S++ K ++ +EIE+ LHH ++++ Y+YF D
Sbjct: 87 KFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYD 146
Query: 152 KENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNF 211
+ IY++LEY R + L+ E + ++ L Y H ++++HRD+K N
Sbjct: 147 RRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENL 206
Query: 212 FINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIWALGCVMY 271
+ ELK+ DFG + L RR+T+CGT +YL PE++ + H + D+W +G + Y
Sbjct: 207 LLGLKGELKIADFGWSVHAPSL--RRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCY 264
Query: 272 TMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRH 331
+L+G PPFE+ + ETYR I + P+S+ A+ LI+ +L NP +R L + H
Sbjct: 265 ELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAH 324
>gi|62865641 aurora kinase C isoform 2 [Homo sapiens]
Length = 290
Score = 156 bits (395), Expect = 5e-38
Identities = 83/267 (31%), Positives = 145/267 (54%), Gaps = 7/267 (2%)
Query: 65 SGPEISRIIVDPTTGKRYCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQR 124
S P + R+ VD + G+ LGKG F Y ++ + A K++ S++ K
Sbjct: 12 SSPAMRRLTVDD-----FEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLE 66
Query: 125 EKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRY 184
++ +EIE+ L H ++++ Y+YF D +Y++LEY R + L+ + L E
Sbjct: 67 HQLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTAT 126
Query: 185 YLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTP 244
+ ++ L Y H+++++HRD+K N + E+K+ DFG + L RR+T+CGT
Sbjct: 127 IIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSL--RRKTMCGTL 184
Query: 245 NYLSPEVLNKQGHGCESDIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLL 304
+YL PE++ + + + D+W +G + Y +L+G PPFE+ + ETYR I + P S+
Sbjct: 185 DYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMP 244
Query: 305 APAKHLIASMLSKNPEDRPSLDDIIRH 331
A+ LI+ +L P +R L I++H
Sbjct: 245 LGARDLISRLLRYQPLERLPLAQILKH 271
>gi|62865639 aurora kinase C isoform 1 [Homo sapiens]
Length = 309
Score = 156 bits (395), Expect = 5e-38
Identities = 83/267 (31%), Positives = 145/267 (54%), Gaps = 7/267 (2%)
Query: 65 SGPEISRIIVDPTTGKRYCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQR 124
S P + R+ VD + G+ LGKG F Y ++ + A K++ S++ K
Sbjct: 31 SSPAMRRLTVDD-----FEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLE 85
Query: 125 EKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRY 184
++ +EIE+ L H ++++ Y+YF D +Y++LEY R + L+ + L E
Sbjct: 86 HQLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTAT 145
Query: 185 YLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTP 244
+ ++ L Y H+++++HRD+K N + E+K+ DFG + L RR+T+CGT
Sbjct: 146 IIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSL--RRKTMCGTL 203
Query: 245 NYLSPEVLNKQGHGCESDIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLL 304
+YL PE++ + + + D+W +G + Y +L+G PPFE+ + ETYR I + P S+
Sbjct: 204 DYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMP 263
Query: 305 APAKHLIASMLSKNPEDRPSLDDIIRH 331
A+ LI+ +L P +R L I++H
Sbjct: 264 LGARDLISRLLRYQPLERLPLAQILKH 290
>gi|62865643 aurora kinase C isoform 3 [Homo sapiens]
Length = 275
Score = 154 bits (390), Expect = 2e-37
Identities = 78/247 (31%), Positives = 137/247 (55%), Gaps = 2/247 (0%)
Query: 85 GKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQ 144
G+ LGKG F Y ++ + A K++ S++ K ++ +EIE+ L H ++++
Sbjct: 12 GRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILR 71
Query: 145 FYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHR 204
Y+YF D +Y++LEY R + L+ + L E + ++ L Y H+++++HR
Sbjct: 72 LYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKVIHR 131
Query: 205 DLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIW 264
D+K N + E+K+ DFG + L RR+T+CGT +YL PE++ + + + D+W
Sbjct: 132 DIKPENLLLGFRGEVKIADFGWSVHTPSL--RRKTMCGTLDYLPPEMIEGRTYDEKVDLW 189
Query: 265 ALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPS 324
+G + Y +L+G PPFE+ + ETYR I + P S+ A+ LI+ +L P +R
Sbjct: 190 CIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLP 249
Query: 325 LDDIIRH 331
L I++H
Sbjct: 250 LAQILKH 256
>gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo
sapiens]
Length = 795
Score = 154 bits (388), Expect = 3e-37
Identities = 85/269 (31%), Positives = 148/269 (55%), Gaps = 6/269 (2%)
Query: 86 KVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQF 145
K +GKG FAK + + A KII +++ P +K+ +E+ + +IL+H ++V+
Sbjct: 64 KTIGKGNFAKVKLARHVLTGREVAVKIIDKTQL-NPTSLQKLFREVRIMKILNHPNIVKL 122
Query: 146 YHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRD 205
+ E ++ +Y+++EY S + L A + E E R RQIVS ++Y H++ I+HRD
Sbjct: 123 FEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIVHRD 182
Query: 206 LKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVL-NKQGHGCESDIW 264
LK N ++ M +K+ DFG + + ++ T CG+P Y +PE+ K+ G E D+W
Sbjct: 183 LKAENLLLDGDMNIKIADFGFSNEF-TVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVW 241
Query: 265 ALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPS 324
+LG ++YT++ G PF+ NLKE + +Y +P + ++L+ +L NP R S
Sbjct: 242 SLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKRGS 301
Query: 325 LDDIIRHDFFLQGFTPDRLSSSCCHTVPD 353
L+ I++ + G + L +T PD
Sbjct: 302 LEQIMKDRWMNVGHEEEELKP---YTEPD 327
>gi|193083129 MAP/microtubule affinity-regulating kinase 3 isoform d
[Homo sapiens]
Length = 713
Score = 153 bits (387), Expect = 4e-37
Identities = 126/482 (26%), Positives = 221/482 (45%), Gaps = 45/482 (9%)
Query: 86 KVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQF 145
K +GKG FAK + + A KII +++ P +K+ +E+ + +IL+H ++V+
Sbjct: 60 KTIGKGNFAKVKLARHILTGREVAIKIIDKTQL-NPTSLQKLFREVRIMKILNHPNIVKL 118
Query: 146 YHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRD 205
+ E ++ +Y+++EY S + L A + E E R RQIVS ++Y H++ I+HRD
Sbjct: 119 FEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRD 178
Query: 206 LKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVL-NKQGHGCESDIW 264
LK N ++ M +K+ DFG + + + T CG+P Y +PE+ K+ G E D+W
Sbjct: 179 LKAENLLLDADMNIKIADFGFSNEF-TVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVW 237
Query: 265 ALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPS 324
+LG ++YT++ G PF+ NLKE + +Y +P + ++L+ L NP R +
Sbjct: 238 SLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGT 297
Query: 325 LDDIIRHDFFLQGFTPDRLSSSCCHTVPDFHLSSPAKNFFKKAAAALFGGKKDKARYIDT 384
L+ I++ + G D L P+ +S +K + G + ++
Sbjct: 298 LEQIMKDRWINAGHEEDELKP---FVEPELDISD------QKRIDIMVGMGYSQEEIQES 348
Query: 385 HNRVSKEDEDIYKLRHDLKKTSITQQPSKHRTDEELQPPTTTVARSGTPAVENKQ---QI 441
+++ ++ L K + + +PS + Q P V RS + + ++
Sbjct: 349 LSKMKYDEITATYLLLGRKSSEV--RPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSDHA 406
Query: 442 GDAIRMIVRGTLGSCSSS--SECLED---------STMGSVADTVARVLRGCLENMPEAD 490
G AI +V S +S+ S+ ED S +G A + G N +AD
Sbjct: 407 GPAIPSVVAYPKRSQTSTADSDLKEDGISSRKSSGSAVGGKGIAPASPMLGNASNPNKAD 466
Query: 491 CIPKEQLSTSFQWVTKWVDYSNKYGFG------YQLSDHTVG---VLFNNGAHMSLLPDK 541
+++ ST V SN G Y S+ T + NG S +PD+
Sbjct: 467 IPERKKSST--------VPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQ 518
Query: 542 KT 543
+T
Sbjct: 519 RT 520
>gi|193083127 MAP/microtubule affinity-regulating kinase 3 isoform b
[Homo sapiens]
Length = 744
Score = 152 bits (385), Expect = 8e-37
Identities = 82/259 (31%), Positives = 142/259 (54%), Gaps = 3/259 (1%)
Query: 86 KVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQF 145
K +GKG FAK + + A KII +++ P +K+ +E+ + +IL+H ++V+
Sbjct: 60 KTIGKGNFAKVKLARHILTGREVAIKIIDKTQL-NPTSLQKLFREVRIMKILNHPNIVKL 118
Query: 146 YHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRD 205
+ E ++ +Y+++EY S + L A + E E R RQIVS ++Y H++ I+HRD
Sbjct: 119 FEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRD 178
Query: 206 LKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVL-NKQGHGCESDIW 264
LK N ++ M +K+ DFG + + + T CG+P Y +PE+ K+ G E D+W
Sbjct: 179 LKAENLLLDADMNIKIADFGFSNEF-TVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVW 237
Query: 265 ALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPS 324
+LG ++YT++ G PF+ NLKE + +Y +P + ++L+ L NP R +
Sbjct: 238 SLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGT 297
Query: 325 LDDIIRHDFFLQGFTPDRL 343
L+ I++ + G D L
Sbjct: 298 LEQIMKDRWINAGHEEDEL 316
>gi|193083125 MAP/microtubule affinity-regulating kinase 3 isoform a
[Homo sapiens]
Length = 753
Score = 152 bits (385), Expect = 8e-37
Identities = 82/259 (31%), Positives = 142/259 (54%), Gaps = 3/259 (1%)
Query: 86 KVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQF 145
K +GKG FAK + + A KII +++ P +K+ +E+ + +IL+H ++V+
Sbjct: 60 KTIGKGNFAKVKLARHILTGREVAIKIIDKTQL-NPTSLQKLFREVRIMKILNHPNIVKL 118
Query: 146 YHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRD 205
+ E ++ +Y+++EY S + L A + E E R RQIVS ++Y H++ I+HRD
Sbjct: 119 FEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRD 178
Query: 206 LKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVL-NKQGHGCESDIW 264
LK N ++ M +K+ DFG + + + T CG+P Y +PE+ K+ G E D+W
Sbjct: 179 LKAENLLLDADMNIKIADFGFSNEF-TVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVW 237
Query: 265 ALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPS 324
+LG ++YT++ G PF+ NLKE + +Y +P + ++L+ L NP R +
Sbjct: 238 SLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGT 297
Query: 325 LDDIIRHDFFLQGFTPDRL 343
L+ I++ + G D L
Sbjct: 298 LEQIMKDRWINAGHEEDEL 316
>gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform c
[Homo sapiens]
Length = 729
Score = 152 bits (385), Expect = 8e-37
Identities = 82/259 (31%), Positives = 142/259 (54%), Gaps = 3/259 (1%)
Query: 86 KVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQF 145
K +GKG FAK + + A KII +++ P +K+ +E+ + +IL+H ++V+
Sbjct: 60 KTIGKGNFAKVKLARHILTGREVAIKIIDKTQL-NPTSLQKLFREVRIMKILNHPNIVKL 118
Query: 146 YHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRD 205
+ E ++ +Y+++EY S + L A + E E R RQIVS ++Y H++ I+HRD
Sbjct: 119 FEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRD 178
Query: 206 LKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVL-NKQGHGCESDIW 264
LK N ++ M +K+ DFG + + + T CG+P Y +PE+ K+ G E D+W
Sbjct: 179 LKAENLLLDADMNIKIADFGFSNEF-TVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVW 237
Query: 265 ALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPS 324
+LG ++YT++ G PF+ NLKE + +Y +P + ++L+ L NP R +
Sbjct: 238 SLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGT 297
Query: 325 LDDIIRHDFFLQGFTPDRL 343
L+ I++ + G D L
Sbjct: 298 LEQIMKDRWINAGHEEDEL 316
>gi|254028240 MAP/microtubule affinity-regulating kinase 2 isoform f
[Homo sapiens]
Length = 709
Score = 151 bits (382), Expect = 2e-36
Identities = 81/259 (31%), Positives = 141/259 (54%), Gaps = 3/259 (1%)
Query: 86 KVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQF 145
K +GKG FAK + K A KII +++ +K+ +E+ + ++L+H ++V+
Sbjct: 57 KTIGKGNFAKVKLARHILTGKEVAVKIIDKTQL-NSSSLQKLFREVRIMKVLNHPNIVKL 115
Query: 146 YHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRD 205
+ E ++ +Y+++EY S + L A + E E R RQIVS ++Y H++ I+HRD
Sbjct: 116 FEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRD 175
Query: 206 LKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVL-NKQGHGCESDIW 264
LK N ++ M +K+ DFG + ++ T CG+P Y +PE+ K+ G E D+W
Sbjct: 176 LKAENLLLDADMNIKIADFGFSNEF-TFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVW 234
Query: 265 ALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPS 324
+LG ++YT++ G PF+ NLKE + +Y +P + ++L+ L NP R +
Sbjct: 235 SLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGT 294
Query: 325 LDDIIRHDFFLQGFTPDRL 343
L+ I++ + G D L
Sbjct: 295 LEQIMKDRWMNVGHEDDEL 313
>gi|254028237 MAP/microtubule affinity-regulating kinase 2 isoform e
[Homo sapiens]
Length = 719
Score = 151 bits (382), Expect = 2e-36
Identities = 81/259 (31%), Positives = 141/259 (54%), Gaps = 3/259 (1%)
Query: 86 KVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQF 145
K +GKG FAK + K A KII +++ +K+ +E+ + ++L+H ++V+
Sbjct: 57 KTIGKGNFAKVKLARHILTGKEVAVKIIDKTQL-NSSSLQKLFREVRIMKVLNHPNIVKL 115
Query: 146 YHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRD 205
+ E ++ +Y+++EY S + L A + E E R RQIVS ++Y H++ I+HRD
Sbjct: 116 FEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRD 175
Query: 206 LKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVL-NKQGHGCESDIW 264
LK N ++ M +K+ DFG + ++ T CG+P Y +PE+ K+ G E D+W
Sbjct: 176 LKAENLLLDADMNIKIADFGFSNEF-TFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVW 234
Query: 265 ALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPS 324
+LG ++YT++ G PF+ NLKE + +Y +P + ++L+ L NP R +
Sbjct: 235 SLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGT 294
Query: 325 LDDIIRHDFFLQGFTPDRL 343
L+ I++ + G D L
Sbjct: 295 LEQIMKDRWMNVGHEDDEL 313
>gi|254028234 MAP/microtubule affinity-regulating kinase 2 isoform d
[Homo sapiens]
Length = 788
Score = 151 bits (382), Expect = 2e-36
Identities = 81/259 (31%), Positives = 141/259 (54%), Gaps = 3/259 (1%)
Query: 86 KVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQF 145
K +GKG FAK + K A KII +++ +K+ +E+ + ++L+H ++V+
Sbjct: 57 KTIGKGNFAKVKLARHILTGKEVAVKIIDKTQL-NSSSLQKLFREVRIMKVLNHPNIVKL 115
Query: 146 YHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRD 205
+ E ++ +Y+++EY S + L A + E E R RQIVS ++Y H++ I+HRD
Sbjct: 116 FEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRD 175
Query: 206 LKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVL-NKQGHGCESDIW 264
LK N ++ M +K+ DFG + ++ T CG+P Y +PE+ K+ G E D+W
Sbjct: 176 LKAENLLLDADMNIKIADFGFSNEF-TFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVW 234
Query: 265 ALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPS 324
+LG ++YT++ G PF+ NLKE + +Y +P + ++L+ L NP R +
Sbjct: 235 SLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGT 294
Query: 325 LDDIIRHDFFLQGFTPDRL 343
L+ I++ + G D L
Sbjct: 295 LEQIMKDRWMNVGHEDDEL 313
>gi|254028232 MAP/microtubule affinity-regulating kinase 2 isoform c
[Homo sapiens]
Length = 724
Score = 151 bits (382), Expect = 2e-36
Identities = 81/259 (31%), Positives = 141/259 (54%), Gaps = 3/259 (1%)
Query: 86 KVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQF 145
K +GKG FAK + K A KII +++ +K+ +E+ + ++L+H ++V+
Sbjct: 57 KTIGKGNFAKVKLARHILTGKEVAVKIIDKTQL-NSSSLQKLFREVRIMKVLNHPNIVKL 115
Query: 146 YHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRD 205
+ E ++ +Y+++EY S + L A + E E R RQIVS ++Y H++ I+HRD
Sbjct: 116 FEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRD 175
Query: 206 LKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVL-NKQGHGCESDIW 264
LK N ++ M +K+ DFG + ++ T CG+P Y +PE+ K+ G E D+W
Sbjct: 176 LKAENLLLDADMNIKIADFGFSNEF-TFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVW 234
Query: 265 ALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPS 324
+LG ++YT++ G PF+ NLKE + +Y +P + ++L+ L NP R +
Sbjct: 235 SLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGT 294
Query: 325 LDDIIRHDFFLQGFTPDRL 343
L+ I++ + G D L
Sbjct: 295 LEQIMKDRWMNVGHEDDEL 313
>gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform a
[Homo sapiens]
Length = 745
Score = 151 bits (382), Expect = 2e-36
Identities = 81/259 (31%), Positives = 141/259 (54%), Gaps = 3/259 (1%)
Query: 86 KVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQF 145
K +GKG FAK + K A KII +++ +K+ +E+ + ++L+H ++V+
Sbjct: 24 KTIGKGNFAKVKLARHILTGKEVAVKIIDKTQL-NSSSLQKLFREVRIMKVLNHPNIVKL 82
Query: 146 YHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRD 205
+ E ++ +Y+++EY S + L A + E E R RQIVS ++Y H++ I+HRD
Sbjct: 83 FEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRD 142
Query: 206 LKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVL-NKQGHGCESDIW 264
LK N ++ M +K+ DFG + ++ T CG+P Y +PE+ K+ G E D+W
Sbjct: 143 LKAENLLLDADMNIKIADFGFSNEF-TFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVW 201
Query: 265 ALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPS 324
+LG ++YT++ G PF+ NLKE + +Y +P + ++L+ L NP R +
Sbjct: 202 SLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGT 261
Query: 325 LDDIIRHDFFLQGFTPDRL 343
L+ I++ + G D L
Sbjct: 262 LEQIMKDRWMNVGHEDDEL 280
>gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens]
Length = 651
Score = 149 bits (377), Expect = 6e-36
Identities = 83/261 (31%), Positives = 142/261 (54%), Gaps = 4/261 (1%)
Query: 80 KRYCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHH 139
K Y + +G GGFAK + ++ A KI+ + + R I EIE + L H
Sbjct: 9 KYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPR--IKTEIEALKNLRH 66
Query: 140 KHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQ 199
+H+ Q YH E I+++LEYC + + ++ L+E E R RQIVS + Y+H Q
Sbjct: 67 QHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQ 126
Query: 200 EILHRDLKLGNFFINEAMELKVGDFGLAARLE-PLEHRRRTICGTPNYLSPEVLNKQGH- 257
HRDLK N +E +LK+ DFGL A+ + ++ +T CG+ Y +PE++ + +
Sbjct: 127 GYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYL 186
Query: 258 GCESDIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSK 317
G E+D+W++G ++Y ++ G PF+ N+ Y+ I +Y +P L + L+ ML
Sbjct: 187 GSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQV 246
Query: 318 NPEDRPSLDDIIRHDFFLQGF 338
+P+ R S+ +++ H + +Q +
Sbjct: 247 DPKKRISMKNLLNHPWIMQDY 267
>gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform a [Homo sapiens]
Length = 735
Score = 148 bits (374), Expect = 1e-35
Identities = 92/313 (29%), Positives = 162/313 (51%), Gaps = 22/313 (7%)
Query: 36 PQPPEESQPPQSQAQVPPAAPH------HHHHHSHSGPEISRIIVDPTTGKRYCRGKVLG 89
P PE Q +A + P+ HH +G E + DP+ + KVLG
Sbjct: 17 PLDPENGQTSGEEAGLQPSKDEGVLKEISITHHVKAGSEKA----DPSHFELL---KVLG 69
Query: 90 KGGFAKCYEMTDLT---NNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQFY 146
+G F K + + +T + +YA K++ + + K R + E ++ ++H VV+ +
Sbjct: 70 QGSFGKVFLVRKVTRPDSGHLYAMKVLKKATL-KVRDRVRTKMERDILADVNHPFVVKLH 128
Query: 147 HYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDL 206
+ F+ + +Y++L++ + L + TE +V++YL ++ GL +LH I++RDL
Sbjct: 129 YAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDL 188
Query: 207 KLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIWAL 266
K N ++E +K+ DFGL+ E + + CGT Y++PEV+N+QGH +D W+
Sbjct: 189 KPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSY 248
Query: 267 GCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDR---- 322
G +M+ ML G PF+ + KET I +A+ MP L A+ L+ ++ +NP +R
Sbjct: 249 GVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSG 308
Query: 323 -PSLDDIIRHDFF 334
++I RH F+
Sbjct: 309 PDGAEEIKRHVFY 321
Score = 115 bits (288), Expect = 1e-25
Identities = 75/267 (28%), Positives = 133/267 (49%), Gaps = 19/267 (7%)
Query: 82 YCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIE-LHRILHHK 140
Y + +G G +++C N YA K+I S+ +EIE L R H
Sbjct: 418 YVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSK-------RDPSEEIEILLRYGQHP 470
Query: 141 HVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQE 200
+++ ++D +++Y++ E + + +K +E E + L I ++YLH Q
Sbjct: 471 NIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQG 530
Query: 201 ILHRDLKLGNF-FINEAME---LKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQG 256
++HRDLK N +++E+ L++ DFG A +L T C T N+++PEVL +QG
Sbjct: 531 VVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQG 590
Query: 257 HGCESDIWALGCVMYTMLLGRPPF---ETTNLKETYRCIREARYTMP----SSLLAPAKH 309
+ DIW+LG ++YTML G PF + +E I ++T+ +++ AK
Sbjct: 591 YDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKD 650
Query: 310 LIASMLSKNPEDRPSLDDIIRHDFFLQ 336
L++ ML +P R + +++H + Q
Sbjct: 651 LVSKMLHVDPHQRLTAKQVLQHPWVTQ 677
>gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo
sapiens]
Length = 740
Score = 148 bits (373), Expect = 2e-35
Identities = 86/308 (27%), Positives = 160/308 (51%), Gaps = 21/308 (6%)
Query: 36 PQPPEESQPPQSQAQVPPAAPHHHHHHSHSGPEISRIIVDPTTGKRYCRGKVLGKGGFAK 95
P EE P + + A HH H + S+ + KVLG+G F K
Sbjct: 32 PMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELL----------KVLGQGSFGK 81
Query: 96 CYEMTDLTNN---KVYAAKIIPHSRV-AKPHQREKIDKEIELHRILHHKHVVQFYHYFED 151
+ + ++ + ++YA K++ + + + R K++++I + ++H +V+ ++ F+
Sbjct: 82 VFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVE--VNHPFIVKLHYAFQT 139
Query: 152 KENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNF 211
+ +Y++L++ + L + TE +V++YL ++ L +LH I++RDLK N
Sbjct: 140 EGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENI 199
Query: 212 FINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIWALGCVMY 271
++E +K+ DFGL+ E + + CGT Y++PEV+N++GH +D W+ G +M+
Sbjct: 200 LLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMF 259
Query: 272 TMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDR-----PSLD 326
ML G PF+ + KET I +A+ MP L A+ L+ + +NP +R ++
Sbjct: 260 EMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVE 319
Query: 327 DIIRHDFF 334
+I RH FF
Sbjct: 320 EIKRHSFF 327
Score = 108 bits (271), Expect = 1e-23
Identities = 71/259 (27%), Positives = 127/259 (49%), Gaps = 17/259 (6%)
Query: 88 LGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQFYH 147
+G G ++ C N +A KII S+ R+ ++ L R H +++
Sbjct: 428 IGVGSYSVCKRCIHKATNMEFAVKIIDKSK------RDPTEEIEILLRYGQHPNIITLKD 481
Query: 148 YFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLK 207
++D + +Y++ E + + +K +E E L I ++YLH Q ++HRDLK
Sbjct: 482 VYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLK 541
Query: 208 LGNF-FINEA---MELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDI 263
N +++E+ +++ DFG A +L T C T N+++PEVL +QG+ DI
Sbjct: 542 PSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDI 601
Query: 264 WALGCVMYTMLLGRPPFET---TNLKETYRCIREARYTMP----SSLLAPAKHLIASMLS 316
W+LG ++YTML G PF +E I ++++ +S+ AK L++ ML
Sbjct: 602 WSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLH 661
Query: 317 KNPEDRPSLDDIIRHDFFL 335
+P R + ++RH + +
Sbjct: 662 VDPHQRLTAALVLRHPWIV 680
>gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]
Length = 778
Score = 148 bits (373), Expect = 2e-35
Identities = 89/286 (31%), Positives = 155/286 (54%), Gaps = 12/286 (4%)
Query: 55 APHHHHHHSHSGPEISRIIVDPTTGKRYCRGKVLGKG--GFAKCYEMTDLTNNKVYAAKI 112
+P +H H H P V P Y K LGKG G K + +T KV A KI
Sbjct: 12 SPAYHLPHPHPHPPQHAQYVGP-----YRLEKTLGKGQTGLVKL-GVHCITGQKV-AIKI 64
Query: 113 IPHSRVAKPHQREKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILK 172
+ ++++ K+++EI + +++ H HV++ + +E+K+ +Y++LE+ S + L
Sbjct: 65 VNREKLSESVLM-KVEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLV 123
Query: 173 ARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMELKVGDFGLAARLEP 232
+ LT E R + RQIVS L + H I HRDLK N ++E +++ DFG+A+ L+
Sbjct: 124 KKGRLTPKEARKFFRQIVSALDFCHSYSICHRDLKPENLLLDEKNNIRIADFGMAS-LQV 182
Query: 233 LEHRRRTICGTPNYLSPEVLNKQGH-GCESDIWALGCVMYTMLLGRPPFETTNLKETYRC 291
+ T CG+P+Y PEV+ + + G +D+W+ G +++ +L+G PF+ NL++
Sbjct: 183 GDSLLETSCGSPHYACPEVIKGEKYDGRRADMWSCGVILFALLVGALPFDDDNLRQLLEK 242
Query: 292 IREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFLQG 337
++ + MP + + L+ M+ PE R SL+ I +H ++L G
Sbjct: 243 VKRGVFHMPHFIPPDCQSLLRGMIEVEPEKRLSLEQIQKHPWYLGG 288
>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform b [Homo sapiens]
Length = 744
Score = 147 bits (371), Expect = 3e-35
Identities = 93/322 (28%), Positives = 163/322 (50%), Gaps = 31/322 (9%)
Query: 36 PQPPEESQPPQSQAQVPPAAPHHHH---------------HHSHSGPEISRIIVDPTTGK 80
P P + +P SQ +P P HH +G E + DP+ +
Sbjct: 17 PWLPRKQRPRISQTSLPVPGPGSGPQRDSDEGVLKEISITHHVKAGSEKA----DPSHFE 72
Query: 81 RYCRGKVLGKGGFAKCYEMTDLT---NNKVYAAKIIPHSRVAKPHQREKIDKEIELHRIL 137
KVLG+G F K + + +T + +YA K++ + + K R + E ++ +
Sbjct: 73 LL---KVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATL-KVRDRVRTKMERDILADV 128
Query: 138 HHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLH 197
+H VV+ ++ F+ + +Y++L++ + L + TE +V++YL ++ GL +LH
Sbjct: 129 NHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLH 188
Query: 198 EQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGH 257
I++RDLK N ++E +K+ DFGL+ E + + CGT Y++PEV+N+QGH
Sbjct: 189 SLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGH 248
Query: 258 GCESDIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSK 317
+D W+ G +M+ ML G PF+ + KET I +A+ MP L A+ L+ ++ +
Sbjct: 249 SHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKR 308
Query: 318 NPEDR-----PSLDDIIRHDFF 334
NP +R ++I RH F+
Sbjct: 309 NPANRLGSGPDGAEEIKRHVFY 330
Score = 115 bits (288), Expect = 1e-25
Identities = 75/267 (28%), Positives = 133/267 (49%), Gaps = 19/267 (7%)
Query: 82 YCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIE-LHRILHHK 140
Y + +G G +++C N YA K+I S+ +EIE L R H
Sbjct: 427 YVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSK-------RDPSEEIEILLRYGQHP 479
Query: 141 HVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQE 200
+++ ++D +++Y++ E + + +K +E E + L I ++YLH Q
Sbjct: 480 NIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQG 539
Query: 201 ILHRDLKLGNF-FINEAME---LKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQG 256
++HRDLK N +++E+ L++ DFG A +L T C T N+++PEVL +QG
Sbjct: 540 VVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQG 599
Query: 257 HGCESDIWALGCVMYTMLLGRPPF---ETTNLKETYRCIREARYTMP----SSLLAPAKH 309
+ DIW+LG ++YTML G PF + +E I ++T+ +++ AK
Sbjct: 600 YDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKD 659
Query: 310 LIASMLSKNPEDRPSLDDIIRHDFFLQ 336
L++ ML +P R + +++H + Q
Sbjct: 660 LVSKMLHVDPHQRLTAKQVLQHPWVTQ 686
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.408
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,524,305
Number of Sequences: 37866
Number of extensions: 1395551
Number of successful extensions: 10478
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 757
Number of HSP's successfully gapped in prelim test: 142
Number of HSP's that attempted gapping in prelim test: 7465
Number of HSP's gapped (non-prelim): 1663
length of query: 685
length of database: 18,247,518
effective HSP length: 109
effective length of query: 576
effective length of database: 14,120,124
effective search space: 8133191424
effective search space used: 8133191424
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.