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Search of human proteins with 92091600
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|92091600 ArfGAP with RhoGAP domain, ankyrin repeat and PH
domain 1 isoform c [Homo sapiens]
(1450 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|92091600 ArfGAP with RhoGAP domain, ankyrin repeat and PH dom... 2951 0.0
gi|206597513 ArfGAP with RhoGAP domain, ankyrin repeat and PH do... 2437 0.0
gi|206597515 ArfGAP with RhoGAP domain, ankyrin repeat and PH do... 1572 0.0
gi|21264592 ArfGAP with RhoGAP domain, ankyrin repeat and PH dom... 847 0.0
gi|21264337 ArfGAP with RhoGAP domain, ankyrin repeat and PH dom... 763 0.0
gi|7661962 centaurin, gamma 1 isoform PIKE-S [Homo sapiens] 104 5e-22
gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH doma... 103 9e-22
gi|170650694 centaurin, gamma 1 isoform PIKE-L [Homo sapiens] 102 3e-21
gi|224458284 Rho GTPase activating protein 23 [Homo sapiens] 100 2e-20
gi|150417981 glucocorticoid receptor DNA binding factor 1 [Homo ... 99 3e-20
gi|194272142 myosin IXB isoform 2 [Homo sapiens] 97 9e-20
gi|33356170 myosin IXB isoform 1 [Homo sapiens] 97 9e-20
gi|156119615 myosin IXA [Homo sapiens] 97 1e-19
gi|226693398 Rho GTPase activating protein 27 isoform b [Homo sa... 96 3e-19
gi|40548322 Rho GTPase activating protein 27 isoform a [Homo sap... 96 3e-19
gi|206597522 ArfGAP with SH3 domain, ankyrin repeat and PH domai... 96 3e-19
gi|4502249 ArfGAP with SH3 domain, ankyrin repeat and PH domain ... 96 3e-19
gi|46094081 development and differentiation enhancing factor 1 [... 95 6e-19
gi|187608516 centaurin, beta 2 [Homo sapiens] 95 6e-19
gi|34013590 Rho GTPase activating protein 2 [Homo sapiens] 95 6e-19
gi|110227613 centaurin, gamma 3 isoform a [Homo sapiens] 92 3e-18
gi|203097003 Rho GTPase activating protein 21 [Homo sapiens] 92 3e-18
gi|188497642 ARHGAP15 [Homo sapiens] 92 5e-18
gi|47834348 minor histocompatibility antigen HA-1 [Homo sapiens] 91 8e-18
gi|71834863 Rho GTPase activating protein 5 isoform a [Homo sapi... 91 8e-18
gi|71834861 Rho GTPase activating protein 5 isoform b [Homo sapi... 91 8e-18
gi|221307473 ArfGAP with SH3 domain, ankyrin repeat and PH domai... 91 1e-17
gi|19923540 ArfGAP with SH3 domain, ankyrin repeat and PH domain... 91 1e-17
gi|56119110 family with sequence similarity 13, member A1 isofor... 91 1e-17
gi|208022687 GTPase regulator associated with the focal adhesion... 88 5e-17
>gi|92091600 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
isoform c [Homo sapiens]
Length = 1450
Score = 2951 bits (7651), Expect = 0.0
Identities = 1450/1450 (100%), Positives = 1450/1450 (100%)
Query: 1 MAEAGDAALSVAEWLRALHLEQYTGLFEQHGLVWATECQGLSDTRLMDMGMLLPGHRRRI 60
MAEAGDAALSVAEWLRALHLEQYTGLFEQHGLVWATECQGLSDTRLMDMGMLLPGHRRRI
Sbjct: 1 MAEAGDAALSVAEWLRALHLEQYTGLFEQHGLVWATECQGLSDTRLMDMGMLLPGHRRRI 60
Query: 61 LAGLLRAHTSPAPAPRPTPRPVPMKRHIFRSPPVPATPPEPLPTTTEDEGLPAAPPIPPR 120
LAGLLRAHTSPAPAPRPTPRPVPMKRHIFRSPPVPATPPEPLPTTTEDEGLPAAPPIPPR
Sbjct: 61 LAGLLRAHTSPAPAPRPTPRPVPMKRHIFRSPPVPATPPEPLPTTTEDEGLPAAPPIPPR 120
Query: 121 RSCLPPTCFTTPSTAAPDPVLPPLPAKRHLAELSVPPVPPRTGPPRLLVSLPTKEEESLL 180
RSCLPPTCFTTPSTAAPDPVLPPLPAKRHLAELSVPPVPPRTGPPRLLVSLPTKEEESLL
Sbjct: 121 RSCLPPTCFTTPSTAAPDPVLPPLPAKRHLAELSVPPVPPRTGPPRLLVSLPTKEEESLL 180
Query: 181 PSLSSPPQPQSEEPLSTLPQGPPQPPSPPPCPPEIPPKPVRLFPEFDDSDYDEVPEEGPG 240
PSLSSPPQPQSEEPLSTLPQGPPQPPSPPPCPPEIPPKPVRLFPEFDDSDYDEVPEEGPG
Sbjct: 181 PSLSSPPQPQSEEPLSTLPQGPPQPPSPPPCPPEIPPKPVRLFPEFDDSDYDEVPEEGPG 240
Query: 241 APARVMTKKEEPPPSRVPRAVRVASLLSEGEELSGDDQGDEEEDDHAYEGVPNGGWHTSS 300
APARVMTKKEEPPPSRVPRAVRVASLLSEGEELSGDDQGDEEEDDHAYEGVPNGGWHTSS
Sbjct: 241 APARVMTKKEEPPPSRVPRAVRVASLLSEGEELSGDDQGDEEEDDHAYEGVPNGGWHTSS 300
Query: 301 LSLSLPSTIAAPHPMDGPPGGSTPVTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYF 360
LSLSLPSTIAAPHPMDGPPGGSTPVTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYF
Sbjct: 301 LSLSLPSTIAAPHPMDGPPGGSTPVTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYF 360
Query: 361 DSNKDAYSKRFISVACISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQALQQAMAE 420
DSNKDAYSKRFISVACISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQALQQAMAE
Sbjct: 361 DSNKDAYSKRFISVACISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQALQQAMAE 420
Query: 421 QRARARLSSAYLLGVPGSEQPDRAGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGI 480
QRARARLSSAYLLGVPGSEQPDRAGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGI
Sbjct: 421 QRARARLSSAYLLGVPGSEQPDRAGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGI 480
Query: 481 TFIDMSVGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAER 540
TFIDMSVGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAER
Sbjct: 481 TFIDMSVGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAER 540
Query: 541 IWAAAPNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTET 600
IWAAAPNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTET
Sbjct: 541 IWAAAPNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTET 600
Query: 601 LIELFLQLGNGAGNRFWAANVPPSEALQPSSSPSTRRCHLEAKYREGKYRRYHPLFGNQE 660
LIELFLQLGNGAGNRFWAANVPPSEALQPSSSPSTRRCHLEAKYREGKYRRYHPLFGNQE
Sbjct: 601 LIELFLQLGNGAGNRFWAANVPPSEALQPSSSPSTRRCHLEAKYREGKYRRYHPLFGNQE 660
Query: 661 ELDKALCAAVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQMEFLRNNR 720
ELDKALCAAVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQMEFLRNNR
Sbjct: 661 ELDKALCAAVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQMEFLRNNR 720
Query: 721 TTEVPRLDSMKPLEKHYSVVLPTVSHSGFLYKTASAGKLLQDRRAREEFSRRWCVLGDGV 780
TTEVPRLDSMKPLEKHYSVVLPTVSHSGFLYKTASAGKLLQDRRAREEFSRRWCVLGDGV
Sbjct: 721 TTEVPRLDSMKPLEKHYSVVLPTVSHSGFLYKTASAGKLLQDRRAREEFSRRWCVLGDGV 780
Query: 781 LSYFENERAVTPNGEIRASEIVCLAVPPPDTHGFEHTFEVYTEGERLYLFGLESAEQAHE 840
LSYFENERAVTPNGEIRASEIVCLAVPPPDTHGFEHTFEVYTEGERLYLFGLESAEQAHE
Sbjct: 781 LSYFENERAVTPNGEIRASEIVCLAVPPPDTHGFEHTFEVYTEGERLYLFGLESAEQAHE 840
Query: 841 WVKCIAKAFVPPLAEDLLARDFERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPEGPC 900
WVKCIAKAFVPPLAEDLLARDFERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPEGPC
Sbjct: 841 WVKCIAKAFVPPLAEDLLARDFERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPEGPC 900
Query: 901 EEPLQLRKLQELSIQGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTL 960
EEPLQLRKLQELSIQGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTL
Sbjct: 901 EEPLQLRKLQELSIQGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTL 960
Query: 961 SEQQLGDSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEG 1020
SEQQLGDSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEG
Sbjct: 961 SEQQLGDSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEG 1020
Query: 1021 EQHVDDVSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRA 1080
EQHVDDVSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRA
Sbjct: 1021 EQHVDDVSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRA 1080
Query: 1081 TVKALISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAGRVVEDLINHYVVVFS 1140
TVKALISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAGRVVEDLINHYVVVFS
Sbjct: 1081 TVKALISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAGRVVEDLINHYVVVFS 1140
Query: 1141 VDEEELRKQREEITAIVKMRVAGTASGTQHAGDFICTVYLEEKKAETEQHIKVPASMTAE 1200
VDEEELRKQREEITAIVKMRVAGTASGTQHAGDFICTVYLEEKKAETEQHIKVPASMTAE
Sbjct: 1141 VDEEELRKQREEITAIVKMRVAGTASGTQHAGDFICTVYLEEKKAETEQHIKVPASMTAE 1200
Query: 1201 ELTLEILDRRNVGIREKDYWTCFEVNEREEAERPLHFAEKVLPILHGLGTDSHLVVKKHQ 1260
ELTLEILDRRNVGIREKDYWTCFEVNEREEAERPLHFAEKVLPILHGLGTDSHLVVKKHQ
Sbjct: 1201 ELTLEILDRRNVGIREKDYWTCFEVNEREEAERPLHFAEKVLPILHGLGTDSHLVVKKHQ 1260
Query: 1261 AMEAMLLYLASRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVRSQ 1320
AMEAMLLYLASRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVRSQ
Sbjct: 1261 AMEAMLLYLASRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVRSQ 1320
Query: 1321 RPWSGAPETSHRPEKEWPIKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDT 1380
RPWSGAPETSHRPEKEWPIKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDT
Sbjct: 1321 RPWSGAPETSHRPEKEWPIKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDT 1380
Query: 1381 QMELREWFATFLFVQHDGLVWPSEPSRVSRAVPEVRLGSVSLIPLRGSENEMRRSVAAFT 1440
QMELREWFATFLFVQHDGLVWPSEPSRVSRAVPEVRLGSVSLIPLRGSENEMRRSVAAFT
Sbjct: 1381 QMELREWFATFLFVQHDGLVWPSEPSRVSRAVPEVRLGSVSLIPLRGSENEMRRSVAAFT 1440
Query: 1441 ADPLSLLRNV 1450
ADPLSLLRNV
Sbjct: 1441 ADPLSLLRNV 1450
>gi|206597513 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain
1 isoform a [Homo sapiens]
Length = 1205
Score = 2437 bits (6316), Expect = 0.0
Identities = 1205/1205 (100%), Positives = 1205/1205 (100%)
Query: 246 MTKKEEPPPSRVPRAVRVASLLSEGEELSGDDQGDEEEDDHAYEGVPNGGWHTSSLSLSL 305
MTKKEEPPPSRVPRAVRVASLLSEGEELSGDDQGDEEEDDHAYEGVPNGGWHTSSLSLSL
Sbjct: 1 MTKKEEPPPSRVPRAVRVASLLSEGEELSGDDQGDEEEDDHAYEGVPNGGWHTSSLSLSL 60
Query: 306 PSTIAAPHPMDGPPGGSTPVTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKD 365
PSTIAAPHPMDGPPGGSTPVTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKD
Sbjct: 61 PSTIAAPHPMDGPPGGSTPVTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKD 120
Query: 366 AYSKRFISVACISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARA 425
AYSKRFISVACISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARA
Sbjct: 121 AYSKRFISVACISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARA 180
Query: 426 RLSSAYLLGVPGSEQPDRAGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDM 485
RLSSAYLLGVPGSEQPDRAGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDM
Sbjct: 181 RLSSAYLLGVPGSEQPDRAGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDM 240
Query: 486 SVGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAA 545
SVGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAA
Sbjct: 241 SVGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAA 300
Query: 546 PNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIELF 605
PNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIELF
Sbjct: 301 PNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIELF 360
Query: 606 LQLGNGAGNRFWAANVPPSEALQPSSSPSTRRCHLEAKYREGKYRRYHPLFGNQEELDKA 665
LQLGNGAGNRFWAANVPPSEALQPSSSPSTRRCHLEAKYREGKYRRYHPLFGNQEELDKA
Sbjct: 361 LQLGNGAGNRFWAANVPPSEALQPSSSPSTRRCHLEAKYREGKYRRYHPLFGNQEELDKA 420
Query: 666 LCAAVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQMEFLRNNRTTEVP 725
LCAAVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQMEFLRNNRTTEVP
Sbjct: 421 LCAAVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQMEFLRNNRTTEVP 480
Query: 726 RLDSMKPLEKHYSVVLPTVSHSGFLYKTASAGKLLQDRRAREEFSRRWCVLGDGVLSYFE 785
RLDSMKPLEKHYSVVLPTVSHSGFLYKTASAGKLLQDRRAREEFSRRWCVLGDGVLSYFE
Sbjct: 481 RLDSMKPLEKHYSVVLPTVSHSGFLYKTASAGKLLQDRRAREEFSRRWCVLGDGVLSYFE 540
Query: 786 NERAVTPNGEIRASEIVCLAVPPPDTHGFEHTFEVYTEGERLYLFGLESAEQAHEWVKCI 845
NERAVTPNGEIRASEIVCLAVPPPDTHGFEHTFEVYTEGERLYLFGLESAEQAHEWVKCI
Sbjct: 541 NERAVTPNGEIRASEIVCLAVPPPDTHGFEHTFEVYTEGERLYLFGLESAEQAHEWVKCI 600
Query: 846 AKAFVPPLAEDLLARDFERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPEGPCEEPLQ 905
AKAFVPPLAEDLLARDFERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPEGPCEEPLQ
Sbjct: 601 AKAFVPPLAEDLLARDFERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPEGPCEEPLQ 660
Query: 906 LRKLQELSIQGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLSEQQL 965
LRKLQELSIQGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLSEQQL
Sbjct: 661 LRKLQELSIQGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLSEQQL 720
Query: 966 GDSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVD 1025
GDSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVD
Sbjct: 721 GDSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVD 780
Query: 1026 DVSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKAL 1085
DVSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKAL
Sbjct: 781 DVSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKAL 840
Query: 1086 ISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAGRVVEDLINHYVVVFSVDEEE 1145
ISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAGRVVEDLINHYVVVFSVDEEE
Sbjct: 841 ISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAGRVVEDLINHYVVVFSVDEEE 900
Query: 1146 LRKQREEITAIVKMRVAGTASGTQHAGDFICTVYLEEKKAETEQHIKVPASMTAEELTLE 1205
LRKQREEITAIVKMRVAGTASGTQHAGDFICTVYLEEKKAETEQHIKVPASMTAEELTLE
Sbjct: 901 LRKQREEITAIVKMRVAGTASGTQHAGDFICTVYLEEKKAETEQHIKVPASMTAEELTLE 960
Query: 1206 ILDRRNVGIREKDYWTCFEVNEREEAERPLHFAEKVLPILHGLGTDSHLVVKKHQAMEAM 1265
ILDRRNVGIREKDYWTCFEVNEREEAERPLHFAEKVLPILHGLGTDSHLVVKKHQAMEAM
Sbjct: 961 ILDRRNVGIREKDYWTCFEVNEREEAERPLHFAEKVLPILHGLGTDSHLVVKKHQAMEAM 1020
Query: 1266 LLYLASRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVRSQRPWSG 1325
LLYLASRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVRSQRPWSG
Sbjct: 1021 LLYLASRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVRSQRPWSG 1080
Query: 1326 APETSHRPEKEWPIKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDTQMELR 1385
APETSHRPEKEWPIKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDTQMELR
Sbjct: 1081 APETSHRPEKEWPIKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDTQMELR 1140
Query: 1386 EWFATFLFVQHDGLVWPSEPSRVSRAVPEVRLGSVSLIPLRGSENEMRRSVAAFTADPLS 1445
EWFATFLFVQHDGLVWPSEPSRVSRAVPEVRLGSVSLIPLRGSENEMRRSVAAFTADPLS
Sbjct: 1141 EWFATFLFVQHDGLVWPSEPSRVSRAVPEVRLGSVSLIPLRGSENEMRRSVAAFTADPLS 1200
Query: 1446 LLRNV 1450
LLRNV
Sbjct: 1201 LLRNV 1205
>gi|206597515 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain
1 isoform d [Homo sapiens]
Length = 1133
Score = 1572 bits (4071), Expect = 0.0
Identities = 819/1022 (80%), Positives = 863/1022 (84%), Gaps = 78/1022 (7%)
Query: 487 VGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAAP 546
+ +V + + F++ T R F+F A+S++E+++W++A+Q A+AE + + ++ P
Sbjct: 132 ISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARARLSSAYLLGVP 191
Query: 547 NRFCADCGAPQPDWAS---------------INLCVVICKRCAGEHRGLGA-----GVSK 586
G+ QPD A + V + K H G+G V
Sbjct: 192 -------GSEQPDRAGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDMSVGN 244
Query: 587 VRSL--------------------KMDRKVWTETLIELFLQL--GNGAGNRFWAANVPPS 624
V+ + +++++ W E + + + R WAA P+
Sbjct: 245 VKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAA--APN 302
Query: 625 EALQPSSSP-----STRRCHLEAKYREGKYR-------RYHPLFGNQ----EELDKALCA 668
+P S C + K G++R + L ++ E L +ALCA
Sbjct: 303 RFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIEALCA 362
Query: 669 AVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQMEFLRNNRTTEVPRLD 728
AVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQMEFLRNNRTTEVPRLD
Sbjct: 363 AVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQMEFLRNNRTTEVPRLD 422
Query: 729 SMKPLEKHYSVVLPTVSHSGFLYKTASAGKLLQDRRAREEFSRRWCVLGDGVLSYFENER 788
SMKPLEKHYSVVLPTVSHSGFLYKTASAGKLLQDRRAREEFSRRWCVLGDGVLSYFENER
Sbjct: 423 SMKPLEKHYSVVLPTVSHSGFLYKTASAGKLLQDRRAREEFSRRWCVLGDGVLSYFENER 482
Query: 789 AVTPNGEIRASEIVCLAVPPPDTHGFEHTFEVYTEGERLYLFGLESAEQAHEWVKCIAKA 848
AVTPNGEIRASEIVCLAVPPPDTHGFEHTFEVYTEGERLYLFGLESAEQAHEWVKCIAKA
Sbjct: 483 AVTPNGEIRASEIVCLAVPPPDTHGFEHTFEVYTEGERLYLFGLESAEQAHEWVKCIAKA 542
Query: 849 FVPPLAEDLLARDFERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPEGPCEEPLQLRK 908
FVPPLAEDLLARDFERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPEGPCEEPLQLRK
Sbjct: 543 FVPPLAEDLLARDFERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPEGPCEEPLQLRK 602
Query: 909 LQELSIQGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLSEQQLGDS 968
LQELSIQGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLSEQQLGDS
Sbjct: 603 LQELSIQGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLSEQQLGDS 662
Query: 969 DIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDVS 1028
DIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDVS
Sbjct: 663 DIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDVS 722
Query: 1029 SALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISH 1088
SALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISH
Sbjct: 723 SALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISH 782
Query: 1089 LYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAGRVVEDLINHYVVVFSVDEEELRK 1148
LYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAGRVVEDLINHYVVVFSVDEEELRK
Sbjct: 783 LYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAGRVVEDLINHYVVVFSVDEEELRK 842
Query: 1149 QREEITAIVKMRVAGTASGTQHAGDFICTVYLEEKKAETEQHIKVPASMTAEELTLEILD 1208
QREEITAIVKMRVAGTASGTQHAGDFICTVYLEEKKAETEQHIKVPASMTAEELTLEILD
Sbjct: 843 QREEITAIVKMRVAGTASGTQHAGDFICTVYLEEKKAETEQHIKVPASMTAEELTLEILD 902
Query: 1209 RRNVGIREKDYWTCFEVNEREEAERPLHFAEKVLPILHGLGTDSHLVVKKHQAMEAMLLY 1268
RRNVGIREKDYWTCFEVNEREEAERPLHFAEKVLPILHGLGTDSHLVVKKHQAMEAMLLY
Sbjct: 903 RRNVGIREKDYWTCFEVNEREEAERPLHFAEKVLPILHGLGTDSHLVVKKHQAMEAMLLY 962
Query: 1269 LASRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVRSQRPWSGAPE 1328
LASRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVR
Sbjct: 963 LASRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVR---------- 1012
Query: 1329 TSHRPEKEWPIKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDTQMELREWF 1388
SHRPEKEWPIKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDTQMELREWF
Sbjct: 1013 -SHRPEKEWPIKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDTQMELREWF 1071
Query: 1389 ATFLFVQHDGLVWPSEPSRVSRAVPEVRLGSVSLIPLRGSENEMRRSVAAFTADPLSLLR 1448
ATFLFVQHDGLVWPSEPSRVSRAVPEVRLGSVSLIPLRGSENEMRRSVAAFTADPLSLLR
Sbjct: 1072 ATFLFVQHDGLVWPSEPSRVSRAVPEVRLGSVSLIPLRGSENEMRRSVAAFTADPLSLLR 1131
Query: 1449 NV 1450
NV
Sbjct: 1132 NV 1133
Score = 728 bits (1880), Expect = 0.0
Identities = 358/358 (100%), Positives = 358/358 (100%)
Query: 246 MTKKEEPPPSRVPRAVRVASLLSEGEELSGDDQGDEEEDDHAYEGVPNGGWHTSSLSLSL 305
MTKKEEPPPSRVPRAVRVASLLSEGEELSGDDQGDEEEDDHAYEGVPNGGWHTSSLSLSL
Sbjct: 1 MTKKEEPPPSRVPRAVRVASLLSEGEELSGDDQGDEEEDDHAYEGVPNGGWHTSSLSLSL 60
Query: 306 PSTIAAPHPMDGPPGGSTPVTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKD 365
PSTIAAPHPMDGPPGGSTPVTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKD
Sbjct: 61 PSTIAAPHPMDGPPGGSTPVTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKD 120
Query: 366 AYSKRFISVACISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARA 425
AYSKRFISVACISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARA
Sbjct: 121 AYSKRFISVACISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARA 180
Query: 426 RLSSAYLLGVPGSEQPDRAGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDM 485
RLSSAYLLGVPGSEQPDRAGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDM
Sbjct: 181 RLSSAYLLGVPGSEQPDRAGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDM 240
Query: 486 SVGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAA 545
SVGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAA
Sbjct: 241 SVGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAA 300
Query: 546 PNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIE 603
PNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIE
Sbjct: 301 PNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIE 358
>gi|21264592 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
[Homo sapiens]
Length = 1704
Score = 847 bits (2188), Expect = 0.0
Identities = 469/1140 (41%), Positives = 682/1140 (59%), Gaps = 63/1140 (5%)
Query: 329 IKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKDAYSKRFISVACISHVAAIGDQKF 388
+K+GWLDK PQG ++QKRWV+ D + Y+++ K+ YSK I ++ IS V GD KF
Sbjct: 484 VKSGWLDKLSPQGKRMFQKRWVKFDGLSISYYNNEKEMYSKGIIPLSAISTVRVQGDNKF 543
Query: 389 EVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARARLSSAYLLGVPGSEQPDRAGSLE 448
EV+T RTF FR E + ER +W+ L A+ Q ++ + P++ G LE
Sbjct: 544 EVVTTQRTFVFRVEKEEERNDWISILLNALKSQSLTSQSQAVVT--------PEKCGYLE 595
Query: 449 LRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDMSVGNVKEVDR---RSFDLTTPYR 505
LRG+K K++ + G+ V L KN +++ G+GIT I M+V NVK+VDR +SF++ TPYR
Sbjct: 596 LRGYKAKIFTVLSGNSVWLCKNEQDFKSGLGITIIPMNVANVKQVDRTVKQSFEIITPYR 655
Query: 506 IFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAAPNRFCADCGAPQPDWASINL 565
FSF+A++E EK+ W+EA+Q +IAE LS EVAE+IW NR CADC AP PDWASINL
Sbjct: 656 SFSFTAETEKEKQDWIEAVQQSIAETLSDYEVAEKIWFNESNRSCADCKAPDPDWASINL 715
Query: 566 CVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIELFLQLGNGAGNRFWAANVPPSE 625
CVVICK+CAG+HR LG SKVRSLKMD +W+ LIELF+ +GN N FWA N+ E
Sbjct: 716 CVVICKKCAGQHRSLGPKDSKVRSLKMDASIWSNELIELFIVIGNKRANDFWAGNLQKDE 775
Query: 626 ALQPSSSPSTRRCHLEAKYREGKYRRYHPLFGNQEELDKALCAAVTTTDLAETQALLGCG 685
L S R+ + KY+EGK+R+ +EEL+KALCAAV D+ ET ALL G
Sbjct: 776 ELHMDSPVEKRKNFITQKYKEGKFRKTLLASLTKEELNKALCAAVVKPDVLETMALLFSG 835
Query: 686 AGINCFSGDPEAPTPLALAEQAGQTLQMEFLRNNRTTEVPRLDSMKPLEKHYSVVLPTVS 745
A + C +GDP TP LA++AGQ+LQMEFL +N+ ++ P+ D H VL S
Sbjct: 836 ADVMCATGDPVHSTPYLLAKKAGQSLQMEFLYHNKFSDFPQHDI------HSEGVLSQES 889
Query: 746 HSG-----FLYKTAS-AGKLLQDRRAREEFSRRWCVLGDGVLSYFENERAVTPNGEIRAS 799
FLY+ S A KL +++ EE +++WCVL G LSY+EN+++ TPNG I +
Sbjct: 890 SQSTFLCDFLYQAPSAASKLSSEKKLLEETNKKWCVLEGGFLSYYENDKSTTPNGTININ 949
Query: 800 EIVCLAVPPPDTH---GFEHTFEVYTEGERLYLFGLESAEQAHEWVKCIAKAFVPPLAED 856
E++CLA+ D + G FE+Y ER++LFG E+++ +W + IAK FVP AE+
Sbjct: 950 EVICLAIHKEDFYLNTGPIFIFEIYLPSERVFLFGAETSQAQRKWTEAIAKHFVPLFAEN 1009
Query: 857 LLARDFERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPEGPCE-EPLQLRKLQELSI- 914
L D++ +G+L YK +L + ++GWF++ S L + + + LR+LQEL+I
Sbjct: 1010 LTEADYDLIGQLFYKDCHALDQWRKGWFAMDKSSLHFCLQMQEVQGDRMHLRRLQELTIS 1069
Query: 915 ---QGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLSEQQLGDSDIP 971
Q + VL+LVE+ RTLYI G +LDF W AI+KAA + G+ L +QQL +D+P
Sbjct: 1070 TMVQNGEKLDVLLLVEKGRTLYIHGHTKLDFTVWHTAIEKAAGTDGNALQDQQLSKNDVP 1129
Query: 972 VIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDVSSAL 1031
+IV C+ ++TQ GL + IY+K G LLES ++DARS L+ G+ ++DV++ L
Sbjct: 1130 IIVNSCIAFVTQYGLGCKYIYQKNGDPLHISELLESFKKDARSFKLRAGKHQLEDVTAVL 1189
Query: 1032 KRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISHLYC 1091
K FL D+ D L T+ W+ A + +D++E++ +Y + LP VNRAT+ A+I HLY
Sbjct: 1190 KSFLSDIDDALLTKELYPYWISALDTQDDKERIKKYGAFIRSLPGVNRATLAAIIEHLYR 1249
Query: 1092 VQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAGRVVEDLINHYVVVFSVDEEELRKQRE 1151
VQ S+ N MN HNLA+VF LFQT GQ + V+EDLIN+YV +F V E+++++
Sbjct: 1250 VQKCSEINHMNAHNLALVFSSCLFQTKGQTSEEVNVIEDLINNYVEIFEVKEDQVKQMDI 1309
Query: 1152 EITAIVKMRVAGTASGTQHAGDFICTVYLEEKKAETEQHIKVPASMTAEELTLEILDRRN 1211
E + I K + + AGD + VY+E K+ + I++ M AEELT +IL +N
Sbjct: 1310 ENSFITKWK----DTQVSQAGDLLIEVYVERKEPDCSIIIRISPVMEAEELTNDILAIKN 1365
Query: 1212 VGIREKDYWTCFEVNEREEAERPLHFAEKVLPILHGLGT-----DSHLVVKKHQAMEAML 1266
+ + D W FEV E EE ERPLH+ E VL + + ++LVVK+ + +
Sbjct: 1366 IIPTKGDIWATFEVIENEELERPLHYKENVLEQVLRWSSLAEPGSAYLVVKRFLTADTIK 1425
Query: 1267 -LYLASRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVRSQRPWSG 1325
S +G K G++K +E+ S + L F DRYF+L L LYK+V+S
Sbjct: 1426 HCSDRSTLGSIKEGILKIKEEPSKI---LSGNKFQDRYFVLRDGFLFLYKDVKSS----- 1477
Query: 1326 APETSHRPEKEWPIKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDTQMELR 1385
+ +K + + S+K Y GVKKK++PPT WG T EK W+LCCD+
Sbjct: 1478 ------KHDKMFSLSSMKFYRGVKKKMKPPTSWGLTAY-----SEKHHWHLCCDSSRTQT 1526
Query: 1386 EWFATFLFVQHDGLVWPSEPSRVSRAVPE-VRLGSVSLIPLR--GSENEMRRSVAAFTAD 1442
EW + QH+ +WP R++ + ++G + LIP++ G+ R+++ + A+
Sbjct: 1527 EWMTSIFIAQHEYDIWPPAGKERKRSITKNPKIGGLPLIPIQHEGNATLARKNIESARAE 1586
Score = 44.3 bits (103), Expect = 9e-04
Identities = 20/64 (31%), Positives = 36/64 (56%)
Query: 1 MAEAGDAALSVAEWLRALHLEQYTGLFEQHGLVWATECQGLSDTRLMDMGMLLPGHRRRI 60
M+ + + + ++L +++LEQY F + G +C ++D+ L +G+ GHRRRI
Sbjct: 1 MSSVSEVNVDIKDFLMSINLEQYLLHFHESGFTTVKDCAAINDSLLQKIGISPTGHRRRI 60
Query: 61 LAGL 64
L L
Sbjct: 61 LKQL 64
>gi|21264337 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
[Homo sapiens]
Length = 1544
Score = 763 bits (1971), Expect = 0.0
Identities = 510/1468 (34%), Positives = 733/1468 (49%), Gaps = 161/1468 (10%)
Query: 9 LSVAEWLRALHLEQYTGLFEQHGLVWATECQGLSDTRLMDMGMLLPGHRRRILAGLLRAH 68
L +A WL +HLEQY F +HGL A +GL L +G+ GHR+RIL LL+
Sbjct: 7 LDIAVWLATVHLEQYADTFRRHGLATAGAARGLGHEELKQLGISATGHRKRILR-LLQTG 65
Query: 69 T---------------SPAPAPRPTP-RPVPMKRHIFRSPPVPATPPEPLPTTTEDEGLP 112
T SP+PAP+ P +PVP R +F PAT P GL
Sbjct: 66 TEEGSLDPKSDSAMEPSPSPAPQAQPPKPVPKPRTVFGGLSGPATTQRP--------GL- 116
Query: 113 AAPPIPPRRSCLPPTCFTTPSTAAPDPVLPPLPAKRHLAELSVPPVPPRTGPPRLLVSLP 172
+P+ P P P+ R PP+P + ++
Sbjct: 117 ------------------SPALGGPGVSRSPEPSPRP------PPLPTSSSEQSSALNTV 152
Query: 173 TKEEESLLPSLSSPPQPQSEEPLSTLPQGPPQPPSPPPCPPEIPPKPVRLFPEFDDSDYD 232
S+ L S + Q+ + + P P P P + Y
Sbjct: 153 EMMPNSIYFGLDSRGRAQAAQD-----KAPDSSQISAPTPALRPTTGTVHIMDPGCLYYG 207
Query: 233 EVPEEGPGAPARVMTKKEEPPPSRVPRAVRVASLLSEGEELSGDDQGDEEEDDHAYEGVP 292
P PGAP R R R LS D E+ +A +P
Sbjct: 208 VQPVGTPGAPDR--------------RESRGVCQGRAEHRLSRQDLEAREDAGYASLELP 253
Query: 293 NGGWHTSSLSLSLPSTIAAPHPMDGPPGGSTPVTPVIKAGWLDKNPPQGSYIYQKRWVRL 352
S + ++ P + +TP++ +GWLDK PQG+Y++Q+R+V+
Sbjct: 254 GDSTLLSPTLETEETSDDLISPYASFSFTADRLTPLL-SGWLDKLSPQGNYVFQRRFVQF 312
Query: 353 DTDHLRYFDSNKDAYSKRFISVACISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQ 412
+ L YF S+KD + K I + I + D KF+VIT R F FR ES+ +R W
Sbjct: 313 NGRSLMYFGSDKDPFPKGVIPLTAIEMTRSSKDNKFQVITGQRVFVFRTESEAQRDMWCS 372
Query: 413 ALQQAMAEQRARARLSSAYLLGVPGSEQPDR---AGSLELRGFKNKLYVAVVGDKVQLYK 469
LQ + EQR LLG P QP R G LELRG K K++ A+ ++ LYK
Sbjct: 373 TLQSCLKEQR---------LLGHPRPPQPPRPLRTGMLELRGHKAKVFAALSPGELALYK 423
Query: 470 NLEEYHLGIGITFIDMSVGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIA 529
+ + + LGIGI FI++ +V+E RSFDL TP+R FSF+A+S ++ W A+Q A+
Sbjct: 424 SEQAFSLGIGICFIELQGCSVRETKSRSFDLLTPHRCFSFTAESGGARQSWAAALQEAVT 483
Query: 530 EALSTSEVAERIWAAAPNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRS 589
E LS EVAE+IW+ NR CADCG+ +PDWA++NL VVICK+CAG+HR LG+G+SKV+S
Sbjct: 484 ETLSDYEVAEKIWSNRANRQCADCGSSRPDWAAVNLGVVICKQCAGQHRALGSGISKVQS 543
Query: 590 LKMDRKVWTETLIELFLQLGNGAGNRFWAANVPPSEALQPSSSPSTRRCHLEAKYREGKY 649
LK+D VW+ +++LF+ LGN NRFWA +PP E L P ++P R + KYR G +
Sbjct: 544 LKLDTSVWSNEIVQLFIVLGNDRANRFWAGTLPPGEGLHPDATPGPRGEFISRKYRLGLF 603
Query: 650 RRYHPLFGNQEELDKALCAAVTTTDLAETQALLGCGAGINCFSGD----PEAPTPLALAE 705
R+ HP + + +L +ALCAAV +L + L C + F G+ P AP
Sbjct: 604 RKPHPQYPDHSQLLQALCAAVARPNLLKNMTQLLC---VEAFEGEEPWFPPAP------- 653
Query: 706 QAGQTLQMEFLRNNRTTEVPRLDSMKPLEKHYSVVLPTVSHSGFLYKTASAGKL--LQDR 763
P L P Y+ V+ ++SGFLY + + K R
Sbjct: 654 ---------------DGSCPGLLPSDPSPGVYNEVVVRATYSGFLYCSPVSNKAGPSPPR 698
Query: 764 RAREEFSRRWCVLGDGVLSYFENERAVTPNGEIRASEIVCLAVPPPDT---HGFEHTFEV 820
R R+ R WCVLG L F +E + P I+ +IVCL V PP T F +FE+
Sbjct: 699 RGRDAPPRLWCVLG-AALEMFASENSPEPLSLIQPQDIVCLGVSPPPTDPGDRFPFSFEL 757
Query: 821 YTEGERLYLFGLESAEQAHEWVKCIAKAFVPPLAEDLLARDFERLGRLPYKAGLSLQRAQ 880
G R+ FG + A+ W + K F P LL RLGRL ++ A
Sbjct: 758 ILAGGRIQHFGTDGADSLEAWTSAVGKWFSPLSCHQLLGPGLLRLGRLWLRSPSHTAPAP 817
Query: 881 EGWFS----LSGSELRAVFPEGP----CEEPLQLRKLQELSIQGDSE----NQVLVLVER 928
W S L G L GP E+ + LR+LQE+S+ ++ + LVLVE
Sbjct: 818 GLWLSGFGLLRGDHLFLCSAPGPGPPAPEDMVHLRRLQEISVVSAADTPDKKEHLVLVET 877
Query: 929 RRTLYIQGERRLDFMGWLGAIQKAAASMGDTLSEQQLGDSDIPVIVYRCVDYITQCGLTS 988
RTLY+QGE RLDF W AI AA G L EQQ+ DIP+IV C+ ++TQ GL
Sbjct: 878 GRTLYLQGEGRLDFTAWNAAIGGAAGGGGTGLQEQQMSRGDIPIIVDACISFVTQHGLRL 937
Query: 989 EGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDVSSALKRFLRDLPDGLFTRAQR 1048
EG+YRK G +++ RLL R+DARSV L+ GE V+DV+ LKRF R+L D + +
Sbjct: 938 EGVYRKGGARARSLRLLAEFRRDARSVKLRPGEHFVEDVTDTLKRFFRELDDPVTSARLL 997
Query: 1049 LTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISHLYCVQCFSDTNQMNVHNLAI 1108
W EA+E+ + +++ +Y++++ LP VNR T+ LI HLY VQ + NQM NLA+
Sbjct: 998 PRWREAAELPQKNQRLEKYKDVIGCLPRVNRRTLATLIGHLYRVQKCAALNQMCTRNLAL 1057
Query: 1109 VFGPTLFQTDGQDYKAGRVVEDLINHYVVVFSVDEEELRKQREEITAIVKMRVAGTASGT 1168
+F P++FQTDG+ RV+++LI+ Y+ VF +D +++ + E++ I + +
Sbjct: 1058 LFAPSVFQTDGRGEHEVRVLQELIDGYISVFDIDSDQVAQIDLEVSLITTWKDVQLS--- 1114
Query: 1169 QHAGDFICTVYLEEKKAETEQHIKVPASMTAEELTLEILDRRNVGIREKDYWTCFEVNER 1228
AGD I VY+E++ + +KV ++TAEELT ++L+ R D W FE+ E
Sbjct: 1115 -QAGDLIMEVYIEQQLPDNCVTLKVSPTLTAEELTNQVLEMRGTA-AGMDLWVTFEIREH 1172
Query: 1229 EEAERPLHFAEKVLP-----ILHGLGTDSHLVVKKHQAMEAMLLYLASRVGDTKHGMMKF 1283
E ERPLH EKVL + L++KK +A L+ R + G+++
Sbjct: 1173 GELERPLHPKEKVLEQALQWCQLPEPCSASLLLKKVPLAQAGCLFTGIRRESPRVGLLRC 1232
Query: 1284 RED-RSLLGLGLPSGGFHDRYFILNSSCLRLYKEVRSQRPWSGAPETSHRPEKEWPIKSL 1342
RE+ LLG F +R+F+L CL L KE +S +PE+EWP++
Sbjct: 1233 REEPPRLLG-----SRFQERFFLLRGRCLLLLKEKKSS-----------KPEREWPLEGA 1276
Query: 1343 KVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDTQMELREWFATFLFVQHDGLVWP 1402
KVYLG++KKL+PPT WGFT++ EK YL C + E+ +W + L QHD
Sbjct: 1277 KVYLGIRKKLKPPTPWGFTLI-----LEKMHLYLSCTDEDEMWDWTTSILKAQHDDQQPV 1331
Query: 1403 SEPSRVSRAVPEVRLGSVSLIPLRGSEN 1430
S + + G++ L+P+RG ++
Sbjct: 1332 VLRRHSSSDLARQKFGTMPLLPIRGDDS 1359
Score = 35.4 bits (80), Expect = 0.40
Identities = 39/134 (29%), Positives = 50/134 (37%), Gaps = 37/134 (27%)
Query: 104 TTTEDEGLPAAPPIPPRRSCLPPTCFTTPSTAAPDPVLPPLPAKRHLAELSVPPVPPRTG 163
+TT + + P+ ++S P F + S+ PP P PP PP
Sbjct: 1426 STTREWTVKPENPLTSQKSLDQP--FLSKSSTLGQEERPPEP----------PPGPPSKS 1473
Query: 164 PPRLLVSLPTKEEESLLPSLSS-----------------PPQPQSEEPLSTLPQGPPQPP 206
P+ SL EE LL LSS P PQS P + LP P P
Sbjct: 1474 SPQARGSL----EEQLLQELSSLILRKGETTAGLGSPSQPSSPQSPSP-TGLPTQTPGFP 1528
Query: 207 SPPPC---PPEIPP 217
+ PPC PP P
Sbjct: 1529 TQPPCTSSPPSSQP 1542
>gi|7661962 centaurin, gamma 1 isoform PIKE-S [Homo sapiens]
Length = 836
Score = 104 bits (260), Expect = 5e-22
Identities = 73/248 (29%), Positives = 113/248 (45%), Gaps = 21/248 (8%)
Query: 486 SVGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVA------- 538
S G +E + +++ + + F A S E++ W++A++ I +L E +
Sbjct: 511 SAGQAEEENFEFLIVSSTGQTWHFEAASFEERDAWVQAIESQILASLQCCESSKVKLRTD 570
Query: 539 --------ERIWAAAPNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSL 590
+ I A N C DCGAP P WAS+NL +IC C+G HR LG +S+VRSL
Sbjct: 571 SQSEAVAIQAIRNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSL 630
Query: 591 KMDRKVWTETLIELFLQLGNGAGNRFWAANVPPSEALQPSSSPSTRRCHLEAKYREGKYR 650
+D W L + +GN NR W ++ SS R + AKY + +
Sbjct: 631 DLDD--WPRELTLVLTAIGNDTANRVWESDTRGRAKPSRDSSREERESWIRAKYEQLLF- 687
Query: 651 RYHPLFGNQEELDKALCAAVTTTDLAETQALLGCG--AGINCFSGDPEAPTPLALAEQAG 708
PL ++E L + L AAV D+A LL ++ DP+ +PL LA +
Sbjct: 688 -LAPLSTSEEPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELA 746
Query: 709 QTLQMEFL 716
+ + L
Sbjct: 747 HVVITQLL 754
Score = 32.3 bits (72), Expect = 3.4
Identities = 32/147 (21%), Positives = 51/147 (34%), Gaps = 12/147 (8%)
Query: 160 PRTGPPRLLVSL-PTKEEESLLPSLSSPPQPQSEEPLSTLPQGPPQPPSPPPCPPEIPP- 217
P PPR + + P+ L+ +S+ + E + +P P P S P P +
Sbjct: 400 PGKRPPRAISAFGPSASINGLVKDMSTVQMGEGLEATTPMPSPSPSPSSLQPPPDQTSKH 459
Query: 218 --KPVRLFPEFDDSDYDEVPEEGPGAPARVMTKKEEPPPSRVPRAVRVASLLSEGEELSG 275
KP R +D + P EPPPS + + R L + +
Sbjct: 460 LLKPDRNLARALSTDCTPSGDLSP--------LSREPPPSPMVKKQRRKKLTTPSKTEGS 511
Query: 276 DDQGDEEEDDHAYEGVPNGGWHTSSLS 302
Q +EE + WH + S
Sbjct: 512 AGQAEEENFEFLIVSSTGQTWHFEAAS 538
>gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH domains
3 [Homo sapiens]
Length = 834
Score = 103 bits (258), Expect = 9e-22
Identities = 71/242 (29%), Positives = 117/242 (48%), Gaps = 45/242 (18%)
Query: 454 NKLYVAVVGDKVQLYKNLEEYHLGIGITFIDMSVGNVK---EVDRR-SFDLTTPYRIFSF 509
N+ + ++ ++ K L++ + + D+ + +VK +++RR F++ +P +
Sbjct: 287 NRRWFSIQNSQLVYQKKLKD---ALTVVVDDLRLCSVKPCEDIERRFCFEVLSPTKSCML 343
Query: 510 SADSELEKEQWLEAMQGAIAEALSTS---------------------------------- 535
ADSE ++ W++A+Q +IA A S
Sbjct: 344 QADSEKLRQAWVQAVQASIASAYRESPDSCYSERLDRTASPSTSSIDSATDTRERGVKGE 403
Query: 536 EVAERIWAAAPNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRK 595
V +R+ + A N C DCG P P WASINL V++C C+G HR LG SKVRSL +D
Sbjct: 404 SVLQRVQSVAGNSQCGDCGQPDPRWASINLGVLLCIECSGIHRSLGVHCSKVRSLTLDS- 462
Query: 596 VWTETLIELFLQLGNGAGNRFWAANVPPSEALQP--SSSPSTRRCHLEAKYREGKYRRYH 653
W L++L +LGN A N+ + A + + +P SSS + ++ KY E K+ R
Sbjct: 463 -WEPELLKLMCELGNSAVNQIYEAQCEGAGSRKPTASSSRQDKEAWIKDKYVEKKFLRKA 521
Query: 654 PL 655
P+
Sbjct: 522 PM 523
Score = 35.8 bits (81), Expect = 0.31
Identities = 34/135 (25%), Positives = 57/135 (42%), Gaps = 17/135 (12%)
Query: 315 MDGPPGGSTPVTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKDAYSKRFISV 374
+D P G V+ G+L K + +RW + L Y KDA + +
Sbjct: 263 VDAPSG-------VVMEGYLFKRASNAFKTWNRRWFSIQNSQLVYQKKLKDALTVVVDDL 315
Query: 375 ACISHVAAIGDQK---FEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARARLSSAY 431
S ++ FEV++ ++ +A+S+ R+ W+QA+Q ++A R S Y
Sbjct: 316 RLCSVKPCEDIERRFCFEVLSPTKSCMLQADSEKLRQAWVQAVQASIA-SAYRESPDSCY 374
Query: 432 LLGVPGSEQPDRAGS 446
SE+ DR S
Sbjct: 375 ------SERLDRTAS 383
Score = 33.5 bits (75), Expect = 1.5
Identities = 34/107 (31%), Positives = 45/107 (42%), Gaps = 4/107 (3%)
Query: 661 ELDKALCA--AVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQMEFLRN 718
EL L A A DL A L GA +N + E TPL A G + EFL
Sbjct: 665 ELHPGLLAHRAARARDLPALAAALAHGAEVNWADAEDEGKTPLVQAVLGGSLIVCEFLLQ 724
Query: 719 NRTTEVPRLDSMKPLEKHYSVVL-PTVSHSGFLYKTASAGKLLQDRR 764
N +V + DS H++ +L T FL + A L Q++R
Sbjct: 725 N-GADVNQRDSRGRAPLHHATLLGRTGQVCLFLKRGADQHALDQEQR 770
>gi|170650694 centaurin, gamma 1 isoform PIKE-L [Homo sapiens]
Length = 1192
Score = 102 bits (254), Expect = 3e-21
Identities = 70/225 (31%), Positives = 103/225 (45%), Gaps = 21/225 (9%)
Query: 509 FSADSELEKEQWLEAMQGAIAEALSTSEVA---------------ERIWAAAPNRFCADC 553
F A S E++ W++A++ I +L E + + I A N C DC
Sbjct: 890 FEAASFEERDAWVQAIESQILASLQCCESSKVKLRTDSQSEAVAIQAIRNAKGNSICVDC 949
Query: 554 GAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIELFLQLGNGAG 613
GAP P WAS+NL +IC C+G HR LG +S+VRSL +D W L + +GN
Sbjct: 950 GAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDD--WPRELTLVLTAIGNDTA 1007
Query: 614 NRFWAANVPPSEALQPSSSPSTRRCHLEAKYREGKYRRYHPLFGNQEELDKALCAAVTTT 673
NR W ++ SS R + AKY + + PL ++E L + L AAV
Sbjct: 1008 NRVWESDTRGRAKPSRDSSREERESWIRAKYEQLLF--LAPLSTSEEPLGRQLWAAVQAQ 1065
Query: 674 DLAETQALLGCG--AGINCFSGDPEAPTPLALAEQAGQTLQMEFL 716
D+A LL ++ DP+ +PL LA + + + L
Sbjct: 1066 DVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLL 1110
Score = 36.2 bits (82), Expect = 0.24
Identities = 31/98 (31%), Positives = 43/98 (43%), Gaps = 18/98 (18%)
Query: 131 TPSTAAPDPVLPPLPAKRHLAELSVPPVPPRTG---PPRLLVSLPTKEEESLLPSLS-SP 186
+P+ A+P + P P +R L+ +VPP PP +G P PT LL S S
Sbjct: 94 SPAPASPARPVSPAPGRR-LSLWAVPPGPPLSGGLSPDPKPGGAPTSSRRPLLSSPSWGG 152
Query: 187 PQPQSEE----PLSTLPQG---------PPQPPSPPPC 211
P+P+ P S+ P P PP+P PC
Sbjct: 153 PEPEGRAGGGIPGSSSPHPGTGSRRLKVAPPPPAPKPC 190
>gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]
Length = 1397
Score = 99.8 bits (247), Expect = 2e-20
Identities = 64/185 (34%), Positives = 98/185 (52%), Gaps = 9/185 (4%)
Query: 970 IPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGE-QHVDDVS 1028
+P+IV C + GL S GIYR G + L E L + ++L++ Q ++ +S
Sbjct: 825 VPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRGPGDINLQDERWQDLNVIS 884
Query: 1029 SALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISH 1088
S LK F R LP+ LFT + ++EA+ IED E++ R+L+ LP T+K L+ H
Sbjct: 885 SLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARERMRTLRKLIRDLPGHYYETLKFLVGH 944
Query: 1089 LYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDY--------KAGRVVEDLINHYVVVFS 1140
L + S+ N+M NLA+VFGPTL +T + ++VE LI H FS
Sbjct: 945 LKTIADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMPDRYKIVETLIQHSDWFFS 1004
Query: 1141 VDEEE 1145
+E++
Sbjct: 1005 DEEDK 1009
Score = 34.3 bits (77), Expect = 0.90
Identities = 33/115 (28%), Positives = 43/115 (37%), Gaps = 10/115 (8%)
Query: 103 PTTTEDEGLPAAPPIP-PRRSCLPPTCFTTPSTAAPDPVL-----PPLPAKRHLAELSVP 156
P + E +P PPI PR++ PP +T +T P+P P PA L VP
Sbjct: 80 PYSGEARSIPEPPPICYPRKTYAPPARASTRATMVPEPTSALPSDPRSPAAWSDPGLRVP 139
Query: 157 PVPPRTGPPRLLVSLPTKEEESLLPSLSSPPQPQSEEPLSTLPQGPPQPPSPPPC 211
P L + P LSS P+ P + G PPS C
Sbjct: 140 PAARAHLDNSSLGMSQPRPSPGAFPHLSSEPR----TPRAFPEPGSRVPPSRLEC 190
>gi|150417981 glucocorticoid receptor DNA binding factor 1 [Homo
sapiens]
Length = 1499
Score = 99.0 bits (245), Expect = 3e-20
Identities = 55/152 (36%), Positives = 84/152 (55%), Gaps = 1/152 (0%)
Query: 967 DSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDD 1026
+ IP+ + RC++YI GL++EGIYR G S+ + L QD ++ L E + V+
Sbjct: 1258 EKPIPIFIERCIEYIEATGLSTEGIYRVSGNKSEMESLQRQFDQD-HNLDLAEKDFTVNT 1316
Query: 1027 VSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALI 1086
V+ A+K F +LPD L ++ +EA +I D E+K+ +E+L + P N K +I
Sbjct: 1317 VAGAMKSFFSELPDPLVPYNMQIDLVEAHKINDREQKLHALKEVLKKFPKENHEVFKYVI 1376
Query: 1087 SHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTD 1118
SHL V + N M NL+I F PTL + D
Sbjct: 1377 SHLNKVSHNNKVNLMTSENLSICFWPTLMRPD 1408
>gi|194272142 myosin IXB isoform 2 [Homo sapiens]
Length = 2022
Score = 97.4 bits (241), Expect = 9e-20
Identities = 57/196 (29%), Positives = 112/196 (57%), Gaps = 5/196 (2%)
Query: 968 SDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDV 1027
+ +P+++ + ++++ GL +EG+YRK G ++T+ L ++L+ D +V L+ H +
Sbjct: 1710 ASVPIVLEKLLEHVEMHGLYTEGLYRKSGAANRTRELRQALQTDPAAVKLENFPIHA--I 1767
Query: 1028 SSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALIS 1087
+ LK++LR+LP+ L T AQ +L A E+ +++E+++ +L LP N +++ LI
Sbjct: 1768 TGVLKQWLRELPEPLMTFAQYGDFLRAVELPEKQEQLAAIYAVLEHLPEANHNSLERLIF 1827
Query: 1088 HLYCVQCFSDTNQMNVHNLAIVFGPTLFQ-TDGQDYKAGRVVEDLINHYVVVFSVDEEEL 1146
HL V D N+M+ LAI+F P L + D D ++D++ V + +E++
Sbjct: 1828 HLVKVALLEDVNRMSPGALAIIFAPCLLRCPDNSDPLTS--MKDVLKITTCVEMLIKEQM 1885
Query: 1147 RKQREEITAIVKMRVA 1162
RK + ++ I ++ A
Sbjct: 1886 RKYKVKMEEISQLEAA 1901
Score = 31.2 bits (69), Expect = 7.6
Identities = 22/62 (35%), Positives = 26/62 (41%), Gaps = 3/62 (4%)
Query: 160 PRTGPPRLLVSLPTKEEESLLPSLSSPPQPQSEEPLSTLPQGPPQPPSPPPCP--PEIPP 217
P P + V ++E E LPS SP Q E P S PP+P P PE
Sbjct: 1218 PTEQPQAMAVGKVSEETEKTLPS-GSPRPGQLERPTSLALDSRVSPPAPGSAPETPEDKS 1276
Query: 218 KP 219
KP
Sbjct: 1277 KP 1278
>gi|33356170 myosin IXB isoform 1 [Homo sapiens]
Length = 2157
Score = 97.4 bits (241), Expect = 9e-20
Identities = 57/196 (29%), Positives = 112/196 (57%), Gaps = 5/196 (2%)
Query: 968 SDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDV 1027
+ +P+++ + ++++ GL +EG+YRK G ++T+ L ++L+ D +V L+ H +
Sbjct: 1710 ASVPIVLEKLLEHVEMHGLYTEGLYRKSGAANRTRELRQALQTDPAAVKLENFPIHA--I 1767
Query: 1028 SSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALIS 1087
+ LK++LR+LP+ L T AQ +L A E+ +++E+++ +L LP N +++ LI
Sbjct: 1768 TGVLKQWLRELPEPLMTFAQYGDFLRAVELPEKQEQLAAIYAVLEHLPEANHNSLERLIF 1827
Query: 1088 HLYCVQCFSDTNQMNVHNLAIVFGPTLFQ-TDGQDYKAGRVVEDLINHYVVVFSVDEEEL 1146
HL V D N+M+ LAI+F P L + D D ++D++ V + +E++
Sbjct: 1828 HLVKVALLEDVNRMSPGALAIIFAPCLLRCPDNSDPLTS--MKDVLKITTCVEMLIKEQM 1885
Query: 1147 RKQREEITAIVKMRVA 1162
RK + ++ I ++ A
Sbjct: 1886 RKYKVKMEEISQLEAA 1901
Score = 33.9 bits (76), Expect = 1.2
Identities = 37/159 (23%), Positives = 61/159 (38%), Gaps = 21/159 (13%)
Query: 163 GPPRLLVSLPTKEEESLLPSLSSPPQPQSEEPLSTLPQGPPQPPSPPPCPPEIPPKPVRL 222
GPP + P S LP++++PP+ + ++ + P + P P ++PP
Sbjct: 2020 GPPAPALPCPGAPTPSPLPTVAAPPRRRPSSFVTVRVKTPRRTPIMPTANIKLPPG---- 2075
Query: 223 FPEFDDSDYDEVPEEGPGAPARVMTKKEEPPPSRVPRAVRVASLLSEGEELSGDDQGDEE 282
P +P PGA + PP+R P + + ++ G +L +
Sbjct: 2076 LP-------SHLPRWAPGAREAAAPVRRREPPARRPDQIH-SVYITPGADLPVQGALEPL 2127
Query: 283 EDDHAYEGVPNGGWHTSSLSLSLPSTIAAPHPMDGPPGG 321
E+D G P G + S P T P P G G
Sbjct: 2128 EED----GQPPG----AKRRYSDPPTYCLP-PASGQTNG 2157
Score = 31.2 bits (69), Expect = 7.6
Identities = 22/62 (35%), Positives = 26/62 (41%), Gaps = 3/62 (4%)
Query: 160 PRTGPPRLLVSLPTKEEESLLPSLSSPPQPQSEEPLSTLPQGPPQPPSPPPCP--PEIPP 217
P P + V ++E E LPS SP Q E P S PP+P P PE
Sbjct: 1218 PTEQPQAMAVGKVSEETEKTLPS-GSPRPGQLERPTSLALDSRVSPPAPGSAPETPEDKS 1276
Query: 218 KP 219
KP
Sbjct: 1277 KP 1278
>gi|156119615 myosin IXA [Homo sapiens]
Length = 2548
Score = 97.1 bits (240), Expect = 1e-19
Identities = 66/219 (30%), Positives = 114/219 (52%), Gaps = 5/219 (2%)
Query: 952 AAASMGDTLSEQQLGDSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQD 1011
++ G LS D +P++V + ++YI GL +EGIYRK G T+K + L + L D
Sbjct: 2057 SSRQFGVELSRLTSEDRTVPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDTD 2116
Query: 1012 ARSVHLKEGEQHVDDVSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELL 1071
A SV+L + HV ++S K++LRDLP+ L T +L A +++ +E + ++
Sbjct: 2117 AESVNLDDYNIHV--IASVFKQWLRDLPNPLMTFELYEEFLRAMGLQERKETIRGVYSVI 2174
Query: 1072 VRLPPVNRATVKALISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQ-TDGQDYKAGRVVED 1130
+L + T++ LI HL + DTN+M+ + LAIVF P + + D D + V+D
Sbjct: 2175 DQLSRTHLNTLERLIFHLVRIALQEDTNRMSANALAIVFAPCILRCPDTTD--PLQSVQD 2232
Query: 1131 LINHYVVVFSVDEEELRKQREEITAIVKMRVAGTASGTQ 1169
+ V + E++ K + + I + A + T+
Sbjct: 2233 ISKTTTCVELIVVEQMNKYKARLKDISSLEFAENKAKTR 2271
>gi|226693398 Rho GTPase activating protein 27 isoform b [Homo
sapiens]
Length = 521
Score = 95.9 bits (237), Expect = 3e-19
Identities = 104/401 (25%), Positives = 177/401 (44%), Gaps = 57/401 (14%)
Query: 743 TVSHSGFLYKTASAGKLLQDRRAREEFSRRWCVLGDGVLSYFENERAVTPNGEIRASEI- 801
T+ +G L++T +A K R ++ +S W VL GVL++F++ + G + S+
Sbjct: 128 TLDKAGVLHRTKTADK--GKRLRKKHWSASWTVLEGGVLTFFKDSKTSAAGGLRQPSKFS 185
Query: 802 ----------VCLAVPPPDTHGFEHTFEVYTEGERLYLFGLESAEQAHEWVKCIAK---- 847
L+ P D ++ E+ + YL +S W K IA+
Sbjct: 186 TPEYTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGIQE 245
Query: 848 --AFVPPLAEDLLARDF---ERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPE-GPCE 901
A +PP + DF ERLG S Q +E + A P GP
Sbjct: 246 LSAELPPEESESSRVDFGSSERLG--------SWQEKEED------ARPNAAAPALGPVG 291
Query: 902 EPLQLRKLQELSIQGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLS 961
L K++ +++ ++RR TL E+ G A L
Sbjct: 292 LESDLSKVR---------HKLRKFLQRRPTLQSLREKGYIKDQVFGCALAA-------LC 335
Query: 962 EQQLGDSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGE 1021
E++ S +P V +C+ + GL +G+YR G + Q+L + D R + L +G
Sbjct: 336 ERER--SRVPRFVQQCIRAVEARGLDIDGLYRISGNLATIQKLRYKVDHDER-LDLDDGR 392
Query: 1022 -QHVDDVSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRA 1080
+ V ++ ALK F R+LP+ LF + ++ A +++D+ + R+L+ LP N
Sbjct: 393 WEDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHD 452
Query: 1081 TVKALISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQD 1121
T++ L HL V + N+M+V ++AIVFGPTL + + ++
Sbjct: 453 TLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEE 493
>gi|40548322 Rho GTPase activating protein 27 isoform a [Homo sapiens]
Length = 548
Score = 95.9 bits (237), Expect = 3e-19
Identities = 104/401 (25%), Positives = 177/401 (44%), Gaps = 57/401 (14%)
Query: 743 TVSHSGFLYKTASAGKLLQDRRAREEFSRRWCVLGDGVLSYFENERAVTPNGEIRASEI- 801
T+ +G L++T +A K R ++ +S W VL GVL++F++ + G + S+
Sbjct: 155 TLDKAGVLHRTKTADK--GKRLRKKHWSASWTVLEGGVLTFFKDSKTSAAGGLRQPSKFS 212
Query: 802 ----------VCLAVPPPDTHGFEHTFEVYTEGERLYLFGLESAEQAHEWVKCIAK---- 847
L+ P D ++ E+ + YL +S W K IA+
Sbjct: 213 TPEYTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGIQE 272
Query: 848 --AFVPPLAEDLLARDF---ERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPE-GPCE 901
A +PP + DF ERLG S Q +E + A P GP
Sbjct: 273 LSAELPPEESESSRVDFGSSERLG--------SWQEKEED------ARPNAAAPALGPVG 318
Query: 902 EPLQLRKLQELSIQGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLS 961
L K++ +++ ++RR TL E+ G A L
Sbjct: 319 LESDLSKVR---------HKLRKFLQRRPTLQSLREKGYIKDQVFGCALAA-------LC 362
Query: 962 EQQLGDSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGE 1021
E++ S +P V +C+ + GL +G+YR G + Q+L + D R + L +G
Sbjct: 363 ERER--SRVPRFVQQCIRAVEARGLDIDGLYRISGNLATIQKLRYKVDHDER-LDLDDGR 419
Query: 1022 -QHVDDVSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRA 1080
+ V ++ ALK F R+LP+ LF + ++ A +++D+ + R+L+ LP N
Sbjct: 420 WEDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHD 479
Query: 1081 TVKALISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQD 1121
T++ L HL V + N+M+V ++AIVFGPTL + + ++
Sbjct: 480 TLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEE 520
>gi|206597522 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
isoform b [Homo sapiens]
Length = 961
Score = 95.5 bits (236), Expect = 3e-19
Identities = 63/203 (31%), Positives = 100/203 (49%), Gaps = 26/203 (12%)
Query: 494 DRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALS------------------TS 535
+++ FDL + R + F A+ E E + W+ +Q + EAL+ T
Sbjct: 362 EKKCFDLISHDRTYHFQAEDEQECQIWMSVLQNSKEEALNNAFKGDDNTGENNIVQELTK 421
Query: 536 EVAERIWAAAPNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRK 595
E+ + N C DCGAP P W S NL ++ C C+G HR LG S+++SL +D
Sbjct: 422 EIISEVQRMTGNDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSLTLDVL 481
Query: 596 VWTETLIELFLQLGNGAGNRFWAANVPPSEALQPS--SSPSTRRCHLEAKYREGKY-RRY 652
+E L L +GN N +P ++++P+ S + R+ ++ AKY E +Y R+
Sbjct: 482 GTSELL--LAKNIGNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERRYARKK 539
Query: 653 HPLFGNQEELDKALCAAVTTTDL 675
H N +L +LC AV T D+
Sbjct: 540 HA--DNAAKL-HSLCEAVKTRDI 559
Score = 47.8 bits (112), Expect = 8e-05
Identities = 44/133 (33%), Positives = 58/133 (43%), Gaps = 24/133 (18%)
Query: 91 SPPVPATPPEPLPTTTEDEGLPAAPPIPPRRSCLPPTCFTTPSTAAPDPVL------PPL 144
SPP PA P P T+ APP+PPR P T P A P + P
Sbjct: 770 SPP-PAQPAAPSTTS--------APPLPPRNVGKDPLTPTPPPPVAKTPSVMEALSQPSK 820
Query: 145 PAKRHLAELSVPPVPPRTGPPRLLVSLPTKEEESLLPSLSSPPQPQSEEPLS-TLPQGP- 202
PA ++++ PP+PP+ P RL P + P L++ QP+ LS T GP
Sbjct: 821 PAPPGISQIRPPPLPPQP-PSRLPQKKPAPGADKSTP-LTNKGQPRGPVDLSATEALGPL 878
Query: 203 -----PQPPSPPP 210
QPP+P P
Sbjct: 879 SNAMVLQPPAPMP 891
Score = 40.0 bits (92), Expect = 0.016
Identities = 29/95 (30%), Positives = 39/95 (41%), Gaps = 22/95 (23%)
Query: 134 TAAPDPVLPPLPAKRHLAELSVPPVPPR---------TGPPRLLVSLPTKEEESLLPSLS 184
+ +P P P P+ S PP+PPR T PP P + S++ +LS
Sbjct: 768 SGSPPPAQPAAPSTT-----SAPPLPPRNVGKDPLTPTPPP------PVAKTPSVMEALS 816
Query: 185 SPPQPQSEEPLSTLPQGPPQPPSPPPCPPEIPPKP 219
P +P P PP PP PP P+ P P
Sbjct: 817 QPSKPAPPGISQIRP--PPLPPQPPSRLPQKKPAP 849
Score = 32.3 bits (72), Expect = 3.4
Identities = 13/33 (39%), Positives = 23/33 (69%)
Query: 388 FEVITNNRTFAFRAESDVERKEWMQALQQAMAE 420
F++I+++RT+ F+AE + E + WM LQ + E
Sbjct: 366 FDLISHDRTYHFQAEDEQECQIWMSVLQNSKEE 398
>gi|4502249 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
isoform a [Homo sapiens]
Length = 1006
Score = 95.5 bits (236), Expect = 3e-19
Identities = 63/203 (31%), Positives = 100/203 (49%), Gaps = 26/203 (12%)
Query: 494 DRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALS------------------TS 535
+++ FDL + R + F A+ E E + W+ +Q + EAL+ T
Sbjct: 362 EKKCFDLISHDRTYHFQAEDEQECQIWMSVLQNSKEEALNNAFKGDDNTGENNIVQELTK 421
Query: 536 EVAERIWAAAPNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRK 595
E+ + N C DCGAP P W S NL ++ C C+G HR LG S+++SL +D
Sbjct: 422 EIISEVQRMTGNDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSLTLDVL 481
Query: 596 VWTETLIELFLQLGNGAGNRFWAANVPPSEALQPS--SSPSTRRCHLEAKYREGKY-RRY 652
+E L L +GN N +P ++++P+ S + R+ ++ AKY E +Y R+
Sbjct: 482 GTSELL--LAKNIGNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERRYARKK 539
Query: 653 HPLFGNQEELDKALCAAVTTTDL 675
H N +L +LC AV T D+
Sbjct: 540 HA--DNAAKL-HSLCEAVKTRDI 559
Score = 43.5 bits (101), Expect = 0.001
Identities = 41/139 (29%), Positives = 52/139 (37%), Gaps = 31/139 (22%)
Query: 91 SPPVPATPPEPLPTTTEDEGLPAAPPIPPRRSCLPPTCFTTP-----------------S 133
SPP PA P P T+ APP+PPR T + S
Sbjct: 770 SPP-PAQPAAPSTTS--------APPLPPRNVGKVQTASSANTLWKTNSVSVDGGSRQRS 820
Query: 134 TAAPDPVLPPLPAKRHLAELSVPPVPPRTGPPRLLVSLPTKEEESLLPSLSSPPQPQSEE 193
++ P V PPLP R + + P PP PP + P+ E PS +PP
Sbjct: 821 SSDPPAVHPPLPPLRVTSTNPLTPTPP---PP--VAKTPSVMEALSQPSKPAPPGISQIR 875
Query: 194 PLSTLPQGPPQPPSPPPCP 212
P PQ P + P P P
Sbjct: 876 PPPLPPQPPSRLPQKKPAP 894
Score = 32.3 bits (72), Expect = 3.4
Identities = 13/33 (39%), Positives = 23/33 (69%)
Query: 388 FEVITNNRTFAFRAESDVERKEWMQALQQAMAE 420
F++I+++RT+ F+AE + E + WM LQ + E
Sbjct: 366 FDLISHDRTYHFQAEDEQECQIWMSVLQNSKEE 398
Score = 30.8 bits (68), Expect = 9.9
Identities = 44/177 (24%), Positives = 59/177 (33%), Gaps = 34/177 (19%)
Query: 115 PPIPPRRSCLPPTCFTTPSTAAPDPVLPPLPAKRHLAELSVPPVPPRTGPPRLLVSLPTK 174
PP+PP R T P T P P + P+ + LS P P G
Sbjct: 829 PPLPPLR-----VTSTNPLTPTPPPPVAKTPSV--MEALSQPSKPAPPG----------- 870
Query: 175 EEESLLPSLSSPPQPQSEEPLSTLPQGPPQP---PSPPPCPPEIPPKPVRLFPEFDDSDY 231
+ + PP P +P S LPQ P P S P P PV L
Sbjct: 871 -----ISQIRPPPLP--PQPPSRLPQKKPAPGADKSTPLTNKGQPRGPVDLSATEALGPL 923
Query: 232 DEVPEEGPGAPARVMTKKEEPPPSRVPRAVRVAS------LLSEGEELSGDDQGDEE 282
P AP ++ + P RV + SEG+ + D + D+E
Sbjct: 924 SNAMVLQPPAPMPRKSQATKLKPKRVKALYNCVADNPDELTFSEGDVIIVDGEEDQE 980
>gi|46094081 development and differentiation enhancing factor 1
[Homo sapiens]
Length = 1129
Score = 94.7 bits (234), Expect = 6e-19
Identities = 54/176 (30%), Positives = 90/176 (51%), Gaps = 20/176 (11%)
Query: 494 DRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALS-----------------TSE 536
D++SFDL + R + F A+ E + W+ + + EAL+ T
Sbjct: 381 DKKSFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQSAGENSLEDLTKA 440
Query: 537 VAERIWAAAPNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKV 596
+ E + N C DCG+ +P W S NL ++ C C+G HR +G +S+++SL++D+
Sbjct: 441 IIEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLELDKLG 500
Query: 597 WTETLIELFLQLGNGAGNRFWAANVP-PSEALQPSSSPSTRRCHLEAKYREGKYRR 651
+E L L +GN + N AN+P PS PSS + R+ ++ AKY + ++ R
Sbjct: 501 TSELL--LAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKEYITAKYVDHRFSR 554
Score = 50.8 bits (120), Expect = 9e-06
Identities = 54/199 (27%), Positives = 67/199 (33%), Gaps = 61/199 (30%)
Query: 91 SPPVPATPPEPLPTTTEDEGLPAAPPIPPRRSCLPPTCFTTPSTAAPDPVLPPLPAKRHL 150
SP P T PLP +G P PP S LP + T+ ++ PP P H
Sbjct: 782 SPTSPTTEAPPLPPRNAGKG-PTGPP-----STLPLSTQTSSGSSTLSKKRPPPPPPGHK 835
Query: 151 AELSVPPVPPRTGP-----------------------------------------PRLLV 169
LS PP P GP PR+L
Sbjct: 836 RTLSDPPSPLPHGPPNKGAVPWGNDGGPSSSSKTTNKFEGLSQQSSTSSAKTALGPRVLP 895
Query: 170 SLP-----TKEEESLLPSLSSPPQP-QSEEPLSTLPQGPPQPPSPPPCPPEIPPKPVRLF 223
LP K + L + PP+ Q L+ LPQ PP P ++PPKP L
Sbjct: 896 KLPQKVALRKTDHLSLDKATIPPEIFQKSSQLAELPQKPP--------PGDLPPKPTELA 947
Query: 224 PEFDDSDYDEVPEEGPGAP 242
P+ D P E P P
Sbjct: 948 PKPQIGDLPPKPGELPPKP 966
Score = 43.1 bits (100), Expect = 0.002
Identities = 55/234 (23%), Positives = 87/234 (37%), Gaps = 19/234 (8%)
Query: 71 PAPAPRPTPRPVPMKRHIFRSPPVPATPPEPLPTTTEDEGLPAAPPIPPRRSCLPPTCFT 130
P+ + + T + + + S A P LP + L + ++ +PP F
Sbjct: 863 PSSSSKTTNKFEGLSQQSSTSSAKTALGPRVLPKLPQKVALRKTDHLSLDKATIPPEIFQ 922
Query: 131 TPSTAAPDPVLPP---LPAKRHLAELSVPP----VPPRTG--PPR-LLVSLPTKEEESLL 180
S A P PP LP K EL+ P +PP+ G PP+ L LP K + S L
Sbjct: 923 KSSQLAELPQKPPPGDLPPKP--TELAPKPQIGDLPPKPGELPPKPQLGDLPPKPQLSDL 980
Query: 181 PSLSS----PPQPQSEEPLSTLPQGPPQPPSPPPCPPEIPPKPVRLFPEFDDSDYDEVPE 236
P PP+PQ + L+ G P + P + P+ L P D +
Sbjct: 981 PPKPQMKDLPPKPQLGDLLAKSQTGDVSPKAQQPSEVTLKSHPLDLSPNVQSRD---AIQ 1037
Query: 237 EGPGAPARVMTKKEEPPPSRVPRAVRVASLLSEGEELSGDDQGDEEEDDHAYEG 290
+ + +T P +PR + + D Q D +++ EG
Sbjct: 1038 KQASEDSNDLTPTLPETPVPLPRKINTGKNKVRRVKTIYDCQADNDDELTFIEG 1091
Score = 32.7 bits (73), Expect = 2.6
Identities = 44/215 (20%), Positives = 82/215 (38%), Gaps = 26/215 (12%)
Query: 330 KAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKDAYSKRFISVACISHVAAIGDQKFE 389
K G+L K ++Q+R + L + + + + C A + F+
Sbjct: 327 KKGYLLKKSDGIRKVWQRRKCSVKNGILTISHATSNRQPAKLNLLTCQVKPNAEDKKSFD 386
Query: 390 VITNNRTFAFRAESDVERKEWMQALQQAMAE-------------QRARARLSSAYLLGV- 435
+I++NRT+ F+AE + + W+ L + E + + L+ A + V
Sbjct: 387 LISHNRTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQSAGENSLEDLTKAIIEDVQ 446
Query: 436 --PGSEQPDRAGSLELRGFKNKLYVAV----------VGDKVQLYKNLEEYHLGIGITFI 483
PG++ GS E L + +G + ++LE LG +
Sbjct: 447 RLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLELDKLGTSELLL 506
Query: 484 DMSVGNVKEVDRRSFDLTTPYRIFSFSADSELEKE 518
+VGN D +L +P + S+D + KE
Sbjct: 507 AKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKE 541
>gi|187608516 centaurin, beta 2 [Homo sapiens]
Length = 778
Score = 94.7 bits (234), Expect = 6e-19
Identities = 60/198 (30%), Positives = 91/198 (45%), Gaps = 36/198 (18%)
Query: 486 SVGNVKEVDRR-SFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEA------------- 531
+V + ++++RR F++ +P + ADSE ++ W++A+Q +IA A
Sbjct: 317 TVKHCEDIERRFCFEVVSPTKSCMLQADSEKLRQAWIKAVQTSIATAYREKGDESEKLDK 376
Query: 532 -------------------LSTSEVAERIWAAAPNRFCADCGAPQPDWASINLCVVICKR 572
L +R+ N C DCG P WASINL + +C
Sbjct: 377 KSSPSTGSLDSGNESKEKLLKGESALQRVQCIPGNASCCDCGLADPRWASINLGITLCIE 436
Query: 573 CAGEHRGLGAGVSKVRSLKMDRKVWTETLIELFLQLGNGAGNRFWAANVPPSEALQPS-S 631
C+G HR LG SKVRSL +D W L++L +LGN NR + ANV +P
Sbjct: 437 CSGIHRSLGVHFSKVRSLTLD--TWEPELLKLMCELGNDVINRVYEANVEKMGIKKPQPG 494
Query: 632 SPSTRRCHLEAKYREGKY 649
+ ++ AKY E K+
Sbjct: 495 QRQEKEAYIRAKYVERKF 512
Score = 33.5 bits (75), Expect = 1.5
Identities = 21/95 (22%), Positives = 45/95 (47%), Gaps = 3/95 (3%)
Query: 328 VIKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKD--AYSKRFISVACISHVAAIGD 385
++ G+L K + +RW + + L Y KD + + + H I
Sbjct: 267 IVMEGYLFKRASNAFKTWNRRWFSIQNNQLVYQKKFKDNPTVVVEDLRLCTVKHCEDIER 326
Query: 386 QK-FEVITNNRTFAFRAESDVERKEWMQALQQAMA 419
+ FEV++ ++ +A+S+ R+ W++A+Q ++A
Sbjct: 327 RFCFEVVSPTKSCMLQADSEKLRQAWIKAVQTSIA 361
>gi|34013590 Rho GTPase activating protein 2 [Homo sapiens]
Length = 698
Score = 94.7 bits (234), Expect = 6e-19
Identities = 86/304 (28%), Positives = 142/304 (46%), Gaps = 27/304 (8%)
Query: 881 EGWFSLSGSELRAVFPEGPCEEPLQLRKLQELSIQGDSENQVLVLVERRRTLYIQGERRL 940
+G+ SL G+++ + P GP E+P + L E+S G E + + L +R
Sbjct: 78 QGFISLQGTQVTEL-PPGP-EDPG--KHLFEISPGGAGEREKVPANPEALLLMASSQR-- 131
Query: 941 DFMGWLGAIQKAA-ASMGDTLSEQQL----------GDSDIPVIVYRCVDYITQCGLTSE 989
D W+ AI++ A +G + Q+L G P++V +CVD+I + GLT E
Sbjct: 132 DMEDWVQAIRRVIWAPLGGGIFGQRLEETVHHERKYGPRLAPLLVEQCVDFIRERGLTEE 191
Query: 990 GIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDVSSALKRFLRDLPDGLFTRAQRL 1049
G++R GQ + + L +S D L + V V+S LK +LR+LP+ + A+
Sbjct: 192 GLFRMPGQANLVRDLQDSF--DCGEKPLFDSTTDVHTVASLLKLYLRELPEPVVPFARYE 249
Query: 1050 TWLEASEI--EDEEEKVSRYRELLVRLPPVNRATVKALISHLYCVQCFSDTNQMNVHNLA 1107
+L +++ +DE E + + LP N ++ + L VQ +S+ N+M+V NLA
Sbjct: 250 DFLSCAQLLTKDEGEGTLELAKQVSNLPQANYNLLRYICKFLDEVQAYSNVNKMSVQNLA 309
Query: 1108 IVFGPTLFQTDGQDYKAGRVVEDLINHYVVVFSVDEEELRKQREEITAIVKMRVAGTASG 1167
VFGP + + +D L+ H + V +RK + TA V G
Sbjct: 310 TVFGPNILRPQVEDPVTIMEGTSLVQHLMTVL------IRKHSQLFTAPVPEGPTSPRGG 363
Query: 1168 TQHA 1171
Q A
Sbjct: 364 LQCA 367
Score = 38.9 bits (89), Expect = 0.036
Identities = 29/118 (24%), Positives = 46/118 (38%), Gaps = 10/118 (8%)
Query: 756 AGKLLQDRRAREEFSRRWCVLGDGVLSYFENERAVTPNGEIRASEIVCLAVPPPDTHGFE 815
AG L + R + + +RW VL L Y++++ + P G I +PP +
Sbjct: 41 AGWLKKQRSIMKNWQQRWFVLRGDQLFYYKDKDEIKPQGFISLQGTQVTELPPGPEDPGK 100
Query: 816 HTFEVYT--EGER--------LYLFGLESAEQAHEWVKCIAKAFVPPLAEDLLARDFE 863
H FE+ GER L S +WV+ I + PL + + E
Sbjct: 101 HLFEISPGGAGEREKVPANPEALLLMASSQRDMEDWVQAIRRVIWAPLGGGIFGQRLE 158
Score = 35.0 bits (79), Expect = 0.53
Identities = 29/111 (26%), Positives = 49/111 (44%), Gaps = 22/111 (19%)
Query: 327 PVIKAGWLDKNPPQGSYI--YQKRWVRLDTDHLRYFDSNKDAYSKRFISVACI------- 377
PV+KAGWL K Q S + +Q+RW L D L Y+ + + FIS+
Sbjct: 37 PVLKAGWLKK---QRSIMKNWQQRWFVLRGDQLFYYKDKDEIKPQGFISLQGTQVTELPP 93
Query: 378 ------SHVAAI----GDQKFEVITNNRTFAFRAESDVERKEWMQALQQAM 418
H+ I ++ +V N A S + ++W+QA+++ +
Sbjct: 94 GPEDPGKHLFEISPGGAGEREKVPANPEALLLMASSQRDMEDWVQAIRRVI 144
>gi|110227613 centaurin, gamma 3 isoform a [Homo sapiens]
Length = 911
Score = 92.4 bits (228), Expect = 3e-18
Identities = 65/225 (28%), Positives = 98/225 (43%), Gaps = 21/225 (9%)
Query: 509 FSADSELEKEQWLEAMQGAIAEALSTSEVA---------------ERIWAAAPNRFCADC 553
F A + E+E W++++Q I +L A + + N FC DC
Sbjct: 621 FEASTAEERELWVQSVQAQILASLQGCRSAKDKTRLGNQNAALAVQAVRTVRGNSFCIDC 680
Query: 554 GAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIELFLQLGNGAG 613
AP PDWAS+NL ++C C+G HR LGA +S+VRSL +D W L+ + +GN
Sbjct: 681 DAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDLDD--WPPELLAVMTAMGNALA 738
Query: 614 NRFWAANVPPSEALQPSSSPSTRRCHLEAKYREGKYRRYHPLFGNQEELDKALCAAVTTT 673
N W + P + + + AKY + + PL + L + L AV
Sbjct: 739 NSVWEGALGGYSKPGPDACREEKERWIRAKYEQKLF--LAPLPSSDVPLGQQLLRAVVED 796
Query: 674 DLAETQALLGCGA--GINCFSGDPEAPTPLALAEQAGQTLQMEFL 716
DL LL G+ +N GD + T L L+ + + L
Sbjct: 797 DLRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMANVVFTQLL 841
>gi|203097003 Rho GTPase activating protein 21 [Homo sapiens]
Length = 1958
Score = 92.4 bits (228), Expect = 3e-18
Identities = 64/196 (32%), Positives = 102/196 (52%), Gaps = 11/196 (5%)
Query: 970 IPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGE-QHVDDVS 1028
IP+IV C + + GL GIYR G + + E L + + +++ + + ++ +S
Sbjct: 1161 IPLIVDICCKLVEERGLEYTGIYRVPGNNAAISSMQEELNKGMADIDIQDDKWRDLNVIS 1220
Query: 1029 SALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISH 1088
S LK F R LP+ LFT + ++EA+ ED +++ + L+ LP + T+K L +H
Sbjct: 1221 SLLKSFFRKLPEPLFTNDKYADFIEANRKEDPLDRLKTLKRLIHDLPEHHYETLKFLSAH 1280
Query: 1089 LYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDY--------KAGRVVEDLINHYVVVFS 1140
L V S+ N+M NLAIVFGPTL +T + ++VE LI H+ F+
Sbjct: 1281 LKTVAENSEKNKMEPRNLAIVFGPTLVRTSEDNMTHMVTHMPDQYKIVETLIQHHDWFFT 1340
Query: 1141 VD--EEELRKQREEIT 1154
+ EE L +EE T
Sbjct: 1341 EEGAEEPLTTVQEEST 1356
>gi|188497642 ARHGAP15 [Homo sapiens]
Length = 475
Score = 91.7 bits (226), Expect = 5e-18
Identities = 53/186 (28%), Positives = 101/186 (54%), Gaps = 9/186 (4%)
Query: 967 DSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGE-QHVD 1025
+S +P V +C++ + + GL +GIYR G + Q+L + Q+ + ++L + + + +
Sbjct: 291 NSTVPWFVKQCIEAVEKRGLDVDGIYRVSGNLATIQKLRFIVNQEEK-LNLDDSQWEDIH 349
Query: 1026 DVSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKAL 1085
V+ ALK F R+LP+ LF + ++EA + +D ++ + L+ +LPP NR T+K L
Sbjct: 350 VVTGALKMFFRELPEPLFPYSFFEQFVEAIKKQDNNTRIEAVKSLVQKLPPPNRDTMKVL 409
Query: 1086 ISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQD-------YKAGRVVEDLINHYVVV 1138
HL + + N M+ +L IVFGPTL + + + ++ E +++ Y +
Sbjct: 410 FGHLTKIVAKASKNLMSTQSLGIVFGPTLLRAENETGNMAIHMVYQNQIAELMLSEYSKI 469
Query: 1139 FSVDEE 1144
F +E+
Sbjct: 470 FGSEED 475
>gi|47834348 minor histocompatibility antigen HA-1 [Homo sapiens]
Length = 1136
Score = 90.9 bits (224), Expect = 8e-18
Identities = 75/236 (31%), Positives = 105/236 (44%), Gaps = 42/236 (17%)
Query: 970 IPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDVSS 1029
+P IV +CV I + L ++GIYR G ++ ++L ++ V L + H D+S+
Sbjct: 774 VPFIVKKCVCEIERRALRTKGIYRVNGVKTRVEKLCQAFENGKELVELSQASPH--DISN 831
Query: 1030 ALKRFLRDLPDGL--FTRAQRLTWLEASEIEDEEEK--------------------VSRY 1067
LK +LR LP+ L F L L ++ E E R
Sbjct: 832 VLKLYLRQLPEPLISFRLYHELVGLAKDSLKAEAEAKAASRGRQDGSESEAVAVALAGRL 891
Query: 1068 RELLVRLPPVNRATVKALISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQ----------T 1117
RELL LPP NRA+++ L+ HL + N+M NL IVFGPTL + +
Sbjct: 892 RELLRDLPPENRASLQYLLRHLRRIVEVEQDNKMTPGNLGIVFGPTLLRPRPTEATVSLS 951
Query: 1118 DGQDY-KAGRVVEDLINHYVVVFSVDEEEL-------RKQREEITAIVKMRVAGTA 1165
DY RV+E LI HY +VF + EE QR E+ V AG A
Sbjct: 952 SLVDYPHQARVIETLIVHYGLVFEEEPEETPGGQDESSNQRAEVVVQVPYLEAGEA 1007
>gi|71834863 Rho GTPase activating protein 5 isoform a [Homo sapiens]
Length = 1502
Score = 90.9 bits (224), Expect = 8e-18
Identities = 54/162 (33%), Positives = 85/162 (52%), Gaps = 1/162 (0%)
Query: 957 GDTLSEQQLGDSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVH 1016
G L + + IP+ V +CV++I GL +EG+YR G + + + QD +++
Sbjct: 1261 GMPLQDLVTAEKPIPLFVEKCVEFIEDTGLCTEGLYRVSGNKTDQDNIQKQFDQD-HNIN 1319
Query: 1017 LKEGEQHVDDVSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPP 1076
L E V+ V+ ALK F DLPD L + LEA++I D+ E++ +E++ + P
Sbjct: 1320 LVSMEVTVNAVAGALKAFFADLPDPLIPYSLHPELLEAAKIPDKTERLHALKEIVKKFHP 1379
Query: 1077 VNRATVKALISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTD 1118
VN + +I+HL V N M NL+I F PTL + D
Sbjct: 1380 VNYDVFRYVITHLNRVSQQHKINLMTADNLSICFWPTLMRPD 1421
>gi|71834861 Rho GTPase activating protein 5 isoform b [Homo sapiens]
Length = 1501
Score = 90.9 bits (224), Expect = 8e-18
Identities = 54/162 (33%), Positives = 85/162 (52%), Gaps = 1/162 (0%)
Query: 957 GDTLSEQQLGDSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVH 1016
G L + + IP+ V +CV++I GL +EG+YR G + + + QD +++
Sbjct: 1260 GMPLQDLVTAEKPIPLFVEKCVEFIEDTGLCTEGLYRVSGNKTDQDNIQKQFDQD-HNIN 1318
Query: 1017 LKEGEQHVDDVSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPP 1076
L E V+ V+ ALK F DLPD L + LEA++I D+ E++ +E++ + P
Sbjct: 1319 LVSMEVTVNAVAGALKAFFADLPDPLIPYSLHPELLEAAKIPDKTERLHALKEIVKKFHP 1378
Query: 1077 VNRATVKALISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTD 1118
VN + +I+HL V N M NL+I F PTL + D
Sbjct: 1379 VNYDVFRYVITHLNRVSQQHKINLMTADNLSICFWPTLMRPD 1420
>gi|221307473 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
isoform b [Homo sapiens]
Length = 894
Score = 90.5 bits (223), Expect = 1e-17
Identities = 62/186 (33%), Positives = 90/186 (48%), Gaps = 30/186 (16%)
Query: 494 DRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERI-----WAAAP-- 546
+++ FDL T R + F A+ E E E W+ +Q + EALS++ + E W +A
Sbjct: 350 EKKCFDLVTHNRTYHFQAEDEHECEAWVSVLQNSKDEALSSAFLGEPSAGPGSWGSAGHD 409
Query: 547 -------------------NRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKV 587
N C DCGA P W S NL V+ C +C+G HR LG S++
Sbjct: 410 GEPHDLTKLLIAEVKSRPGNSQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVRFSRM 469
Query: 588 RSLKMDRKVWTETLIELFLQLGNGAGNRFWAANVPPSEALQPS--SSPSTRRCHLEAKYR 645
+SL +D +E L L L +GN + N A +P +PS S TRR ++ AKY
Sbjct: 470 QSLTLDLLGPSELL--LALNMGNTSFNEVMEAQLPSHGGPKPSAESDMGTRRDYIMAKYV 527
Query: 646 EGKYRR 651
E ++ R
Sbjct: 528 EHRFAR 533
Score = 36.2 bits (82), Expect = 0.24
Identities = 18/45 (40%), Positives = 29/45 (64%), Gaps = 5/45 (11%)
Query: 388 FEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARARLSSAYL 432
F+++T+NRT+ F+AE + E + W+ LQ + E LSSA+L
Sbjct: 354 FDLVTHNRTYHFQAEDEHECEAWVSVLQNSKDE-----ALSSAFL 393
>gi|19923540 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
isoform a [Homo sapiens]
Length = 903
Score = 90.5 bits (223), Expect = 1e-17
Identities = 62/186 (33%), Positives = 90/186 (48%), Gaps = 30/186 (16%)
Query: 494 DRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERI-----WAAAP-- 546
+++ FDL T R + F A+ E E E W+ +Q + EALS++ + E W +A
Sbjct: 359 EKKCFDLVTHNRTYHFQAEDEHECEAWVSVLQNSKDEALSSAFLGEPSAGPGSWGSAGHD 418
Query: 547 -------------------NRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKV 587
N C DCGA P W S NL V+ C +C+G HR LG S++
Sbjct: 419 GEPHDLTKLLIAEVKSRPGNSQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVRFSRM 478
Query: 588 RSLKMDRKVWTETLIELFLQLGNGAGNRFWAANVPPSEALQPS--SSPSTRRCHLEAKYR 645
+SL +D +E L L L +GN + N A +P +PS S TRR ++ AKY
Sbjct: 479 QSLTLDLLGPSELL--LALNMGNTSFNEVMEAQLPSHGGPKPSAESDMGTRRDYIMAKYV 536
Query: 646 EGKYRR 651
E ++ R
Sbjct: 537 EHRFAR 542
Score = 36.2 bits (82), Expect = 0.24
Identities = 18/45 (40%), Positives = 29/45 (64%), Gaps = 5/45 (11%)
Query: 388 FEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARARLSSAYL 432
F+++T+NRT+ F+AE + E + W+ LQ + E LSSA+L
Sbjct: 363 FDLVTHNRTYHFQAEDEHECEAWVSVLQNSKDE-----ALSSAFL 402
>gi|56119110 family with sequence similarity 13, member A1 isoform a
[Homo sapiens]
Length = 1023
Score = 90.5 bits (223), Expect = 1e-17
Identities = 60/192 (31%), Positives = 96/192 (50%), Gaps = 8/192 (4%)
Query: 960 LSEQQLGDSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKE 1019
L Q L ++ IP +V+ V+Y+TQ GLT EG++R G ++L K+
Sbjct: 48 LERQGLTENGIPAVVWNIVEYLTQHGLTQEGLFRVNGNVKVVEQLRLKFESGVPVELGKD 107
Query: 1020 GEQHVDDVSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNR 1079
G+ V +S LK FLR+LPD L T A + +++ + + + S R+L+ LP +
Sbjct: 108 GD--VCSAASLLKLFLRELPDSLITSALQPRFIQLFQDGRNDVQESSLRDLIKELPDTHY 165
Query: 1080 ATVKALISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQT----DGQDYK--AGRVVEDLIN 1133
+K L L V N+MNVHNLA VFGP F +G + +++ ++
Sbjct: 166 CLLKYLCQFLTKVAKHHVQNRMNVHNLATVFGPNCFHVPPGLEGMKEQDLCNKIMAKILE 225
Query: 1134 HYVVVFSVDEEE 1145
+Y +F V+ E
Sbjct: 226 NYNTLFEVEYTE 237
>gi|208022687 GTPase regulator associated with the focal adhesion
kinase pp125 isoform b [Homo sapiens]
Length = 759
Score = 88.2 bits (217), Expect = 5e-17
Identities = 64/230 (27%), Positives = 111/230 (48%), Gaps = 16/230 (6%)
Query: 926 VERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLSEQQLGDSDIPVI----VYRCVDYI 981
V+R + +Q D W+ A+ Q G + + I + +C+ +
Sbjct: 341 VDRPGVITMQALSEEDRRLWMEAMDGREPVYNSNKDSQSEGTAQLDSIGFSIIRKCIHAV 400
Query: 982 TQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKE----GEQHVDDVSSALKRFLRD 1037
G+ +G+YR G S+ Q+LL S+ D ++ E E + ++SALK +LR
Sbjct: 401 ETRGINEQGLYRIVGVNSRVQKLL-SVLMDPKTASETETDICAEWEIKTITSALKTYLRM 459
Query: 1038 LPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISHLYCVQCFSD 1097
LP L + ++++A+++E++E +VS L+ RLP NR ++ L++HL V
Sbjct: 460 LPGPLMMYQFQRSFIKAAKLENQESRVSEIHSLVHRLPEKNRQMLQLLMNHLANVANNHK 519
Query: 1098 TNQMNVHNLAIVFGPTLFQTDGQDYKA-------GRVVEDLINHYVVVFS 1140
N M V NL +VFGPTL + + A V+E LI ++ +F+
Sbjct: 520 QNLMTVANLGVVFGPTLLRPQEETVAAIMDIKFQNIVIEILIENHEKIFN 569
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.135 0.410
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 66,186,084
Number of Sequences: 37866
Number of extensions: 3961366
Number of successful extensions: 50582
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 542
Number of HSP's successfully gapped in prelim test: 1565
Number of HSP's that attempted gapping in prelim test: 21530
Number of HSP's gapped (non-prelim): 14092
length of query: 1450
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1335
effective length of database: 13,892,928
effective search space: 18547058880
effective search space used: 18547058880
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.