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Search of human proteins with 91176325
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|91176325 bromodomain adjacent to zinc finger domain, 2A
[Homo sapiens]
(1905 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|91176325 bromodomain adjacent to zinc finger domain, 2A [Homo... 3844 0.0
gi|94681063 bromodomain adjacent to zinc finger domain, 2B [Homo... 902 0.0
gi|14670392 bromodomain adjacent to zinc finger domain, 1B [Homo... 117 1e-25
gi|32967605 bromodomain adjacent to zinc finger domain, 1A isofo... 116 2e-25
gi|32967603 bromodomain adjacent to zinc finger domain, 1A isofo... 116 2e-25
gi|74027251 tripartite motif-containing 33 protein isoform beta ... 103 1e-21
gi|47419911 transcriptional intermediary factor 1 alpha isoform ... 101 6e-21
gi|47419909 transcriptional intermediary factor 1 alpha isoform ... 101 6e-21
gi|209977097 tripartite motif-containing 66 [Homo sapiens] 97 2e-19
gi|74027249 tripartite motif-containing 33 protein isoform alpha... 93 2e-18
gi|40805843 K(lysine) acetyltransferase 2B [Homo sapiens] 86 3e-16
gi|38788260 bromodomain PHD finger transcription factor isoform ... 84 2e-15
gi|38788274 bromodomain PHD finger transcription factor isoform ... 84 2e-15
gi|148612882 cat eye syndrome chromosome region, candidate 2 [Ho... 75 5e-13
gi|239749449 PREDICTED: hypothetical protein [Homo sapiens] 73 3e-12
gi|153791535 general control of amino acid synthesis 5-like 2 [H... 72 5e-12
gi|11067749 bromodomain containing protein 3 [Homo sapiens] 72 7e-12
gi|164419758 bromodomain containing 2 [Homo sapiens] 69 6e-11
gi|4826806 bromodomain containing 2 [Homo sapiens] 69 6e-11
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] 68 7e-11
gi|7657218 bromodomain-containing protein 4 isoform short [Homo ... 68 7e-11
gi|19718731 bromodomain-containing protein 4 isoform long [Homo ... 68 7e-11
gi|57242796 jumonji, AT rich interactive domain 1B [Homo sapiens] 66 4e-10
gi|169218173 PREDICTED: similar to Jumonji, AT rich interactive ... 66 4e-10
gi|153945728 microtubule-associated protein 1B [Homo sapiens] 65 6e-10
gi|150378543 MYST histone acetyltransferase (monocytic leukemia)... 65 8e-10
gi|150378463 MYST histone acetyltransferase (monocytic leukemia)... 65 8e-10
gi|150378493 MYST histone acetyltransferase (monocytic leukemia)... 65 8e-10
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 64 1e-09
gi|46399200 testis-specific bromodomain protein [Homo sapiens] 64 1e-09
>gi|91176325 bromodomain adjacent to zinc finger domain, 2A [Homo
sapiens]
Length = 1905
Score = 3844 bits (9968), Expect = 0.0
Identities = 1905/1905 (100%), Positives = 1905/1905 (100%)
Query: 1 MEMEANDHFNFTGLPPAPAASGLKPSPSSGEGLYTNGSPMNFPQQGKSLNGDVNVNGLST 60
MEMEANDHFNFTGLPPAPAASGLKPSPSSGEGLYTNGSPMNFPQQGKSLNGDVNVNGLST
Sbjct: 1 MEMEANDHFNFTGLPPAPAASGLKPSPSSGEGLYTNGSPMNFPQQGKSLNGDVNVNGLST 60
Query: 61 VSHTTTSGILNSAPHSSSTSHLHHPSVAYDCLWNYSQYPSANPGSNLKDPPLLSQFSGGQ 120
VSHTTTSGILNSAPHSSSTSHLHHPSVAYDCLWNYSQYPSANPGSNLKDPPLLSQFSGGQ
Sbjct: 61 VSHTTTSGILNSAPHSSSTSHLHHPSVAYDCLWNYSQYPSANPGSNLKDPPLLSQFSGGQ 120
Query: 121 YPLNGILGGSRQPSSPSHNTNLRAGSQEFWANGTQSPMGLNFDSQELYDSFPDQNFEVMP 180
YPLNGILGGSRQPSSPSHNTNLRAGSQEFWANGTQSPMGLNFDSQELYDSFPDQNFEVMP
Sbjct: 121 YPLNGILGGSRQPSSPSHNTNLRAGSQEFWANGTQSPMGLNFDSQELYDSFPDQNFEVMP 180
Query: 181 NGPPSFFTSPQTSPMLGSSIQTFAPSQEVGSGIHPDEAAEKEMTSVVAENGTGLVGSLEL 240
NGPPSFFTSPQTSPMLGSSIQTFAPSQEVGSGIHPDEAAEKEMTSVVAENGTGLVGSLEL
Sbjct: 181 NGPPSFFTSPQTSPMLGSSIQTFAPSQEVGSGIHPDEAAEKEMTSVVAENGTGLVGSLEL 240
Query: 241 EEEQPELKMCGYNGSVPSVESLHQEVSVLVPDPTVSCLDDPSHLPDQLEDTPILSEDSLE 300
EEEQPELKMCGYNGSVPSVESLHQEVSVLVPDPTVSCLDDPSHLPDQLEDTPILSEDSLE
Sbjct: 241 EEEQPELKMCGYNGSVPSVESLHQEVSVLVPDPTVSCLDDPSHLPDQLEDTPILSEDSLE 300
Query: 301 PFNSLAPEPVSGGLYGIDDTELMGAEDKLPLEDSPVISALDCPSLNNATAFSLLADDSQT 360
PFNSLAPEPVSGGLYGIDDTELMGAEDKLPLEDSPVISALDCPSLNNATAFSLLADDSQT
Sbjct: 301 PFNSLAPEPVSGGLYGIDDTELMGAEDKLPLEDSPVISALDCPSLNNATAFSLLADDSQT 360
Query: 361 STSIFASPTSPPVLGESVLQDNSFDLNNGSDAEQEEMETQSSDFPPSLTQPAPDQSSTIQ 420
STSIFASPTSPPVLGESVLQDNSFDLNNGSDAEQEEMETQSSDFPPSLTQPAPDQSSTIQ
Sbjct: 361 STSIFASPTSPPVLGESVLQDNSFDLNNGSDAEQEEMETQSSDFPPSLTQPAPDQSSTIQ 420
Query: 421 LHPATSPAVSPTTSPAVSLVVSPAASPEISPEVCPAASTVVSPAVFSVVSPASSAVLPAV 480
LHPATSPAVSPTTSPAVSLVVSPAASPEISPEVCPAASTVVSPAVFSVVSPASSAVLPAV
Sbjct: 421 LHPATSPAVSPTTSPAVSLVVSPAASPEISPEVCPAASTVVSPAVFSVVSPASSAVLPAV 480
Query: 481 SLEVPLTASVTSPKASPVTSPAAAFPTASPANKDVSSFLETTADVEEITGEGLTASGSGD 540
SLEVPLTASVTSPKASPVTSPAAAFPTASPANKDVSSFLETTADVEEITGEGLTASGSGD
Sbjct: 481 SLEVPLTASVTSPKASPVTSPAAAFPTASPANKDVSSFLETTADVEEITGEGLTASGSGD 540
Query: 541 VMRRRIATPEEVRLPLQHGWRREVRIKKGSHRWQGETWYYGPCGKRMKQFPEVIKYLSRN 600
VMRRRIATPEEVRLPLQHGWRREVRIKKGSHRWQGETWYYGPCGKRMKQFPEVIKYLSRN
Sbjct: 541 VMRRRIATPEEVRLPLQHGWRREVRIKKGSHRWQGETWYYGPCGKRMKQFPEVIKYLSRN 600
Query: 601 VVHSVRREHFSFSPRMPVGDFFEERDTPEGLQWVQLSAEEIPSRIQAITGKRGRPRNTEK 660
VVHSVRREHFSFSPRMPVGDFFEERDTPEGLQWVQLSAEEIPSRIQAITGKRGRPRNTEK
Sbjct: 601 VVHSVRREHFSFSPRMPVGDFFEERDTPEGLQWVQLSAEEIPSRIQAITGKRGRPRNTEK 660
Query: 661 AKTKEVPKVKRGRGRPPKVKITELLNKTDNRPLKKLEAQETLNEEDKAKIAKSKKKMRQK 720
AKTKEVPKVKRGRGRPPKVKITELLNKTDNRPLKKLEAQETLNEEDKAKIAKSKKKMRQK
Sbjct: 661 AKTKEVPKVKRGRGRPPKVKITELLNKTDNRPLKKLEAQETLNEEDKAKIAKSKKKMRQK 720
Query: 721 VQRGECQTTIQGQARNKRKQETKSLKQKEAKKKSKAEKEKGKTKQEKLKEKVKREKKEKV 780
VQRGECQTTIQGQARNKRKQETKSLKQKEAKKKSKAEKEKGKTKQEKLKEKVKREKKEKV
Sbjct: 721 VQRGECQTTIQGQARNKRKQETKSLKQKEAKKKSKAEKEKGKTKQEKLKEKVKREKKEKV 780
Query: 781 KMKEKEEVTKAKPACKADKTLATQRRLEERQRQQMILEEMKKPTEDMCLTDHQPLPDFSR 840
KMKEKEEVTKAKPACKADKTLATQRRLEERQRQQMILEEMKKPTEDMCLTDHQPLPDFSR
Sbjct: 781 KMKEKEEVTKAKPACKADKTLATQRRLEERQRQQMILEEMKKPTEDMCLTDHQPLPDFSR 840
Query: 841 VPGLTLPSGAFSDCLTIVEFLHSFGKVLGFDPAKDVPSLGVLQEGLLCQGDSLGEVQDLL 900
VPGLTLPSGAFSDCLTIVEFLHSFGKVLGFDPAKDVPSLGVLQEGLLCQGDSLGEVQDLL
Sbjct: 841 VPGLTLPSGAFSDCLTIVEFLHSFGKVLGFDPAKDVPSLGVLQEGLLCQGDSLGEVQDLL 900
Query: 901 VRLLKAALHDPGFPSYCQSLKILGEKVSEIPLTRDNVSEILRCFLMAYGVEPALCDRLRT 960
VRLLKAALHDPGFPSYCQSLKILGEKVSEIPLTRDNVSEILRCFLMAYGVEPALCDRLRT
Sbjct: 901 VRLLKAALHDPGFPSYCQSLKILGEKVSEIPLTRDNVSEILRCFLMAYGVEPALCDRLRT 960
Query: 961 QPFQAQPPQQKAAVLAFLVHELNGSTLIINEIDKTLESMSSYRKNKWIVEGRLRRLKTVL 1020
QPFQAQPPQQKAAVLAFLVHELNGSTLIINEIDKTLESMSSYRKNKWIVEGRLRRLKTVL
Sbjct: 961 QPFQAQPPQQKAAVLAFLVHELNGSTLIINEIDKTLESMSSYRKNKWIVEGRLRRLKTVL 1020
Query: 1021 AKRTGRSEVEMEGPEECLGRRRSSRIMEETSGMEEEEEEESIAAVPGRRGRRDGEVDATA 1080
AKRTGRSEVEMEGPEECLGRRRSSRIMEETSGMEEEEEEESIAAVPGRRGRRDGEVDATA
Sbjct: 1021 AKRTGRSEVEMEGPEECLGRRRSSRIMEETSGMEEEEEEESIAAVPGRRGRRDGEVDATA 1080
Query: 1081 SSIPELERQIEKLSKRQLFFRKKLLHSSQMLRAVSLGQDRYRRRYWVLPYLAGIFVEGTE 1140
SSIPELERQIEKLSKRQLFFRKKLLHSSQMLRAVSLGQDRYRRRYWVLPYLAGIFVEGTE
Sbjct: 1081 SSIPELERQIEKLSKRQLFFRKKLLHSSQMLRAVSLGQDRYRRRYWVLPYLAGIFVEGTE 1140
Query: 1141 GNLVPEEVIKKETDSLKVAAHASLNPALFSMKMELAGSNTTASSPARARGRPRKTKPGSM 1200
GNLVPEEVIKKETDSLKVAAHASLNPALFSMKMELAGSNTTASSPARARGRPRKTKPGSM
Sbjct: 1141 GNLVPEEVIKKETDSLKVAAHASLNPALFSMKMELAGSNTTASSPARARGRPRKTKPGSM 1200
Query: 1201 QPRHLKSPVRGQDSEQPQAQLQPEAQLHAPAQPQPQLQLQLQSHKGFLEQEGSPLSLGQS 1260
QPRHLKSPVRGQDSEQPQAQLQPEAQLHAPAQPQPQLQLQLQSHKGFLEQEGSPLSLGQS
Sbjct: 1201 QPRHLKSPVRGQDSEQPQAQLQPEAQLHAPAQPQPQLQLQLQSHKGFLEQEGSPLSLGQS 1260
Query: 1261 QHDLSQSAFLSWLSQTQSHSSLLSSSVLTPDSSPGKLDPAPSQPPEEPEPDEAESSPDPQ 1320
QHDLSQSAFLSWLSQTQSHSSLLSSSVLTPDSSPGKLDPAPSQPPEEPEPDEAESSPDPQ
Sbjct: 1261 QHDLSQSAFLSWLSQTQSHSSLLSSSVLTPDSSPGKLDPAPSQPPEEPEPDEAESSPDPQ 1320
Query: 1321 ALWFNISAQMPCNAAPTPPPAVSEDQPTPSPQQLASSKPMNRPSAANPCSPVQFSSTPLA 1380
ALWFNISAQMPCNAAPTPPPAVSEDQPTPSPQQLASSKPMNRPSAANPCSPVQFSSTPLA
Sbjct: 1321 ALWFNISAQMPCNAAPTPPPAVSEDQPTPSPQQLASSKPMNRPSAANPCSPVQFSSTPLA 1380
Query: 1381 GLAPKRRAGDPGEMPQSPTGLGQPKRRGRPPSKFFKQMEQRYLTQLTAQPVPPEMCSGWW 1440
GLAPKRRAGDPGEMPQSPTGLGQPKRRGRPPSKFFKQMEQRYLTQLTAQPVPPEMCSGWW
Sbjct: 1381 GLAPKRRAGDPGEMPQSPTGLGQPKRRGRPPSKFFKQMEQRYLTQLTAQPVPPEMCSGWW 1440
Query: 1441 WIRDPEMLDAMLKALHPRGIREKALHKHLNKHRDFLQEVCLRPSADPIFEPRQLPAFQEG 1500
WIRDPEMLDAMLKALHPRGIREKALHKHLNKHRDFLQEVCLRPSADPIFEPRQLPAFQEG
Sbjct: 1441 WIRDPEMLDAMLKALHPRGIREKALHKHLNKHRDFLQEVCLRPSADPIFEPRQLPAFQEG 1500
Query: 1501 IMSWSPKEKTYETDLAVLQWVEELEQRVIMSDLQIRGWTCPSPDSTREDLAYCEHLSDSQ 1560
IMSWSPKEKTYETDLAVLQWVEELEQRVIMSDLQIRGWTCPSPDSTREDLAYCEHLSDSQ
Sbjct: 1501 IMSWSPKEKTYETDLAVLQWVEELEQRVIMSDLQIRGWTCPSPDSTREDLAYCEHLSDSQ 1560
Query: 1561 EDITWRGRGREGLAPQRKTTNPLDLAVMRLAALEQNVERRYLREPLWPTHEVVLEKALLS 1620
EDITWRGRGREGLAPQRKTTNPLDLAVMRLAALEQNVERRYLREPLWPTHEVVLEKALLS
Sbjct: 1561 EDITWRGRGREGLAPQRKTTNPLDLAVMRLAALEQNVERRYLREPLWPTHEVVLEKALLS 1620
Query: 1621 TPNGAPEGTTTEISYEITPRIRVWRQTLERCRSAAQVCLCLGQLERSIAWEKSVNKVTCL 1680
TPNGAPEGTTTEISYEITPRIRVWRQTLERCRSAAQVCLCLGQLERSIAWEKSVNKVTCL
Sbjct: 1621 TPNGAPEGTTTEISYEITPRIRVWRQTLERCRSAAQVCLCLGQLERSIAWEKSVNKVTCL 1680
Query: 1681 VCRKGDNDEFLLLCDGCDRGCHIYCHRPKMEAVPEGDWFCTVCLAQQVEGEFTQKPGFPK 1740
VCRKGDNDEFLLLCDGCDRGCHIYCHRPKMEAVPEGDWFCTVCLAQQVEGEFTQKPGFPK
Sbjct: 1681 VCRKGDNDEFLLLCDGCDRGCHIYCHRPKMEAVPEGDWFCTVCLAQQVEGEFTQKPGFPK 1740
Query: 1741 RGQKRKSGYSLNFSEGDGRRRRVLLRGRESPAAGPRYSEEGLSPSKRRRLSMRNHHSDLT 1800
RGQKRKSGYSLNFSEGDGRRRRVLLRGRESPAAGPRYSEEGLSPSKRRRLSMRNHHSDLT
Sbjct: 1741 RGQKRKSGYSLNFSEGDGRRRRVLLRGRESPAAGPRYSEEGLSPSKRRRLSMRNHHSDLT 1800
Query: 1801 FCEIILMEMESHDAAWPFLEPVNPRLVSGYRRIIKNPMDFSTMRERLLRGGYTSSEEFAA 1860
FCEIILMEMESHDAAWPFLEPVNPRLVSGYRRIIKNPMDFSTMRERLLRGGYTSSEEFAA
Sbjct: 1801 FCEIILMEMESHDAAWPFLEPVNPRLVSGYRRIIKNPMDFSTMRERLLRGGYTSSEEFAA 1860
Query: 1861 DALLVFDNCQTFNEDDSEVGKAGHIMRRFFESRWEEFYQGKQANL 1905
DALLVFDNCQTFNEDDSEVGKAGHIMRRFFESRWEEFYQGKQANL
Sbjct: 1861 DALLVFDNCQTFNEDDSEVGKAGHIMRRFFESRWEEFYQGKQANL 1905
>gi|94681063 bromodomain adjacent to zinc finger domain, 2B [Homo
sapiens]
Length = 2168
Score = 902 bits (2330), Expect = 0.0
Identities = 570/1570 (36%), Positives = 837/1570 (53%), Gaps = 223/1570 (14%)
Query: 473 SSAVLPAVSLEVPLTASVTSPKASPVTSPAAAFPTASPANKDVSSFLETTADVEEITGEG 532
SS P++SL ++P+ + + P A + +FL T++
Sbjct: 677 SSVKSPSMSL-----TGHSTPRNLHIAKAPGSAPAALCSESQSPAFLGTSSST------- 724
Query: 533 LTASG-SGDVMRRRIATPEEVRLPLQHGWRREVRIKKGSHRWQGETWYYGPCGKRMKQFP 591
LT+S SG RRR+ E+R+PL++GW+RE RI+ R QGE YY PCGK+++Q+P
Sbjct: 725 LTSSPHSGTSKRRRVTDERELRIPLEYGWQRETRIRNFGGRLQGEVAYYAPCGKKLRQYP 784
Query: 592 EVIKYLSRNVVHSVRREHFSFSPRMPVGDFFEERDTPEGLQWVQLSAEEIPSRIQAITGK 651
EVIKYLSRN + + R++FSFS ++ VGDF+E RD P+G+QW L E++ RI+A+ G+
Sbjct: 785 EVIKYLSRNGIMDISRDNFSFSAKIRVGDFYEARDGPQGMQWCLLKEEDVIPRIRAMEGR 844
Query: 652 RGRPRNTEKAKTKEVPKVKRGRGRPPKVKITELLNKTDNRPLKKLEAQET---------- 701
RGRP N ++ + +E +++R +GRPP V E L+ D + L+KL+AQE
Sbjct: 845 RGRPPNPDRQRAREESRMRRRKGRPPNVGNAEFLDNADAKLLRKLQAQEIARQAAQIKLL 904
Query: 702 --LNEEDKAKIAKSKKKMR------------------------QKVQRGECQTTIQGQ-- 733
L ++++A++AK KK + +++Q+ + ++ Q
Sbjct: 905 RKLQKQEQARVAKEAKKQQAIMAAEEKRKQKEQIKIMKQQEKIKRIQQIRMEKELRAQQI 964
Query: 734 --ARNKRKQETKSLKQKEAKKKSKAEKEKGKTKQEKLKEKVKREKKEKVKM-------KE 784
A+ K+K+E + K EA+K+ K EKE + + LK + + +++ + + K+
Sbjct: 965 LEAKKKKKEEAANAKLLEAEKRIK-EKEMRRQQAVLLKHQERERRRQHMMLMKAMEARKK 1023
Query: 785 KEEVTKAKPACKADKTLATQRRLEERQRQQMILEEMKKPTEDMCLTDHQPLPDFSRVPGL 844
EE + K + +K L +R+LE+R+ + + +E+KKP EDMCL D +PLP+ R+PGL
Sbjct: 1024 AEEKERLKQEKRDEKRLNKERKLEQRRLELEMAKELKKPNEDMCLADQKPLPELPRIPGL 1083
Query: 845 TLPSGAFSDCLTIVEFLHSFGKVLGFDPAKDVPSLGVLQEGLLCQGDSLGEVQDLLVRLL 904
L FSDCL +V+FL +FGKVLGFD DVP+L VLQEGLL GDS+GEVQDLLVRLL
Sbjct: 1084 VLSGSTFSDCLMVVQFLRNFGKVLGFDVNIDVPNLSVLQEGLLNIGDSMGEVQDLLVRLL 1143
Query: 905 KAALHDPGFPSYCQSLKILGEKVSEIPLTRDNVSEILRCFLMAYGVEPALCDRLRTQPFQ 964
AA+ DPG + ++ LGE + + + RDNVSEIL+ F+ A+ + L + L+T+ FQ
Sbjct: 1144 SAAVCDPGLITGYKAKTALGEHLLNVGVNRDNVSEILQIFMEAHCGQTELTESLKTKAFQ 1203
Query: 965 AQPPQQKAAVLAFLVHELNGSTLIINEIDKTLESMSSYRKNKWIVEGRLRRLKTVLAKRT 1024
A P QKA+VLAFL++EL S +++EIDK ++ MS+ R++KW+VEG+LR+L+ + AK+T
Sbjct: 1204 AHTPAQKASVLAFLINELACSKSVVSEIDKNIDYMSNLRRDKWVVEGKLRKLRIIHAKKT 1263
Query: 1025 GRSE----VEMEGPEECLG-------RRRSSRIME---------ETSGMEEEEEEESIAA 1064
G+ + +++ + LG RRR + + G E++E+EE
Sbjct: 1264 GKRDTSGGIDLGEEQHPLGTPTPGRKRRRKGGDSDYDDDDDDDSDDQGDEDDEDEEDKED 1323
Query: 1065 VPGRRGR--RDGEVDATASSIPELERQIEKLSKRQLFFRKKLLHSSQMLRAVSLGQDRYR 1122
G++ D + A+S+ ELE+QIEKLSK+Q +R+KL +S LR+V GQDRYR
Sbjct: 1324 KKGKKTDICEDEDEGDQAASVEELEKQIEKLSKQQSQYRRKLFDASHSLRSVMFGQDRYR 1383
Query: 1123 RRYWVLPYLAGIFVEGTEGNLVPEEVIKKETDSLKVAAHASLNPALFSMKMELAGSNTTA 1182
RRYW+LP GIFVEG E EE I KE + LK A + +F + + T
Sbjct: 1384 RRYWILPQCGGIFVEGMESGEGLEE-IAKEREKLKKAESVQIKEEMFETSGDSLNCSNTD 1442
Query: 1183 SSPARARGRPRKT------KPGSMQPRHLKSPVRGQDSEQPQAQLQPEAQLHAPAQPQPQ 1236
+ + + KPGS V A++ PE+++ P +P
Sbjct: 1443 HCEQKEDLKEKDNTNLFLQKPGSFSKLSKLLEV---------AKMPPESEVMTP-KPNAG 1492
Query: 1237 LQLQLQSHKGFLEQEGSPLSLGQSQHDLSQSAFLSWLSQTQSHSSLLSSSVLTPDSSPGK 1296
S+ Q SLG Q +QS + ++ S+ L + T S PGK
Sbjct: 1493 ANGCTLSY-----QNSGKHSLGSVQSTATQS------NVEKADSNNLFN---TGSSGPGK 1538
Query: 1297 L-DPAPSQPPEEPEPDEAESSPDPQALWFNISAQMPCN--------------AAPTPPPA 1341
P P+ ++ + WF++ + PC+ P P
Sbjct: 1539 FYSPLPND-------QLLKTLTEKNRQWFSLLPRTPCDDTSLTHADMSTASLVTPQSQPP 1591
Query: 1342 VSEDQPTPSPQQLASSKPMN-RPSAANPCS--------PVQFSSTPLAGLAPKRRAGDPG 1392
PTP+P ++ P+ P A +P +QF P +
Sbjct: 1592 SKSPSPTPAPLGSSAQNPVGLNPFALSPLQVKGGVSMMGLQFCGWPTGVVT--SNIPFTS 1649
Query: 1393 EMPQSPTGLGQPKRRGR----------PPSKFFKQMEQRYLTQLTA------------QP 1430
+P +GLG + G Q E+ Q A +P
Sbjct: 1650 SVPSLGSGLGLSEGNGNSFLTSNVASSKSESPVPQNEKATSAQPAAVEVAKPVDFPSPKP 1709
Query: 1431 VPPEMCSGWWWIRDPEMLDAMLKALHPRGIREKALHKHLNKHRDFLQEVCLRPSADPIFE 1490
+P EM GWW I DPE L A+LK LH RGIREKAL K + KH D++ + CL+ I E
Sbjct: 1710 IPEEMQFGWWRIIDPEDLKALLKVLHLRGIREKALQKQIQKHLDYITQACLKNKDVAIIE 1769
Query: 1491 PRQLPAFQ---EGIMSWSPKEKTYETDLAVLQWVEELEQRVIMSDLQIRGWTCPSPDSTR 1547
+ Q + + +WS +E+ E DL+VLQ VE+LE+RV + LQ++GW CP P S R
Sbjct: 1770 LNENEENQVTRDIVENWSVEEQAMEMDLSVLQQVEDLERRVASASLQVKGWMCPEPASER 1829
Query: 1548 EDLAYCEHLSDS----QEDITWRGRGREGL-APQRKTTNPLDLAVMRLAALEQNVERRYL 1602
EDL Y EH S + + D + G A +RK+ NPLD+AV RLA LE+N+ERR
Sbjct: 1830 EDLVYFEHKSFTKLCKEHDGEFTGEDESSAHALERKSDNPLDIAVTRLADLERNIERR-- 1887
Query: 1603 REPLWPTHEVVLEKALLSTPNGAPEGTTTEISYEITPRIRVWRQTLERCRSAAQVCLCLG 1662
I +I P +RVWR+ L RSAAQV LC+
Sbjct: 1888 ------------------------------IEEDIAPGLRVWRRALSEARSAAQVALCIQ 1917
Query: 1663 QLERSIAWEKSVNKVTCLVCRKGDNDEFLLLCDGCDRGCHIYCHRPKMEAVPEGDWFCTV 1722
QL++SIAWEKS+ KV C +CRKGDN+E LLLCDGCD+GCH YCHRPK+ +P+GDWFC
Sbjct: 1918 QLQKSIAWEKSIMKVYCQICRKGDNEELLLLCDGCDKGCHTYCHRPKITTIPDGDWFCPA 1977
Query: 1723 CLAQQVEGEFTQKPGFPKRGQK---RKSGYSLNFS-----EGDGRRRRVLLRGRESPAAG 1774
C+A + G+ + +G+K K G + + E L RG +
Sbjct: 1978 CIA-KASGQTLKIKKLHVKGKKTNESKKGKKVTLTGDTEDEDSASTSSSLKRGNKDLKKR 2036
Query: 1775 PRYSEEGLSPSKRRRLS-----MRNHHSDLTFCEIILMEMESHDAAWPFLEPVNPRLVSG 1829
++ SK+ + R+ DL C +IL EME+H+ AWPFL PVN +LV G
Sbjct: 2037 KMEENTSINLSKQESFTSVKKPKRDDSKDLALCSMILTEMETHEDAWPFLLPVNLKLVPG 2096
Query: 1830 YRRIIKNPMDFSTMRERLLRGGYTSSEEFAADALLVFDNCQTFNEDDSEVGKAGHIMRRF 1889
Y+++IK PMDFST+RE+L G Y + E FA D LVFDNC+TFNEDDS++G+AGH MR++
Sbjct: 2097 YKKVIKKPMDFSTIREKLSSGQYPNLETFALDVRLVFDNCETFNEDDSDIGRAGHNMRKY 2156
Query: 1890 FESRWEEFYQ 1899
FE +W + ++
Sbjct: 2157 FEKKWTDTFK 2166
>gi|14670392 bromodomain adjacent to zinc finger domain, 1B [Homo
sapiens]
Length = 1483
Score = 117 bits (292), Expect = 1e-25
Identities = 74/285 (25%), Positives = 121/285 (42%), Gaps = 44/285 (15%)
Query: 1636 EITPRIRVWRQTLERCRSAAQVCLCLGQLERSIAWEKSVNKVTCLVCRKGDNDEFLLLCD 1695
++ + W+ + ++ +++ + LG L+ I W+ S C VCRK D+ L+LCD
Sbjct: 1144 KVASALEKWKTAIREAQTFSRMHVLLGMLDACIKWDMSAENARCKVCRKKGEDDKLILCD 1203
Query: 1696 GCDRGCHIYCHRPKMEAVPEGDWFCTVC------------------LAQQVEGEFTQKPG 1737
C++ H++C RP + VP+G+W C C ++ E + + +
Sbjct: 1204 ECNKAFHLFCLRPALYEVPDGEWQCPACQPATARRNSRGRNYTEESASEDSEDDESDEEE 1263
Query: 1738 FPKRGQKRKSGYSLNFSEGDGRRRRVLLRGRES--PAAGPRYSEEGLSPSKRRR------ 1789
+ ++ + Y + G R R +RG+ S P A G P RR
Sbjct: 1264 EEEEEEEEEEDYEV---AGLRLRPRKTIRGKHSVIPPAARSGRRPGKKPHSTRRSQPKAP 1320
Query: 1790 ---------------LSMRNHHSDLTFCEIILMEMESHDAAWPFLEPVNPRLVSGYRRII 1834
S R +L CE IL ++ + +WPF EPV Y +I
Sbjct: 1321 PVDDAEVDELVLQTKRSSRRQSLELQKCEEILHKIVKYRFSWPFREPVTRDEAEDYYDVI 1380
Query: 1835 KNPMDFSTMRERLLRGGYTSSEEFAADALLVFDNCQTFNEDDSEV 1879
+PMDF T++ + G Y S +EF D VF N + +N S V
Sbjct: 1381 THPMDFQTVQNKCSCGSYRSVQEFLTDMKQVFTNAEVYNCRGSHV 1425
Score = 85.5 bits (210), Expect = 5e-16
Identities = 129/554 (23%), Positives = 221/554 (39%), Gaps = 105/554 (18%)
Query: 646 QAITGKRGRPRN---TEKAKTKEVPKVKRGRGRPPKVKITELLN---KTDNRPLKKLEA- 698
Q TG P+ T K K K++ + +G + +T ++P K L
Sbjct: 415 QKSTGNSKSPKKGLKTPKTKMKQMTLLDMAKGTQKMTRAPRNSGGTPRTSSKPHKHLPPA 474
Query: 699 --------QETLNEEDKAKIAKSKKKMRQKVQRGECQTTIQGQARN--KRKQETKSLKQK 748
+E + EDK ++ E + + + R+ +++ E K++
Sbjct: 475 ALHLIAYYKENKDREDKRSALSCVISKTARLLSSEDRARLPEELRSLVQKRYELLEHKKR 534
Query: 749 EAKKKSKAEKEKGKTKQEKLKEKVKREKKEKVKMKEKEEVTKAKPACKADKTLATQRRLE 808
A + KE K K+E+LK+K+K + KE+ +EKE + RLE
Sbjct: 535 WASMSEEQRKEYLKKKREELKKKLKEKAKER---REKEML----------------ERLE 575
Query: 809 ERQRQQMILEEMKKPTEDMCLTDHQPLPDFSRVPGLT-LPSGAFSDCLTIVEFLHSFGKV 867
+++R ED LT + LP F V LP+ F D +VEFL + +
Sbjct: 576 KQKRY-----------EDQELTG-KNLPAFRLVDTPEGLPNTLFGDVAMVVEFLSCYSGL 623
Query: 868 LGFDPAKDVPSLGVLQEGLLCQGDSLGEVQDLLVRLLKAALHDPGFPSYCQSLKILGEKV 927
L D + ++ L E L + +LV LL+ L D Y + LG K+
Sbjct: 624 LLPDAQYPITAVS-LMEALSADKGGFLYLNRVLVILLQTLLQDEIAEDYGE----LGMKL 678
Query: 928 SEIPLTRDNVSEILRCFLMAYG-----------------------VEPALCDRLRTQPFQ 964
SEIPLT +VSE++R L V+ ++L T F
Sbjct: 679 SEIPLTLHSVSELVRLCLRRSDVQEESEGSDTDDNKDSAAFEDNEVQDEFLEKLETSEFF 738
Query: 965 AQPPQQKAAVLAFLVHELNGSTLIINEIDKTLESMSSYRKNKWIVEGRLRRLK----TVL 1020
++K +L L H + L+ + +E+ W + RL LK
Sbjct: 739 ELTSEEKLQILTALCHRI----LMTYSVQDHMETRQQMSAELW--KERLAVLKEENDKKR 792
Query: 1021 AKRTGRSEVEMEGP-----EECLGRRRSSRIMEETSGMEEEEEEESIAAVPGRR-----G 1070
A++ R E+E + E LG+ + + + + E E+ I+AV RR
Sbjct: 793 AEKQKRKEMEAKNKENGKVENGLGKTDRKKEIVKFEPQVDTEAEDMISAVKSRRLLAIQA 852
Query: 1071 RRDGEVDATASSIPELERQIEKLSKR------QLFFRKKLLHSSQMLRAVSLGQDRYRRR 1124
+++ E+ + +LERQ E+ R + F++ + + ++R +G DR R
Sbjct: 853 KKEREIQEREMKV-KLERQAEEERIRKHKAAAEKAFQEGIAKAKLVMRRTPIGTDRNHNR 911
Query: 1125 YWVL-PYLAGIFVE 1137
YW+ + G+F+E
Sbjct: 912 YWLFSDEVPGLFIE 925
Score = 37.7 bits (86), Expect = 0.11
Identities = 19/60 (31%), Positives = 33/60 (55%), Gaps = 2/60 (3%)
Query: 1424 TQLTAQPVPPEMCSGWWWIRDPEM-LDAMLKALHPRGIREKALHKHLNK-HRDFLQEVCL 1481
T++ + P+ W++ D + LD +L LHP+GIRE L + L K ++D + + L
Sbjct: 975 TEVAVETTTPKQGQNLWFLCDSQKELDELLNCLHPQGIRESQLKERLEKRYQDIIHSIHL 1034
>gi|32967605 bromodomain adjacent to zinc finger domain, 1A isoform b
[Homo sapiens]
Length = 1524
Score = 116 bits (290), Expect = 2e-25
Identities = 109/428 (25%), Positives = 172/428 (40%), Gaps = 90/428 (21%)
Query: 1395 PQSPTGLGQPKRRGRPPSKFFKQMEQRYLTQLTAQPVPPEMCSGWWWIRDPEMLDAMLKA 1454
PQ T G+P S+ ++Q P P + W + E LD +++A
Sbjct: 821 PQVSTKTGEPLM-----SESTSNIDQGPRDHSVQLPKPVHKPNRWCFYSSCEQLDQLIEA 875
Query: 1455 LHPRGIREKALHKHLNKHRDFLQEVCLRPSADPIF-----EPRQLPAFQEGIMS--WSPK 1507
L+ RG RE AL + L + + + R S + +P P + G S + P
Sbjct: 876 LNSRGHRESALKETLLQEKSRICAQLARFSEEKFHFSDKPQPDSKPTYSRGRSSNAYDPS 935
Query: 1508 EKTYET--DLAVLQWVEELEQRVIMSDLQI-----RGWTCPSPDSTREDLAYCEHLS--- 1557
+ E +L + ++ ++E R+ L R + +S R +L E+
Sbjct: 936 QMCAEKQLELRLRDFLLDIEDRIYQGTLGAIKVTDRHIWRSALESGRYELLSEENKENGI 995
Query: 1558 -------------DSQEDITWRGR--GREGLAPQRKTTNP---------LDLAVMRLAAL 1593
D Q + + R G + P +TN + M L +
Sbjct: 996 IKTVNEDVEEMEIDEQTKVIVKDRLLGIKTETPSTVSTNASTPQSVSSVVHYLAMALFQI 1055
Query: 1594 EQNVERRYLREPLWPTHEVVLEKALLSTPNGAPEGTTTEISYEITPRIRVWRQTLERCRS 1653
EQ +ERR+L+ PL + + + SY+ + WR++L S
Sbjct: 1056 EQGIERRFLKAPL--------------------DASDSGRSYKTV--LDRWRESLLSSAS 1093
Query: 1654 AAQVCLCLGQLERSIAWEKSVNKVTCLVCRKGDNDEFLLLCDGCDRGCHIYCHRPKMEAV 1713
+QV L L L+RS+ W KS+ C +CRK + E ++LCDGCDRG H YC RPK++ V
Sbjct: 1094 LSQVFLHLSTLDRSVIWSKSILNARCKICRKKGDAENMVLCDGCDRGHHTYCVRPKLKTV 1153
Query: 1714 PEGDWFCTVCLAQQ----------------------VEGEFTQKPGFPKRGQKRKSGYSL 1751
PEGDWFC C +Q + GE + G + GQ + Y +
Sbjct: 1154 PEGDWFCPECRPKQRSRRLSSRQRPSLESDEDVEDSMGGEDDEVDGDEEEGQSEEEEYEV 1213
Query: 1752 NFSEGDGR 1759
E D +
Sbjct: 1214 EQDEDDSQ 1221
Score = 100 bits (250), Expect = 1e-20
Identities = 130/562 (23%), Positives = 231/562 (41%), Gaps = 104/562 (18%)
Query: 677 PKVKITELLNKTDNRPLKKLEAQETLNEEDKAKIAKSKKKMRQKVQRGECQTTIQGQARN 736
P I N+ RP K++ + N +K +A + K ++ + Q ++ A
Sbjct: 264 PPTFIFSPANRRRGRPPKRIHISQEDNVANKQTLASYRSKATKERDKLLKQEEMKSLAFE 323
Query: 737 KRKQETKSLKQKEAKKKSKAEKEKGKTKQEKLKEKVKREKKEKVKMKEKEEVTKAKPACK 796
K K + + EAKKK K +KEK K+E+LK+ V+ E+ +K + KE+ +V + K
Sbjct: 324 KAKLKREKADALEAKKKEKEDKEK---KREELKKIVEEERLKKKEEKERLKVEREKER-- 378
Query: 797 ADKTLATQRRLEERQRQQMILEEMKKPTEDMCLTDHQPLPDFSRVPGLTLPSGAFSDCLT 856
++ EE+++ L++ KP EDM D + LP+ + V LP F D L
Sbjct: 379 -------EKLREEKRKYVEYLKQWSKPREDMECDDLKELPEPTPVK-TRLPPEIFGDALM 430
Query: 857 IVEFLHSFGKVLGF-DPAKDVPSLGVLQEGLLCQGDSLGEVQDLLVRLLKAAL------H 909
++EFL++FG++ D D +L VL+E L+ DS G + +LL L A
Sbjct: 431 VLEFLNAFGELFDLQDEFPDGVTLEVLEEALV-GNDSEGPLCELLFFFLTAIFQAIAEEE 489
Query: 910 DPGFPSYCQSLKILGEKVSEIPLTRDNVSEILRCFLMAYGVE------------------ 951
+ G + + L +SEILR ++A G +
Sbjct: 490 EEVAKEQLTDADTKGCSLKSLDLDSCTLSEILRLHILASGADVTSANAKYRYQKRGGFDA 549
Query: 952 ------------PALCDRLRTQPFQAQPPQQKAAVLAFLVHEL----NGSTLIINEIDKT 995
P+L +L + P +K +L L +L + I + +D
Sbjct: 550 TDDACMELRLSNPSLVKKLSSTSVYDLTPGEKMKILHALCGKLLTLVSTRDFIEDYVDIL 609
Query: 996 LESMSSYRKNKWIVEGRLRRLKTVLAKRTGRSEVEMEGPEECLGRRRSSRIMEE------ 1049
++ +R+ K E + + A+ R E +++ E+ + + + ++ E+
Sbjct: 610 RQAKQEFRELK--AEQHRKEREEAAARIRKRKEEKLKEQEQKM-KEKQEKLKEDEQRNST 666
Query: 1050 ---TSGMEE------------------------EEEEESIAAVPGRRGRR--DGEVDAT- 1079
+ G EE E+E++ + GRRG+R +G + T
Sbjct: 667 ADISIGEEEREDFDTSIESKDTEQKELDQDMVTEDEDDPGSHKRGRRGKRGQNGFKEFTR 726
Query: 1080 ------ASSIPELERQIEKLSKRQLFFRKKLLHSSQMLRAVS----LGQDRYRRRYWVLP 1129
+ P + E L + K+LL Q A + LG+DR RRYW+ P
Sbjct: 727 QEQINCVTREPLTADEEEALKQEHQRKEKELLEKIQSAIACTNIFPLGRDRMYRRYWIFP 786
Query: 1130 YLAGIFVEGTEGNLVPEEVIKK 1151
+ G+F+E L + ++ +
Sbjct: 787 SIPGLFIEEDYSGLTEDMLLPR 808
Score = 66.6 bits (161), Expect = 2e-10
Identities = 43/140 (30%), Positives = 70/140 (50%), Gaps = 10/140 (7%)
Query: 1751 LNFSEGDGRRRRVLLRGRESPAAGPRYSEEGLSPSKRRRLSMRNHHSDLTFCEIILMEME 1810
L+ E + +RR R R+SP P RR + +L+ E +++E+
Sbjct: 1365 LSLQESESKRR---CRKRQSPEPSP-------VTLGRRSSGRQGGVHELSAFEQLVVELV 1414
Query: 1811 SHDAAWPFLEPVNPRLVSGYRRIIKNPMDFSTMRERLLRGGYTSSEEFAADALLVFDNCQ 1870
HD +WPFL+ V+ V Y IIK P+ + +RE++ + Y + EF D L+F NC
Sbjct: 1415 RHDDSWPFLKLVSKIQVPDYYDIIKKPIALNIIREKVNKCEYKLASEFIDDIELMFSNCF 1474
Query: 1871 TFNEDDSEVGKAGHIMRRFF 1890
+N ++ KAG ++ FF
Sbjct: 1475 EYNPRNTSEAKAGTRLQAFF 1494
>gi|32967603 bromodomain adjacent to zinc finger domain, 1A isoform a
[Homo sapiens]
Length = 1556
Score = 116 bits (290), Expect = 2e-25
Identities = 109/428 (25%), Positives = 172/428 (40%), Gaps = 90/428 (21%)
Query: 1395 PQSPTGLGQPKRRGRPPSKFFKQMEQRYLTQLTAQPVPPEMCSGWWWIRDPEMLDAMLKA 1454
PQ T G+P S+ ++Q P P + W + E LD +++A
Sbjct: 853 PQVSTKTGEPLM-----SESTSNIDQGPRDHSVQLPKPVHKPNRWCFYSSCEQLDQLIEA 907
Query: 1455 LHPRGIREKALHKHLNKHRDFLQEVCLRPSADPIF-----EPRQLPAFQEGIMS--WSPK 1507
L+ RG RE AL + L + + + R S + +P P + G S + P
Sbjct: 908 LNSRGHRESALKETLLQEKSRICAQLARFSEEKFHFSDKPQPDSKPTYSRGRSSNAYDPS 967
Query: 1508 EKTYET--DLAVLQWVEELEQRVIMSDLQI-----RGWTCPSPDSTREDLAYCEHLS--- 1557
+ E +L + ++ ++E R+ L R + +S R +L E+
Sbjct: 968 QMCAEKQLELRLRDFLLDIEDRIYQGTLGAIKVTDRHIWRSALESGRYELLSEENKENGI 1027
Query: 1558 -------------DSQEDITWRGR--GREGLAPQRKTTNP---------LDLAVMRLAAL 1593
D Q + + R G + P +TN + M L +
Sbjct: 1028 IKTVNEDVEEMEIDEQTKVIVKDRLLGIKTETPSTVSTNASTPQSVSSVVHYLAMALFQI 1087
Query: 1594 EQNVERRYLREPLWPTHEVVLEKALLSTPNGAPEGTTTEISYEITPRIRVWRQTLERCRS 1653
EQ +ERR+L+ PL + + + SY+ + WR++L S
Sbjct: 1088 EQGIERRFLKAPL--------------------DASDSGRSYKTV--LDRWRESLLSSAS 1125
Query: 1654 AAQVCLCLGQLERSIAWEKSVNKVTCLVCRKGDNDEFLLLCDGCDRGCHIYCHRPKMEAV 1713
+QV L L L+RS+ W KS+ C +CRK + E ++LCDGCDRG H YC RPK++ V
Sbjct: 1126 LSQVFLHLSTLDRSVIWSKSILNARCKICRKKGDAENMVLCDGCDRGHHTYCVRPKLKTV 1185
Query: 1714 PEGDWFCTVCLAQQ----------------------VEGEFTQKPGFPKRGQKRKSGYSL 1751
PEGDWFC C +Q + GE + G + GQ + Y +
Sbjct: 1186 PEGDWFCPECRPKQRSRRLSSRQRPSLESDEDVEDSMGGEDDEVDGDEEEGQSEEEEYEV 1245
Query: 1752 NFSEGDGR 1759
E D +
Sbjct: 1246 EQDEDDSQ 1253
Score = 85.1 bits (209), Expect = 6e-16
Identities = 70/231 (30%), Positives = 116/231 (50%), Gaps = 15/231 (6%)
Query: 677 PKVKITELLNKTDNRPLKKLEAQETLNEEDKAKIAKSKKKMRQKVQRGECQTTIQGQARN 736
P I N+ RP K++ + N +K +A + K ++ + Q ++ A
Sbjct: 264 PPTFIFSPANRRRGRPPKRIHISQEDNVANKQTLASYRSKATKERDKLLKQEEMKSLAFE 323
Query: 737 KRKQETKSLKQKEAKKKSKAEKEKGKTKQEKLKEKVKREKKEKVKMKEKEEVTKAKPACK 796
K K + + EAKKK K +KEK K+E+LK+ V+ E+ +K + KE+ +V + K
Sbjct: 324 KAKLKREKADALEAKKKEKEDKEK---KREELKKIVEEERLKKKEEKERLKVEREKER-- 378
Query: 797 ADKTLATQRRLEERQRQQMILEEMKKPTEDMCLTDHQPLPDFSRVPGLTLPSGAFSDCLT 856
++ EE+++ L++ KP EDM D + LP+ + V LP F D L
Sbjct: 379 -------EKLREEKRKYVEYLKQWSKPREDMECDDLKELPEPTPVK-TRLPPEIFGDALM 430
Query: 857 IVEFLHSFGKVLGF-DPAKDVPSLGVLQEGLLCQGDSLGEVQDLLVRLLKA 906
++EFL++FG++ D D +L VL+E L+ DS G + +LL L A
Sbjct: 431 VLEFLNAFGELFDLQDEFPDGVTLEVLEEALV-GNDSEGPLCELLFFFLTA 480
Score = 66.6 bits (161), Expect = 2e-10
Identities = 43/140 (30%), Positives = 70/140 (50%), Gaps = 10/140 (7%)
Query: 1751 LNFSEGDGRRRRVLLRGRESPAAGPRYSEEGLSPSKRRRLSMRNHHSDLTFCEIILMEME 1810
L+ E + +RR R R+SP P RR + +L+ E +++E+
Sbjct: 1397 LSLQESESKRR---CRKRQSPEPSP-------VTLGRRSSGRQGGVHELSAFEQLVVELV 1446
Query: 1811 SHDAAWPFLEPVNPRLVSGYRRIIKNPMDFSTMRERLLRGGYTSSEEFAADALLVFDNCQ 1870
HD +WPFL+ V+ V Y IIK P+ + +RE++ + Y + EF D L+F NC
Sbjct: 1447 RHDDSWPFLKLVSKIQVPDYYDIIKKPIALNIIREKVNKCEYKLASEFIDDIELMFSNCF 1506
Query: 1871 TFNEDDSEVGKAGHIMRRFF 1890
+N ++ KAG ++ FF
Sbjct: 1507 EYNPRNTSEAKAGTRLQAFF 1526
Score = 39.7 bits (91), Expect = 0.028
Identities = 31/112 (27%), Positives = 52/112 (46%), Gaps = 13/112 (11%)
Query: 1053 MEEEEEEESIAAVPGRRGRR--DGEVDAT-------ASSIPELERQIEKLSKRQLFFRKK 1103
M E+E++ + GRRG+R +G + T + P + E L + K+
Sbjct: 729 MVTEDEDDPGSHKRGRRGKRGQNGFKEFTRQEQINCVTREPLTADEEEALKQEHQRKEKE 788
Query: 1104 LLHSSQMLRAVS----LGQDRYRRRYWVLPYLAGIFVEGTEGNLVPEEVIKK 1151
LL Q A + LG+DR RRYW+ P + G+F+E L + ++ +
Sbjct: 789 LLEKIQSAIACTNIFPLGRDRMYRRYWIFPSIPGLFIEEDYSGLTEDMLLPR 840
Score = 37.7 bits (86), Expect = 0.11
Identities = 27/94 (28%), Positives = 49/94 (52%), Gaps = 6/94 (6%)
Query: 739 KQETKSLK-QKEAKKKSKAEKEKGKTKQEKLKEKVKREKKEKVKMKEKEEVTKAKPACKA 797
KQE + LK ++ K++ +A K K+EKLKE+ ++ K+++ K+KE E+ A
Sbjct: 645 KQEFRELKAEQHRKEREEAAARIRKRKEEKLKEQEQKMKEKQEKLKEDEQRNST-----A 699
Query: 798 DKTLATQRRLEERQRQQMILEEMKKPTEDMCLTD 831
D ++ + R + + E K+ +DM D
Sbjct: 700 DISIGEEEREDFDTSIESKDTEQKELDQDMVTED 733
Score = 37.7 bits (86), Expect = 0.11
Identities = 22/94 (23%), Positives = 46/94 (48%), Gaps = 7/94 (7%)
Query: 730 IQGQARNKRKQETKSLKQKEAKKKSKAEKEKGKTKQEKLKEKVKREKKEKVKMKEKEEVT 789
++ + K ++E + +K ++K K +++K K KQEKLKE +R + + E+E
Sbjct: 651 LKAEQHRKEREEAAARIRKRKEEKLKEQEQKMKEKQEKLKEDEQRNSTADISIGEEERE- 709
Query: 790 KAKPACKADKTLATQRRLEERQRQQMILEEMKKP 823
D ++ ++ ++ Q M+ E+ P
Sbjct: 710 ------DFDTSIESKDTEQKELDQDMVTEDEDDP 737
>gi|74027251 tripartite motif-containing 33 protein isoform beta [Homo
sapiens]
Length = 1110
Score = 103 bits (258), Expect = 1e-21
Identities = 70/230 (30%), Positives = 108/230 (46%), Gaps = 51/230 (22%)
Query: 1675 NKVTCLVCRKGDNDEFLLLCDGCDRGCHIYCHRPKMEAVPEGDWFCTVCLAQQVEGEFTQ 1734
N+ C VC+ G + LL C+ C + H+ CH P + + P GDW CT C +
Sbjct: 886 NEDWCAVCQNGGD---LLCCEKCPKVFHLTCHVPTLLSFPSGDWICTFC----------R 932
Query: 1735 KPGFPKRGQKRKSGYSLNFSEGDGRRRRVLLRGRESPAAGPRYSEEGLSPSKRRRLSMRN 1794
G P+ E D + +G+ + +GLSP +R+
Sbjct: 933 DIGKPE-------------VEYDCDNLQHSKKGKTA---------QGLSPVDQRK----- 965
Query: 1795 HHSDLTFCEIILMEMESHDAAWPFLEPVNPRLVSGYRRIIKNPMDFSTMRERLLRGG--- 1851
CE +L+ + H+ + F EPV P + Y +IIK PMD ST++++L +
Sbjct: 966 -------CERLLLYLYCHELSIEFQEPV-PASIPNYYKIIKKPMDLSTVKKKLQKKHSQH 1017
Query: 1852 YTSSEEFAADALLVFDNCQTFNEDDSEVGKAGHIMRRFFESRWEEFYQGK 1901
Y ++F AD L+F NC+ FNE DSEV +AG + +FE + E Y +
Sbjct: 1018 YQIPDDFVADVRLIFKNCERFNEADSEVAQAGKAVALYFEDKLTEIYSDR 1067
>gi|47419911 transcriptional intermediary factor 1 alpha isoform a
[Homo sapiens]
Length = 1050
Score = 101 bits (252), Expect = 6e-21
Identities = 72/234 (30%), Positives = 105/234 (44%), Gaps = 47/234 (20%)
Query: 1671 EKSVNKVTCLVCRKGDNDEFLLLCDGCDRGCHIYCHRPKMEAVPEGDWFCTVCLAQQVEG 1730
E N+ C VC+ G LL C+ C + H+ CH P + P G+W CT C +
Sbjct: 821 EDDPNEDWCAVCQNGGE---LLCCEKCPKVFHLSCHVPTLTNFPSGEWICTFC-RDLSKP 876
Query: 1731 EFTQKPGFPKRGQKRKSGYSLNFSEGDGRRRRVLLRGRESPAAGPRYSEEGLSPSKRRRL 1790
E P ++K +EG L++ L+P +R+
Sbjct: 877 EVEYDCDAPSHNSEKKK------TEG-------LVK---------------LTPIDKRK- 907
Query: 1791 SMRNHHSDLTFCEIILMEMESHDAAWPFLEPVNPRLVSGYRRIIKNPMDFSTMRERLLR- 1849
CE +L+ + H+ + F +PV P V Y +IIKNPMD ST+++RL
Sbjct: 908 -----------CERLLLFLYCHEMSLAFQDPV-PLTVPDYYKIIKNPMDLSTIKKRLQED 955
Query: 1850 -GGYTSSEEFAADALLVFDNCQTFNEDDSEVGKAGHIMRRFFESRWEEFYQGKQ 1902
Y+ E+F AD L+F NC FNE DSEV AG + +FE + Y K+
Sbjct: 956 YSMYSKPEDFVADFRLIFQNCAEFNEPDSEVANAGIKLENYFEELLKNLYPEKR 1009
>gi|47419909 transcriptional intermediary factor 1 alpha isoform b
[Homo sapiens]
Length = 1016
Score = 101 bits (252), Expect = 6e-21
Identities = 72/234 (30%), Positives = 105/234 (44%), Gaps = 47/234 (20%)
Query: 1671 EKSVNKVTCLVCRKGDNDEFLLLCDGCDRGCHIYCHRPKMEAVPEGDWFCTVCLAQQVEG 1730
E N+ C VC+ G LL C+ C + H+ CH P + P G+W CT C +
Sbjct: 787 EDDPNEDWCAVCQNGGE---LLCCEKCPKVFHLSCHVPTLTNFPSGEWICTFC-RDLSKP 842
Query: 1731 EFTQKPGFPKRGQKRKSGYSLNFSEGDGRRRRVLLRGRESPAAGPRYSEEGLSPSKRRRL 1790
E P ++K +EG L++ L+P +R+
Sbjct: 843 EVEYDCDAPSHNSEKKK------TEG-------LVK---------------LTPIDKRK- 873
Query: 1791 SMRNHHSDLTFCEIILMEMESHDAAWPFLEPVNPRLVSGYRRIIKNPMDFSTMRERLLR- 1849
CE +L+ + H+ + F +PV P V Y +IIKNPMD ST+++RL
Sbjct: 874 -----------CERLLLFLYCHEMSLAFQDPV-PLTVPDYYKIIKNPMDLSTIKKRLQED 921
Query: 1850 -GGYTSSEEFAADALLVFDNCQTFNEDDSEVGKAGHIMRRFFESRWEEFYQGKQ 1902
Y+ E+F AD L+F NC FNE DSEV AG + +FE + Y K+
Sbjct: 922 YSMYSKPEDFVADFRLIFQNCAEFNEPDSEVANAGIKLENYFEELLKNLYPEKR 975
>gi|209977097 tripartite motif-containing 66 [Homo sapiens]
Length = 1216
Score = 96.7 bits (239), Expect = 2e-19
Identities = 70/231 (30%), Positives = 101/231 (43%), Gaps = 50/231 (21%)
Query: 1675 NKVTCLVCRKGDNDEFLLLCDGCDRGCHIYCHRPKMEAVPEGDWFCTVCLAQQVEGEFTQ 1734
N+ C VC G LL CD C + H+ CH P + + P G+W CT+C
Sbjct: 969 NEDFCAVCLNGGE---LLCCDRCPKVFHLSCHVPALLSFPGGEWVCTLC----------- 1014
Query: 1735 KPGFPKRGQKRKSGYSLNFSEGDGRRRRVLLRGRESPAAGPRYSEEGLSPSKRRRLSMRN 1794
R + E Y++ G+ S LSM +
Sbjct: 1015 --------------------------RSLTQPEMEYDCENACYNQPGMRASPG--LSMYD 1046
Query: 1795 HHSDLTFCEIILMEMESHDAAWPFLEPVNPRLVSGYRRIIKNPMDFSTMRERLLR---GG 1851
CE +++ + ++ + PF EPV+P L Y +IIK PMD S +R +L +
Sbjct: 1047 QKK----CEKLVLSLCCNNLSLPFHEPVSP-LARHYYQIIKRPMDLSIIRRKLQKKDPAH 1101
Query: 1852 YTSSEEFAADALLVFDNCQTFNEDDSEVGKAGHIMRRFFESRWEEFYQGKQ 1902
YT+ EE +D L+F NC FN DSEV +AG + FFE +E Y K+
Sbjct: 1102 YTTPEEVVSDVRLMFWNCAKFNYPDSEVAEAGRCLEVFFEGWLKEIYPEKR 1152
Score = 31.6 bits (70), Expect = 7.7
Identities = 58/230 (25%), Positives = 82/230 (35%), Gaps = 43/230 (18%)
Query: 1152 ETDSLKVAAHASLNPALFSMKMELAGSNTTASSPARARGRPRKTKPGSMQPRH-LKSPV- 1209
+ ++L +H +PA+ S + S+ + SP+ P P S+ P H + P
Sbjct: 299 QQEALSHPSHKFQSPAVCSSSV--CCSHCSPVSPSLKGQVP----PPSIHPAHSFRQPPE 352
Query: 1210 ---RGQDSEQPQAQLQPEAQLHAPAQPQPQLQLQLQSHKGFLEQEGSPLSLGQS------ 1260
+ S Q A L E +L P LQ L++ +EQE + LGQ
Sbjct: 353 MVPQQLGSLQCSALLPREKELACSPHPPKLLQPWLETQPP-VEQESTSQRLGQQLTSQPV 411
Query: 1261 ----QHDLSQSAFLSWLSQTQSHSSLLSSSVLTPDSSPGKLDPAPSQPPEEPEPDEAESS 1316
D+ Q A QT S V KL QP ++ P
Sbjct: 412 CIVPPQDVQQGAHAQPTLQTPS------IQVQFGHHQKLKLSHFQQQPQQQLPPP----- 460
Query: 1317 PDPQALWFNISAQMPCNAAPTPPPAVSEDQPTPSPQQLASSKPMNRPSAA 1366
P P +P P PPP P P Q LASS+ + P A
Sbjct: 461 PPP----------LPHPPPPLPPPPQQPHPPLPPSQHLASSQHESPPGPA 500
>gi|74027249 tripartite motif-containing 33 protein isoform alpha
[Homo sapiens]
Length = 1127
Score = 93.2 bits (230), Expect = 2e-18
Identities = 70/247 (28%), Positives = 108/247 (43%), Gaps = 68/247 (27%)
Query: 1675 NKVTCLVCRKGDNDEFLLLCDGCDRGCHIYCHRPKMEAVPEGDWFCTVCLAQQVEGEFTQ 1734
N+ C VC+ G + LL C+ C + H+ CH P + + P GDW CT C +
Sbjct: 886 NEDWCAVCQNGGD---LLCCEKCPKVFHLTCHVPTLLSFPSGDWICTFC----------R 932
Query: 1735 KPGFPKRGQKRKSGYSLNFSEGDGRRRRVLLRGRESPAAGPRYSEEGLSPSKRRRLSMRN 1794
G P+ E D + +G+ + +GLSP +R+
Sbjct: 933 DIGKPE-------------VEYDCDNLQHSKKGKTA---------QGLSPVDQRK----- 965
Query: 1795 HHSDLTFCEIILMEMESHDAAWPFLEPVNPRLVSGYRRIIKNPMDFSTMRERLLRGG--- 1851
CE +L+ + H+ + F EPV P + Y +IIK PMD ST++++L +
Sbjct: 966 -------CERLLLYLYCHELSIEFQEPV-PASIPNYYKIIKKPMDLSTVKKKLQKKHSQH 1017
Query: 1852 YTSSEEFAADALLVFDNCQTFNE-----------------DDSEVGKAGHIMRRFFESRW 1894
Y ++F AD L+F NC+ FNE DSEV +AG + +FE +
Sbjct: 1018 YQIPDDFVADVRLIFKNCERFNEMMKVVQVYADTQEINLKADSEVAQAGKAVALYFEDKL 1077
Query: 1895 EEFYQGK 1901
E Y +
Sbjct: 1078 TEIYSDR 1084
>gi|40805843 K(lysine) acetyltransferase 2B [Homo sapiens]
Length = 832
Score = 85.9 bits (211), Expect = 3e-16
Identities = 47/123 (38%), Positives = 67/123 (54%), Gaps = 1/123 (0%)
Query: 1775 PRYSEEGLSPS-KRRRLSMRNHHSDLTFCEIILMEMESHDAAWPFLEPVNPRLVSGYRRI 1833
P E G PS K + R+ + + IL +++SH +AWPF+EPV GY +
Sbjct: 704 PGIRETGWKPSGKEKSKEPRDPDQLYSTLKSILQQVKSHQSAWPFMEPVKRTEAPGYYEV 763
Query: 1834 IKNPMDFSTMRERLLRGGYTSSEEFAADALLVFDNCQTFNEDDSEVGKAGHIMRRFFESR 1893
I+ PMD TM ERL Y S + F AD VF NC+ +N +SE K +I+ +FF S+
Sbjct: 764 IRFPMDLKTMSERLKNRYYVSKKLFMADLQRVFTNCKEYNPPESEYYKCANILEKFFFSK 823
Query: 1894 WEE 1896
+E
Sbjct: 824 IKE 826
>gi|38788260 bromodomain PHD finger transcription factor isoform 2
[Homo sapiens]
Length = 2903
Score = 83.6 bits (205), Expect = 2e-15
Identities = 38/100 (38%), Positives = 55/100 (55%)
Query: 1805 ILMEMESHDAAWPFLEPVNPRLVSGYRRIIKNPMDFSTMRERLLRGGYTSSEEFAADALL 1864
+L +++H AWPFLEPV+P Y +IK PMD +TM ER+ R Y EF AD
Sbjct: 2796 VLRSLQAHKMAWPFLEPVDPNDAPDYYGVIKEPMDLATMEERVQRRYYEKLTEFVADMTK 2855
Query: 1865 VFDNCQTFNEDDSEVGKAGHIMRRFFESRWEEFYQGKQAN 1904
+FDNC+ +N DS + ++ FF + + F + N
Sbjct: 2856 IFDNCRYYNPSDSPFYQCAEVLESFFVQKLKGFKASRSHN 2895
Score = 50.1 bits (118), Expect = 2e-05
Identities = 24/53 (45%), Positives = 31/53 (58%), Gaps = 5/53 (9%)
Query: 1679 CLVCRK-GDNDEFLLLCDGCDRGCHIYCHRPKMEAVPEGDWFCTVCLAQQVEG 1730
C VC K GD LL C+ C H+ C +P +E VPE +W C VC+A +V G
Sbjct: 393 CRVCHKLGD----LLCCETCSAVYHLECVKPPLEEVPEDEWQCEVCVAHKVPG 441
Score = 47.4 bits (111), Expect = 1e-04
Identities = 69/302 (22%), Positives = 121/302 (40%), Gaps = 35/302 (11%)
Query: 1061 SIAAVPGRRGRRDG----EVDATASSIPELERQIEKLSKRQLFFRKKLLHSSQMLRAVSL 1116
++++ PG++ + ++AS P ++ KL+ QL + +Q L V
Sbjct: 2237 TVSSTPGQKSLTSATSTSNIQSSASQPPRPQQGQVKLTMAQLTQLTQGHGGNQGLTVVIQ 2296
Query: 1117 GQDRYRRRYWVLPYLAGIFVEGTEGNLVPEEVIKKETDSLKVAAHASLNPALFSMKMELA 1176
GQ + + ++P G+ V G + + + T L L + +
Sbjct: 2297 GQGQTTGQLQLIPQ--GVTVLPGPGQQLMQAAMPNGT------VQRFLFTPLATTATTAS 2348
Query: 1177 GSNTTASSPARARGRPRKTKPGSMQPRHLKS-----------PVRGQ-DSEQPQAQLQPE 1224
+ TT S+ A G R++K H P Q + QP AQ QP+
Sbjct: 2349 TTTTTVSTTAAGTGEQRQSKLSPQMQVHQDKTLPPAQSSSVGPAEAQPQTAQPSAQPQPQ 2408
Query: 1225 AQLHAPAQPQPQLQLQLQSHKGFLEQEGSPLSLGQSQHDLSQSAFLSWLSQTQSHSSLLS 1284
Q +PAQP+ Q Q ++Q+ S ++Q +QS+ +Q+Q S++
Sbjct: 2409 TQPQSPAQPEVQTQPEVQTQTTVSSHVPS-----EAQPTHAQSSKPQVAAQSQPQSNVQG 2463
Query: 1285 SS-VLTPDSSPGKLDPA-PSQ--PPEEPEPDEAESSPDPQALWFNISAQMPCNAAPTPPP 1340
S V S ++ P+ PSQ P ++ + S P P + + S Q+P P P
Sbjct: 2464 QSPVRVQSPSQTRIRPSTPSQLSPGQQSQVQTTTSQPIP--IQPHTSLQIPSQGQPQSQP 2521
Query: 1341 AV 1342
V
Sbjct: 2522 QV 2523
Score = 32.0 bits (71), Expect = 5.9
Identities = 31/127 (24%), Positives = 54/127 (42%), Gaps = 16/127 (12%)
Query: 681 ITELLNKTDNRPLKK--LEAQETLNEEDKAKIAKSKKKMRQKVQRGECQTTIQGQARNKR 738
+ ELL+ ++P K+ +E + + E +S + V G R
Sbjct: 1125 VKELLDSDSDKPCKEEPMEVDDDMKTESHVNCQESSQVDVVNVSEGF-------HLRTSY 1177
Query: 739 KQETKSLKQK---EAKKKSKAEKEKGKTKQEKLKEKVKREKKEKVK----MKEKEEVTKA 791
K++TKS K E + K +EK + ++ KL+ +K K + E +TKA
Sbjct: 1178 KKKTKSSKLDGLLERRIKQFTLEEKQRLEKIKLEGGIKGIGKTSTNSSKNLSESPVITKA 1237
Query: 792 KPACKAD 798
K C++D
Sbjct: 1238 KEGCQSD 1244
>gi|38788274 bromodomain PHD finger transcription factor isoform 1
[Homo sapiens]
Length = 2920
Score = 83.6 bits (205), Expect = 2e-15
Identities = 38/100 (38%), Positives = 55/100 (55%)
Query: 1805 ILMEMESHDAAWPFLEPVNPRLVSGYRRIIKNPMDFSTMRERLLRGGYTSSEEFAADALL 1864
+L +++H AWPFLEPV+P Y +IK PMD +TM ER+ R Y EF AD
Sbjct: 2813 VLRSLQAHKMAWPFLEPVDPNDAPDYYGVIKEPMDLATMEERVQRRYYEKLTEFVADMTK 2872
Query: 1865 VFDNCQTFNEDDSEVGKAGHIMRRFFESRWEEFYQGKQAN 1904
+FDNC+ +N DS + ++ FF + + F + N
Sbjct: 2873 IFDNCRYYNPSDSPFYQCAEVLESFFVQKLKGFKASRSHN 2912
Score = 55.8 bits (133), Expect = 4e-07
Identities = 76/331 (22%), Positives = 135/331 (40%), Gaps = 40/331 (12%)
Query: 1061 SIAAVPGRRGRRDG----EVDATASSIPELERQIEKLSKRQLFFRKKLLHSSQMLRAVSL 1116
++++ PG++ + ++AS P ++ KL+ QL + +Q L V
Sbjct: 2111 TVSSTPGQKSLTSATSTSNIQSSASQPPRPQQGQVKLTMAQLTQLTQGHGGNQGLTVVIQ 2170
Query: 1117 GQDRYRRRYWVLPYLAGIFVEGTEGNLVPEEVIKKETDSLKVAAHASLNPALFSMKMELA 1176
GQ + + ++P G+ V G + + + T L L + +
Sbjct: 2171 GQGQTTGQLQLIPQ--GVTVLPGPGQQLMQAAMPNGT------VQRFLFTPLATTATTAS 2222
Query: 1177 GSNTTASSPARARGRPRKTKPGSMQPRHLKS-----------PVRGQ-DSEQPQAQLQPE 1224
+ TT S+ A G R++K H P Q + QP AQ QP+
Sbjct: 2223 TTTTTVSTTAAGTGEQRQSKLSPQMQVHQDKTLPPAQSSSVGPAEAQPQTAQPSAQPQPQ 2282
Query: 1225 AQLHAPAQPQPQLQLQLQSHKGFLEQEGSPLSLGQSQHDLSQSAFLSWLSQTQSHSSLLS 1284
Q +PAQP+ Q Q ++Q+ S ++Q +QS+ +Q+Q S++
Sbjct: 2283 TQPQSPAQPEVQTQPEVQTQTTVSSHVPS-----EAQPTHAQSSKPQVAAQSQPQSNVQG 2337
Query: 1285 SS-VLTPDSSPGKLDPA-PSQ--PPEEPEPDEAESSPDPQALWFNISAQMPCNAAPTPPP 1340
S V S ++ P+ PSQ P ++ + S P P + + S Q+P P P
Sbjct: 2338 QSPVRVQSPSQTRIRPSTPSQLSPGQQSQVQTTTSQPIP--IQPHTSLQIPSQGQPQSQP 2395
Query: 1341 AVSEDQPTPSPQQLASSKPMNRPSAANPCSP 1371
V S Q L+S + +N+ + ++P P
Sbjct: 2396 QVQS-----STQTLSSGQTLNQVTVSSPSRP 2421
Score = 50.1 bits (118), Expect = 2e-05
Identities = 24/53 (45%), Positives = 31/53 (58%), Gaps = 5/53 (9%)
Query: 1679 CLVCRK-GDNDEFLLLCDGCDRGCHIYCHRPKMEAVPEGDWFCTVCLAQQVEG 1730
C VC K GD LL C+ C H+ C +P +E VPE +W C VC+A +V G
Sbjct: 393 CRVCHKLGD----LLCCETCSAVYHLECVKPPLEEVPEDEWQCEVCVAHKVPG 441
Score = 35.0 bits (79), Expect = 0.70
Identities = 29/130 (22%), Positives = 60/130 (46%), Gaps = 11/130 (8%)
Query: 699 QETLNEEDKAKIAKSKKKMRQKVQRGECQTTIQGQARNKRKQETKSLKQKEAKKKSKAEK 758
Q+ +++ K K + + K +Q IQ Q K + LKQK K + AE+
Sbjct: 2505 QQLRDQQQKKKQQQIEIKREHTLQASNQSEIIQKQVVMKHNAVIEHLKQK--KSMTPAER 2562
Query: 759 EKGKTK------QEKLKEKVKREKKEKVKMKEKEEVTKAKPACKADKTLATQRRLEERQR 812
E+ + + + +K+ +E+K+ K +++EE + K ++ + L + +
Sbjct: 2563 EENQRMIVCNQVMKYILDKIDKEEKQAAKKRKREESVEQK---RSKQNATKLSALLFKHK 2619
Query: 813 QQMILEEMKK 822
+Q+ E +KK
Sbjct: 2620 EQLRAEILKK 2629
Score = 32.0 bits (71), Expect = 5.9
Identities = 31/127 (24%), Positives = 54/127 (42%), Gaps = 16/127 (12%)
Query: 681 ITELLNKTDNRPLKK--LEAQETLNEEDKAKIAKSKKKMRQKVQRGECQTTIQGQARNKR 738
+ ELL+ ++P K+ +E + + E +S + V G R
Sbjct: 999 VKELLDSDSDKPCKEEPMEVDDDMKTESHVNCQESSQVDVVNVSEGF-------HLRTSY 1051
Query: 739 KQETKSLKQK---EAKKKSKAEKEKGKTKQEKLKEKVKREKKEKVK----MKEKEEVTKA 791
K++TKS K E + K +EK + ++ KL+ +K K + E +TKA
Sbjct: 1052 KKKTKSSKLDGLLERRIKQFTLEEKQRLEKIKLEGGIKGIGKTSTNSSKNLSESPVITKA 1111
Query: 792 KPACKAD 798
K C++D
Sbjct: 1112 KEGCQSD 1118
Score = 32.0 bits (71), Expect = 5.9
Identities = 29/129 (22%), Positives = 53/129 (41%), Gaps = 9/129 (6%)
Query: 366 ASPTSPPVLGESVLQDNSFDLNNGSDAEQEEMETQSSDFPPSLTQPAPDQSSTIQLHPAT 425
A + P V +S Q N G + + +Q+ P + +Q +P Q S +Q +
Sbjct: 2318 AQSSKPQVAAQSQPQSNV----QGQSPVRVQSPSQTRIRPSTPSQLSPGQQSQVQTTTSQ 2373
Query: 426 SPAVSPTTSPAVSLVVSPAASPEISPEVCPAASTVVSPAVFSVVSPASSAVLPAVSLEVP 485
+ P T SL + P+ P+V + T+ S + V+ SS P + ++ P
Sbjct: 2374 PIPIQPHT----SLQIPSQGQPQSQPQVQSSTQTLSSGQTLNQVT-VSSPSRPQLQIQQP 2428
Query: 486 LTASVTSPK 494
+ P+
Sbjct: 2429 QPQVIAVPQ 2437
>gi|148612882 cat eye syndrome chromosome region, candidate 2 [Homo
sapiens]
Length = 1484
Score = 75.5 bits (184), Expect = 5e-13
Identities = 42/145 (28%), Positives = 69/145 (47%)
Query: 1760 RRRVLLRGRESPAAGPRYSEEGLSPSKRRRLSMRNHHSDLTFCEIILMEMESHDAAWPFL 1819
R +L +G+E P +++ + D T +L +++H +WPFL
Sbjct: 401 RAWLLAQGKELPPELSHLDPNSPMREEKKTKDLFELDDDFTAMYKVLDVVKAHKDSWPFL 460
Query: 1820 EPVNPRLVSGYRRIIKNPMDFSTMRERLLRGGYTSSEEFAADALLVFDNCQTFNEDDSEV 1879
EPV+ Y +IIK PMD S+M ++L G Y + EEF D +F NC+ +N + SE
Sbjct: 461 EPVDESYAPNYYQIIKAPMDISSMEKKLNGGLYCTKEEFVNDMKTMFRNCRKYNGESSEY 520
Query: 1880 GKAGHIMRRFFESRWEEFYQGKQAN 1904
K + R F + + G+ +
Sbjct: 521 TKMSDNLERCFHRAMMKHFPGEDGD 545
Score = 35.4 bits (80), Expect = 0.54
Identities = 43/167 (25%), Positives = 76/167 (45%), Gaps = 15/167 (8%)
Query: 691 RPLKKLEAQETLNEEDKAKIAKSKKKMRQKVQRGECQTTIQGQARNKRKQETKSLKQKEA 750
R L KL +++ L E K K+ R K + + + +++ET L + E
Sbjct: 269 RQLYKLLSEDFLPEICNMIAQKGKRPQRTKAELHPRWMSDHLSIKPVKQEETPVLTRIE- 327
Query: 751 KKKSKAEKE--------KGKTKQEKLKEKVKREKKEKVKMKEKEEVTKA--KPACKADK- 799
K+K K E+E + K +++ LKE+ KRE +EKVK E + + AC +
Sbjct: 328 KQKRKEEEEERQILLAVQKKEQEQMLKEERKRELEEKVKAVEGMCSVRVVWRGACLSTSR 387
Query: 800 --TLATQRRLEERQRQQMILEEMKKPTEDMCLTDHQPLPDFSRVPGL 844
A +R+L E +R ++ + + P E L + P+ + + L
Sbjct: 388 PVDRAKRRKLRE-ERAWLLAQGKELPPELSHLDPNSPMREEKKTKDL 433
>gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]
Length = 275
Score = 72.8 bits (177), Expect = 3e-12
Identities = 59/207 (28%), Positives = 100/207 (48%), Gaps = 9/207 (4%)
Query: 631 LQWVQLSAEEIPSRIQAITGKRGRPRNTEKAKTKEVPKVKRGRGRPPKVKITEL-LNKTD 689
LQ V S P + K+ R R EK K + + KR RG+ K K + K
Sbjct: 17 LQMVSCSHISKPCTQRESERKKER-REREKRKREREKERKRERGKKEKKKRKKRERGKER 75
Query: 690 NRPLKKLEAQETLNEEDKAKIAKSKKKMRQKVQRGECQTTIQGQARNKRKQETKSLKQKE 749
R K+ E Q E + + K +KK R++ QRG + + + +RK+ + KQ+
Sbjct: 76 ERKRKEREKQRKERREKERRKRKKEKKKRERKQRGRRER----KKKKERKERERENKQRR 131
Query: 750 AKKKSKAEKEKGKTKQEKLKEKVKREKKEKVKMKEKEEVTKAKPACKADKTLATQRRLE- 808
+K+ K K+K + ++++ KE+ KRE+K K + KE+ E + + + K + R E
Sbjct: 132 ERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRER 191
Query: 809 --ERQRQQMILEEMKKPTEDMCLTDHQ 833
ER++++ +E KK + TD Q
Sbjct: 192 KKERKKERRKKKERKKDRKTDRQTDSQ 218
Score = 40.0 bits (92), Expect = 0.022
Identities = 27/120 (22%), Positives = 63/120 (52%), Gaps = 4/120 (3%)
Query: 707 KAKIAKSKKKMRQKVQRGECQTTIQGQARNKRKQETKSLKQKEAKKKSKAEKEKGKTKQE 766
KA +++ K+ ++Q C + + + +++ + ++++ K++ + E+++ + K+E
Sbjct: 3 KAISSRAAVKLNTELQMVSCSHISKPCTQRESERKKERREREKRKREREKERKRERGKKE 62
Query: 767 KLKEKVKREKKEKV-KMKEKEEVTKAKPACKADKTLATQRRLEERQRQQMILEEMKKPTE 825
K K K + KE+ K KE+E+ K + + K +++ E +QR + E KK E
Sbjct: 63 KKKRKKRERGKERERKRKEREKQRKERREKERRKRKKEKKKRERKQRGR---RERKKKKE 119
>gi|153791535 general control of amino acid synthesis 5-like 2 [Homo
sapiens]
Length = 837
Score = 72.0 bits (175), Expect = 5e-12
Identities = 39/123 (31%), Positives = 62/123 (50%), Gaps = 1/123 (0%)
Query: 1775 PRYSEEGLSP-SKRRRLSMRNHHSDLTFCEIILMEMESHDAAWPFLEPVNPRLVSGYRRI 1833
P E G P K + +++ T + +L +++SH +AWPF+EPV Y +
Sbjct: 709 PGIRETGWKPLGKEKGKELKDPDQLYTTLKNLLAQIKSHPSAWPFMEPVKKSEAPDYYEV 768
Query: 1834 IKNPMDFSTMRERLLRGGYTSSEEFAADALLVFDNCQTFNEDDSEVGKAGHIMRRFFESR 1893
I+ P+D TM ERL Y + + F AD V NC+ +N DSE + + +FF +
Sbjct: 769 IRFPIDLKTMTERLRSRYYVTRKLFVADLQRVIANCREYNPPDSEYCRCASALEKFFYFK 828
Query: 1894 WEE 1896
+E
Sbjct: 829 LKE 831
Score = 37.4 bits (85), Expect = 0.14
Identities = 21/62 (33%), Positives = 29/62 (46%), Gaps = 6/62 (9%)
Query: 398 ETQSSDFPPSLTQPAPDQSSTIQLHPATSPAVSPTTSPAVSLVVSPAASPEISPEVCPAA 457
E + P QP P QS PA +P +P SPA + + +P +P +P PA
Sbjct: 3 EPSQAPTPAPAAQPRPLQS------PAPAPTPTPAPSPASAPIPTPTPAPAPAPAAAPAG 56
Query: 458 ST 459
ST
Sbjct: 57 ST 58
Score = 35.4 bits (80), Expect = 0.54
Identities = 20/53 (37%), Positives = 28/53 (52%), Gaps = 4/53 (7%)
Query: 412 APDQSSTIQLHPATSPAVSPTTSPAVSLVVSPAASPEISPEVCPAASTVVSPA 464
AP + Q P SPA +PT +PA S PA++P +P PA + +PA
Sbjct: 7 APTPAPAAQPRPLQSPAPAPTPTPAPS----PASAPIPTPTPAPAPAPAAAPA 55
>gi|11067749 bromodomain containing protein 3 [Homo sapiens]
Length = 726
Score = 71.6 bits (174), Expect = 7e-12
Identities = 61/181 (33%), Positives = 89/181 (49%), Gaps = 25/181 (13%)
Query: 1736 PGFPKRGQKRK--------SGYSLNFSEG-----DGRRRRVLLRGRES---PAAGPRYS- 1778
P K+G KRK S + + SE D ++ +V+ R RES P P+
Sbjct: 235 PVVKKKGVKRKADTTTPTTSAITASRSESPPPLSDPKQAKVVAR-RESGGRPIKPPKKDL 293
Query: 1779 EEGLSPSKRRRLSMRNHHSDLTFCEIILMEMES--HDA-AWPFLEPVNPRLVS--GYRRI 1833
E+G P + + H L +C+ IL EM S H A AWPF +PV+ + Y I
Sbjct: 294 EDGEVPQHAGKKGKLSEH--LRYCDSILREMLSKKHAAYAWPFYKPVDAEALELHDYHDI 351
Query: 1834 IKNPMDFSTMRERLLRGGYTSSEEFAADALLVFDNCQTFNEDDSEVGKAGHIMRRFFESR 1893
IK+PMD ST++ ++ Y ++ FAAD L+F NC +N D EV ++ FE R
Sbjct: 352 IKHPMDLSTVKRKMDGREYPDAQGFAADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMR 411
Query: 1894 W 1894
+
Sbjct: 412 F 412
Score = 57.4 bits (137), Expect = 1e-07
Identities = 27/89 (30%), Positives = 47/89 (52%), Gaps = 2/89 (2%)
Query: 1804 IILMEMESHDAAWPFLEPVNPRLVS--GYRRIIKNPMDFSTMRERLLRGGYTSSEEFAAD 1861
+++ + H AWPF +PV+ ++ Y +IIKNPMD T+++RL Y S+ E D
Sbjct: 45 VVVKTLWKHQFAWPFYQPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYYWSASECMQD 104
Query: 1862 ALLVFDNCQTFNEDDSEVGKAGHIMRRFF 1890
+F NC +N+ ++ + + F
Sbjct: 105 FNTMFTNCYIYNKPTDDIVLMAQALEKIF 133
Score = 53.1 bits (126), Expect = 2e-06
Identities = 102/437 (23%), Positives = 165/437 (37%), Gaps = 42/437 (9%)
Query: 443 PAASPEISPEVCPAASTVVSPAV-FSVVSPASSAVLPAVSLEVP-LTASVTS----PKAS 496
PAA + + AA + VSPA F V P S + VP +TA+VTS P A+
Sbjct: 159 PAAGAQSAGTQQVAAVSSVSPATPFQSVPPTVSQTPVIAATPVPTITANVTSVPVPPAAA 218
Query: 497 PVTSPAAAFPTASPANKDVSSF-LETTADVEEITGEGLTASGSGDVMRRRIATPEEVRLP 555
P P P V ++ AD T +TAS S +V
Sbjct: 219 PPPPATPIVPVVPPTPPVVKKKGVKRKADTTTPTTSAITASRSESPPPLSDPKQAKVVAR 278
Query: 556 LQHGWRREVRIKKGSHRWQGETWYYGPCGKRMKQFPEVIKYLSRNVVHSVRREHFSFS-- 613
+ G R KK GE + GK+ K E ++Y + + ++H +++
Sbjct: 279 RESGGRPIKPPKKDLE--DGEVPQHA--GKKGK-LSEHLRYCDSILREMLSKKHAAYAWP 333
Query: 614 -------PRMPVGDFFEERDTPEGLQWVQ--LSAEEIPSRIQAITGKRGRPRNTEKAKTK 664
+ + D+ + P L V+ + E P R N K
Sbjct: 334 FYKPVDAEALELHDYHDIIKHPMDLSTVKRKMDGREYPDAQGFAADVRLMFSNCYKYNPP 393
Query: 665 EVPKVKRGR----------GRPPKVKITELLNKTDNRPLKKLEAQETLNEEDKAKIAKSK 714
+ V R + P + P+ A+ + + E+ + + S
Sbjct: 394 DHEVVAMARKLQDVFEMRFAKMPDEPVEAPALPAPAAPMVSKGAESSRSSEESSSDSGSS 453
Query: 715 KKMRQKVQR-GECQTTIQGQ----ARNKRKQETKSLKQKEAKKKSKAEKEKGKTKQEKLK 769
++ R E Q ++ A + K K+KE K+K K +K+K K K EK K
Sbjct: 454 DSEEERATRLAELQEQLKAVHEQLAALSQAPVNKPKKKKEKKEKEKKKKDKEKEK-EKHK 512
Query: 770 EKVKREKKEKVKMKEKEEVTKAKPACKADKTLATQRRLEERQRQQMILEEMKKPTEDMCL 829
K + EKK KV K+ K PA KA+ T R+L++ +Q + ++ E + +
Sbjct: 513 VKAEEEKKAKVAPPAKQAQQKKAPAKKANSTTTAGRQLKKGGKQASASYDSEEEEEGLPM 572
Query: 830 T---DHQPLPDFSRVPG 843
+ Q D +R+PG
Sbjct: 573 SYDEKRQLSLDINRLPG 589
>gi|164419758 bromodomain containing 2 [Homo sapiens]
Length = 801
Score = 68.6 bits (166), Expect = 6e-11
Identities = 44/122 (36%), Positives = 66/122 (54%), Gaps = 10/122 (8%)
Query: 1778 SEEGLSPSKRRRLSMRNHHSDLTFCEIILMEMES--HDA-AWPFLEPVNPRLVS--GYRR 1832
S++ SK+ +LS + H C IL E+ S H A AWPF +PV+ + Y
Sbjct: 334 SQQQHQSSKKGKLSEQLKH-----CNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHD 388
Query: 1833 IIKNPMDFSTMRERLLRGGYTSSEEFAADALLVFDNCQTFNEDDSEVGKAGHIMRRFFES 1892
IIK+PMD ST++ ++ Y ++EFAAD L+F NC +N D +V ++ FE
Sbjct: 389 IIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDVFEF 448
Query: 1893 RW 1894
R+
Sbjct: 449 RY 450
Score = 53.9 bits (128), Expect = 1e-06
Identities = 27/102 (26%), Positives = 49/102 (48%), Gaps = 2/102 (1%)
Query: 1803 EIILMEMESHDAAWPFLEPVNPRLVS--GYRRIIKNPMDFSTMRERLLRGGYTSSEEFAA 1860
++++ + H AWPF +PV+ + Y +IIK PMD T++ RL Y ++ E
Sbjct: 84 KVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAASECMQ 143
Query: 1861 DALLVFDNCQTFNEDDSEVGKAGHIMRRFFESRWEEFYQGKQ 1902
D +F NC +N+ ++ + + F + Q +Q
Sbjct: 144 DFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASMPQEEQ 185
>gi|4826806 bromodomain containing 2 [Homo sapiens]
Length = 801
Score = 68.6 bits (166), Expect = 6e-11
Identities = 44/122 (36%), Positives = 66/122 (54%), Gaps = 10/122 (8%)
Query: 1778 SEEGLSPSKRRRLSMRNHHSDLTFCEIILMEMES--HDA-AWPFLEPVNPRLVS--GYRR 1832
S++ SK+ +LS + H C IL E+ S H A AWPF +PV+ + Y
Sbjct: 334 SQQQHQSSKKGKLSEQLKH-----CNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHD 388
Query: 1833 IIKNPMDFSTMRERLLRGGYTSSEEFAADALLVFDNCQTFNEDDSEVGKAGHIMRRFFES 1892
IIK+PMD ST++ ++ Y ++EFAAD L+F NC +N D +V ++ FE
Sbjct: 389 IIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDVFEF 448
Query: 1893 RW 1894
R+
Sbjct: 449 RY 450
Score = 53.9 bits (128), Expect = 1e-06
Identities = 27/102 (26%), Positives = 49/102 (48%), Gaps = 2/102 (1%)
Query: 1803 EIILMEMESHDAAWPFLEPVNPRLVS--GYRRIIKNPMDFSTMRERLLRGGYTSSEEFAA 1860
++++ + H AWPF +PV+ + Y +IIK PMD T++ RL Y ++ E
Sbjct: 84 KVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAASECMQ 143
Query: 1861 DALLVFDNCQTFNEDDSEVGKAGHIMRRFFESRWEEFYQGKQ 1902
D +F NC +N+ ++ + + F + Q +Q
Sbjct: 144 DFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASMPQEEQ 185
>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
Length = 245
Score = 68.2 bits (165), Expect = 7e-11
Identities = 44/167 (26%), Positives = 89/167 (53%), Gaps = 10/167 (5%)
Query: 656 RNTEKAKTKEVPKVKRGRGRPPKVKITELLNKTDNRPLKKLEAQETLNEEDKAKIAKSKK 715
R EK K + + KR RG+ K K + + ++ + +E+K K K+
Sbjct: 64 REREKRKREREKERKRERGKKEK--------KGERKKEERERKKRRREKENKEGEEKEKR 115
Query: 716 KMRQKVQRGECQTTIQGQARNKRKQETKSLKQKEAKKKSKAEKEKGKTKQEKLKEKVKRE 775
K ++K +RG +T+ +G+ R ++++ + +++ +KK + EKE+ + +++K + K E
Sbjct: 116 KKKEKKERG--RTSKEGKERERKEERKREERKERERKKEEREKERERKERKKRERKQVGE 173
Query: 776 KKEKVKMKEKEEVTKAKPACKADKTLATQRRLEERQRQQMILEEMKK 822
K+E+ K KE++E K + K K ++ ER++++ EE KK
Sbjct: 174 KEEERKEKERKERKKRERNRKERKKERERKERRERKKERKKKEERKK 220
Score = 58.5 bits (140), Expect = 6e-08
Identities = 32/136 (23%), Positives = 74/136 (54%)
Query: 651 KRGRPRNTEKAKTKEVPKVKRGRGRPPKVKITELLNKTDNRPLKKLEAQETLNEEDKAKI 710
KR R + ++ + KE K K + R K + + + R ++ + +E EE + +
Sbjct: 99 KRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKER 158
Query: 711 AKSKKKMRQKVQRGECQTTIQGQARNKRKQETKSLKQKEAKKKSKAEKEKGKTKQEKLKE 770
+ ++K R++ Q GE + + + R +RK+ ++ K+++ +++ K +E+ K +++K +
Sbjct: 159 ERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKERKKKEER 218
Query: 771 KVKREKKEKVKMKEKE 786
K +R+K + +EKE
Sbjct: 219 KKERQKDRQTNWREKE 234
Score = 56.2 bits (134), Expect = 3e-07
Identities = 40/159 (25%), Positives = 86/159 (54%), Gaps = 17/159 (10%)
Query: 683 ELLNKTDNRPLKKLEAQETLNEEDKAKIAKSKKKMRQ---KVQRGECQTTIQGQARNKRK 739
E+ + + + ++ E ++ E +K K + K++ R+ K ++GE + + + + +R+
Sbjct: 44 EIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKKRRRE 103
Query: 740 QETKSLKQKEAKKKSKAEKEKGKTKQE----------KLKEKVKREKKEKVKMKEKEEVT 789
+E K ++KE K+K K +KE+G+T +E K +E+ +RE+K++ + KE+E
Sbjct: 104 KENKEGEEKE-KRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKERERKE 162
Query: 790 KAKPACKADKTLATQRR---LEERQRQQMILEEMKKPTE 825
+ K K +R+ +ER++++ +E KK E
Sbjct: 163 RKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERE 201
Score = 55.8 bits (133), Expect = 4e-07
Identities = 38/141 (26%), Positives = 76/141 (53%), Gaps = 6/141 (4%)
Query: 685 LNKTDNRPLKKLEAQETLNEEDKAKIAKSKKKMRQKVQRGECQTTIQGQARNKRKQETKS 744
++K +P + E +E E + K K +++ +K +R E + + + +R++E K
Sbjct: 25 ISKPCTQPGWQSEIREREREIETRKEGKKERESERKKERRERE-----KRKREREKERKR 79
Query: 745 LKQKEAKKKSKAEKEKGKTKQEKLKEKVKREKKEKVKMKEKEEVTKAKPACKADKTLATQ 804
+ K+ KK + ++E+ + K+ + KE + E+KEK K KEK+E + K ++ +
Sbjct: 80 ERGKKEKKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGK-ERERKEE 138
Query: 805 RRLEERQRQQMILEEMKKPTE 825
R+ EER+ ++ EE +K E
Sbjct: 139 RKREERKERERKKEEREKERE 159
Score = 54.7 bits (130), Expect = 9e-07
Identities = 38/179 (21%), Positives = 92/179 (51%), Gaps = 8/179 (4%)
Query: 651 KRGRPRNTEKAKTKEVPKVKRGRGRPPKVKITELLNKTDNRPLKKLEAQETLNEEDKAKI 710
KR R R E+ K + K K+G + + + + + +N+ ++ E ++ ++++ +
Sbjct: 68 KRKREREKER-KRERGKKEKKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRT 126
Query: 711 AKS-----KKKMRQKVQRGECQTTIQGQARNKRKQETKSLKQKEAKKKSKAEKEKGKTKQ 765
+K +K+ R++ +R E + + + + + ++E K ++K+ +K + KEK + ++
Sbjct: 127 SKEGKERERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKER 186
Query: 766 EKLKEKVKREKKEKVK--MKEKEEVTKAKPACKADKTLATQRRLEERQRQQMILEEMKK 822
+K + K KKE+ + +E+++ K K K ++ Q E++R + +E KK
Sbjct: 187 KKRERNRKERKKERERKERRERKKERKKKEERKKERQKDRQTNWREKERGKRERKERKK 245
Score = 53.9 bits (128), Expect = 1e-06
Identities = 47/177 (26%), Positives = 89/177 (50%), Gaps = 19/177 (10%)
Query: 660 KAKTKEVPKVKRGRGRPPKVKITELLNKTDNRPLKKLEAQETLNEE--DKAKIAKSKKKM 717
+ + +E+ K G+ K + +E + R +K E ++ E K K + KK+
Sbjct: 39 REREREIETRKEGK----KERESERKKERREREKRKREREKERKRERGKKEKKGERKKEE 94
Query: 718 RQKVQRGECQTTIQGQARNKRKQETK------SLKQKEAKKKSKAEKEKGKTKQEKLKEK 771
R++ +R + +G+ + KRK++ K S + KE ++K + ++E+ K ++ K +E+
Sbjct: 95 RERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEER 154
Query: 772 VK-REKKEKVKMK-----EKEEVTKAKPACKADKTLATQRRLEERQRQQMILEEMKK 822
K RE+KE+ K + EKEE K K K K R+ +++R++ E KK
Sbjct: 155 EKERERKERKKRERKQVGEKEEERKEKER-KERKKRERNRKERKKERERKERRERKK 210
Score = 41.2 bits (95), Expect = 0.010
Identities = 31/125 (24%), Positives = 62/125 (49%), Gaps = 21/125 (16%)
Query: 707 KAKIAKSKKKMRQKVQRGECQ-----TTIQGQARNKRKQETKSLKQKEAKKKSKAEKEKG 761
KA +++ K+ ++Q C T G R++E + +KE KK+ ++E++K
Sbjct: 3 KAISSRAAVKLNTELQMVSCSHISKPCTQPGWQSEIREREREIETRKEGKKERESERKKE 62
Query: 762 KTKQEKLKEKVKREKKEKVKMKEKEEVTKAKPACKADKTLATQRRLEERQRQQMILEEMK 821
+ ++EK K + ++E+K + KEK+ +R+ EER+R++ E+
Sbjct: 63 RREREKRKREREKERKRERGKKEKKG----------------ERKKEERERKKRRREKEN 106
Query: 822 KPTED 826
K E+
Sbjct: 107 KEGEE 111
>gi|7657218 bromodomain-containing protein 4 isoform short [Homo
sapiens]
Length = 722
Score = 68.2 bits (165), Expect = 7e-11
Identities = 48/140 (34%), Positives = 70/140 (50%), Gaps = 10/140 (7%)
Query: 1760 RRRVLLRGRESPAAGPRYSEEGLSPSKRRRLSMRNHHSDLTFCEIILMEM--ESHDA-AW 1816
+RR R + P S++ +P K ++S L C IL EM + H A AW
Sbjct: 320 QRRESSRPVKPPKKDVPDSQQHPAPEKSSKVS-----EQLKCCSGILKEMFAKKHAAYAW 374
Query: 1817 PFLEPVNPRLVS--GYRRIIKNPMDFSTMRERLLRGGYTSSEEFAADALLVFDNCQTFNE 1874
PF +PV+ + Y IIK+PMD ST++ +L Y ++EF AD L+F NC +N
Sbjct: 375 PFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNP 434
Query: 1875 DDSEVGKAGHIMRRFFESRW 1894
D EV ++ FE R+
Sbjct: 435 PDHEVVAMARKLQDVFEMRF 454
Score = 55.5 bits (132), Expect = 5e-07
Identities = 31/119 (26%), Positives = 59/119 (49%), Gaps = 6/119 (5%)
Query: 1780 EGLSPSKRRRLSMRNHHSDLTFCEIILMEMESHDAAWPFLEPVNPRLVS--GYRRIIKNP 1837
E +P+K +R + + + ++L + H AWPF +PV+ ++ Y +IIK P
Sbjct: 49 ETSNPNKPKRQTNQLQY----LLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTP 104
Query: 1838 MDFSTMRERLLRGGYTSSEEFAADALLVFDNCQTFNEDDSEVGKAGHIMRRFFESRWEE 1896
MD T+++RL Y +++E D +F NC +N+ ++ + + F + E
Sbjct: 105 MDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINE 163
Score = 40.4 bits (93), Expect = 0.017
Identities = 37/155 (23%), Positives = 68/155 (43%), Gaps = 9/155 (5%)
Query: 676 PPKVKITELLNKTDNRPLKKLEAQETLN--EEDKAKIAKSKKKMRQKVQRGECQTTIQGQ 733
PP K+ + +D+ ++ + + EE++A+ ++ + V + Q
Sbjct: 474 PPPTKVVAPPSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQQ 533
Query: 734 ARNKRKQETKSLKQKEA-KKKSKAEKEKGKTKQEKLKEKVKREKKEKVKMKEKEEVTKAK 792
+ K+K++ K K+KE K+K + E+ K K K K KK K V+K +
Sbjct: 534 NKPKKKEKDKKEKKKEKHKRKEEVEENK------KSKAKEPPPKKTKKNNSSNSNVSKKE 587
Query: 793 PACKADKTLATQRRLEERQRQQMILEEMKKPTEDM 827
PA K T EE + + M EE ++ + D+
Sbjct: 588 PAPMKSKPPPTYESEEEDKCKPMSYEEKRQLSLDI 622
Score = 35.8 bits (81), Expect = 0.41
Identities = 37/141 (26%), Positives = 53/141 (37%), Gaps = 30/141 (21%)
Query: 1290 PDSSPGKLDPAPSQPPEEPEPDEAESSPDPQA-----LWFNISAQMPCNAAPTPPPAVSE 1344
P+++ P P P P +A P P + + +P TPPP +
Sbjct: 197 PNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVMTVVPPQPLQTPPPVPPQ 256
Query: 1345 DQ--PTPSPQQLASSKPMNRPSAANPCSPVQFSSTPLAGLAPKRRAG-----------DP 1391
Q P P+PQ + S P+ AA P PV+ KR+A +P
Sbjct: 257 PQPPPAPAPQPVQSHPPI---IAATP-QPVKTKK------GVKRKADTTTPTTIDPIHEP 306
Query: 1392 GEMPQSP--TGLGQPKRRGRP 1410
+P P T LGQ + RP
Sbjct: 307 PSLPPEPKTTKLGQRRESSRP 327
>gi|19718731 bromodomain-containing protein 4 isoform long [Homo
sapiens]
Length = 1362
Score = 68.2 bits (165), Expect = 7e-11
Identities = 48/140 (34%), Positives = 70/140 (50%), Gaps = 10/140 (7%)
Query: 1760 RRRVLLRGRESPAAGPRYSEEGLSPSKRRRLSMRNHHSDLTFCEIILMEM--ESHDA-AW 1816
+RR R + P S++ +P K ++S L C IL EM + H A AW
Sbjct: 320 QRRESSRPVKPPKKDVPDSQQHPAPEKSSKVS-----EQLKCCSGILKEMFAKKHAAYAW 374
Query: 1817 PFLEPVNPRLVS--GYRRIIKNPMDFSTMRERLLRGGYTSSEEFAADALLVFDNCQTFNE 1874
PF +PV+ + Y IIK+PMD ST++ +L Y ++EF AD L+F NC +N
Sbjct: 375 PFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNP 434
Query: 1875 DDSEVGKAGHIMRRFFESRW 1894
D EV ++ FE R+
Sbjct: 435 PDHEVVAMARKLQDVFEMRF 454
Score = 55.5 bits (132), Expect = 5e-07
Identities = 31/119 (26%), Positives = 59/119 (49%), Gaps = 6/119 (5%)
Query: 1780 EGLSPSKRRRLSMRNHHSDLTFCEIILMEMESHDAAWPFLEPVNPRLVS--GYRRIIKNP 1837
E +P+K +R + + + ++L + H AWPF +PV+ ++ Y +IIK P
Sbjct: 49 ETSNPNKPKRQTNQLQY----LLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTP 104
Query: 1838 MDFSTMRERLLRGGYTSSEEFAADALLVFDNCQTFNEDDSEVGKAGHIMRRFFESRWEE 1896
MD T+++RL Y +++E D +F NC +N+ ++ + + F + E
Sbjct: 105 MDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINE 163
Score = 40.8 bits (94), Expect = 0.013
Identities = 58/272 (21%), Positives = 94/272 (34%), Gaps = 54/272 (19%)
Query: 1179 NTTASSPARARGR-----PRKTKPGSMQPRHLKSPVRGQD--SEQPQAQLQPEAQLHAPA 1231
N P+R R P+ +P ++ P ++P+ Q ++ PQ L+ E PA
Sbjct: 864 NALPQQPSRPSNRAAALPPKPARPPAVSPALTQTPLLPQPPMAQPPQVLLEDE---EPPA 920
Query: 1232 QPQPQLQLQLQSHKGFLEQEGSPLSLGQSQHDLSQSAFLSWLSQTQSHSSLLSSSVLTPD 1291
P +Q+QL + L++ P L S SQ L P
Sbjct: 921 PPLTSMQMQLYLQQ--LQKVQPPTPLLPSVKVQSQPP-----------------PPLPPP 961
Query: 1292 SSPG-----KLDPAPSQPPEEPEPDEAESSPDPQALWFNISAQMPCNAAPTPPPAVSEDQ 1346
P + P P PP+ P + + P P+ + ++ PPP +
Sbjct: 962 PHPSVQQQLQQQPPPPPPPQPQPPPQQQHQPPPRPV--HLQPMQFSTHIQQPPPPQGQQP 1019
Query: 1347 PTPSPQQLASSKPMNRPSAANPCSPVQFSSTPLAGLAPKRRAGDP---GEMPQSPTGLGQ 1403
P P P Q +P P P Q +P+ DP G + ++P+
Sbjct: 1020 PHPPPGQ--------QPPPPQPAKPQQVIQ---HHHSPRHHKSDPYSTGHLREAPS---- 1064
Query: 1404 PKRRGRPPSKFFKQMEQRYLTQLTAQPVPPEM 1435
P P F+ + + Q QP E+
Sbjct: 1065 PLMIHSPQMSQFQSLTHQSPPQQNVQPKKQEL 1096
Score = 40.4 bits (93), Expect = 0.017
Identities = 37/155 (23%), Positives = 68/155 (43%), Gaps = 9/155 (5%)
Query: 676 PPKVKITELLNKTDNRPLKKLEAQETLN--EEDKAKIAKSKKKMRQKVQRGECQTTIQGQ 733
PP K+ + +D+ ++ + + EE++A+ ++ + V + Q
Sbjct: 474 PPPTKVVAPPSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQQ 533
Query: 734 ARNKRKQETKSLKQKEA-KKKSKAEKEKGKTKQEKLKEKVKREKKEKVKMKEKEEVTKAK 792
+ K+K++ K K+KE K+K + E+ K K K K KK K V+K +
Sbjct: 534 NKPKKKEKDKKEKKKEKHKRKEEVEENK------KSKAKEPPPKKTKKNNSSNSNVSKKE 587
Query: 793 PACKADKTLATQRRLEERQRQQMILEEMKKPTEDM 827
PA K T EE + + M EE ++ + D+
Sbjct: 588 PAPMKSKPPPTYESEEEDKCKPMSYEEKRQLSLDI 622
Score = 39.7 bits (91), Expect = 0.028
Identities = 33/126 (26%), Positives = 43/126 (34%), Gaps = 30/126 (23%)
Query: 1290 PDSSPGKLDPAPSQPPEEPEPDEAESSPDPQALWFNISAQMPCNAAP----TPPPAVSED 1345
P P + P P QPP P P + + P P MP AAP +PPP ++
Sbjct: 750 PAPVPQQPPPPPQQPPPPPPPQQQQQPPPPPP-----PPSMPQQAAPAMKSSPPPFIATQ 804
Query: 1346 QPTPSPQQLASSKPMNRPSAANPCSPVQFSSTPLAGLAPKRRAGDPGEMPQSPTGLGQPK 1405
P PQ S P+ + P+ L P+ P L QP
Sbjct: 805 VPVLEPQLPGS-----------VFDPIGHFTQPILHL----------PQPELPPHLPQPP 843
Query: 1406 RRGRPP 1411
PP
Sbjct: 844 EHSTPP 849
Score = 35.8 bits (81), Expect = 0.41
Identities = 37/141 (26%), Positives = 53/141 (37%), Gaps = 30/141 (21%)
Query: 1290 PDSSPGKLDPAPSQPPEEPEPDEAESSPDPQA-----LWFNISAQMPCNAAPTPPPAVSE 1344
P+++ P P P P +A P P + + +P TPPP +
Sbjct: 197 PNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVMTVVPPQPLQTPPPVPPQ 256
Query: 1345 DQ--PTPSPQQLASSKPMNRPSAANPCSPVQFSSTPLAGLAPKRRAG-----------DP 1391
Q P P+PQ + S P+ AA P PV+ KR+A +P
Sbjct: 257 PQPPPAPAPQPVQSHPPI---IAATP-QPVKTKK------GVKRKADTTTPTTIDPIHEP 306
Query: 1392 GEMPQSP--TGLGQPKRRGRP 1410
+P P T LGQ + RP
Sbjct: 307 PSLPPEPKTTKLGQRRESSRP 327
Score = 34.7 bits (78), Expect = 0.91
Identities = 31/166 (18%), Positives = 83/166 (50%), Gaps = 10/166 (6%)
Query: 655 PRNTEKAKTKEVPKVKRGRGRPPKVKI----TELLNKTDNRPLKKLEAQETLNEEDKAKI 710
P +K K K+ PK + K+K L+ K P A+ + + ++ +
Sbjct: 1172 PGAPDKDKQKQEPKTPVAPKKDLKIKNMGSWASLVQKHPTTPSST--AKSSSDSFEQFRR 1229
Query: 711 AKSKKKMRQKVQRGECQTTIQGQARNKRKQETKSLKQKEAKKKSKAEKEKGKTKQEKLKE 770
A +K+ R+K + + + + + R R++ +S + ++A ++++ E+ + +QE+ ++
Sbjct: 1230 AAREKEEREKALKAQAEHAEKEKER-LRQERMRSREDEDALEQARRAHEEARRRQEQQQQ 1288
Query: 771 KVKREKKEKVKMKEKEEVTKAKPACKADK--TLATQRRLEERQRQQ 814
+ ++E++++ + + A P ++ + ++ Q+R R+R+Q
Sbjct: 1289 Q-RQEQQQQQQQQAAAVAAAATPQAQSSQPQSMLDQQRELARKREQ 1333
Score = 33.5 bits (75), Expect = 2.0
Identities = 56/249 (22%), Positives = 95/249 (38%), Gaps = 25/249 (10%)
Query: 1192 PRKTKPG--SMQPRHLKSPVRGQDSEQPQAQLQPEAQLHAPAQPQPQLQLQLQSHKGFLE 1249
P++ P S P + + V + + P + P P PQ +L H
Sbjct: 786 PQQAAPAMKSSPPPFIATQVPVLEPQLPGSVFDPIGHFTQPILHLPQPELP--PHLPQPP 843
Query: 1250 QEGSPLSLGQSQHDLSQSAFLSWLSQTQSHSSLLSSSVLTPDSSPGKLDPAPSQPPEEPE 1309
+ +P L Q +S A + L Q S S ++++ + P + PA +Q P P+
Sbjct: 844 EHSTPPHLNQHAV-VSPPALHNALPQQPSRPSNRAAALPPKPARPPAVSPALTQTPLLPQ 902
Query: 1310 PDEAESSPDPQALWFNISAQMPCNAAPTPPPAVSEDQPTPSPQQLASSKPMNRPSAANPC 1369
P A+ PQ L + + P P P ++ Q QQL +P P+ P
Sbjct: 903 PPMAQ---PPQVL---LEDEEP------PAPPLTSMQMQLYLQQLQKVQP---PTPLLPS 947
Query: 1370 SPVQFSSTPLAGLAP----KRRAGDPGEMPQSPTGLGQPKRRGRPPSKFFKQMEQRYLTQ 1425
VQ P P +++ P P P+++ +PP + ++ T
Sbjct: 948 VKVQSQPPPPLPPPPHPSVQQQLQQQPPPPPPPQPQPPPQQQHQPPPRPVHLQPMQFSTH 1007
Query: 1426 LTAQPVPPE 1434
+ QP PP+
Sbjct: 1008 I-QQPPPPQ 1015
>gi|57242796 jumonji, AT rich interactive domain 1B [Homo sapiens]
Length = 1544
Score = 65.9 bits (159), Expect = 4e-10
Identities = 28/62 (45%), Positives = 39/62 (62%)
Query: 1666 RSIAWEKSVNKVTCLVCRKGDNDEFLLLCDGCDRGCHIYCHRPKMEAVPEGDWFCTVCLA 1725
RS +V+ CL+C G++++ LLLCDGCD H +C P + VP+GDW C CLA
Sbjct: 299 RSKKATNAVDLYVCLLCGSGNDEDRLLLCDGCDDSYHTFCLIPPLHDVPKGDWRCPKCLA 358
Query: 1726 QQ 1727
Q+
Sbjct: 359 QE 360
>gi|169218173 PREDICTED: similar to Jumonji, AT rich interactive
domain 1B (RBP2-like), partial [Homo sapiens]
Length = 977
Score = 65.9 bits (159), Expect = 4e-10
Identities = 28/62 (45%), Positives = 39/62 (62%)
Query: 1666 RSIAWEKSVNKVTCLVCRKGDNDEFLLLCDGCDRGCHIYCHRPKMEAVPEGDWFCTVCLA 1725
RS +V+ CL+C G++++ LLLCDGCD H +C P + VP+GDW C CLA
Sbjct: 299 RSKKATNAVDLYVCLLCGSGNDEDRLLLCDGCDDSYHTFCLIPPLHDVPKGDWRCPKCLA 358
Query: 1726 QQ 1727
Q+
Sbjct: 359 QE 360
>gi|153945728 microtubule-associated protein 1B [Homo sapiens]
Length = 2468
Score = 65.1 bits (157), Expect = 6e-10
Identities = 50/185 (27%), Positives = 101/185 (54%), Gaps = 18/185 (9%)
Query: 656 RNTEKAKTKEVPKVKRGRGRPPKVKITELLNKTDNRPLKKLEAQETLNEED--------- 706
R K +T EV KV +PPKV+ E + ++P+K E + ++ E++
Sbjct: 558 RKESKEETPEVTKVNHVE-KPPKVESKEKVMVKKDKPIKT-ETKPSVTEKEVPSKEEPSP 615
Query: 707 -KAKIAKSKKKMRQKVQRGECQTTIQGQARNK---RKQETKSLKQKEAKKKSKAE-KEKG 761
KA++A+ K+ + + T++ + + K +K+E + K++ AKK+ K K++
Sbjct: 616 VKAEVAE--KQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEE 673
Query: 762 KTKQEKLKEKVKREKKEKVKMKEKEEVTKAKPACKADKTLATQRRLEERQRQQMILEEMK 821
K K+E++K++VK+E K++ K + K+EV K P + K + + + E ++ ++ +E+K
Sbjct: 674 KPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIK 733
Query: 822 KPTED 826
K +D
Sbjct: 734 KLPKD 738
Score = 56.6 bits (135), Expect = 2e-07
Identities = 43/178 (24%), Positives = 87/178 (48%), Gaps = 18/178 (10%)
Query: 636 LSAEEIPSRIQAITGKRGRPRNTEKAKTKEVPKVKRGRGRPPKVKITELLNKTDNRPLKK 695
++ +E+PS+ + P E A+ K+ VK + VK + D + K+
Sbjct: 602 VTEKEVPSK------EEPSPVKAEVAE-KQATDVKPKAAKEKTVKKETKVKPEDKKEEKE 654
Query: 696 LEAQETLNEEDKAKIAKSKKKMRQKVQRGECQTTIQGQARNKRKQETKSLKQKEAKKKSK 755
+E +EDK I K +K +++V++ + + + K+E K +KE KK++
Sbjct: 655 KPKKEVAKKEDKTPIKKEEKPKKEEVKK---------EVKKEIKKEEKKEPKKEVKKETP 705
Query: 756 AEKEKGKTKQEKLKEKVKREK--KEKVKMKEKEEVTKAKPACKADKTLATQRRLEERQ 811
++ K + K+E+ KE K EK K+++K K+ + P +A K A + ++ +++
Sbjct: 706 PKEVKKEVKKEEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKE 763
Score = 52.4 bits (124), Expect = 4e-06
Identities = 60/213 (28%), Positives = 108/213 (50%), Gaps = 35/213 (16%)
Query: 624 ERDTPEGLQWVQLSAEEIPSRIQA---ITGKRGRPRNTEKAKT---KEVPKVKRGRGRPP 677
+ +TPE +++ E P ++++ + K+ +P TE + KEVP + P
Sbjct: 562 KEETPEV---TKVNHVEKPPKVESKEKVMVKKDKPIKTETKPSVTEKEVPS--KEEPSPV 616
Query: 678 KVKITELLNKTDNRPLKKLEAQETLNEEDKAKIA---KSKKKMRQKVQRGECQTTIQGQA 734
K ++ E TD +P K ++T+ +E K K + K+K +++V + E +T I+ +
Sbjct: 617 KAEVAEK-QATDVKP--KAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEE 673
Query: 735 RNKRKQETKSLKQKEAKKKSKAEKEKGKTKQEKLKEKVK----REKKEKVKMKEKEEVTK 790
+ K K+E K KE KK+ K E++K E KE K +E K++VK +EK+EV K
Sbjct: 674 KPK-KEEVK----KEVKKEIKKEEKK-----EPKKEVKKETPPKEVKKEVKKEEKKEVKK 723
Query: 791 AKPACKADKTLATQRRLEERQRQQMILEEMKKP 823
+ K + ++ ++ ++ L E KKP
Sbjct: 724 EEKEPKKE----IKKLPKDAKKSSTPLSEAKKP 752
Score = 40.8 bits (94), Expect = 0.013
Identities = 36/145 (24%), Positives = 64/145 (44%), Gaps = 5/145 (3%)
Query: 677 PKVKITELLNKTDNRPLKKLEAQETLNEEDKAKIAKSKKKMRQKVQRGECQTTIQGQARN 736
P KI +L ++ LE E L D K + QK G+ T + Q +
Sbjct: 480 PAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLK----QPLATQKDLTGQVPTPVVKQTKL 535
Query: 737 KRKQETK-SLKQKEAKKKSKAEKEKGKTKQEKLKEKVKREKKEKVKMKEKEEVTKAKPAC 795
K++ +++ SLK SK+ +++ K + ++ + EK KV+ KEK V K KP
Sbjct: 536 KQRADSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKVESKEKVMVKKDKPIK 595
Query: 796 KADKTLATQRRLEERQRQQMILEEM 820
K T++ + ++ + E+
Sbjct: 596 TETKPSVTEKEVPSKEEPSPVKAEV 620
Score = 37.7 bits (86), Expect = 0.11
Identities = 43/175 (24%), Positives = 76/175 (43%), Gaps = 28/175 (16%)
Query: 654 RPRNTEKAKTKEVPKVKRGRGRPPKVKITELLNKTDNRPLKKLEAQETLNEEDKAKIAKS 713
+P T+K T +VP P VK T+L + D+R E+L K +KS
Sbjct: 513 QPLATQKDLTGQVPT--------PVVKQTKLKQRADSR--------ESLKPAAKPLPSKS 556
Query: 714 KKKMRQKVQRGECQTTIQGQARNKRKQETKSLKQKEAKKKSKAEKEKGKTKQEKLKEKVK 773
+K ++ +T + + K K+K KK K K + K + KE
Sbjct: 557 VRKESKE------ETPEVTKVNHVEKPPKVESKEKVMVKKDKPIKTETKPSVTE-KEVPS 609
Query: 774 REKKEKVKMKEKE-EVTKAKPACKADKTLATQRRLEERQRQQMILEEMKKPTEDM 827
+E+ VK + E + T KP +KT+ + +++ ++ EE +KP +++
Sbjct: 610 KEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKK----EEKEKPKKEV 660
>gi|150378543 MYST histone acetyltransferase (monocytic leukemia) 3
[Homo sapiens]
Length = 2004
Score = 64.7 bits (156), Expect = 8e-10
Identities = 39/135 (28%), Positives = 66/135 (48%), Gaps = 24/135 (17%)
Query: 1666 RSIAWEKSVNKVTCLVCR-KGDNDEFLLLCDGCDRGCHIYCHRPKMEAVPEGDWFCTVC- 1723
+++ W+ + TC CR +G N + +L CD CDRG H+ C P + +P+G W C +C
Sbjct: 253 KALRWQ-CIECKTCSSCRDQGKNADNMLFCDSCDRGFHMECCDPPLTRMPKGMWICQICR 311
Query: 1724 -----------LAQQVEGEFTQKPGFPKRGQKRKSGYS------LNFSEGDGRRRRVLLR 1766
A Q++ +T G PK K+++ S + G GR+R++ L
Sbjct: 312 PRKKGRKLLQKKAAQIKRRYTNPIGRPKNRLKKQNTVSKGPFSKVRTGPGRGRKRKITLS 371
Query: 1767 GRESPAAGPRYSEEG 1781
+ + ++ SEEG
Sbjct: 372 SQSASSS----SEEG 382
Score = 40.8 bits (94), Expect = 0.013
Identities = 31/128 (24%), Positives = 48/128 (37%), Gaps = 22/128 (17%)
Query: 1273 LSQTQSHSSLLSSSVLTPDSSPGKLDPA------PSQPPEEPEPDEAESSPDPQALWFNI 1326
+ Q S + S+ +P S + P+ P PP++P+P + P PQ
Sbjct: 1618 MMQQSSVQPAANCSIKSPQSCVVERPPSNQQQQPPPPPPQQPQPPPPQPQPAPQ------ 1671
Query: 1327 SAQMPCNAAPTPPPAVSEDQPTPSPQQLASSKPMNRPSAANPCSPVQFSSTPLAGLAPKR 1386
P PP + QP P PQQ P + + CS + S TP +
Sbjct: 1672 ---------PPPPQQQPQQQPQPQPQQPPPPPPPQQQPPLSQCS-MNNSFTPAPMIMEIP 1721
Query: 1387 RAGDPGEM 1394
+G G +
Sbjct: 1722 ESGSTGNI 1729
Score = 33.9 bits (76), Expect = 1.6
Identities = 45/233 (19%), Positives = 106/233 (45%), Gaps = 23/233 (9%)
Query: 657 NTEKAKTKEVPKVKRGRGRPPKVKITELLNKTDNRPLKKLEAQETLNEEDKA-KIAKSKK 715
N+ + +TKE P+V+ +P +++E +++ ++LE E EED A + A++
Sbjct: 1259 NSPETETKE-PEVEEEEEKP---RVSEEQRQSEEEQ-QELEEPEPEEEEDAAAETAQNDD 1313
Query: 716 KMRQKVQRGECQTTIQGQARNKRKQETKSLKQKEAKKKSKAEKEKGKTKQEKLKEKVKRE 775
G ++T K+K+ + +++ K++ ++ +K +EK+K
Sbjct: 1314 HDADDEDDGHLEST-------KKKELEEQPTREDVKEEPGVQESFLDANMQKSREKIK-- 1364
Query: 776 KKEKVKMKEKEEVTKAKPACKADKTLATQRRLEERQRQQMILEEMKK----PTEDMCLTD 831
KE+ ++ +EE + +++ ++ EE + L E+K+ P ++ L
Sbjct: 1365 DKEETELDSEEEQPSHDTSVVSEQMAGSEDDHEEDSHTKEELIELKEEEEIPHSELDLET 1424
Query: 832 HQPLPDFSRVPGLTLPSGAFSDCLTIVEFLHSFGKVLGFDPAKDVPSLGVLQE 884
Q + ++ + GA+ DC E L + + + A + P + ++++
Sbjct: 1425 VQAVQSLTQEES-SEHEGAYQDC---EETLAACQTLQSYTQADEDPQMSMVED 1473
Score = 32.0 bits (71), Expect = 5.9
Identities = 35/176 (19%), Positives = 80/176 (45%), Gaps = 23/176 (13%)
Query: 655 PRNTEKAKTKEVPKVKRGRGRPPKVKITE-LLNKTDNRPLKKLEAQETLNEEDKAKIAKS 713
P +T+ + + + + GR PK++ +E + ++ PL + +E EE +A+ ++
Sbjct: 1181 PVSTQACVIEPIVSIPKA-GRKPKIQESEETVEPKEDMPLPEERKEE---EEMQAEAEEA 1236
Query: 714 KKKMRQKVQRGECQTTIQGQARNKRKQETKSLKQKEAKKKSKAEKEKGKTKQEKLKEKVK 773
++ + E + N + ETK + +E ++K + +E+ ++++E+ +
Sbjct: 1237 EEGEEEDAASSEVPAASPADSSNSPETETKEPEVEEEEEKPRVSEEQRQSEEEQQE---- 1292
Query: 774 REKKEKVKMKEKEEVTKAKPACKADKTL----------ATQRRLEERQRQQMILEE 819
E+ E E+EE A+ A D ++ LEE+ ++ + EE
Sbjct: 1293 LEEPEP----EEEEDAAAETAQNDDHDADDEDDGHLESTKKKELEEQPTREDVKEE 1344
Score = 32.0 bits (71), Expect = 5.9
Identities = 26/90 (28%), Positives = 33/90 (36%), Gaps = 6/90 (6%)
Query: 1314 ESSPDPQALWFNISAQMPCNAAPTPPPAVSEDQPTPSPQQLASSKPMNRPSAANPCSPVQ 1373
+SS P A N S + P + PP+ + QP P P Q P A P P Q
Sbjct: 1621 QSSVQPAA---NCSIKSPQSCVVERPPSNQQQQPPPPPPQQPQPPPPQPQPAPQPPPPQQ 1677
Query: 1374 FSSTPLAGLAPKRRAGDPGEMPQSPTGLGQ 1403
P P+ + P PQ L Q
Sbjct: 1678 ---QPQQQPQPQPQQPPPPPPPQQQPPLSQ 1704
>gi|150378463 MYST histone acetyltransferase (monocytic leukemia) 3
[Homo sapiens]
Length = 2004
Score = 64.7 bits (156), Expect = 8e-10
Identities = 39/135 (28%), Positives = 66/135 (48%), Gaps = 24/135 (17%)
Query: 1666 RSIAWEKSVNKVTCLVCR-KGDNDEFLLLCDGCDRGCHIYCHRPKMEAVPEGDWFCTVC- 1723
+++ W+ + TC CR +G N + +L CD CDRG H+ C P + +P+G W C +C
Sbjct: 253 KALRWQ-CIECKTCSSCRDQGKNADNMLFCDSCDRGFHMECCDPPLTRMPKGMWICQICR 311
Query: 1724 -----------LAQQVEGEFTQKPGFPKRGQKRKSGYS------LNFSEGDGRRRRVLLR 1766
A Q++ +T G PK K+++ S + G GR+R++ L
Sbjct: 312 PRKKGRKLLQKKAAQIKRRYTNPIGRPKNRLKKQNTVSKGPFSKVRTGPGRGRKRKITLS 371
Query: 1767 GRESPAAGPRYSEEG 1781
+ + ++ SEEG
Sbjct: 372 SQSASSS----SEEG 382
Score = 40.8 bits (94), Expect = 0.013
Identities = 31/128 (24%), Positives = 48/128 (37%), Gaps = 22/128 (17%)
Query: 1273 LSQTQSHSSLLSSSVLTPDSSPGKLDPA------PSQPPEEPEPDEAESSPDPQALWFNI 1326
+ Q S + S+ +P S + P+ P PP++P+P + P PQ
Sbjct: 1618 MMQQSSVQPAANCSIKSPQSCVVERPPSNQQQQPPPPPPQQPQPPPPQPQPAPQ------ 1671
Query: 1327 SAQMPCNAAPTPPPAVSEDQPTPSPQQLASSKPMNRPSAANPCSPVQFSSTPLAGLAPKR 1386
P PP + QP P PQQ P + + CS + S TP +
Sbjct: 1672 ---------PPPPQQQPQQQPQPQPQQPPPPPPPQQQPPLSQCS-MNNSFTPAPMIMEIP 1721
Query: 1387 RAGDPGEM 1394
+G G +
Sbjct: 1722 ESGSTGNI 1729
Score = 33.9 bits (76), Expect = 1.6
Identities = 45/233 (19%), Positives = 106/233 (45%), Gaps = 23/233 (9%)
Query: 657 NTEKAKTKEVPKVKRGRGRPPKVKITELLNKTDNRPLKKLEAQETLNEEDKA-KIAKSKK 715
N+ + +TKE P+V+ +P +++E +++ ++LE E EED A + A++
Sbjct: 1259 NSPETETKE-PEVEEEEEKP---RVSEEQRQSEEEQ-QELEEPEPEEEEDAAAETAQNDD 1313
Query: 716 KMRQKVQRGECQTTIQGQARNKRKQETKSLKQKEAKKKSKAEKEKGKTKQEKLKEKVKRE 775
G ++T K+K+ + +++ K++ ++ +K +EK+K
Sbjct: 1314 HDADDEDDGHLEST-------KKKELEEQPTREDVKEEPGVQESFLDANMQKSREKIK-- 1364
Query: 776 KKEKVKMKEKEEVTKAKPACKADKTLATQRRLEERQRQQMILEEMKK----PTEDMCLTD 831
KE+ ++ +EE + +++ ++ EE + L E+K+ P ++ L
Sbjct: 1365 DKEETELDSEEEQPSHDTSVVSEQMAGSEDDHEEDSHTKEELIELKEEEEIPHSELDLET 1424
Query: 832 HQPLPDFSRVPGLTLPSGAFSDCLTIVEFLHSFGKVLGFDPAKDVPSLGVLQE 884
Q + ++ + GA+ DC E L + + + A + P + ++++
Sbjct: 1425 VQAVQSLTQEES-SEHEGAYQDC---EETLAACQTLQSYTQADEDPQMSMVED 1473
Score = 32.0 bits (71), Expect = 5.9
Identities = 35/176 (19%), Positives = 80/176 (45%), Gaps = 23/176 (13%)
Query: 655 PRNTEKAKTKEVPKVKRGRGRPPKVKITE-LLNKTDNRPLKKLEAQETLNEEDKAKIAKS 713
P +T+ + + + + GR PK++ +E + ++ PL + +E EE +A+ ++
Sbjct: 1181 PVSTQACVIEPIVSIPKA-GRKPKIQESEETVEPKEDMPLPEERKEE---EEMQAEAEEA 1236
Query: 714 KKKMRQKVQRGECQTTIQGQARNKRKQETKSLKQKEAKKKSKAEKEKGKTKQEKLKEKVK 773
++ + E + N + ETK + +E ++K + +E+ ++++E+ +
Sbjct: 1237 EEGEEEDAASSEVPAASPADSSNSPETETKEPEVEEEEEKPRVSEEQRQSEEEQQE---- 1292
Query: 774 REKKEKVKMKEKEEVTKAKPACKADKTL----------ATQRRLEERQRQQMILEE 819
E+ E E+EE A+ A D ++ LEE+ ++ + EE
Sbjct: 1293 LEEPEP----EEEEDAAAETAQNDDHDADDEDDGHLESTKKKELEEQPTREDVKEE 1344
Score = 32.0 bits (71), Expect = 5.9
Identities = 26/90 (28%), Positives = 33/90 (36%), Gaps = 6/90 (6%)
Query: 1314 ESSPDPQALWFNISAQMPCNAAPTPPPAVSEDQPTPSPQQLASSKPMNRPSAANPCSPVQ 1373
+SS P A N S + P + PP+ + QP P P Q P A P P Q
Sbjct: 1621 QSSVQPAA---NCSIKSPQSCVVERPPSNQQQQPPPPPPQQPQPPPPQPQPAPQPPPPQQ 1677
Query: 1374 FSSTPLAGLAPKRRAGDPGEMPQSPTGLGQ 1403
P P+ + P PQ L Q
Sbjct: 1678 ---QPQQQPQPQPQQPPPPPPPQQQPPLSQ 1704
>gi|150378493 MYST histone acetyltransferase (monocytic leukemia) 3
[Homo sapiens]
Length = 2004
Score = 64.7 bits (156), Expect = 8e-10
Identities = 39/135 (28%), Positives = 66/135 (48%), Gaps = 24/135 (17%)
Query: 1666 RSIAWEKSVNKVTCLVCR-KGDNDEFLLLCDGCDRGCHIYCHRPKMEAVPEGDWFCTVC- 1723
+++ W+ + TC CR +G N + +L CD CDRG H+ C P + +P+G W C +C
Sbjct: 253 KALRWQ-CIECKTCSSCRDQGKNADNMLFCDSCDRGFHMECCDPPLTRMPKGMWICQICR 311
Query: 1724 -----------LAQQVEGEFTQKPGFPKRGQKRKSGYS------LNFSEGDGRRRRVLLR 1766
A Q++ +T G PK K+++ S + G GR+R++ L
Sbjct: 312 PRKKGRKLLQKKAAQIKRRYTNPIGRPKNRLKKQNTVSKGPFSKVRTGPGRGRKRKITLS 371
Query: 1767 GRESPAAGPRYSEEG 1781
+ + ++ SEEG
Sbjct: 372 SQSASSS----SEEG 382
Score = 40.8 bits (94), Expect = 0.013
Identities = 31/128 (24%), Positives = 48/128 (37%), Gaps = 22/128 (17%)
Query: 1273 LSQTQSHSSLLSSSVLTPDSSPGKLDPA------PSQPPEEPEPDEAESSPDPQALWFNI 1326
+ Q S + S+ +P S + P+ P PP++P+P + P PQ
Sbjct: 1618 MMQQSSVQPAANCSIKSPQSCVVERPPSNQQQQPPPPPPQQPQPPPPQPQPAPQ------ 1671
Query: 1327 SAQMPCNAAPTPPPAVSEDQPTPSPQQLASSKPMNRPSAANPCSPVQFSSTPLAGLAPKR 1386
P PP + QP P PQQ P + + CS + S TP +
Sbjct: 1672 ---------PPPPQQQPQQQPQPQPQQPPPPPPPQQQPPLSQCS-MNNSFTPAPMIMEIP 1721
Query: 1387 RAGDPGEM 1394
+G G +
Sbjct: 1722 ESGSTGNI 1729
Score = 33.9 bits (76), Expect = 1.6
Identities = 45/233 (19%), Positives = 106/233 (45%), Gaps = 23/233 (9%)
Query: 657 NTEKAKTKEVPKVKRGRGRPPKVKITELLNKTDNRPLKKLEAQETLNEEDKA-KIAKSKK 715
N+ + +TKE P+V+ +P +++E +++ ++LE E EED A + A++
Sbjct: 1259 NSPETETKE-PEVEEEEEKP---RVSEEQRQSEEEQ-QELEEPEPEEEEDAAAETAQNDD 1313
Query: 716 KMRQKVQRGECQTTIQGQARNKRKQETKSLKQKEAKKKSKAEKEKGKTKQEKLKEKVKRE 775
G ++T K+K+ + +++ K++ ++ +K +EK+K
Sbjct: 1314 HDADDEDDGHLEST-------KKKELEEQPTREDVKEEPGVQESFLDANMQKSREKIK-- 1364
Query: 776 KKEKVKMKEKEEVTKAKPACKADKTLATQRRLEERQRQQMILEEMKK----PTEDMCLTD 831
KE+ ++ +EE + +++ ++ EE + L E+K+ P ++ L
Sbjct: 1365 DKEETELDSEEEQPSHDTSVVSEQMAGSEDDHEEDSHTKEELIELKEEEEIPHSELDLET 1424
Query: 832 HQPLPDFSRVPGLTLPSGAFSDCLTIVEFLHSFGKVLGFDPAKDVPSLGVLQE 884
Q + ++ + GA+ DC E L + + + A + P + ++++
Sbjct: 1425 VQAVQSLTQEES-SEHEGAYQDC---EETLAACQTLQSYTQADEDPQMSMVED 1473
Score = 32.0 bits (71), Expect = 5.9
Identities = 35/176 (19%), Positives = 80/176 (45%), Gaps = 23/176 (13%)
Query: 655 PRNTEKAKTKEVPKVKRGRGRPPKVKITE-LLNKTDNRPLKKLEAQETLNEEDKAKIAKS 713
P +T+ + + + + GR PK++ +E + ++ PL + +E EE +A+ ++
Sbjct: 1181 PVSTQACVIEPIVSIPKA-GRKPKIQESEETVEPKEDMPLPEERKEE---EEMQAEAEEA 1236
Query: 714 KKKMRQKVQRGECQTTIQGQARNKRKQETKSLKQKEAKKKSKAEKEKGKTKQEKLKEKVK 773
++ + E + N + ETK + +E ++K + +E+ ++++E+ +
Sbjct: 1237 EEGEEEDAASSEVPAASPADSSNSPETETKEPEVEEEEEKPRVSEEQRQSEEEQQE---- 1292
Query: 774 REKKEKVKMKEKEEVTKAKPACKADKTL----------ATQRRLEERQRQQMILEE 819
E+ E E+EE A+ A D ++ LEE+ ++ + EE
Sbjct: 1293 LEEPEP----EEEEDAAAETAQNDDHDADDEDDGHLESTKKKELEEQPTREDVKEE 1344
Score = 32.0 bits (71), Expect = 5.9
Identities = 26/90 (28%), Positives = 33/90 (36%), Gaps = 6/90 (6%)
Query: 1314 ESSPDPQALWFNISAQMPCNAAPTPPPAVSEDQPTPSPQQLASSKPMNRPSAANPCSPVQ 1373
+SS P A N S + P + PP+ + QP P P Q P A P P Q
Sbjct: 1621 QSSVQPAA---NCSIKSPQSCVVERPPSNQQQQPPPPPPQQPQPPPPQPQPAPQPPPPQQ 1677
Query: 1374 FSSTPLAGLAPKRRAGDPGEMPQSPTGLGQ 1403
P P+ + P PQ L Q
Sbjct: 1678 ---QPQQQPQPQPQQPPPPPPPQQQPPLSQ 1704
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 64.3 bits (155), Expect = 1e-09
Identities = 108/501 (21%), Positives = 185/501 (36%), Gaps = 39/501 (7%)
Query: 354 LADDSQTSTSIFASPTSPPVLGESVLQDNSFDLNNGSDAEQEEMETQSSDFPPSLTQPAP 413
+ + S+ T I T + E V ++ + E+E E + ++ T+ P
Sbjct: 446 VVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPP 505
Query: 414 DQSSTIQLHPATSPAVSPTTSPAVSLVVSPAASPEISPEVCPAASTVVSPAVFSVVSPAS 473
+ + A SP SPA + SP SP + SPA SP
Sbjct: 506 AEEAASPEKEAKSPVKEEAKSPAEAK--SPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPE 563
Query: 474 S-------AVLPAVSLEVPLTASVTSPKASPVTSPAAAFP---TASPANKDVSSFLETTA 523
+ A PA EV SP SPA A SP ++ S E +
Sbjct: 564 AKSPEKEEAKSPA---EVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKS 620
Query: 524 DVEEITGEGLTASGSGDVMRRRIATPEEVRLPLQHGWRREVRIKKGSHRWQGETWYYGPC 583
V+E E + + + + T EE + P + E K + +
Sbjct: 621 PVKE---EAKSPAEVKSPEKAKSPTKEEAKSP-EKAKSPEKEEAKSPEKAKSPVKAEAKS 676
Query: 584 GKRMKQFPEVIKYLSRNVVHSVRREHFSFSPRMPVGDFFEERDTPEGLQWVQLSAEEIPS 643
++ K + V+ E + SP EE +PE + + P
Sbjct: 677 PEKAKSPVKAEAKSPEKAKSPVKEE--AKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPE 734
Query: 644 RIQAITGKRGRP----RNTEKAKTKEV--PKVK---RGRGRPPKVKITELLNKTDNRPLK 694
+ ++ + + ++ EKAKT +V P+ K + R P K E +K
Sbjct: 735 KAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVK 794
Query: 695 KLE-AQETLNEEDKA--KIAKSKKKMRQKVQRGECQTTIQGQARNKRKQETKSL------ 745
E A+ L E+ KA K K++++ V+ E ++ + K+ +E K+
Sbjct: 795 SPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTE 854
Query: 746 KQKEAKKKSKAEKEKGKTKQEKLKEKVKREKKEKVKMKEKEEVTKAKPACKADKTLATQR 805
++K++KK+ +KE K K E+ KE + KE +KEE K +K +
Sbjct: 855 EKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKV 914
Query: 806 RLEERQRQQMILEEMKKPTED 826
++E + + E KK +D
Sbjct: 915 EVKEDAKPKEKTEVAKKEPDD 935
Score = 63.9 bits (154), Expect = 1e-09
Identities = 94/436 (21%), Positives = 169/436 (38%), Gaps = 45/436 (10%)
Query: 390 SDAEQEEMETQSSDFPPSLTQPAPDQSSTIQLHPATSPAVSPTTSPAVSLVVSPAASPEI 449
S AE + E S PA +S P A SP + SP
Sbjct: 594 SPAEAKSPEKAKSPVKEEAKSPAEAKS------PVKEEAKSPAEVKSPEKAKSPTKEEAK 647
Query: 450 SPEVCPAASTVVSPAVFSVVSPASSAVLPAVSLEVPLTASVTSPKA--SPVTSPAAAFPT 507
SPE + + + SP + + P+ A SP+ SPV A +
Sbjct: 648 SPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEK 707
Query: 508 A-SPANKDVSSFLETTADVEEITGEGLTASGSGDVMRRRIATPEEVRLPLQHGWRREVRI 566
A SP ++ S + + V+E E T + ++ +PE+ + P + + + +
Sbjct: 708 AKSPVKEEAKSPEKAKSPVKE---EAKTPEKAKSPVKEEAKSPEKAKSPEK---AKTLDV 761
Query: 567 KKGSHRWQGETWYYGPCGKRMKQFPEVIKYLSRNVVHSVRREHFSFSPRMPVGDFFEERD 626
K + + P K FPE K + V S + E++
Sbjct: 762 KSPEAKTPAKEEARSPADK----FPEKAKSPVKEEVKSPEKAKSPLKEDAKA----PEKE 813
Query: 627 TPEGLQWVQ-LSAEEIPSRIQAITGKRGRPRNTEKAKTKEVPKVKRGRG---------RP 676
P+ + + EE P ++ + P+ E+ K PK + +
Sbjct: 814 IPKKEEVKSPVKEEEKPQEVKV----KEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEA 869
Query: 677 PKVKITELLNKTDNRPLK-KLEAQETLNEEDKAKIAKSKKKMRQKVQ-RGECQTTIQGQA 734
PK K+ E +P + K+EA++ EDK K+ +K+ KV+ + + + + +
Sbjct: 870 PKPKVEEKKEPAVEKPKESKVEAKKE-EAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEV 928
Query: 735 RNKRKQETKSLKQKEAKKKSKAEKEKGKTKQEKLKEKVKREKKEKVKMKEKEEVTKAKP- 793
K + K+ + + +K +A EK TK+EK K K + + K + K KE ++ +P
Sbjct: 929 AKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAK-KPEEKPKTEAKAKEDDKTLSKEPS 987
Query: 794 ---ACKADKTLATQRR 806
A KA+K+ +T ++
Sbjct: 988 KPKAEKAEKSSSTDQK 1003
Score = 59.3 bits (142), Expect = 3e-08
Identities = 102/451 (22%), Positives = 172/451 (38%), Gaps = 72/451 (15%)
Query: 390 SDAEQEEMETQSSDFPPSLTQPAPDQSSTIQLHPATSPAVSPTTSPAVSLVVSPAASP-E 448
S AE + E S PA +S P A SP + A S V A SP E
Sbjct: 574 SPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSP--AEAKSPVKEEAKSPAE 631
Query: 449 I-SPEVCPAASTVVSPAVFSVVSPASSAVLPAVSLEVPLTASVTSPKA--SPVTSPAAAF 505
+ SPE + + + + SP + P+ A SP+ SPV + A +
Sbjct: 632 VKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSP 691
Query: 506 PTA-SPANKDVSSFLETTADVEEITGEGLTASGSGDVMRRRIATPEEVRLPLQHGWRREV 564
A SP ++ S + + V+E E + + ++ TPE+ + P++ +
Sbjct: 692 EKAKSPVKEEAKSPEKAKSPVKE---EAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPE 748
Query: 565 RIKKGSHRWQGETWYYGPCGKRMKQFPEVIKYLSRNVVHSVRREHFSFSPRMPVGDFFEE 624
+ K PE K L +V + R P F E+
Sbjct: 749 KAKS----------------------PEKAKTL--DVKSPEAKTPAKEEARSPADKFPEK 784
Query: 625 RDTPEGLQWVQLSAEEIPSRIQAITGKRGRPRNTEKAKTKEVPKVKRGRG------RPPK 678
+P EE+ S +A + + KA KE+PK + + +P +
Sbjct: 785 AKSPV--------KEEVKSPEKA----KSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQE 832
Query: 679 VKITELLNKTDNRPLK---KLEAQETLNEEDKAKIAKSKKKMRQKVQRGECQTTIQGQAR 735
VK+ E K + K E ++ +E+ K K K+ +K + A
Sbjct: 833 VKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKE----------PAV 882
Query: 736 NKRKQETKSLKQKEAKKKSKAEK-EKGKTKQEKLKEKVKREKKEKVKMKEKEEVTKAKPA 794
K K+ K++EA+ K K EK + ++KE K ++K +V KE ++ +P+
Sbjct: 883 EKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPS 942
Query: 795 CKADKTLATQRRLEERQRQQMILEEMKKPTE 825
A+K A + + ++ E+ KKP E
Sbjct: 943 KPAEKKEAAPEKKDTKE------EKAKKPEE 967
Score = 58.5 bits (140), Expect = 6e-08
Identities = 99/479 (20%), Positives = 181/479 (37%), Gaps = 40/479 (8%)
Query: 357 DSQTSTSIFASPTSPPVLGESVLQDNSFDLNNGSDAEQEEMETQSS-DFPPSLTQPAPDQ 415
+ +T + SP +S +++ + E+EE ++ + P PA ++
Sbjct: 498 EEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEE 557
Query: 416 SSTIQ--LHPATSPAVSPTTSPAVSLVVSPAASPEISPEVCPAASTVVSPAVFSVVSPAS 473
+ + P A SP + SPA SP + SP SPA
Sbjct: 558 AKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAE 617
Query: 474 SAVLPAVSLEVPLTASVTSP-KASPVTSPAAAFP--TASPANKDVSSFLETTADVEEITG 530
+ V E A V SP KA T A P SP ++ S + + V+
Sbjct: 618 AK--SPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVK---A 672
Query: 531 EGLTASGSGDVMRRRIATPEEVRLPLQHGWRREVRIKKGSHRWQGETWYYGPCGKRMKQF 590
E + + ++ +PE+ + P++ + + K P + K
Sbjct: 673 EAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAK-------------SPVKEEAKS- 718
Query: 591 PEVIKYLSRNVVHSVRREHFSFSPRMPVGDFFEERDTPEGLQWVQLSAEE--IPSRIQAI 648
PE K V + + SP E+ +PE + + + + E P++ +A
Sbjct: 719 PEKAK---SPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEA- 774
Query: 649 TGKRGRPRNTEKAKTKEVPKVKRGRGRPPKVK--ITELLNKTDNRPLKKLEAQETLNEED 706
+ + EKAK+ +VK P K K + E + KK E + + EE+
Sbjct: 775 --RSPADKFPEKAKSPVKEEVK----SPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEE 828
Query: 707 KAKIAKSKKKMRQKVQRGECQTTIQGQARNKRKQETKSLKQKEAKKKSKAEKEKGKTKQE 766
K + K K+ ++ + T + ++ +K+E + + K + K E K K+
Sbjct: 829 KPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKES 888
Query: 767 KLKEKVKREKKEKVKMKEKEEVTKAKPACKADKTLATQRRLEERQRQQMILEEMKKPTE 825
K++ K K E ++K K+ E+ AK K D + + +++ +E KP E
Sbjct: 889 KVEAK-KEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAE 946
Score = 40.4 bits (93), Expect = 0.017
Identities = 50/210 (23%), Positives = 87/210 (41%), Gaps = 27/210 (12%)
Query: 628 PEGLQWVQLSAEEIPSRIQAITGKRGRPRNTEKAKTKEVPKVKRGRGRPPKVKITELLNK 687
PEGL +IPS I K + KE V+ + + ++TE + +
Sbjct: 423 PEGLP-------KIPSVSTHIKVKSEEKIKVVEKSEKETVIVEE---QTEETQVTEEVTE 472
Query: 688 TDNRPLKKLEAQETLN-EEDKAKIAKSKKKMRQKVQRGECQTTIQGQARNKRKQETKSLK 746
+ + K+ E +E EE++A+ + + K E + + +A++ K+E KS
Sbjct: 473 EEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPP----AEEAASPEKEAKSPVKEEAKSPA 528
Query: 747 QKEAKKKSKAEKEKGKTKQEKLKEKVKREKKE--KVKMKEKEEV---------TKAKPAC 795
+ ++ +K +A+ EK K K E K + K EKEE KAK
Sbjct: 529 EAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPA 588
Query: 796 KADKTLATQRRLEERQRQQMILEEMKKPTE 825
K + + + E+ + + EE K P E
Sbjct: 589 KEEAKSPAEAKSPEKAKSP-VKEEAKSPAE 617
Score = 34.7 bits (78), Expect = 0.91
Identities = 35/142 (24%), Positives = 56/142 (39%), Gaps = 13/142 (9%)
Query: 1292 SSPGKLDPAP----SQPPEEPEPDEAESSPDPQALWFNISAQMPCNA-APTPPPAVS-ED 1345
+SP K +P ++ P E + E E + P + A+ P A +PP A S E
Sbjct: 510 ASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEK 569
Query: 1346 QPTPSPQQLASSKPMNRPSAANPCSPVQFSSTPLAGLAPKRRAGDPGEM-------PQSP 1398
+ SP ++ S + P+ SP + S A K A P E +SP
Sbjct: 570 EEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSP 629
Query: 1399 TGLGQPKRRGRPPSKFFKQMEQ 1420
+ P++ P + K E+
Sbjct: 630 AEVKSPEKAKSPTKEEAKSPEK 651
Score = 33.1 bits (74), Expect = 2.7
Identities = 55/235 (23%), Positives = 96/235 (40%), Gaps = 23/235 (9%)
Query: 1182 ASSPARARGRPRKTKPGSMQPRHLKSPVRGQDSEQPQAQLQPEAQLHAPAQPQPQLQLQL 1241
A SPA A+ P K + S P +KSP + + + +A+ PEA+ +P + + + ++
Sbjct: 524 AKSPAEAKS-PEKEEAKS--PAEVKSPEKAKSPAKEEAKSPPEAK--SPEKEEAKSPAEV 578
Query: 1242 QS---HKGFLEQEGSPLSLGQSQHDLSQSAFLSWLSQTQSHSSLLS-----SSVLTPD-- 1291
+S K ++E + +S S ++ S + + V +P+
Sbjct: 579 KSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKA 638
Query: 1292 SSPGKLDPAPSQPPEEPEPDEAES-----SPDPQALWFNISAQMPCNA-APTPPPAVSE- 1344
SP K + + + PE +EA+S SP A+ P A A +P A S
Sbjct: 639 KSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPV 698
Query: 1345 DQPTPSPQQLASSKPMNRPSAANPCSPV-QFSSTPLAGLAPKRRAGDPGEMPQSP 1398
+ SP++ S S SPV + + TP +P + E +SP
Sbjct: 699 KEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSP 753
Score = 32.0 bits (71), Expect = 5.9
Identities = 43/232 (18%), Positives = 84/232 (36%), Gaps = 21/232 (9%)
Query: 1145 PEEVIKKETDSLKVAAHASLNPALFSMKMELAGSNTTASSPARARGRPRKTKPGSMQPRH 1204
P E E V A S E A S SP +A+ TK + P
Sbjct: 595 PAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKS---PTKEEAKSPEK 651
Query: 1205 LKSPVRGQDSEQPQAQLQPEAQLHAPAQPQPQLQLQLQSHKGFLEQEGSPLSLGQSQHDL 1264
KSP + + +A+ +A+ +P + + ++ + +S E+ SP+ +
Sbjct: 652 AKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSP----EKAKSPVKEEAKSPEK 707
Query: 1265 SQSAFLSWLSQTQSHSSLLSSSVLTPDSSPGKLDPAPSQPPEEPEPDEAES----SPDPQ 1320
++S + S + TP+ + + P + P++A++ SP+
Sbjct: 708 AKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPE-- 765
Query: 1321 ALWFNISAQMPC-NAAPTPPPAVSEDQPTPSPQQLASSKPMNRPSAANPCSP 1371
A+ P A +P E +P +++ S + P + +P
Sbjct: 766 -------AKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAP 810
>gi|46399200 testis-specific bromodomain protein [Homo sapiens]
Length = 947
Score = 64.3 bits (155), Expect = 1e-09
Identities = 35/103 (33%), Positives = 54/103 (52%), Gaps = 5/103 (4%)
Query: 1799 LTFCEIILMEM---ESHDAAWPFLEPVNPRLVS--GYRRIIKNPMDFSTMRERLLRGGYT 1853
L C IL EM + AWPF PV+ + Y ++KNPMD T++E++ Y
Sbjct: 273 LRHCSEILKEMLAKKHFSYAWPFYNPVDVNALGLHNYYDVVKNPMDLGTIKEKMDNQEYK 332
Query: 1854 SSEEFAADALLVFDNCQTFNEDDSEVGKAGHIMRRFFESRWEE 1896
+ +FAAD L+F NC +N D EV +++ FE+ + +
Sbjct: 333 DAYKFAADVRLMFMNCYKYNPPDHEVVTMARMLQDVFETHFSK 375
Score = 57.0 bits (136), Expect = 2e-07
Identities = 28/102 (27%), Positives = 51/102 (50%), Gaps = 2/102 (1%)
Query: 1803 EIILMEMESHDAAWPFLEPVNPRLVS--GYRRIIKNPMDFSTMRERLLRGGYTSSEEFAA 1860
+++L ++ H +WPF PV+ + Y IIKNPMD +T+++RL Y + E
Sbjct: 37 KVVLKDLWKHSFSWPFQRPVDAVKLQLPDYYTIIKNPMDLNTIKKRLENKYYAKASECIE 96
Query: 1861 DALLVFDNCQTFNEDDSEVGKAGHIMRRFFESRWEEFYQGKQ 1902
D +F NC +N+ ++ + + F + + Q +Q
Sbjct: 97 DFNTMFSNCYLYNKPGDDIVLMAQALEKLFMQKLSQMPQEEQ 138
Score = 42.4 bits (98), Expect = 0.004
Identities = 31/121 (25%), Positives = 63/121 (52%), Gaps = 6/121 (4%)
Query: 678 KVKITELLNKTD-NRPLKKLEAQETLNEEDKAKIAKSKKKMRQKVQRGECQTTIQGQARN 736
K ITE + + N + + + +E ++AK +++++ Q+ + + + + N
Sbjct: 390 KTDITETTGRENTNEASSEGNSSDDSEDERVKRLAKLQEQLKAVHQQLQVLSQVPFRKLN 449
Query: 737 KRKQETKSLKQKEAKKKSKAEKEKGKTKQEKLKEKVKREKKEKVKMK----EKEEVTKAK 792
K+K+++K K+KE K + E + +Q +LKEK KR + +K K + + E+ AK
Sbjct: 450 KKKEKSKKEKKKE-KVNNSNENPRKMCEQMRLKEKSKRNQPKKRKQQFIGLKSEDEDNAK 508
Query: 793 P 793
P
Sbjct: 509 P 509
Score = 35.4 bits (80), Expect = 0.54
Identities = 29/119 (24%), Positives = 50/119 (42%), Gaps = 13/119 (10%)
Query: 698 AQETLNEEDKAKIAKSKKKMRQKVQRGECQTTIQGQARNKRKQETKSLKQKEAKKKSKAE 757
+ E N+ KA I K K Q++ R +Q TK LK + ++
Sbjct: 822 SDELFNQFRKAAIEKEVKARTQEL------------IRKHLEQNTKELKASQENQRDLGN 869
Query: 758 KEKGKTKQEKLKEKVKREKKEKVKMKEKEEVTKAKPACKADKTLATQRRLEERQRQQMI 816
++ K++ K E+ +K + E K+K D+ LA Q+ E R+R+ M+
Sbjct: 870 GLTVESFSNKIQNKCSGEE-QKEHQQSSEAQDKSKLWLLKDRDLARQKEQERRRREAMV 927
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.130 0.383
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 85,188,967
Number of Sequences: 37866
Number of extensions: 4810098
Number of successful extensions: 48134
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 532
Number of HSP's successfully gapped in prelim test: 1628
Number of HSP's that attempted gapping in prelim test: 23144
Number of HSP's gapped (non-prelim): 15293
length of query: 1905
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1788
effective length of database: 13,817,196
effective search space: 24705146448
effective search space used: 24705146448
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.