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Search of human proteins with 8924258
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|8924258 gamma-aminobutyric acid (GABA) receptor, theta
precursor [Homo sapiens]
(632 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|8924258 gamma-aminobutyric acid (GABA) receptor, theta precur... 1297 0.0
gi|4503865 gamma-aminobutyric acid (GABA) A receptor, beta 2 iso... 370 e-102
gi|12548785 gamma-aminobutyric acid (GABA) A receptor, beta 2 is... 370 e-102
gi|12548788 gamma-aminobutyric acid (GABA) A receptor, beta 3 is... 368 e-102
gi|4503867 gamma-aminobutyric acid (GABA) A receptor, beta 3 iso... 368 e-102
gi|194097327 gamma-aminobutyric acid (GABA) A receptor, beta 1 p... 368 e-101
gi|34734071 gamma-aminobutyric acid (GABA) A receptor, delta pre... 278 8e-75
gi|119372310 glycine receptor, alpha 1 isoform 2 precursor [Homo... 263 4e-70
gi|194097386 gamma-aminobutyric acid (GABA) receptor, rho 1 [Hom... 262 8e-70
gi|225903367 glycine receptor, alpha 1 isoform 1 precursor [Homo... 259 4e-69
gi|169646728 glycine receptor, alpha 2 isoform B [Homo sapiens] 259 5e-69
gi|169646723 glycine receptor, alpha 2 isoform A [Homo sapiens] 259 7e-69
gi|4504021 glycine receptor, alpha 2 isoform A [Homo sapiens] 259 7e-69
gi|157743288 gamma-aminobutyric acid (GABA) receptor, rho 3 [Hom... 257 3e-68
gi|218156328 glycine receptor, alpha 4 precursor [Homo sapiens] 255 1e-67
gi|153266866 gamma-aminobutyric acid (GABA) receptor, rho 2 prec... 254 2e-67
gi|110347433 glycine receptor, alpha 3 isoform b [Homo sapiens] 251 1e-66
gi|110347441 glycine receptor, alpha 3 isoform a [Homo sapiens] 251 1e-66
gi|7657106 gamma-aminobutyric acid (GABA) A receptor, pi [Homo s... 251 2e-66
gi|110347416 gamma-aminobutyric acid (GABA) A receptor, gamma 3 ... 246 5e-65
gi|38788135 gamma-aminobutyric acid A receptor, gamma 2 isoform ... 241 1e-63
gi|38788155 gamma-aminobutyric acid A receptor, gamma 2 isoform ... 241 1e-63
gi|157389018 gamma-aminobutyric acid A receptor, alpha 6 precurs... 236 5e-62
gi|31742490 gamma-aminobutyric acid A receptor, gamma 1 precurso... 231 2e-60
gi|52426761 gamma-aminobutyric acid (GABA) A receptor, epsilon p... 230 3e-60
gi|4504023 glycine receptor, beta [Homo sapiens] 228 1e-59
gi|189083734 gamma-aminobutyric acid (GABA) A receptor, alpha 1 ... 228 1e-59
gi|189083732 gamma-aminobutyric acid (GABA) A receptor, alpha 1 ... 228 1e-59
gi|189083730 gamma-aminobutyric acid (GABA) A receptor, alpha 1 ... 228 1e-59
gi|189083728 gamma-aminobutyric acid (GABA) A receptor, alpha 1 ... 228 1e-59
>gi|8924258 gamma-aminobutyric acid (GABA) receptor, theta precursor
[Homo sapiens]
Length = 632
Score = 1297 bits (3357), Expect = 0.0
Identities = 632/632 (100%), Positives = 632/632 (100%)
Query: 1 MGIRGMLRAAVILLLIRTWLAEGNYPSPIPKFHFEFSSAVPEVVLNLFNCKNCANEAVVQ 60
MGIRGMLRAAVILLLIRTWLAEGNYPSPIPKFHFEFSSAVPEVVLNLFNCKNCANEAVVQ
Sbjct: 1 MGIRGMLRAAVILLLIRTWLAEGNYPSPIPKFHFEFSSAVPEVVLNLFNCKNCANEAVVQ 60
Query: 61 KILDRVLSRYDVRLRPNFGGAPVPVRISIYVTSIEQISEMNMDYTITMFFHQTWKDSRLA 120
KILDRVLSRYDVRLRPNFGGAPVPVRISIYVTSIEQISEMNMDYTITMFFHQTWKDSRLA
Sbjct: 61 KILDRVLSRYDVRLRPNFGGAPVPVRISIYVTSIEQISEMNMDYTITMFFHQTWKDSRLA 120
Query: 121 YYETTLNLTLDYRMHEKLWVPDCYFLNSKDAFVHDVTVENRVFQLHPDGTVRYGIRLTTT 180
YYETTLNLTLDYRMHEKLWVPDCYFLNSKDAFVHDVTVENRVFQLHPDGTVRYGIRLTTT
Sbjct: 121 YYETTLNLTLDYRMHEKLWVPDCYFLNSKDAFVHDVTVENRVFQLHPDGTVRYGIRLTTT 180
Query: 181 AACSLDLHKFPMDKQACNLVVESYGYTVEDIILFWDDNGNAIHMTEELHIPQFTFLGRTI 240
AACSLDLHKFPMDKQACNLVVESYGYTVEDIILFWDDNGNAIHMTEELHIPQFTFLGRTI
Sbjct: 181 AACSLDLHKFPMDKQACNLVVESYGYTVEDIILFWDDNGNAIHMTEELHIPQFTFLGRTI 240
Query: 241 TSKEVYFYTGSYIRLILKFQVQREVNSYLVQVYWPTVLTTITSWISFWMNYDSSAARVTI 300
TSKEVYFYTGSYIRLILKFQVQREVNSYLVQVYWPTVLTTITSWISFWMNYDSSAARVTI
Sbjct: 241 TSKEVYFYTGSYIRLILKFQVQREVNSYLVQVYWPTVLTTITSWISFWMNYDSSAARVTI 300
Query: 301 GLTSMLILTTIDSHLRDKLPNISCIKAIDIYILVCLFFVFLSLLEYVYINYLFYSRGPRR 360
GLTSMLILTTIDSHLRDKLPNISCIKAIDIYILVCLFFVFLSLLEYVYINYLFYSRGPRR
Sbjct: 301 GLTSMLILTTIDSHLRDKLPNISCIKAIDIYILVCLFFVFLSLLEYVYINYLFYSRGPRR 360
Query: 361 QPRRHRRPRRVIARYRYQQVVVGNVQDGLINVEDGVSSLPITPAQAPLASPESLGSLTST 420
QPRRHRRPRRVIARYRYQQVVVGNVQDGLINVEDGVSSLPITPAQAPLASPESLGSLTST
Sbjct: 361 QPRRHRRPRRVIARYRYQQVVVGNVQDGLINVEDGVSSLPITPAQAPLASPESLGSLTST 420
Query: 421 SEQAQLATSESLSPLTSLSGQAPLATGESLSDLPSTSEQARHSYGVRFNGFQADDSIIPT 480
SEQAQLATSESLSPLTSLSGQAPLATGESLSDLPSTSEQARHSYGVRFNGFQADDSIIPT
Sbjct: 421 SEQAQLATSESLSPLTSLSGQAPLATGESLSDLPSTSEQARHSYGVRFNGFQADDSIIPT 480
Query: 481 EIRNRVEAHGHGVTHDHEDSNESLSSDERHGHGPSGKPMLHHGEKGVQEAGWDLDDNNDK 540
EIRNRVEAHGHGVTHDHEDSNESLSSDERHGHGPSGKPMLHHGEKGVQEAGWDLDDNNDK
Sbjct: 481 EIRNRVEAHGHGVTHDHEDSNESLSSDERHGHGPSGKPMLHHGEKGVQEAGWDLDDNNDK 540
Query: 541 SDCLAIKEQFKCDTNSTWGLNDDELMAHGQEKDSSSESEDSCPPSPGCSFTEGFSFDLFN 600
SDCLAIKEQFKCDTNSTWGLNDDELMAHGQEKDSSSESEDSCPPSPGCSFTEGFSFDLFN
Sbjct: 541 SDCLAIKEQFKCDTNSTWGLNDDELMAHGQEKDSSSESEDSCPPSPGCSFTEGFSFDLFN 600
Query: 601 PDYVPKVDKWSRFLFPLAFGLFNIVYWVYHMY 632
PDYVPKVDKWSRFLFPLAFGLFNIVYWVYHMY
Sbjct: 601 PDYVPKVDKWSRFLFPLAFGLFNIVYWVYHMY 632
>gi|4503865 gamma-aminobutyric acid (GABA) A receptor, beta 2
isoform 2 [Homo sapiens]
Length = 474
Score = 370 bits (950), Expect = e-102
Identities = 162/310 (52%), Positives = 239/310 (77%)
Query: 54 ANEAVVQKILDRVLSRYDVRLRPNFGGAPVPVRISIYVTSIEQISEMNMDYTITMFFHQT 113
+N ++V++ +DR+L YD+RLRP+FGG PV V ++I + SI+ +SE+NMDYT+TM+F Q
Sbjct: 31 SNMSLVKETVDRLLKGYDIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMDYTLTMYFQQA 90
Query: 114 WKDSRLAYYETTLNLTLDYRMHEKLWVPDCYFLNSKDAFVHDVTVENRVFQLHPDGTVRY 173
W+D RL+Y LNLTLD R+ ++LWVPD YFLN K +FVH VTV+NR+ +LHPDGTV Y
Sbjct: 91 WRDKRLSYNVIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLY 150
Query: 174 GIRLTTTAACSLDLHKFPMDKQACNLVVESYGYTVEDIILFWDDNGNAIHMTEELHIPQF 233
G+R+TTTAAC +DL ++P+D+Q C L +ESYGYT +DI +W + NA+ ++ +PQF
Sbjct: 151 GLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGDDNAVTGVTKIELPQF 210
Query: 234 TFLGRTITSKEVYFYTGSYIRLILKFQVQREVNSYLVQVYWPTVLTTITSWISFWMNYDS 293
+ + + +K+V F TGSY RL L F+++R + +++Q Y P++L TI SW+SFW+NYD+
Sbjct: 211 SIVDYKLITKKVVFSTGSYPRLSLSFKLKRNIGYFILQTYMPSILITILSWVSFWINYDA 270
Query: 294 SAARVTIGLTSMLILTTIDSHLRDKLPNISCIKAIDIYILVCLFFVFLSLLEYVYINYLF 353
SAARV +G+T++L +TTI++HLR+ LP I +KAID+Y++ C FVF++LLEY +NY+F
Sbjct: 271 SAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFMALLEYALVNYIF 330
Query: 354 YSRGPRRQPR 363
+ RGP+RQ +
Sbjct: 331 FGRGPQRQKK 340
Score = 43.5 bits (101), Expect = 6e-04
Identities = 15/28 (53%), Positives = 21/28 (75%)
Query: 604 VPKVDKWSRFLFPLAFGLFNIVYWVYHM 631
V +D+WSR FP+ F FNIVYW+Y++
Sbjct: 446 VNAIDRWSRIFFPVVFSFFNIVYWLYYV 473
>gi|12548785 gamma-aminobutyric acid (GABA) A receptor, beta 2
isoform 1 [Homo sapiens]
Length = 512
Score = 370 bits (950), Expect = e-102
Identities = 162/310 (52%), Positives = 239/310 (77%)
Query: 54 ANEAVVQKILDRVLSRYDVRLRPNFGGAPVPVRISIYVTSIEQISEMNMDYTITMFFHQT 113
+N ++V++ +DR+L YD+RLRP+FGG PV V ++I + SI+ +SE+NMDYT+TM+F Q
Sbjct: 31 SNMSLVKETVDRLLKGYDIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMDYTLTMYFQQA 90
Query: 114 WKDSRLAYYETTLNLTLDYRMHEKLWVPDCYFLNSKDAFVHDVTVENRVFQLHPDGTVRY 173
W+D RL+Y LNLTLD R+ ++LWVPD YFLN K +FVH VTV+NR+ +LHPDGTV Y
Sbjct: 91 WRDKRLSYNVIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLY 150
Query: 174 GIRLTTTAACSLDLHKFPMDKQACNLVVESYGYTVEDIILFWDDNGNAIHMTEELHIPQF 233
G+R+TTTAAC +DL ++P+D+Q C L +ESYGYT +DI +W + NA+ ++ +PQF
Sbjct: 151 GLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGDDNAVTGVTKIELPQF 210
Query: 234 TFLGRTITSKEVYFYTGSYIRLILKFQVQREVNSYLVQVYWPTVLTTITSWISFWMNYDS 293
+ + + +K+V F TGSY RL L F+++R + +++Q Y P++L TI SW+SFW+NYD+
Sbjct: 211 SIVDYKLITKKVVFSTGSYPRLSLSFKLKRNIGYFILQTYMPSILITILSWVSFWINYDA 270
Query: 294 SAARVTIGLTSMLILTTIDSHLRDKLPNISCIKAIDIYILVCLFFVFLSLLEYVYINYLF 353
SAARV +G+T++L +TTI++HLR+ LP I +KAID+Y++ C FVF++LLEY +NY+F
Sbjct: 271 SAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFMALLEYALVNYIF 330
Query: 354 YSRGPRRQPR 363
+ RGP+RQ +
Sbjct: 331 FGRGPQRQKK 340
Score = 43.5 bits (101), Expect = 6e-04
Identities = 15/28 (53%), Positives = 21/28 (75%)
Query: 604 VPKVDKWSRFLFPLAFGLFNIVYWVYHM 631
V +D+WSR FP+ F FNIVYW+Y++
Sbjct: 484 VNAIDRWSRIFFPVVFSFFNIVYWLYYV 511
>gi|12548788 gamma-aminobutyric acid (GABA) A receptor, beta 3
isoform 2 precursor [Homo sapiens]
Length = 473
Score = 368 bits (945), Expect = e-102
Identities = 162/309 (52%), Positives = 235/309 (76%)
Query: 55 NEAVVQKILDRVLSRYDVRLRPNFGGAPVPVRISIYVTSIEQISEMNMDYTITMFFHQTW 114
N + V++ +D++L YD+RLRP+FGG PV V ++I + SI+ +SE+NMDYT+TM+F Q W
Sbjct: 33 NMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYW 92
Query: 115 KDSRLAYYETTLNLTLDYRMHEKLWVPDCYFLNSKDAFVHDVTVENRVFQLHPDGTVRYG 174
+D RLAY LNLTLD R+ ++LWVPD YFLN K +FVH VTV+NR+ +LHPDGTV YG
Sbjct: 93 RDKRLAYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYG 152
Query: 175 IRLTTTAACSLDLHKFPMDKQACNLVVESYGYTVEDIILFWDDNGNAIHMTEELHIPQFT 234
+R+TTTAAC +DL ++P+D+Q C L +ESYGYT +DI +W A+ E + +PQF+
Sbjct: 153 LRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFS 212
Query: 235 FLGRTITSKEVYFYTGSYIRLILKFQVQREVNSYLVQVYWPTVLTTITSWISFWMNYDSS 294
+ + S+ V F TG+Y RL L F+++R + +++Q Y P++L TI SW+SFW+NYD+S
Sbjct: 213 IVEHRLVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDAS 272
Query: 295 AARVTIGLTSMLILTTIDSHLRDKLPNISCIKAIDIYILVCLFFVFLSLLEYVYINYLFY 354
AARV +G+T++L +TTI++HLR+ LP I +KAID+Y++ C FVFL+LLEY ++NY+F+
Sbjct: 273 AARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFF 332
Query: 355 SRGPRRQPR 363
RGP+RQ +
Sbjct: 333 GRGPQRQKK 341
Score = 44.3 bits (103), Expect = 3e-04
Identities = 15/28 (53%), Positives = 22/28 (78%)
Query: 604 VPKVDKWSRFLFPLAFGLFNIVYWVYHM 631
V +D+WSR +FP F LFN+VYW+Y++
Sbjct: 445 VNAIDRWSRIVFPFTFSLFNLVYWLYYV 472
>gi|4503867 gamma-aminobutyric acid (GABA) A receptor, beta 3
isoform 1 precursor [Homo sapiens]
Length = 473
Score = 368 bits (945), Expect = e-102
Identities = 162/309 (52%), Positives = 235/309 (76%)
Query: 55 NEAVVQKILDRVLSRYDVRLRPNFGGAPVPVRISIYVTSIEQISEMNMDYTITMFFHQTW 114
N + V++ +D++L YD+RLRP+FGG PV V ++I + SI+ +SE+NMDYT+TM+F Q W
Sbjct: 33 NMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYW 92
Query: 115 KDSRLAYYETTLNLTLDYRMHEKLWVPDCYFLNSKDAFVHDVTVENRVFQLHPDGTVRYG 174
+D RLAY LNLTLD R+ ++LWVPD YFLN K +FVH VTV+NR+ +LHPDGTV YG
Sbjct: 93 RDKRLAYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYG 152
Query: 175 IRLTTTAACSLDLHKFPMDKQACNLVVESYGYTVEDIILFWDDNGNAIHMTEELHIPQFT 234
+R+TTTAAC +DL ++P+D+Q C L +ESYGYT +DI +W A+ E + +PQF+
Sbjct: 153 LRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFS 212
Query: 235 FLGRTITSKEVYFYTGSYIRLILKFQVQREVNSYLVQVYWPTVLTTITSWISFWMNYDSS 294
+ + S+ V F TG+Y RL L F+++R + +++Q Y P++L TI SW+SFW+NYD+S
Sbjct: 213 IVEHRLVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDAS 272
Query: 295 AARVTIGLTSMLILTTIDSHLRDKLPNISCIKAIDIYILVCLFFVFLSLLEYVYINYLFY 354
AARV +G+T++L +TTI++HLR+ LP I +KAID+Y++ C FVFL+LLEY ++NY+F+
Sbjct: 273 AARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFF 332
Query: 355 SRGPRRQPR 363
RGP+RQ +
Sbjct: 333 GRGPQRQKK 341
Score = 44.3 bits (103), Expect = 3e-04
Identities = 15/28 (53%), Positives = 22/28 (78%)
Query: 604 VPKVDKWSRFLFPLAFGLFNIVYWVYHM 631
V +D+WSR +FP F LFN+VYW+Y++
Sbjct: 445 VNAIDRWSRIVFPFTFSLFNLVYWLYYV 472
>gi|194097327 gamma-aminobutyric acid (GABA) A receptor, beta 1
precursor [Homo sapiens]
Length = 474
Score = 368 bits (944), Expect = e-101
Identities = 165/323 (51%), Positives = 241/323 (74%), Gaps = 4/323 (1%)
Query: 43 VVLNLFNCKNCANE----AVVQKILDRVLSRYDVRLRPNFGGAPVPVRISIYVTSIEQIS 98
V++ + C + NE + V++ +DR+L YD+RLRP+FGG PV V + I V SI+ +S
Sbjct: 17 VMITMVCCAHSTNEPSNMSYVKETVDRLLKGYDIRLRPDFGGPPVDVGMRIDVASIDMVS 76
Query: 99 EMNMDYTITMFFHQTWKDSRLAYYETTLNLTLDYRMHEKLWVPDCYFLNSKDAFVHDVTV 158
E+NMDYT+TM+F Q+WKD RL+Y LNLTLD R+ ++LWVPD YFLN K +FVH VTV
Sbjct: 77 EVNMDYTLTMYFQQSWKDKRLSYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTV 136
Query: 159 ENRVFQLHPDGTVRYGIRLTTTAACSLDLHKFPMDKQACNLVVESYGYTVEDIILFWDDN 218
+NR+ +LHPDGTV YG+R+TTTAAC +DL ++P+D+Q C L +ESYGYT +DI +W+
Sbjct: 137 KNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWNGG 196
Query: 219 GNAIHMTEELHIPQFTFLGRTITSKEVYFYTGSYIRLILKFQVQREVNSYLVQVYWPTVL 278
A+ ++ +PQF+ + + SK+V F TG+Y RL L F+++R + +++Q Y P+ L
Sbjct: 197 EGAVTGVNKIELPQFSIVDYKMVSKKVEFTTGAYPRLSLSFRLKRNIGYFILQTYMPSTL 256
Query: 279 TTITSWISFWMNYDSSAARVTIGLTSMLILTTIDSHLRDKLPNISCIKAIDIYILVCLFF 338
TI SW+SFW+NYD+SAARV +G+T++L +TTI +HLR+ LP I +KAIDIY++ C F
Sbjct: 257 ITILSWVSFWINYDASAARVALGITTVLTMTTISTHLRETLPKIPYVKAIDIYLMGCFVF 316
Query: 339 VFLSLLEYVYINYLFYSRGPRRQ 361
VFL+LLEY ++NY+F+ +GP+++
Sbjct: 317 VFLALLEYAFVNYIFFGKGPQKK 339
Score = 47.4 bits (111), Expect = 4e-05
Identities = 16/29 (55%), Positives = 23/29 (79%)
Query: 604 VPKVDKWSRFLFPLAFGLFNIVYWVYHMY 632
V +DKWSR FP+ F LFN+VYW+Y+++
Sbjct: 446 VNSIDKWSRMFFPITFSLFNVVYWLYYVH 474
>gi|34734071 gamma-aminobutyric acid (GABA) A receptor, delta
precursor [Homo sapiens]
Length = 452
Score = 278 bits (712), Expect = 8e-75
Identities = 132/308 (42%), Positives = 201/308 (65%), Gaps = 1/308 (0%)
Query: 63 LDRVLSRYDVRLRPNFGGAPVPVRISIYVTSIEQISEMNMDYTITMFFHQTWKDSRLAYY 122
LD +++ Y RP GG PV V +++ V SI+ ISE NM+YT+T+F HQ+W+DSRL+Y
Sbjct: 44 LDGLIAGYARNFRPGIGGPPVNVALALEVASIDHISEANMEYTMTVFLHQSWRDSRLSYN 103
Query: 123 ETTLNLTLDYRMHEKLWVPDCYFLNSKDAFVHDVTVENRVFQLHPDGTVRYGIRLTTTAA 182
T L LD R +KLW+PD + +N+K A+ HDVTVEN++ +L PDG + Y IR+T+T A
Sbjct: 104 HTNETLGLDSRFVDKLWLPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRITSTVA 163
Query: 183 CSLDLHKFPMDKQACNLVVESYGYTVEDIILFWDDNGNAIHMTEELHIPQFTFLGRTITS 242
C +DL K+PMD+Q C L +ESYGY+ EDI+ +W ++ IH ++L + QFT T+
Sbjct: 164 CDMDLAKYPMDEQECMLDLESYGYSSEDIVYYWSESQEHIHGLDKLQLAQFTITSYRFTT 223
Query: 243 KEVYFYT-GSYIRLILKFQVQREVNSYLVQVYWPTVLTTITSWISFWMNYDSSAARVTIG 301
+ + F + G + RL L F ++R Y++Q Y P+VL SW+SFW++ + ARV++G
Sbjct: 224 ELMNFKSAGQFPRLSLHFHLRRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPARVSLG 283
Query: 302 LTSMLILTTIDSHLRDKLPNISCIKAIDIYILVCLFFVFLSLLEYVYINYLFYSRGPRRQ 361
+T++L +TT+ R LP S IKA+D+Y +C FVF +L+EY + ++ R ++
Sbjct: 284 ITTVLTMTTLMVSARSSLPRASAIKALDVYFWICYVFVFAALVEYAFAHFNADYRKKQKA 343
Query: 362 PRRHRRPR 369
+ RPR
Sbjct: 344 KVKVSRPR 351
>gi|119372310 glycine receptor, alpha 1 isoform 2 precursor [Homo
sapiens]
Length = 449
Score = 263 bits (672), Expect = 4e-70
Identities = 141/368 (38%), Positives = 216/368 (58%), Gaps = 15/368 (4%)
Query: 63 LDRVLSR---YDVRLRPNFGGAPVPVRISIYVTSIEQISEMNMDYTITMFFHQTWKDSRL 119
LD+++ R YD R+RPNF G PV V +I++ S I+E MDY + +F Q W D RL
Sbjct: 42 LDKLMGRTSGYDARIRPNFKGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRL 101
Query: 120 AYYE-TTLNLTLDYRMHEKLWVPDCYFLNSKDAFVHDVTVENRVFQLHPDGTVRYGIRLT 178
AY E +L LD M + +W PD +F N K A H++T +N++ ++ +G V Y IR+T
Sbjct: 102 AYNEYPDDSLDLDPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRIT 161
Query: 179 TTAACSLDLHKFPMDKQACNLVVESYGYTVEDIILFWDDNGNAIHMTEELHIPQFTFLG- 237
T AC +DL FPMD Q C + +ES+GYT+ D+I W + G A+ + + L +PQF
Sbjct: 162 LTLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQEQG-AVQVADGLTLPQFILKEE 220
Query: 238 RTITSKEVYFYTGSYIRLILKFQVQREVNSYLVQVYWPTVLTTITSWISFWMNYDSSAAR 297
+ + ++ TG + + +F ++R++ YL+Q+Y P++L I SWISFW+N D++ AR
Sbjct: 221 KDLRYCTKHYNTGKFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPAR 280
Query: 298 VTIGLTSMLILTTIDSHLRDKLPNISCIKAIDIYILVCLFFVFLSLLEYVYINYLFYSRG 357
V +G+T++L +TT S R LP +S +KAIDI++ VCL FVF +LLEY +N++
Sbjct: 281 VGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHK 340
Query: 358 P----RRQPRRHRRPRRVIARYRYQQVVVG----NVQDGLINVEDGVSSLPITPAQAPLA 409
RR+ R H+ R+ + +G +DG I+V+ +S P AP
Sbjct: 341 ELLRFRRKRRHHKEDEAGEGRFNFSAYGMGPACLQAKDG-ISVKGANNSNTTNPPPAPSK 399
Query: 410 SPESLGSL 417
SPE + L
Sbjct: 400 SPEEMRKL 407
Score = 35.8 bits (81), Expect = 0.12
Identities = 19/59 (32%), Positives = 32/59 (54%), Gaps = 3/59 (5%)
Query: 572 KDSSSESEDSCPPSPGCSFTEGFSFDLFNPDYVPKVDKWSRFLFPLAFGLFNIVYWVYH 630
K +++ + + PP+P S E + K+DK SR FP+AF +FN+ YW+ +
Sbjct: 383 KGANNSNTTNPPPAPSKSPEEMRKLFI---QRAKKIDKISRIGFPMAFLIFNMFYWIIY 438
>gi|194097386 gamma-aminobutyric acid (GABA) receptor, rho 1 [Homo
sapiens]
Length = 479
Score = 262 bits (669), Expect = 8e-70
Identities = 124/324 (38%), Positives = 202/324 (62%), Gaps = 2/324 (0%)
Query: 70 YDVRLRPNFGGAPVPVRISIYVTSIEQISEMNMDYTITMFFHQTWKDSRLAYYETT-LNL 128
+D +RP FGG +PV + + V S++ ISE++MD+T+T++ WKD RL++ T L++
Sbjct: 84 HDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNNLSM 143
Query: 129 TLDYRMHEKLWVPDCYFLNSKDAFVHDVTVENRVFQLHPDGTVRYGIRLTTTAACSLDLH 188
T D R+ +K+WVPD +F++SK +F+HD T +N + ++ PDG V Y +R+T TA C++D
Sbjct: 144 TFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNMDFS 203
Query: 189 KFPMDKQACNLVVESYGYTVEDIILFWDDNGNAIHMTEELHIPQFTFLG-RTITSKEVYF 247
+FP+D Q C+L +ESY YT +D++L+W +++ E + + QF T T Y
Sbjct: 204 RFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYS 263
Query: 248 YTGSYIRLILKFQVQREVNSYLVQVYWPTVLTTITSWISFWMNYDSSAARVTIGLTSMLI 307
TG Y RL + F ++R + +L+Q Y+P L + SW+SFW++ + ARV +G+T++L
Sbjct: 264 STGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLT 323
Query: 308 LTTIDSHLRDKLPNISCIKAIDIYILVCLFFVFLSLLEYVYINYLFYSRGPRRQPRRHRR 367
++TI + + +P +S IKA+DIY+ V FVFLS+LEY +NYL + + Q R +
Sbjct: 324 MSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKEQKLREKL 383
Query: 368 PRRVIARYRYQQVVVGNVQDGLIN 391
P ++ GN DG +N
Sbjct: 384 PCTSGLPPPRTAMLDGNYSDGEVN 407
Score = 35.8 bits (81), Expect = 0.12
Identities = 12/21 (57%), Positives = 18/21 (85%)
Query: 607 VDKWSRFLFPLAFGLFNIVYW 627
+DK+SR +FP A+ LFN++YW
Sbjct: 455 IDKYSRIIFPAAYILFNLIYW 475
>gi|225903367 glycine receptor, alpha 1 isoform 1 precursor [Homo
sapiens]
Length = 457
Score = 259 bits (663), Expect = 4e-69
Identities = 142/376 (37%), Positives = 218/376 (57%), Gaps = 23/376 (6%)
Query: 63 LDRVLSR---YDVRLRPNFGGAPVPVRISIYVTSIEQISEMNMDYTITMFFHQTWKDSRL 119
LD+++ R YD R+RPNF G PV V +I++ S I+E MDY + +F Q W D RL
Sbjct: 42 LDKLMGRTSGYDARIRPNFKGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRL 101
Query: 120 AYYE-TTLNLTLDYRMHEKLWVPDCYFLNSKDAFVHDVTVENRVFQLHPDGTVRYGIRLT 178
AY E +L LD M + +W PD +F N K A H++T +N++ ++ +G V Y IR+T
Sbjct: 102 AYNEYPDDSLDLDPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRIT 161
Query: 179 TTAACSLDLHKFPMDKQACNLVVESYGYTVEDIILFWDDNGNAIHMTEELHIPQFTFLG- 237
T AC +DL FPMD Q C + +ES+GYT+ D+I W + G A+ + + L +PQF
Sbjct: 162 LTLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQEQG-AVQVADGLTLPQFILKEE 220
Query: 238 RTITSKEVYFYTGSYIRLILKFQVQREVNSYLVQVYWPTVLTTITSWISFWMNYDSSAAR 297
+ + ++ TG + + +F ++R++ YL+Q+Y P++L I SWISFW+N D++ AR
Sbjct: 221 KDLRYCTKHYNTGKFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPAR 280
Query: 298 VTIGLTSMLILTTIDSHLRDKLPNISCIKAIDIYILVCLFFVFLSLLEYVYINYLFYSRG 357
V +G+T++L +TT S R LP +S +KAIDI++ VCL FVF +LLEY +N++
Sbjct: 281 VGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHK 340
Query: 358 P----RRQPRRHRRPRRVI--------ARYRYQQVVVG----NVQDGLINVEDGVSSLPI 401
RR+ R H+ P + R+ + +G +DG I+V+ +S
Sbjct: 341 ELLRFRRKRRHHKSPMLNLFQEDEAGEGRFNFSAYGMGPACLQAKDG-ISVKGANNSNTT 399
Query: 402 TPAQAPLASPESLGSL 417
P AP SPE + L
Sbjct: 400 NPPPAPSKSPEEMRKL 415
Score = 35.8 bits (81), Expect = 0.12
Identities = 19/59 (32%), Positives = 32/59 (54%), Gaps = 3/59 (5%)
Query: 572 KDSSSESEDSCPPSPGCSFTEGFSFDLFNPDYVPKVDKWSRFLFPLAFGLFNIVYWVYH 630
K +++ + + PP+P S E + K+DK SR FP+AF +FN+ YW+ +
Sbjct: 391 KGANNSNTTNPPPAPSKSPEEMRKLFI---QRAKKIDKISRIGFPMAFLIFNMFYWIIY 446
>gi|169646728 glycine receptor, alpha 2 isoform B [Homo sapiens]
Length = 452
Score = 259 bits (662), Expect = 5e-69
Identities = 142/362 (39%), Positives = 214/362 (59%), Gaps = 14/362 (3%)
Query: 63 LDRVLSR---YDVRLRPNFGGAPVPVRISIYVTSIEQISEMNMDYTITMFFHQTWKDSRL 119
LD+++ R YD R+RPNF G PV V +I++ S I+E MDY + +F Q W DSRL
Sbjct: 48 LDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSIAETTMDYRVNIFLRQQWNDSRL 107
Query: 120 AYYE-TTLNLTLDYRMHEKLWVPDCYFLNSKDAFVHDVTVENRVFQLHPDGTVRYGIRLT 178
AY E +L LD M + +W PD +F N K A HDVT +N++ ++ +G V Y IRLT
Sbjct: 108 AYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLT 167
Query: 179 TTAACSLDLHKFPMDKQACNLVVESYGYTVEDIILFWDDNGNAIHMTEELHIPQFTFLG- 237
T +C +DL FPMD Q C + +ES+GYT+ D+I W +G + + E L +PQF
Sbjct: 168 LTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWLSDG-PVQVAEGLTLPQFILKEE 226
Query: 238 RTITSKEVYFYTGSYIRLILKFQVQREVNSYLVQVYWPTVLTTITSWISFWMNYDSSAAR 297
+ + ++ TG + + +KF ++R++ YL+Q+Y P++L I SW+SFW+N D++ AR
Sbjct: 227 KELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPAR 286
Query: 298 VTIGLTSMLILTTIDSHLRDKLPNISCIKAIDIYILVCLFFVFLSLLEYVYINYLFYSRG 357
V +G+T++L +TT S R LP +S +KAIDI++ VCL FVF +LLEY +N++
Sbjct: 287 VALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQHK 346
Query: 358 P----RRQPRRHRRPRRVIARYRYQQVVVGNVQDGLINVEDGVSSLPITPAQAPLASPES 413
RR+ +R + V R+ G + V+DG +++ TPA PL P
Sbjct: 347 EFLRLRRRQKRQNKEEDVTRESRFN--FSGYGMGHCLQVKDG-TAVKATPAN-PLPQPPK 402
Query: 414 LG 415
G
Sbjct: 403 DG 404
Score = 35.0 bits (79), Expect = 0.21
Identities = 18/46 (39%), Positives = 24/46 (52%), Gaps = 6/46 (13%)
Query: 583 PPSPGCSFTEGFSFDLFNPDYVPKVDKWSRFLFPLAFGLFNIVYWV 628
PP G + + F D ++D SR FPLAF +FNI YW+
Sbjct: 400 PPKDGDAIKKKFV------DRAKRIDTISRAAFPLAFLIFNIFYWI 439
>gi|169646723 glycine receptor, alpha 2 isoform A [Homo sapiens]
Length = 452
Score = 259 bits (661), Expect = 7e-69
Identities = 141/362 (38%), Positives = 214/362 (59%), Gaps = 14/362 (3%)
Query: 63 LDRVLSR---YDVRLRPNFGGAPVPVRISIYVTSIEQISEMNMDYTITMFFHQTWKDSRL 119
LD+++ R YD R+RPNF G PV V +I++ S ++E MDY + +F Q W DSRL
Sbjct: 48 LDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRL 107
Query: 120 AYYE-TTLNLTLDYRMHEKLWVPDCYFLNSKDAFVHDVTVENRVFQLHPDGTVRYGIRLT 178
AY E +L LD M + +W PD +F N K A HDVT +N++ ++ +G V Y IRLT
Sbjct: 108 AYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLT 167
Query: 179 TTAACSLDLHKFPMDKQACNLVVESYGYTVEDIILFWDDNGNAIHMTEELHIPQFTFLG- 237
T +C +DL FPMD Q C + +ES+GYT+ D+I W +G + + E L +PQF
Sbjct: 168 LTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWLSDG-PVQVAEGLTLPQFILKEE 226
Query: 238 RTITSKEVYFYTGSYIRLILKFQVQREVNSYLVQVYWPTVLTTITSWISFWMNYDSSAAR 297
+ + ++ TG + + +KF ++R++ YL+Q+Y P++L I SW+SFW+N D++ AR
Sbjct: 227 KELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPAR 286
Query: 298 VTIGLTSMLILTTIDSHLRDKLPNISCIKAIDIYILVCLFFVFLSLLEYVYINYLFYSRG 357
V +G+T++L +TT S R LP +S +KAIDI++ VCL FVF +LLEY +N++
Sbjct: 287 VALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQHK 346
Query: 358 P----RRQPRRHRRPRRVIARYRYQQVVVGNVQDGLINVEDGVSSLPITPAQAPLASPES 413
RR+ +R + V R+ G + V+DG +++ TPA PL P
Sbjct: 347 EFLRLRRRQKRQNKEEDVTRESRFN--FSGYGMGHCLQVKDG-TAVKATPAN-PLPQPPK 402
Query: 414 LG 415
G
Sbjct: 403 DG 404
Score = 35.0 bits (79), Expect = 0.21
Identities = 18/46 (39%), Positives = 24/46 (52%), Gaps = 6/46 (13%)
Query: 583 PPSPGCSFTEGFSFDLFNPDYVPKVDKWSRFLFPLAFGLFNIVYWV 628
PP G + + F D ++D SR FPLAF +FNI YW+
Sbjct: 400 PPKDGDAIKKKFV------DRAKRIDTISRAAFPLAFLIFNIFYWI 439
>gi|4504021 glycine receptor, alpha 2 isoform A [Homo sapiens]
Length = 452
Score = 259 bits (661), Expect = 7e-69
Identities = 141/362 (38%), Positives = 214/362 (59%), Gaps = 14/362 (3%)
Query: 63 LDRVLSR---YDVRLRPNFGGAPVPVRISIYVTSIEQISEMNMDYTITMFFHQTWKDSRL 119
LD+++ R YD R+RPNF G PV V +I++ S ++E MDY + +F Q W DSRL
Sbjct: 48 LDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRL 107
Query: 120 AYYE-TTLNLTLDYRMHEKLWVPDCYFLNSKDAFVHDVTVENRVFQLHPDGTVRYGIRLT 178
AY E +L LD M + +W PD +F N K A HDVT +N++ ++ +G V Y IRLT
Sbjct: 108 AYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLT 167
Query: 179 TTAACSLDLHKFPMDKQACNLVVESYGYTVEDIILFWDDNGNAIHMTEELHIPQFTFLG- 237
T +C +DL FPMD Q C + +ES+GYT+ D+I W +G + + E L +PQF
Sbjct: 168 LTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWLSDG-PVQVAEGLTLPQFILKEE 226
Query: 238 RTITSKEVYFYTGSYIRLILKFQVQREVNSYLVQVYWPTVLTTITSWISFWMNYDSSAAR 297
+ + ++ TG + + +KF ++R++ YL+Q+Y P++L I SW+SFW+N D++ AR
Sbjct: 227 KELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPAR 286
Query: 298 VTIGLTSMLILTTIDSHLRDKLPNISCIKAIDIYILVCLFFVFLSLLEYVYINYLFYSRG 357
V +G+T++L +TT S R LP +S +KAIDI++ VCL FVF +LLEY +N++
Sbjct: 287 VALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQHK 346
Query: 358 P----RRQPRRHRRPRRVIARYRYQQVVVGNVQDGLINVEDGVSSLPITPAQAPLASPES 413
RR+ +R + V R+ G + V+DG +++ TPA PL P
Sbjct: 347 EFLRLRRRQKRQNKEEDVTRESRFN--FSGYGMGHCLQVKDG-TAVKATPAN-PLPQPPK 402
Query: 414 LG 415
G
Sbjct: 403 DG 404
Score = 35.0 bits (79), Expect = 0.21
Identities = 18/46 (39%), Positives = 24/46 (52%), Gaps = 6/46 (13%)
Query: 583 PPSPGCSFTEGFSFDLFNPDYVPKVDKWSRFLFPLAFGLFNIVYWV 628
PP G + + F D ++D SR FPLAF +FNI YW+
Sbjct: 400 PPKDGDAIKKKFV------DRAKRIDTISRAAFPLAFLIFNIFYWI 439
>gi|157743288 gamma-aminobutyric acid (GABA) receptor, rho 3 [Homo
sapiens]
Length = 467
Score = 257 bits (656), Expect = 3e-68
Identities = 117/285 (41%), Positives = 191/285 (67%), Gaps = 4/285 (1%)
Query: 71 DVRLRPNFGGAPVPVRISIYVTSIEQISEMNMDYTITMFFHQTWKDSRLAYYETT-LNLT 129
D +RP FGG+PVPV I ++V SI+ ISE NMD+T+T + WKD RL++ T ++T
Sbjct: 71 DFAMRPGFGGSPVPVGIDVHVESIDSISETNMDFTMTFYLRHYWKDERLSFPSTANKSMT 130
Query: 130 LDYRMHEKLWVPDCYFLNSKDAFVHDVTVENRVFQLHPDGTVRYGIRLTTTAACSLDLHK 189
D+R+ K+WVPD +F++SK +F+HD T+EN + ++HPDG V +R+T +A C +D +
Sbjct: 131 FDHRLTRKIWVPDIFFVHSKRSFIHDTTMENIMLRVHPDGNVLLSLRITVSAMCFMDFSR 190
Query: 190 FPMDKQACNLVVESYGYTVEDIILFWDDNGNAIHMTEELHIPQFTFLGRTITSKEVYFY- 248
FP+D Q C+L +ESY Y +D++L+W +++ E + + QF F+ S + FY
Sbjct: 191 FPLDTQNCSLELESYAYNEDDLMLYWKHGNKSLNTEEHMSLSQF-FIEDFSASSGLAFYS 249
Query: 249 -TGSYIRLILKFQVQREVNSYLVQVYWPTVLTTITSWISFWMNYDSSAARVTIGLTSMLI 307
TG Y RL + F ++R V +++Q Y+P +L + SW+SFW++ + ARV++G+T++L
Sbjct: 250 STGWYNRLFINFVLRRHVFFFVLQTYFPAILMVMLSWVSFWIDRRAVPARVSLGITTVLT 309
Query: 308 LTTIDSHLRDKLPNISCIKAIDIYILVCLFFVFLSLLEYVYINYL 352
++TI + + +P +S +KA+D+Y+ V FVFLS++EY +NYL
Sbjct: 310 MSTIITAVSASMPQVSYLKAVDVYLWVSSLFVFLSVIEYAAVNYL 354
Score = 32.3 bits (72), Expect = 1.4
Identities = 11/21 (52%), Positives = 16/21 (76%)
Query: 607 VDKWSRFLFPLAFGLFNIVYW 627
+D +SR LFP+ + LFN+ YW
Sbjct: 443 IDTYSRILFPIVYILFNLFYW 463
>gi|218156328 glycine receptor, alpha 4 precursor [Homo sapiens]
Length = 417
Score = 255 bits (651), Expect = 1e-67
Identities = 129/313 (41%), Positives = 196/313 (62%), Gaps = 7/313 (2%)
Query: 63 LDRVLSR---YDVRLRPNFGGAPVPVRISIYVTSIEQISEMNMDYTITMFFHQTWKDSRL 119
LD+++ R YD R+RPNF G PV V +I++ S I++ MDY + +F Q W D RL
Sbjct: 48 LDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFSSITKTTMDYRVNVFLRQQWNDPRL 107
Query: 120 AYYE-TTLNLTLDYRMHEKLWVPDCYFLNSKDAFVHDVTVENRVFQLHPDGTVRYGIRLT 178
+Y E +L LD M + +W PD +F N K A H+VT +N++ ++ +G V Y IRLT
Sbjct: 108 SYREYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLT 167
Query: 179 TTAACSLDLHKFPMDKQACNLVVESYGYTVEDIILFWDDNGNAIHMTEELHIPQFTFLG- 237
+C +DL FPMD Q C + +ES+GYT++D++ W ++ A+ + E L +PQF
Sbjct: 168 LILSCLMDLKNFPMDIQTCTMQLESFGYTMKDLVFEWLEDAPAVQVAEGLTLPQFILRDE 227
Query: 238 RTITSKEVYFYTGSYIRLILKFQVQREVNSYLVQVYWPTVLTTITSWISFWMNYDSSAAR 297
+ + ++ TG + + +KF ++R++ YL+Q+Y P++L I SW+SFW+N D++ AR
Sbjct: 228 KDLGCCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPAR 287
Query: 298 VTIGLTSMLILTTIDSHLRDKLPNISCIKAIDIYILVCLFFVFLSLLEYVYINYLFYSRG 357
V +G+T++L +TT S R LP +S +KAIDI++ VCL FVF +LLEY IN F SR
Sbjct: 288 VGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAIN--FVSRQ 345
Query: 358 PRRQPRRHRRPRR 370
+ R RR RR
Sbjct: 346 HKEFIRLRRRQRR 358
>gi|153266866 gamma-aminobutyric acid (GABA) receptor, rho 2
precursor [Homo sapiens]
Length = 490
Score = 254 bits (649), Expect = 2e-67
Identities = 118/305 (38%), Positives = 198/305 (64%), Gaps = 4/305 (1%)
Query: 67 LSRYDVRLRPNFGGAPVPVRISIYVTSIEQISEMNMDYTITMFFHQTWKDSRLAYYETT- 125
+ +D +RP FGG +PV + + V S++ ISE++MD+T+T++ WKD RLA+ +
Sbjct: 86 VDEHDFSMRPAFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLAFSSASN 145
Query: 126 LNLTLDYRMHEKLWVPDCYFLNSKDAFVHDVTVENRVFQLHPDGTVRYGIRLTTTAACSL 185
++T D R+ +K+WVPD +F++SK +F HD T +N + ++ PDG V Y +R+T TA C++
Sbjct: 146 KSMTFDGRLVKKIWVPDVFFVHSKRSFTHDTTTDNIMLRVFPDGHVLYSMRITVTAMCNM 205
Query: 186 DLHKFPMDKQACNLVVESYGYTVEDIILFWDDNGNAIHMTEELHIPQFTFLGRTITSKEV 245
D FP+D Q C+L +ESY YT ED++L+W + ++ E++ + QF + + T+ +
Sbjct: 206 DFSHFPLDSQTCSLELESYAYTDEDLMLYWKNGDESLKTDEKISLSQF-LIQKFHTTSRL 264
Query: 246 YFY--TGSYIRLILKFQVQREVNSYLVQVYWPTVLTTITSWISFWMNYDSSAARVTIGLT 303
FY TG Y RL + F ++R + +L+Q Y+P L + SW+SFW++ + ARV++G+T
Sbjct: 265 AFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVSLGIT 324
Query: 304 SMLILTTIDSHLRDKLPNISCIKAIDIYILVCLFFVFLSLLEYVYINYLFYSRGPRRQPR 363
++L +TTI + + +P +S +KA+DIY+ V FVFLS+LEY +NYL + + +
Sbjct: 325 TVLTMTTIITGVNASMPRVSYVKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKERKL 384
Query: 364 RHRRP 368
R + P
Sbjct: 385 REKFP 389
Score = 33.1 bits (74), Expect = 0.80
Identities = 10/21 (47%), Positives = 17/21 (80%)
Query: 607 VDKWSRFLFPLAFGLFNIVYW 627
+DK+SR +FP ++ FN++YW
Sbjct: 466 IDKYSRLIFPASYIFFNLIYW 486
>gi|110347433 glycine receptor, alpha 3 isoform b [Homo sapiens]
Length = 449
Score = 251 bits (642), Expect = 1e-66
Identities = 135/359 (37%), Positives = 210/359 (58%), Gaps = 10/359 (2%)
Query: 63 LDRVLSR---YDVRLRPNFGGAPVPVRISIYVTSIEQISEMNMDYTITMFFHQTWKDSRL 119
LD+++ R YD R+RPNF G PV V +I++ S I+E MDY + +F Q W D RL
Sbjct: 47 LDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRL 106
Query: 120 AYYE-TTLNLTLDYRMHEKLWVPDCYFLNSKDAFVHDVTVENRVFQLHPDGTVRYGIRLT 178
AY E +L LD M + +W PD +F N K A H+VT +N++ ++ +G V Y IRLT
Sbjct: 107 AYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLT 166
Query: 179 TTAACSLDLHKFPMDKQACNLVVESYGYTVEDIILFWDDNGNAIHMTEELHIPQFTFLG- 237
T +C +DL FPMD Q C + +ES+GYT+ D+I W D + + E L +PQF
Sbjct: 167 LTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQDEA-PVQVAEGLTLPQFLLKEE 225
Query: 238 RTITSKEVYFYTGSYIRLILKFQVQREVNSYLVQVYWPTVLTTITSWISFWMNYDSSAAR 297
+ + ++ TG + + ++F ++R++ YL+Q+Y P++L I SW+SFW+N D++ AR
Sbjct: 226 KDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPAR 285
Query: 298 VTIGLTSMLILTTIDSHLRDKLPNISCIKAIDIYILVCLFFVFLSLLEYVYINYLFYSRG 357
V +G+T++L +TT S R LP +S +KAIDI++ VCL FVF +LLEY +N++
Sbjct: 286 VALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHK 345
Query: 358 PRRQPRRHRRPR-RVIARYRYQQVVVGNVQDGLINVEDGVSSL-PITPAQAPLASPESL 414
+ RR R+ + + R+ G + +DG++ P P Q SP+ +
Sbjct: 346 ELLRFRRKRKNKDDEVRESRFSFTAYG--MGPCLQAKDGMTPKGPNHPVQVMPKSPDEM 402
Score = 36.2 bits (82), Expect = 0.094
Identities = 16/29 (55%), Positives = 19/29 (65%)
Query: 602 DYVPKVDKWSRFLFPLAFGLFNIVYWVYH 630
D K+D SR FPLAF +FNI YWV +
Sbjct: 408 DRAKKIDTISRACFPLAFLIFNIFYWVIY 436
>gi|110347441 glycine receptor, alpha 3 isoform a [Homo sapiens]
Length = 464
Score = 251 bits (641), Expect = 1e-66
Identities = 130/313 (41%), Positives = 195/313 (62%), Gaps = 9/313 (2%)
Query: 63 LDRVLSR---YDVRLRPNFGGAPVPVRISIYVTSIEQISEMNMDYTITMFFHQTWKDSRL 119
LD+++ R YD R+RPNF G PV V +I++ S I+E MDY + +F Q W D RL
Sbjct: 47 LDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRL 106
Query: 120 AYYE-TTLNLTLDYRMHEKLWVPDCYFLNSKDAFVHDVTVENRVFQLHPDGTVRYGIRLT 178
AY E +L LD M + +W PD +F N K A H+VT +N++ ++ +G V Y IRLT
Sbjct: 107 AYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLT 166
Query: 179 TTAACSLDLHKFPMDKQACNLVVESYGYTVEDIILFWDDNGNAIHMTEELHIPQFTFLG- 237
T +C +DL FPMD Q C + +ES+GYT+ D+I W D + + E L +PQF
Sbjct: 167 LTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQDEA-PVQVAEGLTLPQFLLKEE 225
Query: 238 RTITSKEVYFYTGSYIRLILKFQVQREVNSYLVQVYWPTVLTTITSWISFWMNYDSSAAR 297
+ + ++ TG + + ++F ++R++ YL+Q+Y P++L I SW+SFW+N D++ AR
Sbjct: 226 KDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPAR 285
Query: 298 VTIGLTSMLILTTIDSHLRDKLPNISCIKAIDIYILVCLFFVFLSLLEYVYINYLFYSRG 357
V +G+T++L +TT S R LP +S +KAIDI++ VCL FVF +LLEY +N F SR
Sbjct: 286 VALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVN--FVSR- 342
Query: 358 PRRQPRRHRRPRR 370
++ R RR R+
Sbjct: 343 QHKELLRFRRKRK 355
Score = 36.2 bits (82), Expect = 0.094
Identities = 16/29 (55%), Positives = 19/29 (65%)
Query: 602 DYVPKVDKWSRFLFPLAFGLFNIVYWVYH 630
D K+D SR FPLAF +FNI YWV +
Sbjct: 423 DRAKKIDTISRACFPLAFLIFNIFYWVIY 451
>gi|7657106 gamma-aminobutyric acid (GABA) A receptor, pi [Homo
sapiens]
Length = 440
Score = 251 bits (640), Expect = 2e-66
Identities = 123/289 (42%), Positives = 183/289 (63%), Gaps = 2/289 (0%)
Query: 64 DRVLSRYDVRLRPNFGGAPVPVRISIYVTSIEQISEMNMDYTITMFFHQTWKDSRLAYYE 123
+ + + Y+ LRPNFGG PV + +++ + SI ISE NMDYT T++ Q W D RL + E
Sbjct: 42 ENLTAGYNKFLRPNFGGEPVQIALTLDIASISSISESNMDYTATIYLRQRWMDQRLVF-E 100
Query: 124 TTLNLTLDYRMHEKLWVPDCYFLNSKDAFVHDVTVENRVFQLHPDGTVRYGIRLTTTAAC 183
+ TLD R+ E LWVPD Y + SK +F+H+VTV NR+ +L +GTV Y +R+TTT AC
Sbjct: 101 GNKSFTLDARLVEFLWVPDTYIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVAC 160
Query: 184 SLDLHKFPMDKQACNLVVESYGYTVEDIILFWDDNGNAIHMTEELHIPQFTFLGRTITSK 243
++DL K+PMD Q C L +ES+GY D+ W +++ E L + Q+T
Sbjct: 161 NMDLSKYPMDTQTCKLQLESWGYDGNDVEFTWLRGNDSVRGLEHLRLAQYTIERYFTLVT 220
Query: 244 EVYFYTGSYIRLILKFQVQREVNSYLVQVYWPTVLTTITSWISFWMNYDSSAARVTIGLT 303
TG+Y RL+L+F+++R V ++++ Y P+ + SW+SFW++ DS AR IG+T
Sbjct: 221 RSQQETGNYTRLVLQFELRRNVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCIGVT 280
Query: 304 SMLILTTIDSHLRDKLPNISC-IKAIDIYILVCLFFVFLSLLEYVYINY 351
++L +TT+ R LPN +C IKAID+Y+ +C FVF +LLEY +Y
Sbjct: 281 TVLSMTTLMIGSRTSLPNTNCFIKAIDVYLGICFSFVFGALLEYAVAHY 329
Score = 40.0 bits (92), Expect = 0.007
Identities = 17/36 (47%), Positives = 21/36 (58%)
Query: 597 DLFNPDYVPKVDKWSRFLFPLAFGLFNIVYWVYHMY 632
D F VD +S+ LFPL F L N+ YW Y+MY
Sbjct: 404 DYFTIQNPSNVDHYSKLLFPLIFMLANVFYWAYYMY 439
>gi|110347416 gamma-aminobutyric acid (GABA) A receptor, gamma 3
[Homo sapiens]
Length = 467
Score = 246 bits (628), Expect = 5e-65
Identities = 117/300 (39%), Positives = 179/300 (59%)
Query: 59 VQKILDRVLSRYDVRLRPNFGGAPVPVRISIYVTSIEQISEMNMDYTITMFFHQTWKDSR 118
V IL+++L YD +LRP+ G P + + IYV SI +S +NM+Y I +FF QTW DSR
Sbjct: 47 VTLILNKLLREYDKKLRPDIGIKPTVIDVDIYVNSIGPVSSINMEYQIDIFFAQTWTDSR 106
Query: 119 LAYYETTLNLTLDYRMHEKLWVPDCYFLNSKDAFVHDVTVENRVFQLHPDGTVRYGIRLT 178
L + T LTL+ M +W+PD F NSK A H +T N++ ++ DG + Y +RLT
Sbjct: 107 LRFNSTMKILTLNSNMVGLIWIPDTIFRNSKTAEAHWITTPNQLLRIWNDGKILYTLRLT 166
Query: 179 TTAACSLDLHKFPMDKQACNLVVESYGYTVEDIILFWDDNGNAIHMTEELHIPQFTFLGR 238
A C L LH FPMD+ +C L+ SYGY E++I W N + + QF F+G
Sbjct: 167 INAECQLQLHNFPMDEHSCPLIFSSYGYPKEEMIYRWRKNSVEAADQKSWRLYQFDFMGL 226
Query: 239 TITSKEVYFYTGSYIRLILKFQVQREVNSYLVQVYWPTVLTTITSWISFWMNYDSSAARV 298
T++ V G Y+ + + F++ R + + +Q Y P +LT + SW+SFW+ D++ AR
Sbjct: 227 RNTTEIVTTSAGDYVVMTIYFELSRRMGYFTIQTYIPCILTVVLSWVSFWIKKDATPART 286
Query: 299 TIGLTSMLILTTIDSHLRDKLPNISCIKAIDIYILVCLFFVFLSLLEYVYINYLFYSRGP 358
+G+T++L +TT+ + R LP +S + A+D+++ VC FVF +L+EY +NY R P
Sbjct: 287 ALGITTVLTMTTLSTIARKSLPRVSYVTAMDLFVTVCFLFVFAALMEYATLNYYSSCRKP 346
Score = 37.4 bits (85), Expect = 0.042
Identities = 14/27 (51%), Positives = 21/27 (77%)
Query: 606 KVDKWSRFLFPLAFGLFNIVYWVYHMY 632
++D +SR FP +F LFN+VYWV ++Y
Sbjct: 440 ELDSYSRVFFPTSFLLFNLVYWVGYLY 466
>gi|38788135 gamma-aminobutyric acid A receptor, gamma 2 isoform 2
precursor [Homo sapiens]
Length = 467
Score = 241 bits (616), Expect = 1e-63
Identities = 117/312 (37%), Positives = 184/312 (58%)
Query: 56 EAVVQKILDRVLSRYDVRLRPNFGGAPVPVRISIYVTSIEQISEMNMDYTITMFFHQTWK 115
E V IL+ +L YD +LRP+ G P + +YV SI ++ +NM+YTI +FF QTW
Sbjct: 63 EGDVTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWY 122
Query: 116 DSRLAYYETTLNLTLDYRMHEKLWVPDCYFLNSKDAFVHDVTVENRVFQLHPDGTVRYGI 175
D RL + T L L+ M K+W+PD +F NSK A H +T NR+ ++ DG V Y +
Sbjct: 123 DRRLKFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTL 182
Query: 176 RLTTTAACSLDLHKFPMDKQACNLVVESYGYTVEDIILFWDDNGNAIHMTEELHIPQFTF 235
RLT A C L LH FPMD+ +C L SYGY E+I+ W + + T + QF+F
Sbjct: 183 RLTIDAECQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQFSF 242
Query: 236 LGRTITSKEVYFYTGSYIRLILKFQVQREVNSYLVQVYWPTVLTTITSWISFWMNYDSSA 295
+G T++ V +G Y+ + + F + R + + +Q Y P L + SW+SFW+N D+
Sbjct: 243 VGLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVP 302
Query: 296 ARVTIGLTSMLILTTIDSHLRDKLPNISCIKAIDIYILVCLFFVFLSLLEYVYINYLFYS 355
AR ++G+T++L +TT+ + R LP +S + A+D+++ VC FVF +L+EY ++Y +
Sbjct: 303 ARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSN 362
Query: 356 RGPRRQPRRHRR 367
R P + + ++
Sbjct: 363 RKPSKDKDKKKK 374
Score = 40.8 bits (94), Expect = 0.004
Identities = 15/29 (51%), Positives = 22/29 (75%)
Query: 604 VPKVDKWSRFLFPLAFGLFNIVYWVYHMY 632
+ K+D ++R FP AF LFN+VYWV ++Y
Sbjct: 438 IAKMDSYARIFFPTAFCLFNLVYWVSYLY 466
>gi|38788155 gamma-aminobutyric acid A receptor, gamma 2 isoform 1
precursor [Homo sapiens]
Length = 475
Score = 241 bits (616), Expect = 1e-63
Identities = 117/312 (37%), Positives = 184/312 (58%)
Query: 56 EAVVQKILDRVLSRYDVRLRPNFGGAPVPVRISIYVTSIEQISEMNMDYTITMFFHQTWK 115
E V IL+ +L YD +LRP+ G P + +YV SI ++ +NM+YTI +FF QTW
Sbjct: 63 EGDVTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWY 122
Query: 116 DSRLAYYETTLNLTLDYRMHEKLWVPDCYFLNSKDAFVHDVTVENRVFQLHPDGTVRYGI 175
D RL + T L L+ M K+W+PD +F NSK A H +T NR+ ++ DG V Y +
Sbjct: 123 DRRLKFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTL 182
Query: 176 RLTTTAACSLDLHKFPMDKQACNLVVESYGYTVEDIILFWDDNGNAIHMTEELHIPQFTF 235
RLT A C L LH FPMD+ +C L SYGY E+I+ W + + T + QF+F
Sbjct: 183 RLTIDAECQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQFSF 242
Query: 236 LGRTITSKEVYFYTGSYIRLILKFQVQREVNSYLVQVYWPTVLTTITSWISFWMNYDSSA 295
+G T++ V +G Y+ + + F + R + + +Q Y P L + SW+SFW+N D+
Sbjct: 243 VGLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVP 302
Query: 296 ARVTIGLTSMLILTTIDSHLRDKLPNISCIKAIDIYILVCLFFVFLSLLEYVYINYLFYS 355
AR ++G+T++L +TT+ + R LP +S + A+D+++ VC FVF +L+EY ++Y +
Sbjct: 303 ARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSN 362
Query: 356 RGPRRQPRRHRR 367
R P + + ++
Sbjct: 363 RKPSKDKDKKKK 374
Score = 40.8 bits (94), Expect = 0.004
Identities = 15/29 (51%), Positives = 22/29 (75%)
Query: 604 VPKVDKWSRFLFPLAFGLFNIVYWVYHMY 632
+ K+D ++R FP AF LFN+VYWV ++Y
Sbjct: 446 IAKMDSYARIFFPTAFCLFNLVYWVSYLY 474
>gi|157389018 gamma-aminobutyric acid A receptor, alpha 6 precursor
[Homo sapiens]
Length = 453
Score = 236 bits (602), Expect = 5e-62
Identities = 116/295 (39%), Positives = 180/295 (61%), Gaps = 2/295 (0%)
Query: 59 VQKILDRVLSRYDVRLRPNFGGAPVPVRISIYVTSIEQISEMNMDYTITMFFHQTWKDSR 118
V +ILD +L YD RLRP FGGA V+ IYVTS +S++ M+YT+ +FF QTW D R
Sbjct: 32 VSRILDNLLEGYDNRLRPGFGGAVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWTDER 91
Query: 119 LAYYETTLNLTLDYRMHEKLWVPDCYFLNSKDAFVHDVTVENRVFQLHPDGTVRYGIRLT 178
L + T L+L+ M K+W PD +F N K + H++T N++F++ +GT+ Y +RLT
Sbjct: 92 LKFGGPTEILSLNNLMVSKIWTPDTFFRNGKKSIAHNMTTPNKLFRIMQNGTILYTMRLT 151
Query: 179 TTAACSLDLHKFPMDKQACNLVVESYGYTVEDIILFWDDNG-NAIHMTEE-LHIPQFTFL 236
A C + L FPMD AC L SY Y +II W ++ + EE + Q+ +
Sbjct: 152 INADCPMRLVNFPMDGHACPLKFGSYAYPKSEIIYTWKKGPLYSVEVPEESSSLLQYDLI 211
Query: 237 GRTITSKEVYFYTGSYIRLILKFQVQREVNSYLVQVYWPTVLTTITSWISFWMNYDSSAA 296
G+T++S+ + TG Y+ + + F +QR++ +++Q+Y P ++T I S +SFW+N +S A
Sbjct: 212 GQTVSSETIKSNTGEYVIMTVYFHLQRKMGYFMIQIYTPCIMTVILSQVSFWINKESVPA 271
Query: 297 RVTIGLTSMLILTTIDSHLRDKLPNISCIKAIDIYILVCLFFVFLSLLEYVYINY 351
R G+T++L +TT+ R LP +S A+D +I VC FVF +L+E+ +NY
Sbjct: 272 RTVFGITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNY 326
Score = 40.4 bits (93), Expect = 0.005
Identities = 15/26 (57%), Positives = 22/26 (84%)
Query: 606 KVDKWSRFLFPLAFGLFNIVYWVYHM 631
K+D++SR LFP+AF FN+VYWV ++
Sbjct: 416 KIDQYSRILFPVAFAGFNLVYWVVYL 441
>gi|31742490 gamma-aminobutyric acid A receptor, gamma 1 precursor
[Homo sapiens]
Length = 465
Score = 231 bits (588), Expect = 2e-60
Identities = 109/297 (36%), Positives = 176/297 (59%)
Query: 55 NEAVVQKILDRVLSRYDVRLRPNFGGAPVPVRISIYVTSIEQISEMNMDYTITMFFHQTW 114
+E + +IL+ +L YD +LRP+ G P + +YV SI + +NM+YTI + F QTW
Sbjct: 60 HEGDITQILNSLLQGYDNKLRPDIGVRPTVIETDVYVNSIGPVDPINMEYTIDIIFAQTW 119
Query: 115 KDSRLAYYETTLNLTLDYRMHEKLWVPDCYFLNSKDAFVHDVTVENRVFQLHPDGTVRYG 174
DSRL + T L L+ M K+W+PD +F NS+ + H +T NR+ ++ DG V Y
Sbjct: 120 FDSRLKFNSTMKVLMLNSNMVGKIWIPDTFFRNSRKSDAHWITTPNRLLRIWNDGRVLYT 179
Query: 175 IRLTTTAACSLDLHKFPMDKQACNLVVESYGYTVEDIILFWDDNGNAIHMTEELHIPQFT 234
+RLT A C L LH FPMD+ +C L SYGY +I W + + + QF
Sbjct: 180 LRLTINAECYLQLHNFPMDEHSCPLEFSSYGYPKNEIEYKWKKPSVEVADPKYWRLYQFA 239
Query: 235 FLGRTITSKEVYFYTGSYIRLILKFQVQREVNSYLVQVYWPTVLTTITSWISFWMNYDSS 294
F+G +++ + +G Y+ + + F + R + + +Q Y P +LT + SW+SFW+N D+
Sbjct: 240 FVGLRNSTEITHTISGDYVIMTIFFDLSRRMGYFTIQTYIPCILTVVLSWVSFWINKDAV 299
Query: 295 AARVTIGLTSMLILTTIDSHLRDKLPNISCIKAIDIYILVCLFFVFLSLLEYVYINY 351
AR ++G+T++L +TT+ + R LP +S + A+D+++ VC FVF +L+EY ++Y
Sbjct: 300 PARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFAALMEYGTLHY 356
Score = 43.5 bits (101), Expect = 6e-04
Identities = 16/29 (55%), Positives = 22/29 (75%)
Query: 604 VPKVDKWSRFLFPLAFGLFNIVYWVYHMY 632
+ K+D +SR FP AF LFN+VYWV ++Y
Sbjct: 436 IAKIDSYSRIFFPTAFALFNLVYWVGYLY 464
>gi|52426761 gamma-aminobutyric acid (GABA) A receptor, epsilon
precursor [Homo sapiens]
Length = 506
Score = 230 bits (586), Expect = 3e-60
Identities = 132/378 (34%), Positives = 202/378 (53%), Gaps = 27/378 (7%)
Query: 61 KILDRVLSRYDVRLRPNFGGAPVPVRISIYVTSIEQISEMNMDYTITMFFHQTWKDSRLA 120
+IL+ +LS YD +LRP G P V + I V S+ +S ++M+YTI + F QTW D RL
Sbjct: 73 RILNTILSNYDHKLRPGIGEKPTVVTVEISVNSLGPLSILDMEYTIDIIFSQTWYDERLC 132
Query: 121 YYETTLNLTLDYRMHEKLWVPDCYFLNSKDAFVHDVTVENRVFQLHPDGTVRYGIRLTTT 180
Y +T +L L+ + +LW+PD +F NSK H++T+ N++ +++ DG V Y IR+T
Sbjct: 133 YNDTFESLVLNGNVVSQLWIPDTFFRNSKRTHEHEITMPNQMVRIYKDGKVLYTIRMTID 192
Query: 181 AACSLDLHKFPMDKQACNLVVESYGYTVEDIILFWDDNGNAIHMTEELHIPQFTFLGRTI 240
A CSL + +FPMD +C L S+ Y ++I W++ I+ + QF F G +
Sbjct: 193 AGCSLHMLRFPMDSHSCPLSFSSFSYPENEMIYKWENFKLEINEKNSWKLFQFDFTGVSN 252
Query: 241 TSKEVYFYTGSYIRLILKFQVQREVNSYLVQVYWPTVLTTITSWISFWMNYDSSAARVTI 300
++ + G ++ + + F V R Q Y P+ +TT+ SW+SFW+ +S+ AR ++
Sbjct: 253 KTEIITTPVGDFMVMTIFFNVSRRFGYVAFQNYVPSSVTTMLSWVSFWIKTESAPARTSL 312
Query: 301 GLTSMLILTTIDSHLRDKLPNISCIKAIDIYILVCLFFVFLSLLEYVYINYLFYS----- 355
G+TS+L +TT+ + R P +S I A+D YI +C F F +LLE+ +N+L Y+
Sbjct: 313 GITSVLTMTTLGTFSRKNFPRVSYITALDFYIAICFVFCFCALLEFAVLNFLIYNQTKAH 372
Query: 356 -----RGPRRQPRRHRRPR---RVIARYRYQ----QVVVGNVQDGLINVEDGVSSLPITP 403
R PR R H R R R AR + Q+V DG P
Sbjct: 373 ASPKLRHPRINSRAHARTRARSRACARQHQEAFVCQIVTTEGSDG--------EERPSCS 424
Query: 404 AQAPLA--SPESLGSLTS 419
AQ P + SPE SL S
Sbjct: 425 AQQPPSPGSPEGPRSLCS 442
Score = 35.8 bits (81), Expect = 0.12
Identities = 29/110 (26%), Positives = 47/110 (42%), Gaps = 38/110 (34%)
Query: 547 KEQFKCDTNSTWGLNDDELMAHGQEKDSSSESEDSCPPSPG--------------CSFTE 592
+E F C +T G + G+E+ S S + PPSPG C + +
Sbjct: 402 QEAFVCQIVTTEG-------SDGEERPSCSAQQ---PPSPGSPEGPRSLCSKLACCEWCK 451
Query: 593 GFS-FDLFNPD-------------YVPKVDKWSRFLFPLAFGLFNIVYWV 628
F + PD +V ++D +SR +FP+ F FN++YW+
Sbjct: 452 RFKKYFCMVPDCEGSTWQQGRLCIHVYRLDNYSRVVFPVTFFFFNVLYWL 501
>gi|4504023 glycine receptor, beta [Homo sapiens]
Length = 497
Score = 228 bits (582), Expect = 1e-59
Identities = 126/330 (38%), Positives = 190/330 (57%), Gaps = 14/330 (4%)
Query: 62 ILDRVLSRYDVRLRPNFGGAPVPVRISIYVTSIEQISEMNMDYTITMFFHQTWKDSRLAY 121
IL+R+L YD R+RPNF G PV V ++I++ S I E MDY + +F Q W D RL
Sbjct: 59 ILNRLLVSYDPRIRPNFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLKL 118
Query: 122 ---YETTLNLTLDYRMHEKLWVPDCYFLNSKDAFVHDVTVENRVFQLHPDGTVRYGIRLT 178
+ + LT+D M++ LW PD +F N K A HDVT EN + + DG V +RL+
Sbjct: 119 PSDFRGSDALTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMRLS 178
Query: 179 TTAACSLDLHKFPMDKQACNLVVESYGYTVEDIILFWDDNGNAIHMTEELHIPQFTFLGR 238
T +C LDL FPMD Q C + +ES+GYT +D+ W +G+ + + E++ +PQF
Sbjct: 179 ITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQ-SGDPVQL-EKIALPQFDIKKE 236
Query: 239 TI---TSKEVYFYTGSYIRLILKFQVQREVNSYLVQVYWPTVLTTITSWISFWMNYDSSA 295
I + Y TG Y + + F ++R+V Y++ VY PT+L + SW+SFW+N D+SA
Sbjct: 237 DIEYGNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASA 296
Query: 296 ARVTIGLTSMLILTTIDSHLRDKLPNISCIKAIDIYILVCLFFVFLSLLEYVYINYLFYS 355
ARV +G+ S+L L + + L +LP +S +KA+D++++ CL F F SL+EY + +
Sbjct: 297 ARVPLGIFSVLSLASECTTLAAELPKVSYVKALDVWLIACLLFGFASLVEYAVVQVML-- 354
Query: 356 RGPRRQPRRHRRPRRVIARYRYQQVVVGNV 385
P+R + IA+ GNV
Sbjct: 355 ----NNPKRVEAEKARIAKAEQADGKGGNV 380
Score = 33.1 bits (74), Expect = 0.80
Identities = 11/31 (35%), Positives = 19/31 (61%)
Query: 601 PDYVPKVDKWSRFLFPLAFGLFNIVYWVYHM 631
P ++D ++R LFP F FN++YW ++
Sbjct: 467 PTAAKRIDLYARALFPFCFLFFNVIYWSIYL 497
>gi|189083734 gamma-aminobutyric acid (GABA) A receptor, alpha 1
precursor [Homo sapiens]
Length = 456
Score = 228 bits (581), Expect = 1e-59
Identities = 115/305 (37%), Positives = 180/305 (59%), Gaps = 3/305 (0%)
Query: 55 NEAVVQKILDRVLSRYDVRLRPNFGGAPVPVRISIYVTSIEQISEMNMDYTITMFFHQTW 114
N V +ILDR+L YD RLRP G V+ I+VTS +S+ +M+YTI +FF Q+W
Sbjct: 38 NTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSW 97
Query: 115 KDSRLAYYETTLNLTLDYRMHEKLWVPDCYFLNSKDAFVHDVTVENRVFQLHPDGTVRYG 174
KD RL + L L+ M K+W PD +F N K + H++T+ N++ ++ DGT+ Y
Sbjct: 98 KDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYT 157
Query: 175 IRLTTTAACSLDLHKFPMDKQACNLVVESYGYTVEDIILFWD-DNGNAIHMTEE-LHIPQ 232
+RLT A C + L FPMD AC L SY YT +++ W + ++ + E+ + Q
Sbjct: 158 MRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQ 217
Query: 233 FTFLGRTITSKEVYFYTGSYIRLILKFQVQREVNSYLVQVYWPTVLTTITSWISFWMNYD 292
+ LG+T+ S V TG Y+ + F ++R++ +++Q Y P ++T I S +SFW+N +
Sbjct: 218 YDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRE 277
Query: 293 SSAARVTIGLTSMLILTTIDSHLRDKLPNISCIKAIDIYILVCLFFVFLSLLEYVYINYL 352
S AR G+T++L +TT+ R+ LP ++ A+D +I VC FVF +L+E+ +NY
Sbjct: 278 SVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNY- 336
Query: 353 FYSRG 357
F RG
Sbjct: 337 FTKRG 341
Score = 40.8 bits (94), Expect = 0.004
Identities = 19/49 (38%), Positives = 26/49 (53%), Gaps = 11/49 (22%)
Query: 583 PPSPGCSFTEGFSFDLFNPDYVPKVDKWSRFLFPLAFGLFNIVYWVYHM 631
PP P +F V K+D+ SR FPL FG+FN+VYW ++
Sbjct: 406 PPEPKKTFNS-----------VSKIDRLSRIAFPLLFGIFNLVYWATYL 443
>gi|189083732 gamma-aminobutyric acid (GABA) A receptor, alpha 1
precursor [Homo sapiens]
Length = 456
Score = 228 bits (581), Expect = 1e-59
Identities = 115/305 (37%), Positives = 180/305 (59%), Gaps = 3/305 (0%)
Query: 55 NEAVVQKILDRVLSRYDVRLRPNFGGAPVPVRISIYVTSIEQISEMNMDYTITMFFHQTW 114
N V +ILDR+L YD RLRP G V+ I+VTS +S+ +M+YTI +FF Q+W
Sbjct: 38 NTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSW 97
Query: 115 KDSRLAYYETTLNLTLDYRMHEKLWVPDCYFLNSKDAFVHDVTVENRVFQLHPDGTVRYG 174
KD RL + L L+ M K+W PD +F N K + H++T+ N++ ++ DGT+ Y
Sbjct: 98 KDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYT 157
Query: 175 IRLTTTAACSLDLHKFPMDKQACNLVVESYGYTVEDIILFWD-DNGNAIHMTEE-LHIPQ 232
+RLT A C + L FPMD AC L SY YT +++ W + ++ + E+ + Q
Sbjct: 158 MRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQ 217
Query: 233 FTFLGRTITSKEVYFYTGSYIRLILKFQVQREVNSYLVQVYWPTVLTTITSWISFWMNYD 292
+ LG+T+ S V TG Y+ + F ++R++ +++Q Y P ++T I S +SFW+N +
Sbjct: 218 YDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRE 277
Query: 293 SSAARVTIGLTSMLILTTIDSHLRDKLPNISCIKAIDIYILVCLFFVFLSLLEYVYINYL 352
S AR G+T++L +TT+ R+ LP ++ A+D +I VC FVF +L+E+ +NY
Sbjct: 278 SVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNY- 336
Query: 353 FYSRG 357
F RG
Sbjct: 337 FTKRG 341
Score = 40.8 bits (94), Expect = 0.004
Identities = 19/49 (38%), Positives = 26/49 (53%), Gaps = 11/49 (22%)
Query: 583 PPSPGCSFTEGFSFDLFNPDYVPKVDKWSRFLFPLAFGLFNIVYWVYHM 631
PP P +F V K+D+ SR FPL FG+FN+VYW ++
Sbjct: 406 PPEPKKTFNS-----------VSKIDRLSRIAFPLLFGIFNLVYWATYL 443
>gi|189083730 gamma-aminobutyric acid (GABA) A receptor, alpha 1
precursor [Homo sapiens]
Length = 456
Score = 228 bits (581), Expect = 1e-59
Identities = 115/305 (37%), Positives = 180/305 (59%), Gaps = 3/305 (0%)
Query: 55 NEAVVQKILDRVLSRYDVRLRPNFGGAPVPVRISIYVTSIEQISEMNMDYTITMFFHQTW 114
N V +ILDR+L YD RLRP G V+ I+VTS +S+ +M+YTI +FF Q+W
Sbjct: 38 NTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSW 97
Query: 115 KDSRLAYYETTLNLTLDYRMHEKLWVPDCYFLNSKDAFVHDVTVENRVFQLHPDGTVRYG 174
KD RL + L L+ M K+W PD +F N K + H++T+ N++ ++ DGT+ Y
Sbjct: 98 KDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYT 157
Query: 175 IRLTTTAACSLDLHKFPMDKQACNLVVESYGYTVEDIILFWD-DNGNAIHMTEE-LHIPQ 232
+RLT A C + L FPMD AC L SY YT +++ W + ++ + E+ + Q
Sbjct: 158 MRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQ 217
Query: 233 FTFLGRTITSKEVYFYTGSYIRLILKFQVQREVNSYLVQVYWPTVLTTITSWISFWMNYD 292
+ LG+T+ S V TG Y+ + F ++R++ +++Q Y P ++T I S +SFW+N +
Sbjct: 218 YDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRE 277
Query: 293 SSAARVTIGLTSMLILTTIDSHLRDKLPNISCIKAIDIYILVCLFFVFLSLLEYVYINYL 352
S AR G+T++L +TT+ R+ LP ++ A+D +I VC FVF +L+E+ +NY
Sbjct: 278 SVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNY- 336
Query: 353 FYSRG 357
F RG
Sbjct: 337 FTKRG 341
Score = 40.8 bits (94), Expect = 0.004
Identities = 19/49 (38%), Positives = 26/49 (53%), Gaps = 11/49 (22%)
Query: 583 PPSPGCSFTEGFSFDLFNPDYVPKVDKWSRFLFPLAFGLFNIVYWVYHM 631
PP P +F V K+D+ SR FPL FG+FN+VYW ++
Sbjct: 406 PPEPKKTFNS-----------VSKIDRLSRIAFPLLFGIFNLVYWATYL 443
>gi|189083728 gamma-aminobutyric acid (GABA) A receptor, alpha 1
precursor [Homo sapiens]
Length = 456
Score = 228 bits (581), Expect = 1e-59
Identities = 115/305 (37%), Positives = 180/305 (59%), Gaps = 3/305 (0%)
Query: 55 NEAVVQKILDRVLSRYDVRLRPNFGGAPVPVRISIYVTSIEQISEMNMDYTITMFFHQTW 114
N V +ILDR+L YD RLRP G V+ I+VTS +S+ +M+YTI +FF Q+W
Sbjct: 38 NTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSW 97
Query: 115 KDSRLAYYETTLNLTLDYRMHEKLWVPDCYFLNSKDAFVHDVTVENRVFQLHPDGTVRYG 174
KD RL + L L+ M K+W PD +F N K + H++T+ N++ ++ DGT+ Y
Sbjct: 98 KDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYT 157
Query: 175 IRLTTTAACSLDLHKFPMDKQACNLVVESYGYTVEDIILFWD-DNGNAIHMTEE-LHIPQ 232
+RLT A C + L FPMD AC L SY YT +++ W + ++ + E+ + Q
Sbjct: 158 MRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQ 217
Query: 233 FTFLGRTITSKEVYFYTGSYIRLILKFQVQREVNSYLVQVYWPTVLTTITSWISFWMNYD 292
+ LG+T+ S V TG Y+ + F ++R++ +++Q Y P ++T I S +SFW+N +
Sbjct: 218 YDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRE 277
Query: 293 SSAARVTIGLTSMLILTTIDSHLRDKLPNISCIKAIDIYILVCLFFVFLSLLEYVYINYL 352
S AR G+T++L +TT+ R+ LP ++ A+D +I VC FVF +L+E+ +NY
Sbjct: 278 SVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNY- 336
Query: 353 FYSRG 357
F RG
Sbjct: 337 FTKRG 341
Score = 40.8 bits (94), Expect = 0.004
Identities = 19/49 (38%), Positives = 26/49 (53%), Gaps = 11/49 (22%)
Query: 583 PPSPGCSFTEGFSFDLFNPDYVPKVDKWSRFLFPLAFGLFNIVYWVYHM 631
PP P +F V K+D+ SR FPL FG+FN+VYW ++
Sbjct: 406 PPEPKKTFNS-----------VSKIDRLSRIAFPLLFGIFNLVYWATYL 443
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.136 0.420
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,237,397
Number of Sequences: 37866
Number of extensions: 1088643
Number of successful extensions: 4016
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 56
Number of HSP's successfully gapped in prelim test: 48
Number of HSP's that attempted gapping in prelim test: 3809
Number of HSP's gapped (non-prelim): 197
length of query: 632
length of database: 18,247,518
effective HSP length: 108
effective length of query: 524
effective length of database: 14,157,990
effective search space: 7418786760
effective search space used: 7418786760
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.