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Search of human proteins with 8923909
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens]
(1371 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens] 2735 0.0
gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens] 2411 0.0
gi|16904383 leucine rich repeat containing 7 [Homo sapiens] 698 0.0
gi|45827729 scribble isoform b [Homo sapiens] 389 e-107
gi|45827731 scribble isoform a [Homo sapiens] 389 e-107
gi|95113664 leucine rich repeat containing 1 [Homo sapiens] 375 e-103
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens] 190 9e-48
gi|122937315 leucine-rich repeats and IQ motif containing 4 [Hom... 173 9e-43
gi|238908508 leucine-rich repeat and death domain-containing pro... 170 8e-42
gi|110825984 malignant fibrous histiocytoma amplified sequence 1... 150 6e-36
gi|21361633 leucine rich repeat containing 40 [Homo sapiens] 149 2e-35
gi|4503743 flightless I homolog [Homo sapiens] 139 2e-32
gi|65301141 PH domain and leucine rich repeat protein phosphatas... 124 8e-28
gi|197333692 leucine rich repeat containing 8 family, member B [... 123 1e-27
gi|21245134 leucine rich repeat containing 8 family, member B [H... 123 1e-27
gi|40217803 leucine rich repeat containing 8 family, member E [H... 120 7e-27
gi|62241040 leucine rich repeat containing 8 family, member A [H... 115 4e-25
gi|187829877 leucine rich repeat containing 8 family, member A [... 115 4e-25
gi|187829871 leucine rich repeat containing 8 family, member A [... 115 4e-25
gi|21389431 leucine rich repeat containing 39 [Homo sapiens] 114 8e-25
gi|19923729 leucine rich repeat containing 8 family, member C [H... 112 2e-24
gi|61742786 leucine rich repeat and death domain containing prot... 112 3e-24
gi|61742784 leucine rich repeat and death domain containing prot... 112 3e-24
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 111 4e-24
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 111 4e-24
gi|197333706 leucine rich repeat containing 8 family, member D [... 110 7e-24
gi|34222199 leucine rich repeat containing 8 family, member D [H... 110 7e-24
gi|37221175 PH domain and leucine rich repeat protein phosphatas... 105 4e-22
gi|4504379 leucine-rich repeat-containing G protein-coupled rece... 105 4e-22
gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens] 105 4e-22
>gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens]
Length = 1371
Score = 2735 bits (7089), Expect = 0.0
Identities = 1371/1371 (100%), Positives = 1371/1371 (100%)
Query: 1 MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEE 60
MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEE
Sbjct: 1 MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEE 60
Query: 61 LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIV 120
LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIV
Sbjct: 61 LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIV 120
Query: 121 EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM 180
EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM
Sbjct: 121 EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM 180
Query: 181 NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN 240
NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN
Sbjct: 181 NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN 240
Query: 241 NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLIS 300
NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLIS
Sbjct: 241 NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLIS 300
Query: 301 VEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL 360
VEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL
Sbjct: 301 VEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL 360
Query: 361 PEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKM 420
PEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKM
Sbjct: 361 PEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKM 420
Query: 421 VLTNYMFPQQPRTEDVMFISDNESFNPSLWEEQRKQRAQVAFECDEDKDEREAPPREGNL 480
VLTNYMFPQQPRTEDVMFISDNESFNPSLWEEQRKQRAQVAFECDEDKDEREAPPREGNL
Sbjct: 421 VLTNYMFPQQPRTEDVMFISDNESFNPSLWEEQRKQRAQVAFECDEDKDEREAPPREGNL 480
Query: 481 KRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTT 540
KRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTT
Sbjct: 481 KRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTT 540
Query: 541 TVKSKVDEREKYMIGNSVQKISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESEE 600
TVKSKVDEREKYMIGNSVQKISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESEE
Sbjct: 541 TVKSKVDEREKYMIGNSVQKISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESEE 600
Query: 601 LSSDEEMKMAEMRPPLIETSINQPKVVALSNNKKDDTKETDSLSDEVTHNSNQNNSNCSS 660
LSSDEEMKMAEMRPPLIETSINQPKVVALSNNKKDDTKETDSLSDEVTHNSNQNNSNCSS
Sbjct: 601 LSSDEEMKMAEMRPPLIETSINQPKVVALSNNKKDDTKETDSLSDEVTHNSNQNNSNCSS 660
Query: 661 PSRMSDSVSLNTDSSQDTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTEEKF 720
PSRMSDSVSLNTDSSQDTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTEEKF
Sbjct: 661 PSRMSDSVSLNTDSSQDTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTEEKF 720
Query: 721 KAHDKKDFNLPEYDLNVEERLVLIEKSVDSTATADDTHKLDHINMNLNKLITNDTFQPEI 780
KAHDKKDFNLPEYDLNVEERLVLIEKSVDSTATADDTHKLDHINMNLNKLITNDTFQPEI
Sbjct: 721 KAHDKKDFNLPEYDLNVEERLVLIEKSVDSTATADDTHKLDHINMNLNKLITNDTFQPEI 780
Query: 781 MERSKTQDIVLGTSFLSINSKEETEHLENGNKYPNLESVNKVNGHSEETSQSPNRTEPHD 840
MERSKTQDIVLGTSFLSINSKEETEHLENGNKYPNLESVNKVNGHSEETSQSPNRTEPHD
Sbjct: 781 MERSKTQDIVLGTSFLSINSKEETEHLENGNKYPNLESVNKVNGHSEETSQSPNRTEPHD 840
Query: 841 SDCSVDLGISKSTEDLSPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNGPQQPSTTVK 900
SDCSVDLGISKSTEDLSPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNGPQQPSTTVK
Sbjct: 841 SDCSVDLGISKSTEDLSPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNGPQQPSTTVK 900
Query: 901 ITSAVDGKNIVRSKSATLLYDQPLQVFTGSSSSSDLISGTKAIFKFDSNHNPEEPNIIRG 960
ITSAVDGKNIVRSKSATLLYDQPLQVFTGSSSSSDLISGTKAIFKFDSNHNPEEPNIIRG
Sbjct: 901 ITSAVDGKNIVRSKSATLLYDQPLQVFTGSSSSSDLISGTKAIFKFDSNHNPEEPNIIRG 960
Query: 961 PTSGPQSAPQIYGPPQYNIQYSSSAAVKDTLWHSKQNPQIDHASFPPQLLPRSESTENQS 1020
PTSGPQSAPQIYGPPQYNIQYSSSAAVKDTLWHSKQNPQIDHASFPPQLLPRSESTENQS
Sbjct: 961 PTSGPQSAPQIYGPPQYNIQYSSSAAVKDTLWHSKQNPQIDHASFPPQLLPRSESTENQS 1020
Query: 1021 YAKHSANMNFSNHNNVRANTAYHLHQRLGPARHGEMWAISPNDRLIPAVTRSTIQRQSSV 1080
YAKHSANMNFSNHNNVRANTAYHLHQRLGPARHGEMWAISPNDRLIPAVTRSTIQRQSSV
Sbjct: 1021 YAKHSANMNFSNHNNVRANTAYHLHQRLGPARHGEMWAISPNDRLIPAVTRSTIQRQSSV 1080
Query: 1081 SSTASVNLGDPGSTRRAQIPEGDYLSYREFHSAGRTPPMMPGSQRPLSARTYSIDGPNAS 1140
SSTASVNLGDPGSTRRAQIPEGDYLSYREFHSAGRTPPMMPGSQRPLSARTYSIDGPNAS
Sbjct: 1081 SSTASVNLGDPGSTRRAQIPEGDYLSYREFHSAGRTPPMMPGSQRPLSARTYSIDGPNAS 1140
Query: 1141 RPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNARVGSEHSLLDPPGKSKVPRDWREQV 1200
RPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNARVGSEHSLLDPPGKSKVPRDWREQV
Sbjct: 1141 RPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNARVGSEHSLLDPPGKSKVPRDWREQV 1200
Query: 1201 LRHIEAKKLEKMPLSNGQMGQPLRPQANYSQIHHPPQASVARHPSREQLIDYLMLKVAHQ 1260
LRHIEAKKLEKMPLSNGQMGQPLRPQANYSQIHHPPQASVARHPSREQLIDYLMLKVAHQ
Sbjct: 1201 LRHIEAKKLEKMPLSNGQMGQPLRPQANYSQIHHPPQASVARHPSREQLIDYLMLKVAHQ 1260
Query: 1261 PPYTQPHCSPRQGHELAKQEIRVRVEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQP 1320
PPYTQPHCSPRQGHELAKQEIRVRVEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQP
Sbjct: 1261 PPYTQPHCSPRQGHELAKQEIRVRVEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQP 1320
Query: 1321 EGPASKLLQPGDKIIQANGYSFINIEHGQAVSLLKTFQNTVELIIVREVSS 1371
EGPASKLLQPGDKIIQANGYSFINIEHGQAVSLLKTFQNTVELIIVREVSS
Sbjct: 1321 EGPASKLLQPGDKIIQANGYSFINIEHGQAVSLLKTFQNTVELIIVREVSS 1371
>gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens]
Length = 1302
Score = 2411 bits (6248), Expect = 0.0
Identities = 1211/1212 (99%), Positives = 1212/1212 (100%)
Query: 1 MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEE 60
MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEE
Sbjct: 1 MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEE 60
Query: 61 LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIV 120
LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIV
Sbjct: 61 LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIV 120
Query: 121 EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM 180
EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM
Sbjct: 121 EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM 180
Query: 181 NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN 240
NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN
Sbjct: 181 NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN 240
Query: 241 NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLIS 300
NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLIS
Sbjct: 241 NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLIS 300
Query: 301 VEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL 360
VEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL
Sbjct: 301 VEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL 360
Query: 361 PEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKM 420
PEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKM
Sbjct: 361 PEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKM 420
Query: 421 VLTNYMFPQQPRTEDVMFISDNESFNPSLWEEQRKQRAQVAFECDEDKDEREAPPREGNL 480
VLTNYMFPQQPRTEDVMFISDNESFNPSLWEEQRKQRAQVAFECDEDKDEREAPPREGNL
Sbjct: 421 VLTNYMFPQQPRTEDVMFISDNESFNPSLWEEQRKQRAQVAFECDEDKDEREAPPREGNL 480
Query: 481 KRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTT 540
KRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTT
Sbjct: 481 KRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTT 540
Query: 541 TVKSKVDEREKYMIGNSVQKISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESEE 600
TVKSKVDEREKYMIGNSVQKISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESEE
Sbjct: 541 TVKSKVDEREKYMIGNSVQKISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESEE 600
Query: 601 LSSDEEMKMAEMRPPLIETSINQPKVVALSNNKKDDTKETDSLSDEVTHNSNQNNSNCSS 660
LSSDEEMKMAEMRPPLIETSINQPKVVALSNNKKDDTKETDSLSDEVTHNSNQNNSNCSS
Sbjct: 601 LSSDEEMKMAEMRPPLIETSINQPKVVALSNNKKDDTKETDSLSDEVTHNSNQNNSNCSS 660
Query: 661 PSRMSDSVSLNTDSSQDTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTEEKF 720
PSRMSDSVSLNTDSSQDTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTEEKF
Sbjct: 661 PSRMSDSVSLNTDSSQDTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTEEKF 720
Query: 721 KAHDKKDFNLPEYDLNVEERLVLIEKSVDSTATADDTHKLDHINMNLNKLITNDTFQPEI 780
KAHDKKDFNLPEYDLNVEERLVLIEKSVDSTATADDTHKLDHINMNLNKLITNDTFQPEI
Sbjct: 721 KAHDKKDFNLPEYDLNVEERLVLIEKSVDSTATADDTHKLDHINMNLNKLITNDTFQPEI 780
Query: 781 MERSKTQDIVLGTSFLSINSKEETEHLENGNKYPNLESVNKVNGHSEETSQSPNRTEPHD 840
MERSKTQDIVLGTSFLSINSKEETEHLENGNKYPNLESVNKVNGHSEETSQSPNRTEPHD
Sbjct: 781 MERSKTQDIVLGTSFLSINSKEETEHLENGNKYPNLESVNKVNGHSEETSQSPNRTEPHD 840
Query: 841 SDCSVDLGISKSTEDLSPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNGPQQPSTTVK 900
SDCSVDLGISKSTEDLSPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNGPQQPSTTVK
Sbjct: 841 SDCSVDLGISKSTEDLSPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNGPQQPSTTVK 900
Query: 901 ITSAVDGKNIVRSKSATLLYDQPLQVFTGSSSSSDLISGTKAIFKFDSNHNPEEPNIIRG 960
ITSAVDGKNIVRSKSATLLYDQPLQVFTGSSSSSDLISGTKAIFKFDSNHNPEEPNIIRG
Sbjct: 901 ITSAVDGKNIVRSKSATLLYDQPLQVFTGSSSSSDLISGTKAIFKFDSNHNPEEPNIIRG 960
Query: 961 PTSGPQSAPQIYGPPQYNIQYSSSAAVKDTLWHSKQNPQIDHASFPPQLLPRSESTENQS 1020
PTSGPQSAPQIYGPPQYNIQYSSSAAVKDTLWHSKQNPQIDHASFPPQLLPRSESTENQS
Sbjct: 961 PTSGPQSAPQIYGPPQYNIQYSSSAAVKDTLWHSKQNPQIDHASFPPQLLPRSESTENQS 1020
Query: 1021 YAKHSANMNFSNHNNVRANTAYHLHQRLGPARHGEMWAISPNDRLIPAVTRSTIQRQSSV 1080
YAKHSANMNFSNHNNVRANTAYHLHQRLGPARHGEMWAISPNDRLIPAVTRSTIQRQSSV
Sbjct: 1021 YAKHSANMNFSNHNNVRANTAYHLHQRLGPARHGEMWAISPNDRLIPAVTRSTIQRQSSV 1080
Query: 1081 SSTASVNLGDPGSTRRAQIPEGDYLSYREFHSAGRTPPMMPGSQRPLSARTYSIDGPNAS 1140
SSTASVNLGDPGSTRRAQIPEGDYLSYREFHSAGRTPPMMPGSQRPLSARTYSIDGPNAS
Sbjct: 1081 SSTASVNLGDPGSTRRAQIPEGDYLSYREFHSAGRTPPMMPGSQRPLSARTYSIDGPNAS 1140
Query: 1141 RPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNARVGSEHSLLDPPGKSKVPRDWREQV 1200
RPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNARVGSEHSLLDPPGKSKVPRDWREQV
Sbjct: 1141 RPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNARVGSEHSLLDPPGKSKVPRDWREQV 1200
Query: 1201 LRHIEAKKLEKM 1212
LRHIEAKKLEK+
Sbjct: 1201 LRHIEAKKLEKI 1212
>gi|16904383 leucine rich repeat containing 7 [Homo sapiens]
Length = 1537
Score = 698 bits (1801), Expect = 0.0
Identities = 385/708 (54%), Positives = 481/708 (67%), Gaps = 42/708 (5%)
Query: 1 MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEE 60
MTTKR + RLVPCRC RGEEE ++ LDYSHCSL+QVPKE+F FE+TLEELYLDANQIEE
Sbjct: 1 MTTKRKIIGRLVPCRCFRGEEEIISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEE 60
Query: 61 LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIV 120
LPKQLFNCQ+L KLS+PDNDL+ LP +IA+L+NL+ELD+SKNG+QEFPENIK CK LTI+
Sbjct: 61 LPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTII 120
Query: 121 EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM 180
EASVNPISKLPDGF+QLLNLTQLYLNDAFLEFLPANFGRL KL+ILELREN LK LPK+M
Sbjct: 121 EASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSM 180
Query: 181 NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN 240
++L QLERLDLG+NEF E+PEVL+Q+ L+E WMD N L +PG IG LK L YLD+SKN
Sbjct: 181 HKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKN 240
Query: 241 NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLIS 300
IE V+ IS CE L+DLLLSSN LQQLP++IG LK +TTLK+D+NQL LP++IG L
Sbjct: 241 RIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSL 300
Query: 301 VEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL 360
+EE DCS NE+E+LPS+IG L +LRT A D N+L +LP EIGS KN+TV+ L SNKLE L
Sbjct: 301 LEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFL 360
Query: 361 PEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKM 420
PEE+G MQKL+V+NLSDNRLKNLPFSFTKL++L A+WLSDNQSK LIPLQ E ET++
Sbjct: 361 PEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKALIPLQTEAHPETKQR 420
Query: 421 VLTNYMFPQQPRTEDVMFISDNESFNPSLWEEQRKQRAQVAFECDEDKDEREAPPREGNL 480
VLTNYMFPQQPR D F SD++SFNP+LWEEQR+QR VAFE ++ K++ E G +
Sbjct: 421 VLTNYMFPQQPR-GDEDFQSDSDSFNPTLWEEQRQQRMTVAFEFEDKKEDDE---NAGKV 476
Query: 481 KRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLK------PHED----------- 523
K P E T+Q RL + + D + P D
Sbjct: 477 KDLSCQAPWERGQRGITLQPA--RLSGDCCTPWARCDQQIQDMPVPQNDPQLAWGCISGL 534
Query: 524 QQDINKDVGVKTSESTTTVKS---------------KVDEREKYMIGNSVQKISEPEAEI 568
QQ+ + + + +TT+ S E K M+ + + +P +
Sbjct: 535 QQERSMCTPLPVAAQSTTLPSLSGRQVEINLKRYPTPYPEDLKNMVKSVQNLVGKPSHGV 594
Query: 569 SPGSLPVTAN----MKASENLKHIVNHDDVFEESEELSSDEEMKMAEMRPPLIETSINQP 624
+ TAN +K K V ++ E + EM++ E+ P L ET + P
Sbjct: 595 RVENSNPTANTEQTVKEKYEHKWPVAPKEITVEDSFVHPANEMRIGELHPSLAETPLYPP 654
Query: 625 KVVALSNNKKDDTKETDSLSDEVTHNSNQNNSNCSSPSRMSDSVSLNT 672
K+V L +KK+ T E++ +NS + + + S S NT
Sbjct: 655 KLVLLGKDKKESTDESEVDKTHCLNNSVSSGTYSDYSPSQASSGSSNT 702
Score = 139 bits (349), Expect = 2e-32
Identities = 63/92 (68%), Positives = 82/92 (89%)
Query: 1279 QEIRVRVEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKLLQPGDKIIQAN 1338
++ VR+EK+P LGFSISGG+ G+GNPF+P D GIFVTRVQP+GPAS LLQPGDKI+QAN
Sbjct: 1445 EQFCVRIEKNPGLGFSISGGISGQGNPFKPSDKGIFVTRVQPDGPASNLLQPGDKILQAN 1504
Query: 1339 GYSFINIEHGQAVSLLKTFQNTVELIIVREVS 1370
G+SF+++EH +AV LLK+FQNTV+L+I RE++
Sbjct: 1505 GHSFVHMEHEKAVLLLKSFQNTVDLVIQRELT 1536
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 389 bits (998), Expect = e-107
Identities = 225/553 (40%), Positives = 333/553 (60%), Gaps = 15/553 (2%)
Query: 24 VTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTT 83
V ++D HCSL+ VP+EI+ + ++LEEL LDANQ+ ELPK F +L KL L DN++
Sbjct: 14 VESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQR 73
Query: 84 LPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQL 143
LP +AN + L ELDVS+N I E PE+IK CK L I + S NP+S+LPDGF+QL +L L
Sbjct: 74 LPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHL 133
Query: 144 YLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVL 203
LND L+ LP + G L L LELREN LK LP +++ L +LE+LDLG N+ +P+ L
Sbjct: 134 ALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTL 193
Query: 204 EQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSN 263
L L+E W+D N+L+ +P +G+L++L LDVS+N +E + + L DLLLS N
Sbjct: 194 GALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQN 253
Query: 264 SLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTN 323
L++LP+ IG LK ++ LK+D+N+L + ++IG ++ EL + N + ALP S+G+LT
Sbjct: 254 LLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTK 313
Query: 324 LRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNL 383
L D N+L+ LPPEIG ++VL L N+L LP E+ +L V++++ NRL++L
Sbjct: 314 LTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSL 373
Query: 384 PFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQP--RTEDVMFISD 441
PF+ T L L A+WL++NQ++P++ Q E D+ T + VLT Y+ PQQP ED +
Sbjct: 374 PFALTHL-NLKALWLAENQAQPMLRFQTEDDARTGEKVLTCYLLPQQPPLSLED----AG 428
Query: 442 NESFNPSLWEEQRKQRAQVAFECDE---DKDEREAPPREGNLKRYPTPYPDELKNMVKTV 498
+ W + R V + D+D EA + L+R TP+P ELK M +++
Sbjct: 429 QQGSLSETWSDAPPSRVSVIQFLEAPIGDEDAEEAAAEKRGLQRRATPHPSELKVMKRSI 488
Query: 499 QTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTTTVKSKVDEREKYMIGNSV 558
+ R + DSG L P E+++ ++ + G+ SE + S V E E
Sbjct: 489 EG--RRSEACPCQPDSGSPL-PAEEEKRLSAESGL--SEDSRPSASTVSEAEPEGPSAEA 543
Query: 559 QKISEPEAEISPG 571
Q S+ EA + G
Sbjct: 544 QGGSQQEATTAGG 556
Score = 63.2 bits (152), Expect = 2e-09
Identities = 32/79 (40%), Positives = 51/79 (64%), Gaps = 3/79 (3%)
Query: 1291 LGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKL-LQPGDKIIQANGYSFINIEHGQ 1349
LG SI+GG G P++ DD+GIF++RV EGPA++ ++ GDK+++ NG + EH +
Sbjct: 738 LGISIAGGKGS--TPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLEVNGVALQGAEHHE 795
Query: 1350 AVSLLKTFQNTVELIIVRE 1368
AV L+ V++ + RE
Sbjct: 796 AVEALRGAGTAVQMRVWRE 814
Score = 62.4 bits (150), Expect = 3e-09
Identities = 37/105 (35%), Positives = 52/105 (49%), Gaps = 4/105 (3%)
Query: 1266 PHCSPRQGHELAKQEIRVRVEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPAS 1325
P P L ++ + + LGFSI+GG G P+R D GIFV+R+ G A
Sbjct: 847 PLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGS--TPYRAGDAGIFVSRIAEGGAAH 904
Query: 1326 KL--LQPGDKIIQANGYSFINIEHGQAVSLLKTFQNTVELIIVRE 1368
+ LQ GD+++ NG H AVSLL T+ L++ RE
Sbjct: 905 RAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLERE 949
Score = 61.2 bits (147), Expect = 6e-09
Identities = 31/90 (34%), Positives = 55/90 (61%), Gaps = 3/90 (3%)
Query: 1279 QEIRVRVEKDPELGFSISGGVGGR-GNPFRPDDDGIFVTRVQPEGPASK--LLQPGDKII 1335
+E+ ++ LG SI GG G GNP P D+GIF+++V P G A + L+ G +++
Sbjct: 1099 RELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLL 1158
Query: 1336 QANGYSFINIEHGQAVSLLKTFQNTVELII 1365
+ N S + + HG+AV LL++ +T+ +++
Sbjct: 1159 EVNQQSLLGLTHGEAVQLLRSVGDTLTVLV 1188
Score = 48.1 bits (113), Expect = 6e-05
Identities = 29/77 (37%), Positives = 44/77 (57%), Gaps = 2/77 (2%)
Query: 1279 QEIRVRVEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKL-LQPGDKIIQA 1337
+EIR+ P LG SI GG +PF + G+F+++V P G A++ L+ GD+I+
Sbjct: 1003 EEIRLPRAGGP-LGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVGDRILAV 1061
Query: 1338 NGYSFINIEHGQAVSLL 1354
NG + H +AVS L
Sbjct: 1062 NGQDVRDATHQEAVSAL 1078
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 389 bits (998), Expect = e-107
Identities = 225/553 (40%), Positives = 333/553 (60%), Gaps = 15/553 (2%)
Query: 24 VTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTT 83
V ++D HCSL+ VP+EI+ + ++LEEL LDANQ+ ELPK F +L KL L DN++
Sbjct: 14 VESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQR 73
Query: 84 LPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQL 143
LP +AN + L ELDVS+N I E PE+IK CK L I + S NP+S+LPDGF+QL +L L
Sbjct: 74 LPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHL 133
Query: 144 YLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVL 203
LND L+ LP + G L L LELREN LK LP +++ L +LE+LDLG N+ +P+ L
Sbjct: 134 ALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTL 193
Query: 204 EQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSN 263
L L+E W+D N+L+ +P +G+L++L LDVS+N +E + + L DLLLS N
Sbjct: 194 GALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQN 253
Query: 264 SLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTN 323
L++LP+ IG LK ++ LK+D+N+L + ++IG ++ EL + N + ALP S+G+LT
Sbjct: 254 LLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTK 313
Query: 324 LRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNL 383
L D N+L+ LPPEIG ++VL L N+L LP E+ +L V++++ NRL++L
Sbjct: 314 LTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSL 373
Query: 384 PFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQP--RTEDVMFISD 441
PF+ T L L A+WL++NQ++P++ Q E D+ T + VLT Y+ PQQP ED +
Sbjct: 374 PFALTHL-NLKALWLAENQAQPMLRFQTEDDARTGEKVLTCYLLPQQPPLSLED----AG 428
Query: 442 NESFNPSLWEEQRKQRAQVAFECDE---DKDEREAPPREGNLKRYPTPYPDELKNMVKTV 498
+ W + R V + D+D EA + L+R TP+P ELK M +++
Sbjct: 429 QQGSLSETWSDAPPSRVSVIQFLEAPIGDEDAEEAAAEKRGLQRRATPHPSELKVMKRSI 488
Query: 499 QTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTTTVKSKVDEREKYMIGNSV 558
+ R + DSG L P E+++ ++ + G+ SE + S V E E
Sbjct: 489 EG--RRSEACPCQPDSGSPL-PAEEEKRLSAESGL--SEDSRPSASTVSEAEPEGPSAEA 543
Query: 559 QKISEPEAEISPG 571
Q S+ EA + G
Sbjct: 544 QGGSQQEATTAGG 556
Score = 63.2 bits (152), Expect = 2e-09
Identities = 32/79 (40%), Positives = 51/79 (64%), Gaps = 3/79 (3%)
Query: 1291 LGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKL-LQPGDKIIQANGYSFINIEHGQ 1349
LG SI+GG G P++ DD+GIF++RV EGPA++ ++ GDK+++ NG + EH +
Sbjct: 738 LGISIAGGKGS--TPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLEVNGVALQGAEHHE 795
Query: 1350 AVSLLKTFQNTVELIIVRE 1368
AV L+ V++ + RE
Sbjct: 796 AVEALRGAGTAVQMRVWRE 814
Score = 62.4 bits (150), Expect = 3e-09
Identities = 37/105 (35%), Positives = 52/105 (49%), Gaps = 4/105 (3%)
Query: 1266 PHCSPRQGHELAKQEIRVRVEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPAS 1325
P P L ++ + + LGFSI+GG G P+R D GIFV+R+ G A
Sbjct: 847 PLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGS--TPYRAGDAGIFVSRIAEGGAAH 904
Query: 1326 KL--LQPGDKIIQANGYSFINIEHGQAVSLLKTFQNTVELIIVRE 1368
+ LQ GD+++ NG H AVSLL T+ L++ RE
Sbjct: 905 RAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLERE 949
Score = 61.2 bits (147), Expect = 6e-09
Identities = 31/90 (34%), Positives = 55/90 (61%), Gaps = 3/90 (3%)
Query: 1279 QEIRVRVEKDPELGFSISGGVGGR-GNPFRPDDDGIFVTRVQPEGPASK--LLQPGDKII 1335
+E+ ++ LG SI GG G GNP P D+GIF+++V P G A + L+ G +++
Sbjct: 1099 RELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLL 1158
Query: 1336 QANGYSFINIEHGQAVSLLKTFQNTVELII 1365
+ N S + + HG+AV LL++ +T+ +++
Sbjct: 1159 EVNQQSLLGLTHGEAVQLLRSVGDTLTVLV 1188
Score = 48.1 bits (113), Expect = 6e-05
Identities = 29/77 (37%), Positives = 44/77 (57%), Gaps = 2/77 (2%)
Query: 1279 QEIRVRVEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKL-LQPGDKIIQA 1337
+EIR+ P LG SI GG +PF + G+F+++V P G A++ L+ GD+I+
Sbjct: 1003 EEIRLPRAGGP-LGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVGDRILAV 1061
Query: 1338 NGYSFINIEHGQAVSLL 1354
NG + H +AVS L
Sbjct: 1062 NGQDVRDATHQEAVSAL 1078
>gi|95113664 leucine rich repeat containing 1 [Homo sapiens]
Length = 524
Score = 375 bits (962), Expect = e-103
Identities = 213/514 (41%), Positives = 308/514 (59%), Gaps = 16/514 (3%)
Query: 24 VTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTT 83
V ++D HCSL VP+EI+ + ++LEEL LDANQ+ ELP+Q F L KL L DN++
Sbjct: 14 VESIDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQR 73
Query: 84 LPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQL 143
LP IAN + L ELDVS+N I E PE+I CK L + + S NP+++LP+ F +L NLT L
Sbjct: 74 LPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTCL 133
Query: 144 YLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVL 203
+ND L+ LP N G L L LELREN L LP ++ +L +LE LDLG+NE +PE +
Sbjct: 134 SVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESI 193
Query: 204 EQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSN 263
L LK+ W+D N+L+ +P IG+LK L LDVS+N +E + E IS +L DL++S N
Sbjct: 194 GALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQN 253
Query: 264 SLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTN 323
L+ +P+ IG LK ++ LK+D+N+L LP+++G S+ EL + N++ LP SIG+L
Sbjct: 254 LLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKK 313
Query: 324 LRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNL 383
L AD N L LP EIG ++TV + N+L +P E+ +L V++++ NRL +L
Sbjct: 314 LSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHL 373
Query: 384 PFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQPR----TEDVMFI 439
P S T L +L A+WLSDNQS+PL+ Q +TD T + +LT + PQ P E++
Sbjct: 374 PLSLTAL-KLKALWLSDNQSQPLLTFQTDTDYTTGEKILTCVLLPQLPSEPTCQENLPRC 432
Query: 440 SDNESF----NPSLWEEQRKQRAQVAFECDEDKDEREAPPREGNLKRYPTPYPDELKNMV 495
E+ + W E+ R +++KDE + R L R TP+P ELK+M
Sbjct: 433 GALENLVNDVSDEAWNERAVNRVSAIRFVEDEKDEEDNETR--TLLRRATPHPGELKHMK 490
Query: 496 KTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINK 529
KTV+ + + N G D +E I++
Sbjct: 491 KTVENL-----RNDMNAAKGLDSNKNEVNHAIDR 519
>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
Length = 582
Score = 190 bits (482), Expect = 9e-48
Identities = 132/453 (29%), Positives = 208/453 (45%), Gaps = 50/453 (11%)
Query: 21 EETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDND 80
EE LD S S+ +P I + L ELYL +N+++ LP ++ +L L+L +N
Sbjct: 99 EENSMRLDLSKRSIHILPSSIKELTQ-LTELYLYSNKLQSLPAEVGCLVNLMTLALSENS 157
Query: 81 LTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNL 140
LT+LP S+ NL LR LD+ N ++E P + LT + N I+ + L L
Sbjct: 158 LTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKL 217
Query: 141 TQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVP 200
+ L + + ++ LPA G L L L++ NQL+ LPK + TQ+ LDL NE ++P
Sbjct: 218 SMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLP 277
Query: 201 EVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGI----------- 249
+ + LS L + NRL+ IP + L L++ NNI + E +
Sbjct: 278 DTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLT 337
Query: 250 --------------------------------------STCENLQDLLLSSNSLQQLPET 271
S + L L + N L LP
Sbjct: 338 LARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLD 397
Query: 272 IGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADH 331
G+ ++ L + NQL +P+ + GL+S+E L S N ++ LP +G L LR +
Sbjct: 398 FGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEE 457
Query: 332 NYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQ 391
N L+ LP EI K++ L L +N+L TLP +G + L + L +N L +LP L+
Sbjct: 458 NKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLE 517
Query: 392 QLTAMWLSDNQSKPLIPLQKETDSETQKMVLTN 424
L ++L+DN + +P + S+ M + N
Sbjct: 518 NLEELYLNDNPNLHSLPFELALCSKLSIMSIEN 550
Score = 177 bits (450), Expect = 5e-44
Identities = 115/385 (29%), Positives = 195/385 (50%), Gaps = 28/385 (7%)
Query: 27 LDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPA 86
LD H L ++P ++ + +L LYL N+I + K + N L LS+ +N + LPA
Sbjct: 174 LDLRHNKLREIPSVVYRLD-SLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLPA 232
Query: 87 SIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLN 146
I L NL LDV+ N ++ P+ I NC +T ++ N + LPD L +L++L L
Sbjct: 233 EIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLSRLGLR 292
Query: 147 DAFLEFLPANFGRLTKLQILELRENQLKMLPKTM-NRLTQLERLDLGSNEFTEVPE---- 201
L +P + + + L+ L L N + LP+++ + L +L L L N F P
Sbjct: 293 YNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPS 352
Query: 202 ---------------------VLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN 240
+ + L + M N+LT +P G+ + L+++ N
Sbjct: 353 QFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATN 412
Query: 241 NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLIS 300
+ + E +S +L+ L+LS+N L++LP +G+L+ + L ++EN+L LP+ I L
Sbjct: 413 QLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKD 472
Query: 301 VEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSN-KLET 359
+++L + N++ LP IG LTNL N L LP EIG+ +N+ L+L+ N L +
Sbjct: 473 LQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHS 532
Query: 360 LPEEMGDMQKLKVINLSDNRLKNLP 384
LP E+ KL ++++ + L +LP
Sbjct: 533 LPFELALCSKLSIMSIENCPLSHLP 557
Score = 159 bits (403), Expect = 1e-38
Identities = 114/389 (29%), Positives = 182/389 (46%), Gaps = 50/389 (12%)
Query: 93 NLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEF 152
N LD+SK I P +IK LT + N + LP L+NL L L++ L
Sbjct: 101 NSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTS 160
Query: 153 LPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEF 212
LP + L KL++L+LR N+L+ +P + RL L L L N T V + ++ LS L
Sbjct: 161 LPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSML 220
Query: 213 WMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETI 272
+ N++ +P IG L L LDV+ N +E + + I C + +L L N L LP+TI
Sbjct: 221 SIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTI 280
Query: 273 GSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSI-------------- 318
G+L +++ L + N+L +P S+ ++EEL+ N + LP S+
Sbjct: 281 GNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLAR 340
Query: 319 -----------GQLTNLRTFAADH------------------------NYLQQLPPEIGS 343
Q + + + +H N L LP + G+
Sbjct: 341 NCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGT 400
Query: 344 WKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQS 403
W ++ L L +N+L +PE++ + L+V+ LS+N LK LP L++L + L +N+
Sbjct: 401 WTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKL 460
Query: 404 KPLIPLQKETDSETQKMVLTNYMFPQQPR 432
+ L P + + QK+VLTN PR
Sbjct: 461 ESL-PNEIAYLKDLQKLVLTNNQLTTLPR 488
Score = 154 bits (388), Expect = 7e-37
Identities = 106/327 (32%), Positives = 172/327 (52%), Gaps = 5/327 (1%)
Query: 19 GEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPD 78
GE + TLD +H LE +PKEI + + L L N++ +LP + N SL +L L
Sbjct: 235 GELCNLITLDVAHNQLEHLPKEIGNCTQ-ITNLDLQHNELLDLPDTIGNLSSLSRLGLRY 293
Query: 79 NDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKV-LTIVEASVNPISKLP-DGFSQ 136
N L+ +P S+A L EL++ N I PE++ + V L + + N P G SQ
Sbjct: 294 NRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQ 353
Query: 137 LLNLTQLYLNDAFLEFLPAN-FGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNE 195
+ L + + +P F R L L +++NQL LP T + L+L +N+
Sbjct: 354 FSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQ 413
Query: 196 FTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENL 255
T++PE + L L+ + N L +P +G+L++L LD+ +N +E + I+ ++L
Sbjct: 414 LTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDL 473
Query: 256 QDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFN-EVEAL 314
Q L+L++N L LP IG L N+T L + EN L +LP+ IG L ++EEL + N + +L
Sbjct: 474 QKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSL 533
Query: 315 PSSIGQLTNLRTFAADHNYLQQLPPEI 341
P + + L + ++ L LPP+I
Sbjct: 534 PFELALCSKLSIMSIENCPLSHLPPQI 560
Score = 146 bits (368), Expect = 2e-34
Identities = 101/322 (31%), Positives = 162/322 (50%), Gaps = 10/322 (3%)
Query: 120 VEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKT 179
++ S I LP +L LT+LYL L+ LPA G L L L L EN L LP +
Sbjct: 105 LDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDS 164
Query: 180 MNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSK 239
++ L +L LDL N+ E+P V+ +L L ++ NR+T + I +L +L+ L + +
Sbjct: 165 LDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRE 224
Query: 240 NNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLI 299
N I+ + I NL L ++ N L+ LP+ IG+ IT L + N+L+ LPD+IG L
Sbjct: 225 NKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLS 284
Query: 300 SVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPE-IGSWKNITVLFLHSNKLE 358
S+ L +N + A+P S+ + + L ++N + LP + S + L L N +
Sbjct: 285 SLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQ 344
Query: 359 TLPEEMGDMQKLKVI---NLSDNRLKNLPFS-FTKLQQLTAMWLSDNQSKPLIPLQKETD 414
P +G + I N+ NR+ +PF F++ + L+ + + DNQ L PL T
Sbjct: 345 LYP--VGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSL-PLDFGTW 401
Query: 415 SETQKMVLTNYMFPQQPRTEDV 436
+ ++ L + P EDV
Sbjct: 402 TSMVELNLATNQLTKIP--EDV 421
>gi|122937315 leucine-rich repeats and IQ motif containing 4 [Homo
sapiens]
Length = 560
Score = 173 bits (439), Expect = 9e-43
Identities = 118/420 (28%), Positives = 206/420 (49%), Gaps = 12/420 (2%)
Query: 23 TVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLF-NCQSLHKLSLPDNDL 81
++ +LD S+ + + +F L EL L ++E+P +F N L L L N L
Sbjct: 95 SLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHL 154
Query: 82 TTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLT 141
LP I N LRE+ + +N + FP+ + L I++ N I +P+ L L
Sbjct: 155 KCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGHLTGLQ 214
Query: 142 QLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPE 201
+ Y+ L LPA+ + ++L +L+L N L +PK+ L ++ + L N +VP
Sbjct: 215 KFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPR 274
Query: 202 VLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLS 261
++ + + L ++ L + G L L +LD+S+N++ I +NL+ L L
Sbjct: 275 LICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLD 334
Query: 262 SNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEEL----DCSFNEVEALPSS 317
N + QLP +GSL + L + N+ + P+ + L S+E+L D F ++ +P
Sbjct: 335 DNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGF-KLTYVPEH 393
Query: 318 IGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSD 377
I +L +L+ ++N+L+ LP +GS N+ VL N L+ LP+ + Q LK + L D
Sbjct: 394 IRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLED 453
Query: 378 NRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQPRTEDVM 437
N L +LP + L L + L DN P+ KE +E + + + + ++ R ++M
Sbjct: 454 NLLTHLPENLDSLVNLKVLTLMDN---PMEEPPKEVCAEGNEAI---WKYLKENRNRNIM 507
Score = 165 bits (417), Expect = 3e-40
Identities = 114/382 (29%), Positives = 196/382 (51%), Gaps = 10/382 (2%)
Query: 27 LDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPA 86
+D S+ SL +P EIFTF + LEE++L+ NQIEE+P+++ +++ L L N+L +L
Sbjct: 30 IDASNQSLTAIPLEIFTFTE-LEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCP 88
Query: 87 SIANLINLRELDVSKNGIQEFPENIKN----CKVLTIVEASVNPISKLPDGFSQLLNLTQ 142
++ L +L LD+S N I + + + L + + + I + F L +L
Sbjct: 89 ALGLLSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVI--FKNLHHLEL 146
Query: 143 LYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEV 202
L L L+ LP TKL+ + L+ NQ ++ P+ + L LE +DL N+ +PE
Sbjct: 147 LGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEE 206
Query: 203 LEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSS 262
+ L+GL++F+M +N L +P + QL+ LD+S N + + + + + ++ LS
Sbjct: 207 IGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSG 266
Query: 263 NSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLT 322
N L+++P I ++ L + L L S L+++ LD S N + P I L
Sbjct: 267 NRLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALK 326
Query: 323 NLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEE---MGDMQKLKVINLSDNR 379
NL D N + QLP E+GS + +L L N+ + PEE + ++KL + +
Sbjct: 327 NLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFK 386
Query: 380 LKNLPFSFTKLQQLTAMWLSDN 401
L +P KLQ L +++ +N
Sbjct: 387 LTYVPEHIRKLQSLKELYIENN 408
Score = 158 bits (400), Expect = 3e-38
Identities = 108/362 (29%), Positives = 182/362 (50%), Gaps = 7/362 (1%)
Query: 34 LEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLIN 93
L+ +PKEI K L E+YL NQ E P++L +L + L +N + +P I +L
Sbjct: 154 LKCLPKEIVNQTK-LREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGHLTG 212
Query: 94 LRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFL 153
L++ ++ N + P ++ C L++++ S N + +P F++L +T++ L+ LE +
Sbjct: 213 LQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKV 272
Query: 154 PANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFW 213
P R T L +L L L L + L L LDL N P + L L+
Sbjct: 273 PRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLG 332
Query: 214 MDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNS---LQQLPE 270
+D N++ +P +GSL +L L ++ N E + + +L+ L + + L +PE
Sbjct: 333 LDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPE 392
Query: 271 TIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAAD 330
I L+++ L I+ N L YLP S+G + ++E LDC N ++ LP +I Q L+ +
Sbjct: 393 HIRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLE 452
Query: 331 HNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEM-GDMQKLKVINLSDNRLKNLPFSFTK 389
N L LP + S N+ VL L N +E P+E+ + + L +NR +N+ TK
Sbjct: 453 DNLLTHLPENLDSLVNLKVLTLMDNPMEEPPKEVCAEGNEAIWKYLKENRNRNI--MATK 510
Query: 390 LQ 391
+Q
Sbjct: 511 IQ 512
>gi|238908508 leucine-rich repeat and death domain-containing
protein [Homo sapiens]
Length = 860
Score = 170 bits (431), Expect = 8e-42
Identities = 118/396 (29%), Positives = 188/396 (47%), Gaps = 27/396 (6%)
Query: 24 VTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTT 83
+ L + LE + +I F + L L LD N ++ +P+++ C L LSL DN LT
Sbjct: 351 IKELQLADNKLEVISHKIENFRE-LRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTE 409
Query: 84 LPASIANLINLRELDVSKNG-----------------------IQEFPENIKNCKVLTIV 120
LP I L NLR+L V++N I + P IKNC+ + +
Sbjct: 410 LPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKI 469
Query: 121 EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM 180
E S N I P G L +L L +N ++ +P + +L LEL EN+L + +
Sbjct: 470 ELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHF 529
Query: 181 NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN 240
L L+ LDLG N+ ++P + + L + N+ P + +L+ L LD+S+N
Sbjct: 530 CSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSEN 589
Query: 241 NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDE---NQLMYLPDSIGG 297
++ + I + +Q L SSN P + L+++ L I + +L LP +
Sbjct: 590 QLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSN 649
Query: 298 LISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKL 357
+ ++ELD S N + +P +IG+L NL + A +N + LPP + S ++ L L N L
Sbjct: 650 MTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNL 709
Query: 358 ETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQL 393
LP + ++ LK IN DN L P K +QL
Sbjct: 710 TALPSAIYNIFSLKEINFDDNPLLRPPVEICKGKQL 745
Score = 154 bits (389), Expect = 6e-37
Identities = 108/399 (27%), Positives = 190/399 (47%), Gaps = 24/399 (6%)
Query: 27 LDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPA 86
L+ SH + +PKEI + +L+ N IE P L +L LSL N L +P
Sbjct: 216 LNVSHNHISHIPKEISQLGN-IRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRHIPD 274
Query: 87 SIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLN 146
++ +L LR L++ N + FP+ + L ++ + N IS LP +L NL L ++
Sbjct: 275 TLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMD 334
Query: 147 DAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQL 206
L FL +L K++ L+L +N+L+++ + +L L L N +PE +
Sbjct: 335 HNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCC 394
Query: 207 SGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQ 266
+ L+ + N+LT +P +I L L L V++NN+ + + IS N+ L S N +
Sbjct: 395 AMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIIT 454
Query: 267 QLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIG------- 319
+P I + + I +++ N++MY P + L S+ L + N + +P I
Sbjct: 455 DVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLH 514
Query: 320 ----------------QLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEE 363
L NL+ N ++++P I + ++ VL L NK ET P E
Sbjct: 515 LELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRE 574
Query: 364 MGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQ 402
+ ++ L+V++LS+N+L+ + L+ + + S NQ
Sbjct: 575 LCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQ 613
Score = 150 bits (378), Expect = 1e-35
Identities = 119/424 (28%), Positives = 193/424 (45%), Gaps = 48/424 (11%)
Query: 26 TLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELP-KQLFNCQSLHKLSLPDNDLTTL 84
T++ L++ PK+I K ++ LYLD NQI+ + L LSL +N L++L
Sbjct: 145 TVNLEAKGLQEFPKDILKI-KYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSL 203
Query: 85 PASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLY 144
P+ I L NLR L+VS N I P+ I + + N I P L NL L
Sbjct: 204 PSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILS 263
Query: 145 LNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLE 204
L L +P L L++L L NQL PK + L +L LDL N + +P+ +
Sbjct: 264 LGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIR 323
Query: 205 QLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVE------------------ 246
+L L+ MD N+LTF+ I L ++ L ++ N +E++
Sbjct: 324 ELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNL 383
Query: 247 -----EGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSI------ 295
E IS C L+ L LS N L +LP+ I L N+ L ++ N ++ + D I
Sbjct: 384 LKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNI 443
Query: 296 ------GGLIS-----------VEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLP 338
G +I+ + +++ S+N++ P + L +L + + NY+ ++P
Sbjct: 444 CSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIP 503
Query: 339 PEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWL 398
+I K + L L NKL E + LK ++L N++K +P S + + L + L
Sbjct: 504 VDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLIL 563
Query: 399 SDNQ 402
N+
Sbjct: 564 CCNK 567
>gi|110825984 malignant fibrous histiocytoma amplified sequence 1
[Homo sapiens]
Length = 1052
Score = 150 bits (380), Expect = 6e-36
Identities = 100/292 (34%), Positives = 146/292 (50%), Gaps = 2/292 (0%)
Query: 1 MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEE 60
+ +R+ F RL P G +T LD SH L + E+ + + L +L L NQ+
Sbjct: 92 LVLRRNRFARLPPAVAELGHH--LTELDVSHNRLTALGAEVVSALRELRKLNLSHNQLPA 149
Query: 61 LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIV 120
LP QL L +L + N L LP S++ L LR LDV N + FP + L +
Sbjct: 150 LPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEEL 209
Query: 121 EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM 180
+ S N + LP+ S L L L+L+ A L LPA F L L+ L L N L+ LP
Sbjct: 210 DVSSNRLRGLPEDISALRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQF 269
Query: 181 NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN 240
+ L +L+ L+L SN F E P L L+GL+E ++ N+LT +P I L +L L + N
Sbjct: 270 SCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNN 329
Query: 241 NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLP 292
I + + I L++L+L N + LP+ G L + KI +N L+ P
Sbjct: 330 RIRYLPDSIVELTGLEELVLQGNQIAVLPDHFGQLSRVGLWKIKDNPLIQPP 381
Score = 137 bits (344), Expect = 9e-32
Identities = 106/340 (31%), Positives = 164/340 (48%), Gaps = 24/340 (7%)
Query: 48 LEELYLDANQIEELPKQLFNCQ-SLHKLSLPDNDLTTLPASIANL-INLRELDVSKNGIQ 105
+E L L N +EE+P+ L + SL L L N LP ++A L +L ELDVS N
Sbjct: 65 IEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNR-- 122
Query: 106 EFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQI 165
LT + A V S L L +L L+ L LPA G L L+
Sbjct: 123 -----------LTALGAEV---------VSALRELRKLNLSHNQLPALPAQLGALAHLEE 162
Query: 166 LELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGF 225
L++ N+L LP +++ L++L LD+ N+ T P L QL L+E + +NRL +P
Sbjct: 163 LDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPED 222
Query: 226 IGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDE 285
I +L+ L L +S + + G +L+ L+L +N LQ LP L+ + L +
Sbjct: 223 ISALRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSS 282
Query: 286 NQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWK 345
N P ++ L +EEL S N++ ++PS I L L T D+N ++ LP I
Sbjct: 283 NLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELT 342
Query: 346 NITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPF 385
+ L L N++ LP+ G + ++ + + DN L P+
Sbjct: 343 GLEELVLQGNQIAVLPDHFGQLSRVGLWKIKDNPLIQPPY 382
Score = 134 bits (337), Expect = 6e-31
Identities = 95/320 (29%), Positives = 156/320 (48%), Gaps = 2/320 (0%)
Query: 24 VTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNC-QSLHKLSLPDNDLT 82
+ L+ + LE+VP+ + + +L L L N+ LP + L +L + N LT
Sbjct: 65 IEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLT 124
Query: 83 TLPASIANLIN-LRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLT 141
L A + + + LR+L++S N + P + L ++ S N ++ LPD S L L
Sbjct: 125 ALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLR 184
Query: 142 QLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPE 201
L ++ L P +L L+ L++ N+L+ LP+ ++ L L+ L L E +P
Sbjct: 185 TLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPA 244
Query: 202 VLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLS 261
+L+ L+ +D N L +P L++L L++S N E + L++L LS
Sbjct: 245 GFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLS 304
Query: 262 SNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQL 321
N L +P I L + TL +D N++ YLPDSI L +EEL N++ LP GQL
Sbjct: 305 RNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDHFGQL 364
Query: 322 TNLRTFAADHNYLQQLPPEI 341
+ + + N L Q P E+
Sbjct: 365 SRVGLWKIKDNPLIQPPYEV 384
Score = 129 bits (324), Expect = 2e-29
Identities = 102/337 (30%), Positives = 162/337 (48%), Gaps = 9/337 (2%)
Query: 74 LSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCK-VLTIVEASVNPISKLPD 132
L P + LPA NL ++ L++ NG++E PE + + L ++ N ++LP
Sbjct: 48 LESPASPQLVLPA---NLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPP 104
Query: 133 GFSQL-LNLTQLYLNDAFLEFLPANF-GRLTKLQILELRENQLKMLPKTMNRLTQLERLD 190
++L +LT+L ++ L L A L +L+ L L NQL LP + L LE LD
Sbjct: 105 AVAELGHHLTELDVSHNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELD 164
Query: 191 LGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGIS 250
+ N +P+ L LS L+ +D N+LT P + L L LDVS N + + E IS
Sbjct: 165 VSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDIS 224
Query: 251 TCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNE 310
L+ L LS L LP L ++ +L +D N L LP L ++ L+ S N
Sbjct: 225 ALRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNL 284
Query: 311 VEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKL 370
E P+++ L L N L +P I + L+L +N++ LP+ + ++ L
Sbjct: 285 FEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGL 344
Query: 371 KVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLI 407
+ + L N++ LP F +L ++ + DN PLI
Sbjct: 345 EELVLQGNQIAVLPDHFGQLSRVGLWKIKDN---PLI 378
>gi|21361633 leucine rich repeat containing 40 [Homo sapiens]
Length = 602
Score = 149 bits (375), Expect = 2e-35
Identities = 118/377 (31%), Positives = 187/377 (49%), Gaps = 46/377 (12%)
Query: 48 LEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEF 107
L +L + N+++ L L +L L + DN LT+LP++I L NL++L+VS N ++
Sbjct: 84 LTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKIL 143
Query: 108 PENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILE 167
PE I N + L + N ++ + +GF QL NL L L++ L +PA+F L+ L L
Sbjct: 144 PEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLN 203
Query: 168 LRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIG 227
L N+LK LP +NR+ +L+ LD SN +P L + L+ ++ N+L F+P F
Sbjct: 204 LSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPEF-P 262
Query: 228 SLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQ 287
S L L V +N IEM+E E + L +I L + +N+
Sbjct: 263 SCSLLKELHVGENQIEMLE----------------------AEHLKHLNSILVLDLRDNK 300
Query: 288 LMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNI 347
L +PD I L S+E LD S N++ +LP S+G L +L+ A + N L+ + EI S
Sbjct: 301 LKSVPDEIILLRSLERLDLSNNDISSLPYSLGNL-HLKFLALEGNPLRTIRREIISKGTQ 359
Query: 348 TVLFLHSNKLE---------------TLPEE----MGDMQKLKVINLSDNRLKNLP---F 385
VL +K++ TLP E + + LK+++ SD + +P F
Sbjct: 360 EVLKYLRSKIKDDGPSQSESATETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVF 419
Query: 386 SFTKLQQLTAMWLSDNQ 402
K +T++ S NQ
Sbjct: 420 DAVKSNIVTSINFSKNQ 436
Score = 132 bits (332), Expect = 2e-30
Identities = 122/442 (27%), Positives = 208/442 (47%), Gaps = 39/442 (8%)
Query: 20 EEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDN 79
E E + L+ SH L+ +P+EI T + L+ LYL N++ + + +L L L +N
Sbjct: 126 ELENLQKLNVSHNKLKILPEEI-TNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNN 184
Query: 80 DLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLN 139
LTT+PAS ++L +L L++S N ++ P I K L ++ + N + +P + + +
Sbjct: 185 HLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMES 244
Query: 140 LTQLYLNDAFLEFLPA-----------------------NFGRLTKLQILELRENQLKML 176
L LYL L FLP + L + +L+LR+N+LK +
Sbjct: 245 LELLYLRRNKLRFLPEFPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSV 304
Query: 177 PKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLD 236
P + L LERLDL +N+ + +P L L LK ++ N L I I S L
Sbjct: 305 PDEIILLRSLERLDLSNNDISSLPYSLGNLH-LKFLALEGNPLRTIRREIISKGTQEVLK 363
Query: 237 VSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKI---DENQLMYLPD 293
++ I+ ++G S E+ + ++ S E+ ++ I TLKI + Q +PD
Sbjct: 364 YLRSKIK--DDGPSQSESATETAMTLPS-----ESRVNIHAIITLKILDYSDKQATLIPD 416
Query: 294 SIGGLIS---VEELDCSFNEVEALPSSIGQLTNLRTFA-ADHNYLQQLPPEIGSWKNITV 349
+ + V ++ S N++ +P + +L + + N L + E+ + +T
Sbjct: 417 EVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTF 476
Query: 350 LFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPL 409
L L +N L +LPEEM + +L+ INLS NR K LP ++ L + +S+NQ + P
Sbjct: 477 LDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQ 536
Query: 410 QKETDSETQKMVLTNYMFPQQP 431
+ + + L N Q P
Sbjct: 537 KMKMMENLTTLDLQNNDLLQIP 558
Score = 125 bits (313), Expect = 4e-28
Identities = 94/328 (28%), Positives = 166/328 (50%), Gaps = 6/328 (1%)
Query: 96 ELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPA 155
+L++S + E P+ + V EA+ N + + + +LT+L +++ L+ L
Sbjct: 40 QLNLSGRNLSEVPQCVWRINVDIPEEANQNLSFGATERWWEQTDLTKLIISNNKLQSLTD 99
Query: 156 NFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMD 215
+ L L +L++ +NQL LP + L L++L++ N+ +PE + L LK ++
Sbjct: 100 DLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPEEITNLRNLKCLYLQ 159
Query: 216 ANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSL 275
N LT I L L LD+S N++ V S+ +L L LSSN L+ LP I +
Sbjct: 160 HNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRM 219
Query: 276 KNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQ 335
K + L + N L +P + G+ S+E L N++ LP + L+ N ++
Sbjct: 220 KRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLP-EFPSCSLLKELHVGENQIE 278
Query: 336 QLPPE-IGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLT 394
L E + +I VL L NKL+++P+E+ ++ L+ ++LS+N + +LP+S L L
Sbjct: 279 MLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNL-HLK 337
Query: 395 AMWLSDNQSKPLIPLQKETDSETQKMVL 422
+ L N PL +++E S+ + VL
Sbjct: 338 FLALEGN---PLRTIRREIISKGTQEVL 362
Score = 97.8 bits (242), Expect = 6e-20
Identities = 96/381 (25%), Positives = 175/381 (45%), Gaps = 28/381 (7%)
Query: 23 TVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLT 82
++ L+ S L+ +P EI K L+ L ++N +E +P +L +SL L L N L
Sbjct: 198 SLVRLNLSSNELKSLPAEINRM-KRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLR 256
Query: 83 TLPASIANLINLRELDVSKNGIQEFP-ENIKNCKVLTIVEASVNPISKLPDGFSQLLNLT 141
LP + L+EL V +N I+ E++K+ + +++ N + +PD L +L
Sbjct: 257 FLP-EFPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLE 315
Query: 142 QLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERL--------DLGS 193
+L L++ + LP + G L L+ L L N L+ + + + E L D G
Sbjct: 316 RLDLSNNDISSLPYSLGNL-HLKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGP 374
Query: 194 NEFTEVPEVLEQLSG-----------LKEFWMDANRLTFIPGFIGSLKQ---LTYLDVSK 239
++ E L LK + T IP + + +T ++ SK
Sbjct: 375 SQSESATETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSK 434
Query: 240 NNI-EMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGL 298
N + E+ + + E + D+ LS N L + + L+ +T L + N L LP+ + L
Sbjct: 435 NQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESL 494
Query: 299 ISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPE-IGSWKNITVLFLHSNKL 357
+ ++ ++ SFN + LP + ++ L T +N + + P+ + +N+T L L +N L
Sbjct: 495 VRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDL 554
Query: 358 ETLPEEMGDMQKLKVINLSDN 378
+P E+G+ L+ + L N
Sbjct: 555 LQIPPELGNCVNLRTLLLDGN 575
Score = 41.2 bits (95), Expect = 0.007
Identities = 26/106 (24%), Positives = 54/106 (50%), Gaps = 2/106 (1%)
Query: 22 ETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDL 81
+ +T LD + L +P+E+ + + L+ + L N+ + LP+ L+ +L + + +N +
Sbjct: 472 QKLTFLDLRNNFLNSLPEEMESLVR-LQTINLSFNRFKMLPEVLYRIFTLETILISNNQV 530
Query: 82 TTL-PASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNP 126
++ P + + NL LD+ N + + P + NC L + NP
Sbjct: 531 GSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGNP 576
>gi|4503743 flightless I homolog [Homo sapiens]
Length = 1269
Score = 139 bits (350), Expect = 2e-32
Identities = 102/340 (30%), Positives = 178/340 (52%), Gaps = 8/340 (2%)
Query: 47 TLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQE 106
+L L L+ + LP++L Q L LS+ N+LTTL +++L +LR + N ++
Sbjct: 34 SLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRAIVARANSLKN 93
Query: 107 --FPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPAN-FGRLTKL 163
P++I L++++ S N +++ P N+ L L+ ++ +P F LT L
Sbjct: 94 SGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDL 153
Query: 164 QILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVP-EVLEQLSGLKEFWMDANRLT-- 220
L+L EN+L+ LP M RL L+ L L N L ++ L+ + + + T
Sbjct: 154 LYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQS 213
Query: 221 FIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITT 280
+P + L L +D+S N++ V E + T +L+ L LSSN + +L I ++ T
Sbjct: 214 NLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVET 273
Query: 281 LKIDENQLMYLPDSIGGLISVEELDCSFNEV--EALPSSIGQLTNLRTFAADHNYLQQLP 338
L + NQL LP +I L +++L + N++ + LPS IG+LTNL F A +N L+ +P
Sbjct: 274 LNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVP 333
Query: 339 PEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDN 378
+ + L L+ N L TLPE + + +++V+++ +N
Sbjct: 334 ESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVREN 373
Score = 131 bits (329), Expect = 5e-30
Identities = 110/352 (31%), Positives = 168/352 (47%), Gaps = 17/352 (4%)
Query: 27 LDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTT--L 84
L + L +P+E+ +K LE L + N + L +L + SL + N L +
Sbjct: 38 LKLNRTGLCYLPEELAALQK-LEHLSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGV 96
Query: 85 PASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDG-FSQLLNLTQL 143
P I L +L LD+S N + E P ++N K + ++ S N I +P+ F L +L L
Sbjct: 97 PDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYL 156
Query: 144 YLNDAFLEFLPANFGRLTKLQILELREN-----QLKMLPKTMNRLTQLERLDLGSNEFTE 198
L++ LE LP RL LQ L L N QL+ LP +T L+ L L S + T+
Sbjct: 157 DLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPA----MTALQTLHLRSTQRTQ 212
Query: 199 --VPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQ 256
+P LE LS L + + N LT +P + +L L L++S N I + I +++
Sbjct: 213 SNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVE 272
Query: 257 DLLLSSNSLQQLPETIGSLKNITTLKIDENQLMY--LPDSIGGLISVEELDCSFNEVEAL 314
L LS N L LP I L + L ++ N+L + LP IG L ++EE + N +E +
Sbjct: 273 TLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELV 332
Query: 315 PSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGD 366
P S+ + LR + N+L LP I I VL + N +P + D
Sbjct: 333 PESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLVMPPKPAD 384
Score = 119 bits (297), Expect = 3e-26
Identities = 84/279 (30%), Positives = 140/279 (50%), Gaps = 11/279 (3%)
Query: 22 ETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLF-NCQSLHKLSLPDND 80
+ ++ LD SH L + P+E+ K + L L N I+ +P QLF N L L L +N
Sbjct: 104 DDLSVLDLSHNQLTECPRELEN-AKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENR 162
Query: 81 LTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVE-----ASVNPISKLPDGFS 135
L +LP + L++L+ L ++ N + ++ +T ++ ++ S LP
Sbjct: 163 LESLPPQMRRLVHLQTLVLNGNPLLH--AQLRQLPAMTALQTLHLRSTQRTQSNLPTSLE 220
Query: 136 QLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNE 195
L NL + L+ L +P L L+ L L NQ+ L +++ +E L+L N+
Sbjct: 221 GLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQ 280
Query: 196 FTEVPEVLEQLSGLKEFWMDANRLTF--IPGFIGSLKQLTYLDVSKNNIEMVEEGISTCE 253
T +P + +LS LK+ ++++N+L F +P IG L L + NN+E+V E + C
Sbjct: 281 LTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCP 340
Query: 254 NLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLP 292
L+ L+L+ N L LPE I L I L + EN + +P
Sbjct: 341 KLRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLVMP 379
Score = 115 bits (287), Expect = 4e-25
Identities = 106/375 (28%), Positives = 176/375 (46%), Gaps = 27/375 (7%)
Query: 94 LRELDVSKNGIQE--FPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLE 151
+R +D+S N + FPEN+K L ++ + + LP+ + L L L ++ L
Sbjct: 10 VRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLT 69
Query: 152 FLPANFGRLTKLQILELRENQLKM--LPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGL 209
L L L+ + R N LK +P + +L L LDL N+ TE P LE +
Sbjct: 70 TLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNM 129
Query: 210 KEFWMDANRLTFIPG--FIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSN---- 263
+ N + IP FI +L L YLD+S+N +E + + +LQ L+L+ N
Sbjct: 130 LVLNLSHNSIDTIPNQLFI-NLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLH 188
Query: 264 -SLQQLPETIGSLKNITTLKIDENQLMY--LPDSIGGLISVEELDCSFNEVEALPSSIGQ 320
L+QLP ++ + TL + Q LP S+ GL ++ ++D S N++ +P +
Sbjct: 189 AQLRQLP----AMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYT 244
Query: 321 LTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRL 380
L +LR N + +L I W ++ L L N+L +LP + + KLK + L+ N+L
Sbjct: 245 LPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKL 304
Query: 381 --KNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQPRTEDVMF 438
LP KL L +++ N + L+P + +K+VL P E + F
Sbjct: 305 DFDGLPSGIGKLTNLEE-FMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLP--EAIHF 361
Query: 439 ISDNESF----NPSL 449
+++ E NP+L
Sbjct: 362 LTEIEVLDVRENPNL 376
>gi|65301141 PH domain and leucine rich repeat protein
phosphatase-like [Homo sapiens]
Length = 1323
Score = 124 bits (310), Expect = 8e-28
Identities = 114/376 (30%), Positives = 188/376 (50%), Gaps = 31/376 (8%)
Query: 47 TLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQE 106
TL EL L N +LP Q+ N +L L L N LTTLP + NL L L +S N +
Sbjct: 323 TLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEELGNLQQLSSLGISFNNFSQ 382
Query: 107 FPENIKNCKVLTIVEASVNPISKLPDGFSQLLN------LTQLYLNDAFLEFLPANFGRL 160
PE + +L V + N + L G +N L +L +E L N
Sbjct: 383 IPEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLKTMVIENLEGN---- 438
Query: 161 TKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSG--LKEFWMDANR 218
+ ++LR+N+L L ++ L LE+L G N+ E+ LSG L+ + +NR
Sbjct: 439 KHITHVDLRDNRLTDL--DLSSLCSLEQLHCGRNQLREL-----TLSGFSLRTLYASSNR 491
Query: 219 LTFIPGF-IGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKN 277
LT + + + SL LT+LD+S+N +E V + + ++ L +S N L ++P I S +
Sbjct: 492 LTAVNVYPVPSL--LTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEVPVRILSSLS 549
Query: 278 ITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSI-GQLTNLRTFAADHNYLQQ 336
+ L + N + LP + I +E LD N + LP ++ + NLR A N L+
Sbjct: 550 LRKLMLGHNHVQNLPTLVEH-IPLEVLDLQHNALTRLPDTLFSKALNLRYLNASANSLES 608
Query: 337 LPPEIGSWKNIT---VLFLHSNKL--ETLPEEMGDMQKLKVINLSDNRLKNLPFS-FTKL 390
LP ++++ +L+L +N L + +P +G + L++++L++N+L+ P S KL
Sbjct: 609 LPSACTGEESLSMLQLLYLTNNLLTDQCIPVLVGHLH-LRILHLANNQLQTFPASKLNKL 667
Query: 391 QQLTAMWLSDNQSKPL 406
+QL + LS N+ K +
Sbjct: 668 EQLEELNLSGNKLKTI 683
Score = 107 bits (268), Expect = 6e-23
Identities = 102/378 (26%), Positives = 170/378 (44%), Gaps = 32/378 (8%)
Query: 53 LDANQIEELPKQLFNCQSLHKLSLPDNDLTT-LPASIANLIN---LRELDVSKNGIQEFP 108
L +EE+P+ LF Q + L+L N + P + L L+ L++S N + FP
Sbjct: 256 LSCYSLEEVPEHLFYSQDITYLNLRHNFMQLERPGGLDTLYKFSQLKGLNLSHNKLGLFP 315
Query: 109 ENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILEL 168
+ LT + S N LP LLNL L L+ FL LP G L +L L +
Sbjct: 316 ILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEELGNLQQLSSLGI 375
Query: 169 RENQLKMLPKTMNRLTQLERLDLGSNEFTEVP-EVLEQLSGLKEFWMDANRL-TFIPGFI 226
N +P+ +LT L+R+ + N + VL +++ +K + N L T + +
Sbjct: 376 SFNNFSQIPEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLKTMVIENL 435
Query: 227 GSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKN--------- 277
K +T++D+ N + ++ +S+ +L+ L N L++L + SL+
Sbjct: 436 EGNKHITHVDLRDNRLTDLD--LSSLCSLEQLHCGRNQLRELTLSGFSLRTLYASSNRLT 493
Query: 278 ----------ITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTF 327
+T L + N L +PD +E LD S+N + +P I +LR
Sbjct: 494 AVNVYPVPSLLTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEVPVRILSSLSLRKL 553
Query: 328 AADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEM-GDMQKLKVINLSDNRLKNLPFS 386
HN++Q LP + + VL L N L LP+ + L+ +N S N L++LP +
Sbjct: 554 MLGHNHVQNLPTLV-EHIPLEVLDLQHNALTRLPDTLFSKALNLRYLNASANSLESLPSA 612
Query: 387 FT---KLQQLTAMWLSDN 401
T L L ++L++N
Sbjct: 613 CTGEESLSMLQLLYLTNN 630
Score = 98.6 bits (244), Expect = 4e-20
Identities = 85/273 (31%), Positives = 135/273 (49%), Gaps = 12/273 (4%)
Query: 24 VTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTT 83
+T LD S LE VP +K +E L + N + E+P ++ + SL KL L N +
Sbjct: 504 LTFLDLSRNLLECVPDWACEAKK-IEVLDVSYNLLTEVPVRILSSLSLRKLMLGHNHVQN 562
Query: 84 LPASIANLINLRELDVSKNGIQEFPENIKNCKV-LTIVEASVNPISKLPD---GFSQLLN 139
LP + + I L LD+ N + P+ + + + L + AS N + LP G L
Sbjct: 563 LPTLVEH-IPLEVLDLQHNALTRLPDTLFSKALNLRYLNASANSLESLPSACTGEESLSM 621
Query: 140 LTQLYLNDAFL--EFLPANFGRLTKLQILELRENQLKMLPKT-MNRLTQLERLDLGSNEF 196
L LYL + L + +P G L L+IL L NQL+ P + +N+L QLE L+L N+
Sbjct: 622 LQLLYLTNNLLTDQCIPVLVGHL-HLRILHLANNQLQTFPASKLNKLEQLEELNLSGNKL 680
Query: 197 TEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQ 256
+P + L +N ++ P + L Q+ ++D+S N++ + + LQ
Sbjct: 681 KTIPTTIANCKRLHTLVAHSNNISIFPEIL-QLPQIQFVDLSCNDLTEILIPEALPATLQ 739
Query: 257 DLLLSSNSLQQLP-ETIGSLKNITTLKIDENQL 288
DL L+ N+ L +T+ +ITTLKID+ L
Sbjct: 740 DLDLTGNTNLVLEHKTLDIFSHITTLKIDQKPL 772
Score = 85.1 bits (209), Expect = 4e-16
Identities = 81/323 (25%), Positives = 143/323 (44%), Gaps = 43/323 (13%)
Query: 117 LTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEF-LPANFGRLTK---LQILELRENQ 172
++ V+ S + ++P+ ++T L L F++ P L K L+ L L N+
Sbjct: 251 ISTVDLSCYSLEEVPEHLFYSQDITYLNLRHNFMQLERPGGLDTLYKFSQLKGLNLSHNK 310
Query: 173 LKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQL 232
L + P + ++ L L+L N F ++P + L L+ +D N LT +P +G+L+QL
Sbjct: 311 LGLFPILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEELGNLQQL 370
Query: 233 TYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLP----------------------- 269
+ L +S NN + E L ++++ N L+ L
Sbjct: 371 SSLGISFNNFSQIPEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLKTM 430
Query: 270 --ETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTF 327
E + K+IT + + +N+L L + L S+E+L C N++ L S +LRT
Sbjct: 431 VIENLEGNKHITHVDLRDNRLTDL--DLSSLCSLEQLHCGRNQLRELTLS---GFSLRTL 485
Query: 328 AADHNYLQQL----PPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNL 383
A N L + P + +T L L N LE +P+ + +K++V+++S N L +
Sbjct: 486 YASSNRLTAVNVYPVPSL-----LTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEV 540
Query: 384 PFSFTKLQQLTAMWLSDNQSKPL 406
P L + L N + L
Sbjct: 541 PVRILSSLSLRKLMLGHNHVQNL 563
Score = 72.8 bits (177), Expect = 2e-12
Identities = 73/295 (24%), Positives = 141/295 (47%), Gaps = 41/295 (13%)
Query: 47 TLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPA-SIANLINLRELDVSKNGIQ 105
+LE+L+ NQ+ EL F+ ++L+ S N LT + + +L+ LD+S+N ++
Sbjct: 461 SLEQLHCGRNQLRELTLSGFSLRTLYASS---NRLTAVNVYPVPSLLTF--LDLSRNLLE 515
Query: 106 EFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQI 165
P+ K + +++ S N ++++P L+L +L L ++ LP + L++
Sbjct: 516 CVPDWACEAKKIEVLDVSYNLLTEVPVRILSSLSLRKLMLGHNHVQNLPTLVEHIP-LEV 574
Query: 166 LELRENQLKMLPKTM-NRLTQLERLDLGSNEFTEVPEVL---EQLSGLKEFWMDANRLT- 220
L+L+ N L LP T+ ++ L L+ +N +P E LS L+ ++ N LT
Sbjct: 575 LDLQHNALTRLPDTLFSKALNLRYLNASANSLESLPSACTGEESLSMLQLLYLTNNLLTD 634
Query: 221 -FIPGFIG-----------------------SLKQLTYLDVSKNNIEMVEEGISTCENLQ 256
IP +G L+QL L++S N ++ + I+ C+ L
Sbjct: 635 QCIPVLVGHLHLRILHLANNQLQTFPASKLNKLEQLEELNLSGNKLKTIPTTIANCKRLH 694
Query: 257 DLLLSSNSLQQLPETIGSLKNITTLKIDENQL--MYLPDSIGGLISVEELDCSFN 309
L+ SN++ PE + L I + + N L + +P+++ ++++LD + N
Sbjct: 695 TLVAHSNNISIFPEIL-QLPQIQFVDLSCNDLTEILIPEALPA--TLQDLDLTGN 746
>gi|197333692 leucine rich repeat containing 8 family, member B
[Homo sapiens]
Length = 803
Score = 123 bits (308), Expect = 1e-27
Identities = 103/355 (29%), Positives = 170/355 (47%), Gaps = 11/355 (3%)
Query: 49 EELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNG-IQEF 107
+++ L + LP +F + LSL LP++++ L+NL+EL V + + +
Sbjct: 420 DKIELHLFMLNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDH 479
Query: 108 PENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFL-EFLPA----NFGRLTK 162
P + L I+ + K+P L NL +LYL+ L E L F L
Sbjct: 480 PALAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKN 539
Query: 163 LQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEV--LEQLSGLKEFWMDANRLT 220
L+ L L+ + ++ + L L++L L NE +++ + L+++ LK + + L
Sbjct: 540 LRTLYLKSSLSRIPQVVTDLLPSLQKLSL-DNEGSKLVVLNNLKKMVNLKSLELISCDLE 598
Query: 221 FIPGFIGSLKQLTYLDVSKNNIEMVEEGIST--CENLQDLLLSSNSLQQLPETIGSLKNI 278
IP I SL L LD+ +NN++ VEE IS +NL L L N++ +P IG+L N+
Sbjct: 599 RIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNL 658
Query: 279 TTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLP 338
L +D N + LP + + LD S+N + +P I L+NL+ FA +N ++ LP
Sbjct: 659 EQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLP 718
Query: 339 PEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQL 393
+ K + L L N L L +G++ L + L N L+ LP Q L
Sbjct: 719 DGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSL 773
Score = 108 bits (271), Expect = 3e-23
Identities = 90/294 (30%), Positives = 141/294 (47%), Gaps = 17/294 (5%)
Query: 21 EETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQ--------SLH 72
EE + L + ++P+ +F K L+ELYL LP+QL Q +L
Sbjct: 486 EENLKILRLKFTEMGKIPRWVFHL-KNLKELYLSGCV---LPEQLSTMQLEGFQDLKNLR 541
Query: 73 KLSLPDNDLTTLPASIANLI-NLRELDVSKNGIQEFP-ENIKNCKVLTIVEASVNPISKL 130
L L + L+ +P + +L+ +L++L + G + N+K L +E + ++
Sbjct: 542 TLYLKSS-LSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERI 600
Query: 131 PDGFSQLLNLTQLYLNDAFLEFLPA--NFGRLTKLQILELRENQLKMLPKTMNRLTQLER 188
P L NL +L L + L+ + +F L L L+L N + +P + L+ LE+
Sbjct: 601 PHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQ 660
Query: 189 LDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEG 248
L L N +P L + L + N LTFIP I L L Y V+ NNIEM+ +G
Sbjct: 661 LSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDG 720
Query: 249 ISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVE 302
+ C+ LQ LLL NSL L +G L N+T L++ N L LP + G S++
Sbjct: 721 LFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLK 774
Score = 99.8 bits (247), Expect = 2e-20
Identities = 86/346 (24%), Positives = 158/346 (45%), Gaps = 13/346 (3%)
Query: 108 PENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYL-NDAFLEFLPANFGRLTKLQIL 166
P+N+ + ++ + P KLP SQL+NL +L + + + + PA L+IL
Sbjct: 433 PDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEENLKIL 492
Query: 167 ELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLE-----QLSGLKEFWMDANRLTF 221
L+ ++ +P+ + L L+ L L E ++ L L+ ++ ++ L+
Sbjct: 493 RLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSS-LSR 551
Query: 222 IPGFIGSL-KQLTYLDVSKNNIEMVE-EGISTCENLQDLLLSSNSLQQLPETIGSLKNIT 279
IP + L L L + ++V + NL+ L L S L+++P +I SL N+
Sbjct: 552 IPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNLH 611
Query: 280 TLKIDENQLMYLPDSIGGLISVEELDCS---FNEVEALPSSIGQLTNLRTFAADHNYLQQ 336
L + EN L + + I ++ L C N + +P+ IG L+NL + DHN ++
Sbjct: 612 ELDLRENNLKTVEEIIS-FQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIEN 670
Query: 337 LPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAM 396
LP ++ + L L N L +PEE+ + L+ +++N ++ LP + ++L +
Sbjct: 671 LPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCL 730
Query: 397 WLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQPRTEDVMFISDN 442
L N L P E + T ++ NY+ P E + N
Sbjct: 731 LLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRN 776
Score = 70.1 bits (170), Expect = 1e-11
Identities = 55/167 (32%), Positives = 72/167 (43%), Gaps = 24/167 (14%)
Query: 22 ETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDL 81
+ ++ L H ++ +P +I LE+L LD N IE LP QLF C LH L L N L
Sbjct: 633 QNLSCLKLWHNNIAYIPAQIGALSN-LEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHL 691
Query: 82 TTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLT 141
T +P I L NL+ V+ N I+ LPDG Q L
Sbjct: 692 TFIPEEIQYLSNLQYFAVTNNNIE-----------------------MLPDGLFQCKKLQ 728
Query: 142 QLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLER 188
L L L L + G L+ L LEL N L+ LP + L+R
Sbjct: 729 CLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKR 775
>gi|21245134 leucine rich repeat containing 8 family, member B [Homo
sapiens]
Length = 803
Score = 123 bits (308), Expect = 1e-27
Identities = 103/355 (29%), Positives = 170/355 (47%), Gaps = 11/355 (3%)
Query: 49 EELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNG-IQEF 107
+++ L + LP +F + LSL LP++++ L+NL+EL V + + +
Sbjct: 420 DKIELHLFMLNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDH 479
Query: 108 PENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFL-EFLPA----NFGRLTK 162
P + L I+ + K+P L NL +LYL+ L E L F L
Sbjct: 480 PALAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKN 539
Query: 163 LQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEV--LEQLSGLKEFWMDANRLT 220
L+ L L+ + ++ + L L++L L NE +++ + L+++ LK + + L
Sbjct: 540 LRTLYLKSSLSRIPQVVTDLLPSLQKLSL-DNEGSKLVVLNNLKKMVNLKSLELISCDLE 598
Query: 221 FIPGFIGSLKQLTYLDVSKNNIEMVEEGIST--CENLQDLLLSSNSLQQLPETIGSLKNI 278
IP I SL L LD+ +NN++ VEE IS +NL L L N++ +P IG+L N+
Sbjct: 599 RIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNL 658
Query: 279 TTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLP 338
L +D N + LP + + LD S+N + +P I L+NL+ FA +N ++ LP
Sbjct: 659 EQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLP 718
Query: 339 PEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQL 393
+ K + L L N L L +G++ L + L N L+ LP Q L
Sbjct: 719 DGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSL 773
Score = 108 bits (271), Expect = 3e-23
Identities = 90/294 (30%), Positives = 141/294 (47%), Gaps = 17/294 (5%)
Query: 21 EETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQ--------SLH 72
EE + L + ++P+ +F K L+ELYL LP+QL Q +L
Sbjct: 486 EENLKILRLKFTEMGKIPRWVFHL-KNLKELYLSGCV---LPEQLSTMQLEGFQDLKNLR 541
Query: 73 KLSLPDNDLTTLPASIANLI-NLRELDVSKNGIQEFP-ENIKNCKVLTIVEASVNPISKL 130
L L + L+ +P + +L+ +L++L + G + N+K L +E + ++
Sbjct: 542 TLYLKSS-LSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERI 600
Query: 131 PDGFSQLLNLTQLYLNDAFLEFLPA--NFGRLTKLQILELRENQLKMLPKTMNRLTQLER 188
P L NL +L L + L+ + +F L L L+L N + +P + L+ LE+
Sbjct: 601 PHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQ 660
Query: 189 LDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEG 248
L L N +P L + L + N LTFIP I L L Y V+ NNIEM+ +G
Sbjct: 661 LSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDG 720
Query: 249 ISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVE 302
+ C+ LQ LLL NSL L +G L N+T L++ N L LP + G S++
Sbjct: 721 LFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLK 774
Score = 99.8 bits (247), Expect = 2e-20
Identities = 86/346 (24%), Positives = 158/346 (45%), Gaps = 13/346 (3%)
Query: 108 PENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYL-NDAFLEFLPANFGRLTKLQIL 166
P+N+ + ++ + P KLP SQL+NL +L + + + + PA L+IL
Sbjct: 433 PDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEENLKIL 492
Query: 167 ELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLE-----QLSGLKEFWMDANRLTF 221
L+ ++ +P+ + L L+ L L E ++ L L+ ++ ++ L+
Sbjct: 493 RLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSS-LSR 551
Query: 222 IPGFIGSL-KQLTYLDVSKNNIEMVE-EGISTCENLQDLLLSSNSLQQLPETIGSLKNIT 279
IP + L L L + ++V + NL+ L L S L+++P +I SL N+
Sbjct: 552 IPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNLH 611
Query: 280 TLKIDENQLMYLPDSIGGLISVEELDCS---FNEVEALPSSIGQLTNLRTFAADHNYLQQ 336
L + EN L + + I ++ L C N + +P+ IG L+NL + DHN ++
Sbjct: 612 ELDLRENNLKTVEEIIS-FQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIEN 670
Query: 337 LPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAM 396
LP ++ + L L N L +PEE+ + L+ +++N ++ LP + ++L +
Sbjct: 671 LPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCL 730
Query: 397 WLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQPRTEDVMFISDN 442
L N L P E + T ++ NY+ P E + N
Sbjct: 731 LLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRN 776
Score = 70.1 bits (170), Expect = 1e-11
Identities = 55/167 (32%), Positives = 72/167 (43%), Gaps = 24/167 (14%)
Query: 22 ETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDL 81
+ ++ L H ++ +P +I LE+L LD N IE LP QLF C LH L L N L
Sbjct: 633 QNLSCLKLWHNNIAYIPAQIGALSN-LEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHL 691
Query: 82 TTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLT 141
T +P I L NL+ V+ N I+ LPDG Q L
Sbjct: 692 TFIPEEIQYLSNLQYFAVTNNNIE-----------------------MLPDGLFQCKKLQ 728
Query: 142 QLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLER 188
L L L L + G L+ L LEL N L+ LP + L+R
Sbjct: 729 CLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKR 775
>gi|40217803 leucine rich repeat containing 8 family, member E [Homo
sapiens]
Length = 796
Score = 120 bits (302), Expect = 7e-27
Identities = 98/353 (27%), Positives = 165/353 (46%), Gaps = 28/353 (7%)
Query: 61 LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQ-EFPENIKNCKVLTI 119
LP +F + L L T P ++ L++L+EL + + + F + L +
Sbjct: 429 LPDTVFELSEVESLRLEAICDITFPPGLSQLVHLQELSLLHSPARLPFSLQVFLRDHLKV 488
Query: 120 VEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPA-----NFGRLTKLQILELRENQLK 174
+ + ++P L L +L+L F + L + L +L++L LR N K
Sbjct: 489 MRVKCEELREVPLWVFGLRGLEELHLEGLFPQELARAATLESLRELKQLKVLSLRSNAGK 548
Query: 175 MLPKTMNRLTQLERLDLGSNEFTEVP-EVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLT 233
+ + L+RL L ++ V L++L+ L+E + A L IP + SL L
Sbjct: 549 VPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAALRELELVACGLERIPHAVFSLGALQ 608
Query: 234 YLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPD 293
LD+ N++ +EE +S + + TL++ NQ+ Y+P+
Sbjct: 609 ELDLKDNHLRSIEEILS---------------------FQHCRKLVTLRLWHNQIAYVPE 647
Query: 294 SIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLH 353
+ L S+E+L S+N++E LPS +G + LR HN L LPPE+G +N+ L L
Sbjct: 648 HVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALS 707
Query: 354 SNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPL 406
N LE LPEE+ +KL+ + L DN+L L L+ L+ + L N+ + L
Sbjct: 708 YNALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEAL 760
Score = 70.1 bits (170), Expect = 1e-11
Identities = 51/155 (32%), Positives = 76/155 (49%), Gaps = 2/155 (1%)
Query: 39 KEIFTFE--KTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRE 96
+EI +F+ + L L L NQI +P+ + +SL +L L N L TLP+ + LR
Sbjct: 621 EEILSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRL 680
Query: 97 LDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPAN 156
LDVS NG+ P + + L + S N + LP+ L L L D L L +
Sbjct: 681 LDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLSPH 740
Query: 157 FGRLTKLQILELRENQLKMLPKTMNRLTQLERLDL 191
G L L LEL+ N+L+ LP+ + L++ L
Sbjct: 741 VGALRALSRLELKGNRLEALPEELGNCGGLKKAGL 775
Score = 55.1 bits (131), Expect = 5e-07
Identities = 71/299 (23%), Positives = 119/299 (39%), Gaps = 61/299 (20%)
Query: 166 LELRENQLKMLPKTMNRLTQLERLDLGS-------------------------------- 193
LEL L LP T+ L+++E L L +
Sbjct: 419 LELALCMLPGLPDTVFELSEVESLRLEAICDITFPPGLSQLVHLQELSLLHSPARLPFSL 478
Query: 194 ---------------NEFTEVPEVLEQLSGLKE------FWMDANRLTFIPGFIGSLKQL 232
E EVP + L GL+E F + R + + LKQL
Sbjct: 479 QVFLRDHLKVMRVKCEELREVPLWVFGLRGLEELHLEGLFPQELARAATLES-LRELKQL 537
Query: 233 TYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLK---IDENQLM 289
L + N ++ +LQ L L ++ + + + SLK + L+ + L
Sbjct: 538 KVLSLRSNAGKVPASVTDVAGHLQRLSLHNDGARLV--ALNSLKKLAALRELELVACGLE 595
Query: 290 YLPDSIGGLISVEELDCSFNEVEALPS--SIGQLTNLRTFAADHNYLQQLPPEIGSWKNI 347
+P ++ L +++ELD N + ++ S L T HN + +P + +++
Sbjct: 596 RIPHAVFSLGALQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSL 655
Query: 348 TVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPL 406
L+L NKLETLP ++G L+++++S N L +LP LQ L + LS N + L
Sbjct: 656 EQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEAL 714
>gi|62241040 leucine rich repeat containing 8 family, member A [Homo
sapiens]
Length = 810
Score = 115 bits (287), Expect = 4e-25
Identities = 101/349 (28%), Positives = 168/349 (48%), Gaps = 17/349 (4%)
Query: 49 EELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQ-EF 107
++L L + +P +F+ L L L T+P SIA L L+EL + + E
Sbjct: 426 DKLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEA 485
Query: 108 PENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYL-------NDAFLEFLPANFGRL 160
P + L + I ++P L L +L+L N+ ++ L
Sbjct: 486 PALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVI--DGLREL 543
Query: 161 TKLQILELRENQLKMLPKTMNRL-TQLERLDLGSNEFTE--VPEVLEQLSGLKEFWMDAN 217
+L++L L+ N L LP+ + + L++L + +NE T+ V L++++ L E +
Sbjct: 544 KRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSI-NNEGTKLIVLNSLKKMANLTELELIRC 601
Query: 218 RLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGIST--CENLQDLLLSSNSLQQLPETIGSL 275
L IP I SL L +D+ NN++ +EE IS L L L N + +P IG+L
Sbjct: 602 DLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNL 661
Query: 276 KNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQ 335
N+ L ++ N++ +P + + LD S N + LP+ IG L NL+ A N ++
Sbjct: 662 TNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIE 721
Query: 336 QLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLP 384
LPPE+ + + L L +N L++LP +G++ L I L NRL+ LP
Sbjct: 722 TLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLP 770
Score = 110 bits (276), Expect = 7e-24
Identities = 88/300 (29%), Positives = 147/300 (49%), Gaps = 19/300 (6%)
Query: 22 ETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLF-----NCQSLHKLSL 76
E + L ++++P I++ KTLEEL+L N E + + + L L L
Sbjct: 493 ENLRALHIKFTDIKEIPLWIYSL-KTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRL 551
Query: 77 PDNDLTTLPASIANL-INLRELDVSKNGIQEFPEN-IKNCKVLTIVEASVNPISKLPDGF 134
N L+ LP + ++ ++L++L ++ G + N +K LT +E + ++P
Sbjct: 552 KSN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSI 610
Query: 135 SQLLNLTQLYLNDAFLEFLPA--NFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLG 192
L NL ++ L D L+ + +F L +L L+L N + +P + LT LERL L
Sbjct: 611 FSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLN 670
Query: 193 SNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTC 252
N+ ++P L L+ + N LTF+P IG L+ L L ++ N IE + + C
Sbjct: 671 RNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQC 730
Query: 253 ENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIG--------GLISVEEL 304
L+ L L +N LQ LP +G L N+T +++ N+L LP +G GL+ E+L
Sbjct: 731 RKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDL 790
Score = 89.4 bits (220), Expect = 2e-17
Identities = 94/327 (28%), Positives = 149/327 (45%), Gaps = 61/327 (18%)
Query: 140 LTQLYLNDAFLEFLPANFGRLTK--LQILELRENQLKMLPKTMNRLTQLERLDLGSNEFT 197
L QL LN+ + L RLTK LEL L +P T+ L +LE L L
Sbjct: 402 LRQLNLNNEWT--LDKLRQRLTKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLELIPDV 459
Query: 198 EVPEVLEQLSGLKEFWM-------DANRLTF-----------------IPGFIGSLKQLT 233
+P + QL+GLKE W+ +A L F IP +I SLK L
Sbjct: 460 TIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLE 519
Query: 234 YLDVS-----KNNIEMVEEGISTCENLQDLLLSSNSLQQLPETI---------------- 272
L ++ +NN +V +G+ + L+ L L SN L +LP+ +
Sbjct: 520 ELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEG 578
Query: 273 ------GSLK---NITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIG--QL 321
SLK N+T L++ L +P SI L +++E+D N ++ + I L
Sbjct: 579 TKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHL 638
Query: 322 TNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLK 381
L +N++ +P +IG+ N+ L+L+ NK+E +P ++ +KL+ ++LS N L
Sbjct: 639 HRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLT 698
Query: 382 NLPFSFTKLQQLTAMWLSDNQSKPLIP 408
LP LQ L + ++ N+ + L P
Sbjct: 699 FLPADIGLLQNLQNLAITANRIETLPP 725
Score = 88.6 bits (218), Expect = 4e-17
Identities = 58/157 (36%), Positives = 80/157 (50%), Gaps = 5/157 (3%)
Query: 23 TVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLT 82
T L Y+H + +P +I LE LYL+ N+IE++P QLF C+ L L L N+LT
Sbjct: 642 TCLKLWYNH--IAYIPIQIGNLTN-LERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLT 698
Query: 83 TLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQ 142
LPA I L NL+ L ++ N I+ P + C+ L + N + LP +L NLTQ
Sbjct: 699 FLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQ 758
Query: 143 LYLNDAFLEFLPANFGR--LTKLQILELRENQLKMLP 177
+ L LE LP G L K L + E+ LP
Sbjct: 759 IELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLP 795
>gi|187829877 leucine rich repeat containing 8 family, member A
[Homo sapiens]
Length = 810
Score = 115 bits (287), Expect = 4e-25
Identities = 101/349 (28%), Positives = 168/349 (48%), Gaps = 17/349 (4%)
Query: 49 EELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQ-EF 107
++L L + +P +F+ L L L T+P SIA L L+EL + + E
Sbjct: 426 DKLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEA 485
Query: 108 PENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYL-------NDAFLEFLPANFGRL 160
P + L + I ++P L L +L+L N+ ++ L
Sbjct: 486 PALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVI--DGLREL 543
Query: 161 TKLQILELRENQLKMLPKTMNRL-TQLERLDLGSNEFTE--VPEVLEQLSGLKEFWMDAN 217
+L++L L+ N L LP+ + + L++L + +NE T+ V L++++ L E +
Sbjct: 544 KRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSI-NNEGTKLIVLNSLKKMANLTELELIRC 601
Query: 218 RLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGIST--CENLQDLLLSSNSLQQLPETIGSL 275
L IP I SL L +D+ NN++ +EE IS L L L N + +P IG+L
Sbjct: 602 DLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNL 661
Query: 276 KNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQ 335
N+ L ++ N++ +P + + LD S N + LP+ IG L NL+ A N ++
Sbjct: 662 TNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIE 721
Query: 336 QLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLP 384
LPPE+ + + L L +N L++LP +G++ L I L NRL+ LP
Sbjct: 722 TLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLP 770
Score = 110 bits (276), Expect = 7e-24
Identities = 88/300 (29%), Positives = 147/300 (49%), Gaps = 19/300 (6%)
Query: 22 ETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLF-----NCQSLHKLSL 76
E + L ++++P I++ KTLEEL+L N E + + + L L L
Sbjct: 493 ENLRALHIKFTDIKEIPLWIYSL-KTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRL 551
Query: 77 PDNDLTTLPASIANL-INLRELDVSKNGIQEFPEN-IKNCKVLTIVEASVNPISKLPDGF 134
N L+ LP + ++ ++L++L ++ G + N +K LT +E + ++P
Sbjct: 552 KSN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSI 610
Query: 135 SQLLNLTQLYLNDAFLEFLPA--NFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLG 192
L NL ++ L D L+ + +F L +L L+L N + +P + LT LERL L
Sbjct: 611 FSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLN 670
Query: 193 SNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTC 252
N+ ++P L L+ + N LTF+P IG L+ L L ++ N IE + + C
Sbjct: 671 RNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQC 730
Query: 253 ENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIG--------GLISVEEL 304
L+ L L +N LQ LP +G L N+T +++ N+L LP +G GL+ E+L
Sbjct: 731 RKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDL 790
Score = 89.4 bits (220), Expect = 2e-17
Identities = 94/327 (28%), Positives = 149/327 (45%), Gaps = 61/327 (18%)
Query: 140 LTQLYLNDAFLEFLPANFGRLTK--LQILELRENQLKMLPKTMNRLTQLERLDLGSNEFT 197
L QL LN+ + L RLTK LEL L +P T+ L +LE L L
Sbjct: 402 LRQLNLNNEWT--LDKLRQRLTKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLELIPDV 459
Query: 198 EVPEVLEQLSGLKEFWM-------DANRLTF-----------------IPGFIGSLKQLT 233
+P + QL+GLKE W+ +A L F IP +I SLK L
Sbjct: 460 TIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLE 519
Query: 234 YLDVS-----KNNIEMVEEGISTCENLQDLLLSSNSLQQLPETI---------------- 272
L ++ +NN +V +G+ + L+ L L SN L +LP+ +
Sbjct: 520 ELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEG 578
Query: 273 ------GSLK---NITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIG--QL 321
SLK N+T L++ L +P SI L +++E+D N ++ + I L
Sbjct: 579 TKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHL 638
Query: 322 TNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLK 381
L +N++ +P +IG+ N+ L+L+ NK+E +P ++ +KL+ ++LS N L
Sbjct: 639 HRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLT 698
Query: 382 NLPFSFTKLQQLTAMWLSDNQSKPLIP 408
LP LQ L + ++ N+ + L P
Sbjct: 699 FLPADIGLLQNLQNLAITANRIETLPP 725
Score = 88.6 bits (218), Expect = 4e-17
Identities = 58/157 (36%), Positives = 80/157 (50%), Gaps = 5/157 (3%)
Query: 23 TVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLT 82
T L Y+H + +P +I LE LYL+ N+IE++P QLF C+ L L L N+LT
Sbjct: 642 TCLKLWYNH--IAYIPIQIGNLTN-LERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLT 698
Query: 83 TLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQ 142
LPA I L NL+ L ++ N I+ P + C+ L + N + LP +L NLTQ
Sbjct: 699 FLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQ 758
Query: 143 LYLNDAFLEFLPANFGR--LTKLQILELRENQLKMLP 177
+ L LE LP G L K L + E+ LP
Sbjct: 759 IELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLP 795
>gi|187829871 leucine rich repeat containing 8 family, member A
[Homo sapiens]
Length = 810
Score = 115 bits (287), Expect = 4e-25
Identities = 101/349 (28%), Positives = 168/349 (48%), Gaps = 17/349 (4%)
Query: 49 EELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQ-EF 107
++L L + +P +F+ L L L T+P SIA L L+EL + + E
Sbjct: 426 DKLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEA 485
Query: 108 PENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYL-------NDAFLEFLPANFGRL 160
P + L + I ++P L L +L+L N+ ++ L
Sbjct: 486 PALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVI--DGLREL 543
Query: 161 TKLQILELRENQLKMLPKTMNRL-TQLERLDLGSNEFTE--VPEVLEQLSGLKEFWMDAN 217
+L++L L+ N L LP+ + + L++L + +NE T+ V L++++ L E +
Sbjct: 544 KRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSI-NNEGTKLIVLNSLKKMANLTELELIRC 601
Query: 218 RLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGIST--CENLQDLLLSSNSLQQLPETIGSL 275
L IP I SL L +D+ NN++ +EE IS L L L N + +P IG+L
Sbjct: 602 DLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNL 661
Query: 276 KNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQ 335
N+ L ++ N++ +P + + LD S N + LP+ IG L NL+ A N ++
Sbjct: 662 TNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIE 721
Query: 336 QLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLP 384
LPPE+ + + L L +N L++LP +G++ L I L NRL+ LP
Sbjct: 722 TLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLP 770
Score = 110 bits (276), Expect = 7e-24
Identities = 88/300 (29%), Positives = 147/300 (49%), Gaps = 19/300 (6%)
Query: 22 ETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLF-----NCQSLHKLSL 76
E + L ++++P I++ KTLEEL+L N E + + + L L L
Sbjct: 493 ENLRALHIKFTDIKEIPLWIYSL-KTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRL 551
Query: 77 PDNDLTTLPASIANL-INLRELDVSKNGIQEFPEN-IKNCKVLTIVEASVNPISKLPDGF 134
N L+ LP + ++ ++L++L ++ G + N +K LT +E + ++P
Sbjct: 552 KSN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSI 610
Query: 135 SQLLNLTQLYLNDAFLEFLPA--NFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLG 192
L NL ++ L D L+ + +F L +L L+L N + +P + LT LERL L
Sbjct: 611 FSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLN 670
Query: 193 SNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTC 252
N+ ++P L L+ + N LTF+P IG L+ L L ++ N IE + + C
Sbjct: 671 RNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQC 730
Query: 253 ENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIG--------GLISVEEL 304
L+ L L +N LQ LP +G L N+T +++ N+L LP +G GL+ E+L
Sbjct: 731 RKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDL 790
Score = 89.4 bits (220), Expect = 2e-17
Identities = 94/327 (28%), Positives = 149/327 (45%), Gaps = 61/327 (18%)
Query: 140 LTQLYLNDAFLEFLPANFGRLTK--LQILELRENQLKMLPKTMNRLTQLERLDLGSNEFT 197
L QL LN+ + L RLTK LEL L +P T+ L +LE L L
Sbjct: 402 LRQLNLNNEWT--LDKLRQRLTKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLELIPDV 459
Query: 198 EVPEVLEQLSGLKEFWM-------DANRLTF-----------------IPGFIGSLKQLT 233
+P + QL+GLKE W+ +A L F IP +I SLK L
Sbjct: 460 TIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLE 519
Query: 234 YLDVS-----KNNIEMVEEGISTCENLQDLLLSSNSLQQLPETI---------------- 272
L ++ +NN +V +G+ + L+ L L SN L +LP+ +
Sbjct: 520 ELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEG 578
Query: 273 ------GSLK---NITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIG--QL 321
SLK N+T L++ L +P SI L +++E+D N ++ + I L
Sbjct: 579 TKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHL 638
Query: 322 TNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLK 381
L +N++ +P +IG+ N+ L+L+ NK+E +P ++ +KL+ ++LS N L
Sbjct: 639 HRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLT 698
Query: 382 NLPFSFTKLQQLTAMWLSDNQSKPLIP 408
LP LQ L + ++ N+ + L P
Sbjct: 699 FLPADIGLLQNLQNLAITANRIETLPP 725
Score = 88.6 bits (218), Expect = 4e-17
Identities = 58/157 (36%), Positives = 80/157 (50%), Gaps = 5/157 (3%)
Query: 23 TVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLT 82
T L Y+H + +P +I LE LYL+ N+IE++P QLF C+ L L L N+LT
Sbjct: 642 TCLKLWYNH--IAYIPIQIGNLTN-LERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLT 698
Query: 83 TLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQ 142
LPA I L NL+ L ++ N I+ P + C+ L + N + LP +L NLTQ
Sbjct: 699 FLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQ 758
Query: 143 LYLNDAFLEFLPANFGR--LTKLQILELRENQLKMLP 177
+ L LE LP G L K L + E+ LP
Sbjct: 759 IELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLP 795
>gi|21389431 leucine rich repeat containing 39 [Homo sapiens]
Length = 335
Score = 114 bits (284), Expect = 8e-25
Identities = 68/218 (31%), Positives = 117/218 (53%), Gaps = 1/218 (0%)
Query: 165 ILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPG 224
IL++ + + K LP ++ +L QL+ L ++PE + + L + N ++ IP
Sbjct: 64 ILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPP 123
Query: 225 FIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSN-SLQQLPETIGSLKNITTLKI 283
IG L +L L +S N I+ V + +S C +L+ L L+ N + LP+ + +L +T L +
Sbjct: 124 GIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDL 183
Query: 284 DENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGS 343
N +P ++ + ++E LD N++E LP +I ++ NL T N + LP I +
Sbjct: 184 SMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISN 243
Query: 344 WKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLK 381
KN+ L L +NKL+ +P M +M L+ +N DN LK
Sbjct: 244 MKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLK 281
Score = 112 bits (281), Expect = 2e-24
Identities = 66/234 (28%), Positives = 124/234 (52%), Gaps = 3/234 (1%)
Query: 189 LDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEG 248
L + E+ +P L +L+ L+E+ + L IP FIG + L LD+S+N I + G
Sbjct: 65 LKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPG 124
Query: 249 ISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQ-LMYLPDSIGGLISVEELDCS 307
I LQ+L+LS N ++ +P+ + + ++ L++ N+ + LP + L+ + LD S
Sbjct: 125 IGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLS 184
Query: 308 FNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDM 367
N+ +P ++ + L N L+QLP I +N+ L+L N++ LP+ + +M
Sbjct: 185 MNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNM 244
Query: 368 QKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDN--QSKPLIPLQKETDSETQK 419
+ L + LS+N+L+++P ++ L + DN + K +P + TD E ++
Sbjct: 245 KNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLKLKVSLPPSEGTDEEEER 298
Score = 92.0 bits (227), Expect = 3e-18
Identities = 73/265 (27%), Positives = 115/265 (43%), Gaps = 60/265 (22%)
Query: 46 KTLEELYLDANQIEE----------LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLR 95
KTL L NQ++E +P+ + Q+L L L N ++ +P I L L+
Sbjct: 73 KTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQ 132
Query: 96 ELDVSKNGIQEFPENIKNCKVLTIVEASVN-PISKLPDGFSQLLNLTQLYLNDAFLEFLP 154
EL +S N I+ P+ + NC L +E +VN I LP S LL LT L
Sbjct: 133 ELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHL----------- 181
Query: 155 ANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWM 214
+L N +P + + LE LD+GSN+ ++P+ +E++ L W+
Sbjct: 182 ------------DLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWL 229
Query: 215 DANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGS 274
N +T +P + IS +NL L+LS+N LQ +P +
Sbjct: 230 QRNEITCLP-----------------------QTISNMKNLGTLVLSNNKLQDIPVCMEE 266
Query: 275 LKNITTLKIDENQL---MYLPDSIG 296
+ N+ + +N L + LP S G
Sbjct: 267 MANLRFVNFRDNPLKLKVSLPPSEG 291
Score = 77.4 bits (189), Expect = 9e-14
Identities = 51/181 (28%), Positives = 86/181 (47%), Gaps = 25/181 (13%)
Query: 19 GEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPD 78
G + + LD S ++ ++P I + L+EL L N+I+ +PK+L NC SL KL L
Sbjct: 103 GRFQNLIVLDLSRNTISEIPPGIGLLTR-LQELILSYNKIKTVPKELSNCASLEKLELAV 161
Query: 79 N------------------------DLTTLPASIANLINLRELDVSKNGIQEFPENIKNC 114
N D TT+P ++ N+ L LD+ N +++ P+ I+
Sbjct: 162 NRDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERM 221
Query: 115 KVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLK 174
+ L + N I+ LP S + NL L L++ L+ +P + L+ + R+N LK
Sbjct: 222 QNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLK 281
Query: 175 M 175
+
Sbjct: 282 L 282
Score = 61.2 bits (147), Expect = 6e-09
Identities = 41/139 (29%), Positives = 70/139 (50%), Gaps = 1/139 (0%)
Query: 264 SLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTN 323
SL +L E + LKI++ + LP S+ L ++E + +P IG+ N
Sbjct: 48 SLTKLREKVTREDGRVILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQN 107
Query: 324 LRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNR-LKN 382
L N + ++PP IG + L L NK++T+P+E+ + L+ + L+ NR + +
Sbjct: 108 LIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICD 167
Query: 383 LPFSFTKLQQLTAMWLSDN 401
LP + L +LT + LS N
Sbjct: 168 LPQELSNLLKLTHLDLSMN 186
>gi|19923729 leucine rich repeat containing 8 family, member C [Homo
sapiens]
Length = 803
Score = 112 bits (280), Expect = 2e-24
Identities = 95/366 (25%), Positives = 170/366 (46%), Gaps = 30/366 (8%)
Query: 51 LYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPEN 110
L L + LP +F L L L +PA+IA L NL+EL + + ++
Sbjct: 426 LELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSAA 485
Query: 111 IKNCKV-LTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPAN-----FGRLTKLQ 164
+ K L ++ + + +LP L NL +LYL + + N L L+
Sbjct: 486 LSFLKENLKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRNVTLESLRDLKSLK 545
Query: 165 ILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEV--LEQLSGLKEFWMDANRLTFI 222
IL ++ N K+ ++ + L+++ + N+ T++ + L++++ L E + L I
Sbjct: 546 ILSIKSNVSKIPQAVVDVSSHLQKMCI-HNDGTKLVMLNNLKKMTNLTELELVHCDLERI 604
Query: 223 PGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLK 282
P + SL L LD+ +NN++ +EE +S L+ +T LK
Sbjct: 605 PHAVFSLLSLQELDLKENNLKSIEEIVS---------------------FQHLRKLTVLK 643
Query: 283 IDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIG 342
+ N + Y+P+ I L S+E L S N++E LPS + +R +N ++ +PPEIG
Sbjct: 644 LWHNSITYIPEHIKKLTSLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIG 703
Query: 343 SWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQ 402
+++ + NK+E+LP+E+ +KLK + + N L L L L+ + + N
Sbjct: 704 VLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNH 763
Query: 403 SKPLIP 408
+ L P
Sbjct: 764 FEILPP 769
Score = 111 bits (278), Expect = 4e-24
Identities = 82/292 (28%), Positives = 139/292 (47%), Gaps = 39/292 (13%)
Query: 69 QSLHKLSLPDNDLTTLPASIANLINLREL--------DVSKNGIQEFPENIKNCKVLTIV 120
++L LS+ +D+ LP + L NL EL D+S+N E ++K+ K+L+I
Sbjct: 491 ENLKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRNVTLESLRDLKSLKILSIK 550
Query: 121 EASVNPISKLP-------------------------DGFSQLLNLTQLYLNDAFLEFLPA 155
+ +SK+P + ++ NLT+L L LE +P
Sbjct: 551 ----SNVSKIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDLERIPH 606
Query: 156 NFGRLTKLQILELRENQLKMLPKTMN--RLTQLERLDLGSNEFTEVPEVLEQLSGLKEFW 213
L LQ L+L+EN LK + + ++ L +L L L N T +PE +++L+ L+
Sbjct: 607 AVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLS 666
Query: 214 MDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIG 273
N++ +P + ++ YLD+S N+I + I ++LQ ++ N ++ LP+ +
Sbjct: 667 FSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELY 726
Query: 274 SLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLR 325
K + TLKI +N L L IG L+ + LD N E LP +G L+
Sbjct: 727 FCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPELGDCRALK 778
Score = 66.2 bits (160), Expect = 2e-10
Identities = 47/166 (28%), Positives = 74/166 (44%), Gaps = 3/166 (1%)
Query: 24 VTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTT 83
+T L H S+ +P+ I +LE L N+IE LP LF C + L L ND+
Sbjct: 639 LTVLKLWHNSITYIPEHIKKLT-SLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRF 697
Query: 84 LPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQL 143
+P I L +L+ ++ N ++ P+ + CK L ++ N +S L LL L+ L
Sbjct: 698 IPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYL 757
Query: 144 YLNDAFLEFLPANFG--RLTKLQILELRENQLKMLPKTMNRLTQLE 187
+ E LP G R K L + + + LP + + E
Sbjct: 758 DVKGNHFEILPPELGDCRALKRAGLVVEDALFETLPSDVREQMKTE 803
Score = 63.5 bits (153), Expect = 1e-09
Identities = 50/192 (26%), Positives = 79/192 (41%), Gaps = 24/192 (12%)
Query: 24 VTTLDYSHCSLEQVPKEIFTFE------------KTLEE------------LYLDANQIE 59
+T L+ HC LE++P +F+ K++EE L L N I
Sbjct: 591 LTELELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSIT 650
Query: 60 ELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTI 119
+P+ + SL +LS N + LP+ + +R LD+S N I+ P I + L
Sbjct: 651 YIPEHIKKLTSLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQY 710
Query: 120 VEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKT 179
+ N + LPD L L + L L G L L L+++ N ++LP
Sbjct: 711 FSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPE 770
Query: 180 MNRLTQLERLDL 191
+ L+R L
Sbjct: 771 LGDCRALKRAGL 782
Score = 52.8 bits (125), Expect = 2e-06
Identities = 61/282 (21%), Positives = 126/282 (44%), Gaps = 42/282 (14%)
Query: 167 ELRENQLKML-------PKTMNRLTQLE---RLDLGSNEFTEVPEVLEQLSGLKEFWMDA 216
E+ EN+LK L P + + Q RL+L + +P+ + +++ L+ ++
Sbjct: 394 EVSENKLKQLNLNNEWTPDKLRQKLQTNAHNRLELPLIMLSGLPDTVFEITELQSLKLEI 453
Query: 217 NRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTC-ENLQDLLLSSNSLQQLPE----- 270
+ IP I L L L + + ++++ +S ENL+ L + + +++LP
Sbjct: 454 IKNVMIPATIAQLDNLQELSLHQCSVKIHSAALSFLKENLKVLSVKFDDMRELPPWMYGL 513
Query: 271 --------------------TIGSLKNITTLKI--DENQLMYLPDSIGGLISVEELDCSF 308
T+ SL+++ +LKI ++ + +P ++ + S + C
Sbjct: 514 RNLEELYLVGSLSHDISRNVTLESLRDLKSLKILSIKSNVSKIPQAVVDVSSHLQKMCIH 573
Query: 309 NEVEALP--SSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPE--EM 364
N+ L +++ ++TNL H L+++P + S ++ L L N L+++ E
Sbjct: 574 NDGTKLVMLNNLKKMTNLTELELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEIVSF 633
Query: 365 GDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPL 406
++KL V+ L N + +P KL L + S N+ + L
Sbjct: 634 QHLRKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHNKIEVL 675
>gi|61742786 leucine rich repeat and death domain containing protein
isoform 3 [Homo sapiens]
Length = 893
Score = 112 bits (279), Expect = 3e-24
Identities = 81/257 (31%), Positives = 130/257 (50%), Gaps = 24/257 (9%)
Query: 131 PDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLD 190
P G QLL+L L+ L F RL+ + +L E L LP++++ L L
Sbjct: 44 PGGCQQLLHLCV----QQPLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSL---- 95
Query: 191 LGSNEFTEVPEVLEQLSGLKEFWMDA---NRLTFIPGFIGSLKQLTYLDVSKNNIEMVEE 247
VL+ G + + A LT +P + L L +LD+S N++E +
Sbjct: 96 -----------VLK--GGQRRDTLGACLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPA 142
Query: 248 GISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCS 307
+ L LLLS N L +LPE +G+L +T L + N+L LP ++G L +++ LD S
Sbjct: 143 CVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLS 202
Query: 308 FNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDM 367
N ++ LP IG L +L N LQ LP + +++ +L LHSN L ++P ++ +
Sbjct: 203 QNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARL 262
Query: 368 QKLKVINLSDNRLKNLP 384
L ++L DN+L++LP
Sbjct: 263 PLLTRLDLRDNQLRDLP 279
Score = 90.1 bits (222), Expect = 1e-17
Identities = 55/169 (32%), Positives = 85/169 (50%)
Query: 173 LKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQL 232
L LP ++ L L LDL N +P + Q+ GL + N L+ +P +G+L L
Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
Query: 233 TYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLP 292
T+L V+ N ++ + + LQ L LS N L LP IG L ++ L + N+L LP
Sbjct: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
Query: 293 DSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEI 341
S+ GL S+ L N + ++P+ + +L L N L+ LPPE+
Sbjct: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
Score = 82.8 bits (203), Expect = 2e-15
Identities = 54/162 (33%), Positives = 81/162 (50%)
Query: 81 LTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNL 140
LT LPA ++ L +L LD+S N ++ P + + L + S N +S+LP+ L L
Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
Query: 141 TQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVP 200
T L + L+ LP G L+ LQ L+L +N L LP + L L L+L SN +P
Sbjct: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
Query: 201 EVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNI 242
L L L+ + +N L +P + L LT LD+ N +
Sbjct: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQL 275
Score = 80.5 bits (197), Expect = 1e-14
Identities = 58/204 (28%), Positives = 103/204 (50%), Gaps = 13/204 (6%)
Query: 213 WMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETI 272
++ NRL+ + + G +QL +L V + +++++ +D L +L QLP+++
Sbjct: 32 FLGGNRLS-LDLYPGGCQQLLHLCVQQP-LQLLQVEFLRLSTHEDPQLLEATLAQLPQSL 89
Query: 273 GSLKNITTLKIDENQ----------LMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLT 322
L+++ LK + + L LP + GL + LD SFN +E LP+ + Q+
Sbjct: 90 SCLRSLV-LKGGQRRDTLGACLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMR 148
Query: 323 NLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKN 382
L HN L +LP +G+ +T L + N+L+TLP +G + L+ ++LS N L
Sbjct: 149 GLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDT 208
Query: 383 LPFSFTKLQQLTAMWLSDNQSKPL 406
LP L L + L+ N+ + L
Sbjct: 209 LPPEIGGLGSLLELNLASNRLQSL 232
Score = 76.3 bits (186), Expect = 2e-13
Identities = 53/169 (31%), Positives = 83/169 (49%)
Query: 127 ISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQL 186
++ LP G S L +L L L+ LE LPA ++ L L L N L LP+ + L L
Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
Query: 187 ERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVE 246
L + N +P L LS L+ + N L +P IG L L L+++ N ++ +
Sbjct: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
Query: 247 EGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSI 295
++ +L+ L+L SN L +P + L +T L + +NQL LP +
Sbjct: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
Score = 73.2 bits (178), Expect = 2e-12
Identities = 54/166 (32%), Positives = 74/166 (44%)
Query: 58 IEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVL 117
+ LP L L L L N L TLPA + + L L +S N + E PE + L
Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
Query: 118 TIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLP 177
T + + N + LP L L +L L+ L+ LP G L L L L N+L+ LP
Sbjct: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
Query: 178 KTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIP 223
++ L L L L SN VP L +L L + N+L +P
Sbjct: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP 279
Score = 72.0 bits (175), Expect = 4e-12
Identities = 51/156 (32%), Positives = 74/156 (47%)
Query: 48 LEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEF 107
L L L N +E LP + + L L L N L+ LP ++ L L L V+ N +Q
Sbjct: 127 LAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTL 186
Query: 108 PENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILE 167
P + L ++ S N + LP L +L +L L L+ LPA+ L L++L
Sbjct: 187 PPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLV 246
Query: 168 LRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVL 203
L N L +P + RL L RLDL N+ ++P L
Sbjct: 247 LHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
Score = 52.8 bits (125), Expect = 2e-06
Identities = 35/113 (30%), Positives = 58/113 (51%), Gaps = 1/113 (0%)
Query: 19 GEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPD 78
G +T L +H L+ +P + TL+ L L N ++ LP ++ SL +L+L
Sbjct: 168 GALPALTFLTVTHNRLQTLPPALGALS-TLQRLDLSQNLLDTLPPEIGGLGSLLELNLAS 226
Query: 79 NDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLP 131
N L +LPAS+A L +LR L + N + P ++ +LT ++ N + LP
Sbjct: 227 NRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP 279
Score = 48.5 bits (114), Expect = 4e-05
Identities = 32/93 (34%), Positives = 48/93 (51%), Gaps = 1/93 (1%)
Query: 19 GEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPD 78
G T+ LD S L+ +P EI LE L L +N+++ LP L +SL L L
Sbjct: 191 GALSTLQRLDLSQNLLDTLPPEIGGLGSLLE-LNLASNRLQSLPASLAGLRSLRLLVLHS 249
Query: 79 NDLTTLPASIANLINLRELDVSKNGIQEFPENI 111
N L ++PA +A L L LD+ N +++ P +
Sbjct: 250 NLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
>gi|61742784 leucine rich repeat and death domain containing protein
isoform 1 [Homo sapiens]
Length = 910
Score = 112 bits (279), Expect = 3e-24
Identities = 81/257 (31%), Positives = 130/257 (50%), Gaps = 24/257 (9%)
Query: 131 PDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLD 190
P G QLL+L L+ L F RL+ + +L E L LP++++ L L
Sbjct: 44 PGGCQQLLHLCV----QQPLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSL---- 95
Query: 191 LGSNEFTEVPEVLEQLSGLKEFWMDA---NRLTFIPGFIGSLKQLTYLDVSKNNIEMVEE 247
VL+ G + + A LT +P + L L +LD+S N++E +
Sbjct: 96 -----------VLK--GGQRRDTLGACLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPA 142
Query: 248 GISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCS 307
+ L LLLS N L +LPE +G+L +T L + N+L LP ++G L +++ LD S
Sbjct: 143 CVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLS 202
Query: 308 FNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDM 367
N ++ LP IG L +L N LQ LP + +++ +L LHSN L ++P ++ +
Sbjct: 203 QNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARL 262
Query: 368 QKLKVINLSDNRLKNLP 384
L ++L DN+L++LP
Sbjct: 263 PLLTRLDLRDNQLRDLP 279
Score = 90.1 bits (222), Expect = 1e-17
Identities = 55/169 (32%), Positives = 85/169 (50%)
Query: 173 LKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQL 232
L LP ++ L L LDL N +P + Q+ GL + N L+ +P +G+L L
Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
Query: 233 TYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLP 292
T+L V+ N ++ + + LQ L LS N L LP IG L ++ L + N+L LP
Sbjct: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
Query: 293 DSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEI 341
S+ GL S+ L N + ++P+ + +L L N L+ LPPE+
Sbjct: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
Score = 82.8 bits (203), Expect = 2e-15
Identities = 54/162 (33%), Positives = 81/162 (50%)
Query: 81 LTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNL 140
LT LPA ++ L +L LD+S N ++ P + + L + S N +S+LP+ L L
Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
Query: 141 TQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVP 200
T L + L+ LP G L+ LQ L+L +N L LP + L L L+L SN +P
Sbjct: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
Query: 201 EVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNI 242
L L L+ + +N L +P + L LT LD+ N +
Sbjct: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQL 275
Score = 80.5 bits (197), Expect = 1e-14
Identities = 58/204 (28%), Positives = 103/204 (50%), Gaps = 13/204 (6%)
Query: 213 WMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETI 272
++ NRL+ + + G +QL +L V + +++++ +D L +L QLP+++
Sbjct: 32 FLGGNRLS-LDLYPGGCQQLLHLCVQQP-LQLLQVEFLRLSTHEDPQLLEATLAQLPQSL 89
Query: 273 GSLKNITTLKIDENQ----------LMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLT 322
L+++ LK + + L LP + GL + LD SFN +E LP+ + Q+
Sbjct: 90 SCLRSLV-LKGGQRRDTLGACLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMR 148
Query: 323 NLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKN 382
L HN L +LP +G+ +T L + N+L+TLP +G + L+ ++LS N L
Sbjct: 149 GLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDT 208
Query: 383 LPFSFTKLQQLTAMWLSDNQSKPL 406
LP L L + L+ N+ + L
Sbjct: 209 LPPEIGGLGSLLELNLASNRLQSL 232
Score = 76.3 bits (186), Expect = 2e-13
Identities = 53/169 (31%), Positives = 83/169 (49%)
Query: 127 ISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQL 186
++ LP G S L +L L L+ LE LPA ++ L L L N L LP+ + L L
Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
Query: 187 ERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVE 246
L + N +P L LS L+ + N L +P IG L L L+++ N ++ +
Sbjct: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
Query: 247 EGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSI 295
++ +L+ L+L SN L +P + L +T L + +NQL LP +
Sbjct: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
Score = 73.2 bits (178), Expect = 2e-12
Identities = 54/166 (32%), Positives = 74/166 (44%)
Query: 58 IEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVL 117
+ LP L L L L N L TLPA + + L L +S N + E PE + L
Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
Query: 118 TIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLP 177
T + + N + LP L L +L L+ L+ LP G L L L L N+L+ LP
Sbjct: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
Query: 178 KTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIP 223
++ L L L L SN VP L +L L + N+L +P
Sbjct: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP 279
Score = 72.0 bits (175), Expect = 4e-12
Identities = 51/156 (32%), Positives = 74/156 (47%)
Query: 48 LEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEF 107
L L L N +E LP + + L L L N L+ LP ++ L L L V+ N +Q
Sbjct: 127 LAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTL 186
Query: 108 PENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILE 167
P + L ++ S N + LP L +L +L L L+ LPA+ L L++L
Sbjct: 187 PPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLV 246
Query: 168 LRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVL 203
L N L +P + RL L RLDL N+ ++P L
Sbjct: 247 LHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
Score = 52.8 bits (125), Expect = 2e-06
Identities = 35/113 (30%), Positives = 58/113 (51%), Gaps = 1/113 (0%)
Query: 19 GEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPD 78
G +T L +H L+ +P + TL+ L L N ++ LP ++ SL +L+L
Sbjct: 168 GALPALTFLTVTHNRLQTLPPALGALS-TLQRLDLSQNLLDTLPPEIGGLGSLLELNLAS 226
Query: 79 NDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLP 131
N L +LPAS+A L +LR L + N + P ++ +LT ++ N + LP
Sbjct: 227 NRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP 279
Score = 48.5 bits (114), Expect = 4e-05
Identities = 32/93 (34%), Positives = 48/93 (51%), Gaps = 1/93 (1%)
Query: 19 GEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPD 78
G T+ LD S L+ +P EI LE L L +N+++ LP L +SL L L
Sbjct: 191 GALSTLQRLDLSQNLLDTLPPEIGGLGSLLE-LNLASNRLQSLPASLAGLRSLRLLVLHS 249
Query: 79 NDLTTLPASIANLINLRELDVSKNGIQEFPENI 111
N L ++PA +A L L LD+ N +++ P +
Sbjct: 250 NLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282
>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
sapiens]
Length = 587
Score = 111 bits (278), Expect = 4e-24
Identities = 113/404 (27%), Positives = 183/404 (45%), Gaps = 49/404 (12%)
Query: 66 FNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEF-PENIKNCKVLTIVEASV 124
+N SL L+ +L P N+ L L + KN + P +N L + +
Sbjct: 59 WNAMSLQILNTHITELNESP--FLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLAN 116
Query: 125 NPISKLPDGFSQLLNLTQLYL--NDAFLEFLPANFGRLTKLQILELRENQLKMLPK-TMN 181
N + LP G Q L+ + L ++ L+ PA+F + + L+ L+L N L+ +P +
Sbjct: 117 NKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFD 176
Query: 182 RLTQLERLDLGSNEFTEV-PEVLEQLSGLKEFWMDANRLTFIP-GFIGSLKQLTYLDVSK 239
L L +L+LG N T + P V + L L+ + NRLT IP G L L L + +
Sbjct: 177 HLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQ 236
Query: 240 NNIEMVEEGI-STCENLQDLLLSSNSLQQLPETI-------------------------G 273
N I ++ G+ NLQ L LS+N + QLP +I G
Sbjct: 237 NQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFG 296
Query: 274 SLKNITTLKIDENQLMYLPDSI-GGLISVEELDCSFNEVEAL-PSSIGQLTNLRTFAADH 331
+ N+ L + +N + LPD++ L ++ L S N++ + P + LT LR +
Sbjct: 297 PMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHT 356
Query: 332 NYLQQLPPEI-GSWKNITVLFLHSNKLETLPEEM-GDMQKLKVINLSDNRLKNLPFS-FT 388
N LQ L + N+ + L +N+L LP + ++ L I L +N+L+NLP F
Sbjct: 357 NALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFD 416
Query: 389 KLQQLTAMWLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQPR 432
L +L + L DN P + ++D + L N++ QPR
Sbjct: 417 HLGKLCELRLYDN------PWRCDSDI----LPLRNWLLLNQPR 450
Score = 110 bits (275), Expect = 9e-24
Identities = 98/342 (28%), Positives = 167/342 (48%), Gaps = 14/342 (4%)
Query: 51 LYLDANQIEELPKQLF-NCQSLHKLSLPDNDLTTLPASI-ANLINLRELDVSKNGIQEF- 107
L ++ N++ + F N SL LSL +N L LP + L +L L +S N + +
Sbjct: 88 LRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQ 147
Query: 108 PENIKNCKVLTIVEASVNPISKLPDG-FSQLLNLTQLYL-NDAFLEFLPANFGRLTKLQI 165
P + C L ++ N + +PDG F L+ LT+L L ++ P F L LQ+
Sbjct: 148 PAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQV 207
Query: 166 LELRENQLKMLPK-TMNRLTQLERLDLGSNEFTEV-PEVLEQLSGLKEFWMDANRLTFI- 222
L L EN+L +P T + L L+ L L N+ + P + L+ ++ N ++ +
Sbjct: 208 LRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLP 267
Query: 223 PGFIGSLKQLTYLDVSKNNIEMVEEGI-STCENLQDLLLSSNSLQQLPETI-GSLKNITT 280
P L QL L + N+++ + GI NL++L L N + LP+ + +L+ +
Sbjct: 268 PSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQV 327
Query: 281 LKIDENQLMYL-PDSIGGLISVEELDCSFNEVEALPSSI-GQLTNLRTFAADHNYLQQLP 338
L + NQ+ ++ P + GL + EL N ++ L ++ L NL+ + +N L+QLP
Sbjct: 328 LILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLP 387
Query: 339 PEI-GSWKNITVLFLHSNKLETLPEEMGD-MQKLKVINLSDN 378
I + + + L +N+LE LP + D + KL + L DN
Sbjct: 388 GNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDN 429
Score = 72.0 bits (175), Expect = 4e-12
Identities = 67/222 (30%), Positives = 99/222 (44%), Gaps = 28/222 (12%)
Query: 34 LEQVPKEIFTFEKTLEELYLDANQIEELPKQLF-NCQSLHKLSLPDNDLTTLPASI-ANL 91
L +P F L+EL L NQI L LF N +L +L L +N ++ LP SI L
Sbjct: 215 LTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQL 274
Query: 92 INLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLE 151
L L + N ++E I F + NL +L+L D +
Sbjct: 275 PQLNRLTLFGNSLKELSLGI----------------------FGPMPNLRELWLYDNHIS 312
Query: 152 FLPAN-FGRLTKLQILELRENQLKML-PKTMNRLTQLERLDLGSNEFTEVP-EVLEQLSG 208
LP N F L +LQ+L L NQ+ + P N LT+L L L +N ++ V L+
Sbjct: 313 SLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLAN 372
Query: 209 LKEFWMDANRLTFIPGFI-GSLKQLTYLDVSKNNIEMVEEGI 249
L+ + NRL +PG I ++ L + + N +E + GI
Sbjct: 373 LQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGI 414
Score = 52.4 bits (124), Expect = 3e-06
Identities = 44/148 (29%), Positives = 65/148 (43%), Gaps = 25/148 (16%)
Query: 33 SLEQVPKEIFTFEKTLEELYLDANQIEELPKQLF-NCQSLHKLSLPDNDLTTL-PASIAN 90
SL+++ IF L EL+L N I LP +F N + L L L N ++ + P +
Sbjct: 286 SLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNG 345
Query: 91 LINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFL 150
L LREL + N +Q+ N+ F L NL + L + L
Sbjct: 346 LTELRELSLHTNALQDLDGNV----------------------FRMLANLQNISLQNNRL 383
Query: 151 EFLPAN-FGRLTKLQILELRENQLKMLP 177
LP N F + L ++L+ NQL+ LP
Sbjct: 384 RQLPGNIFANVNGLMAIQLQNNQLENLP 411
>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
sapiens]
Length = 581
Score = 111 bits (278), Expect = 4e-24
Identities = 113/404 (27%), Positives = 183/404 (45%), Gaps = 49/404 (12%)
Query: 66 FNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEF-PENIKNCKVLTIVEASV 124
+N SL L+ +L P N+ L L + KN + P +N L + +
Sbjct: 53 WNAMSLQILNTHITELNESP--FLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLAN 110
Query: 125 NPISKLPDGFSQLLNLTQLYL--NDAFLEFLPANFGRLTKLQILELRENQLKMLPK-TMN 181
N + LP G Q L+ + L ++ L+ PA+F + + L+ L+L N L+ +P +
Sbjct: 111 NKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFD 170
Query: 182 RLTQLERLDLGSNEFTEV-PEVLEQLSGLKEFWMDANRLTFIP-GFIGSLKQLTYLDVSK 239
L L +L+LG N T + P V + L L+ + NRLT IP G L L L + +
Sbjct: 171 HLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQ 230
Query: 240 NNIEMVEEGI-STCENLQDLLLSSNSLQQLPETI-------------------------G 273
N I ++ G+ NLQ L LS+N + QLP +I G
Sbjct: 231 NQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFG 290
Query: 274 SLKNITTLKIDENQLMYLPDSI-GGLISVEELDCSFNEVEAL-PSSIGQLTNLRTFAADH 331
+ N+ L + +N + LPD++ L ++ L S N++ + P + LT LR +
Sbjct: 291 PMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHT 350
Query: 332 NYLQQLPPEI-GSWKNITVLFLHSNKLETLPEEM-GDMQKLKVINLSDNRLKNLPFS-FT 388
N LQ L + N+ + L +N+L LP + ++ L I L +N+L+NLP F
Sbjct: 351 NALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFD 410
Query: 389 KLQQLTAMWLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQPR 432
L +L + L DN P + ++D + L N++ QPR
Sbjct: 411 HLGKLCELRLYDN------PWRCDSDI----LPLRNWLLLNQPR 444
Score = 110 bits (275), Expect = 9e-24
Identities = 98/342 (28%), Positives = 167/342 (48%), Gaps = 14/342 (4%)
Query: 51 LYLDANQIEELPKQLF-NCQSLHKLSLPDNDLTTLPASI-ANLINLRELDVSKNGIQEF- 107
L ++ N++ + F N SL LSL +N L LP + L +L L +S N + +
Sbjct: 82 LRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQ 141
Query: 108 PENIKNCKVLTIVEASVNPISKLPDG-FSQLLNLTQLYL-NDAFLEFLPANFGRLTKLQI 165
P + C L ++ N + +PDG F L+ LT+L L ++ P F L LQ+
Sbjct: 142 PAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQV 201
Query: 166 LELRENQLKMLPK-TMNRLTQLERLDLGSNEFTEV-PEVLEQLSGLKEFWMDANRLTFI- 222
L L EN+L +P T + L L+ L L N+ + P + L+ ++ N ++ +
Sbjct: 202 LRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLP 261
Query: 223 PGFIGSLKQLTYLDVSKNNIEMVEEGI-STCENLQDLLLSSNSLQQLPETI-GSLKNITT 280
P L QL L + N+++ + GI NL++L L N + LP+ + +L+ +
Sbjct: 262 PSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQV 321
Query: 281 LKIDENQLMYL-PDSIGGLISVEELDCSFNEVEALPSSI-GQLTNLRTFAADHNYLQQLP 338
L + NQ+ ++ P + GL + EL N ++ L ++ L NL+ + +N L+QLP
Sbjct: 322 LILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLP 381
Query: 339 PEI-GSWKNITVLFLHSNKLETLPEEMGD-MQKLKVINLSDN 378
I + + + L +N+LE LP + D + KL + L DN
Sbjct: 382 GNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDN 423
Score = 72.0 bits (175), Expect = 4e-12
Identities = 67/222 (30%), Positives = 99/222 (44%), Gaps = 28/222 (12%)
Query: 34 LEQVPKEIFTFEKTLEELYLDANQIEELPKQLF-NCQSLHKLSLPDNDLTTLPASI-ANL 91
L +P F L+EL L NQI L LF N +L +L L +N ++ LP SI L
Sbjct: 209 LTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQL 268
Query: 92 INLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLE 151
L L + N ++E I F + NL +L+L D +
Sbjct: 269 PQLNRLTLFGNSLKELSLGI----------------------FGPMPNLRELWLYDNHIS 306
Query: 152 FLPAN-FGRLTKLQILELRENQLKML-PKTMNRLTQLERLDLGSNEFTEVP-EVLEQLSG 208
LP N F L +LQ+L L NQ+ + P N LT+L L L +N ++ V L+
Sbjct: 307 SLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLAN 366
Query: 209 LKEFWMDANRLTFIPGFI-GSLKQLTYLDVSKNNIEMVEEGI 249
L+ + NRL +PG I ++ L + + N +E + GI
Sbjct: 367 LQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGI 408
Score = 52.4 bits (124), Expect = 3e-06
Identities = 44/148 (29%), Positives = 65/148 (43%), Gaps = 25/148 (16%)
Query: 33 SLEQVPKEIFTFEKTLEELYLDANQIEELPKQLF-NCQSLHKLSLPDNDLTTL-PASIAN 90
SL+++ IF L EL+L N I LP +F N + L L L N ++ + P +
Sbjct: 280 SLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNG 339
Query: 91 LINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFL 150
L LREL + N +Q+ N+ F L NL + L + L
Sbjct: 340 LTELRELSLHTNALQDLDGNV----------------------FRMLANLQNISLQNNRL 377
Query: 151 EFLPAN-FGRLTKLQILELRENQLKMLP 177
LP N F + L ++L+ NQL+ LP
Sbjct: 378 RQLPGNIFANVNGLMAIQLQNNQLENLP 405
>gi|197333706 leucine rich repeat containing 8 family, member D
[Homo sapiens]
Length = 858
Score = 110 bits (276), Expect = 7e-24
Identities = 87/323 (26%), Positives = 153/323 (47%), Gaps = 31/323 (9%)
Query: 71 LHKLSLPDNDLTTLPASIANLINLRELDV-----SKNGIQEFPENIKNCKVLTIVEASVN 125
L L + D+ +PA + L NLREL + S+N E+++ + L I+ N
Sbjct: 539 LRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSN 598
Query: 126 PISKLPDGFSQLL-NLTQLYLNDAFLEFLPAN-FGRLTKLQILELRENQLKMLPKTMNRL 183
++K+P + + +LT+L +++ + L N ++ + LEL+ +L+ +P + L
Sbjct: 599 -LTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSL 657
Query: 184 TQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIE 243
+ L+ LDL SN + E++ LK+LT L + N I
Sbjct: 658 SNLQELDLKSNNIRTIEEIIS---------------------FQHLKRLTCLKLWHNKIV 696
Query: 244 MVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEE 303
+ I+ +NL+ L S+N L+ LP + SL+ + L + N + +P IG L +++
Sbjct: 697 TIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQH 756
Query: 304 LDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEE 363
L + N+V+ LP + + LRT N + LP ++G +T L L N L+ LP +
Sbjct: 757 LHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQ 816
Query: 364 MGDMQKLKVINL--SDNRLKNLP 384
+G + LK L D+ LP
Sbjct: 817 LGQCRMLKKSGLVVEDHLFDTLP 839
Score = 110 bits (274), Expect = 1e-23
Identities = 100/380 (26%), Positives = 175/380 (46%), Gaps = 46/380 (12%)
Query: 42 FTFEKTLEELYLDANQIEEL--------PKQLFNCQSLHKLSLPDNDLTTLPASIANLIN 93
+TFEK + + +A +EL P +F+ L L L +PA I+ + N
Sbjct: 455 WTFEKLRQHISRNAQDKQELHLFMLSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTN 514
Query: 94 LRELDVSKNGIQEFPENIKNCKV------LTIVEASVNPISKLPDGFSQLLNLTQLYLND 147
L+EL + P ++ L + ++++P L NL +LYL
Sbjct: 515 LQELHLC-----HCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYL-- 567
Query: 148 AFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVP----EVL 203
G L EN + +++ L L+ L + SN T+VP +V
Sbjct: 568 ---------IGNLNS-------ENNKMIGLESLRELRHLKILHVKSN-LTKVPSNITDVA 610
Query: 204 EQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSN 263
L+ L D +L + + + + L++ +E + I + NLQ+L L SN
Sbjct: 611 PHLTKLV-IHNDGTKLLVLNS-LKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSN 668
Query: 264 SLQQLPETIG--SLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQL 321
+++ + E I LK +T LK+ N+++ +P SI + ++E L S N++E+LP ++ L
Sbjct: 669 NIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSL 728
Query: 322 TNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLK 381
LR +N + +P EIG +N+ L + NK++ LP+++ KL+ +NL N +
Sbjct: 729 QKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCIT 788
Query: 382 NLPFSFTKLQQLTAMWLSDN 401
+LP +L QLT + L N
Sbjct: 789 SLPEKVGQLSQLTQLELKGN 808
Score = 89.7 bits (221), Expect = 2e-17
Identities = 59/191 (30%), Positives = 101/191 (52%), Gaps = 5/191 (2%)
Query: 24 VTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLS---LPDND 80
V L+ +C LE++P IF+ L+EL L +N I + +++ + Q L +L+ L N
Sbjct: 637 VAELELQNCELERIPHAIFSL-SNLQELDLKSNNIRTI-EEIISFQHLKRLTCLKLWHNK 694
Query: 81 LTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNL 140
+ T+P SI ++ NL L S N ++ P + + + L ++ S N IS +P L NL
Sbjct: 695 IVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNL 754
Query: 141 TQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVP 200
L++ ++ LP + KL+ L L +N + LP+ + +L+QL +L+L N +P
Sbjct: 755 QHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLP 814
Query: 201 EVLEQLSGLKE 211
L Q LK+
Sbjct: 815 AQLGQCRMLKK 825
Score = 89.0 bits (219), Expect = 3e-17
Identities = 74/285 (25%), Positives = 135/285 (47%), Gaps = 9/285 (3%)
Query: 127 ISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQ- 185
+S +PD L +L L L +PA ++T LQ L L K+ + L
Sbjct: 479 LSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDH 538
Query: 186 LERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIG--SLKQLTYLDVS--KNN 241
L L + + E+P + L L+E ++ N + IG SL++L +L + K+N
Sbjct: 539 LRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSN 598
Query: 242 IEMVEEGIS-TCENLQDLLLSSNSLQQLP-ETIGSLKNITTLKIDENQLMYLPDSIGGLI 299
+ V I+ +L L++ ++ + L ++ + N+ L++ +L +P +I L
Sbjct: 599 LTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLS 658
Query: 300 SVEELDCSFNEVEALPSSIG--QLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKL 357
+++ELD N + + I L L HN + +PP I KN+ L+ +NKL
Sbjct: 659 NLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKL 718
Query: 358 ETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQ 402
E+LP + +QKL+ +++S N + +P LQ L + ++ N+
Sbjct: 719 ESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNK 763
>gi|34222199 leucine rich repeat containing 8 family, member D [Homo
sapiens]
Length = 858
Score = 110 bits (276), Expect = 7e-24
Identities = 87/323 (26%), Positives = 153/323 (47%), Gaps = 31/323 (9%)
Query: 71 LHKLSLPDNDLTTLPASIANLINLRELDV-----SKNGIQEFPENIKNCKVLTIVEASVN 125
L L + D+ +PA + L NLREL + S+N E+++ + L I+ N
Sbjct: 539 LRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSN 598
Query: 126 PISKLPDGFSQLL-NLTQLYLNDAFLEFLPAN-FGRLTKLQILELRENQLKMLPKTMNRL 183
++K+P + + +LT+L +++ + L N ++ + LEL+ +L+ +P + L
Sbjct: 599 -LTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSL 657
Query: 184 TQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIE 243
+ L+ LDL SN + E++ LK+LT L + N I
Sbjct: 658 SNLQELDLKSNNIRTIEEIIS---------------------FQHLKRLTCLKLWHNKIV 696
Query: 244 MVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEE 303
+ I+ +NL+ L S+N L+ LP + SL+ + L + N + +P IG L +++
Sbjct: 697 TIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQH 756
Query: 304 LDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEE 363
L + N+V+ LP + + LRT N + LP ++G +T L L N L+ LP +
Sbjct: 757 LHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQ 816
Query: 364 MGDMQKLKVINL--SDNRLKNLP 384
+G + LK L D+ LP
Sbjct: 817 LGQCRMLKKSGLVVEDHLFDTLP 839
Score = 110 bits (274), Expect = 1e-23
Identities = 100/380 (26%), Positives = 175/380 (46%), Gaps = 46/380 (12%)
Query: 42 FTFEKTLEELYLDANQIEEL--------PKQLFNCQSLHKLSLPDNDLTTLPASIANLIN 93
+TFEK + + +A +EL P +F+ L L L +PA I+ + N
Sbjct: 455 WTFEKLRQHISRNAQDKQELHLFMLSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTN 514
Query: 94 LRELDVSKNGIQEFPENIKNCKV------LTIVEASVNPISKLPDGFSQLLNLTQLYLND 147
L+EL + P ++ L + ++++P L NL +LYL
Sbjct: 515 LQELHLC-----HCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYL-- 567
Query: 148 AFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVP----EVL 203
G L EN + +++ L L+ L + SN T+VP +V
Sbjct: 568 ---------IGNLNS-------ENNKMIGLESLRELRHLKILHVKSN-LTKVPSNITDVA 610
Query: 204 EQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSN 263
L+ L D +L + + + + L++ +E + I + NLQ+L L SN
Sbjct: 611 PHLTKLV-IHNDGTKLLVLNS-LKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSN 668
Query: 264 SLQQLPETIG--SLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQL 321
+++ + E I LK +T LK+ N+++ +P SI + ++E L S N++E+LP ++ L
Sbjct: 669 NIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSL 728
Query: 322 TNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLK 381
LR +N + +P EIG +N+ L + NK++ LP+++ KL+ +NL N +
Sbjct: 729 QKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCIT 788
Query: 382 NLPFSFTKLQQLTAMWLSDN 401
+LP +L QLT + L N
Sbjct: 789 SLPEKVGQLSQLTQLELKGN 808
Score = 89.7 bits (221), Expect = 2e-17
Identities = 59/191 (30%), Positives = 101/191 (52%), Gaps = 5/191 (2%)
Query: 24 VTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLS---LPDND 80
V L+ +C LE++P IF+ L+EL L +N I + +++ + Q L +L+ L N
Sbjct: 637 VAELELQNCELERIPHAIFSL-SNLQELDLKSNNIRTI-EEIISFQHLKRLTCLKLWHNK 694
Query: 81 LTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNL 140
+ T+P SI ++ NL L S N ++ P + + + L ++ S N IS +P L NL
Sbjct: 695 IVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNL 754
Query: 141 TQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVP 200
L++ ++ LP + KL+ L L +N + LP+ + +L+QL +L+L N +P
Sbjct: 755 QHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLP 814
Query: 201 EVLEQLSGLKE 211
L Q LK+
Sbjct: 815 AQLGQCRMLKK 825
Score = 89.0 bits (219), Expect = 3e-17
Identities = 74/285 (25%), Positives = 135/285 (47%), Gaps = 9/285 (3%)
Query: 127 ISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQ- 185
+S +PD L +L L L +PA ++T LQ L L K+ + L
Sbjct: 479 LSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDH 538
Query: 186 LERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIG--SLKQLTYLDVS--KNN 241
L L + + E+P + L L+E ++ N + IG SL++L +L + K+N
Sbjct: 539 LRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSN 598
Query: 242 IEMVEEGIS-TCENLQDLLLSSNSLQQLP-ETIGSLKNITTLKIDENQLMYLPDSIGGLI 299
+ V I+ +L L++ ++ + L ++ + N+ L++ +L +P +I L
Sbjct: 599 LTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLS 658
Query: 300 SVEELDCSFNEVEALPSSIG--QLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKL 357
+++ELD N + + I L L HN + +PP I KN+ L+ +NKL
Sbjct: 659 NLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKL 718
Query: 358 ETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQ 402
E+LP + +QKL+ +++S N + +P LQ L + ++ N+
Sbjct: 719 ESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNK 763
>gi|37221175 PH domain and leucine rich repeat protein phosphatase
[Homo sapiens]
Length = 1205
Score = 105 bits (261), Expect = 4e-22
Identities = 110/424 (25%), Positives = 186/424 (43%), Gaps = 63/424 (14%)
Query: 34 LEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLT---TLPAS--- 87
L QV K + + + L +E LP LF Q L L+L N L +LPA+
Sbjct: 116 LRQVSK---VASQRISSVDLSCCSLEHLPANLFYSQDLTHLNLKQNFLRQNPSLPAARGL 172
Query: 88 --IANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYL 145
+ L+ L++S N + +FP + C + T+ E +V+ +
Sbjct: 173 NELQRFTKLKSLNLSNNHLGDFPLAV--CSIPTLAELNVSCNA----------------- 213
Query: 146 NDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQ 205
L +PA G + LQ L N L+ LP + + QL L L NEFT++PEVLE+
Sbjct: 214 ----LRSVPAAVGVMHNLQTFLLDGNFLQSLPAELENMKQLSYLGLSFNEFTDIPEVLEK 269
Query: 206 LSGLKEFWMDANRL-TFIPGFIGSLKQLTYLDVSKNNI-EMVEEGISTCENLQDLLLSSN 263
L+ + + M N + T + + + ++D+ N I +++ + + +++ L L N
Sbjct: 270 LTAVDKLCMSGNCVETLRLQALRKMPHIKHVDLRLNVIRKLIADEVDFLQHVTQLDLRDN 329
Query: 264 SLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLIS--------------------VEE 303
L L I NI L + NQL+ L D G + +
Sbjct: 330 KLGDLDAMI--FNNIEVLHCERNQLVTL-DICGYFLKALYASSNELVQLDVYPVPNYLSY 386
Query: 304 LDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEE 363
+D S N +E +P + + L HN + +LP + ++ L N+L LPE
Sbjct: 387 MDVSRNRLENVPEWVCESRKLEVLDIGHNQICELPARLFCNSSLRKLLAGHNQLARLPER 446
Query: 364 MGDMQKLKVINLSDNRLKNLPFS-FTKLQQLTAMWLSDNQSKPLIP--LQKETDSETQKM 420
+ + ++V+++ N+L LP + K L + S N+ + L P L +ET+S Q++
Sbjct: 447 L-ERTSVEVLDVQHNQLLELPPNLLMKADSLRFLNASANKLESLPPATLSEETNSILQEL 505
Query: 421 VLTN 424
LTN
Sbjct: 506 YLTN 509
Score = 85.5 bits (210), Expect = 3e-16
Identities = 105/429 (24%), Positives = 184/429 (42%), Gaps = 78/429 (18%)
Query: 23 TVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLT 82
T+ L+ S +L VP + L+ LD N ++ LP +L N + L L L N+ T
Sbjct: 203 TLAELNVSCNALRSVPAAVGVMHN-LQTFLLDGNFLQSLPAELENMKQLSYLGLSFNEFT 261
Query: 83 TLPASIANLINLRELDVSKNGIQEFP-ENIKNCKVLTIVEASVNPISKL-PDGFSQLLNL 140
+P + L + +L +S N ++ + ++ + V+ +N I KL D L ++
Sbjct: 262 DIPEVLEKLTAVDKLCMSGNCVETLRLQALRKMPHIKHVDLRLNVIRKLIADEVDFLQHV 321
Query: 141 TQLYLNDA-------------------------------FLEFLPANFGRLTKLQI---- 165
TQL L D FL+ L A+ L +L +
Sbjct: 322 TQLDLRDNKLGDLDAMIFNNIEVLHCERNQLVTLDICGYFLKALYASSNELVQLDVYPVP 381
Query: 166 -----LELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLT 220
+++ N+L+ +P+ + +LE LD+G N+ E+P L S L++ N+L
Sbjct: 382 NYLSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQICELPARLFCNSSLRKLLAGHNQLA 441
Query: 221 FIP-----------------------GFIGSLKQLTYLDVSKNNIEMVEEGISTCEN--- 254
+P + L +L+ S N +E + + E
Sbjct: 442 RLPERLERTSVEVLDVQHNQLLELPPNLLMKADSLRFLNASANKLESLPPATLSEETNSI 501
Query: 255 LQDLLLSSNSLQQ--LPETIGSLKNITTLKIDENQLMYLPDS-IGGLISVEELDCSFNEV 311
LQ+L L++NSL +P G ++ L + N+L P S + L +EE+D S N++
Sbjct: 502 LQELYLTNNSLTDKCVPLLTGH-PHLKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKL 560
Query: 312 EALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLE--TLPEEMGDMQK 369
+A+P++I + T A N ++ PE+ I + L N+L TLPE + K
Sbjct: 561 KAIPTTIMNCRRMHTVIAHSNCIEVF-PEVMQLPEIKCVDLSCNELSEVTLPENL--PPK 617
Query: 370 LKVINLSDN 378
L+ ++L+ N
Sbjct: 618 LQELDLTGN 626
Score = 69.7 bits (169), Expect = 2e-11
Identities = 84/355 (23%), Positives = 149/355 (41%), Gaps = 41/355 (11%)
Query: 33 SLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLI 92
S E V +++ L + + N++E +P+ + + L L + N + LPA +
Sbjct: 369 SNELVQLDVYPVPNYLSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQICELPARLFCNS 428
Query: 93 NLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEF 152
+LR+L N + PE ++ V +++ N + +LP L + L F
Sbjct: 429 SLRKLLAGHNQLARLPERLERTSV-EVLDVQHNQLLELP---------PNLLMKADSLRF 478
Query: 153 LPANFGRLTKLQILELRENQLKMLPKTMNRLTQ--LERLDLGSNEFTE--VPEVLEQLSG 208
L A+ +L L P T++ T L+ L L +N T+ VP +L
Sbjct: 479 LNASANKLESLP------------PATLSEETNSILQELYLTNNSLTDKCVP-LLTGHPH 525
Query: 209 LKEFWMDANRLTFIPGF-IGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQ 267
LK M NRL P + L++L +D+S N ++ + I C + ++ SN ++
Sbjct: 526 LKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLKAIPTTIMNCRRMHTVIAHSNCIEV 585
Query: 268 LPETIGSLKNITTLKIDENQL--MYLPDSIGGLISVEELDCSFNEVEALP-SSIGQLTNL 324
PE + L I + + N+L + LP+++ ++ELD + N L ++ L N+
Sbjct: 586 FPEVM-QLPEIKCVDLSCNELSEVTLPENLPP--KLQELDLTGNPRLVLDHKTLELLNNI 642
Query: 325 RTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNR 379
R F D P G ++ H + + + L V N DNR
Sbjct: 643 RCFKIDQ-------PSTGDASGAPAVWSHGYTEASGVKNKLCVAALSVNNFCDNR 690
Score = 50.1 bits (118), Expect = 1e-05
Identities = 57/200 (28%), Positives = 85/200 (42%), Gaps = 34/200 (17%)
Query: 18 RGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQS---LHKL 74
R E +V LD H L ++P + +L L AN++E LP + ++ L +L
Sbjct: 446 RLERTSVEVLDVQHNQLLELPPNLLMKADSLRFLNASANKLESLPPATLSEETNSILQEL 505
Query: 75 SLPDNDLT------------------------TLPAS-IANLINLRELDVSKNGIQEFPE 109
L +N LT + PAS +A L L E+D+S N ++ P
Sbjct: 506 YLTNNSLTDKCVPLLTGHPHLKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLKAIPT 565
Query: 110 NIKNCKVLTIVEASVNPISKLPDGFSQL--LNLTQLYLNDAFLEFLPANFGRLTKLQILE 167
I NC+ + V A N I P+ QL + L N+ LP N KLQ L+
Sbjct: 566 TIMNCRRMHTVIAHSNCIEVFPE-VMQLPEIKCVDLSCNELSEVTLPENLP--PKLQELD 622
Query: 168 LREN-QLKMLPKTMNRLTQL 186
L N +L + KT+ L +
Sbjct: 623 LTGNPRLVLDHKTLELLNNI 642
Score = 38.9 bits (89), Expect = 0.034
Identities = 36/139 (25%), Positives = 63/139 (45%), Gaps = 8/139 (5%)
Query: 3 TKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELP 62
T SL + VP L G + L ++ L+ P + LEE+ L N+++ +P
Sbjct: 508 TNNSLTDKCVPL--LTGHPH-LKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLKAIP 564
Query: 63 KQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQE--FPENIKNCKVLTIV 120
+ NC+ +H + N + P + L ++ +D+S N + E PEN+ L +
Sbjct: 565 TTIMNCRRMHTVIAHSNCIEVFP-EVMQLPEIKCVDLSCNELSEVTLPENLP--PKLQEL 621
Query: 121 EASVNPISKLPDGFSQLLN 139
+ + NP L +LLN
Sbjct: 622 DLTGNPRLVLDHKTLELLN 640
>gi|4504379 leucine-rich repeat-containing G protein-coupled
receptor 5 [Homo sapiens]
Length = 907
Score = 105 bits (261), Expect = 4e-22
Identities = 117/438 (26%), Positives = 191/438 (43%), Gaps = 68/438 (15%)
Query: 14 CRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEEL-PKQLFNCQSLH 72
C C + + +D S L ++P + F L+ L N I +L P L + + L
Sbjct: 38 CHC-EPDGRMLLRVDCSDLGLSELPSNLSVFTSYLD---LSMNNISQLLPNPLPSLRFLE 93
Query: 73 KLSLPDNDLTTLP-ASIANLINLRELDVSKNGIQEFP-ENIKNCKVLTIVEASVNPISKL 130
+L L N LT +P + L +L+ L + N ++ P E ++N + L + N IS +
Sbjct: 94 ELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYV 153
Query: 131 PDG-FSQLLNLTQLYLNDAFLEFLPAN-------------------------FGRLTKLQ 164
P FS L +L L+L+D L +P FG L+ L
Sbjct: 154 PPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLV 213
Query: 165 ILELRENQLKML-PKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIP 223
+L L N++ L K + L LE LDL N E P + LS LKE +N + IP
Sbjct: 214 VLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIP 273
Query: 224 --GFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDL----LLSSNSLQQLPETIGSLKN 277
F+G+ +T + N I+ V G S ++L +L L ++ + + P+ G+ N
Sbjct: 274 EKAFVGNPSLIT-IHFYDNPIQFV--GRSAFQHLPELRTLTLNGASQITEFPDLTGT-AN 329
Query: 278 ITTLKIDENQLMYLPDSI-GGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQ 336
+ +L + Q+ LP ++ L +++ LD S+N +E LP S L+ HN + +
Sbjct: 330 LESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLP-SFSVCQKLQKIDLRHNEIYE 388
Query: 337 LPPEIG-----------SWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPF 385
+ + +W I + +H N TLP L ++LS N L + P
Sbjct: 389 IKVDTFQQLLSLRSLNLAWNKIAI--IHPNAFSTLP-------SLIKLDLSSNLLSSFP- 438
Query: 386 SFTKLQQLTAMWLSDNQS 403
T L LT + L+ N +
Sbjct: 439 -ITGLHGLTHLKLTGNHA 455
>gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens]
Length = 277
Score = 105 bits (261), Expect = 4e-22
Identities = 75/196 (38%), Positives = 95/196 (48%), Gaps = 24/196 (12%)
Query: 24 VTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTT 83
+T L SH L VP I K LE L NQIEELP Q+ + Q L L+L N L T
Sbjct: 42 ITQLVLSHNKLTMVPPNIAEL-KNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNT 100
Query: 84 LPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQL 143
LP +L L LD++ N + E + LP F L L L
Sbjct: 101 LPRGFGSLPALEVLDLTYNNLSE---------------------NSLPGNFFYLTTLRAL 139
Query: 144 YLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVL 203
YL+D E LP + G+LTKLQIL LR+N L LPK + LTQL+ L + N T +P L
Sbjct: 140 YLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPEL 199
Query: 204 E--QLSGLKEFWMDAN 217
L+G K+ + N
Sbjct: 200 GNLDLTGQKQVFKAEN 215
Score = 98.6 bits (244), Expect = 4e-20
Identities = 59/167 (35%), Positives = 91/167 (54%), Gaps = 2/167 (1%)
Query: 65 LFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASV 124
LF + +L L N LT +P +IA L NL L+ N I+E P I + + L + +
Sbjct: 36 LFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGM 95
Query: 125 NPISKLPDGFSQL--LNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNR 182
N ++ LP GF L L + L N+ LP NF LT L+ L L +N ++LP + +
Sbjct: 96 NRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGK 155
Query: 183 LTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSL 229
LT+L+ L L N+ +P+ + +L+ LKE + NRLT +P +G+L
Sbjct: 156 LTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 202
Score = 98.6 bits (244), Expect = 4e-20
Identities = 55/159 (34%), Positives = 90/159 (56%), Gaps = 2/159 (1%)
Query: 228 SLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQ 287
+L +T L +S N + MV I+ +NL+ L +N +++LP I SL+ + L + N+
Sbjct: 38 TLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNR 97
Query: 288 LMYLPDSIGGLISVEELDCSFNEVE--ALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWK 345
L LP G L ++E LD ++N + +LP + LT LR N + LPP+IG
Sbjct: 98 LNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLT 157
Query: 346 NITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLP 384
+ +L L N L +LP+E+G++ +LK +++ NRL LP
Sbjct: 158 KLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLP 196
Score = 91.7 bits (226), Expect = 4e-18
Identities = 64/207 (30%), Positives = 94/207 (45%), Gaps = 13/207 (6%)
Query: 228 SLKQLTYLDVSKNN--IEMVEEGIS---------TCENLQDLLLSSNSLQQLPETIGSLK 276
SLK+L KN ++M + GIS T ++ L+LS N L +P I LK
Sbjct: 4 SLKKLVEESREKNQPEVDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIAELK 63
Query: 277 NITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQ 336
N+ L NQ+ LP I L ++ L+ N + LP G L L +N L +
Sbjct: 64 NLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSE 123
Query: 337 --LPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLT 394
LP + L+L N E LP ++G + KL++++L DN L +LP +L QL
Sbjct: 124 NSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLK 183
Query: 395 AMWLSDNQSKPLIPLQKETDSETQKMV 421
+ + N+ L P D QK V
Sbjct: 184 ELHIQGNRLTVLPPELGNLDLTGQKQV 210
Score = 86.3 bits (212), Expect = 2e-16
Identities = 57/178 (32%), Positives = 86/178 (48%), Gaps = 5/178 (2%)
Query: 160 LTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRL 219
L+ + L L N+L M+P + L LE L+ +N+ E+P + L LK + NRL
Sbjct: 39 LSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRL 98
Query: 220 TFIPGFIGSLKQLTYLDVSKNNI--EMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKN 277
+P GSL L LD++ NN+ + L+ L LS N + LP IG L
Sbjct: 99 NTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTK 158
Query: 278 ITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLT---NLRTFAADHN 332
+ L + +N L+ LP IG L ++EL N + LP +G L + F A++N
Sbjct: 159 LQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAENN 216
Score = 55.1 bits (131), Expect = 5e-07
Identities = 38/115 (33%), Positives = 54/115 (46%), Gaps = 5/115 (4%)
Query: 24 VTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTT 83
V L Y++ S +P F + TL LYL N E LP + L LSL DNDL +
Sbjct: 113 VLDLTYNNLSENSLPGNFF-YLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLIS 171
Query: 84 LPASIANLINLRELDVSKNGIQEFPENIKNCKVL---TIVEASVNP-ISKLPDGF 134
LP I L L+EL + N + P + N + + +A NP ++ + D F
Sbjct: 172 LPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAENNPWVTPIADQF 226
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.129 0.363
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 54,869,472
Number of Sequences: 37866
Number of extensions: 2670262
Number of successful extensions: 11405
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 157
Number of HSP's successfully gapped in prelim test: 448
Number of HSP's that attempted gapping in prelim test: 7857
Number of HSP's gapped (non-prelim): 2051
length of query: 1371
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1256
effective length of database: 13,892,928
effective search space: 17449517568
effective search space used: 17449517568
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.