Guide to the Human Genome
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Search of human proteins with 8923909

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens]
         (1371 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens]        2735   0.0  
gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens]       2411   0.0  
gi|16904383 leucine rich repeat containing 7 [Homo sapiens]           698   0.0  
gi|45827729 scribble isoform b [Homo sapiens]                         389   e-107
gi|45827731 scribble isoform a [Homo sapiens]                         389   e-107
gi|95113664 leucine rich repeat containing 1 [Homo sapiens]           375   e-103
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]          190   9e-48
gi|122937315 leucine-rich repeats and IQ motif containing 4 [Hom...   173   9e-43
gi|238908508 leucine-rich repeat and death domain-containing pro...   170   8e-42
gi|110825984 malignant fibrous histiocytoma amplified sequence 1...   150   6e-36
gi|21361633 leucine rich repeat containing 40 [Homo sapiens]          149   2e-35
gi|4503743 flightless I homolog [Homo sapiens]                        139   2e-32
gi|65301141 PH domain and leucine rich repeat protein phosphatas...   124   8e-28
gi|197333692 leucine rich repeat containing 8 family, member B [...   123   1e-27
gi|21245134 leucine rich repeat containing 8 family, member B [H...   123   1e-27
gi|40217803 leucine rich repeat containing 8 family, member E [H...   120   7e-27
gi|62241040 leucine rich repeat containing 8 family, member A [H...   115   4e-25
gi|187829877 leucine rich repeat containing 8 family, member A [...   115   4e-25
gi|187829871 leucine rich repeat containing 8 family, member A [...   115   4e-25
gi|21389431 leucine rich repeat containing 39 [Homo sapiens]          114   8e-25
gi|19923729 leucine rich repeat containing 8 family, member C [H...   112   2e-24
gi|61742786 leucine rich repeat and death domain containing prot...   112   3e-24
gi|61742784 leucine rich repeat and death domain containing prot...   112   3e-24
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s...   111   4e-24
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa...   111   4e-24
gi|197333706 leucine rich repeat containing 8 family, member D [...   110   7e-24
gi|34222199 leucine rich repeat containing 8 family, member D [H...   110   7e-24
gi|37221175 PH domain and leucine rich repeat protein phosphatas...   105   4e-22
gi|4504379 leucine-rich repeat-containing G protein-coupled rece...   105   4e-22
gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens]          105   4e-22

>gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens]
          Length = 1371

 Score = 2735 bits (7089), Expect = 0.0
 Identities = 1371/1371 (100%), Positives = 1371/1371 (100%)

Query: 1    MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEE 60
            MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEE
Sbjct: 1    MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEE 60

Query: 61   LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIV 120
            LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIV
Sbjct: 61   LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIV 120

Query: 121  EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM 180
            EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM
Sbjct: 121  EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM 180

Query: 181  NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN 240
            NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN
Sbjct: 181  NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN 240

Query: 241  NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLIS 300
            NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLIS
Sbjct: 241  NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLIS 300

Query: 301  VEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL 360
            VEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL
Sbjct: 301  VEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL 360

Query: 361  PEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKM 420
            PEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKM
Sbjct: 361  PEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKM 420

Query: 421  VLTNYMFPQQPRTEDVMFISDNESFNPSLWEEQRKQRAQVAFECDEDKDEREAPPREGNL 480
            VLTNYMFPQQPRTEDVMFISDNESFNPSLWEEQRKQRAQVAFECDEDKDEREAPPREGNL
Sbjct: 421  VLTNYMFPQQPRTEDVMFISDNESFNPSLWEEQRKQRAQVAFECDEDKDEREAPPREGNL 480

Query: 481  KRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTT 540
            KRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTT
Sbjct: 481  KRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTT 540

Query: 541  TVKSKVDEREKYMIGNSVQKISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESEE 600
            TVKSKVDEREKYMIGNSVQKISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESEE
Sbjct: 541  TVKSKVDEREKYMIGNSVQKISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESEE 600

Query: 601  LSSDEEMKMAEMRPPLIETSINQPKVVALSNNKKDDTKETDSLSDEVTHNSNQNNSNCSS 660
            LSSDEEMKMAEMRPPLIETSINQPKVVALSNNKKDDTKETDSLSDEVTHNSNQNNSNCSS
Sbjct: 601  LSSDEEMKMAEMRPPLIETSINQPKVVALSNNKKDDTKETDSLSDEVTHNSNQNNSNCSS 660

Query: 661  PSRMSDSVSLNTDSSQDTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTEEKF 720
            PSRMSDSVSLNTDSSQDTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTEEKF
Sbjct: 661  PSRMSDSVSLNTDSSQDTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTEEKF 720

Query: 721  KAHDKKDFNLPEYDLNVEERLVLIEKSVDSTATADDTHKLDHINMNLNKLITNDTFQPEI 780
            KAHDKKDFNLPEYDLNVEERLVLIEKSVDSTATADDTHKLDHINMNLNKLITNDTFQPEI
Sbjct: 721  KAHDKKDFNLPEYDLNVEERLVLIEKSVDSTATADDTHKLDHINMNLNKLITNDTFQPEI 780

Query: 781  MERSKTQDIVLGTSFLSINSKEETEHLENGNKYPNLESVNKVNGHSEETSQSPNRTEPHD 840
            MERSKTQDIVLGTSFLSINSKEETEHLENGNKYPNLESVNKVNGHSEETSQSPNRTEPHD
Sbjct: 781  MERSKTQDIVLGTSFLSINSKEETEHLENGNKYPNLESVNKVNGHSEETSQSPNRTEPHD 840

Query: 841  SDCSVDLGISKSTEDLSPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNGPQQPSTTVK 900
            SDCSVDLGISKSTEDLSPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNGPQQPSTTVK
Sbjct: 841  SDCSVDLGISKSTEDLSPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNGPQQPSTTVK 900

Query: 901  ITSAVDGKNIVRSKSATLLYDQPLQVFTGSSSSSDLISGTKAIFKFDSNHNPEEPNIIRG 960
            ITSAVDGKNIVRSKSATLLYDQPLQVFTGSSSSSDLISGTKAIFKFDSNHNPEEPNIIRG
Sbjct: 901  ITSAVDGKNIVRSKSATLLYDQPLQVFTGSSSSSDLISGTKAIFKFDSNHNPEEPNIIRG 960

Query: 961  PTSGPQSAPQIYGPPQYNIQYSSSAAVKDTLWHSKQNPQIDHASFPPQLLPRSESTENQS 1020
            PTSGPQSAPQIYGPPQYNIQYSSSAAVKDTLWHSKQNPQIDHASFPPQLLPRSESTENQS
Sbjct: 961  PTSGPQSAPQIYGPPQYNIQYSSSAAVKDTLWHSKQNPQIDHASFPPQLLPRSESTENQS 1020

Query: 1021 YAKHSANMNFSNHNNVRANTAYHLHQRLGPARHGEMWAISPNDRLIPAVTRSTIQRQSSV 1080
            YAKHSANMNFSNHNNVRANTAYHLHQRLGPARHGEMWAISPNDRLIPAVTRSTIQRQSSV
Sbjct: 1021 YAKHSANMNFSNHNNVRANTAYHLHQRLGPARHGEMWAISPNDRLIPAVTRSTIQRQSSV 1080

Query: 1081 SSTASVNLGDPGSTRRAQIPEGDYLSYREFHSAGRTPPMMPGSQRPLSARTYSIDGPNAS 1140
            SSTASVNLGDPGSTRRAQIPEGDYLSYREFHSAGRTPPMMPGSQRPLSARTYSIDGPNAS
Sbjct: 1081 SSTASVNLGDPGSTRRAQIPEGDYLSYREFHSAGRTPPMMPGSQRPLSARTYSIDGPNAS 1140

Query: 1141 RPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNARVGSEHSLLDPPGKSKVPRDWREQV 1200
            RPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNARVGSEHSLLDPPGKSKVPRDWREQV
Sbjct: 1141 RPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNARVGSEHSLLDPPGKSKVPRDWREQV 1200

Query: 1201 LRHIEAKKLEKMPLSNGQMGQPLRPQANYSQIHHPPQASVARHPSREQLIDYLMLKVAHQ 1260
            LRHIEAKKLEKMPLSNGQMGQPLRPQANYSQIHHPPQASVARHPSREQLIDYLMLKVAHQ
Sbjct: 1201 LRHIEAKKLEKMPLSNGQMGQPLRPQANYSQIHHPPQASVARHPSREQLIDYLMLKVAHQ 1260

Query: 1261 PPYTQPHCSPRQGHELAKQEIRVRVEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQP 1320
            PPYTQPHCSPRQGHELAKQEIRVRVEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQP
Sbjct: 1261 PPYTQPHCSPRQGHELAKQEIRVRVEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQP 1320

Query: 1321 EGPASKLLQPGDKIIQANGYSFINIEHGQAVSLLKTFQNTVELIIVREVSS 1371
            EGPASKLLQPGDKIIQANGYSFINIEHGQAVSLLKTFQNTVELIIVREVSS
Sbjct: 1321 EGPASKLLQPGDKIIQANGYSFINIEHGQAVSLLKTFQNTVELIIVREVSS 1371


>gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens]
          Length = 1302

 Score = 2411 bits (6248), Expect = 0.0
 Identities = 1211/1212 (99%), Positives = 1212/1212 (100%)

Query: 1    MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEE 60
            MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEE
Sbjct: 1    MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEE 60

Query: 61   LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIV 120
            LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIV
Sbjct: 61   LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIV 120

Query: 121  EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM 180
            EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM
Sbjct: 121  EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM 180

Query: 181  NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN 240
            NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN
Sbjct: 181  NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN 240

Query: 241  NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLIS 300
            NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLIS
Sbjct: 241  NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLIS 300

Query: 301  VEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL 360
            VEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL
Sbjct: 301  VEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL 360

Query: 361  PEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKM 420
            PEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKM
Sbjct: 361  PEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKM 420

Query: 421  VLTNYMFPQQPRTEDVMFISDNESFNPSLWEEQRKQRAQVAFECDEDKDEREAPPREGNL 480
            VLTNYMFPQQPRTEDVMFISDNESFNPSLWEEQRKQRAQVAFECDEDKDEREAPPREGNL
Sbjct: 421  VLTNYMFPQQPRTEDVMFISDNESFNPSLWEEQRKQRAQVAFECDEDKDEREAPPREGNL 480

Query: 481  KRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTT 540
            KRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTT
Sbjct: 481  KRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTT 540

Query: 541  TVKSKVDEREKYMIGNSVQKISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESEE 600
            TVKSKVDEREKYMIGNSVQKISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESEE
Sbjct: 541  TVKSKVDEREKYMIGNSVQKISEPEAEISPGSLPVTANMKASENLKHIVNHDDVFEESEE 600

Query: 601  LSSDEEMKMAEMRPPLIETSINQPKVVALSNNKKDDTKETDSLSDEVTHNSNQNNSNCSS 660
            LSSDEEMKMAEMRPPLIETSINQPKVVALSNNKKDDTKETDSLSDEVTHNSNQNNSNCSS
Sbjct: 601  LSSDEEMKMAEMRPPLIETSINQPKVVALSNNKKDDTKETDSLSDEVTHNSNQNNSNCSS 660

Query: 661  PSRMSDSVSLNTDSSQDTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTEEKF 720
            PSRMSDSVSLNTDSSQDTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTEEKF
Sbjct: 661  PSRMSDSVSLNTDSSQDTSLCSPVKQTHIDINSKIRQEDENFNSLLQNGDILNSSTEEKF 720

Query: 721  KAHDKKDFNLPEYDLNVEERLVLIEKSVDSTATADDTHKLDHINMNLNKLITNDTFQPEI 780
            KAHDKKDFNLPEYDLNVEERLVLIEKSVDSTATADDTHKLDHINMNLNKLITNDTFQPEI
Sbjct: 721  KAHDKKDFNLPEYDLNVEERLVLIEKSVDSTATADDTHKLDHINMNLNKLITNDTFQPEI 780

Query: 781  MERSKTQDIVLGTSFLSINSKEETEHLENGNKYPNLESVNKVNGHSEETSQSPNRTEPHD 840
            MERSKTQDIVLGTSFLSINSKEETEHLENGNKYPNLESVNKVNGHSEETSQSPNRTEPHD
Sbjct: 781  MERSKTQDIVLGTSFLSINSKEETEHLENGNKYPNLESVNKVNGHSEETSQSPNRTEPHD 840

Query: 841  SDCSVDLGISKSTEDLSPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNGPQQPSTTVK 900
            SDCSVDLGISKSTEDLSPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNGPQQPSTTVK
Sbjct: 841  SDCSVDLGISKSTEDLSPQKSGPVGSVVKSHSITNMEIGGLKIYDILSDNGPQQPSTTVK 900

Query: 901  ITSAVDGKNIVRSKSATLLYDQPLQVFTGSSSSSDLISGTKAIFKFDSNHNPEEPNIIRG 960
            ITSAVDGKNIVRSKSATLLYDQPLQVFTGSSSSSDLISGTKAIFKFDSNHNPEEPNIIRG
Sbjct: 901  ITSAVDGKNIVRSKSATLLYDQPLQVFTGSSSSSDLISGTKAIFKFDSNHNPEEPNIIRG 960

Query: 961  PTSGPQSAPQIYGPPQYNIQYSSSAAVKDTLWHSKQNPQIDHASFPPQLLPRSESTENQS 1020
            PTSGPQSAPQIYGPPQYNIQYSSSAAVKDTLWHSKQNPQIDHASFPPQLLPRSESTENQS
Sbjct: 961  PTSGPQSAPQIYGPPQYNIQYSSSAAVKDTLWHSKQNPQIDHASFPPQLLPRSESTENQS 1020

Query: 1021 YAKHSANMNFSNHNNVRANTAYHLHQRLGPARHGEMWAISPNDRLIPAVTRSTIQRQSSV 1080
            YAKHSANMNFSNHNNVRANTAYHLHQRLGPARHGEMWAISPNDRLIPAVTRSTIQRQSSV
Sbjct: 1021 YAKHSANMNFSNHNNVRANTAYHLHQRLGPARHGEMWAISPNDRLIPAVTRSTIQRQSSV 1080

Query: 1081 SSTASVNLGDPGSTRRAQIPEGDYLSYREFHSAGRTPPMMPGSQRPLSARTYSIDGPNAS 1140
            SSTASVNLGDPGSTRRAQIPEGDYLSYREFHSAGRTPPMMPGSQRPLSARTYSIDGPNAS
Sbjct: 1081 SSTASVNLGDPGSTRRAQIPEGDYLSYREFHSAGRTPPMMPGSQRPLSARTYSIDGPNAS 1140

Query: 1141 RPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNARVGSEHSLLDPPGKSKVPRDWREQV 1200
            RPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNARVGSEHSLLDPPGKSKVPRDWREQV
Sbjct: 1141 RPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNARVGSEHSLLDPPGKSKVPRDWREQV 1200

Query: 1201 LRHIEAKKLEKM 1212
            LRHIEAKKLEK+
Sbjct: 1201 LRHIEAKKLEKI 1212


>gi|16904383 leucine rich repeat containing 7 [Homo sapiens]
          Length = 1537

 Score =  698 bits (1801), Expect = 0.0
 Identities = 385/708 (54%), Positives = 481/708 (67%), Gaps = 42/708 (5%)

Query: 1   MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEE 60
           MTTKR +  RLVPCRC RGEEE ++ LDYSHCSL+QVPKE+F FE+TLEELYLDANQIEE
Sbjct: 1   MTTKRKIIGRLVPCRCFRGEEEIISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEE 60

Query: 61  LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIV 120
           LPKQLFNCQ+L KLS+PDNDL+ LP +IA+L+NL+ELD+SKNG+QEFPENIK CK LTI+
Sbjct: 61  LPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTII 120

Query: 121 EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM 180
           EASVNPISKLPDGF+QLLNLTQLYLNDAFLEFLPANFGRL KL+ILELREN LK LPK+M
Sbjct: 121 EASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSM 180

Query: 181 NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN 240
           ++L QLERLDLG+NEF E+PEVL+Q+  L+E WMD N L  +PG IG LK L YLD+SKN
Sbjct: 181 HKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKN 240

Query: 241 NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLIS 300
            IE V+  IS CE L+DLLLSSN LQQLP++IG LK +TTLK+D+NQL  LP++IG L  
Sbjct: 241 RIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSL 300

Query: 301 VEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETL 360
           +EE DCS NE+E+LPS+IG L +LRT A D N+L +LP EIGS KN+TV+ L SNKLE L
Sbjct: 301 LEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFL 360

Query: 361 PEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKM 420
           PEE+G MQKL+V+NLSDNRLKNLPFSFTKL++L A+WLSDNQSK LIPLQ E   ET++ 
Sbjct: 361 PEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKALIPLQTEAHPETKQR 420

Query: 421 VLTNYMFPQQPRTEDVMFISDNESFNPSLWEEQRKQRAQVAFECDEDKDEREAPPREGNL 480
           VLTNYMFPQQPR  D  F SD++SFNP+LWEEQR+QR  VAFE ++ K++ E     G +
Sbjct: 421 VLTNYMFPQQPR-GDEDFQSDSDSFNPTLWEEQRQQRMTVAFEFEDKKEDDE---NAGKV 476

Query: 481 KRYPTPYPDELKNMVKTVQTIVHRLKDEETNEDSGRDLK------PHED----------- 523
           K      P E      T+Q    RL  +     +  D +      P  D           
Sbjct: 477 KDLSCQAPWERGQRGITLQPA--RLSGDCCTPWARCDQQIQDMPVPQNDPQLAWGCISGL 534

Query: 524 QQDINKDVGVKTSESTTTVKS---------------KVDEREKYMIGNSVQKISEPEAEI 568
           QQ+ +    +  +  +TT+ S                  E  K M+ +    + +P   +
Sbjct: 535 QQERSMCTPLPVAAQSTTLPSLSGRQVEINLKRYPTPYPEDLKNMVKSVQNLVGKPSHGV 594

Query: 569 SPGSLPVTAN----MKASENLKHIVNHDDVFEESEELSSDEEMKMAEMRPPLIETSINQP 624
              +   TAN    +K     K  V   ++  E   +    EM++ E+ P L ET +  P
Sbjct: 595 RVENSNPTANTEQTVKEKYEHKWPVAPKEITVEDSFVHPANEMRIGELHPSLAETPLYPP 654

Query: 625 KVVALSNNKKDDTKETDSLSDEVTHNSNQNNSNCSSPSRMSDSVSLNT 672
           K+V L  +KK+ T E++       +NS  + +        + S S NT
Sbjct: 655 KLVLLGKDKKESTDESEVDKTHCLNNSVSSGTYSDYSPSQASSGSSNT 702



 Score =  139 bits (349), Expect = 2e-32
 Identities = 63/92 (68%), Positives = 82/92 (89%)

Query: 1279 QEIRVRVEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKLLQPGDKIIQAN 1338
            ++  VR+EK+P LGFSISGG+ G+GNPF+P D GIFVTRVQP+GPAS LLQPGDKI+QAN
Sbjct: 1445 EQFCVRIEKNPGLGFSISGGISGQGNPFKPSDKGIFVTRVQPDGPASNLLQPGDKILQAN 1504

Query: 1339 GYSFINIEHGQAVSLLKTFQNTVELIIVREVS 1370
            G+SF+++EH +AV LLK+FQNTV+L+I RE++
Sbjct: 1505 GHSFVHMEHEKAVLLLKSFQNTVDLVIQRELT 1536


>gi|45827729 scribble isoform b [Homo sapiens]
          Length = 1630

 Score =  389 bits (998), Expect = e-107
 Identities = 225/553 (40%), Positives = 333/553 (60%), Gaps = 15/553 (2%)

Query: 24  VTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTT 83
           V ++D  HCSL+ VP+EI+ + ++LEEL LDANQ+ ELPK  F   +L KL L DN++  
Sbjct: 14  VESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQR 73

Query: 84  LPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQL 143
           LP  +AN + L ELDVS+N I E PE+IK CK L I + S NP+S+LPDGF+QL +L  L
Sbjct: 74  LPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHL 133

Query: 144 YLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVL 203
            LND  L+ LP + G L  L  LELREN LK LP +++ L +LE+LDLG N+   +P+ L
Sbjct: 134 ALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTL 193

Query: 204 EQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSN 263
             L  L+E W+D N+L+ +P  +G+L++L  LDVS+N +E +   +     L DLLLS N
Sbjct: 194 GALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQN 253

Query: 264 SLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTN 323
            L++LP+ IG LK ++ LK+D+N+L  + ++IG   ++ EL  + N + ALP S+G+LT 
Sbjct: 254 LLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTK 313

Query: 324 LRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNL 383
           L     D N+L+ LPPEIG    ++VL L  N+L  LP E+    +L V++++ NRL++L
Sbjct: 314 LTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSL 373

Query: 384 PFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQP--RTEDVMFISD 441
           PF+ T L  L A+WL++NQ++P++  Q E D+ T + VLT Y+ PQQP    ED    + 
Sbjct: 374 PFALTHL-NLKALWLAENQAQPMLRFQTEDDARTGEKVLTCYLLPQQPPLSLED----AG 428

Query: 442 NESFNPSLWEEQRKQRAQVAFECDE---DKDEREAPPREGNLKRYPTPYPDELKNMVKTV 498
            +      W +    R  V    +    D+D  EA   +  L+R  TP+P ELK M +++
Sbjct: 429 QQGSLSETWSDAPPSRVSVIQFLEAPIGDEDAEEAAAEKRGLQRRATPHPSELKVMKRSI 488

Query: 499 QTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTTTVKSKVDEREKYMIGNSV 558
           +    R +      DSG  L P E+++ ++ + G+  SE +    S V E E        
Sbjct: 489 EG--RRSEACPCQPDSGSPL-PAEEEKRLSAESGL--SEDSRPSASTVSEAEPEGPSAEA 543

Query: 559 QKISEPEAEISPG 571
           Q  S+ EA  + G
Sbjct: 544 QGGSQQEATTAGG 556



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 32/79 (40%), Positives = 51/79 (64%), Gaps = 3/79 (3%)

Query: 1291 LGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKL-LQPGDKIIQANGYSFINIEHGQ 1349
            LG SI+GG G    P++ DD+GIF++RV  EGPA++  ++ GDK+++ NG +    EH +
Sbjct: 738  LGISIAGGKGS--TPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLEVNGVALQGAEHHE 795

Query: 1350 AVSLLKTFQNTVELIIVRE 1368
            AV  L+     V++ + RE
Sbjct: 796  AVEALRGAGTAVQMRVWRE 814



 Score = 62.4 bits (150), Expect = 3e-09
 Identities = 37/105 (35%), Positives = 52/105 (49%), Gaps = 4/105 (3%)

Query: 1266 PHCSPRQGHELAKQEIRVRVEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPAS 1325
            P   P     L ++ +      +  LGFSI+GG G    P+R  D GIFV+R+   G A 
Sbjct: 847  PLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGS--TPYRAGDAGIFVSRIAEGGAAH 904

Query: 1326 KL--LQPGDKIIQANGYSFINIEHGQAVSLLKTFQNTVELIIVRE 1368
            +   LQ GD+++  NG       H  AVSLL     T+ L++ RE
Sbjct: 905  RAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLERE 949



 Score = 61.2 bits (147), Expect = 6e-09
 Identities = 31/90 (34%), Positives = 55/90 (61%), Gaps = 3/90 (3%)

Query: 1279 QEIRVRVEKDPELGFSISGGVGGR-GNPFRPDDDGIFVTRVQPEGPASK--LLQPGDKII 1335
            +E+ ++      LG SI GG  G  GNP  P D+GIF+++V P G A +   L+ G +++
Sbjct: 1099 RELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLL 1158

Query: 1336 QANGYSFINIEHGQAVSLLKTFQNTVELII 1365
            + N  S + + HG+AV LL++  +T+ +++
Sbjct: 1159 EVNQQSLLGLTHGEAVQLLRSVGDTLTVLV 1188



 Score = 48.1 bits (113), Expect = 6e-05
 Identities = 29/77 (37%), Positives = 44/77 (57%), Gaps = 2/77 (2%)

Query: 1279 QEIRVRVEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKL-LQPGDKIIQA 1337
            +EIR+     P LG SI GG     +PF   + G+F+++V P G A++  L+ GD+I+  
Sbjct: 1003 EEIRLPRAGGP-LGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVGDRILAV 1061

Query: 1338 NGYSFINIEHGQAVSLL 1354
            NG    +  H +AVS L
Sbjct: 1062 NGQDVRDATHQEAVSAL 1078


>gi|45827731 scribble isoform a [Homo sapiens]
          Length = 1655

 Score =  389 bits (998), Expect = e-107
 Identities = 225/553 (40%), Positives = 333/553 (60%), Gaps = 15/553 (2%)

Query: 24  VTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTT 83
           V ++D  HCSL+ VP+EI+ + ++LEEL LDANQ+ ELPK  F   +L KL L DN++  
Sbjct: 14  VESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQR 73

Query: 84  LPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQL 143
           LP  +AN + L ELDVS+N I E PE+IK CK L I + S NP+S+LPDGF+QL +L  L
Sbjct: 74  LPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHL 133

Query: 144 YLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVL 203
            LND  L+ LP + G L  L  LELREN LK LP +++ L +LE+LDLG N+   +P+ L
Sbjct: 134 ALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTL 193

Query: 204 EQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSN 263
             L  L+E W+D N+L+ +P  +G+L++L  LDVS+N +E +   +     L DLLLS N
Sbjct: 194 GALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQN 253

Query: 264 SLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTN 323
            L++LP+ IG LK ++ LK+D+N+L  + ++IG   ++ EL  + N + ALP S+G+LT 
Sbjct: 254 LLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTK 313

Query: 324 LRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNL 383
           L     D N+L+ LPPEIG    ++VL L  N+L  LP E+    +L V++++ NRL++L
Sbjct: 314 LTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSL 373

Query: 384 PFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQP--RTEDVMFISD 441
           PF+ T L  L A+WL++NQ++P++  Q E D+ T + VLT Y+ PQQP    ED    + 
Sbjct: 374 PFALTHL-NLKALWLAENQAQPMLRFQTEDDARTGEKVLTCYLLPQQPPLSLED----AG 428

Query: 442 NESFNPSLWEEQRKQRAQVAFECDE---DKDEREAPPREGNLKRYPTPYPDELKNMVKTV 498
            +      W +    R  V    +    D+D  EA   +  L+R  TP+P ELK M +++
Sbjct: 429 QQGSLSETWSDAPPSRVSVIQFLEAPIGDEDAEEAAAEKRGLQRRATPHPSELKVMKRSI 488

Query: 499 QTIVHRLKDEETNEDSGRDLKPHEDQQDINKDVGVKTSESTTTVKSKVDEREKYMIGNSV 558
           +    R +      DSG  L P E+++ ++ + G+  SE +    S V E E        
Sbjct: 489 EG--RRSEACPCQPDSGSPL-PAEEEKRLSAESGL--SEDSRPSASTVSEAEPEGPSAEA 543

Query: 559 QKISEPEAEISPG 571
           Q  S+ EA  + G
Sbjct: 544 QGGSQQEATTAGG 556



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 32/79 (40%), Positives = 51/79 (64%), Gaps = 3/79 (3%)

Query: 1291 LGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKL-LQPGDKIIQANGYSFINIEHGQ 1349
            LG SI+GG G    P++ DD+GIF++RV  EGPA++  ++ GDK+++ NG +    EH +
Sbjct: 738  LGISIAGGKGS--TPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLEVNGVALQGAEHHE 795

Query: 1350 AVSLLKTFQNTVELIIVRE 1368
            AV  L+     V++ + RE
Sbjct: 796  AVEALRGAGTAVQMRVWRE 814



 Score = 62.4 bits (150), Expect = 3e-09
 Identities = 37/105 (35%), Positives = 52/105 (49%), Gaps = 4/105 (3%)

Query: 1266 PHCSPRQGHELAKQEIRVRVEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPAS 1325
            P   P     L ++ +      +  LGFSI+GG G    P+R  D GIFV+R+   G A 
Sbjct: 847  PLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGS--TPYRAGDAGIFVSRIAEGGAAH 904

Query: 1326 KL--LQPGDKIIQANGYSFINIEHGQAVSLLKTFQNTVELIIVRE 1368
            +   LQ GD+++  NG       H  AVSLL     T+ L++ RE
Sbjct: 905  RAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLERE 949



 Score = 61.2 bits (147), Expect = 6e-09
 Identities = 31/90 (34%), Positives = 55/90 (61%), Gaps = 3/90 (3%)

Query: 1279 QEIRVRVEKDPELGFSISGGVGGR-GNPFRPDDDGIFVTRVQPEGPASK--LLQPGDKII 1335
            +E+ ++      LG SI GG  G  GNP  P D+GIF+++V P G A +   L+ G +++
Sbjct: 1099 RELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLL 1158

Query: 1336 QANGYSFINIEHGQAVSLLKTFQNTVELII 1365
            + N  S + + HG+AV LL++  +T+ +++
Sbjct: 1159 EVNQQSLLGLTHGEAVQLLRSVGDTLTVLV 1188



 Score = 48.1 bits (113), Expect = 6e-05
 Identities = 29/77 (37%), Positives = 44/77 (57%), Gaps = 2/77 (2%)

Query: 1279 QEIRVRVEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKL-LQPGDKIIQA 1337
            +EIR+     P LG SI GG     +PF   + G+F+++V P G A++  L+ GD+I+  
Sbjct: 1003 EEIRLPRAGGP-LGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVGDRILAV 1061

Query: 1338 NGYSFINIEHGQAVSLL 1354
            NG    +  H +AVS L
Sbjct: 1062 NGQDVRDATHQEAVSAL 1078


>gi|95113664 leucine rich repeat containing 1 [Homo sapiens]
          Length = 524

 Score =  375 bits (962), Expect = e-103
 Identities = 213/514 (41%), Positives = 308/514 (59%), Gaps = 16/514 (3%)

Query: 24  VTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTT 83
           V ++D  HCSL  VP+EI+ + ++LEEL LDANQ+ ELP+Q F    L KL L DN++  
Sbjct: 14  VESIDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQR 73

Query: 84  LPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQL 143
           LP  IAN + L ELDVS+N I E PE+I  CK L + + S NP+++LP+ F +L NLT L
Sbjct: 74  LPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTCL 133

Query: 144 YLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVL 203
            +ND  L+ LP N G L  L  LELREN L  LP ++ +L +LE LDLG+NE   +PE +
Sbjct: 134 SVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESI 193

Query: 204 EQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSN 263
             L  LK+ W+D N+L+ +P  IG+LK L  LDVS+N +E + E IS   +L DL++S N
Sbjct: 194 GALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQN 253

Query: 264 SLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTN 323
            L+ +P+ IG LK ++ LK+D+N+L  LP+++G   S+ EL  + N++  LP SIG+L  
Sbjct: 254 LLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKK 313

Query: 324 LRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNL 383
           L    AD N L  LP EIG   ++TV  +  N+L  +P E+    +L V++++ NRL +L
Sbjct: 314 LSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHL 373

Query: 384 PFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQPR----TEDVMFI 439
           P S T L +L A+WLSDNQS+PL+  Q +TD  T + +LT  + PQ P      E++   
Sbjct: 374 PLSLTAL-KLKALWLSDNQSQPLLTFQTDTDYTTGEKILTCVLLPQLPSEPTCQENLPRC 432

Query: 440 SDNESF----NPSLWEEQRKQRAQVAFECDEDKDEREAPPREGNLKRYPTPYPDELKNMV 495
              E+     +   W E+   R       +++KDE +   R   L R  TP+P ELK+M 
Sbjct: 433 GALENLVNDVSDEAWNERAVNRVSAIRFVEDEKDEEDNETR--TLLRRATPHPGELKHMK 490

Query: 496 KTVQTIVHRLKDEETNEDSGRDLKPHEDQQDINK 529
           KTV+ +       + N   G D   +E    I++
Sbjct: 491 KTVENL-----RNDMNAAKGLDSNKNEVNHAIDR 519


>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
          Length = 582

 Score =  190 bits (482), Expect = 9e-48
 Identities = 132/453 (29%), Positives = 208/453 (45%), Gaps = 50/453 (11%)

Query: 21  EETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDND 80
           EE    LD S  S+  +P  I    + L ELYL +N+++ LP ++    +L  L+L +N 
Sbjct: 99  EENSMRLDLSKRSIHILPSSIKELTQ-LTELYLYSNKLQSLPAEVGCLVNLMTLALSENS 157

Query: 81  LTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNL 140
           LT+LP S+ NL  LR LD+  N ++E P  +     LT +    N I+ +      L  L
Sbjct: 158 LTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKL 217

Query: 141 TQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVP 200
           + L + +  ++ LPA  G L  L  L++  NQL+ LPK +   TQ+  LDL  NE  ++P
Sbjct: 218 SMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLP 277

Query: 201 EVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGI----------- 249
           + +  LS L    +  NRL+ IP  +     L  L++  NNI  + E +           
Sbjct: 278 DTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLT 337

Query: 250 --------------------------------------STCENLQDLLLSSNSLQQLPET 271
                                                 S  + L  L +  N L  LP  
Sbjct: 338 LARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLD 397

Query: 272 IGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADH 331
            G+  ++  L +  NQL  +P+ + GL+S+E L  S N ++ LP  +G L  LR    + 
Sbjct: 398 FGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEE 457

Query: 332 NYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQ 391
           N L+ LP EI   K++  L L +N+L TLP  +G +  L  + L +N L +LP     L+
Sbjct: 458 NKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLE 517

Query: 392 QLTAMWLSDNQSKPLIPLQKETDSETQKMVLTN 424
            L  ++L+DN +   +P +    S+   M + N
Sbjct: 518 NLEELYLNDNPNLHSLPFELALCSKLSIMSIEN 550



 Score =  177 bits (450), Expect = 5e-44
 Identities = 115/385 (29%), Positives = 195/385 (50%), Gaps = 28/385 (7%)

Query: 27  LDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPA 86
           LD  H  L ++P  ++  + +L  LYL  N+I  + K + N   L  LS+ +N +  LPA
Sbjct: 174 LDLRHNKLREIPSVVYRLD-SLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLPA 232

Query: 87  SIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLN 146
            I  L NL  LDV+ N ++  P+ I NC  +T ++   N +  LPD    L +L++L L 
Sbjct: 233 EIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLSRLGLR 292

Query: 147 DAFLEFLPANFGRLTKLQILELRENQLKMLPKTM-NRLTQLERLDLGSNEFTEVPE---- 201
              L  +P +  + + L+ L L  N +  LP+++ + L +L  L L  N F   P     
Sbjct: 293 YNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPS 352

Query: 202 ---------------------VLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN 240
                                +  +   L +  M  N+LT +P   G+   +  L+++ N
Sbjct: 353 QFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATN 412

Query: 241 NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLIS 300
            +  + E +S   +L+ L+LS+N L++LP  +G+L+ +  L ++EN+L  LP+ I  L  
Sbjct: 413 QLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKD 472

Query: 301 VEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSN-KLET 359
           +++L  + N++  LP  IG LTNL       N L  LP EIG+ +N+  L+L+ N  L +
Sbjct: 473 LQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHS 532

Query: 360 LPEEMGDMQKLKVINLSDNRLKNLP 384
           LP E+    KL ++++ +  L +LP
Sbjct: 533 LPFELALCSKLSIMSIENCPLSHLP 557



 Score =  159 bits (403), Expect = 1e-38
 Identities = 114/389 (29%), Positives = 182/389 (46%), Gaps = 50/389 (12%)

Query: 93  NLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEF 152
           N   LD+SK  I   P +IK    LT +    N +  LP     L+NL  L L++  L  
Sbjct: 101 NSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTS 160

Query: 153 LPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEF 212
           LP +   L KL++L+LR N+L+ +P  + RL  L  L L  N  T V + ++ LS L   
Sbjct: 161 LPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSML 220

Query: 213 WMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETI 272
            +  N++  +P  IG L  L  LDV+ N +E + + I  C  + +L L  N L  LP+TI
Sbjct: 221 SIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTI 280

Query: 273 GSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSI-------------- 318
           G+L +++ L +  N+L  +P S+    ++EEL+   N +  LP S+              
Sbjct: 281 GNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLAR 340

Query: 319 -----------GQLTNLRTFAADH------------------------NYLQQLPPEIGS 343
                       Q + + +   +H                        N L  LP + G+
Sbjct: 341 NCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGT 400

Query: 344 WKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQS 403
           W ++  L L +N+L  +PE++  +  L+V+ LS+N LK LP     L++L  + L +N+ 
Sbjct: 401 WTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKL 460

Query: 404 KPLIPLQKETDSETQKMVLTNYMFPQQPR 432
           + L P +     + QK+VLTN      PR
Sbjct: 461 ESL-PNEIAYLKDLQKLVLTNNQLTTLPR 488



 Score =  154 bits (388), Expect = 7e-37
 Identities = 106/327 (32%), Positives = 172/327 (52%), Gaps = 5/327 (1%)

Query: 19  GEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPD 78
           GE   + TLD +H  LE +PKEI    + +  L L  N++ +LP  + N  SL +L L  
Sbjct: 235 GELCNLITLDVAHNQLEHLPKEIGNCTQ-ITNLDLQHNELLDLPDTIGNLSSLSRLGLRY 293

Query: 79  NDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKV-LTIVEASVNPISKLP-DGFSQ 136
           N L+ +P S+A    L EL++  N I   PE++ +  V L  +  + N     P  G SQ
Sbjct: 294 NRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQ 353

Query: 137 LLNLTQLYLNDAFLEFLPAN-FGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNE 195
              +  L +    +  +P   F R   L  L +++NQL  LP      T +  L+L +N+
Sbjct: 354 FSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQ 413

Query: 196 FTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENL 255
            T++PE +  L  L+   +  N L  +P  +G+L++L  LD+ +N +E +   I+  ++L
Sbjct: 414 LTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDL 473

Query: 256 QDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFN-EVEAL 314
           Q L+L++N L  LP  IG L N+T L + EN L +LP+ IG L ++EEL  + N  + +L
Sbjct: 474 QKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSL 533

Query: 315 PSSIGQLTNLRTFAADHNYLQQLPPEI 341
           P  +   + L   + ++  L  LPP+I
Sbjct: 534 PFELALCSKLSIMSIENCPLSHLPPQI 560



 Score =  146 bits (368), Expect = 2e-34
 Identities = 101/322 (31%), Positives = 162/322 (50%), Gaps = 10/322 (3%)

Query: 120 VEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKT 179
           ++ S   I  LP    +L  LT+LYL    L+ LPA  G L  L  L L EN L  LP +
Sbjct: 105 LDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDS 164

Query: 180 MNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSK 239
           ++ L +L  LDL  N+  E+P V+ +L  L   ++  NR+T +   I +L +L+ L + +
Sbjct: 165 LDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRE 224

Query: 240 NNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLI 299
           N I+ +   I    NL  L ++ N L+ LP+ IG+   IT L +  N+L+ LPD+IG L 
Sbjct: 225 NKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLS 284

Query: 300 SVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPE-IGSWKNITVLFLHSNKLE 358
           S+  L   +N + A+P S+ + + L     ++N +  LP   + S   +  L L  N  +
Sbjct: 285 SLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQ 344

Query: 359 TLPEEMGDMQKLKVI---NLSDNRLKNLPFS-FTKLQQLTAMWLSDNQSKPLIPLQKETD 414
             P  +G   +   I   N+  NR+  +PF  F++ + L+ + + DNQ   L PL   T 
Sbjct: 345 LYP--VGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSL-PLDFGTW 401

Query: 415 SETQKMVLTNYMFPQQPRTEDV 436
           +   ++ L      + P  EDV
Sbjct: 402 TSMVELNLATNQLTKIP--EDV 421


>gi|122937315 leucine-rich repeats and IQ motif containing 4 [Homo
           sapiens]
          Length = 560

 Score =  173 bits (439), Expect = 9e-43
 Identities = 118/420 (28%), Positives = 206/420 (49%), Gaps = 12/420 (2%)

Query: 23  TVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLF-NCQSLHKLSLPDNDL 81
           ++ +LD S+  +      + +F   L EL L    ++E+P  +F N   L  L L  N L
Sbjct: 95  SLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHL 154

Query: 82  TTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLT 141
             LP  I N   LRE+ + +N  + FP+ +     L I++   N I  +P+    L  L 
Sbjct: 155 KCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGHLTGLQ 214

Query: 142 QLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPE 201
           + Y+    L  LPA+  + ++L +L+L  N L  +PK+   L ++  + L  N   +VP 
Sbjct: 215 KFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPR 274

Query: 202 VLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLS 261
           ++ + + L   ++    L  + G    L  L +LD+S+N++      I   +NL+ L L 
Sbjct: 275 LICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLD 334

Query: 262 SNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEEL----DCSFNEVEALPSS 317
            N + QLP  +GSL  +  L +  N+ +  P+ +  L S+E+L    D  F ++  +P  
Sbjct: 335 DNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGF-KLTYVPEH 393

Query: 318 IGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSD 377
           I +L +L+    ++N+L+ LP  +GS  N+ VL    N L+ LP+ +   Q LK + L D
Sbjct: 394 IRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLED 453

Query: 378 NRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQPRTEDVM 437
           N L +LP +   L  L  + L DN   P+    KE  +E  + +   + + ++ R  ++M
Sbjct: 454 NLLTHLPENLDSLVNLKVLTLMDN---PMEEPPKEVCAEGNEAI---WKYLKENRNRNIM 507



 Score =  165 bits (417), Expect = 3e-40
 Identities = 114/382 (29%), Positives = 196/382 (51%), Gaps = 10/382 (2%)

Query: 27  LDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPA 86
           +D S+ SL  +P EIFTF + LEE++L+ NQIEE+P+++   +++  L L  N+L +L  
Sbjct: 30  IDASNQSLTAIPLEIFTFTE-LEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCP 88

Query: 87  SIANLINLRELDVSKNGIQEFPENIKN----CKVLTIVEASVNPISKLPDGFSQLLNLTQ 142
           ++  L +L  LD+S N I      + +     + L + +  +  I  +   F  L +L  
Sbjct: 89  ALGLLSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVI--FKNLHHLEL 146

Query: 143 LYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEV 202
           L L    L+ LP      TKL+ + L+ NQ ++ P+ +  L  LE +DL  N+   +PE 
Sbjct: 147 LGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEE 206

Query: 203 LEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSS 262
           +  L+GL++F+M +N L  +P  +    QL+ LD+S N +  + +  +    + ++ LS 
Sbjct: 207 IGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSG 266

Query: 263 NSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLT 322
           N L+++P  I    ++  L +    L  L  S   L+++  LD S N +   P  I  L 
Sbjct: 267 NRLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALK 326

Query: 323 NLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEE---MGDMQKLKVINLSDNR 379
           NL     D N + QLP E+GS   + +L L  N+  + PEE   +  ++KL +      +
Sbjct: 327 NLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFK 386

Query: 380 LKNLPFSFTKLQQLTAMWLSDN 401
           L  +P    KLQ L  +++ +N
Sbjct: 387 LTYVPEHIRKLQSLKELYIENN 408



 Score =  158 bits (400), Expect = 3e-38
 Identities = 108/362 (29%), Positives = 182/362 (50%), Gaps = 7/362 (1%)

Query: 34  LEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLIN 93
           L+ +PKEI    K L E+YL  NQ E  P++L    +L  + L +N +  +P  I +L  
Sbjct: 154 LKCLPKEIVNQTK-LREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGHLTG 212

Query: 94  LRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFL 153
           L++  ++ N +   P ++  C  L++++ S N +  +P  F++L  +T++ L+   LE +
Sbjct: 213 LQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKV 272

Query: 154 PANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFW 213
           P    R T L +L L    L  L  +   L  L  LDL  N     P  +  L  L+   
Sbjct: 273 PRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLG 332

Query: 214 MDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNS---LQQLPE 270
           +D N++  +P  +GSL +L  L ++ N      E + +  +L+ L +  +    L  +PE
Sbjct: 333 LDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPE 392

Query: 271 TIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAAD 330
            I  L+++  L I+ N L YLP S+G + ++E LDC  N ++ LP +I Q   L+    +
Sbjct: 393 HIRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLE 452

Query: 331 HNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEM-GDMQKLKVINLSDNRLKNLPFSFTK 389
            N L  LP  + S  N+ VL L  N +E  P+E+  +  +     L +NR +N+    TK
Sbjct: 453 DNLLTHLPENLDSLVNLKVLTLMDNPMEEPPKEVCAEGNEAIWKYLKENRNRNI--MATK 510

Query: 390 LQ 391
           +Q
Sbjct: 511 IQ 512


>gi|238908508 leucine-rich repeat and death domain-containing
           protein [Homo sapiens]
          Length = 860

 Score =  170 bits (431), Expect = 8e-42
 Identities = 118/396 (29%), Positives = 188/396 (47%), Gaps = 27/396 (6%)

Query: 24  VTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTT 83
           +  L  +   LE +  +I  F + L  L LD N ++ +P+++  C  L  LSL DN LT 
Sbjct: 351 IKELQLADNKLEVISHKIENFRE-LRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTE 409

Query: 84  LPASIANLINLRELDVSKNG-----------------------IQEFPENIKNCKVLTIV 120
           LP  I  L NLR+L V++N                        I + P  IKNC+ +  +
Sbjct: 410 LPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKI 469

Query: 121 EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM 180
           E S N I   P G   L +L  L +N  ++  +P +     +L  LEL EN+L +  +  
Sbjct: 470 ELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHF 529

Query: 181 NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN 240
             L  L+ LDLG N+  ++P  +  +  L    +  N+    P  + +L+ L  LD+S+N
Sbjct: 530 CSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSEN 589

Query: 241 NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDE---NQLMYLPDSIGG 297
            ++ +   I   + +Q L  SSN     P  +  L+++  L I +    +L  LP  +  
Sbjct: 590 QLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSN 649

Query: 298 LISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKL 357
           +  ++ELD S N +  +P +IG+L NL +  A +N +  LPP + S  ++  L L  N L
Sbjct: 650 MTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNL 709

Query: 358 ETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQL 393
             LP  + ++  LK IN  DN L   P    K +QL
Sbjct: 710 TALPSAIYNIFSLKEINFDDNPLLRPPVEICKGKQL 745



 Score =  154 bits (389), Expect = 6e-37
 Identities = 108/399 (27%), Positives = 190/399 (47%), Gaps = 24/399 (6%)

Query: 27  LDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPA 86
           L+ SH  +  +PKEI      + +L+   N IE  P  L    +L  LSL  N L  +P 
Sbjct: 216 LNVSHNHISHIPKEISQLGN-IRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRHIPD 274

Query: 87  SIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLN 146
           ++ +L  LR L++  N +  FP+ +     L  ++ + N IS LP    +L NL  L ++
Sbjct: 275 TLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMD 334

Query: 147 DAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQL 206
              L FL     +L K++ L+L +N+L+++   +    +L  L L  N    +PE +   
Sbjct: 335 HNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCC 394

Query: 207 SGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQ 266
           + L+   +  N+LT +P +I  L  L  L V++NN+  + + IS   N+  L  S N + 
Sbjct: 395 AMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIIT 454

Query: 267 QLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIG------- 319
            +P  I + + I  +++  N++MY P  +  L S+  L  + N +  +P  I        
Sbjct: 455 DVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLH 514

Query: 320 ----------------QLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEE 363
                            L NL+      N ++++P  I +  ++ VL L  NK ET P E
Sbjct: 515 LELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRE 574

Query: 364 MGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQ 402
           +  ++ L+V++LS+N+L+ +      L+ +  +  S NQ
Sbjct: 575 LCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQ 613



 Score =  150 bits (378), Expect = 1e-35
 Identities = 119/424 (28%), Positives = 193/424 (45%), Gaps = 48/424 (11%)

Query: 26  TLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELP-KQLFNCQSLHKLSLPDNDLTTL 84
           T++     L++ PK+I    K ++ LYLD NQI+        +   L  LSL +N L++L
Sbjct: 145 TVNLEAKGLQEFPKDILKI-KYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSL 203

Query: 85  PASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLY 144
           P+ I  L NLR L+VS N I   P+ I     +  +    N I   P     L NL  L 
Sbjct: 204 PSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILS 263

Query: 145 LNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLE 204
           L    L  +P     L  L++L L  NQL   PK +  L +L  LDL  N  + +P+ + 
Sbjct: 264 LGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIR 323

Query: 205 QLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVE------------------ 246
           +L  L+   MD N+LTF+   I  L ++  L ++ N +E++                   
Sbjct: 324 ELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNL 383

Query: 247 -----EGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSI------ 295
                E IS C  L+ L LS N L +LP+ I  L N+  L ++ N ++ + D I      
Sbjct: 384 LKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNI 443

Query: 296 ------GGLIS-----------VEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLP 338
                 G +I+           + +++ S+N++   P  +  L +L   + + NY+ ++P
Sbjct: 444 CSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIP 503

Query: 339 PEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWL 398
            +I   K +  L L  NKL    E    +  LK ++L  N++K +P S + +  L  + L
Sbjct: 504 VDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLIL 563

Query: 399 SDNQ 402
             N+
Sbjct: 564 CCNK 567


>gi|110825984 malignant fibrous histiocytoma amplified sequence 1
           [Homo sapiens]
          Length = 1052

 Score =  150 bits (380), Expect = 6e-36
 Identities = 100/292 (34%), Positives = 146/292 (50%), Gaps = 2/292 (0%)

Query: 1   MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEE 60
           +  +R+ F RL P     G    +T LD SH  L  +  E+ +  + L +L L  NQ+  
Sbjct: 92  LVLRRNRFARLPPAVAELGHH--LTELDVSHNRLTALGAEVVSALRELRKLNLSHNQLPA 149

Query: 61  LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIV 120
           LP QL     L +L +  N L  LP S++ L  LR LDV  N +  FP  +     L  +
Sbjct: 150 LPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEEL 209

Query: 121 EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM 180
           + S N +  LP+  S L  L  L+L+ A L  LPA F  L  L+ L L  N L+ LP   
Sbjct: 210 DVSSNRLRGLPEDISALRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQF 269

Query: 181 NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN 240
           + L +L+ L+L SN F E P  L  L+GL+E ++  N+LT +P  I  L +L  L +  N
Sbjct: 270 SCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNN 329

Query: 241 NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLP 292
            I  + + I     L++L+L  N +  LP+  G L  +   KI +N L+  P
Sbjct: 330 RIRYLPDSIVELTGLEELVLQGNQIAVLPDHFGQLSRVGLWKIKDNPLIQPP 381



 Score =  137 bits (344), Expect = 9e-32
 Identities = 106/340 (31%), Positives = 164/340 (48%), Gaps = 24/340 (7%)

Query: 48  LEELYLDANQIEELPKQLFNCQ-SLHKLSLPDNDLTTLPASIANL-INLRELDVSKNGIQ 105
           +E L L  N +EE+P+ L +   SL  L L  N    LP ++A L  +L ELDVS N   
Sbjct: 65  IEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNR-- 122

Query: 106 EFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQI 165
                      LT + A V          S L  L +L L+   L  LPA  G L  L+ 
Sbjct: 123 -----------LTALGAEV---------VSALRELRKLNLSHNQLPALPAQLGALAHLEE 162

Query: 166 LELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGF 225
           L++  N+L  LP +++ L++L  LD+  N+ T  P  L QL  L+E  + +NRL  +P  
Sbjct: 163 LDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPED 222

Query: 226 IGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDE 285
           I +L+ L  L +S   +  +  G     +L+ L+L +N LQ LP     L+ +  L +  
Sbjct: 223 ISALRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSS 282

Query: 286 NQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWK 345
           N     P ++  L  +EEL  S N++ ++PS I  L  L T   D+N ++ LP  I    
Sbjct: 283 NLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELT 342

Query: 346 NITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPF 385
            +  L L  N++  LP+  G + ++ +  + DN L   P+
Sbjct: 343 GLEELVLQGNQIAVLPDHFGQLSRVGLWKIKDNPLIQPPY 382



 Score =  134 bits (337), Expect = 6e-31
 Identities = 95/320 (29%), Positives = 156/320 (48%), Gaps = 2/320 (0%)

Query: 24  VTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNC-QSLHKLSLPDNDLT 82
           +  L+  +  LE+VP+ + +   +L  L L  N+   LP  +      L +L +  N LT
Sbjct: 65  IEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLT 124

Query: 83  TLPASIANLIN-LRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLT 141
            L A + + +  LR+L++S N +   P  +     L  ++ S N ++ LPD  S L  L 
Sbjct: 125 ALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLR 184

Query: 142 QLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPE 201
            L ++   L   P    +L  L+ L++  N+L+ LP+ ++ L  L+ L L   E   +P 
Sbjct: 185 TLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPA 244

Query: 202 VLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLS 261
              +L+ L+   +D N L  +P     L++L  L++S N  E     +     L++L LS
Sbjct: 245 GFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLS 304

Query: 262 SNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQL 321
            N L  +P  I  L  + TL +D N++ YLPDSI  L  +EEL    N++  LP   GQL
Sbjct: 305 RNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDHFGQL 364

Query: 322 TNLRTFAADHNYLQQLPPEI 341
           + +  +    N L Q P E+
Sbjct: 365 SRVGLWKIKDNPLIQPPYEV 384



 Score =  129 bits (324), Expect = 2e-29
 Identities = 102/337 (30%), Positives = 162/337 (48%), Gaps = 9/337 (2%)

Query: 74  LSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCK-VLTIVEASVNPISKLPD 132
           L  P +    LPA   NL ++  L++  NG++E PE + +    L ++    N  ++LP 
Sbjct: 48  LESPASPQLVLPA---NLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPP 104

Query: 133 GFSQL-LNLTQLYLNDAFLEFLPANF-GRLTKLQILELRENQLKMLPKTMNRLTQLERLD 190
             ++L  +LT+L ++   L  L A     L +L+ L L  NQL  LP  +  L  LE LD
Sbjct: 105 AVAELGHHLTELDVSHNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELD 164

Query: 191 LGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGIS 250
           +  N    +P+ L  LS L+   +D N+LT  P  +  L  L  LDVS N +  + E IS
Sbjct: 165 VSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDIS 224

Query: 251 TCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNE 310
               L+ L LS   L  LP     L ++ +L +D N L  LP     L  ++ L+ S N 
Sbjct: 225 ALRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNL 284

Query: 311 VEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKL 370
            E  P+++  L  L       N L  +P  I     +  L+L +N++  LP+ + ++  L
Sbjct: 285 FEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGL 344

Query: 371 KVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLI 407
           + + L  N++  LP  F +L ++    + DN   PLI
Sbjct: 345 EELVLQGNQIAVLPDHFGQLSRVGLWKIKDN---PLI 378


>gi|21361633 leucine rich repeat containing 40 [Homo sapiens]
          Length = 602

 Score =  149 bits (375), Expect = 2e-35
 Identities = 118/377 (31%), Positives = 187/377 (49%), Gaps = 46/377 (12%)

Query: 48  LEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEF 107
           L +L +  N+++ L   L    +L  L + DN LT+LP++I  L NL++L+VS N ++  
Sbjct: 84  LTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKIL 143

Query: 108 PENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILE 167
           PE I N + L  +    N ++ + +GF QL NL  L L++  L  +PA+F  L+ L  L 
Sbjct: 144 PEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLN 203

Query: 168 LRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIG 227
           L  N+LK LP  +NR+ +L+ LD  SN    +P  L  +  L+  ++  N+L F+P F  
Sbjct: 204 LSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPEF-P 262

Query: 228 SLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQ 287
           S   L  L V +N IEM+E                       E +  L +I  L + +N+
Sbjct: 263 SCSLLKELHVGENQIEMLE----------------------AEHLKHLNSILVLDLRDNK 300

Query: 288 LMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNI 347
           L  +PD I  L S+E LD S N++ +LP S+G L +L+  A + N L+ +  EI S    
Sbjct: 301 LKSVPDEIILLRSLERLDLSNNDISSLPYSLGNL-HLKFLALEGNPLRTIRREIISKGTQ 359

Query: 348 TVLFLHSNKLE---------------TLPEE----MGDMQKLKVINLSDNRLKNLP---F 385
            VL    +K++               TLP E    +  +  LK+++ SD +   +P   F
Sbjct: 360 EVLKYLRSKIKDDGPSQSESATETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVF 419

Query: 386 SFTKLQQLTAMWLSDNQ 402
              K   +T++  S NQ
Sbjct: 420 DAVKSNIVTSINFSKNQ 436



 Score =  132 bits (332), Expect = 2e-30
 Identities = 122/442 (27%), Positives = 208/442 (47%), Gaps = 39/442 (8%)

Query: 20  EEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDN 79
           E E +  L+ SH  L+ +P+EI T  + L+ LYL  N++  + +      +L  L L +N
Sbjct: 126 ELENLQKLNVSHNKLKILPEEI-TNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNN 184

Query: 80  DLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLN 139
            LTT+PAS ++L +L  L++S N ++  P  I   K L  ++ + N +  +P   + + +
Sbjct: 185 HLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMES 244

Query: 140 LTQLYLNDAFLEFLPA-----------------------NFGRLTKLQILELRENQLKML 176
           L  LYL    L FLP                        +   L  + +L+LR+N+LK +
Sbjct: 245 LELLYLRRNKLRFLPEFPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSV 304

Query: 177 PKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLD 236
           P  +  L  LERLDL +N+ + +P  L  L  LK   ++ N L  I   I S      L 
Sbjct: 305 PDEIILLRSLERLDLSNNDISSLPYSLGNLH-LKFLALEGNPLRTIRREIISKGTQEVLK 363

Query: 237 VSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKI---DENQLMYLPD 293
             ++ I+  ++G S  E+  +  ++  S     E+  ++  I TLKI    + Q   +PD
Sbjct: 364 YLRSKIK--DDGPSQSESATETAMTLPS-----ESRVNIHAIITLKILDYSDKQATLIPD 416

Query: 294 SIGGLIS---VEELDCSFNEVEALPSSIGQLTNLRTFA-ADHNYLQQLPPEIGSWKNITV 349
            +   +    V  ++ S N++  +P  + +L  + +      N L  +  E+   + +T 
Sbjct: 417 EVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTF 476

Query: 350 LFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPL 409
           L L +N L +LPEEM  + +L+ INLS NR K LP    ++  L  + +S+NQ   + P 
Sbjct: 477 LDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQ 536

Query: 410 QKETDSETQKMVLTNYMFPQQP 431
           + +       + L N    Q P
Sbjct: 537 KMKMMENLTTLDLQNNDLLQIP 558



 Score =  125 bits (313), Expect = 4e-28
 Identities = 94/328 (28%), Positives = 166/328 (50%), Gaps = 6/328 (1%)

Query: 96  ELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPA 155
           +L++S   + E P+ +    V    EA+ N      + + +  +LT+L +++  L+ L  
Sbjct: 40  QLNLSGRNLSEVPQCVWRINVDIPEEANQNLSFGATERWWEQTDLTKLIISNNKLQSLTD 99

Query: 156 NFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMD 215
           +   L  L +L++ +NQL  LP  +  L  L++L++  N+   +PE +  L  LK  ++ 
Sbjct: 100 DLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPEEITNLRNLKCLYLQ 159

Query: 216 ANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSL 275
            N LT I      L  L  LD+S N++  V    S+  +L  L LSSN L+ LP  I  +
Sbjct: 160 HNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRM 219

Query: 276 KNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQ 335
           K +  L  + N L  +P  + G+ S+E L    N++  LP      + L+      N ++
Sbjct: 220 KRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLP-EFPSCSLLKELHVGENQIE 278

Query: 336 QLPPE-IGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLT 394
            L  E +    +I VL L  NKL+++P+E+  ++ L+ ++LS+N + +LP+S   L  L 
Sbjct: 279 MLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNL-HLK 337

Query: 395 AMWLSDNQSKPLIPLQKETDSETQKMVL 422
            + L  N   PL  +++E  S+  + VL
Sbjct: 338 FLALEGN---PLRTIRREIISKGTQEVL 362



 Score = 97.8 bits (242), Expect = 6e-20
 Identities = 96/381 (25%), Positives = 175/381 (45%), Gaps = 28/381 (7%)

Query: 23  TVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLT 82
           ++  L+ S   L+ +P EI    K L+ L  ++N +E +P +L   +SL  L L  N L 
Sbjct: 198 SLVRLNLSSNELKSLPAEINRM-KRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLR 256

Query: 83  TLPASIANLINLRELDVSKNGIQEFP-ENIKNCKVLTIVEASVNPISKLPDGFSQLLNLT 141
            LP    +   L+EL V +N I+    E++K+   + +++   N +  +PD    L +L 
Sbjct: 257 FLP-EFPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLE 315

Query: 142 QLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERL--------DLGS 193
           +L L++  +  LP + G L  L+ L L  N L+ + + +      E L        D G 
Sbjct: 316 RLDLSNNDISSLPYSLGNL-HLKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGP 374

Query: 194 NEFTEVPEVLEQLSG-----------LKEFWMDANRLTFIPGFIGSLKQ---LTYLDVSK 239
           ++     E    L             LK       + T IP  +    +   +T ++ SK
Sbjct: 375 SQSESATETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSK 434

Query: 240 NNI-EMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGL 298
           N + E+ +  +   E + D+ LS N L  +   +  L+ +T L +  N L  LP+ +  L
Sbjct: 435 NQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESL 494

Query: 299 ISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPE-IGSWKNITVLFLHSNKL 357
           + ++ ++ SFN  + LP  + ++  L T    +N +  + P+ +   +N+T L L +N L
Sbjct: 495 VRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDL 554

Query: 358 ETLPEEMGDMQKLKVINLSDN 378
             +P E+G+   L+ + L  N
Sbjct: 555 LQIPPELGNCVNLRTLLLDGN 575



 Score = 41.2 bits (95), Expect = 0.007
 Identities = 26/106 (24%), Positives = 54/106 (50%), Gaps = 2/106 (1%)

Query: 22  ETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDL 81
           + +T LD  +  L  +P+E+ +  + L+ + L  N+ + LP+ L+   +L  + + +N +
Sbjct: 472 QKLTFLDLRNNFLNSLPEEMESLVR-LQTINLSFNRFKMLPEVLYRIFTLETILISNNQV 530

Query: 82  TTL-PASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNP 126
            ++ P  +  + NL  LD+  N + + P  + NC  L  +    NP
Sbjct: 531 GSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGNP 576


>gi|4503743 flightless I homolog [Homo sapiens]
          Length = 1269

 Score =  139 bits (350), Expect = 2e-32
 Identities = 102/340 (30%), Positives = 178/340 (52%), Gaps = 8/340 (2%)

Query: 47  TLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQE 106
           +L  L L+   +  LP++L   Q L  LS+  N+LTTL   +++L +LR +    N ++ 
Sbjct: 34  SLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRAIVARANSLKN 93

Query: 107 --FPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPAN-FGRLTKL 163
              P++I     L++++ S N +++ P       N+  L L+   ++ +P   F  LT L
Sbjct: 94  SGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDL 153

Query: 164 QILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVP-EVLEQLSGLKEFWMDANRLT-- 220
             L+L EN+L+ LP  M RL  L+ L L  N         L  ++ L+   + + + T  
Sbjct: 154 LYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQS 213

Query: 221 FIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITT 280
            +P  +  L  L  +D+S N++  V E + T  +L+ L LSSN + +L   I    ++ T
Sbjct: 214 NLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVET 273

Query: 281 LKIDENQLMYLPDSIGGLISVEELDCSFNEV--EALPSSIGQLTNLRTFAADHNYLQQLP 338
           L +  NQL  LP +I  L  +++L  + N++  + LPS IG+LTNL  F A +N L+ +P
Sbjct: 274 LNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVP 333

Query: 339 PEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDN 378
             +     +  L L+ N L TLPE +  + +++V+++ +N
Sbjct: 334 ESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVREN 373



 Score =  131 bits (329), Expect = 5e-30
 Identities = 110/352 (31%), Positives = 168/352 (47%), Gaps = 17/352 (4%)

Query: 27  LDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTT--L 84
           L  +   L  +P+E+   +K LE L +  N +  L  +L +  SL  +    N L    +
Sbjct: 38  LKLNRTGLCYLPEELAALQK-LEHLSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGV 96

Query: 85  PASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDG-FSQLLNLTQL 143
           P  I  L +L  LD+S N + E P  ++N K + ++  S N I  +P+  F  L +L  L
Sbjct: 97  PDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYL 156

Query: 144 YLNDAFLEFLPANFGRLTKLQILELREN-----QLKMLPKTMNRLTQLERLDLGSNEFTE 198
            L++  LE LP    RL  LQ L L  N     QL+ LP     +T L+ L L S + T+
Sbjct: 157 DLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPA----MTALQTLHLRSTQRTQ 212

Query: 199 --VPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQ 256
             +P  LE LS L +  +  N LT +P  + +L  L  L++S N I  +   I    +++
Sbjct: 213 SNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVE 272

Query: 257 DLLLSSNSLQQLPETIGSLKNITTLKIDENQLMY--LPDSIGGLISVEELDCSFNEVEAL 314
            L LS N L  LP  I  L  +  L ++ N+L +  LP  IG L ++EE   + N +E +
Sbjct: 273 TLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELV 332

Query: 315 PSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGD 366
           P S+ +   LR    + N+L  LP  I     I VL +  N    +P +  D
Sbjct: 333 PESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLVMPPKPAD 384



 Score =  119 bits (297), Expect = 3e-26
 Identities = 84/279 (30%), Positives = 140/279 (50%), Gaps = 11/279 (3%)

Query: 22  ETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLF-NCQSLHKLSLPDND 80
           + ++ LD SH  L + P+E+    K +  L L  N I+ +P QLF N   L  L L +N 
Sbjct: 104 DDLSVLDLSHNQLTECPRELEN-AKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENR 162

Query: 81  LTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVE-----ASVNPISKLPDGFS 135
           L +LP  +  L++L+ L ++ N +      ++    +T ++     ++    S LP    
Sbjct: 163 LESLPPQMRRLVHLQTLVLNGNPLLH--AQLRQLPAMTALQTLHLRSTQRTQSNLPTSLE 220

Query: 136 QLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNE 195
            L NL  + L+   L  +P     L  L+ L L  NQ+  L   +++   +E L+L  N+
Sbjct: 221 GLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQ 280

Query: 196 FTEVPEVLEQLSGLKEFWMDANRLTF--IPGFIGSLKQLTYLDVSKNNIEMVEEGISTCE 253
            T +P  + +LS LK+ ++++N+L F  +P  IG L  L     + NN+E+V E +  C 
Sbjct: 281 LTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCP 340

Query: 254 NLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLP 292
            L+ L+L+ N L  LPE I  L  I  L + EN  + +P
Sbjct: 341 KLRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLVMP 379



 Score =  115 bits (287), Expect = 4e-25
 Identities = 106/375 (28%), Positives = 176/375 (46%), Gaps = 27/375 (7%)

Query: 94  LRELDVSKNGIQE--FPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLE 151
           +R +D+S N  +   FPEN+K    L  ++ +   +  LP+  + L  L  L ++   L 
Sbjct: 10  VRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLT 69

Query: 152 FLPANFGRLTKLQILELRENQLKM--LPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGL 209
            L      L  L+ +  R N LK   +P  + +L  L  LDL  N+ TE P  LE    +
Sbjct: 70  TLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNM 129

Query: 210 KEFWMDANRLTFIPG--FIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSN---- 263
               +  N +  IP   FI +L  L YLD+S+N +E +   +    +LQ L+L+ N    
Sbjct: 130 LVLNLSHNSIDTIPNQLFI-NLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLH 188

Query: 264 -SLQQLPETIGSLKNITTLKIDENQLMY--LPDSIGGLISVEELDCSFNEVEALPSSIGQ 320
             L+QLP    ++  + TL +   Q     LP S+ GL ++ ++D S N++  +P  +  
Sbjct: 189 AQLRQLP----AMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYT 244

Query: 321 LTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRL 380
           L +LR      N + +L   I  W ++  L L  N+L +LP  +  + KLK + L+ N+L
Sbjct: 245 LPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKL 304

Query: 381 --KNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQPRTEDVMF 438
               LP    KL  L   +++ N +  L+P       + +K+VL        P  E + F
Sbjct: 305 DFDGLPSGIGKLTNLEE-FMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLP--EAIHF 361

Query: 439 ISDNESF----NPSL 449
           +++ E      NP+L
Sbjct: 362 LTEIEVLDVRENPNL 376


>gi|65301141 PH domain and leucine rich repeat protein
           phosphatase-like [Homo sapiens]
          Length = 1323

 Score =  124 bits (310), Expect = 8e-28
 Identities = 114/376 (30%), Positives = 188/376 (50%), Gaps = 31/376 (8%)

Query: 47  TLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQE 106
           TL EL L  N   +LP Q+ N  +L  L L  N LTTLP  + NL  L  L +S N   +
Sbjct: 323 TLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEELGNLQQLSSLGISFNNFSQ 382

Query: 107 FPENIKNCKVLTIVEASVNPISKLPDGFSQLLN------LTQLYLNDAFLEFLPANFGRL 160
            PE  +   +L  V  + N +  L  G    +N      L   +L    +E L  N    
Sbjct: 383 IPEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLKTMVIENLEGN---- 438

Query: 161 TKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSG--LKEFWMDANR 218
             +  ++LR+N+L  L   ++ L  LE+L  G N+  E+      LSG  L+  +  +NR
Sbjct: 439 KHITHVDLRDNRLTDL--DLSSLCSLEQLHCGRNQLREL-----TLSGFSLRTLYASSNR 491

Query: 219 LTFIPGF-IGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKN 277
           LT +  + + SL  LT+LD+S+N +E V +     + ++ L +S N L ++P  I S  +
Sbjct: 492 LTAVNVYPVPSL--LTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEVPVRILSSLS 549

Query: 278 ITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSI-GQLTNLRTFAADHNYLQQ 336
           +  L +  N +  LP  +   I +E LD   N +  LP ++  +  NLR   A  N L+ 
Sbjct: 550 LRKLMLGHNHVQNLPTLVEH-IPLEVLDLQHNALTRLPDTLFSKALNLRYLNASANSLES 608

Query: 337 LPPEIGSWKNIT---VLFLHSNKL--ETLPEEMGDMQKLKVINLSDNRLKNLPFS-FTKL 390
           LP      ++++   +L+L +N L  + +P  +G +  L++++L++N+L+  P S   KL
Sbjct: 609 LPSACTGEESLSMLQLLYLTNNLLTDQCIPVLVGHLH-LRILHLANNQLQTFPASKLNKL 667

Query: 391 QQLTAMWLSDNQSKPL 406
           +QL  + LS N+ K +
Sbjct: 668 EQLEELNLSGNKLKTI 683



 Score =  107 bits (268), Expect = 6e-23
 Identities = 102/378 (26%), Positives = 170/378 (44%), Gaps = 32/378 (8%)

Query: 53  LDANQIEELPKQLFNCQSLHKLSLPDNDLTT-LPASIANLIN---LRELDVSKNGIQEFP 108
           L    +EE+P+ LF  Q +  L+L  N +    P  +  L     L+ L++S N +  FP
Sbjct: 256 LSCYSLEEVPEHLFYSQDITYLNLRHNFMQLERPGGLDTLYKFSQLKGLNLSHNKLGLFP 315

Query: 109 ENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILEL 168
             +     LT +  S N    LP     LLNL  L L+  FL  LP   G L +L  L +
Sbjct: 316 ILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEELGNLQQLSSLGI 375

Query: 169 RENQLKMLPKTMNRLTQLERLDLGSNEFTEVP-EVLEQLSGLKEFWMDANRL-TFIPGFI 226
             N    +P+   +LT L+R+ +  N    +   VL +++ +K   +  N L T +   +
Sbjct: 376 SFNNFSQIPEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLKTMVIENL 435

Query: 227 GSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKN--------- 277
              K +T++D+  N +  ++  +S+  +L+ L    N L++L  +  SL+          
Sbjct: 436 EGNKHITHVDLRDNRLTDLD--LSSLCSLEQLHCGRNQLRELTLSGFSLRTLYASSNRLT 493

Query: 278 ----------ITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTF 327
                     +T L +  N L  +PD       +E LD S+N +  +P  I    +LR  
Sbjct: 494 AVNVYPVPSLLTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEVPVRILSSLSLRKL 553

Query: 328 AADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEM-GDMQKLKVINLSDNRLKNLPFS 386
              HN++Q LP  +     + VL L  N L  LP+ +      L+ +N S N L++LP +
Sbjct: 554 MLGHNHVQNLPTLV-EHIPLEVLDLQHNALTRLPDTLFSKALNLRYLNASANSLESLPSA 612

Query: 387 FT---KLQQLTAMWLSDN 401
            T    L  L  ++L++N
Sbjct: 613 CTGEESLSMLQLLYLTNN 630



 Score = 98.6 bits (244), Expect = 4e-20
 Identities = 85/273 (31%), Positives = 135/273 (49%), Gaps = 12/273 (4%)

Query: 24  VTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTT 83
           +T LD S   LE VP      +K +E L +  N + E+P ++ +  SL KL L  N +  
Sbjct: 504 LTFLDLSRNLLECVPDWACEAKK-IEVLDVSYNLLTEVPVRILSSLSLRKLMLGHNHVQN 562

Query: 84  LPASIANLINLRELDVSKNGIQEFPENIKNCKV-LTIVEASVNPISKLPD---GFSQLLN 139
           LP  + + I L  LD+  N +   P+ + +  + L  + AS N +  LP    G   L  
Sbjct: 563 LPTLVEH-IPLEVLDLQHNALTRLPDTLFSKALNLRYLNASANSLESLPSACTGEESLSM 621

Query: 140 LTQLYLNDAFL--EFLPANFGRLTKLQILELRENQLKMLPKT-MNRLTQLERLDLGSNEF 196
           L  LYL +  L  + +P   G L  L+IL L  NQL+  P + +N+L QLE L+L  N+ 
Sbjct: 622 LQLLYLTNNLLTDQCIPVLVGHL-HLRILHLANNQLQTFPASKLNKLEQLEELNLSGNKL 680

Query: 197 TEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQ 256
             +P  +     L      +N ++  P  +  L Q+ ++D+S N++  +    +    LQ
Sbjct: 681 KTIPTTIANCKRLHTLVAHSNNISIFPEIL-QLPQIQFVDLSCNDLTEILIPEALPATLQ 739

Query: 257 DLLLSSNSLQQLP-ETIGSLKNITTLKIDENQL 288
           DL L+ N+   L  +T+    +ITTLKID+  L
Sbjct: 740 DLDLTGNTNLVLEHKTLDIFSHITTLKIDQKPL 772



 Score = 85.1 bits (209), Expect = 4e-16
 Identities = 81/323 (25%), Positives = 143/323 (44%), Gaps = 43/323 (13%)

Query: 117 LTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEF-LPANFGRLTK---LQILELRENQ 172
           ++ V+ S   + ++P+      ++T L L   F++   P     L K   L+ L L  N+
Sbjct: 251 ISTVDLSCYSLEEVPEHLFYSQDITYLNLRHNFMQLERPGGLDTLYKFSQLKGLNLSHNK 310

Query: 173 LKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQL 232
           L + P  +  ++ L  L+L  N F ++P  +  L  L+   +D N LT +P  +G+L+QL
Sbjct: 311 LGLFPILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEELGNLQQL 370

Query: 233 TYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLP----------------------- 269
           + L +S NN   + E       L  ++++ N L+ L                        
Sbjct: 371 SSLGISFNNFSQIPEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLKTM 430

Query: 270 --ETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTF 327
             E +   K+IT + + +N+L  L   +  L S+E+L C  N++  L  S     +LRT 
Sbjct: 431 VIENLEGNKHITHVDLRDNRLTDL--DLSSLCSLEQLHCGRNQLRELTLS---GFSLRTL 485

Query: 328 AADHNYLQQL----PPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNL 383
            A  N L  +     P +     +T L L  N LE +P+   + +K++V+++S N L  +
Sbjct: 486 YASSNRLTAVNVYPVPSL-----LTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEV 540

Query: 384 PFSFTKLQQLTAMWLSDNQSKPL 406
           P        L  + L  N  + L
Sbjct: 541 PVRILSSLSLRKLMLGHNHVQNL 563



 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 73/295 (24%), Positives = 141/295 (47%), Gaps = 41/295 (13%)

Query: 47  TLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPA-SIANLINLRELDVSKNGIQ 105
           +LE+L+   NQ+ EL    F+ ++L+  S   N LT +    + +L+    LD+S+N ++
Sbjct: 461 SLEQLHCGRNQLRELTLSGFSLRTLYASS---NRLTAVNVYPVPSLLTF--LDLSRNLLE 515

Query: 106 EFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQI 165
             P+     K + +++ S N ++++P      L+L +L L    ++ LP     +  L++
Sbjct: 516 CVPDWACEAKKIEVLDVSYNLLTEVPVRILSSLSLRKLMLGHNHVQNLPTLVEHIP-LEV 574

Query: 166 LELRENQLKMLPKTM-NRLTQLERLDLGSNEFTEVPEVL---EQLSGLKEFWMDANRLT- 220
           L+L+ N L  LP T+ ++   L  L+  +N    +P      E LS L+  ++  N LT 
Sbjct: 575 LDLQHNALTRLPDTLFSKALNLRYLNASANSLESLPSACTGEESLSMLQLLYLTNNLLTD 634

Query: 221 -FIPGFIG-----------------------SLKQLTYLDVSKNNIEMVEEGISTCENLQ 256
             IP  +G                        L+QL  L++S N ++ +   I+ C+ L 
Sbjct: 635 QCIPVLVGHLHLRILHLANNQLQTFPASKLNKLEQLEELNLSGNKLKTIPTTIANCKRLH 694

Query: 257 DLLLSSNSLQQLPETIGSLKNITTLKIDENQL--MYLPDSIGGLISVEELDCSFN 309
            L+  SN++   PE +  L  I  + +  N L  + +P+++    ++++LD + N
Sbjct: 695 TLVAHSNNISIFPEIL-QLPQIQFVDLSCNDLTEILIPEALPA--TLQDLDLTGN 746


>gi|197333692 leucine rich repeat containing 8 family, member B
           [Homo sapiens]
          Length = 803

 Score =  123 bits (308), Expect = 1e-27
 Identities = 103/355 (29%), Positives = 170/355 (47%), Gaps = 11/355 (3%)

Query: 49  EELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNG-IQEF 107
           +++ L    +  LP  +F    +  LSL       LP++++ L+NL+EL V  +  + + 
Sbjct: 420 DKIELHLFMLNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDH 479

Query: 108 PENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFL-EFLPA----NFGRLTK 162
           P      + L I+      + K+P     L NL +LYL+   L E L       F  L  
Sbjct: 480 PALAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKN 539

Query: 163 LQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEV--LEQLSGLKEFWMDANRLT 220
           L+ L L+ +  ++     + L  L++L L  NE +++  +  L+++  LK   + +  L 
Sbjct: 540 LRTLYLKSSLSRIPQVVTDLLPSLQKLSL-DNEGSKLVVLNNLKKMVNLKSLELISCDLE 598

Query: 221 FIPGFIGSLKQLTYLDVSKNNIEMVEEGIST--CENLQDLLLSSNSLQQLPETIGSLKNI 278
            IP  I SL  L  LD+ +NN++ VEE IS    +NL  L L  N++  +P  IG+L N+
Sbjct: 599 RIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNL 658

Query: 279 TTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLP 338
             L +D N +  LP  +     +  LD S+N +  +P  I  L+NL+ FA  +N ++ LP
Sbjct: 659 EQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLP 718

Query: 339 PEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQL 393
             +   K +  L L  N L  L   +G++  L  + L  N L+ LP      Q L
Sbjct: 719 DGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSL 773



 Score =  108 bits (271), Expect = 3e-23
 Identities = 90/294 (30%), Positives = 141/294 (47%), Gaps = 17/294 (5%)

Query: 21  EETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQ--------SLH 72
           EE +  L      + ++P+ +F   K L+ELYL       LP+QL   Q        +L 
Sbjct: 486 EENLKILRLKFTEMGKIPRWVFHL-KNLKELYLSGCV---LPEQLSTMQLEGFQDLKNLR 541

Query: 73  KLSLPDNDLTTLPASIANLI-NLRELDVSKNGIQEFP-ENIKNCKVLTIVEASVNPISKL 130
            L L  + L+ +P  + +L+ +L++L +   G +     N+K    L  +E     + ++
Sbjct: 542 TLYLKSS-LSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERI 600

Query: 131 PDGFSQLLNLTQLYLNDAFLEFLPA--NFGRLTKLQILELRENQLKMLPKTMNRLTQLER 188
           P     L NL +L L +  L+ +    +F  L  L  L+L  N +  +P  +  L+ LE+
Sbjct: 601 PHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQ 660

Query: 189 LDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEG 248
           L L  N    +P  L   + L    +  N LTFIP  I  L  L Y  V+ NNIEM+ +G
Sbjct: 661 LSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDG 720

Query: 249 ISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVE 302
           +  C+ LQ LLL  NSL  L   +G L N+T L++  N L  LP  + G  S++
Sbjct: 721 LFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLK 774



 Score = 99.8 bits (247), Expect = 2e-20
 Identities = 86/346 (24%), Positives = 158/346 (45%), Gaps = 13/346 (3%)

Query: 108 PENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYL-NDAFLEFLPANFGRLTKLQIL 166
           P+N+     + ++   + P  KLP   SQL+NL +L + + + +   PA       L+IL
Sbjct: 433 PDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEENLKIL 492

Query: 167 ELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLE-----QLSGLKEFWMDANRLTF 221
            L+  ++  +P+ +  L  L+ L L      E    ++      L  L+  ++ ++ L+ 
Sbjct: 493 RLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSS-LSR 551

Query: 222 IPGFIGSL-KQLTYLDVSKNNIEMVE-EGISTCENLQDLLLSSNSLQQLPETIGSLKNIT 279
           IP  +  L   L  L +     ++V    +    NL+ L L S  L+++P +I SL N+ 
Sbjct: 552 IPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNLH 611

Query: 280 TLKIDENQLMYLPDSIGGLISVEELDCS---FNEVEALPSSIGQLTNLRTFAADHNYLQQ 336
            L + EN L  + + I     ++ L C     N +  +P+ IG L+NL   + DHN ++ 
Sbjct: 612 ELDLRENNLKTVEEIIS-FQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIEN 670

Query: 337 LPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAM 396
           LP ++     +  L L  N L  +PEE+  +  L+   +++N ++ LP    + ++L  +
Sbjct: 671 LPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCL 730

Query: 397 WLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQPRTEDVMFISDN 442
            L  N    L P   E  + T   ++ NY+    P  E    +  N
Sbjct: 731 LLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRN 776



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 55/167 (32%), Positives = 72/167 (43%), Gaps = 24/167 (14%)

Query: 22  ETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDL 81
           + ++ L   H ++  +P +I      LE+L LD N IE LP QLF C  LH L L  N L
Sbjct: 633 QNLSCLKLWHNNIAYIPAQIGALSN-LEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHL 691

Query: 82  TTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLT 141
           T +P  I  L NL+   V+ N I+                        LPDG  Q   L 
Sbjct: 692 TFIPEEIQYLSNLQYFAVTNNNIE-----------------------MLPDGLFQCKKLQ 728

Query: 142 QLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLER 188
            L L    L  L  + G L+ L  LEL  N L+ LP  +     L+R
Sbjct: 729 CLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKR 775


>gi|21245134 leucine rich repeat containing 8 family, member B [Homo
           sapiens]
          Length = 803

 Score =  123 bits (308), Expect = 1e-27
 Identities = 103/355 (29%), Positives = 170/355 (47%), Gaps = 11/355 (3%)

Query: 49  EELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNG-IQEF 107
           +++ L    +  LP  +F    +  LSL       LP++++ L+NL+EL V  +  + + 
Sbjct: 420 DKIELHLFMLNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDH 479

Query: 108 PENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFL-EFLPA----NFGRLTK 162
           P      + L I+      + K+P     L NL +LYL+   L E L       F  L  
Sbjct: 480 PALAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKN 539

Query: 163 LQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEV--LEQLSGLKEFWMDANRLT 220
           L+ L L+ +  ++     + L  L++L L  NE +++  +  L+++  LK   + +  L 
Sbjct: 540 LRTLYLKSSLSRIPQVVTDLLPSLQKLSL-DNEGSKLVVLNNLKKMVNLKSLELISCDLE 598

Query: 221 FIPGFIGSLKQLTYLDVSKNNIEMVEEGIST--CENLQDLLLSSNSLQQLPETIGSLKNI 278
            IP  I SL  L  LD+ +NN++ VEE IS    +NL  L L  N++  +P  IG+L N+
Sbjct: 599 RIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNL 658

Query: 279 TTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLP 338
             L +D N +  LP  +     +  LD S+N +  +P  I  L+NL+ FA  +N ++ LP
Sbjct: 659 EQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLP 718

Query: 339 PEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQL 393
             +   K +  L L  N L  L   +G++  L  + L  N L+ LP      Q L
Sbjct: 719 DGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSL 773



 Score =  108 bits (271), Expect = 3e-23
 Identities = 90/294 (30%), Positives = 141/294 (47%), Gaps = 17/294 (5%)

Query: 21  EETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQ--------SLH 72
           EE +  L      + ++P+ +F   K L+ELYL       LP+QL   Q        +L 
Sbjct: 486 EENLKILRLKFTEMGKIPRWVFHL-KNLKELYLSGCV---LPEQLSTMQLEGFQDLKNLR 541

Query: 73  KLSLPDNDLTTLPASIANLI-NLRELDVSKNGIQEFP-ENIKNCKVLTIVEASVNPISKL 130
            L L  + L+ +P  + +L+ +L++L +   G +     N+K    L  +E     + ++
Sbjct: 542 TLYLKSS-LSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERI 600

Query: 131 PDGFSQLLNLTQLYLNDAFLEFLPA--NFGRLTKLQILELRENQLKMLPKTMNRLTQLER 188
           P     L NL +L L +  L+ +    +F  L  L  L+L  N +  +P  +  L+ LE+
Sbjct: 601 PHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQ 660

Query: 189 LDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEG 248
           L L  N    +P  L   + L    +  N LTFIP  I  L  L Y  V+ NNIEM+ +G
Sbjct: 661 LSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDG 720

Query: 249 ISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVE 302
           +  C+ LQ LLL  NSL  L   +G L N+T L++  N L  LP  + G  S++
Sbjct: 721 LFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLK 774



 Score = 99.8 bits (247), Expect = 2e-20
 Identities = 86/346 (24%), Positives = 158/346 (45%), Gaps = 13/346 (3%)

Query: 108 PENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYL-NDAFLEFLPANFGRLTKLQIL 166
           P+N+     + ++   + P  KLP   SQL+NL +L + + + +   PA       L+IL
Sbjct: 433 PDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEENLKIL 492

Query: 167 ELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLE-----QLSGLKEFWMDANRLTF 221
            L+  ++  +P+ +  L  L+ L L      E    ++      L  L+  ++ ++ L+ 
Sbjct: 493 RLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSS-LSR 551

Query: 222 IPGFIGSL-KQLTYLDVSKNNIEMVE-EGISTCENLQDLLLSSNSLQQLPETIGSLKNIT 279
           IP  +  L   L  L +     ++V    +    NL+ L L S  L+++P +I SL N+ 
Sbjct: 552 IPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNLH 611

Query: 280 TLKIDENQLMYLPDSIGGLISVEELDCS---FNEVEALPSSIGQLTNLRTFAADHNYLQQ 336
            L + EN L  + + I     ++ L C     N +  +P+ IG L+NL   + DHN ++ 
Sbjct: 612 ELDLRENNLKTVEEIIS-FQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIEN 670

Query: 337 LPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAM 396
           LP ++     +  L L  N L  +PEE+  +  L+   +++N ++ LP    + ++L  +
Sbjct: 671 LPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCL 730

Query: 397 WLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQPRTEDVMFISDN 442
            L  N    L P   E  + T   ++ NY+    P  E    +  N
Sbjct: 731 LLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRN 776



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 55/167 (32%), Positives = 72/167 (43%), Gaps = 24/167 (14%)

Query: 22  ETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDL 81
           + ++ L   H ++  +P +I      LE+L LD N IE LP QLF C  LH L L  N L
Sbjct: 633 QNLSCLKLWHNNIAYIPAQIGALSN-LEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHL 691

Query: 82  TTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLT 141
           T +P  I  L NL+   V+ N I+                        LPDG  Q   L 
Sbjct: 692 TFIPEEIQYLSNLQYFAVTNNNIE-----------------------MLPDGLFQCKKLQ 728

Query: 142 QLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLER 188
            L L    L  L  + G L+ L  LEL  N L+ LP  +     L+R
Sbjct: 729 CLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKR 775


>gi|40217803 leucine rich repeat containing 8 family, member E [Homo
           sapiens]
          Length = 796

 Score =  120 bits (302), Expect = 7e-27
 Identities = 98/353 (27%), Positives = 165/353 (46%), Gaps = 28/353 (7%)

Query: 61  LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQ-EFPENIKNCKVLTI 119
           LP  +F    +  L L      T P  ++ L++L+EL +  +  +  F   +     L +
Sbjct: 429 LPDTVFELSEVESLRLEAICDITFPPGLSQLVHLQELSLLHSPARLPFSLQVFLRDHLKV 488

Query: 120 VEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPA-----NFGRLTKLQILELRENQLK 174
           +      + ++P     L  L +L+L   F + L       +   L +L++L LR N  K
Sbjct: 489 MRVKCEELREVPLWVFGLRGLEELHLEGLFPQELARAATLESLRELKQLKVLSLRSNAGK 548

Query: 175 MLPKTMNRLTQLERLDLGSNEFTEVP-EVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLT 233
           +     +    L+RL L ++    V    L++L+ L+E  + A  L  IP  + SL  L 
Sbjct: 549 VPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAALRELELVACGLERIPHAVFSLGALQ 608

Query: 234 YLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPD 293
            LD+  N++  +EE +S                         + + TL++  NQ+ Y+P+
Sbjct: 609 ELDLKDNHLRSIEEILS---------------------FQHCRKLVTLRLWHNQIAYVPE 647

Query: 294 SIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLH 353
            +  L S+E+L  S+N++E LPS +G  + LR     HN L  LPPE+G  +N+  L L 
Sbjct: 648 HVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALS 707

Query: 354 SNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPL 406
            N LE LPEE+   +KL+ + L DN+L  L      L+ L+ + L  N+ + L
Sbjct: 708 YNALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEAL 760



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 51/155 (32%), Positives = 76/155 (49%), Gaps = 2/155 (1%)

Query: 39  KEIFTFE--KTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRE 96
           +EI +F+  + L  L L  NQI  +P+ +   +SL +L L  N L TLP+ +     LR 
Sbjct: 621 EEILSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRL 680

Query: 97  LDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPAN 156
           LDVS NG+   P  +   + L  +  S N +  LP+       L  L L D  L  L  +
Sbjct: 681 LDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLSPH 740

Query: 157 FGRLTKLQILELRENQLKMLPKTMNRLTQLERLDL 191
            G L  L  LEL+ N+L+ LP+ +     L++  L
Sbjct: 741 VGALRALSRLELKGNRLEALPEELGNCGGLKKAGL 775



 Score = 55.1 bits (131), Expect = 5e-07
 Identities = 71/299 (23%), Positives = 119/299 (39%), Gaps = 61/299 (20%)

Query: 166 LELRENQLKMLPKTMNRLTQLERLDLGS-------------------------------- 193
           LEL    L  LP T+  L+++E L L +                                
Sbjct: 419 LELALCMLPGLPDTVFELSEVESLRLEAICDITFPPGLSQLVHLQELSLLHSPARLPFSL 478

Query: 194 ---------------NEFTEVPEVLEQLSGLKE------FWMDANRLTFIPGFIGSLKQL 232
                           E  EVP  +  L GL+E      F  +  R   +   +  LKQL
Sbjct: 479 QVFLRDHLKVMRVKCEELREVPLWVFGLRGLEELHLEGLFPQELARAATLES-LRELKQL 537

Query: 233 TYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLK---IDENQLM 289
             L +  N  ++         +LQ L L ++  + +   + SLK +  L+   +    L 
Sbjct: 538 KVLSLRSNAGKVPASVTDVAGHLQRLSLHNDGARLV--ALNSLKKLAALRELELVACGLE 595

Query: 290 YLPDSIGGLISVEELDCSFNEVEALPS--SIGQLTNLRTFAADHNYLQQLPPEIGSWKNI 347
            +P ++  L +++ELD   N + ++    S      L T    HN +  +P  +   +++
Sbjct: 596 RIPHAVFSLGALQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSL 655

Query: 348 TVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPL 406
             L+L  NKLETLP ++G    L+++++S N L +LP     LQ L  + LS N  + L
Sbjct: 656 EQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEAL 714


>gi|62241040 leucine rich repeat containing 8 family, member A [Homo
           sapiens]
          Length = 810

 Score =  115 bits (287), Expect = 4e-25
 Identities = 101/349 (28%), Positives = 168/349 (48%), Gaps = 17/349 (4%)

Query: 49  EELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQ-EF 107
           ++L L    +  +P  +F+   L  L L      T+P SIA L  L+EL +     + E 
Sbjct: 426 DKLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEA 485

Query: 108 PENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYL-------NDAFLEFLPANFGRL 160
           P      + L  +      I ++P     L  L +L+L       N+ ++         L
Sbjct: 486 PALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVI--DGLREL 543

Query: 161 TKLQILELRENQLKMLPKTMNRL-TQLERLDLGSNEFTE--VPEVLEQLSGLKEFWMDAN 217
            +L++L L+ N L  LP+ +  +   L++L + +NE T+  V   L++++ L E  +   
Sbjct: 544 KRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSI-NNEGTKLIVLNSLKKMANLTELELIRC 601

Query: 218 RLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGIST--CENLQDLLLSSNSLQQLPETIGSL 275
            L  IP  I SL  L  +D+  NN++ +EE IS      L  L L  N +  +P  IG+L
Sbjct: 602 DLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNL 661

Query: 276 KNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQ 335
            N+  L ++ N++  +P  +     +  LD S N +  LP+ IG L NL+  A   N ++
Sbjct: 662 TNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIE 721

Query: 336 QLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLP 384
            LPPE+   + +  L L +N L++LP  +G++  L  I L  NRL+ LP
Sbjct: 722 TLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLP 770



 Score =  110 bits (276), Expect = 7e-24
 Identities = 88/300 (29%), Positives = 147/300 (49%), Gaps = 19/300 (6%)

Query: 22  ETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLF-----NCQSLHKLSL 76
           E +  L      ++++P  I++  KTLEEL+L  N   E  + +        + L  L L
Sbjct: 493 ENLRALHIKFTDIKEIPLWIYSL-KTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRL 551

Query: 77  PDNDLTTLPASIANL-INLRELDVSKNGIQEFPEN-IKNCKVLTIVEASVNPISKLPDGF 134
             N L+ LP  + ++ ++L++L ++  G +    N +K    LT +E     + ++P   
Sbjct: 552 KSN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSI 610

Query: 135 SQLLNLTQLYLNDAFLEFLPA--NFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLG 192
             L NL ++ L D  L+ +    +F  L +L  L+L  N +  +P  +  LT LERL L 
Sbjct: 611 FSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLN 670

Query: 193 SNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTC 252
            N+  ++P  L     L+   +  N LTF+P  IG L+ L  L ++ N IE +   +  C
Sbjct: 671 RNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQC 730

Query: 253 ENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIG--------GLISVEEL 304
             L+ L L +N LQ LP  +G L N+T +++  N+L  LP  +G        GL+  E+L
Sbjct: 731 RKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDL 790



 Score = 89.4 bits (220), Expect = 2e-17
 Identities = 94/327 (28%), Positives = 149/327 (45%), Gaps = 61/327 (18%)

Query: 140 LTQLYLNDAFLEFLPANFGRLTK--LQILELRENQLKMLPKTMNRLTQLERLDLGSNEFT 197
           L QL LN+ +   L     RLTK     LEL    L  +P T+  L +LE L L      
Sbjct: 402 LRQLNLNNEWT--LDKLRQRLTKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLELIPDV 459

Query: 198 EVPEVLEQLSGLKEFWM-------DANRLTF-----------------IPGFIGSLKQLT 233
            +P  + QL+GLKE W+       +A  L F                 IP +I SLK L 
Sbjct: 460 TIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLE 519

Query: 234 YLDVS-----KNNIEMVEEGISTCENLQDLLLSSNSLQQLPETI---------------- 272
            L ++     +NN  +V +G+   + L+ L L SN L +LP+ +                
Sbjct: 520 ELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEG 578

Query: 273 ------GSLK---NITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIG--QL 321
                  SLK   N+T L++    L  +P SI  L +++E+D   N ++ +   I    L
Sbjct: 579 TKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHL 638

Query: 322 TNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLK 381
             L      +N++  +P +IG+  N+  L+L+ NK+E +P ++   +KL+ ++LS N L 
Sbjct: 639 HRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLT 698

Query: 382 NLPFSFTKLQQLTAMWLSDNQSKPLIP 408
            LP     LQ L  + ++ N+ + L P
Sbjct: 699 FLPADIGLLQNLQNLAITANRIETLPP 725



 Score = 88.6 bits (218), Expect = 4e-17
 Identities = 58/157 (36%), Positives = 80/157 (50%), Gaps = 5/157 (3%)

Query: 23  TVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLT 82
           T   L Y+H  +  +P +I      LE LYL+ N+IE++P QLF C+ L  L L  N+LT
Sbjct: 642 TCLKLWYNH--IAYIPIQIGNLTN-LERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLT 698

Query: 83  TLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQ 142
            LPA I  L NL+ L ++ N I+  P  +  C+ L  +    N +  LP    +L NLTQ
Sbjct: 699 FLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQ 758

Query: 143 LYLNDAFLEFLPANFGR--LTKLQILELRENQLKMLP 177
           + L    LE LP   G   L K   L + E+    LP
Sbjct: 759 IELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLP 795


>gi|187829877 leucine rich repeat containing 8 family, member A
           [Homo sapiens]
          Length = 810

 Score =  115 bits (287), Expect = 4e-25
 Identities = 101/349 (28%), Positives = 168/349 (48%), Gaps = 17/349 (4%)

Query: 49  EELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQ-EF 107
           ++L L    +  +P  +F+   L  L L      T+P SIA L  L+EL +     + E 
Sbjct: 426 DKLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEA 485

Query: 108 PENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYL-------NDAFLEFLPANFGRL 160
           P      + L  +      I ++P     L  L +L+L       N+ ++         L
Sbjct: 486 PALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVI--DGLREL 543

Query: 161 TKLQILELRENQLKMLPKTMNRL-TQLERLDLGSNEFTE--VPEVLEQLSGLKEFWMDAN 217
            +L++L L+ N L  LP+ +  +   L++L + +NE T+  V   L++++ L E  +   
Sbjct: 544 KRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSI-NNEGTKLIVLNSLKKMANLTELELIRC 601

Query: 218 RLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGIST--CENLQDLLLSSNSLQQLPETIGSL 275
            L  IP  I SL  L  +D+  NN++ +EE IS      L  L L  N +  +P  IG+L
Sbjct: 602 DLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNL 661

Query: 276 KNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQ 335
            N+  L ++ N++  +P  +     +  LD S N +  LP+ IG L NL+  A   N ++
Sbjct: 662 TNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIE 721

Query: 336 QLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLP 384
            LPPE+   + +  L L +N L++LP  +G++  L  I L  NRL+ LP
Sbjct: 722 TLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLP 770



 Score =  110 bits (276), Expect = 7e-24
 Identities = 88/300 (29%), Positives = 147/300 (49%), Gaps = 19/300 (6%)

Query: 22  ETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLF-----NCQSLHKLSL 76
           E +  L      ++++P  I++  KTLEEL+L  N   E  + +        + L  L L
Sbjct: 493 ENLRALHIKFTDIKEIPLWIYSL-KTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRL 551

Query: 77  PDNDLTTLPASIANL-INLRELDVSKNGIQEFPEN-IKNCKVLTIVEASVNPISKLPDGF 134
             N L+ LP  + ++ ++L++L ++  G +    N +K    LT +E     + ++P   
Sbjct: 552 KSN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSI 610

Query: 135 SQLLNLTQLYLNDAFLEFLPA--NFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLG 192
             L NL ++ L D  L+ +    +F  L +L  L+L  N +  +P  +  LT LERL L 
Sbjct: 611 FSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLN 670

Query: 193 SNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTC 252
            N+  ++P  L     L+   +  N LTF+P  IG L+ L  L ++ N IE +   +  C
Sbjct: 671 RNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQC 730

Query: 253 ENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIG--------GLISVEEL 304
             L+ L L +N LQ LP  +G L N+T +++  N+L  LP  +G        GL+  E+L
Sbjct: 731 RKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDL 790



 Score = 89.4 bits (220), Expect = 2e-17
 Identities = 94/327 (28%), Positives = 149/327 (45%), Gaps = 61/327 (18%)

Query: 140 LTQLYLNDAFLEFLPANFGRLTK--LQILELRENQLKMLPKTMNRLTQLERLDLGSNEFT 197
           L QL LN+ +   L     RLTK     LEL    L  +P T+  L +LE L L      
Sbjct: 402 LRQLNLNNEWT--LDKLRQRLTKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLELIPDV 459

Query: 198 EVPEVLEQLSGLKEFWM-------DANRLTF-----------------IPGFIGSLKQLT 233
            +P  + QL+GLKE W+       +A  L F                 IP +I SLK L 
Sbjct: 460 TIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLE 519

Query: 234 YLDVS-----KNNIEMVEEGISTCENLQDLLLSSNSLQQLPETI---------------- 272
            L ++     +NN  +V +G+   + L+ L L SN L +LP+ +                
Sbjct: 520 ELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEG 578

Query: 273 ------GSLK---NITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIG--QL 321
                  SLK   N+T L++    L  +P SI  L +++E+D   N ++ +   I    L
Sbjct: 579 TKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHL 638

Query: 322 TNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLK 381
             L      +N++  +P +IG+  N+  L+L+ NK+E +P ++   +KL+ ++LS N L 
Sbjct: 639 HRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLT 698

Query: 382 NLPFSFTKLQQLTAMWLSDNQSKPLIP 408
            LP     LQ L  + ++ N+ + L P
Sbjct: 699 FLPADIGLLQNLQNLAITANRIETLPP 725



 Score = 88.6 bits (218), Expect = 4e-17
 Identities = 58/157 (36%), Positives = 80/157 (50%), Gaps = 5/157 (3%)

Query: 23  TVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLT 82
           T   L Y+H  +  +P +I      LE LYL+ N+IE++P QLF C+ L  L L  N+LT
Sbjct: 642 TCLKLWYNH--IAYIPIQIGNLTN-LERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLT 698

Query: 83  TLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQ 142
            LPA I  L NL+ L ++ N I+  P  +  C+ L  +    N +  LP    +L NLTQ
Sbjct: 699 FLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQ 758

Query: 143 LYLNDAFLEFLPANFGR--LTKLQILELRENQLKMLP 177
           + L    LE LP   G   L K   L + E+    LP
Sbjct: 759 IELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLP 795


>gi|187829871 leucine rich repeat containing 8 family, member A
           [Homo sapiens]
          Length = 810

 Score =  115 bits (287), Expect = 4e-25
 Identities = 101/349 (28%), Positives = 168/349 (48%), Gaps = 17/349 (4%)

Query: 49  EELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQ-EF 107
           ++L L    +  +P  +F+   L  L L      T+P SIA L  L+EL +     + E 
Sbjct: 426 DKLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEA 485

Query: 108 PENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYL-------NDAFLEFLPANFGRL 160
           P      + L  +      I ++P     L  L +L+L       N+ ++         L
Sbjct: 486 PALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVI--DGLREL 543

Query: 161 TKLQILELRENQLKMLPKTMNRL-TQLERLDLGSNEFTE--VPEVLEQLSGLKEFWMDAN 217
            +L++L L+ N L  LP+ +  +   L++L + +NE T+  V   L++++ L E  +   
Sbjct: 544 KRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSI-NNEGTKLIVLNSLKKMANLTELELIRC 601

Query: 218 RLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGIST--CENLQDLLLSSNSLQQLPETIGSL 275
            L  IP  I SL  L  +D+  NN++ +EE IS      L  L L  N +  +P  IG+L
Sbjct: 602 DLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNL 661

Query: 276 KNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQ 335
            N+  L ++ N++  +P  +     +  LD S N +  LP+ IG L NL+  A   N ++
Sbjct: 662 TNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIE 721

Query: 336 QLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLP 384
            LPPE+   + +  L L +N L++LP  +G++  L  I L  NRL+ LP
Sbjct: 722 TLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLP 770



 Score =  110 bits (276), Expect = 7e-24
 Identities = 88/300 (29%), Positives = 147/300 (49%), Gaps = 19/300 (6%)

Query: 22  ETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLF-----NCQSLHKLSL 76
           E +  L      ++++P  I++  KTLEEL+L  N   E  + +        + L  L L
Sbjct: 493 ENLRALHIKFTDIKEIPLWIYSL-KTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRL 551

Query: 77  PDNDLTTLPASIANL-INLRELDVSKNGIQEFPEN-IKNCKVLTIVEASVNPISKLPDGF 134
             N L+ LP  + ++ ++L++L ++  G +    N +K    LT +E     + ++P   
Sbjct: 552 KSN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSI 610

Query: 135 SQLLNLTQLYLNDAFLEFLPA--NFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLG 192
             L NL ++ L D  L+ +    +F  L +L  L+L  N +  +P  +  LT LERL L 
Sbjct: 611 FSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLN 670

Query: 193 SNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTC 252
            N+  ++P  L     L+   +  N LTF+P  IG L+ L  L ++ N IE +   +  C
Sbjct: 671 RNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQC 730

Query: 253 ENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIG--------GLISVEEL 304
             L+ L L +N LQ LP  +G L N+T +++  N+L  LP  +G        GL+  E+L
Sbjct: 731 RKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDL 790



 Score = 89.4 bits (220), Expect = 2e-17
 Identities = 94/327 (28%), Positives = 149/327 (45%), Gaps = 61/327 (18%)

Query: 140 LTQLYLNDAFLEFLPANFGRLTK--LQILELRENQLKMLPKTMNRLTQLERLDLGSNEFT 197
           L QL LN+ +   L     RLTK     LEL    L  +P T+  L +LE L L      
Sbjct: 402 LRQLNLNNEWT--LDKLRQRLTKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLELIPDV 459

Query: 198 EVPEVLEQLSGLKEFWM-------DANRLTF-----------------IPGFIGSLKQLT 233
            +P  + QL+GLKE W+       +A  L F                 IP +I SLK L 
Sbjct: 460 TIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLE 519

Query: 234 YLDVS-----KNNIEMVEEGISTCENLQDLLLSSNSLQQLPETI---------------- 272
            L ++     +NN  +V +G+   + L+ L L SN L +LP+ +                
Sbjct: 520 ELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEG 578

Query: 273 ------GSLK---NITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIG--QL 321
                  SLK   N+T L++    L  +P SI  L +++E+D   N ++ +   I    L
Sbjct: 579 TKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHL 638

Query: 322 TNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLK 381
             L      +N++  +P +IG+  N+  L+L+ NK+E +P ++   +KL+ ++LS N L 
Sbjct: 639 HRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLT 698

Query: 382 NLPFSFTKLQQLTAMWLSDNQSKPLIP 408
            LP     LQ L  + ++ N+ + L P
Sbjct: 699 FLPADIGLLQNLQNLAITANRIETLPP 725



 Score = 88.6 bits (218), Expect = 4e-17
 Identities = 58/157 (36%), Positives = 80/157 (50%), Gaps = 5/157 (3%)

Query: 23  TVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLT 82
           T   L Y+H  +  +P +I      LE LYL+ N+IE++P QLF C+ L  L L  N+LT
Sbjct: 642 TCLKLWYNH--IAYIPIQIGNLTN-LERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLT 698

Query: 83  TLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQ 142
            LPA I  L NL+ L ++ N I+  P  +  C+ L  +    N +  LP    +L NLTQ
Sbjct: 699 FLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQ 758

Query: 143 LYLNDAFLEFLPANFGR--LTKLQILELRENQLKMLP 177
           + L    LE LP   G   L K   L + E+    LP
Sbjct: 759 IELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLP 795


>gi|21389431 leucine rich repeat containing 39 [Homo sapiens]
          Length = 335

 Score =  114 bits (284), Expect = 8e-25
 Identities = 68/218 (31%), Positives = 117/218 (53%), Gaps = 1/218 (0%)

Query: 165 ILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPG 224
           IL++ + + K LP ++ +L QL+   L      ++PE + +   L    +  N ++ IP 
Sbjct: 64  ILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPP 123

Query: 225 FIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSN-SLQQLPETIGSLKNITTLKI 283
            IG L +L  L +S N I+ V + +S C +L+ L L+ N  +  LP+ + +L  +T L +
Sbjct: 124 GIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDL 183

Query: 284 DENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGS 343
             N    +P ++  + ++E LD   N++E LP +I ++ NL T     N +  LP  I +
Sbjct: 184 SMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISN 243

Query: 344 WKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLK 381
            KN+  L L +NKL+ +P  M +M  L+ +N  DN LK
Sbjct: 244 MKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLK 281



 Score =  112 bits (281), Expect = 2e-24
 Identities = 66/234 (28%), Positives = 124/234 (52%), Gaps = 3/234 (1%)

Query: 189 LDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEG 248
           L +   E+  +P  L +L+ L+E+ +    L  IP FIG  + L  LD+S+N I  +  G
Sbjct: 65  LKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPG 124

Query: 249 ISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQ-LMYLPDSIGGLISVEELDCS 307
           I     LQ+L+LS N ++ +P+ + +  ++  L++  N+ +  LP  +  L+ +  LD S
Sbjct: 125 IGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLS 184

Query: 308 FNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDM 367
            N+   +P ++  +  L       N L+QLP  I   +N+  L+L  N++  LP+ + +M
Sbjct: 185 MNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNM 244

Query: 368 QKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDN--QSKPLIPLQKETDSETQK 419
           + L  + LS+N+L+++P    ++  L  +   DN  + K  +P  + TD E ++
Sbjct: 245 KNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLKLKVSLPPSEGTDEEEER 298



 Score = 92.0 bits (227), Expect = 3e-18
 Identities = 73/265 (27%), Positives = 115/265 (43%), Gaps = 60/265 (22%)

Query: 46  KTLEELYLDANQIEE----------LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLR 95
           KTL    L  NQ++E          +P+ +   Q+L  L L  N ++ +P  I  L  L+
Sbjct: 73  KTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQ 132

Query: 96  ELDVSKNGIQEFPENIKNCKVLTIVEASVN-PISKLPDGFSQLLNLTQLYLNDAFLEFLP 154
           EL +S N I+  P+ + NC  L  +E +VN  I  LP   S LL LT L           
Sbjct: 133 ELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHL----------- 181

Query: 155 ANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWM 214
                       +L  N    +P  +  +  LE LD+GSN+  ++P+ +E++  L   W+
Sbjct: 182 ------------DLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWL 229

Query: 215 DANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGS 274
             N +T +P                       + IS  +NL  L+LS+N LQ +P  +  
Sbjct: 230 QRNEITCLP-----------------------QTISNMKNLGTLVLSNNKLQDIPVCMEE 266

Query: 275 LKNITTLKIDENQL---MYLPDSIG 296
           + N+  +   +N L   + LP S G
Sbjct: 267 MANLRFVNFRDNPLKLKVSLPPSEG 291



 Score = 77.4 bits (189), Expect = 9e-14
 Identities = 51/181 (28%), Positives = 86/181 (47%), Gaps = 25/181 (13%)

Query: 19  GEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPD 78
           G  + +  LD S  ++ ++P  I    + L+EL L  N+I+ +PK+L NC SL KL L  
Sbjct: 103 GRFQNLIVLDLSRNTISEIPPGIGLLTR-LQELILSYNKIKTVPKELSNCASLEKLELAV 161

Query: 79  N------------------------DLTTLPASIANLINLRELDVSKNGIQEFPENIKNC 114
           N                        D TT+P ++ N+  L  LD+  N +++ P+ I+  
Sbjct: 162 NRDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERM 221

Query: 115 KVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLK 174
           + L  +    N I+ LP   S + NL  L L++  L+ +P     +  L+ +  R+N LK
Sbjct: 222 QNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLK 281

Query: 175 M 175
           +
Sbjct: 282 L 282



 Score = 61.2 bits (147), Expect = 6e-09
 Identities = 41/139 (29%), Positives = 70/139 (50%), Gaps = 1/139 (0%)

Query: 264 SLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTN 323
           SL +L E +        LKI++ +   LP S+  L  ++E       +  +P  IG+  N
Sbjct: 48  SLTKLREKVTREDGRVILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQN 107

Query: 324 LRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNR-LKN 382
           L       N + ++PP IG    +  L L  NK++T+P+E+ +   L+ + L+ NR + +
Sbjct: 108 LIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICD 167

Query: 383 LPFSFTKLQQLTAMWLSDN 401
           LP   + L +LT + LS N
Sbjct: 168 LPQELSNLLKLTHLDLSMN 186


>gi|19923729 leucine rich repeat containing 8 family, member C [Homo
           sapiens]
          Length = 803

 Score =  112 bits (280), Expect = 2e-24
 Identities = 95/366 (25%), Positives = 170/366 (46%), Gaps = 30/366 (8%)

Query: 51  LYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPEN 110
           L L    +  LP  +F    L  L L       +PA+IA L NL+EL + +  ++     
Sbjct: 426 LELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELSLHQCSVKIHSAA 485

Query: 111 IKNCKV-LTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPAN-----FGRLTKLQ 164
           +   K  L ++    + + +LP     L NL +LYL  +    +  N        L  L+
Sbjct: 486 LSFLKENLKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRNVTLESLRDLKSLK 545

Query: 165 ILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEV--LEQLSGLKEFWMDANRLTFI 222
           IL ++ N  K+    ++  + L+++ +  N+ T++  +  L++++ L E  +    L  I
Sbjct: 546 ILSIKSNVSKIPQAVVDVSSHLQKMCI-HNDGTKLVMLNNLKKMTNLTELELVHCDLERI 604

Query: 223 PGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLK 282
           P  + SL  L  LD+ +NN++ +EE +S                        L+ +T LK
Sbjct: 605 PHAVFSLLSLQELDLKENNLKSIEEIVS---------------------FQHLRKLTVLK 643

Query: 283 IDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIG 342
           +  N + Y+P+ I  L S+E L  S N++E LPS +     +R     +N ++ +PPEIG
Sbjct: 644 LWHNSITYIPEHIKKLTSLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIG 703

Query: 343 SWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQ 402
             +++    +  NK+E+LP+E+   +KLK + +  N L  L      L  L+ + +  N 
Sbjct: 704 VLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNH 763

Query: 403 SKPLIP 408
            + L P
Sbjct: 764 FEILPP 769



 Score =  111 bits (278), Expect = 4e-24
 Identities = 82/292 (28%), Positives = 139/292 (47%), Gaps = 39/292 (13%)

Query: 69  QSLHKLSLPDNDLTTLPASIANLINLREL--------DVSKNGIQEFPENIKNCKVLTIV 120
           ++L  LS+  +D+  LP  +  L NL EL        D+S+N   E   ++K+ K+L+I 
Sbjct: 491 ENLKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISRNVTLESLRDLKSLKILSIK 550

Query: 121 EASVNPISKLP-------------------------DGFSQLLNLTQLYLNDAFLEFLPA 155
               + +SK+P                         +   ++ NLT+L L    LE +P 
Sbjct: 551 ----SNVSKIPQAVVDVSSHLQKMCIHNDGTKLVMLNNLKKMTNLTELELVHCDLERIPH 606

Query: 156 NFGRLTKLQILELRENQLKMLPKTMN--RLTQLERLDLGSNEFTEVPEVLEQLSGLKEFW 213
               L  LQ L+L+EN LK + + ++   L +L  L L  N  T +PE +++L+ L+   
Sbjct: 607 AVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLS 666

Query: 214 MDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIG 273
              N++  +P  +    ++ YLD+S N+I  +   I   ++LQ   ++ N ++ LP+ + 
Sbjct: 667 FSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELY 726

Query: 274 SLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLR 325
             K + TLKI +N L  L   IG L+ +  LD   N  E LP  +G    L+
Sbjct: 727 FCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPELGDCRALK 778



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 47/166 (28%), Positives = 74/166 (44%), Gaps = 3/166 (1%)

Query: 24  VTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTT 83
           +T L   H S+  +P+ I     +LE L    N+IE LP  LF C  +  L L  ND+  
Sbjct: 639 LTVLKLWHNSITYIPEHIKKLT-SLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRF 697

Query: 84  LPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQL 143
           +P  I  L +L+   ++ N ++  P+ +  CK L  ++   N +S L      LL L+ L
Sbjct: 698 IPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYL 757

Query: 144 YLNDAFLEFLPANFG--RLTKLQILELRENQLKMLPKTMNRLTQLE 187
            +     E LP   G  R  K   L + +   + LP  +    + E
Sbjct: 758 DVKGNHFEILPPELGDCRALKRAGLVVEDALFETLPSDVREQMKTE 803



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 50/192 (26%), Positives = 79/192 (41%), Gaps = 24/192 (12%)

Query: 24  VTTLDYSHCSLEQVPKEIFTFE------------KTLEE------------LYLDANQIE 59
           +T L+  HC LE++P  +F+              K++EE            L L  N I 
Sbjct: 591 LTELELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSIT 650

Query: 60  ELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTI 119
            +P+ +    SL +LS   N +  LP+ +     +R LD+S N I+  P  I   + L  
Sbjct: 651 YIPEHIKKLTSLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQY 710

Query: 120 VEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKT 179
              + N +  LPD       L  L +    L  L    G L  L  L+++ N  ++LP  
Sbjct: 711 FSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDVKGNHFEILPPE 770

Query: 180 MNRLTQLERLDL 191
           +     L+R  L
Sbjct: 771 LGDCRALKRAGL 782



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 61/282 (21%), Positives = 126/282 (44%), Gaps = 42/282 (14%)

Query: 167 ELRENQLKML-------PKTMNRLTQLE---RLDLGSNEFTEVPEVLEQLSGLKEFWMDA 216
           E+ EN+LK L       P  + +  Q     RL+L     + +P+ + +++ L+   ++ 
Sbjct: 394 EVSENKLKQLNLNNEWTPDKLRQKLQTNAHNRLELPLIMLSGLPDTVFEITELQSLKLEI 453

Query: 217 NRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTC-ENLQDLLLSSNSLQQLPE----- 270
            +   IP  I  L  L  L + + ++++    +S   ENL+ L +  + +++LP      
Sbjct: 454 IKNVMIPATIAQLDNLQELSLHQCSVKIHSAALSFLKENLKVLSVKFDDMRELPPWMYGL 513

Query: 271 --------------------TIGSLKNITTLKI--DENQLMYLPDSIGGLISVEELDCSF 308
                               T+ SL+++ +LKI   ++ +  +P ++  + S  +  C  
Sbjct: 514 RNLEELYLVGSLSHDISRNVTLESLRDLKSLKILSIKSNVSKIPQAVVDVSSHLQKMCIH 573

Query: 309 NEVEALP--SSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPE--EM 364
           N+   L   +++ ++TNL      H  L+++P  + S  ++  L L  N L+++ E    
Sbjct: 574 NDGTKLVMLNNLKKMTNLTELELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEIVSF 633

Query: 365 GDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPL 406
             ++KL V+ L  N +  +P    KL  L  +  S N+ + L
Sbjct: 634 QHLRKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHNKIEVL 675


>gi|61742786 leucine rich repeat and death domain containing protein
           isoform 3 [Homo sapiens]
          Length = 893

 Score =  112 bits (279), Expect = 3e-24
 Identities = 81/257 (31%), Positives = 130/257 (50%), Gaps = 24/257 (9%)

Query: 131 PDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLD 190
           P G  QLL+L         L+ L   F RL+  +  +L E  L  LP++++ L  L    
Sbjct: 44  PGGCQQLLHLCV----QQPLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSL---- 95

Query: 191 LGSNEFTEVPEVLEQLSGLKEFWMDA---NRLTFIPGFIGSLKQLTYLDVSKNNIEMVEE 247
                      VL+   G +   + A     LT +P  +  L  L +LD+S N++E +  
Sbjct: 96  -----------VLK--GGQRRDTLGACLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPA 142

Query: 248 GISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCS 307
            +     L  LLLS N L +LPE +G+L  +T L +  N+L  LP ++G L +++ LD S
Sbjct: 143 CVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLS 202

Query: 308 FNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDM 367
            N ++ LP  IG L +L       N LQ LP  +   +++ +L LHSN L ++P ++  +
Sbjct: 203 QNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARL 262

Query: 368 QKLKVINLSDNRLKNLP 384
             L  ++L DN+L++LP
Sbjct: 263 PLLTRLDLRDNQLRDLP 279



 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 55/169 (32%), Positives = 85/169 (50%)

Query: 173 LKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQL 232
           L  LP  ++ L  L  LDL  N    +P  + Q+ GL    +  N L+ +P  +G+L  L
Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173

Query: 233 TYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLP 292
           T+L V+ N ++ +   +     LQ L LS N L  LP  IG L ++  L +  N+L  LP
Sbjct: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233

Query: 293 DSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEI 341
            S+ GL S+  L    N + ++P+ + +L  L       N L+ LPPE+
Sbjct: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282



 Score = 82.8 bits (203), Expect = 2e-15
 Identities = 54/162 (33%), Positives = 81/162 (50%)

Query: 81  LTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNL 140
           LT LPA ++ L +L  LD+S N ++  P  +   + L  +  S N +S+LP+    L  L
Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173

Query: 141 TQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVP 200
           T L +    L+ LP   G L+ LQ L+L +N L  LP  +  L  L  L+L SN    +P
Sbjct: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233

Query: 201 EVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNI 242
             L  L  L+   + +N L  +P  +  L  LT LD+  N +
Sbjct: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQL 275



 Score = 80.5 bits (197), Expect = 1e-14
 Identities = 58/204 (28%), Positives = 103/204 (50%), Gaps = 13/204 (6%)

Query: 213 WMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETI 272
           ++  NRL+ +  + G  +QL +L V +  +++++         +D  L   +L QLP+++
Sbjct: 32  FLGGNRLS-LDLYPGGCQQLLHLCVQQP-LQLLQVEFLRLSTHEDPQLLEATLAQLPQSL 89

Query: 273 GSLKNITTLKIDENQ----------LMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLT 322
             L+++  LK  + +          L  LP  + GL  +  LD SFN +E LP+ + Q+ 
Sbjct: 90  SCLRSLV-LKGGQRRDTLGACLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMR 148

Query: 323 NLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKN 382
            L      HN L +LP  +G+   +T L +  N+L+TLP  +G +  L+ ++LS N L  
Sbjct: 149 GLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDT 208

Query: 383 LPFSFTKLQQLTAMWLSDNQSKPL 406
           LP     L  L  + L+ N+ + L
Sbjct: 209 LPPEIGGLGSLLELNLASNRLQSL 232



 Score = 76.3 bits (186), Expect = 2e-13
 Identities = 53/169 (31%), Positives = 83/169 (49%)

Query: 127 ISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQL 186
           ++ LP G S L +L  L L+   LE LPA   ++  L  L L  N L  LP+ +  L  L
Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173

Query: 187 ERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVE 246
             L +  N    +P  L  LS L+   +  N L  +P  IG L  L  L+++ N ++ + 
Sbjct: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233

Query: 247 EGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSI 295
             ++   +L+ L+L SN L  +P  +  L  +T L + +NQL  LP  +
Sbjct: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282



 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 54/166 (32%), Positives = 74/166 (44%)

Query: 58  IEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVL 117
           +  LP  L     L  L L  N L TLPA +  +  L  L +S N + E PE +     L
Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173

Query: 118 TIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLP 177
           T +  + N +  LP     L  L +L L+   L+ LP   G L  L  L L  N+L+ LP
Sbjct: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233

Query: 178 KTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIP 223
            ++  L  L  L L SN    VP  L +L  L    +  N+L  +P
Sbjct: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP 279



 Score = 72.0 bits (175), Expect = 4e-12
 Identities = 51/156 (32%), Positives = 74/156 (47%)

Query: 48  LEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEF 107
           L  L L  N +E LP  +   + L  L L  N L+ LP ++  L  L  L V+ N +Q  
Sbjct: 127 LAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTL 186

Query: 108 PENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILE 167
           P  +     L  ++ S N +  LP     L +L +L L    L+ LPA+   L  L++L 
Sbjct: 187 PPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLV 246

Query: 168 LRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVL 203
           L  N L  +P  + RL  L RLDL  N+  ++P  L
Sbjct: 247 LHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 35/113 (30%), Positives = 58/113 (51%), Gaps = 1/113 (0%)

Query: 19  GEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPD 78
           G    +T L  +H  L+ +P  +     TL+ L L  N ++ LP ++    SL +L+L  
Sbjct: 168 GALPALTFLTVTHNRLQTLPPALGALS-TLQRLDLSQNLLDTLPPEIGGLGSLLELNLAS 226

Query: 79  NDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLP 131
           N L +LPAS+A L +LR L +  N +   P ++    +LT ++   N +  LP
Sbjct: 227 NRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP 279



 Score = 48.5 bits (114), Expect = 4e-05
 Identities = 32/93 (34%), Positives = 48/93 (51%), Gaps = 1/93 (1%)

Query: 19  GEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPD 78
           G   T+  LD S   L+ +P EI      LE L L +N+++ LP  L   +SL  L L  
Sbjct: 191 GALSTLQRLDLSQNLLDTLPPEIGGLGSLLE-LNLASNRLQSLPASLAGLRSLRLLVLHS 249

Query: 79  NDLTTLPASIANLINLRELDVSKNGIQEFPENI 111
           N L ++PA +A L  L  LD+  N +++ P  +
Sbjct: 250 NLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282


>gi|61742784 leucine rich repeat and death domain containing protein
           isoform 1 [Homo sapiens]
          Length = 910

 Score =  112 bits (279), Expect = 3e-24
 Identities = 81/257 (31%), Positives = 130/257 (50%), Gaps = 24/257 (9%)

Query: 131 PDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLD 190
           P G  QLL+L         L+ L   F RL+  +  +L E  L  LP++++ L  L    
Sbjct: 44  PGGCQQLLHLCV----QQPLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSL---- 95

Query: 191 LGSNEFTEVPEVLEQLSGLKEFWMDA---NRLTFIPGFIGSLKQLTYLDVSKNNIEMVEE 247
                      VL+   G +   + A     LT +P  +  L  L +LD+S N++E +  
Sbjct: 96  -----------VLK--GGQRRDTLGACLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPA 142

Query: 248 GISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCS 307
            +     L  LLLS N L +LPE +G+L  +T L +  N+L  LP ++G L +++ LD S
Sbjct: 143 CVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLS 202

Query: 308 FNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDM 367
            N ++ LP  IG L +L       N LQ LP  +   +++ +L LHSN L ++P ++  +
Sbjct: 203 QNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARL 262

Query: 368 QKLKVINLSDNRLKNLP 384
             L  ++L DN+L++LP
Sbjct: 263 PLLTRLDLRDNQLRDLP 279



 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 55/169 (32%), Positives = 85/169 (50%)

Query: 173 LKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQL 232
           L  LP  ++ L  L  LDL  N    +P  + Q+ GL    +  N L+ +P  +G+L  L
Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173

Query: 233 TYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLP 292
           T+L V+ N ++ +   +     LQ L LS N L  LP  IG L ++  L +  N+L  LP
Sbjct: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233

Query: 293 DSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEI 341
            S+ GL S+  L    N + ++P+ + +L  L       N L+ LPPE+
Sbjct: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282



 Score = 82.8 bits (203), Expect = 2e-15
 Identities = 54/162 (33%), Positives = 81/162 (50%)

Query: 81  LTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNL 140
           LT LPA ++ L +L  LD+S N ++  P  +   + L  +  S N +S+LP+    L  L
Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173

Query: 141 TQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVP 200
           T L +    L+ LP   G L+ LQ L+L +N L  LP  +  L  L  L+L SN    +P
Sbjct: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233

Query: 201 EVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNI 242
             L  L  L+   + +N L  +P  +  L  LT LD+  N +
Sbjct: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQL 275



 Score = 80.5 bits (197), Expect = 1e-14
 Identities = 58/204 (28%), Positives = 103/204 (50%), Gaps = 13/204 (6%)

Query: 213 WMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETI 272
           ++  NRL+ +  + G  +QL +L V +  +++++         +D  L   +L QLP+++
Sbjct: 32  FLGGNRLS-LDLYPGGCQQLLHLCVQQP-LQLLQVEFLRLSTHEDPQLLEATLAQLPQSL 89

Query: 273 GSLKNITTLKIDENQ----------LMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLT 322
             L+++  LK  + +          L  LP  + GL  +  LD SFN +E LP+ + Q+ 
Sbjct: 90  SCLRSLV-LKGGQRRDTLGACLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMR 148

Query: 323 NLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKN 382
            L      HN L +LP  +G+   +T L +  N+L+TLP  +G +  L+ ++LS N L  
Sbjct: 149 GLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDT 208

Query: 383 LPFSFTKLQQLTAMWLSDNQSKPL 406
           LP     L  L  + L+ N+ + L
Sbjct: 209 LPPEIGGLGSLLELNLASNRLQSL 232



 Score = 76.3 bits (186), Expect = 2e-13
 Identities = 53/169 (31%), Positives = 83/169 (49%)

Query: 127 ISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQL 186
           ++ LP G S L +L  L L+   LE LPA   ++  L  L L  N L  LP+ +  L  L
Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173

Query: 187 ERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVE 246
             L +  N    +P  L  LS L+   +  N L  +P  IG L  L  L+++ N ++ + 
Sbjct: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233

Query: 247 EGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSI 295
             ++   +L+ L+L SN L  +P  +  L  +T L + +NQL  LP  +
Sbjct: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282



 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 54/166 (32%), Positives = 74/166 (44%)

Query: 58  IEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVL 117
           +  LP  L     L  L L  N L TLPA +  +  L  L +S N + E PE +     L
Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173

Query: 118 TIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLP 177
           T +  + N +  LP     L  L +L L+   L+ LP   G L  L  L L  N+L+ LP
Sbjct: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233

Query: 178 KTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIP 223
            ++  L  L  L L SN    VP  L +L  L    +  N+L  +P
Sbjct: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP 279



 Score = 72.0 bits (175), Expect = 4e-12
 Identities = 51/156 (32%), Positives = 74/156 (47%)

Query: 48  LEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEF 107
           L  L L  N +E LP  +   + L  L L  N L+ LP ++  L  L  L V+ N +Q  
Sbjct: 127 LAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTL 186

Query: 108 PENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILE 167
           P  +     L  ++ S N +  LP     L +L +L L    L+ LPA+   L  L++L 
Sbjct: 187 PPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLV 246

Query: 168 LRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVL 203
           L  N L  +P  + RL  L RLDL  N+  ++P  L
Sbjct: 247 LHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 35/113 (30%), Positives = 58/113 (51%), Gaps = 1/113 (0%)

Query: 19  GEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPD 78
           G    +T L  +H  L+ +P  +     TL+ L L  N ++ LP ++    SL +L+L  
Sbjct: 168 GALPALTFLTVTHNRLQTLPPALGALS-TLQRLDLSQNLLDTLPPEIGGLGSLLELNLAS 226

Query: 79  NDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLP 131
           N L +LPAS+A L +LR L +  N +   P ++    +LT ++   N +  LP
Sbjct: 227 NRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP 279



 Score = 48.5 bits (114), Expect = 4e-05
 Identities = 32/93 (34%), Positives = 48/93 (51%), Gaps = 1/93 (1%)

Query: 19  GEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPD 78
           G   T+  LD S   L+ +P EI      LE L L +N+++ LP  L   +SL  L L  
Sbjct: 191 GALSTLQRLDLSQNLLDTLPPEIGGLGSLLE-LNLASNRLQSLPASLAGLRSLRLLVLHS 249

Query: 79  NDLTTLPASIANLINLRELDVSKNGIQEFPENI 111
           N L ++PA +A L  L  LD+  N +++ P  +
Sbjct: 250 NLLASVPADLARLPLLTRLDLRDNQLRDLPPEL 282


>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
           sapiens]
          Length = 587

 Score =  111 bits (278), Expect = 4e-24
 Identities = 113/404 (27%), Positives = 183/404 (45%), Gaps = 49/404 (12%)

Query: 66  FNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEF-PENIKNCKVLTIVEASV 124
           +N  SL  L+    +L   P    N+  L  L + KN +    P   +N   L  +  + 
Sbjct: 59  WNAMSLQILNTHITELNESP--FLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLAN 116

Query: 125 NPISKLPDGFSQLLNLTQLYL--NDAFLEFLPANFGRLTKLQILELRENQLKMLPK-TMN 181
           N +  LP G  Q L+  +  L  ++  L+  PA+F + + L+ L+L  N L+ +P    +
Sbjct: 117 NKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFD 176

Query: 182 RLTQLERLDLGSNEFTEV-PEVLEQLSGLKEFWMDANRLTFIP-GFIGSLKQLTYLDVSK 239
            L  L +L+LG N  T + P V + L  L+   +  NRLT IP G    L  L  L + +
Sbjct: 177 HLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQ 236

Query: 240 NNIEMVEEGI-STCENLQDLLLSSNSLQQLPETI-------------------------G 273
           N I ++  G+     NLQ L LS+N + QLP +I                         G
Sbjct: 237 NQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFG 296

Query: 274 SLKNITTLKIDENQLMYLPDSI-GGLISVEELDCSFNEVEAL-PSSIGQLTNLRTFAADH 331
            + N+  L + +N +  LPD++   L  ++ L  S N++  + P +   LT LR  +   
Sbjct: 297 PMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHT 356

Query: 332 NYLQQLPPEI-GSWKNITVLFLHSNKLETLPEEM-GDMQKLKVINLSDNRLKNLPFS-FT 388
           N LQ L   +     N+  + L +N+L  LP  +  ++  L  I L +N+L+NLP   F 
Sbjct: 357 NALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFD 416

Query: 389 KLQQLTAMWLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQPR 432
            L +L  + L DN      P + ++D     + L N++   QPR
Sbjct: 417 HLGKLCELRLYDN------PWRCDSDI----LPLRNWLLLNQPR 450



 Score =  110 bits (275), Expect = 9e-24
 Identities = 98/342 (28%), Positives = 167/342 (48%), Gaps = 14/342 (4%)

Query: 51  LYLDANQIEELPKQLF-NCQSLHKLSLPDNDLTTLPASI-ANLINLRELDVSKNGIQEF- 107
           L ++ N++  +    F N  SL  LSL +N L  LP  +   L +L  L +S N + +  
Sbjct: 88  LRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQ 147

Query: 108 PENIKNCKVLTIVEASVNPISKLPDG-FSQLLNLTQLYL-NDAFLEFLPANFGRLTKLQI 165
           P +   C  L  ++   N +  +PDG F  L+ LT+L L  ++     P  F  L  LQ+
Sbjct: 148 PAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQV 207

Query: 166 LELRENQLKMLPK-TMNRLTQLERLDLGSNEFTEV-PEVLEQLSGLKEFWMDANRLTFI- 222
           L L EN+L  +P  T + L  L+ L L  N+   + P +      L+  ++  N ++ + 
Sbjct: 208 LRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLP 267

Query: 223 PGFIGSLKQLTYLDVSKNNIEMVEEGI-STCENLQDLLLSSNSLQQLPETI-GSLKNITT 280
           P     L QL  L +  N+++ +  GI     NL++L L  N +  LP+ +  +L+ +  
Sbjct: 268 PSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQV 327

Query: 281 LKIDENQLMYL-PDSIGGLISVEELDCSFNEVEALPSSI-GQLTNLRTFAADHNYLQQLP 338
           L +  NQ+ ++ P +  GL  + EL    N ++ L  ++   L NL+  +  +N L+QLP
Sbjct: 328 LILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLP 387

Query: 339 PEI-GSWKNITVLFLHSNKLETLPEEMGD-MQKLKVINLSDN 378
             I  +   +  + L +N+LE LP  + D + KL  + L DN
Sbjct: 388 GNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDN 429



 Score = 72.0 bits (175), Expect = 4e-12
 Identities = 67/222 (30%), Positives = 99/222 (44%), Gaps = 28/222 (12%)

Query: 34  LEQVPKEIFTFEKTLEELYLDANQIEELPKQLF-NCQSLHKLSLPDNDLTTLPASI-ANL 91
           L  +P   F     L+EL L  NQI  L   LF N  +L +L L +N ++ LP SI   L
Sbjct: 215 LTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQL 274

Query: 92  INLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLE 151
             L  L +  N ++E    I                      F  + NL +L+L D  + 
Sbjct: 275 PQLNRLTLFGNSLKELSLGI----------------------FGPMPNLRELWLYDNHIS 312

Query: 152 FLPAN-FGRLTKLQILELRENQLKML-PKTMNRLTQLERLDLGSNEFTEVP-EVLEQLSG 208
            LP N F  L +LQ+L L  NQ+  + P   N LT+L  L L +N   ++   V   L+ 
Sbjct: 313 SLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLAN 372

Query: 209 LKEFWMDANRLTFIPGFI-GSLKQLTYLDVSKNNIEMVEEGI 249
           L+   +  NRL  +PG I  ++  L  + +  N +E +  GI
Sbjct: 373 LQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGI 414



 Score = 52.4 bits (124), Expect = 3e-06
 Identities = 44/148 (29%), Positives = 65/148 (43%), Gaps = 25/148 (16%)

Query: 33  SLEQVPKEIFTFEKTLEELYLDANQIEELPKQLF-NCQSLHKLSLPDNDLTTL-PASIAN 90
           SL+++   IF     L EL+L  N I  LP  +F N + L  L L  N ++ + P +   
Sbjct: 286 SLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNG 345

Query: 91  LINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFL 150
           L  LREL +  N +Q+   N+                      F  L NL  + L +  L
Sbjct: 346 LTELRELSLHTNALQDLDGNV----------------------FRMLANLQNISLQNNRL 383

Query: 151 EFLPAN-FGRLTKLQILELRENQLKMLP 177
             LP N F  +  L  ++L+ NQL+ LP
Sbjct: 384 RQLPGNIFANVNGLMAIQLQNNQLENLP 411


>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
           sapiens]
          Length = 581

 Score =  111 bits (278), Expect = 4e-24
 Identities = 113/404 (27%), Positives = 183/404 (45%), Gaps = 49/404 (12%)

Query: 66  FNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEF-PENIKNCKVLTIVEASV 124
           +N  SL  L+    +L   P    N+  L  L + KN +    P   +N   L  +  + 
Sbjct: 53  WNAMSLQILNTHITELNESP--FLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLAN 110

Query: 125 NPISKLPDGFSQLLNLTQLYL--NDAFLEFLPANFGRLTKLQILELRENQLKMLPK-TMN 181
           N +  LP G  Q L+  +  L  ++  L+  PA+F + + L+ L+L  N L+ +P    +
Sbjct: 111 NKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFD 170

Query: 182 RLTQLERLDLGSNEFTEV-PEVLEQLSGLKEFWMDANRLTFIP-GFIGSLKQLTYLDVSK 239
            L  L +L+LG N  T + P V + L  L+   +  NRLT IP G    L  L  L + +
Sbjct: 171 HLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQ 230

Query: 240 NNIEMVEEGI-STCENLQDLLLSSNSLQQLPETI-------------------------G 273
           N I ++  G+     NLQ L LS+N + QLP +I                         G
Sbjct: 231 NQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFG 290

Query: 274 SLKNITTLKIDENQLMYLPDSI-GGLISVEELDCSFNEVEAL-PSSIGQLTNLRTFAADH 331
            + N+  L + +N +  LPD++   L  ++ L  S N++  + P +   LT LR  +   
Sbjct: 291 PMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHT 350

Query: 332 NYLQQLPPEI-GSWKNITVLFLHSNKLETLPEEM-GDMQKLKVINLSDNRLKNLPFS-FT 388
           N LQ L   +     N+  + L +N+L  LP  +  ++  L  I L +N+L+NLP   F 
Sbjct: 351 NALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFD 410

Query: 389 KLQQLTAMWLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQPR 432
            L +L  + L DN      P + ++D     + L N++   QPR
Sbjct: 411 HLGKLCELRLYDN------PWRCDSDI----LPLRNWLLLNQPR 444



 Score =  110 bits (275), Expect = 9e-24
 Identities = 98/342 (28%), Positives = 167/342 (48%), Gaps = 14/342 (4%)

Query: 51  LYLDANQIEELPKQLF-NCQSLHKLSLPDNDLTTLPASI-ANLINLRELDVSKNGIQEF- 107
           L ++ N++  +    F N  SL  LSL +N L  LP  +   L +L  L +S N + +  
Sbjct: 82  LRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQ 141

Query: 108 PENIKNCKVLTIVEASVNPISKLPDG-FSQLLNLTQLYL-NDAFLEFLPANFGRLTKLQI 165
           P +   C  L  ++   N +  +PDG F  L+ LT+L L  ++     P  F  L  LQ+
Sbjct: 142 PAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQV 201

Query: 166 LELRENQLKMLPK-TMNRLTQLERLDLGSNEFTEV-PEVLEQLSGLKEFWMDANRLTFI- 222
           L L EN+L  +P  T + L  L+ L L  N+   + P +      L+  ++  N ++ + 
Sbjct: 202 LRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLP 261

Query: 223 PGFIGSLKQLTYLDVSKNNIEMVEEGI-STCENLQDLLLSSNSLQQLPETI-GSLKNITT 280
           P     L QL  L +  N+++ +  GI     NL++L L  N +  LP+ +  +L+ +  
Sbjct: 262 PSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQV 321

Query: 281 LKIDENQLMYL-PDSIGGLISVEELDCSFNEVEALPSSI-GQLTNLRTFAADHNYLQQLP 338
           L +  NQ+ ++ P +  GL  + EL    N ++ L  ++   L NL+  +  +N L+QLP
Sbjct: 322 LILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLP 381

Query: 339 PEI-GSWKNITVLFLHSNKLETLPEEMGD-MQKLKVINLSDN 378
             I  +   +  + L +N+LE LP  + D + KL  + L DN
Sbjct: 382 GNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDN 423



 Score = 72.0 bits (175), Expect = 4e-12
 Identities = 67/222 (30%), Positives = 99/222 (44%), Gaps = 28/222 (12%)

Query: 34  LEQVPKEIFTFEKTLEELYLDANQIEELPKQLF-NCQSLHKLSLPDNDLTTLPASI-ANL 91
           L  +P   F     L+EL L  NQI  L   LF N  +L +L L +N ++ LP SI   L
Sbjct: 209 LTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQL 268

Query: 92  INLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLE 151
             L  L +  N ++E    I                      F  + NL +L+L D  + 
Sbjct: 269 PQLNRLTLFGNSLKELSLGI----------------------FGPMPNLRELWLYDNHIS 306

Query: 152 FLPAN-FGRLTKLQILELRENQLKML-PKTMNRLTQLERLDLGSNEFTEVP-EVLEQLSG 208
            LP N F  L +LQ+L L  NQ+  + P   N LT+L  L L +N   ++   V   L+ 
Sbjct: 307 SLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLAN 366

Query: 209 LKEFWMDANRLTFIPGFI-GSLKQLTYLDVSKNNIEMVEEGI 249
           L+   +  NRL  +PG I  ++  L  + +  N +E +  GI
Sbjct: 367 LQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGI 408



 Score = 52.4 bits (124), Expect = 3e-06
 Identities = 44/148 (29%), Positives = 65/148 (43%), Gaps = 25/148 (16%)

Query: 33  SLEQVPKEIFTFEKTLEELYLDANQIEELPKQLF-NCQSLHKLSLPDNDLTTL-PASIAN 90
           SL+++   IF     L EL+L  N I  LP  +F N + L  L L  N ++ + P +   
Sbjct: 280 SLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNG 339

Query: 91  LINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFL 150
           L  LREL +  N +Q+   N+                      F  L NL  + L +  L
Sbjct: 340 LTELRELSLHTNALQDLDGNV----------------------FRMLANLQNISLQNNRL 377

Query: 151 EFLPAN-FGRLTKLQILELRENQLKMLP 177
             LP N F  +  L  ++L+ NQL+ LP
Sbjct: 378 RQLPGNIFANVNGLMAIQLQNNQLENLP 405


>gi|197333706 leucine rich repeat containing 8 family, member D
           [Homo sapiens]
          Length = 858

 Score =  110 bits (276), Expect = 7e-24
 Identities = 87/323 (26%), Positives = 153/323 (47%), Gaps = 31/323 (9%)

Query: 71  LHKLSLPDNDLTTLPASIANLINLRELDV-----SKNGIQEFPENIKNCKVLTIVEASVN 125
           L  L +   D+  +PA +  L NLREL +     S+N      E+++  + L I+    N
Sbjct: 539 LRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSN 598

Query: 126 PISKLPDGFSQLL-NLTQLYLNDAFLEFLPAN-FGRLTKLQILELRENQLKMLPKTMNRL 183
            ++K+P   + +  +LT+L +++   + L  N   ++  +  LEL+  +L+ +P  +  L
Sbjct: 599 -LTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSL 657

Query: 184 TQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIE 243
           + L+ LDL SN    + E++                         LK+LT L +  N I 
Sbjct: 658 SNLQELDLKSNNIRTIEEIIS---------------------FQHLKRLTCLKLWHNKIV 696

Query: 244 MVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEE 303
            +   I+  +NL+ L  S+N L+ LP  + SL+ +  L +  N +  +P  IG L +++ 
Sbjct: 697 TIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQH 756

Query: 304 LDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEE 363
           L  + N+V+ LP  + +   LRT     N +  LP ++G    +T L L  N L+ LP +
Sbjct: 757 LHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQ 816

Query: 364 MGDMQKLKVINL--SDNRLKNLP 384
           +G  + LK   L   D+    LP
Sbjct: 817 LGQCRMLKKSGLVVEDHLFDTLP 839



 Score =  110 bits (274), Expect = 1e-23
 Identities = 100/380 (26%), Positives = 175/380 (46%), Gaps = 46/380 (12%)

Query: 42  FTFEKTLEELYLDANQIEEL--------PKQLFNCQSLHKLSLPDNDLTTLPASIANLIN 93
           +TFEK  + +  +A   +EL        P  +F+   L  L L       +PA I+ + N
Sbjct: 455 WTFEKLRQHISRNAQDKQELHLFMLSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTN 514

Query: 94  LRELDVSKNGIQEFPENIKNCKV------LTIVEASVNPISKLPDGFSQLLNLTQLYLND 147
           L+EL +        P  ++          L  +      ++++P     L NL +LYL  
Sbjct: 515 LQELHLC-----HCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYL-- 567

Query: 148 AFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVP----EVL 203
                     G L         EN   +  +++  L  L+ L + SN  T+VP    +V 
Sbjct: 568 ---------IGNLNS-------ENNKMIGLESLRELRHLKILHVKSN-LTKVPSNITDVA 610

Query: 204 EQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSN 263
             L+ L     D  +L  +   +  +  +  L++    +E +   I +  NLQ+L L SN
Sbjct: 611 PHLTKLV-IHNDGTKLLVLNS-LKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSN 668

Query: 264 SLQQLPETIG--SLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQL 321
           +++ + E I    LK +T LK+  N+++ +P SI  + ++E L  S N++E+LP ++  L
Sbjct: 669 NIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSL 728

Query: 322 TNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLK 381
             LR     +N +  +P EIG  +N+  L +  NK++ LP+++    KL+ +NL  N + 
Sbjct: 729 QKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCIT 788

Query: 382 NLPFSFTKLQQLTAMWLSDN 401
           +LP    +L QLT + L  N
Sbjct: 789 SLPEKVGQLSQLTQLELKGN 808



 Score = 89.7 bits (221), Expect = 2e-17
 Identities = 59/191 (30%), Positives = 101/191 (52%), Gaps = 5/191 (2%)

Query: 24  VTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLS---LPDND 80
           V  L+  +C LE++P  IF+    L+EL L +N I  + +++ + Q L +L+   L  N 
Sbjct: 637 VAELELQNCELERIPHAIFSL-SNLQELDLKSNNIRTI-EEIISFQHLKRLTCLKLWHNK 694

Query: 81  LTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNL 140
           + T+P SI ++ NL  L  S N ++  P  + + + L  ++ S N IS +P     L NL
Sbjct: 695 IVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNL 754

Query: 141 TQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVP 200
             L++    ++ LP    +  KL+ L L +N +  LP+ + +L+QL +L+L  N    +P
Sbjct: 755 QHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLP 814

Query: 201 EVLEQLSGLKE 211
             L Q   LK+
Sbjct: 815 AQLGQCRMLKK 825



 Score = 89.0 bits (219), Expect = 3e-17
 Identities = 74/285 (25%), Positives = 135/285 (47%), Gaps = 9/285 (3%)

Query: 127 ISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQ- 185
           +S +PD    L +L  L L       +PA   ++T LQ L L     K+     + L   
Sbjct: 479 LSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDH 538

Query: 186 LERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIG--SLKQLTYLDVS--KNN 241
           L  L +   +  E+P  +  L  L+E ++  N  +     IG  SL++L +L +   K+N
Sbjct: 539 LRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSN 598

Query: 242 IEMVEEGIS-TCENLQDLLLSSNSLQQLP-ETIGSLKNITTLKIDENQLMYLPDSIGGLI 299
           +  V   I+    +L  L++ ++  + L   ++  + N+  L++   +L  +P +I  L 
Sbjct: 599 LTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLS 658

Query: 300 SVEELDCSFNEVEALPSSIG--QLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKL 357
           +++ELD   N +  +   I    L  L      HN +  +PP I   KN+  L+  +NKL
Sbjct: 659 NLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKL 718

Query: 358 ETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQ 402
           E+LP  +  +QKL+ +++S N +  +P     LQ L  + ++ N+
Sbjct: 719 ESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNK 763


>gi|34222199 leucine rich repeat containing 8 family, member D [Homo
           sapiens]
          Length = 858

 Score =  110 bits (276), Expect = 7e-24
 Identities = 87/323 (26%), Positives = 153/323 (47%), Gaps = 31/323 (9%)

Query: 71  LHKLSLPDNDLTTLPASIANLINLRELDV-----SKNGIQEFPENIKNCKVLTIVEASVN 125
           L  L +   D+  +PA +  L NLREL +     S+N      E+++  + L I+    N
Sbjct: 539 LRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSN 598

Query: 126 PISKLPDGFSQLL-NLTQLYLNDAFLEFLPAN-FGRLTKLQILELRENQLKMLPKTMNRL 183
            ++K+P   + +  +LT+L +++   + L  N   ++  +  LEL+  +L+ +P  +  L
Sbjct: 599 -LTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSL 657

Query: 184 TQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIE 243
           + L+ LDL SN    + E++                         LK+LT L +  N I 
Sbjct: 658 SNLQELDLKSNNIRTIEEIIS---------------------FQHLKRLTCLKLWHNKIV 696

Query: 244 MVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEE 303
            +   I+  +NL+ L  S+N L+ LP  + SL+ +  L +  N +  +P  IG L +++ 
Sbjct: 697 TIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQH 756

Query: 304 LDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEE 363
           L  + N+V+ LP  + +   LRT     N +  LP ++G    +T L L  N L+ LP +
Sbjct: 757 LHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQ 816

Query: 364 MGDMQKLKVINL--SDNRLKNLP 384
           +G  + LK   L   D+    LP
Sbjct: 817 LGQCRMLKKSGLVVEDHLFDTLP 839



 Score =  110 bits (274), Expect = 1e-23
 Identities = 100/380 (26%), Positives = 175/380 (46%), Gaps = 46/380 (12%)

Query: 42  FTFEKTLEELYLDANQIEEL--------PKQLFNCQSLHKLSLPDNDLTTLPASIANLIN 93
           +TFEK  + +  +A   +EL        P  +F+   L  L L       +PA I+ + N
Sbjct: 455 WTFEKLRQHISRNAQDKQELHLFMLSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTN 514

Query: 94  LRELDVSKNGIQEFPENIKNCKV------LTIVEASVNPISKLPDGFSQLLNLTQLYLND 147
           L+EL +        P  ++          L  +      ++++P     L NL +LYL  
Sbjct: 515 LQELHLC-----HCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYL-- 567

Query: 148 AFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVP----EVL 203
                     G L         EN   +  +++  L  L+ L + SN  T+VP    +V 
Sbjct: 568 ---------IGNLNS-------ENNKMIGLESLRELRHLKILHVKSN-LTKVPSNITDVA 610

Query: 204 EQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSN 263
             L+ L     D  +L  +   +  +  +  L++    +E +   I +  NLQ+L L SN
Sbjct: 611 PHLTKLV-IHNDGTKLLVLNS-LKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSN 668

Query: 264 SLQQLPETIG--SLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQL 321
           +++ + E I    LK +T LK+  N+++ +P SI  + ++E L  S N++E+LP ++  L
Sbjct: 669 NIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSL 728

Query: 322 TNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLK 381
             LR     +N +  +P EIG  +N+  L +  NK++ LP+++    KL+ +NL  N + 
Sbjct: 729 QKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCIT 788

Query: 382 NLPFSFTKLQQLTAMWLSDN 401
           +LP    +L QLT + L  N
Sbjct: 789 SLPEKVGQLSQLTQLELKGN 808



 Score = 89.7 bits (221), Expect = 2e-17
 Identities = 59/191 (30%), Positives = 101/191 (52%), Gaps = 5/191 (2%)

Query: 24  VTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLS---LPDND 80
           V  L+  +C LE++P  IF+    L+EL L +N I  + +++ + Q L +L+   L  N 
Sbjct: 637 VAELELQNCELERIPHAIFSL-SNLQELDLKSNNIRTI-EEIISFQHLKRLTCLKLWHNK 694

Query: 81  LTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNL 140
           + T+P SI ++ NL  L  S N ++  P  + + + L  ++ S N IS +P     L NL
Sbjct: 695 IVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNL 754

Query: 141 TQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVP 200
             L++    ++ LP    +  KL+ L L +N +  LP+ + +L+QL +L+L  N    +P
Sbjct: 755 QHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLP 814

Query: 201 EVLEQLSGLKE 211
             L Q   LK+
Sbjct: 815 AQLGQCRMLKK 825



 Score = 89.0 bits (219), Expect = 3e-17
 Identities = 74/285 (25%), Positives = 135/285 (47%), Gaps = 9/285 (3%)

Query: 127 ISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQ- 185
           +S +PD    L +L  L L       +PA   ++T LQ L L     K+     + L   
Sbjct: 479 LSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDH 538

Query: 186 LERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIG--SLKQLTYLDVS--KNN 241
           L  L +   +  E+P  +  L  L+E ++  N  +     IG  SL++L +L +   K+N
Sbjct: 539 LRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSN 598

Query: 242 IEMVEEGIS-TCENLQDLLLSSNSLQQLP-ETIGSLKNITTLKIDENQLMYLPDSIGGLI 299
           +  V   I+    +L  L++ ++  + L   ++  + N+  L++   +L  +P +I  L 
Sbjct: 599 LTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLS 658

Query: 300 SVEELDCSFNEVEALPSSIG--QLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKL 357
           +++ELD   N +  +   I    L  L      HN +  +PP I   KN+  L+  +NKL
Sbjct: 659 NLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKL 718

Query: 358 ETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQ 402
           E+LP  +  +QKL+ +++S N +  +P     LQ L  + ++ N+
Sbjct: 719 ESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNK 763


>gi|37221175 PH domain and leucine rich repeat protein phosphatase
           [Homo sapiens]
          Length = 1205

 Score =  105 bits (261), Expect = 4e-22
 Identities = 110/424 (25%), Positives = 186/424 (43%), Gaps = 63/424 (14%)

Query: 34  LEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLT---TLPAS--- 87
           L QV K      + +  + L    +E LP  LF  Q L  L+L  N L    +LPA+   
Sbjct: 116 LRQVSK---VASQRISSVDLSCCSLEHLPANLFYSQDLTHLNLKQNFLRQNPSLPAARGL 172

Query: 88  --IANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYL 145
             +     L+ L++S N + +FP  +  C + T+ E +V+  +                 
Sbjct: 173 NELQRFTKLKSLNLSNNHLGDFPLAV--CSIPTLAELNVSCNA----------------- 213

Query: 146 NDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQ 205
               L  +PA  G +  LQ   L  N L+ LP  +  + QL  L L  NEFT++PEVLE+
Sbjct: 214 ----LRSVPAAVGVMHNLQTFLLDGNFLQSLPAELENMKQLSYLGLSFNEFTDIPEVLEK 269

Query: 206 LSGLKEFWMDANRL-TFIPGFIGSLKQLTYLDVSKNNI-EMVEEGISTCENLQDLLLSSN 263
           L+ + +  M  N + T     +  +  + ++D+  N I +++ + +   +++  L L  N
Sbjct: 270 LTAVDKLCMSGNCVETLRLQALRKMPHIKHVDLRLNVIRKLIADEVDFLQHVTQLDLRDN 329

Query: 264 SLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLIS--------------------VEE 303
            L  L   I    NI  L  + NQL+ L D  G  +                     +  
Sbjct: 330 KLGDLDAMI--FNNIEVLHCERNQLVTL-DICGYFLKALYASSNELVQLDVYPVPNYLSY 386

Query: 304 LDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEE 363
           +D S N +E +P  + +   L      HN + +LP  +    ++  L    N+L  LPE 
Sbjct: 387 MDVSRNRLENVPEWVCESRKLEVLDIGHNQICELPARLFCNSSLRKLLAGHNQLARLPER 446

Query: 364 MGDMQKLKVINLSDNRLKNLPFS-FTKLQQLTAMWLSDNQSKPLIP--LQKETDSETQKM 420
           + +   ++V+++  N+L  LP +   K   L  +  S N+ + L P  L +ET+S  Q++
Sbjct: 447 L-ERTSVEVLDVQHNQLLELPPNLLMKADSLRFLNASANKLESLPPATLSEETNSILQEL 505

Query: 421 VLTN 424
            LTN
Sbjct: 506 YLTN 509



 Score = 85.5 bits (210), Expect = 3e-16
 Identities = 105/429 (24%), Positives = 184/429 (42%), Gaps = 78/429 (18%)

Query: 23  TVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLT 82
           T+  L+ S  +L  VP  +      L+   LD N ++ LP +L N + L  L L  N+ T
Sbjct: 203 TLAELNVSCNALRSVPAAVGVMHN-LQTFLLDGNFLQSLPAELENMKQLSYLGLSFNEFT 261

Query: 83  TLPASIANLINLRELDVSKNGIQEFP-ENIKNCKVLTIVEASVNPISKL-PDGFSQLLNL 140
            +P  +  L  + +L +S N ++    + ++    +  V+  +N I KL  D    L ++
Sbjct: 262 DIPEVLEKLTAVDKLCMSGNCVETLRLQALRKMPHIKHVDLRLNVIRKLIADEVDFLQHV 321

Query: 141 TQLYLNDA-------------------------------FLEFLPANFGRLTKLQI---- 165
           TQL L D                                FL+ L A+   L +L +    
Sbjct: 322 TQLDLRDNKLGDLDAMIFNNIEVLHCERNQLVTLDICGYFLKALYASSNELVQLDVYPVP 381

Query: 166 -----LELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLT 220
                +++  N+L+ +P+ +    +LE LD+G N+  E+P  L   S L++     N+L 
Sbjct: 382 NYLSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQICELPARLFCNSSLRKLLAGHNQLA 441

Query: 221 FIP-----------------------GFIGSLKQLTYLDVSKNNIEMVEEGISTCEN--- 254
            +P                         +     L +L+ S N +E +     + E    
Sbjct: 442 RLPERLERTSVEVLDVQHNQLLELPPNLLMKADSLRFLNASANKLESLPPATLSEETNSI 501

Query: 255 LQDLLLSSNSLQQ--LPETIGSLKNITTLKIDENQLMYLPDS-IGGLISVEELDCSFNEV 311
           LQ+L L++NSL    +P   G   ++  L +  N+L   P S +  L  +EE+D S N++
Sbjct: 502 LQELYLTNNSLTDKCVPLLTGH-PHLKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKL 560

Query: 312 EALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLE--TLPEEMGDMQK 369
           +A+P++I     + T  A  N ++   PE+     I  + L  N+L   TLPE +    K
Sbjct: 561 KAIPTTIMNCRRMHTVIAHSNCIEVF-PEVMQLPEIKCVDLSCNELSEVTLPENL--PPK 617

Query: 370 LKVINLSDN 378
           L+ ++L+ N
Sbjct: 618 LQELDLTGN 626



 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 84/355 (23%), Positives = 149/355 (41%), Gaps = 41/355 (11%)

Query: 33  SLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLI 92
           S E V  +++     L  + +  N++E +P+ +   + L  L +  N +  LPA +    
Sbjct: 369 SNELVQLDVYPVPNYLSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQICELPARLFCNS 428

Query: 93  NLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEF 152
           +LR+L    N +   PE ++   V  +++   N + +LP           L +    L F
Sbjct: 429 SLRKLLAGHNQLARLPERLERTSV-EVLDVQHNQLLELP---------PNLLMKADSLRF 478

Query: 153 LPANFGRLTKLQILELRENQLKMLPKTMNRLTQ--LERLDLGSNEFTE--VPEVLEQLSG 208
           L A+  +L  L             P T++  T   L+ L L +N  T+  VP +L     
Sbjct: 479 LNASANKLESLP------------PATLSEETNSILQELYLTNNSLTDKCVP-LLTGHPH 525

Query: 209 LKEFWMDANRLTFIPGF-IGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQ 267
           LK   M  NRL   P   +  L++L  +D+S N ++ +   I  C  +  ++  SN ++ 
Sbjct: 526 LKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLKAIPTTIMNCRRMHTVIAHSNCIEV 585

Query: 268 LPETIGSLKNITTLKIDENQL--MYLPDSIGGLISVEELDCSFNEVEALP-SSIGQLTNL 324
            PE +  L  I  + +  N+L  + LP+++     ++ELD + N    L   ++  L N+
Sbjct: 586 FPEVM-QLPEIKCVDLSCNELSEVTLPENLPP--KLQELDLTGNPRLVLDHKTLELLNNI 642

Query: 325 RTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNR 379
           R F  D        P  G       ++ H     +  +    +  L V N  DNR
Sbjct: 643 RCFKIDQ-------PSTGDASGAPAVWSHGYTEASGVKNKLCVAALSVNNFCDNR 690



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 57/200 (28%), Positives = 85/200 (42%), Gaps = 34/200 (17%)

Query: 18  RGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQS---LHKL 74
           R E  +V  LD  H  L ++P  +     +L  L   AN++E LP    + ++   L +L
Sbjct: 446 RLERTSVEVLDVQHNQLLELPPNLLMKADSLRFLNASANKLESLPPATLSEETNSILQEL 505

Query: 75  SLPDNDLT------------------------TLPAS-IANLINLRELDVSKNGIQEFPE 109
            L +N LT                        + PAS +A L  L E+D+S N ++  P 
Sbjct: 506 YLTNNSLTDKCVPLLTGHPHLKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLKAIPT 565

Query: 110 NIKNCKVLTIVEASVNPISKLPDGFSQL--LNLTQLYLNDAFLEFLPANFGRLTKLQILE 167
            I NC+ +  V A  N I   P+   QL  +    L  N+     LP N     KLQ L+
Sbjct: 566 TIMNCRRMHTVIAHSNCIEVFPE-VMQLPEIKCVDLSCNELSEVTLPENLP--PKLQELD 622

Query: 168 LREN-QLKMLPKTMNRLTQL 186
           L  N +L +  KT+  L  +
Sbjct: 623 LTGNPRLVLDHKTLELLNNI 642



 Score = 38.9 bits (89), Expect = 0.034
 Identities = 36/139 (25%), Positives = 63/139 (45%), Gaps = 8/139 (5%)

Query: 3   TKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELP 62
           T  SL  + VP   L G    +  L  ++  L+  P       + LEE+ L  N+++ +P
Sbjct: 508 TNNSLTDKCVPL--LTGHPH-LKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLKAIP 564

Query: 63  KQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQE--FPENIKNCKVLTIV 120
             + NC+ +H +    N +   P  +  L  ++ +D+S N + E   PEN+     L  +
Sbjct: 565 TTIMNCRRMHTVIAHSNCIEVFP-EVMQLPEIKCVDLSCNELSEVTLPENLP--PKLQEL 621

Query: 121 EASVNPISKLPDGFSQLLN 139
           + + NP   L     +LLN
Sbjct: 622 DLTGNPRLVLDHKTLELLN 640


>gi|4504379 leucine-rich repeat-containing G protein-coupled
           receptor 5 [Homo sapiens]
          Length = 907

 Score =  105 bits (261), Expect = 4e-22
 Identities = 117/438 (26%), Positives = 191/438 (43%), Gaps = 68/438 (15%)

Query: 14  CRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEEL-PKQLFNCQSLH 72
           C C   +   +  +D S   L ++P  +  F   L+   L  N I +L P  L + + L 
Sbjct: 38  CHC-EPDGRMLLRVDCSDLGLSELPSNLSVFTSYLD---LSMNNISQLLPNPLPSLRFLE 93

Query: 73  KLSLPDNDLTTLP-ASIANLINLRELDVSKNGIQEFP-ENIKNCKVLTIVEASVNPISKL 130
           +L L  N LT +P  +   L +L+ L +  N ++  P E ++N + L  +    N IS +
Sbjct: 94  ELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYV 153

Query: 131 PDG-FSQLLNLTQLYLNDAFLEFLPAN-------------------------FGRLTKLQ 164
           P   FS L +L  L+L+D  L  +P                           FG L+ L 
Sbjct: 154 PPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLV 213

Query: 165 ILELRENQLKML-PKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIP 223
           +L L  N++  L  K  + L  LE LDL  N   E P  +  LS LKE    +N +  IP
Sbjct: 214 VLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIP 273

Query: 224 --GFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDL----LLSSNSLQQLPETIGSLKN 277
              F+G+   +T +    N I+ V  G S  ++L +L    L  ++ + + P+  G+  N
Sbjct: 274 EKAFVGNPSLIT-IHFYDNPIQFV--GRSAFQHLPELRTLTLNGASQITEFPDLTGT-AN 329

Query: 278 ITTLKIDENQLMYLPDSI-GGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQ 336
           + +L +   Q+  LP ++   L +++ LD S+N +E LP S      L+     HN + +
Sbjct: 330 LESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLP-SFSVCQKLQKIDLRHNEIYE 388

Query: 337 LPPEIG-----------SWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPF 385
           +  +             +W  I +  +H N   TLP        L  ++LS N L + P 
Sbjct: 389 IKVDTFQQLLSLRSLNLAWNKIAI--IHPNAFSTLP-------SLIKLDLSSNLLSSFP- 438

Query: 386 SFTKLQQLTAMWLSDNQS 403
             T L  LT + L+ N +
Sbjct: 439 -ITGLHGLTHLKLTGNHA 455


>gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens]
          Length = 277

 Score =  105 bits (261), Expect = 4e-22
 Identities = 75/196 (38%), Positives = 95/196 (48%), Gaps = 24/196 (12%)

Query: 24  VTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTT 83
           +T L  SH  L  VP  I    K LE L    NQIEELP Q+ + Q L  L+L  N L T
Sbjct: 42  ITQLVLSHNKLTMVPPNIAEL-KNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNT 100

Query: 84  LPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQL 143
           LP    +L  L  LD++ N + E                     + LP  F  L  L  L
Sbjct: 101 LPRGFGSLPALEVLDLTYNNLSE---------------------NSLPGNFFYLTTLRAL 139

Query: 144 YLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVL 203
           YL+D   E LP + G+LTKLQIL LR+N L  LPK +  LTQL+ L +  N  T +P  L
Sbjct: 140 YLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPEL 199

Query: 204 E--QLSGLKEFWMDAN 217
               L+G K+ +   N
Sbjct: 200 GNLDLTGQKQVFKAEN 215



 Score = 98.6 bits (244), Expect = 4e-20
 Identities = 59/167 (35%), Positives = 91/167 (54%), Gaps = 2/167 (1%)

Query: 65  LFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASV 124
           LF    + +L L  N LT +P +IA L NL  L+   N I+E P  I + + L  +   +
Sbjct: 36  LFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGM 95

Query: 125 NPISKLPDGFSQL--LNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNR 182
           N ++ LP GF  L  L +  L  N+     LP NF  LT L+ L L +N  ++LP  + +
Sbjct: 96  NRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGK 155

Query: 183 LTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSL 229
           LT+L+ L L  N+   +P+ + +L+ LKE  +  NRLT +P  +G+L
Sbjct: 156 LTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 202



 Score = 98.6 bits (244), Expect = 4e-20
 Identities = 55/159 (34%), Positives = 90/159 (56%), Gaps = 2/159 (1%)

Query: 228 SLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQ 287
           +L  +T L +S N + MV   I+  +NL+ L   +N +++LP  I SL+ +  L +  N+
Sbjct: 38  TLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNR 97

Query: 288 LMYLPDSIGGLISVEELDCSFNEVE--ALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWK 345
           L  LP   G L ++E LD ++N +   +LP +   LT LR      N  + LPP+IG   
Sbjct: 98  LNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLT 157

Query: 346 NITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLP 384
            + +L L  N L +LP+E+G++ +LK +++  NRL  LP
Sbjct: 158 KLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLP 196



 Score = 91.7 bits (226), Expect = 4e-18
 Identities = 64/207 (30%), Positives = 94/207 (45%), Gaps = 13/207 (6%)

Query: 228 SLKQLTYLDVSKNN--IEMVEEGIS---------TCENLQDLLLSSNSLQQLPETIGSLK 276
           SLK+L      KN   ++M + GIS         T  ++  L+LS N L  +P  I  LK
Sbjct: 4   SLKKLVEESREKNQPEVDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIAELK 63

Query: 277 NITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQ 336
           N+  L    NQ+  LP  I  L  ++ L+   N +  LP   G L  L      +N L +
Sbjct: 64  NLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSE 123

Query: 337 --LPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLT 394
             LP        +  L+L  N  E LP ++G + KL++++L DN L +LP    +L QL 
Sbjct: 124 NSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLK 183

Query: 395 AMWLSDNQSKPLIPLQKETDSETQKMV 421
            + +  N+   L P     D   QK V
Sbjct: 184 ELHIQGNRLTVLPPELGNLDLTGQKQV 210



 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 57/178 (32%), Positives = 86/178 (48%), Gaps = 5/178 (2%)

Query: 160 LTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRL 219
           L+ +  L L  N+L M+P  +  L  LE L+  +N+  E+P  +  L  LK   +  NRL
Sbjct: 39  LSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRL 98

Query: 220 TFIPGFIGSLKQLTYLDVSKNNI--EMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKN 277
             +P   GSL  L  LD++ NN+    +         L+ L LS N  + LP  IG L  
Sbjct: 99  NTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTK 158

Query: 278 ITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLT---NLRTFAADHN 332
           +  L + +N L+ LP  IG L  ++EL    N +  LP  +G L      + F A++N
Sbjct: 159 LQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAENN 216



 Score = 55.1 bits (131), Expect = 5e-07
 Identities = 38/115 (33%), Positives = 54/115 (46%), Gaps = 5/115 (4%)

Query: 24  VTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTT 83
           V  L Y++ S   +P   F +  TL  LYL  N  E LP  +     L  LSL DNDL +
Sbjct: 113 VLDLTYNNLSENSLPGNFF-YLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLIS 171

Query: 84  LPASIANLINLRELDVSKNGIQEFPENIKNCKVL---TIVEASVNP-ISKLPDGF 134
           LP  I  L  L+EL +  N +   P  + N  +     + +A  NP ++ + D F
Sbjct: 172 LPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAENNPWVTPIADQF 226


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.311    0.129    0.363 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 54,869,472
Number of Sequences: 37866
Number of extensions: 2670262
Number of successful extensions: 11405
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 157
Number of HSP's successfully gapped in prelim test: 448
Number of HSP's that attempted gapping in prelim test: 7857
Number of HSP's gapped (non-prelim): 2051
length of query: 1371
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1256
effective length of database: 13,892,928
effective search space: 17449517568
effective search space used: 17449517568
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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