Guide to the Human Genome
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Search of human proteins with 8923779

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|8923779 OTU domain containing 4 protein isoform 2 [Homo
sapiens]
         (145 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|156630992 OTU domain containing 4 protein isoform 3 [Homo sap...   296   5e-81
gi|8923779 OTU domain containing 4 protein isoform 2 [Homo sapiens]   296   5e-81
gi|40807496 OTU domain containing 4 protein isoform 1 [Homo sapi...   296   5e-81
gi|223941923 OTU domain containing 1 [Homo sapiens]                    35   0.029
gi|209977067 OTU domain containing 5 isoform c [Homo sapiens]          34   0.038
gi|209977021 OTU domain containing 5 isoform b [Homo sapiens]          34   0.038
gi|209977019 OTU domain containing 5 isoform b [Homo sapiens]          34   0.038
gi|62751964 YOD1 OTU deubiquinating enzyme 1 homolog [Homo sapiens]    34   0.038
gi|33457350 OTU domain containing 5 isoform a [Homo sapiens]           32   0.14 
gi|46409282 OTU domain containing 6A [Homo sapiens]                    32   0.19 
gi|225735593 RNA polymerase II associated protein 3 isoform 2 [H...    30   0.55 
gi|225735591 RNA polymerase II associated protein 3 isoform 1 [H...    30   0.55 
gi|157364937 OTU domain containing 6B [Homo sapiens]                   29   1.2  
gi|31377468 dedicator of cytokinesis 2 [Homo sapiens]                  29   1.6  
gi|145699133 KPL2 protein isoform 1 [Homo sapiens]                     28   2.7  
gi|149363700 syntaxin binding protein 5-like [Homo sapiens]            28   2.7  
gi|118498352 M-phase phosphoprotein 6 [Homo sapiens]                   28   2.7  
gi|21703367 Di-Ras2 [Homo sapiens]                                     28   3.5  
gi|46399200 testis-specific bromodomain protein [Homo sapiens]         27   7.9  
gi|46399198 testis-specific bromodomain protein [Homo sapiens]         27   7.9  
gi|5453708 DNA-dependent protein kinase catalytic subunit-intera...    27   7.9  

>gi|156630992 OTU domain containing 4 protein isoform 3 [Homo
           sapiens]
          Length = 1049

 Score =  296 bits (757), Expect = 5e-81
 Identities = 145/145 (100%), Positives = 145/145 (100%)

Query: 1   MACIHYLRENREKFEAFIEGSFEEYLKRLENPQEWVGQVEISALSLMYRKDFIIYREPNV 60
           MACIHYLRENREKFEAFIEGSFEEYLKRLENPQEWVGQVEISALSLMYRKDFIIYREPNV
Sbjct: 1   MACIHYLRENREKFEAFIEGSFEEYLKRLENPQEWVGQVEISALSLMYRKDFIIYREPNV 60

Query: 61  SPSQVTENNFPEKVLLCFSNGNHYDIVYPIKYKESSAMCQSLLYELLYEKVFKTDVSKIV 120
           SPSQVTENNFPEKVLLCFSNGNHYDIVYPIKYKESSAMCQSLLYELLYEKVFKTDVSKIV
Sbjct: 61  SPSQVTENNFPEKVLLCFSNGNHYDIVYPIKYKESSAMCQSLLYELLYEKVFKTDVSKIV 120

Query: 121 MELDTLEVADEDNSEISDSEDDSCK 145
           MELDTLEVADEDNSEISDSEDDSCK
Sbjct: 121 MELDTLEVADEDNSEISDSEDDSCK 145


>gi|8923779 OTU domain containing 4 protein isoform 2 [Homo sapiens]
          Length = 145

 Score =  296 bits (757), Expect = 5e-81
 Identities = 145/145 (100%), Positives = 145/145 (100%)

Query: 1   MACIHYLRENREKFEAFIEGSFEEYLKRLENPQEWVGQVEISALSLMYRKDFIIYREPNV 60
           MACIHYLRENREKFEAFIEGSFEEYLKRLENPQEWVGQVEISALSLMYRKDFIIYREPNV
Sbjct: 1   MACIHYLRENREKFEAFIEGSFEEYLKRLENPQEWVGQVEISALSLMYRKDFIIYREPNV 60

Query: 61  SPSQVTENNFPEKVLLCFSNGNHYDIVYPIKYKESSAMCQSLLYELLYEKVFKTDVSKIV 120
           SPSQVTENNFPEKVLLCFSNGNHYDIVYPIKYKESSAMCQSLLYELLYEKVFKTDVSKIV
Sbjct: 61  SPSQVTENNFPEKVLLCFSNGNHYDIVYPIKYKESSAMCQSLLYELLYEKVFKTDVSKIV 120

Query: 121 MELDTLEVADEDNSEISDSEDDSCK 145
           MELDTLEVADEDNSEISDSEDDSCK
Sbjct: 121 MELDTLEVADEDNSEISDSEDDSCK 145


>gi|40807496 OTU domain containing 4 protein isoform 1 [Homo
           sapiens]
          Length = 1048

 Score =  296 bits (757), Expect = 5e-81
 Identities = 145/145 (100%), Positives = 145/145 (100%)

Query: 1   MACIHYLRENREKFEAFIEGSFEEYLKRLENPQEWVGQVEISALSLMYRKDFIIYREPNV 60
           MACIHYLRENREKFEAFIEGSFEEYLKRLENPQEWVGQVEISALSLMYRKDFIIYREPNV
Sbjct: 1   MACIHYLRENREKFEAFIEGSFEEYLKRLENPQEWVGQVEISALSLMYRKDFIIYREPNV 60

Query: 61  SPSQVTENNFPEKVLLCFSNGNHYDIVYPIKYKESSAMCQSLLYELLYEKVFKTDVSKIV 120
           SPSQVTENNFPEKVLLCFSNGNHYDIVYPIKYKESSAMCQSLLYELLYEKVFKTDVSKIV
Sbjct: 61  SPSQVTENNFPEKVLLCFSNGNHYDIVYPIKYKESSAMCQSLLYELLYEKVFKTDVSKIV 120

Query: 121 MELDTLEVADEDNSEISDSEDDSCK 145
           MELDTLEVADEDNSEISDSEDDSCK
Sbjct: 121 MELDTLEVADEDNSEISDSEDDSCK 145


>gi|223941923 OTU domain containing 1 [Homo sapiens]
          Length = 481

 Score = 34.7 bits (78), Expect = 0.029
 Identities = 20/97 (20%), Positives = 39/97 (40%), Gaps = 8/97 (8%)

Query: 4   IHYLRENREKFEAFIEGSFEEYLKRLENPQEWVGQVEISALSLMYRKDFIIYREPNVSPS 63
           +HY+ ++ + F   IEG   E++        W G  E+ A+  M   +  +     +   
Sbjct: 344 VHYIADHLDHFSPLIEGDVGEFIIAAAQDGAWAGYPELLAMGQMLNVNIHLTTGGRLESP 403

Query: 64  QVT--------ENNFPEKVLLCFSNGNHYDIVYPIKY 92
            V+        E++    + L + +  HYD V+   Y
Sbjct: 404 TVSTMIHYLGPEDSLRPSIWLSWLSNGHYDAVFDHSY 440


>gi|209977067 OTU domain containing 5 isoform c [Homo sapiens]
          Length = 349

 Score = 34.3 bits (77), Expect = 0.038
 Identities = 20/88 (22%), Positives = 39/88 (44%), Gaps = 4/88 (4%)

Query: 3   CIHYLRENREKFEAFIEGSFEEYLKRLENPQEWVGQVEISALSLMYRKDFIIYR---EPN 59
           C+ YL +N + F  ++   F  Y+ R          +E+ A++ MY +   +Y+   EP 
Sbjct: 30  CMDYLMKNADYFSNYVTEDFTTYINRKRKNNCHGNHIEMQAMAEMYNRPVEVYQYSTEP- 88

Query: 60  VSPSQVTENNFPEKVLLCFSNGNHYDIV 87
           ++       N  E + + +    HY+ V
Sbjct: 89  INTFHGIHQNEDEPIRVSYHRNIHYNSV 116


>gi|209977021 OTU domain containing 5 isoform b [Homo sapiens]
          Length = 566

 Score = 34.3 bits (77), Expect = 0.038
 Identities = 20/88 (22%), Positives = 39/88 (44%), Gaps = 4/88 (4%)

Query: 3   CIHYLRENREKFEAFIEGSFEEYLKRLENPQEWVGQVEISALSLMYRKDFIIYR---EPN 59
           C+ YL +N + F  ++   F  Y+ R          +E+ A++ MY +   +Y+   EP 
Sbjct: 247 CMDYLMKNADYFSNYVTEDFTTYINRKRKNNCHGNHIEMQAMAEMYNRPVEVYQYSTEP- 305

Query: 60  VSPSQVTENNFPEKVLLCFSNGNHYDIV 87
           ++       N  E + + +    HY+ V
Sbjct: 306 INTFHGIHQNEDEPIRVSYHRNIHYNSV 333


>gi|209977019 OTU domain containing 5 isoform b [Homo sapiens]
          Length = 566

 Score = 34.3 bits (77), Expect = 0.038
 Identities = 20/88 (22%), Positives = 39/88 (44%), Gaps = 4/88 (4%)

Query: 3   CIHYLRENREKFEAFIEGSFEEYLKRLENPQEWVGQVEISALSLMYRKDFIIYR---EPN 59
           C+ YL +N + F  ++   F  Y+ R          +E+ A++ MY +   +Y+   EP 
Sbjct: 247 CMDYLMKNADYFSNYVTEDFTTYINRKRKNNCHGNHIEMQAMAEMYNRPVEVYQYSTEP- 305

Query: 60  VSPSQVTENNFPEKVLLCFSNGNHYDIV 87
           ++       N  E + + +    HY+ V
Sbjct: 306 INTFHGIHQNEDEPIRVSYHRNIHYNSV 333


>gi|62751964 YOD1 OTU deubiquinating enzyme 1 homolog [Homo sapiens]
          Length = 348

 Score = 34.3 bits (77), Expect = 0.038
 Identities = 20/71 (28%), Positives = 33/71 (46%)

Query: 15  EAFIEGSFEEYLKRLENPQEWVGQVEISALSLMYRKDFIIYREPNVSPSQVTENNFPEKV 74
           EA +  + +EY   ++    W G +EIS LS  Y+ +  +     V   +  E+    K 
Sbjct: 199 EAILGKTNQEYCDWIKRDDTWGGAIEISILSKFYQCEICVVDTQTVRIDRFGEDAGYTKR 258

Query: 75  LLCFSNGNHYD 85
           +L   +G HYD
Sbjct: 259 VLLIYDGIHYD 269


>gi|33457350 OTU domain containing 5 isoform a [Homo sapiens]
          Length = 571

 Score = 32.3 bits (72), Expect = 0.14
 Identities = 20/93 (21%), Positives = 39/93 (41%), Gaps = 9/93 (9%)

Query: 3   CIHYLRENREKFEAFIEGSFEEYLKRLENPQEWVGQVEISALSLMYRKDFIIYR------ 56
           C+ YL +N + F  ++   F  Y+ R          +E+ A++ MY +   +Y+      
Sbjct: 247 CMDYLMKNADYFSNYVTEDFTTYINRKRKNNCHGNHIEMQAMAEMYNRPVEVYQYSTGTS 306

Query: 57  --EPNVSPSQVTENNFPEKVLLCFSNGNHYDIV 87
             EP ++       N  E + + +    HY+ V
Sbjct: 307 AVEP-INTFHGIHQNEDEPIRVSYHRNIHYNSV 338


>gi|46409282 OTU domain containing 6A [Homo sapiens]
          Length = 288

 Score = 32.0 bits (71), Expect = 0.19
 Identities = 23/100 (23%), Positives = 44/100 (44%), Gaps = 8/100 (8%)

Query: 10  NREKFEAFIEGSFEEYLKRLENPQEWVGQVEISALSLMYRKDFIIYREPNVSPSQVTENN 69
           N E  ++F    F  Y   +     W GQ+E+ ALS + +    + +    SP+ +    
Sbjct: 191 NPETSDSFGYDDFMIYCDNIVRTTAWGGQLELRALSHVLKTPIEVIQAD--SPTLIIGEE 248

Query: 70  FPEKVLL------CFSNGNHYDIVYPIKYKESSAMCQSLL 103
           + +K ++       +S G HY+ V P++   +  +   LL
Sbjct: 249 YVKKPIILVYLRYAYSLGEHYNSVTPLEAGAAGGVLPRLL 288


>gi|225735593 RNA polymerase II associated protein 3 isoform 2 [Homo
           sapiens]
          Length = 631

 Score = 30.4 bits (67), Expect = 0.55
 Identities = 27/81 (33%), Positives = 39/81 (48%), Gaps = 6/81 (7%)

Query: 67  ENNFPEKVLLCFSNGNHYDIVYPIKYKESSAMCQ-----SLLYELLYEKVFKTDVSKIVM 121
           +N  PE+ L    NGN +      K KESS   +     + +    YE   K DV +I+ 
Sbjct: 45  QNGVPEENLPPIRNGN-FRKKKKGKAKESSKKTREENTKNRIKSYDYEAWAKLDVDRILD 103

Query: 122 ELDTLEVADEDNSEISDSEDD 142
           ELD  +   E  S+ S+SE+D
Sbjct: 104 ELDKDDSTHESLSQESESEED 124


>gi|225735591 RNA polymerase II associated protein 3 isoform 1 [Homo
           sapiens]
          Length = 665

 Score = 30.4 bits (67), Expect = 0.55
 Identities = 27/81 (33%), Positives = 39/81 (48%), Gaps = 6/81 (7%)

Query: 67  ENNFPEKVLLCFSNGNHYDIVYPIKYKESSAMCQ-----SLLYELLYEKVFKTDVSKIVM 121
           +N  PE+ L    NGN +      K KESS   +     + +    YE   K DV +I+ 
Sbjct: 45  QNGVPEENLPPIRNGN-FRKKKKGKAKESSKKTREENTKNRIKSYDYEAWAKLDVDRILD 103

Query: 122 ELDTLEVADEDNSEISDSEDD 142
           ELD  +   E  S+ S+SE+D
Sbjct: 104 ELDKDDSTHESLSQESESEED 124


>gi|157364937 OTU domain containing 6B [Homo sapiens]
          Length = 323

 Score = 29.3 bits (64), Expect = 1.2
 Identities = 19/72 (26%), Positives = 34/72 (47%), Gaps = 8/72 (11%)

Query: 22  FEEYLKRLENPQEWVGQVEISALSLMYRKDFIIYREPNVSPSQVTENNFPEKVLL----- 76
           F++Y + + N   W GQ+E+ ALS + +    I +    SP  +    + +K L+     
Sbjct: 242 FQKYCEDIVNTAAWGGQLELRALSHILQTPIEIIQAD--SPPIIVGEEYSKKPLILVYMR 299

Query: 77  -CFSNGNHYDIV 87
             +  G HY+ V
Sbjct: 300 HAYGLGEHYNSV 311


>gi|31377468 dedicator of cytokinesis 2 [Homo sapiens]
          Length = 1830

 Score = 28.9 bits (63), Expect = 1.6
 Identities = 34/124 (27%), Positives = 53/124 (42%), Gaps = 29/124 (23%)

Query: 47  MYRKDFIIYREPNVSPSQVTENNFPEKVLLC-------FSNGNHYDIVYPIKYKESSAMC 99
           ++ K FI  +E  V   + TEN  P ++ L        +  G+ +  +Y    KE     
Sbjct: 58  IFPKSFIHIKEVTVEKRRNTENIIPAEIPLAQEVTTTLWEWGSIWKQLYVASKKERFLQV 117

Query: 100 QSLLYEL-------------------LYEKV-FKTDVSKIVMELDTLEVADEDNSEISDS 139
           QS++Y+L                   L +KV  K D    ++ELD L V DED + I D 
Sbjct: 118 QSMMYDLMEWRSQLLSGTLPKDELKELKQKVTSKIDYGNKILELD-LIVRDEDGN-ILDP 175

Query: 140 EDDS 143
           ++ S
Sbjct: 176 DNTS 179


>gi|145699133 KPL2 protein isoform 1 [Homo sapiens]
          Length = 1822

 Score = 28.1 bits (61), Expect = 2.7
 Identities = 16/46 (34%), Positives = 28/46 (60%), Gaps = 3/46 (6%)

Query: 4    IHYLRENREKFEAF---IEGSFEEYLKRLENPQEWVGQVEISALSL 46
            + +LRE++    A+   I  SF+E+LKR ++ Q++V Q +    SL
Sbjct: 1046 LRHLREDQHTVLAYLYEIRTSFQEFLKRPDHKQDFVAQWQADFNSL 1091


>gi|149363700 syntaxin binding protein 5-like [Homo sapiens]
          Length = 1186

 Score = 28.1 bits (61), Expect = 2.7
 Identities = 18/63 (28%), Positives = 34/63 (53%), Gaps = 9/63 (14%)

Query: 70  FPEKVLLCFSNGNHYDIVYPIKYKESSAMCQSLLYELLYEKVFKTDVSKIVMELDTLEVA 129
           +PE ++   ++G+       IK+ ++SA+   +LY+L   KVF  +  K+     T E+ 
Sbjct: 460 YPEIIITGHADGS-------IKFWDASAITLQMLYKLKTSKVF--EKQKVGEGKQTCEIV 510

Query: 130 DED 132
           +ED
Sbjct: 511 EED 513


>gi|118498352 M-phase phosphoprotein 6 [Homo sapiens]
          Length = 160

 Score = 28.1 bits (61), Expect = 2.7
 Identities = 14/53 (26%), Positives = 29/53 (54%), Gaps = 5/53 (9%)

Query: 93  KESSAMCQSLLYELLYEKVFKTDVSKIVMELDTLEVADEDNSE-----ISDSE 140
           ++S  +C+ LLY  +  + F  +V K++++++    A+E   E     +SD E
Sbjct: 61  EQSFLLCEDLLYGRMSFRGFNPEVEKLMLQMNAKHKAEEVEDETVELDVSDEE 113


>gi|21703367 Di-Ras2 [Homo sapiens]
          Length = 199

 Score = 27.7 bits (60), Expect = 3.5
 Identities = 31/132 (23%), Positives = 60/132 (45%), Gaps = 25/132 (18%)

Query: 17  FIEGSFEE-YLKRLENPQEWVGQVEISALSLMYRKDFIIYREPNVSPSQVTE----NNFP 71
           F++G+F E Y+  +E+                YR+  +I  + ++   Q+T+    + FP
Sbjct: 27  FVKGTFRESYIPTVEDT---------------YRQ--VISCDKSICTLQITDTTGSHQFP 69

Query: 72  EKVLLCFSNGNHYDIVYPIKYKESSAMCQSLLYELLYEKVFKTDVSKIVMELDTLEVADE 131
               L  S G+ + +VY I  ++S    +  +YE + E   K DV  I + L   +  + 
Sbjct: 70  AMQRLSISKGHAFILVYSITSRQSLEELKP-IYEQICE--IKGDVESIPIMLVGNKCDES 126

Query: 132 DNSEISDSEDDS 143
            + E+  SE ++
Sbjct: 127 PSREVQSSEAEA 138


>gi|46399200 testis-specific bromodomain protein [Homo sapiens]
          Length = 947

 Score = 26.6 bits (57), Expect = 7.9
 Identities = 27/104 (25%), Positives = 43/104 (41%), Gaps = 23/104 (22%)

Query: 55  YREPNVSPSQVTENNFPEKVLLCFSNGNHYDIVYPIKYKESSAMCQSLLYELLYEKVFK- 113
           + E +V+   + EN  P+ VL    +   Y++V  +K  E    C  +L E+L +K F  
Sbjct: 235 FTEKSVALPPIKEN-MPKNVLP--DSQQQYNVVKTVKVTEQLRHCSEILKEMLAKKHFSY 291

Query: 114 ------------------TDVSKIVMELDTLEVADEDNSEISDS 139
                              DV K  M+L T++    DN E  D+
Sbjct: 292 AWPFYNPVDVNALGLHNYYDVVKNPMDLGTIK-EKMDNQEYKDA 334


>gi|46399198 testis-specific bromodomain protein [Homo sapiens]
          Length = 947

 Score = 26.6 bits (57), Expect = 7.9
 Identities = 27/104 (25%), Positives = 43/104 (41%), Gaps = 23/104 (22%)

Query: 55  YREPNVSPSQVTENNFPEKVLLCFSNGNHYDIVYPIKYKESSAMCQSLLYELLYEKVFK- 113
           + E +V+   + EN  P+ VL    +   Y++V  +K  E    C  +L E+L +K F  
Sbjct: 235 FTEKSVALPPIKEN-MPKNVLP--DSQQQYNVVKTVKVTEQLRHCSEILKEMLAKKHFSY 291

Query: 114 ------------------TDVSKIVMELDTLEVADEDNSEISDS 139
                              DV K  M+L T++    DN E  D+
Sbjct: 292 AWPFYNPVDVNALGLHNYYDVVKNPMDLGTIK-EKMDNQEYKDA 334


>gi|5453708 DNA-dependent protein kinase catalytic
           subunit-interacting protein 2 [Homo sapiens]
          Length = 187

 Score = 26.6 bits (57), Expect = 7.9
 Identities = 17/68 (25%), Positives = 31/68 (45%), Gaps = 2/68 (2%)

Query: 48  YRKDFIIYREPN--VSPSQVTENNFPEKVLLCFSNGNHYDIVYPIKYKESSAMCQSLLYE 105
           YRK  I++   +  +   ++ EN F E+++  FS     ++ +       S +C+S   E
Sbjct: 46  YRKSPIVHVPMSLIIQMPELRENPFKERIVAAFSEDGEGNLTFNDFVDMFSVLCESAPRE 105

Query: 106 LLYEKVFK 113
           L     FK
Sbjct: 106 LKANYAFK 113


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.134    0.383 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 5,272,285
Number of Sequences: 37866
Number of extensions: 206573
Number of successful extensions: 656
Number of sequences better than 10.0: 21
Number of HSP's better than 10.0 without gapping: 12
Number of HSP's successfully gapped in prelim test: 9
Number of HSP's that attempted gapping in prelim test: 643
Number of HSP's gapped (non-prelim): 22
length of query: 145
length of database: 18,247,518
effective HSP length: 92
effective length of query: 53
effective length of database: 14,763,846
effective search space: 782483838
effective search space used: 782483838
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 57 (26.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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