Search of human proteins with 8923458

Search of human proteins with 8923458

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|8923458 COMM domain containing 8 [Homo sapiens]
         (183 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|8923458 COMM domain containing 8 [Homo sapiens]                    365   e-102
gi|45333906 COMM domain containing 6 isoform b [Homo sapiens]          41   7e-04
gi|156416007 COMM domain containing 9 isoform 2 [Homo sapiens]         38   0.004
gi|156416005 COMM domain containing 9 isoform 1 [Homo sapiens]         38   0.004
gi|21361661 COMM domain containing 4 [Homo sapiens]                    38   0.004
gi|45333909 COMM domain containing 6 isoform a [Homo sapiens]          38   0.006
gi|38570058 hypothetical protein LOC80129 [Homo sapiens]               33   0.18 
gi|45545435 COMM domain containing 2 [Homo sapiens]                    32   0.23 
gi|71773329 annexin VI isoform 1 [Homo sapiens]                        32   0.30 
gi|117968420 NUF2, NDC80 kinetochore complex component [Homo sap...    32   0.30 
gi|117968353 NUF2, NDC80 kinetochore complex component [Homo sap...    32   0.30 
gi|116008194 myosin light chain kinase isoform 3A [Homo sapiens]       32   0.40 
gi|116008192 myosin light chain kinase isoform 1 [Homo sapiens]        32   0.40 
gi|116008190 myosin light chain kinase isoform 3B [Homo sapiens]       32   0.40 
gi|116008188 myosin light chain kinase isoform 2 [Homo sapiens]        32   0.40 
gi|47778940 C-type lectin, superfamily member 13 [Homo sapiens]        32   0.40 
gi|38327558 guanylate binding protein 2, interferon-inducible [H...    32   0.40 
gi|189011592 amyotrophic lateral sclerosis 2 (juvenile) chromoso...    32   0.40 
gi|189011586 amyotrophic lateral sclerosis 2 (juvenile) chromoso...    32   0.40 
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]                   30   0.89 
gi|5032013 kinesin family member 20A [Homo sapiens]                    30   1.2  
gi|30795212 insulin-like growth factor 2 mRNA binding protein 3 ...    30   1.2  
gi|33188443 microfilament and actin filament cross-linker protei...    30   1.2  
gi|33188445 microfilament and actin filament cross-linker protei...    30   1.2  
gi|187936946 hypothetical protein LOC84140 [Homo sapiens]              30   1.2  
gi|10864047 epidermal growth factor receptor pathway substrate 1...    30   1.2  
gi|166706903 guanylate binding protein 1, interferon-inducible, ...    30   1.5  
gi|71773415 annexin VI isoform 2 [Homo sapiens]                        30   1.5  
gi|58530840 desmoplakin isoform I [Homo sapiens]                       29   2.0  
gi|39725717 coiled-coil domain containing 141 [Homo sapiens]           29   2.0  

>gi|8923458 COMM domain containing 8 [Homo sapiens]
          Length = 183

 Score =  365 bits (938), Expect = e-102
 Identities = 183/183 (100%), Positives = 183/183 (100%)

Query: 1   MEPEEGTPLWRLQKLPAELGPQLLHKIIDGICGRAYPVYQDYHTVWESEEWMHVLEDIAK 60
           MEPEEGTPLWRLQKLPAELGPQLLHKIIDGICGRAYPVYQDYHTVWESEEWMHVLEDIAK
Sbjct: 1   MEPEEGTPLWRLQKLPAELGPQLLHKIIDGICGRAYPVYQDYHTVWESEEWMHVLEDIAK 60

Query: 61  FFKAIVGKNLPDEEIFQQLNQLNSLHQETIMKCVKSRKDEIKQALSREIVAISSAQLQDF 120
           FFKAIVGKNLPDEEIFQQLNQLNSLHQETIMKCVKSRKDEIKQALSREIVAISSAQLQDF
Sbjct: 61  FFKAIVGKNLPDEEIFQQLNQLNSLHQETIMKCVKSRKDEIKQALSREIVAISSAQLQDF 120

Query: 121 DWQVKLALSSDKIAALRMPLLSLHLDVKENGEVKPYSIEMSREELQNLIQSLEAANKVVL 180
           DWQVKLALSSDKIAALRMPLLSLHLDVKENGEVKPYSIEMSREELQNLIQSLEAANKVVL
Sbjct: 121 DWQVKLALSSDKIAALRMPLLSLHLDVKENGEVKPYSIEMSREELQNLIQSLEAANKVVL 180

Query: 181 QLK 183
           QLK
Sbjct: 181 QLK 183


>gi|45333906 COMM domain containing 6 isoform b [Homo sapiens]
          Length = 85

 Score = 40.8 bits (94), Expect = 7e-04
 Identities = 21/65 (32%), Positives = 38/65 (58%), Gaps = 1/65 (1%)

Query: 116 QLQDFDWQVKLALSSDKIAALRMPLLSLHLDVKE-NGEVKPYSIEMSREELQNLIQSLEA 174
           QL DF W++ +A+SSD   +L+ P +++ L V + +G+VK    EM+  + QN  +  + 
Sbjct: 18  QLVDFQWKLGMAVSSDTCRSLKYPYVAVMLKVADHSGQVKTKCFEMTIPQFQNFYRQFKE 77

Query: 175 ANKVV 179
              V+
Sbjct: 78  IAAVI 82


>gi|156416007 COMM domain containing 9 isoform 2 [Homo sapiens]
          Length = 156

 Score = 38.1 bits (87), Expect = 0.004
 Identities = 19/68 (27%), Positives = 36/68 (52%), Gaps = 7/68 (10%)

Query: 112 ISSAQLQDFDWQVKLALSSDKIAALRMPLLSLHLDVKEN-------GEVKPYSIEMSREE 164
           IS  +L D DW+V +  SSD I+ + +P   L + ++E+         +   ++E+S+E 
Sbjct: 76  ISLPRLVDLDWRVDIKTSSDSISRMAVPTCLLQMKIQEDPSLCGDKPSISAVTVELSKET 135

Query: 165 LQNLIQSL 172
           L  ++  L
Sbjct: 136 LDTMLDGL 143


>gi|156416005 COMM domain containing 9 isoform 1 [Homo sapiens]
          Length = 198

 Score = 38.1 bits (87), Expect = 0.004
 Identities = 19/68 (27%), Positives = 36/68 (52%), Gaps = 7/68 (10%)

Query: 112 ISSAQLQDFDWQVKLALSSDKIAALRMPLLSLHLDVKEN-------GEVKPYSIEMSREE 164
           IS  +L D DW+V +  SSD I+ + +P   L + ++E+         +   ++E+S+E 
Sbjct: 118 ISLPRLVDLDWRVDIKTSSDSISRMAVPTCLLQMKIQEDPSLCGDKPSISAVTVELSKET 177

Query: 165 LQNLIQSL 172
           L  ++  L
Sbjct: 178 LDTMLDGL 185


>gi|21361661 COMM domain containing 4 [Homo sapiens]
          Length = 199

 Score = 38.1 bits (87), Expect = 0.004
 Identities = 30/131 (22%), Positives = 65/131 (49%), Gaps = 9/131 (6%)

Query: 54  VLEDIAKFFKAIVGKNLPDEEIFQQLNQLNSLHQETIMKCVKSRKDEIKQALSREIVAIS 113
           +L   AK   ++ G++L  E   QQL  L   H  ++ +C + ++  +++ L   + ++ 
Sbjct: 75  ILSSAAKH--SVDGESLSSE--LQQLG-LPKEHAASLCRCYEEKQSPLQKHL--RVCSLR 127

Query: 114 SAQLQDFDWQVKLALSSDKIAALRMPLLSLHLDV--KENGEVKPYSIEMSREELQNLIQS 171
             +L    W+V   LSS  + ++  P++ L L+V        +P ++ +S ++ Q L+  
Sbjct: 128 MNRLAGVGWRVDYTLSSSLLQSVEEPMVHLRLEVAAAPGTPAQPVAMSLSADKFQVLLAE 187

Query: 172 LEAANKVVLQL 182
           L+ A  ++  L
Sbjct: 188 LKQAQTLMSSL 198


>gi|45333909 COMM domain containing 6 isoform a [Homo sapiens]
          Length = 98

 Score = 37.7 bits (86), Expect = 0.006
 Identities = 24/72 (33%), Positives = 41/72 (56%), Gaps = 4/72 (5%)

Query: 116 QLQDFDWQVKLALSSDKIAALRMPLLSLHLDVKE-NGEVKPYSIEMSREELQNLI---QS 171
           QL DF W++ +A+SSD   +L+ P +++ L V + +G+VK    EM+  + Q  +    S
Sbjct: 18  QLVDFQWKLGMAVSSDTCRSLKYPYVAVMLKVADHSGQVKTKCFEMTIPQFQPQLLATSS 77

Query: 172 LEAANKVVLQLK 183
           L +A+    Q K
Sbjct: 78  LLSASNFYRQFK 89


>gi|38570058 hypothetical protein LOC80129 [Homo sapiens]
          Length = 715

 Score = 32.7 bits (73), Expect = 0.18
 Identities = 28/110 (25%), Positives = 48/110 (43%), Gaps = 2/110 (1%)

Query: 73  EEIFQQLNQLNSLHQETIMKCVKSRKDEIKQALSREIVAISSAQLQDFDWQVKLALSSDK 132
           E + ++LN    LH E  +K   +  +E+K     +  AI          +     +  K
Sbjct: 543 ERLQKELNTCRDLHTE--LKAKLADTNELKIKTLEQTKAIEDLNKSRDQLEKMKEKAEKK 600

Query: 133 IAALRMPLLSLHLDVKENGEVKPYSIEMSREELQNLIQSLEAANKVVLQL 182
           + +++  L +   + KEN E     IE+   E++ L +SLE A K   QL
Sbjct: 601 LMSVKSELDTTEHEAKENKERARNMIEVVTSEMKTLKKSLEEAEKREKQL 650



 Score = 26.9 bits (58), Expect = 9.8
 Identities = 35/146 (23%), Positives = 70/146 (47%), Gaps = 11/146 (7%)

Query: 39  YQDYHTVWESEEWMHVLEDIAKFFKAIVGKNLPDEEIFQ-QLNQLNS--LHQETIMKCVK 95
           Y     V  + E ++   ++A+  ++ +   L   E  Q +L  L S  L +E   + +K
Sbjct: 22  YDHLSEVPVTREQLNHYRNVAQNARSELAATLVKFECAQSELQDLRSKMLSKEVSCQELK 81

Query: 96  SRKDEIKQALSREIVAISSAQ--LQDFDWQVKLALSSDKIAALRMPLLSLHLDVKENGEV 153
           +  +  K+  +R+   ++S +  +Q+ + +   ALS+ KI       ++ H  +KEN E+
Sbjct: 82  AEMESYKENNARKSSLLTSLRDRVQELE-EESAALSTSKIRTE----ITAHAAIKENQEL 136

Query: 154 KPYSIEMSREELQNLIQSLEAANKVV 179
           K   +E++ E+LQ   +  E   K V
Sbjct: 137 KKKVVELN-EKLQKCSKENEENKKQV 161


>gi|45545435 COMM domain containing 2 [Homo sapiens]
          Length = 199

 Score = 32.3 bits (72), Expect = 0.23
 Identities = 22/95 (23%), Positives = 46/95 (48%), Gaps = 6/95 (6%)

Query: 81  QLNSLHQETIMKCVKSRKDEIKQALSREIVAISSAQLQDFDWQVKLALSSDKIAALRMPL 140
           +LN L    +++     + EI+  LS   +A S     + +W++ + L+S  +     P 
Sbjct: 94  ELNKL----LLQLYLDNRKEIRTILSE--LAPSLPSYHNLEWRLDVQLASRSLRQQIKPA 147

Query: 141 LSLHLDVKENGEVKPYSIEMSREELQNLIQSLEAA 175
           +++ L + +NG+     ++     L +L+Q LE A
Sbjct: 148 VTIKLHLNQNGDHNTKVLQTDPATLLHLVQQLEQA 182


>gi|71773329 annexin VI isoform 1 [Homo sapiens]
          Length = 673

 Score = 32.0 bits (71), Expect = 0.30
 Identities = 23/69 (33%), Positives = 37/69 (53%), Gaps = 3/69 (4%)

Query: 108 EIVAISSAQLQDFDWQVKLALSSDKIAALRMPLLSLHLDVKENGEVKPYSIEMSREELQN 167
           EI AI+ A  +D+   ++ ALSSD     R  L+SL    +E G     +++ +RE+ Q 
Sbjct: 469 EIRAINEAYKEDYHKSLEDALSSDTSGHFRRILISLATGHREEG---GENLDQAREDAQV 525

Query: 168 LIQSLEAAN 176
             + LE A+
Sbjct: 526 AAEILEIAD 534


>gi|117968420 NUF2, NDC80 kinetochore complex component [Homo
           sapiens]
          Length = 464

 Score = 32.0 bits (71), Expect = 0.30
 Identities = 28/126 (22%), Positives = 64/126 (50%), Gaps = 24/126 (19%)

Query: 78  QLNQLNSLHQETIMKCVK------SRKDEIKQALSREIVAISSAQLQDFDWQV------- 124
           ++ QLN+ HQE +MK  +        ++E KQ LS  I  +  +  QDF  +        
Sbjct: 151 KMQQLNAAHQEALMKLERLDSVPVEEQEEFKQ-LSDGIQELQQSLNQDFHQKTIVLQEGN 209

Query: 125 -----KLALSSDKIAALRMPLLSLHLDVKENGEVK----PYSIEMSREELQNLIQSLEAA 175
                 ++  + ++  L++ ++SL  +++E+ + K    P  ++  +E++++ +Q L+ A
Sbjct: 210 SQKKSNISEKTKRLNELKLSVVSLK-EIQESLKTKIVDSPEKLKNYKEKMKDTVQKLKNA 268

Query: 176 NKVVLQ 181
            + V++
Sbjct: 269 RQEVVE 274


>gi|117968353 NUF2, NDC80 kinetochore complex component [Homo
           sapiens]
          Length = 464

 Score = 32.0 bits (71), Expect = 0.30
 Identities = 28/126 (22%), Positives = 64/126 (50%), Gaps = 24/126 (19%)

Query: 78  QLNQLNSLHQETIMKCVK------SRKDEIKQALSREIVAISSAQLQDFDWQV------- 124
           ++ QLN+ HQE +MK  +        ++E KQ LS  I  +  +  QDF  +        
Sbjct: 151 KMQQLNAAHQEALMKLERLDSVPVEEQEEFKQ-LSDGIQELQQSLNQDFHQKTIVLQEGN 209

Query: 125 -----KLALSSDKIAALRMPLLSLHLDVKENGEVK----PYSIEMSREELQNLIQSLEAA 175
                 ++  + ++  L++ ++SL  +++E+ + K    P  ++  +E++++ +Q L+ A
Sbjct: 210 SQKKSNISEKTKRLNELKLSVVSLK-EIQESLKTKIVDSPEKLKNYKEKMKDTVQKLKNA 268

Query: 176 NKVVLQ 181
            + V++
Sbjct: 269 RQEVVE 274


>gi|116008194 myosin light chain kinase isoform 3A [Homo sapiens]
          Length = 1863

 Score = 31.6 bits (70), Expect = 0.40
 Identities = 17/52 (32%), Positives = 30/52 (57%), Gaps = 2/52 (3%)

Query: 60   KFFKAIVGKNLPDEEIFQQLNQLNSLHQETIMKCVKSRKDEIKQALSREIVA 111
            KFFKA   K    E I Q+++ +N LH   +++CV + +++    +  EIV+
Sbjct: 1493 KFFKAYSAKE--KENIRQEISIMNCLHHPKLVQCVDAFEEKANIVMVLEIVS 1542


>gi|116008192 myosin light chain kinase isoform 1 [Homo sapiens]
          Length = 1914

 Score = 31.6 bits (70), Expect = 0.40
 Identities = 17/52 (32%), Positives = 30/52 (57%), Gaps = 2/52 (3%)

Query: 60   KFFKAIVGKNLPDEEIFQQLNQLNSLHQETIMKCVKSRKDEIKQALSREIVA 111
            KFFKA   K    E I Q+++ +N LH   +++CV + +++    +  EIV+
Sbjct: 1493 KFFKAYSAKE--KENIRQEISIMNCLHHPKLVQCVDAFEEKANIVMVLEIVS 1542


>gi|116008190 myosin light chain kinase isoform 3B [Homo sapiens]
          Length = 1794

 Score = 31.6 bits (70), Expect = 0.40
 Identities = 17/52 (32%), Positives = 30/52 (57%), Gaps = 2/52 (3%)

Query: 60   KFFKAIVGKNLPDEEIFQQLNQLNSLHQETIMKCVKSRKDEIKQALSREIVA 111
            KFFKA   K    E I Q+++ +N LH   +++CV + +++    +  EIV+
Sbjct: 1424 KFFKAYSAKE--KENIRQEISIMNCLHHPKLVQCVDAFEEKANIVMVLEIVS 1473


>gi|116008188 myosin light chain kinase isoform 2 [Homo sapiens]
          Length = 1845

 Score = 31.6 bits (70), Expect = 0.40
 Identities = 17/52 (32%), Positives = 30/52 (57%), Gaps = 2/52 (3%)

Query: 60   KFFKAIVGKNLPDEEIFQQLNQLNSLHQETIMKCVKSRKDEIKQALSREIVA 111
            KFFKA   K    E I Q+++ +N LH   +++CV + +++    +  EIV+
Sbjct: 1424 KFFKAYSAKE--KENIRQEISIMNCLHHPKLVQCVDAFEEKANIVMVLEIVS 1473


>gi|47778940 C-type lectin, superfamily member 13 [Homo sapiens]
          Length = 589

 Score = 31.6 bits (70), Expect = 0.40
 Identities = 35/110 (31%), Positives = 56/110 (50%), Gaps = 9/110 (8%)

Query: 72  DEEIFQQLNQL-NSLHQETIMKCVKSRKDEIKQALSREIVAISSAQLQDFDWQVKLALSS 130
           D   FQ LN L +SL   +I   V SR   ++ A S   + + +A L+  + Q +LA SS
Sbjct: 191 DALTFQTLNFLKSSLENTSIELHVLSRG--LENANSE--IQMLNASLETANTQAQLANSS 246

Query: 131 DKIAALRMPLLSLHLD----VKENGEVKPYSIEMSREELQNLIQSLEAAN 176
            K A   + +L  HLD    ++   +V   S+E +  E+Q L ++L+  N
Sbjct: 247 LKNANAEIYVLRGHLDSVNDLRTQNQVLRNSLEGANAEIQGLKENLQNTN 296


>gi|38327558 guanylate binding protein 2, interferon-inducible [Homo
           sapiens]
          Length = 591

 Score = 31.6 bits (70), Expect = 0.40
 Identities = 27/99 (27%), Positives = 44/99 (44%)

Query: 70  LPDEEIFQQLNQLNSLHQETIMKCVKSRKDEIKQALSREIVAISSAQLQDFDWQVKLALS 129
           LP E + + L+      +E I   +K+   ++ Q   R++ A   A+  DF  Q   A S
Sbjct: 343 LPTETLQELLDLHRDSEREAIEVFMKNSFKDVDQMFQRKLGAQLEARRDDFCKQNSKASS 402

Query: 130 SDKIAALRMPLLSLHLDVKENGEVKPYSIEMSREELQNL 168
              +A L+     L  DVK+    KP    +  ++LQ L
Sbjct: 403 DCCMALLQDIFGPLEEDVKQGTFSKPGGYRLFTQKLQEL 441


>gi|189011592 amyotrophic lateral sclerosis 2 (juvenile) chromosome
           region, candidate 12 isoform b [Homo sapiens]
          Length = 422

 Score = 31.6 bits (70), Expect = 0.40
 Identities = 28/99 (28%), Positives = 48/99 (48%), Gaps = 15/99 (15%)

Query: 46  WESEEWMHVLEDIAKFFKAIVGKNLPDE--EIFQQLNQLNSLHQETIMKCVKSRKD---- 99
           WESE     + D  +F +  +  +L ++  E+   + Q+N  HQ    K + S  D    
Sbjct: 111 WESE-----IPDKGRFSRTNIISDLEEQISELTAIIEQMNRDHQSA-QKLLSSEMDLRCA 164

Query: 100 EIKQAL---SREIVAISSAQLQDFDWQVKLALSSDKIAA 135
           E+KQ     +RE+     A+L + +   K AL ++K+AA
Sbjct: 165 EMKQNFENKNRELKEAHEAELSELENNYKAALKAEKLAA 203


>gi|189011586 amyotrophic lateral sclerosis 2 (juvenile) chromosome
           region, candidate 12 isoform a [Homo sapiens]
          Length = 445

 Score = 31.6 bits (70), Expect = 0.40
 Identities = 28/99 (28%), Positives = 48/99 (48%), Gaps = 15/99 (15%)

Query: 46  WESEEWMHVLEDIAKFFKAIVGKNLPDE--EIFQQLNQLNSLHQETIMKCVKSRKD---- 99
           WESE     + D  +F +  +  +L ++  E+   + Q+N  HQ    K + S  D    
Sbjct: 111 WESE-----IPDKGRFSRTNIISDLEEQISELTAIIEQMNRDHQSA-QKLLSSEMDLRCA 164

Query: 100 EIKQAL---SREIVAISSAQLQDFDWQVKLALSSDKIAA 135
           E+KQ     +RE+     A+L + +   K AL ++K+AA
Sbjct: 165 EMKQNFENKNRELKEAHEAELSELENNYKAALKAEKLAA 203


>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
          Length = 1417

 Score = 30.4 bits (67), Expect = 0.89
 Identities = 27/106 (25%), Positives = 53/106 (50%), Gaps = 4/106 (3%)

Query: 70  LPDEEIFQQLNQLNSLHQETIMKCVKSRKDEIKQALSREIVAISSAQLQDFDWQVKLALS 129
           L  EE+ ++ +  + L  E   KC  S+   +++ L  +IVA SS   ++ + + +L   
Sbjct: 673 LIQEELLEKASNSSKLESEMTKKC--SQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEK 730

Query: 130 SDKIAALRMPLLSLHLDVKENGE-VKPYSIEMSREELQNLIQSLEA 174
           ++KI +L   + + H  +    E  K   +E   +E++  I+ LEA
Sbjct: 731 NEKIRSLETNINTEHEKICLAFEKAKKIHLE-QHKEMEKQIERLEA 775


>gi|5032013 kinesin family member 20A [Homo sapiens]
          Length = 890

 Score = 30.0 bits (66), Expect = 1.2
 Identities = 37/146 (25%), Positives = 64/146 (43%), Gaps = 25/146 (17%)

Query: 49  EEWMHVL-EDIAKFFKAIVGKNLPDEEIFQQLNQLNSLHQETIMKCVKSRKDEIKQALSR 107
           EE +++L E +  F++  +      +E  +++ +L +L QE   + V  ++   + AL R
Sbjct: 623 EEKLNILKESLTSFYQEEI------QERDEKIEELEALLQEARQQSVAHQQSGSELALRR 676

Query: 108 EIVAISSAQLQDFDWQVKLALSSDKIAALRMPLLSLH----------------LDVKENG 151
                +SA  Q    +VK  L   K A L      LH                +DV +  
Sbjct: 677 SQRLAASASTQQLQ-EVKAKLQQCK-AELNSTTEELHKYQKMLEPPPSAKPFTIDVDKKL 734

Query: 152 EVKPYSIEMSREELQNLIQSLEAANK 177
           E    +I + R ELQ L +SL++A +
Sbjct: 735 EEGQKNIRLLRTELQKLGESLQSAER 760


>gi|30795212 insulin-like growth factor 2 mRNA binding protein 3
           [Homo sapiens]
          Length = 579

 Score = 30.0 bits (66), Expect = 1.2
 Identities = 18/66 (27%), Positives = 37/66 (56%), Gaps = 6/66 (9%)

Query: 75  IFQQLNQLNSLHQETIMKCVKSRKDEIKQALSREIVAISSAQLQDFDWQVKLALSSDKIA 134
           + +   Q+N+  +  ++    S KD+ +QAL +    ++  QL++F   +K+A   D++A
Sbjct: 106 VVESCEQVNTDSETAVVNVTYSSKDQARQALDK----LNGFQLENF--TLKVAYIPDEMA 159

Query: 135 ALRMPL 140
           A + PL
Sbjct: 160 AQQNPL 165


>gi|33188443 microfilament and actin filament cross-linker protein
            isoform b [Homo sapiens]
          Length = 5938

 Score = 30.0 bits (66), Expect = 1.2
 Identities = 26/134 (19%), Positives = 64/134 (47%), Gaps = 5/134 (3%)

Query: 55   LEDIAKFFKAIVGKNLPDEEIFQQLNQLNSLHQETIMKCVKSRKDEIKQALSR-EIVAIS 113
            L+ +A+    I G+  PD    Q+       H +++   +  R   +++A+++ + V  S
Sbjct: 2496 LQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQES 2555

Query: 114  SAQLQDFDWQVKLALSSDKIAALRMPL----LSLHLDVKENGEVKPYSIEMSREELQNLI 169
               L     +V+  L   ++++L   +    L+ ++ +K++   +  S+E +RE +   +
Sbjct: 2556 LESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFM 2615

Query: 170  QSLEAANKVVLQLK 183
            ++ ++    VLQ K
Sbjct: 2616 ETADSTTAAVLQGK 2629


>gi|33188445 microfilament and actin filament cross-linker protein
            isoform a [Homo sapiens]
          Length = 5430

 Score = 30.0 bits (66), Expect = 1.2
 Identities = 26/134 (19%), Positives = 64/134 (47%), Gaps = 5/134 (3%)

Query: 55   LEDIAKFFKAIVGKNLPDEEIFQQLNQLNSLHQETIMKCVKSRKDEIKQALSR-EIVAIS 113
            L+ +A+    I G+  PD    Q+       H +++   +  R   +++A+++ + V  S
Sbjct: 1994 LQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQES 2053

Query: 114  SAQLQDFDWQVKLALSSDKIAALRMPL----LSLHLDVKENGEVKPYSIEMSREELQNLI 169
               L     +V+  L   ++++L   +    L+ ++ +K++   +  S+E +RE +   +
Sbjct: 2054 LESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFM 2113

Query: 170  QSLEAANKVVLQLK 183
            ++ ++    VLQ K
Sbjct: 2114 ETADSTTAAVLQGK 2127


>gi|187936946 hypothetical protein LOC84140 [Homo sapiens]
          Length = 660

 Score = 30.0 bits (66), Expect = 1.2
 Identities = 29/120 (24%), Positives = 49/120 (40%), Gaps = 12/120 (10%)

Query: 69  NLPD-----EEIFQQLNQLNSLHQETIMKCVKSRKDEIKQALSREIVAISSAQLQDFDWQ 123
           N PD     EE F+++ +L + H ET+ K  K  +D++     + +V I    L D    
Sbjct: 84  NFPDIHHSNEEYFKKVEELKAAHIETMAKLEKMYQDKLHLKEVQPVV-IREDSLSDSSRS 142

Query: 124 VKLALSSDKIAALRMPLLSLHLDVKENGEVKPYSIEMSREELQNLIQSLEAANKVVLQLK 183
           V    S   ++      L       + G+     +  S EEL NL +     N+++   K
Sbjct: 143 VSEKNSYHPVS------LMTSFSEPDLGQSSSLYVSSSEEELPNLEKEYPRKNRMMTYAK 196


>gi|10864047 epidermal growth factor receptor pathway substrate
           15-like 1 [Homo sapiens]
          Length = 864

 Score = 30.0 bits (66), Expect = 1.2
 Identities = 18/52 (34%), Positives = 28/52 (53%)

Query: 56  EDIAKFFKAIVGKNLPDEEIFQQLNQLNSLHQETIMKCVKSRKDEIKQALSR 107
           ED     K+ + +   +E   +Q  Q   +  ETI+K +KS +DEI QA S+
Sbjct: 495 EDDLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSK 546


>gi|166706903 guanylate binding protein 1, interferon-inducible,
           67kDa [Homo sapiens]
          Length = 592

 Score = 29.6 bits (65), Expect = 1.5
 Identities = 27/100 (27%), Positives = 47/100 (47%), Gaps = 2/100 (2%)

Query: 70  LPDEEIFQQLNQLNSLHQETIMKCVKSRKDEIKQALSREIVAISSAQLQDFDWQVKLALS 129
           LP E + + L+      +E I   ++S   ++     +E+ A    +  DF  Q + A S
Sbjct: 345 LPTETLQELLDLHRDSEREAIEVFIRSSFKDVDHLFQKELAAQLEKKRDDFCKQNQEA-S 403

Query: 130 SDKIAALRMPLLS-LHLDVKENGEVKPYSIEMSREELQNL 168
           SD+ +AL   + S L  +VK     KP    +  ++LQ+L
Sbjct: 404 SDRCSALLQVIFSPLEEEVKAGIYSKPGGYRLFVQKLQDL 443


>gi|71773415 annexin VI isoform 2 [Homo sapiens]
          Length = 667

 Score = 29.6 bits (65), Expect = 1.5
 Identities = 20/61 (32%), Positives = 33/61 (54%), Gaps = 3/61 (4%)

Query: 108 EIVAISSAQLQDFDWQVKLALSSDKIAALRMPLLSLHLDVKENGEVKPYSIEMSREELQN 167
           EI AI+ A  +D+   ++ ALSSD     R  L+SL    +E G     +++ +RE+ Q 
Sbjct: 469 EIRAINEAYKEDYHKSLEDALSSDTSGHFRRILISLATGHREEG---GENLDQAREDAQE 525

Query: 168 L 168
           +
Sbjct: 526 I 526


>gi|58530840 desmoplakin isoform I [Homo sapiens]
          Length = 2871

 Score = 29.3 bits (64), Expect = 2.0
 Identities = 33/143 (23%), Positives = 64/143 (44%), Gaps = 15/143 (10%)

Query: 41   DYHTVWESEEWMHVLEDIAKFFKAIVGKNLPDEEIFQQLNQLNSLHQETIMKCVKSRK-- 98
            DY  V  S+E     +DI +F  ++    L  +++ ++LN+L     E   K  K  +  
Sbjct: 1541 DYERV--SQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEEL 1598

Query: 99   DEIKQALSREIVAISSAQLQDFDWQVKLALSSDKIAALRMPLLSLHLDVKENGEVKPYSI 158
            + ++++L  + + I++   Q     +    S D +   R  +L  HL  K+         
Sbjct: 1599 EGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQR-DVLDGHLREKQR-------- 1649

Query: 159  EMSREELQNLIQSLEAANKVVLQ 181
              ++EEL+ L   +EA  + +LQ
Sbjct: 1650 --TQEELRRLSSEVEALRRQLLQ 1670


>gi|39725717 coiled-coil domain containing 141 [Homo sapiens]
          Length = 875

 Score = 29.3 bits (64), Expect = 2.0
 Identities = 37/134 (27%), Positives = 63/134 (47%), Gaps = 19/134 (14%)

Query: 58  IAKFFKAIVGKNLPDEEIFQQLNQLNSLHQ----------ETIMKCVKSR--KDEIKQAL 105
           I K  + + G+  P +E  QQL  L   HQ          + + K V+    K+E+ + +
Sbjct: 169 IMKESEELTGRGAPVKEKSQQLKDLIHFHQKQKERIQDYEDILYKVVQFHQVKEELGRLI 228

Query: 106 -SREIVAISS-AQLQD-FDWQVKLALSSDKIAA---LRMPLLSLHLDVKENGEVKPYSIE 159
            SRE+  +    +L D  D Q+ L  S +K A    L    LSL +D+  + + +P+   
Sbjct: 229 KSRELEFVEQPKELGDAHDVQIHLRCSQEKQARVDHLHRLALSLGVDIISSVQ-RPHCSN 287

Query: 160 MSREELQNLIQSLE 173
           +S + LQ  ++ LE
Sbjct: 288 VSAKNLQQQLELLE 301


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.133    0.384 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 6,631,373
Number of Sequences: 37866
Number of extensions: 265443
Number of successful extensions: 960
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 23
Number of HSP's successfully gapped in prelim test: 40
Number of HSP's that attempted gapping in prelim test: 930
Number of HSP's gapped (non-prelim): 70
length of query: 183
length of database: 18,247,518
effective HSP length: 96
effective length of query: 87
effective length of database: 14,612,382
effective search space: 1271277234
effective search space used: 1271277234
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 58 (26.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.