Guide to the Human Genome
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Search of human proteins with 8923398

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|8923398 Ly1 antibody reactive homolog [Homo sapiens]
         (379 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|224591430 Ly1 antibody reactive homolog [Homo sapiens]             773   0.0  
gi|8923398 Ly1 antibody reactive homolog [Homo sapiens]               773   0.0  
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]            67   3e-11
gi|239508778 PREDICTED: hypothetical protein, partial [Homo sapi...    64   3e-10
gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]            61   2e-09
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ...    57   3e-08
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom...    57   4e-08
gi|7661950 SH2 domain binding protein 1 [Homo sapiens]                 57   4e-08
gi|153945728 microtubule-associated protein 1B [Homo sapiens]          55   1e-07
gi|27734775 hypothetical protein LOC286499 [Homo sapiens]              54   2e-07
gi|197927454 DEK oncogene isoform 2 [Homo sapiens]                     54   2e-07
gi|4503249 DEK oncogene isoform 1 [Homo sapiens]                       54   2e-07
gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]        54   2e-07
gi|91206454 hypothetical protein LOC257415 isoform 2 [Homo sapiens]    53   4e-07
gi|91206456 hypothetical protein LOC257415 isoform 1 [Homo sapiens]    53   4e-07
gi|55741709 RNA binding motif protein 25 [Homo sapiens]                53   5e-07
gi|52426743 cisplatin resistance-associated overexpressed protei...    53   5e-07
gi|19923485 cisplatin resistance-associated overexpressed protei...    53   5e-07
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ...    52   7e-07
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ...    52   7e-07
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]                       52   7e-07
gi|115298682 HBxAg transactivated protein 2 [Homo sapiens]             52   7e-07
gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain ...    52   9e-07
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa...    52   1e-06
gi|34878777 ring finger protein 20 [Homo sapiens]                      52   1e-06
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]     51   2e-06
gi|116089325 splicing factor, arginine/serine-rich 12 isoform a ...    51   2e-06
gi|21040255 splicing factor, arginine/serine-rich 12 isoform b [...    51   2e-06
gi|48255931 hepatoma-derived growth factor-related protein 2 iso...    51   2e-06
gi|14249158 hepatoma-derived growth factor-related protein 2 iso...    51   2e-06

>gi|224591430 Ly1 antibody reactive homolog [Homo sapiens]
          Length = 379

 Score =  773 bits (1995), Expect = 0.0
 Identities = 379/379 (100%), Positives = 379/379 (100%)

Query: 1   MVFFTCNACGESVKKIQVEKHVSVCRNCECLSCIDCGKDFWGDDYKNHVKCISEDQKYGG 60
           MVFFTCNACGESVKKIQVEKHVSVCRNCECLSCIDCGKDFWGDDYKNHVKCISEDQKYGG
Sbjct: 1   MVFFTCNACGESVKKIQVEKHVSVCRNCECLSCIDCGKDFWGDDYKNHVKCISEDQKYGG 60

Query: 61  KGYEGKTHKGDIKQQAWIQKISELIKRPNVSPKVRELLEQISAFDNVPRKKAKFQNWMKN 120
           KGYEGKTHKGDIKQQAWIQKISELIKRPNVSPKVRELLEQISAFDNVPRKKAKFQNWMKN
Sbjct: 61  KGYEGKTHKGDIKQQAWIQKISELIKRPNVSPKVRELLEQISAFDNVPRKKAKFQNWMKN 120

Query: 121 SLKVHNESILDQVWNIFSEASNSEPVNKEQDQRPLHPVANPHAEISTKVPASKVKDAVEQ 180
           SLKVHNESILDQVWNIFSEASNSEPVNKEQDQRPLHPVANPHAEISTKVPASKVKDAVEQ
Sbjct: 121 SLKVHNESILDQVWNIFSEASNSEPVNKEQDQRPLHPVANPHAEISTKVPASKVKDAVEQ 180

Query: 181 QGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVPE 240
           QGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVPE
Sbjct: 181 QGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVPE 240

Query: 241 ANGSAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPED 300
           ANGSAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPED
Sbjct: 241 ANGSAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPED 300

Query: 301 DEAPAKGKFNWKGTIKAILKQAPDNEITIKKLRKKVLAQYYTVTDEHHRSEEELLVIFNK 360
           DEAPAKGKFNWKGTIKAILKQAPDNEITIKKLRKKVLAQYYTVTDEHHRSEEELLVIFNK
Sbjct: 301 DEAPAKGKFNWKGTIKAILKQAPDNEITIKKLRKKVLAQYYTVTDEHHRSEEELLVIFNK 360

Query: 361 KISKNPTFKLLKDKVKLVK 379
           KISKNPTFKLLKDKVKLVK
Sbjct: 361 KISKNPTFKLLKDKVKLVK 379


>gi|8923398 Ly1 antibody reactive homolog [Homo sapiens]
          Length = 379

 Score =  773 bits (1995), Expect = 0.0
 Identities = 379/379 (100%), Positives = 379/379 (100%)

Query: 1   MVFFTCNACGESVKKIQVEKHVSVCRNCECLSCIDCGKDFWGDDYKNHVKCISEDQKYGG 60
           MVFFTCNACGESVKKIQVEKHVSVCRNCECLSCIDCGKDFWGDDYKNHVKCISEDQKYGG
Sbjct: 1   MVFFTCNACGESVKKIQVEKHVSVCRNCECLSCIDCGKDFWGDDYKNHVKCISEDQKYGG 60

Query: 61  KGYEGKTHKGDIKQQAWIQKISELIKRPNVSPKVRELLEQISAFDNVPRKKAKFQNWMKN 120
           KGYEGKTHKGDIKQQAWIQKISELIKRPNVSPKVRELLEQISAFDNVPRKKAKFQNWMKN
Sbjct: 61  KGYEGKTHKGDIKQQAWIQKISELIKRPNVSPKVRELLEQISAFDNVPRKKAKFQNWMKN 120

Query: 121 SLKVHNESILDQVWNIFSEASNSEPVNKEQDQRPLHPVANPHAEISTKVPASKVKDAVEQ 180
           SLKVHNESILDQVWNIFSEASNSEPVNKEQDQRPLHPVANPHAEISTKVPASKVKDAVEQ
Sbjct: 121 SLKVHNESILDQVWNIFSEASNSEPVNKEQDQRPLHPVANPHAEISTKVPASKVKDAVEQ 180

Query: 181 QGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVPE 240
           QGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVPE
Sbjct: 181 QGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVPE 240

Query: 241 ANGSAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPED 300
           ANGSAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPED
Sbjct: 241 ANGSAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPED 300

Query: 301 DEAPAKGKFNWKGTIKAILKQAPDNEITIKKLRKKVLAQYYTVTDEHHRSEEELLVIFNK 360
           DEAPAKGKFNWKGTIKAILKQAPDNEITIKKLRKKVLAQYYTVTDEHHRSEEELLVIFNK
Sbjct: 301 DEAPAKGKFNWKGTIKAILKQAPDNEITIKKLRKKVLAQYYTVTDEHHRSEEELLVIFNK 360

Query: 361 KISKNPTFKLLKDKVKLVK 379
           KISKNPTFKLLKDKVKLVK
Sbjct: 361 KISKNPTFKLLKDKVKLVK 379


>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 245

 Score = 67.0 bits (162), Expect = 3e-11
 Identities = 36/145 (24%), Positives = 78/145 (53%), Gaps = 4/145 (2%)

Query: 164 EISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKR 223
           EI T+    K +++  ++   ++ KR+R+ E+++KR+R KKE K E  +E    +K ++ 
Sbjct: 44  EIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKKRRRE 103

Query: 224 KKGQEADLEAGGEEVPEANGSAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETDSK 283
           K+ +E + +   ++  +       +  K+++RK+    EE +    +R+R+  E E + +
Sbjct: 104 KENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERK----ERERKKEEREKERE 159

Query: 284 KKKMKLPEHPEGGEPEDDEAPAKGK 308
           +K+ K  E  + GE E++    + K
Sbjct: 160 RKERKKRERKQVGEKEEERKEKERK 184



 Score = 56.6 bits (135), Expect = 4e-08
 Identities = 36/127 (28%), Positives = 67/127 (52%), Gaps = 15/127 (11%)

Query: 179 EQQGEVKKNKRERK-----------EERQKKRKREKKELKLENHQENSRNQKPKKRKKGQ 227
           E++GE KK +RERK           EE++K++K+EKKE +    +E    ++ ++RK+ +
Sbjct: 85  EKKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKE-RGRTSKEGKERERKEERKREE 143

Query: 228 EADLEAGGEEVPEANGSAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETDSKKKKM 287
             + E   EE  +      ++ +KK++RK    +EE R    +++R+  E     +KK+ 
Sbjct: 144 RKERERKKEEREKERE---RKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKER 200

Query: 288 KLPEHPE 294
           +  E  E
Sbjct: 201 ERKERRE 207



 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 31/115 (26%), Positives = 60/115 (52%), Gaps = 7/115 (6%)

Query: 173 KVKDAVEQQGEVKKNK-RERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADL 231
           K K+  E+    K+ K RERKEER+++ ++E++  K E  +E  R ++ K+ +K      
Sbjct: 116 KKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERKKRERK------ 169

Query: 232 EAGGEEVPEANGSAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETDSKKKK 286
           + G +E         +R K+++ RK+   E E +    ++K R  + E   +++K
Sbjct: 170 QVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKERKKKEERKKERQK 224



 Score = 48.9 bits (115), Expect = 7e-06
 Identities = 33/145 (22%), Positives = 68/145 (46%), Gaps = 5/145 (3%)

Query: 144 EPVNKEQDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKRE- 202
           E  NKE +++             T     + +   E++ E +K +  +KEER+K+R+R+ 
Sbjct: 103 EKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKERERKE 162

Query: 203 --KKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVPEANGSAGKRSKKKKQRKDSAS 260
             K+E K    +E  R +K +K +K +E + +   +E         +R K++K++++   
Sbjct: 163 RKKRERKQVGEKEEERKEKERKERKKRERNRKERKKE--RERKERRERKKERKKKEERKK 220

Query: 261 EEEARVGAGKRKRRHSEVETDSKKK 285
           E +       R++   + E   +KK
Sbjct: 221 ERQKDRQTNWREKERGKRERKERKK 245



 Score = 38.1 bits (87), Expect = 0.013
 Identities = 29/94 (30%), Positives = 46/94 (48%), Gaps = 5/94 (5%)

Query: 139 EASNSEPVNKEQDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKE--ERQ 196
           E    E   KE+ +R    V     E   K    + K   E+  + +K +RERKE  ER+
Sbjct: 152 EEREKERERKERKKRERKQVGEKEEERKEKERKERKKR--ERNRKERKKERERKERRERK 209

Query: 197 KKRKREKKELKLENHQENSRNQKPKKRKKGQEAD 230
           K+RK+ K+E K E  ++   N + K+R K +  +
Sbjct: 210 KERKK-KEERKKERQKDRQTNWREKERGKRERKE 242



 Score = 30.4 bits (67), Expect = 2.7
 Identities = 24/91 (26%), Positives = 38/91 (41%), Gaps = 6/91 (6%)

Query: 215 SRNQKPKKRKKGQEADLEAGGEEVPEANGSAGKRSKKKKQRKDSASEEEARVGAGKRKRR 274
           S   KP  +   Q    E   E      G   + S++KK+R++    +  R    KR+R 
Sbjct: 23  SHISKPCTQPGWQSEIREREREIETRKEGKKERESERKKERREREKRKREREKERKRERG 82

Query: 275 HSEVETDSK------KKKMKLPEHPEGGEPE 299
             E + + K      KK+ +  E+ EG E E
Sbjct: 83  KKEKKGERKKEERERKKRRREKENKEGEEKE 113


>gi|239508778 PREDICTED: hypothetical protein, partial [Homo
           sapiens]
          Length = 123

 Score = 63.5 bits (153), Expect = 3e-10
 Identities = 34/108 (31%), Positives = 66/108 (61%), Gaps = 7/108 (6%)

Query: 173 KVKDAVEQQGEVKKNKRERKEERQKKRKR---EKKELKLENHQENSRNQKPKKRKKGQEA 229
           + ++  E++G+ K+ ++E+++E++KK+K    EK++ K E  ++  R +K KK ++ +E 
Sbjct: 18  ETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKKRKRKRKKKKEEEEREE 77

Query: 230 DLEAGGEEVPEANGSAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSE 277
           + E   EE  E     G+R KKKK+R+    EEE +    K++RR ++
Sbjct: 78  EEEEEEEEKEEEEKEEGRRRKKKKKRRRKEEEEEKK----KKRRRKTK 121



 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 33/116 (28%), Positives = 56/116 (48%), Gaps = 12/116 (10%)

Query: 185 KKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVPEANGS 244
           KK K++  EE ++  + E++E K    +E  + ++ +K KK +  + E   E+  E    
Sbjct: 3   KKKKKKETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKKR 62

Query: 245 AGKRSKKK------------KQRKDSASEEEARVGAGKRKRRHSEVETDSKKKKMK 288
             KR KKK            ++ K+   +EE R    K+KRR  E E + KKK+ +
Sbjct: 63  KRKRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKKKKRRRKEEEEEKKKKRRR 118



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 34/110 (30%), Positives = 52/110 (47%), Gaps = 5/110 (4%)

Query: 185 KKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVPEANGS 244
           KK + E  EE ++  + E+KE K +  ++  R +K KK KK +E +     EE  +    
Sbjct: 6   KKKETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKK-KKTKETEKRKEKEEEEKKR-- 62

Query: 245 AGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETDSKKKKMKLPEHPE 294
             KR +KKK+ ++   EEE      K +    E     KKKK +  E  E
Sbjct: 63  --KRKRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKKKKRRRKEEEE 110



 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 29/115 (25%), Positives = 54/115 (46%)

Query: 221 KKRKKGQEADLEAGGEEVPEANGSAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVET 280
           KK+KK +E +     EE  E     GKR +K+K+++    +++      KRK +  E + 
Sbjct: 2   KKKKKKKETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKK 61

Query: 281 DSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITIKKLRKK 335
             +K+K K  E     E E++E   + +   +G  +   K+    E   +K +K+
Sbjct: 62  RKRKRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKKKKRRRKEEEEEKKKKR 116



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 23/90 (25%), Positives = 47/90 (52%), Gaps = 3/90 (3%)

Query: 144 EPVNKEQDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERK---EERQKKRK 200
           E   KE  ++          E   K   ++ +   E++ + +K KR++K   EER+++ +
Sbjct: 21  EEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKKRKRKRKKKKEEEEREEEEE 80

Query: 201 REKKELKLENHQENSRNQKPKKRKKGQEAD 230
            E++E + E  +E  R +K KKR++ +E +
Sbjct: 81  EEEEEKEEEEKEEGRRRKKKKKRRRKEEEE 110



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 23/90 (25%), Positives = 47/90 (52%), Gaps = 16/90 (17%)

Query: 167 TKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKG 226
           TK    + +   E++   +K K++++EE +++ + E++E K E  +E  R +K KK+++ 
Sbjct: 46  TKETEKRKEKEEEEKKRKRKRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKKKKRRR 105

Query: 227 QEADLEAGGEEVPEANGSAGKRSKKKKQRK 256
           +E + E                 KKK++RK
Sbjct: 106 KEEEEE----------------KKKKRRRK 119



 Score = 36.6 bits (83), Expect = 0.038
 Identities = 17/61 (27%), Positives = 34/61 (55%)

Query: 164 EISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKR 223
           E   K    K K+  E++ E ++ + E++EE +++ +R KK+ K    +E    +K ++R
Sbjct: 59  EKKRKRKRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKKKKRRRKEEEEEKKKKRRR 118

Query: 224 K 224
           K
Sbjct: 119 K 119



 Score = 30.4 bits (67), Expect = 2.7
 Identities = 18/86 (20%), Positives = 41/86 (47%), Gaps = 8/86 (9%)

Query: 148 KEQDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQK--------KR 199
           KE++++          E   +    K K   +++ E ++ + E +EE ++        +R
Sbjct: 38  KEKEKKKKTKETEKRKEKEEEEKKRKRKRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRR 97

Query: 200 KREKKELKLENHQENSRNQKPKKRKK 225
           K++KK  + E  +E  + ++ K +KK
Sbjct: 98  KKKKKRRRKEEEEEKKKKRRRKTKKK 123


>gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 275

 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 35/114 (30%), Positives = 63/114 (55%), Gaps = 9/114 (7%)

Query: 175 KDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAG 234
           K+  +++ E KK +R+++  R++K+K+E+KE + EN Q   R +K K+RKK +  + +  
Sbjct: 92  KERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRK-KRRKKKRRKERKRE 150

Query: 235 GEEVPEANGSAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETDSKKKKMK 288
            E         GKR +K+K+RK    E++      +RK+     E   +KK+ K
Sbjct: 151 KER--------GKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERK 196



 Score = 59.7 bits (143), Expect = 4e-09
 Identities = 37/148 (25%), Positives = 76/148 (51%), Gaps = 2/148 (1%)

Query: 167 TKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKG 226
           T+  + + K+  E++   ++ ++ERK ER KK K+++K+ +    +E  R ++ K+RK+ 
Sbjct: 30  TQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKER 89

Query: 227 QEADLEAGGEEVP--EANGSAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETDSKK 284
           +E +     +E    E      +  KKKK+RK+   E + R    ++KRR  +   + K+
Sbjct: 90  REKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKR 149

Query: 285 KKMKLPEHPEGGEPEDDEAPAKGKFNWK 312
           +K +     +  + + +E   K + N K
Sbjct: 150 EKERGKRERKRKKRKKEEREKKRERNRK 177



 Score = 58.9 bits (141), Expect = 7e-09
 Identities = 37/134 (27%), Positives = 67/134 (50%), Gaps = 13/134 (9%)

Query: 175 KDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAG 234
           K+   ++ E +K ++ER+E+ ++KRK+EKK  K E  Q   R +K KK +K +E +    
Sbjct: 73  KERERKRKEREKQRKERREKERRKRKKEKK--KRERKQRGRRERKKKKERKERERE---- 126

Query: 235 GEEVPEANGSAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETDSKKKKMKLPEHPE 294
                  N    +R +KK+++K    E +     GKR+R+  + + + ++KK +      
Sbjct: 127 -------NKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKER 179

Query: 295 GGEPEDDEAPAKGK 308
             E E  E   + K
Sbjct: 180 KKERERKERRERKK 193



 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 30/111 (27%), Positives = 63/111 (56%), Gaps = 9/111 (8%)

Query: 175 KDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAG 234
           K   E++   ++NK+ R+ +R+K+RK+++++ +    +   R +K KKRKK +       
Sbjct: 115 KKKKERKERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEER------ 168

Query: 235 GEEVPEANGSAGKRSKKKKQRKDSASE--EEARVGAGKRKRRHSEVETDSK 283
            E+  E N    K+ +++K+R++   E  +E R    ++K R ++ +TDS+
Sbjct: 169 -EKKRERNRKERKKERERKERRERKKERKKERRKKKERKKDRKTDRQTDSQ 218



 Score = 50.1 bits (118), Expect = 3e-06
 Identities = 31/115 (26%), Positives = 58/115 (50%), Gaps = 10/115 (8%)

Query: 184 VKKNKRERKEERQK-KRKREKKELKLENHQENSRNQKPKKRKKGQE---------ADLEA 233
           + K   +R+ ER+K +R+REK++ + E  ++  R +K KK++K +E          + E 
Sbjct: 25  ISKPCTQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREK 84

Query: 234 GGEEVPEANGSAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETDSKKKKMK 288
             +E  E      K+ KKK++RK     E  +    K + R ++   + K+KK +
Sbjct: 85  QRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRR 139



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 21/76 (27%), Positives = 42/76 (55%), Gaps = 6/76 (7%)

Query: 173 KVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLE 232
           K +   E++ + ++N++ERK+ER++K +RE+K+      +     +K K+RKK ++ D +
Sbjct: 161 KKRKKEEREKKRERNRKERKKERERKERRERKK------ERKKERRKKKERKKDRKTDRQ 214

Query: 233 AGGEEVPEANGSAGKR 248
              +       SA  R
Sbjct: 215 TDSQVFRPLRESAFNR 230


>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
           sapiens]
          Length = 600

 Score = 57.0 bits (136), Expect = 3e-08
 Identities = 32/136 (23%), Positives = 73/136 (53%), Gaps = 8/136 (5%)

Query: 175 KDAVEQQGEVKKNKRERKEERQKKRKREK-KELKLENHQENSRN-QKPKKRKKGQEADLE 232
           +D   ++   ++ +RER+ ER +KR+RE+ +E + E  +E  R+ +K ++RK+ ++ +++
Sbjct: 293 RDRETERKRERQRERERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMD 352

Query: 233 AGGEEVPEANGSAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETDSKKKKMKLPEH 292
                  E N   G+  +++ +R+     E  R  A +R+ R  + + D +K++ +  E 
Sbjct: 353 R------ERNRQTGREGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQTEK 406

Query: 293 PEGGEPEDDEAPAKGK 308
              G+ E ++   + K
Sbjct: 407 DRDGQRETEKQREREK 422



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 37/145 (25%), Positives = 64/145 (44%), Gaps = 13/145 (8%)

Query: 185 KKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQ---EADLEAGGEEVPEA 241
           ++ +RER+ +RQ  R+RE++E   +  ++  R ++ +K + GQ   E   E   +   E 
Sbjct: 369 RERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESER 428

Query: 242 NGSAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETDSKKKKMKL----PEHPEGG- 296
               G+  +K+K R+     +  R    +RKR    V    +  +  +    P  P  G 
Sbjct: 429 GRERGREREKQKGRERDRERQTDRQAGRQRKRSTLYVNPPPRTARSGVVQSDPNRPTRGI 488

Query: 297 ----EPEDDEAPAKGKFNWKGTIKA 317
                PED +A A  +F W    KA
Sbjct: 489 RWKSSPEDPKA-ASTRFPWGRPAKA 512



 Score = 45.4 bits (106), Expect = 8e-05
 Identities = 25/111 (22%), Positives = 54/111 (48%), Gaps = 9/111 (8%)

Query: 185 KKNKRERKEERQKKRKREKKELKLENHQENSRNQK---------PKKRKKGQEADLEAGG 235
           ++ ++ R+E R+++R+REK+    + H E  R ++          +KR+  +E D +   
Sbjct: 179 REREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKT 238

Query: 236 EEVPEANGSAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETDSKKKK 286
           E   E      + S+++ +R      E  R     R+++  E +TD K+++
Sbjct: 239 EREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQR 289



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 26/124 (20%), Positives = 60/124 (48%), Gaps = 12/124 (9%)

Query: 175 KDAVEQQGEVKKNKRERKEERQKKRKREK-------KELKLENHQENSRNQKPKKRKKGQ 227
           K+   Q    +  +RE++  RQK+R+RE        ++ + +  +E  R +  +K ++ Q
Sbjct: 103 KERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQ 162

Query: 228 -----EADLEAGGEEVPEANGSAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETDS 282
                +   E   ++  E   +  +R ++++QR+     E+     G+ + R  E ET++
Sbjct: 163 TDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETET 222

Query: 283 KKKK 286
           ++K+
Sbjct: 223 ERKR 226



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 25/115 (21%), Positives = 62/115 (53%), Gaps = 4/115 (3%)

Query: 185 KKNKRERKEERQKKRKREKKELKLENHQ--ENSRNQKPKKRKKGQEADLEAGGEEVPEAN 242
           ++ +R+R++ER++KRKR+ +  +  N Q     R Q  ++R++ +E D ++  E   E  
Sbjct: 331 RETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSARER--EER 388

Query: 243 GSAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGE 297
                R ++K++ + +  + + +    K++ R  + E++  +++ +  E  +G E
Sbjct: 389 ERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESERGRERGREREKQKGRE 443



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 30/115 (26%), Positives = 61/115 (53%), Gaps = 6/115 (5%)

Query: 179 EQQGEVKKNKRERKEERQKKRKREKK-ELKLENHQENSRNQKPKKRKKGQEADLEAGGEE 237
           E+Q E +    +R  ER ++R+RE++ E + E  ++  R ++ ++RK  +E + +A  E 
Sbjct: 192 ERQREKENKTEDRHSERGRERERERETETETERKRQTDR-ERDRQRKTEREREKQAERER 250

Query: 238 VPEANGSAGKRSKKKKQR---KDSASEEEARVGAGKRKRR-HSEVETDSKKKKMK 288
             E      K  ++++ R   +D   +E  R    KR+RR   + ET+ K+++ +
Sbjct: 251 ASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQR 305



 Score = 43.5 bits (101), Expect = 3e-04
 Identities = 30/160 (18%), Positives = 75/160 (46%), Gaps = 5/160 (3%)

Query: 147 NKEQDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKK--RKREKK 204
           N+++++           E   K    + KD   ++   ++ +R+R++ER+++  R+R+++
Sbjct: 57  NRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDRERDRQ 116

Query: 205 ELKLENHQENSRNQKPKKRKKG--QEADLEAGGEEVPEANGSAGKRSKKKKQRKDSASEE 262
             K  N Q+    +  ++ ++G  ++ D +   E   +A     +++ +++QR+   + +
Sbjct: 117 REKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQ 176

Query: 263 EARVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDE 302
           + R     R+ R  E E   +K+      H E G   + E
Sbjct: 177 KEREREKNRQERR-ERERQREKENKTEDRHSERGRERERE 215



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 27/126 (21%), Positives = 64/126 (50%), Gaps = 14/126 (11%)

Query: 175 KDAVEQQGEVKKNKRERKEER--QKKRKREK---------KELKLENHQENSRNQKPKKR 223
           +DA +++      +R+R+ ER  QK+R+REK         ++ + EN  E+  +++ ++R
Sbjct: 153 RDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRER 212

Query: 224 KKGQEADLEAGGEEVPEANGSAGK---RSKKKKQRKDSASEEEARVGAGKRKRRHSEVET 280
           ++ +E + E   +   +      +   R ++K+  ++ ASE E      + + R  + + 
Sbjct: 213 ERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDR 272

Query: 281 DSKKKK 286
           D ++K+
Sbjct: 273 DRRQKE 278



 Score = 40.8 bits (94), Expect = 0.002
 Identities = 29/113 (25%), Positives = 54/113 (47%), Gaps = 5/113 (4%)

Query: 179 EQQGEVKKNKR---ERKEERQKKRKREKKELKLENHQE-NSRNQKPKKRKKGQEADLEAG 234
           E+Q + +K +    +R+ +RQ +R R+K+  + +N QE   R ++ +K  K ++   E G
Sbjct: 150 ERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERG 209

Query: 235 GEEVPEANGSAGKRSKKKKQR-KDSASEEEARVGAGKRKRRHSEVETDSKKKK 286
            E   E         K++  R +D   + E        + R SE ET+  K++
Sbjct: 210 RERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKER 262



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 27/154 (17%), Positives = 70/154 (45%), Gaps = 3/154 (1%)

Query: 139 EASNSEPVNKEQD-QRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQK 197
           E       ++E+D QR          E  T+    + +D        ++ +R+ ++ER++
Sbjct: 102 EKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERER 161

Query: 198 KRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVPEANGSAGKRSKKKKQRKD 257
           +  RE++     N Q+    +K ++ ++ +E   E   E   E   S   R +++++  +
Sbjct: 162 QTDRERQRQTERNRQKEREREKNRQERRERERQREK--ENKTEDRHSERGRERERERETE 219

Query: 258 SASEEEARVGAGKRKRRHSEVETDSKKKKMKLPE 291
           + +E + +    + ++R +E E + + ++ +  E
Sbjct: 220 TETERKRQTDRERDRQRKTEREREKQAERERASE 253



 Score = 39.3 bits (90), Expect = 0.006
 Identities = 30/163 (18%), Positives = 74/163 (45%), Gaps = 18/163 (11%)

Query: 139 EASNSEPVNKEQDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKK 198
           E +  E   +E+ +   +   + H+E   +    + ++   +    ++  RER  +R+ +
Sbjct: 182 EKNRQERRERERQREKENKTEDRHSERGRE--RERERETETETERKRQTDRERDRQRKTE 239

Query: 199 RKREK---------------KELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVPEANG 243
           R+REK               KE + E  ++  R+++ K+R++  +   +   E   E   
Sbjct: 240 REREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETER 299

Query: 244 SAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETDSKKKK 286
              ++ +++++R+ +   E  R    +R+R+  E E D +K++
Sbjct: 300 KRERQRERERERERNRKRERERERERERERQR-ETERDREKER 341



 Score = 37.4 bits (85), Expect = 0.022
 Identities = 27/135 (20%), Positives = 59/135 (43%), Gaps = 12/135 (8%)

Query: 164 EISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQ----- 218
           + S + P S+        G+  K+      ER ++++RE++  K +  +E  R +     
Sbjct: 25  DFSRRRPGSQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRRE 84

Query: 219 --KPKKRKKGQEADLEAGGEEVPEANGSAGKRSKKKKQRKDSASEEEARVGAGKRKR--- 273
             + +KR + +E   +   E   + +    ++ +K++ R+     E  R G   R R   
Sbjct: 85  KDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTD 144

Query: 274 --RHSEVETDSKKKK 286
             R  E + D++K++
Sbjct: 145 GQRERERQRDAEKER 159



 Score = 36.2 bits (82), Expect = 0.050
 Identities = 32/198 (16%), Positives = 81/198 (40%), Gaps = 27/198 (13%)

Query: 143 SEPVNKEQDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKRE 202
           +E   + Q +R      N   E   +    + +    ++   K+ +R+RK + +  R+R 
Sbjct: 297 TERKRERQRERERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRERN 356

Query: 203 K-----------KELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVPEANGSAGKRSKK 251
           +           +E + E  ++    ++ ++R++ ++ D +   E   E +    + ++K
Sbjct: 357 RQTGREGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEK 416

Query: 252 KKQR---------KDSASEEEARVGAGKRKRRHSEVETDSKKKKMKLPEHP------EGG 296
           +++R         ++   E E + G  + + R ++ +   ++K+  L  +P       G 
Sbjct: 417 QREREKDRESERGRERGREREKQKGRERDRERQTDRQAGRQRKRSTLYVNPPPRTARSGV 476

Query: 297 EPEDDEAPAKGKFNWKGT 314
              D   P +G   WK +
Sbjct: 477 VQSDPNRPTRG-IRWKSS 493



 Score = 35.4 bits (80), Expect = 0.085
 Identities = 20/116 (17%), Positives = 53/116 (45%), Gaps = 4/116 (3%)

Query: 186 KNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVPEANGSA 245
           + KR+   ER ++RK E++  K    +  S  +  + +++ +E D +   +   +     
Sbjct: 223 ERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQ 282

Query: 246 GKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDD 301
             R ++++  +D  +E +      +++ R  E E + K+++ +  E     + E +
Sbjct: 283 TDRKRQRRTERDRETERKRE----RQRERERERERNRKRERERERERERERQRETE 334


>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
           sapiens]
          Length = 1152

 Score = 56.6 bits (135), Expect = 4e-08
 Identities = 33/128 (25%), Positives = 67/128 (52%), Gaps = 5/128 (3%)

Query: 181 QGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVPE 240
           +GE ++  RE +EE++ + K E +  ++E  +E    ++ K+ + G+E   E G EE  +
Sbjct: 737 EGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKE---EKGEEEGDQ 793

Query: 241 ANGSAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPED 300
             G   +   + +++++    E   V  GK +R   E E + ++++ +  E  E GE E+
Sbjct: 794 GEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEE--EEGEGEE 851

Query: 301 DEAPAKGK 308
           +E   KG+
Sbjct: 852 EEGEGKGE 859



 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 42/143 (29%), Positives = 72/143 (50%), Gaps = 16/143 (11%)

Query: 173 KVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENH-----QENSRNQKPKKRKKGQ 227
           K +D  EQ+      ++ER++  QK+R +E +E   E H     +E  R ++ +K  +G+
Sbjct: 703 KKRDGEEQE------QKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGK 756

Query: 228 EADLEAGGEEVP-EANGSAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETDSKKKK 286
           E   E  GEEV  E     G+R K+++  K+   EEE   G G+ +      E   +  +
Sbjct: 757 E---EGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGE 813

Query: 287 MKLPEHPEG-GEPEDDEAPAKGK 308
           ++  E  EG GE E++E   +G+
Sbjct: 814 VEGGEVEEGKGEREEEEEEGEGE 836



 Score = 52.0 bits (123), Expect = 9e-07
 Identities = 34/142 (23%), Positives = 71/142 (50%), Gaps = 3/142 (2%)

Query: 175 KDAVEQQGEVKKNKRERKEERQ-KKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEA 233
           +D   ++GE  K + E +   + +K   EK+E K  + +E  + ++ +  +K +  ++E 
Sbjct: 670 QDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEE 729

Query: 234 GGEE-VPEANGSAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETDSKK-KKMKLPE 291
           GGEE   E     G R +++++  +   E E     G+R++   E + + +  K+ K  E
Sbjct: 730 GGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEE 789

Query: 292 HPEGGEPEDDEAPAKGKFNWKG 313
             + GE E++E   +G+   +G
Sbjct: 790 EGDQGEGEEEETEGRGEEKEEG 811



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 35/130 (26%), Positives = 62/130 (47%), Gaps = 9/130 (6%)

Query: 182 GEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVPEA 241
           GEV++ K ER+EE ++    E++    E  +E    ++ +   KG+E   E  GEE  E 
Sbjct: 817 GEVEEGKGEREEEEEEGEGEEEEG---EGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEE 873

Query: 242 NGSAGKRSK---KKKQRKDSASEEEARVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEP 298
               G+  +   + ++  +   EEE   G G+ +    E E + ++ + K  E  E GE 
Sbjct: 874 GEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEE---GEGEGEEEEGEGKGEEEGEEGEG 930

Query: 299 EDDEAPAKGK 308
           E +E   +G+
Sbjct: 931 EGEEEEGEGE 940



 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 36/154 (23%), Positives = 69/154 (44%), Gaps = 20/154 (12%)

Query: 179 EQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADL--EAGGE 236
           E +GE  + +RE++E  +KK +R  KE K E   +    ++ +   +G+E +   E  G 
Sbjct: 758 EGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGG 817

Query: 237 EVPEANGSAGKRSKK-----------------KKQRKDSASEEEARVGAGKRKRRHSEVE 279
           EV E  G   +  ++                 +++  +   EEE   G G+ +    E E
Sbjct: 818 EVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGE 877

Query: 280 TDSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKG 313
            + ++ + +  E  E GE E++E   +G+   +G
Sbjct: 878 GEEEEGEGEGEEEGE-GEGEEEEGEGEGEEEGEG 910



 Score = 45.8 bits (107), Expect = 6e-05
 Identities = 36/171 (21%), Positives = 77/171 (45%), Gaps = 5/171 (2%)

Query: 148 KEQDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELK 207
           KE++Q         H E   +    + ++  E +G+ +    E + ER+K+    KKE +
Sbjct: 721 KERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEER 780

Query: 208 L----ENHQENSRNQKPKKRKKGQEADLEAGGE-EVPEANGSAGKRSKKKKQRKDSASEE 262
                +  +E  + +  ++  +G+  + E GGE E  E     G+R +++++ +    E 
Sbjct: 781 AGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEG 840

Query: 263 EARVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKG 313
           E     G+ +    E + + + ++ +  E  E GE E +E   +G+   +G
Sbjct: 841 EGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEG 891



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 36/140 (25%), Positives = 61/140 (43%), Gaps = 16/140 (11%)

Query: 176 DAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGG 235
           D  E + E  + + E KEE  +    E +E K E  +E    +  ++  +G+E + E G 
Sbjct: 792 DQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGE-GE 850

Query: 236 EEVPEANGSAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETDSKKKKMKLPEHPEG 295
           EE  E  G        +++ ++   EEE   G G+ +    E E + + +     E  EG
Sbjct: 851 EEEGEGKG--------EEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEG 902

Query: 296 -------GEPEDDEAPAKGK 308
                  GE E++E   KG+
Sbjct: 903 EGEEEGEGEGEEEEGEGKGE 922



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 33/140 (23%), Positives = 63/140 (45%), Gaps = 10/140 (7%)

Query: 175 KDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAG 234
           ++  E +GE K+   E +    ++ K E++E + E   E    +  ++  +G+E + E  
Sbjct: 798 EEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGK 857

Query: 235 GEEVPEANGSAGKRSKKKKQRKDSASEEEA-----RVGAGKRKRRHSEVETDSKKKKMKL 289
           GEE     G  G+  ++ ++ +    EEE        G G+ +    E E + + +    
Sbjct: 858 GEE----EGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGE 913

Query: 290 PEHPEG-GEPEDDEAPAKGK 308
            E  EG GE E +E   +G+
Sbjct: 914 EEEGEGKGEEEGEEGEGEGE 933



 Score = 39.3 bits (90), Expect = 0.006
 Identities = 29/138 (21%), Positives = 61/138 (44%), Gaps = 3/138 (2%)

Query: 179 EQQGEVKKNKRERKEERQK---KRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGG 235
           E++GE ++ + E +EE  +   + + E+ E + E  +     ++ +   +G+E     G 
Sbjct: 837 EEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGE 896

Query: 236 EEVPEANGSAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETDSKKKKMKLPEHPEG 295
           EE  E  G      + +++  +   EEE   G G+ +    E E +  + + +  E    
Sbjct: 897 EEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWE 956

Query: 296 GEPEDDEAPAKGKFNWKG 313
           GE E+ E   + +   +G
Sbjct: 957 GEEEEGEGEGEEEGEGEG 974



 Score = 38.1 bits (87), Expect = 0.013
 Identities = 28/131 (21%), Positives = 62/131 (47%), Gaps = 5/131 (3%)

Query: 179  EQQGEVKKNKRERKEERQK-KRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEE 237
            E +GE ++ + + +EE ++ + + E++E + E        ++ +   +G+E + E  GEE
Sbjct: 909  EGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEE 968

Query: 238  VPEANGSAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGE 297
              E  G  G+   ++++ +    EEE      +      E E + ++++    E    GE
Sbjct: 969  EGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEE----EGEVEGE 1024

Query: 298  PEDDEAPAKGK 308
             E +E   +G+
Sbjct: 1025 VEGEEGEGEGE 1035



 Score = 37.4 bits (85), Expect = 0.022
 Identities = 34/166 (20%), Positives = 69/166 (41%), Gaps = 13/166 (7%)

Query: 179  EQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEV 238
            E++GE +  +    EE  +    E++E ++E   E    +   + ++G+    E G E  
Sbjct: 992  EEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGE----EEGEERE 1047

Query: 239  PEANGSAGKRSKKKKQRKD----SASEEEARVGAGKRKRRHSEVETDSKKKKMKLPEHPE 294
             E  G   +R++++++ ++       EEE     G+  ++ S+++   K  K K  +   
Sbjct: 1048 KEGEGEENRRNREEEEEEEGKYQETGEEENERQDGEEYKKVSKIKGSVKYGKHKTYQKKS 1107

Query: 295  GGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITIKKLRKKVLAQY 340
                + +    + K   +   K +LK  P      KK    VL  Y
Sbjct: 1108 VTNTQGNGKEQRSKMPVQS--KRLLKNGPSGS---KKFWNNVLPHY 1148



 Score = 37.0 bits (84), Expect = 0.029
 Identities = 30/136 (22%), Positives = 63/136 (46%), Gaps = 6/136 (4%)

Query: 175 KDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRK-KGQEADLEA 233
           ++  E +GE +  + E + E ++     ++E + E  +E    +  ++ + +G+E + E 
Sbjct: 860 EEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEG 919

Query: 234 GGEEVPEANGSAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETDSKKKKMKLPEHP 293
            GEE  E     G+  + + + +D   E E   G  + +    E E + + +     E  
Sbjct: 920 KGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGE----GEGE 975

Query: 294 EG-GEPEDDEAPAKGK 308
           EG GE E++E   +G+
Sbjct: 976 EGEGEGEEEEGEGEGE 991



 Score = 36.6 bits (83), Expect = 0.038
 Identities = 23/110 (20%), Positives = 50/110 (45%)

Query: 179  EQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEV 238
            E++GE +  + E +EE +++ + E++       +E    +   + ++G+    E  GEE 
Sbjct: 983  EEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEE 1042

Query: 239  PEANGSAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETDSKKKKMK 288
             E     G+  + ++ R++   EE      G+ +    + E   K  K+K
Sbjct: 1043 GEEREKEGEGEENRRNREEEEEEEGKYQETGEEENERQDGEEYKKVSKIK 1092



 Score = 35.8 bits (81), Expect = 0.065
 Identities = 26/105 (24%), Positives = 50/105 (47%), Gaps = 3/105 (2%)

Query: 209 ENHQENSRNQKPKKRKKGQEADLEAGGEEVPEANGSAGKRSKKKKQRKDSASEEEARVGA 268
           E     + + + ++R+KG E D   G  E P   G      K++ +++D   +E+     
Sbjct: 660 EEGSSGAEHWQDEEREKG-EKDKGRGEMERP-GEGEKELAEKEEWKKRDGEEQEQKEREQ 717

Query: 269 GKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKG 313
           G +K R+ E+E   +++  +  E  EG   E++E   +GK   +G
Sbjct: 718 GHQKERNQEMEEGGEEEHGE-GEEEEGDREEEEEKEGEGKEEGEG 761



 Score = 35.8 bits (81), Expect = 0.065
 Identities = 30/127 (23%), Positives = 58/127 (45%), Gaps = 10/127 (7%)

Query: 173  KVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLE 232
            +V+  VE +    + + E  EE  ++R++E +  +   ++E    ++ K ++ G+E +  
Sbjct: 1020 EVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGEEENER 1079

Query: 233  AGGEEVPEANGSAG--KRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETDSKKKKMKLP 290
              GEE  + +   G  K  K K  +K S +  +   G GK +R    V++     K  L 
Sbjct: 1080 QDGEEYKKVSKIKGSVKYGKHKTYQKKSVTNTQ---GNGKEQRSKMPVQS-----KRLLK 1131

Query: 291  EHPEGGE 297
              P G +
Sbjct: 1132 NGPSGSK 1138



 Score = 34.7 bits (78), Expect = 0.15
 Identities = 34/153 (22%), Positives = 64/153 (41%), Gaps = 18/153 (11%)

Query: 168 KVPASKVKDAVEQQGEVKKNKRERKEERQKKR--KREKKELKLENHQENSRNQKPKKRKK 225
           ++P  K      +   +++ + E  EE  K    ++EK E+  ++  + +   + K +  
Sbjct: 585 EIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKAKSV 644

Query: 226 GQEADLEAGGEEVPEANGSAGKR----SKKKKQRKDSASEEEARVGAGKR--------KR 273
           G+  D   G  +     GS+G       +++K  KD    E  R G G++        K+
Sbjct: 645 GEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKK 704

Query: 274 RHSEVETDSKK----KKMKLPEHPEGGEPEDDE 302
           R  E +   ++    +K +  E  EGGE E  E
Sbjct: 705 RDGEEQEQKEREQGHQKERNQEMEEGGEEEHGE 737



 Score = 33.9 bits (76), Expect = 0.25
 Identities = 32/138 (23%), Positives = 58/138 (42%), Gaps = 19/138 (13%)

Query: 179  EQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEV 238
            E +GE ++ + E +EE  ++   E+ E + E   E    ++ +   + +  + E  GEE 
Sbjct: 978  EGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEE- 1036

Query: 239  PEANGSAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEP 298
                           +  +   EE  + G G+  RR+ E E + + K  +  E  E  E 
Sbjct: 1037 ---------------EEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGE--EENER 1079

Query: 299  EDDEAPAKGKFNWKGTIK 316
            +D E   K     KG++K
Sbjct: 1080 QDGEEYKKVS-KIKGSVK 1096



 Score = 32.7 bits (73), Expect = 0.55
 Identities = 35/151 (23%), Positives = 68/151 (45%), Gaps = 16/151 (10%)

Query: 179  EQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKP---KKRKKGQEADLEAGG 235
            E +GE ++ + E +EE + + + E+ E + E   E    ++    K  ++G+E + E G 
Sbjct: 875  EGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGE-GE 933

Query: 236  EEVPEANGSAGKRSKKKKQRKDSASEEEAR-------VGAGKRKRRHSEVETDSKKKKMK 288
            EE  E  G  G+   ++++ +    EEE          G G+      E E    + + +
Sbjct: 934  EEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEE 993

Query: 289  LPEHPEGGEPE---DDEAPAKGKFNWKGTIK 316
              E  E GE E   ++E   +G+   +G ++
Sbjct: 994  --EGEEEGEEEGEGEEEGEGEGEEEEEGEVE 1022


>gi|7661950 SH2 domain binding protein 1 [Homo sapiens]
          Length = 1173

 Score = 56.6 bits (135), Expect = 4e-08
 Identities = 53/195 (27%), Positives = 88/195 (45%), Gaps = 29/195 (14%)

Query: 179  EQQGEVKKNKRERKEERQKKRKREKKELKLEN---HQENSRN----------QKPKKRKK 225
            EQ+ E+ + K  +++E ++ R++E+++  LE    + E ++N           K KKR  
Sbjct: 846  EQEKELLRQKLLKEQEEKRLREKEEQKKLLEQRAQYVEKTKNILMFTGETEATKEKKRGG 905

Query: 226  GQEADLEAGGEEVPEANGSAGKR---SKKKKQRKDSASEEEARVGAGKRKRRHSEVETDS 282
            G     + GGE     N         SKKKK+RK S SE+E             E E   
Sbjct: 906  GGGRRSKKGGEFDEFVNDDTDDDLPISKKKKRRKGSGSEQEG------------EDEEGG 953

Query: 283  KKKKMKLPEHPEGGEPEDDEAPAKG-KFNWKGTIKAILKQAPDNEITIKKLRKKVLAQYY 341
            ++KK K   HP+G E  DD+    G K   +   KA  K+AP  E     ++ K+ ++  
Sbjct: 954  ERKKKKRRRHPKGEEGSDDDETENGPKPKKRRPPKAEKKKAPKPERLPPSMKGKIKSKAI 1013

Query: 342  TVTDEHHRSEEELLV 356
              + +    E++L +
Sbjct: 1014 ISSSDDSSDEDKLKI 1028



 Score = 46.6 bits (109), Expect = 4e-05
 Identities = 38/156 (24%), Positives = 70/156 (44%), Gaps = 15/156 (9%)

Query: 148  KEQDQRPLHPVANPHAEISTKVP-ASKVKDAVEQQGEVKKNKRERK---EERQKKRKREK 203
            KEQ+++ L         +  +     K K+ +   GE +  K +++     R+ K+  E 
Sbjct: 858  KEQEEKRLREKEEQKKLLEQRAQYVEKTKNILMFTGETEATKEKKRGGGGGRRSKKGGEF 917

Query: 204  KELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVPEANGSAGKRSKKKKQR----KDSA 259
             E   ++  ++    K KKR+KG  ++ E   EE        G+R KKK++R    ++ +
Sbjct: 918  DEFVNDDTDDDLPISKKKKRRKGSGSEQEGEDEE-------GGERKKKKRRRHPKGEEGS 970

Query: 260  SEEEARVGAGKRKRRHSEVETDSKKKKMKLPEHPEG 295
             ++E   G   +KRR  + E     K  +LP   +G
Sbjct: 971  DDDETENGPKPKKRRPPKAEKKKAPKPERLPPSMKG 1006



 Score = 40.0 bits (92), Expect = 0.003
 Identities = 47/186 (25%), Positives = 73/186 (39%), Gaps = 49/186 (26%)

Query: 169  VPASKVKDAVEQQGEVKKNKRERKEERQKK-RKREKKELKLENHQENSRNQKPKKRK--- 224
            +P SK K   +  G  ++ + E   ER+KK R+R  K  +  +  E     KPKKR+   
Sbjct: 929  LPISKKKKRRKGSGSEQEGEDEEGGERKKKKRRRHPKGEEGSDDDETENGPKPKKRRPPK 988

Query: 225  ----------------KGQ---------------EADLEAGGEEVPEANGSAGKRSKKKK 253
                            KG+               E  L+   E  P  N ++   S + +
Sbjct: 989  AEKKKAPKPERLPPSMKGKIKSKAIISSSDDSSDEDKLKIADEGHPR-NSNSNSDSDEDE 1047

Query: 254  QRKDSASEEE----------ARVGAGKRKRRH-SEVETDSKKKKMKLPEHPEGGEPEDDE 302
            QRK  AS E           +  G+ +R RR  S+ ++DS +   K    P G E  D+E
Sbjct: 1048 QRKKCASSESDSDENQNKSGSEAGSPRRPRRQRSDQDSDSDQPSRK--RRPSGSEQSDNE 1105

Query: 303  APAKGK 308
            +   G+
Sbjct: 1106 SVQSGR 1111



 Score = 29.3 bits (64), Expect = 6.1
 Identities = 28/139 (20%), Positives = 52/139 (37%), Gaps = 15/139 (10%)

Query: 173  KVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLE 232
            K+K A E       +  +  E+ Q+K+    +    EN  ++       +R + Q +D +
Sbjct: 1025 KLKIADEGHPRNSNSNSDSDEDEQRKKCASSESDSDENQNKSGSEAGSPRRPRRQRSDQD 1084

Query: 233  AGGEEVPEANGSAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEV-ETDSKKKKMKLPE 291
            +  ++             +K++   S   +   V +G   R HS V E DS+        
Sbjct: 1085 SDSDQ-----------PSRKRRPSGSEQSDNESVQSG---RSHSGVSENDSRPASPSAES 1130

Query: 292  HPEGGEPEDDEAPAKGKFN 310
              E     D+E   +G  N
Sbjct: 1131 DHESERGSDNEGSGQGSGN 1149


>gi|153945728 microtubule-associated protein 1B [Homo sapiens]
          Length = 2468

 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 44/172 (25%), Positives = 82/172 (47%), Gaps = 14/172 (8%)

Query: 163 AEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKEL-KLENHQENSRNQKPK 221
           AE++ K  A+ VK    ++  VKK  + + E++++++++ KKE+ K E+     + +KPK
Sbjct: 618 AEVAEK-QATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPK 676

Query: 222 KRKKGQEADLEAGGEEVPEANGSAGK------------RSKKKKQRKDSASEEEARVGAG 269
           K +  +E   E   EE  E      K            + +KK+ +K+    ++      
Sbjct: 677 KEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLP 736

Query: 270 KRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQ 321
           K  ++ S   +++KK     P+ P+  E    ++ A GK   KG IK I K+
Sbjct: 737 KDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKGKIKVIKKE 788



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 51/204 (25%), Positives = 81/204 (39%), Gaps = 24/204 (11%)

Query: 83  ELIKRPNVSPKVRELLEQISAFDNVPRKKAKFQNWMKNSLKVHNESILDQVWNIFSEASN 142
           E+  +   SP   E+ E+  A D  P  KA  +  +K   KV  E   ++      E + 
Sbjct: 606 EVPSKEEPSPVKAEVAEK-QATDVKP--KAAKEKTVKKETKVKPEDKKEEKEKPKKEVAK 662

Query: 143 SE---PVNKEQDQRP------------LHPVANPHAEISTKVPASKVKDAV--EQQGEVK 185
            E   P+ KE+  +                   P  E+  + P  +VK  V  E++ EVK
Sbjct: 663 KEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVK 722

Query: 186 KNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVPEANGSA 245
           K ++E K+E +K  K  KK     +  +     KPK  KK +    ++     P+  G  
Sbjct: 723 KEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKG-- 780

Query: 246 GKRSKKKKQRKDSASEEEARVGAG 269
             + K  K+   +A    A VG G
Sbjct: 781 --KIKVIKKEGKAAEAVAAAVGTG 802



 Score = 32.3 bits (72), Expect = 0.72
 Identities = 39/167 (23%), Positives = 68/167 (40%), Gaps = 13/167 (7%)

Query: 204 KELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVPEANGSAGKRSKKKKQRKDSASEEE 263
           K+ KL+   ++  + KP  +    ++  +   EE PE        +K     K    E +
Sbjct: 531 KQTKLKQRADSRESLKPAAKPLPSKSVRKESKEETPEV-------TKVNHVEKPPKVESK 583

Query: 264 ARVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPA---KGKFNWKGTIKAILK 320
            +V   K K   +E +    +K++   E P   + E  E  A   K K   + T+K   K
Sbjct: 584 EKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETK 643

Query: 321 QAPDNEITIKKLRKKVLAQYYTVT---DEHHRSEEELLVIFNKKISK 364
             P+++   K+  KK +A+    T    E    +EE+     K+I K
Sbjct: 644 VKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKK 690


>gi|27734775 hypothetical protein LOC286499 [Homo sapiens]
          Length = 248

 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 47/217 (21%), Positives = 99/217 (45%), Gaps = 17/217 (7%)

Query: 81  ISELIKRPNVSPKVRELLEQISAFDNVPRKKAKFQNWMKNSLKVHNESILDQVWNIFSEA 140
           I + + RP   P   E+ +Q+       +  A+F+  M  + K   E   +++ +  +E+
Sbjct: 30  IQDYLNRPR--PTWEEVKKQLENKKTGSKALAEFEEKMNENWKKELEKSREKLLS-GNES 86

Query: 141 SNSEPVNKEQDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERK-------- 192
           S+ +   K++ ++     ++  +   +   +S  +D  ++QG+ +K K+ R         
Sbjct: 87  SSKKRERKKKRKKKSCRSSSSSSSSDSSSSSSDSEDEEKKQGKRRKKKKNRSYKSSQSST 146

Query: 193 ---EERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVPEANGSAGKRS 249
              E   K+  ++KK+ K E  +E       KKRKK    D     E   E++     ++
Sbjct: 147 HESESESKESVKKKKKSKDETEKEKDVRSLSKKRKKSYPDDKPLSSESSSESDYEEDVQA 206

Query: 250 KKKKQRKDSASEEEARVGAGKRKRRHSEVETDSKKKK 286
           KKK++ ++    E+A+    K+K++  +  +  KKKK
Sbjct: 207 KKKRRCEE---REQAKEKVKKKKKKQHKKHSKKKKKK 240



 Score = 48.1 bits (113), Expect = 1e-05
 Identities = 37/168 (22%), Positives = 77/168 (45%), Gaps = 17/168 (10%)

Query: 190 ERKEERQKKRKREKKELKLENHQENSRNQKPKKRKK---------GQEADLEAGGEEVPE 240
           E+  E  KK   + +E  L  ++ +S+ ++ KK++K            +D  +   +  +
Sbjct: 63  EKMNENWKKELEKSREKLLSGNESSSKKRERKKKRKKKSCRSSSSSSSSDSSSSSSDSED 122

Query: 241 ANGSAGKRSKKKKQR-----KDSASEEEARVGAGKRKRRHSEVETDSKKKKMKLPEHPEG 295
                GKR KKKK R     + S  E E+      +K++ S+ ET+ +K    L +  + 
Sbjct: 123 EEKKQGKRRKKKKNRSYKSSQSSTHESESESKESVKKKKKSKDETEKEKDVRSLSKKRKK 182

Query: 296 GEPEDD--EAPAKGKFNWKGTIKAILK-QAPDNEITIKKLRKKVLAQY 340
             P+D    + +  + +++  ++A  K +  + E   +K++KK   Q+
Sbjct: 183 SYPDDKPLSSESSSESDYEEDVQAKKKRRCEEREQAKEKVKKKKKKQH 230



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 33/132 (25%), Positives = 65/132 (49%), Gaps = 7/132 (5%)

Query: 138 SEASNSEPVNKEQDQRPLHPVANPH--AEISTKVPASKVKDAVEQQGEVKKNKRERKEER 195
           S +S+SE   K+Q +R        +  ++ ST    S+ K++V+++ + K    + K+ R
Sbjct: 115 SSSSDSEDEEKKQGKRRKKKKNRSYKSSQSSTHESESESKESVKKKKKSKDETEKEKDVR 174

Query: 196 QKKRKREK-----KELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVPEANGSAGKRSK 250
              +KR+K     K L  E+  E+   +  + +KK +  + E   E+V +      K+  
Sbjct: 175 SLSKKRKKSYPDDKPLSSESSSESDYEEDVQAKKKRRCEEREQAKEKVKKKKKKQHKKHS 234

Query: 251 KKKQRKDSASEE 262
           KKK++K  +S +
Sbjct: 235 KKKKKKSGSSHK 246



 Score = 39.3 bits (90), Expect = 0.006
 Identities = 41/185 (22%), Positives = 74/185 (40%), Gaps = 16/185 (8%)

Query: 160 NPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQK 219
           NP A    + P   V   ++   +     R   EE +K+ + +K   K     E   N+ 
Sbjct: 12  NPIAMARWRGPTQSVGPTIQ---DYLNRPRPTWEEVKKQLENKKTGSKALAEFEEKMNEN 68

Query: 220 PKKRKKGQEADLEAGGEEVPEANGSAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVE 279
            KK       +LE   E++   N S+ K+ ++KK+RK  +    +   +       S+ E
Sbjct: 69  WKK-------ELEKSREKLLSGNESSSKKRERKKKRKKKSCRSSSSSSSSDSSSSSSDSE 121

Query: 280 TDSKK----KKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITIKKLRKK 335
            + KK    +K K     +  +    E+ ++ K + K   K+  K   + E  ++ L KK
Sbjct: 122 DEEKKQGKRRKKKKNRSYKSSQSSTHESESESKESVKKKKKS--KDETEKEKDVRSLSKK 179

Query: 336 VLAQY 340
               Y
Sbjct: 180 RKKSY 184



 Score = 35.4 bits (80), Expect = 0.085
 Identities = 29/121 (23%), Positives = 57/121 (47%), Gaps = 12/121 (9%)

Query: 109 RKKAKFQNWMKNSLKVHNESILDQVWNIFSEASNSEPVNKEQDQRPLHPVANP-HAEIST 167
           RKK K +++  +    H ES  +   ++  +  + +   KE+D R L       + +   
Sbjct: 131 RKKKKNRSYKSSQSSTH-ESESESKESVKKKKKSKDETEKEKDVRSLSKKRKKSYPDDKP 189

Query: 168 KVPASKVKDAVEQQGEVKKNKR--ERKEERQKKRKREKKELKLENHQENSRNQKPKKRKK 225
               S  +   E+  + KK +R  ER++ ++K +K++KK+ K        ++ K KK+K 
Sbjct: 190 LSSESSSESDYEEDVQAKKKRRCEEREQAKEKVKKKKKKQHK--------KHSKKKKKKS 241

Query: 226 G 226
           G
Sbjct: 242 G 242


>gi|197927454 DEK oncogene isoform 2 [Homo sapiens]
          Length = 341

 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 66/266 (24%), Positives = 108/266 (40%), Gaps = 29/266 (10%)

Query: 84  LIKRPNVSPKVRELLEQISAFDNVPRKKAKFQNWMKNS-LKVHNESILDQVWNIFSEASN 142
           L  RP     V  L + +  F   P +K   Q   K   LK    ++L  +  +     +
Sbjct: 79  LYNRPGT---VSSLKKNVGQFSGFPFEKGSVQYKKKEEMLKKFRNAMLKSICEVLDLERS 135

Query: 143 SEPVNKEQDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQ-KKRKR 201
              VN E  +R L+ + +P       +P SK   +       K +K+ER      +K KR
Sbjct: 136 G--VNSELVKRILNFLMHPKPS-GKPLPKSKKTCS-------KGSKKERNSSGMARKAKR 185

Query: 202 EKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVPEANGSAGKRSKKKKQRKDSASE 261
            K    L +   +  ++K  K +   + D E+  EE P    +  ++ K+K   K   S 
Sbjct: 186 TKCPEILSDESSSDEDEKKNKEESSDDEDKES--EEEPPKKTAKREKPKQKATSKSKKSV 243

Query: 262 EEARV-----GAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIK 316
           + A V        K+ +  S+ E++S+      P   +  +P  DE         K TIK
Sbjct: 244 KSANVKKADSSTTKKNQNSSKKESESEDSSDDEPLIKKLKKPPTDE-------ELKETIK 296

Query: 317 AILKQAPDNEITIKKLRKKVLAQYYT 342
            +L  A   E+T+K++ KKV   Y T
Sbjct: 297 KLLASANLEEVTMKQICKKVYENYPT 322


>gi|4503249 DEK oncogene isoform 1 [Homo sapiens]
          Length = 375

 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 66/266 (24%), Positives = 108/266 (40%), Gaps = 29/266 (10%)

Query: 84  LIKRPNVSPKVRELLEQISAFDNVPRKKAKFQNWMKNS-LKVHNESILDQVWNIFSEASN 142
           L  RP     V  L + +  F   P +K   Q   K   LK    ++L  +  +     +
Sbjct: 113 LYNRPGT---VSSLKKNVGQFSGFPFEKGSVQYKKKEEMLKKFRNAMLKSICEVLDLERS 169

Query: 143 SEPVNKEQDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQ-KKRKR 201
              VN E  +R L+ + +P       +P SK   +       K +K+ER      +K KR
Sbjct: 170 G--VNSELVKRILNFLMHPKPS-GKPLPKSKKTCS-------KGSKKERNSSGMARKAKR 219

Query: 202 EKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVPEANGSAGKRSKKKKQRKDSASE 261
            K    L +   +  ++K  K +   + D E+  EE P    +  ++ K+K   K   S 
Sbjct: 220 TKCPEILSDESSSDEDEKKNKEESSDDEDKES--EEEPPKKTAKREKPKQKATSKSKKSV 277

Query: 262 EEARV-----GAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIK 316
           + A V        K+ +  S+ E++S+      P   +  +P  DE         K TIK
Sbjct: 278 KSANVKKADSSTTKKNQNSSKKESESEDSSDDEPLIKKLKKPPTDE-------ELKETIK 330

Query: 317 AILKQAPDNEITIKKLRKKVLAQYYT 342
            +L  A   E+T+K++ KKV   Y T
Sbjct: 331 KLLASANLEEVTMKQICKKVYENYPT 356


>gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]
          Length = 1564

 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 37/169 (21%), Positives = 78/169 (46%), Gaps = 13/169 (7%)

Query: 147 NKEQDQRPLHPVANP-------HAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKR 199
           N+E+DQRP  P+ +          E   +    +V D  +++   +  +RER  ER+++R
Sbjct: 634 NRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERERDRERERER 693

Query: 200 KREK-----KELKLENHQENSR-NQKPKKRKKGQEADLEAGGEEVPEANGSAGKRSKKKK 253
           +RE+     KE +LE  +   R  ++ K+R + ++ D +   E   E      K  ++++
Sbjct: 694 ERERDREREKERELERERAREREREREKERDRERDRDRDHDRERERERERDREKERERER 753

Query: 254 QRKDSASEEEARVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDE 302
           + ++   E E      + + R    E D ++++ +  E  + G  +  E
Sbjct: 754 EERERERERERERERERERERERARERDKERERQRDWEDKDKGRDDRRE 802



 Score = 46.2 bits (108), Expect = 5e-05
 Identities = 41/157 (26%), Positives = 67/157 (42%), Gaps = 18/157 (11%)

Query: 148  KEQDQRPLHPVANP-HAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKEL 206
            KE+D++P    ++  + E   K   S V D   +Q E+ ++ R R ++     + E +E 
Sbjct: 890  KEEDRKPERKESSRRYEEQELKEKVSSV-DKQREQTEILESSRMRAQDIIGHHQSEDRET 948

Query: 207  KLENHQENSRN----QKPKKRKKGQEADLEAGGEEVPEANG------------SAGKRSK 250
                H EN +     +KP K+KK  +  +E G  E    +G            S  K+ K
Sbjct: 949  SDRAHDENKKKAKIQKKPIKKKKEDDVGIERGNIETTSEDGQVFSPKKGQKKKSIEKKRK 1008

Query: 251  KKKQRKDSASEEEARVGAGKRKRRHSEVETDSKKKKM 287
            K K   D + EE A+    KR  R   + T  +  +M
Sbjct: 1009 KSKGDSDISDEEAAQQSKKKRGPRTPPITTKEELVEM 1045



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 31/103 (30%), Positives = 59/103 (57%), Gaps = 10/103 (9%)

Query: 179 EQQGEVKKNKRERKEERQKKRKREK-KELKLENHQENSRNQKPKKRKKGQEADLEAGGEE 237
           E++ E ++ +RER+ ER+++R+RE+ +E   E  +E  R +  + + KG++ D     EE
Sbjct: 748 EREREREERERERERERERERERERERERARERDKERERQRDWEDKDKGRD-DRREKREE 806

Query: 238 VPE----ANGSAGKRSKKKKQRKDSASEEEARVGAGKRKRRHS 276
           + E     +G   ++SKK+ + + S S  +    + KR+R HS
Sbjct: 807 IREDRNPRDGHDERKSKKRYRNEGSPSPRQ----SPKRRREHS 845



 Score = 36.2 bits (82), Expect = 0.050
 Identities = 44/209 (21%), Positives = 91/209 (43%), Gaps = 25/209 (11%)

Query: 185 KKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVPEANGS 244
           ++  RER +ER+++R  E K+   ++ +E  + ++ ++ +  ++   E   ++     GS
Sbjct: 774 RERARERDKERERQRDWEDKDKGRDDRRE--KREEIREDRNPRDGHDERKSKKRYRNEGS 831

Query: 245 AGKRSKKKKQRKDSASEEEARVGAGKRKRRH--SEVETDSKKKKMK---LPEHPEGGEPE 299
              R   K++R+ S   +    G  K ++    S+V    + + +    L E  +G   E
Sbjct: 832 PSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKE 891

Query: 300 DDEAPAKGKFN-------WKGTIKAILKQAPDNEI-TIKKLRKKVLAQYYTVTDEH--HR 349
           +D  P + + +        K  + ++ KQ    EI    ++R + +  ++   D     R
Sbjct: 892 EDRKPERKESSRRYEEQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDR 951

Query: 350 SEEELLVIFNK---KISKNPTFKLLKDKV 375
           + +E     NK   KI K P  K  +D V
Sbjct: 952 AHDE-----NKKKAKIQKKPIKKKKEDDV 975



 Score = 33.5 bits (75), Expect = 0.32
 Identities = 22/116 (18%), Positives = 55/116 (47%), Gaps = 5/116 (4%)

Query: 179 EQQGEVKKNK----RERKEERQKKRKREKKELKLENHQENSR-NQKPKKRKKGQEADLEA 233
           E + E++ ++    R R  E  +K  R  +  ++++H  NS  +   + R    E D   
Sbjct: 550 ESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYP 609

Query: 234 GGEEVPEANGSAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETDSKKKKMKL 289
             +   +A  S+ +R   ++ R+D+   ++      + + R+ E+E D ++++ ++
Sbjct: 610 ERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRV 665



 Score = 33.1 bits (74), Expect = 0.42
 Identities = 22/119 (18%), Positives = 49/119 (41%), Gaps = 2/119 (1%)

Query: 185 KKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVPEANGS 244
           +K    R     +++ R   E   ++H      ++  + K+ +E D     E   E + S
Sbjct: 384 RKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSRE--EREYEQDQS 441

Query: 245 AGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEA 303
           + +  +  ++ +D     +AR    +R+ R S    DS++ +    +  E  +P D  +
Sbjct: 442 SSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRS 500



 Score = 32.7 bits (73), Expect = 0.55
 Identities = 34/160 (21%), Positives = 69/160 (43%), Gaps = 14/160 (8%)

Query: 145 PVNKEQDQRPLHPVANPHAEISTKVPASKVKDAV----EQQGEVKKNKRERKEERQKKRK 200
           P+ +     P H +++P  + S     S +++      E+  +    + ER+E+ + KR 
Sbjct: 366 PLRRSASPYPSHSLSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRD 425

Query: 201 REK---KELKLENHQENSR----NQKPKKRKKGQEADLEAGGEEVPEANGSAGKRSKKKK 253
           REK   +E + E  Q +SR    +++P+  +  ++A       E+ ++      R  +  
Sbjct: 426 REKDSREEREYEQDQSSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDY 485

Query: 254 QR--KDSASEEEARVGAGKRKRRHSEVETDSKKKKMKLPE 291
            R  K+S    ++R        R  E   D+ +K+   PE
Sbjct: 486 SRDTKESRDPRDSRSTRDAHDYRDRE-GRDTHRKEDTYPE 524



 Score = 32.0 bits (71), Expect = 0.94
 Identities = 36/136 (26%), Positives = 60/136 (44%), Gaps = 14/136 (10%)

Query: 164 EISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKK----ELKLENHQENSRNQK 219
           E+S +V  SK+  +   +   K  KR+   +     K+++K       L + Q NS+  +
Sbjct: 196 EVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQ 255

Query: 220 PKKRKKGQEADLEAGGEEVPEANGSAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVE 279
            K  KKG      +    +PE + + GK+ K+K + KD   EE+ R G    K R  + E
Sbjct: 256 SK--KKGPRT--PSPPPPIPE-DIALGKKYKEKYKVKDRI-EEKTRDG----KDRGRDFE 305

Query: 280 TDSKKKKMKLPEHPEG 295
              +K+       P G
Sbjct: 306 RQREKRDKPRSTSPAG 321



 Score = 30.4 bits (67), Expect = 2.7
 Identities = 23/130 (17%), Positives = 59/130 (45%), Gaps = 5/130 (3%)

Query: 175 KDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQ----ENSRNQKPKKRKKGQEAD 230
           +D  +Q  +    +R  + +R+  R+R+++      HQ    E  R+++ ++R+  +  D
Sbjct: 611 RDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDD 670

Query: 231 -LEAGGEEVPEANGSAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETDSKKKKMKL 289
             +    E         +R +++++ +D   E+E  +   + + R  E E +  +++ + 
Sbjct: 671 RRDERARERDRERERDRERERERERERDREREKERELERERAREREREREKERDRERDRD 730

Query: 290 PEHPEGGEPE 299
            +H    E E
Sbjct: 731 RDHDRERERE 740



 Score = 29.3 bits (64), Expect = 6.1
 Identities = 21/113 (18%), Positives = 46/113 (40%), Gaps = 1/113 (0%)

Query: 188 KRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVPEANGSAGK 247
           +R+R  ER  + +      +  + + + R+ + + ++       +   +E+        +
Sbjct: 604 ERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREER 663

Query: 248 RSKKKKQRKDSASEEEARVGAGKRKR-RHSEVETDSKKKKMKLPEHPEGGEPE 299
           R  +   R+D  + E  R     R+R R  E E D +++K +  E     E E
Sbjct: 664 RVDRVDDRRDERARERDRERERDRERERERERERDREREKERELERERARERE 716



 Score = 29.3 bits (64), Expect = 6.1
 Identities = 34/169 (20%), Positives = 72/169 (42%), Gaps = 12/169 (7%)

Query: 95   RELLEQISAFDNVPRKKAKFQNWMKNSLKVHNESILDQVWNIFSEASN-SEPVNKEQDQR 153
            +EL E++S+ D     K + Q  +  S ++  + I+    +   E S+ +   NK++ + 
Sbjct: 908  QELKEKVSSVD-----KQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKI 962

Query: 154  PLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQE 213
               P+     E    +    ++   E        K ++K+  +KKRK+ K +  + + + 
Sbjct: 963  QKKPIKKKK-EDDVGIERGNIETTSEDGQVFSPKKGQKKKSIEKKRKKSKGDSDISDEEA 1021

Query: 214  NSRNQKPKKRKKGQEADLEAGGEEVPE-ANGSAGKRSKKKKQRKDSASE 261
              ++    K+K+G         EE+ E  NG  G     +K+   + S+
Sbjct: 1022 AQQS----KKKRGPRTPPITTKEELVEMCNGKNGILEDSQKKEDTAFSD 1066



 Score = 28.9 bits (63), Expect = 8.0
 Identities = 30/144 (20%), Positives = 57/144 (39%), Gaps = 18/144 (12%)

Query: 193  EERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVPEANGSAGKRSKKK 252
            E+RQ + K E +  K E  + + R ++ + ++K    D +    E+ E++    +     
Sbjct: 883  EDRQGRWKEEDR--KPERKESSRRYEEQELKEKVSSVDKQREQTEILESSRMRAQDIIGH 940

Query: 253  KQRKDSASEEEARVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWK 312
             Q +D  + + A                D  KKK K+ + P   + EDD    +G     
Sbjct: 941  HQSEDRETSDRAH---------------DENKKKAKIQKKPIKKKKEDDVGIERGNIETT 985

Query: 313  GTIKAILK-QAPDNEITIKKLRKK 335
                 +   +    + +I+K RKK
Sbjct: 986  SEDGQVFSPKKGQKKKSIEKKRKK 1009


>gi|91206454 hypothetical protein LOC257415 isoform 2 [Homo sapiens]
          Length = 237

 Score = 53.1 bits (126), Expect = 4e-07
 Identities = 59/225 (26%), Positives = 99/225 (44%), Gaps = 33/225 (14%)

Query: 81  ISELIKRPNVSPKVRELLEQISAFDNVPRKKAKFQ-----NWMKNSLKVHNESILDQVWN 135
           I + + RP   P   E+ EQ+       +  A+F+     NW K  L+ H E +L     
Sbjct: 20  IQDYLNRPR--PTWEEVKEQLEKKKKGSKALAEFEEKMNENW-KKELEKHREKLLSG--- 73

Query: 136 IFSEASNSEPVNKEQDQRPLHPVANPHAEIS-TKVPASKVKDAVEQQGEVKKNKRERK-- 192
             SE+S+ +   K+++++     ++  +  S +   +S  +D  ++QG+ +K K+ R   
Sbjct: 74  --SESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHK 131

Query: 193 ---------EERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVPEANG 243
                    E   K   ++KK+ K    +E       KKRK   E D     E + E+  
Sbjct: 132 SSESSMSETESDSKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSE-DKPLSSESLSESEY 190

Query: 244 SAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETDSKKKKMK 288
               R+KKKK    S+ E E      K+K++H +    SKKKK K
Sbjct: 191 IEEVRAKKKK----SSEEREKATEKTKKKKKHKK---HSKKKKKK 228



 Score = 48.1 bits (113), Expect = 1e-05
 Identities = 46/184 (25%), Positives = 71/184 (38%), Gaps = 31/184 (16%)

Query: 170 PASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQE---------NSRNQKP 220
           P    ++  EQ  + KK  +   E  +K  +  KKEL  E H+E         + + Q+ 
Sbjct: 27  PRPTWEEVKEQLEKKKKGSKALAEFEEKMNENWKKEL--EKHREKLLSGSESSSKKRQRK 84

Query: 221 KKRKK---------GQEADLEAGGEEVPEANGSAGKRSKKKKQRKDSASEEEARVGAGKR 271
           KK KK            +D  +   +  + +   GKR KKKK R   +SE          
Sbjct: 85  KKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSM------- 137

Query: 272 KRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITIKK 331
               SE E+DSK    K  +  +G E E D      K       K +  ++      I++
Sbjct: 138 ----SETESDSKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEE 193

Query: 332 LRKK 335
           +R K
Sbjct: 194 VRAK 197



 Score = 38.1 bits (87), Expect = 0.013
 Identities = 46/202 (22%), Positives = 89/202 (44%), Gaps = 12/202 (5%)

Query: 66  KTHKGDIKQQAWIQKISELIKRPNVSPKVRELLEQISAFDNVPRKKAKFQNWMKNSLKVH 125
           K  KG      + +K++E  K+     K RE L  +S  ++  +K+ + +   K S +  
Sbjct: 40  KKKKGSKALAEFEEKMNENWKKE--LEKHREKL--LSGSESSSKKRQRKKKEKKKSGRYS 95

Query: 126 NESILDQVWNIFSEASNSEPVNKEQDQRPLHPVANPH--AEISTKVPASKVKDAVEQQGE 183
           + S      +  S +S+SE  +K+Q +R        H  +E S     S  KD+++++ +
Sbjct: 96  SSSSSSS--DSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKK 153

Query: 184 VKKNKRERKEERQKKRKR----EKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVP 239
            K    + K+ +   +KR    E K L  E+  E+   ++ + +KK    + E   E+  
Sbjct: 154 SKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKATEKTK 213

Query: 240 EANGSAGKRSKKKKQRKDSASE 261
           +         KKKK+   S+ +
Sbjct: 214 KKKKHKKHSKKKKKKAASSSPD 235


>gi|91206456 hypothetical protein LOC257415 isoform 1 [Homo sapiens]
          Length = 247

 Score = 53.1 bits (126), Expect = 4e-07
 Identities = 59/225 (26%), Positives = 99/225 (44%), Gaps = 33/225 (14%)

Query: 81  ISELIKRPNVSPKVRELLEQISAFDNVPRKKAKFQ-----NWMKNSLKVHNESILDQVWN 135
           I + + RP   P   E+ EQ+       +  A+F+     NW K  L+ H E +L     
Sbjct: 30  IQDYLNRPR--PTWEEVKEQLEKKKKGSKALAEFEEKMNENW-KKELEKHREKLLSG--- 83

Query: 136 IFSEASNSEPVNKEQDQRPLHPVANPHAEIS-TKVPASKVKDAVEQQGEVKKNKRERK-- 192
             SE+S+ +   K+++++     ++  +  S +   +S  +D  ++QG+ +K K+ R   
Sbjct: 84  --SESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHK 141

Query: 193 ---------EERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVPEANG 243
                    E   K   ++KK+ K    +E       KKRK   E D     E + E+  
Sbjct: 142 SSESSMSETESDSKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSE-DKPLSSESLSESEY 200

Query: 244 SAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETDSKKKKMK 288
               R+KKKK    S+ E E      K+K++H +    SKKKK K
Sbjct: 201 IEEVRAKKKK----SSEEREKATEKTKKKKKHKK---HSKKKKKK 238



 Score = 48.1 bits (113), Expect = 1e-05
 Identities = 46/184 (25%), Positives = 71/184 (38%), Gaps = 31/184 (16%)

Query: 170 PASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQE---------NSRNQKP 220
           P    ++  EQ  + KK  +   E  +K  +  KKEL  E H+E         + + Q+ 
Sbjct: 37  PRPTWEEVKEQLEKKKKGSKALAEFEEKMNENWKKEL--EKHREKLLSGSESSSKKRQRK 94

Query: 221 KKRKK---------GQEADLEAGGEEVPEANGSAGKRSKKKKQRKDSASEEEARVGAGKR 271
           KK KK            +D  +   +  + +   GKR KKKK R   +SE          
Sbjct: 95  KKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSM------- 147

Query: 272 KRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITIKK 331
               SE E+DSK    K  +  +G E E D      K       K +  ++      I++
Sbjct: 148 ----SETESDSKDSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEE 203

Query: 332 LRKK 335
           +R K
Sbjct: 204 VRAK 207



 Score = 38.1 bits (87), Expect = 0.013
 Identities = 46/202 (22%), Positives = 89/202 (44%), Gaps = 12/202 (5%)

Query: 66  KTHKGDIKQQAWIQKISELIKRPNVSPKVRELLEQISAFDNVPRKKAKFQNWMKNSLKVH 125
           K  KG      + +K++E  K+     K RE L  +S  ++  +K+ + +   K S +  
Sbjct: 50  KKKKGSKALAEFEEKMNENWKKE--LEKHREKL--LSGSESSSKKRQRKKKEKKKSGRYS 105

Query: 126 NESILDQVWNIFSEASNSEPVNKEQDQRPLHPVANPH--AEISTKVPASKVKDAVEQQGE 183
           + S      +  S +S+SE  +K+Q +R        H  +E S     S  KD+++++ +
Sbjct: 106 SSSSSSS--DSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKK 163

Query: 184 VKKNKRERKEERQKKRKR----EKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVP 239
            K    + K+ +   +KR    E K L  E+  E+   ++ + +KK    + E   E+  
Sbjct: 164 SKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKATEKTK 223

Query: 240 EANGSAGKRSKKKKQRKDSASE 261
           +         KKKK+   S+ +
Sbjct: 224 KKKKHKKHSKKKKKKAASSSPD 245


>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
          Length = 843

 Score = 52.8 bits (125), Expect = 5e-07
 Identities = 40/176 (22%), Positives = 82/176 (46%), Gaps = 18/176 (10%)

Query: 146 VNKEQDQRPL-HPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKK 204
           +  E+D+R L     +   +   K+   K K   E+Q E++K +RER+ ER+++R+R ++
Sbjct: 267 IEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQ-EIEKERRERERERERERERRER 325

Query: 205 ELKLENHQENSRNQ---------------KPKKRKKGQEADLEAGGEEVPEANGSAGKRS 249
           E + E  +E  + +               K + R + +E D +   E   + N     RS
Sbjct: 326 EREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDR-SRS 384

Query: 250 KKKKQRKDSASEEEARVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPA 305
           ++K + ++   E E      + + R  E E + ++++ +  E  +  + E+DE  A
Sbjct: 385 REKSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDA 440



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 22/107 (20%), Positives = 59/107 (55%), Gaps = 5/107 (4%)

Query: 185 KKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVPEANGS 244
           K   RER+ ER+++R+RE++  +    +     ++ ++R+K ++ D E   E+  E    
Sbjct: 387 KSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYER--- 443

Query: 245 AGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETDSKKKKMKLPE 291
             ++ ++K + K++A +E  +    + +++  E E ++++++ +  E
Sbjct: 444 --RKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRRE 488



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 52/244 (21%), Positives = 102/244 (41%), Gaps = 50/244 (20%)

Query: 172 SKVKDAVEQQGEVKKNKRERKEERQKKRKREK--------------------------KE 205
           S+ K    ++   ++ +RER+ ER+++R+RE+                          + 
Sbjct: 384 SREKSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYER 443

Query: 206 LKLEN--------HQENSRNQKPKKRKKGQEADLEAGGEEVPEANGSAGKRSKKKKQ--- 254
            KLE         +QE  +N + ++RKK +E + EA  EE  E      K +K+ K+   
Sbjct: 444 RKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREE--ERRREMAKEAKRLKEFLE 501

Query: 255 -RKDSASEEEARVGAGKRKR---RHSEVETDSKKKKMKLPEHPE-------GGEPEDDEA 303
              D   + +   G+  +KR   R  E+E D + +K +  E  E        G P+ D  
Sbjct: 502 DYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAE 561

Query: 304 PAKGKFNWKGTIKAILKQAPDNEITIKKLRKKVLAQYYTVTDEHHRSEEELLVIFNKKIS 363
             + +   +   +  +KQ P++E   ++ ++K   +   + +E    ++  L    + IS
Sbjct: 562 LQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQKPCLKPTLRPIS 621

Query: 364 KNPT 367
             P+
Sbjct: 622 SAPS 625



 Score = 38.9 bits (89), Expect = 0.008
 Identities = 30/161 (18%), Positives = 66/161 (40%), Gaps = 7/161 (4%)

Query: 148 KEQDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELK 207
           +E+++R          E   +    + ++    +   K+  R+R  ER + R RE+   +
Sbjct: 318 RERERREREREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDR 377

Query: 208 LENHQENSRNQKPKKRKKGQEADLEAGGEEVPEANGSAGK-----RSKKKKQRKDSASEE 262
            ++   +    + ++R++ +E + E   E   E      +     R ++K +++D   +E
Sbjct: 378 NKDRSRSREKSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDE 437

Query: 263 EARVGAGK--RKRRHSEVETDSKKKKMKLPEHPEGGEPEDD 301
           E      K  RK R  E     + K  ++ E  +  E E +
Sbjct: 438 EDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKE 478



 Score = 37.4 bits (85), Expect = 0.022
 Identities = 27/152 (17%), Positives = 64/152 (42%), Gaps = 10/152 (6%)

Query: 144 EPVNKEQDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREK 203
           E   KE++++ +            +    + ++   ++   ++ ++ER+ ER++ R R++
Sbjct: 294 EKGKKEKERQEIEKERRERERERERERERREREREREREREREKEKERERERERDRDRDR 353

Query: 204 -KELKLENHQENSRNQ---------KPKKRKKGQEADLEAGGEEVPEANGSAGKRSKKKK 253
            KE   +  +E  R++         K + R + +  D E   E   E      +  ++++
Sbjct: 354 TKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERER 413

Query: 254 QRKDSASEEEARVGAGKRKRRHSEVETDSKKK 285
           +R+     E  R    KR R   E +   ++K
Sbjct: 414 EREREREREREREKDKKRDREEDEEDAYERRK 445



 Score = 35.4 bits (80), Expect = 0.085
 Identities = 39/199 (19%), Positives = 80/199 (40%), Gaps = 36/199 (18%)

Query: 158 VANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSR- 216
           +A  H +   ++   + +    +Q ++K+     +EE +K+ K EK+E  +E  +E  + 
Sbjct: 551 LAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQK 610

Query: 217 ----------NQKPKKRKKGQEADLEAGGEE------VPEANGSAGKRSKKKKQR----- 255
                     +  P        A     G+E      +P  N    ++ ++ + +     
Sbjct: 611 PCLKPTLRPISSAPSVSSASGNATPNTPGDESPCGIIIPHENSPDQQQPEEHRPKIGLSL 670

Query: 256 KDSASEEEARVGAGKRKR--------RHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKG 307
           K  AS    +  + KRK+        +  + ++D   +K KL     G   EDD+   KG
Sbjct: 671 KLGASNSPGQPNSVKRKKLPVDSVFNKFEDEDSDDVPRKRKLVPLDYG---EDDKNATKG 727

Query: 308 KFNW---KGTIKAILKQAP 323
             N    +  IK+++++ P
Sbjct: 728 TVNTEEKRKHIKSLIEKIP 746


>gi|52426743 cisplatin resistance-associated overexpressed protein
           [Homo sapiens]
          Length = 432

 Score = 52.8 bits (125), Expect = 5e-07
 Identities = 40/224 (17%), Positives = 100/224 (44%), Gaps = 24/224 (10%)

Query: 65  GKTHKGDIKQQAWIQKISELIKRPNVSPKVRELLEQISAFDNVPRKKAKFQNWMKNSLKV 124
           GK H G  K +A ++++ E +++    P   E L++    +   R+K + +   +   K 
Sbjct: 214 GKQHMGYAKIKATVEELKEKLRKRTEEPDRDERLKKEKQ-EREEREKEREREREERERKR 272

Query: 125 HNESILDQVWNIFSEASNSEPVNKEQDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEV 184
             E           E    +   +++++R      + H+  ++    S+ +D        
Sbjct: 273 RRE-----------EEEREKERARDRERRKRSRSRSRHSSRTSDRRCSRSRD-------- 313

Query: 185 KKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVPEANGS 244
             +KR R  ER++ R R+++  +  +  E     + + R++ +  D ++        +  
Sbjct: 314 --HKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDRE 371

Query: 245 AGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETDSKKKKMK 288
             ++SK+K++R   + ++++ V +G R+++  +  T+SK+   K
Sbjct: 372 QDRKSKEKEKR--GSDDKKSSVKSGSREKQSEDTNTESKESDTK 413



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 29/123 (23%), Positives = 59/123 (47%), Gaps = 2/123 (1%)

Query: 172 SKVKDAVEQQGEVKKNKRER--KEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEA 229
           +K+K  VE+  E  + + E   ++ER KK K+E++E + E  +E    ++ ++R++ +  
Sbjct: 221 AKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEEERE 280

Query: 230 DLEAGGEEVPEANGSAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETDSKKKKMKL 289
              A   E  + + S  + S +   R+ S S +  R  + +R+R  S     S+      
Sbjct: 281 KERARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSE 340

Query: 290 PEH 292
            +H
Sbjct: 341 RKH 343



 Score = 28.9 bits (63), Expect = 8.0
 Identities = 13/79 (16%), Positives = 38/79 (48%), Gaps = 1/79 (1%)

Query: 185 KKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKR-KKGQEADLEAGGEEVPEANG 243
           +   R+R+  + + RK  K   K  + +++ ++++ +KR    +++ +++G  E    + 
Sbjct: 344 RSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDT 403

Query: 244 SAGKRSKKKKQRKDSASEE 262
           +   +    K   +  SE+
Sbjct: 404 NTESKESDTKNEVNGTSED 422


>gi|19923485 cisplatin resistance-associated overexpressed protein
           [Homo sapiens]
          Length = 432

 Score = 52.8 bits (125), Expect = 5e-07
 Identities = 40/224 (17%), Positives = 100/224 (44%), Gaps = 24/224 (10%)

Query: 65  GKTHKGDIKQQAWIQKISELIKRPNVSPKVRELLEQISAFDNVPRKKAKFQNWMKNSLKV 124
           GK H G  K +A ++++ E +++    P   E L++    +   R+K + +   +   K 
Sbjct: 214 GKQHMGYAKIKATVEELKEKLRKRTEEPDRDERLKKEKQ-EREEREKEREREREERERKR 272

Query: 125 HNESILDQVWNIFSEASNSEPVNKEQDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEV 184
             E           E    +   +++++R      + H+  ++    S+ +D        
Sbjct: 273 RRE-----------EEEREKERARDRERRKRSRSRSRHSSRTSDRRCSRSRD-------- 313

Query: 185 KKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVPEANGS 244
             +KR R  ER++ R R+++  +  +  E     + + R++ +  D ++        +  
Sbjct: 314 --HKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDRE 371

Query: 245 AGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETDSKKKKMK 288
             ++SK+K++R   + ++++ V +G R+++  +  T+SK+   K
Sbjct: 372 QDRKSKEKEKR--GSDDKKSSVKSGSREKQSEDTNTESKESDTK 413



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 29/123 (23%), Positives = 59/123 (47%), Gaps = 2/123 (1%)

Query: 172 SKVKDAVEQQGEVKKNKRER--KEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEA 229
           +K+K  VE+  E  + + E   ++ER KK K+E++E + E  +E    ++ ++R++ +  
Sbjct: 221 AKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEEERE 280

Query: 230 DLEAGGEEVPEANGSAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETDSKKKKMKL 289
              A   E  + + S  + S +   R+ S S +  R  + +R+R  S     S+      
Sbjct: 281 KERARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSE 340

Query: 290 PEH 292
            +H
Sbjct: 341 RKH 343



 Score = 28.9 bits (63), Expect = 8.0
 Identities = 13/79 (16%), Positives = 38/79 (48%), Gaps = 1/79 (1%)

Query: 185 KKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKR-KKGQEADLEAGGEEVPEANG 243
           +   R+R+  + + RK  K   K  + +++ ++++ +KR    +++ +++G  E    + 
Sbjct: 344 RSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDT 403

Query: 244 SAGKRSKKKKQRKDSASEE 262
           +   +    K   +  SE+
Sbjct: 404 NTESKESDTKNEVNGTSED 422


>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
           [Homo sapiens]
          Length = 916

 Score = 52.4 bits (124), Expect = 7e-07
 Identities = 64/266 (24%), Positives = 107/266 (40%), Gaps = 34/266 (12%)

Query: 139 EASNSEPVNKEQ-DQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQK 197
           E     PV K   +++   PV+    E   K P  K     E + + +  K E+KEE +K
Sbjct: 649 EEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPK-SPVEEAKSKAEVGKGEQKEEEEK 707

Query: 198 KRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVPEANGSAGKRSKKKKQR-- 255
           + K   KE K+E  +E  ++  P+K+K       EA  E V           K+ K+   
Sbjct: 708 EVKEAPKEEKVEKKEEKPKD-VPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGK 766

Query: 256 --KDSASEEEARVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAK--GKFNW 311
             +    +E+A    G  +    +    S+K+ + +    EG E  + E   K  G+   
Sbjct: 767 PLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEE 826

Query: 312 KGTIKAILKQAPDNE-----------ITIKKLRK----------KVLAQYYTVT---DEH 347
           KG +   L  +P +E           +  K + K          K + +  TVT   +EH
Sbjct: 827 KGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITSEGGDGATKYITKSVTVTQKVEEH 886

Query: 348 HRSEEELLVIFNKKISKNPTFKLLKD 373
             + EE LV   KK+ K  +  ++K+
Sbjct: 887 EETFEEKLV-STKKVEKVTSHAIVKE 911



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 49/230 (21%), Positives = 94/230 (40%), Gaps = 31/230 (13%)

Query: 81  ISELIKRPNV-SPKVR---ELLEQISAFDNVPRKKAKFQNWMKNSLKVHNESILDQVWNI 136
           IS  I++P V +PK++   + +E+I     V  +K++    M+ +L    E +   +   
Sbjct: 432 ISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSE----MEEALTAITEELAVSMKEE 487

Query: 137 FSEASNSEPVNKEQDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQ 196
             EA+      +E+++ P         E   +  A+K         EVK+ + E++EE  
Sbjct: 488 KKEAA------EEKEEEP---------EAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEG 532

Query: 197 KKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVPEANGSAGKRSKKKKQRK 256
           ++ + E+ E    +  E   ++K    +K +    E   E   E   +  K  KK +++ 
Sbjct: 533 QEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKS 592

Query: 257 DSASEEEARVGAGKRKRRH--------SEVETDSKKKKMKLPEHPEGGEP 298
           +  + +E  V   K ++          S VE   K    K P   +G  P
Sbjct: 593 EEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSP 642



 Score = 38.9 bits (89), Expect = 0.008
 Identities = 28/124 (22%), Positives = 63/124 (50%), Gaps = 2/124 (1%)

Query: 184 VKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVPEANG 243
           +K+ K+E  EE++++ + E++E+  +     +   + K+ ++G++ + E   EE  E  G
Sbjct: 484 MKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKE-EEGEKEEEEGQEEEEEEDEG 542

Query: 244 SAGKRSKKKKQRKDSASE-EEARVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDE 302
           +   ++++    K+ +SE EE     G+ +      E ++K++K    +  E    E+  
Sbjct: 543 AKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELV 602

Query: 303 APAK 306
           A AK
Sbjct: 603 ADAK 606



 Score = 33.9 bits (76), Expect = 0.25
 Identities = 29/108 (26%), Positives = 48/108 (44%), Gaps = 7/108 (6%)

Query: 197 KKRKREKKELKLENH--QENSRNQKPKKRKKGQEADLEAGGEEVPEANGSAGKRSKKKKQ 254
           +K K E  +LK+++   +E     K +  K   E  L A  EE+  +     K + ++K+
Sbjct: 437 QKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKE 496

Query: 255 RKDSASEEEARVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDE 302
            +  A EEE        K    EV+ +  +K     E  EG E E++E
Sbjct: 497 EEPEAEEEEVAAKKSPVKATAPEVKEEEGEK-----EEEEGQEEEEEE 539



 Score = 33.9 bits (76), Expect = 0.25
 Identities = 31/133 (23%), Positives = 60/133 (45%), Gaps = 8/133 (6%)

Query: 175 KDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAG 234
           K+A E+    K+ + E +EE    +K   K    E  +E    ++ + +++ +E D E  
Sbjct: 489 KEAAEE----KEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEED-EGA 543

Query: 235 GEEVPEANGSAGKRSKKKKQRKDSASEEEARV-GAGKRKRRHSEVETDSKK--KKMKLPE 291
             +  E  GS  + S +K++ +    E EA   G     +   +VE  S++   K +L  
Sbjct: 544 KSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVA 603

Query: 292 HPEGGEPEDDEAP 304
             +  +PE  ++P
Sbjct: 604 DAKVEKPEKAKSP 616



 Score = 30.0 bits (66), Expect = 3.6
 Identities = 43/189 (22%), Positives = 78/189 (41%), Gaps = 30/189 (15%)

Query: 158 VANPHAEISTKVPASKVKDAVEQQGE--VKKNKRERK----------EERQKK------- 198
           VA+   E   K  +   K  VE++G+  V K+  E K          EE+ K        
Sbjct: 602 VADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPV 661

Query: 199 RKREKKELKLENHQENSRNQKPKKRKKGQEADLEAG-----GEEVPEANGSAGKRSKKKK 253
            ++ K  +     +E +++  PK   +  ++  E G      EE  E   +  +   +KK
Sbjct: 662 EEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKK 721

Query: 254 QRKDSASEEEARVGAGKRKRRHSEVETDSKKKKMKL-PEHPEGGEP-----EDDEAPAKG 307
           + K     E+ +  +  ++   +EV T +K  K+ L  E  E G+P     E ++A  +G
Sbjct: 722 EEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEG 781

Query: 308 KFNWKGTIK 316
               +G+ K
Sbjct: 782 GSEEEGSDK 790


>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
           [Homo sapiens]
          Length = 540

 Score = 52.4 bits (124), Expect = 7e-07
 Identities = 64/266 (24%), Positives = 107/266 (40%), Gaps = 34/266 (12%)

Query: 139 EASNSEPVNKEQ-DQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQK 197
           E     PV K   +++   PV+    E   K P  K     E + + +  K E+KEE +K
Sbjct: 273 EEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPK-SPVEEAKSKAEVGKGEQKEEEEK 331

Query: 198 KRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVPEANGSAGKRSKKKKQR-- 255
           + K   KE K+E  +E  ++  P+K+K       EA  E V           K+ K+   
Sbjct: 332 EVKEAPKEEKVEKKEEKPKD-VPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGK 390

Query: 256 --KDSASEEEARVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAK--GKFNW 311
             +    +E+A    G  +    +    S+K+ + +    EG E  + E   K  G+   
Sbjct: 391 PLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEE 450

Query: 312 KGTIKAILKQAPDNE-----------ITIKKLRK----------KVLAQYYTVT---DEH 347
           KG +   L  +P +E           +  K + K          K + +  TVT   +EH
Sbjct: 451 KGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITSEGGDGATKYITKSVTVTQKVEEH 510

Query: 348 HRSEEELLVIFNKKISKNPTFKLLKD 373
             + EE LV   KK+ K  +  ++K+
Sbjct: 511 EETFEEKLV-STKKVEKVTSHAIVKE 535



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 49/230 (21%), Positives = 94/230 (40%), Gaps = 31/230 (13%)

Query: 81  ISELIKRPNV-SPKVR---ELLEQISAFDNVPRKKAKFQNWMKNSLKVHNESILDQVWNI 136
           IS  I++P V +PK++   + +E+I     V  +K++    M+ +L    E +   +   
Sbjct: 56  ISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSE----MEEALTAITEELAVSMKEE 111

Query: 137 FSEASNSEPVNKEQDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQ 196
             EA+      +E+++ P         E   +  A+K         EVK+ + E++EE  
Sbjct: 112 KKEAA------EEKEEEP---------EAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEG 156

Query: 197 KKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVPEANGSAGKRSKKKKQRK 256
           ++ + E+ E    +  E   ++K    +K +    E   E   E   +  K  KK +++ 
Sbjct: 157 QEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKS 216

Query: 257 DSASEEEARVGAGKRKRRH--------SEVETDSKKKKMKLPEHPEGGEP 298
           +  + +E  V   K ++          S VE   K    K P   +G  P
Sbjct: 217 EEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSP 266



 Score = 38.9 bits (89), Expect = 0.008
 Identities = 28/124 (22%), Positives = 63/124 (50%), Gaps = 2/124 (1%)

Query: 184 VKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVPEANG 243
           +K+ K+E  EE++++ + E++E+  +     +   + K+ ++G++ + E   EE  E  G
Sbjct: 108 MKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKE-EEGEKEEEEGQEEEEEEDEG 166

Query: 244 SAGKRSKKKKQRKDSASE-EEARVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDE 302
           +   ++++    K+ +SE EE     G+ +      E ++K++K    +  E    E+  
Sbjct: 167 AKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELV 226

Query: 303 APAK 306
           A AK
Sbjct: 227 ADAK 230



 Score = 33.9 bits (76), Expect = 0.25
 Identities = 29/108 (26%), Positives = 48/108 (44%), Gaps = 7/108 (6%)

Query: 197 KKRKREKKELKLENH--QENSRNQKPKKRKKGQEADLEAGGEEVPEANGSAGKRSKKKKQ 254
           +K K E  +LK+++   +E     K +  K   E  L A  EE+  +     K + ++K+
Sbjct: 61  QKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKE 120

Query: 255 RKDSASEEEARVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDE 302
            +  A EEE        K    EV+ +  +K     E  EG E E++E
Sbjct: 121 EEPEAEEEEVAAKKSPVKATAPEVKEEEGEK-----EEEEGQEEEEEE 163



 Score = 33.9 bits (76), Expect = 0.25
 Identities = 31/133 (23%), Positives = 60/133 (45%), Gaps = 8/133 (6%)

Query: 175 KDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAG 234
           K+A E+    K+ + E +EE    +K   K    E  +E    ++ + +++ +E D E  
Sbjct: 113 KEAAEE----KEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEED-EGA 167

Query: 235 GEEVPEANGSAGKRSKKKKQRKDSASEEEARV-GAGKRKRRHSEVETDSKK--KKMKLPE 291
             +  E  GS  + S +K++ +    E EA   G     +   +VE  S++   K +L  
Sbjct: 168 KSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVA 227

Query: 292 HPEGGEPEDDEAP 304
             +  +PE  ++P
Sbjct: 228 DAKVEKPEKAKSP 240



 Score = 30.0 bits (66), Expect = 3.6
 Identities = 43/189 (22%), Positives = 78/189 (41%), Gaps = 30/189 (15%)

Query: 158 VANPHAEISTKVPASKVKDAVEQQGE--VKKNKRERK----------EERQKK------- 198
           VA+   E   K  +   K  VE++G+  V K+  E K          EE+ K        
Sbjct: 226 VADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPV 285

Query: 199 RKREKKELKLENHQENSRNQKPKKRKKGQEADLEAG-----GEEVPEANGSAGKRSKKKK 253
            ++ K  +     +E +++  PK   +  ++  E G      EE  E   +  +   +KK
Sbjct: 286 EEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKK 345

Query: 254 QRKDSASEEEARVGAGKRKRRHSEVETDSKKKKMKL-PEHPEGGEP-----EDDEAPAKG 307
           + K     E+ +  +  ++   +EV T +K  K+ L  E  E G+P     E ++A  +G
Sbjct: 346 EEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEG 405

Query: 308 KFNWKGTIK 316
               +G+ K
Sbjct: 406 GSEEEGSDK 414


>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
          Length = 793

 Score = 52.4 bits (124), Expect = 7e-07
 Identities = 48/211 (22%), Positives = 97/211 (45%), Gaps = 18/211 (8%)

Query: 139 EASNSEPVNKEQDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNK------RERK 192
           E S+ E + +E  +R     A   AE   ++ A + K   +++  ++  +      RER+
Sbjct: 250 EISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERR 309

Query: 193 EERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVPEANGSAGKRSKKK 252
           E  +++R RE+++   E  Q     +K    ++ +  + E    E  +      KR+ ++
Sbjct: 310 EAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEE 369

Query: 253 KQRKDSASEEEARVGAGKR-----KRRHSEVETDSKKKKM------KLPEHPEGGEPEDD 301
           +QR  +  EE+A+V   KR     +++H+  ET  K +K+      K     +  E +  
Sbjct: 370 RQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQ 429

Query: 302 EAPAKGKFNWKGT-IKAILKQAPDNEITIKK 331
            A  K +   KGT ++A  ++  +++ T KK
Sbjct: 430 TAVLKKQGEEKGTKVQAKREKLQEDKPTFKK 460



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 41/192 (21%), Positives = 85/192 (44%), Gaps = 8/192 (4%)

Query: 164 EISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKR 223
           + S  +P+ ++++   +    +K   E+ E RQ++ + E+ E   +++Q+N      + +
Sbjct: 127 DASLSLPSRRMQNDTAENETTEKE--EKSESRQERYEIEETETVTKSYQKNDWRDAEENK 184

Query: 224 KKGQEADLEAGGEEVPEANGSAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETDSK 283
           K+ +E + E   EE P+       + +   + K + S+EE  V + K  +  SE     +
Sbjct: 185 KEDKEKEEEE--EEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEE 242

Query: 284 KKKMKLPE--HPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITIKKLRKKVLAQYY 341
           +++    E  H E  E ED E     +   +   +  +K   D +I  +  R ++ A+  
Sbjct: 243 EREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADE--RARIEAEEK 300

Query: 342 TVTDEHHRSEEE 353
               E  R E E
Sbjct: 301 AAAQERERREAE 312



 Score = 40.8 bits (94), Expect = 0.002
 Identities = 55/250 (22%), Positives = 104/250 (41%), Gaps = 47/250 (18%)

Query: 55  DQKYGGKGYEGKTHKGDIKQQAWIQKISELIKRPNVSPKVRELLEQISAF---------- 104
           +QK  GK    K  + D  Q A ++K  E  K   V  K  +L E    F          
Sbjct: 410 EQKIEGKWVNEKKAQEDKLQTAVLKKQGEE-KGTKVQAKREKLQEDKPTFKKEEIKDEKI 468

Query: 105 --DNVPRKKAK-FQNWMKNSLKVHNES------ILDQVWNIFSEASNSEPVNKEQDQRPL 155
             D  P+++ K F +  K   +V +++       L    N FS       V+ ++     
Sbjct: 469 KKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKE----- 523

Query: 156 HPVANPHAEISTKVPASK-VKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQEN 214
                  AE + +V A K +++   ++GE +  + E+ +++Q++   E +ELK +  +  
Sbjct: 524 -------AEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERR 576

Query: 215 SRNQKPKKRKKGQEADLEAGGEEVPEANGSAGKRSKKKKQRKDSASEEEARVGAGKRKRR 274
              ++ ++R+K +EAD +               R +++K+R     E      A KR++ 
Sbjct: 577 KVLEEEEQRRKQEEADRKL--------------REEEEKRRLKEEIERRRAEAAEKRQKM 622

Query: 275 HSEVETDSKK 284
             +  +D KK
Sbjct: 623 PEDGLSDDKK 632



 Score = 40.0 bits (92), Expect = 0.003
 Identities = 27/96 (28%), Positives = 53/96 (55%), Gaps = 6/96 (6%)

Query: 173 KVKDAVEQQGEVKKNKRERK---EERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEA 229
           K ++A  +  E+KK + ER+   EE +++RK+E+ + KL   +E  R ++  +R++ + A
Sbjct: 557 KQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAA 616

Query: 230 DLEAGGEEVPEANGSAGKRSKKKKQRKDSASEEEAR 265
           +     +++PE   S  K+  K    K S+ + E R
Sbjct: 617 EKR---QKMPEDGLSDDKKPFKCFTPKGSSLKIEER 649



 Score = 39.3 bits (90), Expect = 0.006
 Identities = 40/192 (20%), Positives = 85/192 (44%), Gaps = 8/192 (4%)

Query: 138 SEASNSEPVNKEQDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVK--KNKRERKEER 195
           +E +  E   KE+++    P      E   +V   +     +++  V   KN +   EE 
Sbjct: 180 AEENKKEDKEKEEEEEE-KPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEP 238

Query: 196 QKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVPEANGS---AGKRSKKK 252
           +++ +RE+   ++ +H++    ++ K+R + + A LEA   E  +A      A +R++ +
Sbjct: 239 KQEEEREQGSDEISHHEK--MEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIE 296

Query: 253 KQRKDSASEEEARVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKGKFNWK 312
            + K +A E E R    + + R  E     +++++K  E     E +  +   K     +
Sbjct: 297 AEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEER 356

Query: 313 GTIKAILKQAPD 324
             IK   K+A +
Sbjct: 357 QRIKEEEKRAAE 368



 Score = 39.3 bits (90), Expect = 0.006
 Identities = 48/188 (25%), Positives = 77/188 (40%), Gaps = 34/188 (18%)

Query: 138 SEASNSEPVNKEQDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRE------- 190
           + A   E    E+ +R        HA   TK+   KV+  +E +   +K  +E       
Sbjct: 373 ARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAV 432

Query: 191 -RKEERQKKRKREKKELKLEN-----HQENSRNQKPKKRKKGQE-----ADLEAGGEEVP 239
            +K+  +K  K + K  KL+       +E  +++K KK K+ +E      D + G  EV 
Sbjct: 433 LKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVK 492

Query: 240 EANGSAGKRSKKKKQR-------KDSASEEEA----RVGAGKR----KRRHSEVETDS-K 283
             NG       K  +        + S   +EA    +V AGKR    +RR  E E++  +
Sbjct: 493 SQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFE 552

Query: 284 KKKMKLPE 291
           K K K  E
Sbjct: 553 KLKQKQQE 560



 Score = 30.4 bits (67), Expect = 2.7
 Identities = 37/176 (21%), Positives = 72/176 (40%), Gaps = 28/176 (15%)

Query: 141 SNSEPVNKEQDQRPLHPVANP-HAEISTKVPASKVKDA-----VEQQGEVKKNKR-ERKE 193
           +  E + ++Q++  L  V +         VP  + K       VE   E    +R  R+E
Sbjct: 45  ARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARRE 104

Query: 194 ERQKKRKRE--KKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVPEANGSAGKRSKK 251
           ER++KR +E  +++ + +    ++    P +R +   A+           N +  K  K 
Sbjct: 105 ERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAE-----------NETTEKEEKS 153

Query: 252 KKQRKDSASEEEARVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAKG 307
           + +++    EE   V    +K    + E + K+ K K        E E++E P +G
Sbjct: 154 ESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEK--------EEEEEEKPKRG 201


>gi|115298682 HBxAg transactivated protein 2 [Homo sapiens]
          Length = 2817

 Score = 52.4 bits (124), Expect = 7e-07
 Identities = 40/132 (30%), Positives = 68/132 (51%), Gaps = 12/132 (9%)

Query: 171 ASKVKDAVEQQGEVKKN---KRERKEERQKKRKREKKELKLENHQENSR-NQKPKKRKKG 226
           A K+K   E+ G ++K    +  R+ ER+K+R+REK+   LE  QE  R  ++ K R++ 
Sbjct: 482 AEKLKRLDEKLGILEKQPSPEEIREREREKEREREKE---LEKEQEQEREKEREKDRERQ 538

Query: 227 QEADLEAGGEEVPEANGSAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETDSKKKK 286
           QE + E   E+  +      +  K++KQ K+   E +       +K +  E E + +K++
Sbjct: 539 QEKEKELEKEQEKQR-----EMEKERKQEKEKELERQKEKEKELQKMKEQEKECELEKER 593

Query: 287 MKLPEHPEGGEP 298
            KL E  E  EP
Sbjct: 594 EKLEEKIEPREP 605



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 41/192 (21%), Positives = 90/192 (46%), Gaps = 15/192 (7%)

Query: 172 SKVKDAVEQQGEVKKNKRERKEERQK-----KRKREKKELKLENHQENSRNQKPKKRKKG 226
           S++  AVE+  + ++ +  R EE++K     K KR  ++L +   Q +    + ++R+K 
Sbjct: 453 SEISAAVERARKRREEEERRMEEQRKAACAEKLKRLDEKLGILEKQPSPEEIREREREKE 512

Query: 227 QEADLEAGGEEVPEANGSAGK-RSKKKKQRKDSASEEEARVGAGKRKRRHSEVETDSKKK 285
           +E + E   E+  E      K R +++++ K+   E+E +    K +++  E E + +K+
Sbjct: 513 REREKELEKEQEQEREKEREKDRERQQEKEKELEKEQEKQREMEKERKQEKEKELERQKE 572

Query: 286 K----MKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITIKKLRKKVLAQYY 341
           K     K+ E  +  E E +    + K   +      + +  ++E +  K  + V  +  
Sbjct: 573 KEKELQKMKEQEKECELEKEREKLEEKIEPREPNLEPMVEKQESENSCNKEEEPVFTR-- 630

Query: 342 TVTDEHHRSEEE 353
               + +RSE+E
Sbjct: 631 ---QDSNRSEKE 639



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 35/130 (26%), Positives = 62/130 (47%), Gaps = 16/130 (12%)

Query: 165 ISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRK--------REKKELKLENHQENSR 216
           I  K P+ +     E++ E ++ K   KE+ Q++ K        +++KE +LE  QE  R
Sbjct: 494 ILEKQPSPEEIREREREKEREREKELEKEQEQEREKEREKDRERQQEKEKELEKEQEKQR 553

Query: 217 NQKPKKRKKGQEADLEAGGEEVPEANGSAGKRSKKKKQRKDSASEEEARVGAGKRKRRHS 276
             + K+RK+ +E +LE   E+  E         K K+Q K+   E+E      K + R  
Sbjct: 554 EME-KERKQEKEKELERQKEKEKEL-------QKMKEQEKECELEKEREKLEEKIEPREP 605

Query: 277 EVETDSKKKK 286
            +E   +K++
Sbjct: 606 NLEPMVEKQE 615



 Score = 37.7 bits (86), Expect = 0.017
 Identities = 53/255 (20%), Positives = 101/255 (39%), Gaps = 46/255 (18%)

Query: 126  NESILDQVWNIFSEASNSEPVN--KEQDQRPLHPVANPHAEISTKVPASKVKDAVEQQGE 183
            N++  DQ    +  AS S   N  +E+D++        +A+++ +      ++ +  + E
Sbjct: 1485 NQNSSDQANEEWETASESSDFNERRERDEKK-------NADLNAQTVVKVGENVLPPKRE 1537

Query: 184  VKKNK--RERKEERQKKRKREKKELKLENHQ--ENSRNQKP--KKRKKGQEADLEAGGEE 237
            + K     +R  +RQ +R          N     N R   P  K  K+G   D  AG   
Sbjct: 1538 IAKRSFSSQRPVDRQNRRGNNGPPKSGRNFSGPRNERRSGPPSKSGKRGPFDDQPAGTTG 1597

Query: 238  VPEANGSAGKRSKK------KKQRKDSASEEEARVGAGKRKRRH-----SEVETDSKKKK 286
            V   NGS+    +       +K  KDS  ++      G +K +      S+ + ++    
Sbjct: 1598 VDLINGSSAHHQEGVPNGTGQKNSKDSTGKKREDPKPGPKKPKEKVDALSQFDLNNYASV 1657

Query: 287  MKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITIKKLRKKVLAQYYTVTDE 346
            + + +HPE    ED ++               L      E+  KK +K++        +E
Sbjct: 1658 VIIDDHPEVTVIEDPQSN--------------LNDDGFTEVVSKKQQKRLQ------DEE 1697

Query: 347  HHRSEEELLVIFNKK 361
              + EE+++ ++NKK
Sbjct: 1698 RRKKEEQVIQVWNKK 1712



 Score = 36.2 bits (82), Expect = 0.050
 Identities = 32/141 (22%), Positives = 66/141 (46%), Gaps = 9/141 (6%)

Query: 175 KDAVEQQGEVKKNKRERKEE------RQKKRKREKKELKLENHQENSRNQKPKK-RKKGQ 227
           K  V  + E+ K +R ++ E      R +KR RE++E ++E  ++ +  +K K+  +K  
Sbjct: 435 KQQVADEDEIWKQRRRQQSEISAAVERARKR-REEEERRMEEQRKAACAEKLKRLDEKLG 493

Query: 228 EADLEAGGEEVPEANGSAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETDSKKKKM 287
             + +   EE+ E      +R ++K+  K+   E E      + +++  E E + +++K 
Sbjct: 494 ILEKQPSPEEIREREREK-EREREKELEKEQEQEREKEREKDRERQQEKEKELEKEQEKQ 552

Query: 288 KLPEHPEGGEPEDDEAPAKGK 308
           +  E     E E +    K K
Sbjct: 553 REMEKERKQEKEKELERQKEK 573



 Score = 35.8 bits (81), Expect = 0.065
 Identities = 43/200 (21%), Positives = 83/200 (41%), Gaps = 21/200 (10%)

Query: 130 LDQVWNIFSEASNSEPVNKEQDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKR 189
           LD+   I  +  + E + + + ++          E   +    + KD   QQ    + ++
Sbjct: 488 LDEKLGILEKQPSPEEIREREREKEREREKELEKEQEQEREKEREKDRERQQ----EKEK 543

Query: 190 ERKEERQKKRKREK-----KELKLENHQENSRN-QKPKKRKKGQEADLEAGGEEVPEANG 243
           E ++E++K+R+ EK     KE +LE  +E  +  QK K+++K  E +LE   E++ E   
Sbjct: 544 ELEKEQEKQREMEKERKQEKEKELERQKEKEKELQKMKEQEK--ECELEKEREKLEE--- 598

Query: 244 SAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEA 303
              K   ++   +    ++E+     K +      +  ++ +K   P   E  EPE    
Sbjct: 599 ---KIEPREPNLEPMVEKQESENSCNKEEEPVFTRQDSNRSEKEATPVVHE-TEPESGSQ 654

Query: 304 PAKGKFNWKGTIKAILKQAP 323
           P     +  G  K   K  P
Sbjct: 655 PRPAVLS--GYFKQFQKSLP 672



 Score = 31.2 bits (69), Expect = 1.6
 Identities = 40/174 (22%), Positives = 66/174 (37%), Gaps = 31/174 (17%)

Query: 138  SEASNSEPVNKEQDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQK 197
            SE+S+ E V K + QR         +E  T    S++ ++   +  + K K  ++EER +
Sbjct: 1246 SESSDFEVVPKRRRQRG--------SETDTD---SEIHESASDKDSLSKGKLPKREERPE 1294

Query: 198  KRKREK--KELKLENHQ--ENSRNQKPKKRKKGQ-EADLEAGGEEVPEANGSAGKRSKKK 252
             +K  K     K +NH   +N   +KP  R   + +      GE      G   +R  + 
Sbjct: 1295 NKKPVKPHSSFKPDNHVRIDNRLLEKPYVRDDDKAKPGFLPKGEPTRRGRGGTFRRGGRD 1354

Query: 253  KQRKDSASEEEARVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAK 306
                            G R  R S +   + +     P   E  +PED E P +
Sbjct: 1355 P---------------GGRPSRPSTLRRPAYRDNQWNPRQSEVPKPEDGEPPRR 1393


>gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain
           containing B [Homo sapiens]
          Length = 546

 Score = 52.0 bits (123), Expect = 9e-07
 Identities = 32/121 (26%), Positives = 59/121 (48%), Gaps = 2/121 (1%)

Query: 175 KDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQK--PKKRKKGQEADLE 232
           K+   ++ + ++  RER +E++ + + E+K+ K +      R+ K   KK KK   +   
Sbjct: 372 KERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSR 431

Query: 233 AGGEEVPEANGSAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETDSKKKKMKLPEH 292
                    + +AGKRS+ + + K S  + E++  + KR R  S+  TDS +K  K    
Sbjct: 432 ERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHS 491

Query: 293 P 293
           P
Sbjct: 492 P 492



 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 36/142 (25%), Positives = 66/142 (46%), Gaps = 14/142 (9%)

Query: 175 KDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAG 234
           KD    + + + +K+E+K  R + R+R+ +       +  SRN   + R + +E   +  
Sbjct: 407 KDDRRHRDDKRDSKKEKKHSRSRSRERKHRS------RSRSRNAGKRSRSRSKEKSSKHK 460

Query: 235 GEEVPEAN-----GSAGKRS--KKKKQRKDSASEEEARVGAGKRKRRHSEVETDSKKKKM 287
            E   ++N     GS G+    +K K+R+ S S+E++R  +  ++R H    +DSK +  
Sbjct: 461 NESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSD 520

Query: 288 KLP-EHPEGGEPEDDEAPAKGK 308
           K      +  E E  E   K K
Sbjct: 521 KHDRRRSQSIEQESQEKQHKNK 542



 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 31/102 (30%), Positives = 52/102 (50%), Gaps = 9/102 (8%)

Query: 185 KKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVPEANGS 244
           +  +R R   R + RK ++++   E  +EN R      R++ ++ D E G E   E   S
Sbjct: 331 RSRERHRSRSRSRDRKGDRRDRDREREKENERG-----RRRDRDYDKERGNEREKERERS 385

Query: 245 AGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETDSKKKK 286
             +RSK+++ R +    EE +    K  RRH + + DSKK+K
Sbjct: 386 R-ERSKEQRSRGEV---EEKKHKEDKDDRRHRDDKRDSKKEK 423



 Score = 38.5 bits (88), Expect = 0.010
 Identities = 24/97 (24%), Positives = 47/97 (48%), Gaps = 8/97 (8%)

Query: 190 ERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVPEANGSAGKRS 249
           +R+ ER+K+R+R ++E K          +K ++R +  +  LE       E + S  +  
Sbjct: 292 DRELEREKERQRLEREAK--------EREKERRRSRSIDRGLERRRSRSRERHRSRSRSR 343

Query: 250 KKKKQRKDSASEEEARVGAGKRKRRHSEVETDSKKKK 286
            +K  R+D   E E     G+R+ R  + E  ++++K
Sbjct: 344 DRKGDRRDRDREREKENERGRRRDRDYDKERGNEREK 380



 Score = 37.4 bits (85), Expect = 0.022
 Identities = 27/110 (24%), Positives = 50/110 (45%), Gaps = 8/110 (7%)

Query: 197 KKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVPEANGSAGKRSKKKKQRK 256
           ++ +REK+  +LE  +E    +K ++R +  +  LE       E + S  +   +K  R+
Sbjct: 293 RELEREKERQRLE--REAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRR 350

Query: 257 DSASEEEARVGAGKR------KRRHSEVETDSKKKKMKLPEHPEGGEPED 300
           D   E E     G+R      K R +E E + ++ + +  E    GE E+
Sbjct: 351 DRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEE 400


>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 668

 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 49/222 (22%), Positives = 99/222 (44%), Gaps = 15/222 (6%)

Query: 79  QKISELIKRPNVSPKVRELLEQISAFDNVPRKKAKFQNWMKNSLKVHNESILDQVWNIFS 138
           +KI E  KR       R+  E+I   + + R+K K    M    K+  +   ++VW    
Sbjct: 450 EKIREEEKRQEQEEMWRQE-EKIREQEEIWRQKEK----MHEQEKIRKQE--EKVWRQEE 502

Query: 139 EASNSEPVNKEQDQRPLHPVAN-PHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQK 197
           +  + E   +EQ+++           E   +    K+++  E   E ++   E++E+ Q+
Sbjct: 503 KMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQE 562

Query: 198 KRKREKKELKLENHQENSRNQKPKKRKKG-----QEADLEAGGEEVPEANGSAGKRSKKK 252
           + K  ++E K+   +E  R QK K R++      QE  +    E + E      ++ +K 
Sbjct: 563 QEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKM 622

Query: 253 KQRKDSASEEEARVGAGKRKRRHSEVETDSKKKKMKLPEHPE 294
            ++++   E+E ++   + K    EV    +++KM+  EH E
Sbjct: 623 CEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQ--EHQE 662



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 44/230 (19%), Positives = 96/230 (41%), Gaps = 16/230 (6%)

Query: 64  EGKTHKGDIKQQAWIQKISELIKRPNVSPKVRELLEQISAFDNVPRKKAKFQNWMKNSLK 123
           E K  + + K Q W +KI E         K+RE  E+I   +   R++ +   W K    
Sbjct: 299 EEKMWRQEEKIQEWEEKIQEQ------EEKIREQEEKIREQEEKMRRQEEMM-WEKEEKM 351

Query: 124 VHNESILDQVWNIFSEASNSEPVNKEQDQRPLHPVANPHAEISTKVPASKVKDAVEQQGE 183
              E ++   W    +    E +  E++++        H +   +    K ++  + + +
Sbjct: 352 RRQEEMM---WEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQ 408

Query: 184 VKKNKRERKEERQKKRKRE------KKELKLENHQENSRNQKPKKRKKGQEADLEAGGEE 237
            K+ ++E K  RQ+++ RE      ++E K+   +E    Q+  + ++ ++   E   +E
Sbjct: 409 EKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQE 468

Query: 238 VPEANGSAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETDSKKKKM 287
                     R K+K   ++   ++E +V   + K    E +   +++KM
Sbjct: 469 EKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKM 518



 Score = 39.7 bits (91), Expect = 0.005
 Identities = 33/199 (16%), Positives = 88/199 (44%), Gaps = 12/199 (6%)

Query: 93  KVRELLEQISAFDNVPRKKAKFQNWMKNSLKVHNESILDQVWNIFSEASNSEPVNKEQDQ 152
           K+REL E++   + +  ++ K Q   K   +   +    ++W    +    E   +EQ++
Sbjct: 378 KIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEK 437

Query: 153 RPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQ 212
           +        H +        K+++      E ++ + E   + +K R++E+   + E   
Sbjct: 438 KMWRQEEKIHEQ-------EKIREE-----EKRQEQEEMWRQEEKIREQEEIWRQKEKMH 485

Query: 213 ENSRNQKPKKRKKGQEADLEAGGEEVPEANGSAGKRSKKKKQRKDSASEEEARVGAGKRK 272
           E  + +K +++   QE  +    E++ E      ++ +K +++++   E+E ++   +  
Sbjct: 486 EQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEM 545

Query: 273 RRHSEVETDSKKKKMKLPE 291
            +  E +   +++KM+  E
Sbjct: 546 MQEQEEKMGEQEEKMQEQE 564



 Score = 37.7 bits (86), Expect = 0.017
 Identities = 42/208 (20%), Positives = 91/208 (43%), Gaps = 5/208 (2%)

Query: 83  ELIKRPNVSPKVRELLEQISAFDNVPRKKAKFQNWMKNSLKVHNESILDQVWNIFSEASN 142
           +LI R + S K    LEQ  A   V  +K K   +++   K  +   L+   N  ++   
Sbjct: 162 DLISRLHDSWKFAGELEQ--ALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEEL 219

Query: 143 SEPVNKEQDQRPLHPVANPHAEISTKVPASKVKDA--VEQQGEVKKNKRERKEERQKKRK 200
            E   K Q++  L        +++ K    K++ A  +  Q +++       +E Q    
Sbjct: 220 KEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSA 279

Query: 201 REKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVPEANGSAGKRSKKKKQRKDSAS 260
           + + +++ EN   N  NQ+ +++   QE  ++   E++ E      ++ +K +++++   
Sbjct: 280 KLQAQVE-ENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMR 338

Query: 261 EEEARVGAGKRKRRHSEVETDSKKKKMK 288
            +E  +   + K R  E     K++KM+
Sbjct: 339 RQEEMMWEKEEKMRRQEEMMWEKEEKMR 366



 Score = 34.3 bits (77), Expect = 0.19
 Identities = 32/170 (18%), Positives = 75/170 (44%), Gaps = 17/170 (10%)

Query: 185 KKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVPEANGS 244
           K+ K  R EE   +++ + +EL+ + H++    ++ +KR   QE +     E+  E    
Sbjct: 361 KEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKR---QEEEKIREQEKRQEQEAK 417

Query: 245 AGKRSKKKKQRKDSASEEEARVGAGKRKRRHSE-VETDSKKKKMKLPEHPEGGEPEDDEA 303
             ++ +K +++++   E+E ++   + K    E +  + K+++ +     E    E +E 
Sbjct: 418 MWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEI 477

Query: 304 PAKGKFNWKGTIKAILKQAPDNEITIKKLRKKVLAQYYTVTDEHHRSEEE 353
                  W+       K+    +  I+K  +KV  Q   + D+  +  E+
Sbjct: 478 -------WR------QKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQ 514



 Score = 32.7 bits (73), Expect = 0.55
 Identities = 27/171 (15%), Positives = 75/171 (43%), Gaps = 5/171 (2%)

Query: 183 EVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEVPEAN 242
           E+   K E+  E ++K   ++K  + E  ++     + +++++ QEA +    E++ E  
Sbjct: 370 EMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQE 429

Query: 243 GSAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDE 302
               ++ KK  ++++   E+E      KR+ +      + K ++ +     +    E ++
Sbjct: 430 EKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEK 489

Query: 303 APAKGKFNWKGTIKAILKQAPDNEITIKKLRKKVLAQYYTVTDEHHRSEEE 353
              + +  W+       ++  D E  I++  +K+  Q   + ++  +  E+
Sbjct: 490 IRKQEEKVWRQE-----EKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQ 535


>gi|34878777 ring finger protein 20 [Homo sapiens]
          Length = 975

 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 70/325 (21%), Positives = 140/325 (43%), Gaps = 50/325 (15%)

Query: 84  LIKRPNVSPKVRELLEQISAFDN--------VPRKKAKFQNWMK--NSLKVHNESILDQV 133
           L       P  RE+   IS+  N        V R K K +      N  ++ + S L Q 
Sbjct: 463 LAANEQAGPINREMRHLISSLQNHNHQLKGEVLRYKRKLREAQSDLNKTRLRSGSALLQS 522

Query: 134 WNIFSEASNSEPVNKEQDQRPLHP---VANPHAEISTKVPASKVKDAVEQQGEVKKNKRE 190
            +  +E    EP   + D   L      +    E + ++ + + ++  E++   K+ +RE
Sbjct: 523 QSS-TEDPKDEPAELKPDSEDLSSQSSASKASQEDANEIKSKRDEEERERERREKERERE 581

Query: 191 RKEERQKKRKREKKELKLENHQENSRNQKPK-KRKKGQEADLEAGGE---EVPEANGSAG 246
           R+ E++K+R+REK++LK    + +S   K K K   G++ + E   +   E+ +A  S  
Sbjct: 582 REREKEKEREREKQKLKESEKERDSAKDKEKGKHDDGRKKEAEIIKQLKIELKKAQESQK 641

Query: 247 K--------RSKKKKQRKD---SASEEEARVGAGKRKRRHSEVETDSKKKKMKLPEHPEG 295
           +        RS  K+QR      A+E++++      ++R  ++E   KK+  K+      
Sbjct: 642 EMKLLLDMYRSAPKEQRDKVQLMAAEKKSKAELEDLRQRLKDLEDKEKKENKKM------ 695

Query: 296 GEPEDDEAPAKGKFNWKGTIKAILKQAP--DNEITIKKLRKKVLAQYYTVTDE--HHRSE 351
               D++A  K        I+A+ +Q      ++ + K  ++ L     VT +      E
Sbjct: 696 ---ADEDALRK--------IRAVEEQIEYLQKKLAMAKQEEEALLSEMDVTGQAFEDMQE 744

Query: 352 EELLVIFNKKISKNPTFKLLKDKVK 376
           + + ++   +   +  FKL+ +++K
Sbjct: 745 QNIRLMQQLREKDDANFKLMSERIK 769


>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
          Length = 1020

 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 60/236 (25%), Positives = 105/236 (44%), Gaps = 26/236 (11%)

Query: 85  IKRPNVSPKVRELLEQISAFDNVPRK-KAKFQNWMKNSLKVHNESILDQVWNIFSEASNS 143
           +K P      +E  E  S  D  P K K+  +  +K+  K  +    D      ++A   
Sbjct: 761 VKSPEAKTPAKE--EARSPADKFPEKAKSPVKEEVKSPEKAKSPLKED------AKAPEK 812

Query: 144 EPVNKEQDQRPLHPVANPHAEISTKVPASKVKD----AVEQQGEVKKNKRER--KEERQK 197
           E   KE+ + P+     P  E+  K P  K ++    A  +  E K +K+E   K+E  K
Sbjct: 813 EIPKKEEVKSPVKEEEKPQ-EVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPK 871

Query: 198 KRKREKKELKLENHQEN---SRNQKPKKRKKGQEADLEAGGE-EVPEANGSAGKRSKKKK 253
            +  EKKE  +E  +E+   ++ ++ + +KK    + EA  + EV E      K    KK
Sbjct: 872 PKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKK 931

Query: 254 QRKDSASEEEARVGAGKRKRRHSEVETDSKKKKMKLPEH---PEGGEPEDDEAPAK 306
           +  D+ ++E ++      K+  +  + D+K++K K PE     E    EDD+  +K
Sbjct: 932 EPDDAKAKEPSKPA---EKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSK 984



 Score = 48.1 bits (113), Expect = 1e-05
 Identities = 49/228 (21%), Positives = 103/228 (45%), Gaps = 23/228 (10%)

Query: 168 KVPASKVKDAVEQQGEVKKNKRERKE----ERQKKRKREKKELKLENHQENSRNQKPKKR 223
           K+P+      V+ + ++K  ++  KE    E Q +  +  +E+  E  +E ++ ++ K+ 
Sbjct: 428 KIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKE-AKEEEGKEE 486

Query: 224 KKGQEADLEAGGEEV---PEANGSAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVET 280
           + G+E + E G EE    P    ++ ++  K   ++++ S  EA+    +  +  +EV++
Sbjct: 487 EGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKS 546

Query: 281 DSKKK-----------KMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILK-QAPDNEIT 328
             K K           + K PE  E   P + ++P K K   K   K+  + ++P+   +
Sbjct: 547 PEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKS 606

Query: 329 IKKLRKKVLAQYYTVTDEHHRSEEELLVIFNKKISKNPTFKLLKDKVK 376
             K   K  A+  +   E  +S  E   + + + +K+PT +  K   K
Sbjct: 607 PVKEEAKSPAEAKSPVKEEAKSPAE---VKSPEKAKSPTKEEAKSPEK 651



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 56/234 (23%), Positives = 84/234 (35%), Gaps = 20/234 (8%)

Query: 138 SEASNSEPVNKEQDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERK---EE 194
           S A    PV KE+ + P    +   A+  TK  A   + A   + E  K+  + K   + 
Sbjct: 614 SPAEAKSPV-KEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKA 672

Query: 195 RQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAGGEEV--PEANGSAGKRSKKK 252
             K  ++ K  +K E           K+  K  E       EE   PE   S  K   K 
Sbjct: 673 EAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKT 732

Query: 253 KQRKDSASEEEARVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDD----------- 301
            ++  S  +EEA+    K K        D K  + K P   E   P D            
Sbjct: 733 PEKAKSPVKEEAK-SPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKE 791

Query: 302 --EAPAKGKFNWKGTIKAILKQAPDNEITIKKLRKKVLAQYYTVTDEHHRSEEE 353
             ++P K K   K   KA  K+ P  E     ++++   Q   V +   ++EEE
Sbjct: 792 EVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEE 845



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 50/229 (21%), Positives = 86/229 (37%), Gaps = 10/229 (4%)

Query: 81   ISELIKRPNVSPKVRELLEQISAFDNVPRKKAKFQNWMKNSLKVHNESILDQVWNIFSEA 140
            + E +K P  +     L E   A +    KK + ++ +K   K     + +       E 
Sbjct: 789  VKEEVKSPEKAKS--PLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEK 846

Query: 141  SNSEPVNKEQDQRPLHPVANPHAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRK 200
            + + P  K ++++       P  E        K + AVE+  E K     +KEE + K+K
Sbjct: 847  APATP--KTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESK--VEAKKEEAEDKKK 902

Query: 201  REKKELKLENHQENSRNQKPKKR---KKGQEADLEAGGEEVPEANGSAGKRSKKKKQRKD 257
                E +     E   + KPK++    K +  D +A     P     A    K  K+ K 
Sbjct: 903  VPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKA 962

Query: 258  SASEEEARVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAPAK 306
               EE+ +  A K K     +  +  K K +  E     + +D + P K
Sbjct: 963  KKPEEKPKTEA-KAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEK 1010



 Score = 39.7 bits (91), Expect = 0.005
 Identities = 67/289 (23%), Positives = 110/289 (38%), Gaps = 31/289 (10%)

Query: 69  KGDIKQQAWI-QKISELIKRPNVSPKVRELLEQISAFDNVPRKKAKFQNWMKNSLKVHNE 127
           K  +K++A   +K    +K    SP+  +  E+    D V   +AK         K    
Sbjct: 723 KSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLD-VKSPEAK------TPAKEEAR 775

Query: 128 SILDQVWNIFSEASNSEPVNKEQDQRPLHPVAN-PHAEISTKVPASKVKDAVEQQGEVKK 186
           S  D+           E  + E+ + PL   A  P  EI  K          E+  EVK 
Sbjct: 776 SPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKV 835

Query: 187 NKRERKEERQKKRKREKKELKLENHQENSRNQ---KPKKRKKGQEADLEAGGEEVPEANG 243
            +  +K E +K     K E K ++ +E +  +   KPK  +K + A       E P+ + 
Sbjct: 836 KEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPA------VEKPKESK 889

Query: 244 SAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEA 303
              K+ + + ++K    E+EA            EV+ D+K K     E  E  + E D+A
Sbjct: 890 VEAKKEEAEDKKKVPTPEKEAPAKV--------EVKEDAKPK-----EKTEVAKKEPDDA 936

Query: 304 PAKGKFNWKGTIKAILKQAPDNEITIKKLRKKVLAQYYTVTDEHHRSEE 352
            AK         +A  ++    E   KK  +K   +     D+   S+E
Sbjct: 937 KAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKE 985



 Score = 38.5 bits (88), Expect = 0.010
 Identities = 56/281 (19%), Positives = 109/281 (38%), Gaps = 19/281 (6%)

Query: 52  ISEDQKYGGKGYEGKTHKGDIKQQAWIQKISELIKRPNVSPKVRELLEQISAFDNVPRKK 111
           ++E+++   K  EGK  +G  +++A  +   E  K P          E  S      +  
Sbjct: 470 VTEEEEKEAKEEEGKEEEGGEEEEA--EGGEEETKSPPAEEAASPEKEAKSPVKEEAKSP 527

Query: 112 AKFQNWMKNSLKVHNE-SILDQVWNIFSEASNSEPVNKEQDQRPLHPVANPHAEISTKVP 170
           A+ ++  K   K   E    ++  +   E + S P  K  ++      A   +    K P
Sbjct: 528 AEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSP 587

Query: 171 ASKVKDAVEQQGEVKKNKRERKEERQ---------KKRKREKKELKLENHQENSRNQKPK 221
           A +   +  +    +K K   KEE +         K+  +   E+K     ++   ++ K
Sbjct: 588 AKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAK 647

Query: 222 KRKKGQEADLEAGGEEVPEANGSAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETD 281
             +K +  + E    + PE   S  K   K  ++  S  + EA+      ++  S V+ +
Sbjct: 648 SPEKAKSPEKEEA--KSPEKAKSPVKAEAKSPEKAKSPVKAEAK----SPEKAKSPVKEE 701

Query: 282 SKK-KKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQ 321
           +K  +K K P   E   PE  ++P K +       K+ +K+
Sbjct: 702 AKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKE 742



 Score = 31.2 bits (69), Expect = 1.6
 Identities = 26/126 (20%), Positives = 54/126 (42%), Gaps = 2/126 (1%)

Query: 163  AEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKK 222
            AE   KVP  + K+A  +  EVK++ + +++    K++ +  + K  +     +   P+K
Sbjct: 897  AEDKKKVPTPE-KEAPAKV-EVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEK 954

Query: 223  RKKGQEADLEAGGEEVPEANGSAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETDS 282
            +   +E   +   +   EA      ++  K+  K  A + E      ++  +  E  T+ 
Sbjct: 955  KDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATED 1014

Query: 283  KKKKMK 288
            K  K K
Sbjct: 1015 KAAKGK 1020


>gi|116089325 splicing factor, arginine/serine-rich 12 isoform a
           [Homo sapiens]
          Length = 624

 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 31/119 (26%), Positives = 56/119 (47%), Gaps = 19/119 (15%)

Query: 175 KDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAG 234
           ++ ++++  VK+  RE++ ER+K+R++EK        +      + K+R+K +E D E  
Sbjct: 381 REKIKEKERVKEKDREKEREREKEREKEK--------ERGKNKDRDKEREKDREKDKEKD 432

Query: 235 GEEVPEANGSAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETDSKKKKMKLPEHP 293
            E           R ++K+  KD   E+E      K + +    E D K+KK K    P
Sbjct: 433 RE-----------REREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTP 480



 Score = 48.9 bits (115), Expect = 7e-06
 Identities = 36/174 (20%), Positives = 79/174 (45%), Gaps = 10/174 (5%)

Query: 162 HAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPK 221
           H+    K    K+K+    + + ++ +RER++ER+K+++R K + + +  +++    K K
Sbjct: 372 HSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEK 431

Query: 222 KRKKGQEADLEAGGEEVPEANGSAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETD 281
            R++ +E + E   ++  E      ++ K+K++ KD + E + +    K+ R        
Sbjct: 432 DREREREKEHEKDRDKEKEK-----EQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNA 486

Query: 282 SKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITIKKLRKK 335
           S++ +    E           +P   K     TIK    ++P      KK +K+
Sbjct: 487 SRRSRSSSRERRRRRSRSSSRSPRTSK-----TIKRKSSRSPSPRSRNKKDKKR 535



 Score = 46.6 bits (109), Expect = 4e-05
 Identities = 46/208 (22%), Positives = 86/208 (41%), Gaps = 8/208 (3%)

Query: 172 SKVKDAVEQQGEVKKNK---RERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQE 228
           SK + + +     K+++   R R   R + R+++++  K  + + +   ++ K R +   
Sbjct: 314 SKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHS 373

Query: 229 ADLEAG-GEEVPEANGSAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETDSKKKKM 287
            D      E++ E      K  +K+++R+    +E+ R   GK K R  E E D +K K 
Sbjct: 374 RDKRKDTREKIKEKERVKEKDREKEREREKEREKEKER---GKNKDRDKEREKDREKDKE 430

Query: 288 KLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITIKKLRKKVLAQYYTVTDEH 347
           K  E     E E D    K K   K   +   +    +E   K  + +   + Y  +   
Sbjct: 431 KDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRS 490

Query: 348 HRSEEELLVIFNKKISKNP-TFKLLKDK 374
             S  E     ++  S++P T K +K K
Sbjct: 491 RSSSRERRRRRSRSSSRSPRTSKTIKRK 518



 Score = 42.7 bits (99), Expect = 5e-04
 Identities = 41/149 (27%), Positives = 61/149 (40%), Gaps = 8/149 (5%)

Query: 162 HAEISTKVPASKVKDAVEQQGEVKKNK--RERKEERQKKRKREKKELKLENHQENSRNQK 219
           H   S     S+ KD    +   KK    RER++ R +   R+K++   E  +E  R  K
Sbjct: 333 HRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKER-VK 391

Query: 220 PKKRKKGQEADLEAGGEEVPEANGSAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVE 279
            K R+K +E + E   E+    N    K  ++K + KD   + E        K R  E E
Sbjct: 392 EKDREKEREREKEREKEKERGKNKDRDKE-REKDREKDKEKDREREREKEHEKDRDKEKE 450

Query: 280 TDSKKKKMKLPEHPEGGEPEDDEAPAKGK 308
            +  K+K    E  +    E DE   K K
Sbjct: 451 KEQDKEK----EREKDRSKEIDEKRKKDK 475



 Score = 37.4 bits (85), Expect = 0.022
 Identities = 28/147 (19%), Positives = 58/147 (39%), Gaps = 5/147 (3%)

Query: 165 ISTKVPASKVKDAVEQQGEVKKNKRERKEERQK---KRKREKKELKLENHQENSRNQKPK 221
           IS  +     K    + G  + + R +     K   +RKR + + +  +H  +   QK +
Sbjct: 289 ISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDR 348

Query: 222 KRKKGQEADLEAGGEEVPEANGSAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETD 281
           +R K          E     + S  +   K+K  ++   E+E      + K R  E E +
Sbjct: 349 RRSKSPHKKRSKSRERRKSRSRSHSR--DKRKDTREKIKEKERVKEKDREKEREREKERE 406

Query: 282 SKKKKMKLPEHPEGGEPEDDEAPAKGK 308
            +K++ K  +  +  E + ++   K +
Sbjct: 407 KEKERGKNKDRDKEREKDREKDKEKDR 433



 Score = 32.7 bits (73), Expect = 0.55
 Identities = 22/80 (27%), Positives = 36/80 (45%), Gaps = 1/80 (1%)

Query: 185 KKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLE-AGGEEVPEANG 243
           ++ +R R   R  +  +  K     +    SRN+K KKR+K ++   E    E       
Sbjct: 497 RRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRK 556

Query: 244 SAGKRSKKKKQRKDSASEEE 263
           S+  R  K+K  K+S S +E
Sbjct: 557 SSNDRDGKEKLEKNSTSLKE 576



 Score = 30.8 bits (68), Expect = 2.1
 Identities = 30/134 (22%), Positives = 57/134 (42%), Gaps = 19/134 (14%)

Query: 185 KKNKRERKEERQK------KRKREKKEL---KLENHQENSRNQKPKKRKKGQEADLEAGG 235
           K+  +E++ E+ +      KRK++KK     +  N    SR+   ++R++   +   +  
Sbjct: 451 KEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPR 510

Query: 236 EEVPEANGSAGKRSKKKKQRKDSASEEEARVGAGKRKR------RHSEVETDSKKKKMK- 288
                   S+   S + + +KD   E+E    + +R+R      R S  + D K+K  K 
Sbjct: 511 TSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKN 570

Query: 289 ---LPEHPEGGEPE 299
              L E     EP+
Sbjct: 571 STSLKEKEHNKEPD 584


>gi|21040255 splicing factor, arginine/serine-rich 12 isoform b
           [Homo sapiens]
          Length = 508

 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 31/119 (26%), Positives = 56/119 (47%), Gaps = 19/119 (15%)

Query: 175 KDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLEAG 234
           ++ ++++  VK+  RE++ ER+K+R++EK        +      + K+R+K +E D E  
Sbjct: 265 REKIKEKERVKEKDREKEREREKEREKEK--------ERGKNKDRDKEREKDREKDKEKD 316

Query: 235 GEEVPEANGSAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETDSKKKKMKLPEHP 293
            E           R ++K+  KD   E+E      K + +    E D K+KK K    P
Sbjct: 317 RE-----------REREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTP 364



 Score = 48.9 bits (115), Expect = 7e-06
 Identities = 36/174 (20%), Positives = 79/174 (45%), Gaps = 10/174 (5%)

Query: 162 HAEISTKVPASKVKDAVEQQGEVKKNKRERKEERQKKRKREKKELKLENHQENSRNQKPK 221
           H+    K    K+K+    + + ++ +RER++ER+K+++R K + + +  +++    K K
Sbjct: 256 HSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEK 315

Query: 222 KRKKGQEADLEAGGEEVPEANGSAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETD 281
            R++ +E + E   ++  E      ++ K+K++ KD + E + +    K+ R        
Sbjct: 316 DREREREKEHEKDRDKEKEK-----EQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNA 370

Query: 282 SKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITIKKLRKK 335
           S++ +    E           +P   K     TIK    ++P      KK +K+
Sbjct: 371 SRRSRSSSRERRRRRSRSSSRSPRTSK-----TIKRKSSRSPSPRSRNKKDKKR 419



 Score = 46.6 bits (109), Expect = 4e-05
 Identities = 46/208 (22%), Positives = 86/208 (41%), Gaps = 8/208 (3%)

Query: 172 SKVKDAVEQQGEVKKNK---RERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQE 228
           SK + + +     K+++   R R   R + R+++++  K  + + +   ++ K R +   
Sbjct: 198 SKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHS 257

Query: 229 ADLEAG-GEEVPEANGSAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETDSKKKKM 287
            D      E++ E      K  +K+++R+    +E+ R   GK K R  E E D +K K 
Sbjct: 258 RDKRKDTREKIKEKERVKEKDREKEREREKEREKEKER---GKNKDRDKEREKDREKDKE 314

Query: 288 KLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITIKKLRKKVLAQYYTVTDEH 347
           K  E     E E D    K K   K   +   +    +E   K  + +   + Y  +   
Sbjct: 315 KDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRS 374

Query: 348 HRSEEELLVIFNKKISKNP-TFKLLKDK 374
             S  E     ++  S++P T K +K K
Sbjct: 375 RSSSRERRRRRSRSSSRSPRTSKTIKRK 402



 Score = 42.7 bits (99), Expect = 5e-04
 Identities = 41/149 (27%), Positives = 61/149 (40%), Gaps = 8/149 (5%)

Query: 162 HAEISTKVPASKVKDAVEQQGEVKKNK--RERKEERQKKRKREKKELKLENHQENSRNQK 219
           H   S     S+ KD    +   KK    RER++ R +   R+K++   E  +E  R  K
Sbjct: 217 HRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKER-VK 275

Query: 220 PKKRKKGQEADLEAGGEEVPEANGSAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVE 279
            K R+K +E + E   E+    N    K  ++K + KD   + E        K R  E E
Sbjct: 276 EKDREKEREREKEREKEKERGKNKDRDKE-REKDREKDKEKDREREREKEHEKDRDKEKE 334

Query: 280 TDSKKKKMKLPEHPEGGEPEDDEAPAKGK 308
            +  K+K    E  +    E DE   K K
Sbjct: 335 KEQDKEK----EREKDRSKEIDEKRKKDK 359



 Score = 37.4 bits (85), Expect = 0.022
 Identities = 28/147 (19%), Positives = 58/147 (39%), Gaps = 5/147 (3%)

Query: 165 ISTKVPASKVKDAVEQQGEVKKNKRERKEERQK---KRKREKKELKLENHQENSRNQKPK 221
           IS  +     K    + G  + + R +     K   +RKR + + +  +H  +   QK +
Sbjct: 173 ISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDR 232

Query: 222 KRKKGQEADLEAGGEEVPEANGSAGKRSKKKKQRKDSASEEEARVGAGKRKRRHSEVETD 281
           +R K          E     + S  +   K+K  ++   E+E      + K R  E E +
Sbjct: 233 RRSKSPHKKRSKSRERRKSRSRSHSR--DKRKDTREKIKEKERVKEKDREKEREREKERE 290

Query: 282 SKKKKMKLPEHPEGGEPEDDEAPAKGK 308
            +K++ K  +  +  E + ++   K +
Sbjct: 291 KEKERGKNKDRDKEREKDREKDKEKDR 317



 Score = 32.7 bits (73), Expect = 0.55
 Identities = 22/80 (27%), Positives = 36/80 (45%), Gaps = 1/80 (1%)

Query: 185 KKNKRERKEERQKKRKREKKELKLENHQENSRNQKPKKRKKGQEADLE-AGGEEVPEANG 243
           ++ +R R   R  +  +  K     +    SRN+K KKR+K ++   E    E       
Sbjct: 381 RRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRK 440

Query: 244 SAGKRSKKKKQRKDSASEEE 263
           S+  R  K+K  K+S S +E
Sbjct: 441 SSNDRDGKEKLEKNSTSLKE 460



 Score = 30.8 bits (68), Expect = 2.1
 Identities = 30/134 (22%), Positives = 57/134 (42%), Gaps = 19/134 (14%)

Query: 185 KKNKRERKEERQK------KRKREKKEL---KLENHQENSRNQKPKKRKKGQEADLEAGG 235
           K+  +E++ E+ +      KRK++KK     +  N    SR+   ++R++   +   +  
Sbjct: 335 KEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPR 394

Query: 236 EEVPEANGSAGKRSKKKKQRKDSASEEEARVGAGKRKR------RHSEVETDSKKKKMK- 288
                   S+   S + + +KD   E+E    + +R+R      R S  + D K+K  K 
Sbjct: 395 TSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKN 454

Query: 289 ---LPEHPEGGEPE 299
              L E     EP+
Sbjct: 455 STSLKEKEHNKEPD 468


>gi|48255931 hepatoma-derived growth factor-related protein 2
           isoform 1 [Homo sapiens]
          Length = 671

 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 44/175 (25%), Positives = 78/175 (44%), Gaps = 14/175 (8%)

Query: 176 DAVEQQGEVKKNKRERKEERQKKRKRE-KKELKLENHQENSRNQKPKKRKKGQEADLEAG 234
           D V++  E K+    R+ E + +R+RE ++EL+    QE    ++ ++R    EA+  +G
Sbjct: 308 DEVDRISEWKRRDEARRRELEARRRREQEEELRRLREQEKEEKERRRERADRGEAERGSG 367

Query: 235 ---GEEVPEANGSAGKRSKKKKQR-----KDSASEEEARVGAGKRKRRHSEVETD----- 281
              G+E+ E +    KR +K + R      DS  E E    A K  ++     T+     
Sbjct: 368 GSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEPEAELEREAKKSAKKPQSSSTEPARKP 427

Query: 282 SKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITIKKLRKKV 336
            +K+K   PE  +  +P   E   K    +    K   K+ P  E  ++KL  ++
Sbjct: 428 GQKEKRVRPEEKQQAKPVKVERTRKRSEGFSMDRKVEKKKEPSVEEKLQKLHSEI 482



 Score = 32.7 bits (73), Expect = 0.55
 Identities = 49/230 (21%), Positives = 78/230 (33%), Gaps = 31/230 (13%)

Query: 105 DNVPRKKAKFQNWMKNSLKVHNESILDQVWNIFSEASNSEPVNKEQDQRP-LHPVANPHA 163
           D  P  K K +    N  K  NE + +   N  +  S   PV+    + P  +P     A
Sbjct: 57  DLFPYDKCKDKYGKPNKRKGFNEGLWEIQNNPHASYSAPPPVSSSDSEAPEANPADGSDA 116

Query: 164 EIS---------TKVPASKVKDAVEQQGEVKKN------KRERKEERQKKRKREKKELK- 207
           +           T V A+   D +E   +  K+      KR+    +    KR +K    
Sbjct: 117 DEDDEDRGVMAVTAVTATAASDRMESDSDSDKSSDNSGLKRKTPALKMSVSKRARKASSD 176

Query: 208 ------LENHQENSRNQKPKKRKKGQEADLEAGGEEVPEANGSAGKRSKKKKQRKDSASE 261
                   + +ENS +    ++   Q+   E          G  G R KKKK    S S+
Sbjct: 177 LDQASVSPSEEENSESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGR-KKKKAPSASDSD 235

Query: 262 EEARVGAGK-------RKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAP 304
            +A     K       R    S   + S    + + + P G +P +   P
Sbjct: 236 SKADSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLP 285


>gi|14249158 hepatoma-derived growth factor-related protein 2
           isoform 2 [Homo sapiens]
          Length = 670

 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 44/175 (25%), Positives = 78/175 (44%), Gaps = 14/175 (8%)

Query: 176 DAVEQQGEVKKNKRERKEERQKKRKRE-KKELKLENHQENSRNQKPKKRKKGQEADLEAG 234
           D V++  E K+    R+ E + +R+RE ++EL+    QE    ++ ++R    EA+  +G
Sbjct: 308 DEVDRISEWKRRDEARRRELEARRRREQEEELRRLREQEKEEKERRRERADRGEAERGSG 367

Query: 235 ---GEEVPEANGSAGKRSKKKKQR-----KDSASEEEARVGAGKRKRRHSEVETD----- 281
              G+E+ E +    KR +K + R      DS  E E    A K  ++     T+     
Sbjct: 368 GSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEPEAELEREAKKSAKKPQSSSTEPARKP 427

Query: 282 SKKKKMKLPEHPEGGEPEDDEAPAKGKFNWKGTIKAILKQAPDNEITIKKLRKKV 336
            +K+K   PE  +  +P   E   K    +    K   K+ P  E  ++KL  ++
Sbjct: 428 GQKEKRVRPEEKQQAKPVKVERTRKRSEGFSMDRKVEKKKEPSVEEKLQKLHSEI 482



 Score = 32.7 bits (73), Expect = 0.55
 Identities = 49/230 (21%), Positives = 78/230 (33%), Gaps = 31/230 (13%)

Query: 105 DNVPRKKAKFQNWMKNSLKVHNESILDQVWNIFSEASNSEPVNKEQDQRP-LHPVANPHA 163
           D  P  K K +    N  K  NE + +   N  +  S   PV+    + P  +P     A
Sbjct: 57  DLFPYDKCKDKYGKPNKRKGFNEGLWEIQNNPHASYSAPPPVSSSDSEAPEANPADGSDA 116

Query: 164 EIS---------TKVPASKVKDAVEQQGEVKKN------KRERKEERQKKRKREKKELK- 207
           +           T V A+   D +E   +  K+      KR+    +    KR +K    
Sbjct: 117 DEDDEDRGVMAVTAVTATAASDRMESDSDSDKSSDNSGLKRKTPALKMSVSKRARKASSD 176

Query: 208 ------LENHQENSRNQKPKKRKKGQEADLEAGGEEVPEANGSAGKRSKKKKQRKDSASE 261
                   + +ENS +    ++   Q+   E          G  G R KKKK    S S+
Sbjct: 177 LDQASVSPSEEENSESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGR-KKKKAPSASDSD 235

Query: 262 EEARVGAGK-------RKRRHSEVETDSKKKKMKLPEHPEGGEPEDDEAP 304
            +A     K       R    S   + S    + + + P G +P +   P
Sbjct: 236 SKADSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLP 285


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.309    0.128    0.365 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,990,791
Number of Sequences: 37866
Number of extensions: 839111
Number of successful extensions: 17722
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 577
Number of HSP's successfully gapped in prelim test: 844
Number of HSP's that attempted gapping in prelim test: 6366
Number of HSP's gapped (non-prelim): 6028
length of query: 379
length of database: 18,247,518
effective HSP length: 104
effective length of query: 275
effective length of database: 14,309,454
effective search space: 3935099850
effective search space used: 3935099850
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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