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Search of human proteins with 8923224
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|8923224 leucine rich repeat (in FLII) interacting protein 2
isoform 2 [Homo sapiens]
(400 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|8923224 leucine rich repeat (in FLII) interacting protein 2 i... 764 0.0
gi|197276647 leucine rich repeat (in FLII) interacting protein 2... 751 0.0
gi|5453726 leucine rich repeat (in FLII) interacting protein 2 i... 541 e-154
gi|212276088 leucine rich repeat (in FLII) interacting protein 1... 422 e-118
gi|212276078 leucine rich repeat (in FLII) interacting protein 1... 322 5e-88
gi|212276104 leucine rich repeat (in FLII) interacting protein 1... 231 9e-61
gi|212276070 leucine rich repeat (in FLII) interacting protein 1... 214 8e-56
gi|212276096 leucine rich repeat (in FLII) interacting protein 1... 202 4e-52
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 74 2e-13
gi|31982906 cingulin-like 1 [Homo sapiens] 66 5e-11
gi|38044112 restin isoform b [Homo sapiens] 64 2e-10
gi|4506751 restin isoform a [Homo sapiens] 64 2e-10
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 63 4e-10
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 62 7e-10
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 62 1e-09
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 61 2e-09
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 61 2e-09
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 60 3e-09
gi|239745085 PREDICTED: similar to Golgin subfamily A member 8-l... 59 6e-09
gi|239745081 PREDICTED: similar to Golgin subfamily A member 8-l... 59 6e-09
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 59 6e-09
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 59 8e-09
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 58 1e-08
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 58 2e-08
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 58 2e-08
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 58 2e-08
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 58 2e-08
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 58 2e-08
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 58 2e-08
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 58 2e-08
>gi|8923224 leucine rich repeat (in FLII) interacting protein 2
isoform 2 [Homo sapiens]
Length = 400
Score = 764 bits (1974), Expect = 0.0
Identities = 400/400 (100%), Positives = 400/400 (100%)
Query: 1 MGTPASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKEL 60
MGTPASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKEL
Sbjct: 1 MGTPASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKEL 60
Query: 61 DEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSEVE 120
DEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSEVE
Sbjct: 61 DEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSEVE 120
Query: 121 EKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCS 180
EKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCS
Sbjct: 121 EKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCS 180
Query: 181 VLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESA 240
VLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESA
Sbjct: 181 VLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESA 240
Query: 241 GEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIE 300
GEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIE
Sbjct: 241 GEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIE 300
Query: 301 MQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRK 360
MQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRK
Sbjct: 301 MQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRK 360
Query: 361 LQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ 400
LQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ
Sbjct: 361 LQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ 400
>gi|197276647 leucine rich repeat (in FLII) interacting protein 2
isoform 3 [Homo sapiens]
Length = 424
Score = 751 bits (1939), Expect = 0.0
Identities = 400/424 (94%), Positives = 400/424 (94%), Gaps = 24/424 (5%)
Query: 1 MGTPASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKEL 60
MGTPASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKEL
Sbjct: 1 MGTPASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKEL 60
Query: 61 DEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELR------- 113
DEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELR
Sbjct: 61 DEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKD 120
Query: 114 -----------------ESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEE 156
ESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEE
Sbjct: 121 QIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEE 180
Query: 157 QMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGD 216
QMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGD
Sbjct: 181 QMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGD 240
Query: 217 VSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQK 276
VSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQK
Sbjct: 241 VSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQK 300
Query: 277 CSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQ 336
CSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQ
Sbjct: 301 CSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQ 360
Query: 337 VLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTAL 396
VLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTAL
Sbjct: 361 VLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTAL 420
Query: 397 LAQQ 400
LAQQ
Sbjct: 421 LAQQ 424
>gi|5453726 leucine rich repeat (in FLII) interacting protein 2
isoform 1 [Homo sapiens]
Length = 721
Score = 541 bits (1395), Expect = e-154
Identities = 314/447 (70%), Positives = 330/447 (73%), Gaps = 93/447 (20%)
Query: 43 AEARDIRMRELERQQKELDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSL 102
+E DI + +L LDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSL
Sbjct: 279 SEVDDISIPDLS----SLDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSL 334
Query: 103 IDPDTSLSELR------------------------ESLSEVEEKYKKAMVSNAQLDNEKN 138
IDPDTSLSELR ESLSEVEEKYKKAMVSNAQLDNEKN
Sbjct: 335 IDPDTSLSELRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEKYKKAMVSNAQLDNEKN 394
Query: 139 NLIYQVDTLKDVIEEQE-------------------------------EQMAEFYRENEE 167
NLIYQVDTLKDVIEEQE E++ E R+ +E
Sbjct: 395 NLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDE 454
Query: 168 KSKE-------------------------------LERQKHMCSVLQHKMEELKEGLRQR 196
+E LE+QK + L+++ + L+E L
Sbjct: 455 LIEEKQRMQQKIDTMTKEVFDLQETLLWKDKKIGALEKQKEYIACLRNERDMLREELADL 514
Query: 197 DELI---EKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLA 253
E + EKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLA
Sbjct: 515 QETVKTGEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLA 574
Query: 254 GEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYK 313
GEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYK
Sbjct: 575 GEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYK 634
Query: 314 FKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIE 373
FKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIE
Sbjct: 635 FKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIE 694
Query: 374 EMEMTNSHLAKRLEKMKANRTALLAQQ 400
EMEMTNSHLAKRLEKMKANRTALLAQQ
Sbjct: 695 EMEMTNSHLAKRLEKMKANRTALLAQQ 721
Score = 114 bits (286), Expect = 1e-25
Identities = 77/145 (53%), Positives = 88/145 (60%), Gaps = 12/145 (8%)
Query: 1 MGTPASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKE- 59
MGTPASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKE
Sbjct: 1 MGTPASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKEY 60
Query: 60 ----LDEK--SDKQYAENYTRPSSRNSASATTPLSG-----NSSRRGSGDTSSLIDPDTS 108
D K +++ E+ R + +S P G + GS D +
Sbjct: 61 SLHSFDRKWGQIQKWLEDSERARYSHRSSHHRPYLGVEDALSIRSVGSHRYDMFKDRSSR 120
Query: 109 LSELRESLSEVEEKYKKAMVSNAQL 133
LS L S S K++ S+ L
Sbjct: 121 LSSLNHSYSHSHGMKKRSSDSHKDL 145
>gi|212276088 leucine rich repeat (in FLII) interacting protein 1
isoform 2 [Homo sapiens]
Length = 394
Score = 422 bits (1084), Expect = e-118
Identities = 228/387 (58%), Positives = 297/387 (76%), Gaps = 5/387 (1%)
Query: 18 SAEDEALSNIARE-AEARLAAKRAARAEARDIRMRELERQQKELDEKSDKQYAENYTRPS 76
S E + LS A++ AEARLAAKRAARAEAR+IRM+ELERQQKE++E+ +K + E +R
Sbjct: 9 SREIDCLSPEAQKLAEARLAAKRAARAEAREIRMKELERQQKEVEERPEKDFTEKGSRNM 68
Query: 77 SRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSEVEEKYKKAMVSNAQLDNE 136
SA+ L G SSRRGSGDTS ID + S+ E+++SL+EVEEKYKKAMVSNAQLDNE
Sbjct: 69 PGLSAATLASLGGTSSRRGSGDTSISIDTEASIREIKDSLAEVEEKYKKAMVSNAQLDNE 128
Query: 137 KNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQR 196
K N +YQVDTLKD++ E EEQ+AE R+ EEK+KE ER+KH S+LQ + E+KE L+QR
Sbjct: 129 KTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQR 188
Query: 197 DELIEKHGLVIIPDGTPNGDVS---HEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLA 253
+E++EKHG+++ + NG+ S + T +++E L+S G+G LD+RL+KL
Sbjct: 189 EEMLEKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLKKLV 248
Query: 254 GEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYK 313
E+E LL QI+KLK QL EERQK + D + L+NG+D+ +++QRDANRQIS+ K
Sbjct: 249 DERECLLEQIKKLKGQL-EERQKIGKLDNLRSEDDVLENGTDMHVMDLQRDANRQISDLK 307
Query: 314 FKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIE 373
FKL+K+EQ+IT LEQ++ RLE QV RYK+AAENAEK+EDELKAEKRKLQRELR+ALDK E
Sbjct: 308 FKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSALDKTE 367
Query: 374 EMEMTNSHLAKRLEKMKANRTALLAQQ 400
E+E++N HL KRLEKMKANR+ALL+QQ
Sbjct: 368 ELEVSNGHLVKRLEKMKANRSALLSQQ 394
>gi|212276078 leucine rich repeat (in FLII) interacting protein 1
isoform 1 [Homo sapiens]
Length = 640
Score = 322 bits (824), Expect = 5e-88
Identities = 198/435 (45%), Positives = 261/435 (60%), Gaps = 90/435 (20%)
Query: 55 RQQKELDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRE 114
R ++E+ +K + E +R SA+ L G SSRRGSGDTS ID + S+ E++E
Sbjct: 207 RASPVVEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGSGDTSISIDTEASIREIKE 266
Query: 115 ------------------------SLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDV 150
SL+EVEEKYKKAMVSNAQLDNEK N +YQVDTLKD+
Sbjct: 267 LNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLKDM 326
Query: 151 IEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKM----------EELKEGLRQ----- 195
+ E EEQ+AE R+ EEK+KE ER+KH S+LQ + EE+ E +RQ
Sbjct: 327 LLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEEIRQLQQKQ 386
Query: 196 -------------------------------------RDEL----------IEKHGLVII 208
RD+L ++KHG+++
Sbjct: 387 ASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEVVMLKEELKKHGIILN 446
Query: 209 PDGTPNGDVS---HEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRK 265
+ NG+ S + T +++E L+S G+G LD+RL+KL E+E LL QI+K
Sbjct: 447 SEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLKKLVDERECLLEQIKK 506
Query: 266 LKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITT 325
LK QLEE RQK + D + L+NG+D+ +++QRDANRQIS+ KFKL+K+EQ+IT
Sbjct: 507 LKGQLEE-RQKIGKLDNLRSEDDVLENGTDMHVMDLQRDANRQISDLKFKLAKSEQEITA 565
Query: 326 LEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKR 385
LEQ++ RLE QV RYK+AAENAEK+EDELKAEKRKLQRELR+ALDK EE+E++N HL KR
Sbjct: 566 LEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSALDKTEELEVSNGHLVKR 625
Query: 386 LEKMKANRTALLAQQ 400
LEKMKANR+ALL+QQ
Sbjct: 626 LEKMKANRSALLSQQ 640
Score = 99.4 bits (246), Expect = 5e-21
Identities = 57/111 (51%), Positives = 73/111 (65%), Gaps = 15/111 (13%)
Query: 1 MGTPASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKEL 60
MGT SGRKR P ++R +AED+AL+ IAREAEARLAAKRAARAEAR+IRM+ELERQQKE+
Sbjct: 3 MGTQGSGRKRLPNRERLTAEDDALNQIAREAEARLAAKRAARAEAREIRMKELERQQKEI 62
Query: 61 DEKSDKQY---------------AENYTRPSSRNSASATTPLSGNSSRRGS 96
+ K Y +E Y+R S RN++++ + RGS
Sbjct: 63 YQVQKKYYGLDTKWGDIEQWMEDSERYSRRSRRNTSASDEDERMSVGSRGS 113
>gi|212276104 leucine rich repeat (in FLII) interacting protein 1
isoform 5 [Homo sapiens]
Length = 752
Score = 231 bits (589), Expect = 9e-61
Identities = 145/338 (42%), Positives = 215/338 (63%), Gaps = 17/338 (5%)
Query: 18 SAEDEALSNIARE-AEARLAAKRAARAEARDIRMRELERQQKELDEKSDKQYAENYTRPS 76
S E + LS A++ AEARLAAKRAARAEAR+IRM+ELERQQKE++E+ +K + E +R
Sbjct: 9 SREIDCLSPEAQKLAEARLAAKRAARAEAREIRMKELERQQKEVEERPEKDFTEKGSRNM 68
Query: 77 SRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSEVEEKYKKAMVSNAQLDNE 136
SA+ L G SSRRGSGDTS ID + S+ E+++SL+EVEEKYKKAMVSNAQLDNE
Sbjct: 69 PGLSAATLASLGGTSSRRGSGDTSISIDTEASIREIKDSLAEVEEKYKKAMVSNAQLDNE 128
Query: 137 KNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQR 196
K N +YQVDTLKD++ E EEQ+AE R+ EEK+KE ER+KH S+LQ + E+KE L+QR
Sbjct: 129 KTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQR 188
Query: 197 DELIEKHGLVIIPDGTPNGDVS---HEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLA 253
+E++EKHG+++ + NG+ S + T +++E L+S G+G L R ++
Sbjct: 189 EEMLEKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLG-RASEVE 247
Query: 254 GEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYK 313
K E+++ + K ++ E+++ + TV D ++ + E Q+ ++ + +
Sbjct: 248 -VKNEIVANVGKREILHNTEKEQ--HTEDTVKDCVDIEVFPAGENTEDQK-SSEDTAPFL 303
Query: 314 FKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVE 351
L+ A T E+ + + Q+L + EN +VE
Sbjct: 304 GTLAGA-----TYEEQV---QSQILESSSLPENTVQVE 333
Score = 32.3 bits (72), Expect = 0.78
Identities = 42/183 (22%), Positives = 69/183 (37%), Gaps = 24/183 (13%)
Query: 61 DEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELR-ESLSEV 119
DEK K + N AT P + ++ + + +PD S+ + E+L
Sbjct: 454 DEKPIKTEVPGSPAGTEGNCQEATGPSTVDTQN----EPLDMKEPDEEKSDQQGEALDSS 509
Query: 120 EEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMC 179
++K K N + N+K V+TLKDV +E Q + EE+
Sbjct: 510 QKKTK-----NKKKKNKKKKSPVPVETLKDVKKELTYQNTDLSEIKEEE----------- 553
Query: 180 SVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLES 239
Q K + K + ++E+ E I + + N D P + QE V +
Sbjct: 554 ---QVKSTDRKSAVEAQNEVTENPKQKIAAESSENVDCPENPKIKLDGKLDQEGDDVQTA 610
Query: 240 AGE 242
A E
Sbjct: 611 AEE 613
>gi|212276070 leucine rich repeat (in FLII) interacting protein 1
isoform 4 [Homo sapiens]
Length = 784
Score = 214 bits (546), Expect = 8e-56
Identities = 146/370 (39%), Positives = 214/370 (57%), Gaps = 49/370 (13%)
Query: 18 SAEDEALSNIARE-AEARLAAKRAARAEARDIRMRELERQQKELD--------------- 61
S E + LS A++ AEARLAAKRAARAEAR+IRM+ELERQQKE D
Sbjct: 9 SREIDCLSPEAQKLAEARLAAKRAARAEAREIRMKELERQQKEEDSERYSRRSRRNTSAS 68
Query: 62 -----------------EKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLID 104
E+ +K + E +R SA+ L G SSRRGSGDTS ID
Sbjct: 69 DEDERMSVGSRGSLRVEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGSGDTSISID 128
Query: 105 PDTSLSELRESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRE 164
+ S+ E+++SL+EVEEKYKKAMVSNAQLDNEK N +YQVDTLKD++ E EEQ+AE R+
Sbjct: 129 TEASIREIKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLKDMLLELEEQLAESRRQ 188
Query: 165 NEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVS---HEP 221
EEK+KE ER+KH S+LQ + E+KE L+QR+E++EKHG+++ + NG+ S +
Sbjct: 189 YEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEKHGIILNSEIATNGETSDTLNNV 248
Query: 222 VAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRND 281
T +++E L+S G+G L R ++ K E+++ + K ++ E+++ +
Sbjct: 249 GYQGPTKMTKEELNALKSTGDGTLG-RASEVE-VKNEIVANVGKREILHNTEKEQ--HTE 304
Query: 282 GTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYK 341
TV D ++ + E Q+ ++ + + L+ A T E+ + + Q+L
Sbjct: 305 DTVKDCVDIEVFPAGENTEDQK-SSEDTAPFLGTLAGA-----TYEEQV---QSQILESS 355
Query: 342 TAAENAEKVE 351
+ EN +VE
Sbjct: 356 SLPENTVQVE 365
Score = 32.3 bits (72), Expect = 0.78
Identities = 42/183 (22%), Positives = 69/183 (37%), Gaps = 24/183 (13%)
Query: 61 DEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELR-ESLSEV 119
DEK K + N AT P + ++ + + +PD S+ + E+L
Sbjct: 486 DEKPIKTEVPGSPAGTEGNCQEATGPSTVDTQN----EPLDMKEPDEEKSDQQGEALDSS 541
Query: 120 EEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMC 179
++K K N + N+K V+TLKDV +E Q + EE+
Sbjct: 542 QKKTK-----NKKKKNKKKKSPVPVETLKDVKKELTYQNTDLSEIKEEE----------- 585
Query: 180 SVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLES 239
Q K + K + ++E+ E I + + N D P + QE V +
Sbjct: 586 ---QVKSTDRKSAVEAQNEVTENPKQKIAAESSENVDCPENPKIKLDGKLDQEGDDVQTA 642
Query: 240 AGE 242
A E
Sbjct: 643 AEE 645
>gi|212276096 leucine rich repeat (in FLII) interacting protein 1
isoform 3 [Homo sapiens]
Length = 808
Score = 202 bits (514), Expect = 4e-52
Identities = 147/394 (37%), Positives = 214/394 (54%), Gaps = 73/394 (18%)
Query: 18 SAEDEALSNIARE-AEARLAAKRAARAEARDIRMRELERQQKELD--------------- 61
S E + LS A++ AEARLAAKRAARAEAR+IRM+ELERQQKE D
Sbjct: 9 SREIDCLSPEAQKLAEARLAAKRAARAEAREIRMKELERQQKEEDSERYSRRSRRNTSAS 68
Query: 62 -----------------EKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLID 104
E+ +K + E +R SA+ L G SSRRGSGDTS ID
Sbjct: 69 DEDERMSVGSRGSLRVEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGSGDTSISID 128
Query: 105 PDTSLSELRE------------------------SLSEVEEKYKKAMVSNAQLDNEKNNL 140
+ S+ E++E SL+EVEEKYKKAMVSNAQLDNEK N
Sbjct: 129 TEASIREIKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNF 188
Query: 141 IYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELI 200
+YQVDTLKD++ E EEQ+AE R+ EEK+KE ER+KH S+LQ + E+KE L+QR+E++
Sbjct: 189 MYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEML 248
Query: 201 EKHGLVIIPDGTPNGDVS---HEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKE 257
EKHG+++ + NG+ S + T +++E L+S G+G L R ++ K
Sbjct: 249 EKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLG-RASEVE-VKN 306
Query: 258 ELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLS 317
E+++ + K ++ E+++ + TV D ++ + E Q+ ++ + + L+
Sbjct: 307 EIVANVGKREILHNTEKEQ--HTEDTVKDCVDIEVFPAGENTEDQK-SSEDTAPFLGTLA 363
Query: 318 KAEQDITTLEQSISRLEGQVLRYKTAAENAEKVE 351
A T E+ + + Q+L + EN +VE
Sbjct: 364 GA-----TYEEQV---QSQILESSSLPENTVQVE 389
Score = 32.3 bits (72), Expect = 0.78
Identities = 42/183 (22%), Positives = 69/183 (37%), Gaps = 24/183 (13%)
Query: 61 DEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELR-ESLSEV 119
DEK K + N AT P + ++ + + +PD S+ + E+L
Sbjct: 510 DEKPIKTEVPGSPAGTEGNCQEATGPSTVDTQN----EPLDMKEPDEEKSDQQGEALDSS 565
Query: 120 EEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMC 179
++K K N + N+K V+TLKDV +E Q + EE+
Sbjct: 566 QKKTK-----NKKKKNKKKKSPVPVETLKDVKKELTYQNTDLSEIKEEE----------- 609
Query: 180 SVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLES 239
Q K + K + ++E+ E I + + N D P + QE V +
Sbjct: 610 ---QVKSTDRKSAVEAQNEVTENPKQKIAAESSENVDCPENPKIKLDGKLDQEGDDVQTA 666
Query: 240 AGE 242
A E
Sbjct: 667 AEE 669
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 74.3 bits (181), Expect = 2e-13
Identities = 79/401 (19%), Positives = 183/401 (45%), Gaps = 46/401 (11%)
Query: 14 KDRFSAEDEALS-----NIAREAEARLAAKRAARAEARDIRMRELERQQKELDEKSDKQY 68
KD S E + L N++++A K + + + + + +E D S
Sbjct: 1749 KDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLS---- 1804
Query: 69 AENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSE---LRESLSEVEEKYKK 125
S+R + S + P + +++ S D SS + + L + L+E ++ +EE+ +K
Sbjct: 1805 ------MSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQK 1858
Query: 126 AMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHK 185
+ L+NEKN L+ Q+ T ++ +E++ + N++ +EL R + + +
Sbjct: 1859 NKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEE 1918
Query: 186 MEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPL 245
++L+E R ++L E +G + G DV+ + + + E + + E L
Sbjct: 1919 KDDLEE--RLMNQLAELNGSI----GNYCQDVTDAQIKNEL--LESEMKNLKKCVSE--L 1968
Query: 246 DVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDA 305
+ ++L EK ++ S+IRK L+ + QK N +L L + ++Q+D
Sbjct: 1969 EEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDC 2028
Query: 306 ----------NRQISEYKFKLSKAEQDITTLEQSIS-------RLEGQVLRYKTAAENAE 348
R + +F +++++D+ +++++ + + ++ +K ++ +
Sbjct: 2029 IRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQ 2088
Query: 349 KVEDELKAEKRKLQRELRTALDKIE-EMEMTNSHLAKRLEK 388
+ A+ KL++EL++ + ++ +M+ + L +RLE+
Sbjct: 2089 SEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQ 2129
Score = 53.1 bits (126), Expect = 4e-07
Identities = 73/406 (17%), Positives = 166/406 (40%), Gaps = 36/406 (8%)
Query: 22 EALSNIAREAEARLAAKRAARAEARDIRMRELERQQKELDEKSDKQYAENYTRPSSRNSA 81
E L+ + E++++A+ + R+ L+ ++ +L + D+ EN + SS S
Sbjct: 1514 ERLTKSLADVESQVSAQNKEKDTVLG-RLALLQEERDKLITEMDRSLLENQSLSSSCESL 1572
Query: 82 SATTPLSGNSSRRGSGDTSSLIDPDTSLS-ELRESLSEVEEKYKKAMVSNAQLDNEKNNL 140
+ + SL + S E +E E++++Y+ + S + NE +
Sbjct: 1573 KLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERI 1632
Query: 141 IYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELI 200
+ V+ ++ +E ++ +E K+L+ + ++ KM + + +Q+ +
Sbjct: 1633 QHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILEL 1692
Query: 201 EKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLE----SAGEGPLDVRLRKLAGEK 256
E+ + + P GD + E + T++S A+ E L + + L EK
Sbjct: 1693 EEENDRLRAEVHPAGDTAKECME---TLLSSNASMKEELERVKMEYETLSKKFQSLMSEK 1749
Query: 257 EELLSQIRKLKLQLE--------------EERQKCSRNDGTVGDLAGLQNGSDL------ 296
+ L +++ LK Q+E + Q +GT + L
Sbjct: 1750 DSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRP 1809
Query: 297 ---QFIEMQRDANRQISE---YKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKV 350
+ + + AN +S+ +++ Q I L++ I+ LE + + K ++ E
Sbjct: 1810 TCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENE 1869
Query: 351 EDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKM-KANRTA 395
++ L ++ EL+ +++ +M + N + + L ++ K TA
Sbjct: 1870 KNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETA 1915
Score = 52.4 bits (124), Expect = 7e-07
Identities = 74/381 (19%), Positives = 148/381 (38%), Gaps = 39/381 (10%)
Query: 42 RAEARDIRMRELERQQKELDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSS 101
R + DI+ + +Q E D ++ ++ + + LSG
Sbjct: 2343 RQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAEL 2402
Query: 102 LIDPDTSLSELRESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEF 161
D + EL LS+ EE+ N + ++ N L+ + T+K +Q+ Q+ F
Sbjct: 2403 RQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSF 2462
Query: 162 YRENEEKSKELER---------QKHMCSVLQHKMEELKEGLRQRDELIEK-HGLVIIPDG 211
+ + +R ++H+ S++ K + ++E + ++L E+ GL D
Sbjct: 2463 VKSMSSLQNDRDRIVGDYQQLEERHL-SIILEKDQLIQEAAAENNKLKEEIRGLRSHMDD 2521
Query: 212 TPNGDVS--------HEPVAGAITVVSQEAAQVLESAGEGPLDV-----RLRKLAGEKEE 258
+ + E + IT+ + Q+LE + ++ +L + E EE
Sbjct: 2522 LNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEE 2581
Query: 259 LLSQIRKLKLQLEEERQKCSRN--------DGTVGDLAGLQNGSDLQFIEMQ-RDANRQI 309
+R+ L+EE+Q S+ + LQ L Q + ++
Sbjct: 2582 ANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEV 2641
Query: 310 SEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTAL 369
S +++ I LE+ + V K AA+ ++ED+LK E + L +
Sbjct: 2642 HRLSALFSSSQKRIAELEEEL------VCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMR 2695
Query: 370 DKIEEMEMTNSHLAKRLEKMK 390
++ E E + LA+ L +M+
Sbjct: 2696 NETETAEERVAELARDLVEME 2716
Score = 49.7 bits (117), Expect = 5e-06
Identities = 78/365 (21%), Positives = 152/365 (41%), Gaps = 52/365 (14%)
Query: 43 AEARDIRMRELERQQKELDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSL 102
A+++D+++ L Q ELD+ Q++E T S S L S G +
Sbjct: 805 AKSKDVKIEVL---QNELDDVQ-LQFSEQSTLIRSLQSQ-----LQNKESEVLEG-AERV 854
Query: 103 IDPDTSLSELRESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFY 162
+ + EL ++LS+ E + K QL EK V+TL+ IEE+++Q+ E
Sbjct: 855 RHISSKVEELSQALSQKELEITKM----DQLLLEKKR---DVETLQQTIEEKDQQVTEIS 907
Query: 163 RENEEKSKELERQKHMCSV----------LQHKMEELKEGLRQRDELIEKHGLVIIPDGT 212
EK +L +K V L + EE K+ + D + + +
Sbjct: 908 FSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMS 967
Query: 213 PNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAG---EKEELLSQIRKLKLQ 269
P G +S E + ++ +E Q R RKL ++ELL ++ +L+ +
Sbjct: 968 PAGQISKEELQHEFDLLKKENEQ------------RKRKLQAALINRKELLQRVSRLEEE 1015
Query: 270 LEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQS 329
L + + + L+ + G E++ D + K SK ++ L+Q+
Sbjct: 1016 LANLKDESKKEI----PLSETERG------EVEEDKENKEYSEKCVTSKCQEIEIYLKQT 1065
Query: 330 ISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKM 389
IS E ++ + E E++ +A +++ + L+ ++I+ ++ S ++K+
Sbjct: 1066 ISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKL 1125
Query: 390 KANRT 394
+ T
Sbjct: 1126 ITSNT 1130
Score = 48.9 bits (115), Expect = 8e-06
Identities = 79/387 (20%), Positives = 162/387 (41%), Gaps = 35/387 (9%)
Query: 3 TPASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAA--RAEARDIRMRELERQQKEL 60
T +S + ++++ A ++ + ++ + L +++A +A+ ++ +RE +QQK+
Sbjct: 1152 TGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDD 1211
Query: 61 DEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSEVE 120
+ +Q+ E + + S G ++ + +S L E L +
Sbjct: 1212 YNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKAT 1271
Query: 121 EKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELE-RQKHMC 179
E++ V + L + + L+ Q+ +E E + ELE +
Sbjct: 1272 EQHHTQPVLESNLCPDWPSHSEDASALQG--GTSVAQIKAQLKEIEAEKVELELKVSSTT 1329
Query: 180 SVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLES 239
S L K EE+ Q E I K GL I T VSHE A ++ + + L+
Sbjct: 1330 SELTKKSEEVF----QLQEQINKQGLEIESLKT----VSHEAEVHAESLQQKLESSQLQI 1381
Query: 240 AGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFI 299
AG L +R+L+ +L+E ++ S+ + V L+G + +
Sbjct: 1382 AG------------------LEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALT 1423
Query: 300 EMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKR 359
++Q + Q K ++ E ++ I +L+ ++ K + E++ +E +A K+
Sbjct: 1424 KIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMK---QKPEEIGEESRA-KQ 1479
Query: 360 KLQRELRTALDKIEEMEMTNSHLAKRL 386
++QR+L+ AL +E N L + L
Sbjct: 1480 QIQRKLQAALISRKEALKENKSLQEEL 1506
Score = 48.1 bits (113), Expect = 1e-05
Identities = 76/413 (18%), Positives = 168/413 (40%), Gaps = 46/413 (11%)
Query: 21 DEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKELDEKSDKQYAENYT----RPS 76
D + N E+E + K + E ++L +++ +++ + K+Y E P
Sbjct: 1946 DAQIKNELLESEMKNLKKCVSELEEEK---QQLVKEKTKVESEIRKEYLEKIQGAQKEPG 2002
Query: 77 SRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSEVEEKYKKAMVSNAQLDNE 136
+++ A L + I +S L ++ +E + S L+
Sbjct: 2003 NKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTE---SQKDLEIT 2059
Query: 137 KNNLIYQVD----------TLKDVIEEQEEQMAEFYRENEEKSKELERQKHMC-SVLQHK 185
K NL V+ + K ++++ + + A +N + KEL+ K S ++ K
Sbjct: 2060 KENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQK 2119
Query: 186 MEELKEGLRQRDE--LIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEG 243
E+L+ L Q +E L EK + D V E G I V + + ++ E
Sbjct: 2120 DEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQEN 2179
Query: 244 PLDVRLRKLAG----------EKEELLSQIRKLK------LQLEEERQKCSRNDGTVGDL 287
LD + +LA +++ ++ + +K + +Q +EE + ++ +V L
Sbjct: 2180 -LDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSV--L 2236
Query: 288 AGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENA 347
+ E++ + +R + + SKA+ ++ ++ L+G+ + E
Sbjct: 2237 KDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEET 2296
Query: 348 EKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ 400
+ + E KL+ EL++ D++ ++ S+ ++ ++ K N ++ QQ
Sbjct: 2297 RHLYHSSQNELAKLESELKSLKDQLTDL----SNSLEKCKEQKGNLEGIIRQQ 2345
Score = 47.4 bits (111), Expect = 2e-05
Identities = 77/399 (19%), Positives = 163/399 (40%), Gaps = 30/399 (7%)
Query: 10 RTPVKDRFSAE-DEALSNIARE-AEARLAAKRAARAEARDI-RMRELERQQKELDEKSDK 66
R P+ E D +N +E + RLA E +DI R ++++ QQK+ + ++
Sbjct: 27 RAPLDPELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEER 86
Query: 67 QYAENYTRPSSRNSASATTPLSGN-SSRRGSGDTSSLIDPDTSLSELRESLSEVEEKYKK 125
+ A+N + ++ + T L+ + G T +P + + S EE+ +
Sbjct: 87 KAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEI 146
Query: 126 AMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEE---KSKELERQKHMCSVL 182
+ + EK LI + + + Q EQ A+ E EE ++L+ ++ S L
Sbjct: 147 EKIKHKL--QEKEELISTLQA--QLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTL 202
Query: 183 QHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGE 242
Q ++ + + + + EK ++ + Q+ +VL+
Sbjct: 203 QAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQ---- 258
Query: 243 GPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGL--QNGSDLQFIE 300
RKL +E L+ + + + L +E RN L + ++ + +E
Sbjct: 259 -------RKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVE 311
Query: 301 MQRDANRQISEYKFKLSKAEQDIT--TLEQSISRLEGQVLRYKTAAENAEKVEDELKAEK 358
+R+ ++ + E K +L AE+ ++ L++ + L Q ++ A + ++E A +
Sbjct: 312 TEREESKILLE-KMELEVAERKLSFHNLQEEMHHLLEQ---FEQAGQAQAELESRYSALE 367
Query: 359 RKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALL 397
+K + E+ I ++ T L + +K + LL
Sbjct: 368 QKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLL 406
Score = 45.4 bits (106), Expect = 9e-05
Identities = 70/296 (23%), Positives = 130/296 (43%), Gaps = 28/296 (9%)
Query: 109 LSELRESLSEVEE--KYKKAMVSN--AQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRE 164
L EL++ +S+ EE Y +S A L + +I Q D +K + + E Q +E
Sbjct: 1394 LDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQA----KE 1449
Query: 165 NEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIP--DGTPNGDVSHEPV 222
++E+ K+L Q +C + Q K EE+ E R + ++ K +I + E +
Sbjct: 1450 HDERIKQL--QVELCEMKQ-KPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEEL 1506
Query: 223 A---GAITVVSQEAAQVLE--SAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKC 277
+ G I +++ A V SA D L +LA +EE I ++ L E +
Sbjct: 1507 SLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLS 1566
Query: 278 SRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISE---YKFKLSKAEQDITTLEQSISRLE 334
S + L GL + E++ + +I+E ++ K + +++ L QS +
Sbjct: 1567 SSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVS 1626
Query: 335 GQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMK 390
+ AE + V + ++ EK++L +LR+ +E E + +E+MK
Sbjct: 1627 NE-------AERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMK 1675
Score = 43.5 bits (101), Expect = 3e-04
Identities = 52/262 (19%), Positives = 109/262 (41%), Gaps = 23/262 (8%)
Query: 110 SELRESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKS 169
+EL S +E+K+K M ++ + D +++Q ++ + +NE+
Sbjct: 357 AELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQ--DKNEQAV 414
Query: 170 KELERQKHMCSVLQHKMEELKEGLRQRD-ELIEKHGLVIIPDGTPNGD--VSHEPVAG-- 224
+ + + + LQ K +E+ + L + + E PD G V+ E +A
Sbjct: 415 QSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQ 474
Query: 225 --AITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDG 282
+ + +++ A +L S + L +L E E+L SQI L+ Q ++
Sbjct: 475 KRVVELENEKGALLLSS-------IELEELKAENEKLSSQITLLEAQNRTGEADREVSEI 527
Query: 283 TVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKT 342
++ D+A ++ S ++ + + E F E + LE ++ E L+ +
Sbjct: 528 SIVDIANKRSSS-------AEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQL 580
Query: 343 AAENAEKVEDELKAEKRKLQRE 364
+ AE+ + E+ +K Q E
Sbjct: 581 QGKRAEEADHEVLDQKEMKQME 602
Score = 42.7 bits (99), Expect = 6e-04
Identities = 76/378 (20%), Positives = 151/378 (39%), Gaps = 27/378 (7%)
Query: 19 AEDEALSNIAREAE------ARLAAKRAARAEARDIRMRELERQQKELDEKSDKQYAENY 72
++DE L +++ + E + A+ RD ELE+ +K +E + A+
Sbjct: 2812 SKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKS-EEGKQRSAAQPS 2870
Query: 73 TRPSSRNSASATTPLSGNSSRRGSGDTSSL------IDPD-TSLSELRESLSEVEEKYKK 125
T P+ S N R + +L I+ + T L L+ L E ++K K
Sbjct: 2871 TSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKA 2930
Query: 126 AMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHK 185
+ +L E NL +Q + + +E+ ++ E R E+ + + S LQ+
Sbjct: 2931 FQIMQEELRQE--NLSWQHELHQLRMEKSSWEIHE-RRMKEQYLMAISDKDQQLSHLQNL 2987
Query: 186 MEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPL 245
+ EL+ Q L ++ P+ + + D S V + +Q + E +
Sbjct: 2988 IRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQK--- 3044
Query: 246 DVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQR-- 303
++R+++L +LL + L +QL + Q N GDL + Q E+Q
Sbjct: 3045 ELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGP 3104
Query: 304 ---DANRQISEYKFKLSKAE--QDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEK 358
D + K + + +++ +QS S + Q+ + K+ +E + ++
Sbjct: 3105 LNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQR 3164
Query: 359 RKLQRELRTALDKIEEME 376
+ L A ++I +E
Sbjct: 3165 VAAENALSVAEEQIRRLE 3182
Score = 42.4 bits (98), Expect = 8e-04
Identities = 82/420 (19%), Positives = 169/420 (40%), Gaps = 51/420 (12%)
Query: 5 ASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKELDEKS 64
AS + + + + +++ + ++ E + A + D ++ELE + +E++
Sbjct: 2365 ASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEEN 2424
Query: 65 DKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRESL----SEVE 120
EN N T + + S + +SL R+ + ++E
Sbjct: 2425 IVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLE 2484
Query: 121 EKYKKAMVSNAQLDNE----KNNLIYQVDTLKDVIEEQEEQMAEF------YREN----- 165
E++ ++ QL E N L ++ L+ +++ + A+ YRE+
Sbjct: 2485 ERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVI 2544
Query: 166 ----EEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEP 221
++ + LE Q L++K +L+E L++ +E E D+S E
Sbjct: 2545 TIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKE- 2603
Query: 222 VAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEE------LLSQIRKLKLQLEEE-- 273
+ +SQ QV EG L + +L ++EE L S +K +LEEE
Sbjct: 2604 IESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELV 2663
Query: 274 --RQKCSRNDGTVGD-----LAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTL 326
+++ ++ G + D L L + + + E + A +++E L + EQ + +
Sbjct: 2664 CVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETET-AEERVAELARDLVEMEQKLLMV 2722
Query: 327 EQSISRLEGQVLRY-------KTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTN 379
+ L Q+ + + + ++A + DEL KRK L+ L +++E + N
Sbjct: 2723 TKENKGLTAQIQSFGRSMSSLQNSRDHANEELDEL---KRKYDASLK-ELAQLKEQGLLN 2778
Score = 40.0 bits (92), Expect = 0.004
Identities = 67/318 (21%), Positives = 122/318 (38%), Gaps = 42/318 (13%)
Query: 106 DTSLSELRESLSEVEEKYK-KAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRE 164
D +L E R++ +K K A L+ + Q T+ + EEQ+++ +
Sbjct: 79 DEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKS 138
Query: 165 NEEKSKELERQKH-------MCSVLQHKM------------EELKEGLRQRDELIEKHGL 205
+ E+ E+E+ KH + S LQ ++ E++E + + +L EK
Sbjct: 139 STEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEF 198
Query: 206 VIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLD--VRLRKLAGEKEELLSQI 263
+ T +S A V +E E+ D ++L A + E+ ++
Sbjct: 199 I----STLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKL 254
Query: 264 RKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANR-QISEYKFKLSKAEQD 322
R L+ +LEE + L G DL E+ R QI + + +AE +
Sbjct: 255 RVLQRKLEEHEE----------SLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHN 304
Query: 323 ITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHL 382
R E ++L K E AE+ K LQ E+ L++ E+ + L
Sbjct: 305 TLRNTVETEREESKILLEKMELEVAER-----KLSFHNLQEEMHHLLEQFEQAGQAQAEL 359
Query: 383 AKRLEKMKANRTALLAQQ 400
R ++ A + ++
Sbjct: 360 ESRYSALEQKHKAEMEEK 377
Score = 36.2 bits (82), Expect = 0.054
Identities = 87/432 (20%), Positives = 183/432 (42%), Gaps = 63/432 (14%)
Query: 22 EALSNIAREAEARLAAKRAARAEARDIRMRELERQQKELDEKSDKQYAENYTRPSS---R 78
E + +++ EA+++ + E D++++ E+ +S Q E+ + R
Sbjct: 796 EQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVR 855
Query: 79 NSASATTPLSGNSSRRGSGDTSS---LIDPDTSLSELRESLSEVEEKYKKAMVSNA---- 131
+ +S LS S++ T L++ + L++++ E +++ + S
Sbjct: 856 HISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMV 915
Query: 132 QLDNEKNNLIYQVDTLKD---VIEEQEEQMAEFYRENEEKSKELERQKHMCSV------- 181
QL+ EK +L ++ TLK+ ++ EE E E+ E S L++ S
Sbjct: 916 QLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKE 975
Query: 182 -LQHKMEELKE-----------GLRQRDELIEK-----HGLVIIPDGTPNGDVSHEPVAG 224
LQH+ + LK+ L R EL+++ L + D + E G
Sbjct: 976 ELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERG 1035
Query: 225 AITV--VSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRK---LKLQLEEERQKCSR 279
+ ++E ++ ++ +++ L++ EKE L IRK KL EE+ Q +
Sbjct: 1036 EVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVK 1095
Query: 280 N-DGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVL 338
+ T+ D + + ++ + N+ I + KL + D + + S++ ++ V+
Sbjct: 1096 QMNQTLQDKT-----NQIDLLQAEISENQAIIQ---KLITSNTDASDGD-SVALVKETVV 1146
Query: 339 RYKTAAENAEKVEDELKA-------EKRKLQRELRTALDK----IEEMEMTNSHLAKRLE 387
++E + EL+ EK +LQ++L+ AL +++ + HL + L+
Sbjct: 1147 ISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELK 1206
Query: 388 KMKANRTALLAQ 399
+ K + L Q
Sbjct: 1207 QQKDDYNRLQEQ 1218
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 66.2 bits (160), Expect = 5e-11
Identities = 78/387 (20%), Positives = 167/387 (43%), Gaps = 26/387 (6%)
Query: 21 DEALSNIAREAEARLAAKRAAR--AEARDIRMRELERQQKELDEKSDKQYAENYTRPSSR 78
+EAL + +E + ++A+RA EA + + ++QK+L EK ++ + +
Sbjct: 877 EEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLK 936
Query: 79 NSASATTPLSGNSSRRGSGDTSSLIDPD-TSLSELRESLSEVEEKYKKAM------VSNA 131
N G + + + + +++ TS EL+ L E +EK ++ + +
Sbjct: 937 NEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEK 996
Query: 132 QLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKE 191
L+ EK+ L ++D + EE++ ++ R +E + + + L++++E
Sbjct: 997 TLEAEKSRLTAM--KMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSH 1054
Query: 192 GLRQRDELIEKHGLVI------IPDGTPNGDVSHEPVAGAITVVSQEAAQVL-ESAGEGP 244
R L+++ + + + N D+ E ++ + + Q ++L E A
Sbjct: 1055 LKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQD 1114
Query: 245 LDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCS-RNDGTVGDLAGLQNGSDLQFIEMQR 303
L+ L + ++L S+I L+ ++ + + + +L + +Q
Sbjct: 1115 LECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQL 1174
Query: 304 DANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQR 363
R + K + + + + +L +L ++ K E AE+ D L++ K+KLQR
Sbjct: 1175 SNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQR 1234
Query: 364 ELRTALDKIEEMEMTNSHLAKRLEKMK 390
EL E+M+M N HL +L MK
Sbjct: 1235 ELE------EQMDM-NEHLQGQLNSMK 1254
Score = 52.8 bits (125), Expect = 6e-07
Identities = 81/409 (19%), Positives = 175/409 (42%), Gaps = 40/409 (9%)
Query: 3 TPASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKELDE 62
+P SG K+ VK SA + + + + L ++ A+ I L+ + D+
Sbjct: 514 SPDSGAKKISVKTFPSASNTQATPDLLKGQQELT-QQTNEETAKQILYNYLKEGSTDNDD 572
Query: 63 KSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSEVEEK 122
+ ++ + + + S +A + N + + + L++ S+L ++E++ +
Sbjct: 573 ATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQK---SKLTIEVAELQRQ 629
Query: 123 YKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVL 182
+ + + + E+ + ++ L+ E+ E+ + + EE EL +K++ +
Sbjct: 630 LQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGEL--RKNLEELF 687
Query: 183 QHKMEELKEGLRQRD---ELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLES 239
Q KME + RD +L E H D + S + GA+ +A Q L+
Sbjct: 688 QVKMEREQHQTEIRDLQDQLSEMH------DELDSAKRSEDREKGALIEELLQAKQDLQ- 740
Query: 240 AGEGPLDVRLRKLAGEKEELLS----QIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSD 295
D+ + K E+E+LL ++ LK L+EE S +D + L Q ++
Sbjct: 741 ------DLLIAK--EEQEDLLRKRERELTALKGALKEE---VSSHDQEMDKLKE-QYDAE 788
Query: 296 LQFI-EMQRDANRQISEYKFKLSKAEQD-------ITTLEQSISRLEGQVLRYKTAAENA 347
LQ + E +A + + + + +EQD + L++ +L+G+ +
Sbjct: 789 LQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQL 848
Query: 348 EKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTAL 396
++ ++LK ++ K + L+ +I ++E H K ++ + R AL
Sbjct: 849 QRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRAL 897
Score = 45.8 bits (107), Expect = 7e-05
Identities = 70/314 (22%), Positives = 131/314 (41%), Gaps = 59/314 (18%)
Query: 107 TSLSELRESLSEVEEKYKKAMVSNAQLDNEKNNLIYQV----DTLKDVIEEQEEQMAEFY 162
T + +L++ LSE+ ++ A S D EK LI ++ L+D++ +EEQ
Sbjct: 698 TEIRDLQDQLSEMHDELDSAKRSE---DREKGALIEELLQAKQDLQDLLIAKEEQEDLLR 754
Query: 163 RENEEKSKELERQKHMCSVLQHKMEELKE-------GLRQRDELIEKHGLVIIPDGTPNG 215
+ E + K S +M++LKE LR+ E K+ V+
Sbjct: 755 KRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVL----ASRS 810
Query: 216 DVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQ 275
+ S + AG ++ ++L+ E KL G EEL ++ +L+ Q+E+ +
Sbjct: 811 NTSEQDQAG-----TEMRVKLLQEENE--------KLQGRSEELERRVAQLQRQIEDLK- 856
Query: 276 KCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSI-SRLE 334
GD A + + ++ RQ+ E K E++ + +++ + LE
Sbjct: 857 ---------GDEAKAK-----ETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELE 902
Query: 335 GQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKM----- 389
+ +++ ++LK E + ++ R EME HL K +EK+
Sbjct: 903 AAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLK----NEMENERWHLGKTIEKLQKEMA 958
Query: 390 ---KANRTALLAQQ 400
+A+RT+ L Q
Sbjct: 959 DIVEASRTSTLELQ 972
Score = 44.7 bits (104), Expect = 2e-04
Identities = 57/249 (22%), Positives = 99/249 (39%), Gaps = 58/249 (23%)
Query: 13 VKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKELDEKSDKQYAENY 72
+ +R S E + + E L +RAAR + ++ LERQ K+L KS + E
Sbjct: 1087 LSERISRSREQMEQLRNE----LLQERAARQDLECDKI-SLERQNKDL--KSRIIHLEGS 1139
Query: 73 TRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSEVEEKYKKAMVSNAQ 132
R SS+ G ++ + ++EL + L E +SN +
Sbjct: 1140 YR----------------SSKEGL-----VVQMEARIAELEDRLESEERDRANLQLSNRR 1178
Query: 133 LDNEKNNLIYQVD------------------TLKDVIEEQEEQMAEFYRENEEKSKELER 174
L+ + L+ QVD +K +EE EE++ ++ +ELE
Sbjct: 1179 LERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEE 1238
Query: 175 QKHMCSVLQHKMEELKEGLRQR-------DELIEKHGLVIIPDGTPNGDVSHEPVAGAIT 227
Q M LQ ++ +K+ LR + D++ + L T G + PV+ +
Sbjct: 1239 QMDMNEHLQGQLNSMKKDLRLKKLPSKVLDDMDDDDDL-----STDGGSLYEAPVSYTFS 1293
Query: 228 VVSQEAAQV 236
S A+Q+
Sbjct: 1294 KDSTVASQI 1302
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 64.3 bits (155), Expect = 2e-10
Identities = 77/396 (19%), Positives = 160/396 (40%), Gaps = 59/396 (14%)
Query: 5 ASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKELDEKS 64
A ++T V D F+++ +A + +A A ++E + +R ++LE +K++
Sbjct: 704 AKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLR-QQLEAAEKQIKHLE 762
Query: 65 DKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSEVEEKYK 124
++ AE S ++S T L G + L+ L+E+LSEV +
Sbjct: 763 IEKNAE------SSKASSITRELQGR---------------ELKLTNLQENLSEVSQV-- 799
Query: 125 KAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQH 184
K L ++ LK+ E E+ R +E +L +++ ++L
Sbjct: 800 ------------KETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSS 847
Query: 185 KMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGP 244
+E+L+E L + + D E + A + + A++++ +G+
Sbjct: 848 DLEKLRENLADMEAKFREK------------DEREEQLIKAKEKLENDIAEIMKMSGDN- 894
Query: 245 LDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRD 304
+L K+ E + +L+L+L + + S ++ D+ S + + +
Sbjct: 895 -SSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEE 953
Query: 305 ANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRE 364
+++ KLS E+ + T L+ RY+ A + +E+ + LQ+
Sbjct: 954 EKKELER---KLSDLEKKMETSHNQCQELKA---RYERATSETKTKHEEIL---QNLQKT 1004
Query: 365 LRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ 400
L DK++ NS L + LE+++ A Q
Sbjct: 1005 LLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQ 1040
Score = 50.1 bits (118), Expect = 4e-06
Identities = 84/403 (20%), Positives = 162/403 (40%), Gaps = 55/403 (13%)
Query: 13 VKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKELDEKSDKQYAENY 72
+K++F+ E ++ R + + K + E ++ +LE+ ++ L + K + E
Sbjct: 810 LKEKFAEASEEAVSVQRSMQETVN-KLHQKEEQFNMLSSDLEKLRENLADMEAK-FREKD 867
Query: 73 TRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSEVEEKYKKAMVSNAQ 132
R A + SGD SS + ELR +VEE K +N
Sbjct: 868 EREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMND--ELRLKERDVEELQLKLTKAN-- 923
Query: 133 LDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEG 192
N + +++D+ + E+ E +++EE+ KELER+ S L+ KME
Sbjct: 924 -----ENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERK---LSDLEKKMETSHNQ 975
Query: 193 LRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKL 252
++ E+ T HE ++L++ + LD KL
Sbjct: 976 CQELKARYER--------ATSETKTKHE--------------EILQNLQKTLLDTE-DKL 1012
Query: 253 AGEKEE---LLSQIRKLKLQLEEERQKCSRNDG-TVGDLAGLQNGSDLQFIEMQRDANRQ 308
G +EE LL ++ +L+ Q ++ + + D + + + L +E + N +
Sbjct: 1013 KGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAK 1072
Query: 309 -------ISEYKFK----LSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAE 357
+ E K L+K+++ +T Q + ++ K AA + L+ E
Sbjct: 1073 LQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEE 1132
Query: 358 KRKLQRELRTALDKI---EEMEMTNSHLAKRLEKMKANRTALL 397
KL EL + D++ +++E S L +L +MK + +
Sbjct: 1133 NVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFI 1175
Score = 40.8 bits (94), Expect = 0.002
Identities = 93/480 (19%), Positives = 180/480 (37%), Gaps = 94/480 (19%)
Query: 1 MGTPASGRKRTPVKDRFSAEDEALSNIA-REAEARLAAKRAARAEARDIRMRELERQQKE 59
M T ++ KR+P S+ S+++ R + L + ++R + L+ KE
Sbjct: 300 MATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKE 359
Query: 60 LDEKSDKQYAE-NYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELR----- 113
+ ++ AE + R + S + + G +++ + + +LR
Sbjct: 360 KQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEA 419
Query: 114 ------ESLSEVEEKYKKAMVSNAQLDNE---KNNLIYQVDTLKDVIEEQEEQMAEFYRE 164
E L+++EE+ +K +++ E K +L + K I E E+ +A +E
Sbjct: 420 ADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDLALRVQE 479
Query: 165 NEEKSKELERQK------------HMCSVLQHKME-----------ELKEGLRQRDELIE 201
E + LE K S LQ K+E LKE R+E +
Sbjct: 480 VAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQ 539
Query: 202 KHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQV-------LESA------GEGPLDVR 248
K + + T +E + + ++E + V LE+A L V
Sbjct: 540 KE-IKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVS 598
Query: 249 LRKLAG----EKEELLSQIRKLKLQLEEERQKC-SRNDGTVGDLAGLQNGSDLQFIEMQR 303
K G E EL +QI K++L + E + ++ D A + +++ +
Sbjct: 599 FSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIK 658
Query: 304 DANRQISEYKFKLSKAE-QDITTLEQSISRLEGQVLRYKTAA------------------ 344
+ + + KL KAE Q + +E ++++L+ ++ K
Sbjct: 659 EKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTS 718
Query: 345 ------------ENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKAN 392
+ K E K+E +KL+++L A +I+ +E + K E KA+
Sbjct: 719 QLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLE-----IEKNAESSKAS 773
Score = 37.7 bits (86), Expect = 0.019
Identities = 32/153 (20%), Positives = 70/153 (45%), Gaps = 9/153 (5%)
Query: 255 EKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEY-- 312
EK ELL+Q+ + K ++E+ + + T GDL + +E+++D ++ E
Sbjct: 423 EKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDLALRVQEVAE 482
Query: 313 ---KFKLSKAEQDI---TTLEQSISRLEGQVLRYKTAAE-NAEKVEDELKAEKRKLQREL 365
+ + +K D+ +L Q IS L+ ++ +T + +++ A + Q+E+
Sbjct: 483 LRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEI 542
Query: 366 RTALDKIEEMEMTNSHLAKRLEKMKANRTALLA 398
+ E++ N L +LE + ++A
Sbjct: 543 KALYTATEKLSKENESLKSKLEHANKENSDVIA 575
Score = 37.4 bits (85), Expect = 0.024
Identities = 75/348 (21%), Positives = 140/348 (40%), Gaps = 53/348 (15%)
Query: 73 TRPSSR--NSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSEVEEKYKKAMVSN 130
T SSR S TT L + L + D +E+ ++ S V E ++ ++
Sbjct: 337 TETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALAR 396
Query: 131 AQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELK 190
D L ++D L+ ++E + RE E +LE +K LQ ++EE
Sbjct: 397 DGHDQHVLELEAKMDQLRTMVEAAD-------REKVELLNQLEEEKRKVEDLQFRVEE-- 447
Query: 191 EGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLR 250
E I K L +V+ I + ++ A ++ E +
Sbjct: 448 -------ESITKGDL----------EVATVSEKSRIMELEKDLALRVQEVAELRRRLESN 490
Query: 251 KLAGEKE---ELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANR 307
K AG+ + LL +I L+ +LE R R ++ + G + + + I+ A
Sbjct: 491 KPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATE 550
Query: 308 QISE----YKFKL---SKAEQDITTLEQSISRLEGQVLRYKTAAE----------NAEKV 350
++S+ K KL +K D+ L + S+LE + ++ A E E
Sbjct: 551 KLSKENESLKSKLEHANKENSDVIALWK--SKLETAIASHQQAMEELKVSFSKGLGTETA 608
Query: 351 E-DELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALL 397
E ELK + K++ + + ++ ++ + +S A ++M+A R L+
Sbjct: 609 EFAELKTQIEKMRLDYQHEIENLQNQQ--DSERAAHAKEMEALRAKLM 654
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 64.3 bits (155), Expect = 2e-10
Identities = 77/396 (19%), Positives = 160/396 (40%), Gaps = 59/396 (14%)
Query: 5 ASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKELDEKS 64
A ++T V D F+++ +A + +A A ++E + +R ++LE +K++
Sbjct: 739 AKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLR-QQLEAAEKQIKHLE 797
Query: 65 DKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSEVEEKYK 124
++ AE S ++S T L G + L+ L+E+LSEV +
Sbjct: 798 IEKNAE------SSKASSITRELQGR---------------ELKLTNLQENLSEVSQV-- 834
Query: 125 KAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQH 184
K L ++ LK+ E E+ R +E +L +++ ++L
Sbjct: 835 ------------KETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSS 882
Query: 185 KMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGP 244
+E+L+E L + + D E + A + + A++++ +G+
Sbjct: 883 DLEKLRENLADMEAKFREK------------DEREEQLIKAKEKLENDIAEIMKMSGDN- 929
Query: 245 LDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRD 304
+L K+ E + +L+L+L + + S ++ D+ S + + +
Sbjct: 930 -SSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEE 988
Query: 305 ANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRE 364
+++ KLS E+ + T L+ RY+ A + +E+ + LQ+
Sbjct: 989 EKKELER---KLSDLEKKMETSHNQCQELKA---RYERATSETKTKHEEIL---QNLQKT 1039
Query: 365 LRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ 400
L DK++ NS L + LE+++ A Q
Sbjct: 1040 LLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQ 1075
Score = 50.1 bits (118), Expect = 4e-06
Identities = 84/403 (20%), Positives = 162/403 (40%), Gaps = 55/403 (13%)
Query: 13 VKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKELDEKSDKQYAENY 72
+K++F+ E ++ R + + K + E ++ +LE+ ++ L + K + E
Sbjct: 845 LKEKFAEASEEAVSVQRSMQETVN-KLHQKEEQFNMLSSDLEKLRENLADMEAK-FREKD 902
Query: 73 TRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSEVEEKYKKAMVSNAQ 132
R A + SGD SS + ELR +VEE K +N
Sbjct: 903 EREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMND--ELRLKERDVEELQLKLTKAN-- 958
Query: 133 LDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEG 192
N + +++D+ + E+ E +++EE+ KELER+ S L+ KME
Sbjct: 959 -----ENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERK---LSDLEKKMETSHNQ 1010
Query: 193 LRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKL 252
++ E+ T HE ++L++ + LD KL
Sbjct: 1011 CQELKARYER--------ATSETKTKHE--------------EILQNLQKTLLDTE-DKL 1047
Query: 253 AGEKEE---LLSQIRKLKLQLEEERQKCSRNDG-TVGDLAGLQNGSDLQFIEMQRDANRQ 308
G +EE LL ++ +L+ Q ++ + + D + + + L +E + N +
Sbjct: 1048 KGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAK 1107
Query: 309 -------ISEYKFK----LSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAE 357
+ E K L+K+++ +T Q + ++ K AA + L+ E
Sbjct: 1108 LQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEE 1167
Query: 358 KRKLQRELRTALDKI---EEMEMTNSHLAKRLEKMKANRTALL 397
KL EL + D++ +++E S L +L +MK + +
Sbjct: 1168 NVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFI 1210
Score = 37.4 bits (85), Expect = 0.024
Identities = 70/327 (21%), Positives = 127/327 (38%), Gaps = 47/327 (14%)
Query: 73 TRPSSR--NSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSEVEEKYKKAMVSN 130
T SSR S TT L + L + D +E+ ++ S V E ++ ++
Sbjct: 337 TETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALAR 396
Query: 131 AQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELK 190
D L ++D L+ ++E + RE E +LE +K LQ ++EE
Sbjct: 397 DGHDQHVLELEAKMDQLRTMVEAAD-------REKVELLNQLEEEKRKVEDLQFRVEE-- 447
Query: 191 EGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLR 250
+ GD+ + + E + + E L L
Sbjct: 448 -------------------ESITKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRELE 488
Query: 251 ----KLAGEKEELLSQIRKLKLQLEE--ERQKCSRNDGTVGD----LAGLQNGSDLQ-FI 299
EK ++ + L L+++E E ++ ++ GD L+ LQ S LQ +
Sbjct: 489 DTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKL 548
Query: 300 EMQR-DANRQISEYKFKLSKAEQ----DITTLEQSISRLEGQVLRYKTAAENAEKV-EDE 353
E+ R D R+I+ K E+ +I L + +L + K+ E+A K D
Sbjct: 549 EVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDV 608
Query: 354 LKAEKRKLQRELRTALDKIEEMEMTNS 380
+ K KL+ + + +EE++++ S
Sbjct: 609 IALWKSKLETAIASHQQAMEELKVSFS 635
Score = 35.8 bits (81), Expect = 0.070
Identities = 71/388 (18%), Positives = 151/388 (38%), Gaps = 32/388 (8%)
Query: 16 RFSAEDEALSNIAREAEARLAAKRAARAEARDI-RMRELERQQKELDEKSDKQYAENYTR 74
+F E+E+++ E + +L R E + + ++ Q+EL++ +E +R
Sbjct: 442 QFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEK-SR 500
Query: 75 PSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSEVEEKYKKAMVSNA-QL 133
A RR D D SLS L+E +S ++EK + + ++
Sbjct: 501 IMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQE-ISSLQEKLEVTRTDHQREI 559
Query: 134 DNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELER-QKHMCSVLQHKMEELKEG 192
+ K + + +T + I+ + +ENE +LE K V+ +L+
Sbjct: 560 TSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETA 619
Query: 193 LRQRDELIEKHGLVIIPD-GTPNGDVSH-EPVAGAITVVSQEAAQVLESAGEGPLDVRLR 250
+ + +E+ + GT + + + + + Q + L++ + +
Sbjct: 620 IASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAK 679
Query: 251 KLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQIS 310
++ + +L+ I++ + LE R K L D +EM+ N+ +
Sbjct: 680 EMEALRAKLMKVIKEKENSLEAIRSK-------------LDKAEDQHLVEMEDTLNK-LQ 725
Query: 311 EYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENA------EKVEDELKAEKRKLQRE 364
E + K+ + E + ++ + K E K E K+E +KL+++
Sbjct: 726 EAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQ 785
Query: 365 LRTALDKIEEMEMTNSHLAKRLEKMKAN 392
L A +I+ +E + K E KA+
Sbjct: 786 LEAAEKQIKHLE-----IEKNAESSKAS 808
Score = 30.4 bits (67), Expect = 3.0
Identities = 55/342 (16%), Positives = 131/342 (38%), Gaps = 42/342 (12%)
Query: 83 ATTPLSG--NSSRRGSGDTSSLIDPDTSLSELRESLSEVEEKYKKAMVSNAQLDNEKNNL 140
+TTP N+ RR TS+ + S S L S+S V L +
Sbjct: 285 STTPAKAKANAVRRVMATTSASLKRSPSASSL-SSMSSVASSVSSRPSRTGLLTETSSRY 343
Query: 141 IYQVD---TLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRD 197
++ L++ ++E+++ + + E + + E+ + ++ ++ ++G Q
Sbjct: 344 ARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQ-- 401
Query: 198 ELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKE 257
H L + + + + + +E ++L E V + E+E
Sbjct: 402 -----HVLEL--------EAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEE 448
Query: 258 ELL------------SQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDA 305
+ ++I++L+ L E+ K + + D + +E+++D
Sbjct: 449 SITKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDL 508
Query: 306 NRQISEY-----KFKLSKAEQDIT---TLEQSISRLEGQVLRYKTAAENA-EKVEDELKA 356
++ E + + +K D+ +L Q IS L+ ++ +T + +++ A
Sbjct: 509 ALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGA 568
Query: 357 EKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLA 398
+ Q+E++ E++ N L +LE + ++A
Sbjct: 569 REETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIA 610
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 63.2 bits (152), Expect = 4e-10
Identities = 71/293 (24%), Positives = 123/293 (41%), Gaps = 40/293 (13%)
Query: 107 TSLSELRESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENE 166
T + L+ L + + ++ + + +L E L ++ K +EE + E E
Sbjct: 869 TEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEE 928
Query: 167 EKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAI 226
E+ + L+ +K +Q ++EL+E L + + +K L E V
Sbjct: 929 ERCQHLQAEK---KKMQQNIQELEEQLEEEESARQKLQL--------------EKVTTEA 971
Query: 227 TVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGD 286
+ E Q++ L+ + KLA EK+ L +I + L EE +K
Sbjct: 972 KLKKLEEEQII-------LEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSK-------S 1017
Query: 287 LAGLQNGSDLQFIEMQ---RDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTA 343
LA L+N + +++ R +Q E + K E D T L I+ L+ Q+ K
Sbjct: 1018 LAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKM- 1076
Query: 344 AENAEKVEDELKAEKRKLQREL---RTALDKIEEMEMTNSHLAKRLEKMKANR 393
K E+EL+A +++ E AL KI E+E S L + LE +A+R
Sbjct: 1077 --QLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASR 1127
Score = 55.1 bits (131), Expect = 1e-07
Identities = 86/406 (21%), Positives = 160/406 (39%), Gaps = 83/406 (20%)
Query: 13 VKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKELDEKSDKQYAENY 72
+K + + ++E L E A K A ++RELE Q EL E + + A
Sbjct: 1074 LKMQLAKKEEELQAALARVEEEAAQKNMALK-----KIRELESQISELQEDLESERA--- 1125
Query: 73 TRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSEVEEKYKKAMVSNAQ 132
SRN A + +L E L ++ + + + S A
Sbjct: 1126 ----SRNKA------------------------EKQKRDLGEELEALKTELEDTLDSTAA 1157
Query: 133 LDNEKNNLIYQVDTLKDVIEEQ----EEQMAEFYRENEEKSKELERQKHMCSVLQHKMEE 188
++ +V+ LK +EE+ E Q+ E +++ + +EL Q ++ +E+
Sbjct: 1158 QQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEK 1217
Query: 189 LKEGLR-QRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDV 247
K+ L +R EL + +++ GD H+ + AQ+ E L V
Sbjct: 1218 AKQTLENERGELANEVKVLL----QGKGDSEHKR--------KKVEAQLQE------LQV 1259
Query: 248 RLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQ---RD 304
+ + + EL ++ KL+++L+ S++D L + + Q + Q ++
Sbjct: 1260 KFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQE 1319
Query: 305 ANRQISEYKFKLSKAEQDITT--------------LEQSISRLEGQVLRYKTAAENAEKV 350
NRQ KL + E + + LE+ I+ L QV K E++
Sbjct: 1320 ENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGC 1379
Query: 351 EDELKAEKRKLQRELRTALDKIEE-------MEMTNSHLAKRLEKM 389
+ + KRKLQ++L + EE +E T + L + L+ +
Sbjct: 1380 LETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDL 1425
Score = 53.9 bits (128), Expect = 2e-07
Identities = 74/371 (19%), Positives = 147/371 (39%), Gaps = 38/371 (10%)
Query: 21 DEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKELDEKSDKQYAENYTRPSSRNS 80
+ +S + + E+ A++ A + RD+ ELE + EL++ D A+ R
Sbjct: 1110 ESQISELQEDLESERASRNKAEKQKRDLG-EELEALKTELEDTLDSTAAQQELRSKREQE 1168
Query: 81 ASATTPLSGNSSRRGSGDTSSLIDPDT-SLSELRESLSEVEEKYKKAMVSNAQLDNEKNN 139
+ ++ + + ++ EL E L + + + L+NE+
Sbjct: 1169 VNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGE 1228
Query: 140 LIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDEL 199
L +V L + ++E K K++E Q LQ + EG R R EL
Sbjct: 1229 LANEVKVL-----------LQGKGDSEHKRKKVEAQ------LQELQVKFNEGERVRTEL 1271
Query: 200 IEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLE--SAGEGPLDVRLRKLAGEKE 257
+K V + V G ++ +++++ + SA E L L E
Sbjct: 1272 ADK---------VTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENR 1322
Query: 258 ELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLS 317
+ LS KLK Q+E+E+ + + ++ + Q + + Q+++ K K+
Sbjct: 1323 QKLSLSTKLK-QVEDEKNSFREQ---LEEEEEAKHNLEKQIATL----HAQVADMKKKME 1374
Query: 318 KAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEM 377
+ + T E+ +L+ + E D+L+ K +LQ+EL L ++
Sbjct: 1375 DSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQ 1434
Query: 378 TNSHLAKRLEK 388
+ +L K+ +K
Sbjct: 1435 SACNLEKKQKK 1445
Score = 52.4 bits (124), Expect = 7e-07
Identities = 72/405 (17%), Positives = 162/405 (40%), Gaps = 65/405 (16%)
Query: 8 RKRTPVKDRFSAEDEALSNIAREAE-----ARLAAKRAARAEARDIRMRELERQQKELDE 62
+++ ++DR + E +N+ E E A+L K A + R+R E+Q++EL++
Sbjct: 992 KEKKLLEDRIA---EFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEK 1048
Query: 63 KSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDP----DTSLSELRESLSE 118
+ R+ GD++ L D ++EL+ L++
Sbjct: 1049 ----------------------------TRRKLEGDSTDLSDQIAELQAQIAELKMQLAK 1080
Query: 119 VEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHM 178
EE+ + A+ + +KN + ++ L+ I E +E + + K+
Sbjct: 1081 KEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEE 1140
Query: 179 CSVLQHKMEELKEGLRQRDELIEK--HGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQV 236
L+ ++E+ + + EL K + I+ +HE I + Q+ +Q
Sbjct: 1141 LEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHE---AQIQEMRQKHSQA 1197
Query: 237 LESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAG--LQNGS 294
+E E E L Q +++K LE+ +Q G + + LQ
Sbjct: 1198 VE----------------ELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKG 1241
Query: 295 DLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDEL 354
D + ++ Q+ E + K ++ E+ T L +++L+ ++ ++ +L
Sbjct: 1242 DSE--HKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKL 1299
Query: 355 KAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQ 399
+ L+ +L+ + ++E L+ +L++++ + + Q
Sbjct: 1300 TKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQ 1344
Score = 51.6 bits (122), Expect = 1e-06
Identities = 62/275 (22%), Positives = 120/275 (43%), Gaps = 28/275 (10%)
Query: 140 LIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDEL 199
L +V L V ++EE MA+ + + K+L + + + + + + E L+ +++L
Sbjct: 830 LFTKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQL 889
Query: 200 IEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQV---LESAGEGPLDVRLRKLAGEK 256
+ L E + +T QE ++ LE+ E + R + L EK
Sbjct: 890 QAETELC----------AEAEELRARLTAKKQELEEICHDLEARVEEE-EERCQHLQAEK 938
Query: 257 EELLSQIRKLKLQLEEE---RQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANR------ 307
+++ I++L+ QLEEE RQK T A L+ + Q I ++
Sbjct: 939 KKMQQNIQELEEQLEEEESARQKLQLEKVTTE--AKLKKLEEEQIILEDQNCKLAKEKKL 996
Query: 308 ---QISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRE 364
+I+E+ L++ E+ +L + ++ E + + EK EL+ +RKL+ +
Sbjct: 997 LEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGD 1056
Query: 365 LRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQ 399
D+I E++ + L +L K + A LA+
Sbjct: 1057 STDLSDQIAELQAQIAELKMQLAKKEEELQAALAR 1091
Score = 51.2 bits (121), Expect = 2e-06
Identities = 71/309 (22%), Positives = 133/309 (43%), Gaps = 40/309 (12%)
Query: 111 ELRESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYREN---EE 167
EL E ++E + ++ L EK + + L++ +EE+E + E E
Sbjct: 912 ELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEA 971
Query: 168 KSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAIT 227
K K+LE ++ + K+ + K+ L R I + T N E
Sbjct: 972 KLKKLEEEQIILEDQNCKLAKEKKLLEDR-----------IAEFTTNLTEEEEKSKSLAK 1020
Query: 228 VVSQEAAQVL--------ESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSR 279
+ ++ A + E L+ RKL G+ +L QI +L+ Q+ E + + ++
Sbjct: 1021 LKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAK 1080
Query: 280 NDGTV-GDLAGLQNGSDLQFIEMQ--RDANRQISEYKFKL-------SKAEQDITTLEQS 329
+ + LA ++ + + + ++ R+ QISE + L +KAE+ L +
Sbjct: 1081 KEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEE 1140
Query: 330 ISRLEGQV--LRYKTAA--ENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNS----H 381
+ L+ ++ TAA E K E E+ K+ L+ E +T +I+EM +S
Sbjct: 1141 LEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEE 1200
Query: 382 LAKRLEKMK 390
LA++LE+ K
Sbjct: 1201 LAEQLEQTK 1209
Score = 47.8 bits (112), Expect = 2e-05
Identities = 90/442 (20%), Positives = 171/442 (38%), Gaps = 84/442 (19%)
Query: 10 RTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKELDEKSDKQYA 69
RT ++D S++D+ + + +KRA + +++ +LE + EL D +
Sbjct: 1503 RTEMEDLMSSKDD----VGKSVHELEKSKRALEQQVEEMKT-QLEELEDELQATEDAKLR 1557
Query: 70 ENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSEVEEKYKK---A 126
+ + A L G D S + ++RE +E+E++ K+ A
Sbjct: 1558 LEVNLQAMK--AQFERDLQGR-------DEQSEEKKKQLVRQVREMEAELEDERKQRSMA 1608
Query: 127 MVSNAQLDNEKNNLIYQVDT------------------LKDVIEEQEEQMA---EFYREN 165
+ + +L+ + +L +D+ +KD + E ++ A E +
Sbjct: 1609 VAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQA 1668
Query: 166 EEKSKELERQKHMCSVLQHKMEELKEGLRQ----RDELIEKHGLVIIPDGTPNGDVSHEP 221
+E K+L+ + LQ ++ + RQ RDEL ++ I + + G ++ E
Sbjct: 1669 KENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADE-----IANSSGKGALALEE 1723
Query: 222 VAGAITVVSQEAAQVLESAGEGPL-----------------DVRLRKLAGEKEELLSQIR 264
++Q ++ E G L D+ L + +K E Q
Sbjct: 1724 KRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQ-- 1781
Query: 265 KLKLQLEEERQKCSRNDGTV------------GDLAGLQNGSDLQFIEMQ---RDANRQI 309
+L+ Q +E + K +GTV +A L+ D + E Q + R
Sbjct: 1782 QLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTE 1841
Query: 310 SEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELK---AEKRKLQRELR 366
+ K L + + + EQ + + R K E+ E+E + A +RKLQREL
Sbjct: 1842 KKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELE 1901
Query: 367 TALDKIEEMEMTNSHLAKRLEK 388
A + + M S L +L +
Sbjct: 1902 DATETADAMNREVSSLKNKLRR 1923
Score = 47.0 bits (110), Expect = 3e-05
Identities = 96/436 (22%), Positives = 170/436 (38%), Gaps = 78/436 (17%)
Query: 38 KRAARAEARDIRMRELERQQKELDEKSDKQYAE--NYT---RPSSRNSASATTPLSGNSS 92
K A+ + ++ E ER + EL +K K E N T S S+ T S S
Sbjct: 1249 KVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALES 1308
Query: 93 RRGSGDTSSLIDPDTSLS-ELRESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVI 151
+ DT L+ + L L +VE++ + + K+NL Q+ TL +
Sbjct: 1309 QLQ--DTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQV 1366
Query: 152 EEQEEQM---------AEFYRENEEKSKELERQKHMCSVLQH-KMEELKEGLRQR-DELI 200
+ +++M AE + +K E Q+H V + K+E+ K L+Q D+L+
Sbjct: 1367 ADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLL 1426
Query: 201 -----------------EKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEA-----AQVLE 238
+K ++ + T + + E +E A+ LE
Sbjct: 1427 VDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALE 1486
Query: 239 SAGEGPLDV-RLRK-LAGEKEELLS---------------------QIRKLKLQLEE-ER 274
A E ++ RL K E E+L+S Q+ ++K QLEE E
Sbjct: 1487 EAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELED 1546
Query: 275 QKCSRNDGTVGDLAGLQ----------NGSDLQFIEMQRDANRQISEYKFKLSKAEQDIT 324
+ + D + LQ G D Q E ++ RQ+ E + +L + +
Sbjct: 1547 ELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRS 1606
Query: 325 TLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAK 384
+ +LE + + ++A K DE + RKLQ +++ D + E++ T + +
Sbjct: 1607 MAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMK---DCMRELDDTRASREE 1663
Query: 385 RLEKMKANRTALLAQQ 400
L + K N L + +
Sbjct: 1664 ILAQAKENEKKLKSME 1679
Score = 46.6 bits (109), Expect = 4e-05
Identities = 68/347 (19%), Positives = 139/347 (40%), Gaps = 48/347 (13%)
Query: 53 LERQQKELDE--KSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLS 110
LE++QK+ D+ +K + Y R A A R SL +L
Sbjct: 1439 LEKKQKKFDQLLAEEKTISAKYAEERDRAEAEA---------REKETKALSLA---RALE 1486
Query: 111 ELRESLSEVEEKYKKAMVSNAQLDNEKNNL---IYQVDTLKDVIEEQEEQMAEFYRENEE 167
E E +E+E K+ L + K+++ +++++ K +E+Q E+M E E+
Sbjct: 1487 EAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELED 1546
Query: 168 KSKELERQKHMCSV-LQHKMEELKEGLRQRDELI-EKHGLVIIPDGTPNGDVSHEPVAGA 225
+ + E K V LQ + + L+ RDE EK ++ ++ E +
Sbjct: 1547 ELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRS 1606
Query: 226 ITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVG 285
+ V +++ ++ L+ + ++E + Q+RKL+ Q+++ C R
Sbjct: 1607 MAVAARKKLEM----DLKDLEAHIDSANKNRDEAIKQLRKLQAQMKD----CMRE----- 1653
Query: 286 DLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAE 345
D E + + E+ + ++E + +L+ ++ + A
Sbjct: 1654 ----------------LDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKR 1697
Query: 346 NAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKAN 392
A++ DEL E + AL++ +E + L + LE+ + N
Sbjct: 1698 QAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGN 1744
Score = 37.7 bits (86), Expect = 0.019
Identities = 64/312 (20%), Positives = 126/312 (40%), Gaps = 49/312 (15%)
Query: 24 LSNIAREAEARLAAKRAARAEARDIRMRELERQQKELDEKSDKQYAENYTRPSSRNSASA 83
+ + RE + A++ A+A++ ++L+ + E+ + ++ A + ++
Sbjct: 1647 MKDCMRELDDTRASREEILAQAKE-NEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDE 1705
Query: 84 TTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSE-------VEEKYKKAMVSNAQLDNE 136
NSS +G+ + +++L E L E + ++ KKA N Q+D
Sbjct: 1706 LADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKA---NLQIDQI 1762
Query: 137 KNNLIYQVDTLKDVIEEQEEQMAEFYRENEE---KSKELE---RQKHMCSV--LQHKMEE 188
+L + + ++ E + R+N+E K +E+E + K+ S+ L+ K+ +
Sbjct: 1763 NTDLNLE----RSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQ 1818
Query: 189 LKEGLR-------------QRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQ 235
L+E L +R E K L+ + D N + + A T + Q Q
Sbjct: 1819 LEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQ 1878
Query: 236 VLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSD 295
LE A E E + + RKL+ +LE+ + + V L D
Sbjct: 1879 -LEEAEE------------EAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRRGD 1925
Query: 296 LQFIEMQRDANR 307
L F+ +R A +
Sbjct: 1926 LPFVVPRRMARK 1937
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 62.4 bits (150), Expect = 7e-10
Identities = 89/408 (21%), Positives = 162/408 (39%), Gaps = 64/408 (15%)
Query: 12 PVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKELD--------EK 63
P +++ + L + EA A + +AR + M E ER Q+E E+
Sbjct: 401 PPQEKGEVLGDVLQLETLKQEAATLAANNTQLQAR-VEMLETERGQQEAKLLAERGHFEE 459
Query: 64 SDKQYAENYT--RPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSEVEE 121
+Q + T + S N + A L S G+ T+ + + L+ L ++ + ++
Sbjct: 460 EKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQ 519
Query: 122 ---------KYKKAMVSNA--QLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSK 170
K K+A ++ Q + L +QV+ L ++++E+Q+ E + +
Sbjct: 520 ELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEV-----AEKQ 574
Query: 171 ELERQKHMCSVLQHKMEELKEGLRQRD------ELIEKHG---LVIIPDGTPNGDVSHEP 221
E RQ H L EE + LR+RD E +EK L I+ + + +
Sbjct: 575 EATRQDH-AQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDS 633
Query: 222 VAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRND 281
++T +E A++ E L + E+ E +Q+ +L+LQL E+QK + +
Sbjct: 634 AQTSVTQAQREKAELSRKVEE--LQACVETARQEQHEAQAQVAELELQLRSEQQKATEKE 691
Query: 282 GTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYK 341
+ LQ Q + K++K LE + R
Sbjct: 692 RVAQEKDQLQE-------------QLQALKESLKVTKGS------------LEEEKRRAA 726
Query: 342 TAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKM 389
A E ++ ELKAE R L + + ++EE L RL+++
Sbjct: 727 DALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQL 774
Score = 58.9 bits (141), Expect = 8e-09
Identities = 80/372 (21%), Positives = 158/372 (42%), Gaps = 23/372 (6%)
Query: 34 RLAAKRAARAEARDIRMRELERQQKELDEKSDKQYA---ENYTRPSSRNSASATTPLSGN 90
RL + A RD EL +K L EK D Q A + R + N A +PL
Sbjct: 218 RLKKQLADERSNRDELELELAENRKLLTEK-DAQIAMMQQRIDRLALLNEKQAASPLEPK 276
Query: 91 SSR----RGSGDTSSLIDPDTSLSELRESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDT 146
+ T L + +L+ S+++ K + N L + +
Sbjct: 277 ELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQ 336
Query: 147 LKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHK--MEELKEGLRQRDELIEKHG 204
L+D + E E+ ++ +E EK +LE K + + LQ K +EE E L+ + +E+H
Sbjct: 337 LQDALNELTEEHSKATQEWLEKQAQLE--KELSAALQDKKCLEEKNEILQGKLSQLEEH- 393
Query: 205 LVIIPDGTP--NGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQ 262
L + D P G+V + + + + QEAA + +A L R+ L E+ + ++
Sbjct: 394 LSQLQDNPPQEKGEVLGDVL--QLETLKQEAATL--AANNTQLQARVEMLETERGQQEAK 449
Query: 263 IRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQD 322
+ + EEE+Q+ S + DL + E+++ + + +++ +
Sbjct: 450 LLAERGHFEEEKQQLS---SLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSE 506
Query: 323 ITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKI-EEMEMTNSH 381
+TTL +I + + ++ K A+ + + ++ + + LR ++++ ++
Sbjct: 507 LTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQ 566
Query: 382 LAKRLEKMKANR 393
L + EK +A R
Sbjct: 567 LKEVAEKQEATR 578
Score = 58.9 bits (141), Expect = 8e-09
Identities = 91/399 (22%), Positives = 164/399 (41%), Gaps = 59/399 (14%)
Query: 10 RTPVKDRFSAEDEALSNIAR---EAEARLAAKRAARAEARDIRMRELER--QQKELD--- 61
RT V+D AEDE + +AR EAE + + + E + + LE+ + KEL
Sbjct: 1196 RTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLV 1255
Query: 62 --EKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSEV 119
E Q E R +AS +S R + +S+L + SL E E
Sbjct: 1256 MAESEKSQKLEERLRLLQAETAS--------NSARAAERSSALREEVQSLREEAEKQRVA 1307
Query: 120 EEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKS---KELERQK 176
E ++ + S A+ E L ++ ++ ++E+ ++ E+ EL K
Sbjct: 1308 SENLRQELTSQAERAEE---LGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAK 1364
Query: 177 HMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQV 236
H+C LQ E+ R R+EL + + AG + A++
Sbjct: 1365 HLCQQLQ--AEQAAAEKRHREELEQS-----------------KQAAGGL------RAEL 1399
Query: 237 LESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVG-DLAGLQNGSD 295
L + E + LR+ E+E Q+R K E+ + G + + GL ++
Sbjct: 1400 LRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERAN 1459
Query: 296 L--QFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISR---LEGQVLRYKTAAENAEKV 350
L QF+E++ D R+ +Y +L+ D T + R + L TA KV
Sbjct: 1460 LGRQFLEVELDQARE--KYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKV 1517
Query: 351 EDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKM 389
++ E+++ Q E + ++E++E+ K++E++
Sbjct: 1518 --KVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEEL 1554
Score = 47.8 bits (112), Expect = 2e-05
Identities = 88/412 (21%), Positives = 157/412 (38%), Gaps = 46/412 (11%)
Query: 15 DRFSAEDEALSNIAREAEARLAAKRAARAE--ARDIRMRELERQQKELDEKSDKQYAENY 72
+R SA E + ++ EAE + A R E ++ R EL ++ K EK ++
Sbjct: 1285 ERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALS 1344
Query: 73 TRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSEVEEKYKKAMVSNAQ 132
T S A S + + + + +E R E+E+ + A A+
Sbjct: 1345 TLQLEHTSTQALV-----SELLPAKHLCQQLQAEQAAAEKRHR-EELEQSKQAAGGLRAE 1398
Query: 133 LDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEG 192
L + L ++ L+ + EQE + E +++L K +L + L E
Sbjct: 1399 LLRAQREL-GELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGER 1457
Query: 193 L------------RQRDELIEKHGLVIIPDGTPNGDVSHEPVAGA----ITVVSQEAAQV 236
+ R++ +++ V T +V E + A + E A+V
Sbjct: 1458 ANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKV 1517
Query: 237 LESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDL 296
+KL + E+L R+ Q+EE +K + +D
Sbjct: 1518 KVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQA 1577
Query: 297 QFIEMQRDANR----------QISE-------YKFKLSKAEQDITTLEQSISRLEGQVLR 339
Q E Q++A R Q+S+ YK ++ KA+ +Q L+ Q+
Sbjct: 1578 QGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQL-- 1635
Query: 340 YKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKA 391
+ E +K EL+AE +L EL+ A K +E E T HL ++ ++A
Sbjct: 1636 --RSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEA 1685
Score = 43.5 bits (101), Expect = 3e-04
Identities = 84/394 (21%), Positives = 154/394 (39%), Gaps = 65/394 (16%)
Query: 15 DRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMREL--------ERQQKELDEKSDK 66
D S E ++ ++E ARL E ++ REL +RQ + L+E+ +
Sbjct: 900 DDLSTLQEKMAATSKEV-ARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGR 958
Query: 67 QYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELR-ESLSEVEEKYKK 125
Q+ ++ + GN R ++L++ E R + EV ++
Sbjct: 959 QFCSTQ---AALQAMEREAEQMGNELERLR---AALMESQGQQQEERGQQEREVARLTQE 1012
Query: 126 AMVSNAQLDNEKNNLIYQVDTLKDVIEEQ-------EEQMAEFYRENEEKSKELERQKHM 178
+ A L EK L++ + EQ +E +A E E K +EL + + +
Sbjct: 1013 RGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGL 1072
Query: 179 CSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLE 238
+ ++EEL++ ++Q E + K + H +GA EAA E
Sbjct: 1073 EAAQIKELEELRQTVKQLKEQLAKK------------EKEHASGSGA----QSEAAGRTE 1116
Query: 239 SAGEG--PLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDL 296
G L + KL + ++ Q L+ LE ER + D + L G
Sbjct: 1117 PTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQ 1176
Query: 297 QFIEMQR---DANRQISEYKFKL---SKAEQD------------------ITTLEQSISR 332
+ Q A R+++ ++ K+ SKAE + I++LE+ +S
Sbjct: 1177 ELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSI 1236
Query: 333 LEGQVLRYKTAAENAEKVEDELKAEKRKLQRELR 366
L QVL + ++ +++ + +KL+ LR
Sbjct: 1237 LNRQVLEKEGESKELKRLVMAESEKSQKLEERLR 1270
Score = 34.3 bits (77), Expect = 0.20
Identities = 41/196 (20%), Positives = 73/196 (37%), Gaps = 16/196 (8%)
Query: 10 RTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQK---------EL 60
R + R + + ARE E A A+ + + R R E +QK
Sbjct: 1484 RADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVF 1543
Query: 61 DEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDP-DTSLSELRESLSEV 119
+ KQ E + + + AS + + G++ L+EL+ LS+
Sbjct: 1544 QREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQ- 1602
Query: 120 EEKYKKAMVSNAQLDNEKNNLIYQVDTLKD-VIEEQEEQMAEFYRENEEKSKELERQKHM 178
K+ + +L EK Y ++ ++EQ + + +EN+E E ER H
Sbjct: 1603 ----KEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHE 1658
Query: 179 CSVLQHKMEELKEGLR 194
K +E ++ R
Sbjct: 1659 LQQAGLKTKEAEQTCR 1674
Score = 33.1 bits (74), Expect = 0.46
Identities = 30/129 (23%), Positives = 59/129 (45%), Gaps = 28/129 (21%)
Query: 262 QIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQ 321
Q+R+LK QL +ER S+ +E++ NR++ L++ +
Sbjct: 215 QMRRLKKQLADER-------------------SNRDELELELAENRKL------LTEKDA 249
Query: 322 DITTLEQSISRLEGQVLRYKTAAENAEKVE-DELKAEKRKLQRELRTALDKIEEMEMTNS 380
I ++Q I RL +L K AA E E +EL+ + L L L + ++++ S
Sbjct: 250 QIAMMQQRIDRL--ALLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKS 307
Query: 381 HLAKRLEKM 389
+ +++ ++
Sbjct: 308 QMDRKINQL 316
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 61.6 bits (148), Expect = 1e-09
Identities = 98/406 (24%), Positives = 175/406 (43%), Gaps = 71/406 (17%)
Query: 22 EALSNIAREAEARLAAKRAARAE-------ARDIRMRELERQQKELDEKSDKQYAENYTR 74
+ L REA+A L +RAA E ++ RELE ++ +L + ++ E R
Sbjct: 971 QKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLAR 1030
Query: 75 PSSRNSASATTPLSGNSSRRGSG---------DTSSLIDPD-TSLSE----LRESLS--- 117
+ + ++ R G SL + + T+LSE R SL+
Sbjct: 1031 LEAEKE-ELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATIS 1089
Query: 118 -EVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQK 176
E+E + + A Q + N L ++ L+ EE A+ R +E++++L +Q+
Sbjct: 1090 LEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQR 1149
Query: 177 HMC-------SVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVV 229
C +E+ ++GLR+ EL+E + E G V
Sbjct: 1150 DSCLREAEELRTQLRLLEDARDGLRR--ELLEAQRKL------------RESQEGR-EVQ 1194
Query: 230 SQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRK-------LKLQLEEERQKCSRND- 281
QEA ++ S GEG + L EEL S ++K LKL E++ QK + +
Sbjct: 1195 RQEAGELRRSLGEGAKE--REALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEE 1252
Query: 282 --GTVGDLAG-LQNGSDLQFIEMQR-DANRQISEYKFKLSKAEQDITTLEQSISRLEGQV 337
VG AG L+ G LQ +E R +A R++ E + ++ + + T L + ++ L+G++
Sbjct: 1253 ARTAVGKEAGELRTG--LQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRL 1310
Query: 338 LRYKTAAENAEKVEDELK-------AEKRKLQRELRTALDKIEEME 376
+ A + + + L+ A +++EL+ A K++E E
Sbjct: 1311 ALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQE 1356
Score = 53.5 bits (127), Expect = 3e-07
Identities = 70/304 (23%), Positives = 127/304 (41%), Gaps = 39/304 (12%)
Query: 110 SELRESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKS 169
S L SL +++ ++ +L + L Q D L++ E+ + A RE E
Sbjct: 606 SNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSH 665
Query: 170 KELERQKHMCSVLQHKMEELKEGLR----QRDELIEKHGLVIIPDGTPNGDVSHEPVAGA 225
++LE+ + SVL ++ E++E L QRD L +V+
Sbjct: 666 RQLEQLEGKRSVLAKELVEVREALSRATLQRDML-----------QAEKAEVAEALTKAE 714
Query: 226 ITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLS---QIRKLKLQLEEE------RQK 276
V E + A E L L KL+ E L + +L QLEEE RQ+
Sbjct: 715 AGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQR 774
Query: 277 CSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSK-----AEQDITTLEQSIS 331
+ + TV + L+ + ++++ RQ E ++++ EQ + TL S
Sbjct: 775 QAEQEATV----AREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERS 830
Query: 332 RLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKI--EEMEMTNSHLAKRLEKM 389
+L+ Q+ + E+ EL+ +R+ QR++ AL++ E+ + H ++ +
Sbjct: 831 QLQEQLAQLSRQLSGREQ---ELEQARREAQRQVE-ALERAAREKEALAKEHAGLAVQLV 886
Query: 390 KANR 393
A R
Sbjct: 887 AAER 890
Score = 53.1 bits (126), Expect = 4e-07
Identities = 82/369 (22%), Positives = 155/369 (42%), Gaps = 64/369 (17%)
Query: 84 TTPLSGNSSRRGSG----DTSSLIDPDTSLSELRESLSEVEEKYKKAMVSNAQL------ 133
++P G S RRG D+S+L ++L + + + ++ +Y+ + L
Sbjct: 499 SSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSD 558
Query: 134 -DNEKNNLIYQVDTLKDVI-------EEQEEQMAEFYRENEEKSKELERQKHMCSVLQHK 185
++E+ L Q+ L+D E+ + ++ NE S+E H V Q +
Sbjct: 559 SESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQ 618
Query: 186 MEELK----------EGLRQRDELIEKHGLVIIPDGT---PNGDVSH---EPVAGAITVV 229
EEL+ E LR++ + +E+ + DG + SH E + G +V+
Sbjct: 619 AEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVL 678
Query: 230 SQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKL---KLQLEEERQKCSRNDGTVGD 286
++E +V E+ L + L EK E+ + K +++LE K + ++ D
Sbjct: 679 AKELVEVREALSRATLQRDM--LQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQD 736
Query: 287 LAGLQNGSDLQFIEMQRDANR---QISEYKFKLS----KAEQDITT------------LE 327
+ + + + D NR Q+ E K L +AEQ+ T LE
Sbjct: 737 SLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLE 796
Query: 328 QSISR--LEGQVLRYKTAAENAEKVEDELKAEKRKLQREL----RTALDKIEEMEMTNSH 381
Q ++R LEG + + A E E+ L+ E+ +LQ +L R + +E+E
Sbjct: 797 QEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARRE 856
Query: 382 LAKRLEKMK 390
+++E ++
Sbjct: 857 AQRQVEALE 865
Score = 46.2 bits (108), Expect = 5e-05
Identities = 89/422 (21%), Positives = 159/422 (37%), Gaps = 70/422 (16%)
Query: 4 PASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKELDEK 63
P+ G +P + EA+ RE L + + R E R + L RQ E++ +
Sbjct: 1489 PSPGPATSPASP--DLDPEAVRGALREFLQELRSAQRERDELRT-QTSALNRQLAEMEAE 1545
Query: 64 SD----------KQYAENYTRPSS----RNSASATTPLSGNSSRRGSGDTSSLIDP---- 105
D K AE+ S + A L S RR + + +D
Sbjct: 1546 RDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATL 1605
Query: 106 DTSLSELRESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYREN 165
+ SL L +EK K + +L+ +K L K+V++ E + + +
Sbjct: 1606 ERSLQATESELRASQEKISKMKANETKLEGDKRRL-------KEVLDASESRTVKLELQR 1658
Query: 166 EEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGA 225
EL+R + S + + + L++ + D L + + GT V E + GA
Sbjct: 1659 RSLEGELQRSRLGLSDREAQAQALQDRV---DSLQRQVADSEVKAGTLQLTV--ERLNGA 1713
Query: 226 ITVVSQEAAQVLESAGEGPLDVRLRKLA---GEKEELLSQIRKLKLQLEEERQKCSRNDG 282
+ V + EG L ++R L + L+ R L L++ C
Sbjct: 1714 LAKVEES---------EGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEH--- 1761
Query: 283 TVGDLAGLQNGSDLQFIEMQRDANRQ-ISEYKFKLSKAEQDITTLEQSISRLE------- 334
D Q ++ + DA RQ +SE + + S + + TL ++ LE
Sbjct: 1762 ------------DRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAE 1809
Query: 335 GQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRT 394
GQ+ + + ++ E +KLQ E R +++ ++ + L EK + R+
Sbjct: 1810 GQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQL--EAEKREVERS 1867
Query: 395 AL 396
AL
Sbjct: 1868 AL 1869
Score = 40.4 bits (93), Expect = 0.003
Identities = 24/95 (25%), Positives = 53/95 (55%), Gaps = 7/95 (7%)
Query: 297 QFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEK--VEDEL 354
Q +E++R + + Y+ KL ++ Q + RL+G++L+YK E+ +E
Sbjct: 140 QSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLERSG 199
Query: 355 KAEKRKLQ-----RELRTALDKIEEMEMTNSHLAK 384
+ E+++L+ ++L +AL ++EE + ++ LA+
Sbjct: 200 ELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQ 234
Score = 37.0 bits (84), Expect = 0.032
Identities = 71/310 (22%), Positives = 122/310 (39%), Gaps = 40/310 (12%)
Query: 29 REAEARLAAKRAARAEARDIRMRELERQQKELDEKSDKQYAENYTRPSSRNSASATTPLS 88
REAE L + +ARD REL Q++L E + + + R S
Sbjct: 1154 REAE-ELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAK-E 1211
Query: 89 GNSSRRGSGDTSSLIDPDTSLSELRESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLK 148
+ RR + + S + S + L+ +++ K A++ A+ K + L+
Sbjct: 1212 REALRRSNEELRSAVKKAES-ERISLKLANEDKEQKLALLEEARTAVGK-----EAGELR 1265
Query: 149 DVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKE--GLRQRDELIEKHGLV 206
++E E E RE +E ++++ + L ++ EL+ L +R E + +
Sbjct: 1266 TGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETL 1325
Query: 207 IIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKL 266
+ G+ S E V+ QE L V RKL ++ E ++ R+L
Sbjct: 1326 GLRQRLLKGEASLE-------VMRQE------------LQVAQRKLQEQEGEFRTRERRL 1366
Query: 267 KLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTL 326
LEE R GT G +L+ A + +E +LS AE L
Sbjct: 1367 LGSLEEAR-------GTEKQQLDHARGLELKL----EAARAEAAELGLRLSAAEGRAQGL 1415
Query: 327 EQSISRLEGQ 336
E ++R+E Q
Sbjct: 1416 EAELARVEVQ 1425
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 61.2 bits (147), Expect = 2e-09
Identities = 75/366 (20%), Positives = 152/366 (41%), Gaps = 40/366 (10%)
Query: 24 LSNIAREAEARLAAKRAARAEARDIRMRELERQQKELDEKSDKQYAENYTRPSSRNS-AS 82
L + EA +AA R A++ +++ Q+ + +K +K+ +E +S A
Sbjct: 1181 LEEATLQHEAMVAALRKKHADSMAELGEQIDNLQR-VKQKLEKEKSELKMETDDLSSNAE 1239
Query: 83 ATTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSEVEEKYKKAMVS----NAQLDNEKN 138
A + GN + + + T E + ++++ + + + QLD EK+
Sbjct: 1240 AISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLD-EKD 1298
Query: 139 NLIYQVDTLKDV----IEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLR 194
L+ Q+ K IEE + Q+ E + + L+ +H C +L+ + EE +EG
Sbjct: 1299 ALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKA 1358
Query: 195 QRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEA----AQVLESAGEG--PLDVR 248
+ + K + T +E A T +EA AQ L+ A E ++ +
Sbjct: 1359 ELQRALSKANSEVAQWRT-----KYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAK 1413
Query: 249 LRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQ 308
L K+ L +++ L L +E C+ D + QR+ ++
Sbjct: 1414 CASLEKTKQRLQNEVEDLMLDVERSNAACAALD------------------KKQRNFDKV 1455
Query: 309 ISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTA 368
+SE+K K + + ++ ++ L ++ + K E + + L+ E + LQ+E+
Sbjct: 1456 LSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDL 1515
Query: 369 LDKIEE 374
++I E
Sbjct: 1516 TEQIAE 1521
Score = 55.8 bits (133), Expect = 7e-08
Identities = 57/260 (21%), Positives = 122/260 (46%), Gaps = 17/260 (6%)
Query: 143 QVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEK 202
++ T+K+ ++ ++++A+ +E K KELE + M ++L+ K + + + D L +
Sbjct: 851 EMATMKEEFQKTKDELAK----SEAKRKELEEK--MVTLLKEKNDLQLQVQSEADSLADA 904
Query: 203 HGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQ 262
+ + E +T ++E ++ L + RKL E EL
Sbjct: 905 EERC---EQLIKNKIQLEAKIKEVTERAEEEEEI-----NAELTAKKRKLEDECSELKKD 956
Query: 263 IRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLS--KAE 320
I L+L L + ++ + V +L G D ++ ++ ++ L +AE
Sbjct: 957 IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAE 1016
Query: 321 QD-ITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTN 379
+D + L ++ ++LE QV + + E +K+ +L+ KRKL+ +L+ A + +ME
Sbjct: 1017 EDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDK 1076
Query: 380 SHLAKRLEKMKANRTALLAQ 399
L ++LEK + + L+++
Sbjct: 1077 QQLDEKLEKKEFEISNLISK 1096
Score = 48.1 bits (113), Expect = 1e-05
Identities = 83/421 (19%), Positives = 171/421 (40%), Gaps = 57/421 (13%)
Query: 13 VKDRFSAEDEALSNIAR---EAEARLAAKRAARAEARDIRMRELERQQKELDEKSDKQYA 69
+++++ E E + + R +A + +A R R ELE +K+L ++ Q A
Sbjct: 1346 LREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRL--QEA 1403
Query: 70 ENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLS----------ELRESLSEV 119
E + + AS L R + ++D + S + + LSE
Sbjct: 1404 EEHVEAVNAKCAS----LEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEW 1459
Query: 120 EEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYREN---EEKSKELERQK 176
++KY++ E +L ++ +K+V EE +Q+ REN +++ +L Q
Sbjct: 1460 KQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQI 1519
Query: 177 HMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQV 236
H++E++K+ + Q E E I + S E G I + E QV
Sbjct: 1520 AEGGKQIHELEKIKKQVEQ--EKCE------IQAALEEAEASLEHEEGKILRIQLELNQV 1571
Query: 237 LESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKC------SRNDG------TV 284
RK+A EK+E + Q+++ ++ E Q SRND
Sbjct: 1572 KSEVD--------RKIA-EKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKME 1622
Query: 285 GDLAGLQ------NGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVL 338
GDL ++ N + + R+ + E + L A + L++ ++ +E +
Sbjct: 1623 GDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRAN 1682
Query: 339 RYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLA 398
+ E ++ + ++ ++EL A ++++ + N+ L +K++ + + L +
Sbjct: 1683 LLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQS 1742
Query: 399 Q 399
+
Sbjct: 1743 E 1743
Score = 47.4 bits (111), Expect = 2e-05
Identities = 59/300 (19%), Positives = 123/300 (41%), Gaps = 29/300 (9%)
Query: 111 ELRESLSEVEEKYKKAMVSNAQLDNEK--------------NNLIYQVDTLKDVIEEQEE 156
+L + ++E K A S ++N+K +NLI +++ + V + ++
Sbjct: 1050 DLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQK 1109
Query: 157 QMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGD 216
++ E EE +E+E ++ + + + +L L + E +E+ G G +
Sbjct: 1110 KIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAG------GATSAQ 1163
Query: 217 VSHEPVAGAITVVSQEAAQVLESAG---EGPLDVRLRKLAGEKEELLSQI---RKLKLQL 270
V A Q+ + LE A E + +K A EL QI +++K +L
Sbjct: 1164 VELNKKREA---EFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKL 1220
Query: 271 EEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSI 330
E+E+ + + A + + +M R Q+SE K K + ++ I L
Sbjct: 1221 EKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQR 1280
Query: 331 SRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMK 390
+RL+ + Y + + + +L K+ +++ ++EE + LA L+ +
Sbjct: 1281 ARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSR 1340
Score = 46.6 bits (109), Expect = 4e-05
Identities = 82/417 (19%), Positives = 166/417 (39%), Gaps = 41/417 (9%)
Query: 13 VKDRFSAEDEALSNIAREAEARLAAKRAA----RAEARDIRMRELERQQKELDEKSDKQY 68
+K + E + EAEA L + + E ++ E++R+ E DE+ D Q
Sbjct: 1532 IKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKS-EVDRKIAEKDEEID-QL 1589
Query: 69 AENYTR--PSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSEVEEKYKKA 126
N+TR + +++ A ++ R L + + L+ +E Y+
Sbjct: 1590 KRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNT 1649
Query: 127 MVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKM 186
+ ++ + + LK+ + E + E EE LE+ + + + ++
Sbjct: 1650 QGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQEL 1709
Query: 187 EELKEGLRQRDELIEKHGLVIIPDGTP-NGDVSHEPVAGAITVVSQEAAQVLESAGEGPL 245
+ E R +L+ +I DVS + + V QE+ E A +
Sbjct: 1710 LDASE----RVQLLHTQNTSLINTKKKLENDVSQ--LQSEVEEVIQESRNAEEKAKKAIT 1763
Query: 246 DV-----RLRK-------LAGEKEELLSQIRKLKLQLEEERQ--------KCSRNDGTVG 285
D L+K L K+ L ++ L+ +L+E Q + + + V
Sbjct: 1764 DAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVR 1823
Query: 286 DLAGL---QNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKT 342
+L G + + + ++ R R++ E ++ + +++ L+ + +L+ +V YK
Sbjct: 1824 ELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKR 1883
Query: 343 AAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQ 399
AE AE+ + ++ RKLQ EL A E ++ S + K K + T + A+
Sbjct: 1884 QAEEAEEQSNANLSKFRKLQHELEEA---EERADIAESQVNKLRVKSREVHTKISAE 1937
Score = 45.1 bits (105), Expect = 1e-04
Identities = 56/297 (18%), Positives = 139/297 (46%), Gaps = 27/297 (9%)
Query: 103 IDPDTSLSELRESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTL---KDVIEEQEEQMA 159
I P +E + ++ ++E+++K A+ + ++ L ++ TL K+ ++ Q + A
Sbjct: 839 IKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEA 898
Query: 160 EFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDEL-----IEKHGLVIIPDGTPN 214
+ + EE+ ++L + K L+ K++E+ E + +E+ +K L D
Sbjct: 899 DSLADAEERCEQLIKNKIQ---LEAKIKEVTERAEEEEEINAELTAKKRKL---EDECSE 952
Query: 215 GDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEER 274
+ + + V +E + A E + ++AG +E ++++ K K L+E
Sbjct: 953 LKKDIDDLELTLAKVEKE-----KHATENKVKNLTEEMAG-LDETIAKLSKEKKALQETH 1006
Query: 275 QKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLE 334
Q+ T+ DL ++ ++ + + +Q+ + + L + ++ LE++ +LE
Sbjct: 1007 QQ------TLDDLQAEEDKVNI-LTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLE 1059
Query: 335 GQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKA 391
G + + + + E + +L + K + E+ + KIE+ + L K++++++A
Sbjct: 1060 GDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQA 1116
Score = 43.9 bits (102), Expect = 3e-04
Identities = 79/364 (21%), Positives = 147/364 (40%), Gaps = 78/364 (21%)
Query: 30 EAEARLAAKRAARAEARDIRMRELERQQKELDEKSDKQYAENYTRPSSRNSASATTPLSG 89
E E +A + + +D + + E ++KEL+EK T +N
Sbjct: 847 ETEKEMATMKEEFQKTKD-ELAKSEAKRKELEEKM-------VTLLKEKNDLQLQVQSEA 898
Query: 90 NSSRRGSGDTSSLIDPDTSLSELRESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKD 149
+S LI + +L + EV E+ ++ NA+L +K L + LK
Sbjct: 899 DSLADAEERCEQLIK---NKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKK 955
Query: 150 VIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIP 209
I++ E +A+ +E++KH ++K++ L E + DE I K +
Sbjct: 956 DIDDLELTLAK-----------VEKEKH---ATENKVKNLTEEMAGLDETIAK-----LS 996
Query: 210 DGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQ 269
+H+ + ++ +L A +L + + E L Q +KL++
Sbjct: 997 KEKKALQETHQQTLDDLQA-EEDKVNILTKA-----KTKLEQQVDDLEGSLEQEKKLRMD 1050
Query: 270 LEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQS 329
LE ++K GDL Q + ++M+ D +Q+ E KL K E +I+ L
Sbjct: 1051 LERAKRKLE------GDLKLAQEST----MDMEND-KQQLDE---KLEKKEFEISNL--- 1093
Query: 330 ISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKM 389
K+EDE +A + +LQ++++ +IEE L + +E
Sbjct: 1094 -----------------ISKIEDE-QAVEIQLQKKIKELQARIEE-------LGEEIEAE 1128
Query: 390 KANR 393
+A+R
Sbjct: 1129 RASR 1132
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 60.8 bits (146), Expect = 2e-09
Identities = 58/305 (19%), Positives = 122/305 (40%), Gaps = 37/305 (12%)
Query: 106 DTSLSELRESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYREN 165
+ LSE R E++ + ++L E L Q++ + ++ + F ++
Sbjct: 1254 EDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQT 1313
Query: 166 EEKSKELERQ--------------KHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDG 211
EE ++LE + +H C +L+ + EE +EG + + K
Sbjct: 1314 EELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSK--------- 1364
Query: 212 TPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLE 271
++ VA T +A Q E L+ +KLA ++ Q+ + +
Sbjct: 1365 ------ANSEVAQWRTKYETDAIQRTEE-----LEEAKKKLAQRLQDSEEQVEAVNAKCA 1413
Query: 272 EERQKCSRNDGTVGDL---AGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQ 328
+ R G V DL N + QR+ ++ ++E+K K +++ ++ +
Sbjct: 1414 SLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLK 1473
Query: 329 SISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEK 388
L ++ + K A E A + +K E + L++E+ ++I E T L K ++
Sbjct: 1474 ESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQ 1533
Query: 389 MKANR 393
++ +
Sbjct: 1534 IELEK 1538
Score = 60.5 bits (145), Expect = 3e-09
Identities = 64/268 (23%), Positives = 123/268 (45%), Gaps = 26/268 (9%)
Query: 125 KAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSV-LQ 183
K ++ +A+ + E + + KD + + E + E EEK L ++K+ + +Q
Sbjct: 838 KPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKEL----EEKLVTLVQEKNDLQLQVQ 893
Query: 184 HKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEG 243
+ E L + + D+LI+ + + I V++ A E E
Sbjct: 894 AESENLLDAEERCDQLIK----------------AKFQLEAKIKEVTERAEDEEEINAE- 936
Query: 244 PLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQR 303
L + RKL E EL I L+L L + ++ + V +L +G D ++ R
Sbjct: 937 -LTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTR 995
Query: 304 DANRQISEYKFKLS--KAEQD-ITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRK 360
+ ++ L +AE+D + +L ++ S+LE QV +++ E +K+ +L+ KRK
Sbjct: 996 EKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRK 1055
Query: 361 LQRELRTALDKIEEMEMTNSHLAKRLEK 388
L+ +L+ A + I ++E L +RL+K
Sbjct: 1056 LEGDLKLAQESILDLENDKQQLDERLKK 1083
Score = 50.1 bits (118), Expect = 4e-06
Identities = 84/409 (20%), Positives = 174/409 (42%), Gaps = 68/409 (16%)
Query: 25 SNIAREAEARLAAKRAARAEARDIRMRE-----LERQQKELDEKSDKQYAENYTRPSSRN 79
S++ +E + R+ +R R D+++ + LE +++LDE+ K+ E Y + S+
Sbjct: 1037 SSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFE-YCQLQSKV 1095
Query: 80 SASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSEVEEKYKKAMVSNAQLDNEKNN 139
T L + EL+ + E+EE+ + + A+ + ++++
Sbjct: 1096 EDEQTLGLQFQKK----------------IKELQARIEELEEEIEAERATRAKTEKQRSD 1139
Query: 140 LIYQVDTLKDVIEE--------------QEEQMAEFYRENEEKSKELE------RQKHMC 179
+++ L + +EE +E + + R+ EE + + E R+KH
Sbjct: 1140 YARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHAD 1199
Query: 180 SVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLES 239
SV + + E + L++ + +EK + + ++ ++ VS+ A + +
Sbjct: 1200 SVAE--LGEQIDNLQRVKQKLEKE--------KSEFKLEIDDLSSSMESVSKSKANLEKI 1249
Query: 240 AGEGPLDVRLRKLAGEKEEL---LSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDL 296
L+ +L + G+ EE+ LS++ K +L+ E + SR + + S
Sbjct: 1250 CRT--LEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQ 1307
Query: 297 QFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKA 356
F + + RQ+ E +KA+ + QS SR + +LR + E K E +
Sbjct: 1308 AFTQQTEELKRQLEEE----NKAKNALAHALQS-SRHDCDLLREQYEEEQEGKAELQRAL 1362
Query: 357 EKRKLQ-RELRT-----ALDKIEEMEMTNSHLAKRLEKMKANRTALLAQ 399
K + + RT A+ + EE+E LA+RL+ + A+ A+
Sbjct: 1363 SKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAK 1411
Score = 48.9 bits (115), Expect = 8e-06
Identities = 73/407 (17%), Positives = 156/407 (38%), Gaps = 60/407 (14%)
Query: 5 ASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAAR--AEARDIRMRELERQQKELDE 62
A+ K + + S DE ++ + RE +A A + A +A + ++ L + + +L++
Sbjct: 971 ATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQ 1030
Query: 63 KSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTS----SLIDPDTSLSELRESLS- 117
+ + S L N R+ GD S++D + +L E L
Sbjct: 1031 QVED------LESSLEQEKKLRVDLERNK-RKLEGDLKLAQESILDLENDKQQLDERLKK 1083
Query: 118 ------EVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQ-------EEQMAEFYRE 164
+++ K + Q + L +++ L++ IE + E+Q +++ RE
Sbjct: 1084 KDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARE 1143
Query: 165 NEEKSKELERQKHMCSV-LQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVA 223
EE S+ LE + S ++ + E L+ R +L E + HE +
Sbjct: 1144 LEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEE-------------ATLQHEAMV 1190
Query: 224 GAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGT 283
A+ ++ E E + ++++K +LE+E+ +
Sbjct: 1191 AALRKKHADSV-------------------AELGEQIDNLQRVKQKLEKEKSEFKLEIDD 1231
Query: 284 VGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTA 343
+ + S ++ R Q+SE + K + ++ ++ L SRL+ +
Sbjct: 1232 LSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQ 1291
Query: 344 AENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMK 390
E E + +L K+ ++ ++EE + LA L+ +
Sbjct: 1292 LEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSR 1338
Score = 48.9 bits (115), Expect = 8e-06
Identities = 70/380 (18%), Positives = 156/380 (41%), Gaps = 45/380 (11%)
Query: 13 VKDRFSAEDEALSNIAR---EAEARLAAKRAARAEARDIRMRELERQQKELDEKSDKQYA 69
+++++ E E + + R +A + +A R R ELE +K+L ++ Q +
Sbjct: 1344 LREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRL--QDS 1401
Query: 70 ENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSEVEEKYKKAMV- 128
E + AS + +R G+ L+ + L +L + + + K +
Sbjct: 1402 EEQVEAVNAKCASLE-----KTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAE 1456
Query: 129 -------SNAQLD---NEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHM 178
S A+L+ E +L ++ LK+ EE +Q+ REN+ +E+
Sbjct: 1457 WKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQ 1516
Query: 179 CSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLE 238
+ + EL++ +Q + +EK I + +EA LE
Sbjct: 1517 IAENGKTIHELEKSRKQIE--LEK---------------------ADIQLALEEAEAALE 1553
Query: 239 SAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQF 298
L ++L +L K E+ +I + ++E+ ++ R T+ + S +
Sbjct: 1554 HEEAKILRIQL-ELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEA 1612
Query: 299 IEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEK 358
I +++ ++E + +LS A + + + ++GQ+ + ++A + +++LK +
Sbjct: 1613 IRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQL 1672
Query: 359 RKLQRELRTALDKIEEMEMT 378
++R ++EE+ T
Sbjct: 1673 AIVERRANLLQAEVEELRAT 1692
Score = 33.9 bits (76), Expect = 0.27
Identities = 31/145 (21%), Positives = 61/145 (42%), Gaps = 14/145 (9%)
Query: 255 EKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKF 314
+ EE Q+ K K QLE + ++ V + A + + + +R + SE K
Sbjct: 901 DAEERCDQLIKAKFQLEAKIKE-------VTERAEDEEEINAELTAKKRKLEDECSELKK 953
Query: 315 KLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTAL----- 369
+ E + +E+ E +V ++ +L EK+ LQ + AL
Sbjct: 954 DIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQA 1013
Query: 370 --DKIEEMEMTNSHLAKRLEKMKAN 392
DK+ + T S L +++E ++++
Sbjct: 1014 EEDKVNSLNKTKSKLEQQVEDLESS 1038
Score = 32.7 bits (73), Expect = 0.60
Identities = 77/376 (20%), Positives = 151/376 (40%), Gaps = 45/376 (11%)
Query: 43 AEARDIRMRELERQQKELDEKSDKQYAENYTRPSSRNSASATTPLSG--NSSRRGSGDTS 100
A A D + R ++ E K ++ AE S + S S +T L N+
Sbjct: 1440 AAALDKKQRNFDKVLAEWKTKCEESQAE--LEASLKESRSLSTELFKLKNAYEEALDQLE 1497
Query: 101 SLIDPDTSL----SELRESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEE 156
++ + +L ++L E ++E + + S Q++ EK ++ ++ + +E +E
Sbjct: 1498 TVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEA 1557
Query: 157 QM-----------AEFYRENEEKSKELERQKHMCSVLQHKMEE-LKEGLRQRDELIEKHG 204
++ +E R+ EK +E+E+ K M+ L +R R+E I
Sbjct: 1558 KILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKK 1617
Query: 205 LVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIR 264
+ +SH A T+ + Q + LD LR KE+L R
Sbjct: 1618 KMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVER 1677
Query: 265 K---LKLQLEEERQKCSRNDGT--VGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKA 319
+ L+ ++EE R + + + + L + +Q + Q N + K KL
Sbjct: 1678 RANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQ---NTSLIHTKKKL--- 1731
Query: 320 EQDITTLEQSISRLEGQVLRYKTAAENAEK------VEDELKAEKRKLQRELRTALDKIE 373
E + +L+ +V A NAE+ + + AE+ K +++ L++++
Sbjct: 1732 -------ETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMK 1784
Query: 374 E-MEMTNSHLAKRLEK 388
+ +E T L RL++
Sbjct: 1785 KNLEQTVKDLQHRLDE 1800
Score = 29.6 bits (65), Expect = 5.0
Identities = 38/190 (20%), Positives = 74/190 (38%), Gaps = 31/190 (16%)
Query: 16 RFSAEDEALSNIAREAEARL------AAKRAARAEARDIRMRELERQQKELDEK-SDKQY 68
+ +E E S AR AE + AA A + LER +K L++ D Q+
Sbjct: 1737 QLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQH 1796
Query: 69 AENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSEVEEKYKKAMV 128
R + L G + + +T + EL L ++K +++
Sbjct: 1797 ---------RLDEAEQLALKGGKKQ--------IQKLETRIRELEFELEGEQKKNTESVK 1839
Query: 129 SNAQLDNEKNNLIYQVDT-------LKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSV 181
+ + L YQ + L+D++++ + ++ + R+ EE ++
Sbjct: 1840 GLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRK 1899
Query: 182 LQHKMEELKE 191
QH++EE +E
Sbjct: 1900 AQHELEEAEE 1909
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 60.5 bits (145), Expect = 3e-09
Identities = 81/395 (20%), Positives = 165/395 (41%), Gaps = 49/395 (12%)
Query: 21 DEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKELDEKS-----DKQYAENYTRP 75
+EA + ++AEA L+ + +A A D + R Q+ELD+ + +Q A N +
Sbjct: 1391 EEAKKKLLKDAEA-LSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKK 1449
Query: 76 SSR--NSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSEVEEKYKKAMVSNAQL 133
+ + +S + + + +T L +L E E ++ N QL
Sbjct: 1450 QKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQL 1509
Query: 134 DNEKNNL----------IYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQ 183
+ +L +++++ K +E+Q E+M E E++ + E K V
Sbjct: 1510 RADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNM 1569
Query: 184 HKME-ELKEGLRQRDELIE-KHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAG 241
M+ + + L+ RDE E K L+I ++ E A+ V S++ ++
Sbjct: 1570 QAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEI----D 1625
Query: 242 EGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEM 301
L+ ++ ++E++ Q+RKL+ Q+++ ++ +L+
Sbjct: 1626 LKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQR-------------------ELEEARA 1666
Query: 302 QRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKL 361
RD E + ++E+ + +LE I +L+ ++ + A +AE+ DEL E
Sbjct: 1667 SRD------EIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNS 1720
Query: 362 QRELRTALDKIEEMEMTNSHLAKRLEKMKANRTAL 396
LD+ +E + L + LE+ ++N L
Sbjct: 1721 ASGKSALLDEKRRLEARIAQLEEELEEEQSNMELL 1755
Score = 57.8 bits (138), Expect = 2e-08
Identities = 76/398 (19%), Positives = 160/398 (40%), Gaps = 53/398 (13%)
Query: 13 VKDRFSAEDEALSNIAREAEARLAAKRAARAEAR-DIRMRELERQQKELDEKSDKQYAEN 71
+K++ ED ++ AE AK A+ + ++ + +LE + K+ E+ +Q E
Sbjct: 998 IKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKK--EEKTRQELEK 1055
Query: 72 YTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDP----DTSLSELRESLSEVEEKYKKAM 127
+ R+ G+T+ L D + EL+ L++ EE+ + A+
Sbjct: 1056 -------------------AKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGAL 1096
Query: 128 VSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKME 187
KNN + V L+ I E +E +F E ++K ++++ + L+
Sbjct: 1097 ARGDDETLHKNNALKVVRELQAQIAELQE---DFESEKASRNKAEKQKRDLSEELEALKT 1153
Query: 188 ELKEGL-----RQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGE 242
EL++ L +Q + + + +HE I + Q A LE
Sbjct: 1154 ELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHE---AQIQDMRQRHATALE---- 1206
Query: 243 GPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQ 302
E E L Q ++ K LE+ +Q ++ + + + +
Sbjct: 1207 ------------ELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKR 1254
Query: 303 RDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQ 362
+ + Q+ E K+S+ ++ L + S+L+ ++ T E AEK + + L+
Sbjct: 1255 KKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLE 1314
Query: 363 RELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ 400
+L+ + ++E +L+ R+ +++ + +L QQ
Sbjct: 1315 SQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQ 1352
Score = 55.5 bits (132), Expect = 9e-08
Identities = 60/293 (20%), Positives = 128/293 (43%), Gaps = 39/293 (13%)
Query: 106 DTSLSELRESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYREN 165
D L +++E ++VE + ++ + QL EKN L Q+ ++ E EE A +
Sbjct: 858 DEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKK 917
Query: 166 EEKSKEL-------ERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVS 218
+E + L E ++ +LQ++ ++++ ++ +E +++ +G
Sbjct: 918 QELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEE------EGARQKLQL 971
Query: 219 HEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCS 278
+ A A +E +LE K EK+ + +I + QL EE +K
Sbjct: 972 EKVTAEAKIKKMEEEILLLEDQNS--------KFIKEKKLMEDRIAECSSQLAEEEEKAK 1023
Query: 279 RNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVL 338
+LA ++N ++ IS+ + +L K E+ LE++ +L+G+
Sbjct: 1024 -------NLAKIRNKQEVM-----------ISDLEERLKKEEKTRQELEKAKRKLDGETT 1065
Query: 339 RYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKA 391
+ + DELK + K + EL+ AL + ++ + ++ K + +++A
Sbjct: 1066 DLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQA 1118
Score = 52.4 bits (124), Expect = 7e-07
Identities = 67/293 (22%), Positives = 115/293 (39%), Gaps = 26/293 (8%)
Query: 104 DPDTSLSELRESLSEV----EEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMA 159
D L E R S E+ +E KK A++ + L + +E++E
Sbjct: 1656 DYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELAD 1715
Query: 160 EFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSH 219
E KS L+ ++ + + + EEL+E + L ++ + T N +++
Sbjct: 1716 EITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAA 1775
Query: 220 EPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGE-KEELLSQIRKLKL---QLEEERQ 275
E A S A Q LE + L +L++L G K + + I L+ QLEE+ +
Sbjct: 1776 ERSAAQ---KSDNARQQLERQNK-ELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLE 1831
Query: 276 KCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEG 335
+ ++ L + D R +YK ++ KA + L++ +
Sbjct: 1832 QEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQL----- 1886
Query: 336 QVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEK 388
E AE+ A +RKLQREL A + E + S L RL +
Sbjct: 1887 ---------EEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRR 1930
Score = 50.4 bits (119), Expect = 3e-06
Identities = 91/414 (21%), Positives = 168/414 (40%), Gaps = 50/414 (12%)
Query: 18 SAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKELDEKSDK----------- 66
+ E + L + E+E + K A+ + ++ E +R + EL EK+ K
Sbjct: 1237 ACEVKVLQQVKAESEHK-RKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTL 1295
Query: 67 -QYAENYTRPSSRNSASA------TTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSEV 119
+ AE ++++AS T L +R+ +S + + + L+E E
Sbjct: 1296 LEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEE 1355
Query: 120 EEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMC 179
EE K L ++ + +VD IE EE + ++ E S+ LE +
Sbjct: 1356 EEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEK---- 1411
Query: 180 SVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHE-PVAGAITVVSQEAAQVLE 238
++ K+E+ K L+Q E L + D+ H+ VA + ++ Q+L
Sbjct: 1412 ALAYDKLEKTKNRLQQ-----ELDDLTV--------DLDHQRQVASNLEKKQKKFDQLLA 1458
Query: 239 -----SAGEGPLDVRLRKLAGEKE-ELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQN 292
SA R A EKE + LS R L+ LE + + +N D+ L +
Sbjct: 1459 EEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMS 1518
Query: 293 GSD------LQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAEN 346
D + + +R +Q+ E + +L + E ++ E + RLE + K E
Sbjct: 1519 SKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFER 1578
Query: 347 AEKVEDELKAEKRKLQ-RELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQ 399
+ DE EK++L +++R ++E+ + +KM+ + L AQ
Sbjct: 1579 DLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQ 1632
Score = 48.9 bits (115), Expect = 8e-06
Identities = 62/271 (22%), Positives = 119/271 (43%), Gaps = 26/271 (9%)
Query: 143 QVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEK 202
+V L V ++EE A K +EL + K + ++ ++EE++ R+ +L+E+
Sbjct: 840 KVKPLLQVTRQEEELQA--------KDEELLKVKEKQTKVEGELEEME---RKHQQLLEE 888
Query: 203 HGLVIIP-DGTPNGDVSHEPVAGAITVVSQEAAQVL---ESAGEGPLDVRLRKLAGEKEE 258
++ E + + QE ++L ES E + R + L EK++
Sbjct: 889 KNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEE-EERNQILQNEKKK 947
Query: 259 LLSQIRKLKLQLEEE---RQKCSRNDGT-------VGDLAGLQNGSDLQFIEMQRDANRQ 308
+ + I+ L+ QL+EE RQK T + + L + +FI+ ++ +
Sbjct: 948 MQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDR 1007
Query: 309 ISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTA 368
I+E +L++ E+ L + ++ E + + + EK EL+ KRKL E
Sbjct: 1008 IAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDL 1067
Query: 369 LDKIEEMEMTNSHLAKRLEKMKANRTALLAQ 399
D+I E++ L +L K + LA+
Sbjct: 1068 QDQIAELQAQIDELKLQLAKKEEELQGALAR 1098
Score = 47.0 bits (110), Expect = 3e-05
Identities = 57/358 (15%), Positives = 151/358 (42%), Gaps = 13/358 (3%)
Query: 49 RMRELERQQKELDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTS 108
R+R+LE ++ L E+ ++ E R + A ++ ++ D ++ + +
Sbjct: 1337 RIRQLEEEKNSLQEQQEE---EEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEA 1393
Query: 109 LSELRESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEK 168
+L + + ++ ++ ++ +L+ KN L ++D L ++ Q + + ++ ++
Sbjct: 1394 KKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKF 1453
Query: 169 SKELERQKHMCSVLQHKMEELKEGLRQRDE--LIEKHGLVIIPDGTPNGDVSHEPVAGAI 226
+ L +K + + + + + R+++ L L + + ++ + +
Sbjct: 1454 DQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADM 1513
Query: 227 TVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGD 286
+ V ++ E L+ R L + EE+ +Q+ +L+ +L+ R + +
Sbjct: 1514 EDLMSSKDDVGKNVHE--LEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQA 1571
Query: 287 LAGLQNGSDLQFIEMQRDANR-----QISEYKFKLSKAEQDITTLEQSISRLEGQVLRYK 341
+ Q DLQ + Q + + Q+ E + +L + S ++E + +
Sbjct: 1572 MKA-QFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLE 1630
Query: 342 TAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQ 399
E A K DE+ + RKLQ +++ ++EE + + + ++ + +L A+
Sbjct: 1631 AQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAE 1688
Score = 38.1 bits (87), Expect = 0.014
Identities = 43/167 (25%), Positives = 73/167 (43%), Gaps = 11/167 (6%)
Query: 33 ARLAAKRAARAEARDIRMRELERQQKELDEKSDKQYAENYTRPSSRNSASATTPLSGNSS 92
A LAA+R+A A+ D ++LERQ KEL K+ Q E + + + SA G
Sbjct: 1771 AELAAERSA-AQKSDNARQQLERQNKEL--KAKLQELEGAVKSKFKATISALEAKIGQLE 1827
Query: 93 RRGSGDTSSLIDPDTSL----SELRESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLK 148
+ + + + +L+E +VE++ + A Q+ EK N ++ LK
Sbjct: 1828 EQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQM--EKANA--RMKQLK 1883
Query: 149 DVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQ 195
+EE EE+ + +EL+ L ++ LK LR+
Sbjct: 1884 RQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRR 1930
>gi|239745085 PREDICTED: similar to Golgin subfamily A member 8-like
protein 1 isoform 3 [Homo sapiens]
Length = 601
Score = 59.3 bits (142), Expect = 6e-09
Identities = 78/364 (21%), Positives = 149/364 (40%), Gaps = 21/364 (5%)
Query: 32 EARLAAKRAARAEARDIRMRELERQQKELDEKSDKQYAENYTRPSSRNSASATTPLSGNS 91
+ARL A E R ++ +R+ KE +++ R N + T SG
Sbjct: 4 QARLPPHPAMAEETRQSKLAAAKRKLKEYWQRNSPGVPAGAKRNRKTNGSIHETATSGGC 63
Query: 92 SRRG--SGDTSSLIDPDTSLSELRESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKD 149
G S +SSL P + EL K + + L +K +++Q++ K
Sbjct: 64 HSPGDSSSTSSSLHAPQSPCQELAVVPDSRSVKVSQLKNTIKSLKQQKKQVVHQLEEEKK 123
Query: 150 VIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIP 209
E+Q AE RE E + + L QK L + K LR +E E L +
Sbjct: 124 A--NNEKQKAE--RELEVQIQRLNIQK---GKLNTDLYHTKRSLRYFEE--ESKDLAVRL 174
Query: 210 DGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQ 269
+ E A+T ++ A+ S + + +L + E+ L +Q+ +LK
Sbjct: 175 QHSLQRKGELERALSAVTATQKKKAERFSSRSKARTEWKLEQSMREQALLKAQLTQLKES 234
Query: 270 LEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQS 329
L+E + + + A G ++ + R ++++ K + + + TLE+S
Sbjct: 235 LKEVQLERD-------EYAEHLKGERARWQQRMRKMSQEVCSLKKEKKHDKYRVETLERS 287
Query: 330 ISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQR---ELRTALDKIEEMEMTNSHLAKRL 386
+S+L+ Q+ A E EL+ +++L+R L+ ++ + + + N +RL
Sbjct: 288 LSKLKNQMAEPLPPEPPAVPSEAELQHLRKELERVAGALQAQVEYNQRISLLNEGQKERL 347
Query: 387 EKMK 390
+ +
Sbjct: 348 REQQ 351
>gi|239745081 PREDICTED: similar to Golgin subfamily A member 8-like
protein 1 isoform 2 [Homo sapiens]
Length = 629
Score = 59.3 bits (142), Expect = 6e-09
Identities = 78/364 (21%), Positives = 149/364 (40%), Gaps = 21/364 (5%)
Query: 32 EARLAAKRAARAEARDIRMRELERQQKELDEKSDKQYAENYTRPSSRNSASATTPLSGNS 91
+ARL A E R ++ +R+ KE +++ R N + T SG
Sbjct: 4 QARLPPHPAMAEETRQSKLAAAKRKLKEYWQRNSPGVPAGAKRNRKTNGSIHETATSGGC 63
Query: 92 SRRG--SGDTSSLIDPDTSLSELRESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKD 149
G S +SSL P + EL K + + L +K +++Q++ K
Sbjct: 64 HSPGDSSSTSSSLHAPQSPCQELAVVPDSRSVKVSQLKNTIKSLKQQKKQVVHQLEEEKK 123
Query: 150 VIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIP 209
E+Q AE RE E + + L QK L + K LR +E E L +
Sbjct: 124 A--NNEKQKAE--RELEVQIQRLNIQK---GKLNTDLYHTKRSLRYFEE--ESKDLAVRL 174
Query: 210 DGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQ 269
+ E A+T ++ A+ S + + +L + E+ L +Q+ +LK
Sbjct: 175 QHSLQRKGELERALSAVTATQKKKAERFSSRSKARTEWKLEQSMREQALLKAQLTQLKES 234
Query: 270 LEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQS 329
L+E + + + A G ++ + R ++++ K + + + TLE+S
Sbjct: 235 LKEVQLERD-------EYAEHLKGERARWQQRMRKMSQEVCSLKKEKKHDKYRVETLERS 287
Query: 330 ISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQR---ELRTALDKIEEMEMTNSHLAKRL 386
+S+L+ Q+ A E EL+ +++L+R L+ ++ + + + N +RL
Sbjct: 288 LSKLKNQMAEPLPPEPPAVPSEAELQHLRKELERVAGALQAQVEYNQRISLLNEGQKERL 347
Query: 387 EKMK 390
+ +
Sbjct: 348 REQQ 351
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 59.3 bits (142), Expect = 6e-09
Identities = 93/414 (22%), Positives = 172/414 (41%), Gaps = 50/414 (12%)
Query: 8 RKRTPVKDRFSAEDEALSNIAREAEARLAA-----------KRAARAEARDIRMRELERQ 56
+++T + DR E SN +E EA K A +AEA + + L+
Sbjct: 1939 QEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQET 1998
Query: 57 QKELDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRESL 116
+K + EK + Q R + A L + + S + +T L +LR+
Sbjct: 1999 EKLMKEKLEVQCQAEKVRDDLQKQVKA---LEIDVEEQVSRFIELEQEKNTELMDLRQQN 2055
Query: 117 SEVEEKYKKA--MVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFY-------RENEE 167
+E++ +K + +D E ++Q + K +E+Q + + F RE E+
Sbjct: 2056 QALEKQLEKMRKFLDEQAIDREHERDVFQQEIQK--LEQQLKVVPRFQPISEHQTREVEQ 2113
Query: 168 KSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAIT 227
+ L+ + CS L E+L+ +++R+E IEK + + A+
Sbjct: 2114 LANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRV------------RELEQALL 2161
Query: 228 VVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDL 287
V ++ +E+ E L+V+L+ + +I L+ QLE+ R++ + V L
Sbjct: 2162 VEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQL 2221
Query: 288 AGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTL----EQSISRLEGQVLRYKTA 343
L+ + + Q E + KL K + + L ++S + VL K A
Sbjct: 2222 -----HMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFA 2276
Query: 344 AENAEK-VE-DELKAEKRKLQRELRTALDK--IEEMEMTNSHLAKRLEKMKANR 393
EK VE D+L + KLQ++L+ D IEE L ++E + +++
Sbjct: 2277 QIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQ 2330
Score = 43.5 bits (101), Expect = 3e-04
Identities = 80/373 (21%), Positives = 152/373 (40%), Gaps = 59/373 (15%)
Query: 9 KRTPVKDRFSAEDEALSNIARE-AEARLAAKRAARAEARDIRMRELERQQKELDEKSDKQ 67
+ T ++++ S+E ++ + E A+ +L + +A+ + ++ELE + E+ +K+D+
Sbjct: 3138 RATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHK--HLKELEAFRLEVKDKTDEV 3195
Query: 68 YAENYTRPSS-RNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSEVEEKYKKA 126
+ N T S + S L ++ G + E E E K +
Sbjct: 3196 HLLNDTLASEQKKSRELQWALEKEKAKLGRSE---------------ERDKEELEDLKFS 3240
Query: 127 MVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFY--RENEEKSKELERQKHMCSVLQH 184
+ S Q + + N L+ Q L + +++ E Y + +EE+ + LE Q +L+
Sbjct: 3241 LESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQV----LLES 3296
Query: 185 KMEELKEGLRQRDELIEKHGLVIIPDGT-------PNGDV----------SHEPVAGAIT 227
+ ++E D E H + DGT P+ D+ H + +
Sbjct: 3297 EKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLN 3356
Query: 228 VVSQEAAQVLESAGEGPLD--VRLRKLAGEKE----------ELLSQIRKLKLQLEEERQ 275
+ L++ + D V + L E+E EL S++ L+ QLEE+RQ
Sbjct: 3357 ETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQ 3416
Query: 276 KCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEG 335
+ + D L G+ + Q E++R+ R E + L + + TT + R
Sbjct: 3417 QVYKLDLEGQRLQGIM--QEFQKQELEREEKR---ESRRILYQNLNEPTTWSLTSDRTRN 3471
Query: 336 QVLRYKTAAENAE 348
VL+ K E E
Sbjct: 3472 WVLQQKIEGETKE 3484
Score = 38.1 bits (87), Expect = 0.014
Identities = 62/313 (19%), Positives = 126/313 (40%), Gaps = 34/313 (10%)
Query: 110 SELRESLSEVEEKYKKAMVSNAQLDNEKNNLIYQ--------VDTLKDVIEEQEEQMAEF 161
S++ E +E+ ++ ++ + ++D E L+ V+ L + I E Q+
Sbjct: 1812 SKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHA 1871
Query: 162 YRENEEKSKELERQKHMCSVLQHKMEELKEGL----RQRDEL-IEKHGLVIIPDGTPNGD 216
E +E RQK + EEL+E L R R++L +E + DG +
Sbjct: 1872 KVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEK 1931
Query: 217 VSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRK---------LAGEKEELLSQIRKLK 267
E T + Q L A ++ + L+ +KE + ++ ++
Sbjct: 1932 TLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVE 1991
Query: 268 LQLEEERQKCSRNDGTVGDLA-GLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTL 326
QL +E +K + V A +++ Q ++ D Q+S + + ++ L
Sbjct: 1992 QQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDL 2051
Query: 327 EQSISRLEGQVLRYK----TAAENAEKVEDELKAEKRKLQRELRT-------ALDKIEEM 375
Q LE Q+ + + A + E D + E +KL+++L+ + + E+
Sbjct: 2052 RQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREV 2111
Query: 376 EMTNSHLAKRLEK 388
E +HL ++ +K
Sbjct: 2112 EQLANHLKEKTDK 2124
Score = 37.7 bits (86), Expect = 0.019
Identities = 66/323 (20%), Positives = 132/323 (40%), Gaps = 60/323 (18%)
Query: 98 DTSSLIDPDTSL--SELRESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQE 155
+ S L D SL S+ E ++ E K+ + Q + EK L +V L+ E E
Sbjct: 698 EISKLKDLQQSLVNSKSEEMTLQINELQKEIEILR-QEEKEKGTLEQEVQELQLKTELLE 756
Query: 156 EQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNG 215
+QM E + +EK +LE + S+L+ + + L++ L+ + ++ L+ +
Sbjct: 757 KQMKEKENDLQEKFAQLEAEN---SILKDEKKTLEDMLKIHTPVSQEERLIFLD------ 807
Query: 216 DVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQ 275
++ S+ V E + L E E+L Q +L ++E++R
Sbjct: 808 -----------SIKSKSKDSVWEK--------EIEILIEENEDLKQQCIQLNEEIEKQRN 848
Query: 276 KCSRNDGTV------------------GDLAGLQNGSDLQFIEMQRDANRQI-------S 310
S + DL +N +L++ + N ++ +
Sbjct: 849 TFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPT 908
Query: 311 EYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALD 370
K K S ++D T + +++ G+V+ K E EK+E K EK +L + L +
Sbjct: 909 TVKMKSSVFDEDKTFVAETLEM--GEVVE-KDTTELMEKLE-VTKREKLELSQRLSDLSE 964
Query: 371 KIEEMEMTNSHLAKRLEKMKANR 393
++++ S L + ++ +K +
Sbjct: 965 QLKQKHGEISFLNEEVKSLKQEK 987
Score = 34.7 bits (78), Expect = 0.16
Identities = 67/408 (16%), Positives = 161/408 (39%), Gaps = 56/408 (13%)
Query: 14 KDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKELDEKSDKQYAENYT 73
+D +++ ++N+ + E E + + M +LE Q+KE + + EN
Sbjct: 2187 RDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHM-QLEIQKKESTTRLQELEQENKL 2245
Query: 74 RPSSRNSASATTPLSGNSSRRGS----GDTSSLI-DPDTSLSELRESLSEVEEKYKKAMV 128
S S + G + +I + + + +L E +++++++ K +
Sbjct: 2246 FKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLK--IT 2303
Query: 129 SNAQLDNEKNNLIYQVDT----------------------LKDVIEEQEEQMAEFYREN- 165
++ ++ EKN LI ++T L +VIE+ ++++A ++
Sbjct: 2304 TDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTS 2363
Query: 166 ---EEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPV 222
S+E + KH V+ + L++ + +E + V+ ++ E
Sbjct: 2364 MNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELF 2423
Query: 223 AGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQ-LEEERQKCSRND 281
+ +E+ + ++S E ++V + L+ +K EL + + L+ LE + S +
Sbjct: 2424 S---LKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEE 2480
Query: 282 GTVGDLAGLQ----------NGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSIS 331
G + L+ + DL+ + + + +F+ ++ I L+
Sbjct: 2481 NGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQ---- 2536
Query: 332 RLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTN 379
+++ K AA +++ E E K ++ +T + E + N
Sbjct: 2537 ----KIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQN 2580
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 58.9 bits (141), Expect = 8e-09
Identities = 90/427 (21%), Positives = 176/427 (41%), Gaps = 63/427 (14%)
Query: 30 EAEARLAAKRAARAEARDIRM---RELERQQKELDEK----------SDKQYAENYTRPS 76
E E L A+R ARA+ +R RELE + L+E + K+ AE
Sbjct: 1117 ELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRR 1176
Query: 77 SRNSASATTPLSGNSSRRGSGDT-SSLIDPDTSLSELRESLSEVEEKYKKAM---VSNA- 131
A+ + + R+ D+ + L + +L +++ L + + ++K + SN
Sbjct: 1177 DLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNME 1236
Query: 132 QLDNEKNNLIYQVDTLKDVIEEQEE--------------QMAEFYRENEEKSKELERQKH 177
Q+ K NL TL+D + E Q A+ EN E S++L+ ++
Sbjct: 1237 QIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEA 1296
Query: 178 MCSVLQH-------KMEELKEGLRQRDELIEKHGLV-IIPDGTPNGDVSHEPVAGAITVV 229
+ S L ++E+LK L + E+ K+ L + + D+ E T
Sbjct: 1297 LISQLTRGKLTYTQQLEDLKRQLEE--EVKAKNALAHALQSARHDCDLLREQYEEE-TEA 1353
Query: 230 SQEAAQVLESAG----------EGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSR 279
E +VL A E R +L K++L ++++ + +E KCS
Sbjct: 1354 KAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSS 1413
Query: 280 NDGT-------VGDL---AGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQS 329
+ T + DL N + + QR+ ++ ++E+K K +++ ++ + ++
Sbjct: 1414 LEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKE 1473
Query: 330 ISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKM 389
L ++ + K A E + + + K E + LQ E+ +++ T L K +++
Sbjct: 1474 ARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQL 1533
Query: 390 KANRTAL 396
+A + L
Sbjct: 1534 EAEKMEL 1540
Score = 57.4 bits (137), Expect = 2e-08
Identities = 60/297 (20%), Positives = 128/297 (43%), Gaps = 52/297 (17%)
Query: 106 DTSLSELRESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYREN 165
+ ++ ++E + ++E +K+ +L+ + +L+ + + L+ ++ +++ +A+
Sbjct: 846 EKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADA---- 901
Query: 166 EEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGA 225
EE+ +L + K L+ K++E+ E L +E+
Sbjct: 902 EERCDQLIKNKIQ---LEAKVKEMNERLEDEEEM-------------------------- 932
Query: 226 ITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVG 285
L + RKL E EL I L+L L + ++ + V
Sbjct: 933 ----------------NAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVK 976
Query: 286 DLAGLQNGSD--LQFIEMQRDANRQISEYKFKLSKAEQD-ITTLEQSISRLEGQVLRYKT 342
+L G D + + ++ A ++ + +AE+D + TL ++ +LE QV +
Sbjct: 977 NLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEG 1036
Query: 343 AAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQ 399
+ E +KV +L+ KRKL+ +L+ + I ++E L +RL+K AL A+
Sbjct: 1037 SLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNAR 1093
Score = 55.5 bits (132), Expect = 9e-08
Identities = 84/406 (20%), Positives = 169/406 (41%), Gaps = 62/406 (15%)
Query: 13 VKDRFSAEDEALSNIAREAEARLAAKRA----ARAEARDIRMRELERQQKELDEKSDKQY 68
V+ + AE L + EAEA L + A+ E I+ E+ER+ E DE+ + Q
Sbjct: 1529 VRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKA-EIERKLAEKDEEME-QA 1586
Query: 69 AENYTR--PSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSEVEEKYKKA 126
N+ R S + S A T + R L + + LS +E +++ K
Sbjct: 1587 KRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSL 1646
Query: 127 MV----SNAQLDN----------------EKNNLIY-QVDTLKDVIEEQEEQMAEFYREN 165
+ QLD+ +NNL+ +++ L+ V+E+ E +E
Sbjct: 1647 QSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQEL 1706
Query: 166 EEKSKELE-----------RQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPN 214
E S+ ++ ++K M + L E++E +++ EK I
Sbjct: 1707 IETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMA 1766
Query: 215 GDVSHEPVAGA-ITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELL---SQIRKLKLQL 270
++ E A + + + Q ++ + L G K++L +++R+L+ +L
Sbjct: 1767 EELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENEL 1826
Query: 271 EEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSI 330
E E+++ + + ++ R + R+I E ++ + +++ L+ +
Sbjct: 1827 EAEQKR------------------NAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLV 1868
Query: 331 SRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEME 376
+L+ +V YK AE AE+ + ++ RK+Q EL A ++ + E
Sbjct: 1869 DKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAE 1914
Score = 52.0 bits (123), Expect = 9e-07
Identities = 74/321 (23%), Positives = 128/321 (39%), Gaps = 37/321 (11%)
Query: 111 ELRESLSEVEEKYKKAMVSNAQLD---NEKNNLIYQVD----TLKDVIEEQEEQMAEFYR 163
E + S++++ + K N +L +EK LI Q+ T +E+ + Q+ E +
Sbjct: 1265 ETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVK 1324
Query: 164 ENEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVA 223
+ L+ +H C +L+ + EE E + ++ K + T +E A
Sbjct: 1325 AKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRT-----KYETDA 1379
Query: 224 GAITVVSQEA----AQVLESAGEG--PLDVRLRKLAGEKEELLSQIRKLKLQLEEER--- 274
T +EA AQ L+ A E ++ + L K L ++I L + +E
Sbjct: 1380 IQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAA 1439
Query: 275 ---QKCSRN-DGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKA----------- 319
K RN D + + S + Q++A R +S FKL A
Sbjct: 1440 AALDKKQRNFDKILAEWKQKYEESQSELESSQKEA-RSLSTELFKLKNAYEESLEHLETF 1498
Query: 320 EQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTN 379
+++ L++ IS L Q+ EKV +L+AEK +LQ L A +E E
Sbjct: 1499 KRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKI 1558
Query: 380 SHLAKRLEKMKANRTALLAQQ 400
++KA LA++
Sbjct: 1559 LRAQLEFNQIKAEIERKLAEK 1579
Score = 49.3 bits (116), Expect = 6e-06
Identities = 73/311 (23%), Positives = 144/311 (46%), Gaps = 57/311 (18%)
Query: 110 SELRESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEE------------- 156
+ L+E+L + E + K+ L EKN+L QV +D + + EE
Sbjct: 857 TRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLE 916
Query: 157 ----QMAEFYRENEEKSKELERQKHM----CSVLQHKMEELKEGLRQRDELIEKHGLVII 208
+M E + EE + EL +K CS L+ +++L+ L + ++ EKH
Sbjct: 917 AKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEK--EKHA---- 970
Query: 209 PDGTPNGDVS-HEPVAGAITVVSQ--EAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRK 265
T N + E +AG ++++ + + L+ A + LD L E E+ ++ + K
Sbjct: 971 ---TENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALD----DLQAE-EDKVNTLTK 1022
Query: 266 LKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITT 325
K++LE++ V DL GS Q +++ D R + + L ++ I
Sbjct: 1023 AKVKLEQQ----------VDDL----EGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMD 1068
Query: 326 LEQSISRLEGQVLR--YKTAAENAEKVEDE--LKAEKRKLQRELRTALDKIEEMEMTNSH 381
LE +L+ ++ + ++ A NA ++EDE L ++ +K +EL+ ++++EE
Sbjct: 1069 LENDKQQLDERLKKKDFELNALNA-RIEDEQALGSQLQKKLKELQARIEELEEELEAERT 1127
Query: 382 LAKRLEKMKAN 392
++EK++++
Sbjct: 1128 ARAKVEKLRSD 1138
Score = 48.1 bits (113), Expect = 1e-05
Identities = 83/410 (20%), Positives = 166/410 (40%), Gaps = 84/410 (20%)
Query: 21 DEALSNIAREAEARLAAKRAARAEARDIRMRE-----LERQQKELDEKSDKQYAENYTRP 75
D+ ++ +E + R+ +RA R D+++ + LE +++LDE+ K+ E
Sbjct: 1032 DDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFEL---- 1087
Query: 76 SSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSEVEEKYKKAMVSNAQLDN 135
++ N+ G+ ++ L EL+ + E+EE+ + + A+++
Sbjct: 1088 NALNARIEDEQALGSQLQK-------------KLKELQARIEELEEELEAERTARAKVEK 1134
Query: 136 EKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEELKEGLRQ 195
+++L +++ + + +EE + N+++ E ++ + + E LR
Sbjct: 1135 LRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALR- 1193
Query: 196 RDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLE-SAGEGPLDV-----RL 249
+KH + G ++ Q Q LE E L++ +
Sbjct: 1194 -----KKHADSVAELGEQIDNL-------------QRVKQKLEKEKSEFKLELDDVTSNM 1235
Query: 250 RKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQI 309
++ K L R L+ Q+ E R K +V DL + + E+ +RQ+
Sbjct: 1236 EQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGEL----SRQL 1291
Query: 310 SEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENA----------------EKVEDE 353
E + +S+ + T Q + L+ Q L + A+NA E+ E+E
Sbjct: 1292 DEKEALISQLTRGKLTYTQQLEDLKRQ-LEEEVKAKNALAHALQSARHDCDLLREQYEEE 1350
Query: 354 LKAEKRKLQREL----------RT-----ALDKIEEMEMTNSHLAKRLEK 388
+A K +LQR L RT A+ + EE+E LA+RL++
Sbjct: 1351 TEA-KAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQE 1399
Score = 34.3 bits (77), Expect = 0.20
Identities = 70/386 (18%), Positives = 144/386 (37%), Gaps = 40/386 (10%)
Query: 41 ARAEARDIRMRELERQQKELDEKSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTS 100
A A A D + R ++ E +K ++ +E + S S N+
Sbjct: 1437 AAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLE 1496
Query: 101 SLIDPDTSL----SELRESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEE 156
+ + +L S+L E L + + QL+ EK L ++ + +E +E
Sbjct: 1497 TFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEG 1556
Query: 157 QM-----------AEFYRENEEKSKELERQK-HMCSVLQHKMEELKEGLRQRDELIEKHG 204
++ AE R+ EK +E+E+ K + V+ L R R+E +
Sbjct: 1557 KILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKK 1616
Query: 205 LVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEEL----- 259
+ +SH A ++ Q L + LD +R KE +
Sbjct: 1617 KMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVER 1676
Query: 260 --------LSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISE 311
L ++R + Q E R+ + + L + + I ++ + +S+
Sbjct: 1677 RNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQ 1736
Query: 312 YKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVED------ELKAEKRKLQREL 365
+ ++ +A Q+ E+ + + AE +K +D +K + ++L
Sbjct: 1737 LQTEVEEAVQECRNAEEKAKK---AITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDL 1793
Query: 366 RTALDKIEEMEMTNSHLAKRLEKMKA 391
+ LD+ E++ + K+L+K++A
Sbjct: 1794 QHRLDEAEQIALKGG--KKQLQKLEA 1817
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 58.2 bits (139), Expect = 1e-08
Identities = 92/409 (22%), Positives = 181/409 (44%), Gaps = 77/409 (18%)
Query: 22 EALSNIAREAEARLAAKRAARAEARDIRMRE-----LERQQKELDEK------SDKQYAE 70
E +S + +E E A +A E + + L+ Q +L EK S KQ E
Sbjct: 537 ENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQE 596
Query: 71 NYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSE----VEEKYKKA 126
N A L R S +TS + + ++ L+E +E +S+ ++ K +
Sbjct: 597 NLHDQVQEQKAH----LRAAQDRVLSLETS-VNELNSQLNESKEKVSQLDIQIKAKTELL 651
Query: 127 MVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKM 186
+ + A ++ +L +DT ++ ++++++++ + + ++ + +L+ ++ CS L+ +
Sbjct: 652 LSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHL 711
Query: 187 EELKE---GLRQRDELIEKHGLVIIPDGTPNGDVSH-EPVAGAITVVSQEAAQVLESAGE 242
+E KE L Q+ E +E G + E + + ++A Q L+ +
Sbjct: 712 KEYKEKYLSLEQKTEELE-------------GQIKKLEADSLEVKASKEQALQDLQQQRQ 758
Query: 243 GPLDVRLR------KLAGEKE-------------ELLSQIRKLKLQLEEERQKCSRNDGT 283
D+ LR +L EKE E L I++ + EEE+Q ++ T
Sbjct: 759 LNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFET 818
Query: 284 VGDLAGLQNG----------SDLQFIEMQRDA-NRQISEYKFKLSKAEQDITTLEQSISR 332
+ +Q+ ++LQ ++M+++A ++S K KLSK +L+ S S
Sbjct: 819 LSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSD---SLKNSKSE 875
Query: 333 LEGQVLRYKTAAENAEKVEDELKAEKR-------KLQRELRTALDKIEE 374
E + + K A + EK ELK + + K Q+EL+ +L+K +E
Sbjct: 876 FEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKE 924
Score = 57.8 bits (138), Expect = 2e-08
Identities = 59/275 (21%), Positives = 123/275 (44%), Gaps = 34/275 (12%)
Query: 107 TSLSELRESLSEVEEKYKKAMVSNAQLDNEKNN--LIYQVDTLKDVIEEQEEQMAEFYRE 164
T LS +++ LS+V + K + S + +N+K ++ T K++ + + QM +E
Sbjct: 853 TELSTVKDKLSKVSDSLKNSK-SEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKE 911
Query: 165 NEEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAG 224
+E K LE++K L+ ++ ++E L Q ++++ + + + G
Sbjct: 912 QKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQN------------EKEEQQLQG 959
Query: 225 AITVVSQEAAQVLES--AGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDG 282
I + Q + Q + A +G L + + + + +L Q+ + +L E++K S
Sbjct: 960 NINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISV--- 1016
Query: 283 TVGDLAGLQNG---SDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLR 339
LQN S F ++Q D + SE L QD+ ++E+ +S + ++
Sbjct: 1017 -------LQNNYEKSQETFKQLQSDFYGRESE----LLATRQDLKSVEEKLSLAQEDLIS 1065
Query: 340 YKTAAENAEKVEDELKAEKRKLQRELRTALDKIEE 374
+ N K+ ELK K L+++ +++E
Sbjct: 1066 NRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQE 1100
Score = 57.0 bits (136), Expect = 3e-08
Identities = 85/453 (18%), Positives = 180/453 (39%), Gaps = 85/453 (18%)
Query: 20 EDEALSNIAREAEARLAAKRAARAEARD----------IRMRELERQQKELDEKSDKQYA 69
E E L + ++ +++ A+ A ++ R + ++EL++ + ++E + K
Sbjct: 247 ESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQT 306
Query: 70 ---------ENYTRPSSRNSASATTPLSGNS-------------SRRGSGDTS------S 101
++YT+ +++ + + + + SR + +TS
Sbjct: 307 LTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVE 366
Query: 102 LIDPDTSLSELRESLSEVEEKYKKAMVSNAQLDNEKN-------NLIYQVDTLKDVIEEQ 154
L + + +L+E LSEVE KY+ QL ++ L +++ L + E
Sbjct: 367 LSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLET 426
Query: 155 EEQMAEFYRENEEK----SKELERQKHMCSVLQHKMEELKEGLRQR--DELIEKHGLVII 208
E Q+ E + +E+ S++L ++ + LQ K+ L+E L+++ + +H L
Sbjct: 427 ERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQL--- 483
Query: 209 PDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGE--GPLDVRLRKLAGEKEELLSQIRKL 266
D T + + + T +EA LE G D +++ L ++ I L
Sbjct: 484 -DKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLL 542
Query: 267 KLQLEEERQKCSRNDGTVGDLAGLQ-----------------NGSDLQFIEMQRDANRQI 309
+ + E+ K +G L LQ + Q + + Q+
Sbjct: 543 EKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQV 602
Query: 310 SEYKFKLSKAEQDITTLEQSISRLEGQV-----------LRYKTAAENAEKVEDELKAEK 358
E K L A+ + +LE S++ L Q+ ++ K E E A++
Sbjct: 603 QEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQR 662
Query: 359 RKLQRELRTALDKIEEMEMTNSHLAKRLEKMKA 391
LQ L TA + +++ + + + +L+++ A
Sbjct: 663 ADLQNHLDTAQNALQDKQQELNKITTQLDQVTA 695
Score = 45.1 bits (105), Expect = 1e-04
Identities = 85/421 (20%), Positives = 171/421 (40%), Gaps = 70/421 (16%)
Query: 13 VKDRFSAEDEALSNIAREAEARLAAKRAARAEAR----------DIRMRELERQQKELDE 62
VKD+ S ++L N E E +AA + ++M ++QKEL +
Sbjct: 858 VKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKK 917
Query: 63 KSDKQYAENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRES------- 115
+K+ ++ NS + N+ ++ + L +++EL++S
Sbjct: 918 SLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQL---QGNINELKQSSEQKKKQ 974
Query: 116 LSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELE-- 173
+ ++ + K A++ +L+N+ + Q +E+ + Y +++E K+L+
Sbjct: 975 IEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSD 1034
Query: 174 ---RQKHMCSVLQH-KMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVV 229
R+ + + Q K E K L Q D + ++ + G N + A A +
Sbjct: 1035 FYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQI-----GNQNKLIQELKTAKA--TL 1087
Query: 230 SQEAA---QVLESAGEGPLDVRLRKLAGEKEEL-----LSQIRKLKLQLEEERQKCSRND 281
Q++A Q L+ + D++ K EKE + L++I ++K + E+E K +
Sbjct: 1088 EQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNE-- 1145
Query: 282 GTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYK 341
E++ I E L A+Q L Q L+G+ K
Sbjct: 1146 ------------------ELKSHKLESIKEIT-NLKDAKQ---LLIQQKLELQGKADSLK 1183
Query: 342 TAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKR---LEKMKANRTALLA 398
A E ++ + LK + +K + EL+ + IE+ +S + ++ ++K + N L
Sbjct: 1184 AAVEQEKRNQQILKDQVKKEEEELKK--EFIEKEAKLHSEIKEKEVGMKKHEENEAKLTM 1241
Query: 399 Q 399
Q
Sbjct: 1242 Q 1242
Score = 43.1 bits (100), Expect = 4e-04
Identities = 59/314 (18%), Positives = 130/314 (41%), Gaps = 47/314 (14%)
Query: 125 KAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMA-----------EFYRENEEKS---K 170
+ ++ N L+ E+ + + LKD ++ + Q A E + +E + +
Sbjct: 234 QTLMDNMTLERERES-----EKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQ 288
Query: 171 ELERQKHMCSVLQHKMEELKEGLRQRDE----LIEKHGLVIIPDGTPNG-----DVSHEP 221
EL++ K + L K + L E L ++++ L EKH + D+ +
Sbjct: 289 ELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQ 348
Query: 222 VAGAITVVSQEAAQV-LESAGEGPLDVRLRKLAGEKE----ELLSQIRKLKLQLEEERQ- 275
+ ++ ++ +E + +G +L++ E E L ++ ++L+ Q EE+ Q
Sbjct: 349 LQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQH 408
Query: 276 -------------KCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQD 322
K + +G+ G E D +Q+++ + KLS+ E+
Sbjct: 409 GLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQ 468
Query: 323 ITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHL 382
+ + + L+ Q+ + K + + ++ A+ R+ Q +L L +I + + +L
Sbjct: 469 LKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNL 528
Query: 383 AKRLEKMKANRTAL 396
L+K K N + L
Sbjct: 529 EALLQKSKENISLL 542
Score = 29.3 bits (64), Expect = 6.6
Identities = 46/197 (23%), Positives = 86/197 (43%), Gaps = 28/197 (14%)
Query: 107 TSLSELRESLSEVE-EKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYREN 165
T+L + ++ L + + E KA A ++ EK N LKD ++++EE++ + + E
Sbjct: 1159 TNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQ----QILKDQVKKEEEELKKEFIEK 1214
Query: 166 EEKSKELERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGA 225
E K L +++E + G+++ +E K + I G V E +
Sbjct: 1215 EAK-------------LHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKE-WQSS 1260
Query: 226 ITVVSQEAAQVLESAGE-GPLDVRLRKLAGEKEELL-------SQIRKLKLQLEEERQKC 277
VS+ Q + GE L+ ++ E+ LL +I KL+ ++ E ++K
Sbjct: 1261 QRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKL 1320
Query: 278 SRNDGTVGDLAGLQNGS 294
V +L G +N S
Sbjct: 1321 DNTTAAVQEL-GRENQS 1336
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 57.8 bits (138), Expect = 2e-08
Identities = 89/390 (22%), Positives = 173/390 (44%), Gaps = 43/390 (11%)
Query: 19 AEDEALSNIAR---EAEARLAAKRAARAEARDIRMRELERQQKELDEKSDKQYAE--NYT 73
+E++ + N+ + E+ A++ ++ A RD ++ ELE++ K L E+S Q E +
Sbjct: 774 SEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLL 833
Query: 74 RPSSRNSASATTPLSGNSSRRGSGDTSSL----IDPDTSLSELRESLSEVEEKYKKAMVS 129
R + L S + + + L + T L E + L +VEE + S
Sbjct: 834 RDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRL-ENQNLLIQVEEVSQTC--S 890
Query: 130 NAQLDNEKNN-LIYQVDTLKDVIEEQE--EQMAEFYRENEEKSKELE-RQKHMCSV--LQ 183
+++ NEK I + + LK ++E++E ++ AE + +K + + SV L+
Sbjct: 891 KSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELE 950
Query: 184 HKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLES--AG 241
K+E L++ ++++E I K LV + E +Q + LES +
Sbjct: 951 EKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKE---------TQTVKEELESLRSE 1001
Query: 242 EGPLDVRLRKL---AGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQF 298
+ L +R L A + LL + K QL+ E+++ + + + DL S LQ
Sbjct: 1002 KDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQC 1061
Query: 299 IEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEK 358
+ D ++ I TL+ + LE Q+L + A +K + K +K
Sbjct: 1062 ETINSDNEDLLAR-----------IETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQK 1110
Query: 359 RKLQRELRTALDKIEEMEMTNSHLAKRLEK 388
+ +E T ++++EE+++ K+L+K
Sbjct: 1111 EQKIKEHATTVNELEELQVQLQKEKKQLQK 1140
Score = 45.4 bits (106), Expect = 9e-05
Identities = 82/413 (19%), Positives = 171/413 (41%), Gaps = 57/413 (13%)
Query: 22 EALSNIAREAEARLAAKRAARAEARDIRMRELERQ----QKELDEKSDKQYAENYTRPSS 77
E N+ +E + + + R E +I EL +E + +Q ++ +
Sbjct: 464 EQCENLQQEKQEAILNYESLR-EIMEILQTELGESAGKISQEFESMKQQQASDVHELQQK 522
Query: 78 RNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSEVEEKYKKAMVSNAQ----- 132
+A + R G+ L+ + EL ++ ++EK ++S +Q
Sbjct: 523 LRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTML 582
Query: 133 --LDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENE-------EKSKELERQKHMCSVLQ 183
L+ + N+L + D + ++ E+M F+++ E E K++E+ S L+
Sbjct: 583 KELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELE 642
Query: 184 HKMEE----LKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLES 239
K+ E L+E L+++D+ +K +++ + D V+S E + E
Sbjct: 643 QKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKE---------VLSAEVKSLYEE 693
Query: 240 AGEGPLDVRLRKLAGEKEELLSQ-----IRKLKLQLEEERQKCSRNDGTVGDLAGLQNGS 294
L ++L+ + E LSQ +++ QLE++ Q + L +
Sbjct: 694 --NNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQ 751
Query: 295 DLQFIEMQ-----RDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYK--TAAENA 347
L F++ Q ++ ++SE E+D+ + Q++ ++ K A +
Sbjct: 752 KL-FVKTQLYGFLKEMGSEVSE-----DSEEKDVVNVLQAVGESLAKINEEKCNLAFQRD 805
Query: 348 EKVEDELKAEKRKLQRELRTALDKIEEM----EMTNSHLAKRLEKMKANRTAL 396
EKV EL+ E + LQ E ++++ + E L K LE++++ + AL
Sbjct: 806 EKVL-ELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEAL 857
Score = 40.8 bits (94), Expect = 0.002
Identities = 62/326 (19%), Positives = 133/326 (40%), Gaps = 68/326 (20%)
Query: 114 ESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELE 173
+SL E +K + D+EK L TL I+ +EQ +E +E E
Sbjct: 427 QSLKEQHQKEISELNETFLSDSEKEKL-----TLMFEIQGLKEQCENLQQEKQEAILNYE 481
Query: 174 RQKHMCSVLQHKM----------------------EELKEGLR----QRDELIEKHGLV- 206
+ + +LQ ++ EL++ LR ++D L+E +
Sbjct: 482 SLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQ 541
Query: 207 -----------IIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGE 255
++P+ E + +SQ + E L+ ++ L E
Sbjct: 542 GENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKE------LEGKINSLTEE 595
Query: 256 KEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFK 315
K++ +++++ +++ +KC R + + +L Q I+ + ++++E
Sbjct: 596 KDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVE----QTIQYNSELEQKVNELTGG 651
Query: 316 LSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELK----------AEKRKLQREL 365
L E+ + +Q+ +LE +++ K +E+ E + E+K +EK++L R+L
Sbjct: 652 L---EETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDL 708
Query: 366 RTALDKIEEMEMTN--SHLAKRLEKM 389
L + E++ + + L K+L+ M
Sbjct: 709 EVFLSQKEDVILKEHITQLEKKLQLM 734
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 57.8 bits (138), Expect = 2e-08
Identities = 90/436 (20%), Positives = 181/436 (41%), Gaps = 59/436 (13%)
Query: 13 VKDRFSAEDEALSNIAREAE-ARLAAKRAARAEARDIRMRELERQ--QKELDEKSDKQYA 69
V D+ E EA A EAE AR+ A+R A R + E +Q +++ ++ Q A
Sbjct: 2075 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2134
Query: 70 ENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSEVEEKYKKAMVS 129
R + A+ + R+ + + + ++VE++ +
Sbjct: 2135 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ 2194
Query: 130 NAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEEL 189
+ D++KN L ++ LK E Q ++ EE+ + Q S L+ ++E
Sbjct: 2195 LEETDHQKNLLDEELQRLKAEATEAARQRSQV----EEELFSVRVQMEELSKLKARIEAE 2250
Query: 190 KEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRL 249
L RD+ + + + V+ E A ++V +QEAA++ + A E R
Sbjct: 2251 NRALILRDK--DNTQRFLQEEAEKMKQVAEE--AARLSVAAQEAARLRQLAEEDLAQQRA 2306
Query: 250 --RKLAGEKEELLSQIRKLKLQ-----------------LEEERQKCSRN--DGTVGDLA 288
K+ EK + + + +LK + L+E++++ ++ + T G
Sbjct: 2307 LAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQR 2366
Query: 289 GLQNGSDLQFIEMQRDANR---QISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAE 345
L+ Q +EM +A R +++E ++AE+D + + ++ R + A +
Sbjct: 2367 TLEAERQRQ-LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ 2425
Query: 346 ------------------NAEKVED---ELKAEKRKLQRELRTALDKIEEMEMTNSHLAK 384
+AE++ + EL+ EK KLQ+E + K EEM+ +
Sbjct: 2426 EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE--Q 2483
Query: 385 RLEKMKANRTALLAQQ 400
L++ +A + + L+++
Sbjct: 2484 LLQETQALQQSFLSEK 2499
Score = 57.4 bits (137), Expect = 2e-08
Identities = 86/430 (20%), Positives = 178/430 (41%), Gaps = 41/430 (9%)
Query: 5 ASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELE-----RQQKE 59
A R+ +R + + S R+AE LA++ A AEA + R L+ R Q E
Sbjct: 1487 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1546
Query: 60 LDEKSDKQYAENYTR-------PSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSEL 112
E+ +Q R + R++ + + + + + SL + ++++L
Sbjct: 1547 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1606
Query: 113 RESLSEVEEKYKKAMVSNAQLDNE-------KNNLIYQVDTLKDVIEEQEEQMAEFYREN 165
RE ++ +A + + + E N + ++V +++ AE ++
Sbjct: 1607 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1666
Query: 166 EEKSKELE----------RQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNG 215
EE +E RQ+ + K +L EG Q+ L + L+ + T G
Sbjct: 1667 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ-RLAAEQELIRLRAETEQG 1725
Query: 216 DVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQ----LE 271
+ + + + + +EAA + E L+ L K+ E E LL+ + + + E
Sbjct: 1726 EQQRQLLEEELARLQREAAAATQKRQE--LEAELAKVRAEMEVLLASKARAEEESRSTSE 1783
Query: 272 EERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSIS 331
+ +Q+ G +LA + + L+ + + RQ++E +AE + L + ++
Sbjct: 1784 KSKQRLEAEAGRFRELA--EEAARLRALAEEAKRQRQLAEEDAARQRAEAE-RVLAEKLA 1840
Query: 332 RLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTN-SHLAKRLEKMK 390
+ G+ R KT AE A K ++ R+L + ++EE + + + +RL +++
Sbjct: 1841 AI-GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1899
Query: 391 ANRTALLAQQ 400
+ L +Q
Sbjct: 1900 KASDSELERQ 1909
Score = 55.5 bits (132), Expect = 9e-08
Identities = 94/418 (22%), Positives = 171/418 (40%), Gaps = 40/418 (9%)
Query: 14 KDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMR-ELERQQKELDEKSDKQYAENY 72
+ R AE++A A EAE LA K AA EA ++ E+ ++KE + + ++ AE+
Sbjct: 1815 RQRQLAEEDAARQRA-EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDE 1873
Query: 73 TRPSSRNSASATTPLSGNSSR----RGSGDTSS------LIDPDTSLSELRESLSEVEEK 122
R A + R R + D+ + D ++ E + ++
Sbjct: 1874 AFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKAS 1933
Query: 123 YKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVL 182
++KA A+L+ E + + D + +E+ E R+ + ++E R++ +
Sbjct: 1934 FEKAAAGKAELELELGRIRSNAE---DTLRSKEQAELEAARQRQLAAEEERRRREAEERV 1990
Query: 183 QHKMEELKEGLRQRDELIEK-HGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAG 241
Q + +E RQR +E+ L + E + ++QEAAQ A
Sbjct: 1991 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2050
Query: 242 EGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDL----- 296
E +++ E ++ L Q + + QL E + +R + A +Q +
Sbjct: 2051 EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE-AARRAAEEAEEARVQAEREAAQSRR 2109
Query: 297 ---------QFIEMQRDANRQISEYKFKLSK-AEQDITTLEQSISRLEGQVLRYKTAA-- 344
Q E Q A Q KL K AEQ+ Q+ E LR K AA
Sbjct: 2110 QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA----EQAALRQKQAADA 2165
Query: 345 --ENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ 400
E +K ++ +K ++++EL T ++EE + + L + L+++KA T Q+
Sbjct: 2166 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2223
Score = 54.3 bits (129), Expect = 2e-07
Identities = 91/429 (21%), Positives = 172/429 (40%), Gaps = 46/429 (10%)
Query: 8 RKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELE----RQQKELDEK 63
++R ++R + + AL + AEA AK A EA++++ R E R++ +D +
Sbjct: 1353 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQ 1412
Query: 64 SDKQYAENYTRPSSRNS-----ASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSE 118
K+ + + ++S A A + SR + ++ +E + +E
Sbjct: 1413 QQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAE 1472
Query: 119 VEEKYKKAMVSNA-----QLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELE 173
E + +A A Q E L QV + E ++A + E ++E +
Sbjct: 1473 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1532
Query: 174 RQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEA 233
R L+ + EE + LRQ + +E+ V + T E + +++
Sbjct: 1533 RALQALEELRLQAEEAERRLRQAE--VERARQVQVALETAQRSAEAE-LQSKRASFAEKT 1589
Query: 234 AQVLESAGEGPLDV-RLRKLAGEKEELLSQIRKLKLQLEEE--RQKCSRNDGT------- 283
AQ+ S E + V +LR+ A + + ++ + + + E E R + N+
Sbjct: 1590 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1649
Query: 284 -VGDLAGL-QNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEG------ 335
V L Q ++ Q E +R+A R+ + + + E LE+ EG
Sbjct: 1650 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL 1709
Query: 336 ----QVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKA 391
+++R + E E+ L+ E +LQRE A K +E+E L K++A
Sbjct: 1710 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE-------AELAKVRA 1762
Query: 392 NRTALLAQQ 400
LLA +
Sbjct: 1763 EMEVLLASK 1771
Score = 45.4 bits (106), Expect = 9e-05
Identities = 86/434 (19%), Positives = 159/434 (36%), Gaps = 47/434 (10%)
Query: 5 ASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKELDEKS 64
AS ++T +R E+ RE R A ++A AR+ RELER Q + +E
Sbjct: 1583 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1642
Query: 65 D-KQYAENYTRPSSRNSASA---TTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSEVE 120
+ AE + S A A + RRG + ++ + + EL + E
Sbjct: 1643 RLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAE 1702
Query: 121 EKYKKAMVSNAQLDN---EKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKH 177
++ + + +L E Q L++ + + + A ++ +E EL + +
Sbjct: 1703 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA 1762
Query: 178 MCSVL-------QHKMEELKEGLRQR--------DELIEKHGLV--IIPDGTPNGDVSHE 220
VL + + E +QR EL E+ + + + ++ E
Sbjct: 1763 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1822
Query: 221 PVAGAITVVSQEAAQVLESAGEG-----PLDVRLRKLAGEKEELLSQIRKLKLQLEEERQ 275
A + A+ L + GE ++ L++ E E L Q +
Sbjct: 1823 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1882
Query: 276 KCSRNDGTVGD-LAGLQNGSDLQF----------IEMQRDANRQISEYKFKLSKAEQDIT 324
+ +++ + + LA L+ SD + + +R +I K KA
Sbjct: 1883 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1942
Query: 325 TLEQSISRLEG---QVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKI----EEMEM 377
LE + R+ LR K AE + +L AE+ + +RE + K EE
Sbjct: 1943 ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 2002
Query: 378 TNSHLAKRLEKMKA 391
+ +E++KA
Sbjct: 2003 QRKAALEEVERLKA 2016
Score = 38.5 bits (88), Expect = 0.011
Identities = 84/398 (21%), Positives = 155/398 (38%), Gaps = 49/398 (12%)
Query: 29 REAEARLAAKRAARAEARDIRMRELE---RQQKELDEKSDK--QYAENYTRPSSRNSASA 83
RE A+L + A D+R RELE RQ + E +D + ++ R R
Sbjct: 1178 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR---RQEQIQ 1234
Query: 84 TTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSEVEE--KYKKAMVSNAQLDNEKNNLI 141
PL+ + + R L L E+ +VEE ++ K + NA D E +
Sbjct: 1235 AMPLADSQAVR-----EQLRQEQALLEEIERHGEKVEECQRFAKQYI-NAIKDYELQLVT 1288
Query: 142 YQVD-------TLKDVIEEQEEQMAEFYRENEEKSKEL-----ERQKHMCSVLQHKMEEL 189
Y+ K ++ E + + Y + EL + K + L+ EE
Sbjct: 1289 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1348
Query: 190 KEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRL 249
+ +QR E E+ L + E A A +EA ++ + E +V
Sbjct: 1349 RLAEQQRAE--ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE---EVVR 1403
Query: 250 RKLAG-----EKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRD 304
R+ A +K + ++++L+ E E Q +R + + L+ +++ + +Q +
Sbjct: 1404 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR-QAEAAERSRLRIEEEIRVVRLQLE 1462
Query: 305 ANR--------QISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAE-KVEDELK 355
A ++ + + +AE ++ RL QV AE ++ +K
Sbjct: 1463 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1522
Query: 356 AEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANR 393
AE + RE + AL +EE+ + +RL + + R
Sbjct: 1523 AE-AEAAREKQRALQALEELRLQAEEAERRLRQAEVER 1559
Score = 32.3 bits (72), Expect = 0.78
Identities = 61/299 (20%), Positives = 122/299 (40%), Gaps = 30/299 (10%)
Query: 108 SLSELRESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEE 167
+L EL + + +++ +A D ++ L + + + + E+ E R E
Sbjct: 1121 TLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER 1180
Query: 168 KSKELERQKHMCS---VLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAG 224
++ LER + + + V Q ++E+L LR E + G + + P+A
Sbjct: 1181 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD 1240
Query: 225 AITV---VSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRND 281
+ V + QE A + E G ++ A ++ ++ I+ +LQL + +
Sbjct: 1241 SQAVREQLRQEQALLEEIERHGEKVEECQRFA---KQYINAIKDYELQLVTYKAQLE--- 1294
Query: 282 GTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYK 341
S + ++Q + I EY L ++TTL + + LR
Sbjct: 1295 ---------PVASPAKKPKVQSGSESVIQEY-VDLRTHYSELTTLTSQYIKFISETLR-- 1342
Query: 342 TAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ 400
E E++ ++ +AE+R+ E+ AL+K + ++ +H K +A R A QQ
Sbjct: 1343 -RMEEEERLAEQQRAEERERLAEVEAALEK--QRQLAEAHAQ---AKAQAEREAKELQQ 1395
Score = 30.8 bits (68), Expect = 2.3
Identities = 34/179 (18%), Positives = 83/179 (46%), Gaps = 19/179 (10%)
Query: 113 RESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKEL 172
++ +++ ++ ++ Q++ E+ L+ ++ + E EE + R +E+ ++L
Sbjct: 2521 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV----RRKQEELQQL 2576
Query: 173 ERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQE 232
E+Q+ L + E + LR++ +L+E+ + + +V+ VA T+ +
Sbjct: 2577 EQQRRQQEEL---LAEENQRLREQLQLLEEQHRAAL---AHSEEVTASQVAATKTLPNGR 2630
Query: 233 AA---QVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLA 288
A E+ E D RK++ ++ +++ + EE Q+ ++ TV +LA
Sbjct: 2631 DALDGPAAEAEPEHSFDGLRRKVSAQR------LQEAGILSAEELQRLAQGHTTVDELA 2683
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 57.8 bits (138), Expect = 2e-08
Identities = 90/436 (20%), Positives = 181/436 (41%), Gaps = 59/436 (13%)
Query: 13 VKDRFSAEDEALSNIAREAE-ARLAAKRAARAEARDIRMRELERQ--QKELDEKSDKQYA 69
V D+ E EA A EAE AR+ A+R A R + E +Q +++ ++ Q A
Sbjct: 2079 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2138
Query: 70 ENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSEVEEKYKKAMVS 129
R + A+ + R+ + + + ++VE++ +
Sbjct: 2139 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ 2198
Query: 130 NAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEEL 189
+ D++KN L ++ LK E Q ++ EE+ + Q S L+ ++E
Sbjct: 2199 LEETDHQKNLLDEELQRLKAEATEAARQRSQV----EEELFSVRVQMEELSKLKARIEAE 2254
Query: 190 KEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRL 249
L RD+ + + + V+ E A ++V +QEAA++ + A E R
Sbjct: 2255 NRALILRDK--DNTQRFLQEEAEKMKQVAEE--AARLSVAAQEAARLRQLAEEDLAQQRA 2310
Query: 250 --RKLAGEKEELLSQIRKLKLQ-----------------LEEERQKCSRN--DGTVGDLA 288
K+ EK + + + +LK + L+E++++ ++ + T G
Sbjct: 2311 LAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQR 2370
Query: 289 GLQNGSDLQFIEMQRDANR---QISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAE 345
L+ Q +EM +A R +++E ++AE+D + + ++ R + A +
Sbjct: 2371 TLEAERQRQ-LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ 2429
Query: 346 ------------------NAEKVED---ELKAEKRKLQRELRTALDKIEEMEMTNSHLAK 384
+AE++ + EL+ EK KLQ+E + K EEM+ +
Sbjct: 2430 EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE--Q 2487
Query: 385 RLEKMKANRTALLAQQ 400
L++ +A + + L+++
Sbjct: 2488 LLQETQALQQSFLSEK 2503
Score = 57.4 bits (137), Expect = 2e-08
Identities = 86/430 (20%), Positives = 178/430 (41%), Gaps = 41/430 (9%)
Query: 5 ASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELE-----RQQKE 59
A R+ +R + + S R+AE LA++ A AEA + R L+ R Q E
Sbjct: 1491 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1550
Query: 60 LDEKSDKQYAENYTR-------PSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSEL 112
E+ +Q R + R++ + + + + + SL + ++++L
Sbjct: 1551 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1610
Query: 113 RESLSEVEEKYKKAMVSNAQLDNE-------KNNLIYQVDTLKDVIEEQEEQMAEFYREN 165
RE ++ +A + + + E N + ++V +++ AE ++
Sbjct: 1611 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1670
Query: 166 EEKSKELE----------RQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNG 215
EE +E RQ+ + K +L EG Q+ L + L+ + T G
Sbjct: 1671 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ-RLAAEQELIRLRAETEQG 1729
Query: 216 DVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQ----LE 271
+ + + + + +EAA + E L+ L K+ E E LL+ + + + E
Sbjct: 1730 EQQRQLLEEELARLQREAAAATQKRQE--LEAELAKVRAEMEVLLASKARAEEESRSTSE 1787
Query: 272 EERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSIS 331
+ +Q+ G +LA + + L+ + + RQ++E +AE + L + ++
Sbjct: 1788 KSKQRLEAEAGRFRELA--EEAARLRALAEEAKRQRQLAEEDAARQRAEAE-RVLAEKLA 1844
Query: 332 RLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTN-SHLAKRLEKMK 390
+ G+ R KT AE A K ++ R+L + ++EE + + + +RL +++
Sbjct: 1845 AI-GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1903
Query: 391 ANRTALLAQQ 400
+ L +Q
Sbjct: 1904 KASDSELERQ 1913
Score = 55.5 bits (132), Expect = 9e-08
Identities = 94/418 (22%), Positives = 171/418 (40%), Gaps = 40/418 (9%)
Query: 14 KDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMR-ELERQQKELDEKSDKQYAENY 72
+ R AE++A A EAE LA K AA EA ++ E+ ++KE + + ++ AE+
Sbjct: 1819 RQRQLAEEDAARQRA-EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDE 1877
Query: 73 TRPSSRNSASATTPLSGNSSR----RGSGDTSS------LIDPDTSLSELRESLSEVEEK 122
R A + R R + D+ + D ++ E + ++
Sbjct: 1878 AFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKAS 1937
Query: 123 YKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVL 182
++KA A+L+ E + + D + +E+ E R+ + ++E R++ +
Sbjct: 1938 FEKAAAGKAELELELGRIRSNAE---DTLRSKEQAELEAARQRQLAAEEERRRREAEERV 1994
Query: 183 QHKMEELKEGLRQRDELIEK-HGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAG 241
Q + +E RQR +E+ L + E + ++QEAAQ A
Sbjct: 1995 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2054
Query: 242 EGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDL----- 296
E +++ E ++ L Q + + QL E + +R + A +Q +
Sbjct: 2055 EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE-AARRAAEEAEEARVQAEREAAQSRR 2113
Query: 297 ---------QFIEMQRDANRQISEYKFKLSK-AEQDITTLEQSISRLEGQVLRYKTAA-- 344
Q E Q A Q KL K AEQ+ Q+ E LR K AA
Sbjct: 2114 QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA----EQAALRQKQAADA 2169
Query: 345 --ENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ 400
E +K ++ +K ++++EL T ++EE + + L + L+++KA T Q+
Sbjct: 2170 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2227
Score = 54.3 bits (129), Expect = 2e-07
Identities = 91/429 (21%), Positives = 172/429 (40%), Gaps = 46/429 (10%)
Query: 8 RKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELE----RQQKELDEK 63
++R ++R + + AL + AEA AK A EA++++ R E R++ +D +
Sbjct: 1357 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQ 1416
Query: 64 SDKQYAENYTRPSSRNS-----ASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSE 118
K+ + + ++S A A + SR + ++ +E + +E
Sbjct: 1417 QQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAE 1476
Query: 119 VEEKYKKAMVSNA-----QLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELE 173
E + +A A Q E L QV + E ++A + E ++E +
Sbjct: 1477 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1536
Query: 174 RQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEA 233
R L+ + EE + LRQ + +E+ V + T E + +++
Sbjct: 1537 RALQALEELRLQAEEAERRLRQAE--VERARQVQVALETAQRSAEAE-LQSKRASFAEKT 1593
Query: 234 AQVLESAGEGPLDV-RLRKLAGEKEELLSQIRKLKLQLEEE--RQKCSRNDGT------- 283
AQ+ S E + V +LR+ A + + ++ + + + E E R + N+
Sbjct: 1594 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1653
Query: 284 -VGDLAGL-QNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEG------ 335
V L Q ++ Q E +R+A R+ + + + E LE+ EG
Sbjct: 1654 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL 1713
Query: 336 ----QVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKA 391
+++R + E E+ L+ E +LQRE A K +E+E L K++A
Sbjct: 1714 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE-------AELAKVRA 1766
Query: 392 NRTALLAQQ 400
LLA +
Sbjct: 1767 EMEVLLASK 1775
Score = 45.4 bits (106), Expect = 9e-05
Identities = 86/434 (19%), Positives = 159/434 (36%), Gaps = 47/434 (10%)
Query: 5 ASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKELDEKS 64
AS ++T +R E+ RE R A ++A AR+ RELER Q + +E
Sbjct: 1587 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1646
Query: 65 D-KQYAENYTRPSSRNSASA---TTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSEVE 120
+ AE + S A A + RRG + ++ + + EL + E
Sbjct: 1647 RLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAE 1706
Query: 121 EKYKKAMVSNAQLDN---EKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKH 177
++ + + +L E Q L++ + + + A ++ +E EL + +
Sbjct: 1707 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA 1766
Query: 178 MCSVL-------QHKMEELKEGLRQR--------DELIEKHGLV--IIPDGTPNGDVSHE 220
VL + + E +QR EL E+ + + + ++ E
Sbjct: 1767 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1826
Query: 221 PVAGAITVVSQEAAQVLESAGEG-----PLDVRLRKLAGEKEELLSQIRKLKLQLEEERQ 275
A + A+ L + GE ++ L++ E E L Q +
Sbjct: 1827 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1886
Query: 276 KCSRNDGTVGD-LAGLQNGSDLQF----------IEMQRDANRQISEYKFKLSKAEQDIT 324
+ +++ + + LA L+ SD + + +R +I K KA
Sbjct: 1887 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1946
Query: 325 TLEQSISRLEG---QVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKI----EEMEM 377
LE + R+ LR K AE + +L AE+ + +RE + K EE
Sbjct: 1947 ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 2006
Query: 378 TNSHLAKRLEKMKA 391
+ +E++KA
Sbjct: 2007 QRKAALEEVERLKA 2020
Score = 38.5 bits (88), Expect = 0.011
Identities = 84/398 (21%), Positives = 155/398 (38%), Gaps = 49/398 (12%)
Query: 29 REAEARLAAKRAARAEARDIRMRELE---RQQKELDEKSDK--QYAENYTRPSSRNSASA 83
RE A+L + A D+R RELE RQ + E +D + ++ R R
Sbjct: 1182 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR---RQEQIQ 1238
Query: 84 TTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSEVEE--KYKKAMVSNAQLDNEKNNLI 141
PL+ + + R L L E+ +VEE ++ K + NA D E +
Sbjct: 1239 AMPLADSQAVR-----EQLRQEQALLEEIERHGEKVEECQRFAKQYI-NAIKDYELQLVT 1292
Query: 142 YQVD-------TLKDVIEEQEEQMAEFYRENEEKSKEL-----ERQKHMCSVLQHKMEEL 189
Y+ K ++ E + + Y + EL + K + L+ EE
Sbjct: 1293 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1352
Query: 190 KEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRL 249
+ +QR E E+ L + E A A +EA ++ + E +V
Sbjct: 1353 RLAEQQRAE--ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE---EVVR 1407
Query: 250 RKLAG-----EKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRD 304
R+ A +K + ++++L+ E E Q +R + + L+ +++ + +Q +
Sbjct: 1408 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR-QAEAAERSRLRIEEEIRVVRLQLE 1466
Query: 305 ANR--------QISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAE-KVEDELK 355
A ++ + + +AE ++ RL QV AE ++ +K
Sbjct: 1467 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1526
Query: 356 AEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANR 393
AE + RE + AL +EE+ + +RL + + R
Sbjct: 1527 AE-AEAAREKQRALQALEELRLQAEEAERRLRQAEVER 1563
Score = 32.3 bits (72), Expect = 0.78
Identities = 61/299 (20%), Positives = 122/299 (40%), Gaps = 30/299 (10%)
Query: 108 SLSELRESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEE 167
+L EL + + +++ +A D ++ L + + + + E+ E R E
Sbjct: 1125 TLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER 1184
Query: 168 KSKELERQKHMCS---VLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAG 224
++ LER + + + V Q ++E+L LR E + G + + P+A
Sbjct: 1185 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD 1244
Query: 225 AITV---VSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRND 281
+ V + QE A + E G ++ A ++ ++ I+ +LQL + +
Sbjct: 1245 SQAVREQLRQEQALLEEIERHGEKVEECQRFA---KQYINAIKDYELQLVTYKAQLE--- 1298
Query: 282 GTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYK 341
S + ++Q + I EY L ++TTL + + LR
Sbjct: 1299 ---------PVASPAKKPKVQSGSESVIQEY-VDLRTHYSELTTLTSQYIKFISETLR-- 1346
Query: 342 TAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ 400
E E++ ++ +AE+R+ E+ AL+K + ++ +H K +A R A QQ
Sbjct: 1347 -RMEEEERLAEQQRAEERERLAEVEAALEK--QRQLAEAHAQ---AKAQAEREAKELQQ 1399
Score = 30.8 bits (68), Expect = 2.3
Identities = 34/179 (18%), Positives = 83/179 (46%), Gaps = 19/179 (10%)
Query: 113 RESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKEL 172
++ +++ ++ ++ Q++ E+ L+ ++ + E EE + R +E+ ++L
Sbjct: 2525 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV----RRKQEELQQL 2580
Query: 173 ERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQE 232
E+Q+ L + E + LR++ +L+E+ + + +V+ VA T+ +
Sbjct: 2581 EQQRRQQEEL---LAEENQRLREQLQLLEEQHRAAL---AHSEEVTASQVAATKTLPNGR 2634
Query: 233 AA---QVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLA 288
A E+ E D RK++ ++ +++ + EE Q+ ++ TV +LA
Sbjct: 2635 DALDGPAAEAEPEHSFDGLRRKVSAQR------LQEAGILSAEELQRLAQGHTTVDELA 2687
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 57.8 bits (138), Expect = 2e-08
Identities = 90/436 (20%), Positives = 181/436 (41%), Gaps = 59/436 (13%)
Query: 13 VKDRFSAEDEALSNIAREAE-ARLAAKRAARAEARDIRMRELERQ--QKELDEKSDKQYA 69
V D+ E EA A EAE AR+ A+R A R + E +Q +++ ++ Q A
Sbjct: 2075 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2134
Query: 70 ENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSEVEEKYKKAMVS 129
R + A+ + R+ + + + ++VE++ +
Sbjct: 2135 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ 2194
Query: 130 NAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEEL 189
+ D++KN L ++ LK E Q ++ EE+ + Q S L+ ++E
Sbjct: 2195 LEETDHQKNLLDEELQRLKAEATEAARQRSQV----EEELFSVRVQMEELSKLKARIEAE 2250
Query: 190 KEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRL 249
L RD+ + + + V+ E A ++V +QEAA++ + A E R
Sbjct: 2251 NRALILRDK--DNTQRFLQEEAEKMKQVAEE--AARLSVAAQEAARLRQLAEEDLAQQRA 2306
Query: 250 --RKLAGEKEELLSQIRKLKLQ-----------------LEEERQKCSRN--DGTVGDLA 288
K+ EK + + + +LK + L+E++++ ++ + T G
Sbjct: 2307 LAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQR 2366
Query: 289 GLQNGSDLQFIEMQRDANR---QISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAE 345
L+ Q +EM +A R +++E ++AE+D + + ++ R + A +
Sbjct: 2367 TLEAERQRQ-LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ 2425
Query: 346 ------------------NAEKVED---ELKAEKRKLQRELRTALDKIEEMEMTNSHLAK 384
+AE++ + EL+ EK KLQ+E + K EEM+ +
Sbjct: 2426 EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE--Q 2483
Query: 385 RLEKMKANRTALLAQQ 400
L++ +A + + L+++
Sbjct: 2484 LLQETQALQQSFLSEK 2499
Score = 57.4 bits (137), Expect = 2e-08
Identities = 86/430 (20%), Positives = 178/430 (41%), Gaps = 41/430 (9%)
Query: 5 ASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELE-----RQQKE 59
A R+ +R + + S R+AE LA++ A AEA + R L+ R Q E
Sbjct: 1487 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1546
Query: 60 LDEKSDKQYAENYTR-------PSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSEL 112
E+ +Q R + R++ + + + + + SL + ++++L
Sbjct: 1547 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1606
Query: 113 RESLSEVEEKYKKAMVSNAQLDNE-------KNNLIYQVDTLKDVIEEQEEQMAEFYREN 165
RE ++ +A + + + E N + ++V +++ AE ++
Sbjct: 1607 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1666
Query: 166 EEKSKELE----------RQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNG 215
EE +E RQ+ + K +L EG Q+ L + L+ + T G
Sbjct: 1667 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ-RLAAEQELIRLRAETEQG 1725
Query: 216 DVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQ----LE 271
+ + + + + +EAA + E L+ L K+ E E LL+ + + + E
Sbjct: 1726 EQQRQLLEEELARLQREAAAATQKRQE--LEAELAKVRAEMEVLLASKARAEEESRSTSE 1783
Query: 272 EERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSIS 331
+ +Q+ G +LA + + L+ + + RQ++E +AE + L + ++
Sbjct: 1784 KSKQRLEAEAGRFRELA--EEAARLRALAEEAKRQRQLAEEDAARQRAEAE-RVLAEKLA 1840
Query: 332 RLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTN-SHLAKRLEKMK 390
+ G+ R KT AE A K ++ R+L + ++EE + + + +RL +++
Sbjct: 1841 AI-GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1899
Query: 391 ANRTALLAQQ 400
+ L +Q
Sbjct: 1900 KASDSELERQ 1909
Score = 55.5 bits (132), Expect = 9e-08
Identities = 94/418 (22%), Positives = 171/418 (40%), Gaps = 40/418 (9%)
Query: 14 KDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMR-ELERQQKELDEKSDKQYAENY 72
+ R AE++A A EAE LA K AA EA ++ E+ ++KE + + ++ AE+
Sbjct: 1815 RQRQLAEEDAARQRA-EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDE 1873
Query: 73 TRPSSRNSASATTPLSGNSSR----RGSGDTSS------LIDPDTSLSELRESLSEVEEK 122
R A + R R + D+ + D ++ E + ++
Sbjct: 1874 AFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKAS 1933
Query: 123 YKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVL 182
++KA A+L+ E + + D + +E+ E R+ + ++E R++ +
Sbjct: 1934 FEKAAAGKAELELELGRIRSNAE---DTLRSKEQAELEAARQRQLAAEEERRRREAEERV 1990
Query: 183 QHKMEELKEGLRQRDELIEK-HGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAG 241
Q + +E RQR +E+ L + E + ++QEAAQ A
Sbjct: 1991 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2050
Query: 242 EGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDL----- 296
E +++ E ++ L Q + + QL E + +R + A +Q +
Sbjct: 2051 EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE-AARRAAEEAEEARVQAEREAAQSRR 2109
Query: 297 ---------QFIEMQRDANRQISEYKFKLSK-AEQDITTLEQSISRLEGQVLRYKTAA-- 344
Q E Q A Q KL K AEQ+ Q+ E LR K AA
Sbjct: 2110 QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA----EQAALRQKQAADA 2165
Query: 345 --ENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ 400
E +K ++ +K ++++EL T ++EE + + L + L+++KA T Q+
Sbjct: 2166 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2223
Score = 54.3 bits (129), Expect = 2e-07
Identities = 91/429 (21%), Positives = 172/429 (40%), Gaps = 46/429 (10%)
Query: 8 RKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELE----RQQKELDEK 63
++R ++R + + AL + AEA AK A EA++++ R E R++ +D +
Sbjct: 1353 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQ 1412
Query: 64 SDKQYAENYTRPSSRNS-----ASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSE 118
K+ + + ++S A A + SR + ++ +E + +E
Sbjct: 1413 QQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAE 1472
Query: 119 VEEKYKKAMVSNA-----QLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELE 173
E + +A A Q E L QV + E ++A + E ++E +
Sbjct: 1473 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1532
Query: 174 RQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEA 233
R L+ + EE + LRQ + +E+ V + T E + +++
Sbjct: 1533 RALQALEELRLQAEEAERRLRQAE--VERARQVQVALETAQRSAEAE-LQSKRASFAEKT 1589
Query: 234 AQVLESAGEGPLDV-RLRKLAGEKEELLSQIRKLKLQLEEE--RQKCSRNDGT------- 283
AQ+ S E + V +LR+ A + + ++ + + + E E R + N+
Sbjct: 1590 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1649
Query: 284 -VGDLAGL-QNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEG------ 335
V L Q ++ Q E +R+A R+ + + + E LE+ EG
Sbjct: 1650 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL 1709
Query: 336 ----QVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKA 391
+++R + E E+ L+ E +LQRE A K +E+E L K++A
Sbjct: 1710 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE-------AELAKVRA 1762
Query: 392 NRTALLAQQ 400
LLA +
Sbjct: 1763 EMEVLLASK 1771
Score = 45.4 bits (106), Expect = 9e-05
Identities = 86/434 (19%), Positives = 159/434 (36%), Gaps = 47/434 (10%)
Query: 5 ASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKELDEKS 64
AS ++T +R E+ RE R A ++A AR+ RELER Q + +E
Sbjct: 1583 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1642
Query: 65 D-KQYAENYTRPSSRNSASA---TTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSEVE 120
+ AE + S A A + RRG + ++ + + EL + E
Sbjct: 1643 RLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAE 1702
Query: 121 EKYKKAMVSNAQLDN---EKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKH 177
++ + + +L E Q L++ + + + A ++ +E EL + +
Sbjct: 1703 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA 1762
Query: 178 MCSVL-------QHKMEELKEGLRQR--------DELIEKHGLV--IIPDGTPNGDVSHE 220
VL + + E +QR EL E+ + + + ++ E
Sbjct: 1763 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1822
Query: 221 PVAGAITVVSQEAAQVLESAGEG-----PLDVRLRKLAGEKEELLSQIRKLKLQLEEERQ 275
A + A+ L + GE ++ L++ E E L Q +
Sbjct: 1823 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1882
Query: 276 KCSRNDGTVGD-LAGLQNGSDLQF----------IEMQRDANRQISEYKFKLSKAEQDIT 324
+ +++ + + LA L+ SD + + +R +I K KA
Sbjct: 1883 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1942
Query: 325 TLEQSISRLEG---QVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKI----EEMEM 377
LE + R+ LR K AE + +L AE+ + +RE + K EE
Sbjct: 1943 ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 2002
Query: 378 TNSHLAKRLEKMKA 391
+ +E++KA
Sbjct: 2003 QRKAALEEVERLKA 2016
Score = 38.5 bits (88), Expect = 0.011
Identities = 84/398 (21%), Positives = 155/398 (38%), Gaps = 49/398 (12%)
Query: 29 REAEARLAAKRAARAEARDIRMRELE---RQQKELDEKSDK--QYAENYTRPSSRNSASA 83
RE A+L + A D+R RELE RQ + E +D + ++ R R
Sbjct: 1178 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR---RQEQIQ 1234
Query: 84 TTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSEVEE--KYKKAMVSNAQLDNEKNNLI 141
PL+ + + R L L E+ +VEE ++ K + NA D E +
Sbjct: 1235 AMPLADSQAVR-----EQLRQEQALLEEIERHGEKVEECQRFAKQYI-NAIKDYELQLVT 1288
Query: 142 YQVD-------TLKDVIEEQEEQMAEFYRENEEKSKEL-----ERQKHMCSVLQHKMEEL 189
Y+ K ++ E + + Y + EL + K + L+ EE
Sbjct: 1289 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1348
Query: 190 KEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRL 249
+ +QR E E+ L + E A A +EA ++ + E +V
Sbjct: 1349 RLAEQQRAE--ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE---EVVR 1403
Query: 250 RKLAG-----EKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRD 304
R+ A +K + ++++L+ E E Q +R + + L+ +++ + +Q +
Sbjct: 1404 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR-QAEAAERSRLRIEEEIRVVRLQLE 1462
Query: 305 ANR--------QISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAE-KVEDELK 355
A ++ + + +AE ++ RL QV AE ++ +K
Sbjct: 1463 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1522
Query: 356 AEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANR 393
AE + RE + AL +EE+ + +RL + + R
Sbjct: 1523 AE-AEAAREKQRALQALEELRLQAEEAERRLRQAEVER 1559
Score = 32.3 bits (72), Expect = 0.78
Identities = 61/299 (20%), Positives = 122/299 (40%), Gaps = 30/299 (10%)
Query: 108 SLSELRESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEE 167
+L EL + + +++ +A D ++ L + + + + E+ E R E
Sbjct: 1121 TLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER 1180
Query: 168 KSKELERQKHMCS---VLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAG 224
++ LER + + + V Q ++E+L LR E + G + + P+A
Sbjct: 1181 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD 1240
Query: 225 AITV---VSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRND 281
+ V + QE A + E G ++ A ++ ++ I+ +LQL + +
Sbjct: 1241 SQAVREQLRQEQALLEEIERHGEKVEECQRFA---KQYINAIKDYELQLVTYKAQLE--- 1294
Query: 282 GTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYK 341
S + ++Q + I EY L ++TTL + + LR
Sbjct: 1295 ---------PVASPAKKPKVQSGSESVIQEY-VDLRTHYSELTTLTSQYIKFISETLR-- 1342
Query: 342 TAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ 400
E E++ ++ +AE+R+ E+ AL+K + ++ +H K +A R A QQ
Sbjct: 1343 -RMEEEERLAEQQRAEERERLAEVEAALEK--QRQLAEAHAQ---AKAQAEREAKELQQ 1395
Score = 30.8 bits (68), Expect = 2.3
Identities = 34/179 (18%), Positives = 83/179 (46%), Gaps = 19/179 (10%)
Query: 113 RESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKEL 172
++ +++ ++ ++ Q++ E+ L+ ++ + E EE + R +E+ ++L
Sbjct: 2521 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV----RRKQEELQQL 2576
Query: 173 ERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQE 232
E+Q+ L + E + LR++ +L+E+ + + +V+ VA T+ +
Sbjct: 2577 EQQRRQQEEL---LAEENQRLREQLQLLEEQHRAAL---AHSEEVTASQVAATKTLPNGR 2630
Query: 233 AA---QVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLA 288
A E+ E D RK++ ++ +++ + EE Q+ ++ TV +LA
Sbjct: 2631 DALDGPAAEAEPEHSFDGLRRKVSAQR------LQEAGILSAEELQRLAQGHTTVDELA 2683
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 57.8 bits (138), Expect = 2e-08
Identities = 90/436 (20%), Positives = 181/436 (41%), Gaps = 59/436 (13%)
Query: 13 VKDRFSAEDEALSNIAREAE-ARLAAKRAARAEARDIRMRELERQ--QKELDEKSDKQYA 69
V D+ E EA A EAE AR+ A+R A R + E +Q +++ ++ Q A
Sbjct: 2043 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2102
Query: 70 ENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSEVEEKYKKAMVS 129
R + A+ + R+ + + + ++VE++ +
Sbjct: 2103 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ 2162
Query: 130 NAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEEL 189
+ D++KN L ++ LK E Q ++ EE+ + Q S L+ ++E
Sbjct: 2163 LEETDHQKNLLDEELQRLKAEATEAARQRSQV----EEELFSVRVQMEELSKLKARIEAE 2218
Query: 190 KEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRL 249
L RD+ + + + V+ E A ++V +QEAA++ + A E R
Sbjct: 2219 NRALILRDK--DNTQRFLQEEAEKMKQVAEE--AARLSVAAQEAARLRQLAEEDLAQQRA 2274
Query: 250 --RKLAGEKEELLSQIRKLKLQ-----------------LEEERQKCSRN--DGTVGDLA 288
K+ EK + + + +LK + L+E++++ ++ + T G
Sbjct: 2275 LAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQR 2334
Query: 289 GLQNGSDLQFIEMQRDANR---QISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAE 345
L+ Q +EM +A R +++E ++AE+D + + ++ R + A +
Sbjct: 2335 TLEAERQRQ-LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ 2393
Query: 346 ------------------NAEKVED---ELKAEKRKLQRELRTALDKIEEMEMTNSHLAK 384
+AE++ + EL+ EK KLQ+E + K EEM+ +
Sbjct: 2394 EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE--Q 2451
Query: 385 RLEKMKANRTALLAQQ 400
L++ +A + + L+++
Sbjct: 2452 LLQETQALQQSFLSEK 2467
Score = 57.4 bits (137), Expect = 2e-08
Identities = 86/430 (20%), Positives = 178/430 (41%), Gaps = 41/430 (9%)
Query: 5 ASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELE-----RQQKE 59
A R+ +R + + S R+AE LA++ A AEA + R L+ R Q E
Sbjct: 1455 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1514
Query: 60 LDEKSDKQYAENYTR-------PSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSEL 112
E+ +Q R + R++ + + + + + SL + ++++L
Sbjct: 1515 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1574
Query: 113 RESLSEVEEKYKKAMVSNAQLDNE-------KNNLIYQVDTLKDVIEEQEEQMAEFYREN 165
RE ++ +A + + + E N + ++V +++ AE ++
Sbjct: 1575 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1634
Query: 166 EEKSKELE----------RQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNG 215
EE +E RQ+ + K +L EG Q+ L + L+ + T G
Sbjct: 1635 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ-RLAAEQELIRLRAETEQG 1693
Query: 216 DVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQ----LE 271
+ + + + + +EAA + E L+ L K+ E E LL+ + + + E
Sbjct: 1694 EQQRQLLEEELARLQREAAAATQKRQE--LEAELAKVRAEMEVLLASKARAEEESRSTSE 1751
Query: 272 EERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSIS 331
+ +Q+ G +LA + + L+ + + RQ++E +AE + L + ++
Sbjct: 1752 KSKQRLEAEAGRFRELA--EEAARLRALAEEAKRQRQLAEEDAARQRAEAE-RVLAEKLA 1808
Query: 332 RLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTN-SHLAKRLEKMK 390
+ G+ R KT AE A K ++ R+L + ++EE + + + +RL +++
Sbjct: 1809 AI-GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1867
Query: 391 ANRTALLAQQ 400
+ L +Q
Sbjct: 1868 KASDSELERQ 1877
Score = 55.5 bits (132), Expect = 9e-08
Identities = 94/418 (22%), Positives = 171/418 (40%), Gaps = 40/418 (9%)
Query: 14 KDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMR-ELERQQKELDEKSDKQYAENY 72
+ R AE++A A EAE LA K AA EA ++ E+ ++KE + + ++ AE+
Sbjct: 1783 RQRQLAEEDAARQRA-EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDE 1841
Query: 73 TRPSSRNSASATTPLSGNSSR----RGSGDTSS------LIDPDTSLSELRESLSEVEEK 122
R A + R R + D+ + D ++ E + ++
Sbjct: 1842 AFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKAS 1901
Query: 123 YKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVL 182
++KA A+L+ E + + D + +E+ E R+ + ++E R++ +
Sbjct: 1902 FEKAAAGKAELELELGRIRSNAE---DTLRSKEQAELEAARQRQLAAEEERRRREAEERV 1958
Query: 183 QHKMEELKEGLRQRDELIEK-HGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAG 241
Q + +E RQR +E+ L + E + ++QEAAQ A
Sbjct: 1959 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2018
Query: 242 EGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDL----- 296
E +++ E ++ L Q + + QL E + +R + A +Q +
Sbjct: 2019 EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE-AARRAAEEAEEARVQAEREAAQSRR 2077
Query: 297 ---------QFIEMQRDANRQISEYKFKLSK-AEQDITTLEQSISRLEGQVLRYKTAA-- 344
Q E Q A Q KL K AEQ+ Q+ E LR K AA
Sbjct: 2078 QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA----EQAALRQKQAADA 2133
Query: 345 --ENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ 400
E +K ++ +K ++++EL T ++EE + + L + L+++KA T Q+
Sbjct: 2134 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2191
Score = 54.3 bits (129), Expect = 2e-07
Identities = 91/429 (21%), Positives = 172/429 (40%), Gaps = 46/429 (10%)
Query: 8 RKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELE----RQQKELDEK 63
++R ++R + + AL + AEA AK A EA++++ R E R++ +D +
Sbjct: 1321 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQ 1380
Query: 64 SDKQYAENYTRPSSRNS-----ASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSE 118
K+ + + ++S A A + SR + ++ +E + +E
Sbjct: 1381 QQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAE 1440
Query: 119 VEEKYKKAMVSNA-----QLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELE 173
E + +A A Q E L QV + E ++A + E ++E +
Sbjct: 1441 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1500
Query: 174 RQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEA 233
R L+ + EE + LRQ + +E+ V + T E + +++
Sbjct: 1501 RALQALEELRLQAEEAERRLRQAE--VERARQVQVALETAQRSAEAE-LQSKRASFAEKT 1557
Query: 234 AQVLESAGEGPLDV-RLRKLAGEKEELLSQIRKLKLQLEEE--RQKCSRNDGT------- 283
AQ+ S E + V +LR+ A + + ++ + + + E E R + N+
Sbjct: 1558 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1617
Query: 284 -VGDLAGL-QNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEG------ 335
V L Q ++ Q E +R+A R+ + + + E LE+ EG
Sbjct: 1618 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL 1677
Query: 336 ----QVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKA 391
+++R + E E+ L+ E +LQRE A K +E+E L K++A
Sbjct: 1678 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE-------AELAKVRA 1730
Query: 392 NRTALLAQQ 400
LLA +
Sbjct: 1731 EMEVLLASK 1739
Score = 45.4 bits (106), Expect = 9e-05
Identities = 86/434 (19%), Positives = 159/434 (36%), Gaps = 47/434 (10%)
Query: 5 ASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKELDEKS 64
AS ++T +R E+ RE R A ++A AR+ RELER Q + +E
Sbjct: 1551 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1610
Query: 65 D-KQYAENYTRPSSRNSASA---TTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSEVE 120
+ AE + S A A + RRG + ++ + + EL + E
Sbjct: 1611 RLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAE 1670
Query: 121 EKYKKAMVSNAQLDN---EKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKH 177
++ + + +L E Q L++ + + + A ++ +E EL + +
Sbjct: 1671 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA 1730
Query: 178 MCSVL-------QHKMEELKEGLRQR--------DELIEKHGLV--IIPDGTPNGDVSHE 220
VL + + E +QR EL E+ + + + ++ E
Sbjct: 1731 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1790
Query: 221 PVAGAITVVSQEAAQVLESAGEG-----PLDVRLRKLAGEKEELLSQIRKLKLQLEEERQ 275
A + A+ L + GE ++ L++ E E L Q +
Sbjct: 1791 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1850
Query: 276 KCSRNDGTVGD-LAGLQNGSDLQF----------IEMQRDANRQISEYKFKLSKAEQDIT 324
+ +++ + + LA L+ SD + + +R +I K KA
Sbjct: 1851 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1910
Query: 325 TLEQSISRLEG---QVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKI----EEMEM 377
LE + R+ LR K AE + +L AE+ + +RE + K EE
Sbjct: 1911 ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 1970
Query: 378 TNSHLAKRLEKMKA 391
+ +E++KA
Sbjct: 1971 QRKAALEEVERLKA 1984
Score = 38.5 bits (88), Expect = 0.011
Identities = 84/398 (21%), Positives = 155/398 (38%), Gaps = 49/398 (12%)
Query: 29 REAEARLAAKRAARAEARDIRMRELE---RQQKELDEKSDK--QYAENYTRPSSRNSASA 83
RE A+L + A D+R RELE RQ + E +D + ++ R R
Sbjct: 1146 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR---RQEQIQ 1202
Query: 84 TTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSEVEE--KYKKAMVSNAQLDNEKNNLI 141
PL+ + + R L L E+ +VEE ++ K + NA D E +
Sbjct: 1203 AMPLADSQAVR-----EQLRQEQALLEEIERHGEKVEECQRFAKQYI-NAIKDYELQLVT 1256
Query: 142 YQVD-------TLKDVIEEQEEQMAEFYRENEEKSKEL-----ERQKHMCSVLQHKMEEL 189
Y+ K ++ E + + Y + EL + K + L+ EE
Sbjct: 1257 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1316
Query: 190 KEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRL 249
+ +QR E E+ L + E A A +EA ++ + E +V
Sbjct: 1317 RLAEQQRAE--ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE---EVVR 1371
Query: 250 RKLAG-----EKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRD 304
R+ A +K + ++++L+ E E Q +R + + L+ +++ + +Q +
Sbjct: 1372 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR-QAEAAERSRLRIEEEIRVVRLQLE 1430
Query: 305 ANR--------QISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAE-KVEDELK 355
A ++ + + +AE ++ RL QV AE ++ +K
Sbjct: 1431 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1490
Query: 356 AEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANR 393
AE + RE + AL +EE+ + +RL + + R
Sbjct: 1491 AE-AEAAREKQRALQALEELRLQAEEAERRLRQAEVER 1527
Score = 32.3 bits (72), Expect = 0.78
Identities = 61/299 (20%), Positives = 122/299 (40%), Gaps = 30/299 (10%)
Query: 108 SLSELRESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEE 167
+L EL + + +++ +A D ++ L + + + + E+ E R E
Sbjct: 1089 TLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER 1148
Query: 168 KSKELERQKHMCS---VLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAG 224
++ LER + + + V Q ++E+L LR E + G + + P+A
Sbjct: 1149 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD 1208
Query: 225 AITV---VSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRND 281
+ V + QE A + E G ++ A ++ ++ I+ +LQL + +
Sbjct: 1209 SQAVREQLRQEQALLEEIERHGEKVEECQRFA---KQYINAIKDYELQLVTYKAQLE--- 1262
Query: 282 GTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYK 341
S + ++Q + I EY L ++TTL + + LR
Sbjct: 1263 ---------PVASPAKKPKVQSGSESVIQEY-VDLRTHYSELTTLTSQYIKFISETLR-- 1310
Query: 342 TAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ 400
E E++ ++ +AE+R+ E+ AL+K + ++ +H K +A R A QQ
Sbjct: 1311 -RMEEEERLAEQQRAEERERLAEVEAALEK--QRQLAEAHAQ---AKAQAEREAKELQQ 1363
Score = 30.8 bits (68), Expect = 2.3
Identities = 34/179 (18%), Positives = 83/179 (46%), Gaps = 19/179 (10%)
Query: 113 RESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKEL 172
++ +++ ++ ++ Q++ E+ L+ ++ + E EE + R +E+ ++L
Sbjct: 2489 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV----RRKQEELQQL 2544
Query: 173 ERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQE 232
E+Q+ L + E + LR++ +L+E+ + + +V+ VA T+ +
Sbjct: 2545 EQQRRQQEEL---LAEENQRLREQLQLLEEQHRAAL---AHSEEVTASQVAATKTLPNGR 2598
Query: 233 AA---QVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLA 288
A E+ E D RK++ ++ +++ + EE Q+ ++ TV +LA
Sbjct: 2599 DALDGPAAEAEPEHSFDGLRRKVSAQR------LQEAGILSAEELQRLAQGHTTVDELA 2651
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 57.8 bits (138), Expect = 2e-08
Identities = 90/436 (20%), Positives = 181/436 (41%), Gaps = 59/436 (13%)
Query: 13 VKDRFSAEDEALSNIAREAE-ARLAAKRAARAEARDIRMRELERQ--QKELDEKSDKQYA 69
V D+ E EA A EAE AR+ A+R A R + E +Q +++ ++ Q A
Sbjct: 2212 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2271
Query: 70 ENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSEVEEKYKKAMVS 129
R + A+ + R+ + + + ++VE++ +
Sbjct: 2272 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ 2331
Query: 130 NAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEEL 189
+ D++KN L ++ LK E Q ++ EE+ + Q S L+ ++E
Sbjct: 2332 LEETDHQKNLLDEELQRLKAEATEAARQRSQV----EEELFSVRVQMEELSKLKARIEAE 2387
Query: 190 KEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRL 249
L RD+ + + + V+ E A ++V +QEAA++ + A E R
Sbjct: 2388 NRALILRDK--DNTQRFLQEEAEKMKQVAEE--AARLSVAAQEAARLRQLAEEDLAQQRA 2443
Query: 250 --RKLAGEKEELLSQIRKLKLQ-----------------LEEERQKCSRN--DGTVGDLA 288
K+ EK + + + +LK + L+E++++ ++ + T G
Sbjct: 2444 LAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQR 2503
Query: 289 GLQNGSDLQFIEMQRDANR---QISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAE 345
L+ Q +EM +A R +++E ++AE+D + + ++ R + A +
Sbjct: 2504 TLEAERQRQ-LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ 2562
Query: 346 ------------------NAEKVED---ELKAEKRKLQRELRTALDKIEEMEMTNSHLAK 384
+AE++ + EL+ EK KLQ+E + K EEM+ +
Sbjct: 2563 EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE--Q 2620
Query: 385 RLEKMKANRTALLAQQ 400
L++ +A + + L+++
Sbjct: 2621 LLQETQALQQSFLSEK 2636
Score = 57.4 bits (137), Expect = 2e-08
Identities = 86/430 (20%), Positives = 178/430 (41%), Gaps = 41/430 (9%)
Query: 5 ASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELE-----RQQKE 59
A R+ +R + + S R+AE LA++ A AEA + R L+ R Q E
Sbjct: 1624 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1683
Query: 60 LDEKSDKQYAENYTR-------PSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSEL 112
E+ +Q R + R++ + + + + + SL + ++++L
Sbjct: 1684 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1743
Query: 113 RESLSEVEEKYKKAMVSNAQLDNE-------KNNLIYQVDTLKDVIEEQEEQMAEFYREN 165
RE ++ +A + + + E N + ++V +++ AE ++
Sbjct: 1744 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1803
Query: 166 EEKSKELE----------RQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNG 215
EE +E RQ+ + K +L EG Q+ L + L+ + T G
Sbjct: 1804 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ-RLAAEQELIRLRAETEQG 1862
Query: 216 DVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQ----LE 271
+ + + + + +EAA + E L+ L K+ E E LL+ + + + E
Sbjct: 1863 EQQRQLLEEELARLQREAAAATQKRQE--LEAELAKVRAEMEVLLASKARAEEESRSTSE 1920
Query: 272 EERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSIS 331
+ +Q+ G +LA + + L+ + + RQ++E +AE + L + ++
Sbjct: 1921 KSKQRLEAEAGRFRELA--EEAARLRALAEEAKRQRQLAEEDAARQRAEAE-RVLAEKLA 1977
Query: 332 RLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTN-SHLAKRLEKMK 390
+ G+ R KT AE A K ++ R+L + ++EE + + + +RL +++
Sbjct: 1978 AI-GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 2036
Query: 391 ANRTALLAQQ 400
+ L +Q
Sbjct: 2037 KASDSELERQ 2046
Score = 55.5 bits (132), Expect = 9e-08
Identities = 94/418 (22%), Positives = 171/418 (40%), Gaps = 40/418 (9%)
Query: 14 KDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMR-ELERQQKELDEKSDKQYAENY 72
+ R AE++A A EAE LA K AA EA ++ E+ ++KE + + ++ AE+
Sbjct: 1952 RQRQLAEEDAARQRA-EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDE 2010
Query: 73 TRPSSRNSASATTPLSGNSSR----RGSGDTSS------LIDPDTSLSELRESLSEVEEK 122
R A + R R + D+ + D ++ E + ++
Sbjct: 2011 AFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKAS 2070
Query: 123 YKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVL 182
++KA A+L+ E + + D + +E+ E R+ + ++E R++ +
Sbjct: 2071 FEKAAAGKAELELELGRIRSNAE---DTLRSKEQAELEAARQRQLAAEEERRRREAEERV 2127
Query: 183 QHKMEELKEGLRQRDELIEK-HGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAG 241
Q + +E RQR +E+ L + E + ++QEAAQ A
Sbjct: 2128 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2187
Query: 242 EGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDL----- 296
E +++ E ++ L Q + + QL E + +R + A +Q +
Sbjct: 2188 EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE-AARRAAEEAEEARVQAEREAAQSRR 2246
Query: 297 ---------QFIEMQRDANRQISEYKFKLSK-AEQDITTLEQSISRLEGQVLRYKTAA-- 344
Q E Q A Q KL K AEQ+ Q+ E LR K AA
Sbjct: 2247 QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA----EQAALRQKQAADA 2302
Query: 345 --ENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ 400
E +K ++ +K ++++EL T ++EE + + L + L+++KA T Q+
Sbjct: 2303 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2360
Score = 54.3 bits (129), Expect = 2e-07
Identities = 91/429 (21%), Positives = 172/429 (40%), Gaps = 46/429 (10%)
Query: 8 RKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELE----RQQKELDEK 63
++R ++R + + AL + AEA AK A EA++++ R E R++ +D +
Sbjct: 1490 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQ 1549
Query: 64 SDKQYAENYTRPSSRNS-----ASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSE 118
K+ + + ++S A A + SR + ++ +E + +E
Sbjct: 1550 QQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAE 1609
Query: 119 VEEKYKKAMVSNA-----QLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELE 173
E + +A A Q E L QV + E ++A + E ++E +
Sbjct: 1610 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1669
Query: 174 RQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEA 233
R L+ + EE + LRQ + +E+ V + T E + +++
Sbjct: 1670 RALQALEELRLQAEEAERRLRQAE--VERARQVQVALETAQRSAEAE-LQSKRASFAEKT 1726
Query: 234 AQVLESAGEGPLDV-RLRKLAGEKEELLSQIRKLKLQLEEE--RQKCSRNDGT------- 283
AQ+ S E + V +LR+ A + + ++ + + + E E R + N+
Sbjct: 1727 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1786
Query: 284 -VGDLAGL-QNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEG------ 335
V L Q ++ Q E +R+A R+ + + + E LE+ EG
Sbjct: 1787 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL 1846
Query: 336 ----QVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKA 391
+++R + E E+ L+ E +LQRE A K +E+E L K++A
Sbjct: 1847 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE-------AELAKVRA 1899
Query: 392 NRTALLAQQ 400
LLA +
Sbjct: 1900 EMEVLLASK 1908
Score = 45.4 bits (106), Expect = 9e-05
Identities = 86/434 (19%), Positives = 159/434 (36%), Gaps = 47/434 (10%)
Query: 5 ASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKELDEKS 64
AS ++T +R E+ RE R A ++A AR+ RELER Q + +E
Sbjct: 1720 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1779
Query: 65 D-KQYAENYTRPSSRNSASA---TTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSEVE 120
+ AE + S A A + RRG + ++ + + EL + E
Sbjct: 1780 RLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAE 1839
Query: 121 EKYKKAMVSNAQLDN---EKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKH 177
++ + + +L E Q L++ + + + A ++ +E EL + +
Sbjct: 1840 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA 1899
Query: 178 MCSVL-------QHKMEELKEGLRQR--------DELIEKHGLV--IIPDGTPNGDVSHE 220
VL + + E +QR EL E+ + + + ++ E
Sbjct: 1900 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1959
Query: 221 PVAGAITVVSQEAAQVLESAGEG-----PLDVRLRKLAGEKEELLSQIRKLKLQLEEERQ 275
A + A+ L + GE ++ L++ E E L Q +
Sbjct: 1960 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 2019
Query: 276 KCSRNDGTVGD-LAGLQNGSDLQF----------IEMQRDANRQISEYKFKLSKAEQDIT 324
+ +++ + + LA L+ SD + + +R +I K KA
Sbjct: 2020 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 2079
Query: 325 TLEQSISRLEG---QVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKI----EEMEM 377
LE + R+ LR K AE + +L AE+ + +RE + K EE
Sbjct: 2080 ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 2139
Query: 378 TNSHLAKRLEKMKA 391
+ +E++KA
Sbjct: 2140 QRKAALEEVERLKA 2153
Score = 38.5 bits (88), Expect = 0.011
Identities = 84/398 (21%), Positives = 155/398 (38%), Gaps = 49/398 (12%)
Query: 29 REAEARLAAKRAARAEARDIRMRELE---RQQKELDEKSDK--QYAENYTRPSSRNSASA 83
RE A+L + A D+R RELE RQ + E +D + ++ R R
Sbjct: 1315 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR---RQEQIQ 1371
Query: 84 TTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSEVEE--KYKKAMVSNAQLDNEKNNLI 141
PL+ + + R L L E+ +VEE ++ K + NA D E +
Sbjct: 1372 AMPLADSQAVR-----EQLRQEQALLEEIERHGEKVEECQRFAKQYI-NAIKDYELQLVT 1425
Query: 142 YQVD-------TLKDVIEEQEEQMAEFYRENEEKSKEL-----ERQKHMCSVLQHKMEEL 189
Y+ K ++ E + + Y + EL + K + L+ EE
Sbjct: 1426 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1485
Query: 190 KEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRL 249
+ +QR E E+ L + E A A +EA ++ + E +V
Sbjct: 1486 RLAEQQRAE--ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE---EVVR 1540
Query: 250 RKLAG-----EKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRD 304
R+ A +K + ++++L+ E E Q +R + + L+ +++ + +Q +
Sbjct: 1541 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR-QAEAAERSRLRIEEEIRVVRLQLE 1599
Query: 305 ANR--------QISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAE-KVEDELK 355
A ++ + + +AE ++ RL QV AE ++ +K
Sbjct: 1600 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1659
Query: 356 AEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANR 393
AE + RE + AL +EE+ + +RL + + R
Sbjct: 1660 AE-AEAAREKQRALQALEELRLQAEEAERRLRQAEVER 1696
Score = 32.3 bits (72), Expect = 0.78
Identities = 61/299 (20%), Positives = 122/299 (40%), Gaps = 30/299 (10%)
Query: 108 SLSELRESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEE 167
+L EL + + +++ +A D ++ L + + + + E+ E R E
Sbjct: 1258 TLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER 1317
Query: 168 KSKELERQKHMCS---VLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAG 224
++ LER + + + V Q ++E+L LR E + G + + P+A
Sbjct: 1318 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD 1377
Query: 225 AITV---VSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRND 281
+ V + QE A + E G ++ A ++ ++ I+ +LQL + +
Sbjct: 1378 SQAVREQLRQEQALLEEIERHGEKVEECQRFA---KQYINAIKDYELQLVTYKAQLE--- 1431
Query: 282 GTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYK 341
S + ++Q + I EY L ++TTL + + LR
Sbjct: 1432 ---------PVASPAKKPKVQSGSESVIQEY-VDLRTHYSELTTLTSQYIKFISETLR-- 1479
Query: 342 TAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ 400
E E++ ++ +AE+R+ E+ AL+K + ++ +H K +A R A QQ
Sbjct: 1480 -RMEEEERLAEQQRAEERERLAEVEAALEK--QRQLAEAHAQ---AKAQAEREAKELQQ 1532
Score = 30.8 bits (68), Expect = 2.3
Identities = 34/179 (18%), Positives = 83/179 (46%), Gaps = 19/179 (10%)
Query: 113 RESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKEL 172
++ +++ ++ ++ Q++ E+ L+ ++ + E EE + R +E+ ++L
Sbjct: 2658 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV----RRKQEELQQL 2713
Query: 173 ERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQE 232
E+Q+ L + E + LR++ +L+E+ + + +V+ VA T+ +
Sbjct: 2714 EQQRRQQEEL---LAEENQRLREQLQLLEEQHRAAL---AHSEEVTASQVAATKTLPNGR 2767
Query: 233 AA---QVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLA 288
A E+ E D RK++ ++ +++ + EE Q+ ++ TV +LA
Sbjct: 2768 DALDGPAAEAEPEHSFDGLRRKVSAQR------LQEAGILSAEELQRLAQGHTTVDELA 2820
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 57.8 bits (138), Expect = 2e-08
Identities = 90/436 (20%), Positives = 181/436 (41%), Gaps = 59/436 (13%)
Query: 13 VKDRFSAEDEALSNIAREAE-ARLAAKRAARAEARDIRMRELERQ--QKELDEKSDKQYA 69
V D+ E EA A EAE AR+ A+R A R + E +Q +++ ++ Q A
Sbjct: 2053 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAA 2112
Query: 70 ENYTRPSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSEVEEKYKKAMVS 129
R + A+ + R+ + + + ++VE++ +
Sbjct: 2113 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ 2172
Query: 130 NAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVLQHKMEEL 189
+ D++KN L ++ LK E Q ++ EE+ + Q S L+ ++E
Sbjct: 2173 LEETDHQKNLLDEELQRLKAEATEAARQRSQV----EEELFSVRVQMEELSKLKARIEAE 2228
Query: 190 KEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRL 249
L RD+ + + + V+ E A ++V +QEAA++ + A E R
Sbjct: 2229 NRALILRDK--DNTQRFLQEEAEKMKQVAEE--AARLSVAAQEAARLRQLAEEDLAQQRA 2284
Query: 250 --RKLAGEKEELLSQIRKLKLQ-----------------LEEERQKCSRN--DGTVGDLA 288
K+ EK + + + +LK + L+E++++ ++ + T G
Sbjct: 2285 LAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQR 2344
Query: 289 GLQNGSDLQFIEMQRDANR---QISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAE 345
L+ Q +EM +A R +++E ++AE+D + + ++ R + A +
Sbjct: 2345 TLEAERQRQ-LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ 2403
Query: 346 ------------------NAEKVED---ELKAEKRKLQRELRTALDKIEEMEMTNSHLAK 384
+AE++ + EL+ EK KLQ+E + K EEM+ +
Sbjct: 2404 EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE--Q 2461
Query: 385 RLEKMKANRTALLAQQ 400
L++ +A + + L+++
Sbjct: 2462 LLQETQALQQSFLSEK 2477
Score = 57.4 bits (137), Expect = 2e-08
Identities = 86/430 (20%), Positives = 178/430 (41%), Gaps = 41/430 (9%)
Query: 5 ASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELE-----RQQKE 59
A R+ +R + + S R+AE LA++ A AEA + R L+ R Q E
Sbjct: 1465 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1524
Query: 60 LDEKSDKQYAENYTR-------PSSRNSASATTPLSGNSSRRGSGDTSSLIDPDTSLSEL 112
E+ +Q R + R++ + + + + + SL + ++++L
Sbjct: 1525 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1584
Query: 113 RESLSEVEEKYKKAMVSNAQLDNE-------KNNLIYQVDTLKDVIEEQEEQMAEFYREN 165
RE ++ +A + + + E N + ++V +++ AE ++
Sbjct: 1585 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1644
Query: 166 EEKSKELE----------RQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNG 215
EE +E RQ+ + K +L EG Q+ L + L+ + T G
Sbjct: 1645 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ-RLAAEQELIRLRAETEQG 1703
Query: 216 DVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQ----LE 271
+ + + + + +EAA + E L+ L K+ E E LL+ + + + E
Sbjct: 1704 EQQRQLLEEELARLQREAAAATQKRQE--LEAELAKVRAEMEVLLASKARAEEESRSTSE 1761
Query: 272 EERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSIS 331
+ +Q+ G +LA + + L+ + + RQ++E +AE + L + ++
Sbjct: 1762 KSKQRLEAEAGRFRELA--EEAARLRALAEEAKRQRQLAEEDAARQRAEAE-RVLAEKLA 1818
Query: 332 RLEGQVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTN-SHLAKRLEKMK 390
+ G+ R KT AE A K ++ R+L + ++EE + + + +RL +++
Sbjct: 1819 AI-GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1877
Query: 391 ANRTALLAQQ 400
+ L +Q
Sbjct: 1878 KASDSELERQ 1887
Score = 55.5 bits (132), Expect = 9e-08
Identities = 94/418 (22%), Positives = 171/418 (40%), Gaps = 40/418 (9%)
Query: 14 KDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMR-ELERQQKELDEKSDKQYAENY 72
+ R AE++A A EAE LA K AA EA ++ E+ ++KE + + ++ AE+
Sbjct: 1793 RQRQLAEEDAARQRA-EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDE 1851
Query: 73 TRPSSRNSASATTPLSGNSSR----RGSGDTSS------LIDPDTSLSELRESLSEVEEK 122
R A + R R + D+ + D ++ E + ++
Sbjct: 1852 AFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKAS 1911
Query: 123 YKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVL 182
++KA A+L+ E + + D + +E+ E R+ + ++E R++ +
Sbjct: 1912 FEKAAAGKAELELELGRIRSNAE---DTLRSKEQAELEAARQRQLAAEEERRRREAEERV 1968
Query: 183 QHKMEELKEGLRQRDELIEK-HGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAG 241
Q + +E RQR +E+ L + E + ++QEAAQ A
Sbjct: 1969 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE 2028
Query: 242 EGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDL----- 296
E +++ E ++ L Q + + QL E + +R + A +Q +
Sbjct: 2029 EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE-AARRAAEEAEEARVQAEREAAQSRR 2087
Query: 297 ---------QFIEMQRDANRQISEYKFKLSK-AEQDITTLEQSISRLEGQVLRYKTAA-- 344
Q E Q A Q KL K AEQ+ Q+ E LR K AA
Sbjct: 2088 QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA----EQAALRQKQAADA 2143
Query: 345 --ENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ 400
E +K ++ +K ++++EL T ++EE + + L + L+++KA T Q+
Sbjct: 2144 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2201
Score = 54.3 bits (129), Expect = 2e-07
Identities = 91/429 (21%), Positives = 172/429 (40%), Gaps = 46/429 (10%)
Query: 8 RKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELE----RQQKELDEK 63
++R ++R + + AL + AEA AK A EA++++ R E R++ +D +
Sbjct: 1331 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQ 1390
Query: 64 SDKQYAENYTRPSSRNS-----ASATTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSE 118
K+ + + ++S A A + SR + ++ +E + +E
Sbjct: 1391 QQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAE 1450
Query: 119 VEEKYKKAMVSNA-----QLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELE 173
E + +A A Q E L QV + E ++A + E ++E +
Sbjct: 1451 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1510
Query: 174 RQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEA 233
R L+ + EE + LRQ + +E+ V + T E + +++
Sbjct: 1511 RALQALEELRLQAEEAERRLRQAE--VERARQVQVALETAQRSAEAE-LQSKRASFAEKT 1567
Query: 234 AQVLESAGEGPLDV-RLRKLAGEKEELLSQIRKLKLQLEEE--RQKCSRNDGT------- 283
AQ+ S E + V +LR+ A + + ++ + + + E E R + N+
Sbjct: 1568 AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1627
Query: 284 -VGDLAGL-QNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEG------ 335
V L Q ++ Q E +R+A R+ + + + E LE+ EG
Sbjct: 1628 EVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL 1687
Query: 336 ----QVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKA 391
+++R + E E+ L+ E +LQRE A K +E+E L K++A
Sbjct: 1688 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE-------AELAKVRA 1740
Query: 392 NRTALLAQQ 400
LLA +
Sbjct: 1741 EMEVLLASK 1749
Score = 45.4 bits (106), Expect = 9e-05
Identities = 86/434 (19%), Positives = 159/434 (36%), Gaps = 47/434 (10%)
Query: 5 ASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKELDEKS 64
AS ++T +R E+ RE R A ++A AR+ RELER Q + +E
Sbjct: 1561 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1620
Query: 65 D-KQYAENYTRPSSRNSASA---TTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSEVE 120
+ AE + S A A + RRG + ++ + + EL + E
Sbjct: 1621 RLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAE 1680
Query: 121 EKYKKAMVSNAQLDN---EKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKH 177
++ + + +L E Q L++ + + + A ++ +E EL + +
Sbjct: 1681 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA 1740
Query: 178 MCSVL-------QHKMEELKEGLRQR--------DELIEKHGLV--IIPDGTPNGDVSHE 220
VL + + E +QR EL E+ + + + ++ E
Sbjct: 1741 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1800
Query: 221 PVAGAITVVSQEAAQVLESAGEG-----PLDVRLRKLAGEKEELLSQIRKLKLQLEEERQ 275
A + A+ L + GE ++ L++ E E L Q +
Sbjct: 1801 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1860
Query: 276 KCSRNDGTVGD-LAGLQNGSDLQF----------IEMQRDANRQISEYKFKLSKAEQDIT 324
+ +++ + + LA L+ SD + + +R +I K KA
Sbjct: 1861 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1920
Query: 325 TLEQSISRLEG---QVLRYKTAAENAEKVEDELKAEKRKLQRELRTALDKI----EEMEM 377
LE + R+ LR K AE + +L AE+ + +RE + K EE
Sbjct: 1921 ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 1980
Query: 378 TNSHLAKRLEKMKA 391
+ +E++KA
Sbjct: 1981 QRKAALEEVERLKA 1994
Score = 38.5 bits (88), Expect = 0.011
Identities = 84/398 (21%), Positives = 155/398 (38%), Gaps = 49/398 (12%)
Query: 29 REAEARLAAKRAARAEARDIRMRELE---RQQKELDEKSDK--QYAENYTRPSSRNSASA 83
RE A+L + A D+R RELE RQ + E +D + ++ R R
Sbjct: 1156 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR---RQEQIQ 1212
Query: 84 TTPLSGNSSRRGSGDTSSLIDPDTSLSELRESLSEVEE--KYKKAMVSNAQLDNEKNNLI 141
PL+ + + R L L E+ +VEE ++ K + NA D E +
Sbjct: 1213 AMPLADSQAVR-----EQLRQEQALLEEIERHGEKVEECQRFAKQYI-NAIKDYELQLVT 1266
Query: 142 YQVD-------TLKDVIEEQEEQMAEFYRENEEKSKEL-----ERQKHMCSVLQHKMEEL 189
Y+ K ++ E + + Y + EL + K + L+ EE
Sbjct: 1267 YKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE 1326
Query: 190 KEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQEAAQVLESAGEGPLDVRL 249
+ +QR E E+ L + E A A +EA ++ + E +V
Sbjct: 1327 RLAEQQRAE--ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE---EVVR 1381
Query: 250 RKLAG-----EKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFIEMQRD 304
R+ A +K + ++++L+ E E Q +R + + L+ +++ + +Q +
Sbjct: 1382 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR-QAEAAERSRLRIEEEIRVVRLQLE 1440
Query: 305 ANR--------QISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAE-KVEDELK 355
A ++ + + +AE ++ RL QV AE ++ +K
Sbjct: 1441 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1500
Query: 356 AEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANR 393
AE + RE + AL +EE+ + +RL + + R
Sbjct: 1501 AE-AEAAREKQRALQALEELRLQAEEAERRLRQAEVER 1537
Score = 32.3 bits (72), Expect = 0.78
Identities = 61/299 (20%), Positives = 122/299 (40%), Gaps = 30/299 (10%)
Query: 108 SLSELRESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEE 167
+L EL + + +++ +A D ++ L + + + + E+ E R E
Sbjct: 1099 TLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER 1158
Query: 168 KSKELERQKHMCS---VLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAG 224
++ LER + + + V Q ++E+L LR E + G + + P+A
Sbjct: 1159 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD 1218
Query: 225 AITV---VSQEAAQVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRND 281
+ V + QE A + E G ++ A ++ ++ I+ +LQL + +
Sbjct: 1219 SQAVREQLRQEQALLEEIERHGEKVEECQRFA---KQYINAIKDYELQLVTYKAQLE--- 1272
Query: 282 GTVGDLAGLQNGSDLQFIEMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYK 341
S + ++Q + I EY L ++TTL + + LR
Sbjct: 1273 ---------PVASPAKKPKVQSGSESVIQEY-VDLRTHYSELTTLTSQYIKFISETLR-- 1320
Query: 342 TAAENAEKVEDELKAEKRKLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ 400
E E++ ++ +AE+R+ E+ AL+K + ++ +H K +A R A QQ
Sbjct: 1321 -RMEEEERLAEQQRAEERERLAEVEAALEK--QRQLAEAHAQ---AKAQAEREAKELQQ 1373
Score = 30.8 bits (68), Expect = 2.3
Identities = 34/179 (18%), Positives = 83/179 (46%), Gaps = 19/179 (10%)
Query: 113 RESLSEVEEKYKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKEL 172
++ +++ ++ ++ Q++ E+ L+ ++ + E EE + R +E+ ++L
Sbjct: 2499 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV----RRKQEELQQL 2554
Query: 173 ERQKHMCSVLQHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHEPVAGAITVVSQE 232
E+Q+ L + E + LR++ +L+E+ + + +V+ VA T+ +
Sbjct: 2555 EQQRRQQEEL---LAEENQRLREQLQLLEEQHRAAL---AHSEEVTASQVAATKTLPNGR 2608
Query: 233 AA---QVLESAGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLA 288
A E+ E D RK++ ++ +++ + EE Q+ ++ TV +LA
Sbjct: 2609 DALDGPAAEAEPEHSFDGLRRKVSAQR------LQEAGILSAEELQRLAQGHTTVDELA 2661
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.307 0.124 0.318
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,456,748
Number of Sequences: 37866
Number of extensions: 617971
Number of successful extensions: 11098
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 309
Number of HSP's successfully gapped in prelim test: 893
Number of HSP's that attempted gapping in prelim test: 5356
Number of HSP's gapped (non-prelim): 4228
length of query: 400
length of database: 18,247,518
effective HSP length: 104
effective length of query: 296
effective length of database: 14,309,454
effective search space: 4235598384
effective search space used: 4235598384
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.