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Search of human proteins with 88501740
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|88501740 TRIO and F-actin binding protein isoform 1 [Homo
sapiens]
(652 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|88501740 TRIO and F-actin binding protein isoform 1 [Homo sap... 1304 0.0
gi|88501738 TRIO and F-actin binding protein isoform 6 [Homo sap... 1174 0.0
gi|88501741 TRIO and F-actin binding protein isoform 2 [Homo sap... 806 0.0
gi|50980301 myosin phosphatase-Rho interacting protein isoform 2... 475 e-134
gi|50980307 myosin phosphatase-Rho interacting protein isoform 1... 475 e-134
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 74 4e-13
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 74 6e-13
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 74 6e-13
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 74 6e-13
gi|148746195 trichohyalin [Homo sapiens] 68 2e-11
gi|115648142 centrosomal protein 164kDa [Homo sapiens] 68 2e-11
gi|88196790 coiled-coil domain containing 88 [Homo sapiens] 67 7e-11
gi|71061468 centromere protein E [Homo sapiens] 66 1e-10
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 65 2e-10
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 64 6e-10
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 64 6e-10
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 64 6e-10
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 64 6e-10
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 64 6e-10
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 64 6e-10
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 64 6e-10
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 64 6e-10
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 63 7e-10
gi|145312241 differentially expressed in FDCP 6 homolog [Homo sa... 63 1e-09
gi|219803769 trichoplein [Homo sapiens] 63 1e-09
gi|14150056 trichoplein [Homo sapiens] 63 1e-09
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 62 2e-09
gi|194294525 intersectin 2 isoform 2 [Homo sapiens] 62 2e-09
gi|48762942 huntingtin interacting protein-1-related [Homo sapiens] 61 3e-09
gi|239750456 PREDICTED: similar to KIAA0655 protein [Homo sapiens] 61 3e-09
>gi|88501740 TRIO and F-actin binding protein isoform 1 [Homo
sapiens]
Length = 652
Score = 1304 bits (3375), Expect = 0.0
Identities = 652/652 (100%), Positives = 652/652 (100%)
Query: 1 MGGWKGPGQRRGKEGPEARRRAAERGGGGGGGGVPAPRSPAREPRPRSCLLLPPPWGAAM 60
MGGWKGPGQRRGKEGPEARRRAAERGGGGGGGGVPAPRSPAREPRPRSCLLLPPPWGAAM
Sbjct: 1 MGGWKGPGQRRGKEGPEARRRAAERGGGGGGGGVPAPRSPAREPRPRSCLLLPPPWGAAM 60
Query: 61 TPDLLNFKKGWMSILDEPGEPPSPSLTTTSTSQWKKHWFVLTDSSLKYYRDSTAEEADEL 120
TPDLLNFKKGWMSILDEPGEPPSPSLTTTSTSQWKKHWFVLTDSSLKYYRDSTAEEADEL
Sbjct: 61 TPDLLNFKKGWMSILDEPGEPPSPSLTTTSTSQWKKHWFVLTDSSLKYYRDSTAEEADEL 120
Query: 121 DGEIDLRSCTDVTEYAVQRNYGFQIHTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPD 180
DGEIDLRSCTDVTEYAVQRNYGFQIHTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPD
Sbjct: 121 DGEIDLRSCTDVTEYAVQRNYGFQIHTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPD 180
Query: 181 VTKLSDSNKENALHSYSTQKGPLKAGEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQ 240
VTKLSDSNKENALHSYSTQKGPLKAGEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQ
Sbjct: 181 VTKLSDSNKENALHSYSTQKGPLKAGEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQ 240
Query: 241 ASPQRARTPARTPDRLAKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAP 300
ASPQRARTPARTPDRLAKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAP
Sbjct: 241 ASPQRARTPARTPDRLAKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAP 300
Query: 301 LTEDQQNRLSEEIEKKWQELEKLPLRENKRVPLTALLNQSRGERRGPPSDGHEALEKEVQ 360
LTEDQQNRLSEEIEKKWQELEKLPLRENKRVPLTALLNQSRGERRGPPSDGHEALEKEVQ
Sbjct: 301 LTEDQQNRLSEEIEKKWQELEKLPLRENKRVPLTALLNQSRGERRGPPSDGHEALEKEVQ 360
Query: 361 ALRAQLEAWRLQGEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQQVMEELQRHH 420
ALRAQLEAWRLQGEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQQVMEELQRHH
Sbjct: 361 ALRAQLEAWRLQGEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQQVMEELQRHH 420
Query: 421 ERELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQQGPDGLRKQHQS 480
ERELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQQGPDGLRKQHQS
Sbjct: 421 ERELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQQGPDGLRKQHQS 480
Query: 481 DVEALKRELQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQQEGQELLRHNQELHGRLSE 540
DVEALKRELQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQQEGQELLRHNQELHGRLSE
Sbjct: 481 DVEALKRELQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQQEGQELLRHNQELHGRLSE 540
Query: 541 EIDQLRGFIASQGMGNGCGRSNERSSCELEVLLRVKENELQYLKKEVQCLRDELQMMQKD 600
EIDQLRGFIASQGMGNGCGRSNERSSCELEVLLRVKENELQYLKKEVQCLRDELQMMQKD
Sbjct: 541 EIDQLRGFIASQGMGNGCGRSNERSSCELEVLLRVKENELQYLKKEVQCLRDELQMMQKD 600
Query: 601 KRFTSGKYQDVYVELSHIKTRSEREIEQLKEHLRLAMAALQEKESMRNSLAE 652
KRFTSGKYQDVYVELSHIKTRSEREIEQLKEHLRLAMAALQEKESMRNSLAE
Sbjct: 601 KRFTSGKYQDVYVELSHIKTRSEREIEQLKEHLRLAMAALQEKESMRNSLAE 652
>gi|88501738 TRIO and F-actin binding protein isoform 6 [Homo sapiens]
Length = 2365
Score = 1174 bits (3038), Expect = 0.0
Identities = 604/642 (94%), Positives = 608/642 (94%), Gaps = 2/642 (0%)
Query: 13 KEGPEARRRAAERGGGGGGGG--VPAPRSPAREPRPRSCLLLPPPWGAAMTPDLLNFKKG 70
K+ A +R AE G G V + R P P + LL PDLLNFKKG
Sbjct: 1724 KQADSADKRPAEGKAGSPLKGRLVTSWRMPGDRPTLFNPFLLSLGVLRWRRPDLLNFKKG 1783
Query: 71 WMSILDEPGEPPSPSLTTTSTSQWKKHWFVLTDSSLKYYRDSTAEEADELDGEIDLRSCT 130
WMSILDEPGEPPSPSLTTTSTSQWKKHWFVLTDSSLKYYRDSTAEEADELDGEIDLRSCT
Sbjct: 1784 WMSILDEPGEPPSPSLTTTSTSQWKKHWFVLTDSSLKYYRDSTAEEADELDGEIDLRSCT 1843
Query: 131 DVTEYAVQRNYGFQIHTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPDVTKLSDSNKE 190
DVTEYAVQRNYGFQIHTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPDVTKLSDSNKE
Sbjct: 1844 DVTEYAVQRNYGFQIHTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPDVTKLSDSNKE 1903
Query: 191 NALHSYSTQKGPLKAGEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPA 250
NALHSYSTQKGPLKAGEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPA
Sbjct: 1904 NALHSYSTQKGPLKAGEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPA 1963
Query: 251 RTPDRLAKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAPLTEDQQNRLS 310
RTPDRLAKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAPLTEDQQNRLS
Sbjct: 1964 RTPDRLAKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAPLTEDQQNRLS 2023
Query: 311 EEIEKKWQELEKLPLRENKRVPLTALLNQSRGERRGPPSDGHEALEKEVQALRAQLEAWR 370
EEIEKKWQELEKLPLRENKRVPLTALLNQSRGERRGPPSDGHEALEKEVQALRAQLEAWR
Sbjct: 2024 EEIEKKWQELEKLPLRENKRVPLTALLNQSRGERRGPPSDGHEALEKEVQALRAQLEAWR 2083
Query: 371 LQGEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQQVMEELQRHHERELQRLQQE 430
LQGEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQQVMEELQRHHERELQRLQQE
Sbjct: 2084 LQGEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQQVMEELQRHHERELQRLQQE 2143
Query: 431 KEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQQGPDGLRKQHQSDVEALKRELQ 490
KEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQQGPDGLRKQHQSDVEALKRELQ
Sbjct: 2144 KEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQQGPDGLRKQHQSDVEALKRELQ 2203
Query: 491 VLSEQYSQKCLEIGALMRQAEEREHTLRRCQQEGQELLRHNQELHGRLSEEIDQLRGFIA 550
VLSEQYSQKCLEIGALMRQAEEREHTLRRCQQEGQELLRHNQELHGRLSEEIDQLRGFIA
Sbjct: 2204 VLSEQYSQKCLEIGALMRQAEEREHTLRRCQQEGQELLRHNQELHGRLSEEIDQLRGFIA 2263
Query: 551 SQGMGNGCGRSNERSSCELEVLLRVKENELQYLKKEVQCLRDELQMMQKDKRFTSGKYQD 610
SQGMGNGCGRSNERSSCELEVLLRVKENELQYLKKEVQCLRDELQMMQKDKRFTSGKYQD
Sbjct: 2264 SQGMGNGCGRSNERSSCELEVLLRVKENELQYLKKEVQCLRDELQMMQKDKRFTSGKYQD 2323
Query: 611 VYVELSHIKTRSEREIEQLKEHLRLAMAALQEKESMRNSLAE 652
VYVELSHIKTRSEREIEQLKEHLRLAMAALQEKESMRNSLAE
Sbjct: 2324 VYVELSHIKTRSEREIEQLKEHLRLAMAALQEKESMRNSLAE 2365
Score = 30.8 bits (68), Expect = 4.1
Identities = 41/149 (27%), Positives = 52/149 (34%), Gaps = 44/149 (29%)
Query: 240 QASPQRARTPARTPDR-LAKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEGPRR--- 295
Q SP RT ARTP+R L Q LE A + W E P +GP R
Sbjct: 1390 QGSPLPPRTSARTPERELRTQRPLESGQAGPRQPLGVW-----QSQEEPPGSQGPHRHLE 1444
Query: 296 --------GLG--------------APLTEDQQNRLSEEIEKKWQELE--------KLPL 325
GLG A E S E ++ W + E +LP
Sbjct: 1445 RSWSSQEGGLGPGGWWGCGEPSLGAAKAPEGAWGGTSREYKESWGQPEAWEEKPTHELPR 1504
Query: 326 RENKRVPLTALLNQSRGERRGPPSDGHEA 354
KR PLT S E G P++ ++
Sbjct: 1505 ELGKRSPLT-----SPPENWGGPAESSQS 1528
Score = 30.0 bits (66), Expect = 7.0
Identities = 46/207 (22%), Positives = 70/207 (33%), Gaps = 15/207 (7%)
Query: 189 KENALHSYSTQKGPLKAGEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRART 248
+EN S + Q P + RA +R PR + QR L TQ R
Sbjct: 765 QENLRTSCTRQDNPRTSSPNRA-----TRDNPRTSCAQRDNLRASSPIRATQQDNPRTCI 819
Query: 249 PARTPDRLAKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAPLTEDQQNR 308
P + Q++ + + + R D + P T+ + R
Sbjct: 820 QQNIPRSSSTQQDNPKTSCTKRDNLRPTCTQRDRTQSFSFQRDNPGTSSSQCCTQKENLR 879
Query: 309 LSEEIEK-KWQE-LEKLPLRENKRVPLTALL---NQSRGERRGPPSDGHEALEKEVQALR 363
S +W P R NK +P + QS G R PS K+ +
Sbjct: 880 PSSPHRSTQWNNPRNSSPHRTNKDIPWASFPLRPTQSDGPRTSSPSRS-----KQSEVPW 934
Query: 364 AQLEAWRLQGEAPQSALRSQEDGHIPP 390
A + QG+ PQ++ S+ H PP
Sbjct: 935 ASIALRPTQGDRPQTSSPSRPAQHDPP 961
>gi|88501741 TRIO and F-actin binding protein isoform 2 [Homo
sapiens]
Length = 431
Score = 806 bits (2082), Expect = 0.0
Identities = 395/395 (100%), Positives = 395/395 (100%)
Query: 1 MGGWKGPGQRRGKEGPEARRRAAERGGGGGGGGVPAPRSPAREPRPRSCLLLPPPWGAAM 60
MGGWKGPGQRRGKEGPEARRRAAERGGGGGGGGVPAPRSPAREPRPRSCLLLPPPWGAAM
Sbjct: 1 MGGWKGPGQRRGKEGPEARRRAAERGGGGGGGGVPAPRSPAREPRPRSCLLLPPPWGAAM 60
Query: 61 TPDLLNFKKGWMSILDEPGEPPSPSLTTTSTSQWKKHWFVLTDSSLKYYRDSTAEEADEL 120
TPDLLNFKKGWMSILDEPGEPPSPSLTTTSTSQWKKHWFVLTDSSLKYYRDSTAEEADEL
Sbjct: 61 TPDLLNFKKGWMSILDEPGEPPSPSLTTTSTSQWKKHWFVLTDSSLKYYRDSTAEEADEL 120
Query: 121 DGEIDLRSCTDVTEYAVQRNYGFQIHTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPD 180
DGEIDLRSCTDVTEYAVQRNYGFQIHTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPD
Sbjct: 121 DGEIDLRSCTDVTEYAVQRNYGFQIHTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPD 180
Query: 181 VTKLSDSNKENALHSYSTQKGPLKAGEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQ 240
VTKLSDSNKENALHSYSTQKGPLKAGEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQ
Sbjct: 181 VTKLSDSNKENALHSYSTQKGPLKAGEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQ 240
Query: 241 ASPQRARTPARTPDRLAKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAP 300
ASPQRARTPARTPDRLAKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAP
Sbjct: 241 ASPQRARTPARTPDRLAKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAP 300
Query: 301 LTEDQQNRLSEEIEKKWQELEKLPLRENKRVPLTALLNQSRGERRGPPSDGHEALEKEVQ 360
LTEDQQNRLSEEIEKKWQELEKLPLRENKRVPLTALLNQSRGERRGPPSDGHEALEKEVQ
Sbjct: 301 LTEDQQNRLSEEIEKKWQELEKLPLRENKRVPLTALLNQSRGERRGPPSDGHEALEKEVQ 360
Query: 361 ALRAQLEAWRLQGEAPQSALRSQEDGHIPPGYISQ 395
ALRAQLEAWRLQGEAPQSALRSQEDGHIPPGYISQ
Sbjct: 361 ALRAQLEAWRLQGEAPQSALRSQEDGHIPPGYISQ 395
>gi|50980301 myosin phosphatase-Rho interacting protein isoform 2
[Homo sapiens]
Length = 1025
Score = 475 bits (1223), Expect = e-134
Identities = 289/668 (43%), Positives = 396/668 (59%), Gaps = 45/668 (6%)
Query: 6 GPGQRRGKEGPEARRRAAERGGGGGGGGVPAPRSPAR----EPRPRSCLLLPPPWGAAMT 61
GP + +RA R PAP A P R+ L ++T
Sbjct: 324 GPSPSSDTRQGRSEKRAFPRKRDFTNEAPPAPLPDASASPLSPHRRAKSLDRRSTEPSVT 383
Query: 62 PDLLNFKKGWMSILDEPGEPPSPSLTTTSTSQWKKHWFVLTDSSLKYYRDSTAEEADELD 121
PDLLNFKKGW++ E G QWKKHWFVL D SL+YYRDS AEEA +LD
Sbjct: 384 PDLLNFKKGWLTKQYEDG-------------QWKKHWFVLADQSLRYYRDSVAEEAADLD 430
Query: 122 GEIDLRSCTDVTEYAVQRNYGFQIHTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPDV 181
GEIDL +C DVTEY VQRNYGFQIHTK+ +TLSAMTSGIRRNWI+ + K V PT+APDV
Sbjct: 431 GEIDLSACYDVTEYPVQRNYGFQIHTKEGEFTLSAMTSGIRRNWIQTIMKHVHPTTAPDV 490
Query: 182 TKLSDSNKENALHSYSTQKGPLKAGEQRAG----SEVISRGGPRKADGQRQALDYVELSP 237
T K + S+ T P + E G + SR R+ +G+ + D+ E P
Sbjct: 491 TSSLPEEKNKSSCSFETCPRPTEKQEAELGEPDPEQKRSRARERRREGRSKTFDWAEFRP 550
Query: 238 LTQASPQR---ARTPARTPDRL---AKQEELERDLAQRSEERRKWF---EATDS-RTPEV 287
+ QA Q PA T + L A+ ELER+ A+R EERRK F +ATD T +
Sbjct: 551 IQQALAQERVGGVGPADTHEPLRPEAEPGELERERARRREERRKRFGMLDATDGPGTEDA 610
Query: 288 PAGEGPRRGLGAPLTEDQQNRLSEEIEKKWQELEKLPLRENKRVPLTAL-LNQSRGERRG 346
R G P+++ + + + EIE++W ++E PLRE K+VP+ + L+ G R
Sbjct: 611 ALRMEVDRSPGLPMSDLKTHNVHVEIEQRWHQVETTPLREEKQVPIAPVHLSSEDGGDRL 670
Query: 347 PPSDGHEALEKEVQALRAQ----LEAWRLQGEAPQSALRSQEDGHIPPGYISQEACERSL 402
+ LEKE++ + + LE RL + + AL ++ GY+ Q CER
Sbjct: 671 STHELTSLLEKELEQSQKEASDLLEQNRLLQDQLRVALGREQSAR--EGYVLQATCERGF 728
Query: 403 AEMESSHQQVMEELQRHHERELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELS 462
A ME +HQ+ +E+LQR H+REL++L++EK+ LLAEETAAT SAIEAMK A++EE+ REL
Sbjct: 729 AAMEETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATISAIEAMKNAHREEMERELE 788
Query: 463 KTR-----SLQQGPDGLRKQHQSDVEALKRELQVLSEQYSQKCLEIGALMRQAEEREHTL 517
K++ S+ + LR+Q+ ++++++REL+VLSEQYSQKCLE L + E L
Sbjct: 789 KSQRSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLAQALEAERQAL 848
Query: 518 RRCQQEGQELLRHNQELHGRLSEEIDQLRGFIASQGMGNGCGR--SNERSSCELEVLLRV 575
R+CQ+E QEL HNQEL+ RL+ EI +LR + G G G + + + ELEVLLRV
Sbjct: 849 RQCQRENQELNAHNQELNNRLAAEITRLRTLLTGDGGGEATGSPLAQGKDAYELEVLLRV 908
Query: 576 KENELQYLKKEVQCLRDELQMMQKDKRFTSGKYQDVYVELSHIKTRSEREIEQLKEHLRL 635
KE+E+QYLK+E+ L+DELQ +DK++ S KY+D+Y ELS K +++ +I +LKE L+
Sbjct: 909 KESEIQYLKQEISSLKDELQTALRDKKYASDKYKDIYTELSIAKAKADCDISRLKEQLKA 968
Query: 636 AMAALQEK 643
A AL EK
Sbjct: 969 ATEALGEK 976
>gi|50980307 myosin phosphatase-Rho interacting protein isoform 1
[Homo sapiens]
Length = 1038
Score = 475 bits (1223), Expect = e-134
Identities = 289/668 (43%), Positives = 396/668 (59%), Gaps = 45/668 (6%)
Query: 6 GPGQRRGKEGPEARRRAAERGGGGGGGGVPAPRSPAR----EPRPRSCLLLPPPWGAAMT 61
GP + +RA R PAP A P R+ L ++T
Sbjct: 324 GPSPSSDTRQGRSEKRAFPRKRDFTNEAPPAPLPDASASPLSPHRRAKSLDRRSTEPSVT 383
Query: 62 PDLLNFKKGWMSILDEPGEPPSPSLTTTSTSQWKKHWFVLTDSSLKYYRDSTAEEADELD 121
PDLLNFKKGW++ E G QWKKHWFVL D SL+YYRDS AEEA +LD
Sbjct: 384 PDLLNFKKGWLTKQYEDG-------------QWKKHWFVLADQSLRYYRDSVAEEAADLD 430
Query: 122 GEIDLRSCTDVTEYAVQRNYGFQIHTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPDV 181
GEIDL +C DVTEY VQRNYGFQIHTK+ +TLSAMTSGIRRNWI+ + K V PT+APDV
Sbjct: 431 GEIDLSACYDVTEYPVQRNYGFQIHTKEGEFTLSAMTSGIRRNWIQTIMKHVHPTTAPDV 490
Query: 182 TKLSDSNKENALHSYSTQKGPLKAGEQRAG----SEVISRGGPRKADGQRQALDYVELSP 237
T K + S+ T P + E G + SR R+ +G+ + D+ E P
Sbjct: 491 TSSLPEEKNKSSCSFETCPRPTEKQEAELGEPDPEQKRSRARERRREGRSKTFDWAEFRP 550
Query: 238 LTQASPQR---ARTPARTPDRL---AKQEELERDLAQRSEERRKWF---EATDS-RTPEV 287
+ QA Q PA T + L A+ ELER+ A+R EERRK F +ATD T +
Sbjct: 551 IQQALAQERVGGVGPADTHEPLRPEAEPGELERERARRREERRKRFGMLDATDGPGTEDA 610
Query: 288 PAGEGPRRGLGAPLTEDQQNRLSEEIEKKWQELEKLPLRENKRVPLTAL-LNQSRGERRG 346
R G P+++ + + + EIE++W ++E PLRE K+VP+ + L+ G R
Sbjct: 611 ALRMEVDRSPGLPMSDLKTHNVHVEIEQRWHQVETTPLREEKQVPIAPVHLSSEDGGDRL 670
Query: 347 PPSDGHEALEKEVQALRAQ----LEAWRLQGEAPQSALRSQEDGHIPPGYISQEACERSL 402
+ LEKE++ + + LE RL + + AL ++ GY+ Q CER
Sbjct: 671 STHELTSLLEKELEQSQKEASDLLEQNRLLQDQLRVALGREQSAR--EGYVLQATCERGF 728
Query: 403 AEMESSHQQVMEELQRHHERELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELS 462
A ME +HQ+ +E+LQR H+REL++L++EK+ LLAEETAAT SAIEAMK A++EE+ REL
Sbjct: 729 AAMEETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATISAIEAMKNAHREEMERELE 788
Query: 463 KTR-----SLQQGPDGLRKQHQSDVEALKRELQVLSEQYSQKCLEIGALMRQAEEREHTL 517
K++ S+ + LR+Q+ ++++++REL+VLSEQYSQKCLE L + E L
Sbjct: 789 KSQRSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLAQALEAERQAL 848
Query: 518 RRCQQEGQELLRHNQELHGRLSEEIDQLRGFIASQGMGNGCGR--SNERSSCELEVLLRV 575
R+CQ+E QEL HNQEL+ RL+ EI +LR + G G G + + + ELEVLLRV
Sbjct: 849 RQCQRENQELNAHNQELNNRLAAEITRLRTLLTGDGGGEATGSPLAQGKDAYELEVLLRV 908
Query: 576 KENELQYLKKEVQCLRDELQMMQKDKRFTSGKYQDVYVELSHIKTRSEREIEQLKEHLRL 635
KE+E+QYLK+E+ L+DELQ +DK++ S KY+D+Y ELS K +++ +I +LKE L+
Sbjct: 909 KESEIQYLKQEISSLKDELQTALRDKKYASDKYKDIYTELSIAKAKADCDISRLKEQLKA 968
Query: 636 AMAALQEK 643
A AL EK
Sbjct: 969 ATEALGEK 976
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 73.9 bits (180), Expect = 4e-13
Identities = 112/471 (23%), Positives = 193/471 (40%), Gaps = 81/471 (17%)
Query: 204 KAGEQRAGSEVI---SRGGPRKADGQRQALDYVELSPLTQASPQRARTPARTPDRLAKQE 260
++G Q +GSE S G R GQR SP ++SP R R+P R P
Sbjct: 465 ESGVQLSGSERTADASNGSLRGLSGQRTP------SPPRRSSPGRGRSPRRGPSPACSDS 518
Query: 261 E--------LERDLAQRSEERRKWFEATD---SRTPEVPAGEGPRRGLGAPLTE-----D 304
L + Q + R ++ + D + ++ E RR L L D
Sbjct: 519 STLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTD 578
Query: 305 QQNRLSEEIEKKWQELE---KLPLRENKRVPLTALLNQSRGERRGPPSDGHEALEKEVQA 361
+ E+ +++ Q L +L RE + + + Q + E + +A ++E++
Sbjct: 579 GAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRR 638
Query: 362 LRAQLEAWRLQGEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQQVMEELQRHHE 421
R +LE Q +A Q R + + E R L ++E + +EL E
Sbjct: 639 QRDRLE--EEQEDAVQDGARVRRE---------LERSHRQLEQLEGKRSVLAKELVEVRE 687
Query: 422 RELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQQGPDGLRKQHQSD 481
L R +++ L AE+ A EA+ KA + ELS T+ LR + S
Sbjct: 688 A-LSRATLQRDMLQAEK----AEVAEALTKAEAGRVELELSMTK--------LRAEEASL 734
Query: 482 VEALKRELQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQQEGQELLRHNQELHGRLSEE 541
++L + L L+E +Q L++ L+ Q EE + L+ Q++ ++ +E RL E
Sbjct: 735 QDSLSK-LSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEEL 793
Query: 542 IDQLRGFIASQGMGNGCGRSNERSSCELEVLLRVKENELQYLKKEVQCLRDELQMMQKDK 601
+L +A QG LE LRV E + L++++ LR E +Q+
Sbjct: 794 --RLEQEVARQG---------------LEGSLRVAEQAQEALEQQLPTLRHERSQLQEQ- 835
Query: 602 RFTSGKYQDVYVELSHIKTRSEREIEQLKEHLRLAMAALQEKESMRNSLAE 652
+LS + E+E+EQ + + + AL+ + +LA+
Sbjct: 836 ----------LAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAK 876
Score = 65.5 bits (158), Expect = 2e-10
Identities = 118/460 (25%), Positives = 187/460 (40%), Gaps = 56/460 (12%)
Query: 218 GGPRKADGQRQALDYVELSPLTQASPQRARTPARTPDRLAKQEELERDLAQRSEERRKWF 277
G R A+ ++AL+ +L L Q A+ +L+ +E+ +L Q E ++
Sbjct: 806 GSLRVAEQAQEALEQ-QLPTLRHERSQLQEQLAQLSRQLSGREQ---ELEQARREAQRQV 861
Query: 278 EATDSRTPEVPAGEGPRRGLGAPLT--EDQQNRLSEEIEKKWQELEKLPLRENKRVPLTA 335
EA + E A GL L E + LSEE + E E L E +
Sbjct: 862 EALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEAL---EGSLFEVQR 918
Query: 336 LLNQSRGERRGPPSDGHEALEKEVQALRAQLEAWRLQGEAPQSALRSQEDGHIPPGYISQ 395
L Q R E LE E QAL E L GE + LR Q + +
Sbjct: 919 QLAQLEARR--------EQLEAEGQALLLAKET--LTGEL--AGLRQQIIATQEKASLDK 966
Query: 396 EACERSLAEMESSHQQVMEELQRHHERELQRLQQEKE--WL-LAEETAATASAIE----- 447
E + L + E Q + E + HE +LQRLQ+EKE W L E A S ++
Sbjct: 967 ELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEE 1026
Query: 448 --AMKKAYQEELSRELSKTRSLQQGPDGL-----RKQH-----QSDVEALKRELQVLSEQ 495
A +A +EELS E++ + Q+ +GL KQ +S+ AL +L
Sbjct: 1027 LLARLEAEKEELSEEIAALQ--QERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHS 1084
Query: 496 YSQKCLEIGALMRQAEEREH----TLRRCQQEGQELLRHNQELHGRLSEEIDQLRGFIAS 551
+ LE+ R A+ R+ T+ E ++L +E ++E+ +L+
Sbjct: 1085 LATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARD 1144
Query: 552 QG-MGNGCGRSNERSSCELEVLLRVKENELQYLKKEVQCLRDELQMMQKDKRFTSGKYQD 610
G + C R E EL LR+ E+ L++E+ + +L+ Q+ + +
Sbjct: 1145 LGKQRDSCLREAE----ELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREV----QRQ 1196
Query: 611 VYVELSHIKTRSEREIEQLKEHLRLAMAALQEKESMRNSL 650
EL +E E L+ +A+++ ES R SL
Sbjct: 1197 EAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISL 1236
Score = 63.9 bits (154), Expect = 4e-10
Identities = 106/482 (21%), Positives = 201/482 (41%), Gaps = 45/482 (9%)
Query: 191 NALHSYSTQKGPLKAGEQRAGSEVIS--RGGPRKADGQRQALD--YVELSPLTQASPQRA 246
+ALH Q ++ G A +++ R ++ +R+AL+ L T + Q
Sbjct: 526 SALHKRQLQVQDMR-GRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAH 584
Query: 247 RTPARTPDRLAKQEEL----ERDLAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAPLT 302
R RL EL + +LA + ++ E ++ A + R L
Sbjct: 585 EDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLE 644
Query: 303 EDQQN------RLSEEIEKKWQELEKLPLRENKRVPLTALLNQSRG--ERRGPPSDGHEA 354
E+Q++ R+ E+E+ ++LE+L E KR L L + R R D +A
Sbjct: 645 EEQEDAVQDGARVRRELERSHRQLEQL---EGKRSVLAKELVEVREALSRATLQRDMLQA 701
Query: 355 LEKEVQALRAQLEAWRLQGEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQQVME 414
+ EV + EA R++ E + LR++E + + SL+++ + ++ + +
Sbjct: 702 EKAEVAEALTKAEAGRVELELSMTKLRAEE-----------ASLQDSLSKLSALNESLAQ 750
Query: 415 ELQRHHERELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQQGPDGL 474
+ + R + +L++EK L + A A A ++ QE L + +QG +G
Sbjct: 751 D-KLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREE--QERLEELRLEQEVARQGLEGS 807
Query: 475 RKQHQSDVEALKRELQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQQEGQE----LLRH 530
+ + EAL+++L L + SQ ++ L RQ RE L + ++E Q L R
Sbjct: 808 LRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERA 867
Query: 531 NQELHGRLSEEIDQLRGFIASQGMGNGCGRSNERSSCELEVL---LRVKENELQYLKKEV 587
+E E +A++ G R E E L L + +L L+
Sbjct: 868 AREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARR 927
Query: 588 QCLRDELQMMQKDKRFTSGKYQDVYVELSHIKTRSEREIEQLKEHL----RLAMAALQEK 643
+ L E Q + K +G+ + ++ + ++ + E + + L R A A+L+E+
Sbjct: 928 EQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQ 987
Query: 644 ES 645
+
Sbjct: 988 RA 989
Score = 53.9 bits (128), Expect = 5e-07
Identities = 103/459 (22%), Positives = 170/459 (37%), Gaps = 50/459 (10%)
Query: 206 GEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPARTPDRLAKQEELERD 265
GE S + G + G R A E + QA Q A+ ++L + E+D
Sbjct: 326 GELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQ-----AQLEEQLRDKVLREKD 380
Query: 266 LAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAPLTEDQQNRLSEEIEKKWQELEKLPL 325
LAQ ++ + + D G +R L +DQ N+ ++ +K + LE L L
Sbjct: 381 LAQ--QQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNK---DLTEKLEALESLRL 435
Query: 326 RENKRVPLT---ALLNQSRGERRGPPSDGHEALEKEVQALRAQLEAWRLQG----EAPQS 378
+E + L R + SD ++ A L+G P
Sbjct: 436 QEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSP 495
Query: 379 ALRSQEDGHIPPGYISQEACERSLAEMESSHQQVMEELQRHHERELQRLQQEKEWLLAEE 438
RS P AC S + + H + H+R+LQ + +++
Sbjct: 496 PRRSSPGRGRSPRRGPSPACSDS-STLALIHSAL-------HKRQLQVQDMRGRYEASQD 547
Query: 439 TAAT----ASAIEAMKKAYQEELSRELSKTRSLQQGPDGLRKQHQSDVEALKRELQVLSE 494
T S E+ ++A +E+L R KT Q + Q +V+ L+ ++LS
Sbjct: 548 LLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQA----HEDAQREVQRLRSANELLSR 603
Query: 495 QYSQKCLEIGALMRQAEEREHTLRRCQQEGQELLRHNQELHGRLSEEIDQLRGFIASQGM 554
+ S + +QAEE + Q +EL R L + +
Sbjct: 604 EKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQD---------- 653
Query: 555 GNGCGRSNERSSCELEVLLRVKENELQYLKKEVQCLRDELQMMQKDKRFTSGKYQDVYVE 614
G R ERS +LE L E + L KE+ +R+ L + + +V
Sbjct: 654 GARVRRELERSHRQLEQL----EGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEA 709
Query: 615 LSHIKT-RSEREIEQLKEHLRLAMAALQEKESMRNSLAE 652
L+ + R E E+ K LR A+LQ+ S ++L E
Sbjct: 710 LTKAEAGRVELELSMTK--LRAEEASLQDSLSKLSALNE 746
Score = 33.9 bits (76), Expect = 0.48
Identities = 45/186 (24%), Positives = 76/186 (40%), Gaps = 17/186 (9%)
Query: 378 SALRSQEDGHIPPGYISQEACERSLAEMESSHQQVMEELQRHHERELQRLQQEKEWLLAE 437
S L QE+ + +S+ E LA+ + ++ + ER Q L+ E L +
Sbjct: 75 SLLSLQEENQLLQQELSR--VEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQ 132
Query: 438 ETAATASAIEAMKKAYQEELSRELSKTRSLQQGPDGLRKQHQSDVEALKRELQVLSEQYS 497
E +++ QEE + S R LQ +G ++Q Q L + LQ QY
Sbjct: 133 EPRGLVRQSVELRRQLQEE---QASYRRKLQAYQEGQQRQAQ-----LVQRLQGKILQYK 184
Query: 498 QKCLEI-GALMRQAEEREHTLRRCQQEGQEL------LRHNQELHGRLSEEIDQLRGFIA 550
++C E+ L+ ++ E E R + Q+L L Q+ L++ LR +
Sbjct: 185 KRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLD 244
Query: 551 SQGMGN 556
G N
Sbjct: 245 QAGSAN 250
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 73.6 bits (179), Expect = 6e-13
Identities = 119/490 (24%), Positives = 197/490 (40%), Gaps = 72/490 (14%)
Query: 203 LKAGEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPARTPDRLAK-QEE 261
L+A +E+ S R+ QR+ ++L + + R A ++L + Q E
Sbjct: 1254 LEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAE 1313
Query: 262 LERDLAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAPLTEDQQNRLSEEIEKKWQELE 321
LE +E K T + E+ + E L E+ + +L+ + E E
Sbjct: 1314 LENVSGALNEAESK----TIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAE 1369
Query: 322 KLPLRENKRVPLTALLNQSRGERRGPPSDGHEALEKEVQALRAQLEAWRLQGEAPQSALR 381
LRE A ER G +E+Q +AQL WR + E AL
Sbjct: 1370 AAGLREQLEEEAAAR------ERAG----------RELQTAQAQLSEWRRRQEEEAGALE 1413
Query: 382 SQEDGHIPPGYISQEACERSLAE-------MESSHQQVMEEL---------QRHHERELQ 425
+ E+ EA + LAE +E +++ +EL QR L+
Sbjct: 1414 AGEEARRRAAR-EAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLE 1472
Query: 426 RLQQEKEWLLAEETAATASAIEAMKKAYQEELSRE---LSKTRSLQQGPDGLRKQHQSDV 482
+ Q++ + LLAEE AA A+E ++A E RE LS TR+L++ + R++ +
Sbjct: 1473 KKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEA-REELERQN 1531
Query: 483 EALKRELQVL---SEQYSQKCLEIGALMRQAEEREHTLRRCQQEGQELL----------- 528
AL+ EL+ L + + E+ R AE+ + LR E ++ L
Sbjct: 1532 RALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLE 1591
Query: 529 --------RHNQELHGRLSEEIDQLRGFIASQGMGNGCGRSNERSSCELEVLLRVK-ENE 579
+H ++L GR E ++ R +A Q R ER L V R K E E
Sbjct: 1592 VTVQALKTQHERDLQGR-DEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGE 1650
Query: 580 LQYLKKEVQCLRDELQMMQKDKRFTSGKYQDVYVELSHIKTRSE------REIEQLKEHL 633
L+ LK ++ + K R + ++++ E+ +T E RE E+ + L
Sbjct: 1651 LEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGL 1710
Query: 634 RLAMAALQEK 643
+ LQE+
Sbjct: 1711 EAEVLRLQEE 1720
Score = 58.5 bits (140), Expect = 2e-08
Identities = 97/408 (23%), Positives = 170/408 (41%), Gaps = 53/408 (12%)
Query: 255 RLAKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAPLTEDQQNRLSEEIE 314
R+ ++EE R Q E+++ + + A EG R+ L Q +++ E +
Sbjct: 955 RVGEEEECSR---QMQTEKKRLQQHIQELEAHLEAEEGARQKL-------QLEKVTTEAK 1004
Query: 315 KKWQELEKLPLRE-NKRVPLTALLNQSRGERRGPPSDGHEALEKEVQALRAQLEAWRLQG 373
K E + L L + N ++ L + R + E K + LR + EA
Sbjct: 1005 MKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADM 1064
Query: 374 EAPQSALRSQEDGHIPPGYISQEACERSL-AEMESSHQQVMEELQRHHERELQRLQQEKE 432
E LR +E G E +R L E +Q++E+ QR E Q ++E+E
Sbjct: 1065 E---DRLRKEEKGRQ-----ELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEE 1116
Query: 433 WLLA-----EETAATASAIEAMKKAYQ--EELSRELSKTRSLQQGPDGLRKQHQSDVEAL 485
A +E A A ++++++A E +L R + + R+ ++EAL
Sbjct: 1117 LQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEAL 1176
Query: 486 KRELQ-------VLSEQYSQKCLEIGALMRQAEEREHTLRRCQQEGQELLRHNQELHGRL 538
+ EL+ E S++ E+ L + EE QE ++ RH Q L G L
Sbjct: 1177 RGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQ--RHGQAL-GEL 1233
Query: 539 SEEIDQLRGFIASQGMGNGCGRSNERSSCELEVL-LRVKENELQYLKKEVQCLRDELQMM 597
+E+++Q R G G R + E EV LR + + LQ ++E + R L++
Sbjct: 1234 AEQLEQAR-------RGKGAWEKT-RLALEAEVSELRAELSSLQTARQEGEQRRRRLELQ 1285
Query: 598 QKDKRFTSGKYQDVYVELSHIKTRSEREIEQLKEHLRLAMAALQEKES 645
++ + +G + E + R++ E+E + AL E ES
Sbjct: 1286 LQEVQGRAGDGERARAEAAEKLQRAQAELENVS-------GALNEAES 1326
Score = 48.1 bits (113), Expect = 2e-05
Identities = 73/349 (20%), Positives = 142/349 (40%), Gaps = 45/349 (12%)
Query: 234 ELSPLTQASPQRARTPARTPDRLAKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEGP 293
E + + +A +R R A +R A+ L R L + E R + + E+ A
Sbjct: 1485 EKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSS 1544
Query: 294 RRGLGAPLTEDQQ-----NRLSEEIEKKWQELE-KLPLRENKR----VPLTALLNQSRGE 343
+ +G + E ++ + + ++ + ELE +L E+ + V + AL Q +
Sbjct: 1545 KDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERD 1604
Query: 344 RRGPPSDGHEALEKEVQALR-AQLEA--------------WRLQGEAPQSALRSQEDGHI 388
+G G E + + LR A++E +L+GE + + G
Sbjct: 1605 LQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQG 1664
Query: 389 PPGYISQ--------EACERSLAEMESSHQQVMEELQRHHER------ELQRLQQEKEWL 434
+ Q + R + E +S +++ + + +R E+ RLQ+E
Sbjct: 1665 KEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEE---- 1720
Query: 435 LAEETAATASAIEAMKKAYQEELSRELSKTRSLQQGP--DGLRKQHQSDVEALKRELQVL 492
LA A A + + E + LSK L++ +G Q + ++E + ++L
Sbjct: 1721 LAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELL 1780
Query: 493 SEQYSQKCLEIGALMRQAEEREHTLRRCQQEGQELLRHNQELHGRLSEE 541
+++Y + L++ +L + + + Q+L R QEL GRL EE
Sbjct: 1781 NDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEE 1829
Score = 41.6 bits (96), Expect = 0.002
Identities = 69/331 (20%), Positives = 126/331 (38%), Gaps = 42/331 (12%)
Query: 350 DGHEALEKEVQALRAQLEAWRLQGEAP-------QSALRSQEDGHIPPGYISQEACERS- 401
DG +A EK +QAL +R+ G++ + L + D + +S +A R
Sbjct: 767 DGKQACEKMIQALELDPNLYRV-GQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARGY 825
Query: 402 LAEMESSHQQVMEELQRHHERELQRLQQEKEWLLAEETAATASAIEAMKK-AYQEELSRE 460
LA +Q + R +R + + W ++ ++ + ++E
Sbjct: 826 LARRAFQKRQQQQSALRVMQRNCAAYLKLRHWQWWRLFTKVKPLLQVTRQDEVLQARAQE 885
Query: 461 LSKTRSLQQGPDGLRKQHQSDVEALKRELQVLSEQY---SQKCLE--------------- 502
L K + LQQ + Q V L+ E L+EQ ++ C E
Sbjct: 886 LQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQEL 945
Query: 503 ---IGALMRQAEEREHTLRRCQQEGQELLRHNQELHGRLSEEIDQLRGFIASQGMGNGCG 559
+ L + E E R+ Q E + L +H QEL L E + R + + +
Sbjct: 946 ELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAE-EGARQKLQLEKV----- 999
Query: 560 RSNERSSCELEVLLRVKENELQYLKKEVQCLRDELQMMQKDKRFTSGKYQDVYVELSHIK 619
+ E + E L + E++ L KE + L D L + + ++ L+ ++
Sbjct: 1000 -TTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQ----AAEEEEKVKSLNKLR 1054
Query: 620 TRSEREIEQLKEHLRLAMAALQEKESMRNSL 650
+ E I +++ LR QE E ++ L
Sbjct: 1055 LKYEATIADMEDRLRKEEKGRQELEKLKRRL 1085
Score = 37.7 bits (86), Expect = 0.034
Identities = 52/262 (19%), Positives = 119/262 (45%), Gaps = 36/262 (13%)
Query: 388 IPPGYIS-QEACERSLA--EMESSHQQVMEELQRHHERELQRLQQEKEWLLAEETAATAS 444
IP G++ ++ACE+ + E++ + +V + L +L++E++ + +
Sbjct: 761 IPKGFMDGKQACEKMIQALELDPNLYRVGQSKIFFRAGVLAQLEEERDLKVTD------- 813
Query: 445 AIEAMKKAYQEELSRELSKTRSLQQGPDGLRKQHQSDVEALKRE----LQVLSEQYSQKC 500
I + + A + L+R R+ Q+ R+Q QS + ++R L++ Q+ +
Sbjct: 814 IIVSFQAAARGYLAR-----RAFQK-----RQQQQSALRVMQRNCAAYLKLRHWQWWRLF 863
Query: 501 LEIGALMRQAEEREHTLRRCQQEGQELLRHNQELHGRLSEEIDQLRGFIASQGMGNGCGR 560
++ L++ + E R Q+ L+ QEL + + E+ +L+G +A + R
Sbjct: 864 TKVKPLLQVTRQDEVLQARAQE-----LQKVQELQQQSAREVGELQGRVAQ--LEEERAR 916
Query: 561 SNERSSCELEVLLRVKENELQYLKKEVQCLRDELQMMQKDKRFTSGKYQDVYVELSHIKT 620
E+ E E+ +E + + + EL+++ + G+ ++ ++ K
Sbjct: 917 LAEQLRAEAELCAEAEET-----RGRLAARKQELELVVSELEARVGEEEECSRQMQTEKK 971
Query: 621 RSEREIEQLKEHLRLAMAALQE 642
R ++ I++L+ HL A Q+
Sbjct: 972 RLQQHIQELEAHLEAEEGARQK 993
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 73.6 bits (179), Expect = 6e-13
Identities = 119/490 (24%), Positives = 197/490 (40%), Gaps = 72/490 (14%)
Query: 203 LKAGEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPARTPDRLAK-QEE 261
L+A +E+ S R+ QR+ ++L + + R A ++L + Q E
Sbjct: 1246 LEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAE 1305
Query: 262 LERDLAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAPLTEDQQNRLSEEIEKKWQELE 321
LE +E K T + E+ + E L E+ + +L+ + E E
Sbjct: 1306 LENVSGALNEAESK----TIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAE 1361
Query: 322 KLPLRENKRVPLTALLNQSRGERRGPPSDGHEALEKEVQALRAQLEAWRLQGEAPQSALR 381
LRE A ER G +E+Q +AQL WR + E AL
Sbjct: 1362 AAGLREQLEEEAAAR------ERAG----------RELQTAQAQLSEWRRRQEEEAGALE 1405
Query: 382 SQEDGHIPPGYISQEACERSLAE-------MESSHQQVMEEL---------QRHHERELQ 425
+ E+ EA + LAE +E +++ +EL QR L+
Sbjct: 1406 AGEEARRRAAR-EAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLE 1464
Query: 426 RLQQEKEWLLAEETAATASAIEAMKKAYQEELSRE---LSKTRSLQQGPDGLRKQHQSDV 482
+ Q++ + LLAEE AA A+E ++A E RE LS TR+L++ + R++ +
Sbjct: 1465 KKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEA-REELERQN 1523
Query: 483 EALKRELQVL---SEQYSQKCLEIGALMRQAEEREHTLRRCQQEGQELL----------- 528
AL+ EL+ L + + E+ R AE+ + LR E ++ L
Sbjct: 1524 RALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLE 1583
Query: 529 --------RHNQELHGRLSEEIDQLRGFIASQGMGNGCGRSNERSSCELEVLLRVK-ENE 579
+H ++L GR E ++ R +A Q R ER L V R K E E
Sbjct: 1584 VTVQALKTQHERDLQGR-DEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGE 1642
Query: 580 LQYLKKEVQCLRDELQMMQKDKRFTSGKYQDVYVELSHIKTRSE------REIEQLKEHL 633
L+ LK ++ + K R + ++++ E+ +T E RE E+ + L
Sbjct: 1643 LEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGL 1702
Query: 634 RLAMAALQEK 643
+ LQE+
Sbjct: 1703 EAEVLRLQEE 1712
Score = 58.5 bits (140), Expect = 2e-08
Identities = 97/408 (23%), Positives = 170/408 (41%), Gaps = 53/408 (12%)
Query: 255 RLAKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAPLTEDQQNRLSEEIE 314
R+ ++EE R Q E+++ + + A EG R+ L Q +++ E +
Sbjct: 947 RVGEEEECSR---QMQTEKKRLQQHIQELEAHLEAEEGARQKL-------QLEKVTTEAK 996
Query: 315 KKWQELEKLPLRE-NKRVPLTALLNQSRGERRGPPSDGHEALEKEVQALRAQLEAWRLQG 373
K E + L L + N ++ L + R + E K + LR + EA
Sbjct: 997 MKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADM 1056
Query: 374 EAPQSALRSQEDGHIPPGYISQEACERSL-AEMESSHQQVMEELQRHHERELQRLQQEKE 432
E LR +E G E +R L E +Q++E+ QR E Q ++E+E
Sbjct: 1057 E---DRLRKEEKGRQ-----ELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEE 1108
Query: 433 WLLA-----EETAATASAIEAMKKAYQ--EELSRELSKTRSLQQGPDGLRKQHQSDVEAL 485
A +E A A ++++++A E +L R + + R+ ++EAL
Sbjct: 1109 LQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEAL 1168
Query: 486 KRELQ-------VLSEQYSQKCLEIGALMRQAEEREHTLRRCQQEGQELLRHNQELHGRL 538
+ EL+ E S++ E+ L + EE QE ++ RH Q L G L
Sbjct: 1169 RGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQ--RHGQAL-GEL 1225
Query: 539 SEEIDQLRGFIASQGMGNGCGRSNERSSCELEVL-LRVKENELQYLKKEVQCLRDELQMM 597
+E+++Q R G G R + E EV LR + + LQ ++E + R L++
Sbjct: 1226 AEQLEQAR-------RGKGAWEKT-RLALEAEVSELRAELSSLQTARQEGEQRRRRLELQ 1277
Query: 598 QKDKRFTSGKYQDVYVELSHIKTRSEREIEQLKEHLRLAMAALQEKES 645
++ + +G + E + R++ E+E + AL E ES
Sbjct: 1278 LQEVQGRAGDGERARAEAAEKLQRAQAELENVS-------GALNEAES 1318
Score = 48.1 bits (113), Expect = 2e-05
Identities = 73/349 (20%), Positives = 142/349 (40%), Gaps = 45/349 (12%)
Query: 234 ELSPLTQASPQRARTPARTPDRLAKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEGP 293
E + + +A +R R A +R A+ L R L + E R + + E+ A
Sbjct: 1477 EKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSS 1536
Query: 294 RRGLGAPLTEDQQ-----NRLSEEIEKKWQELE-KLPLRENKR----VPLTALLNQSRGE 343
+ +G + E ++ + + ++ + ELE +L E+ + V + AL Q +
Sbjct: 1537 KDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERD 1596
Query: 344 RRGPPSDGHEALEKEVQALR-AQLEA--------------WRLQGEAPQSALRSQEDGHI 388
+G G E + + LR A++E +L+GE + + G
Sbjct: 1597 LQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQG 1656
Query: 389 PPGYISQ--------EACERSLAEMESSHQQVMEELQRHHER------ELQRLQQEKEWL 434
+ Q + R + E +S +++ + + +R E+ RLQ+E
Sbjct: 1657 KEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEE---- 1712
Query: 435 LAEETAATASAIEAMKKAYQEELSRELSKTRSLQQGP--DGLRKQHQSDVEALKRELQVL 492
LA A A + + E + LSK L++ +G Q + ++E + ++L
Sbjct: 1713 LAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELL 1772
Query: 493 SEQYSQKCLEIGALMRQAEEREHTLRRCQQEGQELLRHNQELHGRLSEE 541
+++Y + L++ +L + + + Q+L R QEL GRL EE
Sbjct: 1773 NDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEE 1821
Score = 41.6 bits (96), Expect = 0.002
Identities = 69/331 (20%), Positives = 126/331 (38%), Gaps = 42/331 (12%)
Query: 350 DGHEALEKEVQALRAQLEAWRLQGEAP-------QSALRSQEDGHIPPGYISQEACERS- 401
DG +A EK +QAL +R+ G++ + L + D + +S +A R
Sbjct: 759 DGKQACEKMIQALELDPNLYRV-GQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARGY 817
Query: 402 LAEMESSHQQVMEELQRHHERELQRLQQEKEWLLAEETAATASAIEAMKK-AYQEELSRE 460
LA +Q + R +R + + W ++ ++ + ++E
Sbjct: 818 LARRAFQKRQQQQSALRVMQRNCAAYLKLRHWQWWRLFTKVKPLLQVTRQDEVLQARAQE 877
Query: 461 LSKTRSLQQGPDGLRKQHQSDVEALKRELQVLSEQY---SQKCLE--------------- 502
L K + LQQ + Q V L+ E L+EQ ++ C E
Sbjct: 878 LQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQEL 937
Query: 503 ---IGALMRQAEEREHTLRRCQQEGQELLRHNQELHGRLSEEIDQLRGFIASQGMGNGCG 559
+ L + E E R+ Q E + L +H QEL L E + R + + +
Sbjct: 938 ELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAE-EGARQKLQLEKV----- 991
Query: 560 RSNERSSCELEVLLRVKENELQYLKKEVQCLRDELQMMQKDKRFTSGKYQDVYVELSHIK 619
+ E + E L + E++ L KE + L D L + + ++ L+ ++
Sbjct: 992 -TTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQ----AAEEEEKVKSLNKLR 1046
Query: 620 TRSEREIEQLKEHLRLAMAALQEKESMRNSL 650
+ E I +++ LR QE E ++ L
Sbjct: 1047 LKYEATIADMEDRLRKEEKGRQELEKLKRRL 1077
Score = 37.7 bits (86), Expect = 0.034
Identities = 52/262 (19%), Positives = 119/262 (45%), Gaps = 36/262 (13%)
Query: 388 IPPGYIS-QEACERSLA--EMESSHQQVMEELQRHHERELQRLQQEKEWLLAEETAATAS 444
IP G++ ++ACE+ + E++ + +V + L +L++E++ + +
Sbjct: 753 IPKGFMDGKQACEKMIQALELDPNLYRVGQSKIFFRAGVLAQLEEERDLKVTD------- 805
Query: 445 AIEAMKKAYQEELSRELSKTRSLQQGPDGLRKQHQSDVEALKRE----LQVLSEQYSQKC 500
I + + A + L+R R+ Q+ R+Q QS + ++R L++ Q+ +
Sbjct: 806 IIVSFQAAARGYLAR-----RAFQK-----RQQQQSALRVMQRNCAAYLKLRHWQWWRLF 855
Query: 501 LEIGALMRQAEEREHTLRRCQQEGQELLRHNQELHGRLSEEIDQLRGFIASQGMGNGCGR 560
++ L++ + E R Q+ L+ QEL + + E+ +L+G +A + R
Sbjct: 856 TKVKPLLQVTRQDEVLQARAQE-----LQKVQELQQQSAREVGELQGRVAQ--LEEERAR 908
Query: 561 SNERSSCELEVLLRVKENELQYLKKEVQCLRDELQMMQKDKRFTSGKYQDVYVELSHIKT 620
E+ E E+ +E + + + EL+++ + G+ ++ ++ K
Sbjct: 909 LAEQLRAEAELCAEAEET-----RGRLAARKQELELVVSELEARVGEEEECSRQMQTEKK 963
Query: 621 RSEREIEQLKEHLRLAMAALQE 642
R ++ I++L+ HL A Q+
Sbjct: 964 RLQQHIQELEAHLEAEEGARQK 985
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 73.6 bits (179), Expect = 6e-13
Identities = 119/490 (24%), Positives = 197/490 (40%), Gaps = 72/490 (14%)
Query: 203 LKAGEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPARTPDRLAK-QEE 261
L+A +E+ S R+ QR+ ++L + + R A ++L + Q E
Sbjct: 1287 LEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAE 1346
Query: 262 LERDLAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAPLTEDQQNRLSEEIEKKWQELE 321
LE +E K T + E+ + E L E+ + +L+ + E E
Sbjct: 1347 LENVSGALNEAESK----TIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAE 1402
Query: 322 KLPLRENKRVPLTALLNQSRGERRGPPSDGHEALEKEVQALRAQLEAWRLQGEAPQSALR 381
LRE A ER G +E+Q +AQL WR + E AL
Sbjct: 1403 AAGLREQLEEEAAAR------ERAG----------RELQTAQAQLSEWRRRQEEEAGALE 1446
Query: 382 SQEDGHIPPGYISQEACERSLAE-------MESSHQQVMEEL---------QRHHERELQ 425
+ E+ EA + LAE +E +++ +EL QR L+
Sbjct: 1447 AGEEARRRAAR-EAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLE 1505
Query: 426 RLQQEKEWLLAEETAATASAIEAMKKAYQEELSRE---LSKTRSLQQGPDGLRKQHQSDV 482
+ Q++ + LLAEE AA A+E ++A E RE LS TR+L++ + R++ +
Sbjct: 1506 KKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEA-REELERQN 1564
Query: 483 EALKRELQVL---SEQYSQKCLEIGALMRQAEEREHTLRRCQQEGQELL----------- 528
AL+ EL+ L + + E+ R AE+ + LR E ++ L
Sbjct: 1565 RALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLE 1624
Query: 529 --------RHNQELHGRLSEEIDQLRGFIASQGMGNGCGRSNERSSCELEVLLRVK-ENE 579
+H ++L GR E ++ R +A Q R ER L V R K E E
Sbjct: 1625 VTVQALKTQHERDLQGR-DEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGE 1683
Query: 580 LQYLKKEVQCLRDELQMMQKDKRFTSGKYQDVYVELSHIKTRSE------REIEQLKEHL 633
L+ LK ++ + K R + ++++ E+ +T E RE E+ + L
Sbjct: 1684 LEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGL 1743
Query: 634 RLAMAALQEK 643
+ LQE+
Sbjct: 1744 EAEVLRLQEE 1753
Score = 58.5 bits (140), Expect = 2e-08
Identities = 97/408 (23%), Positives = 170/408 (41%), Gaps = 53/408 (12%)
Query: 255 RLAKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAPLTEDQQNRLSEEIE 314
R+ ++EE R Q E+++ + + A EG R+ L Q +++ E +
Sbjct: 988 RVGEEEECSR---QMQTEKKRLQQHIQELEAHLEAEEGARQKL-------QLEKVTTEAK 1037
Query: 315 KKWQELEKLPLRE-NKRVPLTALLNQSRGERRGPPSDGHEALEKEVQALRAQLEAWRLQG 373
K E + L L + N ++ L + R + E K + LR + EA
Sbjct: 1038 MKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADM 1097
Query: 374 EAPQSALRSQEDGHIPPGYISQEACERSL-AEMESSHQQVMEELQRHHERELQRLQQEKE 432
E LR +E G E +R L E +Q++E+ QR E Q ++E+E
Sbjct: 1098 E---DRLRKEEKGRQ-----ELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEE 1149
Query: 433 WLLA-----EETAATASAIEAMKKAYQ--EELSRELSKTRSLQQGPDGLRKQHQSDVEAL 485
A +E A A ++++++A E +L R + + R+ ++EAL
Sbjct: 1150 LQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEAL 1209
Query: 486 KRELQ-------VLSEQYSQKCLEIGALMRQAEEREHTLRRCQQEGQELLRHNQELHGRL 538
+ EL+ E S++ E+ L + EE QE ++ RH Q L G L
Sbjct: 1210 RGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQ--RHGQAL-GEL 1266
Query: 539 SEEIDQLRGFIASQGMGNGCGRSNERSSCELEVL-LRVKENELQYLKKEVQCLRDELQMM 597
+E+++Q R G G R + E EV LR + + LQ ++E + R L++
Sbjct: 1267 AEQLEQAR-------RGKGAWEKT-RLALEAEVSELRAELSSLQTARQEGEQRRRRLELQ 1318
Query: 598 QKDKRFTSGKYQDVYVELSHIKTRSEREIEQLKEHLRLAMAALQEKES 645
++ + +G + E + R++ E+E + AL E ES
Sbjct: 1319 LQEVQGRAGDGERARAEAAEKLQRAQAELENVS-------GALNEAES 1359
Score = 48.1 bits (113), Expect = 2e-05
Identities = 73/349 (20%), Positives = 142/349 (40%), Gaps = 45/349 (12%)
Query: 234 ELSPLTQASPQRARTPARTPDRLAKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEGP 293
E + + +A +R R A +R A+ L R L + E R + + E+ A
Sbjct: 1518 EKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSS 1577
Query: 294 RRGLGAPLTEDQQ-----NRLSEEIEKKWQELE-KLPLRENKR----VPLTALLNQSRGE 343
+ +G + E ++ + + ++ + ELE +L E+ + V + AL Q +
Sbjct: 1578 KDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERD 1637
Query: 344 RRGPPSDGHEALEKEVQALR-AQLEA--------------WRLQGEAPQSALRSQEDGHI 388
+G G E + + LR A++E +L+GE + + G
Sbjct: 1638 LQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQG 1697
Query: 389 PPGYISQ--------EACERSLAEMESSHQQVMEELQRHHER------ELQRLQQEKEWL 434
+ Q + R + E +S +++ + + +R E+ RLQ+E
Sbjct: 1698 KEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEE---- 1753
Query: 435 LAEETAATASAIEAMKKAYQEELSRELSKTRSLQQGP--DGLRKQHQSDVEALKRELQVL 492
LA A A + + E + LSK L++ +G Q + ++E + ++L
Sbjct: 1754 LAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELL 1813
Query: 493 SEQYSQKCLEIGALMRQAEEREHTLRRCQQEGQELLRHNQELHGRLSEE 541
+++Y + L++ +L + + + Q+L R QEL GRL EE
Sbjct: 1814 NDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEE 1862
Score = 41.6 bits (96), Expect = 0.002
Identities = 69/331 (20%), Positives = 126/331 (38%), Gaps = 42/331 (12%)
Query: 350 DGHEALEKEVQALRAQLEAWRLQGEAP-------QSALRSQEDGHIPPGYISQEACERS- 401
DG +A EK +QAL +R+ G++ + L + D + +S +A R
Sbjct: 800 DGKQACEKMIQALELDPNLYRV-GQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARGY 858
Query: 402 LAEMESSHQQVMEELQRHHERELQRLQQEKEWLLAEETAATASAIEAMKK-AYQEELSRE 460
LA +Q + R +R + + W ++ ++ + ++E
Sbjct: 859 LARRAFQKRQQQQSALRVMQRNCAAYLKLRHWQWWRLFTKVKPLLQVTRQDEVLQARAQE 918
Query: 461 LSKTRSLQQGPDGLRKQHQSDVEALKRELQVLSEQY---SQKCLE--------------- 502
L K + LQQ + Q V L+ E L+EQ ++ C E
Sbjct: 919 LQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQEL 978
Query: 503 ---IGALMRQAEEREHTLRRCQQEGQELLRHNQELHGRLSEEIDQLRGFIASQGMGNGCG 559
+ L + E E R+ Q E + L +H QEL L E + R + + +
Sbjct: 979 ELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAE-EGARQKLQLEKV----- 1032
Query: 560 RSNERSSCELEVLLRVKENELQYLKKEVQCLRDELQMMQKDKRFTSGKYQDVYVELSHIK 619
+ E + E L + E++ L KE + L D L + + ++ L+ ++
Sbjct: 1033 -TTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQ----AAEEEEKVKSLNKLR 1087
Query: 620 TRSEREIEQLKEHLRLAMAALQEKESMRNSL 650
+ E I +++ LR QE E ++ L
Sbjct: 1088 LKYEATIADMEDRLRKEEKGRQELEKLKRRL 1118
Score = 37.7 bits (86), Expect = 0.034
Identities = 52/262 (19%), Positives = 119/262 (45%), Gaps = 36/262 (13%)
Query: 388 IPPGYIS-QEACERSLA--EMESSHQQVMEELQRHHERELQRLQQEKEWLLAEETAATAS 444
IP G++ ++ACE+ + E++ + +V + L +L++E++ + +
Sbjct: 794 IPKGFMDGKQACEKMIQALELDPNLYRVGQSKIFFRAGVLAQLEEERDLKVTD------- 846
Query: 445 AIEAMKKAYQEELSRELSKTRSLQQGPDGLRKQHQSDVEALKRE----LQVLSEQYSQKC 500
I + + A + L+R R+ Q+ R+Q QS + ++R L++ Q+ +
Sbjct: 847 IIVSFQAAARGYLAR-----RAFQK-----RQQQQSALRVMQRNCAAYLKLRHWQWWRLF 896
Query: 501 LEIGALMRQAEEREHTLRRCQQEGQELLRHNQELHGRLSEEIDQLRGFIASQGMGNGCGR 560
++ L++ + E R Q+ L+ QEL + + E+ +L+G +A + R
Sbjct: 897 TKVKPLLQVTRQDEVLQARAQE-----LQKVQELQQQSAREVGELQGRVAQ--LEEERAR 949
Query: 561 SNERSSCELEVLLRVKENELQYLKKEVQCLRDELQMMQKDKRFTSGKYQDVYVELSHIKT 620
E+ E E+ +E + + + EL+++ + G+ ++ ++ K
Sbjct: 950 LAEQLRAEAELCAEAEET-----RGRLAARKQELELVVSELEARVGEEEECSRQMQTEKK 1004
Query: 621 RSEREIEQLKEHLRLAMAALQE 642
R ++ I++L+ HL A Q+
Sbjct: 1005 RLQQHIQELEAHLEAEEGARQK 1026
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 68.2 bits (165), Expect = 2e-11
Identities = 103/427 (24%), Positives = 181/427 (42%), Gaps = 69/427 (16%)
Query: 259 QEELERDLAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAPLTEDQQNRLSEEIEKKWQ 318
Q+E E+ L + E+RR+ R + + ++ L E+ + R +E EKK++
Sbjct: 937 QQEEEQLLREEREKRRR-----QERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYR 991
Query: 319 ELEKLPLRENKRVPLTALLNQSRGERRGPPSDGH-----EALEKEVQALRAQLEAWRLQG 373
E E+L E + LL + R +RR + E ++E Q LR + E RLQ
Sbjct: 992 EEEELQQEEEQ------LLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQ- 1044
Query: 374 EAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQQVMEELQRHHE------------ 421
E + +E + +E R E+E +++ EELQ+ E
Sbjct: 1045 ERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKE-EELQQEEEQLLREEPEKRRR 1103
Query: 422 -------RELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQQGPDGL 474
RE + LQQE+E LL EE + +++ Y+EE + + + L++ P+
Sbjct: 1104 QERERQCREEEELQQEEEQLLREEREKRRR--QELERQYREEEEVQQEEEQLLREEPEKR 1161
Query: 475 RKQHQSDVEALKRELQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQQEGQELLRHNQEL 534
R+Q ++E RE + L ++ Q E RQ ER++ +E +EL R ++
Sbjct: 1162 RRQ---ELERQYREEEELQQEEEQLLREEQEKRRQERERQY------REEEELQRQKRKQ 1212
Query: 535 HGRLSEEIDQLRGFIASQGMGNGCGRSNERSSCELEVLLRVKENELQYLKKEVQCLRDEL 594
R ++ L+ + E + + +V + +ENE Q+ + E LRD
Sbjct: 1213 RYRDEDQRSDLKWQWEPE---------KENAVRDNKVYCKGRENE-QFRQLEDSQLRD-- 1260
Query: 595 QMMQKDKRFTSGKYQDVYVELS---------HIKTRSEREIEQLKEHLRLAMAALQEKES 645
+ Q+D + G+ Q+ E H + E E+ KE R + +EK+
Sbjct: 1261 RQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQL 1320
Query: 646 MRNSLAE 652
+R E
Sbjct: 1321 LREEREE 1327
Score = 67.4 bits (163), Expect = 4e-11
Identities = 101/462 (21%), Positives = 180/462 (38%), Gaps = 42/462 (9%)
Query: 221 RKADGQRQALDYVELSPLTQASPQRARTPARTPDRLAKQEELERDLAQRSEERRKWFEAT 280
RK + Q L E PL + R + ++ LE + R +ER + F
Sbjct: 1336 RKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKE 1395
Query: 281 DSRTPEVPAGEGPRRGLGAPLTEDQQNRLSEEIEKKWQELEKLPLRENKRVPLTALLNQS 340
+ + + R+ E++Q +E ++K++E E+ R+ + Q
Sbjct: 1396 EQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQL 1455
Query: 341 RGERRGPPSDGHEAL-EKEVQALRAQLEAWRLQGEAPQSALRSQEDGHIPPGYISQEACE 399
R ER + + L E+E Q L Q + E Q LR QE ++ E
Sbjct: 1456 RQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQ--LRRQER--------DRKFRE 1505
Query: 400 RSLAEMESSHQQVMEELQRHHERELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSR 459
+ L E + + EE Q H ++ ++ QE++ L +E K +E+L +
Sbjct: 1506 QELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQ 1565
Query: 460 ELSKTRSLQQGPDGLRKQHQSDVEALKRELQVLSEQYSQKCLEIGALMRQAEERE-HTLR 518
E + + +Q D + + V ++E + + ++ + E +RQ +R+
Sbjct: 1566 EREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDE 1625
Query: 519 RCQQEGQELLRHNQELHGRLSEEIDQLRGFIASQGMGNGCGR------------------ 560
+ QE +E H QE + EE QLR Q + + R
Sbjct: 1626 QLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLR 1685
Query: 561 --SNERSSCELEVLLRVKENELQYLKKEVQCLRDEL--------QMMQKDKRFTSGKYQD 610
+R E E LR +E E ++L++E Q R EL Q+ Q+ ++ + +
Sbjct: 1686 RQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQER 1745
Query: 611 VYVELSHIKTRSEREIEQLKEHLRLAMAALQEKESMRNSLAE 652
L + R ERE +QL+ R +E+E +R E
Sbjct: 1746 YRKILEEEQLRPEREEQQLRRQER--DRKFREEEQLRQEREE 1785
Score = 67.0 bits (162), Expect = 5e-11
Identities = 109/453 (24%), Positives = 184/453 (40%), Gaps = 84/453 (18%)
Query: 240 QASPQRARTPARTPDRLAKQEELE-RDLAQRSEE----RRKWFEATDSR----------- 283
Q ++ R A ++ KQE LE RD +R EE R++W E + R
Sbjct: 139 QKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKG 198
Query: 284 --TPEVPAGEGPRRGLGAPLT-----EDQQNR-------LSEEIEKKWQELEKLPLRENK 329
T E P E RR L E QQ R EE EK+W++ E + +E +
Sbjct: 199 HETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEE 258
Query: 330 RVPLTALLNQSRGERRGPPSDGHEALEK-EVQALRAQLEAWRLQGEAPQSALRSQEDGHI 388
+ L + +R+ + E L K E Q LR + R + E Q LR ++
Sbjct: 259 K------LQEEEPQRQRELQEEEEQLRKLERQELRRE----RQEEEQQQQRLRREQQ--- 305
Query: 389 PPGYISQEACERSLAEMESSHQQVMEELQRHHERELQRLQQEKEWLLAEETAATASAIEA 448
+ E E + ++ E ++ ER Q+L++E+E E E
Sbjct: 306 -----LRRKQEEERREQQEERREQQERREQQEERREQQLRREQE-----ERREQQLRREQ 355
Query: 449 MKKAYQEELSRELSKTRSLQQGPDGLRKQHQSDVEALKRELQVLSEQY---SQKCLEIGA 505
++ +++L RE + R QQ LR++ Q L+RE Q+ EQ Q+
Sbjct: 356 EEERREQQLRREQEEERREQQ----LRREQQ-----LRREQQLRREQQLRREQQLRREQQ 406
Query: 506 LMRQAE-------EREHTLRRCQQEGQELLRHNQE-LHGRLSEEIDQLRGFIASQGMGNG 557
L R+ + RE LRR Q+E + +H QE RL E ++ R ++ +
Sbjct: 407 LRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKRE----- 461
Query: 558 CGRSNERSSCELEVLLRVKENELQYLKKEVQCLRDELQMMQKDKRFTSGKYQDVYVELSH 617
ER E ++ E + ++ ++ +E + Q+ + + Q+ E
Sbjct: 462 --EETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQE---ERRE 516
Query: 618 IKTRSEREIEQLKEHLRLAMAALQEKESMRNSL 650
+ + + E E+L++ LR +E+E R L
Sbjct: 517 QRLKRQEEEERLQQRLRSEQQLRREQEERREQL 549
Score = 67.0 bits (162), Expect = 5e-11
Identities = 97/405 (23%), Positives = 168/405 (41%), Gaps = 30/405 (7%)
Query: 244 QRARTPARTPDRLAKQEELER---DLAQRSEERRKWFEATDSRTP------EVPAGEGPR 294
+R R RL ++ E ER +LA+ +E+ + E SR P E A
Sbjct: 660 KREEEEERLEQRLKREHEEERREQELAEEEQEQAR--ERIKSRIPKWQWQLESEADARQS 717
Query: 295 RGLGAPLTEDQQNRLSEEIEKKWQELEKLPLRENKRVPLTALLNQSRGERRGPPSDGHEA 354
+ P ++ Q R E+ EK+ + +L +E +R A Q E+R + +A
Sbjct: 718 KVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEER----AHRQQQEEEQRRDFTWQWQA 773
Query: 355 LEKEVQALRAQLEAWRLQGEAPQSALRSQE----DGHIPPGYISQEACERSLAEMESSHQ 410
EK + R +L A E + LR++E + P +E R E E
Sbjct: 774 EEKSERG-RQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKE-L 831
Query: 411 QVMEELQRHHERELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQQG 470
Q +EE ++ RE + QE+E L E+ S + + ++ +L E + R
Sbjct: 832 QFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYA 891
Query: 471 PDGLRKQHQSDVEALKRELQVLSEQYSQKCLEIGALMRQAEEREH-TLRRCQQEGQELLR 529
L++Q + + + L+ E + L + +K RQ +ER++ + QQE ++LLR
Sbjct: 892 KPALQEQLRKEQQLLQEEEEELQREEREK------RRRQEQERQYREEEQLQQEEEQLLR 945
Query: 530 HNQELHGRLSEEIDQLRGFIASQGMGNGCGRSNERSSCELEVLLRVKENELQYLKKEVQC 589
+E R E + Q G E+ + +E ELQ ++E Q
Sbjct: 946 EEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQ--QEEEQL 1003
Query: 590 LRDELQMMQKDKRFTSGKYQDVYVELSHIKTRSEREIEQLKEHLR 634
LR+E + ++ + + +D + R ERE +L+E R
Sbjct: 1004 LREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERER 1048
Score = 65.1 bits (157), Expect = 2e-10
Identities = 95/396 (23%), Positives = 161/396 (40%), Gaps = 61/396 (15%)
Query: 244 QRARTPARTPDRLAKQEELERDLAQRSEERRKW-FEATDSRTPEV----PAGEGPRRGLG 298
+RA+ D L + +E R QR +++ +W E R PA + R
Sbjct: 844 ERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQ 903
Query: 299 APLTEDQQNRLSEEIEKKWQELEKLPLRENKRVPLTA--LLNQSRGERRGPPSDGHEALE 356
L E+++ EE EK+ ++ ++ RE +++ LL + R +RR + +
Sbjct: 904 QLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKD 963
Query: 357 KEVQALRAQLEAWRLQGEAPQSALRSQ-EDGHIPPGYISQEACERSLAEMESSHQQVME- 414
K++Q QL GE P+ R + E + + QE + E E +Q E
Sbjct: 964 KKLQQKEEQL-----LGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWER 1018
Query: 415 ------ELQRHHE-------------------RELQRLQQEKEWLLAEETAATASAIEAM 449
ELQ+ E RE + LQQE+E LL EE
Sbjct: 1019 QYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRR------ 1072
Query: 450 KKAYQEELSRELSKTRSLQQGPDGLRKQHQSDVEALKRELQVLSEQYSQKCLEIGALMRQ 509
++EL R+ K LQQ + L ++ +RE Q E+ Q+ E L+R+
Sbjct: 1073 ----RQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQ--EEEQLLRE 1126
Query: 510 AEE--REHTLRRCQQEGQELLRHNQELHGRLSEEIDQLRGFIASQGMGNGCGRSNERSSC 567
E R L R +E +E+ + ++L L EE ++ R + R E
Sbjct: 1127 EREKRRRQELERQYREEEEVQQEEEQL---LREEPEKRRRQELERQY-----REEEELQQ 1178
Query: 568 ELEVLLRVKENELQYLKKEVQCLRDELQMMQKDKRF 603
E E LLR ++ + + ++ +ELQ ++ +R+
Sbjct: 1179 EEEQLLREEQEKRRQERERQYREEEELQRQKRKQRY 1214
Score = 63.9 bits (154), Expect = 4e-10
Identities = 83/392 (21%), Positives = 172/392 (43%), Gaps = 37/392 (9%)
Query: 258 KQEELER-DLAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAPLTEDQQNRLSEEIEKK 316
K+EE+ER + +R E+R K E + R ++ +E+Q+ R +++ ++
Sbjct: 603 KREEVERLEQEERREQRLKREEPEEERRQQLLK------------SEEQEERRQQQLRRE 650
Query: 317 WQELEKLPL-RENKRVPLTALLNQSRGERRGPPSDGHEALEKEVQALRAQLEAWRLQGEA 375
QE + L RE + L L + E R E E+ + +++++ W+ Q E+
Sbjct: 651 QQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLES 710
Query: 376 PQSALRSQEDGHIPPGYISQEACERSLAEMESSHQQVMEELQRHHERELQRLQQEKE--- 432
A +S+ ++ +R E E ++ ELQ E R QQE+E
Sbjct: 711 EADARQSKVYSR-----PRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRR 765
Query: 433 -----WLLAEETAATASAIEA---MKKAYQEELSRELSKTRSLQQGPDGLRK-QHQSDVE 483
W E++ + A +++ + +L E + R + P+ K Q +
Sbjct: 766 DFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRR 825
Query: 484 ALKRELQVLSEQYSQKCLEIGALMRQAEE--REHTLRRCQQEGQELLRHNQELHGRLSEE 541
++ELQ L E+ + E +++ E+ +E RR QE R +Q+ +L EE
Sbjct: 826 EREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQE----QRRDQKWRWQLEEE 881
Query: 542 IDQLRGFIASQGMGNGCGRSNERSSCELEVLLRVKENELQYLKKEVQCLRDELQMMQKDK 601
+ R + ++ R ++ E E L+ +E E + +++ + R+E Q+ Q+++
Sbjct: 882 RKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEE 941
Query: 602 RFTSGKYQDVYVELSHIKTRSEREIEQLKEHL 633
+ + + + + R +++++Q +E L
Sbjct: 942 QLLREEREKRRRQERERQYRKDKKLQQKEEQL 973
Score = 63.5 bits (153), Expect = 6e-10
Identities = 107/467 (22%), Positives = 190/467 (40%), Gaps = 44/467 (9%)
Query: 204 KAGEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPARTPDRLAKQE--E 261
K ++R + + + K +R+ + E L + PQR R ++L K E E
Sbjct: 226 KQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQE 285
Query: 262 LERDLAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAPLTEDQQNRLSEEIEKKWQELE 321
L R+ + +++++ R + E RR E Q+ R +E E++ Q+L
Sbjct: 286 LRRERQEEEQQQQRLRREQQLRRKQ----EEERREQQEERREQQERREQQE-ERREQQLR 340
Query: 322 KLPLRENKRVPLTALLNQSRGERRGPPSDGHEALEKEVQALRAQLEAWRLQGEAPQSALR 381
RE + L + ERR + E+ Q LR + + R Q + LR
Sbjct: 341 ----REQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLR 396
Query: 382 SQEDGHIPPGYISQEACERSLA---EMESSHQQVMEELQRHHEREL--QRLQQEKE---- 432
++ ++ R E + +Q E ++ HE+E QRL++E+E
Sbjct: 397 REQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRD 456
Query: 433 WLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQQGPDGLRKQHQSDVEALKRELQVL 492
WL EE T + +K + E + R L+ + R+Q + + L+RE +
Sbjct: 457 WLKREEE--TERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEER 514
Query: 493 SEQYSQKCLEIGALMRQAEEREHTLRRCQQEGQELLRHNQELHGRLSEEIDQLRGFIASQ 552
EQ K E ++Q E LRR Q+E +E L +E RL +E + R
Sbjct: 515 REQ-RLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREE-EKRLEQERREQR------ 566
Query: 553 GMGNGCGRSNERSSCELEVLLRVKENELQYLKKEVQ------CLRDELQMM-QKDKRFTS 605
E+ ++L R +E Q LK+E + R+E++ + Q+++R
Sbjct: 567 -------LKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQR 619
Query: 606 GKYQDVYVELSHIKTRSEREIEQLKEHLRLAMAALQEKESMRNSLAE 652
K ++ E +SE + E+ ++ LR +E+ R E
Sbjct: 620 LKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEE 666
Score = 52.4 bits (124), Expect = 1e-06
Identities = 87/364 (23%), Positives = 150/364 (41%), Gaps = 69/364 (18%)
Query: 258 KQEELERDLAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAPLTEDQQNRLSEEIEKKW 317
+QE E+ L + EERR W + R E E RR L DQ+ EE ++W
Sbjct: 439 EQERREQRLKREQEERRDWLK----REEETERHEQERRK--QQLKRDQE----EERRERW 488
Query: 318 QELEKLPLRENKRVPLTALLNQSRGERRGPPSDGHEALEKEVQALRAQLEAWRLQGEAPQ 377
+LE+ RE + E+ Q LR + E R Q
Sbjct: 489 LKLEEEERREQQ--------------------------ERREQQLRREQEERR-----EQ 517
Query: 378 SALRSQEDGHIPPGYISQEACERSLAEMESSHQQVMEELQRHHERELQRLQQEKE----W 433
R +E+ + S++ R E + EE + ER QRL++E+E
Sbjct: 518 RLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQ 577
Query: 434 LLAEETAATASAI---------EAMKKAYQEELSRELSKTRSL-QQGPDGLRKQH--QSD 481
LL E + + +K+ E L +E + + L ++ P+ R+Q +S+
Sbjct: 578 LLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSE 637
Query: 482 VEALKRELQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQQEGQELLRHNQELHGRLSEE 541
+ +R+ Q+ EQ ++ +++ EE E +R ++E +E R QEL EE
Sbjct: 638 EQEERRQQQLRREQQERR----EQRLKREEEEERLEQRLKREHEE-ERREQEL---AEEE 689
Query: 542 IDQLRGFIASQGMGNGCGRSNERSSCELEVLLRVKENELQYLKKEVQCLR----DELQMM 597
+Q R I S+ +E + + +V R ++ E Q ++E + R ELQ
Sbjct: 690 QEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQ 749
Query: 598 QKDK 601
++++
Sbjct: 750 EEER 753
Score = 50.1 bits (118), Expect = 7e-06
Identities = 107/486 (22%), Positives = 181/486 (37%), Gaps = 81/486 (16%)
Query: 204 KAGEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQ--RARTPARTPDRLAKQEE 261
K E + E + R P K Q + E L Q Q R R L +Q
Sbjct: 1082 KEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYR 1141
Query: 262 LERDLAQRSEE---------RRKWFEATDSRTPEVPAGEGPRRGLGAPLTEDQQNRLSEE 312
E ++ Q E+ RR+ E E+ E L ++Q + +E
Sbjct: 1142 EEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEE-------EQLLREEQEKRRQE 1194
Query: 313 IEKKWQELEKLPLRENKRV-----PLTALLNQSRGERRGPPSDGHEALEKEVQALRAQLE 367
E++++E E+L ++ K+ + L Q E+ D + QLE
Sbjct: 1195 RERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLE 1254
Query: 368 AWRLQGEAPQSALR------------------SQEDGHIPPGYISQEACERSLAEMESSH 409
+L+ Q L+ Q D H P E E+ A+
Sbjct: 1255 DSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEE-QLEREEQKEAKRRDRK 1313
Query: 410 QQVMEELQRHHERELQRLQQ------EKEWLLAEETAATASAIEAMKKAYQEELSRELSK 463
Q ++L R E +R Q+ E+E LL E E +K +EEL R +
Sbjct: 1314 SQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEEL-RHQEQ 1372
Query: 464 TRSLQQGPDGLRKQHQSDVEALKRELQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQQE 523
R + LR+Q +RE + L E+ +C E R+ + R+ R+ ++E
Sbjct: 1373 GRKFLEEEQRLRRQ--------ERERKFLKEEQQLRCQE-----REQQLRQDRDRKFREE 1419
Query: 524 GQELLRHNQELHGRLSEEIDQL------RGFIASQGMGNGCGRSNERSSCELEVLLRVK- 576
Q+L R QE + EE Q+ R F+ + + R E E LL+ +
Sbjct: 1420 EQQLSR--QERDRKFREEEQQVRRQERERKFLEEE---QQLRQERHRKFREEEQLLQERE 1474
Query: 577 -------ENELQYLKKEVQCLRDELQMMQKDKRFTSGKYQDVYVELSHIKTRSEREIEQL 629
E + ++L++E Q R E +++ S + + ++E R +R+ + L
Sbjct: 1475 EQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFL 1534
Query: 630 KEHLRL 635
+E +L
Sbjct: 1535 QEEQQL 1540
Score = 49.7 bits (117), Expect = 9e-06
Identities = 90/421 (21%), Positives = 167/421 (39%), Gaps = 54/421 (12%)
Query: 189 KENALHSYSTQKGPLKAGEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRART 248
+E LH Q+ L+ +Q E RG R+ D R+ + +L
Sbjct: 1520 EEQQLHRQQRQRKFLQEEQQLRRQE---RGQQRRQDRDRKFREEEQLRQ----------- 1565
Query: 249 PARTPDRLAKQEE-----LERDLAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAPLTE 303
R +L++QE LE +R E+ RK+ E RR G
Sbjct: 1566 -EREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQL----------RRQEGQQQLR 1614
Query: 304 DQQNRLSEEIEKKWQELEKLPL--RENKRVPLTALLNQSRGERRGPPSDGHEALEKEVQA 361
+++R E E+ QE E+ L +E R L R ER + +E +
Sbjct: 1615 QERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQ 1674
Query: 362 LRAQLEAWRLQGEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQQVMEELQRHHE 421
L + E +L+ + R +E + L E + + EE Q+
Sbjct: 1675 LLQEGEEQQLRRQERDRKFREEE---------------QQLRRQERERKFLQEE-QQLRR 1718
Query: 422 RELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQQGPDGLRKQHQSD 481
+EL+R +E+E L E E +K +EE R + + L++ + + +
Sbjct: 1719 QELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQ 1778
Query: 482 VEALKRELQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQQEGQELLRHNQELHGRLSEE 541
+ + E Q+ S++ +K E L ++ EE++ LR Q++G+ Q +L E+
Sbjct: 1779 LRQEREEQQLRSQESDRKFREEEQLRQEREEQQ--LRPQQRDGKYRWEEEQL---QLEEQ 1833
Query: 542 IDQLRGFIASQGMGNGCGRSNERSSCELEVLLRVKENELQYLKKEVQCLRDELQMMQKDK 601
+LR Q + E+S E + L + +E + + ++E + + ++ QK++
Sbjct: 1834 EQRLRQERDRQYRAEEQFATQEKSRREEQELWQ-EEEQKRRQERERKLREEHIRRQQKEE 1892
Query: 602 R 602
+
Sbjct: 1893 Q 1893
>gi|115648142 centrosomal protein 164kDa [Homo sapiens]
Length = 1460
Score = 68.2 bits (165), Expect = 2e-11
Identities = 106/474 (22%), Positives = 187/474 (39%), Gaps = 89/474 (18%)
Query: 230 LDYVELSPLTQASPQRARTPARTPDR---LAKQEELERDLAQRSEERRKWFEATDSRTPE 286
LD LSP+ + ++A+ P D+ + Q+EL+ ++ EER P
Sbjct: 424 LDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDELQSKQSKGLEER------LSPPLPH 477
Query: 287 VPAGEGPRRGLGAPLTEDQQNRLSEEIEKKWQELEKLPLRENKRVPLTALLNQSRGERRG 346
+ P R L TE++ + E + +W+E E+L E+ L+ L+ R +
Sbjct: 478 EERAQSPPRSLA---TEEEPPQ-GPEGQPEWKEAEELG--EDSAASLSLQLSLQREQAPS 531
Query: 347 PPSDGHEALEKEVQALRAQLEAWRLQGEAPQSALRSQEDGHIPPGYISQEAC-------E 399
PP+ + E+ QA +L + + E P+ + + P S E E
Sbjct: 532 PPAACEKGKEQHSQA--EELGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSE 589
Query: 400 RSLAEMESSHQQVMEELQRH-------------------HERELQRLQQEKEWLLAEETA 440
+L ME + QV+E+ QRH E E+ RL Q+KE L+
Sbjct: 590 AALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLRE 649
Query: 441 ATASAIEAMKKAYQEELSRELSKTR-----SLQQGPDGLRKQHQSDVEALKRELQ----- 490
AIE + +EE S+ LS R S Q D +R + ++ ++ L+ EL+
Sbjct: 650 RLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKA 709
Query: 491 --VLSEQYSQKCLE------------IGALMRQAEEREHTLRRCQQEGQEL-------LR 529
EQ +++ LE A + A+E+ R Q EG+
Sbjct: 710 ERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEKE 769
Query: 530 HNQELHGRLSEEIDQLRGFIASQGMGNGCGRSNERSSCELEVLLRVKENELQYLKKEVQC 589
H+ EL RL ++ + S + + ++ +L+ L E+ + V
Sbjct: 770 HSAELE-RLCSSLEAKHREVVS-SLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAG 827
Query: 590 LRDELQMMQKDKRFTSGKYQDVYVELSHIKTRSEREIEQLKEHLRLAMAALQEK 643
EL + ++KR ++ ER ++++KE + MA +E+
Sbjct: 828 YEHELSSLLREKR-------------QEVEGEHERRLDKMKEEHQQVMAKAREQ 868
Score = 58.2 bits (139), Expect = 2e-08
Identities = 102/481 (21%), Positives = 200/481 (41%), Gaps = 46/481 (9%)
Query: 183 KLSDSNKENALHSYSTQKGPLKAGEQRAGSEVISRGGPRKADGQRQALDYV--ELSPLTQ 240
KL +E L + ++ L + +R + I R + + Q L ++ ++ TQ
Sbjct: 624 KLCQEEEEEILRLHQQKEQSLSSLRERL-QKAIEEEEARMREEESQRLSWLRAQVQSSTQ 682
Query: 241 ASPQRARTPARTPDRLAKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAP 300
A + R + ++E + A+R+ +K + + E+ A E +
Sbjct: 683 ADEDQIRAEQEASLQKLREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNA 742
Query: 301 LTEDQQNRLSEEIEKKWQELEKLPLRENKRVPLTALLNQSRGERRGPPSDGHEALEKEVQ 360
E +L E++E + +E L + L L + + R S +L+K++Q
Sbjct: 743 AKEKALQQLREQLEGERKEAVAT-LEKEHSAELERLCSSLEAKHREVVS----SLQKKIQ 797
Query: 361 ALRAQLEAWRLQGEAPQSALRSQEDGHIPPGYISQEAC-------------ERSLAEMES 407
+ + EA +LQ Q R + + GY + + ER L +M+
Sbjct: 798 EAQQKEEA-QLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKMKE 856
Query: 408 SHQQVMEELQRHHERELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSL 467
HQQVM + + +E E +R Q+ AE +E +++A++ REL R
Sbjct: 857 EHQQVMAKAREQYEAE-ERKQR------AELLGHLTGELERLQRAHE----RELETVRQE 905
Query: 468 Q-QGPDGLRKQHQSDVEALKRELQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQQEGQE 526
Q + + LR++H+ +R+LQ L + ++ A + E +E T RR E Q+
Sbjct: 906 QHKRLEDLRRRHREQ----ERKLQDLELDLETRAKDVKARLALLEVQEETARR---EKQQ 958
Query: 527 LLRHNQELHGRLSEEIDQLRGFIASQGMGNGCGRSNERSSCELEVLLRVK---ENELQYL 583
LL +++ + E + +Q +SN++ L+ L K E+++ L
Sbjct: 959 LLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLL 1018
Query: 584 KKEVQCLRDELQMMQKDKRFTSGKYQDVYVELSHIKTRSEREIEQLKEHLRLAMAALQEK 643
+ + Q L+ ++ + + ++V VE ++ E ++ E LR ++ Q K
Sbjct: 1019 QAQSQQLQKHFSSLEAEAQKKQHLLREVTVEENNASPHFEPDLH--IEDLRKSLGTNQTK 1076
Query: 644 E 644
E
Sbjct: 1077 E 1077
>gi|88196790 coiled-coil domain containing 88 [Homo sapiens]
Length = 1476
Score = 66.6 bits (161), Expect = 7e-11
Identities = 104/458 (22%), Positives = 182/458 (39%), Gaps = 60/458 (13%)
Query: 208 QRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPARTPDRL--------AKQ 259
Q +GS V ++ P KA G+R +L SP + A PQ T + P L A Q
Sbjct: 577 QESGSPVETQESPEKA-GRRSSLQ----SPASVAPPQGPGTKIQAPQLLGGETEGREAPQ 631
Query: 260 EELERD---LAQRSEERRKWFEATDSRTPEVPAGEGPRRGL----GAPLTEDQQNRLSEE 312
EL + L Q E + ++ + ++ EGP +GL G + RL
Sbjct: 632 GELVPEAWGLRQEGPEHKPG--PSEPSSVQLEEQEGPNQGLDLATGQAEAREHDQRLEGT 689
Query: 313 I-EKKWQELEKLPLRENKRVPLTALLNQSRGERRGPPSDGHEALEKEVQALRAQLEAWRL 371
+ + WQ+ ++ + + + GE EAL +EV LR + EA
Sbjct: 690 VRDPAWQKPQQ---KSEGALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAEAL-- 744
Query: 372 QGEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQQVMEELQRHHERELQRLQQEK 431
G+ ++ R E + +S+E + AE E+ + + ++ RE ++
Sbjct: 745 -GDELEAQARKLEAQNTEAARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQE 803
Query: 432 EWLLAEETAATASAIEAM---KKAYQEELSRELSKTRSLQQGPDGLR---KQHQSDVEAL 485
++E A A+ A ++ ++ E SR +++ + ++ L +QH + E
Sbjct: 804 LESASQEREALVEALAAAGRERRQWEREGSRLRAQSEAAEERMQVLESEGRQHLEEAERE 863
Query: 486 KRELQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQQEGQELLRHNQELHGRLSEEIDQL 545
+RE + L + + + L + E + L + E QE LR + H R
Sbjct: 864 RREKEALQAELEKAVVRGKELGARLEHLQRELEQAALERQEFLREKESQHQRY------- 916
Query: 546 RGFIASQGMGNGCGRSNERSSCELEVLLRVKENELQYLKKEVQCLRDELQMMQKDKRFTS 605
QG+ +R EL+ KE L LK L +EL +++
Sbjct: 917 ------QGL-------EQRLEAELQAAATSKEEALMELKTRALQLEEELFQLRQGPAGLG 963
Query: 606 GKYQDVYVELSHIKTRSER--EIEQLKEHLRLAMAALQ 641
K + E ++T++ R E+E+ L AALQ
Sbjct: 964 PKKR---AEPQLVETQNVRLIEVERSNAMLVAEKAALQ 998
Score = 49.3 bits (116), Expect = 1e-05
Identities = 72/338 (21%), Positives = 134/338 (39%), Gaps = 29/338 (8%)
Query: 321 EKLPLRENKRVPLTALLNQSRGER-RGPPSDGHEALEKEVQALRAQLEAWRLQGEAPQSA 379
EK R + + P + Q G + + P G E +E EAW L+ E P+
Sbjct: 590 EKAGRRSSLQSPASVAPPQGPGTKIQAPQLLGGETEGREAPQGELVPEAWGLRQEGPE-- 647
Query: 380 LRSQEDGHIPPGYISQEACERSLAEMESSHQQVMEELQRHHERELQRLQQEKEWLLAEET 439
+ G P + E E ++ + Q R H++ L+ ++ W ++
Sbjct: 648 ---HKPGPSEPSSVQLEEQEGPNQGLDLATGQAEA---REHDQRLEGTVRDPAWQKPQQK 701
Query: 440 AATASAIEAMKKAYQ-EELSRELSKTRSLQQGPDGLRKQHQS---DVEALKRELQVLSEQ 495
+ A ++ + E L+ +++ +L++ LR++ ++ ++EA R+L+ + +
Sbjct: 702 SEGALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAEALGDELEAQARKLEAQNTE 761
Query: 496 YSQKCLEIGALMRQAEEREHTLRRCQQEGQELLRHNQELHGRLSEEIDQLRGFIASQGMG 555
++ E+ A R+AE H Q Q LR E G+ E Q R +
Sbjct: 762 AARLSKEL-AQARRAEAEAHREAEAQAWEQARLREAVEAAGQELESASQEREALVEALAA 820
Query: 556 NGCGRSN-ERSSCELEVLLRVKENELQYLKKEVQCLRDELQMMQKDKRFTSGKYQDVYVE 614
G R ER L E +Q L+ E + +E + +++K + + V
Sbjct: 821 AGRERRQWEREGSRLRAQSEAAEERMQVLESEGRQHLEEAERERREKEALQAELEKAVVR 880
Query: 615 -------LSHIKTRSEREIEQLKEHLRLAMAALQEKES 645
L H++ E+ + +E LR EKES
Sbjct: 881 GKELGARLEHLQRELEQAALERQEFLR-------EKES 911
Score = 48.1 bits (113), Expect = 2e-05
Identities = 98/460 (21%), Positives = 191/460 (41%), Gaps = 60/460 (13%)
Query: 224 DGQRQALDYVELSPLTQASPQRARTPARTPDRLAKQEELERDLAQRSEERRKW------- 276
+ + QA + L +A+ Q + ++ ++E L LA ERR+W
Sbjct: 782 EAEAQAWEQARLREAVEAAGQELESASQ------EREALVEALAAAGRERRQWEREGSRL 835
Query: 277 ---FEATDSRTPEVPAGEGPRRGLGAPLTEDQQNRLSEEIEKK--------------WQE 319
EA + R +V EG + A ++ L E+EK +E
Sbjct: 836 RAQSEAAEERM-QVLESEGRQHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQRE 894
Query: 320 LEKLPL--------RENKRVPLTALLNQSRGERRGPPSDGHEAL-EKEVQALRAQLEAWR 370
LE+ L +E++ L + E + + EAL E + +AL+ + E ++
Sbjct: 895 LEQAALERQEFLREKESQHQRYQGLEQRLEAELQAAATSKEEALMELKTRALQLEEELFQ 954
Query: 371 L-QGEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQQVMEELQRHHERELQRLQQ 429
L QG A + E + + ERS A + + + +LQ H E +L LQ
Sbjct: 955 LRQGPAGLGPKKRAEPQLVETQNVRLIEVERSNAMLVAEKAALQGQLQ-HLEGQLGSLQG 1013
Query: 430 EKEWLL-----AEETAATASAIEAMKKAYQEELSRELS----KTRSLQQGPDGLRKQHQS 480
+ LL A+E ++ A +++ + +EL R+L + R+ +Q + R Q Q
Sbjct: 1014 RAQELLLQSQRAQEHSSRLQAEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQ- 1072
Query: 481 DVEALKRELQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQQEGQELLRHNQELHGRLSE 540
AL R+ + L++ ++ E+ L+ + + + +R + +EL +++L + +
Sbjct: 1073 ---ALLRDHKALAQLQRRQEAELEGLLVRHRDLKANMRALELAHRELQGRHEQLQAQRAS 1129
Query: 541 EIDQLRGFIASQGMGNGCGRSNERSSCELEVLLRVKENELQYLKKEVQCLRDELQMMQKD 600
Q +A + G EL L+ + + Q L E+ R ELQ + +
Sbjct: 1130 VEAQEVALLAERERLMQDGHRQRGLEEELR-RLQSEHDRAQMLLAELSRERGELQGERGE 1188
Query: 601 KRFTSGKYQDVYVELSHIKTRSEREIEQLKEHLRLAMAAL 640
R G+ + +E + ++ +S+ ++ + + L L+ L
Sbjct: 1189 LR---GRLARLELERAQLEMQSQ-QLRESNQQLDLSACRL 1224
Score = 30.4 bits (67), Expect = 5.3
Identities = 51/210 (24%), Positives = 79/210 (37%), Gaps = 33/210 (15%)
Query: 390 PGYISQEACERSLAEMESSHQQVMEELQRHHERELQRLQQEKEWLLAEETAATASAIEAM 449
P + EA R+ AE S H + + R L++ +EK LL + A
Sbjct: 236 PLCLRPEAPSRAPAEGPSHHLALQLANAKAQLRRLRQELEEKAELLLDSQAEV------- 288
Query: 450 KKAYQEELSRELSKTRSLQQGPDGLRKQHQSDVEALKRELQVLSEQYSQKCLEIGALMRQ 509
+ L E+ + R Q G K+ E + E + L E+ G L R
Sbjct: 289 -----QGLEAEIRRLRQEAQALSGQAKR----AELYREEAEALRER-------AGRLPRL 332
Query: 510 AEEREHTLRRCQQEGQELLRHNQELHGR--LSEEIDQLRGFIASQ--GMGNGCGRSNE-- 563
EE LRRC++ Q + +L LS ++ + + Q C R +E
Sbjct: 333 QEE----LRRCRERLQAAEAYKSQLEEERVLSGVLEASKALLEEQLEAARERCARLHETQ 388
Query: 564 RSSCELEVLLRVKENELQYLKKEVQCLRDE 593
R + L L EL L+ +V L +E
Sbjct: 389 RENLLLRTRLGEAHAELDSLRHQVDQLAEE 418
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 65.9 bits (159), Expect = 1e-10
Identities = 109/481 (22%), Positives = 191/481 (39%), Gaps = 112/481 (23%)
Query: 250 ARTPDRLAKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAPLTEDQQNRL 309
+RT DRLA+ EE ++ +Q+ +E+++ E+ ++ L
Sbjct: 1116 SRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQK------------KINEIENL 1163
Query: 310 SEEIEKKWQELEKLPLRENKRVPLTALLNQSRGERRGPPSDGH--EALEKEVQALRAQLE 367
E++ K LE + E +R+ L LN++ E + + + L+K + R L
Sbjct: 1164 KNELKNKELTLEHM---ETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLR 1220
Query: 368 AWRLQGEAPQSALRSQEDGHIPPGYISQ-----EACERSLAE----------MESSHQQV 412
+ + EA + L+++E+ I ++ + + RS++E +E SH ++
Sbjct: 1221 GYIREIEA--TGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKL 1278
Query: 413 MEELQRHHER-----------ELQRLQQEKEWLLAEET---AATASAIEAMKKAYQEELS 458
EE+ HE E Q E E L + T + T + IE + E+
Sbjct: 1279 QEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQ 1338
Query: 459 RELSKTRSLQQGPDGLR-------------KQHQSDVEALKRELQVLSEQ------YSQK 499
+ +SL + D L+ K+H + A +E Q EQ +
Sbjct: 1339 ESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNE 1398
Query: 500 CLEIGALMRQAEEREHTLRRCQQEGQELLRHNQELHGR-----------------LSEEI 542
+I + M Q + ++ L R + E L + QE H L E
Sbjct: 1399 TTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSES 1458
Query: 543 DQLRGFI-----------ASQGMGNGCGRSNERSSCELEVLLRVKENELQYLKKEVQCLR 591
DQL+ I + + C + E + EL V L KE E+ ++K+++ +
Sbjct: 1459 DQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAIN 1518
Query: 592 DELQMMQKDKRFTSGKYQDVY--VELSHIKTRSE-----REIEQLKEHLRLAMAALQEKE 644
D+LQ K Q++Y E +IK SE E++Q KEH + +ALQ E
Sbjct: 1519 DKLQ----------NKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIE 1568
Query: 645 S 645
S
Sbjct: 1569 S 1569
Score = 48.9 bits (115), Expect = 1e-05
Identities = 82/332 (24%), Positives = 146/332 (43%), Gaps = 61/332 (18%)
Query: 355 LEKEVQALRAQLEAWRLQGEA--PQSALRSQEDGHI--PPGYISQEACERSLAEMESSHQ 410
L++ ++ E RL G+ Q + +QE H G +S+ C+R LAE+E +
Sbjct: 1073 LKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSR-TCDR-LAEVEEKLK 1130
Query: 411 QVMEELQRHHERELQRLQQEKEWLLAEETAATASAIEAMKKAYQ-EELSRELSKTRSLQQ 469
+ ++LQ E++ Q L ++E E + IE +K + +EL+ E +T L+
Sbjct: 1131 EKSQQLQ---EKQQQLLNVQEEM---SEMQKKINEIENLKNELKNKELTLEHMETERLEL 1184
Query: 470 GPDGLRKQHQSDVEALKRELQVLSEQYSQKCLEIGALMRQAEEREHT---LRRCQQEGQE 526
++ +V+++ +E +VL E QK E ER+H +R + G +
Sbjct: 1185 AQK--LNENYEEVKSITKERKVLKEL--QKSFET--------ERDHLRGYIREIEATGLQ 1232
Query: 527 LLRHNQELHGRLSEE---IDQLRGFIASQGMGNGCGRSNERSSCEL-----------EVL 572
+ H L E ID+LR ++ + + E+S +L E+L
Sbjct: 1233 TKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELL 1292
Query: 573 LRVKE--------NELQYL------KKEVQCLRDELQMMQKDKRFTSGKYQDVYV----- 613
VKE NEL+ L K R E++ ++ +++F + + +
Sbjct: 1293 PNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERD 1352
Query: 614 ELSHIKTRSEREIEQLKEHLRLAMAALQEKES 645
L IK E + +QLKEH+R +A +QE +S
Sbjct: 1353 NLKTIKEALEVKHDQLKEHIRETLAKIQESQS 1384
Score = 44.3 bits (103), Expect = 4e-04
Identities = 71/330 (21%), Positives = 143/330 (43%), Gaps = 48/330 (14%)
Query: 358 EVQALRAQLEAWRLQGEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQQVMEELQ 417
EVQ +L+ ++ +A SAL+S E + QE+ E Q+M + +
Sbjct: 1542 EVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEI---------QIMIKEK 1592
Query: 418 RHHERELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQQGPDGLRKQ 477
+R + LQ E++ L A E+ +K YQ +++T+ + L++Q
Sbjct: 1593 EEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQ 1652
Query: 478 HQS---DVEALKRELQVLSEQYSQKCLEIGALMRQAEER---EHTLRRCQQEGQELLRHN 531
++ ++E ++ E L++ + E+ ++ ++ ++ E TL+ + + +E LR
Sbjct: 1653 FETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRET 1712
Query: 532 --------QEL---HGRLSEE---IDQLRGFIASQ-----GMGNGCGRSNERSSCE---L 569
+EL H L E ID+LRG ++ + M SN+ + +
Sbjct: 1713 ITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKI 1772
Query: 570 EVLLRVKENELQYLKKEVQCLR-------DELQMMQKDKRFTSGKYQDVYVELSHIKTRS 622
+ LR+ L+ ++ + LR D+L MQKD ++ K Q+ EL +
Sbjct: 1773 QEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELK----AN 1828
Query: 623 EREIEQLKEHLRLAMAALQEKESMRNSLAE 652
E ++ LK+ + + E E ++ + +
Sbjct: 1829 EHQLITLKKDVNETQKKVSEMEQLKKQIKD 1858
Score = 41.2 bits (95), Expect = 0.003
Identities = 58/284 (20%), Positives = 116/284 (40%), Gaps = 51/284 (17%)
Query: 395 QEACERSLAEMESSHQQVMEELQRHHERELQRLQQEKEWLLAEETAATASAIEAMKKAYQ 454
+EA E +++ ++ + ++Q ++ Q L +++ ET S +E K
Sbjct: 1358 KEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEK---DNETTKIVSEMEQFKPKDS 1414
Query: 455 EELSRE---LSKTRSLQQGPDGLRK--QHQSDVEALKRELQVLSEQYSQKCLEIGALMRQ 509
L E L ++ LQ+ D ++ + + D++ L+ LQ S+Q + EI A +
Sbjct: 1415 ALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLE 1474
Query: 510 AEEREHTLRRCQQEGQELLRHNQELHGRLSEEIDQLRGFIASQGMGNGCGRSNERSSCEL 569
EE C +E +E + EL LSE+ ++ N ++ + E
Sbjct: 1475 TEEELKVAHCCLKEQEETIN---ELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEK 1531
Query: 570 EVLLRVKE--------NELQYLKKE---------------------VQCLRDELQMMQKD 600
E +K+ NEL+ K+ +Q ++E+Q+M K+
Sbjct: 1532 EEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKE 1591
Query: 601 KRFTSGKYQDVYVELSHIKTRSEREIEQLKEHLRLAMAALQEKE 644
K E+ ++ + E +QLKE+ + +A ++E +
Sbjct: 1592 KE-----------EMKRVQEALQIERDQLKENTKEIVAKMKESQ 1624
Score = 38.9 bits (89), Expect = 0.015
Identities = 71/392 (18%), Positives = 162/392 (41%), Gaps = 68/392 (17%)
Query: 309 LSEEIEKKWQELEKLPLRENKRVPLTALLNQSRGERRGPPSDGHEALEKEVQ-------- 360
L +E++ + E+ KL + +VP L N E G +D + L KEV+
Sbjct: 686 LEKELQSAFNEITKLTSLIDGKVPKDLLCNL---ELEGKITDLQKELNKEVEENEALREE 742
Query: 361 --------ALRAQLEAWR--LQGEAPQSALRSQEDGHIPPGYISQEA-----------CE 399
+L +++E R +Q ++ + + + E + + +E+ +
Sbjct: 743 VILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTK 802
Query: 400 RSLAEMESSHQQVMEELQRHH------ERELQRLQQEKEWL------LAEETAATASAIE 447
LA +S+++ +E Q E++ + + +E E + L++E S++
Sbjct: 803 DDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLG 862
Query: 448 AMKKAYQEELSRELSKTRSLQQGPDGLRK------QHQSDVEALKRELQVLSEQYSQKCL 501
A+K + KTR +Q+ + + + S ++ ++RE +++E+ Q
Sbjct: 863 ALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLE 922
Query: 502 EIGALMRQAEEREHTLRRCQQEGQELLRHNQELHGRLSEEID---QLRGFIASQGMGNGC 558
E+ L ++ ++ + Q E +L ++H ++ ID QLR + S
Sbjct: 923 EVKTLTQEKDDLKQLQESLQIERDQL---KSDIHDTVNMNIDTQEQLRNALESL------ 973
Query: 559 GRSNERSSCELEVLLRVKENELQYLKKEVQCLRDELQMMQKDKRFTSGKYQDVYVELSHI 618
+ ++ + L+ + + + ++++ +DE Q K K QD+ + +
Sbjct: 974 -KQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQ----QKMVGIDKKQDLEAKNTQT 1028
Query: 619 KTRSEREIEQLKEHLRLAMAALQEKESMRNSL 650
T ++ ++ E R + +QEK ++ L
Sbjct: 1029 LTADVKD-NEIIEQQRKIFSLIQEKNELQQML 1059
Score = 38.1 bits (87), Expect = 0.026
Identities = 72/371 (19%), Positives = 152/371 (40%), Gaps = 47/371 (12%)
Query: 303 EDQQNRLSEEIE---KKWQELEKLP--LRENKRVPLTALLNQSRGERRGPPSDGHEALEK 357
+D +N LS ++E +K +++KL + K + L+ S P +
Sbjct: 571 QDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDA 630
Query: 358 EVQALRAQLEAWRLQGEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQQVMEELQ 417
E AL A+ E+ L+ E + + + E+ ++++Q+ ++Q
Sbjct: 631 ETVALDAKRESAFLRSENLE--------------------LKEKMKELATTYKQMENDIQ 670
Query: 418 RHHERELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQQGPDGLRKQ 477
+ + + + + + L +E + + I + ++ ++L L+ L+K+
Sbjct: 671 LYQSQLEAKKKMQVD--LEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKE 728
Query: 478 HQSDVE---ALKRELQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQQEGQELLR---HN 531
+VE AL+ E+ +LSE S E+ L ++ +++ L E +L H
Sbjct: 729 LNKEVEENEALREEVILLSELKSLPS-EVERLRKEIQDKSEELHIITSEKDKLFSEVVHK 787
Query: 532 QELHGRLSEEIDQLRGFIASQGMGNGCGRSNERSSCELEVLLRVKENELQYLKKEVQCLR 591
+ L EEI + + +A+ +S ++ + L E + + + +E + +
Sbjct: 788 ESRVQGLLEEIGKTKDDLATTQSNY---KSTDQEFQNFKTLHMDFEQKYKMVLEENERMN 844
Query: 592 DELQMMQKDKRFTSGKYQDVYVELSHI------KTRSERE----IEQLKEHLRLAMAALQ 641
E+ + K+ + + ELS+ KTR +E +EQLKE L + LQ
Sbjct: 845 QEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQ 904
Query: 642 EKESMRNSLAE 652
E + + E
Sbjct: 905 TVEREKTLITE 915
Score = 38.1 bits (87), Expect = 0.026
Identities = 58/296 (19%), Positives = 132/296 (44%), Gaps = 53/296 (17%)
Query: 395 QEACERSLAEMESSHQQVMEELQRHHERELQRLQQEKEWL--LAEETAATASAIEAMKKA 452
Q+ E ++++ Q++ E+ ++ + +++ +Q++ L E A SA+++++
Sbjct: 1511 QKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIE-- 1568
Query: 453 YQEELSRELSKTRSLQQGPDGLRK--QHQSDVEALKRELQVLSEQYSQKCLEIGALMRQA 510
S+ L T LQ+ + ++ + + +++ ++ LQ+ +Q + EI A M+++
Sbjct: 1569 -----SKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKES 1623
Query: 511 EEREHTLRRC------------------QQEGQEL---------LRHNQELHGRLSE--- 540
+E+E+ + Q E Q+L +R Q LH L E
Sbjct: 1624 QEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRS 1683
Query: 541 ---EIDQLRGFIASQGMGNGCGRSNERSSCELEVLLRVKENELQYLK---KEVQCLRDEL 594
E D LR + + + N R + ++ K+ EL+ + KE Q D+L
Sbjct: 1684 VTKERDDLRSVEETLKVERDQLKENLRETITRDL---EKQEELKIVHMHLKEHQETIDKL 1740
Query: 595 QMMQKDKRFTSGKYQDVYVELSHIKTRSEREIEQLKEHLRLAMAALQEKESMRNSL 650
+ + +K + + ++ +L H + + +++E LR+A L+E++ + L
Sbjct: 1741 RGIVSEK---TNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKL 1793
Score = 37.4 bits (85), Expect = 0.044
Identities = 60/307 (19%), Positives = 125/307 (40%), Gaps = 44/307 (14%)
Query: 352 HEALEKEVQALRAQLEAWR-----LQGEAPQSA------LRSQEDGHIPPGYISQEACER 400
++ +E ++Q ++QLEA + L+ E QSA L S DG +P + E
Sbjct: 662 YKQMENDIQLYQSQLEAKKKMQVDLEKEL-QSAFNEITKLTSLIDGKVPKDLLCNLELEG 720
Query: 401 SLAEMESSHQQVMEELQRHHERELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRE 460
+ +++ + +EE + E E +L E + S +E ++K Q++ S E
Sbjct: 721 KITDLQKELNKEVEENEALRE----------EVILLSELKSLPSEVERLRKEIQDK-SEE 769
Query: 461 LSKTRSLQQGPDGLRKQHQSDVEALKRELQVLSEQYSQKCLEIGALMRQAEEREHTLRRC 520
L S + +S V+ L E+ + + + ++ + +
Sbjct: 770 LHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDF 829
Query: 521 QQEGQELLRHNQELHGRLSEEIDQLRGFIASQGMGNGCGRSNERSSCELEVLLRVKENEL 580
+Q+ + +L N+ ++ + + + F +S G L+ L K EL
Sbjct: 830 EQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGA--------------LKTELSYKTQEL 875
Query: 581 QYLKKEVQCLRDELQMMQKDKRFTSGKYQDVYVELSHIKTRSEREIEQLKEHLRLAMAAL 640
Q +EVQ +E++ +++ Q V E + I + ++ +E++K
Sbjct: 876 QEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVK-------TLT 928
Query: 641 QEKESMR 647
QEK+ ++
Sbjct: 929 QEKDDLK 935
Score = 37.0 bits (84), Expect = 0.057
Identities = 79/332 (23%), Positives = 138/332 (41%), Gaps = 53/332 (15%)
Query: 332 PLTALLNQSRGERRGPPSDGHEALEKEVQALRAQ-----LEAWRLQGEAPQSALRSQEDG 386
P T LLNQ E +E E+ +LRA L+ +L+ E + L+ +E
Sbjct: 486 PATKLLNQ-------------ENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKN 532
Query: 387 HIPPGYISQEACERSLA---EMESSHQ-QVMEELQRHHERELQRLQQE---KEWLLAEET 439
+ EA ER EM+ H+ ++ L +H E Q L+ E K LL E+
Sbjct: 533 DLD----EFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKE 588
Query: 440 AATASAIEAMKKAYQEELSRELSKTRSLQQGPDGLRKQHQSDVEAL----KRELQVLSEQ 495
E + E + +LS + + P + KQ D E + KRE L +
Sbjct: 589 DQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQM-KQTLFDAETVALDAKRESAFLRSE 647
Query: 496 ---YSQKCLEIGALMRQAEEREHTLRRCQQEGQELLRHNQELHGRLS-EEIDQLRGFIAS 551
+K E+ +Q E + L + Q E ++ ++ + E + + EI +L I
Sbjct: 648 NLELKEKMKELATTYKQMEN-DIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDG 706
Query: 552 QGMGNG-CGRSNERSSCELEVLLR--VKENE-----------LQYLKKEVQCLRDELQMM 597
+ + C E +L+ L V+ENE L+ L EV+ LR E+Q
Sbjct: 707 KVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDK 766
Query: 598 QKDKRFTSGKYQDVYVELSHIKTRSEREIEQL 629
++ + + ++ E+ H ++R + +E++
Sbjct: 767 SEELHIITSEKDKLFSEVVHKESRVQGLLEEI 798
Score = 32.0 bits (71), Expect = 1.8
Identities = 68/381 (17%), Positives = 158/381 (41%), Gaps = 19/381 (4%)
Query: 256 LAKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAPLTEDQQNRLSEEIEK 315
L+K E +LAQ+ E + ++ + E + L E Q + ++E
Sbjct: 1863 LSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEI 1922
Query: 316 KWQELEKLPLRENKRVPLTALLNQSRGERRGPPSDGHEALEKEVQALRAQLEAWRLQGEA 375
+ QEL+ + + L + E+ SD + L+K L+ +++ LQ +
Sbjct: 1923 Q-QELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQ--ELQKKE 1979
Query: 376 PQSALRSQEDGHIPPGYISQEACERSLAEMESSHQQVMEELQRHHERELQRLQQEKEWLL 435
Q LR +ED ++ I++ L + + M+ ++ + + ++L + E +
Sbjct: 1980 LQ-LLRVKEDVNMSHKKINEM---EQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIR 2035
Query: 436 AEETAATASAIEAMKKAYQEELSRELSKTRSLQQGPDGLRKQHQSDVEALKRELQVLSEQ 495
A + +K++ + E + ++ R + D Q + + L Q L+E
Sbjct: 2036 I--VAKERDELRRIKESLKMERDQFIATLREMI-ARDRQNHQVKPEKRLLSDGQQHLTES 2092
Query: 496 YSQKCLEIGALMRQAEERE---HTLRRCQQEGQELLRHNQELHGRLSEEIDQLRGFIASQ 552
+KC I L+++ E + L R + ++ + +EL R+ + ++ ++
Sbjct: 2093 LREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSL--PYLQTK 2150
Query: 553 GMGNGCGRSNERSSCELEVLLRVKENELQYLKKEVQCLRDELQMMQKDKRFTSGKYQDVY 612
+ +N+R S E +++ + L Y+ K + + + + D K +++
Sbjct: 2151 HIEK-LFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELL 2209
Query: 613 VELSHIKTRSE---REIEQLK 630
+++ H++ + RE+ LK
Sbjct: 2210 IKIQHLQQDCDVPSRELRDLK 2230
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 65.5 bits (158), Expect = 2e-10
Identities = 104/472 (22%), Positives = 187/472 (39%), Gaps = 59/472 (12%)
Query: 226 QRQALDYVELSPLTQASPQRARTPARTPDRLAKQEELERDLAQRSEERRKWFEATDSRTP 285
+++AL L + R A T +L ++++E DL E+ +K T+
Sbjct: 1044 EKKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVE-DLECSLEQEKKLRMDTERAKR 1102
Query: 286 EVPAGEGPRRGLGAPLTEDQQNRLSEEIEKKWQELEKLPLRENKRVPLTALLNQSRGERR 345
++ + A +D+Q +L E+++KK EL +L LR L A + + E +
Sbjct: 1103 KLEGDLKLTQESVADAAQDKQ-QLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQ 1161
Query: 346 GPPSDGHEALEKEVQALRAQLEAWRLQG--EAPQSALRSQEDGHIPPGYISQEACERSLA 403
+ E LE E +A RA++E R + E + + R +E G G +E C + A
Sbjct: 1162 ARAEELEEELEAE-RAARARVEKQRAEAARELEELSERLEEAGGASAG--QREGCRKREA 1218
Query: 404 EMESSHQQVMEELQRHHER--ELQRLQQEKEWLLAEETAATASAIEAMKK---------- 451
E+ +++ E RH L+R Q E L E+ + + ++K
Sbjct: 1219 ELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVD 1278
Query: 452 ---AYQEELSRELSKTRSLQQGPDGLRKQHQSDVEALKRELQVLSEQYSQKCLEIGALMR 508
A E L+R + L + + + + VE L+R+L S Q + E G L R
Sbjct: 1279 DLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSR 1338
Query: 509 QAEEREHTLRRCQQEGQELLRHNQELHGRLSEEIDQLRGFI-ASQGMGNGCGRSNE---- 563
EE+E + + + + +EL +L EE A Q + + C E
Sbjct: 1339 LLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEE 1398
Query: 564 ----------------------RSSCELEVLLRVKENE---------LQYLKKEVQCLRD 592
RS E + + R +E E LQ ++ V+
Sbjct: 1399 EAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANA 1458
Query: 593 ELQMMQKDKRFTSGKYQDVYVELSHIKTRSEREIEQLKEHLRLAMAALQEKE 644
+ ++K K + +DV +EL T + +++ + HL A+ + +E
Sbjct: 1459 KCSSLEKAKLRLQTESEDVTLELER-ATSAAAALDKKQRHLERALEERRRQE 1509
Score = 50.8 bits (120), Expect = 4e-06
Identities = 107/447 (23%), Positives = 171/447 (38%), Gaps = 72/447 (16%)
Query: 219 GPRKADGQRQALDYVELSPLTQASP-----QRARTPARTPDRLAKQEELERDLAQRSEER 273
G A+ + +L+ +L T++ +RA + A D+ KQ LER L EER
Sbjct: 1452 GVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDK--KQRHLERAL----EER 1505
Query: 274 RKWFEATDSRTPEVPAGEGPRRGLGAPLTEDQQNRLSEEIEKKWQELEKLPLRENKRVP- 332
R+ E E+ A + RGLG L RL E+ + LE L RENK +
Sbjct: 1506 RRQEEEMQR---ELEAAQRESRGLGTELF-----RLRHGHEEALEALETLK-RENKNLQE 1556
Query: 333 -LTALLNQSRGERRGPPSDGHEALEKEVQALRAQLEAWRLQGEAPQSALRSQEDGHIPPG 391
++ L +Q + + LEK +AL + + E + AL +E +
Sbjct: 1557 EISDLTDQVSLSGKSI-----QELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQ 1611
Query: 392 Y-ISQEACE--RSLAEMESSHQQVMEELQRHHERELQRLQQEKEWLLAEETAATASAIEA 448
+SQ E R LAE + L+R+H+R ++ LQ L ET A A+
Sbjct: 1612 LELSQVKAEVDRKLAEKDEE----CANLRRNHQRAVESLQAS----LDAETRARNEALRL 1663
Query: 449 MKKAYQEELSRELSKTRSLQQGPDGL----------------RKQHQSDVEALKRELQVL 492
KK + EL + +Q + R + Q L + Q L
Sbjct: 1664 KKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQAL 1723
Query: 493 SEQYSQKCLEIGALMRQAEEREHTLRRCQQEGQELLRHNQELHGRLSEEIDQLRGFIASQ 552
+ S E+ L E+ E + R +QE E LH + + ++Q + A
Sbjct: 1724 ERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADL 1783
Query: 553 GMGNGCGRSNERSSCELEVLLRVKENELQYLKKEVQCLRDELQMMQKDKRFTSGKYQDVY 612
+G E+E + + + KK + D M ++ K K QD
Sbjct: 1784 AQLSG----------EVEEAAQERREAEEKAKK---AITDAAMMAEELK-----KEQDTS 1825
Query: 613 VELSHIKTRSEREIEQLKEHLRLAMAA 639
L +K E+ + +L+ L A A
Sbjct: 1826 AHLERMKKTLEQTVRELQARLEEAEQA 1852
Score = 49.3 bits (116), Expect = 1e-05
Identities = 102/464 (21%), Positives = 181/464 (39%), Gaps = 52/464 (11%)
Query: 200 KGPLKAGEQRAGSEVISRGGPRKADGQRQALDYV--ELSPLTQASPQRARTPARTPDRLA 257
+G + GEQ + + + ++ R +D + + LT+A + D+L+
Sbjct: 1247 EGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLS 1306
Query: 258 ----KQEELERDLAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAPLTEDQQNRLSEEI 313
K EEL+R LA S +R G TE S E+
Sbjct: 1307 EAKIKVEELQRQLADASTQR------------------------GRLQTE------SGEL 1336
Query: 314 EKKWQELEKLPLRENKRVPLTALLNQSRGERRGPPSDGHEALEKEVQALRAQLEAWRLQG 373
+ +E E L + ++ L A + + S AL VQALR + R Q
Sbjct: 1337 SRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQH 1396
Query: 374 EAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQQVMEELQRHHERELQRLQQEKEW 433
E + A E + ++ A RS E ++ Q EEL+ ++ RLQ+ +E
Sbjct: 1397 E--EEAEAQAELQRLLSKANAEVAQWRSKYEADAI--QRTEELEEAKKKLALRLQEAEEG 1452
Query: 434 LLAEETAATASAIEAMKKAYQ---EELSRELSKTRSLQQGPDGLRKQHQSDVEALKRELQ 490
+ E A S++E K Q E+++ EL + S D ++ + +E +R+ +
Sbjct: 1453 V--EAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEE 1510
Query: 491 VLSEQYSQKCLEIGALMRQAEEREHTLRRCQQEGQELLRHNQELHGRLSEEIDQLRGFIA 550
+ + E L + H + + L R N+ L +S+ DQ+
Sbjct: 1511 EMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGK 1570
Query: 551 SQGMGNGCGRSNERSSCELEVLLRVKENELQYLKKEVQCLRDELQMMQKDKRFTSGKYQD 610
S ++ E E++ L E L+ +E + LR +L++ Q K K +
Sbjct: 1571 SIQELEKTKKALEGEKSEIQAALEEAEGALEL--EETKTLRIQLELSQV-KAEVDRKLAE 1627
Query: 611 VYVELSHIKTRSEREIEQLKEHL----RLAMAALQEKESMRNSL 650
E ++++ +R +E L+ L R AL+ K+ M L
Sbjct: 1628 KDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDL 1671
Score = 42.4 bits (98), Expect = 0.001
Identities = 70/308 (22%), Positives = 131/308 (42%), Gaps = 29/308 (9%)
Query: 261 ELERDLAQRSEE----RRKWFEATDSRTPEVPAGEGPRRGLGAPLTEDQQNRLSE-EIEK 315
E++R LA++ EE RR A +S + A E R L + + L++ E++
Sbjct: 1620 EVDRKLAEKDEECANLRRNHQRAVESLQASLDA-ETRARNEALRLKKKMEGDLNDLELQL 1678
Query: 316 KWQELEKLPLRENKRVPLTALLNQSRG--ERRGPPSDGHE---ALEKEVQALRAQLEAWR 370
+ + R+ L + G E + ++ HE ALE+ L A+LE R
Sbjct: 1679 GHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELR 1738
Query: 371 L---QGE-----APQSALRSQEDGHI----PPGYISQEA-CERSLAEMESSHQQVMEELQ 417
QGE A Q L + E ++ G ++Q+ E LA++ ++ +E +
Sbjct: 1739 AALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERR 1798
Query: 418 RHHERELQRLQQEKEWLLAEETAA---TASAIEAMKKAYQEELSRELSKTRSLQQGPDGL 474
E+ + + ++AEE T++ +E MKK ++ + ++ +Q
Sbjct: 1799 EAEEKAKKAITDAA--MMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEEAEQAALRG 1856
Query: 475 RKQHQSDVEALKRELQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQQEGQELLRHNQEL 534
K+ +EA REL+ + +K E +R+ E R L +E ++ L Q+L
Sbjct: 1857 GKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKELAYQAEEDRKNLARMQDL 1916
Query: 535 HGRLSEEI 542
+L ++
Sbjct: 1917 VDKLQSKV 1924
Score = 40.0 bits (92), Expect = 0.007
Identities = 40/173 (23%), Positives = 81/173 (46%), Gaps = 20/173 (11%)
Query: 483 EALKRELQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQQEGQELLRHNQELHGRLSEEI 542
EA ++EL+ +Q+ ++ AL QAE+ L ++ L++ +L G++ E
Sbjct: 916 EAKRQELEETHVSITQEKNDL-ALQLQAEQ--DNLADAEERCHLLIKSKVQLEGKVKELS 972
Query: 543 DQLRGFIASQGMGNGCGRSNERSSCELEVLLRVKENELQYLKKEVQCLRDELQMMQKDKR 602
++L E + +L R E+E LKK++ L+ L +K+K+
Sbjct: 973 ERLE--------------DEEEVNADLAARRRKLEDECTELKKDIDDLKLTLAKAEKEKQ 1018
Query: 603 FTSGKYQDVYVELSHIK---TRSEREIEQLKEHLRLAMAALQEKESMRNSLAE 652
T K +++ E++ + R +E + L+E + A+ LQ +E ++L +
Sbjct: 1019 ATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTK 1071
Score = 38.5 bits (88), Expect = 0.020
Identities = 61/306 (19%), Positives = 129/306 (42%), Gaps = 21/306 (6%)
Query: 356 EKEVQALRAQLEAWRLQGEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQQVMEE 415
E+E+ ALRA+L R A ++ + E+ H+ I+QE + +L ++++ + +
Sbjct: 895 EEELAALRAELRGLRGALAAAEAKRQELEETHVS---ITQEKNDLAL-QLQAEQDNLADA 950
Query: 416 LQRHH-----ERELQRLQQEKEWLLAEETAATASAIEAMKKAYQE--ELSRELSKTRSLQ 468
+R H + +L+ +E L +E A +K E EL +++ +
Sbjct: 951 EERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTL 1010
Query: 469 QGPDGLRKQHQSDVEALKRELQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQQEGQELL 528
+ ++ ++ V+ L E+ L E ++ E AL E + L Q E ++ +
Sbjct: 1011 AKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQ---EAHQQALGDLQAE-EDRV 1066
Query: 529 RHNQELHGRLSEEIDQLRGFIASQGMGNGCGRSNERSSCELEVLLRVKENELQYLKKEVQ 588
+ RL ++++ L S ER+ +LE L++ + + ++ Q
Sbjct: 1067 SALTKAKLRLEQQVEDLE---CSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQ 1123
Query: 589 CLRDELQMMQKDKRFTSGKYQDVYVELSHIKTR---SEREIEQLKEHLRLAMAALQEKES 645
L ++L+ + S + +D + + ++ + + E+L+E L AA E
Sbjct: 1124 QLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEK 1183
Query: 646 MRNSLA 651
R A
Sbjct: 1184 QRAEAA 1189
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 63.5 bits (153), Expect = 6e-10
Identities = 107/484 (22%), Positives = 196/484 (40%), Gaps = 44/484 (9%)
Query: 207 EQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPARTPD-----RLAKQEE 261
+QR EV+ R Q++ EL L Q+S + AR + RL +EE
Sbjct: 1394 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1453
Query: 262 LE--RDLAQRSEERRKWFE----ATDSRTPEVPA----GEGPRRGLGAPLTEDQQNRLSE 311
+ R + +E +R E A +R E A + L + ++ Q +
Sbjct: 1454 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1513
Query: 312 EIEKKWQELEKLPLRENKRVPLTAL----LNQSRGERRGPPSDGHEA------LEKEVQA 361
E+E + + K+ L AL L ERR ++ A LE ++
Sbjct: 1514 EVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1573
Query: 362 LRAQLEAWRLQ-GEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQQVMEELQRHH 420
A+L++ R E RS ++ H+ + +EA R A+ ++ ++ EE +R
Sbjct: 1574 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR--AQQQAEAERAREEAEREL 1631
Query: 421 ER-ELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQQGPDGLRKQHQ 479
ER +L+ + + L AEE A S +A + +EE RE + ++ R+ +
Sbjct: 1632 ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1691
Query: 480 SDVEALKRELQVLSEQ---YSQKCLEIGALMRQAEER----EHTLRRCQQEGQELLRHNQ 532
++E ++ + ++Q Q+ + + A Q E++ E L R Q+E + Q
Sbjct: 1692 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ 1751
Query: 533 ELHGRLSEEIDQLRGFIASQGMGNGCGRS-NERSSCELEV---LLRVKENELQYLKKEVQ 588
EL L++ ++ +AS+ RS +E+S LE R E L+ +
Sbjct: 1752 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1811
Query: 589 CLRDELQMMQKDKRFTSGKYQDVYVELSHIKTRSEREIEQLKEHLRLAMAALQEKESMRN 648
+ + Q+ ++D + + V E K + E +LK +A+ + +
Sbjct: 1812 EAKRQRQLAEEDAARQRAEAERVLAE----KLAAIGEATRLKTEAEIALKEKEAENERLR 1867
Query: 649 SLAE 652
LAE
Sbjct: 1868 RLAE 1871
Score = 60.8 bits (146), Expect = 4e-09
Identities = 108/484 (22%), Positives = 198/484 (40%), Gaps = 67/484 (13%)
Query: 206 GEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPARTPDRLAKQEELERD 265
G Q G + R G R + +R +L QA + R ++L +Q R+
Sbjct: 1155 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE 1214
Query: 266 LAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAPLTEDQQNR--------LSEEIEKKW 317
A + W + R ++ A PL + Q R L EEIE+
Sbjct: 1215 SA---DPLGAWLQDARRRQEQIQA---------MPLADSQAVREQLRQEQALLEEIERHG 1262
Query: 318 QELE------KLPLRENKRVPLTALLNQSRGERRGPPS------DGHEALEKEVQALRAQ 365
+++E K + K L + +++ E P+ G E++ +E LR
Sbjct: 1263 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1322
Query: 366 L-EAWRLQGE----APQSALRSQEDGHIPPGYISQEACERS-LAEMESSHQQVMEELQRH 419
E L + ++ R +E+ + Q A ER LAE+E++ ++ + + H
Sbjct: 1323 YSELTTLTSQYIKFISETLRRMEEEERLAE---QQRAEERERLAEVEAALEKQRQLAEAH 1379
Query: 420 H------ERELQRLQQ--EKEWLLAEETAATASAIEAMKKAYQEELSR-------ELSKT 464
ERE + LQQ ++E + EE A A + K++ QEEL + E+
Sbjct: 1380 AQAKAQAEREAKELQQRMQEEVVRREEAAVDA---QQQKRSIQEELQQLRQSSEAEIQAK 1436
Query: 465 RSLQQGPDGLRKQHQSDVEALKRELQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQQEG 524
+ + R + + ++ ++ +L+ Q E+ AL +AEE E R+ Q+E
Sbjct: 1437 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1496
Query: 525 QELLRHNQELHGRLSEEIDQLRGFIASQGMGNGCGRSNERSSCELEVL-LRVKENELQYL 583
+ L R Q+ R + +L + ++ R +R+ LE L L+ +E E +
Sbjct: 1497 ERLRRQVQDESQRKRQAEVELASRVKAEA---EAAREKQRALQALEELRLQAEEAERRLR 1553
Query: 584 KKEVQCLRDELQMMQKDKRFTSGKYQDVYVELSHIKTRSEREIEQLKEHLRLAMAALQEK 643
+ EV+ R ++ +R + Q + + ER +++ EH +A+A L+E+
Sbjct: 1554 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE--EH--VAVAQLREE 1609
Query: 644 ESMR 647
R
Sbjct: 1610 AERR 1613
Score = 59.7 bits (143), Expect = 8e-09
Identities = 80/345 (23%), Positives = 137/345 (39%), Gaps = 50/345 (14%)
Query: 234 ELSPLTQASPQRARTPARTPDRLAKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEGP 293
E + Q + + AR + ++ E DLAQ+ K + E
Sbjct: 2269 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT----- 2323
Query: 294 RRGLGAPLTEDQQNRLSEEIEKKWQELEKLPLRENKRVPLTALLNQSRGERRGPPSDGHE 353
R A L + Q+ E+ + L+E+K L +++G +R ++
Sbjct: 2324 RLKAEAELLQQQKELAQEQARR---------LQEDKEQMAQQLAEETQGFQRTLEAERQR 2374
Query: 354 ALEKEVQALRAQL---EAWRLQGEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQ 410
LE +A R +L E R Q A + A R ++ I ++ LA E
Sbjct: 2375 QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE----EIGEKLHRTELATQEKVTL 2430
Query: 411 QVMEELQRHH---------------ERELQRLQQEKEWL-LAEETAATASA------IEA 448
E+QR ERE ++LQQE + L L E T +A
Sbjct: 2431 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2490
Query: 449 MKKAYQEELSRELSKTRSLQQGPDGLRKQHQSDV---EALKRELQVLSEQYSQKCLEIGA 505
+++++ E L + R ++Q L + Q +V + L+ E Q +Q Q+ + A
Sbjct: 2491 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2550
Query: 506 LMRQAEEREHT----LRRCQQEGQELLRHNQELHGRLSEEIDQLR 546
M +A R+H +RR Q+E Q+L + ++ L+EE +LR
Sbjct: 2551 SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2595
Score = 53.9 bits (128), Expect = 5e-07
Identities = 110/489 (22%), Positives = 192/489 (39%), Gaps = 67/489 (13%)
Query: 197 STQKGPLKAGEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPARTPDRL 256
S Q+ +AG R +E +R + +RQ E A+ QRA ++L
Sbjct: 1785 SKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE-----DAARQRAEAERVLAEKL 1839
Query: 257 AKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEG-PRRGLGAPLTEDQQNRLSEEIEK 315
A E R L +E K EA + R + E RR L E+Q + +IE+
Sbjct: 1840 AAIGEATR-LKTEAEIALKEKEAENERLRRLAEDEAFQRRRL-----EEQAAQHKADIEE 1893
Query: 316 KWQELEKLPLRENKRVPLTALLNQSRGERRGPPSDGHEALEKEVQALRA----------- 364
+ +L K E +R L+ + +RR +E+E+ AL+A
Sbjct: 1894 RLAQLRKASDSELERQK--GLVEDTLRQRR--------QVEEEILALKASFEKAAAGKAE 1943
Query: 365 -QLEAWRLQGEAPQSALRSQEDGHIPPGYISQEACE-------------RSLAEMESSHQ 410
+LE R++ A + LRS+E + Q A E +SLA E + +
Sbjct: 1944 LELELGRIRSNA-EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 2002
Query: 411 Q---VMEELQR------HHERELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSREL 461
Q +EE++R R +R +QE L A ++A +KA+ + ++
Sbjct: 2003 QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2062
Query: 462 SKTRSLQQGPDGLRKQHQSDVEALKRELQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQ 521
+ + Q + Q + + EA +R + E Q E RQ EE E L++
Sbjct: 2063 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER-LKQSA 2121
Query: 522 QEGQELLRHNQELHGRLSEEIDQLRGFIASQGMGNGCGRSNERSSCELEVLLRVKENELQ 581
+E + Q +L +E +Q A R + + E+E + E L+
Sbjct: 2122 EEQAQARAQAQAAAEKLRKEAEQEAARRAQ--AEQAALRQKQAADAEMEKHKKFAEQTLR 2179
Query: 582 ---YLKKEVQCLRDELQMMQKDKRFTSGKYQDVYVELSHIKTRSEREIEQLKEHLRLAMA 638
+++E+ LR +L+ K + Q + E T + R+ Q++E L
Sbjct: 2180 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE----ATEAARQRSQVEEELFSVRV 2235
Query: 639 ALQEKESMR 647
++E ++
Sbjct: 2236 QMEELSKLK 2244
Score = 35.8 bits (81), Expect = 0.13
Identities = 52/201 (25%), Positives = 82/201 (40%), Gaps = 48/201 (23%)
Query: 353 EALEKEVQALRAQLE-AWRLQGEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQQ 411
+ +E+E Q L A +E A R Q EA + R QE+ L ++E +Q
Sbjct: 2539 QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE----------------LQQLEQQRRQ 2582
Query: 412 VMEELQRHHER---ELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQ 468
E L ++R +LQ L+++ LA TAS + A K L R
Sbjct: 2583 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK---------TLPNGRDAL 2633
Query: 469 QGP----------DGLRKQHQSDVEALK-RELQVLSEQYSQKCLE----IGALMRQAEER 513
GP DGLR++ V A + +E +LS + Q+ + + L R+ + R
Sbjct: 2634 DGPAAEAEPEHSFDGLRRK----VSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVR 2689
Query: 514 EHTLRRCQQEGQELLRHNQEL 534
+ R G L N++L
Sbjct: 2690 HYLQGRSSIAGLLLKATNEKL 2710
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 63.5 bits (153), Expect = 6e-10
Identities = 107/484 (22%), Positives = 196/484 (40%), Gaps = 44/484 (9%)
Query: 207 EQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPARTPD-----RLAKQEE 261
+QR EV+ R Q++ EL L Q+S + AR + RL +EE
Sbjct: 1398 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1457
Query: 262 LE--RDLAQRSEERRKWFE----ATDSRTPEVPA----GEGPRRGLGAPLTEDQQNRLSE 311
+ R + +E +R E A +R E A + L + ++ Q +
Sbjct: 1458 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1517
Query: 312 EIEKKWQELEKLPLRENKRVPLTAL----LNQSRGERRGPPSDGHEA------LEKEVQA 361
E+E + + K+ L AL L ERR ++ A LE ++
Sbjct: 1518 EVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1577
Query: 362 LRAQLEAWRLQ-GEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQQVMEELQRHH 420
A+L++ R E RS ++ H+ + +EA R A+ ++ ++ EE +R
Sbjct: 1578 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR--AQQQAEAERAREEAEREL 1635
Query: 421 ER-ELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQQGPDGLRKQHQ 479
ER +L+ + + L AEE A S +A + +EE RE + ++ R+ +
Sbjct: 1636 ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1695
Query: 480 SDVEALKRELQVLSEQ---YSQKCLEIGALMRQAEER----EHTLRRCQQEGQELLRHNQ 532
++E ++ + ++Q Q+ + + A Q E++ E L R Q+E + Q
Sbjct: 1696 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ 1755
Query: 533 ELHGRLSEEIDQLRGFIASQGMGNGCGRS-NERSSCELEV---LLRVKENELQYLKKEVQ 588
EL L++ ++ +AS+ RS +E+S LE R E L+ +
Sbjct: 1756 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1815
Query: 589 CLRDELQMMQKDKRFTSGKYQDVYVELSHIKTRSEREIEQLKEHLRLAMAALQEKESMRN 648
+ + Q+ ++D + + V E K + E +LK +A+ + +
Sbjct: 1816 EAKRQRQLAEEDAARQRAEAERVLAE----KLAAIGEATRLKTEAEIALKEKEAENERLR 1871
Query: 649 SLAE 652
LAE
Sbjct: 1872 RLAE 1875
Score = 60.8 bits (146), Expect = 4e-09
Identities = 108/484 (22%), Positives = 198/484 (40%), Gaps = 67/484 (13%)
Query: 206 GEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPARTPDRLAKQEELERD 265
G Q G + R G R + +R +L QA + R ++L +Q R+
Sbjct: 1159 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE 1218
Query: 266 LAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAPLTEDQQNR--------LSEEIEKKW 317
A + W + R ++ A PL + Q R L EEIE+
Sbjct: 1219 SA---DPLGAWLQDARRRQEQIQA---------MPLADSQAVREQLRQEQALLEEIERHG 1266
Query: 318 QELE------KLPLRENKRVPLTALLNQSRGERRGPPS------DGHEALEKEVQALRAQ 365
+++E K + K L + +++ E P+ G E++ +E LR
Sbjct: 1267 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1326
Query: 366 L-EAWRLQGE----APQSALRSQEDGHIPPGYISQEACERS-LAEMESSHQQVMEELQRH 419
E L + ++ R +E+ + Q A ER LAE+E++ ++ + + H
Sbjct: 1327 YSELTTLTSQYIKFISETLRRMEEEERLAE---QQRAEERERLAEVEAALEKQRQLAEAH 1383
Query: 420 H------ERELQRLQQ--EKEWLLAEETAATASAIEAMKKAYQEELSR-------ELSKT 464
ERE + LQQ ++E + EE A A + K++ QEEL + E+
Sbjct: 1384 AQAKAQAEREAKELQQRMQEEVVRREEAAVDA---QQQKRSIQEELQQLRQSSEAEIQAK 1440
Query: 465 RSLQQGPDGLRKQHQSDVEALKRELQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQQEG 524
+ + R + + ++ ++ +L+ Q E+ AL +AEE E R+ Q+E
Sbjct: 1441 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1500
Query: 525 QELLRHNQELHGRLSEEIDQLRGFIASQGMGNGCGRSNERSSCELEVL-LRVKENELQYL 583
+ L R Q+ R + +L + ++ R +R+ LE L L+ +E E +
Sbjct: 1501 ERLRRQVQDESQRKRQAEVELASRVKAEA---EAAREKQRALQALEELRLQAEEAERRLR 1557
Query: 584 KKEVQCLRDELQMMQKDKRFTSGKYQDVYVELSHIKTRSEREIEQLKEHLRLAMAALQEK 643
+ EV+ R ++ +R + Q + + ER +++ EH +A+A L+E+
Sbjct: 1558 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE--EH--VAVAQLREE 1613
Query: 644 ESMR 647
R
Sbjct: 1614 AERR 1617
Score = 59.7 bits (143), Expect = 8e-09
Identities = 80/345 (23%), Positives = 137/345 (39%), Gaps = 50/345 (14%)
Query: 234 ELSPLTQASPQRARTPARTPDRLAKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEGP 293
E + Q + + AR + ++ E DLAQ+ K + E
Sbjct: 2273 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT----- 2327
Query: 294 RRGLGAPLTEDQQNRLSEEIEKKWQELEKLPLRENKRVPLTALLNQSRGERRGPPSDGHE 353
R A L + Q+ E+ + L+E+K L +++G +R ++
Sbjct: 2328 RLKAEAELLQQQKELAQEQARR---------LQEDKEQMAQQLAEETQGFQRTLEAERQR 2378
Query: 354 ALEKEVQALRAQL---EAWRLQGEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQ 410
LE +A R +L E R Q A + A R ++ I ++ LA E
Sbjct: 2379 QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE----EIGEKLHRTELATQEKVTL 2434
Query: 411 QVMEELQRHH---------------ERELQRLQQEKEWL-LAEETAATASA------IEA 448
E+QR ERE ++LQQE + L L E T +A
Sbjct: 2435 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2494
Query: 449 MKKAYQEELSRELSKTRSLQQGPDGLRKQHQSDV---EALKRELQVLSEQYSQKCLEIGA 505
+++++ E L + R ++Q L + Q +V + L+ E Q +Q Q+ + A
Sbjct: 2495 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2554
Query: 506 LMRQAEEREHT----LRRCQQEGQELLRHNQELHGRLSEEIDQLR 546
M +A R+H +RR Q+E Q+L + ++ L+EE +LR
Sbjct: 2555 SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2599
Score = 53.9 bits (128), Expect = 5e-07
Identities = 110/489 (22%), Positives = 192/489 (39%), Gaps = 67/489 (13%)
Query: 197 STQKGPLKAGEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPARTPDRL 256
S Q+ +AG R +E +R + +RQ E A+ QRA ++L
Sbjct: 1789 SKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE-----DAARQRAEAERVLAEKL 1843
Query: 257 AKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEG-PRRGLGAPLTEDQQNRLSEEIEK 315
A E R L +E K EA + R + E RR L E+Q + +IE+
Sbjct: 1844 AAIGEATR-LKTEAEIALKEKEAENERLRRLAEDEAFQRRRL-----EEQAAQHKADIEE 1897
Query: 316 KWQELEKLPLRENKRVPLTALLNQSRGERRGPPSDGHEALEKEVQALRA----------- 364
+ +L K E +R L+ + +RR +E+E+ AL+A
Sbjct: 1898 RLAQLRKASDSELERQK--GLVEDTLRQRR--------QVEEEILALKASFEKAAAGKAE 1947
Query: 365 -QLEAWRLQGEAPQSALRSQEDGHIPPGYISQEACE-------------RSLAEMESSHQ 410
+LE R++ A + LRS+E + Q A E +SLA E + +
Sbjct: 1948 LELELGRIRSNA-EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 2006
Query: 411 Q---VMEELQR------HHERELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSREL 461
Q +EE++R R +R +QE L A ++A +KA+ + ++
Sbjct: 2007 QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2066
Query: 462 SKTRSLQQGPDGLRKQHQSDVEALKRELQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQ 521
+ + Q + Q + + EA +R + E Q E RQ EE E L++
Sbjct: 2067 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER-LKQSA 2125
Query: 522 QEGQELLRHNQELHGRLSEEIDQLRGFIASQGMGNGCGRSNERSSCELEVLLRVKENELQ 581
+E + Q +L +E +Q A R + + E+E + E L+
Sbjct: 2126 EEQAQARAQAQAAAEKLRKEAEQEAARRAQ--AEQAALRQKQAADAEMEKHKKFAEQTLR 2183
Query: 582 ---YLKKEVQCLRDELQMMQKDKRFTSGKYQDVYVELSHIKTRSEREIEQLKEHLRLAMA 638
+++E+ LR +L+ K + Q + E T + R+ Q++E L
Sbjct: 2184 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE----ATEAARQRSQVEEELFSVRV 2239
Query: 639 ALQEKESMR 647
++E ++
Sbjct: 2240 QMEELSKLK 2248
Score = 35.8 bits (81), Expect = 0.13
Identities = 52/201 (25%), Positives = 82/201 (40%), Gaps = 48/201 (23%)
Query: 353 EALEKEVQALRAQLE-AWRLQGEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQQ 411
+ +E+E Q L A +E A R Q EA + R QE+ L ++E +Q
Sbjct: 2543 QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE----------------LQQLEQQRRQ 2586
Query: 412 VMEELQRHHER---ELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQ 468
E L ++R +LQ L+++ LA TAS + A K L R
Sbjct: 2587 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK---------TLPNGRDAL 2637
Query: 469 QGP----------DGLRKQHQSDVEALK-RELQVLSEQYSQKCLE----IGALMRQAEER 513
GP DGLR++ V A + +E +LS + Q+ + + L R+ + R
Sbjct: 2638 DGPAAEAEPEHSFDGLRRK----VSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVR 2693
Query: 514 EHTLRRCQQEGQELLRHNQEL 534
+ R G L N++L
Sbjct: 2694 HYLQGRSSIAGLLLKATNEKL 2714
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 63.5 bits (153), Expect = 6e-10
Identities = 107/484 (22%), Positives = 196/484 (40%), Gaps = 44/484 (9%)
Query: 207 EQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPARTPD-----RLAKQEE 261
+QR EV+ R Q++ EL L Q+S + AR + RL +EE
Sbjct: 1394 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1453
Query: 262 LE--RDLAQRSEERRKWFE----ATDSRTPEVPA----GEGPRRGLGAPLTEDQQNRLSE 311
+ R + +E +R E A +R E A + L + ++ Q +
Sbjct: 1454 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1513
Query: 312 EIEKKWQELEKLPLRENKRVPLTAL----LNQSRGERRGPPSDGHEA------LEKEVQA 361
E+E + + K+ L AL L ERR ++ A LE ++
Sbjct: 1514 EVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1573
Query: 362 LRAQLEAWRLQ-GEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQQVMEELQRHH 420
A+L++ R E RS ++ H+ + +EA R A+ ++ ++ EE +R
Sbjct: 1574 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR--AQQQAEAERAREEAEREL 1631
Query: 421 ER-ELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQQGPDGLRKQHQ 479
ER +L+ + + L AEE A S +A + +EE RE + ++ R+ +
Sbjct: 1632 ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1691
Query: 480 SDVEALKRELQVLSEQ---YSQKCLEIGALMRQAEER----EHTLRRCQQEGQELLRHNQ 532
++E ++ + ++Q Q+ + + A Q E++ E L R Q+E + Q
Sbjct: 1692 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ 1751
Query: 533 ELHGRLSEEIDQLRGFIASQGMGNGCGRS-NERSSCELEV---LLRVKENELQYLKKEVQ 588
EL L++ ++ +AS+ RS +E+S LE R E L+ +
Sbjct: 1752 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1811
Query: 589 CLRDELQMMQKDKRFTSGKYQDVYVELSHIKTRSEREIEQLKEHLRLAMAALQEKESMRN 648
+ + Q+ ++D + + V E K + E +LK +A+ + +
Sbjct: 1812 EAKRQRQLAEEDAARQRAEAERVLAE----KLAAIGEATRLKTEAEIALKEKEAENERLR 1867
Query: 649 SLAE 652
LAE
Sbjct: 1868 RLAE 1871
Score = 60.8 bits (146), Expect = 4e-09
Identities = 108/484 (22%), Positives = 198/484 (40%), Gaps = 67/484 (13%)
Query: 206 GEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPARTPDRLAKQEELERD 265
G Q G + R G R + +R +L QA + R ++L +Q R+
Sbjct: 1155 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE 1214
Query: 266 LAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAPLTEDQQNR--------LSEEIEKKW 317
A + W + R ++ A PL + Q R L EEIE+
Sbjct: 1215 SA---DPLGAWLQDARRRQEQIQA---------MPLADSQAVREQLRQEQALLEEIERHG 1262
Query: 318 QELE------KLPLRENKRVPLTALLNQSRGERRGPPS------DGHEALEKEVQALRAQ 365
+++E K + K L + +++ E P+ G E++ +E LR
Sbjct: 1263 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1322
Query: 366 L-EAWRLQGE----APQSALRSQEDGHIPPGYISQEACERS-LAEMESSHQQVMEELQRH 419
E L + ++ R +E+ + Q A ER LAE+E++ ++ + + H
Sbjct: 1323 YSELTTLTSQYIKFISETLRRMEEEERLAE---QQRAEERERLAEVEAALEKQRQLAEAH 1379
Query: 420 H------ERELQRLQQ--EKEWLLAEETAATASAIEAMKKAYQEELSR-------ELSKT 464
ERE + LQQ ++E + EE A A + K++ QEEL + E+
Sbjct: 1380 AQAKAQAEREAKELQQRMQEEVVRREEAAVDA---QQQKRSIQEELQQLRQSSEAEIQAK 1436
Query: 465 RSLQQGPDGLRKQHQSDVEALKRELQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQQEG 524
+ + R + + ++ ++ +L+ Q E+ AL +AEE E R+ Q+E
Sbjct: 1437 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1496
Query: 525 QELLRHNQELHGRLSEEIDQLRGFIASQGMGNGCGRSNERSSCELEVL-LRVKENELQYL 583
+ L R Q+ R + +L + ++ R +R+ LE L L+ +E E +
Sbjct: 1497 ERLRRQVQDESQRKRQAEVELASRVKAEA---EAAREKQRALQALEELRLQAEEAERRLR 1553
Query: 584 KKEVQCLRDELQMMQKDKRFTSGKYQDVYVELSHIKTRSEREIEQLKEHLRLAMAALQEK 643
+ EV+ R ++ +R + Q + + ER +++ EH +A+A L+E+
Sbjct: 1554 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE--EH--VAVAQLREE 1609
Query: 644 ESMR 647
R
Sbjct: 1610 AERR 1613
Score = 59.7 bits (143), Expect = 8e-09
Identities = 80/345 (23%), Positives = 137/345 (39%), Gaps = 50/345 (14%)
Query: 234 ELSPLTQASPQRARTPARTPDRLAKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEGP 293
E + Q + + AR + ++ E DLAQ+ K + E
Sbjct: 2269 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT----- 2323
Query: 294 RRGLGAPLTEDQQNRLSEEIEKKWQELEKLPLRENKRVPLTALLNQSRGERRGPPSDGHE 353
R A L + Q+ E+ + L+E+K L +++G +R ++
Sbjct: 2324 RLKAEAELLQQQKELAQEQARR---------LQEDKEQMAQQLAEETQGFQRTLEAERQR 2374
Query: 354 ALEKEVQALRAQL---EAWRLQGEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQ 410
LE +A R +L E R Q A + A R ++ I ++ LA E
Sbjct: 2375 QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE----EIGEKLHRTELATQEKVTL 2430
Query: 411 QVMEELQRHH---------------ERELQRLQQEKEWL-LAEETAATASA------IEA 448
E+QR ERE ++LQQE + L L E T +A
Sbjct: 2431 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2490
Query: 449 MKKAYQEELSRELSKTRSLQQGPDGLRKQHQSDV---EALKRELQVLSEQYSQKCLEIGA 505
+++++ E L + R ++Q L + Q +V + L+ E Q +Q Q+ + A
Sbjct: 2491 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2550
Query: 506 LMRQAEEREHT----LRRCQQEGQELLRHNQELHGRLSEEIDQLR 546
M +A R+H +RR Q+E Q+L + ++ L+EE +LR
Sbjct: 2551 SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2595
Score = 53.9 bits (128), Expect = 5e-07
Identities = 110/489 (22%), Positives = 192/489 (39%), Gaps = 67/489 (13%)
Query: 197 STQKGPLKAGEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPARTPDRL 256
S Q+ +AG R +E +R + +RQ E A+ QRA ++L
Sbjct: 1785 SKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE-----DAARQRAEAERVLAEKL 1839
Query: 257 AKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEG-PRRGLGAPLTEDQQNRLSEEIEK 315
A E R L +E K EA + R + E RR L E+Q + +IE+
Sbjct: 1840 AAIGEATR-LKTEAEIALKEKEAENERLRRLAEDEAFQRRRL-----EEQAAQHKADIEE 1893
Query: 316 KWQELEKLPLRENKRVPLTALLNQSRGERRGPPSDGHEALEKEVQALRA----------- 364
+ +L K E +R L+ + +RR +E+E+ AL+A
Sbjct: 1894 RLAQLRKASDSELERQK--GLVEDTLRQRR--------QVEEEILALKASFEKAAAGKAE 1943
Query: 365 -QLEAWRLQGEAPQSALRSQEDGHIPPGYISQEACE-------------RSLAEMESSHQ 410
+LE R++ A + LRS+E + Q A E +SLA E + +
Sbjct: 1944 LELELGRIRSNA-EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 2002
Query: 411 Q---VMEELQR------HHERELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSREL 461
Q +EE++R R +R +QE L A ++A +KA+ + ++
Sbjct: 2003 QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2062
Query: 462 SKTRSLQQGPDGLRKQHQSDVEALKRELQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQ 521
+ + Q + Q + + EA +R + E Q E RQ EE E L++
Sbjct: 2063 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER-LKQSA 2121
Query: 522 QEGQELLRHNQELHGRLSEEIDQLRGFIASQGMGNGCGRSNERSSCELEVLLRVKENELQ 581
+E + Q +L +E +Q A R + + E+E + E L+
Sbjct: 2122 EEQAQARAQAQAAAEKLRKEAEQEAARRAQ--AEQAALRQKQAADAEMEKHKKFAEQTLR 2179
Query: 582 ---YLKKEVQCLRDELQMMQKDKRFTSGKYQDVYVELSHIKTRSEREIEQLKEHLRLAMA 638
+++E+ LR +L+ K + Q + E T + R+ Q++E L
Sbjct: 2180 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE----ATEAARQRSQVEEELFSVRV 2235
Query: 639 ALQEKESMR 647
++E ++
Sbjct: 2236 QMEELSKLK 2244
Score = 35.8 bits (81), Expect = 0.13
Identities = 52/201 (25%), Positives = 82/201 (40%), Gaps = 48/201 (23%)
Query: 353 EALEKEVQALRAQLE-AWRLQGEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQQ 411
+ +E+E Q L A +E A R Q EA + R QE+ L ++E +Q
Sbjct: 2539 QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE----------------LQQLEQQRRQ 2582
Query: 412 VMEELQRHHER---ELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQ 468
E L ++R +LQ L+++ LA TAS + A K L R
Sbjct: 2583 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK---------TLPNGRDAL 2633
Query: 469 QGP----------DGLRKQHQSDVEALK-RELQVLSEQYSQKCLE----IGALMRQAEER 513
GP DGLR++ V A + +E +LS + Q+ + + L R+ + R
Sbjct: 2634 DGPAAEAEPEHSFDGLRRK----VSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVR 2689
Query: 514 EHTLRRCQQEGQELLRHNQEL 534
+ R G L N++L
Sbjct: 2690 HYLQGRSSIAGLLLKATNEKL 2710
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 63.5 bits (153), Expect = 6e-10
Identities = 107/484 (22%), Positives = 196/484 (40%), Gaps = 44/484 (9%)
Query: 207 EQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPARTPD-----RLAKQEE 261
+QR EV+ R Q++ EL L Q+S + AR + RL +EE
Sbjct: 1362 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1421
Query: 262 LE--RDLAQRSEERRKWFE----ATDSRTPEVPA----GEGPRRGLGAPLTEDQQNRLSE 311
+ R + +E +R E A +R E A + L + ++ Q +
Sbjct: 1422 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1481
Query: 312 EIEKKWQELEKLPLRENKRVPLTAL----LNQSRGERRGPPSDGHEA------LEKEVQA 361
E+E + + K+ L AL L ERR ++ A LE ++
Sbjct: 1482 EVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1541
Query: 362 LRAQLEAWRLQ-GEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQQVMEELQRHH 420
A+L++ R E RS ++ H+ + +EA R A+ ++ ++ EE +R
Sbjct: 1542 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR--AQQQAEAERAREEAEREL 1599
Query: 421 ER-ELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQQGPDGLRKQHQ 479
ER +L+ + + L AEE A S +A + +EE RE + ++ R+ +
Sbjct: 1600 ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1659
Query: 480 SDVEALKRELQVLSEQ---YSQKCLEIGALMRQAEER----EHTLRRCQQEGQELLRHNQ 532
++E ++ + ++Q Q+ + + A Q E++ E L R Q+E + Q
Sbjct: 1660 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ 1719
Query: 533 ELHGRLSEEIDQLRGFIASQGMGNGCGRS-NERSSCELEV---LLRVKENELQYLKKEVQ 588
EL L++ ++ +AS+ RS +E+S LE R E L+ +
Sbjct: 1720 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1779
Query: 589 CLRDELQMMQKDKRFTSGKYQDVYVELSHIKTRSEREIEQLKEHLRLAMAALQEKESMRN 648
+ + Q+ ++D + + V E K + E +LK +A+ + +
Sbjct: 1780 EAKRQRQLAEEDAARQRAEAERVLAE----KLAAIGEATRLKTEAEIALKEKEAENERLR 1835
Query: 649 SLAE 652
LAE
Sbjct: 1836 RLAE 1839
Score = 60.8 bits (146), Expect = 4e-09
Identities = 108/484 (22%), Positives = 198/484 (40%), Gaps = 67/484 (13%)
Query: 206 GEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPARTPDRLAKQEELERD 265
G Q G + R G R + +R +L QA + R ++L +Q R+
Sbjct: 1123 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE 1182
Query: 266 LAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAPLTEDQQNR--------LSEEIEKKW 317
A + W + R ++ A PL + Q R L EEIE+
Sbjct: 1183 SA---DPLGAWLQDARRRQEQIQA---------MPLADSQAVREQLRQEQALLEEIERHG 1230
Query: 318 QELE------KLPLRENKRVPLTALLNQSRGERRGPPS------DGHEALEKEVQALRAQ 365
+++E K + K L + +++ E P+ G E++ +E LR
Sbjct: 1231 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1290
Query: 366 L-EAWRLQGE----APQSALRSQEDGHIPPGYISQEACERS-LAEMESSHQQVMEELQRH 419
E L + ++ R +E+ + Q A ER LAE+E++ ++ + + H
Sbjct: 1291 YSELTTLTSQYIKFISETLRRMEEEERLAE---QQRAEERERLAEVEAALEKQRQLAEAH 1347
Query: 420 H------ERELQRLQQ--EKEWLLAEETAATASAIEAMKKAYQEELSR-------ELSKT 464
ERE + LQQ ++E + EE A A + K++ QEEL + E+
Sbjct: 1348 AQAKAQAEREAKELQQRMQEEVVRREEAAVDA---QQQKRSIQEELQQLRQSSEAEIQAK 1404
Query: 465 RSLQQGPDGLRKQHQSDVEALKRELQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQQEG 524
+ + R + + ++ ++ +L+ Q E+ AL +AEE E R+ Q+E
Sbjct: 1405 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1464
Query: 525 QELLRHNQELHGRLSEEIDQLRGFIASQGMGNGCGRSNERSSCELEVL-LRVKENELQYL 583
+ L R Q+ R + +L + ++ R +R+ LE L L+ +E E +
Sbjct: 1465 ERLRRQVQDESQRKRQAEVELASRVKAEA---EAAREKQRALQALEELRLQAEEAERRLR 1521
Query: 584 KKEVQCLRDELQMMQKDKRFTSGKYQDVYVELSHIKTRSEREIEQLKEHLRLAMAALQEK 643
+ EV+ R ++ +R + Q + + ER +++ EH +A+A L+E+
Sbjct: 1522 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE--EH--VAVAQLREE 1577
Query: 644 ESMR 647
R
Sbjct: 1578 AERR 1581
Score = 59.7 bits (143), Expect = 8e-09
Identities = 80/345 (23%), Positives = 137/345 (39%), Gaps = 50/345 (14%)
Query: 234 ELSPLTQASPQRARTPARTPDRLAKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEGP 293
E + Q + + AR + ++ E DLAQ+ K + E
Sbjct: 2237 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT----- 2291
Query: 294 RRGLGAPLTEDQQNRLSEEIEKKWQELEKLPLRENKRVPLTALLNQSRGERRGPPSDGHE 353
R A L + Q+ E+ + L+E+K L +++G +R ++
Sbjct: 2292 RLKAEAELLQQQKELAQEQARR---------LQEDKEQMAQQLAEETQGFQRTLEAERQR 2342
Query: 354 ALEKEVQALRAQL---EAWRLQGEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQ 410
LE +A R +L E R Q A + A R ++ I ++ LA E
Sbjct: 2343 QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE----EIGEKLHRTELATQEKVTL 2398
Query: 411 QVMEELQRHH---------------ERELQRLQQEKEWL-LAEETAATASA------IEA 448
E+QR ERE ++LQQE + L L E T +A
Sbjct: 2399 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2458
Query: 449 MKKAYQEELSRELSKTRSLQQGPDGLRKQHQSDV---EALKRELQVLSEQYSQKCLEIGA 505
+++++ E L + R ++Q L + Q +V + L+ E Q +Q Q+ + A
Sbjct: 2459 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2518
Query: 506 LMRQAEEREHT----LRRCQQEGQELLRHNQELHGRLSEEIDQLR 546
M +A R+H +RR Q+E Q+L + ++ L+EE +LR
Sbjct: 2519 SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2563
Score = 53.9 bits (128), Expect = 5e-07
Identities = 110/489 (22%), Positives = 192/489 (39%), Gaps = 67/489 (13%)
Query: 197 STQKGPLKAGEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPARTPDRL 256
S Q+ +AG R +E +R + +RQ E A+ QRA ++L
Sbjct: 1753 SKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE-----DAARQRAEAERVLAEKL 1807
Query: 257 AKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEG-PRRGLGAPLTEDQQNRLSEEIEK 315
A E R L +E K EA + R + E RR L E+Q + +IE+
Sbjct: 1808 AAIGEATR-LKTEAEIALKEKEAENERLRRLAEDEAFQRRRL-----EEQAAQHKADIEE 1861
Query: 316 KWQELEKLPLRENKRVPLTALLNQSRGERRGPPSDGHEALEKEVQALRA----------- 364
+ +L K E +R L+ + +RR +E+E+ AL+A
Sbjct: 1862 RLAQLRKASDSELERQK--GLVEDTLRQRR--------QVEEEILALKASFEKAAAGKAE 1911
Query: 365 -QLEAWRLQGEAPQSALRSQEDGHIPPGYISQEACE-------------RSLAEMESSHQ 410
+LE R++ A + LRS+E + Q A E +SLA E + +
Sbjct: 1912 LELELGRIRSNA-EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 1970
Query: 411 Q---VMEELQR------HHERELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSREL 461
Q +EE++R R +R +QE L A ++A +KA+ + ++
Sbjct: 1971 QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2030
Query: 462 SKTRSLQQGPDGLRKQHQSDVEALKRELQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQ 521
+ + Q + Q + + EA +R + E Q E RQ EE E L++
Sbjct: 2031 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER-LKQSA 2089
Query: 522 QEGQELLRHNQELHGRLSEEIDQLRGFIASQGMGNGCGRSNERSSCELEVLLRVKENELQ 581
+E + Q +L +E +Q A R + + E+E + E L+
Sbjct: 2090 EEQAQARAQAQAAAEKLRKEAEQEAARRAQ--AEQAALRQKQAADAEMEKHKKFAEQTLR 2147
Query: 582 ---YLKKEVQCLRDELQMMQKDKRFTSGKYQDVYVELSHIKTRSEREIEQLKEHLRLAMA 638
+++E+ LR +L+ K + Q + E T + R+ Q++E L
Sbjct: 2148 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE----ATEAARQRSQVEEELFSVRV 2203
Query: 639 ALQEKESMR 647
++E ++
Sbjct: 2204 QMEELSKLK 2212
Score = 35.8 bits (81), Expect = 0.13
Identities = 52/201 (25%), Positives = 82/201 (40%), Gaps = 48/201 (23%)
Query: 353 EALEKEVQALRAQLE-AWRLQGEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQQ 411
+ +E+E Q L A +E A R Q EA + R QE+ L ++E +Q
Sbjct: 2507 QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE----------------LQQLEQQRRQ 2550
Query: 412 VMEELQRHHER---ELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQ 468
E L ++R +LQ L+++ LA TAS + A K L R
Sbjct: 2551 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK---------TLPNGRDAL 2601
Query: 469 QGP----------DGLRKQHQSDVEALK-RELQVLSEQYSQKCLE----IGALMRQAEER 513
GP DGLR++ V A + +E +LS + Q+ + + L R+ + R
Sbjct: 2602 DGPAAEAEPEHSFDGLRRK----VSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVR 2657
Query: 514 EHTLRRCQQEGQELLRHNQEL 534
+ R G L N++L
Sbjct: 2658 HYLQGRSSIAGLLLKATNEKL 2678
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 63.5 bits (153), Expect = 6e-10
Identities = 107/484 (22%), Positives = 196/484 (40%), Gaps = 44/484 (9%)
Query: 207 EQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPARTPD-----RLAKQEE 261
+QR EV+ R Q++ EL L Q+S + AR + RL +EE
Sbjct: 1531 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1590
Query: 262 LE--RDLAQRSEERRKWFE----ATDSRTPEVPA----GEGPRRGLGAPLTEDQQNRLSE 311
+ R + +E +R E A +R E A + L + ++ Q +
Sbjct: 1591 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1650
Query: 312 EIEKKWQELEKLPLRENKRVPLTAL----LNQSRGERRGPPSDGHEA------LEKEVQA 361
E+E + + K+ L AL L ERR ++ A LE ++
Sbjct: 1651 EVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1710
Query: 362 LRAQLEAWRLQ-GEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQQVMEELQRHH 420
A+L++ R E RS ++ H+ + +EA R A+ ++ ++ EE +R
Sbjct: 1711 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR--AQQQAEAERAREEAEREL 1768
Query: 421 ER-ELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQQGPDGLRKQHQ 479
ER +L+ + + L AEE A S +A + +EE RE + ++ R+ +
Sbjct: 1769 ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1828
Query: 480 SDVEALKRELQVLSEQ---YSQKCLEIGALMRQAEER----EHTLRRCQQEGQELLRHNQ 532
++E ++ + ++Q Q+ + + A Q E++ E L R Q+E + Q
Sbjct: 1829 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ 1888
Query: 533 ELHGRLSEEIDQLRGFIASQGMGNGCGRS-NERSSCELEV---LLRVKENELQYLKKEVQ 588
EL L++ ++ +AS+ RS +E+S LE R E L+ +
Sbjct: 1889 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1948
Query: 589 CLRDELQMMQKDKRFTSGKYQDVYVELSHIKTRSEREIEQLKEHLRLAMAALQEKESMRN 648
+ + Q+ ++D + + V E K + E +LK +A+ + +
Sbjct: 1949 EAKRQRQLAEEDAARQRAEAERVLAE----KLAAIGEATRLKTEAEIALKEKEAENERLR 2004
Query: 649 SLAE 652
LAE
Sbjct: 2005 RLAE 2008
Score = 60.8 bits (146), Expect = 4e-09
Identities = 108/484 (22%), Positives = 198/484 (40%), Gaps = 67/484 (13%)
Query: 206 GEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPARTPDRLAKQEELERD 265
G Q G + R G R + +R +L QA + R ++L +Q R+
Sbjct: 1292 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE 1351
Query: 266 LAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAPLTEDQQNR--------LSEEIEKKW 317
A + W + R ++ A PL + Q R L EEIE+
Sbjct: 1352 SA---DPLGAWLQDARRRQEQIQA---------MPLADSQAVREQLRQEQALLEEIERHG 1399
Query: 318 QELE------KLPLRENKRVPLTALLNQSRGERRGPPS------DGHEALEKEVQALRAQ 365
+++E K + K L + +++ E P+ G E++ +E LR
Sbjct: 1400 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1459
Query: 366 L-EAWRLQGE----APQSALRSQEDGHIPPGYISQEACERS-LAEMESSHQQVMEELQRH 419
E L + ++ R +E+ + Q A ER LAE+E++ ++ + + H
Sbjct: 1460 YSELTTLTSQYIKFISETLRRMEEEERLAE---QQRAEERERLAEVEAALEKQRQLAEAH 1516
Query: 420 H------ERELQRLQQ--EKEWLLAEETAATASAIEAMKKAYQEELSR-------ELSKT 464
ERE + LQQ ++E + EE A A + K++ QEEL + E+
Sbjct: 1517 AQAKAQAEREAKELQQRMQEEVVRREEAAVDA---QQQKRSIQEELQQLRQSSEAEIQAK 1573
Query: 465 RSLQQGPDGLRKQHQSDVEALKRELQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQQEG 524
+ + R + + ++ ++ +L+ Q E+ AL +AEE E R+ Q+E
Sbjct: 1574 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1633
Query: 525 QELLRHNQELHGRLSEEIDQLRGFIASQGMGNGCGRSNERSSCELEVL-LRVKENELQYL 583
+ L R Q+ R + +L + ++ R +R+ LE L L+ +E E +
Sbjct: 1634 ERLRRQVQDESQRKRQAEVELASRVKAEA---EAAREKQRALQALEELRLQAEEAERRLR 1690
Query: 584 KKEVQCLRDELQMMQKDKRFTSGKYQDVYVELSHIKTRSEREIEQLKEHLRLAMAALQEK 643
+ EV+ R ++ +R + Q + + ER +++ EH +A+A L+E+
Sbjct: 1691 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE--EH--VAVAQLREE 1746
Query: 644 ESMR 647
R
Sbjct: 1747 AERR 1750
Score = 59.7 bits (143), Expect = 8e-09
Identities = 80/345 (23%), Positives = 137/345 (39%), Gaps = 50/345 (14%)
Query: 234 ELSPLTQASPQRARTPARTPDRLAKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEGP 293
E + Q + + AR + ++ E DLAQ+ K + E
Sbjct: 2406 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT----- 2460
Query: 294 RRGLGAPLTEDQQNRLSEEIEKKWQELEKLPLRENKRVPLTALLNQSRGERRGPPSDGHE 353
R A L + Q+ E+ + L+E+K L +++G +R ++
Sbjct: 2461 RLKAEAELLQQQKELAQEQARR---------LQEDKEQMAQQLAEETQGFQRTLEAERQR 2511
Query: 354 ALEKEVQALRAQL---EAWRLQGEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQ 410
LE +A R +L E R Q A + A R ++ I ++ LA E
Sbjct: 2512 QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE----EIGEKLHRTELATQEKVTL 2567
Query: 411 QVMEELQRHH---------------ERELQRLQQEKEWL-LAEETAATASA------IEA 448
E+QR ERE ++LQQE + L L E T +A
Sbjct: 2568 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2627
Query: 449 MKKAYQEELSRELSKTRSLQQGPDGLRKQHQSDV---EALKRELQVLSEQYSQKCLEIGA 505
+++++ E L + R ++Q L + Q +V + L+ E Q +Q Q+ + A
Sbjct: 2628 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2687
Query: 506 LMRQAEEREHT----LRRCQQEGQELLRHNQELHGRLSEEIDQLR 546
M +A R+H +RR Q+E Q+L + ++ L+EE +LR
Sbjct: 2688 SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2732
Score = 53.9 bits (128), Expect = 5e-07
Identities = 110/489 (22%), Positives = 192/489 (39%), Gaps = 67/489 (13%)
Query: 197 STQKGPLKAGEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPARTPDRL 256
S Q+ +AG R +E +R + +RQ E A+ QRA ++L
Sbjct: 1922 SKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE-----DAARQRAEAERVLAEKL 1976
Query: 257 AKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEG-PRRGLGAPLTEDQQNRLSEEIEK 315
A E R L +E K EA + R + E RR L E+Q + +IE+
Sbjct: 1977 AAIGEATR-LKTEAEIALKEKEAENERLRRLAEDEAFQRRRL-----EEQAAQHKADIEE 2030
Query: 316 KWQELEKLPLRENKRVPLTALLNQSRGERRGPPSDGHEALEKEVQALRA----------- 364
+ +L K E +R L+ + +RR +E+E+ AL+A
Sbjct: 2031 RLAQLRKASDSELERQK--GLVEDTLRQRR--------QVEEEILALKASFEKAAAGKAE 2080
Query: 365 -QLEAWRLQGEAPQSALRSQEDGHIPPGYISQEACE-------------RSLAEMESSHQ 410
+LE R++ A + LRS+E + Q A E +SLA E + +
Sbjct: 2081 LELELGRIRSNA-EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 2139
Query: 411 Q---VMEELQR------HHERELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSREL 461
Q +EE++R R +R +QE L A ++A +KA+ + ++
Sbjct: 2140 QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2199
Query: 462 SKTRSLQQGPDGLRKQHQSDVEALKRELQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQ 521
+ + Q + Q + + EA +R + E Q E RQ EE E L++
Sbjct: 2200 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER-LKQSA 2258
Query: 522 QEGQELLRHNQELHGRLSEEIDQLRGFIASQGMGNGCGRSNERSSCELEVLLRVKENELQ 581
+E + Q +L +E +Q A R + + E+E + E L+
Sbjct: 2259 EEQAQARAQAQAAAEKLRKEAEQEAARRAQ--AEQAALRQKQAADAEMEKHKKFAEQTLR 2316
Query: 582 ---YLKKEVQCLRDELQMMQKDKRFTSGKYQDVYVELSHIKTRSEREIEQLKEHLRLAMA 638
+++E+ LR +L+ K + Q + E T + R+ Q++E L
Sbjct: 2317 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE----ATEAARQRSQVEEELFSVRV 2372
Query: 639 ALQEKESMR 647
++E ++
Sbjct: 2373 QMEELSKLK 2381
Score = 35.8 bits (81), Expect = 0.13
Identities = 52/201 (25%), Positives = 82/201 (40%), Gaps = 48/201 (23%)
Query: 353 EALEKEVQALRAQLE-AWRLQGEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQQ 411
+ +E+E Q L A +E A R Q EA + R QE+ L ++E +Q
Sbjct: 2676 QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE----------------LQQLEQQRRQ 2719
Query: 412 VMEELQRHHER---ELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQ 468
E L ++R +LQ L+++ LA TAS + A K L R
Sbjct: 2720 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK---------TLPNGRDAL 2770
Query: 469 QGP----------DGLRKQHQSDVEALK-RELQVLSEQYSQKCLE----IGALMRQAEER 513
GP DGLR++ V A + +E +LS + Q+ + + L R+ + R
Sbjct: 2771 DGPAAEAEPEHSFDGLRRK----VSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVR 2826
Query: 514 EHTLRRCQQEGQELLRHNQEL 534
+ R G L N++L
Sbjct: 2827 HYLQGRSSIAGLLLKATNEKL 2847
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 63.5 bits (153), Expect = 6e-10
Identities = 107/484 (22%), Positives = 196/484 (40%), Gaps = 44/484 (9%)
Query: 207 EQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPARTPD-----RLAKQEE 261
+QR EV+ R Q++ EL L Q+S + AR + RL +EE
Sbjct: 1372 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1431
Query: 262 LE--RDLAQRSEERRKWFE----ATDSRTPEVPA----GEGPRRGLGAPLTEDQQNRLSE 311
+ R + +E +R E A +R E A + L + ++ Q +
Sbjct: 1432 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1491
Query: 312 EIEKKWQELEKLPLRENKRVPLTAL----LNQSRGERRGPPSDGHEA------LEKEVQA 361
E+E + + K+ L AL L ERR ++ A LE ++
Sbjct: 1492 EVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1551
Query: 362 LRAQLEAWRLQ-GEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQQVMEELQRHH 420
A+L++ R E RS ++ H+ + +EA R A+ ++ ++ EE +R
Sbjct: 1552 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR--AQQQAEAERAREEAEREL 1609
Query: 421 ER-ELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQQGPDGLRKQHQ 479
ER +L+ + + L AEE A S +A + +EE RE + ++ R+ +
Sbjct: 1610 ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1669
Query: 480 SDVEALKRELQVLSEQ---YSQKCLEIGALMRQAEER----EHTLRRCQQEGQELLRHNQ 532
++E ++ + ++Q Q+ + + A Q E++ E L R Q+E + Q
Sbjct: 1670 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ 1729
Query: 533 ELHGRLSEEIDQLRGFIASQGMGNGCGRS-NERSSCELEV---LLRVKENELQYLKKEVQ 588
EL L++ ++ +AS+ RS +E+S LE R E L+ +
Sbjct: 1730 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1789
Query: 589 CLRDELQMMQKDKRFTSGKYQDVYVELSHIKTRSEREIEQLKEHLRLAMAALQEKESMRN 648
+ + Q+ ++D + + V E K + E +LK +A+ + +
Sbjct: 1790 EAKRQRQLAEEDAARQRAEAERVLAE----KLAAIGEATRLKTEAEIALKEKEAENERLR 1845
Query: 649 SLAE 652
LAE
Sbjct: 1846 RLAE 1849
Score = 60.8 bits (146), Expect = 4e-09
Identities = 108/484 (22%), Positives = 198/484 (40%), Gaps = 67/484 (13%)
Query: 206 GEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPARTPDRLAKQEELERD 265
G Q G + R G R + +R +L QA + R ++L +Q R+
Sbjct: 1133 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE 1192
Query: 266 LAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAPLTEDQQNR--------LSEEIEKKW 317
A + W + R ++ A PL + Q R L EEIE+
Sbjct: 1193 SA---DPLGAWLQDARRRQEQIQA---------MPLADSQAVREQLRQEQALLEEIERHG 1240
Query: 318 QELE------KLPLRENKRVPLTALLNQSRGERRGPPS------DGHEALEKEVQALRAQ 365
+++E K + K L + +++ E P+ G E++ +E LR
Sbjct: 1241 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1300
Query: 366 L-EAWRLQGE----APQSALRSQEDGHIPPGYISQEACERS-LAEMESSHQQVMEELQRH 419
E L + ++ R +E+ + Q A ER LAE+E++ ++ + + H
Sbjct: 1301 YSELTTLTSQYIKFISETLRRMEEEERLAE---QQRAEERERLAEVEAALEKQRQLAEAH 1357
Query: 420 H------ERELQRLQQ--EKEWLLAEETAATASAIEAMKKAYQEELSR-------ELSKT 464
ERE + LQQ ++E + EE A A + K++ QEEL + E+
Sbjct: 1358 AQAKAQAEREAKELQQRMQEEVVRREEAAVDA---QQQKRSIQEELQQLRQSSEAEIQAK 1414
Query: 465 RSLQQGPDGLRKQHQSDVEALKRELQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQQEG 524
+ + R + + ++ ++ +L+ Q E+ AL +AEE E R+ Q+E
Sbjct: 1415 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1474
Query: 525 QELLRHNQELHGRLSEEIDQLRGFIASQGMGNGCGRSNERSSCELEVL-LRVKENELQYL 583
+ L R Q+ R + +L + ++ R +R+ LE L L+ +E E +
Sbjct: 1475 ERLRRQVQDESQRKRQAEVELASRVKAEA---EAAREKQRALQALEELRLQAEEAERRLR 1531
Query: 584 KKEVQCLRDELQMMQKDKRFTSGKYQDVYVELSHIKTRSEREIEQLKEHLRLAMAALQEK 643
+ EV+ R ++ +R + Q + + ER +++ EH +A+A L+E+
Sbjct: 1532 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE--EH--VAVAQLREE 1587
Query: 644 ESMR 647
R
Sbjct: 1588 AERR 1591
Score = 59.7 bits (143), Expect = 8e-09
Identities = 80/345 (23%), Positives = 137/345 (39%), Gaps = 50/345 (14%)
Query: 234 ELSPLTQASPQRARTPARTPDRLAKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEGP 293
E + Q + + AR + ++ E DLAQ+ K + E
Sbjct: 2247 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT----- 2301
Query: 294 RRGLGAPLTEDQQNRLSEEIEKKWQELEKLPLRENKRVPLTALLNQSRGERRGPPSDGHE 353
R A L + Q+ E+ + L+E+K L +++G +R ++
Sbjct: 2302 RLKAEAELLQQQKELAQEQARR---------LQEDKEQMAQQLAEETQGFQRTLEAERQR 2352
Query: 354 ALEKEVQALRAQL---EAWRLQGEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQ 410
LE +A R +L E R Q A + A R ++ I ++ LA E
Sbjct: 2353 QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE----EIGEKLHRTELATQEKVTL 2408
Query: 411 QVMEELQRHH---------------ERELQRLQQEKEWL-LAEETAATASA------IEA 448
E+QR ERE ++LQQE + L L E T +A
Sbjct: 2409 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2468
Query: 449 MKKAYQEELSRELSKTRSLQQGPDGLRKQHQSDV---EALKRELQVLSEQYSQKCLEIGA 505
+++++ E L + R ++Q L + Q +V + L+ E Q +Q Q+ + A
Sbjct: 2469 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2528
Query: 506 LMRQAEEREHT----LRRCQQEGQELLRHNQELHGRLSEEIDQLR 546
M +A R+H +RR Q+E Q+L + ++ L+EE +LR
Sbjct: 2529 SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2573
Score = 53.9 bits (128), Expect = 5e-07
Identities = 110/489 (22%), Positives = 192/489 (39%), Gaps = 67/489 (13%)
Query: 197 STQKGPLKAGEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPARTPDRL 256
S Q+ +AG R +E +R + +RQ E A+ QRA ++L
Sbjct: 1763 SKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE-----DAARQRAEAERVLAEKL 1817
Query: 257 AKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEG-PRRGLGAPLTEDQQNRLSEEIEK 315
A E R L +E K EA + R + E RR L E+Q + +IE+
Sbjct: 1818 AAIGEATR-LKTEAEIALKEKEAENERLRRLAEDEAFQRRRL-----EEQAAQHKADIEE 1871
Query: 316 KWQELEKLPLRENKRVPLTALLNQSRGERRGPPSDGHEALEKEVQALRA----------- 364
+ +L K E +R L+ + +RR +E+E+ AL+A
Sbjct: 1872 RLAQLRKASDSELERQK--GLVEDTLRQRR--------QVEEEILALKASFEKAAAGKAE 1921
Query: 365 -QLEAWRLQGEAPQSALRSQEDGHIPPGYISQEACE-------------RSLAEMESSHQ 410
+LE R++ A + LRS+E + Q A E +SLA E + +
Sbjct: 1922 LELELGRIRSNA-EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 1980
Query: 411 Q---VMEELQR------HHERELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSREL 461
Q +EE++R R +R +QE L A ++A +KA+ + ++
Sbjct: 1981 QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2040
Query: 462 SKTRSLQQGPDGLRKQHQSDVEALKRELQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQ 521
+ + Q + Q + + EA +R + E Q E RQ EE E L++
Sbjct: 2041 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER-LKQSA 2099
Query: 522 QEGQELLRHNQELHGRLSEEIDQLRGFIASQGMGNGCGRSNERSSCELEVLLRVKENELQ 581
+E + Q +L +E +Q A R + + E+E + E L+
Sbjct: 2100 EEQAQARAQAQAAAEKLRKEAEQEAARRAQ--AEQAALRQKQAADAEMEKHKKFAEQTLR 2157
Query: 582 ---YLKKEVQCLRDELQMMQKDKRFTSGKYQDVYVELSHIKTRSEREIEQLKEHLRLAMA 638
+++E+ LR +L+ K + Q + E T + R+ Q++E L
Sbjct: 2158 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE----ATEAARQRSQVEEELFSVRV 2213
Query: 639 ALQEKESMR 647
++E ++
Sbjct: 2214 QMEELSKLK 2222
Score = 35.8 bits (81), Expect = 0.13
Identities = 52/201 (25%), Positives = 82/201 (40%), Gaps = 48/201 (23%)
Query: 353 EALEKEVQALRAQLE-AWRLQGEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQQ 411
+ +E+E Q L A +E A R Q EA + R QE+ L ++E +Q
Sbjct: 2517 QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE----------------LQQLEQQRRQ 2560
Query: 412 VMEELQRHHER---ELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQ 468
E L ++R +LQ L+++ LA TAS + A K L R
Sbjct: 2561 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK---------TLPNGRDAL 2611
Query: 469 QGP----------DGLRKQHQSDVEALK-RELQVLSEQYSQKCLE----IGALMRQAEER 513
GP DGLR++ V A + +E +LS + Q+ + + L R+ + R
Sbjct: 2612 DGPAAEAEPEHSFDGLRRK----VSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVR 2667
Query: 514 EHTLRRCQQEGQELLRHNQEL 534
+ R G L N++L
Sbjct: 2668 HYLQGRSSIAGLLLKATNEKL 2688
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 63.5 bits (153), Expect = 6e-10
Identities = 107/484 (22%), Positives = 196/484 (40%), Gaps = 44/484 (9%)
Query: 207 EQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPARTPD-----RLAKQEE 261
+QR EV+ R Q++ EL L Q+S + AR + RL +EE
Sbjct: 1380 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1439
Query: 262 LE--RDLAQRSEERRKWFE----ATDSRTPEVPA----GEGPRRGLGAPLTEDQQNRLSE 311
+ R + +E +R E A +R E A + L + ++ Q +
Sbjct: 1440 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1499
Query: 312 EIEKKWQELEKLPLRENKRVPLTAL----LNQSRGERRGPPSDGHEA------LEKEVQA 361
E+E + + K+ L AL L ERR ++ A LE ++
Sbjct: 1500 EVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1559
Query: 362 LRAQLEAWRLQ-GEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQQVMEELQRHH 420
A+L++ R E RS ++ H+ + +EA R A+ ++ ++ EE +R
Sbjct: 1560 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR--AQQQAEAERAREEAEREL 1617
Query: 421 ER-ELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQQGPDGLRKQHQ 479
ER +L+ + + L AEE A S +A + +EE RE + ++ R+ +
Sbjct: 1618 ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1677
Query: 480 SDVEALKRELQVLSEQ---YSQKCLEIGALMRQAEER----EHTLRRCQQEGQELLRHNQ 532
++E ++ + ++Q Q+ + + A Q E++ E L R Q+E + Q
Sbjct: 1678 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ 1737
Query: 533 ELHGRLSEEIDQLRGFIASQGMGNGCGRS-NERSSCELEV---LLRVKENELQYLKKEVQ 588
EL L++ ++ +AS+ RS +E+S LE R E L+ +
Sbjct: 1738 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1797
Query: 589 CLRDELQMMQKDKRFTSGKYQDVYVELSHIKTRSEREIEQLKEHLRLAMAALQEKESMRN 648
+ + Q+ ++D + + V E K + E +LK +A+ + +
Sbjct: 1798 EAKRQRQLAEEDAARQRAEAERVLAE----KLAAIGEATRLKTEAEIALKEKEAENERLR 1853
Query: 649 SLAE 652
LAE
Sbjct: 1854 RLAE 1857
Score = 60.8 bits (146), Expect = 4e-09
Identities = 108/484 (22%), Positives = 198/484 (40%), Gaps = 67/484 (13%)
Query: 206 GEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPARTPDRLAKQEELERD 265
G Q G + R G R + +R +L QA + R ++L +Q R+
Sbjct: 1141 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE 1200
Query: 266 LAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAPLTEDQQNR--------LSEEIEKKW 317
A + W + R ++ A PL + Q R L EEIE+
Sbjct: 1201 SA---DPLGAWLQDARRRQEQIQA---------MPLADSQAVREQLRQEQALLEEIERHG 1248
Query: 318 QELE------KLPLRENKRVPLTALLNQSRGERRGPPS------DGHEALEKEVQALRAQ 365
+++E K + K L + +++ E P+ G E++ +E LR
Sbjct: 1249 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1308
Query: 366 L-EAWRLQGE----APQSALRSQEDGHIPPGYISQEACERS-LAEMESSHQQVMEELQRH 419
E L + ++ R +E+ + Q A ER LAE+E++ ++ + + H
Sbjct: 1309 YSELTTLTSQYIKFISETLRRMEEEERLAE---QQRAEERERLAEVEAALEKQRQLAEAH 1365
Query: 420 H------ERELQRLQQ--EKEWLLAEETAATASAIEAMKKAYQEELSR-------ELSKT 464
ERE + LQQ ++E + EE A A + K++ QEEL + E+
Sbjct: 1366 AQAKAQAEREAKELQQRMQEEVVRREEAAVDA---QQQKRSIQEELQQLRQSSEAEIQAK 1422
Query: 465 RSLQQGPDGLRKQHQSDVEALKRELQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQQEG 524
+ + R + + ++ ++ +L+ Q E+ AL +AEE E R+ Q+E
Sbjct: 1423 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1482
Query: 525 QELLRHNQELHGRLSEEIDQLRGFIASQGMGNGCGRSNERSSCELEVL-LRVKENELQYL 583
+ L R Q+ R + +L + ++ R +R+ LE L L+ +E E +
Sbjct: 1483 ERLRRQVQDESQRKRQAEVELASRVKAEA---EAAREKQRALQALEELRLQAEEAERRLR 1539
Query: 584 KKEVQCLRDELQMMQKDKRFTSGKYQDVYVELSHIKTRSEREIEQLKEHLRLAMAALQEK 643
+ EV+ R ++ +R + Q + + ER +++ EH +A+A L+E+
Sbjct: 1540 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE--EH--VAVAQLREE 1595
Query: 644 ESMR 647
R
Sbjct: 1596 AERR 1599
Score = 59.7 bits (143), Expect = 8e-09
Identities = 80/345 (23%), Positives = 137/345 (39%), Gaps = 50/345 (14%)
Query: 234 ELSPLTQASPQRARTPARTPDRLAKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEGP 293
E + Q + + AR + ++ E DLAQ+ K + E
Sbjct: 2255 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT----- 2309
Query: 294 RRGLGAPLTEDQQNRLSEEIEKKWQELEKLPLRENKRVPLTALLNQSRGERRGPPSDGHE 353
R A L + Q+ E+ + L+E+K L +++G +R ++
Sbjct: 2310 RLKAEAELLQQQKELAQEQARR---------LQEDKEQMAQQLAEETQGFQRTLEAERQR 2360
Query: 354 ALEKEVQALRAQL---EAWRLQGEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQ 410
LE +A R +L E R Q A + A R ++ I ++ LA E
Sbjct: 2361 QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE----EIGEKLHRTELATQEKVTL 2416
Query: 411 QVMEELQRHH---------------ERELQRLQQEKEWL-LAEETAATASA------IEA 448
E+QR ERE ++LQQE + L L E T +A
Sbjct: 2417 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2476
Query: 449 MKKAYQEELSRELSKTRSLQQGPDGLRKQHQSDV---EALKRELQVLSEQYSQKCLEIGA 505
+++++ E L + R ++Q L + Q +V + L+ E Q +Q Q+ + A
Sbjct: 2477 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2536
Query: 506 LMRQAEEREHT----LRRCQQEGQELLRHNQELHGRLSEEIDQLR 546
M +A R+H +RR Q+E Q+L + ++ L+EE +LR
Sbjct: 2537 SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2581
Score = 53.9 bits (128), Expect = 5e-07
Identities = 110/489 (22%), Positives = 192/489 (39%), Gaps = 67/489 (13%)
Query: 197 STQKGPLKAGEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPARTPDRL 256
S Q+ +AG R +E +R + +RQ E A+ QRA ++L
Sbjct: 1771 SKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE-----DAARQRAEAERVLAEKL 1825
Query: 257 AKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEG-PRRGLGAPLTEDQQNRLSEEIEK 315
A E R L +E K EA + R + E RR L E+Q + +IE+
Sbjct: 1826 AAIGEATR-LKTEAEIALKEKEAENERLRRLAEDEAFQRRRL-----EEQAAQHKADIEE 1879
Query: 316 KWQELEKLPLRENKRVPLTALLNQSRGERRGPPSDGHEALEKEVQALRA----------- 364
+ +L K E +R L+ + +RR +E+E+ AL+A
Sbjct: 1880 RLAQLRKASDSELERQK--GLVEDTLRQRR--------QVEEEILALKASFEKAAAGKAE 1929
Query: 365 -QLEAWRLQGEAPQSALRSQEDGHIPPGYISQEACE-------------RSLAEMESSHQ 410
+LE R++ A + LRS+E + Q A E +SLA E + +
Sbjct: 1930 LELELGRIRSNA-EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 1988
Query: 411 Q---VMEELQR------HHERELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSREL 461
Q +EE++R R +R +QE L A ++A +KA+ + ++
Sbjct: 1989 QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2048
Query: 462 SKTRSLQQGPDGLRKQHQSDVEALKRELQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQ 521
+ + Q + Q + + EA +R + E Q E RQ EE E L++
Sbjct: 2049 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER-LKQSA 2107
Query: 522 QEGQELLRHNQELHGRLSEEIDQLRGFIASQGMGNGCGRSNERSSCELEVLLRVKENELQ 581
+E + Q +L +E +Q A R + + E+E + E L+
Sbjct: 2108 EEQAQARAQAQAAAEKLRKEAEQEAARRAQ--AEQAALRQKQAADAEMEKHKKFAEQTLR 2165
Query: 582 ---YLKKEVQCLRDELQMMQKDKRFTSGKYQDVYVELSHIKTRSEREIEQLKEHLRLAMA 638
+++E+ LR +L+ K + Q + E T + R+ Q++E L
Sbjct: 2166 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE----ATEAARQRSQVEEELFSVRV 2221
Query: 639 ALQEKESMR 647
++E ++
Sbjct: 2222 QMEELSKLK 2230
Score = 35.8 bits (81), Expect = 0.13
Identities = 52/201 (25%), Positives = 82/201 (40%), Gaps = 48/201 (23%)
Query: 353 EALEKEVQALRAQLE-AWRLQGEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQQ 411
+ +E+E Q L A +E A R Q EA + R QE+ L ++E +Q
Sbjct: 2525 QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE----------------LQQLEQQRRQ 2568
Query: 412 VMEELQRHHER---ELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQ 468
E L ++R +LQ L+++ LA TAS + A K L R
Sbjct: 2569 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK---------TLPNGRDAL 2619
Query: 469 QGP----------DGLRKQHQSDVEALK-RELQVLSEQYSQKCLE----IGALMRQAEER 513
GP DGLR++ V A + +E +LS + Q+ + + L R+ + R
Sbjct: 2620 DGPAAEAEPEHSFDGLRRK----VSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVR 2675
Query: 514 EHTLRRCQQEGQELLRHNQEL 534
+ R G L N++L
Sbjct: 2676 HYLQGRSSIAGLLLKATNEKL 2696
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 63.5 bits (153), Expect = 6e-10
Identities = 107/484 (22%), Positives = 196/484 (40%), Gaps = 44/484 (9%)
Query: 207 EQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPARTPD-----RLAKQEE 261
+QR EV+ R Q++ EL L Q+S + AR + RL +EE
Sbjct: 1421 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1480
Query: 262 LE--RDLAQRSEERRKWFE----ATDSRTPEVPA----GEGPRRGLGAPLTEDQQNRLSE 311
+ R + +E +R E A +R E A + L + ++ Q +
Sbjct: 1481 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1540
Query: 312 EIEKKWQELEKLPLRENKRVPLTAL----LNQSRGERRGPPSDGHEA------LEKEVQA 361
E+E + + K+ L AL L ERR ++ A LE ++
Sbjct: 1541 EVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1600
Query: 362 LRAQLEAWRLQ-GEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQQVMEELQRHH 420
A+L++ R E RS ++ H+ + +EA R A+ ++ ++ EE +R
Sbjct: 1601 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR--AQQQAEAERAREEAEREL 1658
Query: 421 ER-ELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQQGPDGLRKQHQ 479
ER +L+ + + L AEE A S +A + +EE RE + ++ R+ +
Sbjct: 1659 ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1718
Query: 480 SDVEALKRELQVLSEQ---YSQKCLEIGALMRQAEER----EHTLRRCQQEGQELLRHNQ 532
++E ++ + ++Q Q+ + + A Q E++ E L R Q+E + Q
Sbjct: 1719 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ 1778
Query: 533 ELHGRLSEEIDQLRGFIASQGMGNGCGRS-NERSSCELEV---LLRVKENELQYLKKEVQ 588
EL L++ ++ +AS+ RS +E+S LE R E L+ +
Sbjct: 1779 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1838
Query: 589 CLRDELQMMQKDKRFTSGKYQDVYVELSHIKTRSEREIEQLKEHLRLAMAALQEKESMRN 648
+ + Q+ ++D + + V E K + E +LK +A+ + +
Sbjct: 1839 EAKRQRQLAEEDAARQRAEAERVLAE----KLAAIGEATRLKTEAEIALKEKEAENERLR 1894
Query: 649 SLAE 652
LAE
Sbjct: 1895 RLAE 1898
Score = 60.8 bits (146), Expect = 4e-09
Identities = 108/484 (22%), Positives = 198/484 (40%), Gaps = 67/484 (13%)
Query: 206 GEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPARTPDRLAKQEELERD 265
G Q G + R G R + +R +L QA + R ++L +Q R+
Sbjct: 1182 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE 1241
Query: 266 LAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAPLTEDQQNR--------LSEEIEKKW 317
A + W + R ++ A PL + Q R L EEIE+
Sbjct: 1242 SA---DPLGAWLQDARRRQEQIQA---------MPLADSQAVREQLRQEQALLEEIERHG 1289
Query: 318 QELE------KLPLRENKRVPLTALLNQSRGERRGPPS------DGHEALEKEVQALRAQ 365
+++E K + K L + +++ E P+ G E++ +E LR
Sbjct: 1290 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1349
Query: 366 L-EAWRLQGE----APQSALRSQEDGHIPPGYISQEACERS-LAEMESSHQQVMEELQRH 419
E L + ++ R +E+ + Q A ER LAE+E++ ++ + + H
Sbjct: 1350 YSELTTLTSQYIKFISETLRRMEEEERLAE---QQRAEERERLAEVEAALEKQRQLAEAH 1406
Query: 420 H------ERELQRLQQ--EKEWLLAEETAATASAIEAMKKAYQEELSR-------ELSKT 464
ERE + LQQ ++E + EE A A + K++ QEEL + E+
Sbjct: 1407 AQAKAQAEREAKELQQRMQEEVVRREEAAVDA---QQQKRSIQEELQQLRQSSEAEIQAK 1463
Query: 465 RSLQQGPDGLRKQHQSDVEALKRELQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQQEG 524
+ + R + + ++ ++ +L+ Q E+ AL +AEE E R+ Q+E
Sbjct: 1464 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA 1523
Query: 525 QELLRHNQELHGRLSEEIDQLRGFIASQGMGNGCGRSNERSSCELEVL-LRVKENELQYL 583
+ L R Q+ R + +L + ++ R +R+ LE L L+ +E E +
Sbjct: 1524 ERLRRQVQDESQRKRQAEVELASRVKAEA---EAAREKQRALQALEELRLQAEEAERRLR 1580
Query: 584 KKEVQCLRDELQMMQKDKRFTSGKYQDVYVELSHIKTRSEREIEQLKEHLRLAMAALQEK 643
+ EV+ R ++ +R + Q + + ER +++ EH +A+A L+E+
Sbjct: 1581 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE--EH--VAVAQLREE 1636
Query: 644 ESMR 647
R
Sbjct: 1637 AERR 1640
Score = 59.7 bits (143), Expect = 8e-09
Identities = 80/345 (23%), Positives = 137/345 (39%), Gaps = 50/345 (14%)
Query: 234 ELSPLTQASPQRARTPARTPDRLAKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEGP 293
E + Q + + AR + ++ E DLAQ+ K + E
Sbjct: 2296 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT----- 2350
Query: 294 RRGLGAPLTEDQQNRLSEEIEKKWQELEKLPLRENKRVPLTALLNQSRGERRGPPSDGHE 353
R A L + Q+ E+ + L+E+K L +++G +R ++
Sbjct: 2351 RLKAEAELLQQQKELAQEQARR---------LQEDKEQMAQQLAEETQGFQRTLEAERQR 2401
Query: 354 ALEKEVQALRAQL---EAWRLQGEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQ 410
LE +A R +L E R Q A + A R ++ I ++ LA E
Sbjct: 2402 QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE----EIGEKLHRTELATQEKVTL 2457
Query: 411 QVMEELQRHH---------------ERELQRLQQEKEWL-LAEETAATASA------IEA 448
E+QR ERE ++LQQE + L L E T +A
Sbjct: 2458 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2517
Query: 449 MKKAYQEELSRELSKTRSLQQGPDGLRKQHQSDV---EALKRELQVLSEQYSQKCLEIGA 505
+++++ E L + R ++Q L + Q +V + L+ E Q +Q Q+ + A
Sbjct: 2518 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVA 2577
Query: 506 LMRQAEEREHT----LRRCQQEGQELLRHNQELHGRLSEEIDQLR 546
M +A R+H +RR Q+E Q+L + ++ L+EE +LR
Sbjct: 2578 SMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2622
Score = 53.9 bits (128), Expect = 5e-07
Identities = 110/489 (22%), Positives = 192/489 (39%), Gaps = 67/489 (13%)
Query: 197 STQKGPLKAGEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPARTPDRL 256
S Q+ +AG R +E +R + +RQ E A+ QRA ++L
Sbjct: 1812 SKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE-----DAARQRAEAERVLAEKL 1866
Query: 257 AKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEG-PRRGLGAPLTEDQQNRLSEEIEK 315
A E R L +E K EA + R + E RR L E+Q + +IE+
Sbjct: 1867 AAIGEATR-LKTEAEIALKEKEAENERLRRLAEDEAFQRRRL-----EEQAAQHKADIEE 1920
Query: 316 KWQELEKLPLRENKRVPLTALLNQSRGERRGPPSDGHEALEKEVQALRA----------- 364
+ +L K E +R L+ + +RR +E+E+ AL+A
Sbjct: 1921 RLAQLRKASDSELERQK--GLVEDTLRQRR--------QVEEEILALKASFEKAAAGKAE 1970
Query: 365 -QLEAWRLQGEAPQSALRSQEDGHIPPGYISQEACE-------------RSLAEMESSHQ 410
+LE R++ A + LRS+E + Q A E +SLA E + +
Sbjct: 1971 LELELGRIRSNA-EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 2029
Query: 411 Q---VMEELQR------HHERELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSREL 461
Q +EE++R R +R +QE L A ++A +KA+ + ++
Sbjct: 2030 QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2089
Query: 462 SKTRSLQQGPDGLRKQHQSDVEALKRELQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQ 521
+ + Q + Q + + EA +R + E Q E RQ EE E L++
Sbjct: 2090 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER-LKQSA 2148
Query: 522 QEGQELLRHNQELHGRLSEEIDQLRGFIASQGMGNGCGRSNERSSCELEVLLRVKENELQ 581
+E + Q +L +E +Q A R + + E+E + E L+
Sbjct: 2149 EEQAQARAQAQAAAEKLRKEAEQEAARRAQ--AEQAALRQKQAADAEMEKHKKFAEQTLR 2206
Query: 582 ---YLKKEVQCLRDELQMMQKDKRFTSGKYQDVYVELSHIKTRSEREIEQLKEHLRLAMA 638
+++E+ LR +L+ K + Q + E T + R+ Q++E L
Sbjct: 2207 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE----ATEAARQRSQVEEELFSVRV 2262
Query: 639 ALQEKESMR 647
++E ++
Sbjct: 2263 QMEELSKLK 2271
Score = 35.8 bits (81), Expect = 0.13
Identities = 52/201 (25%), Positives = 82/201 (40%), Gaps = 48/201 (23%)
Query: 353 EALEKEVQALRAQLE-AWRLQGEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQQ 411
+ +E+E Q L A +E A R Q EA + R QE+ L ++E +Q
Sbjct: 2566 QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE----------------LQQLEQQRRQ 2609
Query: 412 VMEELQRHHER---ELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQ 468
E L ++R +LQ L+++ LA TAS + A K L R
Sbjct: 2610 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK---------TLPNGRDAL 2660
Query: 469 QGP----------DGLRKQHQSDVEALK-RELQVLSEQYSQKCLE----IGALMRQAEER 513
GP DGLR++ V A + +E +LS + Q+ + + L R+ + R
Sbjct: 2661 DGPAAEAEPEHSFDGLRRK----VSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVR 2716
Query: 514 EHTLRRCQQEGQELLRHNQEL 534
+ R G L N++L
Sbjct: 2717 HYLQGRSSIAGLLLKATNEKL 2737
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 63.2 bits (152), Expect = 7e-10
Identities = 80/319 (25%), Positives = 141/319 (44%), Gaps = 54/319 (16%)
Query: 357 KEVQALRAQLEAW-RLQGEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQQVMEE 415
K++ ++ L ++ ++Q E PQ L + Y ER E+E Q +ME+
Sbjct: 335 KQIDSINGTLPSYQKMQEEEPQKKLPVTFEDKRKANY------ERGNMELEKRRQALMEQ 388
Query: 416 LQRHHERELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQQGPDGLR 475
QR ER+ Q+ +++EW + ++ + Q EL + L K R L++ + R
Sbjct: 389 QQREAERKAQK--EKEEWERKQR------ELQEQEWKKQLELEKRLEKQRELERQREEER 440
Query: 476 KQHQSDVEALKRELQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQQEGQELLRHN---Q 532
++ EA K+EL+ Q+ LE + RQ L + +E +E++R N +
Sbjct: 441 RKDIERREAAKQELE------RQRRLEWERIRRQ-----ELLNQKNREQEEIVRLNSKKK 489
Query: 533 ELH---GRLSEEIDQLRGFIASQGMGNGCGRSNER---SSCELEVL--------LRVKEN 578
LH L+ + Q+ G + + ++ C+LE++ L+ +N
Sbjct: 490 NLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQN 549
Query: 579 ELQYLKKEVQCLRDELQMMQKDKRFTSGKYQDVYVELSHIKTRSEREI-EQLKEHL---- 633
+L YL E Q L + ++ MQ SG V L H K+ + E+ ++LKE L
Sbjct: 550 KLIYLVPEKQLLNERIKNMQFSNTPDSG------VSLLHKKSLEKEELCQRLKEQLDALE 603
Query: 634 RLAMAALQEKESMRNSLAE 652
+ + L E +S N L E
Sbjct: 604 KETASKLSEMDSFNNQLKE 622
Score = 44.3 bits (103), Expect = 4e-04
Identities = 87/398 (21%), Positives = 170/398 (42%), Gaps = 65/398 (16%)
Query: 221 RKADGQRQALDYVELSPLTQASPQRARTPARTPDRLAKQEELERDLAQRSEERRKWFEAT 280
RKA+ +R + EL QA ++ + R +R A++E+ E + QR + ++W +
Sbjct: 367 RKANYERGNM---ELEKRRQALMEQQQ---REAERKAQKEKEEWERKQRELQEQEWKKQL 420
Query: 281 DSRTPEVPAGEGPRRGLGAPLTEDQQNRLSEEIEKKWQELEKLPLRENKRVPLTALLNQS 340
+ E R+ E+++ + E E QELE+ E +R+ LLNQ
Sbjct: 421 ELEKRLEKQRELERQ------REEERRKDIERREAAKQELERQRRLEWERIRRQELLNQK 474
Query: 341 RGER------RGPPSDGH---EALEKEVQALRAQLEAWRLQGEAPQSALRSQEDGHIPPG 391
E+ + H EAL + Q + +L+ RL+ + ++ L
Sbjct: 475 NREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELE---------- 524
Query: 392 YISQEACERSLAEMESSHQQVMEELQRHHER------ELQRLQQEKEWLLAEETAATASA 445
+ + C+ + E+ +Q+ +ELQ + + E Q L + + + T + +
Sbjct: 525 -VLDKQCDLEIMEI----KQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVS 579
Query: 446 IEAMKKAYQEELSRELSKTRSLQQGPDGLRKQ---HQSDVEALKRELQVLSEQYSQKCLE 502
+ K +EEL + L++ D L K+ S++++ +L+ L E Y+ + L
Sbjct: 580 LLHKKSLEKEELCQR------LKEQLDALEKETASKLSEMDSFNNQLKELRETYNTQQLA 633
Query: 503 IGALMRQAEEREHTLRRCQQEGQELLRHNQELHGRLSEEIDQLRGFIASQGMGNGCGRSN 562
+ L + ++ L+ +++ EL++ +L +E + A QG N + N
Sbjct: 634 LEQLYKIKRDK---LKEIERKRLELMQKK-----KLEDEAARK----AKQGKEN-LWKEN 680
Query: 563 ERSSCELEVLLRVKENELQYLKKEVQCLRDELQMMQKD 600
R E E R++E + Q +E + +E Q KD
Sbjct: 681 LRKE-EEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKD 717
>gi|145312241 differentially expressed in FDCP 6 homolog [Homo
sapiens]
Length = 631
Score = 62.8 bits (151), Expect = 1e-09
Identities = 108/426 (25%), Positives = 165/426 (38%), Gaps = 111/426 (26%)
Query: 94 WKKHWFVLTDSSLKYYRDSTAEEADELDGEI--DLRSCTDVTEYAVQRNYGFQIHTKDAV 151
W + WF L S L Y+ +EE E G I D C +V + F + T +
Sbjct: 233 WAERWFQLQPSCLCYFG---SEECKEKRGIIPLDAHCCVEVLPDRDGKRCMFCVKTANRT 289
Query: 152 YTLSAMTSGIRRNWIEALRKTVRPTSAPDVTKLSDSNKENALHSYSTQKGPLKAGEQRAG 211
Y +SA + R+ W A++ +R A T L K+ K EQR
Sbjct: 290 YEMSASDTRQRQEWTAAIQMAIR-LQAEGKTSLHKDLKQ-------------KRREQREQ 335
Query: 212 SEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPARTPDRLAKQEELERDLAQRSE 271
E +R+A EL L Q ++ R Q + ER L Q E
Sbjct: 336 RE------------RRRAAKEEELLRLQQLQEEKERKLQELELLQEAQRQAER-LLQEEE 382
Query: 272 ERRKWFEATDSRTPEVPAGEGPRRGLGAPLTEDQQNRLSEEIEKKWQELEKLPLRENKRV 331
ERR+ S+ E+ ++ L L E +Q R S + E + +E E R+ +R+
Sbjct: 383 ERRR------SQHREL------QQALEGQLREAEQARASMQAEMELKEEE--AARQRQRI 428
Query: 332 PLTALLNQSRGERRGPPSDGHEALEKEVQALRAQLEAWRLQGEAPQSALRSQEDGHIPPG 391
+ Q EAL+ EV+A R + E+ R+
Sbjct: 429 KELEEMQQRL----------QEALQLEVKARRDE-ESVRI-------------------- 457
Query: 392 YISQEACERSLAEMESSHQQVMEELQRHHERELQRLQQEKEWLLAEETAATASAIEAMKK 451
A R L E E +Q+M +L+ ER ++R QQEKE L
Sbjct: 458 -----AQTRLLEEEEEKLKQLM-QLKEEQERYIERAQQEKEEL----------------- 494
Query: 452 AYQEELSRELSKTRSLQQGPDGL------RKQHQSDVEALKRELQVLSEQYSQKCLEIGA 505
Q+E++++ +RSLQQ L R++ DVEA +R+L+ S +++
Sbjct: 495 --QQEMAQQ---SRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNR 549
Query: 506 LMRQAE 511
LM E
Sbjct: 550 LMHPIE 555
Score = 53.5 bits (127), Expect = 6e-07
Identities = 64/279 (22%), Positives = 120/279 (43%), Gaps = 37/279 (13%)
Query: 375 APQSALRSQEDGHIPPGYISQEACERSLAEMESSHQQVMEELQRHHERELQRLQQ---EK 431
A Q A+R Q +G + + + L + ++ E + E EL RLQQ EK
Sbjct: 306 AIQMAIRLQAEG--------KTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEK 357
Query: 432 EWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQQGPDGLRKQHQSDVEALKRELQV 491
E L +E A ++ QEE R S+ R LQQ +G ++ + +++ E+++
Sbjct: 358 ERKL-QELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAEMEL 416
Query: 492 LSEQYSQKCLEIGALMRQAEEREHTLRRCQQEGQELLRHNQELHGRLSEEIDQLRGFIAS 551
E+ +++ +R L QQ QE L+ E+ R EE ++
Sbjct: 417 KEEEAARQ-----------RQRIKELEEMQQRLQEALQ--LEVKARRDEESVRI------ 457
Query: 552 QGMGNGCGRSNERSSCELEVLLRVKENELQYLKKEVQCLRDELQMMQKDKRFTSGKYQDV 611
R E +L+ L+++KE + +Y+++ Q ++ELQ + + + Q
Sbjct: 458 -----AQTRLLEEEEEKLKQLMQLKEEQERYIER-AQQEKEELQQEMAQQSRSLQQAQQQ 511
Query: 612 YVELSHIKTRSEREIEQLKEHLRLAMAALQEKESMRNSL 650
E+ + R++ ++E + LR A ++ N L
Sbjct: 512 LEEVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNRL 550
>gi|219803769 trichoplein [Homo sapiens]
Length = 498
Score = 62.8 bits (151), Expect = 1e-09
Identities = 94/416 (22%), Positives = 185/416 (44%), Gaps = 30/416 (7%)
Query: 251 RTPDRLAKQEELERDLAQRSEERRKWFEATD---SRTPEVPAGEGPRRGLGA----PLTE 303
R +LA+Q E E L Q+ E+ ++F +D S+ E + +R + A + E
Sbjct: 15 RLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKE 74
Query: 304 DQQNRLS---EEIEKKWQELEKLPLRENKRVPLTALLNQSR-GERRGPPSDGHEALEKEV 359
+++ L E++ + QE + L RE + + L+ L + R E+ G E K +
Sbjct: 75 EKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRKLI 134
Query: 360 QALRAQLEAWRLQGEAPQSALRSQEDGHIPPGY-ISQEACERSLAEMESSHQQVMEELQR 418
A + E W+ + H+ + + +E ++ A E +++ E +R
Sbjct: 135 -AEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYER 193
Query: 419 HHERELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQQGPDGLRKQH 478
L+R++ E+E E+ + ++ M EEL + + L++ + L KQ
Sbjct: 194 ARREALERMKAEEERRQLEDKLQAEALLQQM-----EELKLKEVEATKLKKEQENLLKQ- 247
Query: 479 QSDVEALKRELQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQQEGQELLRHNQELHGRL 538
+ ++E L+ E + + E + QK E+G +R + RR QQ +EL + L L
Sbjct: 248 RWELERLEEERKQM-EAFRQKA-ELGRFLRH-QYNAQLSRRTQQIQEELEADRRILQALL 304
Query: 539 SEEIDQLRGFIASQGMGNGCGRSNERSSCELEVLLRVKENELQYLKKEVQCLRDELQMMQ 598
+E + R +A + +++ E L R +E ELQ L LR+E + M
Sbjct: 305 EKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQML------LREEAKEMW 358
Query: 599 KDKRFTSGKYQDVYVEL-SHIKTRSEREI-EQLKEHLRLAMAALQEKESMRNSLAE 652
+ + + + L S + T +++I E+++++ R +L+ +E + +L E
Sbjct: 359 EKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEE 414
>gi|14150056 trichoplein [Homo sapiens]
Length = 498
Score = 62.8 bits (151), Expect = 1e-09
Identities = 94/416 (22%), Positives = 185/416 (44%), Gaps = 30/416 (7%)
Query: 251 RTPDRLAKQEELERDLAQRSEERRKWFEATD---SRTPEVPAGEGPRRGLGA----PLTE 303
R +LA+Q E E L Q+ E+ ++F +D S+ E + +R + A + E
Sbjct: 15 RLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKMKE 74
Query: 304 DQQNRLS---EEIEKKWQELEKLPLRENKRVPLTALLNQSR-GERRGPPSDGHEALEKEV 359
+++ L E++ + QE + L RE + + L+ L + R E+ G E K +
Sbjct: 75 EKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRKLI 134
Query: 360 QALRAQLEAWRLQGEAPQSALRSQEDGHIPPGY-ISQEACERSLAEMESSHQQVMEELQR 418
A + E W+ + H+ + + +E ++ A E +++ E +R
Sbjct: 135 -AEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYER 193
Query: 419 HHERELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQQGPDGLRKQH 478
L+R++ E+E E+ + ++ M EEL + + L++ + L KQ
Sbjct: 194 ARREALERMKAEEERRQLEDKLQAEALLQQM-----EELKLKEVEATKLKKEQENLLKQ- 247
Query: 479 QSDVEALKRELQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQQEGQELLRHNQELHGRL 538
+ ++E L+ E + + E + QK E+G +R + RR QQ +EL + L L
Sbjct: 248 RWELERLEEERKQM-EAFRQKA-ELGRFLRH-QYNAQLSRRTQQIQEELEADRRILQALL 304
Query: 539 SEEIDQLRGFIASQGMGNGCGRSNERSSCELEVLLRVKENELQYLKKEVQCLRDELQMMQ 598
+E + R +A + +++ E L R +E ELQ L LR+E + M
Sbjct: 305 EKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQML------LREEAKEMW 358
Query: 599 KDKRFTSGKYQDVYVEL-SHIKTRSEREI-EQLKEHLRLAMAALQEKESMRNSLAE 652
+ + + + L S + T +++I E+++++ R +L+ +E + +L E
Sbjct: 359 EKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEE 414
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 61.6 bits (148), Expect = 2e-09
Identities = 79/317 (24%), Positives = 140/317 (44%), Gaps = 54/317 (17%)
Query: 357 KEVQALRAQLEAW-RLQGEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQQVMEE 415
K++ ++ L ++ ++Q E PQ L + Y ER E+E Q +ME+
Sbjct: 335 KQIDSINGTLPSYQKMQEEEPQKKLPVTFEDKRKANY------ERGNMELEKRRQALMEQ 388
Query: 416 LQRHHERELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQQGPDGLR 475
QR ER+ Q+ +++EW + ++ + Q EL + L K R L++ + R
Sbjct: 389 QQREAERKAQK--EKEEWERKQR------ELQEQEWKKQLELEKRLEKQRELERQREEER 440
Query: 476 KQHQSDVEALKRELQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQQEGQELLRHN---Q 532
++ EA K+EL+ Q+ LE + RQ L + +E +E++R N +
Sbjct: 441 RKDIERREAAKQELE------RQRRLEWERIRRQ-----ELLNQKNREQEEIVRLNSKKK 489
Query: 533 ELH---GRLSEEIDQLRGFIASQGMGNGCGRSNER---SSCELEVL--------LRVKEN 578
LH L+ + Q+ G + + ++ C+LE++ L+ +N
Sbjct: 490 NLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQN 549
Query: 579 ELQYLKKEVQCLRDELQMMQKDKRFTSGKYQDVYVELSHIKTRSEREI-EQLKEHL---- 633
+L YL E Q L + ++ MQ SG V L H K+ + E+ ++LKE L
Sbjct: 550 KLIYLVPEKQLLNERIKNMQFSNTPDSG------VSLLHKKSLEKEELCQRLKEQLDALE 603
Query: 634 RLAMAALQEKESMRNSL 650
+ + L E +S N L
Sbjct: 604 KETASKLSEMDSFNNQL 620
Score = 36.2 bits (82), Expect = 0.097
Identities = 89/434 (20%), Positives = 169/434 (38%), Gaps = 78/434 (17%)
Query: 221 RKADGQRQALDYVELSPLTQASPQRARTPARTPDRLAKQEELERDLAQRSEERRKWFEAT 280
RKA+ +R + EL QA ++ + R +R A++E+ E + QR + ++W +
Sbjct: 367 RKANYERGNM---ELEKRRQALMEQQQ---REAERKAQKEKEEWERKQRELQEQEWKKQL 420
Query: 281 DSRTPEVPAGEGPRRGLGAPLTEDQQNRLSEEIEKKWQELEKLPLRENKRVPLTALLNQS 340
+ E R+ E+++ + E E QELE+ E +R+ LLNQ
Sbjct: 421 ELEKRLEKQRELERQ------REEERRKDIERREAAKQELERQRRLEWERIRRQELLNQK 474
Query: 341 RGERRGPPSDGHEALEKEVQALRAQLEAWRLQGEAPQSALRSQEDGHIPPGYISQEACER 400
E ++E+ L ++ + L+ EA + Q G + + ++ +
Sbjct: 475 NRE------------QEEIVRLNSKKKNLHLELEA-LNGKHQQISGRLQDVRLKKQTQKT 521
Query: 401 SLAEMESSHQQVMEELQRHHERELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRE 460
L ++ + E+ + ++ELQ Q + +L+ E ++L E
Sbjct: 522 ELEVLDKQCDLEIMEI-KQLQQELQEYQNKLIYLVPE-----------------KQLLNE 563
Query: 461 LSKTRSLQQGPD-GLRKQHQSDVE------ALKRELQVLSEQYSQKCLEIGALMRQAEER 513
K PD G+ H+ +E LK +L L ++ + K E+ + Q
Sbjct: 564 RIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQL--- 620
Query: 514 EHTLRRCQQEGQELLRHNQELHGRLSE---EIDQLRGFIASQGMGNGCGRSNERSSCELE 570
+C +L+ L L+ + +LR +Q + LE
Sbjct: 621 -----KCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLA-------------LE 662
Query: 571 VLLRVKENELQYLKKEVQCLRDELQMMQKDKRFTSGKYQDVYVELSHIKTRSEREIEQLK 630
L ++K ++L KE++ R EL +K + + K + L R E E +Q +
Sbjct: 663 QLYKIKRDKL----KEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKR 718
Query: 631 EHLRLAMAALQEKE 644
+QE+E
Sbjct: 719 LQEEKTQEKIQEEE 732
>gi|194294525 intersectin 2 isoform 2 [Homo sapiens]
Length = 1249
Score = 61.6 bits (148), Expect = 2e-09
Identities = 79/317 (24%), Positives = 140/317 (44%), Gaps = 54/317 (17%)
Query: 357 KEVQALRAQLEAW-RLQGEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQQVMEE 415
K++ ++ L ++ ++Q E PQ L + Y ER E+E Q +ME+
Sbjct: 335 KQIDSINGTLPSYQKMQEEEPQKKLPVTFEDKRKANY------ERGNMELEKRRQALMEQ 388
Query: 416 LQRHHERELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQQGPDGLR 475
QR ER+ Q+ +++EW + ++ + Q EL + L K R L++ + R
Sbjct: 389 QQREAERKAQK--EKEEWERKQR------ELQEQEWKKQLELEKRLEKQRELERQREEER 440
Query: 476 KQHQSDVEALKRELQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQQEGQELLRHN---Q 532
++ EA K+EL+ Q+ LE + RQ L + +E +E++R N +
Sbjct: 441 RKDIERREAAKQELE------RQRRLEWERIRRQ-----ELLNQKNREQEEIVRLNSKKK 489
Query: 533 ELH---GRLSEEIDQLRGFIASQGMGNGCGRSNER---SSCELEVL--------LRVKEN 578
LH L+ + Q+ G + + ++ C+LE++ L+ +N
Sbjct: 490 NLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQN 549
Query: 579 ELQYLKKEVQCLRDELQMMQKDKRFTSGKYQDVYVELSHIKTRSEREI-EQLKEHL---- 633
+L YL E Q L + ++ MQ SG V L H K+ + E+ ++LKE L
Sbjct: 550 KLIYLVPEKQLLNERIKNMQFSNTPDSG------VSLLHKKSLEKEELCQRLKEQLDALE 603
Query: 634 RLAMAALQEKESMRNSL 650
+ + L E +S N L
Sbjct: 604 KETASKLSEMDSFNNQL 620
Score = 36.2 bits (82), Expect = 0.097
Identities = 89/434 (20%), Positives = 169/434 (38%), Gaps = 78/434 (17%)
Query: 221 RKADGQRQALDYVELSPLTQASPQRARTPARTPDRLAKQEELERDLAQRSEERRKWFEAT 280
RKA+ +R + EL QA ++ + R +R A++E+ E + QR + ++W +
Sbjct: 367 RKANYERGNM---ELEKRRQALMEQQQ---REAERKAQKEKEEWERKQRELQEQEWKKQL 420
Query: 281 DSRTPEVPAGEGPRRGLGAPLTEDQQNRLSEEIEKKWQELEKLPLRENKRVPLTALLNQS 340
+ E R+ E+++ + E E QELE+ E +R+ LLNQ
Sbjct: 421 ELEKRLEKQRELERQ------REEERRKDIERREAAKQELERQRRLEWERIRRQELLNQK 474
Query: 341 RGERRGPPSDGHEALEKEVQALRAQLEAWRLQGEAPQSALRSQEDGHIPPGYISQEACER 400
E ++E+ L ++ + L+ EA + Q G + + ++ +
Sbjct: 475 NRE------------QEEIVRLNSKKKNLHLELEA-LNGKHQQISGRLQDVRLKKQTQKT 521
Query: 401 SLAEMESSHQQVMEELQRHHERELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRE 460
L ++ + E+ + ++ELQ Q + +L+ E ++L E
Sbjct: 522 ELEVLDKQCDLEIMEI-KQLQQELQEYQNKLIYLVPE-----------------KQLLNE 563
Query: 461 LSKTRSLQQGPD-GLRKQHQSDVE------ALKRELQVLSEQYSQKCLEIGALMRQAEER 513
K PD G+ H+ +E LK +L L ++ + K E+ + Q
Sbjct: 564 RIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQL--- 620
Query: 514 EHTLRRCQQEGQELLRHNQELHGRLSE---EIDQLRGFIASQGMGNGCGRSNERSSCELE 570
+C +L+ L L+ + +LR +Q + LE
Sbjct: 621 -----KCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLA-------------LE 662
Query: 571 VLLRVKENELQYLKKEVQCLRDELQMMQKDKRFTSGKYQDVYVELSHIKTRSEREIEQLK 630
L ++K ++L KE++ R EL +K + + K + L R E E +Q +
Sbjct: 663 QLYKIKRDKL----KEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKR 718
Query: 631 EHLRLAMAALQEKE 644
+QE+E
Sbjct: 719 LQEEKTQEKIQEEE 732
>gi|48762942 huntingtin interacting protein-1-related [Homo sapiens]
Length = 1068
Score = 61.2 bits (147), Expect = 3e-09
Identities = 74/290 (25%), Positives = 127/290 (43%), Gaps = 46/290 (15%)
Query: 331 VPLTALLNQSRGERRGPPSDGH----EALEKEVQALRAQLEAWRLQGEAPQSALRSQEDG 386
V + L +Q+ G G D E+L++EV+ LR++LE +L+ + + L+SQ +
Sbjct: 331 VVVADLFDQTFGPPNGSVKDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVN- 389
Query: 387 HIPPGYISQEACERSLAEMESSHQQVM--EELQRHHERELQ--RLQQEKEWLLAEETAAT 442
A E L E Q+ + E RH +L+ +L+ E+ L EE
Sbjct: 390 ----------ALEGELEEQRKQKQKALVDNEQLRHELAQLRAAQLEGERSQGLREEAERK 439
Query: 443 ASAIEA----MKKAYQE-------------ELSRELSKTRSLQQGPDGLRKQHQSDVEAL 485
ASA EA +K+ + E + +++L+ T+ Q+ +++Q VE +
Sbjct: 440 ASATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQV 499
Query: 486 KRELQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQQEGQELLRHNQELHGRLSEEIDQL 545
KRE ++ E+ S ++ L R+ E + L R QE L H ++ LS +D L
Sbjct: 500 KRESELKLEEKSD---QLEKLKRELEAKAGELAR----AQEALSHTEQSKSELSSRLDTL 552
Query: 546 RGFIASQGMGNGCGRSNERSSCELEVLLRVKENELQYLKKEVQCLRDELQ 595
A + +G R E + L+R E L ++ + ELQ
Sbjct: 553 S---AEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQ 599
Score = 46.6 bits (109), Expect = 7e-05
Identities = 67/272 (24%), Positives = 110/272 (40%), Gaps = 19/272 (6%)
Query: 292 GPRRGLGAPLTEDQQNRLSEEIEKKWQELEKLPLRENKRVP-LTALLNQSRGERRGPPSD 350
GP G + Q L E+E ELEK+ L + + L + +N GE
Sbjct: 342 GPPNGSVKDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQ 401
Query: 351 GHEAL--EKEVQALRAQLEAWRLQGEAPQSALRSQEDGHIPPGYISQEACERSLAEMESS 408
+AL ++++ AQL A +L+GE Q LR + + + EA L E S
Sbjct: 402 KQKALVDNEQLRHELAQLRAAQLEGERSQG-LREEAERKAS----ATEARYNKLKEKHSE 456
Query: 409 HQQVMEELQRHHERELQRL-----QQEKEWLLAEETAATASAIEAMKKAYQEELSRELSK 463
V EL R + ++L QE+ + E+ A ++ + EE S +L K
Sbjct: 457 LVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEK 516
Query: 464 TRSLQQGPDGLRKQHQSDVEALKRELQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQ-- 521
+ + G + Q + ++ LS + E AL +RE L Q
Sbjct: 517 LKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSL 576
Query: 522 -QEGQELLRHNQELHGRLSEEIDQLRGFIASQ 552
+E + L Q+ R S+E +L+G +A +
Sbjct: 577 VRETEAALSREQQ---RSSQEQGELQGRLAER 605
>gi|239750456 PREDICTED: similar to KIAA0655 protein [Homo sapiens]
Length = 1048
Score = 61.2 bits (147), Expect = 3e-09
Identities = 74/290 (25%), Positives = 127/290 (43%), Gaps = 46/290 (15%)
Query: 331 VPLTALLNQSRGERRGPPSDGH----EALEKEVQALRAQLEAWRLQGEAPQSALRSQEDG 386
V + L +Q+ G G D E+L++EV+ LR++LE +L+ + + L+SQ +
Sbjct: 311 VVVADLFDQTFGPPNGSVKDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVN- 369
Query: 387 HIPPGYISQEACERSLAEMESSHQQVM--EELQRHHERELQ--RLQQEKEWLLAEETAAT 442
A E L E Q+ + E RH +L+ +L+ E+ L EE
Sbjct: 370 ----------ALEGELEEQRKQKQKALVDNEQLRHELAQLRAAQLEGERSQGLREEAERK 419
Query: 443 ASAIEA----MKKAYQE-------------ELSRELSKTRSLQQGPDGLRKQHQSDVEAL 485
ASA EA +K+ + E + +++L+ T+ Q+ +++Q VE +
Sbjct: 420 ASATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQV 479
Query: 486 KRELQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQQEGQELLRHNQELHGRLSEEIDQL 545
KRE ++ E+ S ++ L R+ E + L R QE L H ++ LS +D L
Sbjct: 480 KRESELKLEEKSD---QLEKLKRELEAKAGELAR----AQEALSHTEQSKSELSSRLDTL 532
Query: 546 RGFIASQGMGNGCGRSNERSSCELEVLLRVKENELQYLKKEVQCLRDELQ 595
A + +G R E + L+R E L ++ + ELQ
Sbjct: 533 S---AEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQ 579
Score = 46.6 bits (109), Expect = 7e-05
Identities = 67/272 (24%), Positives = 110/272 (40%), Gaps = 19/272 (6%)
Query: 292 GPRRGLGAPLTEDQQNRLSEEIEKKWQELEKLPLRENKRVP-LTALLNQSRGERRGPPSD 350
GP G + Q L E+E ELEK+ L + + L + +N GE
Sbjct: 322 GPPNGSVKDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQ 381
Query: 351 GHEAL--EKEVQALRAQLEAWRLQGEAPQSALRSQEDGHIPPGYISQEACERSLAEMESS 408
+AL ++++ AQL A +L+GE Q LR + + + EA L E S
Sbjct: 382 KQKALVDNEQLRHELAQLRAAQLEGERSQG-LREEAERKAS----ATEARYNKLKEKHSE 436
Query: 409 HQQVMEELQRHHERELQRL-----QQEKEWLLAEETAATASAIEAMKKAYQEELSRELSK 463
V EL R + ++L QE+ + E+ A ++ + EE S +L K
Sbjct: 437 LVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEK 496
Query: 464 TRSLQQGPDGLRKQHQSDVEALKRELQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQ-- 521
+ + G + Q + ++ LS + E AL +RE L Q
Sbjct: 497 LKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSL 556
Query: 522 -QEGQELLRHNQELHGRLSEEIDQLRGFIASQ 552
+E + L Q+ R S+E +L+G +A +
Sbjct: 557 VRETEAALSREQQ---RSSQEQGELQGRLAER 585
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.128 0.367
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,844,760
Number of Sequences: 37866
Number of extensions: 1508294
Number of successful extensions: 16086
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 212
Number of HSP's successfully gapped in prelim test: 1121
Number of HSP's that attempted gapping in prelim test: 11201
Number of HSP's gapped (non-prelim): 4220
length of query: 652
length of database: 18,247,518
effective HSP length: 109
effective length of query: 543
effective length of database: 14,120,124
effective search space: 7667227332
effective search space used: 7667227332
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.