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Search of human proteins with 8394456
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|8394456 toll-like receptor 9 isoform A precursor [Homo
sapiens]
(1032 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|8394456 toll-like receptor 9 isoform A precursor [Homo sapiens] 2110 0.0
gi|7706093 toll-like receptor 7 [Homo sapiens] 568 e-162
gi|20302168 toll-like receptor 8 [Homo sapiens] 554 e-157
gi|4507531 toll-like receptor 3 [Homo sapiens] 164 4e-40
gi|16751843 toll-like receptor 5 [Homo sapiens] 152 1e-36
gi|225579152 insulin-like growth factor binding protein, acid la... 147 5e-35
gi|4826772 insulin-like growth factor binding protein, acid labi... 147 5e-35
gi|19924149 toll-like receptor 4 precursor [Homo sapiens] 139 1e-32
gi|19718734 toll-like receptor 2 [Homo sapiens] 128 2e-29
gi|20143971 toll-like receptor 6 [Homo sapiens] 108 3e-23
gi|41350337 toll-like receptor 1 [Homo sapiens] 105 2e-22
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 105 2e-22
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 105 2e-22
gi|62865621 toll-like receptor 10 precursor [Homo sapiens] 94 5e-19
gi|62865618 toll-like receptor 10 precursor [Homo sapiens] 94 5e-19
gi|193083139 leucine rich repeat containing 32 precursor [Homo s... 93 1e-18
gi|5031707 leucine rich repeat containing 32 precursor [Homo sap... 93 1e-18
gi|194440719 chondroadherin-like [Homo sapiens] 93 1e-18
gi|157426829 leucine rich repeat and Ig domain containing 3 [Hom... 93 1e-18
gi|40255157 leucine-rich repeats and immunoglobulin-like domains... 87 8e-17
gi|76880480 hypothetical protein LOC9865 [Homo sapiens] 86 2e-16
gi|209862903 leucine-rich repeats and immunoglobulin-like domain... 86 2e-16
gi|45505137 podocan [Homo sapiens] 85 4e-16
gi|7662320 leucine-rich repeats and immunoglobulin-like domains ... 84 5e-16
gi|54607118 leucine-rich repeats and immunoglobulin-like domains... 84 9e-16
gi|156139147 leucine rich repeat transmembrane neuronal 4 isofor... 84 9e-16
gi|197927168 leucine rich repeat transmembrane neuronal 4 isofor... 84 9e-16
gi|62912474 leucine-rich repeat-containing G protein-coupled rec... 84 9e-16
gi|62912470 leucine-rich repeat-containing G protein-coupled rec... 83 1e-15
gi|38348406 leucine rich repeat containing 33 [Homo sapiens] 83 2e-15
>gi|8394456 toll-like receptor 9 isoform A precursor [Homo sapiens]
Length = 1032
Score = 2110 bits (5466), Expect = 0.0
Identities = 1032/1032 (100%), Positives = 1032/1032 (100%)
Query: 1 MGFCRSALHPLSLLVQAIMLAMTLALGTLPAFLPCELQPHGLVNCNWLFLKSVPHFSMAA 60
MGFCRSALHPLSLLVQAIMLAMTLALGTLPAFLPCELQPHGLVNCNWLFLKSVPHFSMAA
Sbjct: 1 MGFCRSALHPLSLLVQAIMLAMTLALGTLPAFLPCELQPHGLVNCNWLFLKSVPHFSMAA 60
Query: 61 PRGNVTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCPPVGLSPMHFPCHMTIEPSTFL 120
PRGNVTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCPPVGLSPMHFPCHMTIEPSTFL
Sbjct: 61 PRGNVTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCPPVGLSPMHFPCHMTIEPSTFL 120
Query: 121 AVPTLEELNLSYNNIMTVPALPKSLISLSLSHTNILMLDSASLAGLHALRFLFMDGNCYY 180
AVPTLEELNLSYNNIMTVPALPKSLISLSLSHTNILMLDSASLAGLHALRFLFMDGNCYY
Sbjct: 121 AVPTLEELNLSYNNIMTVPALPKSLISLSLSHTNILMLDSASLAGLHALRFLFMDGNCYY 180
Query: 181 KNPCRQALEVAPGALLGLGNLTHLSLKYNNLTVVPRNLPSSLEYLLLSYNRIVKLAPEDL 240
KNPCRQALEVAPGALLGLGNLTHLSLKYNNLTVVPRNLPSSLEYLLLSYNRIVKLAPEDL
Sbjct: 181 KNPCRQALEVAPGALLGLGNLTHLSLKYNNLTVVPRNLPSSLEYLLLSYNRIVKLAPEDL 240
Query: 241 ANLTALRVLDVGGNCRRCDHAPNPCMECPRHFPQLHPDTFSHLSRLEGLVLKDSSLSWLN 300
ANLTALRVLDVGGNCRRCDHAPNPCMECPRHFPQLHPDTFSHLSRLEGLVLKDSSLSWLN
Sbjct: 241 ANLTALRVLDVGGNCRRCDHAPNPCMECPRHFPQLHPDTFSHLSRLEGLVLKDSSLSWLN 300
Query: 301 ASWFRGLGNLRVLDLSENFLYKCITKTKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSF 360
ASWFRGLGNLRVLDLSENFLYKCITKTKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSF
Sbjct: 301 ASWFRGLGNLRVLDLSENFLYKCITKTKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSF 360
Query: 361 GSLVALKELDMHGIFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYV 420
GSLVALKELDMHGIFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYV
Sbjct: 361 GSLVALKELDMHGIFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYV 420
Query: 421 DLSDNRISGASELTATMGEADGGEKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLS 480
DLSDNRISGASELTATMGEADGGEKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLS
Sbjct: 421 DLSDNRISGASELTATMGEADGGEKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLS 480
Query: 481 RNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHS 540
RNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHS
Sbjct: 481 RNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHS 540
Query: 541 FTELPRLEALDLSYNSQPFGMQGVGHNFSFVAHLRTLRHLSLAHNNIHSQVSQQLCSTSL 600
FTELPRLEALDLSYNSQPFGMQGVGHNFSFVAHLRTLRHLSLAHNNIHSQVSQQLCSTSL
Sbjct: 541 FTELPRLEALDLSYNSQPFGMQGVGHNFSFVAHLRTLRHLSLAHNNIHSQVSQQLCSTSL 600
Query: 601 RALDFSGNALGHMWAEGDLYLHFFQGLSGLIWLDLSQNRLHTLLPQTLRNLPKSLQVLRL 660
RALDFSGNALGHMWAEGDLYLHFFQGLSGLIWLDLSQNRLHTLLPQTLRNLPKSLQVLRL
Sbjct: 601 RALDFSGNALGHMWAEGDLYLHFFQGLSGLIWLDLSQNRLHTLLPQTLRNLPKSLQVLRL 660
Query: 661 RDNYLAFFKWWSLHFLPKLEVLDLAGNQLKALTNGSLPAGTRLRRLDVSCNSISFVAPGF 720
RDNYLAFFKWWSLHFLPKLEVLDLAGNQLKALTNGSLPAGTRLRRLDVSCNSISFVAPGF
Sbjct: 661 RDNYLAFFKWWSLHFLPKLEVLDLAGNQLKALTNGSLPAGTRLRRLDVSCNSISFVAPGF 720
Query: 721 FSKAKELRELNLSANALKTVDHSWFGPLASALQILDVSANPLHCACGAAFMDFLLEVQAA 780
FSKAKELRELNLSANALKTVDHSWFGPLASALQILDVSANPLHCACGAAFMDFLLEVQAA
Sbjct: 721 FSKAKELRELNLSANALKTVDHSWFGPLASALQILDVSANPLHCACGAAFMDFLLEVQAA 780
Query: 781 VPGLPSRVKCGSPGQLQGLSIFAQDLRLCLDEALSWDCFALSLLAVALGLGVPMLHHLCG 840
VPGLPSRVKCGSPGQLQGLSIFAQDLRLCLDEALSWDCFALSLLAVALGLGVPMLHHLCG
Sbjct: 781 VPGLPSRVKCGSPGQLQGLSIFAQDLRLCLDEALSWDCFALSLLAVALGLGVPMLHHLCG 840
Query: 841 WDLWYCFHLCLAWLPWRGRQSGRDEDALPYDAFVVFDKTQSAVADWVYNELRGQLEECRG 900
WDLWYCFHLCLAWLPWRGRQSGRDEDALPYDAFVVFDKTQSAVADWVYNELRGQLEECRG
Sbjct: 841 WDLWYCFHLCLAWLPWRGRQSGRDEDALPYDAFVVFDKTQSAVADWVYNELRGQLEECRG 900
Query: 901 RWALRLCLEERDWLPGKTLFENLWASVYGSRKTLFVLAHTDRVSGLLRASFLLAQQRLLE 960
RWALRLCLEERDWLPGKTLFENLWASVYGSRKTLFVLAHTDRVSGLLRASFLLAQQRLLE
Sbjct: 901 RWALRLCLEERDWLPGKTLFENLWASVYGSRKTLFVLAHTDRVSGLLRASFLLAQQRLLE 960
Query: 961 DRKDVVVLVILSPDGRRSRYVRLRQRLCRQSVLLWPHQPSGQRSFWAQLGMALTRDNHHF 1020
DRKDVVVLVILSPDGRRSRYVRLRQRLCRQSVLLWPHQPSGQRSFWAQLGMALTRDNHHF
Sbjct: 961 DRKDVVVLVILSPDGRRSRYVRLRQRLCRQSVLLWPHQPSGQRSFWAQLGMALTRDNHHF 1020
Query: 1021 YNRNFCQGPTAE 1032
YNRNFCQGPTAE
Sbjct: 1021 YNRNFCQGPTAE 1032
>gi|7706093 toll-like receptor 7 [Homo sapiens]
Length = 1049
Score = 568 bits (1464), Expect = e-162
Identities = 372/1042 (35%), Positives = 553/1042 (53%), Gaps = 39/1042 (3%)
Query: 13 LLVQAIMLAMTLALGTLPAFLPCEL-----QPHGLVNCNWLFLKSVPHFSMAAPRGNVTS 67
+L I+++ L P LPC++ + H +V+C L +P N T+
Sbjct: 14 ILFNIILISKLLGARWFPKTLPCDVTLDVPKNHVIVDCTDKHLTEIP----GGIPTNTTN 69
Query: 68 LSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCPPVGLSPMHFPC--HMTIEPSTFLAVPTL 125
L+L+ N I + + F L L ++ + NC P+ L + C + I+P +F + L
Sbjct: 70 LTLTINHIPDISPASFHRLDHLVEIDFRCNCVPIPLGSKNNMCIKRLQIKPRSFSGLTYL 129
Query: 126 EELNLSYNNIMTVP-ALPKSLISLSLSHTNILMLDSASLAGLHALRFLFMDGNCYYKNPC 184
+ L L N ++ +P LP SL LSL NI + +L L + L++ NCYY+NPC
Sbjct: 130 KSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKENLTELANIEILYLGQNCYYRNPC 189
Query: 185 RQALEVAPGALLGLGNLTHLSLKYNNLTVVPRNLPSSLEYLLLSYNRIVKLAPEDLANLT 244
+ + A L L L LSLK NN+T VP LPS+L L L N I K+ +D NL
Sbjct: 190 YVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTVLPSTLTELYLYNNMIAKIQEDDFNNLN 249
Query: 245 ALRVLDVGGNCRRCDHAPNPCMECPRHFP-QLHPDTFSHLSRLEGLVLKDSSLSWLNASW 303
L++LD+ GNC RC +AP PC C + P Q+ + F L+ L+ L L +SL + W
Sbjct: 250 QLQILDLSGNCPRCYNAPFPCAPCKNNSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRW 309
Query: 304 FRGLGNLRVLDLSENFLYKCITKTKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSFGSL 363
F+ + L+ LDLS+NFL K I K L L +L+LSFN++ +V A ++L+ +F SL
Sbjct: 310 FKNINKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASMNLSQAFSSL 369
Query: 364 VALKELDMHGIFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYVDLS 423
+LK L + G F+ L L PL L L+ L L NFI A L +F+ F L+ +DLS
Sbjct: 370 KSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQFKRLKVIDLS 429
Query: 424 DNRISGASELTATMGEADGG------------EKVWLQPGDLAPAPVDTPSSE----DFR 467
N+IS + + ++ +G E++ D + E
Sbjct: 430 VNKISPSGD-SSEVGFCSNARTSVESYEPQVLEQLHYFRYDKYARSCRFKNKEASFMSVN 488
Query: 468 PNCSTLNFTLDLSRNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLD 527
+C TLDLS+N++ V+ F LS L+CL LS N ISQ +NGS+F PL L+ LD
Sbjct: 489 ESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLD 548
Query: 528 LSHNKLDLYHEHSFTELPRLEALDLSYNSQPFGMQGVGHNFSFVAHLRTLRHLSLAHNNI 587
S+N+LDL H +F EL +LE LD+S NS F +G+ H +F +L+ L+ L + N+I
Sbjct: 549 FSNNRLDLLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDI 608
Query: 588 HSQVSQQLCSTSLRALDFSGNALGHMWAEGD-LYLHFFQGLSGLIWLDLSQNRLHTLLPQ 646
S S+ + S SLR L+F GN L +W EGD YL F+ L L LD+S+N L L
Sbjct: 609 SSSTSRTMESESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKNSLSFLPSG 668
Query: 647 TLRNLPKSLQVLRLRDNYLAFFKWWSLHFLPKLEVLDLAGNQLKALTNGSLPAGTRLRRL 706
+P +L+ L L N L F W L L LE LDL+ NQL + L+ L
Sbjct: 669 VFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSNCSRSLKNL 728
Query: 707 DVSCNSISFVAPGFFSKAKELRELNLSANALKTVDHSWFGP-LASALQILDVSANPLHCA 765
+ N I + F A +LR L+LS+N ++ + + F + + L++L + N C
Sbjct: 729 ILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHNRFLCT 788
Query: 766 CGAA-FMDFLLEVQAAVPGLPSRVKCGSPGQLQGLSIFAQDLRLCLDEALSWDCFALSLL 824
C A F+ ++ + +P L + V C PG +G S+ + DL C + + F+LS +
Sbjct: 789 CDAVWFVWWVNHTEVTIPYLATDVTCVGPGAHKGQSVISLDLYTCELDLTNLILFSLS-I 847
Query: 825 AVALGLGVPM-LHHLCGWDLWYCFHLCLAWLPWRGRQSGRDEDALPYDAFVVFDKTQSAV 883
+V+L L V M HL WD+WY +H C A + +G Q D YDAF+V+D AV
Sbjct: 848 SVSLFLMVMMTASHLYFWDVWYIYHFCKAKI--KGYQRLISPDCC-YDAFIVYDTKDPAV 904
Query: 884 ADWVYNELRGQLEECRGRWALRLCLEERDWLPGKTLFENLWASVYGSRKTLFVLAHTDRV 943
+WV EL +LE+ R + LCLEERDWLPG+ + ENL S+ S+KT+FV+
Sbjct: 905 TEWVLAELVAKLEDPREK-HFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDKYAK 963
Query: 944 SGLLRASFLLAQQRLLEDRKDVVVLVILSPDGRRSRYVRLRQRLCRQSVLLWPHQPSGQR 1003
+ + +F L+ QRL++++ DV++L+ L ++S++++LR+RLC SVL WP P
Sbjct: 964 TENFKIAFYLSHQRLMDEKVDVIILIFLEKPFQKSKFLQLRKRLCGSSVLEWPTNPQAHP 1023
Query: 1004 SFWAQLGMALTRDNHHFYNRNF 1025
FW L AL DNH Y++ F
Sbjct: 1024 YFWQCLKNALATDNHVAYSQVF 1045
>gi|20302168 toll-like receptor 8 [Homo sapiens]
Length = 1041
Score = 554 bits (1427), Expect = e-157
Identities = 353/979 (36%), Positives = 524/979 (53%), Gaps = 27/979 (2%)
Query: 65 VTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCPPV---GLSPMHFPCHMTIEPSTFLA 121
VT L LS N I H+ + F L +L +NL N P V +P + I FL
Sbjct: 65 VTELDLSDNFITHITNESFQGLQNLTKINLNHN-PNVQHQNGNPGIQSNGLNITDGAFLN 123
Query: 122 VPTLEELNLSYNNIMTVPA-LPKSLISLSLSHTNILMLDSASLAGLHALRFLFMDGNCYY 180
+ L EL L N + +P+ LP+SL LSL NI + ++ L L+ L++ NCY+
Sbjct: 124 LKNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYF 183
Query: 181 KNPCRQALEVAPGALLGLGNLTHLSLKYNNLTVVPRNLPSSLEYLLLSYNRIVKLAPEDL 240
C + + G L NL LSL +N+L+ VP LPSSL L LS +I ++ ED
Sbjct: 184 NKVCEKT-NIEDGVFETLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDF 242
Query: 241 ANLTALRVLDVGGNCRRCDHAPNPCMECPRHFP-QLHPDTFSHLSRLEGLVLKDSSLSWL 299
L L +LD+ GNC RC +AP PC+ C + F +L++L L L +SL +
Sbjct: 243 KGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLRKI 302
Query: 300 NASWFRGLGNLRVLDLSENFLYKCITKTKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPS 359
NA+WF+ + +L+VLDL N+L I L +L L+LSFNY K H++++ +
Sbjct: 303 NAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINISRN 362
Query: 360 FGSLVALKELDMHGIFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRY 419
F L++L+ L + G F+ L E +PL +LP L T+ L +NFI Q +F+ F L
Sbjct: 363 FSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEI 422
Query: 420 VDLSDNRISGASELTATMGEADGGEKVWLQPGDLAPAPVDTPSS------EDFRPNCSTL 473
+ LS+NRIS + T + ++ D S+ +P C+
Sbjct: 423 IYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCAAY 482
Query: 474 NFTLDLSRNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKL 533
LDLS N++ + P F L + CL LS N +Q ++G++F + ++ LDL++N+L
Sbjct: 483 GKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRL 542
Query: 534 DLYHEHSFTELPRLEALDLSYNSQPFGMQGVGHNFSFVAHLRTLRHLSLAHNNIHSQVSQ 593
D + + TEL LE LDLSYNS F + GV H+ F+ + L+ L+L+HNNI++ +
Sbjct: 543 DFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDK 602
Query: 594 -QLCSTSLRALDFSGNALGHMWAEGD-LYLHFFQGLSGLIWLDLSQNRLHTLLPQTLRNL 651
L S SL L FSGN L +W + D Y+ F+GL L LDLS NRL + + NL
Sbjct: 603 YNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNL 662
Query: 652 PKSLQVLRLRDNYLAFFKWWSLHFLPKLEVLDLAGNQLKALTNGSLPAGTRLRRLDVSCN 711
P SL L + DN L FF W L P+LE+LDL GN+L LT+ + LR L +S N
Sbjct: 663 PASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHN 722
Query: 712 SISFVAPGFFSKAKELRELNLSANALKTVDHSWFGPLASA-LQILDVSANPLHCACGAA- 769
IS + GF S+ L+ L+LS+N LKT++ S + L +L++ NP C C
Sbjct: 723 RISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFECTCDIGD 782
Query: 770 ---FMDFLLEVQAAVPGLPSRVKCGSPGQLQGLSIFAQDLRLCLDEALSWDCFALSLLAV 826
+MD L V+ +P L V C SPG +G SI + +L C+ + + F +
Sbjct: 783 FRRWMDEHLNVK--IPRLVD-VICASPGDQRGKSIVSLELTTCVSDVTAVILFFFTFFIT 839
Query: 827 ALGLGVPMLHHLCGWDLWYCFHLCLAWLPWRGRQSGRDEDALPYDAFVVFDKTQSAVADW 886
+ + + HHL WD+W+ +++CLA + +G +S YDA++ +D ++V DW
Sbjct: 840 TMVMLAALAHHLFYWDVWFIYNVCLAKV--KGYRSLSTSQTF-YDAYISYDTKDASVTDW 896
Query: 887 VYNELRGQLEECRGRWALRLCLEERDWLPGKTLFENLWASVYGSRKTLFVLAHTDRVSGL 946
V NELR LEE R + L LCLEERDW PG + +NL S+ S+KT+FVL S
Sbjct: 897 VINELRYHLEESRDKNVL-LCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWN 955
Query: 947 LRASFLLAQQRLLEDRKDVVVLVILSPDGRRSRYVRLRQRLCRQSVLLWPHQPSGQRSFW 1006
+ +F LA QRL+++ DV++ ++L P + S+Y+RLRQR+C+ S+L WP P + FW
Sbjct: 956 FKTAFYLALQRLMDENMDVIIFILLEPVLQHSQYLRLRQRICKSSILQWPDNPKAEGLFW 1015
Query: 1007 AQLGMALTRDNHHFYNRNF 1025
L + +N YN +
Sbjct: 1016 QTLRNVVLTENDSRYNNMY 1034
Score = 33.9 bits (76), Expect = 0.81
Identities = 21/67 (31%), Positives = 29/67 (43%), Gaps = 15/67 (22%)
Query: 46 NWLFLKSVPHFSMAAPRGN---------------VTSLSLSSNRIHHLHDSDFAHLPSLR 90
NW L+ P + RGN + +L LS NRI HL + + SL+
Sbjct: 680 NWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLK 739
Query: 91 HLNLKWN 97
HL+L N
Sbjct: 740 HLDLSSN 746
>gi|4507531 toll-like receptor 3 [Homo sapiens]
Length = 904
Score = 164 bits (415), Expect = 4e-40
Identities = 218/888 (24%), Positives = 356/888 (40%), Gaps = 109/888 (12%)
Query: 211 LTVVPRNLPSSLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGNCRRCDHAPNPCMECP- 269
LT VP +LP+++ L L++N++ +L + + L LDVG N P C + P
Sbjct: 42 LTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTIS-KLEPELCQKLPM 100
Query: 270 --------RHFPQLHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSENFL- 320
QL TF+ + L L L +S+ + + F NL LDLS N L
Sbjct: 101 LKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHNGLS 160
Query: 321 -------------YKCITKTKAFQGL----------TQLRKLNLSFNYQKRVS------- 350
+ + Q L + L+KL LS N K S
Sbjct: 161 STKLGTQVQLENLQELLLSNNKIQALKSEELDIFANSSLKKLELSSNQIKEFSPGCFHAI 220
Query: 351 -------FAHLSLAPSFGSLVAL-------KELDMHGIFFRSLDETTLRPLARLPMLQTL 396
++ L PS + L + L + + TT L + L L
Sbjct: 221 GRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGL-KWTNLTML 279
Query: 397 RLQMNFINQAQLGIFRAFPGLRYVDLSDNRISG--ASELTATMGEADGGEKVWLQPGDLA 454
L N +N F P L Y L N I + L K ++
Sbjct: 280 DLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTKQSIS 339
Query: 455 PAPVDTPSSEDFRPNCSTLNFTLDLSRNNLVTVQPEMFAQLSHLQCLRLSHNCIS-QAVN 513
A + P +DF L++ N++ ++ MF L +L+ L LS++ S + +
Sbjct: 340 LASL--PKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRTLT 397
Query: 514 GSQFLPL--TGLQVLDLSHNKLDLYHEHSFTELPRLEALDLSYNS---QPFGMQGVGHNF 568
F+ L + L +L+L+ NK+ +F+ L LE LDL N + G + G
Sbjct: 398 NETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLEN 457
Query: 569 SFVAHLRTLRHLSLAHNNIHSQVSQQ---LCSTSLRALDFSGNALGHMWAEGDLYLHFFQ 625
F +L ++L L N+ S Q L +L+ +D S + FQ
Sbjct: 458 IFEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPSP--------------FQ 503
Query: 626 GLSGLIWLDLSQNRLHTLLPQTLRNLPKSLQVLRLRDNYLAFFKWWS----------LHF 675
L L LDLS N + + L L K L++L L+ N LA + W L
Sbjct: 504 PLRNLTILDLSNNNIANINDDMLEGLEK-LEILDLQHNNLA--RLWKHANPGGPIYFLKG 560
Query: 676 LPKLEVLDLAGNQLKALTNGSLPAGTRLRRLDVSCNSISFVAPGFFSKAKELRELNLSAN 735
L L +L+L N + L+ +D+ N+++ + F+ L+ LNL N
Sbjct: 561 LSHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKN 620
Query: 736 ALKTVDHSWFGPLASALQILDVSANPLHCACG--AAFMDFLLEVQAAVPGLPSRVKCGSP 793
+ +V+ FGP L LD+ NP C C A F++++ E +P L S C +P
Sbjct: 621 LITSVEKKVFGPAFRNLTELDMRFNPFDCTCESIAWFVNWINETHTNIPELSSHYLCNTP 680
Query: 794 GQLQGLSIFAQDLRLCLDEALSWDCFALSLLAVALGLGVPMLHHLCGWDLWYCFHLCLAW 853
G + D C D A F ++ + + + + +L H GW + + +++ +
Sbjct: 681 PHYHGFPVRLFDTSSCKDSAPFELFFMINTSILLIFIFIVLLIHFEGWRISFYWNVSVHR 740
Query: 854 LPWRGRQSGRDEDALPYDAFVVFDKTQSAVADWVYNELRGQLEECRGRWALRLCLEERDW 913
+ ++ R + Y A+++ DWV+ +E + +L+ CLEERD+
Sbjct: 741 V-LGFKEIDRQTEQFEYAAYIIHAYKDK---DWVWEHFSSMEKEDQ---SLKFCLEERDF 793
Query: 914 LPGKTLFENLWASVYGSRKTLFVLAHTDRVSGLL-RASFLLAQQRLLEDRKDVVVLVILS 972
G E + S+ SRK +FV+ H L R A Q+ +E D ++LV L
Sbjct: 794 EAGVFELEAIVNSIKRSRKIIFVITHHLLKDPLCKRFKVHHAVQQAIEQNLDSIILVFLE 853
Query: 973 --PDGRRSRYVRLRQRLCRQSVLL-WPHQPSGQRSFWAQLGMALTRDN 1017
PD + + + LR+ + + +L WP Q +F +L +AL N
Sbjct: 854 EIPDYKLNHALCLRRGMFKSHCILNWPVQKERIGAFRHKLQVALGSKN 901
Score = 82.4 bits (202), Expect = 2e-15
Identities = 159/647 (24%), Positives = 245/647 (37%), Gaps = 147/647 (22%)
Query: 65 VTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCPPVGLSPMHFPCHMTIEPSTFLAVPT 124
+TSL + N I L LP L+ LNL+ N LS + TF
Sbjct: 77 LTSLDVGFNTISKLEPELCQKLPMLKVLNLQHN----ELS--------QLSDKTFAFCTN 124
Query: 125 LEELNLSYNNIMTVPALP----KSLISLSLSHTNILMLDSASLAGLHALRFLFMDGN--- 177
L EL+L N+I + P K+LI+L LSH + + L L+ L + N
Sbjct: 125 LTELHLMSNSIQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQ 184
Query: 178 -------CYYKNPCRQALEV--------APGALLGLGNLTHLSLKYNNLTVVP------- 215
+ N + LE+ +PG +G L L L NN+ + P
Sbjct: 185 ALKSEELDIFANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFL--NNVQLGPSLTEKLC 242
Query: 216 -RNLPSSLEYLLLSYNRIVKLAPEDLANL--TALRVLDVGGNCRRCDHAPNPCMECPRHF 272
+S+ L LS +++ + L T L +LD+ N +
Sbjct: 243 LELANTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYN----------------NL 286
Query: 273 PQLHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSENFLYKCITKTKAFQG 332
+ D+F+ L +LE L+ +++ L + GL N+R L+L +F TK
Sbjct: 287 NVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSF-------TKQSIS 339
Query: 333 LTQLRKLNLSFNYQKRVSFAHLSLAPS---------FGSLVALKELDMHGIF--FRSLDE 381
L L K++ F++Q HL++ + F L+ LK L + F R+L
Sbjct: 340 LASLPKID-DFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTN 398
Query: 382 TTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYVDLSDNRISGASELTATMGEAD 441
T LA P L L L N I++ + F L +DL N I ELT E
Sbjct: 399 ETFVSLAHSP-LHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEI--GQELTGQ--EWR 453
Query: 442 GGEKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLSRNNLVTVQPEMFAQLSHLQCL 501
G E + F + LS N + + FA + LQ L
Sbjct: 454 GLENI----------------------------FEIYLSYNKYLQLTRNSFALVPSLQRL 485
Query: 502 RLSHNCISQAVNG-SQFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEALDLSYN--SQP 558
L + + S F PL L +LDLS+N + ++ L +LE LDL +N ++
Sbjct: 486 MLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNNLARL 545
Query: 559 FGMQGVGHNFSFVAHLRTLRHLSLAHNNIHSQVSQQLCSTSLRALDFSGNALGHMWAEGD 618
+ G F+ L L L+L N +
Sbjct: 546 WKHANPGGPIYFLKGLSHLHILNLESNGF-----------------------------DE 576
Query: 619 LYLHFFQGLSGLIWLDLSQNRLHTLLPQTLRNLPKSLQVLRLRDNYL 665
+ + F+ L L +DL N L+T LP ++ N SL+ L L+ N +
Sbjct: 577 IPVEVFKDLFELKIIDLGLNNLNT-LPASVFNNQVSLKSLNLQKNLI 622
Score = 81.6 bits (200), Expect = 3e-15
Identities = 144/545 (26%), Positives = 210/545 (38%), Gaps = 123/545 (22%)
Query: 64 NVTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCPPVGLSPMHFPCHMTIEPSTFLAVP 123
N+T L L SN I + ++ F +L L+L N GLS + +E
Sbjct: 124 NLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHN----GLSSTKLGTQVQLE-------- 171
Query: 124 TLEELNLSYNNIMTVPA------LPKSLISLSLSHTNILMLDSASLAGLHALRFLFMD-- 175
L+EL LS N I + + SL L LS I + L LF++
Sbjct: 172 NLQELLLSNNKIQALKSEELDIFANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNV 231
Query: 176 --GNCYYKNPCRQALEVAPGALLGLG--------------------NLTHLSLKYNNLTV 213
G + C LE+A ++ L NLT L L YNNL V
Sbjct: 232 QLGPSLTEKLC---LELANTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNV 288
Query: 214 VPRN----LPSSLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGNCRRCDHAPNPCMECP 269
V + LP LEY L YN I L L L +R L N +R + +
Sbjct: 289 VGNDSFAWLPQ-LEYFFLEYNNIQHLFSHSLHGLFNVRYL----NLKRSFTKQSISLAS- 342
Query: 270 RHFPQLHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSENFLYKCITKTKA 329
P++ +F L LE L ++D+ + + ++ F GL NL+ L LS +F
Sbjct: 343 --LPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNSF---------- 390
Query: 330 FQGLTQLRKL-NLSFNYQKRVSFAHLSLAPSFGSLVALKELDMHGIFFRSLDETTLRPLA 388
T LR L N +F VS AH L + + + + +
Sbjct: 391 ----TSLRTLTNETF-----VSLAH-------------SPLHILNLTKNKISKIESDAFS 428
Query: 389 RLPMLQTLRLQMNFINQAQLG--------IFRAFPGL-RYVDLSDNRISGASELTATMGE 439
L L+ L L +N I Q G IF + +Y+ L+ N + L M
Sbjct: 429 WLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVPSLQRLM-- 486
Query: 440 ADGGEKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFT-LDLSRNNLVTVQPEMFAQLSHL 498
+V L+ D +P+P F+P N T LDLS NN+ + +M L L
Sbjct: 487 ---LRRVALKNVDSSPSP--------FQP---LRNLTILDLSNNNIANINDDMLEGLEKL 532
Query: 499 QCLRLSHNCISQ----AVNGSQFLPLTG---LQVLDLSHNKLDLYHEHSFTELPRLEALD 551
+ L L HN +++ A G L G L +L+L N D F +L L+ +D
Sbjct: 533 EILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELKIID 592
Query: 552 LSYNS 556
L N+
Sbjct: 593 LGLNN 597
Score = 30.8 bits (68), Expect = 6.9
Identities = 29/103 (28%), Positives = 47/103 (45%), Gaps = 26/103 (25%)
Query: 61 PRGNVTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWN-----------CPPV----GLSP 105
P N+T L LS+N I +++D L L L+L+ N P+ GLS
Sbjct: 504 PLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSH 563
Query: 106 MHFPCHMTIEPSTFLAVPT--------LEELNLSYNNIMTVPA 140
+H + +E + F +P L+ ++L NN+ T+PA
Sbjct: 564 LHI---LNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTLPA 603
>gi|16751843 toll-like receptor 5 [Homo sapiens]
Length = 858
Score = 152 bits (385), Expect = 1e-36
Identities = 199/829 (24%), Positives = 339/829 (40%), Gaps = 82/829 (9%)
Query: 207 KYNNLTVVPRNLPSSLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGNCRRCDHAPNPCM 266
++ NLT VP+ L ++ E LLLS+N I + L L++L++G + P
Sbjct: 34 RFCNLTQVPQVL-NTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQ-----YTPLT-- 85
Query: 267 ECPRHFPQLHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSENFLYKCITK 326
+ + F +L L L L S + +L+ F+GL +L L L L + K
Sbjct: 86 --------IDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLK 137
Query: 327 TKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSFGSLVALKELDMHGIFFRSLDETTLRP 386
F+ L L +L+LS N L L PSFG L +LK +D + E L P
Sbjct: 138 DGYFRNLKALTRLDLSKN-----QIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEP 192
Query: 387 LARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYVDLSDNRISGAS---ELTATMGEADGG 443
L + + ++ + + R + L +SG ++T A
Sbjct: 193 LQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISK 252
Query: 444 EKVW-------LQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLSRNNLVTVQPEMFAQLS 496
+ + + + P F + LDLS + ++ +F L
Sbjct: 253 SQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLK 312
Query: 497 HLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEALDLSYNS 556
L+ L L++N I++ + + F L LQVL+LS+N L + +F LP++ +DL N
Sbjct: 313 DLKVLNLAYNKINKIADEA-FYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNH 371
Query: 557 QPFGMQGVGHNFSFVAHLRTLRHLSLAHNNIH-------------SQVSQQLCSTSLRAL 603
F F+ L+TL A IH V+ + + +
Sbjct: 372 IAIIQD---QTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLI 428
Query: 604 DFSGNALGHMWAEGDLYLHFFQGLSGLIWLDLSQNRLHTLLPQTLRNLPKSLQVLRLRDN 663
S N L ++ D+ L+F + L L L+QNR + + SL+ L L +N
Sbjct: 429 HLSENRLENL----DI-LYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGEN 483
Query: 664 YLAF-----FKWWSLHFLPKLEVLDLAGNQLKALTNGSLPAGTRLRRLDVSCNSISFVAP 718
L W L L+VL L N L +L G T LR L ++ N ++ ++
Sbjct: 484 MLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSH 543
Query: 719 GFFSKAKELRELNLSANALKTVDHSWFGPLASALQILDVSANPLHCACG-AAFMDFLLEV 777
E+ L++S N L + F +L +LD++ N C C + F+++L
Sbjct: 544 NDLPANLEI--LDISRNQLLAPNPDVF----VSLSVLDITHNKFICECELSTFINWLNHT 597
Query: 778 QAAVPGLPSRVKCGSPGQLQGLSIFAQDLRLCLDE----ALSWDCFALSLLAVALGLGVP 833
+ G P+ + C P G+S+F+ C +E +L + F + + + L L
Sbjct: 598 NVTIAGPPADIYCVYPDSFSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTI 657
Query: 834 MLHHLCGWDLWYCFHLCLAWLPWRGRQSGRDEDALPYDAFVVFDKTQSAVADWVYNELRG 893
+ + C+ L ++ G + D YDA++ F WV N L
Sbjct: 658 LTVTKFRGFCFICYKTAQR-LVFKDHPQGTEPDMYKYDAYLCFSSKDFT---WVQNALLK 713
Query: 894 QLE-ECRGRWALRLCLEERDWLPGKTLFENLWASVYGSRKTLFVLAHTDRVSGLLRASFL 952
L+ + + LC EERD++PG+ N+ +++ SRK + +++ G +F
Sbjct: 714 HLDTQYSDQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFS 773
Query: 953 LAQQRLLEDRKDVVVLVILSPDGRRSRYVRLRQRLCR-----QSVLLWP 996
AQ R L D +++V++ G S+Y ++ + R Q L WP
Sbjct: 774 YAQGRCLSDLNSALIMVVV---GSLSQYQLMKHQSIRGFVQKQQYLRWP 819
Score = 44.7 bits (104), Expect = 5e-04
Identities = 67/269 (24%), Positives = 110/269 (40%), Gaps = 57/269 (21%)
Query: 64 NVTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCPPVGLSPMHFPCHMTIEPSTFLAVP 123
N+ L+LS N + L+ S+F LP + +++L+ N + I+ TF +
Sbjct: 337 NLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAI------------IQDQTFKFLE 384
Query: 124 TLEELNLSYNNIMTVPALPKSLISLSLSHTNILMLDSASLAG--LHALRFLFMDGNCYYK 181
L+ L+L N + T+ +P S+ + LS ++ L +L +H + + Y
Sbjct: 385 KLQTLDLRDNALTTIHFIP-SIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILY- 442
Query: 182 NPCRQALEVAPGALLGLGNLTHLSLKYNNLT-----VVPRNLPSSLEYLLLSYNRI---- 232
LL + +L L L N + P P SLE L L N +
Sbjct: 443 ------------FLLRVPHLQILILNQNRFSSCSGDQTPSENP-SLEQLFLGENMLQLAW 489
Query: 233 -VKLAPEDLANLTALRVLDVGGNCRRCDHAPNPCMECPRHFPQLHPDTFSHLSRLEGLVL 291
+L + L+ L+VL + N + L P FSHL+ L GL L
Sbjct: 490 ETELCWDVFEGLSHLQVLYLNHN----------------YLNSLPPGVFSHLTALRGLSL 533
Query: 292 KDSSLSWLNASWFRGLGNLRVLDLSENFL 320
+ L+ L+ + NL +LD+S N L
Sbjct: 534 NSNRLTVLSHNDLP--ANLEILDISRNQL 560
Score = 43.9 bits (102), Expect = 8e-04
Identities = 68/279 (24%), Positives = 108/279 (38%), Gaps = 79/279 (28%)
Query: 65 VTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCPPVGLSPMHFPCHMTIEPSTFLAVPT 124
V + L N I + D F L L+ L+L+ N L+ +HF +P+
Sbjct: 362 VAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNA----LTTIHF-------------IPS 404
Query: 125 LEELNLSYNNIMTVPA--LPKSLISLS---------------LSHTNILMLDSASLAGLH 167
+ ++ LS N ++T+P L +LI LS + H IL+L+ +
Sbjct: 405 IPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCS 464
Query: 168 ---------ALRFLFMDGN----CYYKNPCRQALE-----------------VAPGALLG 197
+L LF+ N + C E + PG
Sbjct: 465 GDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSH 524
Query: 198 LGNLTHLSLKYNNLTVVPRN-LPSSLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGNCR 256
L L LSL N LTV+ N LP++LE L +S N+++ P+ +L+ VLD+ N
Sbjct: 525 LTALRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLAPNPDVFVSLS---VLDITHNKF 581
Query: 257 RCD-----------HAPNPCMECPRHFPQLHPDTFSHLS 284
C+ H P ++PD+FS +S
Sbjct: 582 ICECELSTFINWLNHTNVTIAGPPADIYCVYPDSFSGVS 620
Score = 40.4 bits (93), Expect = 0.009
Identities = 81/312 (25%), Positives = 121/312 (38%), Gaps = 42/312 (13%)
Query: 55 HFSMAAPRGNVTSLSLSSNRI------HHLHDSD---FAHLP--SLRHLNLKWNCPPVGL 103
+FS A + SL L+ + + H++ D D FA L S+RHL+L
Sbjct: 245 NFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFV---- 300
Query: 104 SPMHFPCHMTIEPSTFLAVPTLEELNLSYNNIMTVPALPKSLISLSLSHTNILMLDSASL 163
++ F + L+ LNL+YN I + L + +L L L
Sbjct: 301 --------FSLNSRVFETLKDLKVLNLAYNKINKIA----DEAFYGLDNLQVLNLSYNLL 348
Query: 164 AGLHALRFLFMDGNCYYKNPCRQALEVAPGALLGLGNLTHLSLKYNNLTVVPRNLPSSLE 223
L++ F + Y + L L L L+ N LT + + S+
Sbjct: 349 GELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTI--HFIPSIP 406
Query: 224 YLLLSYNRIVKLAPEDL-ANL-----TALRVLDVGGNCRRCDHAPNPCMECPRHFPQLHP 277
+ LS N++V L +L ANL L LD+ R H + R
Sbjct: 407 DIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGD 466
Query: 278 DTFSHLSRLEGLVLKDS--SLSW-LNASW--FRGLGNLRVLDLSENFLYKCITKTKAFQG 332
T S LE L L ++ L+W W F GL +L+VL L+ N+L F
Sbjct: 467 QTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNS--LPPGVFSH 524
Query: 333 LTQLRKLNLSFN 344
LT LR L+L+ N
Sbjct: 525 LTALRGLSLNSN 536
>gi|225579152 insulin-like growth factor binding protein, acid
labile subunit isoform 1 precursor [Homo sapiens]
Length = 643
Score = 147 bits (371), Expect = 5e-35
Identities = 178/617 (28%), Positives = 251/617 (40%), Gaps = 111/617 (17%)
Query: 210 NLTVVPRNLPSSLEYLLLSYNRIVKLAPEDLANLTALRVLDV-GGNCRRCDHAPNPCME- 267
NLT +P +P + L L N + + P NL++L L++ GG + +E
Sbjct: 102 NLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLEN 161
Query: 268 -CPRHFPQ-----LHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSENFLY 321
C H + L TF+H L L L ++ LS L F GLG+L L+L N L
Sbjct: 162 LCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSL- 220
Query: 322 KCITKTKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSFGSLVALKELDMHGIFFRSLDE 381
+ AF+GL LR+L L+ N R+++ +L F L L+ELD+ R++
Sbjct: 221 -AVLPDAAFRGLGSLRELVLAGN---RLAYLQPAL---FSGLAELRELDLSRNALRAIKA 273
Query: 382 TTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYVDLSDNRISGASELTATMGEAD 441
+LP LQ L L N I G F LR++DLS NR++G E T
Sbjct: 274 NVF---VQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTF------ 324
Query: 442 GGEKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLSRNNLVTVQPEMFAQLSHLQCL 501
PG L L LS N + +++P F L L+ L
Sbjct: 325 --------PGLLGLR-------------------VLRLSHNAIASLRPRTFKDLHFLEEL 357
Query: 502 RLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEALDLSYNSQPFGM 561
+L HN I Q S F L L+VL L HN+L +F L + ++LS N
Sbjct: 358 QLGHNRIRQLAERS-FEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGN------ 410
Query: 562 QGVGHNFSFVAHLRTLRHLSLAHNNIHSQVSQQLCSTSLRALDFSGNALGHMWAEGDLYL 621
N+ QV + L L +L G+ LG +
Sbjct: 411 ---------------------CLRNLPEQVFRGL--GKLHSLHLEGSCLGR------IRP 441
Query: 622 HFFQGLSGLIWLDLSQNRLHTLLPQTLRNLPKSLQVLRLRDNYLAFFKWWSLHFLPKLEV 681
H F GLSGL L L N L + Q+L L + L+ L L N L L KLE
Sbjct: 442 HTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLE-LDLTSNQLTHLPHRLFQGLGKLEY 500
Query: 682 LDLAGNQLKALTNGSLPAGTRLRRLDVSCNSISFVAPGFFSKAKELRELNLSANALKTVD 741
L L+ N+L L +L R LDVS N + + + LR L+L N+L+T
Sbjct: 501 LLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRT-- 558
Query: 742 HSWFGPLASALQILDVSANPLHCACG-AAFMDFLLEVQAAVPGLP--------------- 785
F P L+ L + NP C C A DF L+ +AVP
Sbjct: 559 ---FTPQPPGLERLWLEGNPWDCGCPLKALRDFALQNPSAVPRFVQAICEGDDCQPPAYT 615
Query: 786 -SRVKCGSPGQLQGLSI 801
+ + C SP ++ GL +
Sbjct: 616 YNNITCASPPEVVGLDL 632
Score = 103 bits (258), Expect = 6e-22
Identities = 144/545 (26%), Positives = 205/545 (37%), Gaps = 139/545 (25%)
Query: 65 VTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCPPVGLSPMHFPCHMTIEPSTFLAVPT 124
+ SL LS+NR+ L D F L SL LNL WN V + + F + +
Sbjct: 186 LASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAV------------LPDAAFRGLGS 233
Query: 125 LEELNLSYNNIMTV-PALPKSLI---SLSLSHTNILMLDSASLAGLHALRFLFMDGNCYY 180
L EL L+ N + + PAL L L LS + + + L L+ L++D N
Sbjct: 234 LRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNL-- 291
Query: 181 KNPCRQALEVAPGALLGLGNLTHLSLKYNNLTVVPRNLPSSLEYLLLSYNRIVKLAPEDL 240
VAPGA LGL +L +L LS+NR+ L +
Sbjct: 292 ------IAAVAPGAFLGL---------------------KALRWLDLSHNRVAGLLEDTF 324
Query: 241 ANLTALRVLDVGGNCRRCDHAPNPCMECPRHFPQLHPDTFSHLSRLEGLVLKDSSLSWLN 300
L LRVL + N L P TF L LE L L + + L
Sbjct: 325 PGLLGLRVLRLSHNA----------------IASLRPRTFKDLHFLEELQLGHNRIRQLA 368
Query: 301 ASWFRGLGNLRVLDLSENFLYKCITKTKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSF 360
F GLG L VL L N L + K AF GLT + +NLS
Sbjct: 369 ERSFEGLGQLEVLTLDHNQLQE--VKAGAFLGLTNVAVMNLS------------------ 408
Query: 361 GSLVALKELDMHGIFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYV 420
G R+L E R L + L +L L+ + + + + F GLR +
Sbjct: 409 ------------GNCLRNLPEQVFRGLGK---LHSLHLEGSCLGRIRPHTFTGLSGLRRL 453
Query: 421 DLSDNRISGASELTATMGEADGGEKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLS 480
L DN + G E + +W LA LDL+
Sbjct: 454 FLKDNGLVGIEE-----------QSLW----GLAEL------------------LELDLT 480
Query: 481 RNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHS 540
N L + +F L L+ L LS N +++ + PL LD+SHN+L+
Sbjct: 481 SNQLTHLPHRLFQGLGKLEYLLLSRNRLAE-LPADALGPLQRAFWLDVSHNRLEALPNSL 539
Query: 541 FTELPRLEALDLSYNS------QPFGMQGV---GHNFSFVAHLRTLRHLSLAHNNIHSQV 591
L RL L L NS QP G++ + G+ + L+ LR +L + + +
Sbjct: 540 LAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLKALRDFALQNPSAVPRF 599
Query: 592 SQQLC 596
Q +C
Sbjct: 600 VQAIC 604
Score = 94.0 bits (232), Expect = 7e-19
Identities = 161/580 (27%), Positives = 224/580 (38%), Gaps = 101/580 (17%)
Query: 131 SYNNIMTVP-ALPKSLISLSLSHTNILMLDSASLAGLHALRFLFMDGNCYYKNPCRQALE 189
S N+ +P +P +L L N+ + A+ L +L FL + G Q
Sbjct: 99 SSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGG--------QLGS 150
Query: 190 VAPGALLGLGNLTHLSLKYNNLTVVPRNL---PSSLEYLLLSYNRIVKLAPEDLANLTAL 246
+ P ALLGL NL HL L+ N L + +L L LS NR+ +L L +L
Sbjct: 151 LEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSL 210
Query: 247 RVLDVGGNCRRCDHAPNPCMECPRHFPQLHPDTFSHLSRLEGLVLKDSSLSWLNASWFRG 306
L++G N L F L L LVL + L++L + F G
Sbjct: 211 WDLNLGWN----------------SLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSG 254
Query: 307 LGNLRVLDLSENFLYKCITKTKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSFGSLVAL 366
L LR LDLS N L K F L +L+KL L N V+ +F L AL
Sbjct: 255 LAELRELDLSRNALR--AIKANVFVQLPRLQKLYLDRNLIAAVA------PGAFLGLKAL 306
Query: 367 KELDMHGIFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYVDLSDNR 426
+ LD+ L E T L L+ LRL N I + F+ L + L NR
Sbjct: 307 RWLDLSHNRVAGLLEDTFPGLLG---LRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNR 363
Query: 427 ISGASELTATMGEADGGEKVWLQPGDLAPAPVDTPSSEDFRPNC---STLNFTLDLSRNN 483
I + E+ + G L +D ++ + T ++LS N
Sbjct: 364 IRQLA------------ERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNC 411
Query: 484 LVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHSFTE 543
L + ++F L L L L +C+ + + F L+GL+ L L N L E S
Sbjct: 412 LRNLPEQVFRGLGKLHSLHLEGSCLGR-IRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWG 470
Query: 544 LPRLEALDLSYNSQPFGMQGVGHNFSFVAHLRTLRHLSLAHNNIHSQVSQQLCSTSLRAL 603
L L LDL+ N + + H L L +L L+ N R
Sbjct: 471 LAELLELDLTSNQ----LTHLPHR--LFQGLGKLEYLLLSRN---------------RLA 509
Query: 604 DFSGNALGHMWAEGDLYLHFFQGLSGLIWLDLSQNRLHTLLPQTLRNLPKSLQVLRLRDN 663
+ +ALG L WLD+S NRL LP +L L+ L LR+N
Sbjct: 510 ELPADALG--------------PLQRAFWLDVSHNRLEA-LPNSLLAPLGRLRYLSLRNN 554
Query: 664 YLAFFKWWSLHFLPKLEVLDLAGN------QLKALTNGSL 697
L F P LE L L GN LKAL + +L
Sbjct: 555 SLRTFTPQP----PGLERLWLEGNPWDCGCPLKALRDFAL 590
Score = 44.7 bits (104), Expect = 5e-04
Identities = 53/201 (26%), Positives = 79/201 (39%), Gaps = 35/201 (17%)
Query: 63 GNVTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNC----PPV---GLSPMHF-----PC 110
G + L+L N++ + F L ++ +NL NC P GL +H C
Sbjct: 376 GQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSC 435
Query: 111 HMTIEPSTFLAVPTLEELNLSYNNIMTVPALP----KSLISLSLSHTNILMLDSASLAGL 166
I P TF + L L L N ++ + L+ L L+ + L GL
Sbjct: 436 LGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGL 495
Query: 167 HALRFLFMDGN---------------CYYKNPCRQALEVAPGALLG-LGNLTHLSLKYNN 210
L +L + N ++ + LE P +LL LG L +LSL+ N+
Sbjct: 496 GKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNS 555
Query: 211 L-TVVPRNLPSSLEYLLLSYN 230
L T P+ P LE L L N
Sbjct: 556 LRTFTPQ--PPGLERLWLEGN 574
>gi|4826772 insulin-like growth factor binding protein, acid labile
subunit isoform 2 precursor [Homo sapiens]
Length = 605
Score = 147 bits (371), Expect = 5e-35
Identities = 178/617 (28%), Positives = 251/617 (40%), Gaps = 111/617 (17%)
Query: 210 NLTVVPRNLPSSLEYLLLSYNRIVKLAPEDLANLTALRVLDV-GGNCRRCDHAPNPCME- 267
NLT +P +P + L L N + + P NL++L L++ GG + +E
Sbjct: 64 NLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLEN 123
Query: 268 -CPRHFPQ-----LHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSENFLY 321
C H + L TF+H L L L ++ LS L F GLG+L L+L N L
Sbjct: 124 LCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSL- 182
Query: 322 KCITKTKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSFGSLVALKELDMHGIFFRSLDE 381
+ AF+GL LR+L L+ N R+++ +L F L L+ELD+ R++
Sbjct: 183 -AVLPDAAFRGLGSLRELVLAGN---RLAYLQPAL---FSGLAELRELDLSRNALRAIKA 235
Query: 382 TTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYVDLSDNRISGASELTATMGEAD 441
+LP LQ L L N I G F LR++DLS NR++G E T
Sbjct: 236 NVF---VQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTF------ 286
Query: 442 GGEKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLSRNNLVTVQPEMFAQLSHLQCL 501
PG L L LS N + +++P F L L+ L
Sbjct: 287 --------PGLLGLR-------------------VLRLSHNAIASLRPRTFKDLHFLEEL 319
Query: 502 RLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEALDLSYNSQPFGM 561
+L HN I Q S F L L+VL L HN+L +F L + ++LS N
Sbjct: 320 QLGHNRIRQLAERS-FEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGN------ 372
Query: 562 QGVGHNFSFVAHLRTLRHLSLAHNNIHSQVSQQLCSTSLRALDFSGNALGHMWAEGDLYL 621
N+ QV + L L +L G+ LG +
Sbjct: 373 ---------------------CLRNLPEQVFRGL--GKLHSLHLEGSCLGR------IRP 403
Query: 622 HFFQGLSGLIWLDLSQNRLHTLLPQTLRNLPKSLQVLRLRDNYLAFFKWWSLHFLPKLEV 681
H F GLSGL L L N L + Q+L L + L+ L L N L L KLE
Sbjct: 404 HTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLE-LDLTSNQLTHLPHRLFQGLGKLEY 462
Query: 682 LDLAGNQLKALTNGSLPAGTRLRRLDVSCNSISFVAPGFFSKAKELRELNLSANALKTVD 741
L L+ N+L L +L R LDVS N + + + LR L+L N+L+T
Sbjct: 463 LLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRT-- 520
Query: 742 HSWFGPLASALQILDVSANPLHCACG-AAFMDFLLEVQAAVPGLP--------------- 785
F P L+ L + NP C C A DF L+ +AVP
Sbjct: 521 ---FTPQPPGLERLWLEGNPWDCGCPLKALRDFALQNPSAVPRFVQAICEGDDCQPPAYT 577
Query: 786 -SRVKCGSPGQLQGLSI 801
+ + C SP ++ GL +
Sbjct: 578 YNNITCASPPEVVGLDL 594
Score = 103 bits (258), Expect = 6e-22
Identities = 144/545 (26%), Positives = 205/545 (37%), Gaps = 139/545 (25%)
Query: 65 VTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCPPVGLSPMHFPCHMTIEPSTFLAVPT 124
+ SL LS+NR+ L D F L SL LNL WN V + + F + +
Sbjct: 148 LASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAV------------LPDAAFRGLGS 195
Query: 125 LEELNLSYNNIMTV-PALPKSLI---SLSLSHTNILMLDSASLAGLHALRFLFMDGNCYY 180
L EL L+ N + + PAL L L LS + + + L L+ L++D N
Sbjct: 196 LRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNL-- 253
Query: 181 KNPCRQALEVAPGALLGLGNLTHLSLKYNNLTVVPRNLPSSLEYLLLSYNRIVKLAPEDL 240
VAPGA LGL +L +L LS+NR+ L +
Sbjct: 254 ------IAAVAPGAFLGL---------------------KALRWLDLSHNRVAGLLEDTF 286
Query: 241 ANLTALRVLDVGGNCRRCDHAPNPCMECPRHFPQLHPDTFSHLSRLEGLVLKDSSLSWLN 300
L LRVL + N L P TF L LE L L + + L
Sbjct: 287 PGLLGLRVLRLSHNA----------------IASLRPRTFKDLHFLEELQLGHNRIRQLA 330
Query: 301 ASWFRGLGNLRVLDLSENFLYKCITKTKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSF 360
F GLG L VL L N L + K AF GLT + +NLS
Sbjct: 331 ERSFEGLGQLEVLTLDHNQLQE--VKAGAFLGLTNVAVMNLS------------------ 370
Query: 361 GSLVALKELDMHGIFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYV 420
G R+L E R L + L +L L+ + + + + F GLR +
Sbjct: 371 ------------GNCLRNLPEQVFRGLGK---LHSLHLEGSCLGRIRPHTFTGLSGLRRL 415
Query: 421 DLSDNRISGASELTATMGEADGGEKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLS 480
L DN + G E + +W LA LDL+
Sbjct: 416 FLKDNGLVGIEE-----------QSLW----GLAEL------------------LELDLT 442
Query: 481 RNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHS 540
N L + +F L L+ L LS N +++ + PL LD+SHN+L+
Sbjct: 443 SNQLTHLPHRLFQGLGKLEYLLLSRNRLAE-LPADALGPLQRAFWLDVSHNRLEALPNSL 501
Query: 541 FTELPRLEALDLSYNS------QPFGMQGV---GHNFSFVAHLRTLRHLSLAHNNIHSQV 591
L RL L L NS QP G++ + G+ + L+ LR +L + + +
Sbjct: 502 LAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLKALRDFALQNPSAVPRF 561
Query: 592 SQQLC 596
Q +C
Sbjct: 562 VQAIC 566
Score = 94.0 bits (232), Expect = 7e-19
Identities = 161/580 (27%), Positives = 224/580 (38%), Gaps = 101/580 (17%)
Query: 131 SYNNIMTVP-ALPKSLISLSLSHTNILMLDSASLAGLHALRFLFMDGNCYYKNPCRQALE 189
S N+ +P +P +L L N+ + A+ L +L FL + G Q
Sbjct: 61 SSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGG--------QLGS 112
Query: 190 VAPGALLGLGNLTHLSLKYNNLTVVPRNL---PSSLEYLLLSYNRIVKLAPEDLANLTAL 246
+ P ALLGL NL HL L+ N L + +L L LS NR+ +L L +L
Sbjct: 113 LEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSL 172
Query: 247 RVLDVGGNCRRCDHAPNPCMECPRHFPQLHPDTFSHLSRLEGLVLKDSSLSWLNASWFRG 306
L++G N L F L L LVL + L++L + F G
Sbjct: 173 WDLNLGWN----------------SLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSG 216
Query: 307 LGNLRVLDLSENFLYKCITKTKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSFGSLVAL 366
L LR LDLS N L K F L +L+KL L N V+ +F L AL
Sbjct: 217 LAELRELDLSRNALR--AIKANVFVQLPRLQKLYLDRNLIAAVA------PGAFLGLKAL 268
Query: 367 KELDMHGIFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYVDLSDNR 426
+ LD+ L E T L L+ LRL N I + F+ L + L NR
Sbjct: 269 RWLDLSHNRVAGLLEDTFPGLLG---LRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNR 325
Query: 427 ISGASELTATMGEADGGEKVWLQPGDLAPAPVDTPSSEDFRPNC---STLNFTLDLSRNN 483
I + E+ + G L +D ++ + T ++LS N
Sbjct: 326 IRQLA------------ERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNC 373
Query: 484 LVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHSFTE 543
L + ++F L L L L +C+ + + F L+GL+ L L N L E S
Sbjct: 374 LRNLPEQVFRGLGKLHSLHLEGSCLGR-IRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWG 432
Query: 544 LPRLEALDLSYNSQPFGMQGVGHNFSFVAHLRTLRHLSLAHNNIHSQVSQQLCSTSLRAL 603
L L LDL+ N + + H L L +L L+ N R
Sbjct: 433 LAELLELDLTSNQ----LTHLPHR--LFQGLGKLEYLLLSRN---------------RLA 471
Query: 604 DFSGNALGHMWAEGDLYLHFFQGLSGLIWLDLSQNRLHTLLPQTLRNLPKSLQVLRLRDN 663
+ +ALG L WLD+S NRL LP +L L+ L LR+N
Sbjct: 472 ELPADALG--------------PLQRAFWLDVSHNRLEA-LPNSLLAPLGRLRYLSLRNN 516
Query: 664 YLAFFKWWSLHFLPKLEVLDLAGN------QLKALTNGSL 697
L F P LE L L GN LKAL + +L
Sbjct: 517 SLRTFTPQP----PGLERLWLEGNPWDCGCPLKALRDFAL 552
Score = 44.7 bits (104), Expect = 5e-04
Identities = 53/201 (26%), Positives = 79/201 (39%), Gaps = 35/201 (17%)
Query: 63 GNVTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNC----PPV---GLSPMHF-----PC 110
G + L+L N++ + F L ++ +NL NC P GL +H C
Sbjct: 338 GQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSC 397
Query: 111 HMTIEPSTFLAVPTLEELNLSYNNIMTVPALP----KSLISLSLSHTNILMLDSASLAGL 166
I P TF + L L L N ++ + L+ L L+ + L GL
Sbjct: 398 LGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGL 457
Query: 167 HALRFLFMDGN---------------CYYKNPCRQALEVAPGALLG-LGNLTHLSLKYNN 210
L +L + N ++ + LE P +LL LG L +LSL+ N+
Sbjct: 458 GKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNS 517
Query: 211 L-TVVPRNLPSSLEYLLLSYN 230
L T P+ P LE L L N
Sbjct: 518 LRTFTPQ--PPGLERLWLEGN 536
>gi|19924149 toll-like receptor 4 precursor [Homo sapiens]
Length = 839
Score = 139 bits (350), Expect = 1e-32
Identities = 229/909 (25%), Positives = 382/909 (42%), Gaps = 146/909 (16%)
Query: 157 MLDSASLAG--LHALRFLFMDGNCYYKNPCRQALEVAPGALLGLGNLTHLSLKYNNLTVV 214
M+ ++ LAG + A+ FL +C +EV P N+T+ ++ N +
Sbjct: 1 MMSASRLAGTLIPAMAFL----SCVRPESWEPCVEVVP-------NITYQCMELN-FYKI 48
Query: 215 PRNLPSSLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGNCRRCDHAPNPCMECPRHFPQ 274
P NLP S + L LS+N + L + L+VLD+ RC+
Sbjct: 49 PDNLPFSTKNLDLSFNPLRHLGSYSFFSFPELQVLDLS----RCE------------IQT 92
Query: 275 LHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSENFLYKCITKTKAFQGLT 334
+ + LS L L+L + + L F GL +L+ L E L + L
Sbjct: 93 IEDGAYQSLSHLSTLILTGNPIQSLALGAFSGLSSLQKLVAVETNLASL--ENFPIGHLK 150
Query: 335 QLRKLNLSFNYQKRVSFAHLSLAPSFGSLVALKELDMHGIFFRSLDETTLRPLARLPMLQ 394
L++LN++ N L F +L L+ LD+ +S+ T LR L ++P+L
Sbjct: 151 TLKELNVAHNL-----IQSFKLPEYFSNLTNLEHLDLSSNKIQSIYCTDLRVLHQMPLLN 205
Query: 395 -TLRLQMNFINQAQLGIFRA-----------FPGLRYVDLSDNRISGASELTATMGEADG 442
+L L +N +N Q G F+ F L + ++G +GE
Sbjct: 206 LSLDLSLNPMNFIQPGAFKEIRLHKLTLRNNFDSLNVMKTCIQGLAGLEVHRLVLGE--- 262
Query: 443 GEKVWLQPGDL------APAPVDTPSSEDFRPNCSTLNFTLD-----------LSRNNLV 485
+ G+L A + + E+FR + L++ LD +S +LV
Sbjct: 263 ----FRNEGNLEKFDKSALEGLCNLTIEEFR--LAYLDYYLDDIIDLFNCLTNVSSFSLV 316
Query: 486 TVQPEMFAQLSH---LQCLRLSHNCISQAVNGSQF--LPLTGLQVLDLSHNKLDLYHEHS 540
+V E S+ Q L L NC QF L L L+ L + NK + S
Sbjct: 317 SVTIERVKDFSYNFGWQHLELV-NC-----KFGQFPTLKLKSLKRLTFTSNKGG--NAFS 368
Query: 541 FTELPRLEALDLSYNSQPFGMQGVGHNFSFVAHLRTLRHLSLAHNNIHSQVSQQLCSTSL 600
+LP LE LDLS N F +G F +L++L L+ N + + S L L
Sbjct: 369 EVDLPSLEFLDLSRNGLSF--KGCCSQSDFGT--TSLKYLDLSFNGVITMSSNFLGLEQL 424
Query: 601 RALDFSGNALGHMWAEGDLYLHFFQGLSGLIWLDLSQNRLHTLLPQTLRNLPKSLQVLRL 660
LDF + L M +E ++L L LI+LD+S L SL+VL++
Sbjct: 425 EHLDFQHSNLKQM-SEFSVFL----SLRNLIYLDISHTHTRVAFNGIFNGL-SSLEVLKM 478
Query: 661 RDNYLAFFKWWSLHFLP-------KLEVLDLAGNQLKALTNGSLPAGTRLRRLDVSCNSI 713
N + +FLP L LDL+ QL+ L+ + + + L+ L++S N+
Sbjct: 479 AGNS------FQENFLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNF 532
Query: 714 SFVAPGFFSKAKELRELNLSANALKTVDHSWFGPLASALQILDVSANPLHCACG-AAFMD 772
+ + L+ L+ S N + T S+L L+++ N C C +F+
Sbjct: 533 FSLDTFPYKCLNSLQVLDYSLNHIMTSKKQELQHFPSSLAFLNLTQNDFACTCEHQSFLQ 592
Query: 773 FLLEVQAAVPGLPSRVKCGSPGQLQGLSIFAQDLRLCLDEALSWDCFALSLLAVALGLGV 832
++ + + + + R++C +P QG+ + + ++ +++ + +S+L+V + V
Sbjct: 593 WIKDQRQLLVEV-ERMECATPSDKQGMPVLSLNITCQMNKTI----IGVSVLSVLVVSVV 647
Query: 833 PMLHHLCGWDLWYCFHL-----CLAWLPWRGRQSGRDEDALPYDAFVVFDKTQSAVADWV 887
+L + + FHL C+ + GR E+ YDAFV++ DWV
Sbjct: 648 AVLVYK------FYFHLMLLAGCIKY--------GRGENI--YDAFVIYSSQDE---DWV 688
Query: 888 YNELRGQLEECRGRWALRLCLEERDWLPGKTLFENL-WASVYGSRKTLFVLAHTDRVSGL 946
NEL LEE G +LCL RD++PG + N+ + SRK + V++ S
Sbjct: 689 RNELVKNLEE--GVPPFQLCLHYRDFIPGVAIAANIIHEGFHKSRKVIVVVSQHFIQSRW 746
Query: 947 LRASFLLAQQ-RLLEDRKDVVVLVILSPDGRRSRY-VRLRQRLCRQSVLLWPHQPSGQRS 1004
+ +AQ + L R ++ +V+ + R V L + L R + L W G+
Sbjct: 747 CIFEYEIAQTWQFLSSRAGIIFIVLQKVEKTLLRQQVELYRLLSRNTYLEWEDSVLGRHI 806
Query: 1005 FWAQLGMAL 1013
FW +L AL
Sbjct: 807 FWRRLRKAL 815
Score = 53.1 bits (126), Expect = 1e-06
Identities = 70/258 (27%), Positives = 107/258 (41%), Gaps = 52/258 (20%)
Query: 42 LVNCNW-----LFLKSVPHFSMAAPRG----------NVTSLSLSSNRIHH---LHDSDF 83
LVNC + L LKS+ + + +G ++ L LS N + SDF
Sbjct: 337 LVNCKFGQFPTLKLKSLKRLTFTSNKGGNAFSEVDLPSLEFLDLSRNGLSFKGCCSQSDF 396
Query: 84 AHLPSLRHLNLKWNCPPVGLSPMHFPCHMTIEPSTFLAVPTLEELNLSYNNIMTVPALP- 142
SL++L+L +N G+ M S FL + LE L+ ++N+ +
Sbjct: 397 G-TTSLKYLDLSFN----GVITMS---------SNFLGLEQLEHLDFQHSNLKQMSEFSV 442
Query: 143 ----KSLISLSLSHTNILMLDSASLAGLHALRFLFMDGNCYYKNPCRQALEVAPGALLGL 198
++LI L +SHT+ + + GL +L L M GN + +N P L
Sbjct: 443 FLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQEN-------FLPDIFTEL 495
Query: 199 GNLTHLSL---KYNNLTVVPRNLPSSLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGNC 255
NLT L L + L+ N SSL+ L +S+N L L +L+VLD N
Sbjct: 496 RNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYKCLNSLQVLDYSLN- 554
Query: 256 RRCDHAPNPCMECPRHFP 273
H + +HFP
Sbjct: 555 ----HIMTSKKQELQHFP 568
>gi|19718734 toll-like receptor 2 [Homo sapiens]
Length = 784
Score = 128 bits (322), Expect = 2e-29
Identities = 127/457 (27%), Positives = 213/457 (46%), Gaps = 48/457 (10%)
Query: 573 HLRTLRHLSLAHN-NIHSQVSQQLCST---SLRALDFSGNALGHMWAEGDLYLHFFQGLS 628
HL++L +L L+ N + + C SL+ L N L + G+ L L
Sbjct: 358 HLKSLEYLDLSENLMVEEYLKNSACEDAWPSLQTLILRQNHLASLEKTGETLLT----LK 413
Query: 629 GLIWLDLSQNRLHTLLPQTLRNLPKSLQVLRLRDNYLAFFKWWSLHFLPK-LEVLDLAGN 687
L +D+S+N H++ P+T + P+ ++ L L + +PK LE+LD++ N
Sbjct: 414 NLTNIDISKNSFHSM-PETCQ-WPEKMKYLNLSSTRIHSVTGC----IPKTLEILDVSNN 467
Query: 688 QLKALTNGSLPAGTRLRRLDVSCNSISFVAPGFFSKAKELRELNLSANALKTVDHSWFGP 747
L L + +LP +L+ L +S N + + S L L +S NA+ T
Sbjct: 468 NLN-LFSLNLP---QLKELYISRNKLMTLPDA--SLLPMLLVLKISRNAITTFSKEQLDS 521
Query: 748 LASALQILDVSANPLHCACGAAFMDFLLEVQAAVPGL---PSRVKCGSPGQLQGLSIFAQ 804
+ L+ L+ N C+C F+ F E QA L P+ C SP ++G + Q
Sbjct: 522 FHT-LKTLEAGGNNFICSC--EFLSFTQEQQALAKVLIDWPANYLCDSPSHVRGQQV--Q 576
Query: 805 DLRLCLDEA-----LSWDCFALSLLAVALGLGVPMLHHLCGWDLWYCFHLCLAWLPWRGR 859
D+RL + E +S C AL LL + G+ + H G LWY + AWL + +
Sbjct: 577 DVRLSVSECHRTALVSGMCCALFLLILLTGV---LCHRFHG--LWY-MKMMWAWLQAKRK 630
Query: 860 QSGRDEDALPYDAFVVFDKTQSAVADWVYNELRGQLEECRGRWALRLCLEERDWLPGKTL 919
+ YDAFV + + A WV N + +LE + +LCL +RD++PGK +
Sbjct: 631 PRKAPSRNICYDAFVSYSERD---AYWVENLMVQELENFNPPF--KLCLHKRDFIPGKWI 685
Query: 920 FENLWASVYGSRKTLFVLAHTDRVSGLLRASFLLAQQRLLEDRKDVVVLVILSPDGRRS- 978
+N+ S+ S KT+FVL+ S + + RL ++ D +L++L P +++
Sbjct: 686 IDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFSHFRLFDENNDAAILILLEPIEKKAI 745
Query: 979 --RYVRLRQRLCRQSVLLWPHQPSGQRSFWAQLGMAL 1013
R+ +LR+ + ++ L WP + + FW L A+
Sbjct: 746 PQRFCKLRKIMNTKTYLEWPMDEAQREGFWVNLRAAI 782
Score = 54.7 bits (130), Expect = 4e-07
Identities = 133/541 (24%), Positives = 206/541 (38%), Gaps = 112/541 (20%)
Query: 210 NLTVVPRNLPSSLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGNCRRCDHAPNPCMECP 269
+L +P L +++ L LS NRI ++ DL L+ L + N
Sbjct: 42 SLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSN--------------- 86
Query: 270 RHFPQLHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSENFLYKCITKTKA 329
+ D+FS L LE L L + LS L++SWF+ L +L L+L N YK + +T
Sbjct: 87 -GINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGN-PYKTLGETSL 144
Query: 330 FQGLTQLRKLNL----SFNYQKRVSFAHLSLAPSFGSLVALKELDMHGIFFRSLDETTLR 385
F LT+L+ L + +F +R FA L+ L+EL++ +S + +L+
Sbjct: 145 FSHLTKLQILRVGNMDTFTKIQRKDFAGLTF---------LEELEIDASDLQSYEPKSLK 195
Query: 386 PLAR-----LPMLQTLRLQMNFIN-----------QAQLGIFR----------------A 413
+ L M Q + L F++ L F
Sbjct: 196 SIQNVSHLILHMKQHILLLEIFVDVTSSVECLELRDTDLDTFHFSELSTGETNSLIKKFT 255
Query: 414 FPGLRYVDLS-------DNRISGASELTATMGEADGGEKVWLQPGD--LAPAPVDT---- 460
F ++ D S N+ISG EL +G D + P V+T
Sbjct: 256 FRNVKITDESLFQVMKLLNQISGLLELEFDDCTLNGVGNFRASDNDRVIDPGKVETLTIR 315
Query: 461 ----PSSEDFRPNCSTLNFTLDLSR----NNLVTVQPEMFAQ-LSHLQCLRLSHNCISQA 511
P F + + T + R N+ V + P + +Q L L+ L LS N + +
Sbjct: 316 RLHIPRFYLFYDLSTLYSLTERVKRITVENSKVFLVPCLLSQHLKSLEYLDLSENLMVEE 375
Query: 512 V--NGSQFLPLTGLQVLDLSHNKLDLYHE--HSFTELPRLEALDLSYNSQPFGMQGVGHN 567
N + LQ L L N L + + L L +D+S NS H+
Sbjct: 376 YLKNSACEDAWPSLQTLILRQNHLASLEKTGETLLTLKNLTNIDISKNS--------FHS 427
Query: 568 FSFVAHL-RTLRHLSLAHNNIHSQVSQQLCSTSLRALDFSGNALGHMWAEGDLYLHFFQG 626
+++L+L+ IHS +L LD S N L F
Sbjct: 428 MPETCQWPEKMKYLNLSSTRIHSVTG--CIPKTLEILDVSNNNLN----------LFSLN 475
Query: 627 LSGLIWLDLSQNRLHTLLPQTLRNLPKSLQVLRLRDNYLAFFKWWSLHFLPKLEVLDLAG 686
L L L +S+N+L TL +L LP L VL++ N + F L L+ L+ G
Sbjct: 476 LPQLKELYISRNKLMTLPDASL--LP-MLLVLKISRNAITTFSKEQLDSFHTLKTLEAGG 532
Query: 687 N 687
N
Sbjct: 533 N 533
Score = 49.3 bits (116), Expect = 2e-05
Identities = 30/97 (30%), Positives = 48/97 (49%), Gaps = 1/97 (1%)
Query: 682 LDLAGNQLKALTNGSLPAGTRLRRLDVSCNSISFVAPGFFSKAKELRELNLSANALKTVD 741
LDL+ N++ ++N L L+ L ++ N I+ + FS L L+LS N L +
Sbjct: 57 LDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLS 116
Query: 742 HSWFGPLASALQILDVSANPLHCACGAAFMDFLLEVQ 778
SWF PL S+L L++ NP + L ++Q
Sbjct: 117 SSWFKPL-SSLTFLNLLGNPYKTLGETSLFSHLTKLQ 152
Score = 39.7 bits (91), Expect = 0.015
Identities = 132/568 (23%), Positives = 224/568 (39%), Gaps = 112/568 (19%)
Query: 65 VTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCPPVGLSPMHFPCHMTIEPSTFLAVPT 124
V SL LS+NRI ++ +SD +L+ L L N G++ TIE +F ++ +
Sbjct: 54 VKSLDLSNNRITYISNSDLQRCVNLQALVLTSN----GIN--------TIEEDSFSSLGS 101
Query: 125 LEELNLSYNNIMTVPALPKSLISLSLSHTNILMLDSASLAGLHALRFLFMDGNCYYKNPC 184
LE L+LSYN + L S+ L +L FL + GN
Sbjct: 102 LEHLDLSYNYLSN--------------------LSSSWFKPLSSLTFLNLLGN------- 134
Query: 185 RQALEVAPGALLGLGNLTHLSLKYNNLTVVPRNLPSSLEYLLL-SYNRIVKLAPEDLANL 243
P LG +L +++LT L+ L + + + K+ +D A L
Sbjct: 135 -------PYKTLGETSL------FSHLT--------KLQILRVGNMDTFTKIQRKDFAGL 173
Query: 244 TALRVLDVGG---------NCRRCDHAPNPCMECPRHFPQLHPDTFSHL-SRLEGLVLKD 293
T L L++ + + + + + +H L + F + S +E L L+D
Sbjct: 174 TFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLL--EIFVDVTSSVECLELRD 231
Query: 294 SSLSWLNASWF-RGLGN-------LRVLDLSENFLYKCITKTKAFQGLTQLRKLNLSFN- 344
+ L + S G N R + +++ L++ + GL +L + + N
Sbjct: 232 TDLDTFHFSELSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQISGLLELEFDDCTLNG 291
Query: 345 -YQKRVSFAHLSLAPSFGSLVALKELDMHGIFFRSLDETTLRPLARLPMLQTLRLQMNFI 403
R S + P + ++ L + F+ D +TL L T+ F+
Sbjct: 292 VGNFRASDNDRVIDPGKVETLTIRRLHIPR-FYLFYDLSTLYSLTERVKRITVENSKVFL 350
Query: 404 NQAQLGIFRAFPGLRYVDLSDNRISGASELTATMGEADGGEKVWLQPGDLAPAPVDTPSS 463
L + L Y+DLS+N + + E W L S
Sbjct: 351 VPCLLS--QHLKSLEYLDLSENL------MVEEYLKNSACEDAWPSLQTLILRQNHLASL 402
Query: 464 EDFRPNCSTL-NFT-LDLSRNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSQFLPLT 521
E TL N T +D+S+N+ ++ PE ++ L LS I +V G +P T
Sbjct: 403 EKTGETLLTLKNLTNIDISKNSFHSM-PETCQWPEKMKYLNLSSTRI-HSVTGC--IPKT 458
Query: 522 GLQVLDLSHNKLDLYHEHSFTELPRLEALDLSYNSQPFGMQGVGHNFSFVAHLRTLRHLS 581
L++LD+S+N L+L+ LP+L+ L +S N + L L L
Sbjct: 459 -LEILDVSNNNLNLFS----LNLPQLKELYISRNKL--------MTLPDASLLPMLLVLK 505
Query: 582 LAHNNIHSQVSQQLCS-TSLRALDFSGN 608
++ N I + +QL S +L+ L+ GN
Sbjct: 506 ISRNAITTFSKEQLDSFHTLKTLEAGGN 533
Score = 39.3 bits (90), Expect = 0.019
Identities = 29/107 (27%), Positives = 48/107 (44%)
Query: 651 LPKSLQVLRLRDNYLAFFKWWSLHFLPKLEVLDLAGNQLKALTNGSLPAGTRLRRLDVSC 710
L ++++ L L +N + + L L+ L L N + + S + L LD+S
Sbjct: 50 LTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSY 109
Query: 711 NSISFVAPGFFSKAKELRELNLSANALKTVDHSWFGPLASALQILDV 757
N +S ++ +F L LNL N KT+ + + LQIL V
Sbjct: 110 NYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRV 156
Score = 32.0 bits (71), Expect = 3.1
Identities = 42/152 (27%), Positives = 62/152 (40%), Gaps = 32/152 (21%)
Query: 64 NVTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCPPVGLSPMHFPCHMTIEPSTFLAVP 123
N+ +L L+SN I+ + + F+ L SL HL+L +N LS + S F +
Sbjct: 77 NLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNY----LS--------NLSSSWFKPLS 124
Query: 124 TLEELNLSYNNIMTV--PALPKSLISLSL-------SHTNILMLDSASLAGLHALRFLFM 174
+L LNL N T+ +L L L + + T I D A L L L
Sbjct: 125 SLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGLTFLEELEIDAS 184
Query: 175 DGNCYYKNPCRQALEVAPGALLGLGNLTHLSL 206
D Y P +L + N++HL L
Sbjct: 185 DLQSY-----------EPKSLKSIQNVSHLIL 205
>gi|20143971 toll-like receptor 6 [Homo sapiens]
Length = 796
Score = 108 bits (270), Expect = 3e-23
Identities = 189/778 (24%), Positives = 328/778 (42%), Gaps = 96/778 (12%)
Query: 271 HFPQLHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSENFLYKCITKTKAF 330
+ +L S LS L L L + + L+ S F+ +L LDLS N L K +
Sbjct: 63 YIAELQVSDMSFLSELTVLRLSHNRIQLLDLSVFKFNQDLEYLDLSHNQLQKI-----SC 117
Query: 331 QGLTQLRKLNLSFNYQKRVSFAHLSLAPSFGSLVALKELDMHGIFFRSLDETTLRPLARL 390
+ R L+LSFN F L + FG+L L L + + + LD L P+A L
Sbjct: 118 HPIVSFRHLDLSFN-----DFKALPICKEFGNLSQLNFLGLSAMKLQKLD---LLPIAHL 169
Query: 391 PMLQTLRLQMNFI---NQAQ-LGIFRA-------FPGLRY---VDLSDNRISGASELTAT 436
+ L N+ N+ + L I A P + V++S N + G +LT
Sbjct: 170 HLSYILLDLRNYYIKENETESLQILNAKTLHLVFHPTSLFAIQVNISVNTL-GCLQLTNI 228
Query: 437 MGEADGGEKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLD-LSRNNLVTVQPEMFAQL 495
D + V + + LNFTL+ + V+ F
Sbjct: 229 KLNDDNCQ-------------VFIKFLSELTRGSTLLNFTLNHIETTWKCLVRVFQFLWP 275
Query: 496 SHLQCLRLSHNCISQAVNGSQFL-PLTGLQVLDLSH--NKLDLYHEHS-FTELPRLEALD 551
++ L + + I +++ F T L+ L + H N++ L+ + + +T + +
Sbjct: 276 KPVEYLNIYNLTIIESIREEDFTYSKTTLKALTIEHITNQVFLFSQTALYTVFSEMNIMM 335
Query: 552 LSYNSQPFGMQGVGHNFSFVAHLRTLRHLSLAHNNIHSQVSQQLCST--SLRALDFSGNA 609
L+ + PF H S T + L+ N + ++ CST L L N
Sbjct: 336 LTISDTPFIHMLCPHAPS------TFKFLNFTQNVFTDSIFEK-CSTLVKLETLILQKNG 388
Query: 610 LGHMWAEGDLYLHFFQGLSGLIWLDLSQNRLHTLLPQTLRNLPKSLQVLRLRDNYLAFFK 669
L ++ G + + + L LD+S N L + + +S+ VL L N L
Sbjct: 389 LKDLFKVGLMT----KDMPSLEILDVSWNSLESGRHKENCTWVESIVVLNLSSNMLTDSV 444
Query: 670 WWSLHFLPKLEVLDLAGNQLKALTNGSLPAGTRLRRLDVSCNSISFVAPGFFSKAKELRE 729
+ L P+++VLDL N++K++ + L+ L+V+ NS++ + PG S + L
Sbjct: 445 FRCLP--PRIKVLDLHSNKIKSVPKQVVKLEA-LQELNVAFNSLTDL-PGCGSFSS-LSV 499
Query: 730 LNLSANALKTVDHSWFGPLASALQILDVSANPLHCACGAA-FMDFLLEVQAAV-PGLPSR 787
L + N++ +F ++ + NP C C F+ + +V + V G P
Sbjct: 500 LIIDHNSVSHPSADFFQS-CQKMRSIKAGDNPFQCTCELREFVKNIDQVSSEVLEGWPDS 558
Query: 788 VKCGSPGQLQGLSIFAQDLRLCLDEALSWDCFALSLLAVALGLGVPMLH----HLCGW-D 842
KC P +G + D +S ++LL V +G + +L LC + D
Sbjct: 559 YKCDYPESYRGSPL--------KDFHMSELSCNITLLIVTIGATMLVLAVTVTSLCIYLD 610
Query: 843 L-WYCFHLCLAWLPWRGRQSGRDEDALP----YDAFVVFDKTQSAVADWVYNELRGQLEE 897
L WY +C W R R + L + AF+ + + SA WV +EL LE
Sbjct: 611 LPWYLRMVC-QWTQTRRRARNIPLEELQRNLQFHAFISYSEHDSA---WVKSELVPYLE- 665
Query: 898 CRGRWALRLCLEERDWLPGKTLFENLWASVYGSRKTLFVLAHTDRVSGLLRASFLLAQQR 957
+ +++CL ER+++PGK++ EN+ + S K++FVL+ S A
Sbjct: 666 ---KEDIQICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHN 722
Query: 958 LLEDRKDVVVLVILSPDGRRS---RYVRLRQRLCRQSVLLWPHQPSGQRSFWAQLGMA 1012
L + + ++L++L P + S +Y +L+ + +++ L WP + S + FWA + A
Sbjct: 723 LFHEGSNNLILILLEPIPQNSIPNKYHKLKALMTQRTYLQWPKEKSKRGLFWANIRAA 780
Score = 43.9 bits (102), Expect = 8e-04
Identities = 32/79 (40%), Positives = 42/79 (53%), Gaps = 4/79 (5%)
Query: 477 LDLSRNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLY 536
LD+S+N + +Q + LS L LRLSHN I Q ++ S F L+ LDLSHN+L
Sbjct: 57 LDMSQNYIAELQVSDMSFLSELTVLRLSHNRI-QLLDLSVFKFNQDLEYLDLSHNQLQKI 115
Query: 537 HEHSFTELPRLEALDLSYN 555
H LDLS+N
Sbjct: 116 SCHPIVS---FRHLDLSFN 131
Score = 37.4 bits (85), Expect = 0.074
Identities = 35/115 (30%), Positives = 54/115 (46%), Gaps = 5/115 (4%)
Query: 649 RNLPKSLQVLRLRDNYLAFFKWWSLHFLPKLEVLDLAGNQLKALTNGSLPAGTRLRRLDV 708
++LP +VL + NY+A + + FL +L VL L+ N+++ L L LD+
Sbjct: 48 KDLPLKTKVLDMSQNYIAELQVSDMSFLSELTVLRLSHNRIQLLDLSVFKFNQDLEYLDL 107
Query: 709 SCNSISFVAPGFFSKAKELRELNLSANALKTVD-HSWFGPLASALQILDVSANPL 762
S N + ++ R L+LS N K + FG L S L L +SA L
Sbjct: 108 SHNQLQKIS---CHPIVSFRHLDLSFNDFKALPICKEFGNL-SQLNFLGLSAMKL 158
Score = 33.9 bits (76), Expect = 0.81
Identities = 36/118 (30%), Positives = 51/118 (43%), Gaps = 15/118 (12%)
Query: 65 VTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWN-CPPVGLSPMHFPCHMTIEPSTFLAVP 123
+T L LS NRI L S F L +L+L N + P+ H+ + + F A+P
Sbjct: 78 LTVLRLSHNRIQLLDLSVFKFNQDLEYLDLSHNQLQKISCHPIVSFRHLDLSFNDFKALP 137
Query: 124 TLEEL-NLSYNNIMTVPALPKSLISLSLSHTNILMLDSASLAGLHALRFLFMDGNCYY 180
+E NLS N L LS + LD +A LH L ++ +D YY
Sbjct: 138 ICKEFGNLSQLNF------------LGLSAMKLQKLDLLPIAHLH-LSYILLDLRNYY 182
>gi|41350337 toll-like receptor 1 [Homo sapiens]
Length = 786
Score = 105 bits (262), Expect = 2e-22
Identities = 192/863 (22%), Positives = 344/863 (39%), Gaps = 178/863 (20%)
Query: 209 NNLTVVPRNLPSSLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGNCRRCDHAPNPCMEC 268
N L VP++L L +S N I +L D+ +L+ LR+
Sbjct: 34 NGLIHVPKDLSQKTTILNISQNYISELWTSDILSLSKLRI-------------------- 73
Query: 269 PRHFPQLHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSENFLYKCITKTK 328
L++ + + +L+ S F+ L LDLS N L K
Sbjct: 74 --------------------LIISHNRIQYLDISVFKFNQELEYLDLSHNKLVKI----- 108
Query: 329 AFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSFGSLVALKELDMHGIFFRSLDETTLRPLA 388
+ L+ L+LSFN +F L + FG++ LK L G+ L+++++ P+A
Sbjct: 109 SCHPTVNLKHLDLSFN-----AFDALPICKEFGNMSQLKFL---GLSTTHLEKSSVLPIA 160
Query: 389 RLPMLQTLRLQMNFINQAQLGIFRAFPGLRYVDLSDNRISGASELTATMGEADGGEKVWL 448
L + + L + L T GE + E L
Sbjct: 161 HLNISKVLLV----------------------------------LGETYGEKEDPE--GL 184
Query: 449 QPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLSRNNLVTVQPEMFAQLSHLQCLRLSHNC- 507
Q + + P++++F +F LD+S + + +LS+++C+ + C
Sbjct: 185 QDFNTESLHIVFPTNKEF-------HFILDVSVKTVANL------ELSNIKCVLEDNKCS 231
Query: 508 ---------------ISQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHSFTELP-RLEALD 551
+ +N + + +++L L + Y S +L +L+ D
Sbjct: 232 YFLSILAKLQTNPKLSNLTLNNIETTWNSFIRILQLVWHTTVWYFSISNVKLQGQLDFRD 291
Query: 552 LSYNSQPFGM----QGVGHNFSFVAH--LRTLRHLSLAHNNIH-SQVSQQLCSTSLRA-- 602
Y+ Q V F F ++++ + + +++ LC + +
Sbjct: 292 FDYSGTSLKALSIHQVVSDVFGFPQSYIYEIFSNMNIKNFTVSGTRMVHMLCPSKISPFL 351
Query: 603 -LDFSGNAL--------GHMWAEGDLYLHFFQ------------GLSGLIWLDLSQNRLH 641
LDFS N L GH+ L L Q + L LD+SQN +
Sbjct: 352 HLDFSNNLLTDTVFENCGHLTELETLILQMNQLKELSKIAEMTTQMKSLQQLDISQNSVS 411
Query: 642 TLLPQTLRNLPKSLQVLRLRDNYLAFFKWWSLHFLPKLEVLDLAGNQLKALTNGSLPAGT 701
+ + KSL L + N L + L P+++VLDL N++K++ +
Sbjct: 412 YDEKKGDCSWTKSLLSLNMSSNILTDTIFRCLP--PRIKVLDLHSNKIKSIPKQVVKL-E 468
Query: 702 RLRRLDVSCNSISFVAPGFFSKAKELRELNLSANALKTVDHSWFGPLASALQILDVSANP 761
L+ L+V+ NS++ + PG S L L + N++ +F ++ + NP
Sbjct: 469 ALQELNVAFNSLTDL-PGCGS-FSSLSVLIIDHNSVSHPSADFF-QSCQKMRSIKAGDNP 525
Query: 762 LHCACG-AAFMDFLLEVQAAV-PGLPSRVKCGSPGQLQGLSIFAQDLRLCLDEALSWDCF 819
C C F+ + +V + V G P KC P +G + +D + + + +
Sbjct: 526 FQCTCELGEFVKNIDQVSSEVLEGWPDSYKCDYPESYRGTLL--KDFHMS-ELSCNITLL 582
Query: 820 ALSLLAVALGLGVPMLHHLCGW-DL-WYCFHLCLAWLPWRGRQSG----RDEDALPYDAF 873
++++A L L V + LC + DL WY +C W R R + L + AF
Sbjct: 583 IVTIVATMLVLAVTVT-SLCSYLDLPWYLRMVC-QWTQTRRRARNIPLEELQRNLQFHAF 640
Query: 874 VVFDKTQSAVADWVYNELRGQLEECRGRWALRLCLEERDWLPGKTLFENLWASVYGSRKT 933
+ + S WV NEL LE + +++CL ER+++PGK++ EN+ + S K+
Sbjct: 641 ISYSGHDSF---WVKNELLPNLE----KEGMQICLHERNFVPGKSIVENIITCIEKSYKS 693
Query: 934 LFVLAHTDRVSGLLRASFLLAQQRLLEDRKDVVVLVILSPDGR---RSRYVRLRQRLCRQ 990
+FVL+ S A L + + ++L++L P + S Y +L+ + R+
Sbjct: 694 IFVLSPNFVQSEWCHYELYFAHHNLFHEGSNSLILILLEPIPQYSIPSSYHKLKSLMARR 753
Query: 991 SVLLWPHQPSGQRSFWAQLGMAL 1013
+ L WP + S + FWA L A+
Sbjct: 754 TYLEWPKEKSKRGLFWANLRAAI 776
Score = 38.9 bits (89), Expect = 0.025
Identities = 27/81 (33%), Positives = 43/81 (53%), Gaps = 4/81 (4%)
Query: 475 FTLDLSRNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLD 534
F +D S+N L+ V ++ + + L +S N IS+ S L L+ L++L +SHN++
Sbjct: 27 FLVDRSKNGLIHVPKDLSQKTT---ILNISQNYISELWT-SDILSLSKLRILIISHNRIQ 82
Query: 535 LYHEHSFTELPRLEALDLSYN 555
F LE LDLS+N
Sbjct: 83 YLDISVFKFNQELEYLDLSHN 103
>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
sapiens]
Length = 587
Score = 105 bits (262), Expect = 2e-22
Identities = 119/425 (28%), Positives = 180/425 (42%), Gaps = 73/425 (17%)
Query: 135 IMTVPA-LPKSLISLSLSHTNILMLDSASLAGLHALRFLFMDGNCYYKNPCRQALEVAPG 193
I+ VP LP + +SL + +T+I L+ + + AL L ++ N + + PG
Sbjct: 50 IVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRIEKN--------ELSRITPG 101
Query: 194 ALLGLGNLTHLSLKYNNLTVVPRNL---PSSLEYLLLSYNRIVKLAPEDLANLTALRVLD 250
A LG+L +LSL N L V+P L SLE LLLS N+++++ P + + L+ L
Sbjct: 102 AFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQ 161
Query: 251 VGGNCRRCDHAPNPCMECPRHFPQLHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNL 310
+ GN H + F HL L L L +SL+ ++ F+ LGNL
Sbjct: 162 LHGN----------------HLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNL 205
Query: 311 RVLDLSENFLYKCITKTKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSFGSLVALKELD 370
+VL L EN L T F GL L++L L Q ++ L + +L L +
Sbjct: 206 QVLRLYENRLTDIPMGT--FDGLVNLQELALQ---QNQIGLLSPGLFHNNHNLQRLYLSN 260
Query: 371 MHGIFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYVDLSDNRISGA 430
H + + +LP L L L N + + LGIF P LR + L DN IS
Sbjct: 261 NH------ISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSL 314
Query: 431 SELTATMGEADGGEKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLSRNNLVTVQPE 490
++ N L L LSRN + + P
Sbjct: 315 --------------------------------PDNVFSNLRQLQ-VLILSRNQISFISPG 341
Query: 491 MFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEAL 550
F L+ L+ L L N + Q ++G+ F L LQ + L +N+L + F + L A+
Sbjct: 342 AFNGLTELRELSLHTNAL-QDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAI 400
Query: 551 DLSYN 555
L N
Sbjct: 401 QLQNN 405
Score = 83.6 bits (205), Expect = 9e-16
Identities = 105/340 (30%), Positives = 153/340 (45%), Gaps = 56/340 (16%)
Query: 476 TLDLSRNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDL 535
+L + ++ + F +S L LR+ N +S+ G+ F L L+ L L++NKL +
Sbjct: 63 SLQILNTHITELNESPFLNISALIALRIEKNELSRITPGA-FRNLGSLRYLSLANNKLQV 121
Query: 536 YHEHSFTELPRLEALDLSYNS----QPFG---------MQGVGHNFSFVA-----HLRTL 577
F L LE+L LS N QP +Q G++ ++ HL L
Sbjct: 122 LPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGL 181
Query: 578 RHLSLAHNN---IHSQVSQQLCSTSLRALDFSGNALGHMWAEGDLYLHFFQGLSGLIWLD 634
L+L N+ I +V Q L +L+ L N L D+ + F GL L L
Sbjct: 182 TKLNLGKNSLTHISPRVFQHL--GNLQVLRLYENRLT------DIPMGTFDGLVNLQELA 233
Query: 635 LSQNRLHTLLPQTLRNLPKSLQVLRLRDNYLAFFKWWSLHFLPKLEVLDLAGNQLKALTN 694
L QN++ L P N +LQ L L +N+++ LP+L L L GN LK L+
Sbjct: 234 LQQNQIGLLSPGLFHN-NHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSL 292
Query: 695 G-------------------SLPAG--TRLRRLDV---SCNSISFVAPGFFSKAKELREL 730
G SLP + LR+L V S N ISF++PG F+ ELREL
Sbjct: 293 GIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELREL 352
Query: 731 NLSANALKTVDHSWFGPLASALQILDVSANPLHCACGAAF 770
+L NAL+ +D + F LA+ LQ + + N L G F
Sbjct: 353 SLHTNALQDLDGNVFRMLAN-LQNISLQNNRLRQLPGNIF 391
Score = 73.9 bits (180), Expect = 7e-13
Identities = 105/434 (24%), Positives = 167/434 (38%), Gaps = 45/434 (10%)
Query: 379 LDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYVDLSDNRIS--------GA 430
+ E P + L LR++ N +++ G FR LRY+ L++N++ G
Sbjct: 71 ITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGL 130
Query: 431 SELTATMGEADGGEKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLSRNNLVTVQPE 490
L + + + + +QP + CS L L L N+L +
Sbjct: 131 DSLESLL--LSSNQLLQIQPAHFS--------------QCSNLK-ELQLHGNHLEYIPDG 173
Query: 491 MFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEAL 550
F L L L L N ++ ++ F L LQVL L N+L +F L L+ L
Sbjct: 174 AFDHLVGLTKLNLGKNSLTH-ISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQEL 232
Query: 551 DLSYNSQPFGMQGVGHNFSFVAHLRTLRHLSLAHNNIHS---QVSQQLCSTSLRALDFSG 607
L N G+ HN L+ L L++N+I + QL L L G
Sbjct: 233 ALQQNQIGLLSPGLFHNN------HNLQRLYLSNNHISQLPPSIFMQL--PQLNRLTLFG 284
Query: 608 NALGHMWAEGDLYLHFFQGLSGLIWLDLSQNRLHTLLPQTLRNLPKSLQVLRLRDNYLAF 667
N+L +L L F + L L L N + +L NL + LQVL L N ++F
Sbjct: 285 NSLK------ELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNL-RQLQVLILSRNQISF 337
Query: 668 FKWWSLHFLPKLEVLDLAGNQLKALTNGSLPAGTRLRRLDVSCNSISFVAPGFFSKAKEL 727
+ + L +L L L N L+ L L+ + + N + + F+ L
Sbjct: 338 ISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGL 397
Query: 728 RELNLSANALKTVDHSWFGPLASALQILDVSANPLHCACGAAFMDFLLEVQAAVPGLPSR 787
+ L N L+ + F L + L + NP C + L + G +
Sbjct: 398 MAIQLQNNQLENLPLGIFDHLGKLCE-LRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTV 456
Query: 788 VKCGSPGQLQGLSI 801
C SP ++G S+
Sbjct: 457 PVCFSPANVRGQSL 470
Score = 64.7 bits (156), Expect = 4e-10
Identities = 84/343 (24%), Positives = 143/343 (41%), Gaps = 41/343 (11%)
Query: 29 LPAFLPCELQPHGLVNCNWLFLKSVPHFSMAAPRGNVTSLSLSSNRIHHLHDSDFAHLPS 88
+P LP ++N + L P +++A + +L + N + + F +L S
Sbjct: 53 VPTPLPWNAMSLQILNTHITELNESPFLNISA----LIALRIEKNELSRITPGAFRNLGS 108
Query: 89 LRHLNL---KWNCPPVGLSP---------MHFPCHMTIEPSTFLAVPTLEELNLSYNNIM 136
LR+L+L K P+GL + + I+P+ F L+EL L N++
Sbjct: 109 LRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLE 168
Query: 137 TVPALP----KSLISLSLSHTNILMLDSASLAGLHALRFLFMDGNCYYKNPCRQALEVAP 192
+P L L+L ++ + L L+ L + Y+N + ++
Sbjct: 169 YIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRL-----YEN---RLTDIPM 220
Query: 193 GALLGLGNLTHLSLKYNNLTVVPRNL---PSSLEYLLLSYNRIVKLAPEDLANLTALRVL 249
G GL NL L+L+ N + ++ L +L+ L LS N I +L P L L L
Sbjct: 221 GTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRL 280
Query: 250 DVGGNCRR----CDHAPNPCME----CPRHFPQLHPDTFSHLSRLEGLVLKDSSLSWLNA 301
+ GN + P P + H L + FS+L +L+ L+L + +S+++
Sbjct: 281 TLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISP 340
Query: 302 SWFRGLGNLRVLDLSENFLYKCITKTKAFQGLTQLRKLNLSFN 344
F GL LR L L N L F+ L L+ ++L N
Sbjct: 341 GAFNGLTELRELSLHTNALQD--LDGNVFRMLANLQNISLQNN 381
>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
sapiens]
Length = 581
Score = 105 bits (262), Expect = 2e-22
Identities = 119/425 (28%), Positives = 180/425 (42%), Gaps = 73/425 (17%)
Query: 135 IMTVPA-LPKSLISLSLSHTNILMLDSASLAGLHALRFLFMDGNCYYKNPCRQALEVAPG 193
I+ VP LP + +SL + +T+I L+ + + AL L ++ N + + PG
Sbjct: 44 IVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRIEKN--------ELSRITPG 95
Query: 194 ALLGLGNLTHLSLKYNNLTVVPRNL---PSSLEYLLLSYNRIVKLAPEDLANLTALRVLD 250
A LG+L +LSL N L V+P L SLE LLLS N+++++ P + + L+ L
Sbjct: 96 AFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQ 155
Query: 251 VGGNCRRCDHAPNPCMECPRHFPQLHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNL 310
+ GN H + F HL L L L +SL+ ++ F+ LGNL
Sbjct: 156 LHGN----------------HLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNL 199
Query: 311 RVLDLSENFLYKCITKTKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSFGSLVALKELD 370
+VL L EN L T F GL L++L L Q ++ L + +L L +
Sbjct: 200 QVLRLYENRLTDIPMGT--FDGLVNLQELALQ---QNQIGLLSPGLFHNNHNLQRLYLSN 254
Query: 371 MHGIFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYVDLSDNRISGA 430
H + + +LP L L L N + + LGIF P LR + L DN IS
Sbjct: 255 NH------ISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSL 308
Query: 431 SELTATMGEADGGEKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLSRNNLVTVQPE 490
++ N L L LSRN + + P
Sbjct: 309 --------------------------------PDNVFSNLRQLQ-VLILSRNQISFISPG 335
Query: 491 MFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEAL 550
F L+ L+ L L N + Q ++G+ F L LQ + L +N+L + F + L A+
Sbjct: 336 AFNGLTELRELSLHTNAL-QDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAI 394
Query: 551 DLSYN 555
L N
Sbjct: 395 QLQNN 399
Score = 83.6 bits (205), Expect = 9e-16
Identities = 105/340 (30%), Positives = 153/340 (45%), Gaps = 56/340 (16%)
Query: 476 TLDLSRNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDL 535
+L + ++ + F +S L LR+ N +S+ G+ F L L+ L L++NKL +
Sbjct: 57 SLQILNTHITELNESPFLNISALIALRIEKNELSRITPGA-FRNLGSLRYLSLANNKLQV 115
Query: 536 YHEHSFTELPRLEALDLSYNS----QPFG---------MQGVGHNFSFVA-----HLRTL 577
F L LE+L LS N QP +Q G++ ++ HL L
Sbjct: 116 LPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGL 175
Query: 578 RHLSLAHNN---IHSQVSQQLCSTSLRALDFSGNALGHMWAEGDLYLHFFQGLSGLIWLD 634
L+L N+ I +V Q L +L+ L N L D+ + F GL L L
Sbjct: 176 TKLNLGKNSLTHISPRVFQHL--GNLQVLRLYENRLT------DIPMGTFDGLVNLQELA 227
Query: 635 LSQNRLHTLLPQTLRNLPKSLQVLRLRDNYLAFFKWWSLHFLPKLEVLDLAGNQLKALTN 694
L QN++ L P N +LQ L L +N+++ LP+L L L GN LK L+
Sbjct: 228 LQQNQIGLLSPGLFHN-NHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSL 286
Query: 695 G-------------------SLPAG--TRLRRLDV---SCNSISFVAPGFFSKAKELREL 730
G SLP + LR+L V S N ISF++PG F+ ELREL
Sbjct: 287 GIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELREL 346
Query: 731 NLSANALKTVDHSWFGPLASALQILDVSANPLHCACGAAF 770
+L NAL+ +D + F LA+ LQ + + N L G F
Sbjct: 347 SLHTNALQDLDGNVFRMLAN-LQNISLQNNRLRQLPGNIF 385
Score = 73.9 bits (180), Expect = 7e-13
Identities = 105/434 (24%), Positives = 167/434 (38%), Gaps = 45/434 (10%)
Query: 379 LDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYVDLSDNRIS--------GA 430
+ E P + L LR++ N +++ G FR LRY+ L++N++ G
Sbjct: 65 ITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGL 124
Query: 431 SELTATMGEADGGEKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLSRNNLVTVQPE 490
L + + + + +QP + CS L L L N+L +
Sbjct: 125 DSLESLL--LSSNQLLQIQPAHFS--------------QCSNLK-ELQLHGNHLEYIPDG 167
Query: 491 MFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEAL 550
F L L L L N ++ ++ F L LQVL L N+L +F L L+ L
Sbjct: 168 AFDHLVGLTKLNLGKNSLTH-ISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQEL 226
Query: 551 DLSYNSQPFGMQGVGHNFSFVAHLRTLRHLSLAHNNIHS---QVSQQLCSTSLRALDFSG 607
L N G+ HN L+ L L++N+I + QL L L G
Sbjct: 227 ALQQNQIGLLSPGLFHNN------HNLQRLYLSNNHISQLPPSIFMQL--PQLNRLTLFG 278
Query: 608 NALGHMWAEGDLYLHFFQGLSGLIWLDLSQNRLHTLLPQTLRNLPKSLQVLRLRDNYLAF 667
N+L +L L F + L L L N + +L NL + LQVL L N ++F
Sbjct: 279 NSLK------ELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNL-RQLQVLILSRNQISF 331
Query: 668 FKWWSLHFLPKLEVLDLAGNQLKALTNGSLPAGTRLRRLDVSCNSISFVAPGFFSKAKEL 727
+ + L +L L L N L+ L L+ + + N + + F+ L
Sbjct: 332 ISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGL 391
Query: 728 RELNLSANALKTVDHSWFGPLASALQILDVSANPLHCACGAAFMDFLLEVQAAVPGLPSR 787
+ L N L+ + F L + L + NP C + L + G +
Sbjct: 392 MAIQLQNNQLENLPLGIFDHLGKLCE-LRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTV 450
Query: 788 VKCGSPGQLQGLSI 801
C SP ++G S+
Sbjct: 451 PVCFSPANVRGQSL 464
Score = 64.7 bits (156), Expect = 4e-10
Identities = 84/343 (24%), Positives = 143/343 (41%), Gaps = 41/343 (11%)
Query: 29 LPAFLPCELQPHGLVNCNWLFLKSVPHFSMAAPRGNVTSLSLSSNRIHHLHDSDFAHLPS 88
+P LP ++N + L P +++A + +L + N + + F +L S
Sbjct: 47 VPTPLPWNAMSLQILNTHITELNESPFLNISA----LIALRIEKNELSRITPGAFRNLGS 102
Query: 89 LRHLNL---KWNCPPVGLSP---------MHFPCHMTIEPSTFLAVPTLEELNLSYNNIM 136
LR+L+L K P+GL + + I+P+ F L+EL L N++
Sbjct: 103 LRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLE 162
Query: 137 TVPALP----KSLISLSLSHTNILMLDSASLAGLHALRFLFMDGNCYYKNPCRQALEVAP 192
+P L L+L ++ + L L+ L + Y+N + ++
Sbjct: 163 YIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRL-----YEN---RLTDIPM 214
Query: 193 GALLGLGNLTHLSLKYNNLTVVPRNL---PSSLEYLLLSYNRIVKLAPEDLANLTALRVL 249
G GL NL L+L+ N + ++ L +L+ L LS N I +L P L L L
Sbjct: 215 GTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRL 274
Query: 250 DVGGNCRR----CDHAPNPCME----CPRHFPQLHPDTFSHLSRLEGLVLKDSSLSWLNA 301
+ GN + P P + H L + FS+L +L+ L+L + +S+++
Sbjct: 275 TLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISP 334
Query: 302 SWFRGLGNLRVLDLSENFLYKCITKTKAFQGLTQLRKLNLSFN 344
F GL LR L L N L F+ L L+ ++L N
Sbjct: 335 GAFNGLTELRELSLHTNALQD--LDGNVFRMLANLQNISLQNN 375
>gi|62865621 toll-like receptor 10 precursor [Homo sapiens]
Length = 811
Score = 94.4 bits (233), Expect = 5e-19
Identities = 173/767 (22%), Positives = 312/767 (40%), Gaps = 80/767 (10%)
Query: 274 QLHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSENFLYKCITKTKAFQGL 333
QL F +S+L L+L + + L+ F LR LDLS N L K+ + L
Sbjct: 62 QLQSSDFHSVSKLRVLILCHNRIQQLDLKTFEFNKELRYLDLSNNRL-----KSVTWYLL 116
Query: 334 TQLRKLNLSFNYQKRVSFAHLSLAPSFGSLVALKELDMHGIFFRSLD---------ETTL 384
LR L+LSFN F + + G++ L+ L + G + D T
Sbjct: 117 AGLRYLDLSFN-----DFDTMPICEEAGNMSHLEILGLSGAKIQKSDFQKIAHLHLNTVF 171
Query: 385 RPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYVDLSDN-RISGASELTATMGEADGG 443
LP + L + +N +L I +V L D + S E+T G++
Sbjct: 172 LGFRTLPHYEEGSLPI--LNTTKLHIVLPMDTNFWVLLRDGIKTSKILEMTNIDGKSQF- 228
Query: 444 EKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLSRNNLVTV-QPEMFAQLSHLQCLR 502
++ S E+ + + LN +DL ++L + Q + H Q
Sbjct: 229 ---------VSYEMQRNLSLENAKTSVLLLN-KVDLLWDDLFLILQFVWHTSVEHFQIRN 278
Query: 503 LSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLYH---EHSFTELPRLEALDLSYNSQPF 559
++ + + S T ++ + L H +++ + + L +++ +L+ ++
Sbjct: 279 VTFGGKAYLDHNSFDYSNTVMRTIKLEHVHFRVFYIQQDKIYLLLTKMDIENLTISNAQM 338
Query: 560 GMQGVGHNFSFVAHLRTLRHLSLAHNNIHSQVSQQLCSTS-LRALDFSGNALGHMWAEGD 618
+ F + ++L+ A+N + ++ ++ L+ L +GN L E
Sbjct: 339 P------HMLFPNYPTKFQYLNFANNILTDELFKRTIQLPHLKTLILNGNKL-----ETL 387
Query: 619 LYLHFFQGLSGLIWLDLSQNRL------HTLLPQTLRNLPKSLQVLRLRDNYLAFFKWWS 672
+ F + L LDLSQN L + P+T+ N+ +L +L D+
Sbjct: 388 SLVSCFANNTPLEHLDLSQNLLQHKNDENCSWPETVVNM--NLSYNKLSDSVF------- 438
Query: 673 LHFLPK-LEVLDLAGNQLKALTNGSLPAGTRLRRLDVSCNSISFVAPGFFSKAKELRELN 731
LPK +++LDL NQ++ + ++ LR L+++ N ++ + PG S L LN
Sbjct: 439 -RCLPKSIQILDLNNNQIQTVPKETIHL-MALRELNIAFNFLTDL-PGC-SHFSRLSVLN 494
Query: 732 LSANALKTVDHSWFGPLASALQILDVSANPLHCACGAA-FMDFLLEVQAAVPGLPSRVKC 790
+ N + + F ++ L+ NP C C F+ + + G C
Sbjct: 495 IEMNFILSPSLD-FVQSCQEVKTLNAGRNPFRCTCELKNFIQLETYSEVMMVGWSDSYTC 553
Query: 791 GSPGQLQGLSIFAQDLR-LCLDEALSWDCFALSLLAVALGLGVPMLHHLCGWDLWYCFHL 849
P L+G + L L + AL + +L + L + LH W L
Sbjct: 554 EYPLNLRGTRLKDVHLHELSCNTALLIVTIVVIMLVLGLAVAFCCLHFDLPWYLRMLGQC 613
Query: 850 CLAWLPWRGRQSGRDEDALPYDAFVVFDKTQSAVADWVYNELRGQLEECRGRWALRLCLE 909
W R + + + + AF+ + + S WV NEL LE+ G ++ +CL
Sbjct: 614 TQTWHRVRKTTQEQLKRNVRFHAFISYSEHDSL---WVKNELIPNLEKEDG--SILICLY 668
Query: 910 ERDWLPGKTLFENLWASVYGSRKTLFVLAHTDRVSGLLRASFLLAQQRLLEDRKDVVVLV 969
E + PGK++ EN+ + + S K++FVL+ + F A L + D ++L+
Sbjct: 669 ESYFDPGKSISENIVSFIEKSYKSIFVLSPNFVQNEWCHYEFYFAHHNLFHENSDHIILI 728
Query: 970 ILSPDG---RRSRYVRLRQRLCRQSVLLWPHQPSGQRSFWAQLGMAL 1013
+L P +RY +L+ L +++ L WP FWA L A+
Sbjct: 729 LLEPIPFYCIPTRYHKLKALLEKKAYLEWPKDRRKCGLFWANLRAAI 775
Score = 43.9 bits (102), Expect = 8e-04
Identities = 54/199 (27%), Positives = 81/199 (40%), Gaps = 35/199 (17%)
Query: 459 DTPSSEDFRPNCSTLNF------------TLDLSRNNLVTVQPEMFAQLSHLQCLRLSHN 506
+ P + NCS ++ TLDLS N L +Q F +S L+ L L HN
Sbjct: 23 ELPEERELMTNCSNMSLRKVPADLTPATTTLDLSYNLLFQLQSSDFHSVSKLRVLILCHN 82
Query: 507 CISQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEALDLSYNSQPFGMQGVGH 566
I Q ++ F L+ LDLS+N+L ++ L L LDLS+N F +
Sbjct: 83 RIQQ-LDLKTFEFNKELRYLDLSNNRL---KSVTWYLLAGLRYLDLSFND--FDTMPICE 136
Query: 567 NFSFVAHLRTLRHLSLAHNNIHSQVSQQLCSTSLRALDFSGNALGHMWAEGDLYLHFFQG 626
++HL L L+ I Q++ L + L H + EG L +
Sbjct: 137 EAGNMSHLEI---LGLSGAKIQKSDFQKIAHLHLNTVFLGFRTLPH-YEEGSLPI----- 187
Query: 627 LSGLIWLDLSQNRLHTLLP 645
L+ +LH +LP
Sbjct: 188 --------LNTTKLHIVLP 198
Score = 38.9 bits (89), Expect = 0.025
Identities = 31/84 (36%), Positives = 45/84 (53%), Gaps = 4/84 (4%)
Query: 677 PKLEVLDLAGNQLKALTNGSLPAGTRLRRLDVSCNSISFVAPGFFSKAKELRELNLSANA 736
P LDL+ N L L + + ++LR L + N I + F KELR L+LS N
Sbjct: 48 PATTTLDLSYNLLFQLQSSDFHSVSKLRVLILCHNRIQQLDLKTFEFNKELRYLDLSNNR 107
Query: 737 LKTVDHSWFGPLASALQILDVSAN 760
LK+V +W+ L + L+ LD+S N
Sbjct: 108 LKSV--TWY--LLAGLRYLDLSFN 127
Score = 35.0 bits (79), Expect = 0.37
Identities = 33/109 (30%), Positives = 47/109 (43%), Gaps = 19/109 (17%)
Query: 210 NLTVVPRNLPSSLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGNCRRCDHAPNPCMECP 269
+L VP +L + L LSYN + +L D +++ LRVL + C
Sbjct: 38 SLRKVPADLTPATTTLDLSYNLLFQLQSSDFHSVSKLRVL----------------ILCH 81
Query: 270 RHFPQLHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSEN 318
QL TF L L L ++ L + +W+ L LR LDLS N
Sbjct: 82 NRIQQLDLKTFEFNKELRYLDLSNNRLK--SVTWYL-LAGLRYLDLSFN 127
Score = 33.9 bits (76), Expect = 0.81
Identities = 31/79 (39%), Positives = 42/79 (53%), Gaps = 4/79 (5%)
Query: 633 LDLSQNRLHTLLPQTLRNLPKSLQVLRLRDNYLAFFKWWSLHFLPKLEVLDLAGNQLKAL 692
LDLS N L L ++ K L+VL L N + + F +L LDL+ N+LK++
Sbjct: 53 LDLSYNLLFQLQSSDFHSVSK-LRVLILCHNRIQQLDLKTFEFNKELRYLDLSNNRLKSV 111
Query: 693 TNGSLPAGTRLRRLDVSCN 711
T L AG LR LD+S N
Sbjct: 112 T-WYLLAG--LRYLDLSFN 127
Score = 30.8 bits (68), Expect = 6.9
Identities = 33/128 (25%), Positives = 53/128 (41%), Gaps = 12/128 (9%)
Query: 129 NLSYNNIMTVPA-LPKSLISLSLSHTNILMLDSASLAGLHALRFLFMDGNCYYKNPCRQA 187
N S ++ VPA L + +L LS+ + L S+ + LR L + C
Sbjct: 33 NCSNMSLRKVPADLTPATTTLDLSYNLLFQLQSSDFHSVSKLRVLIL---------CHNR 83
Query: 188 LEVAPGALLGLGN-LTHLSLKYNNLTVVPRNLPSSLEYLLLSYNRIVKL-APEDLANLTA 245
++ L +L L N L V L + L YL LS+N + E+ N++
Sbjct: 84 IQQLDLKTFEFNKELRYLDLSNNRLKSVTWYLLAGLRYLDLSFNDFDTMPICEEAGNMSH 143
Query: 246 LRVLDVGG 253
L +L + G
Sbjct: 144 LEILGLSG 151
>gi|62865618 toll-like receptor 10 precursor [Homo sapiens]
Length = 811
Score = 94.4 bits (233), Expect = 5e-19
Identities = 173/767 (22%), Positives = 312/767 (40%), Gaps = 80/767 (10%)
Query: 274 QLHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSENFLYKCITKTKAFQGL 333
QL F +S+L L+L + + L+ F LR LDLS N L K+ + L
Sbjct: 62 QLQSSDFHSVSKLRVLILCHNRIQQLDLKTFEFNKELRYLDLSNNRL-----KSVTWYLL 116
Query: 334 TQLRKLNLSFNYQKRVSFAHLSLAPSFGSLVALKELDMHGIFFRSLD---------ETTL 384
LR L+LSFN F + + G++ L+ L + G + D T
Sbjct: 117 AGLRYLDLSFN-----DFDTMPICEEAGNMSHLEILGLSGAKIQKSDFQKIAHLHLNTVF 171
Query: 385 RPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYVDLSDN-RISGASELTATMGEADGG 443
LP + L + +N +L I +V L D + S E+T G++
Sbjct: 172 LGFRTLPHYEEGSLPI--LNTTKLHIVLPMDTNFWVLLRDGIKTSKILEMTNIDGKSQF- 228
Query: 444 EKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLSRNNLVTV-QPEMFAQLSHLQCLR 502
++ S E+ + + LN +DL ++L + Q + H Q
Sbjct: 229 ---------VSYEMQRNLSLENAKTSVLLLN-KVDLLWDDLFLILQFVWHTSVEHFQIRN 278
Query: 503 LSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLYH---EHSFTELPRLEALDLSYNSQPF 559
++ + + S T ++ + L H +++ + + L +++ +L+ ++
Sbjct: 279 VTFGGKAYLDHNSFDYSNTVMRTIKLEHVHFRVFYIQQDKIYLLLTKMDIENLTISNAQM 338
Query: 560 GMQGVGHNFSFVAHLRTLRHLSLAHNNIHSQVSQQLCSTS-LRALDFSGNALGHMWAEGD 618
+ F + ++L+ A+N + ++ ++ L+ L +GN L E
Sbjct: 339 P------HMLFPNYPTKFQYLNFANNILTDELFKRTIQLPHLKTLILNGNKL-----ETL 387
Query: 619 LYLHFFQGLSGLIWLDLSQNRL------HTLLPQTLRNLPKSLQVLRLRDNYLAFFKWWS 672
+ F + L LDLSQN L + P+T+ N+ +L +L D+
Sbjct: 388 SLVSCFANNTPLEHLDLSQNLLQHKNDENCSWPETVVNM--NLSYNKLSDSVF------- 438
Query: 673 LHFLPK-LEVLDLAGNQLKALTNGSLPAGTRLRRLDVSCNSISFVAPGFFSKAKELRELN 731
LPK +++LDL NQ++ + ++ LR L+++ N ++ + PG S L LN
Sbjct: 439 -RCLPKSIQILDLNNNQIQTVPKETIHL-MALRELNIAFNFLTDL-PGC-SHFSRLSVLN 494
Query: 732 LSANALKTVDHSWFGPLASALQILDVSANPLHCACGAA-FMDFLLEVQAAVPGLPSRVKC 790
+ N + + F ++ L+ NP C C F+ + + G C
Sbjct: 495 IEMNFILSPSLD-FVQSCQEVKTLNAGRNPFRCTCELKNFIQLETYSEVMMVGWSDSYTC 553
Query: 791 GSPGQLQGLSIFAQDLR-LCLDEALSWDCFALSLLAVALGLGVPMLHHLCGWDLWYCFHL 849
P L+G + L L + AL + +L + L + LH W L
Sbjct: 554 EYPLNLRGTRLKDVHLHELSCNTALLIVTIVVIMLVLGLAVAFCCLHFDLPWYLRMLGQC 613
Query: 850 CLAWLPWRGRQSGRDEDALPYDAFVVFDKTQSAVADWVYNELRGQLEECRGRWALRLCLE 909
W R + + + + AF+ + + S WV NEL LE+ G ++ +CL
Sbjct: 614 TQTWHRVRKTTQEQLKRNVRFHAFISYSEHDSL---WVKNELIPNLEKEDG--SILICLY 668
Query: 910 ERDWLPGKTLFENLWASVYGSRKTLFVLAHTDRVSGLLRASFLLAQQRLLEDRKDVVVLV 969
E + PGK++ EN+ + + S K++FVL+ + F A L + D ++L+
Sbjct: 669 ESYFDPGKSISENIVSFIEKSYKSIFVLSPNFVQNEWCHYEFYFAHHNLFHENSDHIILI 728
Query: 970 ILSPDG---RRSRYVRLRQRLCRQSVLLWPHQPSGQRSFWAQLGMAL 1013
+L P +RY +L+ L +++ L WP FWA L A+
Sbjct: 729 LLEPIPFYCIPTRYHKLKALLEKKAYLEWPKDRRKCGLFWANLRAAI 775
Score = 43.9 bits (102), Expect = 8e-04
Identities = 54/199 (27%), Positives = 81/199 (40%), Gaps = 35/199 (17%)
Query: 459 DTPSSEDFRPNCSTLNF------------TLDLSRNNLVTVQPEMFAQLSHLQCLRLSHN 506
+ P + NCS ++ TLDLS N L +Q F +S L+ L L HN
Sbjct: 23 ELPEERELMTNCSNMSLRKVPADLTPATTTLDLSYNLLFQLQSSDFHSVSKLRVLILCHN 82
Query: 507 CISQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEALDLSYNSQPFGMQGVGH 566
I Q ++ F L+ LDLS+N+L ++ L L LDLS+N F +
Sbjct: 83 RIQQ-LDLKTFEFNKELRYLDLSNNRL---KSVTWYLLAGLRYLDLSFND--FDTMPICE 136
Query: 567 NFSFVAHLRTLRHLSLAHNNIHSQVSQQLCSTSLRALDFSGNALGHMWAEGDLYLHFFQG 626
++HL L L+ I Q++ L + L H + EG L +
Sbjct: 137 EAGNMSHLEI---LGLSGAKIQKSDFQKIAHLHLNTVFLGFRTLPH-YEEGSLPI----- 187
Query: 627 LSGLIWLDLSQNRLHTLLP 645
L+ +LH +LP
Sbjct: 188 --------LNTTKLHIVLP 198
Score = 38.9 bits (89), Expect = 0.025
Identities = 31/84 (36%), Positives = 45/84 (53%), Gaps = 4/84 (4%)
Query: 677 PKLEVLDLAGNQLKALTNGSLPAGTRLRRLDVSCNSISFVAPGFFSKAKELRELNLSANA 736
P LDL+ N L L + + ++LR L + N I + F KELR L+LS N
Sbjct: 48 PATTTLDLSYNLLFQLQSSDFHSVSKLRVLILCHNRIQQLDLKTFEFNKELRYLDLSNNR 107
Query: 737 LKTVDHSWFGPLASALQILDVSAN 760
LK+V +W+ L + L+ LD+S N
Sbjct: 108 LKSV--TWY--LLAGLRYLDLSFN 127
Score = 35.0 bits (79), Expect = 0.37
Identities = 33/109 (30%), Positives = 47/109 (43%), Gaps = 19/109 (17%)
Query: 210 NLTVVPRNLPSSLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGNCRRCDHAPNPCMECP 269
+L VP +L + L LSYN + +L D +++ LRVL + C
Sbjct: 38 SLRKVPADLTPATTTLDLSYNLLFQLQSSDFHSVSKLRVL----------------ILCH 81
Query: 270 RHFPQLHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSEN 318
QL TF L L L ++ L + +W+ L LR LDLS N
Sbjct: 82 NRIQQLDLKTFEFNKELRYLDLSNNRLK--SVTWYL-LAGLRYLDLSFN 127
Score = 33.9 bits (76), Expect = 0.81
Identities = 31/79 (39%), Positives = 42/79 (53%), Gaps = 4/79 (5%)
Query: 633 LDLSQNRLHTLLPQTLRNLPKSLQVLRLRDNYLAFFKWWSLHFLPKLEVLDLAGNQLKAL 692
LDLS N L L ++ K L+VL L N + + F +L LDL+ N+LK++
Sbjct: 53 LDLSYNLLFQLQSSDFHSVSK-LRVLILCHNRIQQLDLKTFEFNKELRYLDLSNNRLKSV 111
Query: 693 TNGSLPAGTRLRRLDVSCN 711
T L AG LR LD+S N
Sbjct: 112 T-WYLLAG--LRYLDLSFN 127
Score = 30.8 bits (68), Expect = 6.9
Identities = 33/128 (25%), Positives = 53/128 (41%), Gaps = 12/128 (9%)
Query: 129 NLSYNNIMTVPA-LPKSLISLSLSHTNILMLDSASLAGLHALRFLFMDGNCYYKNPCRQA 187
N S ++ VPA L + +L LS+ + L S+ + LR L + C
Sbjct: 33 NCSNMSLRKVPADLTPATTTLDLSYNLLFQLQSSDFHSVSKLRVLIL---------CHNR 83
Query: 188 LEVAPGALLGLGN-LTHLSLKYNNLTVVPRNLPSSLEYLLLSYNRIVKL-APEDLANLTA 245
++ L +L L N L V L + L YL LS+N + E+ N++
Sbjct: 84 IQQLDLKTFEFNKELRYLDLSNNRLKSVTWYLLAGLRYLDLSFNDFDTMPICEEAGNMSH 143
Query: 246 LRVLDVGG 253
L +L + G
Sbjct: 144 LEILGLSG 151
>gi|193083139 leucine rich repeat containing 32 precursor [Homo
sapiens]
Length = 662
Score = 93.2 bits (230), Expect = 1e-18
Identities = 159/612 (25%), Positives = 235/612 (38%), Gaps = 107/612 (17%)
Query: 204 LSLKYNNLTVVPRNLPSSLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGNCRRCDHAPN 263
+S + L VP LP E L LS N++ + L TALR LD+ N
Sbjct: 33 VSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTN--------- 83
Query: 264 PCMECPRHFPQLHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNL-RV--LDLSENFL 320
L P F L+ LE L L + L+ A GLG L RV LDLS N L
Sbjct: 84 -------EISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSL 136
Query: 321 YKCITKTKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSFGSLVALKELDMHGIFFRSLD 380
Y + + + L L+L+ N R++ +F + AL++LD+H ++
Sbjct: 137 YSGLLE-RLLGEAPSLHTLSLAENSLTRLT------RHTFRDMPALEQLDLHSNVLMDIE 189
Query: 381 ETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFP-------------------GLRYVD 421
+ L RL L R + I+ L R L ++D
Sbjct: 190 DGAFEGLPRLTHLNLSRNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLD 249
Query: 422 LSDNRISGASELTA----------------TMGEADGGEKVWLQPGDLAPAPVDTPS-SE 464
L +N++ +L A G + + + P+ PS +
Sbjct: 250 LRENKLLHFPDLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNA 309
Query: 465 DFRPNCSTLNFTLDLSRNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQ 524
RP LN LDLS N + + L+ L L LS NC+ + + L L
Sbjct: 310 SGRPLSQLLN--LDLSYNEIELIPDSFLEHLTSLCFLNLSRNCL-RTFEARRLGSLPCLM 366
Query: 525 VLDLSHNKLDLYHEHSFTELPRLEALDLSYNSQPFGMQGVGHNFSFVAHLRTLRHLSLAH 584
+LDLSHN LE L+L G + +G +LR L L
Sbjct: 367 LLDLSHN--------------ALETLEL-------GARALG----------SLRTLLLQG 395
Query: 585 NNIHSQVSQQLCS-TSLRALDFSGNAL---GHMWAEGDLYLHFFQGLSGLIWLDLSQNRL 640
N + + SL+ L+ GN + G G F G++ L L L N +
Sbjct: 396 NALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEI 455
Query: 641 HTLLPQTLRNLPKSLQVLRLRDNYLAFFKWWSLHFL-PKLEVLDLAGNQLKALTNGSLPA 699
L + P L L L N +L L LEVL L GN L L LP
Sbjct: 456 ELLRAGAFLHTP--LTELDLSSNPGLEVATGALGGLEASLEVLALQGNGLMVL-QVDLPC 512
Query: 700 GTRLRRLDVSCNSISFVAPGFFSKAKELRELNLSANALKTVDHSWFGPLASALQILDVSA 759
L+RL+++ N +S + +++A L L+L N+ + S G L ++L+ L +
Sbjct: 513 FICLKRLNLAENRLSHLPA--WTQAVSLEVLDLRNNSFSLLPGSAMGGLETSLRRLYLQG 570
Query: 760 NPLHCACGAAFM 771
NPL C CG ++
Sbjct: 571 NPLSC-CGNGWL 581
Score = 88.2 bits (217), Expect = 4e-17
Identities = 170/618 (27%), Positives = 239/618 (38%), Gaps = 109/618 (17%)
Query: 135 IMTVPA-LPKSLISLSLSHTNILMLDSASLAGLHALRFLFMDGNCYYKNPCRQALEVAPG 193
++ VP+ LP +L LS + + ++ L ALR L + N + + PG
Sbjct: 40 LLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTN--------EISFLQPG 91
Query: 194 ALLGLGNLTHLSLKYNNLTVVPRNLPSSLEYLLLSYNRIVKLAPEDLANLTALRVLDVGG 253
A L +L HLSL +N L + L+ L L + LD+ G
Sbjct: 92 AFQALTHLEHLSLAHNRLAMA------------------TALSAGGLGPLPRVTSLDLSG 133
Query: 254 NCRRCDHAPNPCMECPRHFPQLHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNLRVL 313
N E P L L L ++SL+ L FR + L L
Sbjct: 134 NSLYSGLLERLLGEAPS---------------LHTLSLAENSLTRLTRHTFRDMPALEQL 178
Query: 314 DLSENFLYKCITKTKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSFGSLVALKELDMHG 373
DL N L + AF+GL +L LNLS N L+ F SL L+ LD+
Sbjct: 179 DLHSNVLMDI--EDGAFEGLPRLTHLNLSRN--------SLTCISDF-SLQQLRVLDLSC 227
Query: 374 IFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYVDLSDNRIS----- 428
+ +T +P A L L L+ N + A P L Y++LS+N I
Sbjct: 228 NSIEAF-QTASQPQAEF-QLTWLDLRENKL--LHFPDLAALPRLIYLNLSNNLIRLPTGP 283
Query: 429 --------------GASELTATMGEADGGEKVWLQPGDLAPAPVDTPSSEDFRPNCSTLN 474
A L+A G A G L DL+ ++ + F + ++L
Sbjct: 284 PQDSKGIHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSYNEIEL-IPDSFLEHLTSLC 342
Query: 475 FTLDLSRNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLD 534
F L+LSRN L T + L L L LSHN + G++ L L+ L L N L
Sbjct: 343 F-LNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLELGAR--ALGSLRTLLLQGNALR 399
Query: 535 LYHEHSFTELPRLEALDLSYNS-QPFGMQGVGHNFSFVAH--LRTLRHLSLAHNNIHSQV 591
++F L L+ L+L N P G VA + +LR LSL N I
Sbjct: 400 DLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEIELLR 459
Query: 592 SQQLCSTSLRALDFSGN--------ALGHMWAEGDLYLHFFQGLSGLIW----------- 632
+ T L LD S N ALG + E L + QG ++
Sbjct: 460 AGAFLHTPLTELDLSSNPGLEVATGALGGL--EASLEVLALQGNGLMVLQVDLPCFICLK 517
Query: 633 -LDLSQNRLHTLLPQTLRNLPKSLQVLRLRDNYLAFFKWWSLHFLP-KLEVLDLAGNQLK 690
L+L++NRL L T SL+VL LR+N + ++ L L L L GN L
Sbjct: 518 RLNLAENRLSHLPAWTQA---VSLEVLDLRNNSFSLLPGSAMGGLETSLRRLYLQGNPLS 574
Query: 691 ALTNGSLPAGTRLRRLDV 708
NG L A R+DV
Sbjct: 575 CCGNGWLAAQLHQGRVDV 592
Score = 64.3 bits (155), Expect = 6e-10
Identities = 153/606 (25%), Positives = 221/606 (36%), Gaps = 127/606 (20%)
Query: 16 QAIMLAMTLALGTLPAF---LPCELQPHGLVNCNWLFLKSVPHFSMAAPRGNVTSLSLSS 72
Q ++L L LG +PC++ V+C L L VP S+ P + +L LS
Sbjct: 4 QILLLLALLTLGLAAQHQDKVPCKMVDKK-VSCQVLGLLQVP--SVLPP--DTETLDLSG 58
Query: 73 NRIHHLHDSDFAHLPSLRHLNLKWNCPPVGLSPMHFPCHMTIEPSTFLAVPTLEELNLSY 132
N++ + S +LRHL+L N + F ++P F A+ LE L+L++
Sbjct: 59 NQLRSILASPLGFYTALRHLDLSTN-------EISF-----LQPGAFQALTHLEHLSLAH 106
Query: 133 NNIMTVPALPK--------------------------------SLISLSLSHTNILMLDS 160
N + AL SL +LSL+ ++ L
Sbjct: 107 NRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTR 166
Query: 161 ASLAGLHALRFLFMDGNCYYKNPCRQALEVAPGALLGLGNLTHLSLKYNNLTVVPRNLPS 220
+ + AL L + N +++ GA GL LTHL+L N+LT +
Sbjct: 167 HTFRDMPALEQLDLHSNVL--------MDIEDGAFEGLPRLTHLNLSRNSLTCISDFSLQ 218
Query: 221 SLEYLLLSYNRIVK-----------------------LAPEDLANLTALRVLDVGGNCRR 257
L L LS N I L DLA L L L++ N R
Sbjct: 219 QLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHFPDLAALPRLIYLNLSNNLIR 278
Query: 258 CDHAPNPCMECPRHFPQLHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSE 317
P P+ +H + EG S NAS R L L LDLS
Sbjct: 279 LPTGP------PQDSKGIHAPS-------EGWSALPLSAPSGNASG-RPLSQLLNLDLSY 324
Query: 318 NFLYKCITKTKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSFGSLVALKELDMHGIFFR 377
N + + + LT L LNLS N + A GSL L LD+
Sbjct: 325 NEIE--LIPDSFLEHLTSLCFLNLSRNCLRTFE------ARRLGSLPCLMLLDLS----H 372
Query: 378 SLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYVDLSDNRIS--GASELTA 435
+ ET L L+TL LQ N + F L+ ++L NR+S G +
Sbjct: 373 NALETLELGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPG 432
Query: 436 TMGEADGGEKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLSRNNLVTVQPEMFAQL 495
G L+ L ++ + F T LDLS N P +
Sbjct: 433 PSGCVAFSGITSLRSLSLVDNEIELLRAGAFLHTPLT---ELDLSSN------PGLEVAT 483
Query: 496 SHLQCLRLSHNCISQAVNGSQFLPL-----TGLQVLDLSHNKLDLYHEHSFTELPRLEAL 550
L L S ++ NG L + L+ L+L+ N+L H ++T+ LE L
Sbjct: 484 GALGGLEASLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRLS--HLPAWTQAVSLEVL 541
Query: 551 DLSYNS 556
DL NS
Sbjct: 542 DLRNNS 547
Score = 64.3 bits (155), Expect = 6e-10
Identities = 98/327 (29%), Positives = 139/327 (42%), Gaps = 45/327 (13%)
Query: 58 MAAPRGNVT--------SLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCPPVGLSPMHFP 109
++AP GN + +L LS N I + DS HL SL LNL N
Sbjct: 302 LSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRN------------ 349
Query: 110 CHMTIEPSTFLAVPTLEELNLSYNNIMTVPALPK---SLISLSLSHTNILMLDSASLAGL 166
C T E ++P L L+LS+N + T+ + SL +L L + L + A L
Sbjct: 350 CLRTFEARRLGSLPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPPYTFANL 409
Query: 167 HALRFLFMDGNCYYKNPCRQALEVAPG---ALLGLGNLTHLSLKYNNLTVVPRN--LPSS 221
+L+ L + GN +PC E P A G+ +L LSL N + ++ L +
Sbjct: 410 ASLQRLNLQGN--RVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAFLHTP 467
Query: 222 LEYLLLSYNRIVKLAPEDLANLTA-LRVLDVGGNCRRCDHAPNPCMECPRHFPQLHPDTF 280
L L LS N +++A L L A L VL + GN PC C + L +
Sbjct: 468 LTELDLSSNPGLEVATGALGGLEASLEVLALQGNGLMVLQVDLPCFICLKRL-NLAENRL 526
Query: 281 SHLS------RLEGLVLKDSSLSWLNASWFRGL-GNLRVLDLSENFLYKCITKTKAFQ-- 331
SHL LE L L+++S S L S GL +LR L L N L C A Q
Sbjct: 527 SHLPAWTQAVSLEVLDLRNNSFSLLPGSAMGGLETSLRRLYLQGNPLSCCGNGWLAAQLH 586
Query: 332 ----GLTQLRKLNLSFNYQKRVSFAHL 354
+ + L F+ Q+ VS +H+
Sbjct: 587 QGRVDVDATQDLICRFSSQEEVSLSHV 613
>gi|5031707 leucine rich repeat containing 32 precursor [Homo
sapiens]
Length = 662
Score = 93.2 bits (230), Expect = 1e-18
Identities = 159/612 (25%), Positives = 235/612 (38%), Gaps = 107/612 (17%)
Query: 204 LSLKYNNLTVVPRNLPSSLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGNCRRCDHAPN 263
+S + L VP LP E L LS N++ + L TALR LD+ N
Sbjct: 33 VSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTN--------- 83
Query: 264 PCMECPRHFPQLHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNL-RV--LDLSENFL 320
L P F L+ LE L L + L+ A GLG L RV LDLS N L
Sbjct: 84 -------EISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSL 136
Query: 321 YKCITKTKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSFGSLVALKELDMHGIFFRSLD 380
Y + + + L L+L+ N R++ +F + AL++LD+H ++
Sbjct: 137 YSGLLE-RLLGEAPSLHTLSLAENSLTRLT------RHTFRDMPALEQLDLHSNVLMDIE 189
Query: 381 ETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFP-------------------GLRYVD 421
+ L RL L R + I+ L R L ++D
Sbjct: 190 DGAFEGLPRLTHLNLSRNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLD 249
Query: 422 LSDNRISGASELTA----------------TMGEADGGEKVWLQPGDLAPAPVDTPS-SE 464
L +N++ +L A G + + + P+ PS +
Sbjct: 250 LRENKLLHFPDLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNA 309
Query: 465 DFRPNCSTLNFTLDLSRNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQ 524
RP LN LDLS N + + L+ L L LS NC+ + + L L
Sbjct: 310 SGRPLSQLLN--LDLSYNEIELIPDSFLEHLTSLCFLNLSRNCL-RTFEARRLGSLPCLM 366
Query: 525 VLDLSHNKLDLYHEHSFTELPRLEALDLSYNSQPFGMQGVGHNFSFVAHLRTLRHLSLAH 584
+LDLSHN LE L+L G + +G +LR L L
Sbjct: 367 LLDLSHN--------------ALETLEL-------GARALG----------SLRTLLLQG 395
Query: 585 NNIHSQVSQQLCS-TSLRALDFSGNAL---GHMWAEGDLYLHFFQGLSGLIWLDLSQNRL 640
N + + SL+ L+ GN + G G F G++ L L L N +
Sbjct: 396 NALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEI 455
Query: 641 HTLLPQTLRNLPKSLQVLRLRDNYLAFFKWWSLHFL-PKLEVLDLAGNQLKALTNGSLPA 699
L + P L L L N +L L LEVL L GN L L LP
Sbjct: 456 ELLRAGAFLHTP--LTELDLSSNPGLEVATGALGGLEASLEVLALQGNGLMVL-QVDLPC 512
Query: 700 GTRLRRLDVSCNSISFVAPGFFSKAKELRELNLSANALKTVDHSWFGPLASALQILDVSA 759
L+RL+++ N +S + +++A L L+L N+ + S G L ++L+ L +
Sbjct: 513 FICLKRLNLAENRLSHLPA--WTQAVSLEVLDLRNNSFSLLPGSAMGGLETSLRRLYLQG 570
Query: 760 NPLHCACGAAFM 771
NPL C CG ++
Sbjct: 571 NPLSC-CGNGWL 581
Score = 88.2 bits (217), Expect = 4e-17
Identities = 170/618 (27%), Positives = 239/618 (38%), Gaps = 109/618 (17%)
Query: 135 IMTVPA-LPKSLISLSLSHTNILMLDSASLAGLHALRFLFMDGNCYYKNPCRQALEVAPG 193
++ VP+ LP +L LS + + ++ L ALR L + N + + PG
Sbjct: 40 LLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTN--------EISFLQPG 91
Query: 194 ALLGLGNLTHLSLKYNNLTVVPRNLPSSLEYLLLSYNRIVKLAPEDLANLTALRVLDVGG 253
A L +L HLSL +N L + L+ L L + LD+ G
Sbjct: 92 AFQALTHLEHLSLAHNRLAMA------------------TALSAGGLGPLPRVTSLDLSG 133
Query: 254 NCRRCDHAPNPCMECPRHFPQLHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNLRVL 313
N E P L L L ++SL+ L FR + L L
Sbjct: 134 NSLYSGLLERLLGEAPS---------------LHTLSLAENSLTRLTRHTFRDMPALEQL 178
Query: 314 DLSENFLYKCITKTKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSFGSLVALKELDMHG 373
DL N L + AF+GL +L LNLS N L+ F SL L+ LD+
Sbjct: 179 DLHSNVLMDI--EDGAFEGLPRLTHLNLSRN--------SLTCISDF-SLQQLRVLDLSC 227
Query: 374 IFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYVDLSDNRIS----- 428
+ +T +P A L L L+ N + A P L Y++LS+N I
Sbjct: 228 NSIEAF-QTASQPQAEF-QLTWLDLRENKL--LHFPDLAALPRLIYLNLSNNLIRLPTGP 283
Query: 429 --------------GASELTATMGEADGGEKVWLQPGDLAPAPVDTPSSEDFRPNCSTLN 474
A L+A G A G L DL+ ++ + F + ++L
Sbjct: 284 PQDSKGIHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSYNEIEL-IPDSFLEHLTSLC 342
Query: 475 FTLDLSRNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLD 534
F L+LSRN L T + L L L LSHN + G++ L L+ L L N L
Sbjct: 343 F-LNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLELGAR--ALGSLRTLLLQGNALR 399
Query: 535 LYHEHSFTELPRLEALDLSYNS-QPFGMQGVGHNFSFVAH--LRTLRHLSLAHNNIHSQV 591
++F L L+ L+L N P G VA + +LR LSL N I
Sbjct: 400 DLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEIELLR 459
Query: 592 SQQLCSTSLRALDFSGN--------ALGHMWAEGDLYLHFFQGLSGLIW----------- 632
+ T L LD S N ALG + E L + QG ++
Sbjct: 460 AGAFLHTPLTELDLSSNPGLEVATGALGGL--EASLEVLALQGNGLMVLQVDLPCFICLK 517
Query: 633 -LDLSQNRLHTLLPQTLRNLPKSLQVLRLRDNYLAFFKWWSLHFLP-KLEVLDLAGNQLK 690
L+L++NRL L T SL+VL LR+N + ++ L L L L GN L
Sbjct: 518 RLNLAENRLSHLPAWTQA---VSLEVLDLRNNSFSLLPGSAMGGLETSLRRLYLQGNPLS 574
Query: 691 ALTNGSLPAGTRLRRLDV 708
NG L A R+DV
Sbjct: 575 CCGNGWLAAQLHQGRVDV 592
Score = 64.3 bits (155), Expect = 6e-10
Identities = 153/606 (25%), Positives = 221/606 (36%), Gaps = 127/606 (20%)
Query: 16 QAIMLAMTLALGTLPAF---LPCELQPHGLVNCNWLFLKSVPHFSMAAPRGNVTSLSLSS 72
Q ++L L LG +PC++ V+C L L VP S+ P + +L LS
Sbjct: 4 QILLLLALLTLGLAAQHQDKVPCKMVDKK-VSCQVLGLLQVP--SVLPP--DTETLDLSG 58
Query: 73 NRIHHLHDSDFAHLPSLRHLNLKWNCPPVGLSPMHFPCHMTIEPSTFLAVPTLEELNLSY 132
N++ + S +LRHL+L N + F ++P F A+ LE L+L++
Sbjct: 59 NQLRSILASPLGFYTALRHLDLSTN-------EISF-----LQPGAFQALTHLEHLSLAH 106
Query: 133 NNIMTVPALPK--------------------------------SLISLSLSHTNILMLDS 160
N + AL SL +LSL+ ++ L
Sbjct: 107 NRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTR 166
Query: 161 ASLAGLHALRFLFMDGNCYYKNPCRQALEVAPGALLGLGNLTHLSLKYNNLTVVPRNLPS 220
+ + AL L + N +++ GA GL LTHL+L N+LT +
Sbjct: 167 HTFRDMPALEQLDLHSNVL--------MDIEDGAFEGLPRLTHLNLSRNSLTCISDFSLQ 218
Query: 221 SLEYLLLSYNRIVK-----------------------LAPEDLANLTALRVLDVGGNCRR 257
L L LS N I L DLA L L L++ N R
Sbjct: 219 QLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHFPDLAALPRLIYLNLSNNLIR 278
Query: 258 CDHAPNPCMECPRHFPQLHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSE 317
P P+ +H + EG S NAS R L L LDLS
Sbjct: 279 LPTGP------PQDSKGIHAPS-------EGWSALPLSAPSGNASG-RPLSQLLNLDLSY 324
Query: 318 NFLYKCITKTKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSFGSLVALKELDMHGIFFR 377
N + + + LT L LNLS N + A GSL L LD+
Sbjct: 325 NEIE--LIPDSFLEHLTSLCFLNLSRNCLRTFE------ARRLGSLPCLMLLDLS----H 372
Query: 378 SLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYVDLSDNRIS--GASELTA 435
+ ET L L+TL LQ N + F L+ ++L NR+S G +
Sbjct: 373 NALETLELGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPG 432
Query: 436 TMGEADGGEKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLSRNNLVTVQPEMFAQL 495
G L+ L ++ + F T LDLS N P +
Sbjct: 433 PSGCVAFSGITSLRSLSLVDNEIELLRAGAFLHTPLT---ELDLSSN------PGLEVAT 483
Query: 496 SHLQCLRLSHNCISQAVNGSQFLPL-----TGLQVLDLSHNKLDLYHEHSFTELPRLEAL 550
L L S ++ NG L + L+ L+L+ N+L H ++T+ LE L
Sbjct: 484 GALGGLEASLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRLS--HLPAWTQAVSLEVL 541
Query: 551 DLSYNS 556
DL NS
Sbjct: 542 DLRNNS 547
Score = 64.3 bits (155), Expect = 6e-10
Identities = 98/327 (29%), Positives = 139/327 (42%), Gaps = 45/327 (13%)
Query: 58 MAAPRGNVT--------SLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCPPVGLSPMHFP 109
++AP GN + +L LS N I + DS HL SL LNL N
Sbjct: 302 LSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRN------------ 349
Query: 110 CHMTIEPSTFLAVPTLEELNLSYNNIMTVPALPK---SLISLSLSHTNILMLDSASLAGL 166
C T E ++P L L+LS+N + T+ + SL +L L + L + A L
Sbjct: 350 CLRTFEARRLGSLPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPPYTFANL 409
Query: 167 HALRFLFMDGNCYYKNPCRQALEVAPG---ALLGLGNLTHLSLKYNNLTVVPRN--LPSS 221
+L+ L + GN +PC E P A G+ +L LSL N + ++ L +
Sbjct: 410 ASLQRLNLQGN--RVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAFLHTP 467
Query: 222 LEYLLLSYNRIVKLAPEDLANLTA-LRVLDVGGNCRRCDHAPNPCMECPRHFPQLHPDTF 280
L L LS N +++A L L A L VL + GN PC C + L +
Sbjct: 468 LTELDLSSNPGLEVATGALGGLEASLEVLALQGNGLMVLQVDLPCFICLKRL-NLAENRL 526
Query: 281 SHLS------RLEGLVLKDSSLSWLNASWFRGL-GNLRVLDLSENFLYKCITKTKAFQ-- 331
SHL LE L L+++S S L S GL +LR L L N L C A Q
Sbjct: 527 SHLPAWTQAVSLEVLDLRNNSFSLLPGSAMGGLETSLRRLYLQGNPLSCCGNGWLAAQLH 586
Query: 332 ----GLTQLRKLNLSFNYQKRVSFAHL 354
+ + L F+ Q+ VS +H+
Sbjct: 587 QGRVDVDATQDLICRFSSQEEVSLSHV 613
>gi|194440719 chondroadherin-like [Homo sapiens]
Length = 762
Score = 92.8 bits (229), Expect = 1e-18
Identities = 201/748 (26%), Positives = 281/748 (37%), Gaps = 159/748 (21%)
Query: 132 YNNIMTVP-ALPKSLISLSLSHTNILMLDSASLAGLHALRFLFMDGNCYYKNPCRQALEV 190
Y N+ VP A+P+ L L + ++ +A+ G+ L L + C L V
Sbjct: 50 YQNLTEVPDAIPELTQRLDLQGNLLKVIPAAAFQGVPHLTHLDL-------RHCEVEL-V 101
Query: 191 APGALLGLGNLTHLSLKYNNLTVVPRNLPS---SLEYLLLSYNRIVKLAPEDLANLTALR 247
A GA GLG L L+L N+L +P+ SL L L N + +L P L AL
Sbjct: 102 AEGAFRGLGRLLLLNLASNHLRELPQEALDGLGSLRRLELEGNALEELRPGTFGALGALA 161
Query: 248 VLDVGGNCRRCDHAPNPCMECPRHFPQLHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGL 307
L++ N L F L R+ L L ++LS L GL
Sbjct: 162 TLNLAHNA----------------LVYLPAMAFQGLLRVRWLRLSHNALSVLAPEALAGL 205
Query: 308 GNLRVLDLSENFLYKCITKTKAFQG--LTQLR---KLNLSFNYQKRVSFAHLSLAPSFGS 362
LR L L N L +A G L+Q R +L L N P
Sbjct: 206 PALRRLSLHHNEL-------QALPGPVLSQARGLARLELGHNPLTYAGEEDGLALPGLRE 258
Query: 363 LV----ALKELD---------MHGIFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQLG 409
L+ AL+ L +H + R TL PL L+ LRLQ N +
Sbjct: 259 LLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTLPPLQGPGQLRRLRLQGNPLWCG--- 315
Query: 410 IFRAFPGLRYVDLSDNRISGASELTATM-GEADGGEKVW--LQPGD-------------- 452
+A P L ++ + R GA + + GEA + W PGD
Sbjct: 316 -CQARPLLEWLARARVRSDGACQGPRRLRGEALDALRPWDLRCPGDAAQEEEELEERAVA 374
Query: 453 ------------------LAPAP---VDTPSSEDFRPNCSTLNFT------------LDL 479
+AP P V P S +C LDL
Sbjct: 375 GPRAPPRGPPRGPGEERAVAPCPRACVCVPESR--HSSCEGCGLQAVPRGFPSDTQLLDL 432
Query: 480 SRNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLYHEH 539
RN+ +V F L HL L L H I++ G+ L L L LS N+L
Sbjct: 433 RRNHFPSVPRAAFPGLGHLVSLHLQHCGIAELEAGA-LAGLGRLIYLYLSDNQLAGLSAA 491
Query: 540 SFTELPRLEALDLSYNSQPFGMQGVGHNFSFVAHLRTLRHLSLAHNNIHSQVSQQLCSTS 599
+ PRL L L N +Q G A LR L S
Sbjct: 492 ALEGAPRLGYLYLERNRF---LQVPG------AALRAL--------------------PS 522
Query: 600 LRALDFSGNALGHMWAEGDLYLHFFQGLSGLIWLDLSQNRLHTLLPQTLRNLPKSLQVLR 659
L +L NA+ + A GDL L W+ LS NR+ + L + L+ L
Sbjct: 523 LFSLHLQDNAVDRL-APGDL-----GRTRALRWVYLSGNRITEVSLGAL-GPARELEKLH 575
Query: 660 LRDNYLAFFKWWSLHFLPKLEVLDLAGNQLKALTNGSL-PAGTRLRRLDVSCNSISFVAP 718
L N L +L LP L L L+GN L+AL +G+ P G L+ L ++ + + + P
Sbjct: 576 LDRNQLREVPTGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLFLNSSGLEQICP 635
Query: 719 GFFSK-AKELRELNLSANALKTVDHSWFGPLASALQILDVSANPLHCACGAAFMDFLLEV 777
G FS L+ L+L N L+ + P S L+++D+S+NP HC C LL +
Sbjct: 636 GAFSGLGPGLQSLHLQKNQLRALPAL---PSLSQLELIDLSSNPFHCDCQ------LLPL 686
Query: 778 QAAVPGLPSRV--KCGSPGQLQGLSIFA 803
+ GL RV C +P +G + A
Sbjct: 687 HRWLTGLNLRVGATCATPPNARGQRVKA 714
Score = 61.6 bits (148), Expect = 4e-09
Identities = 63/201 (31%), Positives = 88/201 (43%), Gaps = 31/201 (15%)
Query: 63 GNVTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCPPVGLSPMHFPCHMTIEPSTFLAV 122
G + L+L+SN + L L SLR L L+ N + P TF A+
Sbjct: 110 GRLLLLNLASNHLRELPQEALDGLGSLRRLELEGNALE------------ELRPGTFGAL 157
Query: 123 PTLEELNLSYNNIMTVPALP-KSLIS---LSLSHTNILMLDSASLAGLHALRFLFMDGNC 178
L LNL++N ++ +PA+ + L+ L LSH + +L +LAGL ALR L + N
Sbjct: 158 GALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVLAPEALAGLPALRRLSLHHN- 216
Query: 179 YYKNPCRQALEVAPGALLGLG-NLTHLSLKYNNLTVVPRN----LPSSLEYLLLSYNRIV 233
L+ PG +L L L L +N LT LP L LLL +
Sbjct: 217 --------ELQALPGPVLSQARGLARLELGHNPLTYAGEEDGLALP-GLRELLLDGGALQ 267
Query: 234 KLAPEDLANLTALRVLDVGGN 254
L P A+ L LD+ GN
Sbjct: 268 ALGPRAFAHCPRLHTLDLRGN 288
Score = 55.1 bits (131), Expect = 3e-07
Identities = 82/283 (28%), Positives = 112/283 (39%), Gaps = 64/283 (22%)
Query: 111 HMTIEPSTFLAVPT-----LEELNLSYNNIMTVP--ALPK--SLISLSLSHTNILMLDSA 161
H + E AVP + L+L N+ +VP A P L+SL L H I L++
Sbjct: 408 HSSCEGCGLQAVPRGFPSDTQLLDLRRNHFPSVPRAAFPGLGHLVSLHLQHCGIAELEAG 467
Query: 162 SLAGLHALRFLFMDGNCYYKNPCRQALEVAPGALLGLGNLTHLSLKYNNLTVVP----RN 217
+LAGL L +L++ N Q ++ AL G L +L L+ N VP R
Sbjct: 468 ALAGLGRLIYLYLSDN--------QLAGLSAAALEGAPRLGYLYLERNRFLQVPGAALRA 519
Query: 218 LPSSLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGNCRRCDHAPNPCMECPRHFPQLHP 277
LP SL L L N + +LAP DL ALR + + GN R + R +LH
Sbjct: 520 LP-SLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGN--RITEVSLGALGPARELEKLHL 576
Query: 278 D----------------------------------TFSHLSR-LEGLVLKDSSLSWLNAS 302
D F + R L+ L L S L +
Sbjct: 577 DRNQLREVPTGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLFLNSSGLEQICPG 636
Query: 303 WFRGLG-NLRVLDLSENFLYKCITKTKAFQGLTQLRKLNLSFN 344
F GLG L+ L L +N L A L+QL ++LS N
Sbjct: 637 AFSGLGPGLQSLHLQKNQL----RALPALPSLSQLELIDLSSN 675
Score = 48.1 bits (113), Expect = 4e-05
Identities = 88/317 (27%), Positives = 122/317 (38%), Gaps = 52/317 (16%)
Query: 578 RHLSLAHNNIHSQVSQQLCSTSLRALDFSGNALGHMWAEGDLYLHFFQGLSGLIWLDLSQ 637
RH++ + N+ ++V + + R LD GN L + A FQG+ L LDL
Sbjct: 44 RHVACRYQNL-TEVPDAIPELTQR-LDLQGNLLKVIPAAA------FQGVPHLTHLDLRH 95
Query: 638 NRLHTLLPQTLRNLPKSLQVLRLRDNYLAFFKWWSLHFLPKLEVLDLAGNQLKALTNGS- 696
+ + R L + L +L L N+L +L L L L+L GN L+ L G+
Sbjct: 96 CEVELVAEGAFRGLGRLL-LLNLASNHLRELPQEALDGLGSLRRLELEGNALEELRPGTF 154
Query: 697 ------------------LPAGT-----RLRRLDVSCNSISFVAPGFFSKAKELRELNLS 733
LPA R+R L +S N++S +AP + LR L+L
Sbjct: 155 GALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVLAPEALAGLPALRRLSLH 214
Query: 734 ANALKTVDHSWFGPL---ASALQILDVSANPLHCACGAAFMDFLLEVQAAVPGLPSRVKC 790
N L+ + GP+ A L L++ NPL A E A+PGL +
Sbjct: 215 HNELQALP----GPVLSQARGLARLELGHNPLTYAGE--------EDGLALPGLRELLLD 262
Query: 791 GSPGQLQGLSIFAQDLRLCLDEALSWDCFALSLLAVALGLGVPMLHHLCGWDLWYCFHLC 850
G Q G FA RL L L L G G L G LW C
Sbjct: 263 GGALQALGPRAFAHCPRL---HTLDLRGNQLDTLPPLQGPGQLRRLRLQGNPLW-CGCQA 318
Query: 851 LAWLPWRGRQSGRDEDA 867
L W R R + A
Sbjct: 319 RPLLEWLARARVRSDGA 335
>gi|157426829 leucine rich repeat and Ig domain containing 3 [Homo
sapiens]
Length = 592
Score = 92.8 bits (229), Expect = 1e-18
Identities = 102/362 (28%), Positives = 157/362 (43%), Gaps = 54/362 (14%)
Query: 448 LQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLSRNNLVTVQPEMFAQLSHLQCLRLSHNC 507
L PGDLA P + E+ LDLS N + V+P FA L L+ LRL N
Sbjct: 69 LNPGDLAALP----ALEE-----------LDLSENAIAHVEPGAFANLPRLRVLRLRGNQ 113
Query: 508 ISQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEALDLSYNSQPFGMQGVGHN 567
+ G F L L +LDLS NKL + +++F +L L L++ N F +
Sbjct: 114 LKLIPPGV-FTRLDNLTLLDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRA--- 169
Query: 568 FSFVAHLRTLRHLSLAHNNIHSQVSQQLCSTSLRALDFSGNALGHMWAEGDLYLHF---- 623
A L L L+L N+ + SG +LGH+ + G L L
Sbjct: 170 ---FAGLLALEELTLERCNLTA---------------LSGESLGHLRSLGALRLRHLAIA 211
Query: 624 ------FQGLSGLIWLDLSQ-NRLHTLLPQTLRNLPKSLQVLRLRDNYLAFFKWWSLHFL 676
F+ L GL+ L++ L + +LR L +L L + + +L
Sbjct: 212 SLEDQNFRRLPGLLHLEIDNWPLLEEVAAGSLRGL--NLTSLSVTHTNITAVPAAALRHQ 269
Query: 677 PKLEVLDLAGNQLKALTNGSLPAGTRLRRLDVSCNSISFVAPGFFSKAKELRELNLSANA 736
L L+L+ N + + GS RLR L ++ ++ V P F +++R LNLS N
Sbjct: 270 AHLTCLNLSHNPISTVPRGSFRDLVRLRELHLAGALLAVVEPQAFLGLRQIRLLNLSNNL 329
Query: 737 LKTVDHSWFGPLASALQILDVSANPLHCACGAAFMDFLLEVQAAVPGLPSRVKCGSPGQL 796
L T++ S F + + L+ L V NPL C C ++ + LP+ C +P ++
Sbjct: 330 LSTLEESTFHSV-NTLETLRVDGNPLACDCRLLWIVQRRKTLNFDGRLPA---CATPAEV 385
Query: 797 QG 798
+G
Sbjct: 386 RG 387
Score = 91.7 bits (226), Expect = 3e-18
Identities = 102/346 (29%), Positives = 142/346 (41%), Gaps = 63/346 (18%)
Query: 211 LTVVPRNLPSSLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGNCRRCDHAPNPCMECPR 270
LT VP +P+ L LS NRI L P DLA L AL LD+ N
Sbjct: 45 LTAVPDGIPAETRLLELSRNRIRCLNPGDLAALPALEELDLSENA--------------- 89
Query: 271 HFPQLHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSENFLYKCITKTKAF 330
+ P F++L RL L L+ + L + F L NL +LDLSEN L + T F
Sbjct: 90 -IAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLSENKLVILLDYT--F 146
Query: 331 QGLTQLRKLNLSFNYQKRVSFAHLSLAPSFGSLVALKELDMHGIFFRSLDETTLRPLARL 390
Q L LR+L + N VS +F L+AL+EL + +L + L L
Sbjct: 147 QDLHSLRRLEVGDNDLVFVS------RRAFAGLLALEELTLERCNLTALSGES---LGHL 197
Query: 391 PMLQTLRLQMNFINQAQLGIFRAFPGLRYVDLSDNRISGASELTATMGEADGGEKVWLQP 450
L LRL+ I + FR PGL ++++ + W
Sbjct: 198 RSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDN----------------------WPLL 235
Query: 451 GDLAPAPVDTPSSEDFRPNCSTLNFT-LDLSRNNLVTVQPEMFAQLSHLQCLRLSHNCIS 509
++A + LN T L ++ N+ V +HL CL LSHN IS
Sbjct: 236 EEVAAG------------SLRGLNLTSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPIS 283
Query: 510 QAVNGSQFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEALDLSYN 555
GS F L L+ L L+ L + +F L ++ L+LS N
Sbjct: 284 TVPRGS-FRDLVRLRELHLAGALLAVVEPQAFLGLRQIRLLNLSNN 328
Score = 65.1 bits (157), Expect = 3e-10
Identities = 92/335 (27%), Positives = 131/335 (39%), Gaps = 46/335 (13%)
Query: 27 GTLPAFLPCELQPHGLVNCNWLFLKSVPHFSMAAPRGNVTSLSLSSNRIHHLHDSDFAHL 86
G PA C +Q V C L +VP A R L LS NRI L+ D A L
Sbjct: 23 GGCPARCECTVQTRA-VACTRRRLTAVPDGIPAETR----LLELSRNRIRCLNPGDLAAL 77
Query: 87 PSLRHLNLKWNCPPVGLSPMHFPCHMTIEPSTFLAVPTLEELNLSYNNIMTVP----ALP 142
P+L L+L N +EP F +P L L L N + +P
Sbjct: 78 PALEELDLSEN------------AIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRL 125
Query: 143 KSLISLSLSHTNILMLDSASLAGLHALRFLFMDGNCYYKNPCRQALEVAPGALLGLGNLT 202
+L L LS +++L + LH+LR L + N + V+ A GL L
Sbjct: 126 DNLTLLDLSENKLVILLDYTFQDLHSLRRLEVGDN--------DLVFVSRRAFAGLLALE 177
Query: 203 HLSLKYNNLTVVPRNLPS---SLEYLLLSYNRIVKLAPEDLANLTALRVLDV-------- 251
L+L+ NLT + SL L L + I L ++ L L L++
Sbjct: 178 ELTLERCNLTALSGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNWPLLEE 237
Query: 252 --GGNCRRCDHAPNPCMECPRHFPQLHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGN 309
G+ R + + + H + L L L + +S + FR L
Sbjct: 238 VAAGSLRGLNLTSLSVTH--TNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVR 295
Query: 310 LRVLDLSENFLYKCITKTKAFQGLTQLRKLNLSFN 344
LR L L+ L + + +AF GL Q+R LNLS N
Sbjct: 296 LRELHLAGALL--AVVEPQAFLGLRQIRLLNLSNN 328
Score = 52.0 bits (123), Expect = 3e-06
Identities = 34/92 (36%), Positives = 48/92 (52%), Gaps = 1/92 (1%)
Query: 681 VLDLAGNQLKALTNGSLPAGTRLRRLDVSCNSISFVAPGFFSKAKELRELNLSANALKTV 740
+L+L+ N+++ L G L A L LD+S N+I+ V PG F+ LR L L N LK +
Sbjct: 58 LLELSRNRIRCLNPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLI 117
Query: 741 DHSWFGPLASALQILDVSANPLHCACGAAFMD 772
F L + L +LD+S N L F D
Sbjct: 118 PPGVFTRLDN-LTLLDLSENKLVILLDYTFQD 148
Score = 50.4 bits (119), Expect = 8e-06
Identities = 83/313 (26%), Positives = 120/313 (38%), Gaps = 36/313 (11%)
Query: 361 GSLVALKELDMHGIFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYV 420
G L AL L+ + ++ A LP L+ LRL+ N + G+F L +
Sbjct: 72 GDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTLL 131
Query: 421 DLSDNRISGASELTATMGEADGGEKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLS 480
DLS+N++ L T + ++ + DL S F + TL+
Sbjct: 132 DLSENKL--VILLDYTFQDLHSLRRLEVGDNDLV-----FVSRRAFAGLLALEELTLE-- 182
Query: 481 RNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHS 540
R NL + E L L LRL H I+ ++ F L GL L L + L E +
Sbjct: 183 RCNLTALSGESLGHLRSLGALRLRHLAIA-SLEDQNFRRLPGL--LHLEIDNWPLLEEVA 239
Query: 541 FTELPRLEALDLSYNSQPFGMQGVGHNFSFVAHLRTLRH------LSLAHNNIHSQVSQQ 594
L L LS V H LRH L+L+HN I +
Sbjct: 240 AGSLRGLNLTSLS----------VTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGS 289
Query: 595 LCS-TSLRALDFSGNALGHMWAEGDLYLHFFQGLSGLIWLDLSQNRLHTLLPQTLRNLPK 653
LR L +G L + + F GL + L+LS N L TL T ++
Sbjct: 290 FRDLVRLRELHLAGALLAVVEPQA------FLGLRQIRLLNLSNNLLSTLEESTFHSV-N 342
Query: 654 SLQVLRLRDNYLA 666
+L+ LR+ N LA
Sbjct: 343 TLETLRVDGNPLA 355
Score = 47.0 bits (110), Expect = 9e-05
Identities = 39/124 (31%), Positives = 56/124 (45%), Gaps = 1/124 (0%)
Query: 651 LPKSLQVLRLRDNYLAFFKWWSLHFLPKLEVLDLAGNQLKALTNGSLPAGTRLRRLDVSC 710
+P ++L L N + L LP LE LDL+ N + + G+ RLR L +
Sbjct: 52 IPAETRLLELSRNRIRCLNPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRG 111
Query: 711 NSISFVAPGFFSKAKELRELNLSANALKTVDHSWFGPLASALQILDVSANPLHCACGAAF 770
N + + PG F++ L L+LS N L + F L S L+ L+V N L AF
Sbjct: 112 NQLKLIPPGVFTRLDNLTLLDLSENKLVILLDYTFQDLHS-LRRLEVGDNDLVFVSRRAF 170
Query: 771 MDFL 774
L
Sbjct: 171 AGLL 174
Score = 37.0 bits (84), Expect = 0.096
Identities = 64/250 (25%), Positives = 90/250 (36%), Gaps = 73/250 (29%)
Query: 64 NVTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCPPVGLSPMHFPCHMTIEPSTFLAVP 123
N+T L LS N++ L D F L SLR L VG + + F + F +
Sbjct: 127 NLTLLDLSENKLVILLDYTFQDLHSLRRLE-------VGDNDLVF-----VSRRAFAGLL 174
Query: 124 TLEELNLSYNNIMTVPALP----KSLISLSLSHTNILMLDSASLAGLHALRFLFMDGNCY 179
LEEL L N+ + +SL +L L H I L+ + L L L +D
Sbjct: 175 ALEELTLERCNLTALSGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNWPL 234
Query: 180 YKNPCRQALEVAPGALLGLG-----------------------NLTHLSLKYNNLTVVPR 216
+ EVA G+L GL +LT L+L +N ++ VPR
Sbjct: 235 LE-------EVAAGSLRGLNLTSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPR 287
Query: 217 ------------NLPSSL---------------EYLLLSYNRIVKLAPEDLANLTALRVL 249
+L +L L LS N + L ++ L L
Sbjct: 288 GSFRDLVRLRELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETL 347
Query: 250 DVGGNCRRCD 259
V GN CD
Sbjct: 348 RVDGNPLACD 357
>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
isoform 2 [Homo sapiens]
Length = 1119
Score = 87.0 bits (214), Expect = 8e-17
Identities = 114/436 (26%), Positives = 188/436 (43%), Gaps = 79/436 (18%)
Query: 313 LDLSENFLYKCITKTKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSFGSLVALKELDMH 372
LDLS N L K + L LR++ L+ N L P+ G + A + +
Sbjct: 79 LDLSHNRL--SFIKASSMSHLQSLREVKLNNN--------ELETIPNLGPVSA--NITLL 126
Query: 373 GIFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGL--RYVDLSDNRISGA 430
+ + E L L+TL L N I++ Q AFP L +Y+ L+ NR++
Sbjct: 127 SLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQT----AFPALQLKYLYLNSNRVTS- 181
Query: 431 SELTATMGEADGGEKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLSRNNLVTVQPE 490
++PG + N + L L+RN + + P+
Sbjct: 182 -----------------MEPG--------------YFDNLANTLLVLKLNRNRISAIPPK 210
Query: 491 MFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEAL 550
MF +L LQ L L+ N I V+G F L L+ L + N + + +F L +E L
Sbjct: 211 MF-KLPQLQHLELNRNKIKN-VDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEIL 268
Query: 551 DLSYNSQPFGMQGVGHNFSFVAHLRTLRHLSLAHNNIH--SQVSQQLCSTSLRALDFSGN 608
L +N+ +G ++ L L+ L L+ N I+ S + + C L LD + N
Sbjct: 269 QLDHNNLTEITKG------WLYGLLMLQELHLSQNAINRISPDAWEFCQ-KLSELDLTFN 321
Query: 609 ALGHMWAEGDLYLHFFQGLSGLIWLDLSQNRLHTLLPQTLRNLPKSLQVLRLRDNYLAFF 668
L + F GLS L L + NR+ + R L SL+ L L++N ++
Sbjct: 322 HLSRLDDSS------FLGLSLLNTLHIGNNRVSYIADCAFRGL-SSLKTLDLKNNEIS-- 372
Query: 669 KWWSLHF-------LPKLEVLDLAGNQLKALTNGSLPAGTRLRRLDVSCNSISFVAPGFF 721
W++ L KL L L GN+++++T + L LD+S N+I + F
Sbjct: 373 --WTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAF 430
Query: 722 SKAKELRELNLSANAL 737
S+ K+L++L+L+ ++L
Sbjct: 431 SQMKKLQQLHLNTSSL 446
Score = 84.3 bits (207), Expect = 5e-16
Identities = 101/363 (27%), Positives = 156/363 (42%), Gaps = 52/363 (14%)
Query: 50 LKSVPHFSMAAPRGNVTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWN--------CPPV 101
L+++P+ + N+T LSL+ NRI + SL L+L N P +
Sbjct: 110 LETIPNLGPVS--ANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQTAFPAL 167
Query: 102 GLSPMHFPCHM--TIEPSTFLAVP-TLEELNLSYNNIMTVPA----LPKSLISLSLSHTN 154
L ++ + ++EP F + TL L L+ N I +P LP+ L L L+
Sbjct: 168 QLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQ-LQHLELNRNK 226
Query: 155 ILMLDSASLAGLHALRFLFMDGNCYYKNPCRQALEVAPGALLGLGNLTHLSLKYNNLTVV 214
I +D + GL AL+ L M N K + GA GL N+ L L +NNLT +
Sbjct: 227 IKNVDGLTFQGLGALKSLKMQRNGVTK--------LMDGAFWGLSNMEILQLDHNNLTEI 278
Query: 215 PRNLPSSL---EYLLLSYNRIVKLAPEDLANLTALRVLDVGGNCRRCDHAPNPCMECPRH 271
+ L + L LS N I +++P+ L LD+ N H
Sbjct: 279 TKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFN----------------H 322
Query: 272 FPQLHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSENFLYKCITKTK-AF 330
+L +F LS L L + ++ +S++ FRGL +L+ LDL N + I AF
Sbjct: 323 LSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAF 382
Query: 331 QGLTQLRKLNLSFNYQKRVSFAHLSLAPSFGSLVALKELDMHGIFFRSLDETTLRPLARL 390
GL +LR+L L N + ++ +F L AL+ LD+ SL + +L
Sbjct: 383 SGLDKLRRLILQGNRIRSIT------KKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKL 436
Query: 391 PML 393
L
Sbjct: 437 QQL 439
Score = 80.1 bits (196), Expect = 1e-14
Identities = 102/405 (25%), Positives = 173/405 (42%), Gaps = 48/405 (11%)
Query: 128 LNLSYNNIMTVPA-LPKSLISLSLSHTNILMLDSASLAGLHALRFLFMDGNCYYKNP--- 183
L+ S + +P LP + L LSH + + ++S++ L +LR + ++ N P
Sbjct: 58 LDCSRKRLARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLG 117
Query: 184 ------------CRQALEVAPGALLGLGNLTHLSLKYNNLTVVPRNLPS-SLEYLLLSYN 230
+ +E+ P L +L L L NN++ + P+ L+YL L+ N
Sbjct: 118 PVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQTAFPALQLKYLYLNSN 177
Query: 231 RIVKLAPEDLANL-TALRVLDVGGNCRRCDHAPNPCMECPR---------HFPQLHPDTF 280
R+ + P NL L VL + N R P + P+ + TF
Sbjct: 178 RVTSMEPGYFDNLANTLLVLKLNRN--RISAIPPKMFKLPQLQHLELNRNKIKNVDGLTF 235
Query: 281 SHLSRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSENFLYKCITKTKAFQGLTQLRKLN 340
L L+ L ++ + ++ L F GL N+ +L L N L + ITK + GL L++L+
Sbjct: 236 QGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTE-ITKGWLY-GLLMLQELH 293
Query: 341 LSFNYQKRVSFAHLSLAPSFGSLVALKELDMHGIFFRSLDETTLRPLARLPMLQTLRLQM 400
LS N R+S ++ L ELD+ LD+++ L+ +L TL +
Sbjct: 294 LSQNAINRIS------PDAWEFCQKLSELDLTFNHLSRLDDSSFLGLS---LLNTLHIGN 344
Query: 401 NFINQAQLGIFRAFPGLRYVDLSDNRISGASE-LTATMGEADGGEKVWLQPGDLAPAPVD 459
N ++ FR L+ +DL +N IS E + D ++ LQ +
Sbjct: 345 NRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKK 404
Query: 460 TPSSEDFRPNCSTLNFTLDLSRNNLVTVQPEMFAQLSHLQCLRLS 504
+ D + LDLS N ++++Q F+Q+ LQ L L+
Sbjct: 405 AFTGLDALEH-------LDLSDNAIMSLQGNAFSQMKKLQQLHLN 442
Score = 60.1 bits (144), Expect = 1e-08
Identities = 103/424 (24%), Positives = 176/424 (41%), Gaps = 66/424 (15%)
Query: 198 LGNLTHLSLKYNNLTVVPRNLPSSLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGNCRR 257
LG+L S K L +P LPS + L LS+NR+ + +++L +LR + + N
Sbjct: 54 LGDLLDCSRK--RLARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVKLNNN--E 109
Query: 258 CDHAPN--PCME-------CPRHFPQLHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLG 308
+ PN P ++ P+ LE L L +++S L + F L
Sbjct: 110 LETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQTA-FPAL- 167
Query: 309 NLRVLDLSENFLYKCITKTKAFQGLTQ-LRKLNLSFNYQKRVSFAHLSLAPSFGSLVALK 367
L+ L L+ N + + F L L L L+ N R+S ++ P L L+
Sbjct: 168 QLKYLYLNSNRVTS--MEPGYFDNLANTLLVLKLNRN---RIS----AIPPKMFKLPQLQ 218
Query: 368 ELDMHGIFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYVDLSDNRI 427
L+++ +++D T + L L++L++Q N + + G F + + L N +
Sbjct: 219 HLELNRNKIKNVDGLTFQGLG---ALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNL 275
Query: 428 SGASELTATMGEADGGEKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLSRNNLVTV 487
+E+T K WL + L LS+N + +
Sbjct: 276 ---TEIT----------KGWLYG--------------------LLMLQELHLSQNAINRI 302
Query: 488 QPEMFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHSFTELPRL 547
P+ + L L L+ N +S+ ++ S FL L+ L L + +N++ + +F L L
Sbjct: 303 SPDAWEFCQKLSELDLTFNHLSR-LDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSL 361
Query: 548 EALDLSYNSQPFGMQGVGHNFSFVAHLRTLRHLSLAHNNIHSQVSQQLCS-TSLRALDFS 606
+ LDL N + ++ + FS L LR L L N I S + +L LD S
Sbjct: 362 KTLDLKNNEISWTIEDMNGAFS---GLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLS 418
Query: 607 GNAL 610
NA+
Sbjct: 419 DNAI 422
Score = 57.8 bits (138), Expect = 5e-08
Identities = 76/303 (25%), Positives = 137/303 (45%), Gaps = 35/303 (11%)
Query: 477 LDLSRNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKL-DL 535
LDLS N L ++ + L L+ ++L++N + N + +L L+ N++ ++
Sbjct: 79 LDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVS--ANITLLSLAGNRIVEI 136
Query: 536 YHEHSFTELPRLEALDLSYNSQPFGMQGVGHNFSFVAHLRT------LRHLSLAHNNIHS 589
EH E LE LDLS N+ ++ L+T L++L L N + S
Sbjct: 137 LPEH-LKEFQSLETLDLSSNN--------------ISELQTAFPALQLKYLYLNSNRVTS 181
Query: 590 QVSQQL--CSTSLRALDFSGNALGHMWAEGDLYLHFFQGLSGLIWLDLSQNRLHTLLPQT 647
+ +L L + N + + + F+ L L L+L++N++ + T
Sbjct: 182 MEPGYFDNLANTLLVLKLNRNRISAIPPK------MFK-LPQLQHLELNRNKIKNVDGLT 234
Query: 648 LRNLPKSLQVLRLRDNYLAFFKWWSLHFLPKLEVLDLAGNQLKALTNGSLPAGTRLRRLD 707
+ L +L+ L+++ N + + L +E+L L N L +T G L L+ L
Sbjct: 235 FQGLG-ALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELH 293
Query: 708 VSCNSISFVAPGFFSKAKELRELNLSANALKTVDHSWFGPLASALQILDVSANPLHCACG 767
+S N+I+ ++P + ++L EL+L+ N L +D S F L S L L + N +
Sbjct: 294 LSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGL-SLLNTLHIGNNRVSYIAD 352
Query: 768 AAF 770
AF
Sbjct: 353 CAF 355
Score = 42.0 bits (97), Expect = 0.003
Identities = 45/151 (29%), Positives = 71/151 (47%), Gaps = 29/151 (19%)
Query: 633 LDLSQNRLHTLLPQTLRNLPKSLQVLRLRDNYLAFFKWWSLHFLPKLEVLDLAGNQLKAL 692
LD S+ RL LP+ L P + L L N L+F K S+ L L + L N+L+ +
Sbjct: 58 LDCSRKRL-ARLPEPL---PSWVARLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETI 113
Query: 693 TN-GSLP--------AGTR--------------LRRLDVSCNSISFVAPGFFSKAKELRE 729
N G + AG R L LD+S N+IS + F A +L+
Sbjct: 114 PNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQTAF--PALQLKY 171
Query: 730 LNLSANALKTVDHSWFGPLASALQILDVSAN 760
L L++N + +++ +F LA+ L +L ++ N
Sbjct: 172 LYLNSNRVTSMEPGYFDNLANTLLVLKLNRN 202
Score = 40.4 bits (93), Expect = 0.009
Identities = 24/78 (30%), Positives = 42/78 (53%), Gaps = 2/78 (2%)
Query: 683 DLAGNQLKALTNGSLPAGTRLRRLDVSCNSISFVAPGFFSKAKELRELNLSANALKTVDH 742
DL K L P + + RLD+S N +SF+ S + LRE+ L+ N L+T+ +
Sbjct: 56 DLLDCSRKRLARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPN 115
Query: 743 SWFGPLASALQILDVSAN 760
GP+++ + +L ++ N
Sbjct: 116 --LGPVSANITLLSLAGN 131
Score = 40.0 bits (92), Expect = 0.011
Identities = 54/224 (24%), Positives = 87/224 (38%), Gaps = 40/224 (17%)
Query: 63 GNVTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCPPVGLSPMHFPCHMT-IEPSTFLA 121
G + SL + N + L D F L ++ L L N ++T I
Sbjct: 239 GALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHN-------------NLTEITKGWLYG 285
Query: 122 VPTLEELNLSYNNIMTVPA----LPKSLISLSLSHTNILMLDSASLAGLHALRFLFMDGN 177
+ L+EL+LS N I + + L L L+ ++ LD +S GL L L + N
Sbjct: 286 LLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNN 345
Query: 178 -------CYYK------------NPCRQALEVAPGALLGLGNLTHLSLKYNNLTVVPRNL 218
C ++ N +E GA GL L L L+ N + + +
Sbjct: 346 RVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKA 405
Query: 219 PS---SLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGNCRRCD 259
+ +LE+L LS N I+ L + + L+ L + + CD
Sbjct: 406 FTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCD 449
>gi|76880480 hypothetical protein LOC9865 [Homo sapiens]
Length = 811
Score = 85.9 bits (211), Expect = 2e-16
Identities = 120/419 (28%), Positives = 170/419 (40%), Gaps = 72/419 (17%)
Query: 11 LSLLVQAIMLAMTLALGTLPAFLPCELQPHGLVNCNWLFLKSVPHFSMAAPRGNVTSLSL 70
L L+V + LA P C+ H L C L+ VP S +V + SL
Sbjct: 9 LLLVVCGCLALPPLAEPVCPERCDCQHPQHLL--CTNRGLRVVPKTSSLPSPHDVLTYSL 66
Query: 71 SSNRIHHLHDSDFAHLPSLRHLNLKWNCPPVGLSPMHFPCHMTIEPSTFLAVPTLEELNL 130
N I ++ DF L LR L+L++N + +H P TF + LEEL L
Sbjct: 67 GGNFITNITAFDFHRLGQLRRLDLQYN----QIRSLH--------PKTFEKLSRLEELYL 114
Query: 131 SYNNIMTVPALPKSLISLSLSHTNILMLDSASLAGLHALRFLFMDGNCYYKNPCRQALEV 190
NN++ L +LA L LR L+ +GN + +
Sbjct: 115 G-NNLLQA-------------------LAPGTLAPLRKLRILYANGN--------EISRL 146
Query: 191 APGALLGLGNLTHLSLKYNNLTVVPRNLPS---SLEYLLLSYNRIVKLAPEDLANLTALR 247
+ G+ GL +L L L N L +P + + +L YL L NRI L A L LR
Sbjct: 147 SRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLHLESNRIRFLGKNAFAQLGKLR 206
Query: 248 VLDVGGNCRRCDHAPNPCMECPRHFPQL-HPDTFSHLSRLEGLVLKDSSLSWLNASWFRG 306
L++ N + P L H TF+ L L L+L ++L L F+
Sbjct: 207 FLNLSANELQ---------------PSLRHAATFAPLRSLSSLILSANNLQHLGPRIFQH 251
Query: 307 LGNLRVLDLSENFLYKCITKTKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSFGSLVAL 366
L L +L L N L +AF GL LR+L L N ++ A L L +L
Sbjct: 252 LPRLGLLSLRGNQLTH--LAPEAFWGLEALRELRLEGNRLSQLPTALLE------PLHSL 303
Query: 367 KELDMHGIFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYVDLSDN 425
+ LD+ G +L T L R L+ L L+ N ++ IF A P L +DL N
Sbjct: 304 EALDLSGNELSALHPATFGHLGR---LRELSLRNNALSALSGDIFAASPALYRLDLDGN 359
Score = 80.9 bits (198), Expect = 6e-15
Identities = 96/332 (28%), Positives = 143/332 (43%), Gaps = 41/332 (12%)
Query: 477 LDLSRNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLY 536
LDL N + ++ P+ F +LS L+ L L +N + QA+ PL L++L + N++
Sbjct: 88 LDLQYNQIRSLHPKTFEKLSRLEELYLGNNLL-QALAPGTLAPLRKLRILYANGNEISRL 146
Query: 537 HEHSFTELPRLEALDLSYNS---------QPFG-----------MQGVGHNFSFVAHLRT 576
SF L L L L N+ P G ++ +G N A L
Sbjct: 147 SRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLHLESNRIRFLGKNA--FAQLGK 204
Query: 577 LRHLSLAHNNIHSQVSQQLCSTSLRALD---FSGNALGHMWAEGDLYLHFFQGLSGLIWL 633
LR L+L+ N + + LR+L S N L H+ FQ L L L
Sbjct: 205 LRFLNLSANELQPSLRHAATFAPLRSLSSLILSANNLQHLGPR------IFQHLPRLGLL 258
Query: 634 DLSQNRLHTLLPQTLRNLPKSLQVLRLRDNYLAFFKWWSLHFLPKLEVLDLAGNQLKALT 693
L N+L L P+ L ++L+ LRL N L+ L L LE LDL+GN+L AL
Sbjct: 259 SLRGNQLTHLAPEAFWGL-EALRELRLEGNRLSQLPTALLEPLHSLEALDLSGNELSALH 317
Query: 694 NGSLPAGTRLRRLDVSCNSISFVAPGFFSKAKELRELNLSANALKTVD------HSWFGP 747
+ RLR L + N++S ++ F+ + L L+L N T D W G
Sbjct: 318 PATFGHLGRLRELSLRNNALSALSGDIFAASPALYRLDLDGNGW-TCDCRLRGLKRWMGD 376
Query: 748 LASALQILDVSANPLH-CACGAAFMDFLLEVQ 778
S ++L V H A ++D+L + Q
Sbjct: 377 WHSQGRLLTVFVQCRHPPALRGKYLDYLDDQQ 408
Score = 69.3 bits (168), Expect = 2e-11
Identities = 103/362 (28%), Positives = 137/362 (37%), Gaps = 57/362 (15%)
Query: 451 GDLAPAPVDTPSSEDFRPNCSTLNFTLDLSRNNLVTVQPEMFAQLSHLQCLRLSHNCISQ 510
G LA P+ P + R +C L +R V + + L N I+
Sbjct: 15 GCLALPPLAEPVCPE-RCDCQHPQHLLCTNRGLRVVPKTSSLPSPHDVLTYSLGGNFITN 73
Query: 511 AVNGSQFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEALDLSYNSQPFGMQGVGHNFSF 570
+ F L L+ LDL +N++ H +F +L RLE L L N G
Sbjct: 74 -ITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGT------ 126
Query: 571 VAHLRTLRHLSLAHNNIHSQVSQQLCS--TSLRALDFSGNALGHM------WAEGDLYLH 622
+A LR LR L A+ N S++S+ SL L GNALG + LYLH
Sbjct: 127 LAPLRKLRIL-YANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLH 185
Query: 623 F--------------------------------------FQGLSGLIWLDLSQNRLHTLL 644
F L L L LS N L L
Sbjct: 186 LESNRIRFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSANNLQHLG 245
Query: 645 PQTLRNLPKSLQVLRLRDNYLAFFKWWSLHFLPKLEVLDLAGNQLKALTNGSLPAGTRLR 704
P+ ++LP+ L +L LR N L + L L L L GN+L L L L
Sbjct: 246 PRIFQHLPR-LGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPLHSLE 304
Query: 705 RLDVSCNSISFVAPGFFSKAKELRELNLSANALKTVDHSWFGPLASALQILDVSANPLHC 764
LD+S N +S + P F LREL+L NAL + F + AL LD+ N C
Sbjct: 305 ALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFA-ASPALYRLDLDGNGWTC 363
Query: 765 AC 766
C
Sbjct: 364 DC 365
Score = 62.0 bits (149), Expect = 3e-09
Identities = 76/255 (29%), Positives = 101/255 (39%), Gaps = 34/255 (13%)
Query: 198 LGNLTHLSLKYNNL-TVVPRNLP--SSLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGN 254
LG L L L+YN + ++ P+ S LE L L N + LAP LA L LR+L GN
Sbjct: 82 LGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRKLRILYANGN 141
Query: 255 CRRCDHAPNPCMECPRHFPQLHPD----------TFSHLSRLEGLVLKDSSLSWLNASWF 304
E +L D F+ L L L L+ + + +L + F
Sbjct: 142 --EISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLHLESNRIRFLGKNAF 199
Query: 305 RGLGNLRVLDLSENFLYKCITKTKAFQGLTQLRKLNLSFNYQKRVS---FAHLSLAPSFG 361
LG LR L+LS N L + F L L L LS N + + F HL P G
Sbjct: 200 AQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSANNLQHLGPRIFQHL---PRLG 256
Query: 362 SLVALKELDMHGIFFRSLDETTLRPLA--RLPMLQTLRLQMNFINQAQLGIFRAFPGLRY 419
L R T L P A L L+ LRL+ N ++Q + L
Sbjct: 257 LLS-----------LRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPLHSLEA 305
Query: 420 VDLSDNRISGASELT 434
+DLS N +S T
Sbjct: 306 LDLSGNELSALHPAT 320
Score = 42.7 bits (99), Expect = 0.002
Identities = 39/138 (28%), Positives = 64/138 (46%), Gaps = 4/138 (2%)
Query: 635 LSQNRLHTLLPQTLRNLPKSLQVLR--LRDNYLAFFKWWSLHFLPKLEVLDLAGNQLKAL 692
L NR ++P+T +LP VL L N++ + H L +L LDL NQ+++L
Sbjct: 40 LCTNRGLRVVPKT-SSLPSPHDVLTYSLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSL 98
Query: 693 TNGSLPAGTRLRRLDVSCNSISFVAPGFFSKAKELRELNLSANALKTVDHSWFGPLASAL 752
+ +RL L + N + +APG + ++LR L + N + + F L S +
Sbjct: 99 HPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRKLRILYANGNEISRLSRGSFEGLESLV 158
Query: 753 QILDVSANPLHCACGAAF 770
+ L + N L A F
Sbjct: 159 K-LRLDGNALGALPDAVF 175
>gi|209862903 leucine-rich repeats and immunoglobulin-like domains 3
isoform 1 [Homo sapiens]
Length = 1059
Score = 85.5 bits (210), Expect = 2e-16
Identities = 113/435 (25%), Positives = 187/435 (42%), Gaps = 79/435 (18%)
Query: 314 DLSENFLYKCITKTKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSFGSLVALKELDMHG 373
DLS N L K + L LR++ L+ N L P+ G + A + +
Sbjct: 20 DLSHNRL--SFIKASSMSHLQSLREVKLNNN--------ELETIPNLGPVSA--NITLLS 67
Query: 374 IFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGL--RYVDLSDNRISGAS 431
+ + E L L+TL L N I++ Q AFP L +Y+ L+ NR++
Sbjct: 68 LAGNRIVEILPEHLKEFQSLETLDLSSNNISELQT----AFPALQLKYLYLNSNRVTS-- 121
Query: 432 ELTATMGEADGGEKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLSRNNLVTVQPEM 491
++PG + N + L L+RN + + P+M
Sbjct: 122 ----------------MEPG--------------YFDNLANTLLVLKLNRNRISAIPPKM 151
Query: 492 FAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEALD 551
F +L LQ L L+ N I V+G F L L+ L + N + + +F L +E L
Sbjct: 152 F-KLPQLQHLELNRNKIKN-VDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQ 209
Query: 552 LSYNSQPFGMQGVGHNFSFVAHLRTLRHLSLAHNNIH--SQVSQQLCSTSLRALDFSGNA 609
L +N+ +G ++ L L+ L L+ N I+ S + + C L LD + N
Sbjct: 210 LDHNNLTEITKG------WLYGLLMLQELHLSQNAINRISPDAWEFCQ-KLSELDLTFNH 262
Query: 610 LGHMWAEGDLYLHFFQGLSGLIWLDLSQNRLHTLLPQTLRNLPKSLQVLRLRDNYLAFFK 669
L + F GLS L L + NR+ + R L SL+ L L++N ++
Sbjct: 263 LSRLDDSS------FLGLSLLNTLHIGNNRVSYIADCAFRGL-SSLKTLDLKNNEIS--- 312
Query: 670 WWSLHF-------LPKLEVLDLAGNQLKALTNGSLPAGTRLRRLDVSCNSISFVAPGFFS 722
W++ L KL L L GN+++++T + L LD+S N+I + FS
Sbjct: 313 -WTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFS 371
Query: 723 KAKELRELNLSANAL 737
+ K+L++L+L+ ++L
Sbjct: 372 QMKKLQQLHLNTSSL 386
Score = 84.3 bits (207), Expect = 5e-16
Identities = 101/363 (27%), Positives = 156/363 (42%), Gaps = 52/363 (14%)
Query: 50 LKSVPHFSMAAPRGNVTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWN--------CPPV 101
L+++P+ + N+T LSL+ NRI + SL L+L N P +
Sbjct: 50 LETIPNLGPVS--ANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQTAFPAL 107
Query: 102 GLSPMHFPCHM--TIEPSTFLAVP-TLEELNLSYNNIMTVPA----LPKSLISLSLSHTN 154
L ++ + ++EP F + TL L L+ N I +P LP+ L L L+
Sbjct: 108 QLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQ-LQHLELNRNK 166
Query: 155 ILMLDSASLAGLHALRFLFMDGNCYYKNPCRQALEVAPGALLGLGNLTHLSLKYNNLTVV 214
I +D + GL AL+ L M N K + GA GL N+ L L +NNLT +
Sbjct: 167 IKNVDGLTFQGLGALKSLKMQRNGVTK--------LMDGAFWGLSNMEILQLDHNNLTEI 218
Query: 215 PRNLPSSL---EYLLLSYNRIVKLAPEDLANLTALRVLDVGGNCRRCDHAPNPCMECPRH 271
+ L + L LS N I +++P+ L LD+ N H
Sbjct: 219 TKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFN----------------H 262
Query: 272 FPQLHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSENFLYKCITKTK-AF 330
+L +F LS L L + ++ +S++ FRGL +L+ LDL N + I AF
Sbjct: 263 LSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAF 322
Query: 331 QGLTQLRKLNLSFNYQKRVSFAHLSLAPSFGSLVALKELDMHGIFFRSLDETTLRPLARL 390
GL +LR+L L N + ++ +F L AL+ LD+ SL + +L
Sbjct: 323 SGLDKLRRLILQGNRIRSIT------KKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKL 376
Query: 391 PML 393
L
Sbjct: 377 QQL 379
Score = 72.0 bits (175), Expect = 3e-12
Identities = 110/453 (24%), Positives = 179/453 (39%), Gaps = 97/453 (21%)
Query: 64 NVTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCPPVGLSPMHFPCHMTIEPSTFLAVP 123
+++ LS NR+ + S +HL SLR
Sbjct: 15 HISRPDLSHNRLSFIKASSMSHLQSLR--------------------------------- 41
Query: 124 TLEELNLSYNNIMTVPALPKSLISLSLSHTNILMLDSASLAGLHALRFLFMDGNCYYKNP 183
E+ L+ N + T+P +L NI +L SLAG
Sbjct: 42 ---EVKLNNNELETIP-------NLGPVSANITLL---SLAG------------------ 70
Query: 184 CRQALEVAPGALLGLGNLTHLSLKYNNLTVVPRNLPS-SLEYLLLSYNRIVKLAPEDLAN 242
+ +E+ P L +L L L NN++ + P+ L+YL L+ NR+ + P N
Sbjct: 71 -NRIVEILPEHLKEFQSLETLDLSSNNISELQTAFPALQLKYLYLNSNRVTSMEPGYFDN 129
Query: 243 L-TALRVLDVGGNCRRCDHAPNPCMECPR---------HFPQLHPDTFSHLSRLEGLVLK 292
L L VL + N R P + P+ + TF L L+ L ++
Sbjct: 130 LANTLLVLKLNRN--RISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQ 187
Query: 293 DSSLSWLNASWFRGLGNLRVLDLSENFLYKCITKTKAFQGLTQLRKLNLSFNYQKRVSFA 352
+ ++ L F GL N+ +L L N L + ITK + GL L++L+LS N R+S
Sbjct: 188 RNGVTKLMDGAFWGLSNMEILQLDHNNLTE-ITKGWLY-GLLMLQELHLSQNAINRIS-- 243
Query: 353 HLSLAPSFGSLVALKELDMHGIFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFR 412
++ L ELD+ LD+++ L+ +L TL + N ++ FR
Sbjct: 244 ----PDAWEFCQKLSELDLTFNHLSRLDDSSFLGLS---LLNTLHIGNNRVSYIADCAFR 296
Query: 413 AFPGLRYVDLSDNRISGASE-LTATMGEADGGEKVWLQPGDLAPAPVDTPSSEDFRPNCS 471
L+ +DL +N IS E + D ++ LQ + + D +
Sbjct: 297 GLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEH-- 354
Query: 472 TLNFTLDLSRNNLVTVQPEMFAQLSHLQCLRLS 504
LDLS N ++++Q F+Q+ LQ L L+
Sbjct: 355 -----LDLSDNAIMSLQGNAFSQMKKLQQLHLN 382
Score = 56.2 bits (134), Expect = 2e-07
Identities = 75/302 (24%), Positives = 136/302 (45%), Gaps = 35/302 (11%)
Query: 478 DLSRNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKL-DLY 536
DLS N L ++ + L L+ ++L++N + N + +L L+ N++ ++
Sbjct: 20 DLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVS--ANITLLSLAGNRIVEIL 77
Query: 537 HEHSFTELPRLEALDLSYNSQPFGMQGVGHNFSFVAHLRT------LRHLSLAHNNIHSQ 590
EH E LE LDLS N+ ++ L+T L++L L N + S
Sbjct: 78 PEH-LKEFQSLETLDLSSNN--------------ISELQTAFPALQLKYLYLNSNRVTSM 122
Query: 591 VSQQL--CSTSLRALDFSGNALGHMWAEGDLYLHFFQGLSGLIWLDLSQNRLHTLLPQTL 648
+ +L L + N + + + F+ L L L+L++N++ + T
Sbjct: 123 EPGYFDNLANTLLVLKLNRNRISAIPPK------MFK-LPQLQHLELNRNKIKNVDGLTF 175
Query: 649 RNLPKSLQVLRLRDNYLAFFKWWSLHFLPKLEVLDLAGNQLKALTNGSLPAGTRLRRLDV 708
+ L +L+ L+++ N + + L +E+L L N L +T G L L+ L +
Sbjct: 176 QGLG-ALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHL 234
Query: 709 SCNSISFVAPGFFSKAKELRELNLSANALKTVDHSWFGPLASALQILDVSANPLHCACGA 768
S N+I+ ++P + ++L EL+L+ N L +D S F L S L L + N +
Sbjct: 235 SQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGL-SLLNTLHIGNNRVSYIADC 293
Query: 769 AF 770
AF
Sbjct: 294 AF 295
Score = 40.0 bits (92), Expect = 0.011
Identities = 54/224 (24%), Positives = 87/224 (38%), Gaps = 40/224 (17%)
Query: 63 GNVTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCPPVGLSPMHFPCHMT-IEPSTFLA 121
G + SL + N + L D F L ++ L L N ++T I
Sbjct: 179 GALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHN-------------NLTEITKGWLYG 225
Query: 122 VPTLEELNLSYNNIMTVPA----LPKSLISLSLSHTNILMLDSASLAGLHALRFLFMDGN 177
+ L+EL+LS N I + + L L L+ ++ LD +S GL L L + N
Sbjct: 226 LLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNN 285
Query: 178 -------CYYK------------NPCRQALEVAPGALLGLGNLTHLSLKYNNLTVVPRNL 218
C ++ N +E GA GL L L L+ N + + +
Sbjct: 286 RVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKA 345
Query: 219 PS---SLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGNCRRCD 259
+ +LE+L LS N I+ L + + L+ L + + CD
Sbjct: 346 FTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCD 389
Score = 36.2 bits (82), Expect = 0.16
Identities = 18/58 (31%), Positives = 35/58 (60%), Gaps = 2/58 (3%)
Query: 703 LRRLDVSCNSISFVAPGFFSKAKELRELNLSANALKTVDHSWFGPLASALQILDVSAN 760
+ R D+S N +SF+ S + LRE+ L+ N L+T+ + GP+++ + +L ++ N
Sbjct: 16 ISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPN--LGPVSANITLLSLAGN 71
>gi|45505137 podocan [Homo sapiens]
Length = 661
Score = 84.7 bits (208), Expect = 4e-16
Identities = 154/584 (26%), Positives = 224/584 (38%), Gaps = 120/584 (20%)
Query: 210 NLTVVPRNLPSSLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGNCRRCDHAPNPCMECP 269
+L P +LP +L L N++ K+ PE+L+ L L L++ N P
Sbjct: 134 DLREFPGDLPEHTNHLSLQNNQLEKIYPEELSRLHRLETLNLQNNRLTSRGLPEKA---- 189
Query: 270 RHFPQLHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNLRV-LDLSENFLYKCITKTK 328
F HL+ L L L ++ L+ R L N + +D + N+L K
Sbjct: 190 ----------FEHLTNLNYLYLANNKLTLAP----RFLPNALISVDFAANYLTK------ 229
Query: 329 AFQGLTQLRKLNLSFNYQKRVSFAHLSLAPS-FGSLVALKELDMHGIFFRSLDETTLRPL 387
GLT +K NL Y A L + F ++ L + F R + P
Sbjct: 230 -IYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFNGSSNVEVLILSSNFLRHV------PK 282
Query: 388 ARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYVDLSDNRISGASELTATMGEADGGEKVW 447
P L L L+ N + + G F LR + L +N ++ E E W
Sbjct: 283 HLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTD---------EGLDNETFW 333
Query: 448 LQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLSRNNLVTVQPEMFAQLSHLQCLRLSHNC 507
S+L + LDLS NNL V + L L L N
Sbjct: 334 ---------------------KLSSLEY-LDLSSNNLSRVPAGLPRSLV---LLHLEKNA 368
Query: 508 ISQAVNGSQFLPLTGLQVLDLSHNKL--DLYHEHSFTELPRLEALDLSYNSQPFGMQGVG 565
I ++V+ + P+ L+ L L N+L H +F L RL + L N+ G+
Sbjct: 369 I-RSVDANVLTPIRSLEYLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERVPSGLP 427
Query: 566 HNFSFVAHLRTLRHLSLAHNNIHSQVSQQLCSTS-LRALDFSGNALGHMWAEGDLYLHFF 624
R +R L + HN I + +T L L+ S N + D F
Sbjct: 428 ---------RRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQVHRDA----F 474
Query: 625 QGLSGLIWLDLSQNRLHTLLPQTLRNLPKSLQVLRLRDNYLAFFKWWSL----------- 673
+ L L LDLS NRLHTL P LP+++ VL+++ N LA +L
Sbjct: 475 RKLRLLRSLDLSGNRLHTLPP----GLPRNVHVLKVKRNELAALARGALVGMAQLRELYL 530
Query: 674 ---------------HFLPKLEVLDLAGNQLKALTNGSLPAGTRLRRLDVSCNSISFVAP 718
L L++LD+AGNQL + G LP L L + N IS V
Sbjct: 531 TSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIPEG-LPES--LEYLYLQNNKISAVPA 587
Query: 719 GFFSKAKELRELNLSAN--ALKTVDHSWFGPLASALQILDVSAN 760
F L+ + L N A+ +V S F L LQ+LD+ N
Sbjct: 588 NAFDSTPNLKGIFLRFNKLAVGSVVDSAFRRL-KHLQVLDIEGN 630
Score = 73.9 bits (180), Expect = 7e-13
Identities = 137/568 (24%), Positives = 218/568 (38%), Gaps = 87/568 (15%)
Query: 35 CELQPHGLVNCNWLFLKSVPHFSMAAPRGNVTSLSLSSNRIHHLHDSDFAHLPSLRHLNL 94
C G+V+C + L+ P P + LSL +N++ ++ + + L L LNL
Sbjct: 120 CACSQEGVVDCGGIDLREFPG---DLPE-HTNHLSLQNNQLEKIYPEELSRLHRLETLNL 175
Query: 95 KWNCPPVGLSPMHFPCHMTIEPSTFLAVPTLEELNLSYNNIMTVPA-LPKSLISLSLSHT 153
+ N L+ P F + L L L+ N + P LP +LIS+ +
Sbjct: 176 QNN----RLTSRGLP------EKAFEHLTNLNYLYLANNKLTLAPRFLPNALISVDFAAN 225
Query: 154 NILMLDSASLAGLHALRFLFMDGNCYYKNPCRQALEVAPGALL-GLGNLTHLSLKYNNLT 212
+ + + LR +++ N + A P + G N+ L L N L
Sbjct: 226 YLTKIYGLTFGQKPNLRSVYLHNN-------KLADAGLPDNMFNGSSNVEVLILSSNFLR 278
Query: 213 VVPRNLPSSLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGNCRRCDHAPNPCMECPRHF 272
VP++LP +L L L N++ K+ P + L++LR L + N + N
Sbjct: 279 HVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDN--------- 329
Query: 273 PQLHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGL---------------------GNLR 311
+TF LS LE L L ++LS + A R L +L
Sbjct: 330 -----ETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDANVLTPIRSLE 384
Query: 312 VLDLSENFLYKCITKTKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSFGSLVALKELDM 371
L L N L + AFQGL +L ++L N +RV S P + + +
Sbjct: 385 YLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERVP----SGLPRRVRTLMILHNQI 440
Query: 372 HGIFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQL--GIFRAFPGLRYVDLSDNRISG 429
GI A L+ L L N I Q+ FR LR +DLS NR+
Sbjct: 441 TGI--------GREDFATTYFLEELNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLH- 491
Query: 430 ASELTATMGEADGGEKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLSRNNLVTVQP 489
T G + ++ +LA + L +R + P
Sbjct: 492 ----TLPPGLPRNVHVLKVKRNELAAL-----ARGALVGMAQLRELYLTSNRLRSRALGP 542
Query: 490 EMFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEA 549
+ L+HLQ L ++ N +++ G LP L+ L L +NK+ ++F P L+
Sbjct: 543 RAWVDLAHLQLLDIAGNQLTEIPEG---LP-ESLEYLYLQNNKISAVPANAFDSTPNLKG 598
Query: 550 LDLSYNSQPFGMQGVGHNFSFVAHLRTL 577
+ L +N G V F + HL+ L
Sbjct: 599 IFLRFNKLAVG-SVVDSAFRRLKHLQVL 625
Score = 58.5 bits (140), Expect = 3e-08
Identities = 71/259 (27%), Positives = 114/259 (44%), Gaps = 36/259 (13%)
Query: 526 LDLSHNKLDLYHEHSFTELPRLEALDLSYNSQPFGMQGVGHNFSFVAHLRTLRHLSLAHN 585
L L +N+L+ + + L RLE L+L N + G HL L +L LA+N
Sbjct: 149 LSLQNNQLEKIYPEELSRLHRLETLNLQNNR----LTSRGLPEKAFEHLTNLNYLYLANN 204
Query: 586 NIHSQVSQQLCSTSLRALDFSGNALGHMWA--------EGDLYLH------------FFQ 625
+ ++ + +L ++DF+ N L ++ +YLH F
Sbjct: 205 KL--TLAPRFLPNALISVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFN 262
Query: 626 GLSGLIWLDLSQNRLHTLLPQTLRNLPKSLQVLRLRDNYLAFFKWWSLHFLPKLEVLDLA 685
G S + L LS N L ++LP +L L L++N L + L L L L
Sbjct: 263 GSSNVEVLILSSN----FLRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQ 318
Query: 686 GNQL--KALTNGSLPAGTRLRRLDVSCNSISFVAPGFFSKAKELRELNLSANALKTVDHS 743
N L + L N + + L LD+S N++S V G + L L+L NA+++VD +
Sbjct: 319 NNYLTDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGL---PRSLVLLHLEKNAIRSVDAN 375
Query: 744 WFGPLASALQILDVSANPL 762
P+ S L+ L + +N L
Sbjct: 376 VLTPIRS-LEYLLLHSNQL 393
Score = 54.3 bits (129), Expect = 6e-07
Identities = 89/381 (23%), Positives = 139/381 (36%), Gaps = 107/381 (28%)
Query: 49 FLKSVPHFSMAAPRGNVTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCPPVGLSPMHF 108
FL+ VP A + L L +N++ + F+ L SLR L L+ N +
Sbjct: 276 FLRHVPKHLPPA----LYKLHLKNNKLEKIPPGAFSELSSLRELYLQNN----------Y 321
Query: 109 PCHMTIEPSTFLAVPTLEELNLSYNNIMTVPA-LPKSLISLSLSHTNILMLDSASLA--- 164
++ TF + +LE L+LS NN+ VPA LP+SL+ L L I +D+ L
Sbjct: 322 LTDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDANVLTPIR 381
Query: 165 ---------------GLHALRF--------LFMDGNCYYKNPCR-----QALEVAPGALL 196
G+H L F + + N + P + L + +
Sbjct: 382 SLEYLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMILHNQIT 441
Query: 197 GLGN--------LTHLSLKYNNLT--------------------------VVPRNLPSSL 222
G+G L L+L YN +T +P LP ++
Sbjct: 442 GIGREDFATTYFLEELNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRNV 501
Query: 223 EYLLLSYNRIVKLAPEDLANLTALRVLDVGGNCRRC-----------------DHAPNPC 265
L + N + LA L + LR L + N R D A N
Sbjct: 502 HVLKVKRNELAALARGALVGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLLDIAGNQL 561
Query: 266 MECPRHFPQLHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSENFLYKCIT 325
E P P+ LE L L+++ +S + A+ F NL+ + L N L
Sbjct: 562 TEIPEGLPE----------SLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLAVGSV 611
Query: 326 KTKAFQGLTQLRKLNLSFNYQ 346
AF+ L L+ L++ N +
Sbjct: 612 VDSAFRRLKHLQVLDIEGNLE 632
>gi|7662320 leucine-rich repeats and immunoglobulin-like domains 2
[Homo sapiens]
Length = 1065
Score = 84.3 bits (207), Expect = 5e-16
Identities = 109/416 (26%), Positives = 181/416 (43%), Gaps = 69/416 (16%)
Query: 335 QLRKLNLSFNYQK----RVSFAHLSLAPSFGSLVALKELDMHGIFFRSLDETTLRPLARL 390
+L N+S Q ++++ L+ P FG + + + + + E + L
Sbjct: 86 RLSNWNISLESQTLQEVKMNYNELTEIPYFGEPTS--NITLLSLVHNIIPEINAQALQFY 143
Query: 391 PMLQTLRLQMNFINQAQLGIFRAFPGLRYVDLSDNRISGASELTATMGEADGGEKVWLQP 450
P L++L L N I++ + F L+Y++LS+NRI+ T G D
Sbjct: 144 PALESLDLSSNIISEIKTSSFPRMQ-LKYLNLSNNRIT-----TLEAGCFD--------- 188
Query: 451 GDLAPAPVDTPSSEDFRPNCSTLNFTLDLSRNNLVTVQPEMFAQLSHLQCLRLSHNCISQ 510
N S+ + L+RN + + P++F +L HLQ L L N I +
Sbjct: 189 ------------------NLSSSLLVVKLNRNRMSMIPPKIF-KLPHLQFLELKRNRI-K 228
Query: 511 AVNGSQFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEALDLSYNSQPFGMQGVGHNFSF 570
V G F L L+ L + N + + +F L +E L+L +N+ +G +
Sbjct: 229 IVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKG------W 282
Query: 571 VAHLRTLRHLSLAHNNIH--SQVSQQLCSTSLRALDFSGNALGHMWAEGDLYLHFFQGLS 628
+ LR L+ L ++ N I S + + C L LD S N L + F GLS
Sbjct: 283 LYGLRMLQQLYVSQNAIERISPDAWEFCQR-LSELDLSYNQLTRLDESA------FVGLS 335
Query: 629 GLIWLDLSQNRLHTLLPQTLRNLPKSLQVLRLRDNYLAFFKWWSLHF-------LPKLEV 681
L L+L NR+ + R L +LQ L LR+N ++ W++ L L
Sbjct: 336 LLERLNLGDNRVTHIADGVFRFL-SNLQTLDLRNNEIS----WAIEDASEAFAGLTSLTK 390
Query: 682 LDLAGNQLKALTNGSLPAGTRLRRLDVSCNSISFVAPGFFSKAKELRELNLSANAL 737
L L GNQ+K++T + L LD++ N+I + FS+ L+EL L+ ++L
Sbjct: 391 LILQGNQIKSITKKAFIGLESLEHLDLNNNAIMSIQENAFSQT-HLKELILNTSSL 445
Score = 82.4 bits (202), Expect = 2e-15
Identities = 102/371 (27%), Positives = 152/371 (40%), Gaps = 77/371 (20%)
Query: 43 VNCNWLFLKSVPHFSMAAPRGNVTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCPPVG 102
V N+ L +P+F P N+T LSL N I ++ P+L L+L N
Sbjct: 102 VKMNYNELTEIPYFG--EPTSNITLLSLVHNIIPEINAQALQFYPALESLDLSSNIIS-- 157
Query: 103 LSPMHFPCHMTIEPSTFLAVPTLEELNLSYNNIMTVPA-----LPKSLISLSLSHTNILM 157
I+ S+F + L+ LNLS N I T+ A L SL+ + L+ + M
Sbjct: 158 ----------EIKTSSFPRMQ-LKYLNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRMSM 206
Query: 158 L-----------------------DSASLAGLHALRFLFMDGNCYYKNPCRQALEVAPGA 194
+ + + GL +LR L M N K + GA
Sbjct: 207 IPPKIFKLPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISK--------LKDGA 258
Query: 195 LLGLGNLTHLSLKYNNLTVVPRNLPSSL---EYLLLSYNRIVKLAPEDLANLTALRVLDV 251
GL N+ L L++NNLT V + L + L +S N I +++P+ L LD+
Sbjct: 259 FFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDL 318
Query: 252 GGNCRRCDHAPNPCMECPRHFPQLHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNLR 311
N +L F LS LE L L D+ ++ + FR L NL+
Sbjct: 319 SYN----------------QLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQ 362
Query: 312 VLDLSENFLYKCI-TKTKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSFGSLVALKELD 370
LDL N + I ++AF GLT L KL L N K ++ +F L +L+ LD
Sbjct: 363 TLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSIT------KKAFIGLESLEHLD 416
Query: 371 MHGIFFRSLDE 381
++ S+ E
Sbjct: 417 LNNNAIMSIQE 427
Score = 67.0 bits (162), Expect = 9e-11
Identities = 105/396 (26%), Positives = 171/396 (43%), Gaps = 67/396 (16%)
Query: 124 TLEELNLSYNNIMTVPAL--PKSLISL-SLSHTNILMLDSASLAGLHALRFLFMDGNCYY 180
TL+E+ ++YN + +P P S I+L SL H I +++ +L AL L + N
Sbjct: 98 TLQEVKMNYNELTEIPYFGEPTSNITLLSLVHNIIPEINAQALQFYPALESLDLSSNIIS 157
Query: 181 KNPCRQALEVAPGALLGLGNLTHLSLKYNNLTVVPR----NLPSSLEYLLLSYNRIVKLA 236
E+ + + L +L+L N +T + NL SSL + L+ NR+ +
Sbjct: 158 --------EIKTSSFPRM-QLKYLNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRMSMIP 208
Query: 237 PEDLANLTALRVLDVGGNCRRCDHAPNPCMECPRHFPQLHPDTFSHLSRLEGLVLKDSSL 296
P+ + L L+ L++ N + TF L L L ++ + +
Sbjct: 209 PK-IFKLPHLQFLELKRN----------------RIKIVEGLTFQGLDSLRSLKMQRNGI 251
Query: 297 SWLNASWFRGLGNLRVLDLSENFLYKCITKTKAFQGLTQLRKLNLSFNYQKRVSFAHLSL 356
S L F GL N+ L+L N L + + K + GL L++L +S N +R+S
Sbjct: 252 SKLKDGAFFGLNNMEELELEHNNLTR-VNKGWLY-GLRMLQQLYVSQNAIERIS------ 303
Query: 357 APSFGSLVALKELDMHGIFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPG 416
++ L ELD+ LDE+ L +L+ L L N + G+FR
Sbjct: 304 PDAWEFCQRLSELDLSYNQLTRLDESAF---VGLSLLERLNLGDNRVTHIADGVFRFLSN 360
Query: 417 LRYVDLSDNRISGASELTATMGEADGG----EKVWLQPGDL----APAPVDTPSSEDFRP 468
L+ +DL +N IS A E EA G K+ LQ + A + S E
Sbjct: 361 LQTLDLRNNEISWAIE---DASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEH--- 414
Query: 469 NCSTLNFTLDLSRNNLVTVQPEMFAQLSHLQCLRLS 504
LDL+ N ++++Q F+Q +HL+ L L+
Sbjct: 415 --------LDLNNNAIMSIQENAFSQ-THLKELILN 441
Score = 63.2 bits (152), Expect = 1e-09
Identities = 79/301 (26%), Positives = 144/301 (47%), Gaps = 37/301 (12%)
Query: 477 LDLSRNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLY 536
LD S N L + +Q LQ +++++N +++ + P + + +L L HN +
Sbjct: 80 LDFSHNRLSNWNISLESQT--LQEVKMNYNELTEIPYFGE--PTSNITLLSLVHNIIPEI 135
Query: 537 HEHSFTELPRLEALDLSYNSQPFGMQGVGHNFSFVAHLRT-------LRHLSLAHNNIHS 589
+ + P LE+LDLS N ++ ++T L++L+L++N I +
Sbjct: 136 NAQALQFYPALESLDLSSN--------------IISEIKTSSFPRMQLKYLNLSNNRITT 181
Query: 590 QVSQQL--CSTSLRALDFSGNALGHMWAEGDLYLHFFQGLSGLIWLDLSQNRLHTLLPQT 647
+ S+SL + + N + + + F+ L L +L+L +NR+ + T
Sbjct: 182 LEAGCFDNLSSSLLVVKLNRNRMSMIPPK------IFK-LPHLQFLELKRNRIKIVEGLT 234
Query: 648 LRNLPKSLQVLRLRDNYLAFFKWWSLHFLPKLEVLDLAGNQLKALTNGSLPAGTRLRRLD 707
+ L SL+ L+++ N ++ K + L +E L+L N L + G L L++L
Sbjct: 235 FQGLD-SLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLY 293
Query: 708 VSCNSISFVAPGFFSKAKELRELNLSANALKTVDHSWFGPLASALQILDVSANPL-HCAC 766
VS N+I ++P + + L EL+LS N L +D S F L S L+ L++ N + H A
Sbjct: 294 VSQNAIERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGL-SLLERLNLGDNRVTHIAD 352
Query: 767 G 767
G
Sbjct: 353 G 353
Score = 35.4 bits (80), Expect = 0.28
Identities = 43/176 (24%), Positives = 72/176 (40%), Gaps = 31/176 (17%)
Query: 68 LSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCPPVGLSPMHFPCHMT-IEPSTFLAVPTLE 126
L +S N I + + L L+L +N +T ++ S F+ + LE
Sbjct: 292 LYVSQNAIERISPDAWEFCQRLSELDLSYN-------------QLTRLDESAFVGLSLLE 338
Query: 127 ELNLSYNNIMTVP----ALPKSLISLSLSHTNILML---DSASLAGLHALRFLFMDGNCY 179
LNL N + + +L +L L + I S + AGL +L L + GN
Sbjct: 339 RLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGN-- 396
Query: 180 YKNPCRQALEVAPGALLGLGNLTHLSLKYNNLTVVPRNLPSS--LEYLLLSYNRIV 233
Q + A +GL +L HL L N + + N S L+ L+L+ + ++
Sbjct: 397 ------QIKSITKKAFIGLESLEHLDLNNNAIMSIQENAFSQTHLKELILNTSSLL 446
>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
[Homo sapiens]
Length = 1093
Score = 83.6 bits (205), Expect = 9e-16
Identities = 117/429 (27%), Positives = 169/429 (39%), Gaps = 86/429 (20%)
Query: 114 IEPSTFLAVPTLEELNLSYNNIMTVPALPKS---LISLSLSHTNILMLDSASLAGLHALR 170
I+P+ F +P L+E+ L+ N + VP+L + ++SL L H I ++ + L +L
Sbjct: 83 IDPAGFEDLPNLQEVYLNNNELTAVPSLGAASSHVVSLFLQHNKIRSVEGSQLKAYLSLE 142
Query: 171 FLFMDGN--------CYYKNPCRQALEVAPGAL--LGLGNLTHLSLKYNNLTVVPRNLPS 220
L + N C+ P + L +A + L LG LS
Sbjct: 143 VLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLS--------------R 188
Query: 221 SLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGNCRRCDHAPNPCMECPRHFPQLHPDTF 280
SL L LS NRI +L P L L LD+ N R + TF
Sbjct: 189 SLLTLRLSKNRITQL-PVRAFKLPRLTQLDLNRNRIRL----------------IEGLTF 231
Query: 281 SHLSRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSENFLYKCITKTKAFQGLTQLRKLN 340
L+ LE L L+ +++S L F GL + VL L N L + + + GLT L +L+
Sbjct: 232 QGLNSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNSLVE--VNSGSLYGLTALHQLH 289
Query: 341 LSFNYQKRVSFAHLSLAPSFGSLVALKELDMHGIFFRSLDETTLRPLARLPMLQTLRLQM 400
LS N R+ S LV + F +L LA L L LRL
Sbjct: 290 LSNNSIARIHRKGWSFCQKLHELV---------LSFNNLTRLDEESLAELSSLSVLRLSH 340
Query: 401 NFINQAQLGIFRAFPGLRYVDLSDNRISGASELTATMGEADGGEKVWLQPGDLAPAPVDT 460
N I+ G F+ LR +DL N ISG E T G G +D+
Sbjct: 341 NSISHIAEGAFKGLRSLRVLDLDHNEISGTIE--DTSGAFSG---------------LDS 383
Query: 461 PSSEDFRPNCSTLNFTLDLSRNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSQFLPL 520
S L L N + +V F+ L L+ L L N I ++V F+ +
Sbjct: 384 LSK-------------LTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAI-RSVQFDAFVKM 429
Query: 521 TGLQVLDLS 529
L+ L +S
Sbjct: 430 KNLKELHIS 438
Score = 82.8 bits (203), Expect = 2e-15
Identities = 133/509 (26%), Positives = 203/509 (39%), Gaps = 102/509 (20%)
Query: 302 SWFRGLGNLRVLDLSENFLYKCITKTKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSFG 361
SW R L NL LSE F+ L L+++ L+ N L+ PS G
Sbjct: 68 SWTRSL-NLSYNKLSE-------IDPAGFEDLPNLQEVYLNNN--------ELTAVPSLG 111
Query: 362 SLVA-LKELDMHGIFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYV 420
+ + + L + RS++ + L+ L +L L +N I + + F P ++ +
Sbjct: 112 AASSHVVSLFLQHNKIRSVEGSQLKAYLSLEVLD---LSLNNITEVRNTCFPHGPPIKEL 168
Query: 421 DLSDNRISGASELTATMGEADGGEKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLS 480
+L+ NRI T +G DG + L TL LS
Sbjct: 169 NLAGNRIG-----TLELGAFDGLSRSLL---------------------------TLRLS 196
Query: 481 RNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHS 540
+N + + F +L L L L+ N I + + G F L L+VL L N + + +
Sbjct: 197 KNRITQLPVRAF-KLPRLTQLDLNRNRI-RLIEGLTFQGLNSLEVLKLQRNNISKLTDGA 254
Query: 541 FTELPRLEALDLSYNSQPFGMQGVGHNFSFVAHLRTLRHLSLAHNNIHSQVSQQLCSTSL 600
F L ++ L L YNS L N S T+L
Sbjct: 255 FWGLSKMHVLHLEYNS-------------------------LVEVNSGSLYGL----TAL 285
Query: 601 RALDFSGNALGHMWAEGDLYLHFFQGLSGLIWLDLSQNRLHTLLPQTLRNLPKSLQVLRL 660
L S N++ + +G F Q L L+ LS N L L ++L L SL VLRL
Sbjct: 286 HQLHLSNNSIARIHRKG---WSFCQKLHELV---LSFNNLTRLDEESLAEL-SSLSVLRL 338
Query: 661 RDNYLAFFKWWSLHFLPKLEVLDLAGNQLKAL---TNGSLPAGTRLRRLDVSCNSISFVA 717
N ++ + L L VLDL N++ T+G+ L +L + N I VA
Sbjct: 339 SHNSISHIAEGAFKGLRSLRVLDLDHNEISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVA 398
Query: 718 PGFFSKAKELRELNLSANALKTVDHSWFGPLASALQILDVSANPLHCACGAAFMDFLL-- 775
FS + L LNL NA+++V F + + L+ L +S++ C C ++ L
Sbjct: 399 KRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKN-LKELHISSDSFLCDCQLKWLPPWLIG 457
Query: 776 -EVQAAVPGLPSRVKCGSPGQLQGLSIFA 803
+QA V C P L+G SIF+
Sbjct: 458 RMLQAFV-----TATCAHPESLKGQSIFS 481
Score = 77.0 bits (188), Expect = 8e-14
Identities = 93/332 (28%), Positives = 132/332 (39%), Gaps = 74/332 (22%)
Query: 68 LSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCPPV-------GLSPMHFPCHMTIEPSTFL 120
L LS N I + ++ F H P ++ LNL N GLS ++ T L
Sbjct: 144 LDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLLTLRLSKNRITQL 203
Query: 121 AV-----PTLEELNLSYNNIMTVPALP----KSLISLSLSHTNILMLDSASLAGLHALRF 171
V P L +L+L+ N I + L SL L L NI L + GL +
Sbjct: 204 PVRAFKLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKMHV 263
Query: 172 LFMDGNCYYKNPCRQALEVAPGALLGLGNLTHLSLKYNNLTVVPR---NLPSSLEYLLLS 228
L ++ N +EV G+L GL L L L N++ + R + L L+LS
Sbjct: 264 LHLEYN--------SLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLHELVLS 315
Query: 229 YNRIVKLAPEDLANLTALRVLDVGGNCRRCDHAPNPCMECPRHFPQLHPDTFSHLSRLEG 288
+N + +L E LA L++L VL + N
Sbjct: 316 FNNLTRLDEESLAELSSLSVLRLSHN---------------------------------- 341
Query: 289 LVLKDSSLSWLNASWFRGLGNLRVLDLSENFLYKCITKTK-AFQGLTQLRKLNLSFNYQK 347
S+S + F+GL +LRVLDL N + I T AF GL L KL L N K
Sbjct: 342 ------SISHIAEGAFKGLRSLRVLDLDHNEISGTIEDTSGAFSGLDSLSKLTLFGNKIK 395
Query: 348 RVSFAHLSLAPSFGSLVALKELDMHGIFFRSL 379
V+ +F L L+ L++ G RS+
Sbjct: 396 SVA------KRAFSGLEGLEHLNLGGNAIRSV 421
>gi|156139147 leucine rich repeat transmembrane neuronal 4 isoform b
[Homo sapiens]
Length = 518
Score = 83.6 bits (205), Expect = 9e-16
Identities = 89/334 (26%), Positives = 136/334 (40%), Gaps = 40/334 (11%)
Query: 465 DFRPNCSTLNFTLDLSRNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQ 524
D N S + L L N++ ++ FA L+ L L L HN IS +V+ F + L+
Sbjct: 54 DIPENISGGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYIS-SVDEDAFQGIRRLK 112
Query: 525 VLDLSHNKLDLYHEHSFTELPRLEALDLSYNSQPFGMQGVGHNFSFVAHLRTLRHLSLAH 584
L LS NK+ H +F +P L LDLSYN L+TL+ S
Sbjct: 113 ELILSSNKITYLHNKTFHPVPNLRNLDLSYNK-----------------LQTLQ--SEQF 153
Query: 585 NNIHSQVSQQLCSTSLRALDFSGNALGHMWAEGDLYLHFFQGLSGLIWLDLSQNRLHTLL 644
+ + L S SL+ + + FQ L +LDL NRL +L
Sbjct: 154 KGLRKLIILHLRSNSLKTVP----------------IRVFQDCRNLDFLDLGYNRLRSLS 197
Query: 645 PQTLRNLPKSLQVLRLRDNYLAFFKWWSLHFLPKLEVLDLAGNQLKALTNGSLPAGTRLR 704
L K L+ L L N + + L L + L N++++++ G + L
Sbjct: 198 RNAFAGLLK-LKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSISQGLTWTWSSLH 256
Query: 705 RLDVSCNSISFVAPGFFSKAKELRELNLSANALKTVDHSWFGPLASALQILDVSANPLHC 764
LD+S N I + PG F L++LNL +N L + S + I +S N C
Sbjct: 257 NLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWISLISI-TLSGNMWEC 315
Query: 765 ACGAAFMDFLLEVQAAVPGLPSRVKCGSPGQLQG 798
+ + + L+ S + C P +QG
Sbjct: 316 SRSICPLFYWLKNFKG--NKESTMICAGPKHIQG 347
Score = 58.9 bits (141), Expect = 2e-08
Identities = 63/234 (26%), Positives = 96/234 (41%), Gaps = 39/234 (16%)
Query: 214 VPRNLPSSLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGNCRRCDHAPNPCMECPRHFP 273
+P N+ + L L +N I KL A L L L + N +
Sbjct: 55 IPENISGGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHN----------------YIS 98
Query: 274 QLHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSENFLYKCITKTKAFQGL 333
+ D F + RL+ L+L + +++L+ F + NLR LDLS N L +++ F+GL
Sbjct: 99 SVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQ--TLQSEQFKGL 156
Query: 334 TQLRKLNLSFNYQKRV-----------SFAHLSL-------APSFGSLVALKELDMHGIF 375
+L L+L N K V F L +F L+ LKEL +
Sbjct: 157 RKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQ 216
Query: 376 FRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYVDLSDNRISG 429
F ++ RL L+++ LQ N I G+ + L +DLS N I G
Sbjct: 217 FSKIN---FAHFPRLFNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQG 267
Score = 58.2 bits (139), Expect = 4e-08
Identities = 64/241 (26%), Positives = 102/241 (42%), Gaps = 30/241 (12%)
Query: 197 GLGNLTHLSLKYNNLTVVPRNLPSS---LEYLLLSYNRIVKLAPEDLANLTALRVLDVGG 253
GL L L L +N ++ V + L+ L+LS N+I L + + LR LD+
Sbjct: 83 GLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSY 142
Query: 254 NCRRCDHAPNPCMECPRHFPQLHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNLRVL 313
N L + F L +L L L+ +SL + F+ NL L
Sbjct: 143 N----------------KLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFL 186
Query: 314 DLSENFLYKCITKTKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSFGSLVALKELDMHG 373
DL N L AF GL +L++L+L N +++FAH F L L+ + +
Sbjct: 187 DLGYNRLRSL--SRNAFAGLLKLKELHLEHNQFSKINFAH------FPRLFNLRSIYLQW 238
Query: 374 IFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYVDLSDNRISGASEL 433
RS+ + + L L L N I + G F+ P L+ ++L N+++ S+
Sbjct: 239 NRIRSISQGLTWTWSSL---HNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQE 295
Query: 434 T 434
T
Sbjct: 296 T 296
Score = 57.8 bits (138), Expect = 5e-08
Identities = 77/257 (29%), Positives = 109/257 (42%), Gaps = 25/257 (9%)
Query: 394 QTLRLQMNFINQAQLGIFRAFPGLRYVDLSDNRISGASELTATMGEADGGEKVWLQPGDL 453
Q L L+ N I + + F L ++ L N IS E A G E + L
Sbjct: 64 QGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDE-DAFQGIRRLKELI------L 116
Query: 454 APAPVDTPSSEDFRPNCSTLNFTLDLSRNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVN 513
+ + ++ F P + N LDLS N L T+Q E F L L L L N + + V
Sbjct: 117 SSNKITYLHNKTFHPVPNLRN--LDLSYNKLQTLQSEQFKGLRKLIILHLRSNSL-KTVP 173
Query: 514 GSQFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEALDLSYNSQPFGMQGVGHNFSFVAH 573
F L LDL +N+L ++F L +L+ L L +N Q NF+
Sbjct: 174 IRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHN------QFSKINFAHFPR 227
Query: 574 LRTLRHLSLAHNNIHSQVSQQLCST--SLRALDFSGNALGHMWAEGDLYLHFFQGLSGLI 631
L LR + L N I S +SQ L T SL LD SGN + + F+ L L
Sbjct: 228 LFNLRSIYLQWNRIRS-ISQGLTWTWSSLHNLDLSGNDI------QGIEPGTFKCLPNLQ 280
Query: 632 WLDLSQNRLHTLLPQTL 648
L+L N+L + +T+
Sbjct: 281 KLNLDSNKLTNISQETV 297
Score = 53.1 bits (126), Expect = 1e-06
Identities = 62/226 (27%), Positives = 99/226 (43%), Gaps = 33/226 (14%)
Query: 41 GLVNCNWLFL-----KSVPHFSMAAPRGNVTSLSLSSNRIHHLHDSDFAHLPSLRHLNLK 95
GL WL+L SV + R + L LSSN+I +LH+ F +P+LR+L+L
Sbjct: 83 GLNQLIWLYLDHNYISSVDEDAFQGIR-RLKELILSSNKITYLHNKTFHPVPNLRNLDLS 141
Query: 96 WNCPPVGLSPMHFPCHMTIEPSTFLAVPTLEELNLSYNNIMTVPALP----KSLISLSLS 151
+N T++ F + L L+L N++ TVP ++L L L
Sbjct: 142 YN------------KLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLG 189
Query: 152 HTNILMLDSASLAGLHALRFLFMDGNCYYKNPCRQALEVAPGALLGLGNLTHLSLKYNNL 211
+ + L + AGL L+ L ++ N + K + L NL + L++N +
Sbjct: 190 YNRLRSLSRNAFAGLLKLKELHLEHNQFSK--------INFAHFPRLFNLRSIYLQWNRI 241
Query: 212 TVVPRNLP---SSLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGN 254
+ + L SSL L LS N I + P L L+ L++ N
Sbjct: 242 RSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSN 287
Score = 34.7 bits (78), Expect = 0.48
Identities = 30/100 (30%), Positives = 45/100 (45%), Gaps = 16/100 (16%)
Query: 68 LSLSSNRIHHLHDSDFAHLPSLRHLNLKWN---CPPVGLSPMHFPCH---------MTIE 115
L L N+ ++ + F L +LR + L+WN GL+ H IE
Sbjct: 210 LHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIE 269
Query: 116 PSTFLAVPTLEELNLSYNNIMTVPALPK----SLISLSLS 151
P TF +P L++LNL N + + SLIS++LS
Sbjct: 270 PGTFKCLPNLQKLNLDSNKLTNISQETVNAWISLISITLS 309
>gi|197927168 leucine rich repeat transmembrane neuronal 4 isoform a
[Homo sapiens]
Length = 590
Score = 83.6 bits (205), Expect = 9e-16
Identities = 89/334 (26%), Positives = 136/334 (40%), Gaps = 40/334 (11%)
Query: 465 DFRPNCSTLNFTLDLSRNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQ 524
D N S + L L N++ ++ FA L+ L L L HN IS +V+ F + L+
Sbjct: 54 DIPENISGGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYIS-SVDEDAFQGIRRLK 112
Query: 525 VLDLSHNKLDLYHEHSFTELPRLEALDLSYNSQPFGMQGVGHNFSFVAHLRTLRHLSLAH 584
L LS NK+ H +F +P L LDLSYN L+TL+ S
Sbjct: 113 ELILSSNKITYLHNKTFHPVPNLRNLDLSYNK-----------------LQTLQ--SEQF 153
Query: 585 NNIHSQVSQQLCSTSLRALDFSGNALGHMWAEGDLYLHFFQGLSGLIWLDLSQNRLHTLL 644
+ + L S SL+ + + FQ L +LDL NRL +L
Sbjct: 154 KGLRKLIILHLRSNSLKTVP----------------IRVFQDCRNLDFLDLGYNRLRSLS 197
Query: 645 PQTLRNLPKSLQVLRLRDNYLAFFKWWSLHFLPKLEVLDLAGNQLKALTNGSLPAGTRLR 704
L K L+ L L N + + L L + L N++++++ G + L
Sbjct: 198 RNAFAGLLK-LKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSISQGLTWTWSSLH 256
Query: 705 RLDVSCNSISFVAPGFFSKAKELRELNLSANALKTVDHSWFGPLASALQILDVSANPLHC 764
LD+S N I + PG F L++LNL +N L + S + I +S N C
Sbjct: 257 NLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWISLISI-TLSGNMWEC 315
Query: 765 ACGAAFMDFLLEVQAAVPGLPSRVKCGSPGQLQG 798
+ + + L+ S + C P +QG
Sbjct: 316 SRSICPLFYWLKNFKG--NKESTMICAGPKHIQG 347
Score = 58.9 bits (141), Expect = 2e-08
Identities = 63/234 (26%), Positives = 96/234 (41%), Gaps = 39/234 (16%)
Query: 214 VPRNLPSSLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGNCRRCDHAPNPCMECPRHFP 273
+P N+ + L L +N I KL A L L L + N +
Sbjct: 55 IPENISGGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHN----------------YIS 98
Query: 274 QLHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSENFLYKCITKTKAFQGL 333
+ D F + RL+ L+L + +++L+ F + NLR LDLS N L +++ F+GL
Sbjct: 99 SVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQ--TLQSEQFKGL 156
Query: 334 TQLRKLNLSFNYQKRV-----------SFAHLSL-------APSFGSLVALKELDMHGIF 375
+L L+L N K V F L +F L+ LKEL +
Sbjct: 157 RKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQ 216
Query: 376 FRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYVDLSDNRISG 429
F ++ RL L+++ LQ N I G+ + L +DLS N I G
Sbjct: 217 FSKIN---FAHFPRLFNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQG 267
Score = 58.2 bits (139), Expect = 4e-08
Identities = 64/241 (26%), Positives = 102/241 (42%), Gaps = 30/241 (12%)
Query: 197 GLGNLTHLSLKYNNLTVVPRNLPSS---LEYLLLSYNRIVKLAPEDLANLTALRVLDVGG 253
GL L L L +N ++ V + L+ L+LS N+I L + + LR LD+
Sbjct: 83 GLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSY 142
Query: 254 NCRRCDHAPNPCMECPRHFPQLHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNLRVL 313
N L + F L +L L L+ +SL + F+ NL L
Sbjct: 143 N----------------KLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFL 186
Query: 314 DLSENFLYKCITKTKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSFGSLVALKELDMHG 373
DL N L AF GL +L++L+L N +++FAH F L L+ + +
Sbjct: 187 DLGYNRLRSL--SRNAFAGLLKLKELHLEHNQFSKINFAH------FPRLFNLRSIYLQW 238
Query: 374 IFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYVDLSDNRISGASEL 433
RS+ + + L L L N I + G F+ P L+ ++L N+++ S+
Sbjct: 239 NRIRSISQGLTWTWSSL---HNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQE 295
Query: 434 T 434
T
Sbjct: 296 T 296
Score = 57.8 bits (138), Expect = 5e-08
Identities = 77/257 (29%), Positives = 109/257 (42%), Gaps = 25/257 (9%)
Query: 394 QTLRLQMNFINQAQLGIFRAFPGLRYVDLSDNRISGASELTATMGEADGGEKVWLQPGDL 453
Q L L+ N I + + F L ++ L N IS E A G E + L
Sbjct: 64 QGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDE-DAFQGIRRLKELI------L 116
Query: 454 APAPVDTPSSEDFRPNCSTLNFTLDLSRNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVN 513
+ + ++ F P + N LDLS N L T+Q E F L L L L N + + V
Sbjct: 117 SSNKITYLHNKTFHPVPNLRN--LDLSYNKLQTLQSEQFKGLRKLIILHLRSNSL-KTVP 173
Query: 514 GSQFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEALDLSYNSQPFGMQGVGHNFSFVAH 573
F L LDL +N+L ++F L +L+ L L +N Q NF+
Sbjct: 174 IRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHN------QFSKINFAHFPR 227
Query: 574 LRTLRHLSLAHNNIHSQVSQQLCST--SLRALDFSGNALGHMWAEGDLYLHFFQGLSGLI 631
L LR + L N I S +SQ L T SL LD SGN + + F+ L L
Sbjct: 228 LFNLRSIYLQWNRIRS-ISQGLTWTWSSLHNLDLSGNDI------QGIEPGTFKCLPNLQ 280
Query: 632 WLDLSQNRLHTLLPQTL 648
L+L N+L + +T+
Sbjct: 281 KLNLDSNKLTNISQETV 297
Score = 53.1 bits (126), Expect = 1e-06
Identities = 62/226 (27%), Positives = 99/226 (43%), Gaps = 33/226 (14%)
Query: 41 GLVNCNWLFL-----KSVPHFSMAAPRGNVTSLSLSSNRIHHLHDSDFAHLPSLRHLNLK 95
GL WL+L SV + R + L LSSN+I +LH+ F +P+LR+L+L
Sbjct: 83 GLNQLIWLYLDHNYISSVDEDAFQGIR-RLKELILSSNKITYLHNKTFHPVPNLRNLDLS 141
Query: 96 WNCPPVGLSPMHFPCHMTIEPSTFLAVPTLEELNLSYNNIMTVPALP----KSLISLSLS 151
+N T++ F + L L+L N++ TVP ++L L L
Sbjct: 142 YN------------KLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLG 189
Query: 152 HTNILMLDSASLAGLHALRFLFMDGNCYYKNPCRQALEVAPGALLGLGNLTHLSLKYNNL 211
+ + L + AGL L+ L ++ N + K + L NL + L++N +
Sbjct: 190 YNRLRSLSRNAFAGLLKLKELHLEHNQFSK--------INFAHFPRLFNLRSIYLQWNRI 241
Query: 212 TVVPRNLP---SSLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGN 254
+ + L SSL L LS N I + P L L+ L++ N
Sbjct: 242 RSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSN 287
Score = 34.7 bits (78), Expect = 0.48
Identities = 30/100 (30%), Positives = 45/100 (45%), Gaps = 16/100 (16%)
Query: 68 LSLSSNRIHHLHDSDFAHLPSLRHLNLKWN---CPPVGLSPMHFPCH---------MTIE 115
L L N+ ++ + F L +LR + L+WN GL+ H IE
Sbjct: 210 LHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIE 269
Query: 116 PSTFLAVPTLEELNLSYNNIMTVPALPK----SLISLSLS 151
P TF +P L++LNL N + + SLIS++LS
Sbjct: 270 PGTFKCLPNLQKLNLDSNKLTNISQETVNAWISLISITLS 309
>gi|62912474 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 3 [Homo sapiens]
Length = 828
Score = 83.6 bits (205), Expect = 9e-16
Identities = 86/295 (29%), Positives = 136/295 (46%), Gaps = 38/295 (12%)
Query: 478 DLSRNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLYH 537
DLS NNL +QP +F L L+ LRLS N +S + G F L L++L L +N+L
Sbjct: 29 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSH-IPGQAFSGLYSLKILMLQNNQLGGIP 87
Query: 538 EHSFTELPRLEALDLSYNS-QPFGMQGVGHNFSFVAHLRTLRHLSLAHNNIHSQVSQQLC 596
+ ELP L++LDL+YN Q F + + L L+ L +NNI + +
Sbjct: 88 AEALWELPSLQSLDLNYNKLQEFPVA--------IRTLGRLQELGFHNNNIKAIPEKAFM 139
Query: 597 STSL-RALDFSGNALGHMWAEGDLYLHFFQGLSGLIWLDLSQNRLHTLLPQTLRNLPK-- 653
L + + F N + F G S +L +LHTL ++ +
Sbjct: 140 GNPLLQTIHFYDNPIQ------------FVGRSAFQYLP----KLHTLSLNGAMDIQEFP 183
Query: 654 ------SLQVLRLRDNYLAFFKWWSLHFLPKLEVLDLAGNQLKALTNGSLPAGTRLRRLD 707
SL++L L + LP+L VL+L+ NQ++ L SL +L +
Sbjct: 184 DLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELP--SLHRCQKLEEIG 241
Query: 708 VSCNSISFVAPGFFSKAKELRELNLSANALKTVDHSWFGPLASALQILDVSANPL 762
+ N I + FS+ L+ L+LS NA++++ F L S ++ LD++ N L
Sbjct: 242 LQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVK-LDLTDNQL 295
Score = 55.1 bits (131), Expect = 3e-07
Identities = 96/363 (26%), Positives = 143/363 (39%), Gaps = 75/363 (20%)
Query: 227 LSYNRIVKLAPEDLANLTALRVLDVGGNCRRCDHAPNPCMECPRHFPQLHPDTFSHLSRL 286
LS N + +L P +L L L + GN H + FS L L
Sbjct: 30 LSMNNLTELQPGLFHHLRFLEELRLSGN----------------HLSHIPGQAFSGLYSL 73
Query: 287 EGLVLKDSSLSWLNASWFRGLGNLRVLDLSENFLY----------------------KCI 324
+ L+L+++ L + A L +L+ LDL+ N L K I
Sbjct: 74 KILMLQNNQLGGIPAEALWELPSLQSLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAI 133
Query: 325 TKTKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSFGSLVALKELDMHGIFFRSLDETTL 384
+ KAF G L+ ++ Y + F S +F L L L ++G ++D
Sbjct: 134 PE-KAFMGNPLLQTIHF---YDNPIQFVGRS---AFQYLPKLHTLSLNG----AMDIQEF 182
Query: 385 RPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYVDLSDNRISGASELTATMGEADGGE 444
L L+ L L I G+ + P LR ++LS N+I E ++ E
Sbjct: 183 PDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQI----EELPSLHRCQKLE 238
Query: 445 KVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLSRNNLVTVQPEMFAQLSHLQCLRLS 504
++ LQ + DT S S+L LDLS N + ++ PE F+ L L L L+
Sbjct: 239 EIGLQHNRIWEIGADTFSQ------LSSLQ-ALDLSWNAIRSIHPEAFSTLHSLVKLDLT 291
Query: 505 HNCISQAVNGSQFLPLTGLQVLDLSHNKLD----LYHEHSFTELPRLEALDLSYNSQ--P 558
N ++ LPL GL L H KL L S P+L L++ Y Q P
Sbjct: 292 DNQLTT-------LPLAGLG--GLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCCP 342
Query: 559 FGM 561
+GM
Sbjct: 343 YGM 345
Score = 50.1 bits (118), Expect = 1e-05
Identities = 80/300 (26%), Positives = 123/300 (41%), Gaps = 44/300 (14%)
Query: 68 LSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCPPVGLSPMHFPCHMTIEPSTFLAVPTLEE 127
L LS N + H+ F+ L SL+ L L+ N +G P +P+L+
Sbjct: 52 LRLSGNHLSHIPGQAFSGLYSLKILMLQNN--QLGGIPAE----------ALWELPSLQS 99
Query: 128 LNLSYNNIMTVPALPKSL---ISLSLSHTNILMLDSASLAGLHALRFLFMDGNCYYKNPC 184
L+L+YN + P ++L L + NI + + G L+ + +Y NP
Sbjct: 100 LDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIH-----FYDNPI 154
Query: 185 RQALEVAPGALLGLGNLTHLSLKYNNLTVVPRNLP-----SSLEYLLLSYNRIVKLAPED 239
+ V A L L LSL N + + P +SLE L L+ I L
Sbjct: 155 QF---VGRSAFQYLPKLHTLSL---NGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGM 208
Query: 240 LANLTALRVLDVGGN-------CRRCDHAPNPCMECPRHFPQLHPDTFSHLSRLEGLVLK 292
L LRVL++ N RC ++ R + ++ DTFS LS L+ L L
Sbjct: 209 CQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIW-EIGADTFSQLSSLQALDLS 267
Query: 293 DSSLSWLNASWFRGLGNLRVLDLSENFLYKCITKTKAFQGLTQLRKLNLSFNYQKRVSFA 352
+++ ++ F L +L LDL++N L T GL L L L N +F+
Sbjct: 268 WNAIRSIHPEAFSTLHSLVKLDLTDNQL-----TTLPLAGLGGLMHLKLKGNLALSQAFS 322
Score = 47.8 bits (112), Expect = 5e-05
Identities = 87/340 (25%), Positives = 138/340 (40%), Gaps = 74/340 (21%)
Query: 114 IEPSTFLAVPTLEELNLSYNNIMTVPALPKSLISLSLSHTNILMLDSASLAGLHALRFLF 173
++P F + LEEL LS N++ +P S L ILML + L G+ A
Sbjct: 38 LQPGLFHHLRFLEELRLSGNHLSHIPGQAFS----GLYSLKILMLQNNQLGGIPA----- 88
Query: 174 MDGNCYYKNPCRQALEV-------APGALLGLGNLTHLSLKYNNLTVVPRNL---PSSLE 223
++ P Q+L++ P A+ LG L L NN+ +P L+
Sbjct: 89 ---EALWELPSLQSLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQ 145
Query: 224 YLLLSYNRIVKLAPEDLANLTALRVLDVGGNCRRCDHAPNPCMECPRHFPQLHPDTFSHL 283
+ N I + L L L + G M+ + FP L T
Sbjct: 146 TIHFYDNPIQFVGRSAFQYLPKLHTLSLNG-----------AMDI-QEFPDLKGTT---- 189
Query: 284 SRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSEN------FLYKCITKTK--------- 328
LE L L + + L + + L LRVL+LS N L++C +
Sbjct: 190 -SLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIW 248
Query: 329 -----AFQGLTQLRKLNLSFNYQKRVSFAHLSLAP-SFGSLVALKELDMHGIFFRSLDET 382
F L+ L+ L+LS+N A S+ P +F +L +L +LD+ + ++
Sbjct: 249 EIGADTFSQLSSLQALDLSWN-------AIRSIHPEAFSTLHSLVKLDL------TDNQL 295
Query: 383 TLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYVDL 422
T PLA L L L+L+ N + +Q +FP LR +++
Sbjct: 296 TTLPLAGLGGLMHLKLKGN-LALSQAFSKDSFPKLRILEV 334
>gi|62912470 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 1 [Homo sapiens]
Length = 967
Score = 83.2 bits (204), Expect = 1e-15
Identities = 150/547 (27%), Positives = 217/547 (39%), Gaps = 119/547 (21%)
Query: 34 PCELQPHGLV---NCNWLFLKSVPHFSMAAPRGNVTSLS----LSSNRIHHLHDSDFAHL 86
PC Q G++ +C+ L L +VP G++ L+ LS N + L F HL
Sbjct: 38 PCHCQEDGIMLSADCSELGLSAVP--------GDLDPLTAYLDLSMNNLTELQPGLFHHL 89
Query: 87 PSLRHLNLKWNCPPVGLSPMHFPCHMTIEPS-TFLAVPTLEELNLSYNNIMTVPA----- 140
L L L N H++ P F + +L+ L L N + +PA
Sbjct: 90 RFLEELRLSGN-------------HLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWE 136
Query: 141 LPKSLISLSLSHTNILMLDSASLAGLHALRFLFMDGNCYYKNPCRQALEVAPGALLGLGN 200
LP SL SL L I ++ S GL +LR L++D N + P R
Sbjct: 137 LP-SLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRAL------------- 182
Query: 201 LTHLSLKYNNLTVVPRNLPSSLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGNCRRCDH 260
NLP +L+ + L+ NRI + NLT+L VL + N R H
Sbjct: 183 ---------------NNLP-ALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNN--RIQH 224
Query: 261 APNPCMECPRHFPQLHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSENFL 320
L +F L LE L L + L + R LG L+ L N +
Sbjct: 225 --------------LGTHSFEGLHNLETLDLNYNKLQEFPVA-IRTLGRLQELGFHNNNI 269
Query: 321 YKCITKTKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSFGSLVALKELDMHGIFFRSLD 380
K I + KAF G L+ ++ Y + F S +F L L L ++G ++D
Sbjct: 270 -KAIPE-KAFMGNPLLQTIHF---YDNPIQFVGRS---AFQYLPKLHTLSLNG----AMD 317
Query: 381 ETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYVDLSDNRISGASELTATMGEA 440
L L+ L L I G+ + P LR ++LS N+I E ++
Sbjct: 318 IQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQI----EELPSLHRC 373
Query: 441 DGGEKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLSRNNLVTVQPEMFAQLSHLQC 500
E++ LQ + DT S S+L LDLS N + ++ PE F+ L L
Sbjct: 374 QKLEEIGLQHNRIWEIGADTFS------QLSSLQ-ALDLSWNAIRSIHPEAFSTLHSLVK 426
Query: 501 LRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLD----LYHEHSFTELPRLEALDLSYNS 556
L L+ N ++ LPL GL L H KL L S P+L L++ Y
Sbjct: 427 LDLTDNQLTT-------LPLAGLG--GLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAY 477
Query: 557 Q--PFGM 561
Q P+GM
Sbjct: 478 QCCPYGM 484
Score = 78.2 bits (191), Expect = 4e-14
Identities = 121/439 (27%), Positives = 175/439 (39%), Gaps = 73/439 (16%)
Query: 274 QLHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSENFLYKCITKTKAFQGL 333
+L P F HL LE L L + LS + F GL +L++L L N L +A L
Sbjct: 80 ELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGG--IPAEALWEL 137
Query: 334 TQLRKLNLSFNYQKRVSFAHLSLAP--SFGSLVALKELDMHGIFFRSLDETTLRPLARLP 391
L+ L L N +SL P SF L +L+ L + +L E +R L LP
Sbjct: 138 PSLQSLRLDANL--------ISLVPERSFEGLSSLRHLWLDD---NALTEIPVRALNNLP 186
Query: 392 MLQTLRLQMNFINQAQLGIFRAFPGLRYVDLSDNRISGASELTATMGEADGGEKVWLQPG 451
LQ + L +N I+ F+ L + L +NRI T + E + L
Sbjct: 187 ALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLG--THSFEGLHNLETLDLNYN 244
Query: 452 DLAPAPVDTPSSEDFRPNCSTLNFTLDLSRNNLVTVQPEMFAQLSHLQCLRLSHNCISQA 511
L PV + + L NN+ + + F LQ + N I Q
Sbjct: 245 KLQEFPVAIRTLGRLQ--------ELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPI-QF 295
Query: 512 VNGS--QFLP---------------------LTGLQVLDLSHNKLDLYHEHSFTELPRLE 548
V S Q+LP T L++L L+ + L +LPRL
Sbjct: 296 VGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLR 355
Query: 549 ALDLSYNSQPFGMQGVGHNFSFVAHLRTLRHLSLAHN---NIHSQVSQQLCSTSLRALDF 605
L+LS+N + + L + L HN I + QL +SL+ALD
Sbjct: 356 VLELSHNQI--------EELPSLHRCQKLEEIGLQHNRIWEIGADTFSQL--SSLQALDL 405
Query: 606 SGNALGHMWAEGDLYLHFFQGLSGLIWLDLSQNRLHTLLPQTLRNLPKSLQVLRLRDNYL 665
S NA+ + E F L L+ LDL+ N+L TL L L L+L+ N L
Sbjct: 406 SWNAIRSIHPEA------FSTLHSLVKLDLTDNQLTTLPLAGL----GGLMHLKLKGN-L 454
Query: 666 AFFKWWSLHFLPKLEVLDL 684
A + +S PKL +L++
Sbjct: 455 ALSQAFSKDSFPKLRILEV 473
Score = 77.0 bits (188), Expect = 8e-14
Identities = 105/403 (26%), Positives = 165/403 (40%), Gaps = 65/403 (16%)
Query: 391 PMLQTLRLQMNFINQAQLGIFRAFPGLRYVDLSDNRISGASELTATMGEADGG----EKV 446
P+ L L MN + + Q G+F L + LS N +S G+A G + +
Sbjct: 66 PLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIP------GQAFSGLYSLKIL 119
Query: 447 WLQPGDLAPAPVDT----PSSEDFRPNCSTLNFT-------------LDLSRNNLVTVQP 489
LQ L P + PS + R + + ++ L L N L +
Sbjct: 120 MLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPV 179
Query: 490 EMFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEA 549
L LQ + L+ N IS + F LT L VL L +N++ HSF L LE
Sbjct: 180 RALNNLPALQAMTLALNRISH-IPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLET 238
Query: 550 LDLSYNS-QPFGMQGVGHNFSFVAHLRTLRHLSLAHNNIHSQVSQQLCSTSL-RALDFSG 607
LDL+YN Q F + + L L+ L +NNI + + L + + F
Sbjct: 239 LDLNYNKLQEFPVA--------IRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYD 290
Query: 608 NALGHMWAEGDLYLHFFQGLSGLIWLDLSQNRLHTLLPQTLRNLPK--------SLQVLR 659
N + F G S +L +LHTL ++ + SL++L
Sbjct: 291 NPIQ------------FVGRSAFQYLP----KLHTLSLNGAMDIQEFPDLKGTTSLEILT 334
Query: 660 LRDNYLAFFKWWSLHFLPKLEVLDLAGNQLKALTNGSLPAGTRLRRLDVSCNSISFVAPG 719
L + LP+L VL+L+ NQ++ L SL +L + + N I +
Sbjct: 335 LTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELP--SLHRCQKLEEIGLQHNRIWEIGAD 392
Query: 720 FFSKAKELRELNLSANALKTVDHSWFGPLASALQILDVSANPL 762
FS+ L+ L+LS NA++++ F L S ++ LD++ N L
Sbjct: 393 TFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVK-LDLTDNQL 434
>gi|38348406 leucine rich repeat containing 33 [Homo sapiens]
Length = 692
Score = 82.8 bits (203), Expect = 2e-15
Identities = 150/540 (27%), Positives = 217/540 (40%), Gaps = 81/540 (15%)
Query: 243 LTALRVLDVGGNCRRCDHAPNPCMECPRHFPQLHPDTFSHLSRLEGLVLKDSSLSWLNAS 302
L LR LD+ GN D A +LS L + L +++ L+ S
Sbjct: 131 LPGLRRLDLSGNALTEDMAAL---------------MLQNLSSLRSVSLAGNTIMRLDDS 175
Query: 303 WFRGLGNLRVLDLSENFLYKCITKTKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSFGS 362
F GL LR LDL N++++ + AF GL +LR LNL+FN +L FG
Sbjct: 176 VFEGLERLRELDLQRNYIFE--IEGGAFDGLAELRHLNLAFN--------NLPCIVDFG- 224
Query: 363 LVALKELDMHGIFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFP---GLRY 419
L L + + + L+ L+TL L N QL F P LR
Sbjct: 225 ---LTRLRVLNVSYNVLEWFLATGGEAAFELETLDLSHN-----QLLFFPLLPQYSKLRT 276
Query: 420 VDLSDNRISGASELTATMGEADGGEKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDL 479
+ L DN + +L T + + L G++ + E + + L F LD+
Sbjct: 277 LLLRDNNMGFYRDLYNTSSPREMVAQFLLVDGNVTNITTVSLWEEFSSSDLADLRF-LDM 335
Query: 480 SRNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLYH-- 537
S+N + ++ L L L NC+ ++ + P L LDLSHN+L H
Sbjct: 336 SQNQFQYLPDGFLRKMPSLSHLNLHQNCL-MTLHIREHEPPGALTELDLSHNQLSELHLA 394
Query: 538 EHSFTELPRLEALDLSYNSQPFGMQGVGHNFSFVAHLRTLRHLSLAHNNI--------HS 589
+ L L +LS N Q +G A+ R + L ++HN I
Sbjct: 395 PGLASCLGSLRLFNLSSN------QLLGVPPGLFANARNITTLDMSHNQISLCPLPAASD 448
Query: 590 QVSQQLC-----STSLRALDFSGNALGHMWAEGDLYLHFFQGLSGLIWLDLSQN---RLH 641
+V C SLR+L G LG A D FQG S L +LDLS N
Sbjct: 449 RVGPPSCVDFRNMASLRSLSLEGCGLG---ALPDCP---FQGTS-LTYLDLSSNWGVLNG 501
Query: 642 TLLPQTLRNLPKSLQVLRLRDNYL-AFFKWWSLHFLPKLEVLDLAGNQLKALT--NGSLP 698
+L P L+++ LQVL LR+ L + F L LDL+GN L GSL
Sbjct: 502 SLAP--LQDVAPMLQVLSLRNMGLHSSFMALDFSGFGNLRDLDLSGNCLTTFPRFGGSL- 558
Query: 699 AGTRLRRLDVSCNSISFVAPGFFSK--AKELRELNLSANALKTVDHSWFGPLASALQILD 756
L LD+ NS++ + S+ ++ LR + LS N +G L + D
Sbjct: 559 ---ALETLDLRRNSLTALPQKAVSEQLSRGLRTIYLSQNPYDCCGVDGWGALQHGQTVAD 615
Score = 71.2 bits (173), Expect = 5e-12
Identities = 104/379 (27%), Positives = 155/379 (40%), Gaps = 53/379 (13%)
Query: 391 PMLQTLRLQMNFINQAQLGIFRAFPGLRYVDLSDNRISGASELTATMGEADGGEKVWLQP 450
P+L++L L + + G F+ LR + L DN +S E TA A G L+
Sbjct: 81 PLLESLSLHSCHLERISRGAFQEQGHLRSLVLGDNCLSENYEETAAALHALPG----LRR 136
Query: 451 GDLAPAPVDTPSSEDFRPNCSTLNFTLDLSRNNLVTVQPEMFAQLSHLQCLRLSHNCISQ 510
DL+ + + N S+L ++ L+ N ++ + +F L L+ L L N I +
Sbjct: 137 LDLSGNALTEDMAALMLQNLSSLR-SVSLAGNTIMRLDDSVFEGLERLRELDLQRNYIFE 195
Query: 511 AVNGS--------------QFLP------LTGLQVLDLSHNKLDLYHEHSFTELPRLEAL 550
G+ LP LT L+VL++S+N L+ + LE L
Sbjct: 196 IEGGAFDGLAELRHLNLAFNNLPCIVDFGLTRLRVLNVSYNVLEWFLATGGEAAFELETL 255
Query: 551 DLSYNSQPFGMQGVGHNFSFVAHLRTLRHLSLAHNNIHSQVSQQLCSTS------LRALD 604
DLS+N F F + LR L L NN+ + L +TS + L
Sbjct: 256 DLSHNQLLF--------FPLLPQYSKLRTLLLRDNNM--GFYRDLYNTSSPREMVAQFLL 305
Query: 605 FSGNALG----HMWAEGDLYLHFFQGLSGLIWLDLSQNRLHTLLPQTLRNLPKSLQVLRL 660
GN +W E L+ L +LD+SQN+ L LR +P SL L L
Sbjct: 306 VDGNVTNITTVSLWEE-----FSSSDLADLRFLDMSQNQFQYLPDGFLRKMP-SLSHLNL 359
Query: 661 RDNYLAFFKWWSLHFLPKLEVLDLAGNQLKA--LTNGSLPAGTRLRRLDVSCNSISFVAP 718
N L L LDL+ NQL L G LR ++S N + V P
Sbjct: 360 HQNCLMTLHIREHEPPGALTELDLSHNQLSELHLAPGLASCLGSLRLFNLSSNQLLGVPP 419
Query: 719 GFFSKAKELRELNLSANAL 737
G F+ A+ + L++S N +
Sbjct: 420 GLFANARNITTLDMSHNQI 438
Score = 70.5 bits (171), Expect = 8e-12
Identities = 92/288 (31%), Positives = 124/288 (43%), Gaps = 33/288 (11%)
Query: 495 LSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEALDLSY 554
L L+ L LS N +++ + L+ L+ + L+ N + + F L RL LDL
Sbjct: 131 LPGLRRLDLSGNALTEDMAALMLQNLSSLRSVSLAGNTIMRLDDSVFEGLERLRELDLQR 190
Query: 555 NSQPFGMQGVGHNFSFVAHLRTLRHLSLAHNNIHSQVSQQLCSTSLRALDFSGNALGHMW 614
N F ++G + L LRHL+LA NN+ V L T LR L+ S N L
Sbjct: 191 N-YIFEIEGGAFD-----GLAELRHLNLAFNNLPCIVDFGL--TRLRVLNVSYNVLEWFL 242
Query: 615 AEGDLYLHFFQGLSGLIWLDLSQNRL--HTLLPQTLRNLPKSLQVLRLRDNYLAFFKWWS 672
A G + L LDLS N+L LLPQ + L+ L LRDN + F++
Sbjct: 243 ATGG------EAAFELETLDLSHNQLLFFPLLPQYSK-----LRTLLLRDNNMGFYRDLY 291
Query: 673 LHFLPKLEVLD--LAGNQLKALTNGSLPAG------TRLRRLDVSCNSISFVAPGFFSKA 724
P+ V L + +T SL LR LD+S N ++ GF K
Sbjct: 292 NTSSPREMVAQFLLVDGNVTNITTVSLWEEFSSSDLADLRFLDMSQNQFQYLPDGFLRKM 351
Query: 725 KELRELNLSANALKTVDHSWFGPLASALQILDVSAN---PLHCACGAA 769
L LNL N L T+ P AL LD+S N LH A G A
Sbjct: 352 PSLSHLNLHQNCLMTLHIREHEP-PGALTELDLSHNQLSELHLAPGLA 398
Score = 67.4 bits (163), Expect = 7e-11
Identities = 168/657 (25%), Positives = 245/657 (37%), Gaps = 135/657 (20%)
Query: 31 AFLPCELQPHG-LVNCNWLFLKSVPHFSMAAPRGNVTSLSLSSNRIHHLHDSDFAHLPSL 89
A +P L PH ++ + LK++ + S+ P + SLSL S + + F L
Sbjct: 49 ASVPSSLPPHARMLTLDANPLKTLWNHSLQ-PYPLLESLSLHSCHLERISRGAFQEQGHL 107
Query: 90 RHLNLKWNCPPVGLSPMHFPCHMTIEPSTFLAVPTLEELNLSYNNIMTVPALP-----KS 144
R L L NC H A+P L L+LS N + A S
Sbjct: 108 RSLVLGDNCLSENYEETAAALH---------ALPGLRRLDLSGNALTEDMAALMLQNLSS 158
Query: 145 LISLSLSHTNILMLDSASLAGLHALRFLFMDGNCYYKNPCRQALEVAPGALLGLGNLTHL 204
L S+SL+ I+ LD + GL LR L + N + E+ GA GL L HL
Sbjct: 159 LRSVSLAGNTIMRLDDSVFEGLERLRELDLQRNYIF--------EIEGGAFDGLAELRHL 210
Query: 205 SLKYNNLTVVPRNLPSSLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGNCRRCDHAPNP 264
+L +NNL + + L L +SYN + L LD+ N
Sbjct: 211 NLAFNNLPCIVDFGLTRLRVLNVSYNVLEWFLATGGEAAFELETLDLSHNQL-------- 262
Query: 265 CMECPRHFPQLHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNL-RVLDLSENFLYKC 323
FP L S+L L+L+D+ N ++R L N ++ FL
Sbjct: 263 -----LFFPLL-----PQYSKLRTLLLRDN-----NMGFYRDLYNTSSPREMVAQFLL-- 305
Query: 324 ITKTKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSFGSLVALKELDMHGIFFRSLDETT 383
+T + ++L + S L L+ LDM F+ L +
Sbjct: 306 -----VDGNVTNITTVSLWEEF-------------SSSDLADLRFLDMSQNQFQYLPDGF 347
Query: 384 LRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYVDLSDNRISGASELTATMGEADGG 443
LR ++P L L L N + + L +DLS N++S
Sbjct: 348 LR---KMPSLSHLNLHQNCLMTLHIREHEPPGALTELDLSHNQLS--------------- 389
Query: 444 EKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLSRNNLVTVQPEMFAQLSHLQCLRL 503
++ L PG +C +LS N L+ V P +FA ++ L +
Sbjct: 390 -ELHLAPG---------------LASCLGSLRLFNLSSNQLLGVPPGLFANARNITTLDM 433
Query: 504 SHNCISQA-----------VNGSQFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEALDL 552
SHN IS + F + L+ L L L + F + L LDL
Sbjct: 434 SHNQISLCPLPAASDRVGPPSCVDFRNMASLRSLSLEGCGLGALPDCPF-QGTSLTYLDL 492
Query: 553 SYNSQPFG-MQGVGHNFSFVAHLRTLRHLSLAHNNIHSQVSQQLCSTSLRALDFSG-NAL 610
S N +G + G VA + L+ LSL + +HS S ALDFSG L
Sbjct: 493 SSN---WGVLNGSLAPLQDVAPM--LQVLSLRNMGLHS---------SFMALDFSGFGNL 538
Query: 611 GHMWAEGDLYLHF--FQGLSGLIWLDLSQNRLHTLLPQ--TLRNLPKSLQVLRLRDN 663
+ G+ F F G L LDL +N L T LPQ L + L+ + L N
Sbjct: 539 RDLDLSGNCLTTFPRFGGSLALETLDLRRNSL-TALPQKAVSEQLSRGLRTIYLSQN 594
Score = 45.8 bits (107), Expect = 2e-04
Identities = 51/163 (31%), Positives = 68/163 (41%), Gaps = 31/163 (19%)
Query: 600 LRALDFSGNALGHMWAEGDLYLHFFQGLSGLIWLDLSQNRLHTLLPQTLRNLPKSLQVLR 659
LR+L N L + E LH L GL LDLS N L + + L
Sbjct: 107 LRSLVLGDNCLSENYEETAAALH---ALPGLRRLDLSGNAL-----------TEDMAALM 152
Query: 660 LRDNYLAFFKWWSLHFLPKLEVLDLAGNQLKALTNGSLPAGTRLRRLDVSCNSISFVAPG 719
L++ L L + LAGN + L + RLR LD+ N I + G
Sbjct: 153 LQN-------------LSSLRSVSLAGNTIMRLDDSVFEGLERLRELDLQRNYIFEIEGG 199
Query: 720 FFSKAKELRELNLSANALKTVDHSWFGPLASALQILDVSANPL 762
F ELR LNL+ N L + FG + L++L+VS N L
Sbjct: 200 AFDGLAELRHLNLAFNNLPCIVD--FG--LTRLRVLNVSYNVL 238
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.138 0.437
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,469,153
Number of Sequences: 37866
Number of extensions: 1839688
Number of successful extensions: 9643
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 182
Number of HSP's successfully gapped in prelim test: 117
Number of HSP's that attempted gapping in prelim test: 5365
Number of HSP's gapped (non-prelim): 1980
length of query: 1032
length of database: 18,247,518
effective HSP length: 112
effective length of query: 920
effective length of database: 14,006,526
effective search space: 12886003920
effective search space used: 12886003920
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.