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Search of human proteins with 83921609
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|83921609 hypothetical protein LOC127254 [Homo sapiens]
(1530 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|83921609 hypothetical protein LOC127254 [Homo sapiens] 3015 0.0
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] 116 1e-25
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 103 2e-21
gi|150170670 piccolo isoform 2 [Homo sapiens] 87 1e-16
gi|150378539 piccolo isoform 1 [Homo sapiens] 87 1e-16
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens] 84 1e-15
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 81 9e-15
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 81 9e-15
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 81 9e-15
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 81 9e-15
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 81 9e-15
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 81 9e-15
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 81 9e-15
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 81 9e-15
gi|156104908 myosin heavy chain 6 [Homo sapiens] 79 4e-14
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 76 3e-13
gi|87299628 biorientation of chromosomes in cell division 1-like... 74 1e-12
gi|38176300 nestin [Homo sapiens] 73 2e-12
gi|21493022 A kinase (PRKA) anchor protein 12 isoform 1 [Homo sa... 72 4e-12
gi|21493024 A kinase (PRKA) anchor protein 12 isoform 2 [Homo sa... 72 4e-12
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 71 7e-12
gi|148746195 trichohyalin [Homo sapiens] 70 1e-11
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 69 3e-11
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 69 3e-11
gi|7657138 golgi integral membrane protein 4 [Homo sapiens] 69 3e-11
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 68 6e-11
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 68 6e-11
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 67 1e-10
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 67 1e-10
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 67 1e-10
>gi|83921609 hypothetical protein LOC127254 [Homo sapiens]
Length = 1530
Score = 3015 bits (7816), Expect = 0.0
Identities = 1530/1530 (100%), Positives = 1530/1530 (100%)
Query: 1 MSHSHPAGLLAAYNSLMDKHLAGYFNNTRIRRHLLRSGLITRSGRILSEKEYKLNMMKRD 60
MSHSHPAGLLAAYNSLMDKHLAGYFNNTRIRRHLLRSGLITRSGRILSEKEYKLNMMKRD
Sbjct: 1 MSHSHPAGLLAAYNSLMDKHLAGYFNNTRIRRHLLRSGLITRSGRILSEKEYKLNMMKRD 60
Query: 61 HQKYIRECLAQAIFHKVLDMERYHQLEIKKKLETLARKERIQRFKGEHTRRSVENNMPIL 120
HQKYIRECLAQAIFHKVLDMERYHQLEIKKKLETLARKERIQRFKGEHTRRSVENNMPIL
Sbjct: 61 HQKYIRECLAQAIFHKVLDMERYHQLEIKKKLETLARKERIQRFKGEHTRRSVENNMPIL 120
Query: 121 SPHPPVGPKSNRGHSVLVDEGHSSPLALTAPRPYTAPGNMQPPIRLQPLPSNPAVETVPK 180
SPHPPVGPKSNRGHSVLVDEGHSSPLALTAPRPYTAPGNMQPPIRLQPLPSNPAVETVPK
Sbjct: 121 SPHPPVGPKSNRGHSVLVDEGHSSPLALTAPRPYTAPGNMQPPIRLQPLPSNPAVETVPK 180
Query: 181 VTSRSRSKTSLLENEALFPIGGKKAVMKFRNSIGNSQRMNSYQLPNINSYMMPIPPPLPP 240
VTSRSRSKTSLLENEALFPIGGKKAVMKFRNSIGNSQRMNSYQLPNINSYMMPIPPPLPP
Sbjct: 181 VTSRSRSKTSLLENEALFPIGGKKAVMKFRNSIGNSQRMNSYQLPNINSYMMPIPPPLPP 240
Query: 241 TGKITRENRSETWRRRRFRPTTAPNGLEPLLTKDSRRIHKTSLHSNAAITMIYLGKNVHL 300
TGKITRENRSETWRRRRFRPTTAPNGLEPLLTKDSRRIHKTSLHSNAAITMIYLGKNVHL
Sbjct: 241 TGKITRENRSETWRRRRFRPTTAPNGLEPLLTKDSRRIHKTSLHSNAAITMIYLGKNVHL 300
Query: 301 SSDNPDFRDEIKVYQQHCGGENLCVYKGKLLEKETFQFISKRHHGFPFSLTFFLNGMQVN 360
SSDNPDFRDEIKVYQQHCGGENLCVYKGKLLEKETFQFISKRHHGFPFSLTFFLNGMQVN
Sbjct: 301 SSDNPDFRDEIKVYQQHCGGENLCVYKGKLLEKETFQFISKRHHGFPFSLTFFLNGMQVN 360
Query: 361 RLSSCCEYKHRKGSRLGGKRGYFGFVCVERSSPCYKCIIAMGLDKKPSLPKSRKEKSTEK 420
RLSSCCEYKHRKGSRLGGKRGYFGFVCVERSSPCYKCIIAMGLDKKPSLPKSRKEKSTEK
Sbjct: 361 RLSSCCEYKHRKGSRLGGKRGYFGFVCVERSSPCYKCIIAMGLDKKPSLPKSRKEKSTEK 420
Query: 421 GEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVTAVEEMTSKGK 480
GEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVTAVEEMTSKGK
Sbjct: 421 GEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVTAVEEMTSKGK 480
Query: 481 PGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPLDDKKDNLDP 540
PGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPLDDKKDNLDP
Sbjct: 481 PGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPLDDKKDNLDP 540
Query: 541 EKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSSRSHPYSSDSEDESAV 600
EKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSSRSHPYSSDSEDESAV
Sbjct: 541 EKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSSRSHPYSSDSEDESAV 600
Query: 601 GDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIEDQEITKADVETKPMP 660
GDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIEDQEITKADVETKPMP
Sbjct: 601 GDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIEDQEITKADVETKPMP 660
Query: 661 IDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSKLWEESTAQVKDKKAGLP 720
IDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSKLWEESTAQVKDKKAGLP
Sbjct: 661 IDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSKLWEESTAQVKDKKAGLP 720
Query: 721 GLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQKTYTLEKKEAMEEDEA 780
GLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQKTYTLEKKEAMEEDEA
Sbjct: 721 GLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQKTYTLEKKEAMEEDEA 780
Query: 781 PQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAE 840
PQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAE
Sbjct: 781 PQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAE 840
Query: 841 GAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLE 900
GAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLE
Sbjct: 841 GAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLE 900
Query: 901 KAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPME 960
KAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPME
Sbjct: 901 KAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPME 960
Query: 961 DTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEASRMQVSEGSPEEGSLAK 1020
DTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEASRMQVSEGSPEEGSLAK
Sbjct: 961 DTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEASRMQVSEGSPEEGSLAK 1020
Query: 1021 EAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEV 1080
EAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEV
Sbjct: 1021 EAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEV 1080
Query: 1081 TRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEASELSDN 1140
TRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEASELSDN
Sbjct: 1081 TRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEASELSDN 1140
Query: 1141 PGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGERLSEARDTEHKDREELSSRE 1200
PGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGERLSEARDTEHKDREELSSRE
Sbjct: 1141 PGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGERLSEARDTEHKDREELSSRE 1200
Query: 1201 NRALKEGHRQDGEGALAAPEAEPAGKVQAPEGLIPATGQAEELAAKDHDSCAGLEGRAEG 1260
NRALKEGHRQDGEGALAAPEAEPAGKVQAPEGLIPATGQAEELAAKDHDSCAGLEGRAEG
Sbjct: 1201 NRALKEGHRQDGEGALAAPEAEPAGKVQAPEGLIPATGQAEELAAKDHDSCAGLEGRAEG 1260
Query: 1261 QGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGDM 1320
QGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGDM
Sbjct: 1261 QGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGDM 1320
Query: 1321 EGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEEREVLAGSETAEEKTIANKASSFSD 1380
EGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEEREVLAGSETAEEKTIANKASSFSD
Sbjct: 1321 EGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEEREVLAGSETAEEKTIANKASSFSD 1380
Query: 1381 VAEEETWHQQDELVGKTAAAGKVVVEELARSGEEVPAAEEMTVTYTTEAGVGTPGALERK 1440
VAEEETWHQQDELVGKTAAAGKVVVEELARSGEEVPAAEEMTVTYTTEAGVGTPGALERK
Sbjct: 1381 VAEEETWHQQDELVGKTAAAGKVVVEELARSGEEVPAAEEMTVTYTTEAGVGTPGALERK 1440
Query: 1441 TSGLGQEQEEGSEGQEAATGSGDGRQETGAAEKFRLGLSREGERELSPESLQAMATLPVK 1500
TSGLGQEQEEGSEGQEAATGSGDGRQETGAAEKFRLGLSREGERELSPESLQAMATLPVK
Sbjct: 1441 TSGLGQEQEEGSEGQEAATGSGDGRQETGAAEKFRLGLSREGERELSPESLQAMATLPVK 1500
Query: 1501 PDFTETREKQQHMVQGESETADVSPNNMQV 1530
PDFTETREKQQHMVQGESETADVSPNNMQV
Sbjct: 1501 PDFTETREKQQHMVQGESETADVSPNNMQV 1530
>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
Length = 2400
Score = 116 bits (291), Expect = 1e-25
Identities = 262/1182 (22%), Positives = 460/1182 (38%), Gaps = 194/1182 (16%)
Query: 415 EKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAK------FSAQEIKT--GLK 466
E E+ E ++A + + E + + +++E K + +E KT GL+
Sbjct: 1273 EDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQ 1332
Query: 467 EVVTAVEEMTSKGKPGQEV----LEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQA--- 519
E +EE GQ+ LE+ +E + EE +++E K+G + +G+A
Sbjct: 1333 EEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGEALEE 1392
Query: 520 DVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKT 579
++ G+P+ + ++ ++ SE SS PD + + +D+ ++E++ +
Sbjct: 1393 GLKEEGLPE------EGSVHGQELSEASS---PDGKGSQEDD-------PVQEEEAGRAS 1436
Query: 580 ASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEES 639
AS+ + +E S + + TD S E R+S SQ +KP + + +E
Sbjct: 1437 ASAEPCPAEGTEEPTEPPSHLSE----TDPSASE--RQSGSQLEPGLEKPPGATMMGQEH 1490
Query: 640 LEIEIED--QEITKADVETKPMPIDESFENVLKEGTEKG-----TQEIAE-----GLSEK 687
+ + E + + + + D + +VL + TEK +AE GL +
Sbjct: 1491 TQAQPTQGAAERSSSVACSAALDCDPIWVSVLLKKTEKAFLAHLASAVAELRARWGLQDN 1550
Query: 688 SGKHVSAEEKEKDKSKLWEESTAQVKDKKAGLPG--LEEGGKDSLPLAYVL--------- 736
A E ++D ++ ++ST + K G G + E +++L +L
Sbjct: 1551 DLLDQMAAELQQDVAQRLQDSTKRELQKLQGRAGRMVLEPPREALTGELLLQTQQRRHRL 1610
Query: 737 ------------ALGAPTMNFMVDETAAINSNKESQQ---------------LVQKTYTL 769
LG ++F +++ A+++ SQ + +K +
Sbjct: 1611 RGLRNLSAFSERTLGLGPLSFTLEDEPALSTALGSQLGEEAEGEEFCPCEACVRKKVSPM 1670
Query: 770 EKKEAMEEDEAPQHRDAD---IVQGKGEAALWGEA-----GAVHEAPLRAWKPTAEQPEL 821
K M P D I+Q K GEA G H P + L
Sbjct: 1671 SPKATMGATRGPIKEAFDLQQILQRKRGEHTDGEAAEVAPGKTHTDPTSTRTVQGAEGGL 1730
Query: 822 AEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQAL 881
++ PG++ G +G EG +RL +G+A DA+ + E +
Sbjct: 1731 GPGLSQ----GPGVDEGEDG----EGSQRLNRDKDPKLGEAEG-DAMAQER-EGKTHNSE 1780
Query: 882 MLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSD 941
E +A EGE E+ + + E AA + + AEG A
Sbjct: 1781 TSAGSELGEAEQEGEGISERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEA 1840
Query: 942 VGESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSP----- 996
GE++ E+ E + +G + G +P E E E P
Sbjct: 1841 EGEAQPES----------EGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDV 1890
Query: 997 FTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDL 1056
T EAE SEG+ E KEA E VE E TE E E + E E +
Sbjct: 1891 ETPEAEWEVQPESEGA-EAPEAEKEAQPETESVEALE--TEGEDEPESEGAEAQEAE-EA 1946
Query: 1057 ARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETK 1116
A+E +P++ + ++ EE + +D +A + E + + EGE + E E+ +
Sbjct: 1947 AQEAEGQTQPESEVIESQEAEEEAQPES--EDVEALEVEVETQEAEGEAQPE---SEDVE 2001
Query: 1117 APPNE-MGSDAENEAPVEASELSDNPGLLGEDSLK---ETVVPIFEA--------TPGFE 1164
AP E +AE EA E+ + P GE++ + ET +A P E
Sbjct: 2002 APEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAE 2061
Query: 1165 KSLENITALRKEGGGERLSEARDTEHKDREELSSRENRALK----EGHRQDGEGALAAPE 1220
+ + +E GE E+ D + ++ E + E+ ++ EG Q EG + APE
Sbjct: 2062 EEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEG-IEAPE 2120
Query: 1221 AEPAGK-----VQAPEGLIPATGQAEELAAKDHDSCA-----GLEGR-AEGQG-----GV 1264
E + ++APE A ++E + A+D + A G+E + AE + GV
Sbjct: 2121 TEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGV 2180
Query: 1265 DVVLRTQEAVAEEDPIMAEKFREEAVD-----EDPEEEEDKECTLETEAMQDRNSEGDGD 1319
+ EA E + I A + EA E PE EE E E E ++ +EG+
Sbjct: 2181 EAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEE--EAQPEPEGVETPEAEGEAQ 2238
Query: 1320 MEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEEREV---------LAGSETAEEK- 1369
E EG TQ G + + +V G G++ E + V G +T ++
Sbjct: 2239 PESEGETQ------GEKKGSPQVSLGDGQSEEASESSSPVPEDRPTPPPSPGGDTPHQRP 2292
Query: 1370 -----TIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEELARSGEEVPAAEEMTVT 1424
+++ASS+ + ++++ + D ++G T + + E + +
Sbjct: 2293 GSQTGPSSSRASSWGNCWQKDS--ENDHVLGDTRSPDAKSTGTPHAERKATRMYPESSTS 2350
Query: 1425 YTTEAGVG--TPGALERKTSGLGQEQEEGSEGQEAATGSGDG 1464
EA +G TP + L ++Q GS A G DG
Sbjct: 2351 EQEEAPLGSRTPEQGASEGYDLQEDQALGSLAPTEAVGRADG 2392
Score = 86.3 bits (212), Expect = 2e-16
Identities = 236/1049 (22%), Positives = 377/1049 (35%), Gaps = 190/1049 (18%)
Query: 609 SSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIEDQEITKADVETKPMPIDESFENV 668
++ ++ A R S ++ + ++ + + ++E +++E E +E T+ + + E +
Sbjct: 1270 ATNEDEAERDSEEQRASSNLEQLAENTVQEEVQLE-ETKEGTEGE------GLQEEAVQL 1322
Query: 669 LKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSKLWE----------ESTAQVKDKKAG 718
+ TE+G QE EG+ + K E +++++++L E E Q+++ K G
Sbjct: 1323 EETKTEEGLQE--EGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEG 1380
Query: 719 LPG------LEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQKTYTLEKK 772
G LEEG K+ G P E +++ + S+ +
Sbjct: 1381 PEGGLQGEALEEGLKEE---------GLP-------EEGSVHGQELSEA------SSPDG 1418
Query: 773 EAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAP--LRAWKPTAEQPELAEEFTEKRE 830
+ +ED+ Q +A E E P L P+A + + + E
Sbjct: 1419 KGSQEDDPVQEEEAGRASASAEPCPAEGTEEPTEPPSHLSETDPSASERQSGSQLEPGLE 1478
Query: 831 IPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKD------AVGLSKDEAPEKQALMLT 884
PPG + +A+ + E S + +AA D +V L K E L
Sbjct: 1479 KPPGATMMGQEHTQAQPTQGAAERSSS-VACSAALDCDPIWVSVLLKKTEKAFLAHLASA 1537
Query: 885 VLET------------DKAASEGEQGLEKAV--------------------------LAN 906
V E D+ A+E +Q + + + L
Sbjct: 1538 VAELRARWGLQDNDLLDQMAAELQQDVAQRLQDSTKRELQKLQGRAGRMVLEPPREALTG 1597
Query: 907 EAAALNLEHLHEVAALREAA--------------TSEEGEAEGGVAVSDVGESEE----- 947
E + H + LR + T E+ A S +GE E
Sbjct: 1598 ELLLQTQQRRHRLRGLRNLSAFSERTLGLGPLSFTLEDEPALSTALGSQLGEEAEGEEFC 1657
Query: 948 --EASIDLEDTGPMEDTASK-------REDGSEEAILG---GEEPAKERKEVMRTETRLS 995
EA + + PM A+ +E + IL GE E EV +T
Sbjct: 1658 PCEACVR-KKVSPMSPKATMGATRGPIKEAFDLQQILQRKRGEHTDGEAAEVAPGKTHTD 1716
Query: 996 PFT-----------GEAEASRMQVSEGSPEEGS--LAKEAFLCKEDVEGEEMVTEAEANR 1042
P + G + V EG EGS L ++ + EG+ M E E
Sbjct: 1717 PTSTRTVQGAEGGLGPGLSQGPGVDEGEDGEGSQRLNRDKDPKLGEAEGDAMAQEREGKT 1776
Query: 1043 EDDRKEILPKELDLARERRK--AERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKA 1100
+ EL A + + +ER +T + + E A A D+D + +
Sbjct: 1777 HNSETSA-GSELGEAEQEGEGISERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGI 1835
Query: 1101 EEGETETEVRAEEETKAPPNEMGS--DAENEAPVEASELSDNPGLLGEDSLKETVVPIFE 1158
E E E E + E E P G +AE EA E+ ++ + P GE + V E
Sbjct: 1836 EAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDV-EAPEAEGEAQPESEDVETPE 1894
Query: 1159 ATPGFEKSLENITA--LRKEGGGERLS-EARDTEHKDREELSSRENRALKEGHRQDGEGA 1215
A + E A KE E S EA +TE +D E E + +E
Sbjct: 1895 AEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEE--------- 1945
Query: 1216 LAAPEAEPAGKVQAPEGLIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVA 1275
AA EAE G+ Q PE + + +AEE A + + LE V + TQEA
Sbjct: 1946 -AAQEAE--GQTQ-PESEVIESQEAEEEAQPESEDVEALE----------VEVETQEAEG 1991
Query: 1276 EEDPIMAEKFREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGG 1335
E P + EA E E EE+ + + Q + SEG+ E EG TQK EG
Sbjct: 1992 EAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPK-SEGEEAQEVEGETQKTEGDAQP 2050
Query: 1336 RVVAVEVLHGGGETAETAAEEREVLAGSETAEEKTIANKASSFSDVAEEETWHQQDELVG 1395
VE E E E +E + E A +A + E + E G
Sbjct: 2051 ESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAE--GEAQPESEGVEAPEAEG 2108
Query: 1396 KTAAAGKVVVEELARSGEEVPAAEEMTVTYTT-EAGVGTPGALERKTSGLGQEQEEGSEG 1454
+ A + E GE P +E + EA + G + G Q + EG E
Sbjct: 2109 EAQKAEGIEAPE--TEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEA 2166
Query: 1455 QEAATGSG------DGRQETGAAEKFRLGL-SREGERELSP-----ESLQAMATLPVKPD 1502
QEA + + + G A+ G+ + E E E P E+ +A +P+
Sbjct: 2167 QEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPE 2226
Query: 1503 FTETREKQ-QHMVQGESETADVSPNNMQV 1530
ET E + + + E ET + QV
Sbjct: 2227 GVETPEAEGEAQPESEGETQGEKKGSPQV 2255
Score = 73.6 bits (179), Expect = 1e-12
Identities = 154/704 (21%), Positives = 253/704 (35%), Gaps = 138/704 (19%)
Query: 419 EKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVTAVEEMTSK 478
+K +L +AEG + +E KT S + E L E E ++ +
Sbjct: 1755 DKDPKLGEAEGDAMAQE----------REGKTHNSETSAGSE----LGEAEQEGEGISER 1800
Query: 479 GKPGQEVL--EDDQENTLKYEYEEDFEVDEEKQGEKSNE-EGQADVQMNGIPQSPLDDKK 535
G+ G + ED+ + ++D + +G ++ E EG+A + G+ +
Sbjct: 1801 GETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDA 1860
Query: 536 DNLDPEKESETSSQKAPDARDNVKDENDGCS----------ESELEEDKQDMKTASSTSS 585
+ E + E+ +AP+A + E++ ESE E + K A +
Sbjct: 1861 QEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETE 1920
Query: 586 RSHPYSSDSEDESAVGDREA--------HTDSSTDESARRSSSQELSENDKPRKSHLPIE 637
++ EDE EA + T + SQE E +P +
Sbjct: 1921 SVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDV--- 1977
Query: 638 ESLEIEIEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEK 697
E+LE+E+E QE E + P E E EG + +E E E G + +
Sbjct: 1978 EALEVEVETQE-----AEGEAQPESEDVEAPEAEGEMQEAEE--EAQPESDGVEAQPKSE 2030
Query: 698 EKDKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNK 757
++ ++ E+ D + G+E A + +
Sbjct: 2031 GEEAQEVEGETQKTEGDAQPESDGVE----------------------------APEAEE 2062
Query: 758 ESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTA- 816
E+Q+ E +EA E + P+ D D + +GEA E EA A K
Sbjct: 2063 EAQEAEG-----EVQEA-EGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGI 2116
Query: 817 EQPELAEEFTEKREIPPGIERGAEGAAEAEGVR-RLGEGGSDPIGQA---------AAKD 866
E PE E + E E E E+EGV + EG + P + A +
Sbjct: 2117 EAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPE 2176
Query: 867 AVGLSKDEAPEKQALMLTVLETDKAASEGEQGLE--KAVLANEAAALNLEHLHEVAALRE 924
G+ EA + +E +A E + LE +A A E A E + A E
Sbjct: 2177 LEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGE 2236
Query: 925 AATSEEGEAEG------GVAVSDVGESEE--EASIDLED--------------------- 955
A EGE +G V++ D G+SEE E+S + +
Sbjct: 2237 AQPESEGETQGEKKGSPQVSLGD-GQSEEASESSSPVPEDRPTPPPSPGGDTPHQRPGSQ 2295
Query: 956 TGPMEDTASK-----REDGSEEAILGGEEPAKERK----EVMRTETRLSPFTGEAEASRM 1006
TGP AS ++D + +LG + R TR+ P + +E
Sbjct: 2296 TGPSSSRASSWGNCWQKDSENDHVLGDTRSPDAKSTGTPHAERKATRMYPESSTSEQEEA 2355
Query: 1007 QVSEGSPEEGSLAKEAFLCKED-----VEGEEMVTEAEANREDD 1045
+ +PE+G A E + +ED + E V A+ +DD
Sbjct: 2356 PLGSRTPEQG--ASEGYDLQEDQALGSLAPTEAVGRADGFGQDD 2397
Score = 63.5 bits (153), Expect = 1e-09
Identities = 174/885 (19%), Positives = 313/885 (35%), Gaps = 132/885 (14%)
Query: 399 IAMGLDKKPSLPKSRKEKSTEK--GEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKF 456
++ L+ +P+L + + E+ GEE E VRK+ + PK + + + F
Sbjct: 1629 LSFTLEDEPALSTALGSQLGEEAEGEEFCPCEACVRKKVSPMSPKAT-MGATRGPIKEAF 1687
Query: 457 SAQEIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEE 516
Q+I + T E ++ PG+ + T++ + G E+
Sbjct: 1688 DLQQILQRKRGEHTDGE--AAEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGED 1745
Query: 517 GQADVQMNGIPQSPLDDKK-DNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQ 575
G+ ++N L + + D + E+E +T + + + G E E++ +
Sbjct: 1746 GEGSQRLNRDKDPKLGEAEGDAMAQEREGKTHNSET----------SAGSELGEAEQEGE 1795
Query: 576 DMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLP 635
+ T + + + + E+A G D+ +S E E + P
Sbjct: 1796 GISERGETGGQGSGHEDNLQGEAAAGG---------DQDPGQSDGAEGIEAPEAEGEAQP 1846
Query: 636 IEESLEIEIEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAE 695
E +E + + +A+ E +P D E E AEG ++ + V
Sbjct: 1847 ESEGVEAPEAEGDAQEAEGEAQPESEDV-------EAPE------AEGEAQPESEDVETP 1893
Query: 696 EKEKDKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINS 755
E E WE Q + + A P E K++ P + A+ +
Sbjct: 1894 EAE------WE---VQPESEGAEAP---EAEKEAQP--------------ETESVEALET 1927
Query: 756 NKESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPT 815
E + + E +EA +E E ++++++ + A EA +P
Sbjct: 1928 EGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQE---------AEEEA-----QPE 1973
Query: 816 AEQPELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKD-E 874
+E E E E +E AEG A+ E S+D E
Sbjct: 1974 SEDVEALEVEVETQE--------AEGEAQPE------------------------SEDVE 2001
Query: 875 APEKQALMLTVLETDKAASEGEQGLEKAV--LANEAAALNLEHLHEVAALREAATSEEGE 932
APE + M E + S+G + K+ A E + + + + E E
Sbjct: 2002 APEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAE 2061
Query: 933 AEGGVAVSDVGESEEEASIDLEDTGPME--DTASKREDGSEEAILGGEEPAKERKEVMRT 990
E A +V E+E EA + ED E A +G E GE E E T
Sbjct: 2062 EEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPET 2121
Query: 991 ETRLSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEIL 1050
E P E+E +EG + S EA + + + E EA+ E+ + E+
Sbjct: 2122 EGEAQP---ESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPEL- 2177
Query: 1051 PKELDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLK--AEEGETETE 1108
+ ++ +A+ + ++E E ++ +A +E Q E E E E
Sbjct: 2178 -EGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGE 2236
Query: 1109 VRAEEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLE 1168
+ E E + + GS + ++ E S++ + ED P + S
Sbjct: 2237 AQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVPEDRPTPPPSPGGDTPHQRPGSQT 2296
Query: 1169 NITALRKEGGGERLSEARDTEH-----KDREELSSRENRALKEGHRQDGEGALAAPEAEP 1223
++ R G + + +H + + S+ A ++ R E + + E P
Sbjct: 2297 GPSSSRASSWGNCWQKDSENDHVLGDTRSPDAKSTGTPHAERKATRMYPESSTSEQEEAP 2356
Query: 1224 AGKVQAPEGLIPATGQAEELAAKDHDSCAGLE--GRAEGQGGVDV 1266
G +G E+ A S A E GRA+G G D+
Sbjct: 2357 LGSRTPEQGASEGYDLQEDQAL---GSLAPTEAVGRADGFGQDDL 2398
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 103 bits (256), Expect = 2e-21
Identities = 154/624 (24%), Positives = 240/624 (38%), Gaps = 76/624 (12%)
Query: 877 EKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEG- 935
EK + V + K + GE + A+ N+ + + E++ ++E ++ ++G
Sbjct: 512 EKSLKLSPVQKQKKQQTIGELTQDTALTENDDS----DEYEEMSEMKEGKACKQHVSQGI 567
Query: 936 ---GVAVSDVGESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKE---RKEVMR 989
A + S+EE I E G + SK E+ + EE K RKE +
Sbjct: 568 FMTQPATTIEAFSDEEVEIPEEKEGAED---SKGNGIEEQEVEANEENVKVHGGRKE--K 622
Query: 990 TETRLSPFTGEAEASRMQV-SEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKE 1048
TE T +AE S + S G E+G + C+E G E + E RE K+
Sbjct: 623 TEILSDDLTDKAEVSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEE--REKGEKD 680
Query: 1049 ILPKELDLARERRKAERPKTSLRKTDSE------REEVTRANALKDEDAFKEEQKLKAEE 1102
E++ E K K +K D E RE+ + ++ + EE+ + EE
Sbjct: 681 KGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEE 740
Query: 1103 GETETEVRAEEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPG 1162
E + E E+E + G + E E E E E+ +E + G
Sbjct: 741 EEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEG----DQGEG 796
Query: 1163 FEKSLENITALRKEGG---GERLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAP 1219
E+ E ++EGG G + E + ++ EE E EG ++GEG
Sbjct: 797 EEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEG--EGEEEEGEGE--EE 852
Query: 1220 EAEPAGKVQAPEGLIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAE-ED 1278
E E G+ + EG G+ E ++ + E EG+G +E E E+
Sbjct: 853 EGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEG------EEEEGEGEGEE 906
Query: 1279 PIMAEKFREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGD---MEGEGNTQKNEGMGGG 1335
E EE + EE E+ E E E + +G+G+ EGE ++ EG G G
Sbjct: 907 EGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEG 966
Query: 1336 RVVAVEVLHGGGETAETAAEEREVLAGSETAEEKTIANKASSFSDVAEEETWHQQDELVG 1395
E G GE E EE E G EE+ + + EE ++E G
Sbjct: 967 E----EEGEGEGEEGEGEGEEEE---GEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEG 1019
Query: 1396 KTAAAGKVVVEELARSGEEVPAAEEMTVTYTTEAGVGTPGALERKTSGLGQE------QE 1449
+ G+V EE GEE EE ER+ G G+E +E
Sbjct: 1020 EVE--GEVEGEEGEGEGEEEEGEEE---------------GEEREKEGEGEENRRNREEE 1062
Query: 1450 EGSEGQEAATGSGDGRQETGAAEK 1473
E EG+ TG + ++ G K
Sbjct: 1063 EEEEGKYQETGEEENERQDGEEYK 1086
Score = 83.2 bits (204), Expect = 2e-15
Identities = 155/637 (24%), Positives = 240/637 (37%), Gaps = 59/637 (9%)
Query: 735 VLALGAPTMNFMVDETAAINSNKESQQL--VQKTYTLEKKEAMEEDEA-PQHRDADIVQG 791
V +LG T + ++NSN++S +L VQK + + +D A ++ D+D +
Sbjct: 490 VESLGETTDILNMTHIMSLNSNEKSLKLSPVQKQKKQQTIGELTQDTALTENDDSDEYEE 549
Query: 792 KGEAALWGEAGAVHEAP-LRAWKPTAEQPELAEEFTEKREIPPGIERGAEGAAEAEGVRR 850
E G+A H + + +P ++E E E G E E + V
Sbjct: 550 MSEMKE-GKACKQHVSQGIFMTQPATTIEAFSDEEVEIPEEKEGAEDSKGNGIEEQEVEA 608
Query: 851 LGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANEAAA 910
E G+ K+ + D+ +K + ++ A +G +G E +
Sbjct: 609 NEENVKVHGGR---KEKTEILSDDLTDKAEVSEGKAKSVGEAEDGPEGRGDGTC--EEGS 663
Query: 911 LNLEHLHEVAALREAATSEEGEAE---GGVAVSDVGESEEEASIDLEDTGPMEDTASKRE 967
EH + RE ++G E G ++ E EE D E+ E ++
Sbjct: 664 SGAEHWQDEE--REKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQK 721
Query: 968 DGSEEAILGGEEP--AKERKEVMRTETRLSPFTGEAEASRMQVS-EGSPEEGSLAKEAFL 1024
+ ++E GGEE E +E R E G+ E +V E EEG KE
Sbjct: 722 ERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERA 781
Query: 1025 CKEDV--------EGEEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSE 1076
KE+ EGEE TE +++ E+ E++ + R+ E + + + E
Sbjct: 782 GKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGE 841
Query: 1077 REEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEASE 1136
EE ++E K E++ + EGE E E E E + E + E E E E
Sbjct: 842 GEE-EEGEGEEEEGEGKGEEEGEEGEGEEEGE---EGEGEGEEEEGEGEGEEEGEGEGEE 897
Query: 1137 LSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGERLSEARDTEHKDREEL 1196
GE +E E G K E +EG GE E + E +D E
Sbjct: 898 EE------GEGEGEEEGEGEGEEEEGEGKGEEE----GEEGEGEGEEEEGEGEGEDGEG- 946
Query: 1197 SSRENRALKEGHRQDGEGALAAPEAEPAGKVQAPEGLIPATGQAEELAAKDHDSCAGLEG 1256
E EG ++GEG E E G+ + EG G+ EE + + EG
Sbjct: 947 EGEEEEGEWEGEEEEGEG-----EGEEEGEGEGEEG--EGEGEEEEGEGEGEEEEGEEEG 999
Query: 1257 RAEGQG-----GVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEEEDKECTLETEAMQD 1311
EG+G G E E + E EE E+ EE +KE E
Sbjct: 1000 EEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENR--- 1056
Query: 1312 RNSEGDGDMEG---EGNTQKNEGMGGGRVVAVEVLHG 1345
RN E + + EG E ++NE G V + G
Sbjct: 1057 RNREEEEEEEGKYQETGEEENERQDGEEYKKVSKIKG 1093
Score = 80.9 bits (198), Expect = 9e-15
Identities = 168/701 (23%), Positives = 259/701 (36%), Gaps = 130/701 (18%)
Query: 491 ENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPLDDKKDNLDPEKESETSSQK 550
EN EYEE E+ E K ++ +G Q P + D E E +
Sbjct: 540 ENDDSDEYEEMSEMKEGKACKQHVSQGIFMTQ-------PATTIEAFSDEEVEIPEEKEG 592
Query: 551 APDARDNVKDENDGCSESELEEDKQDMKTASSTSSRSHPYSSDSEDES--------AVGD 602
A D++ N G E E+E +++++K ++ S D D++ +VG+
Sbjct: 593 AEDSKGN------GIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKAKSVGE 646
Query: 603 REAHTDSSTDESARRSSS---------QELSENDKPR-KSHLPIEESLEIEIEDQEITKA 652
E + D + SS +E E DK R + P E E+ E +E K
Sbjct: 647 AEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELA-EKEEWKKR 705
Query: 653 DVETKPMPIDESFENVLKEGTEKG-TQEIAEGLSEKSGKHVSAEEKEKDKSKLWEESTAQ 711
D E E + ++G +K QE+ EG E+ G+ EE+E D+ +
Sbjct: 706 DGE-------EQEQKEREQGHQKERNQEMEEGGEEEHGE---GEEEEGDREE-------- 747
Query: 712 VKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQKTYTLEK 771
+++K G G EEG E + +E ++ +K
Sbjct: 748 -EEEKEG-EGKEEG-----------------------EGEEVEGEREKEEGERKKEERAG 782
Query: 772 KEAMEEDEAPQHR-DADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEFTEKRE 830
KE E+E Q + + +G+GE E G V + K E+ E EE + E
Sbjct: 783 KEEKGEEEGDQGEGEEEETEGRGEEK--EEGGEVEGGEVEEGKGEREEEE--EEGEGEEE 838
Query: 831 IPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDK 890
G E EG E EG + E G + G+ ++ G ++E E + E ++
Sbjct: 839 EGEGEEEEGEGEEE-EGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEE 897
Query: 891 AASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSD-VGESEEEA 949
EGE G E+ E EEGE +G + GE EEE
Sbjct: 898 EEGEGE-GEEEGEGEGE--------------------EEEGEGKGEEEGEEGEGEGEEEE 936
Query: 950 SIDLEDTGPMEDTASKRE----------DGSEEAILGGEEPAKERKEVM---RTETRLSP 996
+ G E + E +G EE GEE E +E E
Sbjct: 937 GEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGE 996
Query: 997 FTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDL 1056
GE E + EG EE +E + +VEGEE E E ++ E KE +
Sbjct: 997 EEGEEEGEGEEEGEGEGEE----EEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEG 1052
Query: 1057 ARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETK 1116
RR E + K EE N +D + +K+ K+K G + + K
Sbjct: 1053 EENRRNREEEEEEEGKYQETGEE---ENERQDGEEYKKVSKIK---GSVKYGKHKTYQKK 1106
Query: 1117 APPNEMGSDAE--NEAPVEASELSDNPGLLGEDSLKETVVP 1155
+ N G+ E ++ PV++ L N G G V+P
Sbjct: 1107 SVTNTQGNGKEQRSKMPVQSKRLLKN-GPSGSKKFWNNVLP 1146
Score = 78.2 bits (191), Expect = 6e-14
Identities = 118/477 (24%), Positives = 182/477 (38%), Gaps = 96/477 (20%)
Query: 1014 EEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKT 1073
EE S KE CK+ V +T+ E E E+++ E+ AE K
Sbjct: 548 EEMSEMKEGKACKQHVSQGIFMTQPATTIEAFSDE----EVEIPEEKEGAEDSK------ 597
Query: 1074 DSEREEVTRANALKDEDAFKEEQKLKAEEGETE-TEVRAEEET-KAPPNEMGSDAENEAP 1131
N +++++ E+ +K G E TE+ +++ T KA +E + + EA
Sbjct: 598 ---------GNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKAKSVGEA- 647
Query: 1132 VEASELSDNPGLLGEDSLKETVVPIFEATPGFE--KSLENITALRKEGGGERLSEAR-DT 1188
D P G+ + +E + G E + E + +G GE +
Sbjct: 648 ------EDGPEGRGDGTCEE-------GSSGAEHWQDEEREKGEKDKGRGEMERPGEGEK 694
Query: 1189 EHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKVQAPEGLIPATGQAEELAAKDH 1248
E ++EE R+ ++ R+ G E E G+ + EG + EE ++
Sbjct: 695 ELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEG------EEEEGDREEE 748
Query: 1249 DSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEEEDKECTLETEA 1308
+ G EG+ EG+G EE E E+E+ E E A
Sbjct: 749 EEKEG-EGKEEGEG------------------------EEV--EGEREKEEGERKKEERA 781
Query: 1309 MQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEEREVLAGSETAEE 1368
++ E +GD +GEG ++ EG G + EV GGE E E E E EE
Sbjct: 782 GKEEKGEEEGD-QGEGEEEETEGRGEEKEEGGEV--EGGEVEEGKGEREEEEEEGEGEEE 838
Query: 1369 KTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEELARSGEEVPAAEEMTVTYTTE 1428
+ + EEE +++E GK EE GE EE E
Sbjct: 839 E---------GEGEEEEGEGEEEEGEGKG--------EEEGEEGEGEEEGEEGEGEGEEE 881
Query: 1429 AGVGTPGALERKTSGLGQEQEEGSEGQEAATGSGDGRQETGAAEKFRLGLSREGERE 1485
G G E + G G+ +EE EG+ G G+G +E G + G EGE E
Sbjct: 882 EGEG-----EGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGE 933
Score = 72.8 bits (177), Expect = 2e-12
Identities = 132/636 (20%), Positives = 222/636 (34%), Gaps = 138/636 (21%)
Query: 404 DKKPSLPKSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKT 463
D++ +P+ ++ KG +++ E + +E V R E KT + + + T
Sbjct: 581 DEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKE----KTEILS-----DDLT 631
Query: 464 GLKEVVTAVEEMTSKGKPGQEVLEDD--QENTLKYEYEEDFEVDEEKQGEKSNEEGQADV 521
EV + + + G E D +E + E+ +D +E ++GEK ++G+ ++
Sbjct: 632 DKAEVSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQD---EEREKGEK--DKGRGEM 686
Query: 522 QMNGIPQSPLDDKKD--NLDPEKESETSSQKAPDARDNVKDENDGCSE-SELEEDKQDMK 578
+ G + L +K++ D E++ + ++ N + E G E E EE++ D +
Sbjct: 687 ERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDRE 746
Query: 579 TASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEE 638
+ E E G+RE E + E D+ E
Sbjct: 747 EEEEKEGEG---KEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEG 803
Query: 639 SLEIEIEDQEITKADVET-KPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEK 697
E + E E+ +VE K +E E +E +G +E EG E+ E +
Sbjct: 804 RGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGE 863
Query: 698 EKDKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNK 757
E + + EE + ++++ G EEG +
Sbjct: 864 EGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEG---------------------------- 895
Query: 758 ESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAE 817
E++E E E + + +G+G+ GE G
Sbjct: 896 ------------EEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGE------------ 931
Query: 818 QPELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPE 877
EE + E G G E E EG GEG + G+ ++ G ++E E
Sbjct: 932 ----GEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGE 987
Query: 878 KQALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGV 937
+ E ++ EGE+ E EEGE E
Sbjct: 988 GEG------EEEEGEEEGEE--------------------------EGEGEEEGEGE--- 1012
Query: 938 AVSDVGESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPF 997
GE EEE ++ E G + + E+G EE GEE KE
Sbjct: 1013 -----GEEEEEGEVEGEVEGEEGEGEGEEEEGEEE----GEEREKE-------------- 1049
Query: 998 TGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEE 1033
GE E +R E EEG + E +GEE
Sbjct: 1050 -GEGEENRRNREEEEEEEGKYQETGEEENERQDGEE 1084
Score = 35.4 bits (80), Expect = 0.43
Identities = 35/165 (21%), Positives = 69/165 (41%), Gaps = 21/165 (12%)
Query: 473 EEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPLD 532
EE +G+ +E E++ E + E E + E +EE++GE E + + G + +
Sbjct: 982 EEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEE---E 1038
Query: 533 DKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSSRSHPYSS 592
+++ + EKE E +EN E E EE+ + +T + R
Sbjct: 1039 GEEEGEEREKEGE-------------GEENRRNREEEEEEEGKYQETGEEENER-----Q 1080
Query: 593 DSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIE 637
D E+ V + ++ ++ S N K ++S +P++
Sbjct: 1081 DGEEYKKVSKIKGSVKYGKHKTYQKKSVTNTQGNGKEQRSKMPVQ 1125
Score = 33.1 bits (74), Expect = 2.1
Identities = 56/250 (22%), Positives = 93/250 (37%), Gaps = 31/250 (12%)
Query: 1280 IMAEKFREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVA 1339
IM+ E+++ P +++ K+ T+ +E D E E ++ EG + V+
Sbjct: 505 IMSLNSNEKSLKLSPVQKQKKQQTIGELTQDTALTENDDSDEYEEMSEMKEGKACKQHVS 564
Query: 1340 VEVLHGGGETAETAAEEREVLAGSETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAA 1399
+ T A + EV E EEK A + S + + E+E ++ + K
Sbjct: 565 QGIFMTQPATTIEAFSDEEV----EIPEEKEGA-EDSKGNGIEEQEVEANEENV--KVHG 617
Query: 1400 AGKVVVEELARSGEEVPAAEEMTVTYTTEAGVGT----PGALERKTSGLGQEQEEGSEGQ 1455
K E L+ + E EA G G E +SG Q+E E
Sbjct: 618 GRKEKTEILSDDLTDKAEVSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKG 677
Query: 1456 EAATG------SGDGRQETGAAEKFRLGLSREGERELSPESLQAMATLPVKPDFTETREK 1509
E G G+G +E E+++ R+GE + E Q +E+
Sbjct: 678 EKDKGRGEMERPGEGEKELAEKEEWK---KRDGEEQEQKEREQG-----------HQKER 723
Query: 1510 QQHMVQGESE 1519
Q M +G E
Sbjct: 724 NQEMEEGGEE 733
>gi|150170670 piccolo isoform 2 [Homo sapiens]
Length = 4935
Score = 87.0 bits (214), Expect = 1e-16
Identities = 170/833 (20%), Positives = 323/833 (38%), Gaps = 123/833 (14%)
Query: 405 KKPSLPKSRKEKSTEK-----GEELKKAEGKVRKEREYVIPKRNEIKENKTSV--SAKFS 457
+K L K ++ S EK + K+ E K+ K++ + ++ + E K + K
Sbjct: 1169 EKVILEKVKETLSMEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPEEEKIR 1228
Query: 458 AQEIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEG 517
++E K L+E E+ + E+ + + LK + + E E + K+ +EG
Sbjct: 1229 SEEKKPLLEEKKPTPEDKKLLPEAKTSAPEEQKHDLLKSQVQIAEEKLEGRVAPKTVQEG 1288
Query: 518 -QADVQMNGIP----------------------QSPLDDKKDNLDPEKE--------SET 546
Q +M G+P Q P K D ++P KE S+T
Sbjct: 1289 KQPQTKMEGLPSGTPQSLPKEDDKTTKTIKEQPQPPCTAKPDQVEPGKEKTEKEDDKSDT 1348
Query: 547 SSQKAPDARDNVKD---ENDGCSESELE-------EDKQDMK-----TASSTSSRSHPYS 591
SS + P + + D +DG S S E ++K +K + S SS S P
Sbjct: 1349 SSSQQPKSPQGLSDTGYSSDGISSSLGEIPSLIPTDEKDILKGLKKDSFSQESSPSSPSD 1408
Query: 592 SDSEDESAVGDREAHTDSSTDE-SARRSSSQELS-ENDKPRKSHLPIEESLEIEIEDQEI 649
+ + + EA + DE S +++ E+S E K ++ + E+LEI I ++EI
Sbjct: 1409 LAKLESTVLSILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKTQSLSETLEITISEEEI 1468
Query: 650 TKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEE----------KEK 699
++ E K +S +++ K E + ++ + + S EE + K
Sbjct: 1469 KESQEERKDTFKKDSQQDIPSSKDHKEKSEFVDDITTRREPYDSVEESSESENSPVPQRK 1528
Query: 700 DKSKLWEESTAQVKDKKAGLPGLEEG--GKDSLPL-AYVLALGAPTMNFMVDETAAINSN 756
++ + S+ + K + + G EE K + + A A G+ F+ ++ I+S+
Sbjct: 1529 RRTSVGSSSSDEYKQEDSQGSGEEEDFIRKQIIEMSADEDASGSEDDEFIRNQLKEISSS 1588
Query: 757 KESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTA 816
ESQ+ E+ + + A +HR + K ++ +AG H +
Sbjct: 1589 TESQK-------KEETKGKGKITAGKHRR---LTRKSSTSIDEDAGRRHSWHDEDDEAFD 1638
Query: 817 EQPELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAP 876
E PEL T+ +E + G G + + L +D +++ L DE P
Sbjct: 1639 ESPELKYRETKSQESEELVVTGGGGLRRFKTI-ELNSTIADKYSAESSQKKTSLYFDEEP 1697
Query: 877 EKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGG 936
E + LT D++ EG L + + + V++L E + S +
Sbjct: 1698 ELEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTS------VSSLDEDSDSSPSHKK-- 1749
Query: 937 VAVSDVGESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSP 996
GES+++ GP+ T ED SE EE +E +E+++ + +
Sbjct: 1750 ------GESKQQRKARHRPHGPLLPTI---EDSSE------EEELREEEELLKEQEKQRE 1794
Query: 997 FTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDL 1056
+ S + S+ +E + K + +A E L + ++
Sbjct: 1795 IEQQQRKSSSKKSKKDKDELRAQRRRERPKTPPSNLSPIEDASPTEE------LRQAAEM 1848
Query: 1057 ARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFK-----------EEQKLKAEEGET 1105
R + + ++D E E++ ++ + +K +EQ + +EG
Sbjct: 1849 EELHRSSCSEYSPSIESDPEGFEISPEKIIEVQKVYKLPTAVSLYSPTDEQSIMQKEGSQ 1908
Query: 1106 ETEVRAEEETKAPPNEMGSDAENEAPVEASELSDNP----GLLGEDSLKETVV 1154
+ AEE + ++ A E E+ + G+L ED + E++V
Sbjct: 1909 KALKSAEEMYEEMMHKTHKYKAFPAANERDEVFEKEPLYGGMLIEDYIYESLV 1961
Score = 62.0 bits (149), Expect = 4e-09
Identities = 159/817 (19%), Positives = 312/817 (38%), Gaps = 124/817 (15%)
Query: 429 GKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVTAVEEMTSKGKP-GQEVLE 487
G +RK + P + K + V + S+Q KT + V V++ + K ++V+
Sbjct: 1120 GDIRK----MPPAPSGPKASPMPVPTESSSQ--KTAVPPQVKLVKKQEQEVKTEAEKVIL 1173
Query: 488 DDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPLDDKKDNLDPEKESETS 547
+ + TL E ++KQ E E+ +A + PL ++K L PE+E S
Sbjct: 1174 EKVKETLSMEKIPPMVTTDQKQEESKLEKDKASALQE---KKPLPEEK-KLIPEEEKIRS 1229
Query: 548 SQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHT 607
+K P + + EDK+ + A +++ + ++
Sbjct: 1230 EEKKPLLEE----------KKPTPEDKKLLPEAKTSAPEEQKHDL----------LKSQV 1269
Query: 608 DSSTDESARRSSSQELSENDKP--RKSHLPIEESLEIEIEDQEITKADVETKPMPIDESF 665
+ ++ R + + + E +P + LP + ED + TK ++ +P P +
Sbjct: 1270 QIAEEKLEGRVAPKTVQEGKQPQTKMEGLPSGTPQSLPKEDDKTTKT-IKEQPQPPCTAK 1328
Query: 666 ENVLKEGTEKGTQE-----IAEGLSEKSGKHVSAEEKEKD--KSKLWEESTAQVKDKKAG 718
+ ++ G EK +E + KS + +S D S L E + D+K
Sbjct: 1329 PDQVEPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSLGEIPSLIPTDEKDI 1388
Query: 719 LPGLEEGG--KDSLPLAYV-LALGAPTMNFMVDETAAINSNKESQQLVQ-------KTYT 768
L GL++ ++S P + LA T+ +++ A+ ++++S++ Q +
Sbjct: 1389 LKGLKKDSFSQESSPSSPSDLAKLESTVLSILEAQASTLADEKSEKKTQPHEVSPEQPKD 1448
Query: 769 LEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEFTEK 828
EK +++ E + +I + + E + + + P + K E+ E ++ T +
Sbjct: 1449 QEKTQSLSETLEITISEEEIKESQEERKDTFKKDSQQDIP--SSKDHKEKSEFVDDITTR 1506
Query: 829 REIPPGIERGAEGAAEAEGVRR----LGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLT 884
RE +E +E R+ +G SD Q +D+ G ++E ++ ++
Sbjct: 1507 REPYDSVEESSESENSPVPQRKRRTSVGSSSSDEYKQ---EDSQGSGEEEDFIRKQIIEM 1563
Query: 885 VLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGE 944
+ D + SE ++ + L E+++ E+ EE + +G +
Sbjct: 1564 SADEDASGSEDDEFIRN-------------QLKEISSSTESQKKEETKGKGKITAGKHRR 1610
Query: 945 SEEEASIDLE-----------------DTGPMEDTASKREDGSEEAILGGEEPAKERKEV 987
++S ++ D P + SEE ++ G + K +
Sbjct: 1611 LTRKSSTSIDEDAGRRHSWHDEDDEAFDESPELKYRETKSQESEELVVTGGGGLRRFKTI 1670
Query: 988 MRTETRLSPFTGEAEASR------------MQVSEGSPEEGSLAK-EAFLCKEDVEGEEM 1034
T ++ E+ + M+ SPE+ S + + L
Sbjct: 1671 ELNSTIADKYSAESSQKKTSLYFDEEPELEMESLTDSPEDRSRGEGSSSLHASSFTPGTS 1730
Query: 1035 VTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKT--DSEREEVTRANALKDEDAF 1092
T + ED K+ + ++R+ RP L T DS EE R ++E+
Sbjct: 1731 PTSVSSLDEDSDSSPSHKKGESKQQRKARHRPHGPLLPTIEDSSEEEELR----EEEELL 1786
Query: 1093 KEEQKLKAEEGET-----------ETEVRAE---EETKAPPNEMGSDAENEAPVEASELS 1138
KE++K + E + + E+RA+ E K PP+ + S E+ +P E +
Sbjct: 1787 KEQEKQREIEQQQRKSSSKKSKKDKDELRAQRRRERPKTPPSNL-SPIEDASPTEELRQA 1845
Query: 1139 DNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRK 1175
L S E I GFE S E I ++K
Sbjct: 1846 AEMEELHRSSCSEYSPSIESDPEGFEISPEKIIEVQK 1882
Score = 35.0 bits (79), Expect = 0.56
Identities = 92/551 (16%), Positives = 198/551 (35%), Gaps = 89/551 (16%)
Query: 873 DEAPEKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGE 932
+ + +K A+ V K E + EK +L L++E + + + + E
Sbjct: 1142 ESSSQKTAVPPQVKLVKKQEQEVKTEAEKVILEKVKETLSMEKIPPMVTTDQKQEESKLE 1201
Query: 933 AEGGVAVSDVGESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTET 992
+ A+ + EE + E+ K ++ +L ++P E K+++
Sbjct: 1202 KDKASALQEKKPLPEEKKLIPEE--------EKIRSEEKKPLLEEKKPTPEDKKLLPEAK 1253
Query: 993 RLSPFTGEAEASRMQVSEGSPE-EGSLA----KEAFLCKEDVEGEEMVTEAEANREDDRK 1047
+P + + + QV + EG +A +E + +EG T +EDD+
Sbjct: 1254 TSAPEEQKHDLLKSQVQIAEEKLEGRVAPKTVQEGKQPQTKMEGLPSGTPQSLPKEDDKT 1313
Query: 1048 EILPKELDLARERRKAERPKTSLRKTDSEREEVTRANALKDE------DAFKEEQKLKAE 1101
KE K ++ + KT+ E ++ +++ + + D + +
Sbjct: 1314 TKTIKEQPQPPCTAKPDQVEPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSS 1373
Query: 1102 EGETETEVRAEEETKAPPNEMGSDAENEAPVEASELSD-----------NPGLLGEDSLK 1150
GE + + +E+ + S ++ +P S+L+ L ++ +
Sbjct: 1374 LGEIPSLIPTDEKDILKGLKKDSFSQESSPSSPSDLAKLESTVLSILEAQASTLADEKSE 1433
Query: 1151 ETVVPIFEATPGFEKSLENITALRKEG----GGERLSEARDTEHKDREELSSRENRALKE 1206
+ P E +P K E +L + E + E+++ E KD + S+++ +
Sbjct: 1434 KKTQP-HEVSPEQPKDQEKTQSLSETLEITISEEEIKESQE-ERKDTFKKDSQQDIPSSK 1491
Query: 1207 GHRQDGEGAL-AAPEAEPAGKVQ----APEGLIPATGQAEELAAKDHDSCAGLEGRAEGQ 1261
H++ E EP V+ + +P + + + D + + G
Sbjct: 1492 DHKEKSEFVDDITTRREPYDSVEESSESENSPVPQRKRRTSVGSSSSDEYKQEDSQGSG- 1550
Query: 1262 GGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGDME 1321
EE+ + ++ E + DED ED E ++++ E E
Sbjct: 1551 --------------EEEDFIRKQIIEMSADEDASGSED------DEFIRNQLKEISSSTE 1590
Query: 1322 GEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEEREVLAGSETAEEKTIANKASSFSDV 1381
+ +K E G G++ TA + R + S T+ ++ D
Sbjct: 1591 SQ---KKEETKGKGKI--------------TAGKHRRLTRKSSTSIDE----------DA 1623
Query: 1382 AEEETWHQQDE 1392
+WH +D+
Sbjct: 1624 GRRHSWHDEDD 1634
>gi|150378539 piccolo isoform 1 [Homo sapiens]
Length = 5142
Score = 87.0 bits (214), Expect = 1e-16
Identities = 170/833 (20%), Positives = 323/833 (38%), Gaps = 123/833 (14%)
Query: 405 KKPSLPKSRKEKSTEK-----GEELKKAEGKVRKEREYVIPKRNEIKENKTSV--SAKFS 457
+K L K ++ S EK + K+ E K+ K++ + ++ + E K + K
Sbjct: 1169 EKVILEKVKETLSMEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPEEEKIR 1228
Query: 458 AQEIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEG 517
++E K L+E E+ + E+ + + LK + + E E + K+ +EG
Sbjct: 1229 SEEKKPLLEEKKPTPEDKKLLPEAKTSAPEEQKHDLLKSQVQIAEEKLEGRVAPKTVQEG 1288
Query: 518 -QADVQMNGIP----------------------QSPLDDKKDNLDPEKE--------SET 546
Q +M G+P Q P K D ++P KE S+T
Sbjct: 1289 KQPQTKMEGLPSGTPQSLPKEDDKTTKTIKEQPQPPCTAKPDQVEPGKEKTEKEDDKSDT 1348
Query: 547 SSQKAPDARDNVKD---ENDGCSESELE-------EDKQDMK-----TASSTSSRSHPYS 591
SS + P + + D +DG S S E ++K +K + S SS S P
Sbjct: 1349 SSSQQPKSPQGLSDTGYSSDGISSSLGEIPSLIPTDEKDILKGLKKDSFSQESSPSSPSD 1408
Query: 592 SDSEDESAVGDREAHTDSSTDE-SARRSSSQELS-ENDKPRKSHLPIEESLEIEIEDQEI 649
+ + + EA + DE S +++ E+S E K ++ + E+LEI I ++EI
Sbjct: 1409 LAKLESTVLSILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKTQSLSETLEITISEEEI 1468
Query: 650 TKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEE----------KEK 699
++ E K +S +++ K E + ++ + + S EE + K
Sbjct: 1469 KESQEERKDTFKKDSQQDIPSSKDHKEKSEFVDDITTRREPYDSVEESSESENSPVPQRK 1528
Query: 700 DKSKLWEESTAQVKDKKAGLPGLEEG--GKDSLPL-AYVLALGAPTMNFMVDETAAINSN 756
++ + S+ + K + + G EE K + + A A G+ F+ ++ I+S+
Sbjct: 1529 RRTSVGSSSSDEYKQEDSQGSGEEEDFIRKQIIEMSADEDASGSEDDEFIRNQLKEISSS 1588
Query: 757 KESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTA 816
ESQ+ E+ + + A +HR + K ++ +AG H +
Sbjct: 1589 TESQK-------KEETKGKGKITAGKHRR---LTRKSSTSIDEDAGRRHSWHDEDDEAFD 1638
Query: 817 EQPELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAP 876
E PEL T+ +E + G G + + L +D +++ L DE P
Sbjct: 1639 ESPELKYRETKSQESEELVVTGGGGLRRFKTI-ELNSTIADKYSAESSQKKTSLYFDEEP 1697
Query: 877 EKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGG 936
E + LT D++ EG L + + + V++L E + S +
Sbjct: 1698 ELEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTS------VSSLDEDSDSSPSHKK-- 1749
Query: 937 VAVSDVGESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSP 996
GES+++ GP+ T ED SE EE +E +E+++ + +
Sbjct: 1750 ------GESKQQRKARHRPHGPLLPTI---EDSSE------EEELREEEELLKEQEKQRE 1794
Query: 997 FTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDL 1056
+ S + S+ +E + K + +A E L + ++
Sbjct: 1795 IEQQQRKSSSKKSKKDKDELRAQRRRERPKTPPSNLSPIEDASPTEE------LRQAAEM 1848
Query: 1057 ARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFK-----------EEQKLKAEEGET 1105
R + + ++D E E++ ++ + +K +EQ + +EG
Sbjct: 1849 EELHRSSCSEYSPSIESDPEGFEISPEKIIEVQKVYKLPTAVSLYSPTDEQSIMQKEGSQ 1908
Query: 1106 ETEVRAEEETKAPPNEMGSDAENEAPVEASELSDNP----GLLGEDSLKETVV 1154
+ AEE + ++ A E E+ + G+L ED + E++V
Sbjct: 1909 KALKSAEEMYEEMMHKTHKYKAFPAANERDEVFEKEPLYGGMLIEDYIYESLV 1961
Score = 62.0 bits (149), Expect = 4e-09
Identities = 159/817 (19%), Positives = 312/817 (38%), Gaps = 124/817 (15%)
Query: 429 GKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVTAVEEMTSKGKP-GQEVLE 487
G +RK + P + K + V + S+Q KT + V V++ + K ++V+
Sbjct: 1120 GDIRK----MPPAPSGPKASPMPVPTESSSQ--KTAVPPQVKLVKKQEQEVKTEAEKVIL 1173
Query: 488 DDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPLDDKKDNLDPEKESETS 547
+ + TL E ++KQ E E+ +A + PL ++K L PE+E S
Sbjct: 1174 EKVKETLSMEKIPPMVTTDQKQEESKLEKDKASALQE---KKPLPEEK-KLIPEEEKIRS 1229
Query: 548 SQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHT 607
+K P + + EDK+ + A +++ + ++
Sbjct: 1230 EEKKPLLEE----------KKPTPEDKKLLPEAKTSAPEEQKHDL----------LKSQV 1269
Query: 608 DSSTDESARRSSSQELSENDKP--RKSHLPIEESLEIEIEDQEITKADVETKPMPIDESF 665
+ ++ R + + + E +P + LP + ED + TK ++ +P P +
Sbjct: 1270 QIAEEKLEGRVAPKTVQEGKQPQTKMEGLPSGTPQSLPKEDDKTTKT-IKEQPQPPCTAK 1328
Query: 666 ENVLKEGTEKGTQE-----IAEGLSEKSGKHVSAEEKEKD--KSKLWEESTAQVKDKKAG 718
+ ++ G EK +E + KS + +S D S L E + D+K
Sbjct: 1329 PDQVEPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSLGEIPSLIPTDEKDI 1388
Query: 719 LPGLEEGG--KDSLPLAYV-LALGAPTMNFMVDETAAINSNKESQQLVQ-------KTYT 768
L GL++ ++S P + LA T+ +++ A+ ++++S++ Q +
Sbjct: 1389 LKGLKKDSFSQESSPSSPSDLAKLESTVLSILEAQASTLADEKSEKKTQPHEVSPEQPKD 1448
Query: 769 LEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEFTEK 828
EK +++ E + +I + + E + + + P + K E+ E ++ T +
Sbjct: 1449 QEKTQSLSETLEITISEEEIKESQEERKDTFKKDSQQDIP--SSKDHKEKSEFVDDITTR 1506
Query: 829 REIPPGIERGAEGAAEAEGVRR----LGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLT 884
RE +E +E R+ +G SD Q +D+ G ++E ++ ++
Sbjct: 1507 REPYDSVEESSESENSPVPQRKRRTSVGSSSSDEYKQ---EDSQGSGEEEDFIRKQIIEM 1563
Query: 885 VLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGE 944
+ D + SE ++ + L E+++ E+ EE + +G +
Sbjct: 1564 SADEDASGSEDDEFIRN-------------QLKEISSSTESQKKEETKGKGKITAGKHRR 1610
Query: 945 SEEEASIDLE-----------------DTGPMEDTASKREDGSEEAILGGEEPAKERKEV 987
++S ++ D P + SEE ++ G + K +
Sbjct: 1611 LTRKSSTSIDEDAGRRHSWHDEDDEAFDESPELKYRETKSQESEELVVTGGGGLRRFKTI 1670
Query: 988 MRTETRLSPFTGEAEASR------------MQVSEGSPEEGSLAK-EAFLCKEDVEGEEM 1034
T ++ E+ + M+ SPE+ S + + L
Sbjct: 1671 ELNSTIADKYSAESSQKKTSLYFDEEPELEMESLTDSPEDRSRGEGSSSLHASSFTPGTS 1730
Query: 1035 VTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKT--DSEREEVTRANALKDEDAF 1092
T + ED K+ + ++R+ RP L T DS EE R ++E+
Sbjct: 1731 PTSVSSLDEDSDSSPSHKKGESKQQRKARHRPHGPLLPTIEDSSEEEELR----EEEELL 1786
Query: 1093 KEEQKLKAEEGET-----------ETEVRAE---EETKAPPNEMGSDAENEAPVEASELS 1138
KE++K + E + + E+RA+ E K PP+ + S E+ +P E +
Sbjct: 1787 KEQEKQREIEQQQRKSSSKKSKKDKDELRAQRRRERPKTPPSNL-SPIEDASPTEELRQA 1845
Query: 1139 DNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRK 1175
L S E I GFE S E I ++K
Sbjct: 1846 AEMEELHRSSCSEYSPSIESDPEGFEISPEKIIEVQK 1882
Score = 35.0 bits (79), Expect = 0.56
Identities = 92/551 (16%), Positives = 198/551 (35%), Gaps = 89/551 (16%)
Query: 873 DEAPEKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGE 932
+ + +K A+ V K E + EK +L L++E + + + + E
Sbjct: 1142 ESSSQKTAVPPQVKLVKKQEQEVKTEAEKVILEKVKETLSMEKIPPMVTTDQKQEESKLE 1201
Query: 933 AEGGVAVSDVGESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTET 992
+ A+ + EE + E+ K ++ +L ++P E K+++
Sbjct: 1202 KDKASALQEKKPLPEEKKLIPEE--------EKIRSEEKKPLLEEKKPTPEDKKLLPEAK 1253
Query: 993 RLSPFTGEAEASRMQVSEGSPE-EGSLA----KEAFLCKEDVEGEEMVTEAEANREDDRK 1047
+P + + + QV + EG +A +E + +EG T +EDD+
Sbjct: 1254 TSAPEEQKHDLLKSQVQIAEEKLEGRVAPKTVQEGKQPQTKMEGLPSGTPQSLPKEDDKT 1313
Query: 1048 EILPKELDLARERRKAERPKTSLRKTDSEREEVTRANALKDE------DAFKEEQKLKAE 1101
KE K ++ + KT+ E ++ +++ + + D + +
Sbjct: 1314 TKTIKEQPQPPCTAKPDQVEPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSS 1373
Query: 1102 EGETETEVRAEEETKAPPNEMGSDAENEAPVEASELSD-----------NPGLLGEDSLK 1150
GE + + +E+ + S ++ +P S+L+ L ++ +
Sbjct: 1374 LGEIPSLIPTDEKDILKGLKKDSFSQESSPSSPSDLAKLESTVLSILEAQASTLADEKSE 1433
Query: 1151 ETVVPIFEATPGFEKSLENITALRKEG----GGERLSEARDTEHKDREELSSRENRALKE 1206
+ P E +P K E +L + E + E+++ E KD + S+++ +
Sbjct: 1434 KKTQP-HEVSPEQPKDQEKTQSLSETLEITISEEEIKESQE-ERKDTFKKDSQQDIPSSK 1491
Query: 1207 GHRQDGEGAL-AAPEAEPAGKVQ----APEGLIPATGQAEELAAKDHDSCAGLEGRAEGQ 1261
H++ E EP V+ + +P + + + D + + G
Sbjct: 1492 DHKEKSEFVDDITTRREPYDSVEESSESENSPVPQRKRRTSVGSSSSDEYKQEDSQGSG- 1550
Query: 1262 GGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGDME 1321
EE+ + ++ E + DED ED E ++++ E E
Sbjct: 1551 --------------EEEDFIRKQIIEMSADEDASGSED------DEFIRNQLKEISSSTE 1590
Query: 1322 GEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEEREVLAGSETAEEKTIANKASSFSDV 1381
+ +K E G G++ TA + R + S T+ ++ D
Sbjct: 1591 SQ---KKEETKGKGKI--------------TAGKHRRLTRKSSTSIDE----------DA 1623
Query: 1382 AEEETWHQQDE 1392
+WH +D+
Sbjct: 1624 GRRHSWHDEDD 1634
>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
Length = 2454
Score = 83.6 bits (205), Expect = 1e-15
Identities = 151/748 (20%), Positives = 281/748 (37%), Gaps = 130/748 (17%)
Query: 419 EKGEELKKAEGKVRKEREYV-----IPKRNEIKENKTSVSAKFSAQEIKTGLKEVVTAVE 473
++ E AEG V K+ + +PK+ + + V ++ T L+ A
Sbjct: 845 QERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAET 904
Query: 474 EMTSKG------KPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIP 527
+ SK K Q+ L D E LK + ++ D++KQ +K EE
Sbjct: 905 KEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEE----------K 954
Query: 528 QSPLDDKKDNLDPEKESETSS---QKAPDARD------NVKDENDGCSESELEEDKQDMK 578
+ P D KK + E++ E+SS +K P+ + +K +G ++ E K+ K
Sbjct: 955 KKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGE----KKSKK 1010
Query: 579 TASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESA------RRSSSQELSENDKPRKS 632
TS + S +E + GD DSS D+ + R +L ++
Sbjct: 1011 IRDKTSKKKDELSDYAEKSTGKGDS---CDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQ 1067
Query: 633 HLPIEESLEIEIEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHV 692
++ + +++ +D K + + E N+ +++ T+EI G S +
Sbjct: 1068 DCSSSDTEKYSMKEDGCNSSDKRLKRIELRER-RNL---SSKRNTKEIQSGSSSSDAEES 1123
Query: 693 SAEEKEKDKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAA 752
S + K+K + ++ VK+KK +L T D T++
Sbjct: 1124 SEDNKKKKQRTSSKKKAVIVKEKKRN------------------SLRTSTKRKQADITSS 1165
Query: 753 INSNKESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAW 812
+S+ E + + ++ E + + + + + ++ G + + L
Sbjct: 1166 SSSDIED----------DDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKS 1215
Query: 813 KPTAEQPELAEEFTEKR--------EIPPGIERGAEGAAE---AEGVRRLGEGGSDPIGQ 861
P + + E R EI + +G+++ EG +R G+ + G
Sbjct: 1216 VPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGD 1275
Query: 862 AAAKDAVGLSKD---EAPEKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHE 918
AK+ V D E +K +L S+GE G EK E H
Sbjct: 1276 EEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKE-------HKEV 1328
Query: 919 VAALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKREDGSEEAILGGE 978
R +SE+ E +S+ + S E+ ED R +++A L
Sbjct: 1329 KGRNRRKVSSEDSE-----------DSDFQESGVSEEVSESEDEQRPRTRSAKKAELEEN 1377
Query: 979 EPAKERKEVMRTETRLSPFTGEAEASRMQVSEGSPEEG-SLAKEAFLCKEDVEGEEMVTE 1037
+ + ++K+ R R++V E S E S ++E KE+ E EE E
Sbjct: 1378 QRSYKQKKKRR---------------RIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEE 1422
Query: 1038 AEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQK 1097
E E+D + K R+ K ++ +T + E EE + A ++ + K +
Sbjct: 1423 EEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREKLREV 1482
Query: 1098 LKAEEGE-------TETEVRAEEETKAP 1118
++ E+ T+ + +EETK P
Sbjct: 1483 IEIEDASPTKCPITTKLVLDEDEETKEP 1510
Score = 69.3 bits (168), Expect = 3e-11
Identities = 209/1195 (17%), Positives = 443/1195 (37%), Gaps = 164/1195 (13%)
Query: 414 KEKSTEKGEELK-KAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVTAV 472
KEK+T++ + + K E K RK + ++ +I +++ +S K Q + + V
Sbjct: 387 KEKNTKEHKVIDAKFETKARKGEKPCALEKKDISKSEAKLSRK---QVDSEHMHQNVPTE 443
Query: 473 EEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPLD 532
E+ T+K G+ D +E E Q E +N D+ + +P S +
Sbjct: 444 EQRTNKSTGGEHKKSDRKE---------------EPQYEPANTSEDLDMDIVSVPSSVPE 488
Query: 533 DKKDNLDPEKESETSSQKAPDARDNV---------------KDENDGCSESELEEDKQDM 577
D +NL+ E ++S D KD G + +++
Sbjct: 489 DIFENLETAMEVQSSVDHQGDGSSGTEQEVESSSVKLNISSKDNRGGIKSKTTAKVTKEL 548
Query: 578 KTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSS-SQELSENDKPRKSHLPI 636
+ S S+ ++ + D++ + + + QE S+N+ HL +
Sbjct: 549 YVKLTPVSLSNSPIKGADCQEVPQDKDGYKSCGLNPKLEKCGLGQENSDNE-----HL-V 602
Query: 637 EESLEIEIEDQEITKAD-VETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAE 695
E + + +E+ ++ ++ V+T P+ V T +E E + EK + +S
Sbjct: 603 ENEVSLLLEESDLRRSPRVKTTPLRRPTETNPV----TSNSDEECNETVKEK--QKLSVP 656
Query: 696 EKEKDKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINS 755
++KDK + + K K E + +LA+ + E + ++
Sbjct: 657 VRKKDKRNSSDSAIDNPKPNKLPKSKQSETVDQNSDSDEMLAI--------LKEVSRMSH 708
Query: 756 NKESQQLVQKTYTLE------KKEAMEEDEAPQHR-----DADIVQGKGEAALWGEAGAV 804
+ S + + +T K +A ++D+ + R +D KG++A ++ +
Sbjct: 709 SSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSA---KSSII 765
Query: 805 HEAPLRAWKPTAE-QPELAEEF----------TEKREIP-------PGIERGAEGAAEAE 846
+ + ++ EL +E T K+ IP E+ ++ + +
Sbjct: 766 SKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHSKKGMDNQ 825
Query: 847 GVRRL---GEGGSDPIGQAAAKDAVGLSKDEAPEKQALM--LTVLETDKAASEGEQGLEK 901
G + L EG SD + ++ ++ + +M L + AS G++K
Sbjct: 826 GHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDK 885
Query: 902 AVLANEAAALNLEHLHEVAALREAATSEEGEAEGGV--AVSDVGE-------SEEEASID 952
L+ + + + +VA +E + + + V +SD+ E S+E + D
Sbjct: 886 --LSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDD 943
Query: 953 LEDTGPMEDTASKREDGSEEAILGGE--EPAKERKEVMRTETRLSPFTGEAEASRMQVSE 1010
+ + + K D ++ I + E + + E + + F + + ++
Sbjct: 944 KKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTD 1003
Query: 1011 GSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSL 1070
G + + + K+++ + + + D ++ K RE+++ + S
Sbjct: 1004 GEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSS 1063
Query: 1071 RKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEA 1130
RK T ++K++ +++LK E + ++ TK E+ S + +
Sbjct: 1064 RKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTK----EIQSGSSSSD 1119
Query: 1131 PVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGERLSEARDTEH 1190
E+SE DN S K+ V + E +R S T+
Sbjct: 1120 AEESSE--DNKKKKQRTSSKKKAVIVKEK--------------------KRNSLRTSTKR 1157
Query: 1191 KDREELSSRENRALKEGHRQDGEGALAAPEAEPAGK---VQAPEGLIPATG-----QAEE 1242
K + SS + + GEG+ + +P + + + G ++G ++
Sbjct: 1158 KQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVP 1217
Query: 1243 LAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEE------ 1296
+ D D E R ++ + EE + + D++PEE
Sbjct: 1218 VTVDDDDDDNDPENRI-----------AKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTG 1266
Query: 1297 EEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEE 1356
++++E + EA NSE D D E + + ++ + GE +T +E
Sbjct: 1267 KQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSD--GESGEEKKTKPKE 1324
Query: 1357 REVLAGSETAEEKTIANKASSFSDV-AEEETWHQQDELVGKTAAAGKVVVEELARSGEEV 1415
+ + G + + ++ S F + EE +DE +T +A K +EE RS ++
Sbjct: 1325 HKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQK 1384
Query: 1416 PAAEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEGSEGQEAATGSGDGRQETGAAEKFR 1475
+ V + + E + +E+EE E +E + D + +K R
Sbjct: 1385 KKRRRIKV-QEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIR 1443
Query: 1476 LGLSREGERELSPESLQAMATLPVKPDFTETREKQQHMVQGESETADVSPNNMQV 1530
L + +L E+ A+ + RE+++ ++ E D SP +
Sbjct: 1444 KILK---DDKLRTETQNALKEEEERRKRIAEREREREKLREVIEIEDASPTKCPI 1495
Score = 53.5 bits (127), Expect = 2e-06
Identities = 60/269 (22%), Positives = 109/269 (40%), Gaps = 23/269 (8%)
Query: 404 DKKPSLPKSRKEKSTEKGEELKKAEGKVRKE-----REYVIPK-RNEIKENKTSVSAKFS 457
D +P K R K E+ ++A+ +V E E P+ R+ + +K +VS S
Sbjct: 1255 DDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGES 1314
Query: 458 AQEIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEG 517
+E KT KE KG+ ++V +D E++ E EV E + ++
Sbjct: 1315 GEEKKTKPKE------HKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRS 1368
Query: 518 QADVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDM 577
++ +S KK +E +S K+ + + E + E E EE+++D
Sbjct: 1369 AKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDE 1428
Query: 578 KTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIE 637
S + P + + D + T++ + ++E ++ R+ +
Sbjct: 1429 NDDSKS-----PGKGRKKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREKLREV- 1482
Query: 638 ESLEIEIEDQEITKADVETKPMPIDESFE 666
IEIED TK + TK + +DE E
Sbjct: 1483 ----IEIEDASPTKCPITTK-LVLDEDEE 1506
Score = 48.9 bits (115), Expect = 4e-05
Identities = 72/348 (20%), Positives = 137/348 (39%), Gaps = 58/348 (16%)
Query: 405 KKPSLPKSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTG 464
KK + K +K S + K+A+ + +N I E + Q+IK
Sbjct: 1138 KKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSD------EQKIKPV 1191
Query: 465 LKEVV---------TAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNE 515
+ +V ++ +E SK P V +DD +N + + ++E K S+E
Sbjct: 1192 TENLVLSSHTGFCQSSGDEALSKSVP-VTVDDDDDDNDPENRIAKKMLLEEIKANLSSDE 1250
Query: 516 EGQADVQMNG--------IPQSPLDDK-KDNLDPEKESETSSQKAPDARDNVKDENDGCS 566
+G +D + ++P D++ K+ ++ E +S++ K P R + S
Sbjct: 1251 DGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVS 1310
Query: 567 ESELEEDKQDMKTASST---SSRSHPYSSDSED----ESAVGDREAHTDSSTDESARRSS 619
+ E E+K+ +R S DSED ES V + + ++ R +
Sbjct: 1311 DGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAK 1370
Query: 620 SQELSEND-----KPRKSHLPIEESLEIEI------EDQEITKADVETKPMPIDESFENV 668
EL EN K ++ + ++E E E++E + + E + +E EN
Sbjct: 1371 KAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDEND 1430
Query: 669 LKEGTEKGTQEIAEGLS---------------EKSGKHVSAEEKEKDK 701
+ KG ++I + L E+ K ++ E+E++K
Sbjct: 1431 DSKSPGKGRKKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREK 1478
Score = 37.0 bits (84), Expect = 0.15
Identities = 54/256 (21%), Positives = 97/256 (37%), Gaps = 27/256 (10%)
Query: 959 MEDTASKREDGSEEAILGGEEPAKERKEVMRTETR--------LSPFTGEAEASRM---- 1006
++D+ S S A++ +E K+ K+++ T L T +E S
Sbjct: 293 LDDSCSGSVTYSYSALIVPKEMIKKAKKLIETTANMNSSYVKFLKQATDNSEISSATKLR 352
Query: 1007 QVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERP 1066
Q+ + K +ED+ E +A N+E + KE + + RK E+P
Sbjct: 353 QLKAFKSVLADIKKAHLALEEDLNSEFRAMDA-VNKEKNTKEHKVIDAKFETKARKGEKP 411
Query: 1067 KTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDA 1126
+L K D + E + K D+ Q + EE T E + E +
Sbjct: 412 -CALEKKDISKSEAKLSR--KQVDSEHMHQNVPTEEQRTNKSTGGEHKKSDRKEEPQYEP 468
Query: 1127 ENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGERLSEAR 1186
N + ++ P + ED IFE E ++E +++ +G G +E
Sbjct: 469 ANTSEDLDMDIVSVPSSVPED--------IFE---NLETAMEVQSSVDHQGDGSSGTEQE 517
Query: 1187 DTEHKDREELSSRENR 1202
+ +SS++NR
Sbjct: 518 VESSSVKLNISSKDNR 533
Score = 36.6 bits (83), Expect = 0.19
Identities = 142/741 (19%), Positives = 269/741 (36%), Gaps = 115/741 (15%)
Query: 864 AKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNL-----EHLHE 918
A DAV +K++ ++ ++ ET E LEK ++ A L+ EH+H+
Sbjct: 381 AMDAV--NKEKNTKEHKVIDAKFETKARKGEKPCALEKKDISKSEAKLSRKQVDSEHMHQ 438
Query: 919 VAALREAATS-------------EEGEAEGGVAVSDV--------GESEEEASIDLEDTG 957
E T+ EE + E D+ E+ +LE
Sbjct: 439 NVPTEEQRTNKSTGGEHKKSDRKEEPQYEPANTSEDLDMDIVSVPSSVPEDIFENLETAM 498
Query: 958 PMEDTASKREDGS-------EEAILGGEEPAKERKEVMRTETRLSPFTGEAEASRMQVS- 1009
++ + + DGS E + + +K+ + ++++T + T E VS
Sbjct: 499 EVQSSVDHQGDGSSGTEQEVESSSVKLNISSKDNRGGIKSKTT-AKVTKELYVKLTPVSL 557
Query: 1010 EGSPEEGSLAKEAFLCKEDVEGEEMVTEAE----ANREDDRKEILPKELDLARER---RK 1062
SP +G+ +E K+ + + + E D + ++ E+ L E R+
Sbjct: 558 SNSPIKGADCQEVPQDKDGYKSCGLNPKLEKCGLGQENSDNEHLVENEVSLLLEESDLRR 617
Query: 1063 AERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAP-PNE 1121
+ R KT+ + +E VT + + + KE+QKL + + ++ P PN+
Sbjct: 618 SPRVKTTPLRRPTETNPVTSNSDEECNETVKEKQKLSVPVRKKDKRNSSDSAIDNPKPNK 677
Query: 1122 MGSDAENEAPVEASELSDNPGLLGE------DSLKETVVPIFEATPGFEKSLENITALRK 1175
+ ++E + S+ + +L E S +T + L+
Sbjct: 678 LPKSKQSETVDQNSDSDEMLAILKEVSRMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDD 737
Query: 1176 EGGGERLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKVQAPEGLIP 1235
+G +R S ++ ++ S++ + K+ + E + E E K + G
Sbjct: 738 KGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAAR 797
Query: 1236 ATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPE 1295
T + KD DS E + G+D K +E +D E
Sbjct: 798 TT-KKRIPNTKDFDSS---EDEKHSKKGMD-----------NQGHKNLKTSQEGSSDDAE 842
Query: 1296 EEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAE 1355
++++E E D+++ ME K + V+ L G E + T+ E
Sbjct: 843 RKQERETFSSAEGTVDKDTT---IMELRDRLPKKQ-QASASTDGVDKL-SGKEQSFTSLE 897
Query: 1356 EREVLAGSETAEE---KTIANKASSFSDVAEE-------ETWHQQDELVGKTAAAGK--- 1402
R+V E ++ KT SD+AE+ + + D+ K K
Sbjct: 898 VRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKP 957
Query: 1403 -------VVVEELARSG----EEVPAAEEM--------TVTYTTEAGVGTPGALERKTSG 1443
+ +E+ S E++P EE+ + T G + KTS
Sbjct: 958 SDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTS- 1016
Query: 1444 LGQEQEEGSEGQEAATGSGDG-------RQETGA--AEKFRLGLSREGERELSPESLQAM 1494
++++E S+ E +TG GD + + GA EK R L + R+ S
Sbjct: 1017 --KKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDT 1074
Query: 1495 ATLPVKPDFTETREKQQHMVQ 1515
+K D + +K+ ++
Sbjct: 1075 EKYSMKEDGCNSSDKRLKRIE 1095
Score = 33.9 bits (76), Expect = 1.2
Identities = 25/99 (25%), Positives = 42/99 (42%), Gaps = 12/99 (12%)
Query: 541 EKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSSRSHPYSS-------- 592
E+ ETSS N + S S++ E+ ++ T+SS S+S S
Sbjct: 27 EESEETSSPPRLAMNQNTDKISGSGSNSDMMENSKEEGTSSSEKSKSSGSSRSKRKPSIV 86
Query: 593 ----DSEDESAVGDREAHTDSSTDESARRSSSQELSEND 627
+S+DE + D + D+S + S + Q L + D
Sbjct: 87 TKYVESDDEKPLDDETVNEDASNENSENDITMQSLPKED 125
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 80.9 bits (198), Expect = 9e-15
Identities = 222/1041 (21%), Positives = 391/1041 (37%), Gaps = 140/1041 (13%)
Query: 417 STEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQ-EIKTG----LKEVVTA 471
+T+K +EL+ KVR E E ++ + +E S S K + E + G L E
Sbjct: 1746 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1805
Query: 472 VEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPL 531
+ + + K +++ E+D + E E GE + + +A++ +
Sbjct: 1806 LRALAEEAKRQRQLAEEDAARQ-RAEAERVLAEKLAAIGEATRLKTEAEIALK------- 1857
Query: 532 DDKKDNLDPEKESETSSQKAPDARDNVK--DENDGCSESELEEDKQDMKTAS-STSSRSH 588
+ E E+E + A D + +E ++++EE ++ AS S R
Sbjct: 1858 -------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1910
Query: 589 PYSSDSEDESAVGDREAHTDSSTDESARRSSSQ---ELSENDKPRKSHLPIEESLEIEIE 645
D+ + + E ++ E A ++ EL + L +E E+E
Sbjct: 1911 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1970
Query: 646 DQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSKLW 705
Q A+ E + +E + L E Q A L E EE + + +
Sbjct: 1971 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA-ALEEVERLKAKVEEARRLRERAE 2029
Query: 706 EESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQK 765
+ES Q++ LA A +E A + ++ +Q +Q+
Sbjct: 2030 QESARQLQ----------------------LAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2067
Query: 766 TYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEF 825
TL++++++ D ++G+ EAA A EA ++A + A+ EE
Sbjct: 2068 --TLQQEQSV----------LDQLRGEAEAAR-RAAEEAEEARVQAEREAAQSRRQVEE- 2113
Query: 826 TEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTV 885
ER + A E R + ++ + + A ++A ++ E +
Sbjct: 2114 ---------AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2164
Query: 886 LETDKAASEGEQGL-EKAVLANEAAALNL---EHLHEVAALREAATSEEGEA-EGGVAVS 940
E +K EQ L +KA + E L L E H+ L E + EA E S
Sbjct: 2165 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2224
Query: 941 DVGESEEEASIDLEDTGPMEDTASK-------REDGSEEAILGGEEPAKERKEVMRTETR 993
V E + +E+ ++ R+ + + L +E A++ K+V R
Sbjct: 2225 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL--QEEAEKMKQVAEEAAR 2282
Query: 994 LSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKE 1053
LS EA R E ++ +LA E + E+M EA R E+L ++
Sbjct: 2283 LSVAAQEAARLRQLAEEDLAQQRALA-------EKMLKEKMQAVQEATRLKAEAELLQQQ 2335
Query: 1054 LDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAE- 1112
+LA+E+ R+ ++E++ + A E+ ++ L+AE + + E+ AE
Sbjct: 2336 KELAQEQ---------ARRLQEDKEQMAQQLA---EETQGFQRTLEAER-QRQLEMSAEA 2382
Query: 1113 EETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITA 1172
E K EM S A+ A +A +GE + + + T ++LE I
Sbjct: 2383 ERLKLRVAEM-SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT--LVQTLE-IQR 2438
Query: 1173 LRKEGGGERLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKVQAPEG 1232
+ + ERL EA +++E+L E L ++E VQ E
Sbjct: 2439 QQSDHDAERLREAIAELEREKEKLQQ--------------EAKLLQLKSEEMQTVQ-QEQ 2483
Query: 1233 LIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDE 1292
L+ T ++ + DS E E Q + Q+ VA+ + E+ R++ E
Sbjct: 2484 LLQETQALQQSFLSEKDSLLQRERFIE-QEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2542
Query: 1293 DPEE------EEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGG 1346
+ EE + E E R E +E + Q+ E + E L
Sbjct: 2543 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE-QQRRQQEELLAEENQRLREQLQLL 2601
Query: 1347 GETAETAAEEREVLAGSETAEEKTIANKASSF-SDVAEEETWHQQDELVGKTAA-----A 1400
E A E + S+ A KT+ N + AE E H D L K +A A
Sbjct: 2602 EEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEA 2661
Query: 1401 GKVVVEELARSGEEVPAAEEM 1421
G + EEL R + +E+
Sbjct: 2662 GILSAEELQRLAQGHTTVDEL 2682
Score = 72.0 bits (175), Expect = 4e-12
Identities = 212/1051 (20%), Positives = 408/1051 (38%), Gaps = 140/1051 (13%)
Query: 414 KEKSTEKGEELK-KAEGKVRKEREYVIPKRNEIKENKTSV--SAKFSAQEIKTGLKEVVT 470
K+++ + EEL+ +AE R+ R+ + + +++ + SA+ Q + E
Sbjct: 1531 KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA 1590
Query: 471 AVEEMTSKGKPGQEVLEDDQENTLKYEYE-----EDFEVDEEKQGEKSNEEGQADVQMNG 525
+E + L ++ E + + E E+ E + E+ K+NE + +Q
Sbjct: 1591 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1650
Query: 526 IPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSS 585
+ Q + EK+ E + + +AR K E + EL E + + + + +
Sbjct: 1651 VAQQK---SLAQAEAEKQKEEAER---EARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1704
Query: 586 RSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIE 645
+++ E ++ E R+ +EL+ + + + LE E+
Sbjct: 1705 AQQRLAAEQELI------RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1758
Query: 646 DQEITKADVETKPMPIDESFENVLKEGTEKGTQEI-AEG-----LSEKSGKHVSAEEKEK 699
+A++E + E + +EK Q + AE L+E++ + + E+ K
Sbjct: 1759 K---VRAEMEVL-LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1814
Query: 700 DKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKES 759
+ +L EE A+ + + + + A+G T E A E+
Sbjct: 1815 RQRQLAEEDAAR-----------QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1863
Query: 760 QQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQP 819
++L + + E++A QH+ ADI + + ++ + L + T Q
Sbjct: 1864 ERLRRLAEDEAFQRRRLEEQAAQHK-ADIEERLAQLRKASDSELERQKGLV--EDTLRQR 1920
Query: 820 ELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQ 879
EE E + E+ A G AE E LG S+ +K+ L EA ++
Sbjct: 1921 RQVEE--EILALKASFEKAAAGKAELE--LELGRIRSNAEDTLRSKEQAEL---EAARQR 1973
Query: 880 ALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAV 939
L E ++ E E+ ++K++ A E AA + AAL E + + E +
Sbjct: 1974 QL---AAEEERRRREAEERVQKSLAAEEEAARQRK-----AALEEVERLK-AKVEEARRL 2024
Query: 940 SDVGESEEEASIDLEDTGPMEDTASKREDGSEEA-ILGGEEPAKERKEVMRTETR-LSPF 997
+ E E + L ++ A KR E+A ++ +E ++ ++ E L
Sbjct: 2025 RERAEQESARQLQLA-----QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2079
Query: 998 TGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLA 1057
GEAEA+R E EE + E +E + V EAE ++ ++ A
Sbjct: 2080 RGEAEAARRAAEEA--EEARVQAE----REAAQSRRQVEEAERLKQSAEEQ--------A 2125
Query: 1058 RERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKA 1117
+ R +A+ LRK ++E+E RA A ++ A +++Q A + E E + E+T
Sbjct: 2126 QARAQAQAAAEKLRK-EAEQEAARRAQA--EQAALRQKQ---AADAEMEKHKKFAEQTLR 2179
Query: 1118 PPNEMGSDAENEAPVEASELSDNPGLLGED--SLKETVVPIFEATPGFEKSL-------E 1168
++ + ++ E LL E+ LK E+ L E
Sbjct: 2180 QKAQVEQEL-TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2238
Query: 1169 NITALRKEGGGE-RLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKV 1227
++ L+ E R RD ++ R E +K+ + ++AA EA ++
Sbjct: 2239 ELSKLKARIEAENRALILRDKDNTQR--FLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2296
Query: 1228 QAPEGLIPATGQAEELAAKDHDS---CAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEK 1284
A E L AE++ + + L+ AE +L+ Q+ +A+E ++
Sbjct: 2297 -AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE-------LLQQQKELAQEQARRLQE 2348
Query: 1285 FREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGD-------------MEGEGNTQ---- 1327
+E+ + EE + + TLE E + + + E + Q
Sbjct: 2349 DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2408
Query: 1328 ----------KNEGMGGGRVVAVEVLHGGGETAETAAEE-REVLAGSETAEEKTIANKAS 1376
+ E +V V+ L + ++ AE RE +A E +EK + +A
Sbjct: 2409 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK-LQQEAK 2467
Query: 1377 SFSDVAEEETWHQQDELVGKTAAAGKVVVEE 1407
+EE QQ++L+ +T A + + E
Sbjct: 2468 LLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2498
Score = 66.2 bits (160), Expect = 2e-10
Identities = 164/817 (20%), Positives = 333/817 (40%), Gaps = 119/817 (14%)
Query: 411 KSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVT 470
+S+++ E + + A + R+ RE E + K+ + + +A++ K L+EV
Sbjct: 1960 RSKEQAELEAARQRQLAAEEERRRREA------EERVQKSLAAEEEAARQRKAALEEV-- 2011
Query: 471 AVEEMTSKGKPGQEVLED-DQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQS 529
E + +K + + + E +QE+ + + ++ + EK++ A Q Q
Sbjct: 2012 --ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH--AFAVQQKEQELQQ 2067
Query: 530 PLDDKKDNLDPEK-ESETSSQKAPDARD-NVKDENDGCSESELEEDKQDMKTASSTSSRS 587
L ++ LD + E+E + + A +A + V+ E + E+ + +K ++ +++
Sbjct: 2068 TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2127
Query: 588 HPYSSDSEDE-SAVGDREAHTDSSTDESARRSSSQELSENDKPRK---SHLPIEESLEIE 643
+ + ++ ++EA + +++A R +E +K +K L + +E E
Sbjct: 2128 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2187
Query: 644 IEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSK 703
+ + + + + +DE + + E TE Q ++ E V EE K K++
Sbjct: 2188 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR-SQVEEELFSVRVQMEELSKLKAR 2246
Query: 704 LWEESTAQV-KDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQL 762
+ E+ A + +DK L+E + +A A ++ E A + E
Sbjct: 2247 IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA----RLSVAAQEAARLRQLAEEDLA 2302
Query: 763 VQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELA 822
Q+ L +K E+ +A Q + + K EA L + + + R + EQ +A
Sbjct: 2303 QQRA--LAEKMLKEKMQAVQ----EATRLKAEAELLQQQKELAQEQARRLQEDKEQ--MA 2354
Query: 823 EEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALM 882
++ E+ + G + EAE R+L + + E + L
Sbjct: 2355 QQLAEETQ-------GFQRTLEAERQRQL---------------------EMSAEAERLK 2386
Query: 883 LTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDV 942
L V E +A + E+ ++ +A + E LH E AT E+ + +
Sbjct: 2387 LRVAEMSRAQARAEEDAQR--FRKQAEEIG-EKLHRT----ELATQEKVTLVQTLEIQRQ 2439
Query: 943 GESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAE 1002
+S+ +A E +E K + ++ L EE ++E + ET+
Sbjct: 2440 -QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA-------- 2490
Query: 1003 ASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEM----VTEAEANREDDRKEILPKELDLAR 1058
+Q S S ++ L +E F+ +E + E++ V +A+ RE+ +++ E + R
Sbjct: 2491 ---LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2547
Query: 1059 -------ERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRA 1111
RR+ + +R+ E +++ + ++E +E Q+L+ + E + RA
Sbjct: 2548 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2607
Query: 1112 EEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENIT 1171
S+ + V A++ N G D+L P EA P E S +
Sbjct: 2608 A--------LAHSEEVTASQVAATKTLPN----GRDALDG---PAAEAEP--EHSFD--- 2647
Query: 1172 ALRKEGGGERLSEARDTEHKDREELSSRENRALKEGH 1208
LR++ +RL EA LS+ E + L +GH
Sbjct: 2648 GLRRKVSAQRLQEA--------GILSAEELQRLAQGH 2676
Score = 59.7 bits (143), Expect = 2e-08
Identities = 118/545 (21%), Positives = 215/545 (39%), Gaps = 61/545 (11%)
Query: 886 LETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGES 945
+E ++ +E ++ E+ LA AAL + A + A +E E + +
Sbjct: 1344 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1403
Query: 946 EEEASIDLED--TGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEA 1003
EEA++D + E+ R+ E + + +R E + + EA
Sbjct: 1404 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1463
Query: 1004 SRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKA 1063
+ Q E +L A E+ E ++ + EA R R+++ D ++ +R+A
Sbjct: 1464 TERQRGGAEGELQALRARA----EEAEAQKRQAQEEAERL--RRQV----QDESQRKRQA 1513
Query: 1064 ERPKTSLRKTDSE--REEVTRANALKDEDAFKEEQKLKAEEGE---TETEVRAEEETKAP 1118
E S K ++E RE+ AL EE +L+AEE E + EV + +
Sbjct: 1514 EVELASRVKAEAEAAREKQRALQAL-------EELRLQAEEAERRLRQAEVERARQVQVA 1566
Query: 1119 PNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGG 1178
AE E + + ++ L E SL+E V + + E+ + ++
Sbjct: 1567 LETAQRSAEAELQSKRASFAEKTAQL-ERSLQEEHVAVAQLREEAERRAQ------QQAE 1619
Query: 1179 GERLSEARDTEHKDREELSSRENRALK---EGHRQDGEGALAAPEAEPAGKVQAPEGLIP 1235
ER AR+ ++ E + N AL+ + + +LA EAE + + E
Sbjct: 1620 AER---AREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK--QKEEAEREAR 1674
Query: 1236 ATGQAEELAAKDHDSC-AGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDP 1294
G+AEE A + + LE + + G Q+ +A E ++ + E ++
Sbjct: 1675 RRGKAEEQAVRQRELAEQELEKQRQLAEGT-----AQQRLAAEQELIRLRAETEQGEQQR 1729
Query: 1295 EEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAA 1354
+ E++ L+ EA + + E + E + + A E T+E +
Sbjct: 1730 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE---ESRSTSEKSK 1786
Query: 1355 EEREVLAG------SETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEEL 1408
+ E AG E A + +A +A +AEE+ Q+ A A +V+ E+L
Sbjct: 1787 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR-------AEAERVLAEKL 1839
Query: 1409 ARSGE 1413
A GE
Sbjct: 1840 AAIGE 1844
Score = 51.2 bits (121), Expect = 8e-06
Identities = 106/492 (21%), Positives = 188/492 (38%), Gaps = 58/492 (11%)
Query: 1032 EEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDA 1091
EE AE R ++R+ + E++ A E+++ + K +ERE +++E
Sbjct: 1345 EEEERLAEQQRAEERERLA--EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1402
Query: 1092 FKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKE 1151
+EE + A++ + + ++ ++ S+AE +A +E ++ L E+ ++
Sbjct: 1403 RREEAAVDAQQQKRSIQEELQQLRQS------SEAEIQAKARQAEAAERSRLRIEEEIRV 1456
Query: 1152 TVVPIFEATP----GFEKSLENITALRKEGGGERLSEARDTEHKDRE------------- 1194
+ + EAT G E L+ + A +E ++ + E R+
Sbjct: 1457 VRLQL-EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1515
Query: 1195 ELSSR---ENRALKEGHR------------QDGEGALAAPEAEPAGKVQAPEGLIPATGQ 1239
EL+SR E A +E R ++ E L E E A +VQ + +
Sbjct: 1516 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1575
Query: 1240 AE--ELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEE 1297
AE A + A LE + + LR + + AE+ REEA E +
Sbjct: 1576 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1635
Query: 1298 EDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEER 1357
L + ++ + E QK E A G+ E A +R
Sbjct: 1636 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE--------AEREARRRGKAEEQAVRQR 1687
Query: 1358 EVLAGSETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEELARSGEEVPA 1417
E LA E +++ +A + AE+E + E + +++ EELAR E A
Sbjct: 1688 E-LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE-TEQGEQQRQLLEEELARLQREAAA 1745
Query: 1418 AEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEG---SEGQEAATGSGDGRQETGAAEKF 1474
A + E +E + + +EE SE + + GR A E
Sbjct: 1746 ATQKRQELEAEL-AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA 1804
Query: 1475 RL-GLSREGERE 1485
RL L+ E +R+
Sbjct: 1805 RLRALAEEAKRQ 1816
Score = 39.7 bits (91), Expect = 0.023
Identities = 154/756 (20%), Positives = 270/756 (35%), Gaps = 113/756 (14%)
Query: 800 EAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAEG----AAEAEGVRRLGEGG 855
E VH L K A E A+ E+++ +E +G +AEAE V L E
Sbjct: 1000 ETRTVHRLRLPLDKEPAR--ECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1057
Query: 856 -SDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANE------- 907
+ P ++ + +G ++ A+ L L+T G QG E+ + A+E
Sbjct: 1058 PAAPTLRSELELTLG-KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ 1116
Query: 908 AAALNLEHLHEV-AALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKR 966
A L L A+L++ E + A+ D +E L+ D +R
Sbjct: 1117 AVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1176
Query: 967 --EDGSE-----EAILGGEEPAKERKEVMRTETR--------LSPFTGEAEASRMQV--- 1008
E ++ +A+L + + E + + R L + +A + Q+
Sbjct: 1177 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1236
Query: 1009 --SEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERP 1066
++ L +E L +E E V E + + I EL L + + E
Sbjct: 1237 PLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV 1296
Query: 1067 KTSLRK------TDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPN 1120
+ +K ++S +E E Q +K +ET R EEE +
Sbjct: 1297 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI---SETLRRMEEEERLAEQ 1353
Query: 1121 EMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGE 1180
+ + E A VEA+ EK + + +
Sbjct: 1354 QRAEERERLAEVEAA---------------------------LEKQ-RQLAEAHAQAKAQ 1385
Query: 1181 RLSEARDTEHKDREELSSRENRAL-----KEGHRQDGEGALAAPEAEPAGKVQAPEGLIP 1235
EA++ + + +EE+ RE A+ K +++ + + EAE K + E
Sbjct: 1386 AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1445
Query: 1236 ATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEA--VDED 1293
+ + EE + LE +GG + L+ A AEE + +EEA +
Sbjct: 1446 SRLRIEE---EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1502
Query: 1294 PEEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETA 1353
++E ++ E E +E + E + Q A+E L E AE
Sbjct: 1503 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQ-----------ALEELRLQAEEAERR 1551
Query: 1354 AEE------REVLAGSETAE---EKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVV 1404
+ R+V ETA+ E + +K +SF++ + Q+E V A +
Sbjct: 1552 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV--AVAQLREE 1609
Query: 1405 VEELARSGEEVPAAEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEGSEGQEAATGSGDG 1464
E A+ E A E + AL L + EE ++ + A +
Sbjct: 1610 AERRAQQQAEAERAREEAERELERWQLKANEALR-----LRLQAEEVAQQKSLAQAEAEK 1664
Query: 1465 RQETGAAEKFRLGLSRE---GERELSPESLQAMATL 1497
++E E R G + E +REL+ + L+ L
Sbjct: 1665 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1700
Score = 37.7 bits (86), Expect = 0.086
Identities = 49/210 (23%), Positives = 82/210 (39%), Gaps = 23/210 (10%)
Query: 457 SAQEIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQG----EK 512
SA+ TG K+ + + +L+D L+ + +D E+ E
Sbjct: 4006 SAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEV 4065
Query: 513 SNEEGQADVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEE 572
+ + G D +MN I P DD K DP E + + + + D G L+E
Sbjct: 4066 AYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMER--CITDPQTGLCLLPLKE 4123
Query: 573 DKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKS 632
K++ KT+S +S R + D E + S E+ R+ ++
Sbjct: 4124 KKRERKTSSKSSVRKR--------RVVIVDPETGKEMSVYEAYRKGLID--------HQT 4167
Query: 633 HLPIEESLEIEIEDQEITKADVETKPMPID 662
+L + E E E E+ I+ +D K M ID
Sbjct: 4168 YLELSEQ-ECEWEEITISSSDGVVKSMIID 4196
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 80.9 bits (198), Expect = 9e-15
Identities = 222/1041 (21%), Positives = 391/1041 (37%), Gaps = 140/1041 (13%)
Query: 417 STEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQ-EIKTG----LKEVVTA 471
+T+K +EL+ KVR E E ++ + +E S S K + E + G L E
Sbjct: 1750 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1809
Query: 472 VEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPL 531
+ + + K +++ E+D + E E GE + + +A++ +
Sbjct: 1810 LRALAEEAKRQRQLAEEDAARQ-RAEAERVLAEKLAAIGEATRLKTEAEIALK------- 1861
Query: 532 DDKKDNLDPEKESETSSQKAPDARDNVK--DENDGCSESELEEDKQDMKTAS-STSSRSH 588
+ E E+E + A D + +E ++++EE ++ AS S R
Sbjct: 1862 -------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1914
Query: 589 PYSSDSEDESAVGDREAHTDSSTDESARRSSSQ---ELSENDKPRKSHLPIEESLEIEIE 645
D+ + + E ++ E A ++ EL + L +E E+E
Sbjct: 1915 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1974
Query: 646 DQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSKLW 705
Q A+ E + +E + L E Q A L E EE + + +
Sbjct: 1975 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA-ALEEVERLKAKVEEARRLRERAE 2033
Query: 706 EESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQK 765
+ES Q++ LA A +E A + ++ +Q +Q+
Sbjct: 2034 QESARQLQ----------------------LAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2071
Query: 766 TYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEF 825
TL++++++ D ++G+ EAA A EA ++A + A+ EE
Sbjct: 2072 --TLQQEQSV----------LDQLRGEAEAAR-RAAEEAEEARVQAEREAAQSRRQVEE- 2117
Query: 826 TEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTV 885
ER + A E R + ++ + + A ++A ++ E +
Sbjct: 2118 ---------AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2168
Query: 886 LETDKAASEGEQGL-EKAVLANEAAALNL---EHLHEVAALREAATSEEGEA-EGGVAVS 940
E +K EQ L +KA + E L L E H+ L E + EA E S
Sbjct: 2169 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2228
Query: 941 DVGESEEEASIDLEDTGPMEDTASK-------REDGSEEAILGGEEPAKERKEVMRTETR 993
V E + +E+ ++ R+ + + L +E A++ K+V R
Sbjct: 2229 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL--QEEAEKMKQVAEEAAR 2286
Query: 994 LSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKE 1053
LS EA R E ++ +LA E + E+M EA R E+L ++
Sbjct: 2287 LSVAAQEAARLRQLAEEDLAQQRALA-------EKMLKEKMQAVQEATRLKAEAELLQQQ 2339
Query: 1054 LDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAE- 1112
+LA+E+ R+ ++E++ + A E+ ++ L+AE + + E+ AE
Sbjct: 2340 KELAQEQ---------ARRLQEDKEQMAQQLA---EETQGFQRTLEAER-QRQLEMSAEA 2386
Query: 1113 EETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITA 1172
E K EM S A+ A +A +GE + + + T ++LE I
Sbjct: 2387 ERLKLRVAEM-SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT--LVQTLE-IQR 2442
Query: 1173 LRKEGGGERLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKVQAPEG 1232
+ + ERL EA +++E+L E L ++E VQ E
Sbjct: 2443 QQSDHDAERLREAIAELEREKEKLQQ--------------EAKLLQLKSEEMQTVQ-QEQ 2487
Query: 1233 LIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDE 1292
L+ T ++ + DS E E Q + Q+ VA+ + E+ R++ E
Sbjct: 2488 LLQETQALQQSFLSEKDSLLQRERFIE-QEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2546
Query: 1293 DPEE------EEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGG 1346
+ EE + E E R E +E + Q+ E + E L
Sbjct: 2547 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE-QQRRQQEELLAEENQRLREQLQLL 2605
Query: 1347 GETAETAAEEREVLAGSETAEEKTIANKASSF-SDVAEEETWHQQDELVGKTAA-----A 1400
E A E + S+ A KT+ N + AE E H D L K +A A
Sbjct: 2606 EEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEA 2665
Query: 1401 GKVVVEELARSGEEVPAAEEM 1421
G + EEL R + +E+
Sbjct: 2666 GILSAEELQRLAQGHTTVDEL 2686
Score = 72.0 bits (175), Expect = 4e-12
Identities = 212/1051 (20%), Positives = 408/1051 (38%), Gaps = 140/1051 (13%)
Query: 414 KEKSTEKGEELK-KAEGKVRKEREYVIPKRNEIKENKTSV--SAKFSAQEIKTGLKEVVT 470
K+++ + EEL+ +AE R+ R+ + + +++ + SA+ Q + E
Sbjct: 1535 KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA 1594
Query: 471 AVEEMTSKGKPGQEVLEDDQENTLKYEYE-----EDFEVDEEKQGEKSNEEGQADVQMNG 525
+E + L ++ E + + E E+ E + E+ K+NE + +Q
Sbjct: 1595 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1654
Query: 526 IPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSS 585
+ Q + EK+ E + + +AR K E + EL E + + + + +
Sbjct: 1655 VAQQK---SLAQAEAEKQKEEAER---EARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1708
Query: 586 RSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIE 645
+++ E ++ E R+ +EL+ + + + LE E+
Sbjct: 1709 AQQRLAAEQELI------RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1762
Query: 646 DQEITKADVETKPMPIDESFENVLKEGTEKGTQEI-AEG-----LSEKSGKHVSAEEKEK 699
+A++E + E + +EK Q + AE L+E++ + + E+ K
Sbjct: 1763 K---VRAEMEVL-LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1818
Query: 700 DKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKES 759
+ +L EE A+ + + + + A+G T E A E+
Sbjct: 1819 RQRQLAEEDAAR-----------QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1867
Query: 760 QQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQP 819
++L + + E++A QH+ ADI + + ++ + L + T Q
Sbjct: 1868 ERLRRLAEDEAFQRRRLEEQAAQHK-ADIEERLAQLRKASDSELERQKGLV--EDTLRQR 1924
Query: 820 ELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQ 879
EE E + E+ A G AE E LG S+ +K+ L EA ++
Sbjct: 1925 RQVEE--EILALKASFEKAAAGKAELE--LELGRIRSNAEDTLRSKEQAEL---EAARQR 1977
Query: 880 ALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAV 939
L E ++ E E+ ++K++ A E AA + AAL E + + E +
Sbjct: 1978 QL---AAEEERRRREAEERVQKSLAAEEEAARQRK-----AALEEVERLK-AKVEEARRL 2028
Query: 940 SDVGESEEEASIDLEDTGPMEDTASKREDGSEEA-ILGGEEPAKERKEVMRTETR-LSPF 997
+ E E + L ++ A KR E+A ++ +E ++ ++ E L
Sbjct: 2029 RERAEQESARQLQLA-----QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2083
Query: 998 TGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLA 1057
GEAEA+R E EE + E +E + V EAE ++ ++ A
Sbjct: 2084 RGEAEAARRAAEEA--EEARVQAE----REAAQSRRQVEEAERLKQSAEEQ--------A 2129
Query: 1058 RERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKA 1117
+ R +A+ LRK ++E+E RA A ++ A +++Q A + E E + E+T
Sbjct: 2130 QARAQAQAAAEKLRK-EAEQEAARRAQA--EQAALRQKQ---AADAEMEKHKKFAEQTLR 2183
Query: 1118 PPNEMGSDAENEAPVEASELSDNPGLLGED--SLKETVVPIFEATPGFEKSL-------E 1168
++ + ++ E LL E+ LK E+ L E
Sbjct: 2184 QKAQVEQEL-TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2242
Query: 1169 NITALRKEGGGE-RLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKV 1227
++ L+ E R RD ++ R E +K+ + ++AA EA ++
Sbjct: 2243 ELSKLKARIEAENRALILRDKDNTQR--FLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2300
Query: 1228 QAPEGLIPATGQAEELAAKDHDS---CAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEK 1284
A E L AE++ + + L+ AE +L+ Q+ +A+E ++
Sbjct: 2301 -AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE-------LLQQQKELAQEQARRLQE 2352
Query: 1285 FREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGD-------------MEGEGNTQ---- 1327
+E+ + EE + + TLE E + + + E + Q
Sbjct: 2353 DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2412
Query: 1328 ----------KNEGMGGGRVVAVEVLHGGGETAETAAEE-REVLAGSETAEEKTIANKAS 1376
+ E +V V+ L + ++ AE RE +A E +EK + +A
Sbjct: 2413 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK-LQQEAK 2471
Query: 1377 SFSDVAEEETWHQQDELVGKTAAAGKVVVEE 1407
+EE QQ++L+ +T A + + E
Sbjct: 2472 LLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2502
Score = 66.2 bits (160), Expect = 2e-10
Identities = 164/817 (20%), Positives = 333/817 (40%), Gaps = 119/817 (14%)
Query: 411 KSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVT 470
+S+++ E + + A + R+ RE E + K+ + + +A++ K L+EV
Sbjct: 1964 RSKEQAELEAARQRQLAAEEERRRREA------EERVQKSLAAEEEAARQRKAALEEV-- 2015
Query: 471 AVEEMTSKGKPGQEVLED-DQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQS 529
E + +K + + + E +QE+ + + ++ + EK++ A Q Q
Sbjct: 2016 --ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH--AFAVQQKEQELQQ 2071
Query: 530 PLDDKKDNLDPEK-ESETSSQKAPDARD-NVKDENDGCSESELEEDKQDMKTASSTSSRS 587
L ++ LD + E+E + + A +A + V+ E + E+ + +K ++ +++
Sbjct: 2072 TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2131
Query: 588 HPYSSDSEDE-SAVGDREAHTDSSTDESARRSSSQELSENDKPRK---SHLPIEESLEIE 643
+ + ++ ++EA + +++A R +E +K +K L + +E E
Sbjct: 2132 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2191
Query: 644 IEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSK 703
+ + + + + +DE + + E TE Q ++ E V EE K K++
Sbjct: 2192 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR-SQVEEELFSVRVQMEELSKLKAR 2250
Query: 704 LWEESTAQV-KDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQL 762
+ E+ A + +DK L+E + +A A ++ E A + E
Sbjct: 2251 IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA----RLSVAAQEAARLRQLAEEDLA 2306
Query: 763 VQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELA 822
Q+ L +K E+ +A Q + + K EA L + + + R + EQ +A
Sbjct: 2307 QQRA--LAEKMLKEKMQAVQ----EATRLKAEAELLQQQKELAQEQARRLQEDKEQ--MA 2358
Query: 823 EEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALM 882
++ E+ + G + EAE R+L + + E + L
Sbjct: 2359 QQLAEETQ-------GFQRTLEAERQRQL---------------------EMSAEAERLK 2390
Query: 883 LTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDV 942
L V E +A + E+ ++ +A + E LH E AT E+ + +
Sbjct: 2391 LRVAEMSRAQARAEEDAQR--FRKQAEEIG-EKLHRT----ELATQEKVTLVQTLEIQRQ 2443
Query: 943 GESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAE 1002
+S+ +A E +E K + ++ L EE ++E + ET+
Sbjct: 2444 -QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA-------- 2494
Query: 1003 ASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEM----VTEAEANREDDRKEILPKELDLAR 1058
+Q S S ++ L +E F+ +E + E++ V +A+ RE+ +++ E + R
Sbjct: 2495 ---LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2551
Query: 1059 -------ERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRA 1111
RR+ + +R+ E +++ + ++E +E Q+L+ + E + RA
Sbjct: 2552 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2611
Query: 1112 EEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENIT 1171
S+ + V A++ N G D+L P EA P E S +
Sbjct: 2612 A--------LAHSEEVTASQVAATKTLPN----GRDALDG---PAAEAEP--EHSFD--- 2651
Query: 1172 ALRKEGGGERLSEARDTEHKDREELSSRENRALKEGH 1208
LR++ +RL EA LS+ E + L +GH
Sbjct: 2652 GLRRKVSAQRLQEA--------GILSAEELQRLAQGH 2680
Score = 59.7 bits (143), Expect = 2e-08
Identities = 118/545 (21%), Positives = 215/545 (39%), Gaps = 61/545 (11%)
Query: 886 LETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGES 945
+E ++ +E ++ E+ LA AAL + A + A +E E + +
Sbjct: 1348 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1407
Query: 946 EEEASIDLED--TGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEA 1003
EEA++D + E+ R+ E + + +R E + + EA
Sbjct: 1408 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1467
Query: 1004 SRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKA 1063
+ Q E +L A E+ E ++ + EA R R+++ D ++ +R+A
Sbjct: 1468 TERQRGGAEGELQALRARA----EEAEAQKRQAQEEAERL--RRQV----QDESQRKRQA 1517
Query: 1064 ERPKTSLRKTDSE--REEVTRANALKDEDAFKEEQKLKAEEGE---TETEVRAEEETKAP 1118
E S K ++E RE+ AL EE +L+AEE E + EV + +
Sbjct: 1518 EVELASRVKAEAEAAREKQRALQAL-------EELRLQAEEAERRLRQAEVERARQVQVA 1570
Query: 1119 PNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGG 1178
AE E + + ++ L E SL+E V + + E+ + ++
Sbjct: 1571 LETAQRSAEAELQSKRASFAEKTAQL-ERSLQEEHVAVAQLREEAERRAQ------QQAE 1623
Query: 1179 GERLSEARDTEHKDREELSSRENRALK---EGHRQDGEGALAAPEAEPAGKVQAPEGLIP 1235
ER AR+ ++ E + N AL+ + + +LA EAE + + E
Sbjct: 1624 AER---AREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK--QKEEAEREAR 1678
Query: 1236 ATGQAEELAAKDHDSC-AGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDP 1294
G+AEE A + + LE + + G Q+ +A E ++ + E ++
Sbjct: 1679 RRGKAEEQAVRQRELAEQELEKQRQLAEGT-----AQQRLAAEQELIRLRAETEQGEQQR 1733
Query: 1295 EEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAA 1354
+ E++ L+ EA + + E + E + + A E T+E +
Sbjct: 1734 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE---ESRSTSEKSK 1790
Query: 1355 EEREVLAG------SETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEEL 1408
+ E AG E A + +A +A +AEE+ Q+ A A +V+ E+L
Sbjct: 1791 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR-------AEAERVLAEKL 1843
Query: 1409 ARSGE 1413
A GE
Sbjct: 1844 AAIGE 1848
Score = 51.2 bits (121), Expect = 8e-06
Identities = 106/492 (21%), Positives = 188/492 (38%), Gaps = 58/492 (11%)
Query: 1032 EEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDA 1091
EE AE R ++R+ + E++ A E+++ + K +ERE +++E
Sbjct: 1349 EEEERLAEQQRAEERERLA--EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1406
Query: 1092 FKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKE 1151
+EE + A++ + + ++ ++ S+AE +A +E ++ L E+ ++
Sbjct: 1407 RREEAAVDAQQQKRSIQEELQQLRQS------SEAEIQAKARQAEAAERSRLRIEEEIRV 1460
Query: 1152 TVVPIFEATP----GFEKSLENITALRKEGGGERLSEARDTEHKDRE------------- 1194
+ + EAT G E L+ + A +E ++ + E R+
Sbjct: 1461 VRLQL-EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1519
Query: 1195 ELSSR---ENRALKEGHR------------QDGEGALAAPEAEPAGKVQAPEGLIPATGQ 1239
EL+SR E A +E R ++ E L E E A +VQ + +
Sbjct: 1520 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1579
Query: 1240 AE--ELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEE 1297
AE A + A LE + + LR + + AE+ REEA E +
Sbjct: 1580 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1639
Query: 1298 EDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEER 1357
L + ++ + E QK E A G+ E A +R
Sbjct: 1640 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE--------AEREARRRGKAEEQAVRQR 1691
Query: 1358 EVLAGSETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEELARSGEEVPA 1417
E LA E +++ +A + AE+E + E + +++ EELAR E A
Sbjct: 1692 E-LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE-TEQGEQQRQLLEEELARLQREAAA 1749
Query: 1418 AEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEG---SEGQEAATGSGDGRQETGAAEKF 1474
A + E +E + + +EE SE + + GR A E
Sbjct: 1750 ATQKRQELEAEL-AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA 1808
Query: 1475 RL-GLSREGERE 1485
RL L+ E +R+
Sbjct: 1809 RLRALAEEAKRQ 1820
Score = 39.7 bits (91), Expect = 0.023
Identities = 154/756 (20%), Positives = 270/756 (35%), Gaps = 113/756 (14%)
Query: 800 EAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAEG----AAEAEGVRRLGEGG 855
E VH L K A E A+ E+++ +E +G +AEAE V L E
Sbjct: 1004 ETRTVHRLRLPLDKEPAR--ECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1061
Query: 856 -SDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANE------- 907
+ P ++ + +G ++ A+ L L+T G QG E+ + A+E
Sbjct: 1062 PAAPTLRSELELTLG-KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ 1120
Query: 908 AAALNLEHLHEV-AALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKR 966
A L L A+L++ E + A+ D +E L+ D +R
Sbjct: 1121 AVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1180
Query: 967 --EDGSE-----EAILGGEEPAKERKEVMRTETR--------LSPFTGEAEASRMQV--- 1008
E ++ +A+L + + E + + R L + +A + Q+
Sbjct: 1181 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1240
Query: 1009 --SEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERP 1066
++ L +E L +E E V E + + I EL L + + E
Sbjct: 1241 PLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV 1300
Query: 1067 KTSLRK------TDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPN 1120
+ +K ++S +E E Q +K +ET R EEE +
Sbjct: 1301 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI---SETLRRMEEEERLAEQ 1357
Query: 1121 EMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGE 1180
+ + E A VEA+ EK + + +
Sbjct: 1358 QRAEERERLAEVEAA---------------------------LEKQ-RQLAEAHAQAKAQ 1389
Query: 1181 RLSEARDTEHKDREELSSRENRAL-----KEGHRQDGEGALAAPEAEPAGKVQAPEGLIP 1235
EA++ + + +EE+ RE A+ K +++ + + EAE K + E
Sbjct: 1390 AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1449
Query: 1236 ATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEA--VDED 1293
+ + EE + LE +GG + L+ A AEE + +EEA +
Sbjct: 1450 SRLRIEE---EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1506
Query: 1294 PEEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETA 1353
++E ++ E E +E + E + Q A+E L E AE
Sbjct: 1507 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQ-----------ALEELRLQAEEAERR 1555
Query: 1354 AEE------REVLAGSETAE---EKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVV 1404
+ R+V ETA+ E + +K +SF++ + Q+E V A +
Sbjct: 1556 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV--AVAQLREE 1613
Query: 1405 VEELARSGEEVPAAEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEGSEGQEAATGSGDG 1464
E A+ E A E + AL L + EE ++ + A +
Sbjct: 1614 AERRAQQQAEAERAREEAERELERWQLKANEALR-----LRLQAEEVAQQKSLAQAEAEK 1668
Query: 1465 RQETGAAEKFRLGLSRE---GERELSPESLQAMATL 1497
++E E R G + E +REL+ + L+ L
Sbjct: 1669 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1704
Score = 37.7 bits (86), Expect = 0.086
Identities = 49/210 (23%), Positives = 82/210 (39%), Gaps = 23/210 (10%)
Query: 457 SAQEIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQG----EK 512
SA+ TG K+ + + +L+D L+ + +D E+ E
Sbjct: 4010 SAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEV 4069
Query: 513 SNEEGQADVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEE 572
+ + G D +MN I P DD K DP E + + + + D G L+E
Sbjct: 4070 AYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMER--CITDPQTGLCLLPLKE 4127
Query: 573 DKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKS 632
K++ KT+S +S R + D E + S E+ R+ ++
Sbjct: 4128 KKRERKTSSKSSVRKR--------RVVIVDPETGKEMSVYEAYRKGLID--------HQT 4171
Query: 633 HLPIEESLEIEIEDQEITKADVETKPMPID 662
+L + E E E E+ I+ +D K M ID
Sbjct: 4172 YLELSEQ-ECEWEEITISSSDGVVKSMIID 4200
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 80.9 bits (198), Expect = 9e-15
Identities = 222/1041 (21%), Positives = 391/1041 (37%), Gaps = 140/1041 (13%)
Query: 417 STEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQ-EIKTG----LKEVVTA 471
+T+K +EL+ KVR E E ++ + +E S S K + E + G L E
Sbjct: 1746 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1805
Query: 472 VEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPL 531
+ + + K +++ E+D + E E GE + + +A++ +
Sbjct: 1806 LRALAEEAKRQRQLAEEDAARQ-RAEAERVLAEKLAAIGEATRLKTEAEIALK------- 1857
Query: 532 DDKKDNLDPEKESETSSQKAPDARDNVK--DENDGCSESELEEDKQDMKTAS-STSSRSH 588
+ E E+E + A D + +E ++++EE ++ AS S R
Sbjct: 1858 -------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1910
Query: 589 PYSSDSEDESAVGDREAHTDSSTDESARRSSSQ---ELSENDKPRKSHLPIEESLEIEIE 645
D+ + + E ++ E A ++ EL + L +E E+E
Sbjct: 1911 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1970
Query: 646 DQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSKLW 705
Q A+ E + +E + L E Q A L E EE + + +
Sbjct: 1971 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA-ALEEVERLKAKVEEARRLRERAE 2029
Query: 706 EESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQK 765
+ES Q++ LA A +E A + ++ +Q +Q+
Sbjct: 2030 QESARQLQ----------------------LAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2067
Query: 766 TYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEF 825
TL++++++ D ++G+ EAA A EA ++A + A+ EE
Sbjct: 2068 --TLQQEQSV----------LDQLRGEAEAAR-RAAEEAEEARVQAEREAAQSRRQVEE- 2113
Query: 826 TEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTV 885
ER + A E R + ++ + + A ++A ++ E +
Sbjct: 2114 ---------AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2164
Query: 886 LETDKAASEGEQGL-EKAVLANEAAALNL---EHLHEVAALREAATSEEGEA-EGGVAVS 940
E +K EQ L +KA + E L L E H+ L E + EA E S
Sbjct: 2165 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2224
Query: 941 DVGESEEEASIDLEDTGPMEDTASK-------REDGSEEAILGGEEPAKERKEVMRTETR 993
V E + +E+ ++ R+ + + L +E A++ K+V R
Sbjct: 2225 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL--QEEAEKMKQVAEEAAR 2282
Query: 994 LSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKE 1053
LS EA R E ++ +LA E + E+M EA R E+L ++
Sbjct: 2283 LSVAAQEAARLRQLAEEDLAQQRALA-------EKMLKEKMQAVQEATRLKAEAELLQQQ 2335
Query: 1054 LDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAE- 1112
+LA+E+ R+ ++E++ + A E+ ++ L+AE + + E+ AE
Sbjct: 2336 KELAQEQ---------ARRLQEDKEQMAQQLA---EETQGFQRTLEAER-QRQLEMSAEA 2382
Query: 1113 EETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITA 1172
E K EM S A+ A +A +GE + + + T ++LE I
Sbjct: 2383 ERLKLRVAEM-SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT--LVQTLE-IQR 2438
Query: 1173 LRKEGGGERLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKVQAPEG 1232
+ + ERL EA +++E+L E L ++E VQ E
Sbjct: 2439 QQSDHDAERLREAIAELEREKEKLQQ--------------EAKLLQLKSEEMQTVQ-QEQ 2483
Query: 1233 LIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDE 1292
L+ T ++ + DS E E Q + Q+ VA+ + E+ R++ E
Sbjct: 2484 LLQETQALQQSFLSEKDSLLQRERFIE-QEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2542
Query: 1293 DPEE------EEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGG 1346
+ EE + E E R E +E + Q+ E + E L
Sbjct: 2543 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE-QQRRQQEELLAEENQRLREQLQLL 2601
Query: 1347 GETAETAAEEREVLAGSETAEEKTIANKASSF-SDVAEEETWHQQDELVGKTAA-----A 1400
E A E + S+ A KT+ N + AE E H D L K +A A
Sbjct: 2602 EEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEA 2661
Query: 1401 GKVVVEELARSGEEVPAAEEM 1421
G + EEL R + +E+
Sbjct: 2662 GILSAEELQRLAQGHTTVDEL 2682
Score = 72.0 bits (175), Expect = 4e-12
Identities = 212/1051 (20%), Positives = 408/1051 (38%), Gaps = 140/1051 (13%)
Query: 414 KEKSTEKGEELK-KAEGKVRKEREYVIPKRNEIKENKTSV--SAKFSAQEIKTGLKEVVT 470
K+++ + EEL+ +AE R+ R+ + + +++ + SA+ Q + E
Sbjct: 1531 KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA 1590
Query: 471 AVEEMTSKGKPGQEVLEDDQENTLKYEYE-----EDFEVDEEKQGEKSNEEGQADVQMNG 525
+E + L ++ E + + E E+ E + E+ K+NE + +Q
Sbjct: 1591 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1650
Query: 526 IPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSS 585
+ Q + EK+ E + + +AR K E + EL E + + + + +
Sbjct: 1651 VAQQK---SLAQAEAEKQKEEAER---EARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1704
Query: 586 RSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIE 645
+++ E ++ E R+ +EL+ + + + LE E+
Sbjct: 1705 AQQRLAAEQELI------RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1758
Query: 646 DQEITKADVETKPMPIDESFENVLKEGTEKGTQEI-AEG-----LSEKSGKHVSAEEKEK 699
+A++E + E + +EK Q + AE L+E++ + + E+ K
Sbjct: 1759 K---VRAEMEVL-LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1814
Query: 700 DKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKES 759
+ +L EE A+ + + + + A+G T E A E+
Sbjct: 1815 RQRQLAEEDAAR-----------QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1863
Query: 760 QQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQP 819
++L + + E++A QH+ ADI + + ++ + L + T Q
Sbjct: 1864 ERLRRLAEDEAFQRRRLEEQAAQHK-ADIEERLAQLRKASDSELERQKGLV--EDTLRQR 1920
Query: 820 ELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQ 879
EE E + E+ A G AE E LG S+ +K+ L EA ++
Sbjct: 1921 RQVEE--EILALKASFEKAAAGKAELE--LELGRIRSNAEDTLRSKEQAEL---EAARQR 1973
Query: 880 ALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAV 939
L E ++ E E+ ++K++ A E AA + AAL E + + E +
Sbjct: 1974 QL---AAEEERRRREAEERVQKSLAAEEEAARQRK-----AALEEVERLK-AKVEEARRL 2024
Query: 940 SDVGESEEEASIDLEDTGPMEDTASKREDGSEEA-ILGGEEPAKERKEVMRTETR-LSPF 997
+ E E + L ++ A KR E+A ++ +E ++ ++ E L
Sbjct: 2025 RERAEQESARQLQLA-----QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2079
Query: 998 TGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLA 1057
GEAEA+R E EE + E +E + V EAE ++ ++ A
Sbjct: 2080 RGEAEAARRAAEEA--EEARVQAE----REAAQSRRQVEEAERLKQSAEEQ--------A 2125
Query: 1058 RERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKA 1117
+ R +A+ LRK ++E+E RA A ++ A +++Q A + E E + E+T
Sbjct: 2126 QARAQAQAAAEKLRK-EAEQEAARRAQA--EQAALRQKQ---AADAEMEKHKKFAEQTLR 2179
Query: 1118 PPNEMGSDAENEAPVEASELSDNPGLLGED--SLKETVVPIFEATPGFEKSL-------E 1168
++ + ++ E LL E+ LK E+ L E
Sbjct: 2180 QKAQVEQEL-TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2238
Query: 1169 NITALRKEGGGE-RLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKV 1227
++ L+ E R RD ++ R E +K+ + ++AA EA ++
Sbjct: 2239 ELSKLKARIEAENRALILRDKDNTQR--FLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2296
Query: 1228 QAPEGLIPATGQAEELAAKDHDS---CAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEK 1284
A E L AE++ + + L+ AE +L+ Q+ +A+E ++
Sbjct: 2297 -AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE-------LLQQQKELAQEQARRLQE 2348
Query: 1285 FREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGD-------------MEGEGNTQ---- 1327
+E+ + EE + + TLE E + + + E + Q
Sbjct: 2349 DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2408
Query: 1328 ----------KNEGMGGGRVVAVEVLHGGGETAETAAEE-REVLAGSETAEEKTIANKAS 1376
+ E +V V+ L + ++ AE RE +A E +EK + +A
Sbjct: 2409 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK-LQQEAK 2467
Query: 1377 SFSDVAEEETWHQQDELVGKTAAAGKVVVEE 1407
+EE QQ++L+ +T A + + E
Sbjct: 2468 LLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2498
Score = 66.2 bits (160), Expect = 2e-10
Identities = 164/817 (20%), Positives = 333/817 (40%), Gaps = 119/817 (14%)
Query: 411 KSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVT 470
+S+++ E + + A + R+ RE E + K+ + + +A++ K L+EV
Sbjct: 1960 RSKEQAELEAARQRQLAAEEERRRREA------EERVQKSLAAEEEAARQRKAALEEV-- 2011
Query: 471 AVEEMTSKGKPGQEVLED-DQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQS 529
E + +K + + + E +QE+ + + ++ + EK++ A Q Q
Sbjct: 2012 --ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH--AFAVQQKEQELQQ 2067
Query: 530 PLDDKKDNLDPEK-ESETSSQKAPDARD-NVKDENDGCSESELEEDKQDMKTASSTSSRS 587
L ++ LD + E+E + + A +A + V+ E + E+ + +K ++ +++
Sbjct: 2068 TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2127
Query: 588 HPYSSDSEDE-SAVGDREAHTDSSTDESARRSSSQELSENDKPRK---SHLPIEESLEIE 643
+ + ++ ++EA + +++A R +E +K +K L + +E E
Sbjct: 2128 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2187
Query: 644 IEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSK 703
+ + + + + +DE + + E TE Q ++ E V EE K K++
Sbjct: 2188 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR-SQVEEELFSVRVQMEELSKLKAR 2246
Query: 704 LWEESTAQV-KDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQL 762
+ E+ A + +DK L+E + +A A ++ E A + E
Sbjct: 2247 IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA----RLSVAAQEAARLRQLAEEDLA 2302
Query: 763 VQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELA 822
Q+ L +K E+ +A Q + + K EA L + + + R + EQ +A
Sbjct: 2303 QQRA--LAEKMLKEKMQAVQ----EATRLKAEAELLQQQKELAQEQARRLQEDKEQ--MA 2354
Query: 823 EEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALM 882
++ E+ + G + EAE R+L + + E + L
Sbjct: 2355 QQLAEETQ-------GFQRTLEAERQRQL---------------------EMSAEAERLK 2386
Query: 883 LTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDV 942
L V E +A + E+ ++ +A + E LH E AT E+ + +
Sbjct: 2387 LRVAEMSRAQARAEEDAQR--FRKQAEEIG-EKLHRT----ELATQEKVTLVQTLEIQRQ 2439
Query: 943 GESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAE 1002
+S+ +A E +E K + ++ L EE ++E + ET+
Sbjct: 2440 -QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA-------- 2490
Query: 1003 ASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEM----VTEAEANREDDRKEILPKELDLAR 1058
+Q S S ++ L +E F+ +E + E++ V +A+ RE+ +++ E + R
Sbjct: 2491 ---LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2547
Query: 1059 -------ERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRA 1111
RR+ + +R+ E +++ + ++E +E Q+L+ + E + RA
Sbjct: 2548 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2607
Query: 1112 EEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENIT 1171
S+ + V A++ N G D+L P EA P E S +
Sbjct: 2608 A--------LAHSEEVTASQVAATKTLPN----GRDALDG---PAAEAEP--EHSFD--- 2647
Query: 1172 ALRKEGGGERLSEARDTEHKDREELSSRENRALKEGH 1208
LR++ +RL EA LS+ E + L +GH
Sbjct: 2648 GLRRKVSAQRLQEA--------GILSAEELQRLAQGH 2676
Score = 59.7 bits (143), Expect = 2e-08
Identities = 118/545 (21%), Positives = 215/545 (39%), Gaps = 61/545 (11%)
Query: 886 LETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGES 945
+E ++ +E ++ E+ LA AAL + A + A +E E + +
Sbjct: 1344 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1403
Query: 946 EEEASIDLED--TGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEA 1003
EEA++D + E+ R+ E + + +R E + + EA
Sbjct: 1404 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1463
Query: 1004 SRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKA 1063
+ Q E +L A E+ E ++ + EA R R+++ D ++ +R+A
Sbjct: 1464 TERQRGGAEGELQALRARA----EEAEAQKRQAQEEAERL--RRQV----QDESQRKRQA 1513
Query: 1064 ERPKTSLRKTDSE--REEVTRANALKDEDAFKEEQKLKAEEGE---TETEVRAEEETKAP 1118
E S K ++E RE+ AL EE +L+AEE E + EV + +
Sbjct: 1514 EVELASRVKAEAEAAREKQRALQAL-------EELRLQAEEAERRLRQAEVERARQVQVA 1566
Query: 1119 PNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGG 1178
AE E + + ++ L E SL+E V + + E+ + ++
Sbjct: 1567 LETAQRSAEAELQSKRASFAEKTAQL-ERSLQEEHVAVAQLREEAERRAQ------QQAE 1619
Query: 1179 GERLSEARDTEHKDREELSSRENRALK---EGHRQDGEGALAAPEAEPAGKVQAPEGLIP 1235
ER AR+ ++ E + N AL+ + + +LA EAE + + E
Sbjct: 1620 AER---AREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK--QKEEAEREAR 1674
Query: 1236 ATGQAEELAAKDHDSC-AGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDP 1294
G+AEE A + + LE + + G Q+ +A E ++ + E ++
Sbjct: 1675 RRGKAEEQAVRQRELAEQELEKQRQLAEGT-----AQQRLAAEQELIRLRAETEQGEQQR 1729
Query: 1295 EEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAA 1354
+ E++ L+ EA + + E + E + + A E T+E +
Sbjct: 1730 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE---ESRSTSEKSK 1786
Query: 1355 EEREVLAG------SETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEEL 1408
+ E AG E A + +A +A +AEE+ Q+ A A +V+ E+L
Sbjct: 1787 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR-------AEAERVLAEKL 1839
Query: 1409 ARSGE 1413
A GE
Sbjct: 1840 AAIGE 1844
Score = 51.2 bits (121), Expect = 8e-06
Identities = 106/492 (21%), Positives = 188/492 (38%), Gaps = 58/492 (11%)
Query: 1032 EEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDA 1091
EE AE R ++R+ + E++ A E+++ + K +ERE +++E
Sbjct: 1345 EEEERLAEQQRAEERERLA--EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1402
Query: 1092 FKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKE 1151
+EE + A++ + + ++ ++ S+AE +A +E ++ L E+ ++
Sbjct: 1403 RREEAAVDAQQQKRSIQEELQQLRQS------SEAEIQAKARQAEAAERSRLRIEEEIRV 1456
Query: 1152 TVVPIFEATP----GFEKSLENITALRKEGGGERLSEARDTEHKDRE------------- 1194
+ + EAT G E L+ + A +E ++ + E R+
Sbjct: 1457 VRLQL-EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1515
Query: 1195 ELSSR---ENRALKEGHR------------QDGEGALAAPEAEPAGKVQAPEGLIPATGQ 1239
EL+SR E A +E R ++ E L E E A +VQ + +
Sbjct: 1516 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1575
Query: 1240 AE--ELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEE 1297
AE A + A LE + + LR + + AE+ REEA E +
Sbjct: 1576 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1635
Query: 1298 EDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEER 1357
L + ++ + E QK E A G+ E A +R
Sbjct: 1636 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE--------AEREARRRGKAEEQAVRQR 1687
Query: 1358 EVLAGSETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEELARSGEEVPA 1417
E LA E +++ +A + AE+E + E + +++ EELAR E A
Sbjct: 1688 E-LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE-TEQGEQQRQLLEEELARLQREAAA 1745
Query: 1418 AEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEG---SEGQEAATGSGDGRQETGAAEKF 1474
A + E +E + + +EE SE + + GR A E
Sbjct: 1746 ATQKRQELEAEL-AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA 1804
Query: 1475 RL-GLSREGERE 1485
RL L+ E +R+
Sbjct: 1805 RLRALAEEAKRQ 1816
Score = 39.7 bits (91), Expect = 0.023
Identities = 154/756 (20%), Positives = 270/756 (35%), Gaps = 113/756 (14%)
Query: 800 EAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAEG----AAEAEGVRRLGEGG 855
E VH L K A E A+ E+++ +E +G +AEAE V L E
Sbjct: 1000 ETRTVHRLRLPLDKEPAR--ECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1057
Query: 856 -SDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANE------- 907
+ P ++ + +G ++ A+ L L+T G QG E+ + A+E
Sbjct: 1058 PAAPTLRSELELTLG-KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ 1116
Query: 908 AAALNLEHLHEV-AALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKR 966
A L L A+L++ E + A+ D +E L+ D +R
Sbjct: 1117 AVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1176
Query: 967 --EDGSE-----EAILGGEEPAKERKEVMRTETR--------LSPFTGEAEASRMQV--- 1008
E ++ +A+L + + E + + R L + +A + Q+
Sbjct: 1177 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1236
Query: 1009 --SEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERP 1066
++ L +E L +E E V E + + I EL L + + E
Sbjct: 1237 PLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV 1296
Query: 1067 KTSLRK------TDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPN 1120
+ +K ++S +E E Q +K +ET R EEE +
Sbjct: 1297 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI---SETLRRMEEEERLAEQ 1353
Query: 1121 EMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGE 1180
+ + E A VEA+ EK + + +
Sbjct: 1354 QRAEERERLAEVEAA---------------------------LEKQ-RQLAEAHAQAKAQ 1385
Query: 1181 RLSEARDTEHKDREELSSRENRAL-----KEGHRQDGEGALAAPEAEPAGKVQAPEGLIP 1235
EA++ + + +EE+ RE A+ K +++ + + EAE K + E
Sbjct: 1386 AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1445
Query: 1236 ATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEA--VDED 1293
+ + EE + LE +GG + L+ A AEE + +EEA +
Sbjct: 1446 SRLRIEE---EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1502
Query: 1294 PEEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETA 1353
++E ++ E E +E + E + Q A+E L E AE
Sbjct: 1503 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQ-----------ALEELRLQAEEAERR 1551
Query: 1354 AEE------REVLAGSETAE---EKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVV 1404
+ R+V ETA+ E + +K +SF++ + Q+E V A +
Sbjct: 1552 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV--AVAQLREE 1609
Query: 1405 VEELARSGEEVPAAEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEGSEGQEAATGSGDG 1464
E A+ E A E + AL L + EE ++ + A +
Sbjct: 1610 AERRAQQQAEAERAREEAERELERWQLKANEALR-----LRLQAEEVAQQKSLAQAEAEK 1664
Query: 1465 RQETGAAEKFRLGLSRE---GERELSPESLQAMATL 1497
++E E R G + E +REL+ + L+ L
Sbjct: 1665 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1700
Score = 37.7 bits (86), Expect = 0.086
Identities = 49/210 (23%), Positives = 82/210 (39%), Gaps = 23/210 (10%)
Query: 457 SAQEIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQG----EK 512
SA+ TG K+ + + +L+D L+ + +D E+ E
Sbjct: 4006 SAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEV 4065
Query: 513 SNEEGQADVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEE 572
+ + G D +MN I P DD K DP E + + + + D G L+E
Sbjct: 4066 AYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMER--CITDPQTGLCLLPLKE 4123
Query: 573 DKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKS 632
K++ KT+S +S R + D E + S E+ R+ ++
Sbjct: 4124 KKRERKTSSKSSVRKR--------RVVIVDPETGKEMSVYEAYRKGLID--------HQT 4167
Query: 633 HLPIEESLEIEIEDQEITKADVETKPMPID 662
+L + E E E E+ I+ +D K M ID
Sbjct: 4168 YLELSEQ-ECEWEEITISSSDGVVKSMIID 4196
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 80.9 bits (198), Expect = 9e-15
Identities = 222/1041 (21%), Positives = 391/1041 (37%), Gaps = 140/1041 (13%)
Query: 417 STEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQ-EIKTG----LKEVVTA 471
+T+K +EL+ KVR E E ++ + +E S S K + E + G L E
Sbjct: 1714 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1773
Query: 472 VEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPL 531
+ + + K +++ E+D + E E GE + + +A++ +
Sbjct: 1774 LRALAEEAKRQRQLAEEDAARQ-RAEAERVLAEKLAAIGEATRLKTEAEIALK------- 1825
Query: 532 DDKKDNLDPEKESETSSQKAPDARDNVK--DENDGCSESELEEDKQDMKTAS-STSSRSH 588
+ E E+E + A D + +E ++++EE ++ AS S R
Sbjct: 1826 -------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1878
Query: 589 PYSSDSEDESAVGDREAHTDSSTDESARRSSSQ---ELSENDKPRKSHLPIEESLEIEIE 645
D+ + + E ++ E A ++ EL + L +E E+E
Sbjct: 1879 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1938
Query: 646 DQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSKLW 705
Q A+ E + +E + L E Q A L E EE + + +
Sbjct: 1939 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA-ALEEVERLKAKVEEARRLRERAE 1997
Query: 706 EESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQK 765
+ES Q++ LA A +E A + ++ +Q +Q+
Sbjct: 1998 QESARQLQ----------------------LAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2035
Query: 766 TYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEF 825
TL++++++ D ++G+ EAA A EA ++A + A+ EE
Sbjct: 2036 --TLQQEQSV----------LDQLRGEAEAAR-RAAEEAEEARVQAEREAAQSRRQVEE- 2081
Query: 826 TEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTV 885
ER + A E R + ++ + + A ++A ++ E +
Sbjct: 2082 ---------AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2132
Query: 886 LETDKAASEGEQGL-EKAVLANEAAALNL---EHLHEVAALREAATSEEGEA-EGGVAVS 940
E +K EQ L +KA + E L L E H+ L E + EA E S
Sbjct: 2133 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2192
Query: 941 DVGESEEEASIDLEDTGPMEDTASK-------REDGSEEAILGGEEPAKERKEVMRTETR 993
V E + +E+ ++ R+ + + L +E A++ K+V R
Sbjct: 2193 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL--QEEAEKMKQVAEEAAR 2250
Query: 994 LSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKE 1053
LS EA R E ++ +LA E + E+M EA R E+L ++
Sbjct: 2251 LSVAAQEAARLRQLAEEDLAQQRALA-------EKMLKEKMQAVQEATRLKAEAELLQQQ 2303
Query: 1054 LDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAE- 1112
+LA+E+ R+ ++E++ + A E+ ++ L+AE + + E+ AE
Sbjct: 2304 KELAQEQ---------ARRLQEDKEQMAQQLA---EETQGFQRTLEAER-QRQLEMSAEA 2350
Query: 1113 EETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITA 1172
E K EM S A+ A +A +GE + + + T ++LE I
Sbjct: 2351 ERLKLRVAEM-SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT--LVQTLE-IQR 2406
Query: 1173 LRKEGGGERLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKVQAPEG 1232
+ + ERL EA +++E+L E L ++E VQ E
Sbjct: 2407 QQSDHDAERLREAIAELEREKEKLQQ--------------EAKLLQLKSEEMQTVQ-QEQ 2451
Query: 1233 LIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDE 1292
L+ T ++ + DS E E Q + Q+ VA+ + E+ R++ E
Sbjct: 2452 LLQETQALQQSFLSEKDSLLQRERFIE-QEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2510
Query: 1293 DPEE------EEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGG 1346
+ EE + E E R E +E + Q+ E + E L
Sbjct: 2511 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE-QQRRQQEELLAEENQRLREQLQLL 2569
Query: 1347 GETAETAAEEREVLAGSETAEEKTIANKASSF-SDVAEEETWHQQDELVGKTAA-----A 1400
E A E + S+ A KT+ N + AE E H D L K +A A
Sbjct: 2570 EEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEA 2629
Query: 1401 GKVVVEELARSGEEVPAAEEM 1421
G + EEL R + +E+
Sbjct: 2630 GILSAEELQRLAQGHTTVDEL 2650
Score = 72.0 bits (175), Expect = 4e-12
Identities = 212/1051 (20%), Positives = 408/1051 (38%), Gaps = 140/1051 (13%)
Query: 414 KEKSTEKGEELK-KAEGKVRKEREYVIPKRNEIKENKTSV--SAKFSAQEIKTGLKEVVT 470
K+++ + EEL+ +AE R+ R+ + + +++ + SA+ Q + E
Sbjct: 1499 KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA 1558
Query: 471 AVEEMTSKGKPGQEVLEDDQENTLKYEYE-----EDFEVDEEKQGEKSNEEGQADVQMNG 525
+E + L ++ E + + E E+ E + E+ K+NE + +Q
Sbjct: 1559 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1618
Query: 526 IPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSS 585
+ Q + EK+ E + + +AR K E + EL E + + + + +
Sbjct: 1619 VAQQK---SLAQAEAEKQKEEAER---EARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1672
Query: 586 RSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIE 645
+++ E ++ E R+ +EL+ + + + LE E+
Sbjct: 1673 AQQRLAAEQELI------RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1726
Query: 646 DQEITKADVETKPMPIDESFENVLKEGTEKGTQEI-AEG-----LSEKSGKHVSAEEKEK 699
+A++E + E + +EK Q + AE L+E++ + + E+ K
Sbjct: 1727 K---VRAEMEVL-LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1782
Query: 700 DKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKES 759
+ +L EE A+ + + + + A+G T E A E+
Sbjct: 1783 RQRQLAEEDAAR-----------QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1831
Query: 760 QQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQP 819
++L + + E++A QH+ ADI + + ++ + L + T Q
Sbjct: 1832 ERLRRLAEDEAFQRRRLEEQAAQHK-ADIEERLAQLRKASDSELERQKGLV--EDTLRQR 1888
Query: 820 ELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQ 879
EE E + E+ A G AE E LG S+ +K+ L EA ++
Sbjct: 1889 RQVEE--EILALKASFEKAAAGKAELE--LELGRIRSNAEDTLRSKEQAEL---EAARQR 1941
Query: 880 ALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAV 939
L E ++ E E+ ++K++ A E AA + AAL E + + E +
Sbjct: 1942 QL---AAEEERRRREAEERVQKSLAAEEEAARQRK-----AALEEVERLK-AKVEEARRL 1992
Query: 940 SDVGESEEEASIDLEDTGPMEDTASKREDGSEEA-ILGGEEPAKERKEVMRTETR-LSPF 997
+ E E + L ++ A KR E+A ++ +E ++ ++ E L
Sbjct: 1993 RERAEQESARQLQLA-----QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2047
Query: 998 TGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLA 1057
GEAEA+R E EE + E +E + V EAE ++ ++ A
Sbjct: 2048 RGEAEAARRAAEEA--EEARVQAE----REAAQSRRQVEEAERLKQSAEEQ--------A 2093
Query: 1058 RERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKA 1117
+ R +A+ LRK ++E+E RA A ++ A +++Q A + E E + E+T
Sbjct: 2094 QARAQAQAAAEKLRK-EAEQEAARRAQA--EQAALRQKQ---AADAEMEKHKKFAEQTLR 2147
Query: 1118 PPNEMGSDAENEAPVEASELSDNPGLLGED--SLKETVVPIFEATPGFEKSL-------E 1168
++ + ++ E LL E+ LK E+ L E
Sbjct: 2148 QKAQVEQEL-TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2206
Query: 1169 NITALRKEGGGE-RLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKV 1227
++ L+ E R RD ++ R E +K+ + ++AA EA ++
Sbjct: 2207 ELSKLKARIEAENRALILRDKDNTQR--FLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2264
Query: 1228 QAPEGLIPATGQAEELAAKDHDS---CAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEK 1284
A E L AE++ + + L+ AE +L+ Q+ +A+E ++
Sbjct: 2265 -AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE-------LLQQQKELAQEQARRLQE 2316
Query: 1285 FREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGD-------------MEGEGNTQ---- 1327
+E+ + EE + + TLE E + + + E + Q
Sbjct: 2317 DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2376
Query: 1328 ----------KNEGMGGGRVVAVEVLHGGGETAETAAEE-REVLAGSETAEEKTIANKAS 1376
+ E +V V+ L + ++ AE RE +A E +EK + +A
Sbjct: 2377 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK-LQQEAK 2435
Query: 1377 SFSDVAEEETWHQQDELVGKTAAAGKVVVEE 1407
+EE QQ++L+ +T A + + E
Sbjct: 2436 LLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2466
Score = 66.2 bits (160), Expect = 2e-10
Identities = 164/817 (20%), Positives = 333/817 (40%), Gaps = 119/817 (14%)
Query: 411 KSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVT 470
+S+++ E + + A + R+ RE E + K+ + + +A++ K L+EV
Sbjct: 1928 RSKEQAELEAARQRQLAAEEERRRREA------EERVQKSLAAEEEAARQRKAALEEV-- 1979
Query: 471 AVEEMTSKGKPGQEVLED-DQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQS 529
E + +K + + + E +QE+ + + ++ + EK++ A Q Q
Sbjct: 1980 --ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH--AFAVQQKEQELQQ 2035
Query: 530 PLDDKKDNLDPEK-ESETSSQKAPDARD-NVKDENDGCSESELEEDKQDMKTASSTSSRS 587
L ++ LD + E+E + + A +A + V+ E + E+ + +K ++ +++
Sbjct: 2036 TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2095
Query: 588 HPYSSDSEDE-SAVGDREAHTDSSTDESARRSSSQELSENDKPRK---SHLPIEESLEIE 643
+ + ++ ++EA + +++A R +E +K +K L + +E E
Sbjct: 2096 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2155
Query: 644 IEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSK 703
+ + + + + +DE + + E TE Q ++ E V EE K K++
Sbjct: 2156 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR-SQVEEELFSVRVQMEELSKLKAR 2214
Query: 704 LWEESTAQV-KDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQL 762
+ E+ A + +DK L+E + +A A ++ E A + E
Sbjct: 2215 IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA----RLSVAAQEAARLRQLAEEDLA 2270
Query: 763 VQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELA 822
Q+ L +K E+ +A Q + + K EA L + + + R + EQ +A
Sbjct: 2271 QQRA--LAEKMLKEKMQAVQ----EATRLKAEAELLQQQKELAQEQARRLQEDKEQ--MA 2322
Query: 823 EEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALM 882
++ E+ + G + EAE R+L + + E + L
Sbjct: 2323 QQLAEETQ-------GFQRTLEAERQRQL---------------------EMSAEAERLK 2354
Query: 883 LTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDV 942
L V E +A + E+ ++ +A + E LH E AT E+ + +
Sbjct: 2355 LRVAEMSRAQARAEEDAQR--FRKQAEEIG-EKLHRT----ELATQEKVTLVQTLEIQRQ 2407
Query: 943 GESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAE 1002
+S+ +A E +E K + ++ L EE ++E + ET+
Sbjct: 2408 -QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA-------- 2458
Query: 1003 ASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEM----VTEAEANREDDRKEILPKELDLAR 1058
+Q S S ++ L +E F+ +E + E++ V +A+ RE+ +++ E + R
Sbjct: 2459 ---LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2515
Query: 1059 -------ERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRA 1111
RR+ + +R+ E +++ + ++E +E Q+L+ + E + RA
Sbjct: 2516 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2575
Query: 1112 EEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENIT 1171
S+ + V A++ N G D+L P EA P E S +
Sbjct: 2576 A--------LAHSEEVTASQVAATKTLPN----GRDALDG---PAAEAEP--EHSFD--- 2615
Query: 1172 ALRKEGGGERLSEARDTEHKDREELSSRENRALKEGH 1208
LR++ +RL EA LS+ E + L +GH
Sbjct: 2616 GLRRKVSAQRLQEA--------GILSAEELQRLAQGH 2644
Score = 59.7 bits (143), Expect = 2e-08
Identities = 118/545 (21%), Positives = 215/545 (39%), Gaps = 61/545 (11%)
Query: 886 LETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGES 945
+E ++ +E ++ E+ LA AAL + A + A +E E + +
Sbjct: 1312 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1371
Query: 946 EEEASIDLED--TGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEA 1003
EEA++D + E+ R+ E + + +R E + + EA
Sbjct: 1372 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1431
Query: 1004 SRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKA 1063
+ Q E +L A E+ E ++ + EA R R+++ D ++ +R+A
Sbjct: 1432 TERQRGGAEGELQALRARA----EEAEAQKRQAQEEAERL--RRQV----QDESQRKRQA 1481
Query: 1064 ERPKTSLRKTDSE--REEVTRANALKDEDAFKEEQKLKAEEGE---TETEVRAEEETKAP 1118
E S K ++E RE+ AL EE +L+AEE E + EV + +
Sbjct: 1482 EVELASRVKAEAEAAREKQRALQAL-------EELRLQAEEAERRLRQAEVERARQVQVA 1534
Query: 1119 PNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGG 1178
AE E + + ++ L E SL+E V + + E+ + ++
Sbjct: 1535 LETAQRSAEAELQSKRASFAEKTAQL-ERSLQEEHVAVAQLREEAERRAQ------QQAE 1587
Query: 1179 GERLSEARDTEHKDREELSSRENRALK---EGHRQDGEGALAAPEAEPAGKVQAPEGLIP 1235
ER AR+ ++ E + N AL+ + + +LA EAE + + E
Sbjct: 1588 AER---AREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK--QKEEAEREAR 1642
Query: 1236 ATGQAEELAAKDHDSC-AGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDP 1294
G+AEE A + + LE + + G Q+ +A E ++ + E ++
Sbjct: 1643 RRGKAEEQAVRQRELAEQELEKQRQLAEGT-----AQQRLAAEQELIRLRAETEQGEQQR 1697
Query: 1295 EEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAA 1354
+ E++ L+ EA + + E + E + + A E T+E +
Sbjct: 1698 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE---ESRSTSEKSK 1754
Query: 1355 EEREVLAG------SETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEEL 1408
+ E AG E A + +A +A +AEE+ Q+ A A +V+ E+L
Sbjct: 1755 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR-------AEAERVLAEKL 1807
Query: 1409 ARSGE 1413
A GE
Sbjct: 1808 AAIGE 1812
Score = 51.2 bits (121), Expect = 8e-06
Identities = 106/492 (21%), Positives = 188/492 (38%), Gaps = 58/492 (11%)
Query: 1032 EEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDA 1091
EE AE R ++R+ + E++ A E+++ + K +ERE +++E
Sbjct: 1313 EEEERLAEQQRAEERERLA--EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1370
Query: 1092 FKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKE 1151
+EE + A++ + + ++ ++ S+AE +A +E ++ L E+ ++
Sbjct: 1371 RREEAAVDAQQQKRSIQEELQQLRQS------SEAEIQAKARQAEAAERSRLRIEEEIRV 1424
Query: 1152 TVVPIFEATP----GFEKSLENITALRKEGGGERLSEARDTEHKDRE------------- 1194
+ + EAT G E L+ + A +E ++ + E R+
Sbjct: 1425 VRLQL-EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1483
Query: 1195 ELSSR---ENRALKEGHR------------QDGEGALAAPEAEPAGKVQAPEGLIPATGQ 1239
EL+SR E A +E R ++ E L E E A +VQ + +
Sbjct: 1484 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1543
Query: 1240 AE--ELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEE 1297
AE A + A LE + + LR + + AE+ REEA E +
Sbjct: 1544 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1603
Query: 1298 EDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEER 1357
L + ++ + E QK E A G+ E A +R
Sbjct: 1604 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE--------AEREARRRGKAEEQAVRQR 1655
Query: 1358 EVLAGSETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEELARSGEEVPA 1417
E LA E +++ +A + AE+E + E + +++ EELAR E A
Sbjct: 1656 E-LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE-TEQGEQQRQLLEEELARLQREAAA 1713
Query: 1418 AEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEG---SEGQEAATGSGDGRQETGAAEKF 1474
A + E +E + + +EE SE + + GR A E
Sbjct: 1714 ATQKRQELEAEL-AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA 1772
Query: 1475 RL-GLSREGERE 1485
RL L+ E +R+
Sbjct: 1773 RLRALAEEAKRQ 1784
Score = 39.7 bits (91), Expect = 0.023
Identities = 154/756 (20%), Positives = 270/756 (35%), Gaps = 113/756 (14%)
Query: 800 EAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAEG----AAEAEGVRRLGEGG 855
E VH L K A E A+ E+++ +E +G +AEAE V L E
Sbjct: 968 ETRTVHRLRLPLDKEPAR--ECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1025
Query: 856 -SDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANE------- 907
+ P ++ + +G ++ A+ L L+T G QG E+ + A+E
Sbjct: 1026 PAAPTLRSELELTLG-KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ 1084
Query: 908 AAALNLEHLHEV-AALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKR 966
A L L A+L++ E + A+ D +E L+ D +R
Sbjct: 1085 AVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1144
Query: 967 --EDGSE-----EAILGGEEPAKERKEVMRTETR--------LSPFTGEAEASRMQV--- 1008
E ++ +A+L + + E + + R L + +A + Q+
Sbjct: 1145 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1204
Query: 1009 --SEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERP 1066
++ L +E L +E E V E + + I EL L + + E
Sbjct: 1205 PLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV 1264
Query: 1067 KTSLRK------TDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPN 1120
+ +K ++S +E E Q +K +ET R EEE +
Sbjct: 1265 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI---SETLRRMEEEERLAEQ 1321
Query: 1121 EMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGE 1180
+ + E A VEA+ EK + + +
Sbjct: 1322 QRAEERERLAEVEAA---------------------------LEKQ-RQLAEAHAQAKAQ 1353
Query: 1181 RLSEARDTEHKDREELSSRENRAL-----KEGHRQDGEGALAAPEAEPAGKVQAPEGLIP 1235
EA++ + + +EE+ RE A+ K +++ + + EAE K + E
Sbjct: 1354 AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1413
Query: 1236 ATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEA--VDED 1293
+ + EE + LE +GG + L+ A AEE + +EEA +
Sbjct: 1414 SRLRIEE---EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1470
Query: 1294 PEEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETA 1353
++E ++ E E +E + E + Q A+E L E AE
Sbjct: 1471 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQ-----------ALEELRLQAEEAERR 1519
Query: 1354 AEE------REVLAGSETAE---EKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVV 1404
+ R+V ETA+ E + +K +SF++ + Q+E V A +
Sbjct: 1520 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV--AVAQLREE 1577
Query: 1405 VEELARSGEEVPAAEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEGSEGQEAATGSGDG 1464
E A+ E A E + AL L + EE ++ + A +
Sbjct: 1578 AERRAQQQAEAERAREEAERELERWQLKANEALR-----LRLQAEEVAQQKSLAQAEAEK 1632
Query: 1465 RQETGAAEKFRLGLSRE---GERELSPESLQAMATL 1497
++E E R G + E +REL+ + L+ L
Sbjct: 1633 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1668
Score = 37.7 bits (86), Expect = 0.086
Identities = 49/210 (23%), Positives = 82/210 (39%), Gaps = 23/210 (10%)
Query: 457 SAQEIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQG----EK 512
SA+ TG K+ + + +L+D L+ + +D E+ E
Sbjct: 3974 SAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEV 4033
Query: 513 SNEEGQADVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEE 572
+ + G D +MN I P DD K DP E + + + + D G L+E
Sbjct: 4034 AYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMER--CITDPQTGLCLLPLKE 4091
Query: 573 DKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKS 632
K++ KT+S +S R + D E + S E+ R+ ++
Sbjct: 4092 KKRERKTSSKSSVRKR--------RVVIVDPETGKEMSVYEAYRKGLID--------HQT 4135
Query: 633 HLPIEESLEIEIEDQEITKADVETKPMPID 662
+L + E E E E+ I+ +D K M ID
Sbjct: 4136 YLELSEQ-ECEWEEITISSSDGVVKSMIID 4164
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 80.9 bits (198), Expect = 9e-15
Identities = 222/1041 (21%), Positives = 391/1041 (37%), Gaps = 140/1041 (13%)
Query: 417 STEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQ-EIKTG----LKEVVTA 471
+T+K +EL+ KVR E E ++ + +E S S K + E + G L E
Sbjct: 1883 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1942
Query: 472 VEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPL 531
+ + + K +++ E+D + E E GE + + +A++ +
Sbjct: 1943 LRALAEEAKRQRQLAEEDAARQ-RAEAERVLAEKLAAIGEATRLKTEAEIALK------- 1994
Query: 532 DDKKDNLDPEKESETSSQKAPDARDNVK--DENDGCSESELEEDKQDMKTAS-STSSRSH 588
+ E E+E + A D + +E ++++EE ++ AS S R
Sbjct: 1995 -------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 2047
Query: 589 PYSSDSEDESAVGDREAHTDSSTDESARRSSSQ---ELSENDKPRKSHLPIEESLEIEIE 645
D+ + + E ++ E A ++ EL + L +E E+E
Sbjct: 2048 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 2107
Query: 646 DQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSKLW 705
Q A+ E + +E + L E Q A L E EE + + +
Sbjct: 2108 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA-ALEEVERLKAKVEEARRLRERAE 2166
Query: 706 EESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQK 765
+ES Q++ LA A +E A + ++ +Q +Q+
Sbjct: 2167 QESARQLQ----------------------LAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2204
Query: 766 TYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEF 825
TL++++++ D ++G+ EAA A EA ++A + A+ EE
Sbjct: 2205 --TLQQEQSV----------LDQLRGEAEAAR-RAAEEAEEARVQAEREAAQSRRQVEE- 2250
Query: 826 TEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTV 885
ER + A E R + ++ + + A ++A ++ E +
Sbjct: 2251 ---------AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2301
Query: 886 LETDKAASEGEQGL-EKAVLANEAAALNL---EHLHEVAALREAATSEEGEA-EGGVAVS 940
E +K EQ L +KA + E L L E H+ L E + EA E S
Sbjct: 2302 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2361
Query: 941 DVGESEEEASIDLEDTGPMEDTASK-------REDGSEEAILGGEEPAKERKEVMRTETR 993
V E + +E+ ++ R+ + + L +E A++ K+V R
Sbjct: 2362 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL--QEEAEKMKQVAEEAAR 2419
Query: 994 LSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKE 1053
LS EA R E ++ +LA E + E+M EA R E+L ++
Sbjct: 2420 LSVAAQEAARLRQLAEEDLAQQRALA-------EKMLKEKMQAVQEATRLKAEAELLQQQ 2472
Query: 1054 LDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAE- 1112
+LA+E+ R+ ++E++ + A E+ ++ L+AE + + E+ AE
Sbjct: 2473 KELAQEQ---------ARRLQEDKEQMAQQLA---EETQGFQRTLEAER-QRQLEMSAEA 2519
Query: 1113 EETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITA 1172
E K EM S A+ A +A +GE + + + T ++LE I
Sbjct: 2520 ERLKLRVAEM-SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT--LVQTLE-IQR 2575
Query: 1173 LRKEGGGERLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKVQAPEG 1232
+ + ERL EA +++E+L E L ++E VQ E
Sbjct: 2576 QQSDHDAERLREAIAELEREKEKLQQ--------------EAKLLQLKSEEMQTVQ-QEQ 2620
Query: 1233 LIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDE 1292
L+ T ++ + DS E E Q + Q+ VA+ + E+ R++ E
Sbjct: 2621 LLQETQALQQSFLSEKDSLLQRERFIE-QEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2679
Query: 1293 DPEE------EEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGG 1346
+ EE + E E R E +E + Q+ E + E L
Sbjct: 2680 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE-QQRRQQEELLAEENQRLREQLQLL 2738
Query: 1347 GETAETAAEEREVLAGSETAEEKTIANKASSF-SDVAEEETWHQQDELVGKTAA-----A 1400
E A E + S+ A KT+ N + AE E H D L K +A A
Sbjct: 2739 EEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEA 2798
Query: 1401 GKVVVEELARSGEEVPAAEEM 1421
G + EEL R + +E+
Sbjct: 2799 GILSAEELQRLAQGHTTVDEL 2819
Score = 72.0 bits (175), Expect = 4e-12
Identities = 212/1051 (20%), Positives = 408/1051 (38%), Gaps = 140/1051 (13%)
Query: 414 KEKSTEKGEELK-KAEGKVRKEREYVIPKRNEIKENKTSV--SAKFSAQEIKTGLKEVVT 470
K+++ + EEL+ +AE R+ R+ + + +++ + SA+ Q + E
Sbjct: 1668 KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA 1727
Query: 471 AVEEMTSKGKPGQEVLEDDQENTLKYEYE-----EDFEVDEEKQGEKSNEEGQADVQMNG 525
+E + L ++ E + + E E+ E + E+ K+NE + +Q
Sbjct: 1728 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1787
Query: 526 IPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSS 585
+ Q + EK+ E + + +AR K E + EL E + + + + +
Sbjct: 1788 VAQQK---SLAQAEAEKQKEEAER---EARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1841
Query: 586 RSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIE 645
+++ E ++ E R+ +EL+ + + + LE E+
Sbjct: 1842 AQQRLAAEQELI------RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1895
Query: 646 DQEITKADVETKPMPIDESFENVLKEGTEKGTQEI-AEG-----LSEKSGKHVSAEEKEK 699
+A++E + E + +EK Q + AE L+E++ + + E+ K
Sbjct: 1896 K---VRAEMEVL-LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1951
Query: 700 DKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKES 759
+ +L EE A+ + + + + A+G T E A E+
Sbjct: 1952 RQRQLAEEDAAR-----------QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 2000
Query: 760 QQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQP 819
++L + + E++A QH+ ADI + + ++ + L + T Q
Sbjct: 2001 ERLRRLAEDEAFQRRRLEEQAAQHK-ADIEERLAQLRKASDSELERQKGLV--EDTLRQR 2057
Query: 820 ELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQ 879
EE E + E+ A G AE E LG S+ +K+ L EA ++
Sbjct: 2058 RQVEE--EILALKASFEKAAAGKAELE--LELGRIRSNAEDTLRSKEQAEL---EAARQR 2110
Query: 880 ALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAV 939
L E ++ E E+ ++K++ A E AA + AAL E + + E +
Sbjct: 2111 QL---AAEEERRRREAEERVQKSLAAEEEAARQRK-----AALEEVERLK-AKVEEARRL 2161
Query: 940 SDVGESEEEASIDLEDTGPMEDTASKREDGSEEA-ILGGEEPAKERKEVMRTETR-LSPF 997
+ E E + L ++ A KR E+A ++ +E ++ ++ E L
Sbjct: 2162 RERAEQESARQLQLA-----QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2216
Query: 998 TGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLA 1057
GEAEA+R E EE + E +E + V EAE ++ ++ A
Sbjct: 2217 RGEAEAARRAAEEA--EEARVQAE----REAAQSRRQVEEAERLKQSAEEQ--------A 2262
Query: 1058 RERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKA 1117
+ R +A+ LRK ++E+E RA A ++ A +++Q A + E E + E+T
Sbjct: 2263 QARAQAQAAAEKLRK-EAEQEAARRAQA--EQAALRQKQ---AADAEMEKHKKFAEQTLR 2316
Query: 1118 PPNEMGSDAENEAPVEASELSDNPGLLGED--SLKETVVPIFEATPGFEKSL-------E 1168
++ + ++ E LL E+ LK E+ L E
Sbjct: 2317 QKAQVEQEL-TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2375
Query: 1169 NITALRKEGGGE-RLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKV 1227
++ L+ E R RD ++ R E +K+ + ++AA EA ++
Sbjct: 2376 ELSKLKARIEAENRALILRDKDNTQR--FLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2433
Query: 1228 QAPEGLIPATGQAEELAAKDHDS---CAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEK 1284
A E L AE++ + + L+ AE +L+ Q+ +A+E ++
Sbjct: 2434 -AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE-------LLQQQKELAQEQARRLQE 2485
Query: 1285 FREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGD-------------MEGEGNTQ---- 1327
+E+ + EE + + TLE E + + + E + Q
Sbjct: 2486 DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2545
Query: 1328 ----------KNEGMGGGRVVAVEVLHGGGETAETAAEE-REVLAGSETAEEKTIANKAS 1376
+ E +V V+ L + ++ AE RE +A E +EK + +A
Sbjct: 2546 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK-LQQEAK 2604
Query: 1377 SFSDVAEEETWHQQDELVGKTAAAGKVVVEE 1407
+EE QQ++L+ +T A + + E
Sbjct: 2605 LLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2635
Score = 66.2 bits (160), Expect = 2e-10
Identities = 164/817 (20%), Positives = 333/817 (40%), Gaps = 119/817 (14%)
Query: 411 KSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVT 470
+S+++ E + + A + R+ RE E + K+ + + +A++ K L+EV
Sbjct: 2097 RSKEQAELEAARQRQLAAEEERRRREA------EERVQKSLAAEEEAARQRKAALEEV-- 2148
Query: 471 AVEEMTSKGKPGQEVLED-DQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQS 529
E + +K + + + E +QE+ + + ++ + EK++ A Q Q
Sbjct: 2149 --ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH--AFAVQQKEQELQQ 2204
Query: 530 PLDDKKDNLDPEK-ESETSSQKAPDARD-NVKDENDGCSESELEEDKQDMKTASSTSSRS 587
L ++ LD + E+E + + A +A + V+ E + E+ + +K ++ +++
Sbjct: 2205 TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2264
Query: 588 HPYSSDSEDE-SAVGDREAHTDSSTDESARRSSSQELSENDKPRK---SHLPIEESLEIE 643
+ + ++ ++EA + +++A R +E +K +K L + +E E
Sbjct: 2265 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2324
Query: 644 IEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSK 703
+ + + + + +DE + + E TE Q ++ E V EE K K++
Sbjct: 2325 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR-SQVEEELFSVRVQMEELSKLKAR 2383
Query: 704 LWEESTAQV-KDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQL 762
+ E+ A + +DK L+E + +A A ++ E A + E
Sbjct: 2384 IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA----RLSVAAQEAARLRQLAEEDLA 2439
Query: 763 VQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELA 822
Q+ L +K E+ +A Q + + K EA L + + + R + EQ +A
Sbjct: 2440 QQRA--LAEKMLKEKMQAVQ----EATRLKAEAELLQQQKELAQEQARRLQEDKEQ--MA 2491
Query: 823 EEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALM 882
++ E+ + G + EAE R+L + + E + L
Sbjct: 2492 QQLAEETQ-------GFQRTLEAERQRQL---------------------EMSAEAERLK 2523
Query: 883 LTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDV 942
L V E +A + E+ ++ +A + E LH E AT E+ + +
Sbjct: 2524 LRVAEMSRAQARAEEDAQR--FRKQAEEIG-EKLHRT----ELATQEKVTLVQTLEIQRQ 2576
Query: 943 GESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAE 1002
+S+ +A E +E K + ++ L EE ++E + ET+
Sbjct: 2577 -QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA-------- 2627
Query: 1003 ASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEM----VTEAEANREDDRKEILPKELDLAR 1058
+Q S S ++ L +E F+ +E + E++ V +A+ RE+ +++ E + R
Sbjct: 2628 ---LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2684
Query: 1059 -------ERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRA 1111
RR+ + +R+ E +++ + ++E +E Q+L+ + E + RA
Sbjct: 2685 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2744
Query: 1112 EEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENIT 1171
S+ + V A++ N G D+L P EA P E S +
Sbjct: 2745 A--------LAHSEEVTASQVAATKTLPN----GRDALDG---PAAEAEP--EHSFD--- 2784
Query: 1172 ALRKEGGGERLSEARDTEHKDREELSSRENRALKEGH 1208
LR++ +RL EA LS+ E + L +GH
Sbjct: 2785 GLRRKVSAQRLQEA--------GILSAEELQRLAQGH 2813
Score = 59.7 bits (143), Expect = 2e-08
Identities = 118/545 (21%), Positives = 215/545 (39%), Gaps = 61/545 (11%)
Query: 886 LETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGES 945
+E ++ +E ++ E+ LA AAL + A + A +E E + +
Sbjct: 1481 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1540
Query: 946 EEEASIDLED--TGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEA 1003
EEA++D + E+ R+ E + + +R E + + EA
Sbjct: 1541 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1600
Query: 1004 SRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKA 1063
+ Q E +L A E+ E ++ + EA R R+++ D ++ +R+A
Sbjct: 1601 TERQRGGAEGELQALRARA----EEAEAQKRQAQEEAERL--RRQV----QDESQRKRQA 1650
Query: 1064 ERPKTSLRKTDSE--REEVTRANALKDEDAFKEEQKLKAEEGE---TETEVRAEEETKAP 1118
E S K ++E RE+ AL EE +L+AEE E + EV + +
Sbjct: 1651 EVELASRVKAEAEAAREKQRALQAL-------EELRLQAEEAERRLRQAEVERARQVQVA 1703
Query: 1119 PNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGG 1178
AE E + + ++ L E SL+E V + + E+ + ++
Sbjct: 1704 LETAQRSAEAELQSKRASFAEKTAQL-ERSLQEEHVAVAQLREEAERRAQ------QQAE 1756
Query: 1179 GERLSEARDTEHKDREELSSRENRALK---EGHRQDGEGALAAPEAEPAGKVQAPEGLIP 1235
ER AR+ ++ E + N AL+ + + +LA EAE + + E
Sbjct: 1757 AER---AREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK--QKEEAEREAR 1811
Query: 1236 ATGQAEELAAKDHDSC-AGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDP 1294
G+AEE A + + LE + + G Q+ +A E ++ + E ++
Sbjct: 1812 RRGKAEEQAVRQRELAEQELEKQRQLAEGT-----AQQRLAAEQELIRLRAETEQGEQQR 1866
Query: 1295 EEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAA 1354
+ E++ L+ EA + + E + E + + A E T+E +
Sbjct: 1867 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE---ESRSTSEKSK 1923
Query: 1355 EEREVLAG------SETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEEL 1408
+ E AG E A + +A +A +AEE+ Q+ A A +V+ E+L
Sbjct: 1924 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR-------AEAERVLAEKL 1976
Query: 1409 ARSGE 1413
A GE
Sbjct: 1977 AAIGE 1981
Score = 51.2 bits (121), Expect = 8e-06
Identities = 106/492 (21%), Positives = 188/492 (38%), Gaps = 58/492 (11%)
Query: 1032 EEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDA 1091
EE AE R ++R+ + E++ A E+++ + K +ERE +++E
Sbjct: 1482 EEEERLAEQQRAEERERLA--EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1539
Query: 1092 FKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKE 1151
+EE + A++ + + ++ ++ S+AE +A +E ++ L E+ ++
Sbjct: 1540 RREEAAVDAQQQKRSIQEELQQLRQS------SEAEIQAKARQAEAAERSRLRIEEEIRV 1593
Query: 1152 TVVPIFEATP----GFEKSLENITALRKEGGGERLSEARDTEHKDRE------------- 1194
+ + EAT G E L+ + A +E ++ + E R+
Sbjct: 1594 VRLQL-EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1652
Query: 1195 ELSSR---ENRALKEGHR------------QDGEGALAAPEAEPAGKVQAPEGLIPATGQ 1239
EL+SR E A +E R ++ E L E E A +VQ + +
Sbjct: 1653 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1712
Query: 1240 AE--ELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEE 1297
AE A + A LE + + LR + + AE+ REEA E +
Sbjct: 1713 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1772
Query: 1298 EDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEER 1357
L + ++ + E QK E A G+ E A +R
Sbjct: 1773 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE--------AEREARRRGKAEEQAVRQR 1824
Query: 1358 EVLAGSETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEELARSGEEVPA 1417
E LA E +++ +A + AE+E + E + +++ EELAR E A
Sbjct: 1825 E-LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE-TEQGEQQRQLLEEELARLQREAAA 1882
Query: 1418 AEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEG---SEGQEAATGSGDGRQETGAAEKF 1474
A + E +E + + +EE SE + + GR A E
Sbjct: 1883 ATQKRQELEAEL-AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA 1941
Query: 1475 RL-GLSREGERE 1485
RL L+ E +R+
Sbjct: 1942 RLRALAEEAKRQ 1953
Score = 39.7 bits (91), Expect = 0.023
Identities = 154/756 (20%), Positives = 270/756 (35%), Gaps = 113/756 (14%)
Query: 800 EAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAEG----AAEAEGVRRLGEGG 855
E VH L K A E A+ E+++ +E +G +AEAE V L E
Sbjct: 1137 ETRTVHRLRLPLDKEPAR--ECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1194
Query: 856 -SDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANE------- 907
+ P ++ + +G ++ A+ L L+T G QG E+ + A+E
Sbjct: 1195 PAAPTLRSELELTLG-KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ 1253
Query: 908 AAALNLEHLHEV-AALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKR 966
A L L A+L++ E + A+ D +E L+ D +R
Sbjct: 1254 AVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1313
Query: 967 --EDGSE-----EAILGGEEPAKERKEVMRTETR--------LSPFTGEAEASRMQV--- 1008
E ++ +A+L + + E + + R L + +A + Q+
Sbjct: 1314 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1373
Query: 1009 --SEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERP 1066
++ L +E L +E E V E + + I EL L + + E
Sbjct: 1374 PLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV 1433
Query: 1067 KTSLRK------TDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPN 1120
+ +K ++S +E E Q +K +ET R EEE +
Sbjct: 1434 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI---SETLRRMEEEERLAEQ 1490
Query: 1121 EMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGE 1180
+ + E A VEA+ EK + + +
Sbjct: 1491 QRAEERERLAEVEAA---------------------------LEKQ-RQLAEAHAQAKAQ 1522
Query: 1181 RLSEARDTEHKDREELSSRENRAL-----KEGHRQDGEGALAAPEAEPAGKVQAPEGLIP 1235
EA++ + + +EE+ RE A+ K +++ + + EAE K + E
Sbjct: 1523 AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1582
Query: 1236 ATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEA--VDED 1293
+ + EE + LE +GG + L+ A AEE + +EEA +
Sbjct: 1583 SRLRIEE---EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1639
Query: 1294 PEEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETA 1353
++E ++ E E +E + E + Q A+E L E AE
Sbjct: 1640 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQ-----------ALEELRLQAEEAERR 1688
Query: 1354 AEE------REVLAGSETAE---EKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVV 1404
+ R+V ETA+ E + +K +SF++ + Q+E V A +
Sbjct: 1689 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV--AVAQLREE 1746
Query: 1405 VEELARSGEEVPAAEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEGSEGQEAATGSGDG 1464
E A+ E A E + AL L + EE ++ + A +
Sbjct: 1747 AERRAQQQAEAERAREEAERELERWQLKANEALR-----LRLQAEEVAQQKSLAQAEAEK 1801
Query: 1465 RQETGAAEKFRLGLSRE---GERELSPESLQAMATL 1497
++E E R G + E +REL+ + L+ L
Sbjct: 1802 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1837
Score = 37.7 bits (86), Expect = 0.086
Identities = 49/210 (23%), Positives = 82/210 (39%), Gaps = 23/210 (10%)
Query: 457 SAQEIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQG----EK 512
SA+ TG K+ + + +L+D L+ + +D E+ E
Sbjct: 4143 SAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEV 4202
Query: 513 SNEEGQADVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEE 572
+ + G D +MN I P DD K DP E + + + + D G L+E
Sbjct: 4203 AYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMER--CITDPQTGLCLLPLKE 4260
Query: 573 DKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKS 632
K++ KT+S +S R + D E + S E+ R+ ++
Sbjct: 4261 KKRERKTSSKSSVRKR--------RVVIVDPETGKEMSVYEAYRKGLID--------HQT 4304
Query: 633 HLPIEESLEIEIEDQEITKADVETKPMPID 662
+L + E E E E+ I+ +D K M ID
Sbjct: 4305 YLELSEQ-ECEWEEITISSSDGVVKSMIID 4333
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 80.9 bits (198), Expect = 9e-15
Identities = 222/1041 (21%), Positives = 391/1041 (37%), Gaps = 140/1041 (13%)
Query: 417 STEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQ-EIKTG----LKEVVTA 471
+T+K +EL+ KVR E E ++ + +E S S K + E + G L E
Sbjct: 1724 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1783
Query: 472 VEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPL 531
+ + + K +++ E+D + E E GE + + +A++ +
Sbjct: 1784 LRALAEEAKRQRQLAEEDAARQ-RAEAERVLAEKLAAIGEATRLKTEAEIALK------- 1835
Query: 532 DDKKDNLDPEKESETSSQKAPDARDNVK--DENDGCSESELEEDKQDMKTAS-STSSRSH 588
+ E E+E + A D + +E ++++EE ++ AS S R
Sbjct: 1836 -------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1888
Query: 589 PYSSDSEDESAVGDREAHTDSSTDESARRSSSQ---ELSENDKPRKSHLPIEESLEIEIE 645
D+ + + E ++ E A ++ EL + L +E E+E
Sbjct: 1889 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1948
Query: 646 DQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSKLW 705
Q A+ E + +E + L E Q A L E EE + + +
Sbjct: 1949 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA-ALEEVERLKAKVEEARRLRERAE 2007
Query: 706 EESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQK 765
+ES Q++ LA A +E A + ++ +Q +Q+
Sbjct: 2008 QESARQLQ----------------------LAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2045
Query: 766 TYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEF 825
TL++++++ D ++G+ EAA A EA ++A + A+ EE
Sbjct: 2046 --TLQQEQSV----------LDQLRGEAEAAR-RAAEEAEEARVQAEREAAQSRRQVEE- 2091
Query: 826 TEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTV 885
ER + A E R + ++ + + A ++A ++ E +
Sbjct: 2092 ---------AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2142
Query: 886 LETDKAASEGEQGL-EKAVLANEAAALNL---EHLHEVAALREAATSEEGEA-EGGVAVS 940
E +K EQ L +KA + E L L E H+ L E + EA E S
Sbjct: 2143 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2202
Query: 941 DVGESEEEASIDLEDTGPMEDTASK-------REDGSEEAILGGEEPAKERKEVMRTETR 993
V E + +E+ ++ R+ + + L +E A++ K+V R
Sbjct: 2203 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL--QEEAEKMKQVAEEAAR 2260
Query: 994 LSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKE 1053
LS EA R E ++ +LA E + E+M EA R E+L ++
Sbjct: 2261 LSVAAQEAARLRQLAEEDLAQQRALA-------EKMLKEKMQAVQEATRLKAEAELLQQQ 2313
Query: 1054 LDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAE- 1112
+LA+E+ R+ ++E++ + A E+ ++ L+AE + + E+ AE
Sbjct: 2314 KELAQEQ---------ARRLQEDKEQMAQQLA---EETQGFQRTLEAER-QRQLEMSAEA 2360
Query: 1113 EETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITA 1172
E K EM S A+ A +A +GE + + + T ++LE I
Sbjct: 2361 ERLKLRVAEM-SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT--LVQTLE-IQR 2416
Query: 1173 LRKEGGGERLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKVQAPEG 1232
+ + ERL EA +++E+L E L ++E VQ E
Sbjct: 2417 QQSDHDAERLREAIAELEREKEKLQQ--------------EAKLLQLKSEEMQTVQ-QEQ 2461
Query: 1233 LIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDE 1292
L+ T ++ + DS E E Q + Q+ VA+ + E+ R++ E
Sbjct: 2462 LLQETQALQQSFLSEKDSLLQRERFIE-QEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2520
Query: 1293 DPEE------EEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGG 1346
+ EE + E E R E +E + Q+ E + E L
Sbjct: 2521 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE-QQRRQQEELLAEENQRLREQLQLL 2579
Query: 1347 GETAETAAEEREVLAGSETAEEKTIANKASSF-SDVAEEETWHQQDELVGKTAA-----A 1400
E A E + S+ A KT+ N + AE E H D L K +A A
Sbjct: 2580 EEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEA 2639
Query: 1401 GKVVVEELARSGEEVPAAEEM 1421
G + EEL R + +E+
Sbjct: 2640 GILSAEELQRLAQGHTTVDEL 2660
Score = 72.0 bits (175), Expect = 4e-12
Identities = 212/1051 (20%), Positives = 408/1051 (38%), Gaps = 140/1051 (13%)
Query: 414 KEKSTEKGEELK-KAEGKVRKEREYVIPKRNEIKENKTSV--SAKFSAQEIKTGLKEVVT 470
K+++ + EEL+ +AE R+ R+ + + +++ + SA+ Q + E
Sbjct: 1509 KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA 1568
Query: 471 AVEEMTSKGKPGQEVLEDDQENTLKYEYE-----EDFEVDEEKQGEKSNEEGQADVQMNG 525
+E + L ++ E + + E E+ E + E+ K+NE + +Q
Sbjct: 1569 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1628
Query: 526 IPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSS 585
+ Q + EK+ E + + +AR K E + EL E + + + + +
Sbjct: 1629 VAQQK---SLAQAEAEKQKEEAER---EARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1682
Query: 586 RSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIE 645
+++ E ++ E R+ +EL+ + + + LE E+
Sbjct: 1683 AQQRLAAEQELI------RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1736
Query: 646 DQEITKADVETKPMPIDESFENVLKEGTEKGTQEI-AEG-----LSEKSGKHVSAEEKEK 699
+A++E + E + +EK Q + AE L+E++ + + E+ K
Sbjct: 1737 K---VRAEMEVL-LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1792
Query: 700 DKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKES 759
+ +L EE A+ + + + + A+G T E A E+
Sbjct: 1793 RQRQLAEEDAAR-----------QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1841
Query: 760 QQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQP 819
++L + + E++A QH+ ADI + + ++ + L + T Q
Sbjct: 1842 ERLRRLAEDEAFQRRRLEEQAAQHK-ADIEERLAQLRKASDSELERQKGLV--EDTLRQR 1898
Query: 820 ELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQ 879
EE E + E+ A G AE E LG S+ +K+ L EA ++
Sbjct: 1899 RQVEE--EILALKASFEKAAAGKAELE--LELGRIRSNAEDTLRSKEQAEL---EAARQR 1951
Query: 880 ALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAV 939
L E ++ E E+ ++K++ A E AA + AAL E + + E +
Sbjct: 1952 QL---AAEEERRRREAEERVQKSLAAEEEAARQRK-----AALEEVERLK-AKVEEARRL 2002
Query: 940 SDVGESEEEASIDLEDTGPMEDTASKREDGSEEA-ILGGEEPAKERKEVMRTETR-LSPF 997
+ E E + L ++ A KR E+A ++ +E ++ ++ E L
Sbjct: 2003 RERAEQESARQLQLA-----QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2057
Query: 998 TGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLA 1057
GEAEA+R E EE + E +E + V EAE ++ ++ A
Sbjct: 2058 RGEAEAARRAAEEA--EEARVQAE----REAAQSRRQVEEAERLKQSAEEQ--------A 2103
Query: 1058 RERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKA 1117
+ R +A+ LRK ++E+E RA A ++ A +++Q A + E E + E+T
Sbjct: 2104 QARAQAQAAAEKLRK-EAEQEAARRAQA--EQAALRQKQ---AADAEMEKHKKFAEQTLR 2157
Query: 1118 PPNEMGSDAENEAPVEASELSDNPGLLGED--SLKETVVPIFEATPGFEKSL-------E 1168
++ + ++ E LL E+ LK E+ L E
Sbjct: 2158 QKAQVEQEL-TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2216
Query: 1169 NITALRKEGGGE-RLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKV 1227
++ L+ E R RD ++ R E +K+ + ++AA EA ++
Sbjct: 2217 ELSKLKARIEAENRALILRDKDNTQR--FLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2274
Query: 1228 QAPEGLIPATGQAEELAAKDHDS---CAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEK 1284
A E L AE++ + + L+ AE +L+ Q+ +A+E ++
Sbjct: 2275 -AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE-------LLQQQKELAQEQARRLQE 2326
Query: 1285 FREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGD-------------MEGEGNTQ---- 1327
+E+ + EE + + TLE E + + + E + Q
Sbjct: 2327 DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2386
Query: 1328 ----------KNEGMGGGRVVAVEVLHGGGETAETAAEE-REVLAGSETAEEKTIANKAS 1376
+ E +V V+ L + ++ AE RE +A E +EK + +A
Sbjct: 2387 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK-LQQEAK 2445
Query: 1377 SFSDVAEEETWHQQDELVGKTAAAGKVVVEE 1407
+EE QQ++L+ +T A + + E
Sbjct: 2446 LLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2476
Score = 66.2 bits (160), Expect = 2e-10
Identities = 164/817 (20%), Positives = 333/817 (40%), Gaps = 119/817 (14%)
Query: 411 KSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVT 470
+S+++ E + + A + R+ RE E + K+ + + +A++ K L+EV
Sbjct: 1938 RSKEQAELEAARQRQLAAEEERRRREA------EERVQKSLAAEEEAARQRKAALEEV-- 1989
Query: 471 AVEEMTSKGKPGQEVLED-DQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQS 529
E + +K + + + E +QE+ + + ++ + EK++ A Q Q
Sbjct: 1990 --ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH--AFAVQQKEQELQQ 2045
Query: 530 PLDDKKDNLDPEK-ESETSSQKAPDARD-NVKDENDGCSESELEEDKQDMKTASSTSSRS 587
L ++ LD + E+E + + A +A + V+ E + E+ + +K ++ +++
Sbjct: 2046 TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2105
Query: 588 HPYSSDSEDE-SAVGDREAHTDSSTDESARRSSSQELSENDKPRK---SHLPIEESLEIE 643
+ + ++ ++EA + +++A R +E +K +K L + +E E
Sbjct: 2106 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2165
Query: 644 IEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSK 703
+ + + + + +DE + + E TE Q ++ E V EE K K++
Sbjct: 2166 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR-SQVEEELFSVRVQMEELSKLKAR 2224
Query: 704 LWEESTAQV-KDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQL 762
+ E+ A + +DK L+E + +A A ++ E A + E
Sbjct: 2225 IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA----RLSVAAQEAARLRQLAEEDLA 2280
Query: 763 VQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELA 822
Q+ L +K E+ +A Q + + K EA L + + + R + EQ +A
Sbjct: 2281 QQRA--LAEKMLKEKMQAVQ----EATRLKAEAELLQQQKELAQEQARRLQEDKEQ--MA 2332
Query: 823 EEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALM 882
++ E+ + G + EAE R+L + + E + L
Sbjct: 2333 QQLAEETQ-------GFQRTLEAERQRQL---------------------EMSAEAERLK 2364
Query: 883 LTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDV 942
L V E +A + E+ ++ +A + E LH E AT E+ + +
Sbjct: 2365 LRVAEMSRAQARAEEDAQR--FRKQAEEIG-EKLHRT----ELATQEKVTLVQTLEIQRQ 2417
Query: 943 GESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAE 1002
+S+ +A E +E K + ++ L EE ++E + ET+
Sbjct: 2418 -QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA-------- 2468
Query: 1003 ASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEM----VTEAEANREDDRKEILPKELDLAR 1058
+Q S S ++ L +E F+ +E + E++ V +A+ RE+ +++ E + R
Sbjct: 2469 ---LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2525
Query: 1059 -------ERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRA 1111
RR+ + +R+ E +++ + ++E +E Q+L+ + E + RA
Sbjct: 2526 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2585
Query: 1112 EEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENIT 1171
S+ + V A++ N G D+L P EA P E S +
Sbjct: 2586 A--------LAHSEEVTASQVAATKTLPN----GRDALDG---PAAEAEP--EHSFD--- 2625
Query: 1172 ALRKEGGGERLSEARDTEHKDREELSSRENRALKEGH 1208
LR++ +RL EA LS+ E + L +GH
Sbjct: 2626 GLRRKVSAQRLQEA--------GILSAEELQRLAQGH 2654
Score = 59.7 bits (143), Expect = 2e-08
Identities = 118/545 (21%), Positives = 215/545 (39%), Gaps = 61/545 (11%)
Query: 886 LETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGES 945
+E ++ +E ++ E+ LA AAL + A + A +E E + +
Sbjct: 1322 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1381
Query: 946 EEEASIDLED--TGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEA 1003
EEA++D + E+ R+ E + + +R E + + EA
Sbjct: 1382 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1441
Query: 1004 SRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKA 1063
+ Q E +L A E+ E ++ + EA R R+++ D ++ +R+A
Sbjct: 1442 TERQRGGAEGELQALRARA----EEAEAQKRQAQEEAERL--RRQV----QDESQRKRQA 1491
Query: 1064 ERPKTSLRKTDSE--REEVTRANALKDEDAFKEEQKLKAEEGE---TETEVRAEEETKAP 1118
E S K ++E RE+ AL EE +L+AEE E + EV + +
Sbjct: 1492 EVELASRVKAEAEAAREKQRALQAL-------EELRLQAEEAERRLRQAEVERARQVQVA 1544
Query: 1119 PNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGG 1178
AE E + + ++ L E SL+E V + + E+ + ++
Sbjct: 1545 LETAQRSAEAELQSKRASFAEKTAQL-ERSLQEEHVAVAQLREEAERRAQ------QQAE 1597
Query: 1179 GERLSEARDTEHKDREELSSRENRALK---EGHRQDGEGALAAPEAEPAGKVQAPEGLIP 1235
ER AR+ ++ E + N AL+ + + +LA EAE + + E
Sbjct: 1598 AER---AREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK--QKEEAEREAR 1652
Query: 1236 ATGQAEELAAKDHDSC-AGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDP 1294
G+AEE A + + LE + + G Q+ +A E ++ + E ++
Sbjct: 1653 RRGKAEEQAVRQRELAEQELEKQRQLAEGT-----AQQRLAAEQELIRLRAETEQGEQQR 1707
Query: 1295 EEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAA 1354
+ E++ L+ EA + + E + E + + A E T+E +
Sbjct: 1708 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE---ESRSTSEKSK 1764
Query: 1355 EEREVLAG------SETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEEL 1408
+ E AG E A + +A +A +AEE+ Q+ A A +V+ E+L
Sbjct: 1765 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR-------AEAERVLAEKL 1817
Query: 1409 ARSGE 1413
A GE
Sbjct: 1818 AAIGE 1822
Score = 51.2 bits (121), Expect = 8e-06
Identities = 106/492 (21%), Positives = 188/492 (38%), Gaps = 58/492 (11%)
Query: 1032 EEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDA 1091
EE AE R ++R+ + E++ A E+++ + K +ERE +++E
Sbjct: 1323 EEEERLAEQQRAEERERLA--EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1380
Query: 1092 FKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKE 1151
+EE + A++ + + ++ ++ S+AE +A +E ++ L E+ ++
Sbjct: 1381 RREEAAVDAQQQKRSIQEELQQLRQS------SEAEIQAKARQAEAAERSRLRIEEEIRV 1434
Query: 1152 TVVPIFEATP----GFEKSLENITALRKEGGGERLSEARDTEHKDRE------------- 1194
+ + EAT G E L+ + A +E ++ + E R+
Sbjct: 1435 VRLQL-EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1493
Query: 1195 ELSSR---ENRALKEGHR------------QDGEGALAAPEAEPAGKVQAPEGLIPATGQ 1239
EL+SR E A +E R ++ E L E E A +VQ + +
Sbjct: 1494 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1553
Query: 1240 AE--ELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEE 1297
AE A + A LE + + LR + + AE+ REEA E +
Sbjct: 1554 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1613
Query: 1298 EDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEER 1357
L + ++ + E QK E A G+ E A +R
Sbjct: 1614 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE--------AEREARRRGKAEEQAVRQR 1665
Query: 1358 EVLAGSETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEELARSGEEVPA 1417
E LA E +++ +A + AE+E + E + +++ EELAR E A
Sbjct: 1666 E-LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE-TEQGEQQRQLLEEELARLQREAAA 1723
Query: 1418 AEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEG---SEGQEAATGSGDGRQETGAAEKF 1474
A + E +E + + +EE SE + + GR A E
Sbjct: 1724 ATQKRQELEAEL-AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA 1782
Query: 1475 RL-GLSREGERE 1485
RL L+ E +R+
Sbjct: 1783 RLRALAEEAKRQ 1794
Score = 39.7 bits (91), Expect = 0.023
Identities = 154/756 (20%), Positives = 270/756 (35%), Gaps = 113/756 (14%)
Query: 800 EAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAEG----AAEAEGVRRLGEGG 855
E VH L K A E A+ E+++ +E +G +AEAE V L E
Sbjct: 978 ETRTVHRLRLPLDKEPAR--ECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1035
Query: 856 -SDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANE------- 907
+ P ++ + +G ++ A+ L L+T G QG E+ + A+E
Sbjct: 1036 PAAPTLRSELELTLG-KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ 1094
Query: 908 AAALNLEHLHEV-AALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKR 966
A L L A+L++ E + A+ D +E L+ D +R
Sbjct: 1095 AVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1154
Query: 967 --EDGSE-----EAILGGEEPAKERKEVMRTETR--------LSPFTGEAEASRMQV--- 1008
E ++ +A+L + + E + + R L + +A + Q+
Sbjct: 1155 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1214
Query: 1009 --SEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERP 1066
++ L +E L +E E V E + + I EL L + + E
Sbjct: 1215 PLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV 1274
Query: 1067 KTSLRK------TDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPN 1120
+ +K ++S +E E Q +K +ET R EEE +
Sbjct: 1275 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI---SETLRRMEEEERLAEQ 1331
Query: 1121 EMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGE 1180
+ + E A VEA+ EK + + +
Sbjct: 1332 QRAEERERLAEVEAA---------------------------LEKQ-RQLAEAHAQAKAQ 1363
Query: 1181 RLSEARDTEHKDREELSSRENRAL-----KEGHRQDGEGALAAPEAEPAGKVQAPEGLIP 1235
EA++ + + +EE+ RE A+ K +++ + + EAE K + E
Sbjct: 1364 AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1423
Query: 1236 ATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEA--VDED 1293
+ + EE + LE +GG + L+ A AEE + +EEA +
Sbjct: 1424 SRLRIEE---EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1480
Query: 1294 PEEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETA 1353
++E ++ E E +E + E + Q A+E L E AE
Sbjct: 1481 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQ-----------ALEELRLQAEEAERR 1529
Query: 1354 AEE------REVLAGSETAE---EKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVV 1404
+ R+V ETA+ E + +K +SF++ + Q+E V A +
Sbjct: 1530 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV--AVAQLREE 1587
Query: 1405 VEELARSGEEVPAAEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEGSEGQEAATGSGDG 1464
E A+ E A E + AL L + EE ++ + A +
Sbjct: 1588 AERRAQQQAEAERAREEAERELERWQLKANEALR-----LRLQAEEVAQQKSLAQAEAEK 1642
Query: 1465 RQETGAAEKFRLGLSRE---GERELSPESLQAMATL 1497
++E E R G + E +REL+ + L+ L
Sbjct: 1643 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1678
Score = 37.7 bits (86), Expect = 0.086
Identities = 49/210 (23%), Positives = 82/210 (39%), Gaps = 23/210 (10%)
Query: 457 SAQEIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQG----EK 512
SA+ TG K+ + + +L+D L+ + +D E+ E
Sbjct: 3984 SAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEV 4043
Query: 513 SNEEGQADVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEE 572
+ + G D +MN I P DD K DP E + + + + D G L+E
Sbjct: 4044 AYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMER--CITDPQTGLCLLPLKE 4101
Query: 573 DKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKS 632
K++ KT+S +S R + D E + S E+ R+ ++
Sbjct: 4102 KKRERKTSSKSSVRKR--------RVVIVDPETGKEMSVYEAYRKGLID--------HQT 4145
Query: 633 HLPIEESLEIEIEDQEITKADVETKPMPID 662
+L + E E E E+ I+ +D K M ID
Sbjct: 4146 YLELSEQ-ECEWEEITISSSDGVVKSMIID 4174
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 80.9 bits (198), Expect = 9e-15
Identities = 222/1041 (21%), Positives = 391/1041 (37%), Gaps = 140/1041 (13%)
Query: 417 STEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQ-EIKTG----LKEVVTA 471
+T+K +EL+ KVR E E ++ + +E S S K + E + G L E
Sbjct: 1732 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1791
Query: 472 VEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPL 531
+ + + K +++ E+D + E E GE + + +A++ +
Sbjct: 1792 LRALAEEAKRQRQLAEEDAARQ-RAEAERVLAEKLAAIGEATRLKTEAEIALK------- 1843
Query: 532 DDKKDNLDPEKESETSSQKAPDARDNVK--DENDGCSESELEEDKQDMKTAS-STSSRSH 588
+ E E+E + A D + +E ++++EE ++ AS S R
Sbjct: 1844 -------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1896
Query: 589 PYSSDSEDESAVGDREAHTDSSTDESARRSSSQ---ELSENDKPRKSHLPIEESLEIEIE 645
D+ + + E ++ E A ++ EL + L +E E+E
Sbjct: 1897 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1956
Query: 646 DQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSKLW 705
Q A+ E + +E + L E Q A L E EE + + +
Sbjct: 1957 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA-ALEEVERLKAKVEEARRLRERAE 2015
Query: 706 EESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQK 765
+ES Q++ LA A +E A + ++ +Q +Q+
Sbjct: 2016 QESARQLQ----------------------LAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2053
Query: 766 TYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEF 825
TL++++++ D ++G+ EAA A EA ++A + A+ EE
Sbjct: 2054 --TLQQEQSV----------LDQLRGEAEAAR-RAAEEAEEARVQAEREAAQSRRQVEE- 2099
Query: 826 TEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTV 885
ER + A E R + ++ + + A ++A ++ E +
Sbjct: 2100 ---------AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2150
Query: 886 LETDKAASEGEQGL-EKAVLANEAAALNL---EHLHEVAALREAATSEEGEA-EGGVAVS 940
E +K EQ L +KA + E L L E H+ L E + EA E S
Sbjct: 2151 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2210
Query: 941 DVGESEEEASIDLEDTGPMEDTASK-------REDGSEEAILGGEEPAKERKEVMRTETR 993
V E + +E+ ++ R+ + + L +E A++ K+V R
Sbjct: 2211 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL--QEEAEKMKQVAEEAAR 2268
Query: 994 LSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKE 1053
LS EA R E ++ +LA E + E+M EA R E+L ++
Sbjct: 2269 LSVAAQEAARLRQLAEEDLAQQRALA-------EKMLKEKMQAVQEATRLKAEAELLQQQ 2321
Query: 1054 LDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAE- 1112
+LA+E+ R+ ++E++ + A E+ ++ L+AE + + E+ AE
Sbjct: 2322 KELAQEQ---------ARRLQEDKEQMAQQLA---EETQGFQRTLEAER-QRQLEMSAEA 2368
Query: 1113 EETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITA 1172
E K EM S A+ A +A +GE + + + T ++LE I
Sbjct: 2369 ERLKLRVAEM-SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT--LVQTLE-IQR 2424
Query: 1173 LRKEGGGERLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKVQAPEG 1232
+ + ERL EA +++E+L E L ++E VQ E
Sbjct: 2425 QQSDHDAERLREAIAELEREKEKLQQ--------------EAKLLQLKSEEMQTVQ-QEQ 2469
Query: 1233 LIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDE 1292
L+ T ++ + DS E E Q + Q+ VA+ + E+ R++ E
Sbjct: 2470 LLQETQALQQSFLSEKDSLLQRERFIE-QEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2528
Query: 1293 DPEE------EEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGG 1346
+ EE + E E R E +E + Q+ E + E L
Sbjct: 2529 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE-QQRRQQEELLAEENQRLREQLQLL 2587
Query: 1347 GETAETAAEEREVLAGSETAEEKTIANKASSF-SDVAEEETWHQQDELVGKTAA-----A 1400
E A E + S+ A KT+ N + AE E H D L K +A A
Sbjct: 2588 EEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEA 2647
Query: 1401 GKVVVEELARSGEEVPAAEEM 1421
G + EEL R + +E+
Sbjct: 2648 GILSAEELQRLAQGHTTVDEL 2668
Score = 72.0 bits (175), Expect = 4e-12
Identities = 212/1051 (20%), Positives = 408/1051 (38%), Gaps = 140/1051 (13%)
Query: 414 KEKSTEKGEELK-KAEGKVRKEREYVIPKRNEIKENKTSV--SAKFSAQEIKTGLKEVVT 470
K+++ + EEL+ +AE R+ R+ + + +++ + SA+ Q + E
Sbjct: 1517 KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA 1576
Query: 471 AVEEMTSKGKPGQEVLEDDQENTLKYEYE-----EDFEVDEEKQGEKSNEEGQADVQMNG 525
+E + L ++ E + + E E+ E + E+ K+NE + +Q
Sbjct: 1577 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1636
Query: 526 IPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSS 585
+ Q + EK+ E + + +AR K E + EL E + + + + +
Sbjct: 1637 VAQQK---SLAQAEAEKQKEEAER---EARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1690
Query: 586 RSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIE 645
+++ E ++ E R+ +EL+ + + + LE E+
Sbjct: 1691 AQQRLAAEQELI------RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1744
Query: 646 DQEITKADVETKPMPIDESFENVLKEGTEKGTQEI-AEG-----LSEKSGKHVSAEEKEK 699
+A++E + E + +EK Q + AE L+E++ + + E+ K
Sbjct: 1745 K---VRAEMEVL-LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1800
Query: 700 DKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKES 759
+ +L EE A+ + + + + A+G T E A E+
Sbjct: 1801 RQRQLAEEDAAR-----------QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1849
Query: 760 QQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQP 819
++L + + E++A QH+ ADI + + ++ + L + T Q
Sbjct: 1850 ERLRRLAEDEAFQRRRLEEQAAQHK-ADIEERLAQLRKASDSELERQKGLV--EDTLRQR 1906
Query: 820 ELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQ 879
EE E + E+ A G AE E LG S+ +K+ L EA ++
Sbjct: 1907 RQVEE--EILALKASFEKAAAGKAELE--LELGRIRSNAEDTLRSKEQAEL---EAARQR 1959
Query: 880 ALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAV 939
L E ++ E E+ ++K++ A E AA + AAL E + + E +
Sbjct: 1960 QL---AAEEERRRREAEERVQKSLAAEEEAARQRK-----AALEEVERLK-AKVEEARRL 2010
Query: 940 SDVGESEEEASIDLEDTGPMEDTASKREDGSEEA-ILGGEEPAKERKEVMRTETR-LSPF 997
+ E E + L ++ A KR E+A ++ +E ++ ++ E L
Sbjct: 2011 RERAEQESARQLQLA-----QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2065
Query: 998 TGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLA 1057
GEAEA+R E EE + E +E + V EAE ++ ++ A
Sbjct: 2066 RGEAEAARRAAEEA--EEARVQAE----REAAQSRRQVEEAERLKQSAEEQ--------A 2111
Query: 1058 RERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKA 1117
+ R +A+ LRK ++E+E RA A ++ A +++Q A + E E + E+T
Sbjct: 2112 QARAQAQAAAEKLRK-EAEQEAARRAQA--EQAALRQKQ---AADAEMEKHKKFAEQTLR 2165
Query: 1118 PPNEMGSDAENEAPVEASELSDNPGLLGED--SLKETVVPIFEATPGFEKSL-------E 1168
++ + ++ E LL E+ LK E+ L E
Sbjct: 2166 QKAQVEQEL-TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2224
Query: 1169 NITALRKEGGGE-RLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKV 1227
++ L+ E R RD ++ R E +K+ + ++AA EA ++
Sbjct: 2225 ELSKLKARIEAENRALILRDKDNTQR--FLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2282
Query: 1228 QAPEGLIPATGQAEELAAKDHDS---CAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEK 1284
A E L AE++ + + L+ AE +L+ Q+ +A+E ++
Sbjct: 2283 -AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE-------LLQQQKELAQEQARRLQE 2334
Query: 1285 FREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGD-------------MEGEGNTQ---- 1327
+E+ + EE + + TLE E + + + E + Q
Sbjct: 2335 DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2394
Query: 1328 ----------KNEGMGGGRVVAVEVLHGGGETAETAAEE-REVLAGSETAEEKTIANKAS 1376
+ E +V V+ L + ++ AE RE +A E +EK + +A
Sbjct: 2395 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK-LQQEAK 2453
Query: 1377 SFSDVAEEETWHQQDELVGKTAAAGKVVVEE 1407
+EE QQ++L+ +T A + + E
Sbjct: 2454 LLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2484
Score = 66.2 bits (160), Expect = 2e-10
Identities = 164/817 (20%), Positives = 333/817 (40%), Gaps = 119/817 (14%)
Query: 411 KSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVT 470
+S+++ E + + A + R+ RE E + K+ + + +A++ K L+EV
Sbjct: 1946 RSKEQAELEAARQRQLAAEEERRRREA------EERVQKSLAAEEEAARQRKAALEEV-- 1997
Query: 471 AVEEMTSKGKPGQEVLED-DQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQS 529
E + +K + + + E +QE+ + + ++ + EK++ A Q Q
Sbjct: 1998 --ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH--AFAVQQKEQELQQ 2053
Query: 530 PLDDKKDNLDPEK-ESETSSQKAPDARD-NVKDENDGCSESELEEDKQDMKTASSTSSRS 587
L ++ LD + E+E + + A +A + V+ E + E+ + +K ++ +++
Sbjct: 2054 TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2113
Query: 588 HPYSSDSEDE-SAVGDREAHTDSSTDESARRSSSQELSENDKPRK---SHLPIEESLEIE 643
+ + ++ ++EA + +++A R +E +K +K L + +E E
Sbjct: 2114 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2173
Query: 644 IEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSK 703
+ + + + + +DE + + E TE Q ++ E V EE K K++
Sbjct: 2174 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR-SQVEEELFSVRVQMEELSKLKAR 2232
Query: 704 LWEESTAQV-KDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQL 762
+ E+ A + +DK L+E + +A A ++ E A + E
Sbjct: 2233 IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA----RLSVAAQEAARLRQLAEEDLA 2288
Query: 763 VQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELA 822
Q+ L +K E+ +A Q + + K EA L + + + R + EQ +A
Sbjct: 2289 QQRA--LAEKMLKEKMQAVQ----EATRLKAEAELLQQQKELAQEQARRLQEDKEQ--MA 2340
Query: 823 EEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALM 882
++ E+ + G + EAE R+L + + E + L
Sbjct: 2341 QQLAEETQ-------GFQRTLEAERQRQL---------------------EMSAEAERLK 2372
Query: 883 LTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDV 942
L V E +A + E+ ++ +A + E LH E AT E+ + +
Sbjct: 2373 LRVAEMSRAQARAEEDAQR--FRKQAEEIG-EKLHRT----ELATQEKVTLVQTLEIQRQ 2425
Query: 943 GESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAE 1002
+S+ +A E +E K + ++ L EE ++E + ET+
Sbjct: 2426 -QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA-------- 2476
Query: 1003 ASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEM----VTEAEANREDDRKEILPKELDLAR 1058
+Q S S ++ L +E F+ +E + E++ V +A+ RE+ +++ E + R
Sbjct: 2477 ---LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2533
Query: 1059 -------ERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRA 1111
RR+ + +R+ E +++ + ++E +E Q+L+ + E + RA
Sbjct: 2534 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2593
Query: 1112 EEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENIT 1171
S+ + V A++ N G D+L P EA P E S +
Sbjct: 2594 A--------LAHSEEVTASQVAATKTLPN----GRDALDG---PAAEAEP--EHSFD--- 2633
Query: 1172 ALRKEGGGERLSEARDTEHKDREELSSRENRALKEGH 1208
LR++ +RL EA LS+ E + L +GH
Sbjct: 2634 GLRRKVSAQRLQEA--------GILSAEELQRLAQGH 2662
Score = 59.7 bits (143), Expect = 2e-08
Identities = 118/545 (21%), Positives = 215/545 (39%), Gaps = 61/545 (11%)
Query: 886 LETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGES 945
+E ++ +E ++ E+ LA AAL + A + A +E E + +
Sbjct: 1330 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1389
Query: 946 EEEASIDLED--TGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEA 1003
EEA++D + E+ R+ E + + +R E + + EA
Sbjct: 1390 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1449
Query: 1004 SRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKA 1063
+ Q E +L A E+ E ++ + EA R R+++ D ++ +R+A
Sbjct: 1450 TERQRGGAEGELQALRARA----EEAEAQKRQAQEEAERL--RRQV----QDESQRKRQA 1499
Query: 1064 ERPKTSLRKTDSE--REEVTRANALKDEDAFKEEQKLKAEEGE---TETEVRAEEETKAP 1118
E S K ++E RE+ AL EE +L+AEE E + EV + +
Sbjct: 1500 EVELASRVKAEAEAAREKQRALQAL-------EELRLQAEEAERRLRQAEVERARQVQVA 1552
Query: 1119 PNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGG 1178
AE E + + ++ L E SL+E V + + E+ + ++
Sbjct: 1553 LETAQRSAEAELQSKRASFAEKTAQL-ERSLQEEHVAVAQLREEAERRAQ------QQAE 1605
Query: 1179 GERLSEARDTEHKDREELSSRENRALK---EGHRQDGEGALAAPEAEPAGKVQAPEGLIP 1235
ER AR+ ++ E + N AL+ + + +LA EAE + + E
Sbjct: 1606 AER---AREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK--QKEEAEREAR 1660
Query: 1236 ATGQAEELAAKDHDSC-AGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDP 1294
G+AEE A + + LE + + G Q+ +A E ++ + E ++
Sbjct: 1661 RRGKAEEQAVRQRELAEQELEKQRQLAEGT-----AQQRLAAEQELIRLRAETEQGEQQR 1715
Query: 1295 EEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAA 1354
+ E++ L+ EA + + E + E + + A E T+E +
Sbjct: 1716 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE---ESRSTSEKSK 1772
Query: 1355 EEREVLAG------SETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEEL 1408
+ E AG E A + +A +A +AEE+ Q+ A A +V+ E+L
Sbjct: 1773 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR-------AEAERVLAEKL 1825
Query: 1409 ARSGE 1413
A GE
Sbjct: 1826 AAIGE 1830
Score = 51.2 bits (121), Expect = 8e-06
Identities = 106/492 (21%), Positives = 188/492 (38%), Gaps = 58/492 (11%)
Query: 1032 EEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDA 1091
EE AE R ++R+ + E++ A E+++ + K +ERE +++E
Sbjct: 1331 EEEERLAEQQRAEERERLA--EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1388
Query: 1092 FKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKE 1151
+EE + A++ + + ++ ++ S+AE +A +E ++ L E+ ++
Sbjct: 1389 RREEAAVDAQQQKRSIQEELQQLRQS------SEAEIQAKARQAEAAERSRLRIEEEIRV 1442
Query: 1152 TVVPIFEATP----GFEKSLENITALRKEGGGERLSEARDTEHKDRE------------- 1194
+ + EAT G E L+ + A +E ++ + E R+
Sbjct: 1443 VRLQL-EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1501
Query: 1195 ELSSR---ENRALKEGHR------------QDGEGALAAPEAEPAGKVQAPEGLIPATGQ 1239
EL+SR E A +E R ++ E L E E A +VQ + +
Sbjct: 1502 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1561
Query: 1240 AE--ELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEE 1297
AE A + A LE + + LR + + AE+ REEA E +
Sbjct: 1562 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1621
Query: 1298 EDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEER 1357
L + ++ + E QK E A G+ E A +R
Sbjct: 1622 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE--------AEREARRRGKAEEQAVRQR 1673
Query: 1358 EVLAGSETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEELARSGEEVPA 1417
E LA E +++ +A + AE+E + E + +++ EELAR E A
Sbjct: 1674 E-LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE-TEQGEQQRQLLEEELARLQREAAA 1731
Query: 1418 AEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEG---SEGQEAATGSGDGRQETGAAEKF 1474
A + E +E + + +EE SE + + GR A E
Sbjct: 1732 ATQKRQELEAEL-AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA 1790
Query: 1475 RL-GLSREGERE 1485
RL L+ E +R+
Sbjct: 1791 RLRALAEEAKRQ 1802
Score = 39.7 bits (91), Expect = 0.023
Identities = 154/756 (20%), Positives = 270/756 (35%), Gaps = 113/756 (14%)
Query: 800 EAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAEG----AAEAEGVRRLGEGG 855
E VH L K A E A+ E+++ +E +G +AEAE V L E
Sbjct: 986 ETRTVHRLRLPLDKEPAR--ECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1043
Query: 856 -SDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANE------- 907
+ P ++ + +G ++ A+ L L+T G QG E+ + A+E
Sbjct: 1044 PAAPTLRSELELTLG-KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ 1102
Query: 908 AAALNLEHLHEV-AALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKR 966
A L L A+L++ E + A+ D +E L+ D +R
Sbjct: 1103 AVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1162
Query: 967 --EDGSE-----EAILGGEEPAKERKEVMRTETR--------LSPFTGEAEASRMQV--- 1008
E ++ +A+L + + E + + R L + +A + Q+
Sbjct: 1163 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1222
Query: 1009 --SEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERP 1066
++ L +E L +E E V E + + I EL L + + E
Sbjct: 1223 PLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV 1282
Query: 1067 KTSLRK------TDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPN 1120
+ +K ++S +E E Q +K +ET R EEE +
Sbjct: 1283 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI---SETLRRMEEEERLAEQ 1339
Query: 1121 EMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGE 1180
+ + E A VEA+ EK + + +
Sbjct: 1340 QRAEERERLAEVEAA---------------------------LEKQ-RQLAEAHAQAKAQ 1371
Query: 1181 RLSEARDTEHKDREELSSRENRAL-----KEGHRQDGEGALAAPEAEPAGKVQAPEGLIP 1235
EA++ + + +EE+ RE A+ K +++ + + EAE K + E
Sbjct: 1372 AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1431
Query: 1236 ATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEA--VDED 1293
+ + EE + LE +GG + L+ A AEE + +EEA +
Sbjct: 1432 SRLRIEE---EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1488
Query: 1294 PEEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETA 1353
++E ++ E E +E + E + Q A+E L E AE
Sbjct: 1489 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQ-----------ALEELRLQAEEAERR 1537
Query: 1354 AEE------REVLAGSETAE---EKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVV 1404
+ R+V ETA+ E + +K +SF++ + Q+E V A +
Sbjct: 1538 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV--AVAQLREE 1595
Query: 1405 VEELARSGEEVPAAEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEGSEGQEAATGSGDG 1464
E A+ E A E + AL L + EE ++ + A +
Sbjct: 1596 AERRAQQQAEAERAREEAERELERWQLKANEALR-----LRLQAEEVAQQKSLAQAEAEK 1650
Query: 1465 RQETGAAEKFRLGLSRE---GERELSPESLQAMATL 1497
++E E R G + E +REL+ + L+ L
Sbjct: 1651 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1686
Score = 37.7 bits (86), Expect = 0.086
Identities = 49/210 (23%), Positives = 82/210 (39%), Gaps = 23/210 (10%)
Query: 457 SAQEIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQG----EK 512
SA+ TG K+ + + +L+D L+ + +D E+ E
Sbjct: 3992 SAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEV 4051
Query: 513 SNEEGQADVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEE 572
+ + G D +MN I P DD K DP E + + + + D G L+E
Sbjct: 4052 AYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMER--CITDPQTGLCLLPLKE 4109
Query: 573 DKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKS 632
K++ KT+S +S R + D E + S E+ R+ ++
Sbjct: 4110 KKRERKTSSKSSVRKR--------RVVIVDPETGKEMSVYEAYRKGLID--------HQT 4153
Query: 633 HLPIEESLEIEIEDQEITKADVETKPMPID 662
+L + E E E E+ I+ +D K M ID
Sbjct: 4154 YLELSEQ-ECEWEEITISSSDGVVKSMIID 4182
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 80.9 bits (198), Expect = 9e-15
Identities = 222/1041 (21%), Positives = 391/1041 (37%), Gaps = 140/1041 (13%)
Query: 417 STEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQ-EIKTG----LKEVVTA 471
+T+K +EL+ KVR E E ++ + +E S S K + E + G L E
Sbjct: 1773 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1832
Query: 472 VEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPL 531
+ + + K +++ E+D + E E GE + + +A++ +
Sbjct: 1833 LRALAEEAKRQRQLAEEDAARQ-RAEAERVLAEKLAAIGEATRLKTEAEIALK------- 1884
Query: 532 DDKKDNLDPEKESETSSQKAPDARDNVK--DENDGCSESELEEDKQDMKTAS-STSSRSH 588
+ E E+E + A D + +E ++++EE ++ AS S R
Sbjct: 1885 -------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQK 1937
Query: 589 PYSSDSEDESAVGDREAHTDSSTDESARRSSSQ---ELSENDKPRKSHLPIEESLEIEIE 645
D+ + + E ++ E A ++ EL + L +E E+E
Sbjct: 1938 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA 1997
Query: 646 DQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSKLW 705
Q A+ E + +E + L E Q A L E EE + + +
Sbjct: 1998 RQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA-ALEEVERLKAKVEEARRLRERAE 2056
Query: 706 EESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQK 765
+ES Q++ LA A +E A + ++ +Q +Q+
Sbjct: 2057 QESARQLQ----------------------LAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2094
Query: 766 TYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEF 825
TL++++++ D ++G+ EAA A EA ++A + A+ EE
Sbjct: 2095 --TLQQEQSV----------LDQLRGEAEAAR-RAAEEAEEARVQAEREAAQSRRQVEE- 2140
Query: 826 TEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTV 885
ER + A E R + ++ + + A ++A ++ E +
Sbjct: 2141 ---------AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2191
Query: 886 LETDKAASEGEQGL-EKAVLANEAAALNL---EHLHEVAALREAATSEEGEA-EGGVAVS 940
E +K EQ L +KA + E L L E H+ L E + EA E S
Sbjct: 2192 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2251
Query: 941 DVGESEEEASIDLEDTGPMEDTASK-------REDGSEEAILGGEEPAKERKEVMRTETR 993
V E + +E+ ++ R+ + + L +E A++ K+V R
Sbjct: 2252 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL--QEEAEKMKQVAEEAAR 2309
Query: 994 LSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKE 1053
LS EA R E ++ +LA E + E+M EA R E+L ++
Sbjct: 2310 LSVAAQEAARLRQLAEEDLAQQRALA-------EKMLKEKMQAVQEATRLKAEAELLQQQ 2362
Query: 1054 LDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAE- 1112
+LA+E+ R+ ++E++ + A E+ ++ L+AE + + E+ AE
Sbjct: 2363 KELAQEQ---------ARRLQEDKEQMAQQLA---EETQGFQRTLEAER-QRQLEMSAEA 2409
Query: 1113 EETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITA 1172
E K EM S A+ A +A +GE + + + T ++LE I
Sbjct: 2410 ERLKLRVAEM-SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT--LVQTLE-IQR 2465
Query: 1173 LRKEGGGERLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKVQAPEG 1232
+ + ERL EA +++E+L E L ++E VQ E
Sbjct: 2466 QQSDHDAERLREAIAELEREKEKLQQ--------------EAKLLQLKSEEMQTVQ-QEQ 2510
Query: 1233 LIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDE 1292
L+ T ++ + DS E E Q + Q+ VA+ + E+ R++ E
Sbjct: 2511 LLQETQALQQSFLSEKDSLLQRERFIE-QEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2569
Query: 1293 DPEE------EEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGG 1346
+ EE + E E R E +E + Q+ E + E L
Sbjct: 2570 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE-QQRRQQEELLAEENQRLREQLQLL 2628
Query: 1347 GETAETAAEEREVLAGSETAEEKTIANKASSF-SDVAEEETWHQQDELVGKTAA-----A 1400
E A E + S+ A KT+ N + AE E H D L K +A A
Sbjct: 2629 EEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEA 2688
Query: 1401 GKVVVEELARSGEEVPAAEEM 1421
G + EEL R + +E+
Sbjct: 2689 GILSAEELQRLAQGHTTVDEL 2709
Score = 72.0 bits (175), Expect = 4e-12
Identities = 212/1051 (20%), Positives = 408/1051 (38%), Gaps = 140/1051 (13%)
Query: 414 KEKSTEKGEELK-KAEGKVRKEREYVIPKRNEIKENKTSV--SAKFSAQEIKTGLKEVVT 470
K+++ + EEL+ +AE R+ R+ + + +++ + SA+ Q + E
Sbjct: 1558 KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA 1617
Query: 471 AVEEMTSKGKPGQEVLEDDQENTLKYEYE-----EDFEVDEEKQGEKSNEEGQADVQMNG 525
+E + L ++ E + + E E+ E + E+ K+NE + +Q
Sbjct: 1618 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1677
Query: 526 IPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSS 585
+ Q + EK+ E + + +AR K E + EL E + + + + +
Sbjct: 1678 VAQQK---SLAQAEAEKQKEEAER---EARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1731
Query: 586 RSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIE 645
+++ E ++ E R+ +EL+ + + + LE E+
Sbjct: 1732 AQQRLAAEQELI------RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1785
Query: 646 DQEITKADVETKPMPIDESFENVLKEGTEKGTQEI-AEG-----LSEKSGKHVSAEEKEK 699
+A++E + E + +EK Q + AE L+E++ + + E+ K
Sbjct: 1786 K---VRAEMEVL-LASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1841
Query: 700 DKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKES 759
+ +L EE A+ + + + + A+G T E A E+
Sbjct: 1842 RQRQLAEEDAAR-----------QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1890
Query: 760 QQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQP 819
++L + + E++A QH+ ADI + + ++ + L + T Q
Sbjct: 1891 ERLRRLAEDEAFQRRRLEEQAAQHK-ADIEERLAQLRKASDSELERQKGLV--EDTLRQR 1947
Query: 820 ELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQ 879
EE E + E+ A G AE E LG S+ +K+ L EA ++
Sbjct: 1948 RQVEE--EILALKASFEKAAAGKAELE--LELGRIRSNAEDTLRSKEQAEL---EAARQR 2000
Query: 880 ALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAV 939
L E ++ E E+ ++K++ A E AA + AAL E + + E +
Sbjct: 2001 QL---AAEEERRRREAEERVQKSLAAEEEAARQRK-----AALEEVERLK-AKVEEARRL 2051
Query: 940 SDVGESEEEASIDLEDTGPMEDTASKREDGSEEA-ILGGEEPAKERKEVMRTETR-LSPF 997
+ E E + L ++ A KR E+A ++ +E ++ ++ E L
Sbjct: 2052 RERAEQESARQLQLA-----QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL 2106
Query: 998 TGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLA 1057
GEAEA+R E EE + E +E + V EAE ++ ++ A
Sbjct: 2107 RGEAEAARRAAEEA--EEARVQAE----REAAQSRRQVEEAERLKQSAEEQ--------A 2152
Query: 1058 RERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKA 1117
+ R +A+ LRK ++E+E RA A ++ A +++Q A + E E + E+T
Sbjct: 2153 QARAQAQAAAEKLRK-EAEQEAARRAQA--EQAALRQKQ---AADAEMEKHKKFAEQTLR 2206
Query: 1118 PPNEMGSDAENEAPVEASELSDNPGLLGED--SLKETVVPIFEATPGFEKSL-------E 1168
++ + ++ E LL E+ LK E+ L E
Sbjct: 2207 QKAQVEQEL-TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2265
Query: 1169 NITALRKEGGGE-RLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKV 1227
++ L+ E R RD ++ R E +K+ + ++AA EA ++
Sbjct: 2266 ELSKLKARIEAENRALILRDKDNTQR--FLQEEAEKMKQVAEEAARLSVAAQEAARLRQL 2323
Query: 1228 QAPEGLIPATGQAEELAAKDHDS---CAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEK 1284
A E L AE++ + + L+ AE +L+ Q+ +A+E ++
Sbjct: 2324 -AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE-------LLQQQKELAQEQARRLQE 2375
Query: 1285 FREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGD-------------MEGEGNTQ---- 1327
+E+ + EE + + TLE E + + + E + Q
Sbjct: 2376 DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2435
Query: 1328 ----------KNEGMGGGRVVAVEVLHGGGETAETAAEE-REVLAGSETAEEKTIANKAS 1376
+ E +V V+ L + ++ AE RE +A E +EK + +A
Sbjct: 2436 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK-LQQEAK 2494
Query: 1377 SFSDVAEEETWHQQDELVGKTAAAGKVVVEE 1407
+EE QQ++L+ +T A + + E
Sbjct: 2495 LLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2525
Score = 66.2 bits (160), Expect = 2e-10
Identities = 164/817 (20%), Positives = 333/817 (40%), Gaps = 119/817 (14%)
Query: 411 KSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVT 470
+S+++ E + + A + R+ RE E + K+ + + +A++ K L+EV
Sbjct: 1987 RSKEQAELEAARQRQLAAEEERRRREA------EERVQKSLAAEEEAARQRKAALEEV-- 2038
Query: 471 AVEEMTSKGKPGQEVLED-DQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQS 529
E + +K + + + E +QE+ + + ++ + EK++ A Q Q
Sbjct: 2039 --ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAH--AFAVQQKEQELQQ 2094
Query: 530 PLDDKKDNLDPEK-ESETSSQKAPDARD-NVKDENDGCSESELEEDKQDMKTASSTSSRS 587
L ++ LD + E+E + + A +A + V+ E + E+ + +K ++ +++
Sbjct: 2095 TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2154
Query: 588 HPYSSDSEDE-SAVGDREAHTDSSTDESARRSSSQELSENDKPRK---SHLPIEESLEIE 643
+ + ++ ++EA + +++A R +E +K +K L + +E E
Sbjct: 2155 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2214
Query: 644 IEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSK 703
+ + + + + +DE + + E TE Q ++ E V EE K K++
Sbjct: 2215 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR-SQVEEELFSVRVQMEELSKLKAR 2273
Query: 704 LWEESTAQV-KDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQL 762
+ E+ A + +DK L+E + +A A ++ E A + E
Sbjct: 2274 IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA----RLSVAAQEAARLRQLAEEDLA 2329
Query: 763 VQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELA 822
Q+ L +K E+ +A Q + + K EA L + + + R + EQ +A
Sbjct: 2330 QQRA--LAEKMLKEKMQAVQ----EATRLKAEAELLQQQKELAQEQARRLQEDKEQ--MA 2381
Query: 823 EEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALM 882
++ E+ + G + EAE R+L + + E + L
Sbjct: 2382 QQLAEETQ-------GFQRTLEAERQRQL---------------------EMSAEAERLK 2413
Query: 883 LTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDV 942
L V E +A + E+ ++ +A + E LH E AT E+ + +
Sbjct: 2414 LRVAEMSRAQARAEEDAQR--FRKQAEEIG-EKLHRT----ELATQEKVTLVQTLEIQRQ 2466
Query: 943 GESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAE 1002
+S+ +A E +E K + ++ L EE ++E + ET+
Sbjct: 2467 -QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA-------- 2517
Query: 1003 ASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEM----VTEAEANREDDRKEILPKELDLAR 1058
+Q S S ++ L +E F+ +E + E++ V +A+ RE+ +++ E + R
Sbjct: 2518 ---LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2574
Query: 1059 -------ERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRA 1111
RR+ + +R+ E +++ + ++E +E Q+L+ + E + RA
Sbjct: 2575 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA 2634
Query: 1112 EEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENIT 1171
S+ + V A++ N G D+L P EA P E S +
Sbjct: 2635 A--------LAHSEEVTASQVAATKTLPN----GRDALDG---PAAEAEP--EHSFD--- 2674
Query: 1172 ALRKEGGGERLSEARDTEHKDREELSSRENRALKEGH 1208
LR++ +RL EA LS+ E + L +GH
Sbjct: 2675 GLRRKVSAQRLQEA--------GILSAEELQRLAQGH 2703
Score = 59.7 bits (143), Expect = 2e-08
Identities = 118/545 (21%), Positives = 215/545 (39%), Gaps = 61/545 (11%)
Query: 886 LETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGES 945
+E ++ +E ++ E+ LA AAL + A + A +E E + +
Sbjct: 1371 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1430
Query: 946 EEEASIDLED--TGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEA 1003
EEA++D + E+ R+ E + + +R E + + EA
Sbjct: 1431 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA 1490
Query: 1004 SRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKA 1063
+ Q E +L A E+ E ++ + EA R R+++ D ++ +R+A
Sbjct: 1491 TERQRGGAEGELQALRARA----EEAEAQKRQAQEEAERL--RRQV----QDESQRKRQA 1540
Query: 1064 ERPKTSLRKTDSE--REEVTRANALKDEDAFKEEQKLKAEEGE---TETEVRAEEETKAP 1118
E S K ++E RE+ AL EE +L+AEE E + EV + +
Sbjct: 1541 EVELASRVKAEAEAAREKQRALQAL-------EELRLQAEEAERRLRQAEVERARQVQVA 1593
Query: 1119 PNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGG 1178
AE E + + ++ L E SL+E V + + E+ + ++
Sbjct: 1594 LETAQRSAEAELQSKRASFAEKTAQL-ERSLQEEHVAVAQLREEAERRAQ------QQAE 1646
Query: 1179 GERLSEARDTEHKDREELSSRENRALK---EGHRQDGEGALAAPEAEPAGKVQAPEGLIP 1235
ER AR+ ++ E + N AL+ + + +LA EAE + + E
Sbjct: 1647 AER---AREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK--QKEEAEREAR 1701
Query: 1236 ATGQAEELAAKDHDSC-AGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDP 1294
G+AEE A + + LE + + G Q+ +A E ++ + E ++
Sbjct: 1702 RRGKAEEQAVRQRELAEQELEKQRQLAEGT-----AQQRLAAEQELIRLRAETEQGEQQR 1756
Query: 1295 EEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAA 1354
+ E++ L+ EA + + E + E + + A E T+E +
Sbjct: 1757 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE---ESRSTSEKSK 1813
Query: 1355 EEREVLAG------SETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEEL 1408
+ E AG E A + +A +A +AEE+ Q+ A A +V+ E+L
Sbjct: 1814 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR-------AEAERVLAEKL 1866
Query: 1409 ARSGE 1413
A GE
Sbjct: 1867 AAIGE 1871
Score = 51.2 bits (121), Expect = 8e-06
Identities = 106/492 (21%), Positives = 188/492 (38%), Gaps = 58/492 (11%)
Query: 1032 EEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDA 1091
EE AE R ++R+ + E++ A E+++ + K +ERE +++E
Sbjct: 1372 EEEERLAEQQRAEERERLA--EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1429
Query: 1092 FKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKE 1151
+EE + A++ + + ++ ++ S+AE +A +E ++ L E+ ++
Sbjct: 1430 RREEAAVDAQQQKRSIQEELQQLRQS------SEAEIQAKARQAEAAERSRLRIEEEIRV 1483
Query: 1152 TVVPIFEATP----GFEKSLENITALRKEGGGERLSEARDTEHKDRE------------- 1194
+ + EAT G E L+ + A +E ++ + E R+
Sbjct: 1484 VRLQL-EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEV 1542
Query: 1195 ELSSR---ENRALKEGHR------------QDGEGALAAPEAEPAGKVQAPEGLIPATGQ 1239
EL+SR E A +E R ++ E L E E A +VQ + +
Sbjct: 1543 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1602
Query: 1240 AE--ELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEE 1297
AE A + A LE + + LR + + AE+ REEA E +
Sbjct: 1603 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1662
Query: 1298 EDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEER 1357
L + ++ + E QK E A G+ E A +R
Sbjct: 1663 LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE--------AEREARRRGKAEEQAVRQR 1714
Query: 1358 EVLAGSETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEELARSGEEVPA 1417
E LA E +++ +A + AE+E + E + +++ EELAR E A
Sbjct: 1715 E-LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE-TEQGEQQRQLLEEELARLQREAAA 1772
Query: 1418 AEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEG---SEGQEAATGSGDGRQETGAAEKF 1474
A + E +E + + +EE SE + + GR A E
Sbjct: 1773 ATQKRQELEAEL-AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA 1831
Query: 1475 RL-GLSREGERE 1485
RL L+ E +R+
Sbjct: 1832 RLRALAEEAKRQ 1843
Score = 39.7 bits (91), Expect = 0.023
Identities = 154/756 (20%), Positives = 270/756 (35%), Gaps = 113/756 (14%)
Query: 800 EAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAEG----AAEAEGVRRLGEGG 855
E VH L K A E A+ E+++ +E +G +AEAE V L E
Sbjct: 1027 ETRTVHRLRLPLDKEPAR--ECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1084
Query: 856 -SDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANE------- 907
+ P ++ + +G ++ A+ L L+T G QG E+ + A+E
Sbjct: 1085 PAAPTLRSELELTLG-KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ 1143
Query: 908 AAALNLEHLHEV-AALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKR 966
A L L A+L++ E + A+ D +E L+ D +R
Sbjct: 1144 AVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1203
Query: 967 --EDGSE-----EAILGGEEPAKERKEVMRTETR--------LSPFTGEAEASRMQV--- 1008
E ++ +A+L + + E + + R L + +A + Q+
Sbjct: 1204 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1263
Query: 1009 --SEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERP 1066
++ L +E L +E E V E + + I EL L + + E
Sbjct: 1264 PLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV 1323
Query: 1067 KTSLRK------TDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPN 1120
+ +K ++S +E E Q +K +ET R EEE +
Sbjct: 1324 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI---SETLRRMEEEERLAEQ 1380
Query: 1121 EMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGE 1180
+ + E A VEA+ EK + + +
Sbjct: 1381 QRAEERERLAEVEAA---------------------------LEKQ-RQLAEAHAQAKAQ 1412
Query: 1181 RLSEARDTEHKDREELSSRENRAL-----KEGHRQDGEGALAAPEAEPAGKVQAPEGLIP 1235
EA++ + + +EE+ RE A+ K +++ + + EAE K + E
Sbjct: 1413 AEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1472
Query: 1236 ATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEA--VDED 1293
+ + EE + LE +GG + L+ A AEE + +EEA +
Sbjct: 1473 SRLRIEE---EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ 1529
Query: 1294 PEEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETA 1353
++E ++ E E +E + E + Q A+E L E AE
Sbjct: 1530 VQDESQRKRQAEVELASRVKAEAEAAREKQRALQ-----------ALEELRLQAEEAERR 1578
Query: 1354 AEE------REVLAGSETAE---EKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVV 1404
+ R+V ETA+ E + +K +SF++ + Q+E V A +
Sbjct: 1579 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV--AVAQLREE 1636
Query: 1405 VEELARSGEEVPAAEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEGSEGQEAATGSGDG 1464
E A+ E A E + AL L + EE ++ + A +
Sbjct: 1637 AERRAQQQAEAERAREEAERELERWQLKANEALR-----LRLQAEEVAQQKSLAQAEAEK 1691
Query: 1465 RQETGAAEKFRLGLSRE---GERELSPESLQAMATL 1497
++E E R G + E +REL+ + L+ L
Sbjct: 1692 QKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQL 1727
Score = 37.7 bits (86), Expect = 0.086
Identities = 49/210 (23%), Positives = 82/210 (39%), Gaps = 23/210 (10%)
Query: 457 SAQEIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQG----EK 512
SA+ TG K+ + + +L+D L+ + +D E+ E
Sbjct: 4033 SAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEV 4092
Query: 513 SNEEGQADVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEE 572
+ + G D +MN I P DD K DP E + + + + D G L+E
Sbjct: 4093 AYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMER--CITDPQTGLCLLPLKE 4150
Query: 573 DKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKS 632
K++ KT+S +S R + D E + S E+ R+ ++
Sbjct: 4151 KKRERKTSSKSSVRKR--------RVVIVDPETGKEMSVYEAYRKGLID--------HQT 4194
Query: 633 HLPIEESLEIEIEDQEITKADVETKPMPID 662
+L + E E E E+ I+ +D K M ID
Sbjct: 4195 YLELSEQ-ECEWEEITISSSDGVVKSMIID 4223
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 78.6 bits (192), Expect = 4e-14
Identities = 203/982 (20%), Positives = 375/982 (38%), Gaps = 130/982 (13%)
Query: 403 LDKKPSLPKSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIK 462
L+ K R E E EL + K+ E + ++++ V + A E K
Sbjct: 917 LEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENK 976
Query: 463 T-GLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADV 521
L E + ++E+ +K ++ L++ + L +D +V+E+K S + + +
Sbjct: 977 VKNLTEEMAGLDEIIAKLTKEKKALQEAHQQAL-----DDLQVEEDKVNSLSKSKVKLEQ 1031
Query: 522 QMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKD-ENDGCS-ESELEEDKQDMKT 579
Q++ + S +KK +D E+ ++++ D END E +L++ + D+
Sbjct: 1032 QVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDI-- 1089
Query: 580 ASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEES 639
+ +S EDE + L K +++ IEE
Sbjct: 1090 --------NQQNSKIEDEQVLA---------------------LQLQKKLKENQARIEE- 1119
Query: 640 LEIEIEDQEITKADVETKPMPIDESFENVLKEGTEK-GTQEIAEGLSEKSGKHVSAEEKE 698
LE E+E + +A VE + E + + E G + +++K ++
Sbjct: 1120 LEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRD 1179
Query: 699 KDKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKE 758
+++ L E+TA KK E G + L F + E + SN E
Sbjct: 1180 LEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKL-ELDDVTSNME 1238
Query: 759 SQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQ 818
Q+++ LEK ED+A ++R L ++++ + K E
Sbjct: 1239 --QIIKAKANLEKVSRTLEDQANEYR----------VKLEEAQRSLNDFTTQRAKLQTEN 1286
Query: 819 PELAEEFTEKREIPPGIERGAEGAAE--AEGVRRLGEGGSDPIGQAAAK-------DAVG 869
ELA + EK + + RG + + R+L E G A A D +
Sbjct: 1287 GELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLR 1346
Query: 870 LSKDEAPEKQALMLTVL--------------ETD------------KAASEGEQGLEKAV 903
+E E +A + VL ETD K ++ Q E+AV
Sbjct: 1347 EQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAV 1406
Query: 904 LANEAAALNLEHL-HEVAALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDT 962
A A +LE H + E + + A D + + I E E++
Sbjct: 1407 EAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFD-KILAEWKQKYEES 1465
Query: 963 ASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEASRMQVSEGSPEEGSLAKEA 1022
S+ E +EA E K + + L F E + + ++S+ + + G K
Sbjct: 1466 QSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNV 1525
Query: 1023 F--------LCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTD 1074
L E +E + + EAEA+ E + +IL +L+ + + + ER L + D
Sbjct: 1526 HELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIER---KLAEKD 1582
Query: 1075 SEREEVTR-----ANALK---DEDAFKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDA 1126
E E+ R ++L+ D + + L+ ++ + E ++ E + N M ++A
Sbjct: 1583 EEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKK-KMEGDLNEMEIQLSHANRMAAEA 1641
Query: 1127 ENEAPVEASELSD-----NPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGER 1181
+ + S L D + + D LKE + + + LE + A+ ++ R
Sbjct: 1642 QKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSR 1701
Query: 1182 -LSEARDTEHKDREELSSRENRAL-KEGHRQDGEGALAAPEAEPA------GKVQAPEGL 1233
L+E E +R +L +N +L + + + + E E A + +A + +
Sbjct: 1702 KLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAI 1761
Query: 1234 IPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDED 1293
A AEEL K+ D+ A LE + L+ + AE+ + K + + ++
Sbjct: 1762 TDAAMMAEEL-KKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEAR 1820
Query: 1294 PEEEEDKECTLETEAMQDRNSE 1315
E E E EA Q RN+E
Sbjct: 1821 VRELEG-----ELEAEQKRNAE 1837
Score = 42.0 bits (97), Expect = 0.005
Identities = 154/780 (19%), Positives = 287/780 (36%), Gaps = 104/780 (13%)
Query: 398 IIAMGLDKKPSLPKSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFS 457
++A+ L KK ++R E+ E+ E + A KV K R + + EI E S
Sbjct: 1101 VLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATS 1160
Query: 458 AQEIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEG 517
Q +E + Q++ D +E TL ++E +K + E G
Sbjct: 1161 VQ------------IEMNKKREAEFQKMRRDLEEATL--QHEATAAALRKKHADSVAELG 1206
Query: 518 QADVQMNGIPQSPLDDKKDNLDPEKESETSS-QKAPDARDNVKDEN----DGCSESELEE 572
+ + + Q L+ +K E + TS+ ++ A+ N++ + D +E ++
Sbjct: 1207 EQIDNLQRVKQK-LEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKL 1265
Query: 573 DKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQE-----LSEND 627
++ T+ R+ + + E + ++EA T + E L E
Sbjct: 1266 EEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEG 1325
Query: 628 KPRKSHLPIEESLEIEIEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEK 687
K + + + +L+ D ++ + E + E L+ K E+A+ ++
Sbjct: 1326 KAKNA---LAHALQSARHDCDLLREQYEEETEAKAE-----LQRVLSKANSEVAQWRTKY 1377
Query: 688 SGKHVS-AEEKEKDKSKLW------EESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGA 740
+ EE E+ K KL EE+ V K + L + ++ +
Sbjct: 1378 ETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIE--------- 1428
Query: 741 PTMNFMVD------ETAAINSNKESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGE 794
+ MVD AA++ + + + + + +E+ E E+ Q +
Sbjct: 1429 ---DLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSL-----S 1480
Query: 795 AALWGEAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEG 854
L+ A E+ E L EE ++ E + G + E E VR+ E
Sbjct: 1481 TELFKLKNAYEESLEHLETFKRENKNLQEEISDLTE---QLGEGGKNVHELEKVRKQLEV 1537
Query: 855 GSDPIGQAAAKDAVGLSKDEAPEKQALM---LTVLETDKAASEGEQGLEKA------VLA 905
+ A + L +E +A + E ++ +E ++ +E+A V+
Sbjct: 1538 EKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVD 1597
Query: 906 NEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGESEEEASID-------LEDTGP 958
+ +L+ E LR E E + +S EA L+DT
Sbjct: 1598 SLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQI 1657
Query: 959 MEDTASKREDGSEEAILGGE--------EPAKERKEVMRTETRLSPFTGEAEASRMQVSE 1010
D A + D +E I E E + R V +TE E + +V
Sbjct: 1658 QLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQL 1717
Query: 1011 GSPEEGSLAKEAFLCKEDV-----EGEEMVTEAEANREDDRKEILPKELDLARERRKA-- 1063
+ SL + + D+ E EE V E N E+ K+ + +A E +K
Sbjct: 1718 LHSQNTSLINQKKKMESDLTQLQSEVEEAVQECR-NAEEKAKKAITDAAMMAEELKKEQD 1776
Query: 1064 -----ERPKTSLRKTDSE-REEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKA 1117
ER K ++ +T + + + A + + K+ QKL+A E E E+ AE++ A
Sbjct: 1777 TSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNA 1836
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 75.9 bits (185), Expect = 3e-13
Identities = 138/616 (22%), Positives = 234/616 (37%), Gaps = 74/616 (12%)
Query: 402 GLDKKPSLPKSRKEKSTEKGEELKKAEGK--VRKEREYVIPKRNEIKENKTSVSAKFSAQ 459
GL K PS+ K KS EK + ++K+E + + +E+ E+ E + + + +
Sbjct: 425 GLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGK 484
Query: 460 EIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQA 519
E + G +E EE T K P +E ++E + EE E K EK + A
Sbjct: 485 EEEGGEEEEAEGGEEET-KSPPAEEAASPEKEAKSPVK-EEAKSPAEAKSPEKEEAKSPA 542
Query: 520 DVQMNGIPQSPLDDKKDNLDPEKESETSSQKAP-------DARDNVKDENDGCSESELEE 572
+V+ +SP ++ + K E K+P A+ K+E +E++ E
Sbjct: 543 EVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPE 602
Query: 573 DKQD--MKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDE--SARRSSSQELSENDK 628
+ + A S + P +++ + V E + +E S ++ S E E
Sbjct: 603 KAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKS 662
Query: 629 PRKSHLPIEESLEIEIEDQEITKADV---ETKPMPIDESFENVLK---------EGTEKG 676
P K+ P++ + + + KA+ E P+ E ++ K + EK
Sbjct: 663 PEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKA 722
Query: 677 TQEIAEGLS--EKSGKHVSAEEKEKDKSKLWEES-TAQVKDKKAGLPGLEEGGK--DSLP 731
+ E EK+ V E K +K+K E++ T VK +A P EE D P
Sbjct: 723 KSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFP 782
Query: 732 LAYVLALGAPTMNFMVDETAAINSNKESQQLVQKTYTL--EKKEAMEEDEAPQHRDADIV 789
+P + A + KE + +K E K ++E+E PQ
Sbjct: 783 ----EKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEP 838
Query: 790 QGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEFTEKREIP---------PGIERGAE 840
K E E A T E+ + +E K+E P P +E+ E
Sbjct: 839 PKKAE-----------EEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKE 887
Query: 841 GAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLE 900
EA+ + P + A V + +D P+++ + D A E + E
Sbjct: 888 SKVEAK-KEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAE 946
Query: 901 KAVLANEAAALNLEHLHEVAALREAATSEEGEA-EGGVAVS------DVGESEEEASIDL 953
K EAA + E A E E +A E +S ++E+ +S D
Sbjct: 947 K----KEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQ 1002
Query: 954 EDTGP----MEDTASK 965
+D+ P ED A+K
Sbjct: 1003 KDSKPPEKATEDKAAK 1018
Score = 72.0 bits (175), Expect = 4e-12
Identities = 145/716 (20%), Positives = 271/716 (37%), Gaps = 118/716 (16%)
Query: 420 KGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVTAVEEMTSKG 479
+GEE + G + +PK + + V ++ + ++ KE V VEE T +
Sbjct: 407 EGEECRIGFGPIPFSLPEGLPKIPSVSTH-IKVKSEEKIKVVEKSEKETVI-VEEQTEET 464
Query: 480 KPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPLDDKKDNLD 539
+ +EV E++++ + E +E+ E EE++ E EE +SP ++ + +
Sbjct: 465 QVTEEVTEEEEKEAKEEEGKEE-EGGEEEEAEGGEEE----------TKSPPAEEAASPE 513
Query: 540 PEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSSRSHPYSSDSEDESA 599
E +S + A ++ + S +E++ ++ K+ + ++S P + E E A
Sbjct: 514 KEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEK-AKSPAKEEAKSPPEAKSPEKEEA 572
Query: 600 VGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIED----QEITKADVE 655
E + A+ + +E P K+ P++E + E +E K+ E
Sbjct: 573 KSPAEVKSPEKAKSPAKEEAKSP-AEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAE 631
Query: 656 TK-PMPIDESFENVLKEGTEKGTQEIAEGLS-EKSGKHVSAEEKEKDKSKLWEESTAQVK 713
K P + K + + E E S EK+ V AE K +K+K ++ A+
Sbjct: 632 VKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAK-S 690
Query: 714 DKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQKTYTLEKKE 773
+KA P EE +P A + KE + +K + K+E
Sbjct: 691 PEKAKSPVKEEAKSPE-------KAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEE 743
Query: 774 AMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPP 833
A ++A A + K A + P K A P A++F EK + P
Sbjct: 744 AKSPEKAKSPEKAKTLDVKSPEA---------KTPA---KEEARSP--ADKFPEKAKSP- 788
Query: 834 GIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAAS 893
++ + +A ++ K+ + E P+K+ + V E +K
Sbjct: 789 -VKEEVKSPEKA---------------KSPLKEDAKAPEKEIPKKEEVKSPVKEEEKP-- 830
Query: 894 EGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGESEEEASIDL 953
EV +EE +A ++EE+
Sbjct: 831 -----------------------QEVKVKEPPKKAEEEKAPA------TPKTEEKKDSKK 861
Query: 954 EDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEASRMQVSEGS- 1012
E+ E K E+ E A+ +E E K+ + + P + ++++V E +
Sbjct: 862 EEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAK 921
Query: 1013 -PEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRK--AERPKTS 1069
E+ +AK+ +D + +E AE +KE P++ D E+ K E+PKT
Sbjct: 922 PKEKTEVAKKE---PDDAKAKEPSKPAE------KKEAAPEKKDTKEEKAKKPEEKPKTE 972
Query: 1070 LRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPNEMGSD 1125
+ + D+ KE K KAE+ E + +++ PP + D
Sbjct: 973 AKAKED------------DKTLSKEPSKPKAEKAEKSSS--TDQKDSKPPEKATED 1014
Score = 67.0 bits (162), Expect = 1e-10
Identities = 128/557 (22%), Positives = 206/557 (36%), Gaps = 69/557 (12%)
Query: 817 EQPELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAP 876
E+ ++ EE TE+ E E G E E G EGG + A++A +P
Sbjct: 462 EETQVTEEVTEEEEKEAKEEEGKE---EEGGEEEEAEGGEEETKSPPAEEAA------SP 512
Query: 877 EKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHL-----HEVAALREAATSEEG 931
EK+A V E K+ +E + EK + A + E E + EA + E+
Sbjct: 513 EKEAKS-PVKEEAKSPAEAKSP-EKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKE 570
Query: 932 EAEGGVAVSDVGESE----EEASIDLEDTGPMEDTASKREDGSE--EAILGGEEPAKERK 985
EA+ V +++ EEA E P + + +E+ EA +E AK
Sbjct: 571 EAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPA 630
Query: 986 EVMRTETRLSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMV---TEAEANR 1042
EV E SP EA++ S E S K K + + E +AEA
Sbjct: 631 EVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKS 690
Query: 1043 EDDRKEILPKEL-----------DLARERRKAERPKTSLRKTDSEREEVTRANALKDEDA 1091
+ K + +E + A+ KA+ P KT + + + A E A
Sbjct: 691 PEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKA 750
Query: 1092 FKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDS-LK 1150
E+ + E + A+EE ++P ++ A++ E L ED+
Sbjct: 751 KSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAP 810
Query: 1151 ETVVPIFEATPGFEKSLENITALRKEGGGERLSE------ARDTEHKDREELSSRENRAL 1204
E +P E K E ++ + ++ E + E KD ++ + + A
Sbjct: 811 EKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAP 870
Query: 1205 KEGHRQDGEGALAAP----------EAEPAGKVQAPEGLIPATGQAEELA-AKDHDSCAG 1253
K + E A+ P EAE KV PE PA + +E A K+ A
Sbjct: 871 KPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAK 930
Query: 1254 LEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEEEDKECTLETEAMQDRN 1313
E +A A+E AEK +E A ++ +EE + E + +
Sbjct: 931 KE--------------PDDAKAKEPSKPAEK-KEAAPEKKDTKEEKAKKPEEKPKTEAKA 975
Query: 1314 SEGDGDMEGEGNTQKNE 1330
E D + E + K E
Sbjct: 976 KEDDKTLSKEPSKPKAE 992
Score = 63.9 bits (154), Expect = 1e-09
Identities = 110/588 (18%), Positives = 230/588 (39%), Gaps = 67/588 (11%)
Query: 570 LEEDKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKP 629
+EE ++ + + + + E + G E + +E+ + ++E + +K
Sbjct: 457 VEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEET-KSPPAEEAASPEKE 515
Query: 630 RKSHLPIEESLEIEIE----DQEITKADVETK-PMPIDESFENVLKEGTEKGTQEIAEGL 684
KS P++E + E ++E K+ E K P + K E + E E
Sbjct: 516 AKS--PVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEA- 572
Query: 685 SEKSGKHVSAEEKEKDKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMN 744
KS V + EK K +K +S A+ K + ++E K + A +
Sbjct: 573 --KSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPA 630
Query: 745 FMVDETAAINSNKESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQG-KGEAALWGEAGA 803
+ A + KE + +K + EK+EA ++A A+ K ++ + EA
Sbjct: 631 EVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEA-- 688
Query: 804 VHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAA 863
++P +A P E+ + E+ A+ + E + E P+ + A
Sbjct: 689 --KSPEKAKSPVKEEAKSPEK--------------AKSPVKEEA--KSPEKAKSPVKEEA 730
Query: 864 AKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALR 923
+ PEK E + EKA +A L+++ +
Sbjct: 731 ----------KTPEK---------AKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAK 771
Query: 924 EAATS--EEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEP- 980
E A S ++ + V + +S E+A L++ + +++ + + E+P
Sbjct: 772 EEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQ 831
Query: 981 -AKERKEVMRTETRLSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAE 1039
K ++ + E +P T + E + E +P++ + + KE + ++ E
Sbjct: 832 EVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVE 891
Query: 1040 ANRED--DRKEI------LPKELDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDA 1091
A +E+ D+K++ P ++++ + + E+ + + ++ D + + A K E A
Sbjct: 892 AKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAA 951
Query: 1092 FKE----EQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEAS 1135
++ E+K K E + +TE +A+E+ K E +A +S
Sbjct: 952 PEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSS 999
Score = 55.8 bits (133), Expect = 3e-07
Identities = 154/712 (21%), Positives = 272/712 (38%), Gaps = 103/712 (14%)
Query: 833 PGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAA 892
P RGA A+ + + L G P G A V S+ E + QAL D+ A
Sbjct: 62 PSRFRGAGAASSTDSLDTLSNG---PEGCMVA---VATSRSEKEQLQAL------NDRFA 109
Query: 893 S--EGEQGLE--KAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGESEEE 948
+ + LE L EAAAL + +A+ E E E G AV +G + +
Sbjct: 110 GYIDKVRQLEAHNRSLEGEAAALRQQQAGR-SAMGELYEREVREMRG--AVLRLGAARGQ 166
Query: 949 ASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEASRMQV 1008
++ E +ED A R+ +EA ++R+E L+ F EAEA+R+ +
Sbjct: 167 LRLEQEHL--LEDIAHVRQRLDDEA--------RQREEAEAAARALARFAQEAEAARVDL 216
Query: 1009 SEGSPEEGSLAKEAFLCKEDVEGE--EMVTE------AEANREDDRKEILPKELDLARER 1060
+ + +L +E + + E E++ + A+A + + ++ L ++ A
Sbjct: 217 QKKAQ---ALQEECGYLRRHHQEEVGELLGQIQGSGAAQAQMQAETRDALKCDVTSALRE 273
Query: 1061 RKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPN 1120
+A+ +++ T + EE R + +A K E TE R + + +
Sbjct: 274 IRAQLEGHAVQST-LQSEEWFRVRLDRLSEAAKVNTDAMRSAQEEITEYRRQLQARTTEL 332
Query: 1121 EMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGE 1180
E ++ + SEL ED + + EA + L N K
Sbjct: 333 EALKSTKDSLERQRSEL--------EDRHQADIASYQEAIQQLDAELRNT----KWEMAA 380
Query: 1181 RLSEARDTEH-KDREELSSRENRALKEGHR-QDGEGALAAPEAEPAGKVQAPEGLIPATG 1238
+L E +D + K ++ R L EG + G G + PEGL
Sbjct: 381 QLREYQDLLNVKMALDIEIAAYRKLLEGEECRIGFGPIP---------FSLPEGLPKIPS 431
Query: 1239 QAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEEE 1298
+ + K + ++ E +E I+ E+ E V E+ EEE
Sbjct: 432 VSTHIKVKSEEK-----------------IKVVEKSEKETVIVEEQTEETQVTEEVTEEE 474
Query: 1299 DKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEERE 1358
+KE E + + EG + E EG ++ + + E E EE +
Sbjct: 475 EKEAKEE----EGKEEEGGEEEEAEGGEEETKSPPAEEAASPE-----KEAKSPVKEEAK 525
Query: 1359 VLAGSETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEELARSGEEVPAA 1418
A +++ E++ +A S ++V E + K+ K +E A+S EV +
Sbjct: 526 SPAEAKSPEKE----EAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSP 581
Query: 1419 EEMTVTYTTEA-GVGTPGALERKTSGLGQEQEEGSEGQEAATGSGDGRQETGAAEKFRLG 1477
E+ EA + E+ S + +E + +E + E + EK +
Sbjct: 582 EKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSP 641
Query: 1478 LSREG---ERELSPESLQA----MATLPVKPDFTETREKQQHMVQGESETAD 1522
E E+ SPE +A A PVK + ++ EK + V+ E+++ +
Sbjct: 642 TKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAE-AKSPEKAKSPVKAEAKSPE 692
Score = 50.4 bits (119), Expect = 1e-05
Identities = 48/207 (23%), Positives = 87/207 (42%), Gaps = 15/207 (7%)
Query: 409 LPKSRKEKSTEKGEE------LKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIK 462
+PK + KS K EE +K+ K +E+ PK E K++K + K A + K
Sbjct: 814 IPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPK 873
Query: 463 TGLKEVVTAVEEMTSKGKPGQEVLED-------DQENTLKYEYEEDFEVDEEKQGEKSNE 515
K+ + SK + +E ED ++E K E +ED + E+ + K E
Sbjct: 874 VEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAK-KE 932
Query: 516 EGQADVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQ 575
A + P + + D ++E ++ P K+++ S+ + +
Sbjct: 933 PDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAE 992
Query: 576 DMKTASSTSSR-SHPYSSDSEDESAVG 601
+ +SST + S P +ED++A G
Sbjct: 993 KAEKSSSTDQKDSKPPEKATEDKAAKG 1019
Score = 48.1 bits (113), Expect = 6e-05
Identities = 106/478 (22%), Positives = 178/478 (37%), Gaps = 55/478 (11%)
Query: 769 LEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEFTEK 828
LE++ +E+ + R D + + EA EA RA A++ E A +K
Sbjct: 169 LEQEHLLEDIAHVRQRLDDEARQREEA----------EAAARALARFAQEAEAARVDLQK 218
Query: 829 REIPPGIERGAEGAAEAEGVRRL-----GEGGSDPIGQAAAKDAVGLSKDEAPEKQALML 883
+ E G E V L G G + QA +DA+ A
Sbjct: 219 KAQALQEECGYLRRHHQEEVGELLGQIQGSGAAQAQMQAETRDALKCDVTSA-------- 270
Query: 884 TVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALR-EAATSEEGEAEGGVAVSDV 942
L +A EG ++ + + E + L+ L E A + +A S + E
Sbjct: 271 --LREIRAQLEGH-AVQSTLQSEEWFRVRLDRLSEAAKVNTDAMRSAQEEITEYRRQLQA 327
Query: 943 GESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAE 1002
+E EA +D+ +E S+ ED + I A ++ + + + L E
Sbjct: 328 RTTELEALKSTKDS--LERQRSELEDRHQADI------ASYQEAIQQLDAELRNTKWEMA 379
Query: 1003 ASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEM----------VTEAEANREDDRKEILPK 1052
A + + + +L E ++ +EGEE + E I K
Sbjct: 380 AQLREYQDLLNVKMALDIEIAAYRKLLEGEECRIGFGPIPFSLPEGLPKIPSVSTHIKVK 439
Query: 1053 ELDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAE 1112
+ + K+E+ +T + + +E +VT ++E KEE+ + E GE E E
Sbjct: 440 SEEKIKVVEKSEK-ETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGE 498
Query: 1113 EETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITA 1172
EETK+PP E + E EA E + +P +E +P KS E +
Sbjct: 499 EETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEA------KSPAEVKSPEKAKS 552
Query: 1173 LRKEGGGERLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKVQAP 1230
KE E S + E S E ++ ++ E A + EA+ K ++P
Sbjct: 553 PAKE---EAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSP 607
Score = 47.4 bits (111), Expect = 1e-04
Identities = 70/320 (21%), Positives = 128/320 (40%), Gaps = 44/320 (13%)
Query: 405 KKPSLPKSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTG 464
+K P + KS EK + +KA+ K E P + E + S + KF ++ K+
Sbjct: 734 EKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEAR----SPADKFP-EKAKSP 788
Query: 465 LKEVVTAVEEMTSKGK-----PGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQA 519
+KE V + E+ S K P +E+ + ++ + E E+ EV ++ +K+ EE
Sbjct: 789 VKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEE--- 845
Query: 520 DVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDEN--DGCSESELE---EDK 574
++P K + K+ E ++AP + K E + ES++E E+
Sbjct: 846 --------KAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEA 897
Query: 575 QDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHL 634
+D K + + ED E D A+ S + P K
Sbjct: 898 EDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDT 957
Query: 635 PIEESLEIEIEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSA 694
E++ + E + + KA KE + ++E ++ +EK+ K S
Sbjct: 958 KEEKAKKPEEKPKTEAKA-----------------KEDDKTLSKEPSKPKAEKAEKSSST 1000
Query: 695 EEKE-KDKSKLWEESTAQVK 713
++K+ K K E+ A+ K
Sbjct: 1001 DQKDSKPPEKATEDKAAKGK 1020
>gi|87299628 biorientation of chromosomes in cell division 1-like
[Homo sapiens]
Length = 3051
Score = 73.9 bits (180), Expect = 1e-12
Identities = 164/823 (19%), Positives = 318/823 (38%), Gaps = 141/823 (17%)
Query: 413 RKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVTAV 472
+K KST+KGE KK + + ER+ KE K KF + ++V
Sbjct: 314 QKNKSTDKGE--KKPDSNEKGERK---------KEKKEKTEKKFDHSKKSEDTQKV---K 359
Query: 473 EEMTSKGKPGQEVLEDDQENTLKYE----YEEDFEVDEEKQGEKSNEEGQADVQMNGIPQ 528
+E +K K + + ++N+ K + +EDF + + S+ +G D+ ++ +
Sbjct: 360 DEKQAKEKEVESLKLPSEKNSNKAKTVEGTKEDFSLID------SDVDGLTDITVSSVHT 413
Query: 529 SPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSSRSH 588
S L ++ D E+E TS D E E+ D ++ + T ++
Sbjct: 414 SDLSSFEE--DTEEEVVTS---------------DSMEEGEITSDDEEKNKQNKTKTQ-- 454
Query: 589 PYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIEDQE 648
+SDS + R A+ S S S + ++ R+S I + E + ++
Sbjct: 455 --TSDSSEGKTKSVRHAYVHKPYLYSKYYSDSDDELTVEQRRQS---IAKEKEERLLRRQ 509
Query: 649 ITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKS-KLWEE 707
I + +E K E ++ +G + + ++ E S KS + +A KE K K+ E+
Sbjct: 510 INREKLEEKRKQKAEKTKSSKTKGQGRSSVDLEES-STKSLEPKAARIKEVLKERKVLEK 568
Query: 708 STAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQKTY 767
A K +K +EE NS K+ Q
Sbjct: 569 KVALSKKRKKDSRNVEE-----------------------------NSKKKQQYEEDSKE 599
Query: 768 TLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEFTE 827
TL+ E E+++ ++ V K E + A + E+ L + +L E +
Sbjct: 600 TLKTSEHCEKEKISSSKELKHVHAKSEPS--KPARRLSES-LHVVDENKNESKLEREH-K 655
Query: 828 KREIPPGIERGAEGAAEAEGVRRLGEGG----SDPIGQ-AAAKDAVGLSKD--EAPEKQA 880
+R P I G + + V+R E +P Q + K+ L KD E P ++
Sbjct: 656 RRTSTPVIMEGVQEETDTRDVKRQVERSEICTEEPQKQKSTLKNEKHLKKDDSETPHLKS 715
Query: 881 LMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEE-GEAEGGVAV 939
L+ +++ K E E+ L+++H ++ + + E +E G+ V
Sbjct: 716 LLKKEVKSSKEKPEREK-------TPSEDKLSVKHKYKGDCMHKTGDETELHSSEKGLKV 768
Query: 940 SD-VGESEEEASIDLEDTGPMEDTASKREDGSEEAILGGE-EPAKE---------RKEVM 988
+ + + ++ + +D + SK + + ++LG + +P E RKE
Sbjct: 769 EENIQKQSQQTKLSSDD---KTERKSKHRNERKLSVLGKDGKPVSEYIIKTDENVRKENN 825
Query: 989 RTETRLSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKE 1048
+ E RLS +AE + S+ ++ SL + G + +E+ ED
Sbjct: 826 KKERRLSAEKTKAEHKSRRSSDSKIQKDSLGSKQ-------HGITLQRRSESYSED---- 874
Query: 1049 ILPKELDLARERRKAE-RPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETET 1107
+ D+ + +P+ + K + + + + + +++K E E +
Sbjct: 875 ----KCDMDSTNMDSNLKPEEVVHKEKRRTKSLLEEKLVLKSKSKTQGKQVKVVETELQE 930
Query: 1108 EVRAEEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKET-VVPIFEATPGFEKS 1166
+ T P E ++ + S++ D P +ET V P+ E S
Sbjct: 931 GATKQATTPKPDKEKNTEENDSEKQRKSKVEDKP-------FEETGVEPVLETASSSAHS 983
Query: 1167 LENITALRKEGGGERLSEARDTEHKDREELSSRENRALKEGHR 1209
+ ++ R +L A++ D++ S+R R L +GH+
Sbjct: 984 TQKDSSHR-----AKLPLAKEKYKSDKDSTSTRLERKLSDGHK 1021
Score = 53.1 bits (126), Expect = 2e-06
Identities = 232/1158 (20%), Positives = 413/1158 (35%), Gaps = 195/1158 (16%)
Query: 403 LDKKPSLPKSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKF-SAQEI 461
L+KK +L K RK+ S + E +K+++Y + +K ++ K S++E+
Sbjct: 566 LEKKVALSKKRKKDS-------RNVEENSKKKQQYEEDSKETLKTSEHCEKEKISSSKEL 618
Query: 462 KTGLKEVVTAVEEMTSKGKPGQEVLE-----DDQENTLKYEYEEDFE-----VDEEKQGE 511
K V + KP + + E D+ +N K E E + E Q E
Sbjct: 619 K--------HVHAKSEPSKPARRLSESLHVVDENKNESKLEREHKRRTSTPVIMEGVQEE 670
Query: 512 KSNEEGQADVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELE 571
+ + V+ + I +K L EK + + P + +K E +S E
Sbjct: 671 TDTRDVKRQVERSEICTEEPQKQKSTLKNEKHLKKDDSETPHLKSLLKKE----VKSSKE 726
Query: 572 EDKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDS---STDESARRSSSQ-ELSEND 627
+ +++ + S H Y D ++ + E H+ +E+ ++ S Q +LS +D
Sbjct: 727 KPEREKTPSEDKLSVKHKYKGDCMHKTG-DETELHSSEKGLKVEENIQKQSQQTKLSSDD 785
Query: 628 K-PRKSHLPIEESLEIEIEDQEITKADVETKPMP--IDESFENVLKEGTEKGTQEIAEGL 684
K RKS E L + +D KP+ I ++ ENV KE +K + AE
Sbjct: 786 KTERKSKHRNERKLSVLGKD---------GKPVSEYIIKTDENVRKENNKKERRLSAE-- 834
Query: 685 SEKSGKHVSAEEKEKDKSKLWEESTAQVKDKKAGLPGLEEGGKDSL-PLAYVLALGAPTM 743
+ K + KS+ +S Q KDSL + + L +
Sbjct: 835 ----------KTKAEHKSRRSSDSKIQ---------------KDSLGSKQHGITLQRRSE 869
Query: 744 NFMVD----ETAAINSNKESQQLVQK-----TYTLEKKEAMEEDEAPQHRDADIVQGKGE 794
++ D ++ ++SN + +++V K LE+K ++ Q + +V
Sbjct: 870 SYSEDKCDMDSTNMDSNLKPEEVVHKEKRRTKSLLEEKLVLKSKSKTQGKQVKVV----- 924
Query: 795 AALWGEAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEG 854
E A +A P ++ + EE +++ +E + E
Sbjct: 925 -----ETELQEGATKQATTPKPDKEKNTEENDSEKQRKSKVED-----------KPFEET 968
Query: 855 GSDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNLE 914
G +P+ + A+ A KD + +A + E K+ + + L++ + +L+
Sbjct: 969 GVEPVLETASSSAHSTQKDSS--HRAKLPLAKEKYKSDKDSTSTRLERKLSDGHKSRSLK 1026
Query: 915 HLHEVAALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKREDGSEEAI 974
H + ++ S++ + + +V S E+A ++ ME S+R +
Sbjct: 1027 HSSKDIKKKDENKSDDKDGK------EVDSSHEKAR---GNSSLMEKKLSRRLCENRRGS 1077
Query: 975 LGGEEPAKERKEVMRTETRLS--------------------PFTGEAEASRMQVSEGSPE 1014
L E E K T + S P ++E V E S
Sbjct: 1078 LSQEMAKGEEKLAANTLSTPSGSSLQRPKKSGDMTLIPEQEPMEIDSEPGVENVFEVSKT 1137
Query: 1015 EGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAER---PKTSLR 1071
+ + + ++D++ E M + A + D + K R ++
Sbjct: 1138 QDNRNNNS---QQDIDSENMKQKTSATVQKDELRTCTADSKATAPAYKPGRGTGVNSNSE 1194
Query: 1072 KTDSEREEVTRANALKDE-DAFKEEQKLKAEEGETETEVRAE-----------EETKAPP 1119
K R +T+ ++ +K G TE + +E E +
Sbjct: 1195 KHADHRSTLTKKMHIQSAVSKMNPGEKEPIHRGTTEVNIDSETVHRMLLSAPSENDRVQK 1254
Query: 1120 NEMGSDAENEAPVEASELSDNPGLLGEDSLKE-TVVPIFEA-TPGFEKSLENITALRKEG 1177
N + AE + L + L SL TVVP+ E+ P + T L EG
Sbjct: 1255 NLKNTAAEEHVAQGDATLEHSTNLDSSPSLSSVTVVPLRESYDPDVIPLFDKRTVL--EG 1312
Query: 1178 GGERLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKVQAPEGLIPAT 1237
S A D + L+ RE+ LK ++G PA + IP
Sbjct: 1313 STASTSPA-DHSALPNQSLTVRESEVLKTSDSKEGGEGFTVD--TPAKASITSKRHIPEA 1369
Query: 1238 GQAEELAAKDHDSCAGLEGRAEG----------QGG-VDVVLRTQEAVAEED-----PIM 1281
QA L K L + G +GG VD+ + + AE +
Sbjct: 1370 HQATLLDGKQGKVIMPLGSKLTGVIVENENITKEGGLVDMAKKENDLNAEPNLKQTIKAT 1429
Query: 1282 AEKFREEAVDEDPEEEEDKECTLETEAMQDRNSEG---DGDMEGEGNTQKNE-GMGGGRV 1337
E +++ + D + E ET ++ + S G D ++ E + +E G
Sbjct: 1430 VENGKKDGIAVDHVVGLNTEKYAETVKLKHKRSPGKVKDISIDVERRNENSEVDTSAGSG 1489
Query: 1338 VAVEVLH-GGGETAETAA----EEREVLAGSETAEEKTIANKASSFSDVAEEETWHQQDE 1392
A VLH G+T + A E+ +A S ++K + + +Q E
Sbjct: 1490 SAPSVLHQRNGQTEDVATGPRRAEKTSVATSTEGKDKDVTLSPVKAGPATTTSSETRQSE 1549
Query: 1393 L----VGKTAAAGKVVVEELARSGEEVPA-AEEMTVTYTTEAG--VGTPGALERKTSGLG 1445
+ A G ++ + V A A E TV E G V T G E +T
Sbjct: 1550 VALPCTSIEADEGLIIGTHSRNNPLHVGAEASECTVFAAAEEGGAVVTEGFAESET--FL 1607
Query: 1446 QEQEEGSEGQEAATGSGD 1463
+EG G+ A S D
Sbjct: 1608 TSTKEGESGECAVAESED 1625
Score = 49.3 bits (116), Expect = 3e-05
Identities = 207/1084 (19%), Positives = 371/1084 (34%), Gaps = 145/1084 (13%)
Query: 402 GLDKKPSLPKSRKEKSTEKGEELKKAEGKVRKE--REYVIPKRNEIKENKTSVSAKFSAQ 459
G K+ + PK KEK+TE+ + K+ + KV + E + E + + K S+
Sbjct: 931 GATKQATTPKPDKEKNTEENDSEKQRKSKVEDKPFEETGVEPVLETASSSAHSTQKDSSH 990
Query: 460 EIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQA 519
K L + ++ ++ + +++ + + +LK+ ++ + DE K +K +E +
Sbjct: 991 RAKLPLAKEKYKSDKDSTSTRLERKLSDGHKSRSLKHSSKDIKKKDENKSDDKDGKEVDS 1050
Query: 520 DVQMNGIPQSPLDDK-KDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMK 578
+ S ++ K L + S + A + S S L+ K+
Sbjct: 1051 SHEKARGNSSLMEKKLSRRLCENRRGSLSQEMAKGEEKLAANTLSTPSGSSLQRPKK--- 1107
Query: 579 TASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQEL-SENDKPRKSHLPIE 637
S P E +S G S T ++ +S Q++ SEN K + S +
Sbjct: 1108 ---SGDMTLIPEQEPMEIDSEPGVENVFEVSKTQDNRNNNSQQDIDSENMKQKTSATVQK 1164
Query: 638 ESLEIEIEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEK 697
+ L D + T K G +GT G++ S KH A+ +
Sbjct: 1165 DELRTCTADSKATAP---------------AYKPG--RGT-----GVNSNSEKH--ADHR 1200
Query: 698 EKDKSKLWEESTAQVKDKKAGLP---GLEEGGKDSLPLAYVLALGAPTMNFMV------- 747
K+ +S + P G E DS + + L AP+ N V
Sbjct: 1201 STLTKKMHIQSAVSKMNPGEKEPIHRGTTEVNIDS-ETVHRMLLSAPSENDRVQKNLKNT 1259
Query: 748 ---------DETAAINSNKESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGK------ 792
D T ++N +S + + +E+ + D P +++G
Sbjct: 1260 AAEEHVAQGDATLEHSTNLDSSPSLSSVTVVPLRESYDPDVIPLFDKRTVLEGSTASTSP 1319
Query: 793 -GEAALWGEAGAVHEAPLRAWKPTAEQPE-------LAEEFTEKREIPPGIERGAEGAAE 844
+AL ++ V E+ + + E E T KR IP + +
Sbjct: 1320 ADHSALPNQSLTVRESEVLKTSDSKEGGEGFTVDTPAKASITSKRHIPEAHQATLLDGKQ 1379
Query: 845 AEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVL 904
+ + LG + I + G D A ++ L + E G + +
Sbjct: 1380 GKVIMPLGSKLTGVIVENENITKEGGLVDMAKKENDLNAEPNLKQTIKATVENGKKDGIA 1439
Query: 905 ANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTAS 964
+ LN E E L+ + + + +++ DV E + +D +
Sbjct: 1440 VDHVVGLNTEKYAETVKLKHKRSPGKVK---DISI-DVERRNENSEVDTSAGSGSAPSVL 1495
Query: 965 KREDGSEEAILGGEEPAKERKEVMRTETRLSPFT-GEAEASRMQVSEGSPEEGSLAKEAF 1023
+ +G E + G A++ TE + T +A + + +A
Sbjct: 1496 HQRNGQTEDVATGPRRAEKTSVATSTEGKDKDVTLSPVKAGPATTTSSETRQSEVALPCT 1555
Query: 1024 LCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEVTRA 1083
+ D EG + T + N L + E + T + VT
Sbjct: 1556 SIEAD-EGLIIGTHSRNN-----------PLHVGAEASEC----TVFAAAEEGGAVVTEG 1599
Query: 1084 NALKDEDAFKEEQKLKAEEGE---TETEVRAEE-------ETKAPPNEMGSDAENEAPVE 1133
A + + F K + E GE E+E RA + + +A N + ++ +++A
Sbjct: 1600 FA--ESETFLTSTK-EGESGECAVAESEDRAADLLAVHAVKIEANVNSVVTEEKDDAVTS 1656
Query: 1134 ASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGERLSEARDTEHKDR 1193
A G L DS I E T F +E+ A+ G R
Sbjct: 1657 AGSEEKCDGSLSRDS------EIVEGTITFISEVESDGAVTSAGTEIRAGSI------SS 1704
Query: 1194 EELSSRENRALKEGHRQDGEGALAAPEAE----------PAGKVQAPEGLIPATGQAEEL 1243
EE+ + ++ G +++ EG + AE G E ++ G +
Sbjct: 1705 EEVDGSQGNMMRMGPKKETEGTVTCTGAEGRSDNFVICSVTGAGPREERMVTGAG----V 1760
Query: 1244 AAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEEEDKECT 1303
D+D+ G EG G V+ + E + + E+ E P E +
Sbjct: 1761 VLGDNDAPPGTSASQEGDGSVN------DGTEGESAVTSTGITEDG--EGPASCTGSEDS 1812
Query: 1304 LETEAMQDRNSE-GDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEEREVLAG 1362
E A+ + E G+ M+ +T EG V A G T+ A EE E G
Sbjct: 1813 SEGFAISSESEENGESAMD---STVAKEGTNVPLVAAGPCDDEGIVTSTGAKEEDE--EG 1867
Query: 1363 SETAEEKTIANK---ASSFSDVAEEETWHQQDELVGKTAAAGKVVVEELARSGEEVPAAE 1419
+ N+ AS+ + + EE E + G VV A +G + A
Sbjct: 1868 EDVVTSTGRGNEIGHASTCTGLGEESEGVLICESAEGDSQIGTVVEHVEAEAGAAIMNAN 1927
Query: 1420 EMTV 1423
E V
Sbjct: 1928 ENNV 1931
Score = 47.0 bits (110), Expect = 1e-04
Identities = 120/641 (18%), Positives = 235/641 (36%), Gaps = 103/641 (16%)
Query: 844 EAEGVRRLGEGGSDPIGQAAAKDAVGL-SKDEAPEKQALMLTVLETDKA-ASEGEQGLEK 901
EA R E + + A+K + D + +K+ + + +K+ A G +GLE
Sbjct: 214 EASAARASTETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLET 273
Query: 902 AVLANEAAAL--------NLEHLHEVAALREAATSEEGEAEGGVAVSDVGESEEEASIDL 953
A + E + L N H L +E + + +D GE + +++
Sbjct: 274 APKSEEFSDLPCPVEEIKNYTKEHNNLILLNKDVQQESSEQKNKS-TDKGEKKPDSNEKG 332
Query: 954 EDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEASRMQVSEGSP 1013
E ++ K+ D S+++ + K+ K+ E E +++ + EG+
Sbjct: 333 ERKKEKKEKTEKKFDHSKKS--EDTQKVKDEKQAKEKEVESLKLPSEKNSNKAKTVEGTK 390
Query: 1014 EEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKT 1073
E+ SL DV+G +T + + D S +
Sbjct: 391 EDFSLIDS------DVDGLTDITVSSVHTSD-----------------------LSSFEE 421
Query: 1074 DSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPP----------NEMG 1123
D+E E VT + + E +E+K K + +T+T +E +TK+ ++
Sbjct: 422 DTEEEVVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGKTKSVRHAYVHKPYLYSKYY 481
Query: 1124 SDAENEAPVE------ASELSDN--PGLLGEDSLKETVVPIFEATPGFE----------- 1164
SD+++E VE A E + + + L+E E T +
Sbjct: 482 SDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQKAEKTKSSKTKGQGRSSVDL 541
Query: 1165 -----KSLENITALRKEGGGERLSEARDTEHKDREELSSR---ENRALKEGHRQDGEGAL 1216
KSLE A KE ER + + + SR EN K+ + +D + L
Sbjct: 542 EESSTKSLEPKAARIKEVLKERKVLEKKVALSKKRKKDSRNVEENSKKKQQYEEDSKETL 601
Query: 1217 AAPEAEPAGKVQAPEGL----------IPATGQAEELAAKDHD-SCAGLEGRAEGQGGVD 1265
E K+ + + L PA +E L D + + + LE + +
Sbjct: 602 KTSEHCEKEKISSSKELKHVHAKSEPSKPARRLSESLHVVDENKNESKLEREHKRRTSTP 661
Query: 1266 VVLRTQEAVAEEDPIMAEKFREEAVDEDPEEE-----------EDKECTLETEAMQDRNS 1314
V++ + + + + R E E+P+++ +D T +++ +
Sbjct: 662 VIMEGVQEETDTRDVKRQVERSEICTEEPQKQKSTLKNEKHLKKDDSETPHLKSLLKKEV 721
Query: 1315 EGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEEREVLAGSETAEEKTIANK 1374
+ + T + + + +H G+ E + E+ L E ++++ K
Sbjct: 722 KSSKEKPEREKTPSEDKLSVKHKYKGDCMHKTGDETELHSSEKG-LKVEENIQKQSQQTK 780
Query: 1375 ASSFSDVAEEETWHQQDELVGKTAAAGKVVVEELARSGEEV 1415
SS D E ++ H+ + + GK V E + ++ E V
Sbjct: 781 LSS-DDKTERKSKHRNERKLSVLGKDGKPVSEYIIKTDENV 820
Score = 44.3 bits (103), Expect = 0.001
Identities = 120/592 (20%), Positives = 221/592 (37%), Gaps = 82/592 (13%)
Query: 950 SIDLEDTGPMEDTASKREDGSEEAILGGE----EPAKER-KEVMRTETRLSP-----FTG 999
S+ ED P TA S A G E PA R E +T P +
Sbjct: 2468 SLQKEDKSPETGTAGGSSTASYSAGRGLEGNANSPAHLRGPEQTSGQTAKDPSVSIRYLA 2527
Query: 1000 EAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEE--------MVTEAEANREDDRKEILP 1051
++ + P +G++A+ +FL E E+ +T E+ I P
Sbjct: 2528 AVNTGAIKADDMPPVQGTVAEHSFLPAEQQGSEDNLKTSTTKCITGQESKIAPSHTMIPP 2587
Query: 1052 KELDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRA 1111
+A K E+ T K D + +A+A K D +K EEG+ V +
Sbjct: 2588 ATYSVALLAPKCEQDLTI--KNDYSGKWTDQASAEKTGDD-NSTRKSFPEEGDIMVTVSS 2644
Query: 1112 EEET------KAPPNEMG-----SDAENEAPVEASELSDNPGLLGEDSL---KETVVPIF 1157
EE ++P N +G ++ + EA V + E + L +SL K + +
Sbjct: 2645 EENVCDIGNEESPLNVLGGLKLKANLKMEAYVPSEEEKNGEILAPPESLCGGKPSGIAEL 2704
Query: 1158 EATPGFEKSLENITALRKEGGGERLSEARDTEHKDREELSS--RENRALKEGHRQDGEGA 1215
+ P N+ E G R +E +E ++ E+SS ++N GH
Sbjct: 2705 QREPLLVNESLNV-----ENSGFRTNEEIHSESYNKGEISSGRKDNAEAISGH------- 2752
Query: 1216 LAAPEAEPAGKVQAPEGLIPATGQAEE-LAAKDH--DSCAGLEGRAEGQGGVDVVLRTQE 1272
+ EA+P +V+ E +P + + L+++D D+ L+ R E Q
Sbjct: 2753 --SVEADPK-EVEEEERHMPKRKRKQHYLSSEDEPDDNPDVLDSRIE---------TAQR 2800
Query: 1273 AVAEEDPIMAEKFREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNE-- 1330
E +P ++ ++E P+ + T + M++++ + GE Q ++
Sbjct: 2801 QCPETEPHDTKEENSRDLEELPKTSSETNSTT-SRVMEEKDEYSSSETTGEKPEQNDDDT 2859
Query: 1331 --GMGGGRVVAVEVLHGGG-----ETAETAAEEREVLAGSETAEEKTIANKASSF-SDVA 1382
+ + ++ G ET ++ + G T E+ ++K +D +
Sbjct: 2860 IKSQEEDQPIIIKRKRGRPRKYPVETTLKMKDDSKTDTGIVTVEQSPSSSKLKVMQTDES 2919
Query: 1383 EEETWHQQDELVGKTAAAGKVVVEELARSGEEVPA------AEEMTVTYTTEAGVGTPGA 1436
+ET + Q+ + K+V R + + AE + V P
Sbjct: 2920 NKETANLQERSISNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQKSVSDP-V 2978
Query: 1437 LERKTSGLGQEQEEGSEGQEAATGSGDGRQETGAAEKFRLGLSREGERELSP 1488
++K +E+EE E + + + + K +L S + +RE+SP
Sbjct: 2979 EDKKEQESDEEEEEEEEDEPSGATTRSTTRSEAQRSKTQLSPSIKRKREVSP 3030
Score = 39.7 bits (91), Expect = 0.023
Identities = 204/1021 (19%), Positives = 362/1021 (35%), Gaps = 163/1021 (15%)
Query: 435 REYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTL 494
RE + K ++ KE + A+ T + + A + GK G+ ++ + T
Sbjct: 1333 RESEVLKTSDSKEGGEGFTVDTPAKASITSKRHIPEAHQATLLDGKQGKVIMPLGSKLTG 1392
Query: 495 KYEYEEDFE-----VDEEKQGEKSNEEG------QADVQMNGIPQSPLDDKKDNLDPEKE 543
E+ VD K+ N E +A V+ NG D L+ EK
Sbjct: 1393 VIVENENITKEGGLVDMAKKENDLNAEPNLKQTIKATVE-NGKKDGIAVDHVVGLNTEKY 1451
Query: 544 SETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSSRSHPYSSDSEDESAVGDR 603
+ET K + VKD + + + S S H + +ED A G R
Sbjct: 1452 AETVKLKHKRSPGKVKDISIDVERRNENSEVDTSAGSGSAPSVLHQRNGQTEDV-ATGPR 1510
Query: 604 EAHTDSSTDESARRSSSQELSE---------NDKPRKSHLPIEESLEIEIEDQEITKADV 654
A S + + LS + + R+S + + IE ++ I
Sbjct: 1511 RAEKTSVATSTEGKDKDVTLSPVKAGPATTTSSETRQSEVALP-CTSIEADEGLIIGTHS 1569
Query: 655 ETKPMPID-ESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSKLWEESTAQVK 713
P+ + E+ E + E+G + EG +E S +E E E + A+ +
Sbjct: 1570 RNNPLHVGAEASECTVFAAAEEGGAVVTEGFAESETFLTSTKEGESG-----ECAVAESE 1624
Query: 714 DKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQKTYTLEKKE 773
D+ A L LA+ A I +N S +K +
Sbjct: 1625 DRAADL----------------LAVHA----------VKIEANVNSVVTEEKDDAVTSAG 1658
Query: 774 AMEEDEAPQHRDADIVQGKGEAALWGEA-GAVHEA--PLRAWKPTAEQPELAE----EFT 826
+ E+ + RD++IV+G E+ GAV A +RA ++E+ + ++
Sbjct: 1659 SEEKCDGSLSRDSEIVEGTITFISEVESDGAVTSAGTEIRAGSISSEEVDGSQGNMMRMG 1718
Query: 827 EKREIPPGIE-RGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTV 885
K+E + GAEG ++ + + G V D P A
Sbjct: 1719 PKKETEGTVTCTGAEGRSDNFVICSVTGAGPREERMVTGAGVVLGDNDAPPGTSASQ--- 1775
Query: 886 LETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEA------EGGVAV 939
E D + ++G +G E AV + E A+ + S EG A E G +
Sbjct: 1776 -EGDGSVNDGTEG-ESAVTSTGIT----EDGEGPASCTGSEDSSEGFAISSESEENGESA 1829
Query: 940 SDVGESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKER---KEVMRTETRLSP 996
D ++E ++ L GP +D G++E GE+ E+ T
Sbjct: 1830 MDSTVAKEGTNVPLVAAGPCDDEGIVTSTGAKEEDEEGEDVVTSTGRGNEIGHAST---- 1885
Query: 997 FTGEAEASR----MQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRK--EIL 1050
TG E S + +EG + G++ + + E + A N D E
Sbjct: 1886 CTGLGEESEGVLICESAEGDSQIGTVVEHV-----EAEAGAAIMNANENNVDSMSGTEKG 1940
Query: 1051 PKELDLARERRKAERPKTSLRKTDSEREEVT---------RANALKDEDAFKEEQKLKAE 1101
K+ D+ + ++S+ S ++EVT +A D+ + Q K E
Sbjct: 1941 SKDTDICSSAKGI--VESSVTSAVSGKDEVTPVPGGCEGPMTSAASDQ---SDSQLEKVE 1995
Query: 1102 E-----------------GET-ETEVRAEEETKAPPNEMGSDAENE------APVEASEL 1137
+ GE E EV ++ ++ + ENE A + ++
Sbjct: 1996 DTTISTGLVGGSYDVLVSGEVPECEVAHTSPSEKEDEDIITSVENEECDGLMATTASGDI 2055
Query: 1138 SDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGERLSEA-RDTEHKDREEL 1196
++ L G + + ++ T + + IT + EGG LS+A R E+ + +
Sbjct: 2056 TNQNSLAGGKNQGKVLIISTSTTNDYTPQVSAITDV--EGG---LSDALRTEENMEGTRV 2110
Query: 1197 SSRENRALKEGHRQDGEGALAAPEAEPAGKVQAPEGLIPATGQAEEL--------AAKDH 1248
++ E A + L A +E + E + +T EE K
Sbjct: 2111 TTEEFEAPMPSAVSGDDSQLTASRSE-----EKDECAMISTSIGEEFELPISSATTIKCA 2165
Query: 1249 DSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEEEDKECTLETEA 1308
+S + E + V++ T + E P+ + E+ +EE EC L + +
Sbjct: 2166 ESLQPVAAAVEERATGPVLISTADF---EGPMPSAPPEAESPLASTSKEEKDECALISTS 2222
Query: 1309 MQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEEREVLAGSETAEE 1368
+ + E + + G +NE G +E G G + ++ E+ E S +E
Sbjct: 2223 IAE---ECEASVSGVVVESENERAG----TVMEEKDGSGIISTSSVEDCEGPVSSAVPQE 2275
Query: 1369 K 1369
+
Sbjct: 2276 E 2276
Score = 36.6 bits (83), Expect = 0.19
Identities = 40/188 (21%), Positives = 82/188 (43%), Gaps = 15/188 (7%)
Query: 412 SRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVTA 471
S E + EK E+ K ++E + +I KR + K V ++ +VT
Sbjct: 2843 SSSETTGEKPEQNDDDTIKSQEEDQPIIIKRKRGRPRKYPVETTLKMKDDSKTDTGIVT- 2901
Query: 472 VEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPL 531
VE+ S K +V++ D+ N E ++ SN++G+ + + + +
Sbjct: 2902 VEQSPSSSK--LKVMQTDESNK---------ETANLQERSISNDDGEEKI-VTSVRRRGR 2949
Query: 532 DDKKDNL--DPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSSRSHP 589
K+ D + SE ++ D V+D+ + S+ E EE+++D + ++T S +
Sbjct: 2950 KPKRSLTVSDDAESSEPERKRQKSVSDPVEDKKEQESDEEEEEEEEDEPSGATTRSTTRS 3009
Query: 590 YSSDSEDE 597
+ S+ +
Sbjct: 3010 EAQRSKTQ 3017
Score = 35.8 bits (81), Expect = 0.33
Identities = 48/229 (20%), Positives = 92/229 (40%), Gaps = 8/229 (3%)
Query: 410 PKSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVV 469
P KE+++ EEL K + V+ +++E ++T+ + +E
Sbjct: 2807 PHDTKEENSRDLEELPKTSSETNSTTSRVMEEKDEYSSSETTGEKPEQNDDDTIKSQEED 2866
Query: 470 TAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQS 529
+ +G+P + +E + +K + + D + +Q S++ + +
Sbjct: 2867 QPIIIKRKRGRPRKYPVETTLK--MKDDSKTDTGIVTVEQSPSSSKLKVMQTDESNKETA 2924
Query: 530 PLDDKK-DNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSSRSH 588
L ++ N D E++ TS ++ +D SE E +Q K+ S
Sbjct: 2925 NLQERSISNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQ--KSVSDPVEDKK 2982
Query: 589 PYSSDSEDESAVGDRE--AHTDSSTDESARRSSSQELSENDKPRKSHLP 635
SD E+E D A T S+T A+RS +Q LS + K ++ P
Sbjct: 2983 EQESDEEEEEEEEDEPSGATTRSTTRSEAQRSKTQ-LSPSIKRKREVSP 3030
Score = 33.1 bits (74), Expect = 2.1
Identities = 44/214 (20%), Positives = 88/214 (41%), Gaps = 23/214 (10%)
Query: 907 EAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKR 966
E + +LE L + ++ + TS E + + S+ + E + D DT +
Sbjct: 2812 EENSRDLEELPKTSSETNSTTSRVMEEKDEYSSSETTGEKPEQNDD--------DTIKSQ 2863
Query: 967 EDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCK 1026
E+ ++ I+ + + RK + T ++ + S+ + E+ + + + +
Sbjct: 2864 EE--DQPIIIKRKRGRPRKYPVETTLKMK------DDSKTDTGIVTVEQSPSSSKLKVMQ 2915
Query: 1027 EDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTD---SEREEVTRA 1083
D +E E + +D E E + RR+ +PK SL +D S E R
Sbjct: 2916 TDESNKETANLQERSISNDDGE----EKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQ 2971
Query: 1084 NALKDEDAFKEEQKLKAEEGETETEVRAEEETKA 1117
++ D K+EQ+ EE E E + + T++
Sbjct: 2972 KSVSDPVEDKKEQESDEEEEEEEEDEPSGATTRS 3005
>gi|38176300 nestin [Homo sapiens]
Length = 1621
Score = 73.2 bits (178), Expect = 2e-12
Identities = 252/1168 (21%), Positives = 433/1168 (37%), Gaps = 260/1168 (22%)
Query: 415 EKSTEK--GEELKKAEGKVRKEREYVIPKRNE-----IKENKTSVSAKFSAQEIKTGLKE 467
EK T K GEE++++ + + + + N+ ++E+ ++ K +E K LK+
Sbjct: 542 EKETLKSLGEEIQESLKTLENQSHETLERENQECPRSLEEDLETL--KSLEKENKELLKD 599
Query: 468 VVT-------AVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQAD 520
V AV ++ GK + L+ Q+ + + ++ N+E +
Sbjct: 600 VEVVRPLEKEAVGQLKPTGKEDTQTLQSLQKENQELMKSLEGNLETFLFPGTENQELVSS 659
Query: 521 VQMNGIPQSPLDDKKDNLDPEKESETSSQKA--PDARDN------VKDENDGCSESELEE 572
+Q N + L+ K+N +P + E ++A P ++N ++DEN S +E
Sbjct: 660 LQENLESLTALE--KENQEPLRSPEVGDEEALRPLTKENQEPLRSLEDENKEAFRSLEKE 717
Query: 573 DKQDMKTASSTSSRSHPYSSDSEDESAVG--DREAHTDSSTDESARRSSSQELSENDKPR 630
+++ +KT + ED+S V + E H + E + + + L + + R
Sbjct: 718 NQEPLKTL------------EEEDQSIVRPLETENHKSLRSLEEQDQETLRTLEKETQQR 765
Query: 631 KSHLPIEESLEIEIEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGK 690
+ L ++ + + ++ V+ +P+ +S + + E QE + L E+S +
Sbjct: 766 RRSLGEQDQMTLRPPEK------VDLEPL---KSLDQEIARPLENENQEFLKSLKEESVE 816
Query: 691 HVSAEEKEKDKSKLWEESTAQVKDKKAGLPGLE--EGGKDSLPLAYVLALGAPTMNFMVD 748
V + E E +S K AG LE + + PL + MN +
Sbjct: 817 AVKSLETEILESL-----------KSAGQENLETLKSPETQAPLWTPEEINQGAMNPLEK 865
Query: 749 ETA----AINSNKESQQLVQK----------TYTLEKKEAMEEDEAPQHRDADIVQGKGE 794
E ++ N+E+ +L+++ + LE + EE + R+ + + G+
Sbjct: 866 EIQEPLESVEVNQETFRLLEEENQESLRSLGAWNLENLRSPEEVDKESQRNLEEEENLGK 925
Query: 795 AALWGEAGAVHE--------APLRAWKPTAEQP-ELAEEFTEKREIPPGIERGAEGAAEA 845
++ E A ++ W+ T E+ ELA+E PPG+ G E EA
Sbjct: 926 GEYQESLRSLEEEGQELPQSADVQRWEDTVEKDQELAQES------PPGMA-GVENEDEA 978
Query: 846 EGVRRLGEG--GSDPI---GQAAAKDAV---GLSKDEAPE-KQALMLTVLETDKAASEGE 896
E R +G G + + G+ A + V G E+PE K+ L + K +EG
Sbjct: 979 ELNLREQDGFTGKEEVVEQGELNATEEVWIPGEGHPESPEPKEQRGLVEGASVKGGAEGL 1038
Query: 897 QGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDT 956
Q E S++ A G A + E+ E D
Sbjct: 1039 QDPE-------------------------GQSQQVGAPGLQAPQGLPEAIEPLVED---- 1069
Query: 957 GPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEASRMQVSEGSPEEG 1016
D A + S E +LG E P GE+ A +E P +G
Sbjct: 1070 ----DVAPGGDQASPEVMLGSE-----------------PAMGESAAG----AEPGPGQG 1104
Query: 1017 --SLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTD 1074
L L +E+V E E++ E A+ + E P+ L +
Sbjct: 1105 VGGLGDPGHLTREEV--------MEPPLEEESLE--------AKRVQGLEGPRKDLEEAG 1148
Query: 1075 SEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPP-NEMGSDAENEAPVE 1133
E + K D ++ ++ + EE E E AEE A GSDA + P+
Sbjct: 1149 GLGTEFSELPG-KSRDPWEPPREGR-EESEAEAPRGAEEAFPAETLGHTGSDAPSPWPLG 1206
Query: 1134 ASELSDN-PGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGERLSEARDTEHKD 1192
+ E ++ P +L S T PI E PG + E + G + +EA +
Sbjct: 1207 SEEAEEDVPPVLVSPS--PTYTPILEDAPGPQPQAEG--SQEASWGVQGRAEALGKVESE 1262
Query: 1193 REELSSRENRALKEGHRQDGEGAL-------------------------AAPEAEPAGKV 1227
+EEL S E + EG +++GE + +P +P G+
Sbjct: 1263 QEELGSGE---IPEGPQEEGEESREESEEDELGETLPDSTPLGFYLRSPTSPRWDPTGEQ 1319
Query: 1228 QAP-------EGLIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQ-EAVAEEDP 1279
+ P EG PA +E L A + G EG E + G D L + E + E P
Sbjct: 1320 RPPPQGETGKEGWDPAVLASEGLEAPPSEKEEGEEG--EEECGRDSDLSEEFEDLGTEAP 1377
Query: 1280 IMAEKFRE--EAVDEDPEEEEDKECTLETEAMQDRNSEGDG-------DMEGEGNTQKNE 1330
+ E E + + P+ L A DR+ E DG EGE + ++
Sbjct: 1378 FLPGVPGEVAEPLGQVPQ-------LLLDPAAWDRDGESDGFADEEESGEEGEEDQEEGR 1430
Query: 1331 GMGGGRVVAVEVLHGGGETAETAAEEREVLAGSETAEEKTIANKASSFSDVAEEETWHQQ 1390
G GR G G + GS A + + V+ W
Sbjct: 1431 EPGAGR-------WGPGSSV-----------GSLQALSSSQRGEFLESDSVSVSVPW--D 1470
Query: 1391 DELVGKTAAAGKVVVEELARSGEEVPAAEEMTVTYTTEAGVGTPGALERKTSGLGQEQEE 1450
D L G A A K +E ++ E +EE + + E PG LE + E+
Sbjct: 1471 DSLRGAVAGAPKTALETESQDSAEPSGSEEESDPVSLEREDKVPGPLE-----IPSGMED 1525
Query: 1451 GSEGQEAATGSGDGRQETGAAEKFRLGL 1478
G + +G G G ++ G+
Sbjct: 1526 AGPGADIIGVNGQGPNLEGKSQHVNGGV 1553
Score = 54.3 bits (129), Expect = 9e-07
Identities = 163/750 (21%), Positives = 274/750 (36%), Gaps = 107/750 (14%)
Query: 776 EEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPEL-AEEFTEKREIPPG 834
++ E+ R I +G+GE +WG E + ++ Q E+ EE ++EI
Sbjct: 480 KDGESGGSRVFSICRGEGEGQIWGL--VEKETAIEGKVVSSLQQEIWEEEDLNRKEI--- 534
Query: 835 IERGAEGAAEAEGVRRLGEGGSDPIG--QAAAKDAVGLSKDEAPEKQALMLTVLETDKAA 892
+ ++ E E ++ LGE + + + + + + E P LE D
Sbjct: 535 --QDSQVPLEKETLKSLGEEIQESLKTLENQSHETLERENQECPRS-------LEED--- 582
Query: 893 SEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGESEEEASID 952
E + LEK N E L +V +R E EA G + + +++ S+
Sbjct: 583 LETLKSLEKE---------NKELLKDVEVVRPL----EKEAVGQLKPTGKEDTQTLQSLQ 629
Query: 953 LEDTGPMEDTASKRE------DGSEEAILGGEEP-------AKERKEVMRTETRLSPFTG 999
E+ M+ E ++E + +E KE +E +R SP G
Sbjct: 630 KENQELMKSLEGNLETFLFPGTENQELVSSLQENLESLTALEKENQEPLR-----SPEVG 684
Query: 1000 EAEASRMQVSEGSPEEGSLA---KEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDL 1056
+ EA R E SL KEAF E E + T E+D+ + P E +
Sbjct: 685 DEEALRPLTKENQEPLRSLEDENKEAFRSLEKENQEPLKT----LEEEDQSIVRPLETEN 740
Query: 1057 ARERRK-AERPKTSLRKTDSEREEVTRANALKDEDAFKEEQK-----LKAEEGETETEVR 1110
+ R E+ + +LR + E ++ R+ +D+ + +K LK+ + E +
Sbjct: 741 HKSLRSLEEQDQETLRTLEKETQQRRRSLGEQDQMTLRPPEKVDLEPLKSLDQEIARPLE 800
Query: 1111 AE-EETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLK--ETVVPIF---EATPGFE 1164
E +E E +A E E + G ++LK ET P++ E G
Sbjct: 801 NENQEFLKSLKEESVEAVKSLETEILESLKSAGQENLETLKSPETQAPLWTPEEINQGAM 860
Query: 1165 KSLENITALRKEGGGERLSEARDTEHKDREELSS-----RENRALKEGHRQDGEGALAAP 1219
LE E R E +++E L S EN L+ D E
Sbjct: 861 NPLEKEIQEPLESVEVNQETFRLLEEENQESLRSLGAWNLEN--LRSPEEVDKESQRNLE 918
Query: 1220 EAEPAGKVQAPEGLIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDP 1279
E E GK + E L + +EL A+ Q D V + QE E P
Sbjct: 919 EEENLGKGEYQESLRSLEEEGQELPQS-----------ADVQRWEDTVEKDQELAQESPP 967
Query: 1280 IMAEKFREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVA 1339
MA E+ + + E++ E + N+ + + GEG+ + E +V
Sbjct: 968 GMAGVENEDEAELNLREQDGFTGKEEVVEQGELNATEEVWIPGEGHPESPEPKEQRGLVE 1027
Query: 1340 VEVLHGG--------GETAETAAEEREVLAGSETAEEKTIANKASSFSDVAEEETWHQQD 1391
+ GG G++ + A + G A E + + + D A E +
Sbjct: 1028 GASVKGGAEGLQDPEGQSQQVGAPGLQAPQGLPEAIEPLVEDDVAPGGDQASPEVMLGSE 1087
Query: 1392 ELVGKTAA----------AGKVVVEELARSGEEVPAAEEMTVTYTTEAGVGTPGALERKT 1441
+G++AA G L R P EE ++ G+ P +
Sbjct: 1088 PAMGESAAGAEPGPGQGVGGLGDPGHLTREEVMEPPLEEESLEAKRVQGLEGPRKDLEEA 1147
Query: 1442 SGLGQE-QEEGSEGQEAATGSGDGRQETGA 1470
GLG E E + ++ +GR+E+ A
Sbjct: 1148 GGLGTEFSELPGKSRDPWEPPREGREESEA 1177
>gi|21493022 A kinase (PRKA) anchor protein 12 isoform 1 [Homo
sapiens]
Length = 1782
Score = 72.0 bits (175), Expect = 4e-12
Identities = 186/947 (19%), Positives = 350/947 (36%), Gaps = 142/947 (14%)
Query: 511 EKSNEEGQADVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESEL 570
++ + G D + Q P D + + ES SS + P E C E L
Sbjct: 532 KQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPEEP--------EEITCLEKGL 583
Query: 571 EEDKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARR-SSSQELSENDKP 629
E +QD + +S + + E + + RR S S + E DK
Sbjct: 584 AEVQQDGEAEEGATS-----DGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKV 638
Query: 630 RKSHLPIEESLEIEIEDQ-----EITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGL 684
+ + L ES E++++ E K + + + S+E ++ G+ K
Sbjct: 639 KSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSS 698
Query: 685 SEKSG-KHVSAEEKEKDKSKLWEESTAQVKDKKAGLPGLEEGGKDSLP---LAYVLALGA 740
E+ G K + + ++ D++ KDK+ G G+ G ++ P + G+
Sbjct: 699 DEEGGPKAMGGDHQKADEAG---------KDKETGTDGILAGSQEHDPGQGSSSPEQAGS 749
Query: 741 PTMNFMVDETAAINSNKESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGE 800
PT E +++ + ++LV P+ + ++ K E ++ G
Sbjct: 750 PT------EGEGVSTWESFKRLV----------------TPRKKSKSKLEEKSEDSIAG- 786
Query: 801 AGAVHEAPLRAWKPTAEQPELAEEFTE-KREIPPGIERGAEGAAEAEGVRRLGEGGSDPI 859
+G H P +P E + K+ IP ++ +G E V G G++
Sbjct: 787 SGVEHSTP-------DTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANE- 838
Query: 860 GQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEV 919
+ V LS+ +A E++ + E +A EQ +KA + L+ +H +
Sbjct: 839 DDSDVPAVVPLSEYDAVEREKM-----EAQQAQKSAEQPEQKAA-TEVSKELSESQVHMM 892
Query: 920 AALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPME----DTASKREDGSEEAIL 975
AA G + + E + I T P+E + A E+ E ++
Sbjct: 893 AAA----------VADGTRAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVI 942
Query: 976 GGEEPA----------KERKEVMRTETRLSPFTGEAEASRMQVSEGSPEEGSLAKEAFLC 1025
EEP + R + + +E L+P EA + EEG+ A A
Sbjct: 943 AEEEPPTVTEPLPENREARGDTVVSEAELTP---EAVTAAETAGPLGAEEGTEASAAEET 999
Query: 1026 KEDVEGEEMVTEAEANREDDR--KEILPKELDLARERRKAERPKTSLRKTDSEREEVTRA 1083
E V +T++ E+ +E+ D+ + R+ + ++ + E ++
Sbjct: 1000 TEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGT 1059
Query: 1084 NALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEASELSDNPGL 1143
ED + Q+ +AE R EE+ +A + + + + V+A E P
Sbjct: 1060 GG--PEDVLQPVQRAEAE--------RPEEQAEA--SGLKKETDVVLKVDAQEAKTEPFT 1107
Query: 1144 LGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGERLSEARDTEHKDREELSSRENRA 1203
G+ + +T FE P +S+E+ SE T E L+ +++
Sbjct: 1108 QGK-VVGQTTPESFEKAPQVTESIES-------------SELVTT--CQAETLAGVKSQE 1151
Query: 1204 LKEGHRQDGEGALAAPEAEPAGKVQAPEGLIPATGQAEELAAKDHDSCAGLEGRAEGQGG 1263
+ + ++E G + P T Q +E+ ++ ++ G
Sbjct: 1152 MVMEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEA 1211
Query: 1264 VDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGDMEGE 1323
V + + A + E+ +E++ ED E DKE ++ET ++ + +EG + +
Sbjct: 1212 EAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSILSK-TEGTQEADQY 1270
Query: 1324 GNTQKNEGMGGGRVVAVEVLHGGGETAETAAEER---EVLAGSETAEEKTIANKASSFSD 1380
+ + + V E L G +T T + E+ L G T E + + A
Sbjct: 1271 ADEKTKD------VPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDALELQS 1324
Query: 1381 VAEEETWHQQDELV-----GKTAAAGKVVVEELARSGEEVPAAEEMT 1422
A+ + E+V KT A V EE V +EE++
Sbjct: 1325 HAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHETAVTVSEEVS 1371
Score = 63.5 bits (153), Expect = 1e-09
Identities = 219/1058 (20%), Positives = 379/1058 (35%), Gaps = 154/1058 (14%)
Query: 539 DPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSSRSHPYSSDSEDE- 597
DP + + K + N + EL + D+ + +S E+E
Sbjct: 43 DPAIAASDPATKLLQKNGQLSTINGVAEQDELSLQEGDLNGQKGALNGQGALNSQEEEEV 102
Query: 598 --SAVGDREAHTDSSTD---ESARRSSSQELSENDKPRKSHLPIEESLEIEIEDQEITKA 652
+ VG R++ S D E A +S+ +D ++ IE+ E +E+T+
Sbjct: 103 IVTEVGQRDSEDVSKRDSDKEMATKSAVVHDITDDGQEETPEIIEQIPSSESNLEELTQP 162
Query: 653 DVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSKLWEESTAQV 712
T+ D F+ V K K T + + +EK V +KD+ E A
Sbjct: 163 ---TESQANDIGFKKVFKFVGFKFT--VKKDKTEKPDT-VQLLTVKKDEG----EGAAGA 212
Query: 713 KDKK-AGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDET-AAINSNKESQQLVQKTYTL- 769
D K L E K+S P + P +++ A I+ ES Q V++
Sbjct: 213 GDHKDPSLGAGEAASKESEPKQ---STEKPEETLKREQSHAEISPPAESGQAVEECKEEG 269
Query: 770 EKKEAMEEDEAPQHRDADIVQGKGEAA----LWGEAGAVHEAPLRAWKPTAEQPELAEEF 825
E+K+ E ++ + + + G G AG + R KP ++ E +E+
Sbjct: 270 EEKQEKEPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFR--KPKEDEVEASEK- 326
Query: 826 TEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTV 885
+K + P ++ +G AE + + P A + LS + EK L
Sbjct: 327 -KKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQEPAESAHEPRLSAEY--EKVELPS-- 381
Query: 886 LETDKAASEGEQGLEKAVLANEAAALNLE-HLHEVAALREAATSEEGEAEGGVAVSDVGE 944
E + S+G + A LA E +E H EV A +T EE E V +
Sbjct: 382 -EEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVEETAG 440
Query: 945 SEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEP------------------------ 980
S + D P E +K +E + GE+P
Sbjct: 441 SVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEV 500
Query: 981 ----AKERKEV-------MRTETRLSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDV 1029
++ER +V + T T L +G+ + + G +E S
Sbjct: 501 EMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGK----RGGGDEESGEHTQVPADSPD 556
Query: 1030 EGEEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEVTRANALKDE 1089
EE E+ A+ ++ +EI E LA ++ E + + + +RE VT + K
Sbjct: 557 SQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKM 616
Query: 1090 DAFKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEASE-LSDNPGLLGEDS 1148
K+ + +E + + + + T + S+ + E E + P + S
Sbjct: 617 VTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTS 676
Query: 1149 LK-ETVVPIFEATPGFEKSLENITALRKEGGGERLS---EARDTEHKDREELSSRENRAL 1204
+ E ++ + + +K ++ +EGG + + + D KD+E + +
Sbjct: 677 VSWEALICVGSS----KKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKE--TGTDGILA 730
Query: 1205 KEGHRQDGEGALAAPEAEPAGKVQAPEG----------LIPATGQAEELAAKDHDSCAGL 1254
G+G + E AG EG + P +L K DS AG
Sbjct: 731 GSQEHDPGQG---SSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAG- 786
Query: 1255 EGRAEGQGGVDVVLRTQEAVAEEDPIMAEKF------------REEAVDEDP----EEEE 1298
GV+ E EE + +KF +E+A ED E+
Sbjct: 787 -------SGVEHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANED 839
Query: 1299 DKEC----------TLETEAMQDRNSEGDGDM-EGEGNTQKNEGMGGGRVVAVEVLHGGG 1347
D + +E E M+ + ++ + E + T+ ++ + +V + G
Sbjct: 840 DSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADG 899
Query: 1348 ETAETAAEEREV--LAGSETAEEKTIANKASSFSD-------VAEEETWHQQDELVGKTA 1398
A T EER ++ S T + + +A+ ++ +AEEE + L
Sbjct: 900 TRAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENRE 959
Query: 1399 AAGKVVVEELARSGEEVPAAEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEGSEGQEAA 1458
A G VV E + E V AAE G GA E + +E E
Sbjct: 960 ARGDTVVSEAELTPEAVTAAET----------AGPLGAEEGTEASAAEETTEMVSAVSQL 1009
Query: 1459 TGSGDGRQETGAAEKFRLGLSREGERE-LSPESLQAMA 1495
T S D +E ++ G+ E+E + E LQA+A
Sbjct: 1010 TDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVA 1047
Score = 32.7 bits (73), Expect = 2.8
Identities = 43/195 (22%), Positives = 72/195 (36%), Gaps = 21/195 (10%)
Query: 411 KSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTG------ 464
K +E +E K E V ++I ++ + S K E++
Sbjct: 1596 KEGEEPQASAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQ 1655
Query: 465 LKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMN 524
L+EVV EE G + V EDD L E+ E K+ EK ++ + Q +
Sbjct: 1656 LEEVVLPSEE-EGGGAGTKSVPEDDGHALLAERIEKSLV--EPKEDEKGDDVDDPENQNS 1712
Query: 525 GIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTS 584
+ + D L E +PD + E + E EL+E K ++ + +
Sbjct: 1713 ALADT---DASGGLTKE---------SPDTNGPKQKEKEDAQEVELQEGKVHSESDKAIT 1760
Query: 585 SRSHPYSSDSEDESA 599
++ E ESA
Sbjct: 1761 PQAQEELQKQERESA 1775
>gi|21493024 A kinase (PRKA) anchor protein 12 isoform 2 [Homo
sapiens]
Length = 1684
Score = 72.0 bits (175), Expect = 4e-12
Identities = 186/947 (19%), Positives = 350/947 (36%), Gaps = 142/947 (14%)
Query: 511 EKSNEEGQADVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESEL 570
++ + G D + Q P D + + ES SS + P E C E L
Sbjct: 434 KQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPEEP--------EEITCLEKGL 485
Query: 571 EEDKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARR-SSSQELSENDKP 629
E +QD + +S + + E + + RR S S + E DK
Sbjct: 486 AEVQQDGEAEEGATS-----DGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKV 540
Query: 630 RKSHLPIEESLEIEIEDQ-----EITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGL 684
+ + L ES E++++ E K + + + S+E ++ G+ K
Sbjct: 541 KSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSS 600
Query: 685 SEKSG-KHVSAEEKEKDKSKLWEESTAQVKDKKAGLPGLEEGGKDSLP---LAYVLALGA 740
E+ G K + + ++ D++ KDK+ G G+ G ++ P + G+
Sbjct: 601 DEEGGPKAMGGDHQKADEAG---------KDKETGTDGILAGSQEHDPGQGSSSPEQAGS 651
Query: 741 PTMNFMVDETAAINSNKESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGE 800
PT E +++ + ++LV P+ + ++ K E ++ G
Sbjct: 652 PT------EGEGVSTWESFKRLV----------------TPRKKSKSKLEEKSEDSIAG- 688
Query: 801 AGAVHEAPLRAWKPTAEQPELAEEFTE-KREIPPGIERGAEGAAEAEGVRRLGEGGSDPI 859
+G H P +P E + K+ IP ++ +G E V G G++
Sbjct: 689 SGVEHSTP-------DTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANE- 740
Query: 860 GQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEV 919
+ V LS+ +A E++ + E +A EQ +KA + L+ +H +
Sbjct: 741 DDSDVPAVVPLSEYDAVEREKM-----EAQQAQKSAEQPEQKAA-TEVSKELSESQVHMM 794
Query: 920 AALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPME----DTASKREDGSEEAIL 975
AA G + + E + I T P+E + A E+ E ++
Sbjct: 795 AAA----------VADGTRAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVI 844
Query: 976 GGEEPA----------KERKEVMRTETRLSPFTGEAEASRMQVSEGSPEEGSLAKEAFLC 1025
EEP + R + + +E L+P EA + EEG+ A A
Sbjct: 845 AEEEPPTVTEPLPENREARGDTVVSEAELTP---EAVTAAETAGPLGAEEGTEASAAEET 901
Query: 1026 KEDVEGEEMVTEAEANREDDR--KEILPKELDLARERRKAERPKTSLRKTDSEREEVTRA 1083
E V +T++ E+ +E+ D+ + R+ + ++ + E ++
Sbjct: 902 TEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGT 961
Query: 1084 NALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEASELSDNPGL 1143
ED + Q+ +AE R EE+ +A + + + + V+A E P
Sbjct: 962 GG--PEDVLQPVQRAEAE--------RPEEQAEA--SGLKKETDVVLKVDAQEAKTEPFT 1009
Query: 1144 LGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGERLSEARDTEHKDREELSSRENRA 1203
G+ + +T FE P +S+E+ SE T E L+ +++
Sbjct: 1010 QGK-VVGQTTPESFEKAPQVTESIES-------------SELVTT--CQAETLAGVKSQE 1053
Query: 1204 LKEGHRQDGEGALAAPEAEPAGKVQAPEGLIPATGQAEELAAKDHDSCAGLEGRAEGQGG 1263
+ + ++E G + P T Q +E+ ++ ++ G
Sbjct: 1054 MVMEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEA 1113
Query: 1264 VDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGDMEGE 1323
V + + A + E+ +E++ ED E DKE ++ET ++ + +EG + +
Sbjct: 1114 EAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSILSK-TEGTQEADQY 1172
Query: 1324 GNTQKNEGMGGGRVVAVEVLHGGGETAETAAEER---EVLAGSETAEEKTIANKASSFSD 1380
+ + + V E L G +T T + E+ L G T E + + A
Sbjct: 1173 ADEKTKD------VPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDALELQS 1226
Query: 1381 VAEEETWHQQDELV-----GKTAAAGKVVVEELARSGEEVPAAEEMT 1422
A+ + E+V KT A V EE V +EE++
Sbjct: 1227 HAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHETAVTVSEEVS 1273
Score = 60.5 bits (145), Expect = 1e-08
Identities = 205/985 (20%), Positives = 354/985 (35%), Gaps = 158/985 (16%)
Query: 620 SQELSENDKPRKSHLPIEESLEIEIEDQEITKADVETKPMPIDESFENVLKEGTEKGTQE 679
S+++S+ D ++ +I + QE T +E +P ES L + TE +
Sbjct: 14 SEDVSKRDSDKEMATKSAVVHDITDDGQEETPEIIEQ--IPSSESNLEELTQPTESQAND 71
Query: 680 IAEGLSEKSGKHVSAEEKEKDKSKLWEESTAQV----KDKKAGLPGL-----------EE 724
I +K K V + K K K + T Q+ KD+ G G E
Sbjct: 72 IG---FKKVFKFVGFKFTVK-KDKTEKPDTVQLLTVKKDEGEGAAGAGDHKDPSLGAGEA 127
Query: 725 GGKDSLPLAYVLALGAPTMNFMVDET-AAINSNKESQQLVQKTYTL-EKKEAMEEDEAPQ 782
K+S P + P +++ A I+ ES Q V++ E+K+ E ++ +
Sbjct: 128 ASKESEPKQ---STEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAE 184
Query: 783 HRDADIVQGKGEAA----LWGEAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERG 838
+ + G G AG + R KP ++ E +E+ +K + P ++
Sbjct: 185 SPTSPVTSETGSTFKKFFTQGWAGWRKKTSFR--KPKEDEVEASEK--KKEQEPEKVDTE 240
Query: 839 AEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQG 898
+G AE + + P A + LS + EK L E + S+G
Sbjct: 241 EDGKAEVASEKLTASEQAHPQEPAESAHEPRLSAEY--EKVELPS---EEQVSGSQGPSE 295
Query: 899 LEKAVLANEAAALNLE-HLHEVAALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTG 957
+ A LA E +E H EV A +T EE E V + S + D
Sbjct: 296 EKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVEETAGSVPAEELVEMDAE 355
Query: 958 PMEDTASKREDGSEEAILGGEEP----------------------------AKERKEV-- 987
P E +K +E + GE+P ++ER +V
Sbjct: 356 PQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSSQERMKVQG 415
Query: 988 -----MRTETRLSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANR 1042
+ T T L +G+ + + G +E S EE E+ A+
Sbjct: 416 SPLKKLFTSTGLKKLSGKKQKGK----RGGGDEESGEHTQVPADSPDSQEEQKGESSASS 471
Query: 1043 EDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEE 1102
++ +EI E LA ++ E + + + +RE VT + K K+ + +E
Sbjct: 472 PEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSES 531
Query: 1103 GETETEVRAEEETKAPPNEMGSDAENEAPVEASE-LSDNPGLLGEDSLK-ETVVPIFEAT 1160
+ + + + T + S+ + E E + P + S+ E ++ + +
Sbjct: 532 DKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSS- 590
Query: 1161 PGFEKSLENITALRKEGGGERLS---EARDTEHKDREELSSRENRALKEGHRQDGEGALA 1217
+K ++ +EGG + + + D KD+E + + G+G
Sbjct: 591 ---KKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKE--TGTDGILAGSQEHDPGQG--- 642
Query: 1218 APEAEPAGKVQAPEG----------LIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVV 1267
+ E AG EG + P +L K DS AG GV+
Sbjct: 643 SSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAG--------SGVEHS 694
Query: 1268 LRTQEAVAEEDPIMAEKF------------REEAVDEDP----EEEEDKEC--------- 1302
E EE + +KF +E+A ED E+D +
Sbjct: 695 TPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEY 754
Query: 1303 -TLETEAMQDRNSEGDGDM-EGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEEREV- 1359
+E E M+ + ++ + E + T+ ++ + +V + G A T EER
Sbjct: 755 DAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPS 814
Query: 1360 -LAGSETAEEKTIANKASSFSD-------VAEEETWHQQDELVGKTAAAGKVVVEELARS 1411
++ S T + + +A+ ++ +AEEE + L A G VV E +
Sbjct: 815 WISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEAELT 874
Query: 1412 GEEVPAAEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEGSEGQEAATGSGDGRQETGAA 1471
E V AAE G GA E + +E E T S D +E
Sbjct: 875 PEAVTAAET----------AGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPV 924
Query: 1472 EKFRLGLSREGERE-LSPESLQAMA 1495
++ G+ E+E + E LQA+A
Sbjct: 925 QEVEGGVPDIEEQERRTQEVLQAVA 949
Score = 32.7 bits (73), Expect = 2.8
Identities = 43/195 (22%), Positives = 72/195 (36%), Gaps = 21/195 (10%)
Query: 411 KSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTG------ 464
K +E +E K E V ++I ++ + S K E++
Sbjct: 1498 KEGEEPQASAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQ 1557
Query: 465 LKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMN 524
L+EVV EE G + V EDD L E+ E K+ EK ++ + Q +
Sbjct: 1558 LEEVVLPSEE-EGGGAGTKSVPEDDGHALLAERIEKSLV--EPKEDEKGDDVDDPENQNS 1614
Query: 525 GIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTS 584
+ + D L E +PD + E + E EL+E K ++ + +
Sbjct: 1615 ALADT---DASGGLTKE---------SPDTNGPKQKEKEDAQEVELQEGKVHSESDKAIT 1662
Query: 585 SRSHPYSSDSEDESA 599
++ E ESA
Sbjct: 1663 PQAQEELQKQERESA 1677
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 71.2 bits (173), Expect = 7e-12
Identities = 234/1210 (19%), Positives = 445/1210 (36%), Gaps = 180/1210 (14%)
Query: 406 KPSLPKSRKEKSTE-KGEEL---KKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEI 461
KP L +R+E+ + K EEL K+ + KV E E + K ++ E K ++ + A+
Sbjct: 842 KPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAET- 900
Query: 462 KTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADV 521
E+ EEM ++ ++ LE+ + ++ E E +EE+ NE+ +
Sbjct: 901 -----ELFAEAEEMRARLAAKKQELEE-----ILHDLESRVEEEEERNQILQNEKKKMQA 950
Query: 522 QMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNV---KDENDG-------------- 564
+ + + +++ + E T+ K + + +D+N
Sbjct: 951 HIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAE 1010
Query: 565 CSESELEEDKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELS 624
CS S+L E+++ K + ++ SD E+ +E T +++ R+ +
Sbjct: 1011 CS-SQLAEEEEKAKNLAKIRNKQEVMISDLEERLK---KEEKTRQELEKAKRKLDGETTD 1066
Query: 625 ENDKPRKSHLPIEE-SLEIEIEDQEITKADVETKPMPIDESFENVLKEGTEKGTQ--EIA 681
D+ + I+E L++ +++E+ A + ++ N LK E Q E+
Sbjct: 1067 LQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKN--NALKVVRELQAQIAELQ 1124
Query: 682 EGLSEKSGKHVSAEEKEKDKSKLWEESTAQVKDKKAGLPGLEE--GGKDSLPLAYVLALG 739
E + AE++++D S+ E +++D +E ++ AL
Sbjct: 1125 EDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALE 1184
Query: 740 APTMNFMVD--------ETAAINSNKESQQLVQKTYTLEK-KEAMEEDEAPQHRDADIVQ 790
T N TA +++ +Q + LEK K+ +E D + ++Q
Sbjct: 1185 EETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQ 1244
Query: 791 ---GKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAEGAAEAEG 847
+ E V E + + + ELAE+ ++ + + E AE +G
Sbjct: 1245 QVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLE-EAEKKG 1303
Query: 848 VRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTV--LETDKAA--------SEGEQ 897
++ + S ++ +D L ++E +K L + LE +K + E +
Sbjct: 1304 IKFAKDAASL---ESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARK 1360
Query: 898 GLEKAVLANEAAALNL-----EHLHEVAALREAATSEEGEAEGGVAVSDVGESEEEASID 952
LEK VLA ++ + + L + +L EA +AE A+S E + A
Sbjct: 1361 NLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAE---ALSQRLEEKALAYDK 1417
Query: 953 LEDTGPME----DTASKREDGSEEAILGGEEPAKERKEVMRTETRLSP-FTGEAEASRMQ 1007
LE T D + D + E+ K+ +++ E +S + E + + +
Sbjct: 1418 LEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAE 1477
Query: 1008 VSEGSPEEGSLAK---EAFLCKEDVEGEEMVTEAE-----ANREDDRKEILPKELDLARE 1059
E + SLA+ EA KE+ E + A+ ++++D K + E
Sbjct: 1478 AREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRAL 1537
Query: 1060 RRKAERPKTSLRKTDSEREEVTRANA----------------LKDEDAFKEEQKLKAEEG 1103
++ E +T L + + E + A L+ D EE+K +
Sbjct: 1538 EQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQ 1597
Query: 1104 ETETEVRAEEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGF 1163
E E E+E K + S + E ++ E D + + + + +
Sbjct: 1598 VRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDY 1657
Query: 1164 EKSLENITALRKEGGGERLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEP 1223
++ LE A R E + + + + E L +E A E R+ E
Sbjct: 1658 QRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAE---------- 1707
Query: 1224 AGKVQAPEGLIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEED----P 1279
+ +ELA + +S +G + + ++ + E EE+
Sbjct: 1708 --------------QERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNME 1753
Query: 1280 IMAEKFREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGD----------MEGEGNTQKN 1329
++ ++FR+ + D TL E +R++ D E + Q+
Sbjct: 1754 LLNDRFRKTTLQVD---------TLNAELAAERSAAQKSDNARQQLERQNKELKAKLQEL 1804
Query: 1330 EGMGGGRVVA-VEVLHGG-GETAETAAEEREVLAGSETAEEKTIANKASSFSDVAEEETW 1387
EG + A + L G+ E +E + A + +T F V E+E
Sbjct: 1805 EGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQV-EDERR 1863
Query: 1388 H--QQDELVGKTAAAGKVVVEELARSGEEVPAAEEMTVTYTTEAGVGTPGALERKTSGLG 1445
H Q E + K A K + +L + EE A A RK
Sbjct: 1864 HADQYKEQMEKANARMKQLKRQLEEAEEEATRA----------------NASRRKLQREL 1907
Query: 1446 QEQEEGSEGQEAATGSGDGRQETGAAEKFRLGLSREGERELSPESLQAMATLPVKPDFTE 1505
+ E +EG + R G F SR G R+L E A+L + D TE
Sbjct: 1908 DDATEANEGLSREVSTLKNRLRRGGPISF--SSSRSGRRQLHLEG----ASLELSDDDTE 1961
Query: 1506 TREKQQHMVQ 1515
++ + Q
Sbjct: 1962 SKTSDVNETQ 1971
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 70.5 bits (171), Expect = 1e-11
Identities = 189/939 (20%), Positives = 345/939 (36%), Gaps = 94/939 (10%)
Query: 405 KKPSLPKSRKEKSTE--KGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIK 462
++ L + ++E+ + K EE+++ E + R+E+ KR E +E + K QE +
Sbjct: 586 RQQRLKREQEERLEQRLKREEVERLEQEERREQRL---KREEPEEERRQQLLKSEEQEER 642
Query: 463 TGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQ 522
++ + ++ + + +E E+ E LK E+EE E E++ E+ E+ + ++
Sbjct: 643 R--QQQLRREQQERREQRLKREEEEERLEQRLKREHEE--ERREQELAEEEQEQARERIK 698
Query: 523 MNGIP--QSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESEL---EEDKQDM 577
IP Q L+ + D + S Q+ R ++E ESEL EE++
Sbjct: 699 SR-IPKWQWQLESEADARQSKVYSRPRKQEGQRRRQE-QEEKRRRRESELQWQEEERAHR 756
Query: 578 KTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIE 637
+ R + +E++S G + E R E E + + LP E
Sbjct: 757 QQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAE--ERQQREQRFLPEE 814
Query: 638 ESLEIEIEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEK 697
E E Q + K + E E + + + QE +GL E + S E++
Sbjct: 815 EEKE-----QRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQR 869
Query: 698 EKDKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNK 757
+D+ W+ LEE K Y + A +
Sbjct: 870 -RDQKWRWQ---------------LEEERKRRRHTLYA-------------KPALQEQLR 900
Query: 758 ESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAE 817
+ QQL+Q+ E++E E+ + R Q + E L E E LR +
Sbjct: 901 KEQQLLQE----EEEELQREEREKRRRQEQERQYREEEQLQQE----EEQLLREEREKRR 952
Query: 818 QPELAEEFTEKREIPPGIER--GAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEA 875
+ E ++ + +++ E+ G E R + + Q ++ + + E
Sbjct: 953 RQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQE--EEQLLREEREK 1010
Query: 876 PEKQALMLTVLETDKAASEGEQGL----EKAVLANEAAALNLEHLHEVAALREAATSEEG 931
+Q + D+ E EQ L EK L E E+ E EE
Sbjct: 1011 RRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEE--ELQQEEEQLLGEER 1068
Query: 932 EAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTE 991
E + EEE + E+ + + KR E EE ++ +E + E
Sbjct: 1069 ETRRRQELERQYRKEEE--LQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLRE 1126
Query: 992 TRLSPFTGEAEASRMQVSEGSPEEGSLAKEA------------FLCKEDVEGEE--MVTE 1037
R E E + E EE L +E + +E+++ EE ++ E
Sbjct: 1127 EREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLRE 1186
Query: 1038 AEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQK 1097
+ R +R+ +E +L R++RK R + E + NA++D + + ++
Sbjct: 1187 EQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRE 1246
Query: 1098 LKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIF 1157
+ ++++R + + + +G E + E E+ E
Sbjct: 1247 NEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQ-K 1305
Query: 1158 EATPGFEKSLENITALRKEGGGERLSEARDTEHKDREE-LSSRENRALKEGHRQDGEGAL 1216
EA KS E LR+E +R + D + ++ E+ L RE + L+ RQ+ +
Sbjct: 1306 EAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLR---RQERDRKF 1362
Query: 1217 AAPEA--EPAGKVQAPEGLIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAV 1274
E + G+ E + E K+ E + + D R +E
Sbjct: 1363 REEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQ 1422
Query: 1275 AEEDPIMAEKFREEAVDEDPEEEEDKECTLETEAMQDRN 1313
KFREE +E E K E + Q+R+
Sbjct: 1423 LSRQE-RDRKFREEEQQVRRQERERKFLEEEQQLRQERH 1460
Score = 63.2 bits (152), Expect = 2e-09
Identities = 212/1074 (19%), Positives = 387/1074 (36%), Gaps = 160/1074 (14%)
Query: 411 KSRKEKSTEKGEELKKAEGKV-RKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVV 469
+ +E+ + E+L++ E ++ R+ERE +R + +E + K +E + +E
Sbjct: 923 RQEQERQYREEEQLQQEEEQLLREERE---KRRRQERERQYRKDKKLQQKEEQLLGEEPE 979
Query: 470 TAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQM--NGIP 527
+ K +E L+ ++E L+ E E+ + E+Q K +E Q + Q+
Sbjct: 980 KRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREERE 1039
Query: 528 QSPLDDKKDNLDPEKESETSSQKA----PDARDNVKDENDGCSESELEEDKQDMKTASST 583
+ L +++ E+E + ++ + R + E E EL+++++ +
Sbjct: 1040 KRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPE 1099
Query: 584 SSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEESLEIE 643
R +E + E E RR QEL + + EE L E
Sbjct: 1100 KRRRQERERQCREEEELQQEEEQLLREEREKRRR---QELERQYREEEEVQQEEEQLLRE 1156
Query: 644 IED----QEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEK 699
+ QE+ + E + + +E E +L+E EK QE + ++ EE ++
Sbjct: 1157 EPEKRRRQELERQYREEEELQQEE--EQLLREEQEKRRQE-------RERQYREEEELQR 1207
Query: 700 DKSKLWEESTAQVKDKK-AGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKE 758
K K Q D K P E +D+ V G F E + + +
Sbjct: 1208 QKRKQRYRDEDQRSDLKWQWEPEKENAVRDNK----VYCKGRENEQFRQLEDSQLRDRQS 1263
Query: 759 SQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQ 818
Q L ++++ +E Q RD P EQ
Sbjct: 1264 QQDLQHLLGEQQERDREQERRRWQQRDRHF-------------------------PEEEQ 1298
Query: 819 PELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEK 878
E E+ KR +++ L ++E EK
Sbjct: 1299 LEREEQKEAKRR------------------------------DRKSQEEKQLLREEREEK 1328
Query: 879 QALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVA 938
+ ETD+ E EQ L++ E L + E E+G
Sbjct: 1329 RRRQ----ETDRKFREEEQLLQE----REEQPLRRQERDRKFREEELRHQEQGR------ 1374
Query: 939 VSDVGESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFT 998
+ E + + E E+ + ++ ++ + +E ++ + + R F
Sbjct: 1375 -KFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFR 1433
Query: 999 GEAEASRMQVSEGS--PEEGSLAKEAFLCKEDVEGEEMVTEAEA---NREDDRKEILPKE 1053
E + R Q E EE L +E ++ E E+++ E E +R++ ++ L +E
Sbjct: 1434 EEEQQVRRQERERKFLEEEQQLRQERH--RKFREEEQLLQEREEQQLHRQERDRKFLEEE 1491
Query: 1054 LDLARERRKAERPKTSLRKTDSEREEVTRANAL----KDEDAFKEEQKLKAEEGETETEV 1109
L R+ R + + LR + ER+ + L + +EEQ+L+ +E +
Sbjct: 1492 QQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQR-- 1549
Query: 1110 RAEEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLEN 1169
R + + K E E + E D L E ++ K +E+
Sbjct: 1550 RQDRDRKFREEEQLRQEREEQQLSRQE-RDRKFRLEEQKVRRQEQE--------RKFMED 1600
Query: 1170 ITALRKEGGGERLSEARDTEHKDREE-LSSRENRALKEGHRQDGEGALAAPEAEPAGKVQ 1228
LR++ G ++L + RD + ++ E+ L RE + L HRQ+ + E EP + Q
Sbjct: 1601 EQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQL---HRQERDRKFL--EEEPQLRRQ 1655
Query: 1229 APEGLIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREE 1288
+ E+ D D E + Q G + LR QE KFREE
Sbjct: 1656 ----------EREQQLRHDRDRKFREEEQLL-QEGEEQQLRRQE--------RDRKFREE 1696
Query: 1289 AVDEDPEEEEDK----ECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLH 1344
+E E K E L + ++ + E + + Q +++ E L
Sbjct: 1697 EQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLR 1756
Query: 1345 GGGETAETAAEEREVLAGSE-----TAEEKTIANKASSFSDVAEEETWHQQDE-LVGKTA 1398
E + +ER+ E EE+ + ++ S EE+ +++E +
Sbjct: 1757 PEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQ 1816
Query: 1399 AAGKVVVEE--LARSGEEVPAAEEMTVTYTTEAGVGTPGALERKTSGLGQEQEE 1450
GK EE L +E +E Y E T R+ L QE+E+
Sbjct: 1817 RDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQ 1870
Score = 59.7 bits (143), Expect = 2e-08
Identities = 178/995 (17%), Positives = 360/995 (36%), Gaps = 132/995 (13%)
Query: 402 GLDKKPSLPKSRKEK--STEKGEELKKAEGKVRKEREYVI---PKRNEIKENKTSVSAKF 456
G ++K + R+++ E+ +E +K E +RKE E + P+R + + K
Sbjct: 222 GREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKL 281
Query: 457 SAQEIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEE 516
QE++ +E EE Q+ L +Q+ K E EE E EE++ ++ E
Sbjct: 282 ERQELRRERQE-----EEQQ------QQRLRREQQLRRKQE-EERREQQEERREQQERRE 329
Query: 517 GQADVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEED--- 573
Q + + + + + ++ L E+E E Q+ ++ + E E +L +
Sbjct: 330 QQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQL 389
Query: 574 --------------------------------KQDMKTASSTSSRSHPYSSDSEDESAVG 601
+Q ++ + + ++
Sbjct: 390 RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKR 449
Query: 602 DREAHTD-------SSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIEDQEITKADV 654
++E D + E RR + + ++ R+ L +EE E E QE + +
Sbjct: 450 EQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEE--EERREQQERREQQL 507
Query: 655 ETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSKLWEESTAQVKD 714
+ +E E LK E+ + + + L + EE+ + K EE + +
Sbjct: 508 RREQ---EERREQRLKRQEEE--ERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQER 562
Query: 715 KKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQKTYTLEKKEA 774
++ L +E +D L +E +E ++ +++ E+ E
Sbjct: 563 REQRLKREQEERRDQLLK-------------REEERRQQRLKREQEERLEQRLKREEVER 609
Query: 775 MEEDEAPQHR--DADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEFTEKREIP 832
+E++E + R + + + + L E + R + EQ E E+ ++ E
Sbjct: 610 LEQEERREQRLKREEPEEERRQQLLKSE----EQEERRQQQLRREQQERREQRLKREEEE 665
Query: 833 PGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSK------DEAPEKQALMLTVL 886
+E+ + E E RR E + QA + + K EA +Q+ +
Sbjct: 666 ERLEQRLKREHEEE--RREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVY--- 720
Query: 887 ETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSE-------EGEAEGGVAV 939
+ EG++ ++ L+ E A R+ E + +AE
Sbjct: 721 -SRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAE---EK 776
Query: 940 SDVGESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTG 999
S+ G A L + + A +R+ E+ L EE ++R+ R + F
Sbjct: 777 SERGRQRLSARPPLREQRERQLRAEERQQ-REQRFLPEEEEKEQRRRQRREREKELQFLE 835
Query: 1000 EAE--ASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLA 1057
E E R + + EE L ++ + + + + E R+
Sbjct: 836 EEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPAL 895
Query: 1058 RERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKA 1117
+E+ + E+ + + +REE + + E ++EE++L+ EE + E R + +
Sbjct: 896 QEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQE 955
Query: 1118 PPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEG 1177
+ D + + E L + P ++ E E+ L R+
Sbjct: 956 RERQYRKDKKLQQK-EEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQ 1014
Query: 1178 GGERLSEARDTEHKDREEL--SSRENRALKEGHRQDGEGALAAPEAEPAGKVQAPEGLIP 1235
ER +D ++ E+L RE R L+E RQ E ++Q E
Sbjct: 1015 EWERQYRKKDELQQEEEQLLREEREKRRLQERERQYRE----------EEELQQEE---- 1060
Query: 1236 ATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPE 1295
E+L ++ ++ E + + ++ ++ + EE + RE E+ E
Sbjct: 1061 -----EQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEE 1115
Query: 1296 EEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNE 1330
++++E L E + R E + E Q+ E
Sbjct: 1116 LQQEEEQLLREEREKRRRQELERQYREEEEVQQEE 1150
Score = 56.6 bits (135), Expect = 2e-07
Identities = 167/802 (20%), Positives = 304/802 (37%), Gaps = 72/802 (8%)
Query: 757 KESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGA--VHEAPLRAWK- 813
++ ++L + EK+E +E+ + Q RD ++ + + E W E E L++ K
Sbjct: 143 EQERELAEGEEQSEKQERLEQRDR-QRRDEELWRQRQE---WQEREERRAEEEQLQSCKG 198
Query: 814 -PTAEQPELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGG--SDPIGQAAAKDAVGL 870
T E P+ EE +RE+ +E +G E + RR + + + K L
Sbjct: 199 HETEEFPD--EEQLRRREL---LELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVL 253
Query: 871 SKDEA------PEKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALRE 924
K+E P++Q + E + E E+ + L E E
Sbjct: 254 RKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEE 313
Query: 925 AATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKER 984
+E E E E+ ++ + ++E+ E L E+ + R
Sbjct: 314 RREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERR 373
Query: 985 KEVMRTETRLSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDV--EGEEMVTEAEANR 1042
++ +R E +L +++ + E L +E L +E +++ E E R
Sbjct: 374 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEER 433
Query: 1043 EDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEVTRANAL--KDEDAFKEEQKLKA 1100
+ + E +E L RE+ ER R+ ++ER E R +D++ + E+ LK
Sbjct: 434 HEQKHEQERREQRLKREQE--ERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKL 491
Query: 1101 EEGET-ETEVRAEEETKAPPNEMGSDA----ENEAPVEASELSDNPGLLGEDSLKETVVP 1155
EE E E + R E++ + E E E ++ S+ ++ +E ++
Sbjct: 492 EEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLK 551
Query: 1156 IFEATPGFEKSLENITALRKEGGGERLSEARDTEHKDREELSSRENRALKEGHRQDGEGA 1215
E EK LE R+E +R E R + REE R + LK + E
Sbjct: 552 REE-----EKRLEQE---RREQRLKREQEERRDQLLKREE--ERRQQRLKREQEERLEQR 601
Query: 1216 LAAPEAEPAGKVQAPEGLIPATGQAEE-----LAAKDHDSCAGLEGRAEGQGGVDVVLRT 1270
L E E + + E + EE L +++ + + R E Q + L+
Sbjct: 602 LKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKR 661
Query: 1271 QEAVAEEDPIMAEKFREEAVDEDPEEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNE 1330
+E + + + EE +++ EEE ++ E ++ R + +E E + ++++
Sbjct: 662 EEEEERLEQRLKREHEEERREQELAEEEQEQAR---ERIKSRIPKWQWQLESEADARQSK 718
Query: 1331 GMGGGRVVAVEVLHGGGETAETAAEEREVLAGSETA-EEKTIANKASSFSDVAEEETWHQ 1389
R G+ EE+ SE +E+ A++ + + TW
Sbjct: 719 VYSRPRKQE-------GQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQW 771
Query: 1390 QDELVGKTA----AAGKVVVEELARS--GEEVPAAEEMTVTYTTEAGVGTPGALERKTSG 1443
Q E + +A + E+ R EE E+ + E ER+
Sbjct: 772 QAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKEL 831
Query: 1444 LGQEQEEGSEGQEAATGSGDGRQETGAAEKFRLGLSREGERE------LSPESLQAMATL 1497
E+EE + +E A + +E G E S+E R+ L E + TL
Sbjct: 832 QFLEEEEQLQRRERAQQLQE--EEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTL 889
Query: 1498 PVKPDFTETREKQQHMVQGESE 1519
KP E K+Q ++Q E E
Sbjct: 890 YAKPALQEQLRKEQQLLQEEEE 911
Score = 56.2 bits (134), Expect = 2e-07
Identities = 166/846 (19%), Positives = 318/846 (37%), Gaps = 102/846 (12%)
Query: 414 KEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVTAVE 473
+E+ ++ E+L + E + R+ +E R E + + QE + +E E
Sbjct: 1143 EEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREE 1202
Query: 474 EMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPLDD 533
E + K Q ++DQ + LK+++E E + + K +G+ + Q + S L D
Sbjct: 1203 EELQRQKRKQRYRDEDQRSDLKWQWEP--EKENAVRDNKVYCKGRENEQFRQLEDSQLRD 1260
Query: 534 KKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSSRSHPYSSD 593
++ D + ++ + + D E + ++++ K A +S
Sbjct: 1261 RQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQL 1320
Query: 594 SEDESAVGDREAHTDSSTDESAR---RSSSQELSENDKPRKSHLPIEESLEIEIEDQEIT 650
+E R TD E + Q L ++ RK EE L + + ++
Sbjct: 1321 LREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFR---EEELRHQEQGRKFL 1377
Query: 651 KADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKE---KDKSKLWEE 707
+ + + + F LKE + QE + L + + EE++ +++ + + E
Sbjct: 1378 EEEQRLRRQERERKF---LKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFRE 1434
Query: 708 STAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQKTY 767
QV+ ++ LEE + L +E +QL+Q
Sbjct: 1435 EEQQVRRQERERKFLEE--EQQL------------------RQERHRKFREEEQLLQ--- 1471
Query: 768 TLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEFTE 827
E E+ Q RD ++ + + E LR+ +P E+ L EE
Sbjct: 1472 -----EREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEP--ERKFLEEEQQL 1524
Query: 828 KREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAP---EKQALMLT 884
R+ +R + E + +RR G Q +D ++E E++ L+
Sbjct: 1525 HRQ-----QRQRKFLQEEQQLRRQERG------QQRRQDRDRKFREEEQLRQEREEQQLS 1573
Query: 885 VLETDKAASEGEQGL-----EKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAV 939
E D+ EQ + E+ + +E E ++ R+ E+ +
Sbjct: 1574 RQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQL------ 1627
Query: 940 SDVGESEEEASIDLE-DTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFT 998
+ E EE+ E D +E+ R E+ + +R R E +L
Sbjct: 1628 --LQEREEQQLHRQERDRKFLEEEPQLRRQEREQQL------RHDRDRKFREEEQLLQEG 1679
Query: 999 GEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLAR 1058
E + R + EE + ++ ++ E+ + E R+ +E L +E + +
Sbjct: 1680 EEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQ 1739
Query: 1059 ERRKAERPKTSLRKTD--SEREEVTRANALKDEDAFKEEQKLKAE-------EGETETEV 1109
RR+ ER + L + EREE +D F+EE++L+ E E++ +
Sbjct: 1740 LRRQ-ERYRKILEEEQLRPEREEQQLRRQERDRK-FREEEQLRQEREEQQLRSQESDRKF 1797
Query: 1110 RAEEETKAPPNE-----MGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFE 1164
R EE+ + E D + E +L + L ++ ++ AT E
Sbjct: 1798 REEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQ--E 1855
Query: 1165 KSLENITALRKEGGGERLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPA 1224
KS L +E E ++ E K REE R+ + ++ HRQ GE + + E +
Sbjct: 1856 KSRREEQELWQE---EEQKRRQERERKLREEHIRRQQKE-EQRHRQVGE--IKSQEGKGH 1909
Query: 1225 GKVQAP 1230
G++ P
Sbjct: 1910 GRLLEP 1915
Score = 50.1 bits (118), Expect = 2e-05
Identities = 153/765 (20%), Positives = 264/765 (34%), Gaps = 116/765 (15%)
Query: 567 ESELEEDKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSEN 626
E + + +D + R + E E A G+ ++ ++ R+ +EL
Sbjct: 117 EDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWR- 175
Query: 627 DKPRKSHLPIEESLEIEIEDQEITKADVETKPMPIDESFEN-VLKEGTEKGTQEIAEGLS 685
++ E E E + K ET+ P +E L E KG +E +
Sbjct: 176 ---QRQEWQEREERRAEEEQLQSCKGH-ETEEFPDEEQLRRRELLELRRKGREEKQQQRR 231
Query: 686 EKSGKHVSAEEKE----------KDKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYV 735
E+ + EE++ K++ KL EE + ++ + L + + L
Sbjct: 232 ERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQEL----- 286
Query: 736 LALGAPTMNFMVDETAAINSNKESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEA 795
++ QQ +++ L +K+ EE+ Q + Q + E
Sbjct: 287 --------------RRERQEEEQQQQRLRREQQLRRKQ--EEERREQQEERREQQERRE- 329
Query: 796 ALWGEAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGG 855
+ E LR + + +L E E+R + R E + +RR
Sbjct: 330 ----QQEERREQQLRREQEERREQQLRREQEEERR-EQQLRREQEEERREQQLRREQ--- 381
Query: 856 SDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEH 915
Q + + + E+Q L ++ +Q + L E E
Sbjct: 382 -----QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQ 436
Query: 916 LHEVAALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKREDGSEEAIL 975
HE + E+ E D + EEE ++ + + E+ E +
Sbjct: 437 KHEQERREQRLKREQEERR------DWLKREEETERHEQERRKQQLKRDQEEERRERWLK 490
Query: 976 GGEEPAKERKEVMRTETRLSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMV 1035
EE +E++E + R E E R Q + EE L + L E +++
Sbjct: 491 LEEEERREQQERREQQLRR-----EQEERREQRLKRQEEEERLQQR--LRSE----QQLR 539
Query: 1036 TEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEE 1095
E E RE K K L+ R ++ +R + R +REE R LK E + E
Sbjct: 540 REQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLE 599
Query: 1096 QKLKAEEGE-TETEVRAEEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVV 1154
Q+LK EE E E E R E+ K E P E + LK
Sbjct: 600 QRLKREEVERLEQEERREQRLK-----------REEPEEERR---------QQLLKSE-- 637
Query: 1155 PIFEATPGFEKSLENITALRKEGGGERLSEARDTEHKDREELSSRENRALKEGHRQDGEG 1214
E+ LR+E E R+ K EE E R +E + E
Sbjct: 638 ---------EQEERRQQQLRRE-----QQERREQRLKREEEEERLEQRLKREHEEERREQ 683
Query: 1215 ALAAPEAEPAG---KVQAPEGLIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQ 1271
LA E E A K + P+ +A+ +K + EG+ Q +
Sbjct: 684 ELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQ-------EQE 736
Query: 1272 EAVAEEDPIMAEKFREEAVDEDPEEEEDKECTLETEAMQDRNSEG 1316
E + + + E A + EEE+ ++ T + +A ++++ G
Sbjct: 737 EKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQA-EEKSERG 780
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 69.3 bits (168), Expect = 3e-11
Identities = 223/1076 (20%), Positives = 406/1076 (37%), Gaps = 163/1076 (15%)
Query: 523 MNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASS 582
++G P SP+ D P+ + ++ D R N +DE E EL E+++ +
Sbjct: 197 LSGSPASPMGDILQT--PQFQMRRLKKQLADERSN-RDE----LELELAENRKLL----- 244
Query: 583 TSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSS----QELSE-NDKPRKSHLPIE 637
+E ++ + + D + ++++S +EL E DK + +
Sbjct: 245 -----------TEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMRLH 293
Query: 638 ESLEIEIEDQEITKADVETKPMPIDESFENVLKEGTEKGT--QEIAEGLSEKSGKHVSAE 695
E+L+ + +D + K+ ++ K + E ++ + E + Q++ + L+E + +H A
Sbjct: 294 ETLK-QCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKAT 352
Query: 696 EKEKDK-SKLWEESTAQVKDKKA----------GLPGLEEGG---KDSLPLAYVLALGAP 741
++ +K ++L +E +A ++DKK L LEE +D+ P LG
Sbjct: 353 QEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLG-- 410
Query: 742 TMNFMVDETAAINSNKESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEA 801
D +E+ L L+ + M E E +G+ EA L E
Sbjct: 411 ------DVLQLETLKQEAATLAANNTQLQARVEMLETE----------RGQQEAKLLAER 454
Query: 802 GAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAEG---AAEAEGVRRLGEGGS-- 856
G E E+ +L+ T+ + + + E A++A G R + S
Sbjct: 455 GHFEE----------EKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLT 504
Query: 857 ------DPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANEAAA 910
+ Q ++ GL K +A EKQA + L+ + AS+G L ++
Sbjct: 505 SELTTLNATIQQQDQELAGL-KQQAKEKQAQLAQTLQQQEQASQG--------LRHQVEQ 555
Query: 911 LNLEHLHEVAALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKREDGS 970
L+ + L+E A +E + E EAS+ D + A ++E +
Sbjct: 556 LSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAA 615
Query: 971 EEAILGGEEPAKERKEVMRTETRLSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVE 1030
+ IL +++ + E R S T +A R + E A +E E
Sbjct: 616 KLEIL-------QQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHE 668
Query: 1031 GEEMVTEAEANREDDR-----KEILPKELDLARERRKAERPKTSLRKTDSEREEVTRANA 1085
+ V E E ++ KE + +E D +E+ +A + + K E E+ A+A
Sbjct: 669 AQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADA 728
Query: 1086 LKDEDAFKEEQKL---------KAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEASE 1136
L+++ E K K E E E E + +A ++G + E V E
Sbjct: 729 LEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRE 788
Query: 1137 LSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGG---ERLSEARDTEHKDR 1193
L++ + + + + + + + + E+ + G E+L ++ K R
Sbjct: 789 LAE--AMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKAR 846
Query: 1194 EEL-SSRENRALKEGH------RQDGEGA-LAAPEAEPAGKVQAPEGLIPATGQAEELAA 1245
+EL ++E A E H RQ E A L A A +VQ E + A A++L+
Sbjct: 847 QELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKE--VRAQKLADDLST 904
Query: 1246 KDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDP---EEEEDKEC 1302
A + A + V QE + E ++ E R A D P EE++ ++
Sbjct: 905 LQEKMAATSKEVARLETLVRKAGEQQETASRE--LVKEPAR--AGDRQPEWLEEQQGRQF 960
Query: 1303 TLETEAMQ--DRNSEGDGD---------MEGEGNTQKNEGMGGGRVVAVEVLHGGGETAE 1351
A+Q +R +E G+ ME +G Q+ G V + G
Sbjct: 961 CSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREV--ARLTQERGRAQA 1018
Query: 1352 TAAEEREVLAGSETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKV------VV 1405
A E+ A E + + + F+ + +E H E GK K+ +
Sbjct: 1019 DLALEKAARAELEMRLQNALNEQRVEFATL-QEALAHALTEKEGKDQELAKLRGLEAAQI 1077
Query: 1406 EELARSGEEVPAAEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEGSEGQEAATGSGDGR 1465
+EL + V +E E G+ + + +G + E A + +
Sbjct: 1078 KELEELRQTVKQLKEQLAKKEKEHASGS--GAQSEAAGRTEPTGPKLEALRAEVSKLEQQ 1135
Query: 1466 QETGAAEKFRLGLSREGERELSPESLQAMATLPVKPDFTETREKQQHMVQGESETA 1521
+ + L S E ER E A+ TL + EK Q + +S A
Sbjct: 1136 CQKQQEQADSLERSLEAERASRAERDSALETLQ-----GQLEEKAQELGHSQSALA 1186
Score = 39.3 bits (90), Expect = 0.030
Identities = 143/710 (20%), Positives = 271/710 (38%), Gaps = 72/710 (10%)
Query: 497 EYEEDFEVDEEKQGEKSNEEG--QADVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDA 554
+ +E+ E + + E G QAD+ + ++ L+ + N E+ E ++ + A
Sbjct: 994 QQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALA 1053
Query: 555 RDNVKDEN-----------DGCSESELEEDKQDMKTASST-SSRSHPYSSDSEDESAVGD 602
+ E + ELEE +Q +K + + ++S S +S
Sbjct: 1054 HALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAG 1113
Query: 603 REAHTDSSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIEDQEITKADVETKPMPID 662
R T E+ R S+ + K ++ +E SLE E + + +ET ++
Sbjct: 1114 RTEPTGPKL-EALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLE 1172
Query: 663 ESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSKLWEESTAQVKDKKAGLPGL 722
E + E G + A L+ + + K +D SK +E AQV +
Sbjct: 1173 EKAQ-------ELGHSQSA--LASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQ----- 1218
Query: 723 EEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQKTYTLEKKEAMEEDEAPQ 782
E K+SL + L +N V E +KE ++LV E +++ + +E +
Sbjct: 1219 EAERKNSLISS--LEEEVSILNRQVLEKEG--ESKELKRLVMA----ESEKSQKLEERLR 1270
Query: 783 HRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAEGA 842
A+ AA E + +++ + AE+ +A E ++E+ ER E
Sbjct: 1271 LLQAETASNSARAA---ERSSALREEVQSLREEAEKQRVASE-NLRQELTSQAERAEELG 1326
Query: 843 AEAEGVRRLGEGGSDPIG--QAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLE 900
E + + + Q L + P K + L+ ++AA+E E
Sbjct: 1327 QELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKH--LCQQLQAEQAAAEKRHREE 1384
Query: 901 KAVLANEAAALNLE------HLHEVAALREAATSEEGEAEGGVAVSDVGESEEEASIDLE 954
A L E L E+ LR+ +E A+ A + E+ S+ +
Sbjct: 1385 LEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRA--EKASYAEQLSMLKK 1442
Query: 955 DTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETR-LSPFTGEAEASRMQVSEGSP 1013
G + A + E A LG + E + + L+ +AE +++E
Sbjct: 1443 AHGLL---AEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAET---RLAEVQR 1496
Query: 1014 EEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKT 1073
E S A+E + EG ++ E R + ++ L ++ E+ + R+
Sbjct: 1497 EAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQV---------EQLEVFQREQ 1547
Query: 1074 DSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPNEMGSD-AENEAPV 1132
+ EE+++ A D+ + ++QKLKA + + + + +A NE+ + ++ E
Sbjct: 1548 TKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAA 1607
Query: 1133 EASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGERL 1182
E +L D+ K+ + E E+ + LR E ERL
Sbjct: 1608 EHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAE--AERL 1655
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 69.3 bits (168), Expect = 3e-11
Identities = 180/957 (18%), Positives = 383/957 (40%), Gaps = 80/957 (8%)
Query: 403 LDKKPSLPKSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIK 462
L+ K R E+ E EL + K+ E + ++++ V + A E K
Sbjct: 918 LEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENK 977
Query: 463 T-GLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADV 521
L E + ++E +K ++ L++ + TL +D + +E+K + + + +
Sbjct: 978 VKNLTEEMAGLDETIAKLSKEKKALQETHQQTL-----DDLQAEEDKVNILTKAKTKLEQ 1032
Query: 522 QMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTAS 581
Q++ + S +KK +D E+ A+++ D + + + + +K++ + ++
Sbjct: 1033 QVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISN 1092
Query: 582 STSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEESLE 641
S + + + + + + +A + +E +S+ +E + S +EE E
Sbjct: 1093 LISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSR-ELEEISE 1151
Query: 642 IEIEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDK 701
E T A VE E+ L+ E+ T + ++ KH + + ++
Sbjct: 1152 RLEEAGGATSAQVELNKK--REAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQ 1209
Query: 702 SKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALG--APTMNFMVDETAAINSNKES 759
+ +++ +K+ L +E S A A G + D+ + + + +E
Sbjct: 1210 IDNLQRVKQKLEKEKSELK-METDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEE 1268
Query: 760 QQLVQKTYTLEKKEAMEE--DEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAE 817
QQ + T ++ E + + Q + D + + + + E + + T
Sbjct: 1269 QQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKA 1328
Query: 818 QPELAEEFTEKRE----IPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAK---DAVGL 870
+ LA R + E EG AE + R L + S+ + Q K DA+
Sbjct: 1329 KNALAHALQSSRHDCDLLREQYEEEQEGKAELQ--RALSKANSE-VAQWRTKYETDAIQR 1385
Query: 871 SK--DEAPEKQALMLTVLETDKAASEGE-QGLEKAV--LANEAAALNLEHLHEVAALREA 925
++ +EA +K A L E A + LEK L NE L L+ AA
Sbjct: 1386 TEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAA---C 1442
Query: 926 ATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKREDGSEEA----ILGGEEPA 981
A ++ + +S+ + EE +LE AS++E S + E +
Sbjct: 1443 AALDKKQRNFDKVLSEWKQKYEETQAELE--------ASQKESRSLSTELFKVKNVYEES 1494
Query: 982 KERKEVMRTETRLSPFTGEAEASRMQVSEGSPEEGSLAK-EAFLCKEDVEGEEMVTEAEA 1040
++ E +R E + E Q++EG + L K + + +E E + + EAEA
Sbjct: 1495 LDQLETLRRENK--NLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEA 1552
Query: 1041 NREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEVTR--------------ANAL 1086
+ E + +IL +L+L + + + +R + + D E +++ R A
Sbjct: 1553 SLEHEEGKILRIQLELNQVKSEVDR---KIAEKDEEIDQLKRNHTRVVETMQSTLDAEIR 1609
Query: 1087 KDEDAFKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEAPVEASELSDNPGLLGE 1146
DA + ++K++ + E E++ + + + + ++ ++L + L G+
Sbjct: 1610 SRNDALRVKKKMEGD--LNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQ 1667
Query: 1147 DSLKETVVPIFEATPGFEKSLENITA-LRKEGGGERLSEARDTEHKDREELSSRENRALK 1205
+ LKE + + + +E + A L + +++E + +R +L +N +L
Sbjct: 1668 EDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLI 1727
Query: 1206 EGHRQ-DGEGALAAPEAEPA------GKVQAPEGLIPATGQAEELAAKDHDSCAGLEGRA 1258
++ + + + E E + +A + + A AEEL K+ D+ A LE
Sbjct: 1728 NTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEEL-KKEQDTSAHLERMK 1786
Query: 1259 EGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEEEDKECTLETEAMQDRNSE 1315
+ ++ ++ + +E +A K ++ + + E +E E E Q RN+E
Sbjct: 1787 K---NLEQTVKDLQHRLDEAEQLALKGGKKQIQK--LEARVRELEGEVENEQKRNAE 1838
Score = 52.8 bits (125), Expect = 3e-06
Identities = 156/775 (20%), Positives = 298/775 (38%), Gaps = 96/775 (12%)
Query: 399 IAMGLDKKPSLPKSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSA 458
+ + L KK ++R E+ E+ E + + K K+R + + EI E SA
Sbjct: 1103 VEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSA 1162
Query: 459 QEIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQ 518
Q VE + Q++ D +E TL ++E +K + E G+
Sbjct: 1163 Q------------VELNKKREAEFQKLRRDLEEATL--QHEAMVAALRKKHADSMAELGE 1208
Query: 519 ADVQMNGIPQSPLDDKKDNLDPEKESETSSQKA-PDARDNV----KDENDGCSESELEED 573
+ + Q L+ +K L E + +S+ +A A+ N+ + D SE + +E+
Sbjct: 1209 QIDNLQRVKQK-LEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEE 1267
Query: 574 KQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSE----NDKP 629
+Q T+ R+ + E + +++A S ++++S+Q++ E ++
Sbjct: 1268 EQQRLINDLTAQRARLQTEAGEYSRQLDEKDALV--SQLSRSKQASTQQIEELKHQLEEE 1325
Query: 630 RKSHLPIEESLEIEIEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSG 689
K+ + +L+ D ++ + E ++ + L+ K E+A+ ++
Sbjct: 1326 TKAKNALAHALQSSRHDCDLLREQYEE-----EQEGKAELQRALSKANSEVAQWRTKYET 1380
Query: 690 KHVS-AEEKEKDKSKL---WEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNF 745
+ EE E+ K KL +E+ V+ A LE+ + L L N
Sbjct: 1381 DAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSN- 1439
Query: 746 MVDETAAINSNKESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVH 805
AA++ + + V + + +E E EA Q + L+
Sbjct: 1440 --AACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSL-----STELFKVKNVYE 1492
Query: 806 EAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAK 865
E+ + E L +E ++ E I G + E E +++ E I QAA +
Sbjct: 1493 ESLDQLETLRRENKNLQQEISDLTE---QIAEGGKQIHELEKIKKQVEQEKCEI-QAALE 1548
Query: 866 DAVGLSKDEAPEKQALMLTV----LETDKAASEGEQGLEK------AVLANEAAALNLEH 915
+A + E + + L + E D+ +E ++ +++ V+ + L+ E
Sbjct: 1549 EAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEI 1608
Query: 916 LHEVAALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDT-GPMEDTASKREDGSEEAI 974
ALR E E + ++ E+ + +T G +++T +D
Sbjct: 1609 RSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDA----- 1663
Query: 975 LGGEEPAKERKEVMRTETRLSPFTGE---------------AEASRMQVSEG----SPEE 1015
L G+E KE+ ++ L E AE + SE +
Sbjct: 1664 LRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQN 1723
Query: 1016 GSLAKEAFLCKEDV-----EGEEMVTEAEANREDDRKEILPKELDLARERRK-------A 1063
SL + DV E EE++ E+ N E+ K+ + +A E +K
Sbjct: 1724 TSLINTKKKLENDVSQLQSEVEEVIQESR-NAEEKAKKAITDAAMMAEELKKEQDTSAHL 1782
Query: 1064 ERPKTSLRKTDSE-REEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKA 1117
ER K +L +T + + + A L + K+ QKL+A E E EV E++ A
Sbjct: 1783 ERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNA 1837
>gi|7657138 golgi integral membrane protein 4 [Homo sapiens]
Length = 696
Score = 68.9 bits (167), Expect = 3e-11
Identities = 145/717 (20%), Positives = 264/717 (36%), Gaps = 115/717 (16%)
Query: 411 KSRKEKSTEKGEELKKAEGKVRKER--EYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEV 468
+SR EKS +K ++ E K KE Y + + + + + ++++SA +
Sbjct: 68 RSRLEKSLQK----ERLEHKKAKEDFLVYKLEAQETLNKGRQDSNSRYSALNV------- 116
Query: 469 VTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQ 528
Q + Q LK ++ D E + KQGE +
Sbjct: 117 --------------QHQMLKSQHEELKKQHS-DLEEEHRKQGEDFSRTFN---------- 151
Query: 529 SPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSSRSH 588
D K+ L ++E E K + N+++EN +L + QD+ T + H
Sbjct: 152 ---DHKQKYLQLQQEKEQELSKLKETVYNLREEN-----RQLRKAHQDIHTQLQDVKQQH 203
Query: 589 PYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIEDQE 648
+ SE E V E H +SA ++ +++E K K L SL
Sbjct: 204 K-NLLSEHEQLVVTLEDH------KSALAAAQTQVAEY-KQLKDTLNRIPSLR------- 248
Query: 649 ITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSKLWEES 708
KP P ++ +NV + A EK + V + D + E
Sbjct: 249 --------KPDPAEQ--QNVTQVAHSPQGYNTAR---EKPTREVQEVSRNNDVWQNHEAV 295
Query: 709 TAQVKDKKAGLPGLEEGGKDSLP--LAYVLALGAPTMNFMVDETAAINSNKESQQLVQKT 766
+ +D K P +E + P + + P + + +E +E +Q+ Q
Sbjct: 296 PGRAEDTKLYAPTHKEAEFQAPPEPIQQEVERREPEEHQVEEEHRKALEEEEMEQVGQAE 355
Query: 767 YTLEKKEAMEEDEAPQHRD-------ADIVQGKGEAALWGEAGAV------HEAPLRAWK 813
+ E+ + E++ + ++ A++++G A ++ A + +E L +
Sbjct: 356 HLEEEHDPSPEEQDREWKEQHEQREAANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQR 415
Query: 814 PTAEQPELAEEFTEKREIPPGIERGAEGAAEAEG-VRRLGEGGSDPIGQAAAKDAVGLSK 872
+Q E A++ E +E A +G + R E + + A +
Sbjct: 416 LAVQQVEEAQQLREHQE--------ALHQQRLQGHLLRQQEQQQQQVAREMALQRQAELE 467
Query: 873 DEAPEKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGE 932
+ P+ Q + D ++ QG E + E A ++ H+ A + E
Sbjct: 468 EGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGAYERDNQHQDEAEGDPGNRHEPR 527
Query: 933 AEGGVAVSDVGESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTET 992
+G E++ A +ED P +D ++ ED EEA EE + E +
Sbjct: 528 EQGPREADPESEADRAA---VEDINPADDPNNQGEDEFEEAEQVREENLPDENEEQKQSN 584
Query: 993 RLSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPK 1052
+ T E V G+P++ +ED E+ EAE ++D E +
Sbjct: 585 QKQENT---EVEEHLVMAGNPDQ----------QEDNVDEQYQEEAEEEVQEDLTEEKKR 631
Query: 1053 ELDLARERRKAERPK-TSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETE 1108
EL+ E E + T + D E +EV N K + EE++ + E+G E
Sbjct: 632 ELEHNAEETYGENDENTDDKNNDGEEQEVRDDNRPKGREEHYEEEEEEEEDGAAVAE 688
Score = 43.1 bits (100), Expect = 0.002
Identities = 102/503 (20%), Positives = 180/503 (35%), Gaps = 95/503 (18%)
Query: 1003 ASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRK 1062
A++ QV+E + +L + L K D ++ VT+ + P+ + ARE
Sbjct: 226 AAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAHS---------PQGYNTARE--- 273
Query: 1063 AERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKL--KAEEGETETEVRAEEETKAPPN 1120
K E +EV+R N D ++ + + +AE+ + E E +APP
Sbjct: 274 ---------KPTREVQEVSRNN-----DVWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPE 319
Query: 1121 EMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEGGGE 1180
+ + E P E ++ L E+ +++ G E
Sbjct: 320 PIQQEVERREPEEHQVEEEHRKALEEEEMEQV------------------------GQAE 355
Query: 1181 RLSEARD--TEHKDR---EELSSRENRALKEGHRQDGEGALAAPEAEPAGKVQAP----- 1230
L E D E +DR E+ RE L EGH + A P A+P K Q+P
Sbjct: 356 HLEEEHDPSPEEQDREWKEQHEQREAANLLEGHAR----AEVYPSAKPMIKFQSPYEEQL 411
Query: 1231 EGLIPATGQAEELAAKDHDSCAGLEGRAEG-----------QGGVDVVLRTQEAVAEEDP 1279
E A Q EE A + R +G Q ++ L+ Q + E P
Sbjct: 412 EQQRLAVQQVEEAQQLREHQEALHQQRLQGHLLRQQEQQQQQVAREMALQRQAELEEGRP 471
Query: 1280 IMAEKFRE----EAVDEDPEEEEDKECTLETEAMQDRNSEGDGDMEGE-GNTQKNEGMGG 1334
E+ R+ +A+D D + + + E +R+++ + EG+ GN + G
Sbjct: 472 QHQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGAYERDNQHQDEAEGDPGNRHEPREQGP 531
Query: 1335 GRV--------VAVEVLHGGGETAETAAEEREVLAGSETAEEKTI--ANKASSFSDVAEE 1384
AVE ++ + +E E +E E+ + N+ S+ +E
Sbjct: 532 READPESEADRAAVEDINPADDPNNQGEDEFE---EAEQVREENLPDENEEQKQSNQKQE 588
Query: 1385 ETWHQQDELVGKTAAAGKVVVEELARSGEEVPAAEEMTVTYTTEAGVGTPGALERKTSGL 1444
T ++ ++ + V+E + E E++T E
Sbjct: 589 NTEVEEHLVMAGNPDQQEDNVDEQYQEEAEEEVQEDLTEEKKRELEHNAEETYGENDENT 648
Query: 1445 GQEQEEGSEGQEAATGSGDGRQE 1467
+ +G E + GR+E
Sbjct: 649 DDKNNDGEEQEVRDDNRPKGREE 671
Score = 38.5 bits (88), Expect = 0.050
Identities = 78/379 (20%), Positives = 144/379 (37%), Gaps = 41/379 (10%)
Query: 947 EEASIDLEDTGPMEDTASKR----EDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAE 1002
EE ++ E +E+ ++ E EE EE +E KE + G A
Sbjct: 331 EEHQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQREAANLLEGHAR 390
Query: 1003 A-----SRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLA 1057
A ++ + SP E L ++ ++ E +++ EA + + L ++ +
Sbjct: 391 AEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLREHQEALHQQRLQGHLLRQQEQQ 450
Query: 1058 RE---RRKAERPKTSLRKTDSEREEVTRANA---LKDEDAFK--EEQKLKAEEGETETEV 1109
++ R A + + L + + +E R A D D + E+Q ++ EEG E +
Sbjct: 451 QQQVAREMALQRQAELEEGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGAYERDN 510
Query: 1110 RAEEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLEN 1169
+ ++E + P E + P EA S+ + + E + P + E E
Sbjct: 511 QHQDEAEGDPGNRHEPRE-QGPREADPESE-----ADRAAVEDINPADDPNNQGEDEFEE 564
Query: 1170 ITALRKEGGGERLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKVQA 1229
+R+E + E + + K +E + E + G+ E + E A + +
Sbjct: 565 AEQVREENLPDENEEQKQSNQK--QENTEVEEHLVMAGNPDQQEDNVDEQYQEEAEE-EV 621
Query: 1230 PEGLIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAE---KFR 1286
E L E+ +H++ E G D + EE + + K R
Sbjct: 622 QEDLTE-----EKKRELEHNA-------EETYGENDENTDDKNNDGEEQEVRDDNRPKGR 669
Query: 1287 EEAVDEDPEEEEDKECTLE 1305
EE +E+ EEEED E
Sbjct: 670 EEHYEEEEEEEEDGAAVAE 688
Score = 36.6 bits (83), Expect = 0.19
Identities = 29/144 (20%), Positives = 62/144 (43%), Gaps = 12/144 (8%)
Query: 488 DDQENTLKYEYEEDFEVDEEKQGEKSNEEGQA-------DVQMNGIPQSPLDDKKDNLDP 540
DD N + E+EE +V EE +++ E+ Q+ +V+ + + D ++DN+D
Sbjct: 552 DDPNNQGEDEFEEAEQVREENLPDENEEQKQSNQKQENTEVEEHLVMAGNPDQQEDNVDE 611
Query: 541 EKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSSRSHPYSSDSEDESAV 600
+ + E + D + K E + +E E+ ++ ++ + D++
Sbjct: 612 QYQEEAEEEVQEDLTEEKKRELEHNAEETYGENDENTDDKNNDGE-----EQEVRDDNRP 666
Query: 601 GDREAHTDSSTDESARRSSSQELS 624
RE H + +E ++ E S
Sbjct: 667 KGREEHYEEEEEEEEDGAAVAEKS 690
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 68.2 bits (165), Expect = 6e-11
Identities = 153/783 (19%), Positives = 299/783 (38%), Gaps = 97/783 (12%)
Query: 415 EKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVTAVEE 474
E+ TE+ E+ K+A+ + K ++ + K N + V + + QE++ K++ V+E
Sbjct: 1206 EELTEQLEQFKRAKANLDKNKQ-TLEKENADLAGELRVLGQ-AKQEVEHKKKKLEAQVQE 1263
Query: 475 MTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQ--SPLD 532
+ SK G+ + + K + E E G + EG+A + S L
Sbjct: 1264 LQSKCSDGERARAELNDKVHKLQNEV-----ESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1318
Query: 533 DKKDNLDPEKESE----TSSQKAPDARDNVKDENDGCSES-------------ELEEDKQ 575
D ++ L E + T ++ + R++++D+ D E+ +L + K+
Sbjct: 1319 DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK 1378
Query: 576 DMKTASST-----------SSRSHPYSSDSEDESAVGDREAHT---------DSSTDESA 615
++ +ST + E+++A D+ T D D
Sbjct: 1379 KLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN 1438
Query: 616 RRSSSQELSENDKPRKSHLPIEESLEIEIEDQ----EITKADVETKPMPIDESFENVL-- 669
+R L + + L E+++ + D+ E + ETK + + + E L
Sbjct: 1439 QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEA 1498
Query: 670 KEGTEKGTQ----EIAEGLSEKSGKHVSAEEKEKDKSKLWEESTAQVKDKKAGLPGLEEG 725
KE E+ + E+ + +S K + E EK K L Q+++ K L LE+
Sbjct: 1499 KEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRAL----ETQMEEMKTQLEELEDE 1554
Query: 726 --GKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQKTYTLEKKEAMEEDEAPQH 783
+ L + + A F D A N+E ++ +Q+ L + E EDE Q
Sbjct: 1555 LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQ--LHEYETELEDERKQR 1612
Query: 784 RDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAEGAA 843
A + K E G + + L+A + E ++ + + +R E A
Sbjct: 1613 ALAAAAKKKLE-------GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDAR 1665
Query: 844 EAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLE-KA 902
+ ++ ++ D + L +D A ++A LE ++ A E L +
Sbjct: 1666 ASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRN 1725
Query: 903 VLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSD-VGESEEEASIDLEDTGPMED 961
L +E L +A L E E+G E A+SD V ++ ++A +
Sbjct: 1726 ALQDEKRRLEAR----IAQLEEELEEEQGNME---AMSDRVRKATQQAEQLSNELATERS 1778
Query: 962 TASKREDGSEEAI------------LGGEEPAKERKEVMRTETRLSPFTGEAEAS---RM 1006
TA K E ++ + G +K + + E +++ + E +
Sbjct: 1779 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1838
Query: 1007 QVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERP 1066
++ ++ KE L ED + +A + + R + L ++L+ A E +++R
Sbjct: 1839 AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEE--ESQRI 1896
Query: 1067 KTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDA 1126
+ RK E +E T +N + + KL+ + R + N GS+
Sbjct: 1897 NANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADGSEE 1956
Query: 1127 ENE 1129
E +
Sbjct: 1957 ETD 1959
Score = 61.6 bits (148), Expect = 6e-09
Identities = 211/1152 (18%), Positives = 418/1152 (36%), Gaps = 142/1152 (12%)
Query: 406 KPSLPKSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSA----KFSAQEI 461
KP L +R+E EE++ E +++K +E NE+KE + S K QE
Sbjct: 842 KPLLQVTRQE------EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 895
Query: 462 KTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADV 521
E+ EEM + ++ LE+ + +E E E +E++ + E +
Sbjct: 896 LQAETELYAEAEEMRVRLAAKKQELEE-----ILHEMEARLEEEEDRGQQLQAERKKMAQ 950
Query: 522 QMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNV---KDENDGCSESE--LEEDKQD 576
QM + + +++ + E T+ K D + D+N+ S+ LEE D
Sbjct: 951 QMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISD 1010
Query: 577 MKT--ASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHL 634
+ T A + ++ ES + + E + E D
Sbjct: 1011 LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 1070
Query: 635 PIEESLEIEIEDQEITKADVETKPM--PIDESF---ENVLKE--GTEKGTQEIAEGLSEK 687
+ +I ++ K + E + +D+ N LK+ E ++ E L +
Sbjct: 1071 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1130
Query: 688 SGKHVSAEEKEKDKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMV 747
AE++++D + E +++D +E VL
Sbjct: 1131 RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1190
Query: 748 DETAAINSNKESQQLVQKTYTLE--KKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVH 805
+ K +Q + + T LE K+ D+ Q + + GE + G+A
Sbjct: 1191 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAK--Q 1248
Query: 806 EAPLRAWKPTAEQPELAEEFTE----KREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQ 861
E + K A+ EL + ++ + E+ + + G+ EG + + +
Sbjct: 1249 EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAK 1308
Query: 862 AAA------KDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANE-----AAA 910
A +D L ++E +K + + + ++ + + L++ + A + +
Sbjct: 1309 DVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIST 1368
Query: 911 LNLEHLHEVAALREAATS----EEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKR 966
LN++ L++ A++ EEG+ + ++ + EE + + +E T ++
Sbjct: 1369 LNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDK---LEKTKNRL 1425
Query: 967 E----------DGSEEAILGGEEPAKERKEVMRTETRLSP-FTGEAEASRMQVSEGSPEE 1015
+ D + + E+ ++ +++ E +S + E + + + E +
Sbjct: 1426 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA 1485
Query: 1016 GSLAK---EAFLCKEDVEGEEMVTEAE-----ANREDDRKEILPKELDLARERRKAERPK 1067
SLA+ EA KE++E + +AE ++++D K + E + E K
Sbjct: 1486 LSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMK 1545
Query: 1068 TSLRKTDSEREEVTRAN--------ALKDE--------DAFKEEQKLKAEEGETETEVRA 1111
T L + + E + A ALK + D EE++ + + E E
Sbjct: 1546 TQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETEL 1605
Query: 1112 EEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENIT 1171
E+E K + + E ++ EL + + G + + + + F++ LE+
Sbjct: 1606 EDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDAR 1665
Query: 1172 ALRKEGGGERLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKVQAPE 1231
A R E + + + + + +E+ A E R+ + E A +
Sbjct: 1666 ASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRN 1725
Query: 1232 GLIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVD 1291
L + E A+ + +G E R ++A + AE+ E
Sbjct: 1726 ALQDEKRRLEARIAQLEEELEEEQGNMEAMSD-----RVRKATQQ-----AEQLSNELAT 1775
Query: 1292 EDPEEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAE 1351
E ++++ + E +MEG ++ + A+E A+
Sbjct: 1776 ERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFK-----STIAALE--------AK 1822
Query: 1352 TAAEEREVLAGSETAEEKTIANKASSFSD------VAEEETWHQQDELVGKTAAAGKVVV 1405
A E +V + A EK A K+ D + + E + E + A G V
Sbjct: 1823 IAQLEEQV---EQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARV 1879
Query: 1406 EELARSGEEVPAAEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEGSEGQEAATGSGDGR 1465
++L R EE AEE + A RK L +E +E +E EA GR
Sbjct: 1880 KQLKRQLEE---AEEESQRI---------NANRRK---LQRELDEATESNEAM-----GR 1919
Query: 1466 QETGAAEKFRLG 1477
+ K R G
Sbjct: 1920 EVNALKSKLRRG 1931
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 68.2 bits (165), Expect = 6e-11
Identities = 153/783 (19%), Positives = 299/783 (38%), Gaps = 97/783 (12%)
Query: 415 EKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVTAVEE 474
E+ TE+ E+ K+A+ + K ++ + K N + V + + QE++ K++ V+E
Sbjct: 1213 EELTEQLEQFKRAKANLDKNKQ-TLEKENADLAGELRVLGQ-AKQEVEHKKKKLEAQVQE 1270
Query: 475 MTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQ--SPLD 532
+ SK G+ + + K + E E G + EG+A + S L
Sbjct: 1271 LQSKCSDGERARAELNDKVHKLQNEV-----ESVTGMLNEAEGKAIKLAKDVASLSSQLQ 1325
Query: 533 DKKDNLDPEKESE----TSSQKAPDARDNVKDENDGCSES-------------ELEEDKQ 575
D ++ L E + T ++ + R++++D+ D E+ +L + K+
Sbjct: 1326 DTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK 1385
Query: 576 DMKTASST-----------SSRSHPYSSDSEDESAVGDREAHT---------DSSTDESA 615
++ +ST + E+++A D+ T D D
Sbjct: 1386 KLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN 1445
Query: 616 RRSSSQELSENDKPRKSHLPIEESLEIEIEDQ----EITKADVETKPMPIDESFENVL-- 669
+R L + + L E+++ + D+ E + ETK + + + E L
Sbjct: 1446 QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEA 1505
Query: 670 KEGTEKGTQ----EIAEGLSEKSGKHVSAEEKEKDKSKLWEESTAQVKDKKAGLPGLEEG 725
KE E+ + E+ + +S K + E EK K L Q+++ K L LE+
Sbjct: 1506 KEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRAL----ETQMEEMKTQLEELEDE 1561
Query: 726 --GKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQKTYTLEKKEAMEEDEAPQH 783
+ L + + A F D A N+E ++ +Q+ L + E EDE Q
Sbjct: 1562 LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQ--LHEYETELEDERKQR 1619
Query: 784 RDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAEGAA 843
A + K E G + + L+A + E ++ + + +R E A
Sbjct: 1620 ALAAAAKKKLE-------GDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDAR 1672
Query: 844 EAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLE-KA 902
+ ++ ++ D + L +D A ++A LE ++ A E L +
Sbjct: 1673 ASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRN 1732
Query: 903 VLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSD-VGESEEEASIDLEDTGPMED 961
L +E L +A L E E+G E A+SD V ++ ++A +
Sbjct: 1733 ALQDEKRRLEAR----IAQLEEELEEEQGNME---AMSDRVRKATQQAEQLSNELATERS 1785
Query: 962 TASKREDGSEEAI------------LGGEEPAKERKEVMRTETRLSPFTGEAEAS---RM 1006
TA K E ++ + G +K + + E +++ + E +
Sbjct: 1786 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1845
Query: 1007 QVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERP 1066
++ ++ KE L ED + +A + + R + L ++L+ A E +++R
Sbjct: 1846 AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEE--ESQRI 1903
Query: 1067 KTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDA 1126
+ RK E +E T +N + + KL+ + R + N GS+
Sbjct: 1904 NANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADGSEE 1963
Query: 1127 ENE 1129
E +
Sbjct: 1964 ETD 1966
Score = 61.6 bits (148), Expect = 6e-09
Identities = 211/1152 (18%), Positives = 418/1152 (36%), Gaps = 142/1152 (12%)
Query: 406 KPSLPKSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSA----KFSAQEI 461
KP L +R+E EE++ E +++K +E NE+KE + S K QE
Sbjct: 849 KPLLQVTRQE------EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ 902
Query: 462 KTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQADV 521
E+ EEM + ++ LE+ + +E E E +E++ + E +
Sbjct: 903 LQAETELYAEAEEMRVRLAAKKQELEE-----ILHEMEARLEEEEDRGQQLQAERKKMAQ 957
Query: 522 QMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNV---KDENDGCSESE--LEEDKQD 576
QM + + +++ + E T+ K D + D+N+ S+ LEE D
Sbjct: 958 QMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISD 1017
Query: 577 MKT--ASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHL 634
+ T A + ++ ES + + E + E D
Sbjct: 1018 LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 1077
Query: 635 PIEESLEIEIEDQEITKADVETKPM--PIDESF---ENVLKE--GTEKGTQEIAEGLSEK 687
+ +I ++ K + E + +D+ N LK+ E ++ E L +
Sbjct: 1078 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1137
Query: 688 SGKHVSAEEKEKDKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMV 747
AE++++D + E +++D +E VL
Sbjct: 1138 RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1197
Query: 748 DETAAINSNKESQQLVQKTYTLE--KKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVH 805
+ K +Q + + T LE K+ D+ Q + + GE + G+A
Sbjct: 1198 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAK--Q 1255
Query: 806 EAPLRAWKPTAEQPELAEEFTE----KREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQ 861
E + K A+ EL + ++ + E+ + + G+ EG + + +
Sbjct: 1256 EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAK 1315
Query: 862 AAA------KDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANE-----AAA 910
A +D L ++E +K + + + ++ + + L++ + A + +
Sbjct: 1316 DVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIST 1375
Query: 911 LNLEHLHEVAALREAATS----EEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKR 966
LN++ L++ A++ EEG+ + ++ + EE + + +E T ++
Sbjct: 1376 LNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDK---LEKTKNRL 1432
Query: 967 E----------DGSEEAILGGEEPAKERKEVMRTETRLSP-FTGEAEASRMQVSEGSPEE 1015
+ D + + E+ ++ +++ E +S + E + + + E +
Sbjct: 1433 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA 1492
Query: 1016 GSLAK---EAFLCKEDVEGEEMVTEAE-----ANREDDRKEILPKELDLARERRKAERPK 1067
SLA+ EA KE++E + +AE ++++D K + E + E K
Sbjct: 1493 LSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMK 1552
Query: 1068 TSLRKTDSEREEVTRAN--------ALKDE--------DAFKEEQKLKAEEGETETEVRA 1111
T L + + E + A ALK + D EE++ + + E E
Sbjct: 1553 TQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETEL 1612
Query: 1112 EEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENIT 1171
E+E K + + E ++ EL + + G + + + + F++ LE+
Sbjct: 1613 EDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDAR 1672
Query: 1172 ALRKEGGGERLSEARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEPAGKVQAPE 1231
A R E + + + + + +E+ A E R+ + E A +
Sbjct: 1673 ASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRN 1732
Query: 1232 GLIPATGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVD 1291
L + E A+ + +G E R ++A + AE+ E
Sbjct: 1733 ALQDEKRRLEARIAQLEEELEEEQGNMEAMSD-----RVRKATQQ-----AEQLSNELAT 1782
Query: 1292 EDPEEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAE 1351
E ++++ + E +MEG ++ + A+E A+
Sbjct: 1783 ERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFK-----STIAALE--------AK 1829
Query: 1352 TAAEEREVLAGSETAEEKTIANKASSFSD------VAEEETWHQQDELVGKTAAAGKVVV 1405
A E +V + A EK A K+ D + + E + E + A G V
Sbjct: 1830 IAQLEEQV---EQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARV 1886
Query: 1406 EELARSGEEVPAAEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEGSEGQEAATGSGDGR 1465
++L R EE AEE + A RK L +E +E +E EA GR
Sbjct: 1887 KQLKRQLEE---AEEESQRI---------NANRRK---LQRELDEATESNEAM-----GR 1926
Query: 1466 QETGAAEKFRLG 1477
+ K R G
Sbjct: 1927 EVNALKSKLRRG 1938
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 67.4 bits (163), Expect = 1e-10
Identities = 107/513 (20%), Positives = 198/513 (38%), Gaps = 57/513 (11%)
Query: 455 KFSAQEIKTGLKEVVTAVEEMTSKGKPGQ--EVLEDDQENTLKYEYEEDFEVDEEKQGEK 512
K A ++K K V +EE + + + E L E EE E EEK+ E
Sbjct: 440 KVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEP 499
Query: 513 SNEEGQADVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEE 572
EE + + + + + + K++ + E+E ++ D +G SE E
Sbjct: 500 EAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSS 559
Query: 573 DKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKS 632
+K++ + + +++E E A E + ++E A + ++ +KP K+
Sbjct: 560 EKEEGEQEEGET------EAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKA 613
Query: 633 HLPIEESLEIEIEDQEITKADVETK------PMPIDESFENVLKEG--TEKGTQEIAEG- 683
P+ +S E + K+ VE K P++E ++ + + EKG +++
Sbjct: 614 KSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSP 673
Query: 684 LSEKSGKHVSAEEKEKDKSKL-------WEESTAQVKD--KKAGLPGLEEGGKDSLPLAY 734
+ EK+ V E+ KSK EE +VK+ K+ + EE KD
Sbjct: 674 VEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKD------ 727
Query: 735 VLALGAPTMNFMVDETAAINSNKESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGE 794
+ ++ A + KE + V + T+ K + ++ + + Q K +
Sbjct: 728 -----------VPEKKKAESPVKE--EAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEK 774
Query: 795 AALWGEAGAVHEAPLRAWKPT-AEQPELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGE 853
GE G+ E + K + E + E K E+ + G E +GV G
Sbjct: 775 EKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNG- 833
Query: 854 GGSDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNL 913
+ + A + G K E EK + TV +K SEG G K + + +
Sbjct: 834 -----LDLSPADEKKGGDKSE--EKVVVTKTV---EKITSEGGDGATKYITKSVTVTQKV 883
Query: 914 EHLHEVAALREAATSEEGEAEGGVAVSDVGESE 946
E E + +T + + V +V +S+
Sbjct: 884 EEHEETFEEKLVSTKKVEKVTSHAIVKEVTQSD 916
Score = 65.5 bits (158), Expect = 4e-10
Identities = 109/475 (22%), Positives = 190/475 (40%), Gaps = 67/475 (14%)
Query: 907 EAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKR 966
EA L ++H + E +E ++E A++ + EE ++ ++ E+
Sbjct: 442 EAPKLKVQHKFVEEIIEETKVEDE-KSEMEEALTAI---TEELAVSMK-----EEKKEAA 492
Query: 967 EDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCK 1026
E+ EE EE A ++ V T + GE E Q E +EG+ + +A
Sbjct: 493 EEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQA---- 548
Query: 1027 EDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEVTRANAL 1086
EE +E E + E + E E + E +AE + +K + + EEV L
Sbjct: 549 -----EEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEE--KKVEEKSEEVATKEEL 601
Query: 1087 KDEDAFKEEQKLKAEEGETETEVRAEEET-KAPPNEMGSDAENEAPVEASELSDNPGLLG 1145
+ ++ +K K+ ++ E + + K+P E G ++PVE S P
Sbjct: 602 VADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPV 661
Query: 1146 EDSLKETV--VPIFE--ATPGFEKSLENITALRKEGGGERLSEARDTEHKDREELSSREN 1201
E+ K V P+ E +P + +E + + G GE+ ++ E K+ +E E
Sbjct: 662 EEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQ----KEEEEKEVKEAPKEEK 717
Query: 1202 RALKEGHRQDGEGALAAPEAEPAGKVQAPEGLIPATGQAEELAAKDHDSCAGLEGRAEGQ 1261
KE +D PE + K ++P EE A+ ++ E
Sbjct: 718 VEKKEEKPKD------VPEKK---KAESP--------VKEEAVAEVVTITKSVKVHLE-- 758
Query: 1262 GGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEEEDKECTLETEAMQD--RNSEGDGD 1319
+E E P+ EK +E+A E EEE + + +D N E +G
Sbjct: 759 ---------KETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGK 809
Query: 1320 MEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEEREVLAGSETAEEKTIANK 1374
E E T++ G GR V+ G + + A+E++ G + +EEK + K
Sbjct: 810 EEVEQETKEK---GSGREEEKGVVTNGLDL--SPADEKK---GGDKSEEKVVVTK 856
Score = 58.5 bits (140), Expect = 5e-08
Identities = 68/333 (20%), Positives = 138/333 (41%), Gaps = 26/333 (7%)
Query: 389 ERSSPCYKCIIAMGLDKKPSLPKSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKE- 447
+ S + + A+ + S+ + +KE + EK EE + E +V ++ V E+KE
Sbjct: 464 DEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEE 523
Query: 448 --NKTSVSAKFSAQEIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVD 505
K + +E G K +G +E E ++ T E+ E
Sbjct: 524 EGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAK 583
Query: 506 EEKQGEKSNEE--------GQADVQ-----MNGIPQSPLDDKKDNLDPEKESETSSQKAP 552
EEK+ E+ +EE A V+ + +P+SP+++K + P+ E K+P
Sbjct: 584 EEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKG-KSP 642
Query: 553 DARDNVKDENDG-CSESELEEDKQDMKTASSTSSRSH---PYSSDSEDESAVGDREAHTD 608
+ V+++ +S +EE + + S ++ P S E +S +
Sbjct: 643 VPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQK 702
Query: 609 SSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIEDQEITKADVETKPMPIDESFENV 668
++ + + +E E + + +P ++ E ++++ + + TK + + ++
Sbjct: 703 EEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKV-----HL 757
Query: 669 LKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDK 701
KE E+G E EK+G +EE+ DK
Sbjct: 758 EKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDK 790
Score = 40.0 bits (92), Expect = 0.017
Identities = 119/578 (20%), Positives = 216/578 (37%), Gaps = 71/578 (12%)
Query: 1000 EAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANR-EDDRKEILPKELDLAR 1058
+ +AS Q+ + +E +E E V E+ + +++ E+D + + + AR
Sbjct: 138 QKQASHAQLGDAYDQE---IRELRATLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEAR 194
Query: 1059 ERRKAERPKTSLRKTDSEREEVT-----RANALKDEDAFKEEQKLKAEEGETETEVRAEE 1113
R E +LRK E V + +L+DE AF + E + +++A
Sbjct: 195 LRDDTEAAIRALRKDIEEASLVKVELDKKVQSLQDEVAFLRSNH-EEEVADLLAQIQASH 253
Query: 1114 ETKAPPNEMGSDAENEAPVEASEL---SDNPGLLGEDSLKETVVPIFEATPGFEKSL--- 1167
T + + +D S+L SD E+ K + EA ++++
Sbjct: 254 ITVERKDYLKTDISTALKEIRSQLESHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSA 313
Query: 1168 -ENITALRKEGGGE--RLSEARDTEHKDREELSSRENR-----ALKEGHRQDGEGALAAP 1219
E I R++ + L R T+ +LS E R + + Q E L
Sbjct: 314 KEEIAEYRRQLQSKSIELESVRGTKESLERQLSDIEERHNHDLSSYQDTIQQLENELRGT 373
Query: 1220 EAEPAGKVQAPEGLIPATGQAEELAAKDHDSCAGLEGRAEGQGG------------VDVV 1267
+ E A ++ + L+ + A G E R G + +
Sbjct: 374 KWEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRPPITIS 433
Query: 1268 LRTQEAVAEEDPIMAE-KFREEAVDEDPEEEEDKEC----TLETE----AMQDRNSEGDG 1318
+ Q+ E + + KF EE ++E E+E E T TE +M++ E
Sbjct: 434 SKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAE 493
Query: 1319 DMEGEGNTQKNEGMGGG---RVVAVEVLHGGGETAETAAEEREVL----AGSETAEEKTI 1371
+ E E ++ E + A EV GE E +E E A S+ AEE
Sbjct: 494 EKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGS 553
Query: 1372 ANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEELARSGEEVPAAEEMTVTYTTEAGV 1431
+ SS + E+E + E G+ A A + +++ EEV EE+ +A V
Sbjct: 554 EKEGSSEKEEGEQEEGETEAEAEGEEAEAKE--EKKVEEKSEEVATKEEL----VADAKV 607
Query: 1432 GTPGALERKTSGLGQE--QEEGSEGQEAATGSGDGR--------QETGAAEKFRLGLSRE 1481
P E+ S + + +E+G + G+ +E G + + + +
Sbjct: 608 EKP---EKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEK 664
Query: 1482 GERELSPESLQAMATLPVKPDFTETREKQQHMVQGESE 1519
G+ +S ++ A PV E + + + +GE +
Sbjct: 665 GKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQK 702
Score = 38.5 bits (88), Expect = 0.050
Identities = 36/143 (25%), Positives = 57/143 (39%), Gaps = 4/143 (2%)
Query: 1383 EEETWHQQDELVGKT---AAAGKVVVEELARSGEEVPAAEEMTVTYTTEAGVGTPGALER 1439
E+E ++ L T A + K +E A EE P AEE V ++ V +
Sbjct: 463 EDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVA-AKKSPVKATAPEVK 521
Query: 1440 KTSGLGQEQEEGSEGQEAATGSGDGRQETGAAEKFRLGLSREGERELSPESLQAMATLPV 1499
+ G +E+E E +E G+ + E G +EK EGE+E +A
Sbjct: 522 EEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAE 581
Query: 1500 KPDFTETREKQQHMVQGESETAD 1522
+ + EK + + E AD
Sbjct: 582 AKEEKKVEEKSEEVATKEELVAD 604
>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
[Homo sapiens]
Length = 540
Score = 67.4 bits (163), Expect = 1e-10
Identities = 107/513 (20%), Positives = 198/513 (38%), Gaps = 57/513 (11%)
Query: 455 KFSAQEIKTGLKEVVTAVEEMTSKGKPGQ--EVLEDDQENTLKYEYEEDFEVDEEKQGEK 512
K A ++K K V +EE + + + E L E EE E EEK+ E
Sbjct: 64 KVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEP 123
Query: 513 SNEEGQADVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEE 572
EE + + + + + + K++ + E+E ++ D +G SE E
Sbjct: 124 EAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSS 183
Query: 573 DKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKS 632
+K++ + + +++E E A E + ++E A + ++ +KP K+
Sbjct: 184 EKEEGEQEEGET------EAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKA 237
Query: 633 HLPIEESLEIEIEDQEITKADVETK------PMPIDESFENVLKEG--TEKGTQEIAEG- 683
P+ +S E + K+ VE K P++E ++ + + EKG +++
Sbjct: 238 KSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSP 297
Query: 684 LSEKSGKHVSAEEKEKDKSKL-------WEESTAQVKD--KKAGLPGLEEGGKDSLPLAY 734
+ EK+ V E+ KSK EE +VK+ K+ + EE KD
Sbjct: 298 VEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKD------ 351
Query: 735 VLALGAPTMNFMVDETAAINSNKESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGE 794
+ ++ A + KE + V + T+ K + ++ + + Q K +
Sbjct: 352 -----------VPEKKKAESPVKE--EAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEK 398
Query: 795 AALWGEAGAVHEAPLRAWKPT-AEQPELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGE 853
GE G+ E + K + E + E K E+ + G E +GV G
Sbjct: 399 EKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNG- 457
Query: 854 GGSDPIGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNL 913
+ + A + G K E EK + TV +K SEG G K + + +
Sbjct: 458 -----LDLSPADEKKGGDKSE--EKVVVTKTV---EKITSEGGDGATKYITKSVTVTQKV 507
Query: 914 EHLHEVAALREAATSEEGEAEGGVAVSDVGESE 946
E E + +T + + V +V +S+
Sbjct: 508 EEHEETFEEKLVSTKKVEKVTSHAIVKEVTQSD 540
Score = 65.5 bits (158), Expect = 4e-10
Identities = 109/475 (22%), Positives = 190/475 (40%), Gaps = 67/475 (14%)
Query: 907 EAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKR 966
EA L ++H + E +E ++E A++ + EE ++ ++ E+
Sbjct: 66 EAPKLKVQHKFVEEIIEETKVEDE-KSEMEEALTAI---TEELAVSMK-----EEKKEAA 116
Query: 967 EDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCK 1026
E+ EE EE A ++ V T + GE E Q E +EG+ + +A
Sbjct: 117 EEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQA---- 172
Query: 1027 EDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEVTRANAL 1086
EE +E E + E + E E + E +AE + +K + + EEV L
Sbjct: 173 -----EEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEE--KKVEEKSEEVATKEEL 225
Query: 1087 KDEDAFKEEQKLKAEEGETETEVRAEEET-KAPPNEMGSDAENEAPVEASELSDNPGLLG 1145
+ ++ +K K+ ++ E + + K+P E G ++PVE S P
Sbjct: 226 VADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPV 285
Query: 1146 EDSLKETV--VPIFE--ATPGFEKSLENITALRKEGGGERLSEARDTEHKDREELSSREN 1201
E+ K V P+ E +P + +E + + G GE+ ++ E K+ +E E
Sbjct: 286 EEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQ----KEEEEKEVKEAPKEEK 341
Query: 1202 RALKEGHRQDGEGALAAPEAEPAGKVQAPEGLIPATGQAEELAAKDHDSCAGLEGRAEGQ 1261
KE +D PE + K ++P EE A+ ++ E
Sbjct: 342 VEKKEEKPKD------VPEKK---KAESP--------VKEEAVAEVVTITKSVKVHLE-- 382
Query: 1262 GGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEEEEDKECTLETEAMQD--RNSEGDGD 1319
+E E P+ EK +E+A E EEE + + +D N E +G
Sbjct: 383 ---------KETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGK 433
Query: 1320 MEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEEREVLAGSETAEEKTIANK 1374
E E T++ G GR V+ G + + A+E++ G + +EEK + K
Sbjct: 434 EEVEQETKEK---GSGREEEKGVVTNGLDL--SPADEKK---GGDKSEEKVVVTK 480
Score = 58.5 bits (140), Expect = 5e-08
Identities = 68/333 (20%), Positives = 138/333 (41%), Gaps = 26/333 (7%)
Query: 389 ERSSPCYKCIIAMGLDKKPSLPKSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKE- 447
+ S + + A+ + S+ + +KE + EK EE + E +V ++ V E+KE
Sbjct: 88 DEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEE 147
Query: 448 --NKTSVSAKFSAQEIKTGLKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVD 505
K + +E G K +G +E E ++ T E+ E
Sbjct: 148 EGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAK 207
Query: 506 EEKQGEKSNEE--------GQADVQ-----MNGIPQSPLDDKKDNLDPEKESETSSQKAP 552
EEK+ E+ +EE A V+ + +P+SP+++K + P+ E K+P
Sbjct: 208 EEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKG-KSP 266
Query: 553 DARDNVKDENDG-CSESELEEDKQDMKTASSTSSRSH---PYSSDSEDESAVGDREAHTD 608
+ V+++ +S +EE + + S ++ P S E +S +
Sbjct: 267 VPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQK 326
Query: 609 SSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIEDQEITKADVETKPMPIDESFENV 668
++ + + +E E + + +P ++ E ++++ + + TK + + ++
Sbjct: 327 EEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKV-----HL 381
Query: 669 LKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDK 701
KE E+G E EK+G +EE+ DK
Sbjct: 382 EKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDK 414
Score = 38.9 bits (89), Expect = 0.039
Identities = 60/261 (22%), Positives = 104/261 (39%), Gaps = 34/261 (13%)
Query: 1284 KFREEAVDEDPEEEEDKEC----TLETE----AMQDRNSEGDGDMEGEGNTQKNEGMGGG 1335
KF EE ++E E+E E T TE +M++ E + E E ++ E
Sbjct: 75 KFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKK 134
Query: 1336 ---RVVAVEVLHGGGETAETAAEEREVL----AGSETAEEKTIANKASSFSDVAEEETWH 1388
+ A EV GE E +E E A S+ AEE + SS + E+E
Sbjct: 135 SPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGE 194
Query: 1389 QQDELVGKTAAAGKVVVEELARSGEEVPAAEEMTVTYTTEAGVGTPGALERKTSGLGQE- 1447
+ E G+ A A + +++ EEV EE+ +A V P E+ S + +
Sbjct: 195 TEAEAEGEEAEAKE--EKKVEEKSEEVATKEEL----VADAKVEKP---EKAKSPVPKSP 245
Query: 1448 -QEEGSEGQEAATGSGDGR--------QETGAAEKFRLGLSREGERELSPESLQAMATLP 1498
+E+G + G+ +E G + + + +G+ +S ++ A P
Sbjct: 246 VEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSP 305
Query: 1499 VKPDFTETREKQQHMVQGESE 1519
V E + + + +GE +
Sbjct: 306 VPKSPVEEAKSKAEVGKGEQK 326
Score = 38.5 bits (88), Expect = 0.050
Identities = 36/143 (25%), Positives = 57/143 (39%), Gaps = 4/143 (2%)
Query: 1383 EEETWHQQDELVGKT---AAAGKVVVEELARSGEEVPAAEEMTVTYTTEAGVGTPGALER 1439
E+E ++ L T A + K +E A EE P AEE V ++ V +
Sbjct: 87 EDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVA-AKKSPVKATAPEVK 145
Query: 1440 KTSGLGQEQEEGSEGQEAATGSGDGRQETGAAEKFRLGLSREGERELSPESLQAMATLPV 1499
+ G +E+E E +E G+ + E G +EK EGE+E +A
Sbjct: 146 EEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAE 205
Query: 1500 KPDFTETREKQQHMVQGESETAD 1522
+ + EK + + E AD
Sbjct: 206 AKEEKKVEEKSEEVATKEELVAD 228
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 67.0 bits (162), Expect = 1e-10
Identities = 138/694 (19%), Positives = 254/694 (36%), Gaps = 122/694 (17%)
Query: 420 KGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKT-----GLKEVVTAVEE 474
K +E +K++GK +KE++ ++I + +S + AQ IK +K EE
Sbjct: 33 KEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLE--AQGIKADRETVAVKPTENNEEE 90
Query: 475 MTSK-----GKPGQEVLEDDQEN------------TLKYEYEEDFEVDEEKQGEKSNEEG 517
TSK G+ G++ DD ++ T K + E D++ K ++
Sbjct: 91 FTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKA 150
Query: 518 QADVQMNGIPQSPLDDKKDNLDPEKESE--TSSQKAPDARDNVKDENDGCSESELEEDKQ 575
+ Q + ++ +DN KE SS ++ D D G +++ +
Sbjct: 151 KGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGP 210
Query: 576 DMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLP 635
++++ + S + ++ ++ +RE +E A+ +E E + +K
Sbjct: 211 NIESGNEDDDASFKIKTVAQKKAEKKERERK--KRDEEKAKLRKLKEKEELETGKKDQSK 268
Query: 636 IEESLEIEIEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAE 695
+ES E+ +K V+T +P E K T ++ EG +
Sbjct: 269 QKESQRKFEEETVKSKVTVDTGVIPASEE-----KAETPTAAEDDNEG-----------D 312
Query: 696 EKEKDKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINS 755
+K+KDK K E + K+KK G T+ M + A +
Sbjct: 313 KKKKDKKKKKGEKEEKEKEKKKGP-------------------SKATVKAMQEALAKLKE 353
Query: 756 NKESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPT 815
+E Q+ ++ E+ + +EE EA + + + Q K E +
Sbjct: 354 EEERQKREEE----ERIKRLEELEAKRKEEERLEQEKRE------------------RKK 391
Query: 816 AEQPELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEA 875
++ E E ++ ++ +R A AEA +G P SKD
Sbjct: 392 QKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVP------------SKDSL 439
Query: 876 PEKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEG 935
P+K+ + DK + Q LE ++ + E + T E E
Sbjct: 440 PKKRPIY-----EDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEE 494
Query: 936 GVAVSDVGESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLS 995
D G + EA E+T +E G++ I E P +E +E E
Sbjct: 495 EEDTEDAGLDDWEAMASDEETEKVE--------GNKVHIEVKENPEEEEEEEEEEEEDEE 546
Query: 996 PFTGEAEASRMQVSEGSPEEGSLAKEAFLCK--EDVEGEEMVTEAEANREDDRKEILPKE 1053
E E + SEG E+ ++ E K + +EM +++E + +DDR
Sbjct: 547 SEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDR------- 599
Query: 1054 LDLARERRKAERPKTSLRKTDSEREEVTRANALK 1087
+E R ++ K + K E + L+
Sbjct: 600 ---TKEERAYDKAKRRIEKRRLEHSKNVNTEKLR 630
Score = 61.6 bits (148), Expect = 6e-09
Identities = 122/562 (21%), Positives = 216/562 (38%), Gaps = 110/562 (19%)
Query: 862 AAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHL----- 916
AA + G +K++ P+K + K + +Q ++ + E L+LE
Sbjct: 23 AAEIEGAGAAKEQEPQKS-------KGKKKKEKKKQDFDEDDILKELEELSLEAQGIKAD 75
Query: 917 HEVAALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKRE--------- 967
E A++ +EE G+ ++ S D D+ +ED SK +
Sbjct: 76 RETVAVKPTENNEEEFTSKDKKKK--GQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEM 133
Query: 968 -DGSEEAILGGEEPAKERKEVMRTETRLSPFTGEA-------EASRMQVSEGSPEEGSLA 1019
GS++ + P K + + ++ + + E SR+ S S +E
Sbjct: 134 YSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEF 193
Query: 1020 KEAFLCKEDVEGEEMVTEAEANREDDR-----KEILPKELDLA-RERRKAERPKTSLRKT 1073
++ ++ + + E+ EDD K + K+ + RER+K + K LRK
Sbjct: 194 LQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKL 253
Query: 1074 DSEREEVTRANALKDEDAFKEEQKLKAEEGETETEV------------RAEEETKAPPNE 1121
E+EE+ KD+ KE Q+ K EE +++V +AE T A +
Sbjct: 254 -KEKEELETGK--KDQSKQKESQR-KFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDN 309
Query: 1122 MGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFE--------------KSL 1167
G + + + E + + K TV + EA + K L
Sbjct: 310 EGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRL 369
Query: 1168 ENITALRKEGGGERLS----EARDTEHKDREELSSRENRALKEGHRQDGEGALAAPEAEP 1223
E + A RKE ERL E + + K+R+E +E + L + R+ A A +
Sbjct: 370 EELEAKRKEE--ERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQ 427
Query: 1224 AGKVQAPEG----------------LIPATGQAEELAAKDHDSCAGLEGRAEG------- 1260
A V+ P IP +++E++ + + CA +E +G
Sbjct: 428 AQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVS-ESMELCAAVEVMEQGVPEKEET 486
Query: 1261 ---------QGGVDVVLRTQEAVA---EEDPIMAEKFREEAVDEDPEEEEDKECTLETEA 1308
+ D L EA+A E + + K E V E+PEEEE++E E +
Sbjct: 487 PPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIE-VKENPEEEEEEEEEEEEDE 545
Query: 1309 MQDRNSEGDGDMEGEGNTQKNE 1330
+ E +G+ EG +++E
Sbjct: 546 ESEEEEEEEGESEGSEGDEEDE 567
Score = 61.6 bits (148), Expect = 6e-09
Identities = 149/660 (22%), Positives = 239/660 (36%), Gaps = 89/660 (13%)
Query: 473 EEMTSKGKPGQEVLEDD-QENTLKYEYEEDFEVDEEKQGEKSNEEGQADVQMNGIPQSPL 531
E SKGK +E + D E+ + E EE + E QG K++ E A
Sbjct: 36 EPQKSKGKKKKEKKKQDFDEDDILKELEE---LSLEAQGIKADRETVAV----------- 81
Query: 532 DDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSSRSHPYS 591
+N + E S+ +K + D+ND SE EDK D K+ + + YS
Sbjct: 82 -KPTENNEEEFTSKDKKKKGQKGKKQSFDDND----SEELEDK-DSKSKKTAKPKVEMYS 135
Query: 592 SDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIEDQEITK 651
+D+ + + + + S+E +N K K I S E E E +
Sbjct: 136 GSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQ 195
Query: 652 ADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSKLWEESTA- 710
+ K ++ N+ E G ++ K+ AE+KE+++ K EE
Sbjct: 196 SRKGQKKNQKNKPGPNI-----ESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKL 250
Query: 711 -QVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQKTYTL 769
++K+K+ LE G KD + + +ET ++ +
Sbjct: 251 RKLKEKEE----LETGKKDQ-------SKQKESQRKFEEETVKSKVTVDTGVIPASEEKA 299
Query: 770 EKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELA----EEF 825
E A E+D + D + KGE + + P +A A Q LA EE
Sbjct: 300 ETPTAAEDDNEGDKKKKDKKKKKGEKE--EKEKEKKKGPSKA-TVKAMQEALAKLKEEEE 356
Query: 826 TEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKD---------EAP 876
+KRE I+R E A+ + RL + + Q + L K+ EA
Sbjct: 357 RQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREAR 416
Query: 877 EKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGG 936
+ L +L+ + L K E + + L SE E
Sbjct: 417 ARAEATLKLLQAQGVEVPSKDSLPKKRPIYE----DKKRKKIPQQLESKEVSESMELCAA 472
Query: 937 VAVSDVGESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSP 996
V V + G E+E + + EDT D EA+ EE K + E + +P
Sbjct: 473 VEVMEQGVPEKEETPPPVEPEEEEDTEDAGLD-DWEAMASDEETEKVEGNKVHIEVKENP 531
Query: 997 FTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDL 1056
E E + E S EE E+ EGE +E + D+ E + E D
Sbjct: 532 EEEEEEEEEEEEDEESEEE-----------EEEEGE-----SEGSEGDEEDEKVSDEKDS 575
Query: 1057 ARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETK 1116
+ K + S +DSE + D+D KEE+ ++ + E R E +K
Sbjct: 576 GKTLDKKPSKEMS---SDSEYDS--------DDDRTKEERAY--DKAKRRIEKRRLEHSK 622
Score = 59.7 bits (143), Expect = 2e-08
Identities = 130/655 (19%), Positives = 242/655 (36%), Gaps = 93/655 (14%)
Query: 507 EKQGEKSNEEGQADVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVK---DEND 563
+KQ KS + + D+ ++ + + + KE E K ++ K DE+D
Sbjct: 3 KKQKNKSEDSTKDDIDLDALAA-----EIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDD 57
Query: 564 GCSE-SELEEDKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQE 622
E EL + Q +K T + + ++E+E D++ +S + S+E
Sbjct: 58 ILKELEELSLEAQGIKADRETVAVKP--TENNEEEFTSKDKKKKGQKGKKQSFDDNDSEE 115
Query: 623 LSEND-KPRKSHLPIEESLEIEIEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIA 681
L + D K +K+ P E +D + K + K
Sbjct: 116 LEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAK------------------------ 151
Query: 682 EGLSEKSGKHVSAEEKEKDKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAP 741
G ++KS K E+++D SK ++K++ E G + ++ +
Sbjct: 152 -GKAQKSNKKWDGSEEDEDNSK-------KIKERSRINSSGESGDESD---EFLQSRKGQ 200
Query: 742 TMNFMVDETAAINSNKESQQLVQKTYTLEKKEAMEEDEAPQHRD---ADIVQGKGEAALW 798
N I S E K T+ +K+A +++ + RD A + + K + L
Sbjct: 201 KKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEEL- 259
Query: 799 GEAGAVHEAPLRAWKPTAEQPELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDP 858
E G ++ + + E+ + + T + P E AE AE + D
Sbjct: 260 -ETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDK 318
Query: 859 IGQAAAKDAVGLSKDEAPEKQALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHE 918
+ K+ K + P K TV +A ++ ++ E+ E LE L
Sbjct: 319 KKKKGEKEEKEKEKKKGPSKA----TVKAMQEALAKLKEEEERQKREEEERIKRLEELEA 374
Query: 919 VAALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKREDGSEEAIL--- 975
E E+ E + + E+E L+ G + + + EA L
Sbjct: 375 KRKEEERLEQEKRERKK--------QKEKERKERLKKEGKLLTKSQREARARAEATLKLL 426
Query: 976 ---GGEEPAKE---RKEVMRTETRLSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDV 1029
G E P+K+ +K + + + + E+ + E L + ++ V
Sbjct: 427 QAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVS------ESMELCAAVEVMEQGV 480
Query: 1030 -EGEEMVTEAEANREDDRKEILPKELDLA---RERRKAERPKTSLR-KTDSEREEVTRAN 1084
E EE E E+D ++ + + E K E K + K + E EE
Sbjct: 481 PEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEE 540
Query: 1085 ALKDEDAFKEEQK---LKAEEGETETEVRAEEET------KAPPNEMGSDAENEA 1130
+DE++ +EE++ + EG+ E E ++E+ K P EM SD+E ++
Sbjct: 541 EEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDS 595
Score = 48.5 bits (114), Expect = 5e-05
Identities = 82/383 (21%), Positives = 147/383 (38%), Gaps = 30/383 (7%)
Query: 943 GESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAE 1002
G +++AS ++ + +RE + EE AK RK + E TG+ +
Sbjct: 215 GNEDDDASFKIKTVAQKKAEKKERERKKRD-----EEKAKLRKLKEKEELE----TGKKD 265
Query: 1003 ASRMQVSEGSPEEGSLAKEAFL----CKEDVEGEEMVTEAEANREDDRKEILPKELDLAR 1058
S+ + S+ EE ++ + + E E T AE + E D+K+ K+ +
Sbjct: 266 QSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEK 325
Query: 1059 ERRKAERPKTSLRKT-DSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKA 1117
E ++ E+ K + T + +E + + ++ +EE+++K E E E + + EE +
Sbjct: 326 EEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLE-ELEAKRKEEERLEQ 384
Query: 1118 PPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFEKSLENITALRKEG 1177
E E E E G L S +E A E +L+ + A E
Sbjct: 385 EKRERKKQKEKER----KERLKKEGKLLTKSQRE-------ARARAEATLKLLQAQGVEV 433
Query: 1178 GGERLSEARDTEHKDREELSSRENRALKE-GHRQDGEGALAAPEAEPAGKVQAPEGLIPA 1236
+ + ++D++ + KE + A+ E K + P + P
Sbjct: 434 PSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPE 493
Query: 1237 TGQAEELAAKDHDSCAGLEGRAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDPEE 1296
+ E A D + E G V + +E EE+ E+ +E +E+ EE
Sbjct: 494 EEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEE 553
Query: 1297 E---EDKECTLETEAMQDRNSEG 1316
E E E E E + D G
Sbjct: 554 EGESEGSEGDEEDEKVSDEKDSG 576
Score = 46.2 bits (108), Expect = 2e-04
Identities = 68/328 (20%), Positives = 137/328 (41%), Gaps = 32/328 (9%)
Query: 404 DKKPSLPKSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKT 463
++K P + ++ + +G++ KK + K + E+E K E K+ + + K + QE
Sbjct: 296 EEKAETPTAAEDDN--EGDKKKKDKKKKKGEKE---EKEKEKKKGPSKATVK-AMQEALA 349
Query: 464 GLKEVVTAVEEMTSKGKPGQEV--LEDDQENTLKYEYEEDFEVDEEKQGEKSNEE----- 516
LKE EE K + + + LE+ + + E E + + +KQ EK +E
Sbjct: 350 KLKE-----EEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKE 404
Query: 517 ------GQADVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESEL 570
Q + + L + P K+S +K P D + + ES+
Sbjct: 405 GKLLTKSQREARARAEATLKLLQAQGVEVPSKDS--LPKKRPIYEDKKRKKIPQQLESKE 462
Query: 571 EEDKQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPR 630
+ ++ A + P ++ + E D+ D+ +S +E +E +
Sbjct: 463 VSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEE-TEKVEGN 521
Query: 631 KSHLPIEESLEIEIEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGK 690
K H+ ++E+ E E E++E + D E++ +E E EG+E ++ + SGK
Sbjct: 522 KVHIEVKENPEEEEEEEEEEEEDEESE----EEEEEEGESEGSEGDEEDEKVSDEKDSGK 577
Query: 691 HVSAE-EKEKDKSKLWEESTAQVKDKKA 717
+ + KE ++ + K+++A
Sbjct: 578 TLDKKPSKEMSSDSEYDSDDDRTKEERA 605
Score = 39.7 bits (91), Expect = 0.023
Identities = 48/222 (21%), Positives = 92/222 (41%), Gaps = 52/222 (23%)
Query: 404 DKKPSLPKSRKEKSTEKGEELKKAEGKVRKEREYVI----------------PKRNEIKE 447
++K K RKE+ ++G+ L K++ + R E + PK+ I E
Sbjct: 388 ERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYE 447
Query: 448 NKT--SVSAKFSAQEIKTGLKEVVTAVEEMTS----------------------KGKPGQ 483
+K + + ++E+ + E+ AVE M G
Sbjct: 448 DKKRKKIPQQLESKEVSESM-ELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDW 506
Query: 484 EVLEDDQE------NTLKYEYEED-FEVDEEKQGEKSNEEGQADVQMNGIPQ-SPLDDKK 535
E + D+E N + E +E+ E +EE++ E+ +EE + + + G + S D++
Sbjct: 507 EAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEED 566
Query: 536 DNLDPEKESETSSQKAPD---ARDNVKDENDGCSESELEEDK 574
+ + EK+S + K P + D+ D +D ++ E DK
Sbjct: 567 EKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDK 608
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.305 0.125 0.340
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 62,370,281
Number of Sequences: 37866
Number of extensions: 3296965
Number of successful extensions: 25301
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 204
Number of HSP's successfully gapped in prelim test: 1291
Number of HSP's that attempted gapping in prelim test: 13142
Number of HSP's gapped (non-prelim): 8563
length of query: 1530
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1415
effective length of database: 13,892,928
effective search space: 19658493120
effective search space used: 19658493120
T: 11
A: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.9 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.