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Search of human proteins with 82799482
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|82799482 phosphodiesterase 4B isoform 2 [Homo sapiens]
(564 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|82799482 phosphodiesterase 4B isoform 2 [Homo sapiens] 1137 0.0
gi|82799486 phosphodiesterase 4B isoform 1 [Homo sapiens] 1057 0.0
gi|82799484 phosphodiesterase 4B isoform 3 [Homo sapiens] 1057 0.0
gi|32171241 phosphodiesterase 4B isoform 1 [Homo sapiens] 1057 0.0
gi|157277988 phosphodiesterase 4D isoform 1 [Homo sapiens] 828 0.0
gi|32306513 phosphodiesterase 4D isoform 2 [Homo sapiens] 828 0.0
gi|162329612 phosphodiesterase 4A isoform 3 [Homo sapiens] 800 0.0
gi|162329610 phosphodiesterase 4A isoform 2 [Homo sapiens] 800 0.0
gi|162329608 phosphodiesterase 4A isoform 1 [Homo sapiens] 800 0.0
gi|5453862 phosphodiesterase 4A isoform 4 [Homo sapiens] 736 0.0
gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens] 735 0.0
gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens] 735 0.0
gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens] 735 0.0
gi|51102295 phosphodiesterase 1A isoform 2 [Homo sapiens] 235 9e-62
gi|21361262 phosphodiesterase 1A isoform 1 [Homo sapiens] 235 9e-62
gi|4505677 phosphodiesterase 1B [Homo sapiens] 233 4e-61
gi|4826894 phosphodiesterase 1C [Homo sapiens] 231 2e-60
gi|47132537 phosphodiesterase 8A isoform 2 [Homo sapiens] 226 3e-59
gi|27734721 phosphodiesterase 8A isoform 1 [Homo sapiens] 226 3e-59
gi|71164875 phosphodiesterase 8B isoform 2 [Homo sapiens] 217 3e-56
gi|71164873 phosphodiesterase 8B isoform 4 [Homo sapiens] 217 3e-56
gi|71164869 phosphodiesterase 8B isoform 5 [Homo sapiens] 217 3e-56
gi|71164867 phosphodiesterase 8B isoform 3 [Homo sapiens] 217 3e-56
gi|26006851 phosphodiesterase 8B isoform 1 [Homo sapiens] 217 3e-56
gi|9506959 phosphodiesterase 7B [Homo sapiens] 216 3e-56
gi|24429566 phosphodiesterase 7A isoform a [Homo sapiens] 209 7e-54
gi|24429564 phosphodiesterase 7A isoform b [Homo sapiens] 193 3e-49
gi|40254434 phosphodiesterase 3B [Homo sapiens] 181 2e-45
gi|48762726 phosphodiesterase 9A isoform f [Homo sapiens] 178 1e-44
gi|48762718 phosphodiesterase 9A isoform b [Homo sapiens] 178 1e-44
>gi|82799482 phosphodiesterase 4B isoform 2 [Homo sapiens]
Length = 564
Score = 1137 bits (2940), Expect = 0.0
Identities = 564/564 (100%), Positives = 564/564 (100%)
Query: 1 MKEHGGTFSSTGISGGSGDSAMDSLQPLQPNYMPVCLFAEESYQKLAMETLEELDWCLDQ 60
MKEHGGTFSSTGISGGSGDSAMDSLQPLQPNYMPVCLFAEESYQKLAMETLEELDWCLDQ
Sbjct: 1 MKEHGGTFSSTGISGGSGDSAMDSLQPLQPNYMPVCLFAEESYQKLAMETLEELDWCLDQ 60
Query: 61 LETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPT 120
LETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPT
Sbjct: 61 LETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPT 120
Query: 121 QKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNI 180
QKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNI
Sbjct: 121 QKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNI 180
Query: 181 FNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAA 240
FNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAA
Sbjct: 181 FNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAA 240
Query: 241 DVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDE 300
DVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDE
Sbjct: 241 DVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDE 300
Query: 301 SVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTM 360
SVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTM
Sbjct: 301 SVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTM 360
Query: 361 VETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDK 420
VETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDK
Sbjct: 361 VETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDK 420
Query: 421 ERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWY 480
ERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWY
Sbjct: 421 ERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWY 480
Query: 481 QSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVID 540
QSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVID
Sbjct: 481 QSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVID 540
Query: 541 PENRDSLGETDIDIATEDKSPVDT 564
PENRDSLGETDIDIATEDKSPVDT
Sbjct: 541 PENRDSLGETDIDIATEDKSPVDT 564
>gi|82799486 phosphodiesterase 4B isoform 1 [Homo sapiens]
Length = 736
Score = 1057 bits (2734), Expect = 0.0
Identities = 531/554 (95%), Positives = 534/554 (96%), Gaps = 4/554 (0%)
Query: 11 TGISGGSGDSAMDSLQPLQPNYMPVCLFAEESYQKLAMETLEELDWCLDQLETIQTYRSV 70
T + G S + + QP P EESYQKLAMETLEELDWCLDQLETIQTYRSV
Sbjct: 187 TNLHGTSNKRSPAASQPPVSRVNP----QEESYQKLAMETLEELDWCLDQLETIQTYRSV 242
Query: 71 SEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQ 130
SEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQ
Sbjct: 243 SEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQ 302
Query: 131 QLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNR 190
QLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNR
Sbjct: 303 QLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNR 362
Query: 191 PLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLL 250
PLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLL
Sbjct: 363 PLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLL 422
Query: 251 STPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAV 310
STPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAV
Sbjct: 423 STPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAV 482
Query: 311 GFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSG 370
GFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSG
Sbjct: 483 GFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSG 542
Query: 371 VLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISP 430
VLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISP
Sbjct: 543 VLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISP 602
Query: 431 MCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSP 490
MCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSP
Sbjct: 603 MCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSP 662
Query: 491 PLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGET 550
PLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGET
Sbjct: 663 PLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGET 722
Query: 551 DIDIATEDKSPVDT 564
DIDIATEDKSPVDT
Sbjct: 723 DIDIATEDKSPVDT 736
>gi|82799484 phosphodiesterase 4B isoform 3 [Homo sapiens]
Length = 721
Score = 1057 bits (2734), Expect = 0.0
Identities = 531/554 (95%), Positives = 534/554 (96%), Gaps = 4/554 (0%)
Query: 11 TGISGGSGDSAMDSLQPLQPNYMPVCLFAEESYQKLAMETLEELDWCLDQLETIQTYRSV 70
T + G S + + QP P EESYQKLAMETLEELDWCLDQLETIQTYRSV
Sbjct: 172 TNLHGTSNKRSPAASQPPVSRVNP----QEESYQKLAMETLEELDWCLDQLETIQTYRSV 227
Query: 71 SEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQ 130
SEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQ
Sbjct: 228 SEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQ 287
Query: 131 QLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNR 190
QLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNR
Sbjct: 288 QLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNR 347
Query: 191 PLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLL 250
PLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLL
Sbjct: 348 PLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLL 407
Query: 251 STPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAV 310
STPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAV
Sbjct: 408 STPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAV 467
Query: 311 GFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSG 370
GFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSG
Sbjct: 468 GFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSG 527
Query: 371 VLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISP 430
VLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISP
Sbjct: 528 VLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISP 587
Query: 431 MCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSP 490
MCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSP
Sbjct: 588 MCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSP 647
Query: 491 PLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGET 550
PLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGET
Sbjct: 648 PLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGET 707
Query: 551 DIDIATEDKSPVDT 564
DIDIATEDKSPVDT
Sbjct: 708 DIDIATEDKSPVDT 721
>gi|32171241 phosphodiesterase 4B isoform 1 [Homo sapiens]
Length = 736
Score = 1057 bits (2734), Expect = 0.0
Identities = 531/554 (95%), Positives = 534/554 (96%), Gaps = 4/554 (0%)
Query: 11 TGISGGSGDSAMDSLQPLQPNYMPVCLFAEESYQKLAMETLEELDWCLDQLETIQTYRSV 70
T + G S + + QP P EESYQKLAMETLEELDWCLDQLETIQTYRSV
Sbjct: 187 TNLHGTSNKRSPAASQPPVSRVNP----QEESYQKLAMETLEELDWCLDQLETIQTYRSV 242
Query: 71 SEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQ 130
SEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQ
Sbjct: 243 SEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQ 302
Query: 131 QLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNR 190
QLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNR
Sbjct: 303 QLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNR 362
Query: 191 PLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLL 250
PLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLL
Sbjct: 363 PLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLL 422
Query: 251 STPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAV 310
STPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAV
Sbjct: 423 STPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAV 482
Query: 311 GFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSG 370
GFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSG
Sbjct: 483 GFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSG 542
Query: 371 VLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISP 430
VLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISP
Sbjct: 543 VLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISP 602
Query: 431 MCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSP 490
MCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSP
Sbjct: 603 MCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSP 662
Query: 491 PLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGET 550
PLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGET
Sbjct: 663 PLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGET 722
Query: 551 DIDIATEDKSPVDT 564
DIDIATEDKSPVDT
Sbjct: 723 DIDIATEDKSPVDT 736
>gi|157277988 phosphodiesterase 4D isoform 1 [Homo sapiens]
Length = 809
Score = 828 bits (2138), Expect = 0.0
Identities = 421/539 (78%), Positives = 465/539 (86%), Gaps = 15/539 (2%)
Query: 20 SAMDSLQPLQPNYM-PVC--------LFAEESYQKLAMETLEELDWCLDQLETIQTYRSV 70
+A+ +LQ P+ P+C EE+YQKLA ETLEELDWCLDQLET+QT SV
Sbjct: 241 AALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSV 300
Query: 71 SEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQ 130
SEMASNKFKRMLNRELTHLSEMSRSGNQVSE+ISNTFLDKQ++VEIPSPTQK++EKKK+
Sbjct: 301 SEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRP 360
Query: 131 QLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNR 190
M+QISGVKKLMHSSSL N+SI RFGV TE ED LAKELED+NKWGL++F +A S NR
Sbjct: 361 --MSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNR 418
Query: 191 PLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLL 250
PLT IM+ IFQERDLLKTF+I DT ITY+MTLEDHYH+DVAYHN++HAADV QSTHVLL
Sbjct: 419 PLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLL 478
Query: 251 STPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAV 310
STPAL+AVFTDLEILAAIFA+AIHDVDHPGVSNQFLINTNSELALMYND SVLENHHLAV
Sbjct: 479 STPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAV 538
Query: 311 GFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSG 370
GFKLLQEE+CDIF NLTKKQRQ+LRKMVID+VLATDMSKHM+LLADLKTMVETKKVTSSG
Sbjct: 539 GFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSG 598
Query: 371 VLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISP 430
VLLLDNY+DRIQVL+NMVHCADLSNPTK L+LYRQWTDRIMEEFF+QGD+ERERGMEISP
Sbjct: 599 VLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISP 658
Query: 431 MCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSP 490
MCDKH ASVEKSQVGFIDYIVHPLWETWADLV PDAQDILDTLEDNR WYQS IPQSPSP
Sbjct: 659 MCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSP 718
Query: 491 PLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEG----EGHSYFSSTKTLCVIDPENRD 545
D+ QG EKFQFELTL+E+ EK+ E + S +KTLC D E+ +
Sbjct: 719 APDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTE 777
>gi|32306513 phosphodiesterase 4D isoform 2 [Homo sapiens]
Length = 673
Score = 828 bits (2138), Expect = 0.0
Identities = 421/539 (78%), Positives = 465/539 (86%), Gaps = 15/539 (2%)
Query: 20 SAMDSLQPLQPNYM-PVC--------LFAEESYQKLAMETLEELDWCLDQLETIQTYRSV 70
+A+ +LQ P+ P+C EE+YQKLA ETLEELDWCLDQLET+QT SV
Sbjct: 105 AALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSV 164
Query: 71 SEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQ 130
SEMASNKFKRMLNRELTHLSEMSRSGNQVSE+ISNTFLDKQ++VEIPSPTQK++EKKK+
Sbjct: 165 SEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRP 224
Query: 131 QLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNR 190
M+QISGVKKLMHSSSL N+SI RFGV TE ED LAKELED+NKWGL++F +A S NR
Sbjct: 225 --MSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNR 282
Query: 191 PLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLL 250
PLT IM+ IFQERDLLKTF+I DT ITY+MTLEDHYH+DVAYHN++HAADV QSTHVLL
Sbjct: 283 PLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLL 342
Query: 251 STPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAV 310
STPAL+AVFTDLEILAAIFA+AIHDVDHPGVSNQFLINTNSELALMYND SVLENHHLAV
Sbjct: 343 STPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAV 402
Query: 311 GFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSG 370
GFKLLQEE+CDIF NLTKKQRQ+LRKMVID+VLATDMSKHM+LLADLKTMVETKKVTSSG
Sbjct: 403 GFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSG 462
Query: 371 VLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISP 430
VLLLDNY+DRIQVL+NMVHCADLSNPTK L+LYRQWTDRIMEEFF+QGD+ERERGMEISP
Sbjct: 463 VLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISP 522
Query: 431 MCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSP 490
MCDKH ASVEKSQVGFIDYIVHPLWETWADLV PDAQDILDTLEDNR WYQS IPQSPSP
Sbjct: 523 MCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSP 582
Query: 491 PLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEG----EGHSYFSSTKTLCVIDPENRD 545
D+ QG EKFQFELTL+E+ EK+ E + S +KTLC D E+ +
Sbjct: 583 APDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTE 641
>gi|162329612 phosphodiesterase 4A isoform 3 [Homo sapiens]
Length = 825
Score = 800 bits (2065), Expect = 0.0
Identities = 404/504 (80%), Positives = 447/504 (88%), Gaps = 19/504 (3%)
Query: 34 PVC--LFAEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSE 91
PVC +EE+ Q+LA ETLEELDWCL+QLET+QTYRSVSEMAS+KFKRMLNRELTHLSE
Sbjct: 155 PVCKATLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSE 214
Query: 92 MSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQ---------------QLMTQI 136
MSRSGNQVSEYIS TFLDKQN+VEIPSPT K+REK++ Q M+QI
Sbjct: 215 MSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQI 274
Query: 137 SGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIM 196
+G+KKLMHS+SLNN++I RFGV T+ E+ LA+ELE+LNKWGLNIF V+ Y+ R LTCIM
Sbjct: 275 TGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIM 334
Query: 197 YAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALD 256
Y IFQERDLLK FRI DT +TYM+TLEDHYH+DVAYHNSLHAADV QSTHVLL+TPALD
Sbjct: 335 YMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALD 394
Query: 257 AVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQ 316
AVFTDLEILAA+FAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQ
Sbjct: 395 AVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQ 454
Query: 317 EEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDN 376
E++CDIF NL+K+QRQ+LRKMVIDMVLATDMSKHM+LLADLKTMVETKKVTSSGVLLLDN
Sbjct: 455 EDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDN 514
Query: 377 YTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHT 436
Y+DRIQVLRNMVHCADLSNPTK LELYRQWTDRIM EFFQQGD+ERERGMEISPMCDKHT
Sbjct: 515 YSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHT 574
Query: 437 ASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQN 496
ASVEKSQVGFIDYIVHPLWETWADLV PDAQ+ILDTLEDNR+WY S I QSPSPP +E++
Sbjct: 575 ASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEES 634
Query: 497 R--DCQGLMEKFQFELTLDEEDSE 518
R L +KFQFELTL+EE+ E
Sbjct: 635 RGPGHPPLPDKFQFELTLEEEEEE 658
>gi|162329610 phosphodiesterase 4A isoform 2 [Homo sapiens]
Length = 860
Score = 800 bits (2065), Expect = 0.0
Identities = 404/504 (80%), Positives = 447/504 (88%), Gaps = 19/504 (3%)
Query: 34 PVC--LFAEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSE 91
PVC +EE+ Q+LA ETLEELDWCL+QLET+QTYRSVSEMAS+KFKRMLNRELTHLSE
Sbjct: 190 PVCKATLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSE 249
Query: 92 MSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQ---------------QLMTQI 136
MSRSGNQVSEYIS TFLDKQN+VEIPSPT K+REK++ Q M+QI
Sbjct: 250 MSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQI 309
Query: 137 SGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIM 196
+G+KKLMHS+SLNN++I RFGV T+ E+ LA+ELE+LNKWGLNIF V+ Y+ R LTCIM
Sbjct: 310 TGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIM 369
Query: 197 YAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALD 256
Y IFQERDLLK FRI DT +TYM+TLEDHYH+DVAYHNSLHAADV QSTHVLL+TPALD
Sbjct: 370 YMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALD 429
Query: 257 AVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQ 316
AVFTDLEILAA+FAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQ
Sbjct: 430 AVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQ 489
Query: 317 EEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDN 376
E++CDIF NL+K+QRQ+LRKMVIDMVLATDMSKHM+LLADLKTMVETKKVTSSGVLLLDN
Sbjct: 490 EDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDN 549
Query: 377 YTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHT 436
Y+DRIQVLRNMVHCADLSNPTK LELYRQWTDRIM EFFQQGD+ERERGMEISPMCDKHT
Sbjct: 550 YSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHT 609
Query: 437 ASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQN 496
ASVEKSQVGFIDYIVHPLWETWADLV PDAQ+ILDTLEDNR+WY S I QSPSPP +E++
Sbjct: 610 ASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEES 669
Query: 497 R--DCQGLMEKFQFELTLDEEDSE 518
R L +KFQFELTL+EE+ E
Sbjct: 670 RGPGHPPLPDKFQFELTLEEEEEE 693
>gi|162329608 phosphodiesterase 4A isoform 1 [Homo sapiens]
Length = 886
Score = 800 bits (2065), Expect = 0.0
Identities = 404/504 (80%), Positives = 447/504 (88%), Gaps = 19/504 (3%)
Query: 34 PVC--LFAEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSE 91
PVC +EE+ Q+LA ETLEELDWCL+QLET+QTYRSVSEMAS+KFKRMLNRELTHLSE
Sbjct: 216 PVCKATLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSE 275
Query: 92 MSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQ---------------QLMTQI 136
MSRSGNQVSEYIS TFLDKQN+VEIPSPT K+REK++ Q M+QI
Sbjct: 276 MSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQI 335
Query: 137 SGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIM 196
+G+KKLMHS+SLNN++I RFGV T+ E+ LA+ELE+LNKWGLNIF V+ Y+ R LTCIM
Sbjct: 336 TGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIM 395
Query: 197 YAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALD 256
Y IFQERDLLK FRI DT +TYM+TLEDHYH+DVAYHNSLHAADV QSTHVLL+TPALD
Sbjct: 396 YMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALD 455
Query: 257 AVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQ 316
AVFTDLEILAA+FAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQ
Sbjct: 456 AVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQ 515
Query: 317 EEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDN 376
E++CDIF NL+K+QRQ+LRKMVIDMVLATDMSKHM+LLADLKTMVETKKVTSSGVLLLDN
Sbjct: 516 EDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDN 575
Query: 377 YTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHT 436
Y+DRIQVLRNMVHCADLSNPTK LELYRQWTDRIM EFFQQGD+ERERGMEISPMCDKHT
Sbjct: 576 YSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHT 635
Query: 437 ASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQN 496
ASVEKSQVGFIDYIVHPLWETWADLV PDAQ+ILDTLEDNR+WY S I QSPSPP +E++
Sbjct: 636 ASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEES 695
Query: 497 R--DCQGLMEKFQFELTLDEEDSE 518
R L +KFQFELTL+EE+ E
Sbjct: 696 RGPGHPPLPDKFQFELTLEEEEEE 719
>gi|5453862 phosphodiesterase 4A isoform 4 [Homo sapiens]
Length = 647
Score = 736 bits (1900), Expect = 0.0
Identities = 370/460 (80%), Positives = 409/460 (88%), Gaps = 17/460 (3%)
Query: 76 NKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQ----- 130
++FKRMLNRELTHLSEMSRSGNQVSEYIS TFLDKQN+VEIPSPT K+REK++
Sbjct: 21 DQFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPS 80
Query: 131 ----------QLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNI 180
Q M+QI+G+KKLMHS+SLNN++I RFGV T+ E+ LA+ELE+LNKWGLNI
Sbjct: 81 QPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNI 140
Query: 181 FNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAA 240
F V+ Y+ R LTCIMY IFQERDLLK FRI DT +TYM+TLEDHYH+DVAYHNSLHAA
Sbjct: 141 FCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAA 200
Query: 241 DVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDE 300
DV QSTHVLL+TPALDAVFTDLEILAA+FAAAIHDVDHPGVSNQFLINTNSELALMYNDE
Sbjct: 201 DVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDE 260
Query: 301 SVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTM 360
SVLENHHLAVGFKLLQE++CDIF NL+K+QRQ+LRKMVIDMVLATDMSKHM+LLADLKTM
Sbjct: 261 SVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTM 320
Query: 361 VETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDK 420
VETKKVTSSGVLLLDNY+DRIQVLRNMVHCADLSNPTK LELYRQWTDRIM EFFQQGD+
Sbjct: 321 VETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDR 380
Query: 421 ERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWY 480
ERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLV PDAQ+ILDTLEDNR+WY
Sbjct: 381 ERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWY 440
Query: 481 QSMIPQSPSPPLDEQNR--DCQGLMEKFQFELTLDEEDSE 518
S I QSPSPP +E++R L +KFQFELTL+EE+ E
Sbjct: 441 YSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEE 480
>gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens]
Length = 606
Score = 735 bits (1897), Expect = 0.0
Identities = 373/516 (72%), Positives = 432/516 (83%), Gaps = 12/516 (2%)
Query: 27 PLQPNYMPVCLFAEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNREL 86
P N +P AE++ QKLA+ETL+ELDWCLDQLET+QT SV EMASNKFKR+LNREL
Sbjct: 83 PSSSNQLPP---AEDTGQKLALETLDELDWCLDQLETLQTRHSVGEMASNKFKRILNREL 139
Query: 87 THLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSS 146
THLSE SRSGNQVSEYIS TFLD+Q +VE+P T ++ Q M++ISG+ L HS+
Sbjct: 140 THLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAP-----QPMSRISGLHGLCHSA 194
Query: 147 SLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLL 206
SL++ ++ RFGV T+ E+ LAKELED NKWGL++F VA S NRPLT I+++IFQERDLL
Sbjct: 195 SLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLL 254
Query: 207 KTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILA 266
KTF+I +DT TY++ LE HYH++VAYHNSLHAADVAQSTHVLL+TPAL+AVFTDLEILA
Sbjct: 255 KTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILA 314
Query: 267 AIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNL 326
A+FA+AIHDVDHPGVSNQFLINTNSELALMYND SVLENHHLAVGFKLLQ E+CDIF NL
Sbjct: 315 ALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNL 374
Query: 327 TKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRN 386
+ KQR +LR+MVIDMVLATDMSKHM+LLADLKTMVETKKVTS GVLLLDNY+DRIQVL+N
Sbjct: 375 SAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQN 434
Query: 387 MVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGF 446
+VHCADLSNPTK L LYRQWTDRIM EFFQQGD+ERE G++ISPMCDKHTASVEKSQVGF
Sbjct: 435 LVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGF 494
Query: 447 IDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKF 506
IDYI HPLWETWADLV PDAQD+LDTLEDNR WYQS IP+SPS D N + G ++F
Sbjct: 495 IDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPS---DLTNPERDG-PDRF 550
Query: 507 QFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPE 542
QFELTL+E + E E+E EG + + L + D E
Sbjct: 551 QFELTLEEAEEEDEEEEEEGEETALAKEALELPDTE 586
>gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens]
Length = 680
Score = 735 bits (1897), Expect = 0.0
Identities = 373/516 (72%), Positives = 432/516 (83%), Gaps = 12/516 (2%)
Query: 27 PLQPNYMPVCLFAEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNREL 86
P N +P AE++ QKLA+ETL+ELDWCLDQLET+QT SV EMASNKFKR+LNREL
Sbjct: 157 PSSSNQLPP---AEDTGQKLALETLDELDWCLDQLETLQTRHSVGEMASNKFKRILNREL 213
Query: 87 THLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSS 146
THLSE SRSGNQVSEYIS TFLD+Q +VE+P T ++ Q M++ISG+ L HS+
Sbjct: 214 THLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAP-----QPMSRISGLHGLCHSA 268
Query: 147 SLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLL 206
SL++ ++ RFGV T+ E+ LAKELED NKWGL++F VA S NRPLT I+++IFQERDLL
Sbjct: 269 SLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLL 328
Query: 207 KTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILA 266
KTF+I +DT TY++ LE HYH++VAYHNSLHAADVAQSTHVLL+TPAL+AVFTDLEILA
Sbjct: 329 KTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILA 388
Query: 267 AIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNL 326
A+FA+AIHDVDHPGVSNQFLINTNSELALMYND SVLENHHLAVGFKLLQ E+CDIF NL
Sbjct: 389 ALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNL 448
Query: 327 TKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRN 386
+ KQR +LR+MVIDMVLATDMSKHM+LLADLKTMVETKKVTS GVLLLDNY+DRIQVL+N
Sbjct: 449 SAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQN 508
Query: 387 MVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGF 446
+VHCADLSNPTK L LYRQWTDRIM EFFQQGD+ERE G++ISPMCDKHTASVEKSQVGF
Sbjct: 509 LVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGF 568
Query: 447 IDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKF 506
IDYI HPLWETWADLV PDAQD+LDTLEDNR WYQS IP+SPS D N + G ++F
Sbjct: 569 IDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPS---DLTNPERDG-PDRF 624
Query: 507 QFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPE 542
QFELTL+E + E E+E EG + + L + D E
Sbjct: 625 QFELTLEEAEEEDEEEEEEGEETALAKEALELPDTE 660
>gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens]
Length = 712
Score = 735 bits (1897), Expect = 0.0
Identities = 373/516 (72%), Positives = 432/516 (83%), Gaps = 12/516 (2%)
Query: 27 PLQPNYMPVCLFAEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNREL 86
P N +P AE++ QKLA+ETL+ELDWCLDQLET+QT SV EMASNKFKR+LNREL
Sbjct: 189 PSSSNQLPP---AEDTGQKLALETLDELDWCLDQLETLQTRHSVGEMASNKFKRILNREL 245
Query: 87 THLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSS 146
THLSE SRSGNQVSEYIS TFLD+Q +VE+P T ++ Q M++ISG+ L HS+
Sbjct: 246 THLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAP-----QPMSRISGLHGLCHSA 300
Query: 147 SLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLL 206
SL++ ++ RFGV T+ E+ LAKELED NKWGL++F VA S NRPLT I+++IFQERDLL
Sbjct: 301 SLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLL 360
Query: 207 KTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILA 266
KTF+I +DT TY++ LE HYH++VAYHNSLHAADVAQSTHVLL+TPAL+AVFTDLEILA
Sbjct: 361 KTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILA 420
Query: 267 AIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNL 326
A+FA+AIHDVDHPGVSNQFLINTNSELALMYND SVLENHHLAVGFKLLQ E+CDIF NL
Sbjct: 421 ALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNL 480
Query: 327 TKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRN 386
+ KQR +LR+MVIDMVLATDMSKHM+LLADLKTMVETKKVTS GVLLLDNY+DRIQVL+N
Sbjct: 481 SAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQN 540
Query: 387 MVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGF 446
+VHCADLSNPTK L LYRQWTDRIM EFFQQGD+ERE G++ISPMCDKHTASVEKSQVGF
Sbjct: 541 LVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGF 600
Query: 447 IDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKF 506
IDYI HPLWETWADLV PDAQD+LDTLEDNR WYQS IP+SPS D N + G ++F
Sbjct: 601 IDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPS---DLTNPERDG-PDRF 656
Query: 507 QFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPE 542
QFELTL+E + E E+E EG + + L + D E
Sbjct: 657 QFELTLEEAEEEDEEEEEEGEETALAKEALELPDTE 692
>gi|51102295 phosphodiesterase 1A isoform 2 [Homo sapiens]
Length = 535
Score = 235 bits (599), Expect = 9e-62
Identities = 119/292 (40%), Positives = 182/292 (62%), Gaps = 12/292 (4%)
Query: 170 LEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHS 229
L+D++KW ++F + S L ++Y +F DL+ F+I IT+ LE Y
Sbjct: 154 LKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSK 213
Query: 230 -DVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLIN 288
YHN +HAADV Q+ H ++ + T+LEILA +FAAAIHD +H G +N F I
Sbjct: 214 YKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQ 273
Query: 289 TNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMS 348
T S++A++YND SVLENHH++ ++L+QEE +I +NL+K + LR +VI+MVL+TDMS
Sbjct: 274 TRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMS 333
Query: 349 KHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTD 408
H + +++ ++ + G+ DR + + ++H AD+S+P KS +L+ +WT
Sbjct: 334 GHFQQIKNIRNSLQQPE----GI-------DRAKTMSLILHAADISHPAKSWKLHYRWTM 382
Query: 409 RIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWAD 460
+MEEFF QGDKE E G+ SP+CD+ + V +SQ+GFID+IV P + D
Sbjct: 383 ALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTD 434
>gi|21361262 phosphodiesterase 1A isoform 1 [Homo sapiens]
Length = 545
Score = 235 bits (599), Expect = 9e-62
Identities = 119/292 (40%), Positives = 182/292 (62%), Gaps = 12/292 (4%)
Query: 170 LEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHS 229
L+D++KW ++F + S L ++Y +F DL+ F+I IT+ LE Y
Sbjct: 154 LKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSK 213
Query: 230 -DVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLIN 288
YHN +HAADV Q+ H ++ + T+LEILA +FAAAIHD +H G +N F I
Sbjct: 214 YKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQ 273
Query: 289 TNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMS 348
T S++A++YND SVLENHH++ ++L+QEE +I +NL+K + LR +VI+MVL+TDMS
Sbjct: 274 TRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMS 333
Query: 349 KHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTD 408
H + +++ ++ + G+ DR + + ++H AD+S+P KS +L+ +WT
Sbjct: 334 GHFQQIKNIRNSLQQPE----GI-------DRAKTMSLILHAADISHPAKSWKLHYRWTM 382
Query: 409 RIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWAD 460
+MEEFF QGDKE E G+ SP+CD+ + V +SQ+GFID+IV P + D
Sbjct: 383 ALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTD 434
>gi|4505677 phosphodiesterase 1B [Homo sapiens]
Length = 536
Score = 233 bits (594), Expect = 4e-61
Identities = 125/330 (37%), Positives = 198/330 (60%), Gaps = 15/330 (4%)
Query: 170 LEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHS 229
L++L+ W ++F++ + + L I++ + +L+ F+I + ++++ LE Y
Sbjct: 158 LKNLDLWCFDVFSLNQAADDHALRTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGK 217
Query: 230 -DVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLIN 288
YHN +HAADV Q+ H L + +++E+LA IFAAAIHD +H G +N F I
Sbjct: 218 YKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQ 277
Query: 289 TNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMS 348
T SE A++YND SVLENHH++ F+L+Q++ +IF+NLTK + LR +VI+MVLATDMS
Sbjct: 278 TKSECAIVYNDRSVLENHHISSVFRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMS 337
Query: 349 KHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTD 408
H + +KT ++ + D+ + L ++H AD+S+PTK ++ +WT
Sbjct: 338 CHFQQVKTMKTALQQLE-----------RIDKPKALSLLLHAADISHPTKQWLVHSRWTK 386
Query: 409 RIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQD 468
+MEEFF+QGDKE E G+ SP+CD+ + V +SQ+GFID+IV P + D+ + Q
Sbjct: 387 ALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQP 446
Query: 469 ILDTLEDNRNWYQSMIPQSPSPPLDEQNRD 498
+ D ED+++ Q Q P LD + D
Sbjct: 447 LAD--EDSKSKNQPSF-QWRQPSLDVEVGD 473
>gi|4826894 phosphodiesterase 1C [Homo sapiens]
Length = 634
Score = 231 bits (588), Expect = 2e-60
Identities = 133/397 (33%), Positives = 222/397 (55%), Gaps = 26/397 (6%)
Query: 79 KRMLNRELTHLSEMSRSG--NQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQI 136
+R+L+ E LS++ ++V +++++TF +Q + + +K R K + I
Sbjct: 81 RRLLDTE-DELSDIQSDAVPSEVRDWLASTFT-RQMGMMLRRSDEKPRFKSIVHAVQAGI 138
Query: 137 SGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIM 196
+ +S++ V + + L+D++KW ++F++ S + L I
Sbjct: 139 FVERMYRRTSNM---------VGLSYPPAVIEALKDVDKWSFDVFSLNEASGDHALKFIF 189
Query: 197 YAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDV-AYHNSLHAADVAQSTHVLLSTPAL 255
Y + DL+ F+I ++++ LE Y YHN +HAADV Q+ H LL +
Sbjct: 190 YELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGV 249
Query: 256 DAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLL 315
T+LEI A IF+AAIHD +H G +N F I T S+ A++YND SVLENHHL+ ++LL
Sbjct: 250 ANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLL 309
Query: 316 Q-EEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLL 374
Q +E +I +NL+K + R +VI+MV+ATDMS H + +KT ++ +
Sbjct: 310 QDDEEMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEA-------- 361
Query: 375 DNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDK 434
++ + L M+H AD+S+P K+ +L+ +WT ++EEFF+QGD+E E G+ SP+CD+
Sbjct: 362 ---IEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDR 418
Query: 435 HTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILD 471
+ V +SQVGFID+IV P + D+ + ++D
Sbjct: 419 KSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLID 455
>gi|47132537 phosphodiesterase 8A isoform 2 [Homo sapiens]
Length = 783
Score = 226 bits (577), Expect = 3e-59
Identities = 119/331 (35%), Positives = 193/331 (58%), Gaps = 15/331 (4%)
Query: 166 LAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLED 225
+A+ +E+ W +IF + +HNRPL + +F + + S T +++ +E
Sbjct: 442 IARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWLQIIEA 501
Query: 226 HYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQF 285
+YHS YHNS H+ADV +T LS + ++ +AA+ AA IHDVDHPG +N F
Sbjct: 502 NYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPGRTNSF 561
Query: 286 LINTNSELALMYNDESVLENHHLAVGFKLLQ-EEHCDIFMNLTKKQRQTLRKMVIDMVLA 344
L N SELA++YND +VLE+HH A+ F+L ++ C+IF N+ + +TLR+ +IDMVLA
Sbjct: 562 LCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGIIDMVLA 621
Query: 345 TDMSKHM-----------SLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADL 393
T+M+KH LA L+ ET K +L +R + R ++ CAD+
Sbjct: 622 TEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLIKCADV 681
Query: 394 SNPTKSLELYRQWTDRIMEEFFQQGDKERERGME-ISPMCDKHTASVEKSQVGFIDYIVH 452
SNP + L+ +W RI EE+F Q D+E+++G+ + P+ D++T S+ KSQ+ FIDY +
Sbjct: 682 SNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFIDYFIT 741
Query: 453 PLWETWADLVQPDAQDILDTLEDNRNWYQSM 483
+++ W V D D++ L++N +++ +
Sbjct: 742 DMFDAWDAFV--DLPDLMQHLDNNFKYWKGL 770
>gi|27734721 phosphodiesterase 8A isoform 1 [Homo sapiens]
Length = 829
Score = 226 bits (577), Expect = 3e-59
Identities = 119/331 (35%), Positives = 193/331 (58%), Gaps = 15/331 (4%)
Query: 166 LAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLED 225
+A+ +E+ W +IF + +HNRPL + +F + + S T +++ +E
Sbjct: 488 IARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWLQIIEA 547
Query: 226 HYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQF 285
+YHS YHNS H+ADV +T LS + ++ +AA+ AA IHDVDHPG +N F
Sbjct: 548 NYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPGRTNSF 607
Query: 286 LINTNSELALMYNDESVLENHHLAVGFKLLQ-EEHCDIFMNLTKKQRQTLRKMVIDMVLA 344
L N SELA++YND +VLE+HH A+ F+L ++ C+IF N+ + +TLR+ +IDMVLA
Sbjct: 608 LCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGIIDMVLA 667
Query: 345 TDMSKHM-----------SLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADL 393
T+M+KH LA L+ ET K +L +R + R ++ CAD+
Sbjct: 668 TEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLIKCADV 727
Query: 394 SNPTKSLELYRQWTDRIMEEFFQQGDKERERGME-ISPMCDKHTASVEKSQVGFIDYIVH 452
SNP + L+ +W RI EE+F Q D+E+++G+ + P+ D++T S+ KSQ+ FIDY +
Sbjct: 728 SNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFIDYFIT 787
Query: 453 PLWETWADLVQPDAQDILDTLEDNRNWYQSM 483
+++ W V D D++ L++N +++ +
Sbjct: 788 DMFDAWDAFV--DLPDLMQHLDNNFKYWKGL 816
>gi|71164875 phosphodiesterase 8B isoform 2 [Homo sapiens]
Length = 838
Score = 217 bits (552), Expect = 3e-56
Identities = 117/327 (35%), Positives = 188/327 (57%), Gaps = 18/327 (5%)
Query: 166 LAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLED 225
+++ L++ W NIF + +H RPL + +F + + S T + +E
Sbjct: 500 ISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEA 559
Query: 226 HYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQF 285
+YHS AYHNS HAADV +T L + L+ +AA+ AA +HDVDHPG +N F
Sbjct: 560 NYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSF 619
Query: 286 LINTNSELALMYNDESVLENHHLAVGFKL-LQEEHCDIFMNLTKKQRQTLRKMVIDMVLA 344
L N SELA++YND +VLE+HH A+ F+L +++ C+IF N+ + +TLR+ +IDMVLA
Sbjct: 620 LCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLA 679
Query: 345 TDMSKHM--------SLLADLKTMVETK--KVTSSGVLLLDNYTDRIQVLRNMVHCADLS 394
T+M+KH S+ + +E + +G +N +I + R M+ CAD++
Sbjct: 680 TEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPEN---QILIKRMMIKCADVA 736
Query: 395 NPTKSLELYRQWTDRIMEEFFQQGDKERERGME-ISPMCDKHTASVEKSQVGFIDYIVHP 453
NP + L+L +W RI EE+F Q D+E+ +G+ + P+ D++T S+ KSQ+ FIDY +
Sbjct: 737 NPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITD 796
Query: 454 LWETWADLVQPDAQDILDTLEDN-RNW 479
+++ W A ++ L DN ++W
Sbjct: 797 MFDAWDAFAHLPA--LMQHLADNYKHW 821
>gi|71164873 phosphodiesterase 8B isoform 4 [Homo sapiens]
Length = 865
Score = 217 bits (552), Expect = 3e-56
Identities = 117/327 (35%), Positives = 188/327 (57%), Gaps = 18/327 (5%)
Query: 166 LAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLED 225
+++ L++ W NIF + +H RPL + +F + + S T + +E
Sbjct: 527 ISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEA 586
Query: 226 HYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQF 285
+YHS AYHNS HAADV +T L + L+ +AA+ AA +HDVDHPG +N F
Sbjct: 587 NYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSF 646
Query: 286 LINTNSELALMYNDESVLENHHLAVGFKL-LQEEHCDIFMNLTKKQRQTLRKMVIDMVLA 344
L N SELA++YND +VLE+HH A+ F+L +++ C+IF N+ + +TLR+ +IDMVLA
Sbjct: 647 LCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLA 706
Query: 345 TDMSKHM--------SLLADLKTMVETK--KVTSSGVLLLDNYTDRIQVLRNMVHCADLS 394
T+M+KH S+ + +E + +G +N +I + R M+ CAD++
Sbjct: 707 TEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPEN---QILIKRMMIKCADVA 763
Query: 395 NPTKSLELYRQWTDRIMEEFFQQGDKERERGME-ISPMCDKHTASVEKSQVGFIDYIVHP 453
NP + L+L +W RI EE+F Q D+E+ +G+ + P+ D++T S+ KSQ+ FIDY +
Sbjct: 764 NPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITD 823
Query: 454 LWETWADLVQPDAQDILDTLEDN-RNW 479
+++ W A ++ L DN ++W
Sbjct: 824 MFDAWDAFAHLPA--LMQHLADNYKHW 848
>gi|71164869 phosphodiesterase 8B isoform 5 [Homo sapiens]
Length = 830
Score = 217 bits (552), Expect = 3e-56
Identities = 117/327 (35%), Positives = 188/327 (57%), Gaps = 18/327 (5%)
Query: 166 LAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLED 225
+++ L++ W NIF + +H RPL + +F + + S T + +E
Sbjct: 492 ISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEA 551
Query: 226 HYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQF 285
+YHS AYHNS HAADV +T L + L+ +AA+ AA +HDVDHPG +N F
Sbjct: 552 NYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSF 611
Query: 286 LINTNSELALMYNDESVLENHHLAVGFKL-LQEEHCDIFMNLTKKQRQTLRKMVIDMVLA 344
L N SELA++YND +VLE+HH A+ F+L +++ C+IF N+ + +TLR+ +IDMVLA
Sbjct: 612 LCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLA 671
Query: 345 TDMSKHM--------SLLADLKTMVETK--KVTSSGVLLLDNYTDRIQVLRNMVHCADLS 394
T+M+KH S+ + +E + +G +N +I + R M+ CAD++
Sbjct: 672 TEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPEN---QILIKRMMIKCADVA 728
Query: 395 NPTKSLELYRQWTDRIMEEFFQQGDKERERGME-ISPMCDKHTASVEKSQVGFIDYIVHP 453
NP + L+L +W RI EE+F Q D+E+ +G+ + P+ D++T S+ KSQ+ FIDY +
Sbjct: 729 NPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITD 788
Query: 454 LWETWADLVQPDAQDILDTLEDN-RNW 479
+++ W A ++ L DN ++W
Sbjct: 789 MFDAWDAFAHLPA--LMQHLADNYKHW 813
>gi|71164867 phosphodiesterase 8B isoform 3 [Homo sapiens]
Length = 788
Score = 217 bits (552), Expect = 3e-56
Identities = 117/327 (35%), Positives = 188/327 (57%), Gaps = 18/327 (5%)
Query: 166 LAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLED 225
+++ L++ W NIF + +H RPL + +F + + S T + +E
Sbjct: 450 ISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEA 509
Query: 226 HYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQF 285
+YHS AYHNS HAADV +T L + L+ +AA+ AA +HDVDHPG +N F
Sbjct: 510 NYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSF 569
Query: 286 LINTNSELALMYNDESVLENHHLAVGFKL-LQEEHCDIFMNLTKKQRQTLRKMVIDMVLA 344
L N SELA++YND +VLE+HH A+ F+L +++ C+IF N+ + +TLR+ +IDMVLA
Sbjct: 570 LCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLA 629
Query: 345 TDMSKHM--------SLLADLKTMVETK--KVTSSGVLLLDNYTDRIQVLRNMVHCADLS 394
T+M+KH S+ + +E + +G +N +I + R M+ CAD++
Sbjct: 630 TEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPEN---QILIKRMMIKCADVA 686
Query: 395 NPTKSLELYRQWTDRIMEEFFQQGDKERERGME-ISPMCDKHTASVEKSQVGFIDYIVHP 453
NP + L+L +W RI EE+F Q D+E+ +G+ + P+ D++T S+ KSQ+ FIDY +
Sbjct: 687 NPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITD 746
Query: 454 LWETWADLVQPDAQDILDTLEDN-RNW 479
+++ W A ++ L DN ++W
Sbjct: 747 MFDAWDAFAHLPA--LMQHLADNYKHW 771
>gi|26006851 phosphodiesterase 8B isoform 1 [Homo sapiens]
Length = 885
Score = 217 bits (552), Expect = 3e-56
Identities = 117/327 (35%), Positives = 188/327 (57%), Gaps = 18/327 (5%)
Query: 166 LAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLED 225
+++ L++ W NIF + +H RPL + +F + + S T + +E
Sbjct: 547 ISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEA 606
Query: 226 HYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQF 285
+YHS AYHNS HAADV +T L + L+ +AA+ AA +HDVDHPG +N F
Sbjct: 607 NYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSF 666
Query: 286 LINTNSELALMYNDESVLENHHLAVGFKL-LQEEHCDIFMNLTKKQRQTLRKMVIDMVLA 344
L N SELA++YND +VLE+HH A+ F+L +++ C+IF N+ + +TLR+ +IDMVLA
Sbjct: 667 LCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLA 726
Query: 345 TDMSKHM--------SLLADLKTMVETK--KVTSSGVLLLDNYTDRIQVLRNMVHCADLS 394
T+M+KH S+ + +E + +G +N +I + R M+ CAD++
Sbjct: 727 TEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPEN---QILIKRMMIKCADVA 783
Query: 395 NPTKSLELYRQWTDRIMEEFFQQGDKERERGME-ISPMCDKHTASVEKSQVGFIDYIVHP 453
NP + L+L +W RI EE+F Q D+E+ +G+ + P+ D++T S+ KSQ+ FIDY +
Sbjct: 784 NPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITD 843
Query: 454 LWETWADLVQPDAQDILDTLEDN-RNW 479
+++ W A ++ L DN ++W
Sbjct: 844 MFDAWDAFAHLPA--LMQHLADNYKHW 868
>gi|9506959 phosphodiesterase 7B [Homo sapiens]
Length = 450
Score = 216 bits (551), Expect = 3e-56
Identities = 120/366 (32%), Positives = 208/366 (56%), Gaps = 17/366 (4%)
Query: 126 KKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNK---WGLNIFN 182
KKK ++L++ ++ H+S L I + ++ +ED+L + L+K W +IF
Sbjct: 66 KKKVKRLLS----FQRYFHASRLLRGIIPQAPLHLLDEDYLGQARHMLSKVGMWDFDIFL 121
Query: 183 VAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADV 242
++ L ++ +F L+ F++ T +++ +++ YHS YHN++HAADV
Sbjct: 122 FDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVHAADV 181
Query: 243 AQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESV 302
Q+ H L P L + T L+I+ + AAA HDVDHPGV+ FLI TN LA +Y + SV
Sbjct: 182 TQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMSV 241
Query: 303 LENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVE 362
LENHH +L+E + +L K+ Q + + + ++LATD+++ L LK +
Sbjct: 242 LENHHWRSTIGMLRESR--LLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLH 299
Query: 363 TKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKER 422
K L L++ DR +L+ + CAD+ NP + E+ +QW++R+ EEF++QG+ E+
Sbjct: 300 NKD------LRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQ 353
Query: 423 ERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPD--AQDILDTLEDNRNWY 480
+ +EISP+C++ S+ Q+GF+ YIV PL+ WA ++++L L N+ +
Sbjct: 354 KFELEISPLCNQQKDSIPSIQIGFMSYIVEPLFREWAHFTGNSTLSENMLGHLAHNKAQW 413
Query: 481 QSMIPQ 486
+S++P+
Sbjct: 414 KSLLPR 419
>gi|24429566 phosphodiesterase 7A isoform a [Homo sapiens]
Length = 456
Score = 209 bits (531), Expect = 7e-54
Identities = 120/372 (32%), Positives = 199/372 (53%), Gaps = 23/372 (6%)
Query: 91 EMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNN 150
E R G+ YI Q+++E+ + R +S + L S
Sbjct: 52 ESERRGSH--PYIDFRIFHSQSEIEVSVSARNIRRL---------LSFQRYLRSSRFFRG 100
Query: 151 TSISRFGVNTENEDHLAKE---LEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLK 207
T++S +N ++D+ + LE + W +IF ++ L + + +F L++
Sbjct: 101 TAVSN-SLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIE 159
Query: 208 TFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAA 267
F + +++ +++ YHS YHN++HAADV Q+ H L P L T +IL +
Sbjct: 160 YFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLS 219
Query: 268 IFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLT 327
+ AAA HD+DHPGV+ FLI TN LA +Y + SVLENHH LL+E +F +L
Sbjct: 220 LIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRES--GLFSHLP 277
Query: 328 KKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNM 387
+ RQ + + ++LATD+S+ L+ ++ ++ G L L++ R VL+
Sbjct: 278 LESRQQMETQIGALILATDISRQNEYLSLFRSHLD------RGDLCLEDTRHRHLVLQMA 331
Query: 388 VHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFI 447
+ CAD+ NP ++ EL +QW++++ EEFF QGD E++ + +SP+CD+HT S+ Q+GF+
Sbjct: 332 LKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFM 391
Query: 448 DYIVHPLWETWA 459
Y+V PL+ WA
Sbjct: 392 TYLVEPLFTEWA 403
>gi|24429564 phosphodiesterase 7A isoform b [Homo sapiens]
Length = 424
Score = 193 bits (491), Expect = 3e-49
Identities = 114/363 (31%), Positives = 191/363 (52%), Gaps = 23/363 (6%)
Query: 91 EMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNN 150
E R G+ YI Q+++E+ + R +S + L S
Sbjct: 78 ESERRGSH--PYIDFRIFHSQSEIEVSVSARNIRRL---------LSFQRYLRSSRFFRG 126
Query: 151 TSISRFGVNTENEDHLAKE---LEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLK 207
T++S +N ++D+ + LE + W +IF ++ L + + +F L++
Sbjct: 127 TAVSN-SLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIE 185
Query: 208 TFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAA 267
F + +++ +++ YHS YHN++HAADV Q+ H L P L T +IL +
Sbjct: 186 YFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLS 245
Query: 268 IFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLT 327
+ AAA HD+DHPGV+ FLI TN LA +Y + SVLENHH LL+E +F +L
Sbjct: 246 LIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRES--GLFSHLP 303
Query: 328 KKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNM 387
+ RQ + + ++LATD+S+ L+ ++ ++ G L L++ R VL+
Sbjct: 304 LESRQQMETQIGALILATDISRQNEYLSLFRSHLD------RGDLCLEDTRHRHLVLQMA 357
Query: 388 VHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFI 447
+ CAD+ NP ++ EL +QW++++ EEFF QGD E++ + +SP+CD+HT S+ Q+G
Sbjct: 358 LKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGNY 417
Query: 448 DYI 450
Y+
Sbjct: 418 TYL 420
>gi|40254434 phosphodiesterase 3B [Homo sapiens]
Length = 1112
Score = 181 bits (458), Expect = 2e-45
Identities = 120/392 (30%), Positives = 187/392 (47%), Gaps = 60/392 (15%)
Query: 120 TQKDREKKKKQQLMTQISGVKKLMHSSSLNNTS-----ISRFGVNTENEDHLAKELEDLN 174
TQ++ E +KK G K L + + +S + E D L +E ++
Sbjct: 619 TQQEEETEKKDSRKLFQEGDKWLTEEAQSEQQTNIEQEVSLDLILVEEYDSL---IEKMS 675
Query: 175 KWGLNIFNVA---GYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDV 231
W IF + G R L+ +MY +FQ+ LL+ F+I + F+ Y LE+ Y D+
Sbjct: 676 NWNFPIFELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQFMNYFRALENGYR-DI 734
Query: 232 AYHNSLHAADVAQSTHVLLSTPA------------------------------------- 254
YHN +HA DV + L + P
Sbjct: 735 PYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSDGRINHGRIAYISSKSCSN 794
Query: 255 -------LDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHH 307
L + LE++A AAA+HD DHPG +N FL+ TN+ A++YND SVLENHH
Sbjct: 795 PDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHH 854
Query: 308 LAVGFKL-LQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKV 366
A + L L + ++L + + R +VI+ +LATD+ KH LA+ + V
Sbjct: 855 AASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNA--KANDV 912
Query: 367 TSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGM 426
S+G+ N DR+ V + + AD++ P K +L+ +WT+ I+ EF++QGD+E G+
Sbjct: 913 NSNGIEW-SNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFYEQGDEEANLGL 971
Query: 427 EISPMCDKHTASVEKSQVGFIDYIVHPLWETW 458
ISP D+ + + K Q FI +IV PL ++
Sbjct: 972 PISPFMDRSSPQLAKLQESFITHIVGPLCNSY 1003
>gi|48762726 phosphodiesterase 9A isoform f [Homo sapiens]
Length = 492
Score = 178 bits (452), Expect = 1e-44
Identities = 143/517 (27%), Positives = 257/517 (49%), Gaps = 41/517 (7%)
Query: 10 STGISGGSGDSAMDSLQPLQPNYMPVCLFAEESYQKLAMETLEELDWCLDQLETIQTYRS 69
+T IS + D AM S+ P P +E + K+ +++L ++ E IQ+ +
Sbjct: 7 NTTISLLTTDDAMVSIDPTMPAN------SERTPYKVRPVAIKQLS---EREELIQSVLA 57
Query: 70 -VSEMASNKFKRMLNRELTHLSEMSRS-GNQVSEYISNTFLDKQNDVEIPSPTQKDREKK 127
V+E S FK ++E+ N ++ L+ VEI K KK
Sbjct: 58 QVAEQFSRAFK---------INELKAEVANHLAVLEKRVELEGLKVVEIEKC--KSDIKK 106
Query: 128 KKQQLMTQISGVKKLMHSSSLNNTS--ISRFGVNTENEDHLAKE-LEDLNKWGLNIFNVA 184
+++L + S S L+N R V T + L+ E +E L K F+V
Sbjct: 107 MREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRK---PTFDVW 163
Query: 185 GYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQ 244
+ N L+C+ + ++ + L++ F I+ T ++ + D+Y ++ +HN H VAQ
Sbjct: 164 LWEPNEMLSCLEH-MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNN-PFHNFRHCFCVAQ 221
Query: 245 STHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLE 304
+ ++ +L F+ +IL + AA HD+DHPG +N + IN +ELA+ YND S LE
Sbjct: 222 MMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLE 281
Query: 305 NHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETK 364
NHH AV F++L E C+IF N+ + +R+ +I ++LATDM++H ++ K +E
Sbjct: 282 NHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENF 341
Query: 365 KVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERER 424
++ + L + ++ C D+SN + +E+ W D ++EE+F Q D+E+
Sbjct: 342 DYSNEEHMTL--------LKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE 393
Query: 425 GMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSM- 483
G+ ++P D+ + +Q+GFI +++ P++ET L + +L L ++R+ Y+ +
Sbjct: 394 GLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELK 453
Query: 484 -IPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEG 519
I + + + G EK + E + D ++SEG
Sbjct: 454 RIDDAMKELQKKTDSLTSGATEKSR-ERSRDVKNSEG 489
>gi|48762718 phosphodiesterase 9A isoform b [Homo sapiens]
Length = 533
Score = 178 bits (452), Expect = 1e-44
Identities = 143/517 (27%), Positives = 257/517 (49%), Gaps = 41/517 (7%)
Query: 10 STGISGGSGDSAMDSLQPLQPNYMPVCLFAEESYQKLAMETLEELDWCLDQLETIQTYRS 69
+T IS + D AM S+ P P +E + K+ +++L ++ E IQ+ +
Sbjct: 48 NTTISLLTTDDAMVSIDPTMPAN------SERTPYKVRPVAIKQLS---EREELIQSVLA 98
Query: 70 -VSEMASNKFKRMLNRELTHLSEMSRS-GNQVSEYISNTFLDKQNDVEIPSPTQKDREKK 127
V+E S FK ++E+ N ++ L+ VEI K KK
Sbjct: 99 QVAEQFSRAFK---------INELKAEVANHLAVLEKRVELEGLKVVEIEKC--KSDIKK 147
Query: 128 KKQQLMTQISGVKKLMHSSSLNNTS--ISRFGVNTENEDHLAKE-LEDLNKWGLNIFNVA 184
+++L + S S L+N R V T + L+ E +E L K F+V
Sbjct: 148 MREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRK---PTFDVW 204
Query: 185 GYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQ 244
+ N L+C+ + ++ + L++ F I+ T ++ + D+Y ++ +HN H VAQ
Sbjct: 205 LWEPNEMLSCLEH-MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNN-PFHNFRHCFCVAQ 262
Query: 245 STHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLE 304
+ ++ +L F+ +IL + AA HD+DHPG +N + IN +ELA+ YND S LE
Sbjct: 263 MMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLE 322
Query: 305 NHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETK 364
NHH AV F++L E C+IF N+ + +R+ +I ++LATDM++H ++ K +E
Sbjct: 323 NHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENF 382
Query: 365 KVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERER 424
++ + L + ++ C D+SN + +E+ W D ++EE+F Q D+E+
Sbjct: 383 DYSNEEHMTL--------LKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE 434
Query: 425 GMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSM- 483
G+ ++P D+ + +Q+GFI +++ P++ET L + +L L ++R+ Y+ +
Sbjct: 435 GLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELK 494
Query: 484 -IPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEG 519
I + + + G EK + E + D ++SEG
Sbjct: 495 RIDDAMKELQKKTDSLTSGATEKSR-ERSRDVKNSEG 530
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.130 0.375
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,582,847
Number of Sequences: 37866
Number of extensions: 900144
Number of successful extensions: 3435
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 68
Number of HSP's successfully gapped in prelim test: 25
Number of HSP's that attempted gapping in prelim test: 3235
Number of HSP's gapped (non-prelim): 109
length of query: 564
length of database: 18,247,518
effective HSP length: 108
effective length of query: 456
effective length of database: 14,157,990
effective search space: 6456043440
effective search space used: 6456043440
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.