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Search of human proteins with 82697315
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|82697315 RUN and FYVE domain containing 3 isoform 1 [Homo
sapiens]
(620 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|82697315 RUN and FYVE domain containing 3 isoform 1 [Homo sap... 1223 0.0
gi|7662352 RUN and FYVE domain containing 3 isoform 2 [Homo sapi... 869 0.0
gi|195220720 RUN and FYVE domain containing 3 isoform 3 [Homo sa... 746 0.0
gi|109240556 RUN and FYVE domain-containing 2 isoform a [Homo sa... 575 e-164
gi|94721330 RUN and FYVE domain-containing 1 isoform b [Homo sap... 556 e-158
gi|94721332 RUN and FYVE domain-containing 1 isoform b [Homo sap... 556 e-158
gi|94721336 RUN and FYVE domain-containing 1 isoform a [Homo sap... 556 e-158
gi|109240552 RUN and FYVE domain-containing 2 isoform b [Homo sa... 419 e-117
gi|197304746 RUN domain containing 3B isoform c [Homo sapiens] 120 5e-27
gi|197304744 RUN domain containing 3B isoform b [Homo sapiens] 118 2e-26
gi|221307580 RUN domain containing 3A isoform 3 [Homo sapiens] 113 6e-25
gi|221307578 RUN domain containing 3A isoform 1 [Homo sapiens] 108 1e-23
gi|5730015 RUN domain containing 3A isoform 2 [Homo sapiens] 108 1e-23
gi|19923090 RUN domain containing 3B isoform a [Homo sapiens] 107 3e-23
gi|157738667 FYVE and coiled-coil domain containing 1 [Homo sapi... 86 1e-16
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 78 2e-14
gi|31982906 cingulin-like 1 [Homo sapiens] 75 1e-13
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 74 4e-13
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 74 4e-13
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 74 4e-13
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 74 4e-13
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 74 4e-13
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 72 1e-12
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 72 1e-12
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 71 3e-12
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 71 3e-12
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 71 3e-12
gi|34577114 cytomatrix protein p110 [Homo sapiens] 71 3e-12
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 70 8e-12
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 69 1e-11
>gi|82697315 RUN and FYVE domain containing 3 isoform 1 [Homo
sapiens]
Length = 620
Score = 1223 bits (3165), Expect = 0.0
Identities = 620/620 (100%), Positives = 620/620 (100%)
Query: 1 MSALTPPTDMPTPTTDKITQAAMETIYLCKFRVSMDGEWLCLRELDDISLTPDPEPTHED 60
MSALTPPTDMPTPTTDKITQAAMETIYLCKFRVSMDGEWLCLRELDDISLTPDPEPTHED
Sbjct: 1 MSALTPPTDMPTPTTDKITQAAMETIYLCKFRVSMDGEWLCLRELDDISLTPDPEPTHED 60
Query: 61 PNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKK 120
PNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKK
Sbjct: 61 PNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKK 120
Query: 121 TFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYM 180
TFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYM
Sbjct: 121 TFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYM 180
Query: 181 KALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSM 240
KALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSM
Sbjct: 181 KALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSM 240
Query: 241 YLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELA 300
YLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELA
Sbjct: 241 YLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELA 300
Query: 301 VANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVE 360
VANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVE
Sbjct: 301 VANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVE 360
Query: 361 KELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVK 420
KELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVK
Sbjct: 361 KELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVK 420
Query: 421 QKSELNSRLEEKTNQMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFGDKINSLQLEVE 480
QKSELNSRLEEKTNQMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFGDKINSLQLEVE
Sbjct: 421 QKSELNSRLEEKTNQMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFGDKINSLQLEVE 480
Query: 481 ELTRQRNQLELELKQEKERRLQNDRSIPGRGSQKSESKMDGKHKMQEENVKLKKPLEESH 540
ELTRQRNQLELELKQEKERRLQNDRSIPGRGSQKSESKMDGKHKMQEENVKLKKPLEESH
Sbjct: 481 ELTRQRNQLELELKQEKERRLQNDRSIPGRGSQKSESKMDGKHKMQEENVKLKKPLEESH 540
Query: 541 RLQPHPMDEQDQLLLSEKPQLCQLCQEDGSLTKNVCKNCSGTFCDACSTNELPLPSSIKL 600
RLQPHPMDEQDQLLLSEKPQLCQLCQEDGSLTKNVCKNCSGTFCDACSTNELPLPSSIKL
Sbjct: 541 RLQPHPMDEQDQLLLSEKPQLCQLCQEDGSLTKNVCKNCSGTFCDACSTNELPLPSSIKL 600
Query: 601 ERVCNPCHKHLMKQYSTSPS 620
ERVCNPCHKHLMKQYSTSPS
Sbjct: 601 ERVCNPCHKHLMKQYSTSPS 620
>gi|7662352 RUN and FYVE domain containing 3 isoform 2 [Homo
sapiens]
Length = 469
Score = 869 bits (2246), Expect = 0.0
Identities = 445/445 (100%), Positives = 445/445 (100%)
Query: 1 MSALTPPTDMPTPTTDKITQAAMETIYLCKFRVSMDGEWLCLRELDDISLTPDPEPTHED 60
MSALTPPTDMPTPTTDKITQAAMETIYLCKFRVSMDGEWLCLRELDDISLTPDPEPTHED
Sbjct: 1 MSALTPPTDMPTPTTDKITQAAMETIYLCKFRVSMDGEWLCLRELDDISLTPDPEPTHED 60
Query: 61 PNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKK 120
PNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKK
Sbjct: 61 PNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKK 120
Query: 121 TFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYM 180
TFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYM
Sbjct: 121 TFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYM 180
Query: 181 KALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSM 240
KALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSM
Sbjct: 181 KALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSM 240
Query: 241 YLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELA 300
YLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELA
Sbjct: 241 YLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELA 300
Query: 301 VANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVE 360
VANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVE
Sbjct: 301 VANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVE 360
Query: 361 KELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVK 420
KELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVK
Sbjct: 361 KELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVK 420
Query: 421 QKSELNSRLEEKTNQMAATIKQLEQ 445
QKSELNSRLEEKTNQMAATIKQLEQ
Sbjct: 421 QKSELNSRLEEKTNQMAATIKQLEQ 445
Score = 32.0 bits (71), Expect = 1.7
Identities = 40/193 (20%), Positives = 88/193 (45%), Gaps = 7/193 (3%)
Query: 375 LAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTN 434
+ + +++ + C K + L S +D LK + K D + + + +EE
Sbjct: 213 VGLNVIDANFCMKGEDLDSQVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVEELNR 272
Query: 435 QMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFGDKINSLQLEVEELTRQRNQ-LELEL 493
+ AT+ L+ ++ E+S + +L L + ++I +LQ E+E + + + LE
Sbjct: 273 HLNATVNNLQAKVDALEKS--NTKLTEELAVAN--NRIITLQEEMERVKEESSYILESNR 328
Query: 494 KQEKERRLQNDRSI-PGRGSQKSESKMD-GKHKMQEENVKLKKPLEESHRLQPHPMDEQD 551
K K+ R +++ R K E+++ K E + +++ +E + ++ + E+
Sbjct: 329 KGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQ 388
Query: 552 QLLLSEKPQLCQL 564
L+S + QL L
Sbjct: 389 DALVSLRQQLDDL 401
>gi|195220720 RUN and FYVE domain containing 3 isoform 3 [Homo
sapiens]
Length = 506
Score = 746 bits (1925), Expect = 0.0
Identities = 386/386 (100%), Positives = 386/386 (100%)
Query: 61 PNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKK 120
PNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKK
Sbjct: 121 PNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKK 180
Query: 121 TFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYM 180
TFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYM
Sbjct: 181 TFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYM 240
Query: 181 KALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSM 240
KALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSM
Sbjct: 241 KALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSM 300
Query: 241 YLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELA 300
YLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELA
Sbjct: 301 YLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELA 360
Query: 301 VANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVE 360
VANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVE
Sbjct: 361 VANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVE 420
Query: 361 KELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVK 420
KELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVK
Sbjct: 421 KELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVK 480
Query: 421 QKSELNSRLEEKTNQMAATIKQLEQR 446
QKSELNSRLEEKTNQMAATIKQLEQR
Sbjct: 481 QKSELNSRLEEKTNQMAATIKQLEQR 506
Score = 32.0 bits (71), Expect = 1.7
Identities = 40/193 (20%), Positives = 88/193 (45%), Gaps = 7/193 (3%)
Query: 375 LAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTN 434
+ + +++ + C K + L S +D LK + K D + + + +EE
Sbjct: 273 VGLNVIDANFCMKGEDLDSQVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVEELNR 332
Query: 435 QMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFGDKINSLQLEVEELTRQRNQ-LELEL 493
+ AT+ L+ ++ E+S + +L L + ++I +LQ E+E + + + LE
Sbjct: 333 HLNATVNNLQAKVDALEKS--NTKLTEELAVAN--NRIITLQEEMERVKEESSYILESNR 388
Query: 494 KQEKERRLQNDRSI-PGRGSQKSESKMD-GKHKMQEENVKLKKPLEESHRLQPHPMDEQD 551
K K+ R +++ R K E+++ K E + +++ +E + ++ + E+
Sbjct: 389 KGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQ 448
Query: 552 QLLLSEKPQLCQL 564
L+S + QL L
Sbjct: 449 DALVSLRQQLDDL 461
>gi|109240556 RUN and FYVE domain-containing 2 isoform a [Homo
sapiens]
Length = 641
Score = 575 bits (1481), Expect = e-164
Identities = 318/597 (53%), Positives = 424/597 (71%), Gaps = 44/597 (7%)
Query: 66 ANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLGQ 125
A ER NL+NMAKLSIKGLIESAL+ GRTLDSDY PLQQFFVVMEHCLKHGLK +K+FL
Sbjct: 43 AVERANLLNMAKLSIKGLIESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLKVRKSFLSY 102
Query: 126 NKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALIN 185
NK+ WGPLELVEKL PEA EI ASV+DLPGLKTP+GR RAWLRLALMQKK+++Y++ LI
Sbjct: 103 NKTIWGPLELVEKLYPEAEEIGASVRDLPGLKTPLGRARAWLRLALMQKKMADYLRCLII 162
Query: 186 KKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKDG 245
+++LLSEFYE +ALMMEEEGA+I GLLVGLNVIDAN C+KGEDLDSQVGVIDFSMYLK+
Sbjct: 163 QRDLLSEFYEYHALMMEEEGAVIVGLLVGLNVIDANLCVKGEDLDSQVGVIDFSMYLKNE 222
Query: 246 NSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNR 305
E + QI AILDQKNYVEELNR LN+TV++L ++VD+LEKSNTKL EELA+A N
Sbjct: 223 EDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNN 282
Query: 306 IITLQEEMERVKEESSYIL--------------ESNRKGPKQDRTAEGQALSEARKHLKE 351
II LQEE +++ E+ IL E+ + K R + +EAR+ L++
Sbjct: 283 IIKLQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRD 342
Query: 352 ETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFK 411
E+QLR DVE EL +Q+SM+ E+ELAMK+LEKD+ EKQD L+ LRQQL++++A+ E+ K
Sbjct: 343 ESQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQK 402
Query: 412 LQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFGDK 471
LQ S+ G+K+K+E+ +RLEEKTN++ A ++QLEQRL+QAE+++ AE ++ + Q+ K
Sbjct: 403 LQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQRLQQAEKAQMEAEDEDEKYLQECLSK 462
Query: 472 INSLQLEVEELTRQRNQLELELKQEKERR------LQNDRSIPGRGSQKSESKMDGKHK- 524
+SLQ ++ + +Q QLE +LK EKE R LQ ++ +++ + K +
Sbjct: 463 SDSLQKQISQKEKQLVQLETDLKIEKEWRQTLQEDLQKEKDALSHLRNETQQIISLKKEF 522
Query: 525 --MQEENVKLKKPLEESH-------------RLQPHPMDEQDQLL-----LSEKPQL-CQ 563
+Q+EN +LKK E +L+ + E ++ L L +K C+
Sbjct: 523 LNLQDENQQLKKIYHEQEQALQELGNKLSESKLKIEDIKEANKALQGLVWLKDKEATHCK 582
Query: 564 LCQEDGSLT--KNVCKNCSGTFCDACSTNELPLPSSIKLERVCNPCHKHLMKQYSTS 618
LC+++ SL+ K+ C+NC FC+ACS NELPLPSS K RVC+ CH L+++ S++
Sbjct: 583 LCEKEFSLSKRKHHCRNCGEIFCNACSDNELPLPSSPKPVRVCDSCHALLIQRCSSN 639
>gi|94721330 RUN and FYVE domain-containing 1 isoform b [Homo
sapiens]
Length = 600
Score = 556 bits (1433), Expect = e-158
Identities = 303/600 (50%), Positives = 419/600 (69%), Gaps = 44/600 (7%)
Query: 65 MANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLG 124
M ER NLM+M KLSIK L++SAL+LGR+LD+D+APLQQFFVVMEHCLKHGLK KK+F+G
Sbjct: 1 MMEERANLMHMMKLSIKVLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHGLKVKKSFIG 60
Query: 125 QNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALI 184
QNKSF+GPLELVEKL PEA++I SV++LP LKT VGRGRAWL LALMQKKL++Y+K LI
Sbjct: 61 QNKSFFGPLELVEKLCPEASDIATSVRNLPELKTAVGRGRAWLYLALMQKKLADYLKVLI 120
Query: 185 NKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKD 244
+ K LLSEFYEP ALMMEEEG +I GLLVGLNV+DAN C+KGEDLDSQVGVIDFS+YLKD
Sbjct: 121 DNKHLLSEFYEPEALMMEEEGMVIVGLLVGLNVLDANLCLKGEDLDSQVGVIDFSLYLKD 180
Query: 245 GNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANN 304
G + +IT +LDQKNYVEELNRHL+ TV +LQ K+D LEK+N+KL EEL+ A +
Sbjct: 181 VQDLDGGKEHERITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATD 240
Query: 305 RIITLQEEMERVKEESSYILESNRKG---PKQDRTAEGQALSEAR-----------KHLK 350
RI +LQEE ++++E++ I E + K KQD E + + R K LK
Sbjct: 241 RICSLQEEQQQLREQNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLK 300
Query: 351 EETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAF 410
EE ++RL++EKELE+QI M+ EME+AMK+LEKD EKQD LV+LRQQL++++A+ ++
Sbjct: 301 EEKKVRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFH 360
Query: 411 KLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFGD 470
K Q+++ ++QK+E + E KTNQ+ +++KQ+E+RL+ +ER+RQ AE + +Q+ G
Sbjct: 361 KAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGG 420
Query: 471 KINSLQLEVEELTRQRNQLELELKQEKERR------LQNDR---SIPGRGSQKSESKMDG 521
+I +LQL++ +L Q + LE ELK EKE+R LQ+++ S+ Q+ E
Sbjct: 421 RIGALQLQLSQLHEQCSSLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKE 480
Query: 522 KHKMQEENVKLKKPLEESH-------------RLQPHPMDEQDQL------LLSEKPQLC 562
++Q+E +L+K EE +L+ + E +Q L ++ C
Sbjct: 481 LRELQDEKAELQKICEEQEQALQEMGLHLSQSKLKMEDIKEVNQALKGHAWLKDDEATHC 540
Query: 563 QLCQEDGSLT--KNVCKNCSGTFCDACSTNELPLPSSIKLERVCNPCHKHLMKQYSTSPS 620
+ C+++ S++ K+ C+NC FC+ CS+NEL LPS K RVC+ CH L+++ S++ S
Sbjct: 541 RQCEKEFSISRRKHHCRNCGHIFCNTCSSNELALPSYPKPVRVCDSCHTLLLQRCSSTAS 600
>gi|94721332 RUN and FYVE domain-containing 1 isoform b [Homo
sapiens]
Length = 600
Score = 556 bits (1433), Expect = e-158
Identities = 303/600 (50%), Positives = 419/600 (69%), Gaps = 44/600 (7%)
Query: 65 MANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLG 124
M ER NLM+M KLSIK L++SAL+LGR+LD+D+APLQQFFVVMEHCLKHGLK KK+F+G
Sbjct: 1 MMEERANLMHMMKLSIKVLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHGLKVKKSFIG 60
Query: 125 QNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALI 184
QNKSF+GPLELVEKL PEA++I SV++LP LKT VGRGRAWL LALMQKKL++Y+K LI
Sbjct: 61 QNKSFFGPLELVEKLCPEASDIATSVRNLPELKTAVGRGRAWLYLALMQKKLADYLKVLI 120
Query: 185 NKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKD 244
+ K LLSEFYEP ALMMEEEG +I GLLVGLNV+DAN C+KGEDLDSQVGVIDFS+YLKD
Sbjct: 121 DNKHLLSEFYEPEALMMEEEGMVIVGLLVGLNVLDANLCLKGEDLDSQVGVIDFSLYLKD 180
Query: 245 GNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANN 304
G + +IT +LDQKNYVEELNRHL+ TV +LQ K+D LEK+N+KL EEL+ A +
Sbjct: 181 VQDLDGGKEHERITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATD 240
Query: 305 RIITLQEEMERVKEESSYILESNRKG---PKQDRTAEGQALSEAR-----------KHLK 350
RI +LQEE ++++E++ I E + K KQD E + + R K LK
Sbjct: 241 RICSLQEEQQQLREQNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLK 300
Query: 351 EETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAF 410
EE ++RL++EKELE+QI M+ EME+AMK+LEKD EKQD LV+LRQQL++++A+ ++
Sbjct: 301 EEKKVRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFH 360
Query: 411 KLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFGD 470
K Q+++ ++QK+E + E KTNQ+ +++KQ+E+RL+ +ER+RQ AE + +Q+ G
Sbjct: 361 KAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGG 420
Query: 471 KINSLQLEVEELTRQRNQLELELKQEKERR------LQNDR---SIPGRGSQKSESKMDG 521
+I +LQL++ +L Q + LE ELK EKE+R LQ+++ S+ Q+ E
Sbjct: 421 RIGALQLQLSQLHEQCSSLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKE 480
Query: 522 KHKMQEENVKLKKPLEESH-------------RLQPHPMDEQDQL------LLSEKPQLC 562
++Q+E +L+K EE +L+ + E +Q L ++ C
Sbjct: 481 LRELQDEKAELQKICEEQEQALQEMGLHLSQSKLKMEDIKEVNQALKGHAWLKDDEATHC 540
Query: 563 QLCQEDGSLT--KNVCKNCSGTFCDACSTNELPLPSSIKLERVCNPCHKHLMKQYSTSPS 620
+ C+++ S++ K+ C+NC FC+ CS+NEL LPS K RVC+ CH L+++ S++ S
Sbjct: 541 RQCEKEFSISRRKHHCRNCGHIFCNTCSSNELALPSYPKPVRVCDSCHTLLLQRCSSTAS 600
>gi|94721336 RUN and FYVE domain-containing 1 isoform a [Homo
sapiens]
Length = 708
Score = 556 bits (1433), Expect = e-158
Identities = 303/600 (50%), Positives = 419/600 (69%), Gaps = 44/600 (7%)
Query: 65 MANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLG 124
M ER NLM+M KLSIK L++SAL+LGR+LD+D+APLQQFFVVMEHCLKHGLK KK+F+G
Sbjct: 109 MMEERANLMHMMKLSIKVLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHGLKVKKSFIG 168
Query: 125 QNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALI 184
QNKSF+GPLELVEKL PEA++I SV++LP LKT VGRGRAWL LALMQKKL++Y+K LI
Sbjct: 169 QNKSFFGPLELVEKLCPEASDIATSVRNLPELKTAVGRGRAWLYLALMQKKLADYLKVLI 228
Query: 185 NKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKD 244
+ K LLSEFYEP ALMMEEEG +I GLLVGLNV+DAN C+KGEDLDSQVGVIDFS+YLKD
Sbjct: 229 DNKHLLSEFYEPEALMMEEEGMVIVGLLVGLNVLDANLCLKGEDLDSQVGVIDFSLYLKD 288
Query: 245 GNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANN 304
G + +IT +LDQKNYVEELNRHL+ TV +LQ K+D LEK+N+KL EEL+ A +
Sbjct: 289 VQDLDGGKEHERITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATD 348
Query: 305 RIITLQEEMERVKEESSYILESNRKG---PKQDRTAEGQALSEAR-----------KHLK 350
RI +LQEE ++++E++ I E + K KQD E + + R K LK
Sbjct: 349 RICSLQEEQQQLREQNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLK 408
Query: 351 EETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAF 410
EE ++RL++EKELE+QI M+ EME+AMK+LEKD EKQD LV+LRQQL++++A+ ++
Sbjct: 409 EEKKVRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFH 468
Query: 411 KLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFGD 470
K Q+++ ++QK+E + E KTNQ+ +++KQ+E+RL+ +ER+RQ AE + +Q+ G
Sbjct: 469 KAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGG 528
Query: 471 KINSLQLEVEELTRQRNQLELELKQEKERR------LQNDR---SIPGRGSQKSESKMDG 521
+I +LQL++ +L Q + LE ELK EKE+R LQ+++ S+ Q+ E
Sbjct: 529 RIGALQLQLSQLHEQCSSLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKE 588
Query: 522 KHKMQEENVKLKKPLEESH-------------RLQPHPMDEQDQL------LLSEKPQLC 562
++Q+E +L+K EE +L+ + E +Q L ++ C
Sbjct: 589 LRELQDEKAELQKICEEQEQALQEMGLHLSQSKLKMEDIKEVNQALKGHAWLKDDEATHC 648
Query: 563 QLCQEDGSLT--KNVCKNCSGTFCDACSTNELPLPSSIKLERVCNPCHKHLMKQYSTSPS 620
+ C+++ S++ K+ C+NC FC+ CS+NEL LPS K RVC+ CH L+++ S++ S
Sbjct: 649 RQCEKEFSISRRKHHCRNCGHIFCNTCSSNELALPSYPKPVRVCDSCHTLLLQRCSSTAS 708
>gi|109240552 RUN and FYVE domain-containing 2 isoform b [Homo
sapiens]
Length = 403
Score = 419 bits (1077), Expect = e-117
Identities = 228/394 (57%), Positives = 282/394 (71%), Gaps = 48/394 (12%)
Query: 66 ANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLGQ 125
A ER NL+NMAKLSIKGLIESAL+ GRTLDSDY PLQQFFVVMEHCLKHGLK +K+FL
Sbjct: 8 AVERANLLNMAKLSIKGLIESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLKVRKSFLSY 67
Query: 126 NKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALIN 185
NK+ WGPLELVEKL PEA EI ASV+DLPGL
Sbjct: 68 NKTIWGPLELVEKLYPEAEEIGASVRDLPGL----------------------------- 98
Query: 186 KKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKDG 245
+EFYE +ALMMEEEGA+I GLLVGLNVIDAN C+KGEDLDSQVGVIDFSMYLK+
Sbjct: 99 -----NEFYEYHALMMEEEGAVIVGLLVGLNVIDANLCVKGEDLDSQVGVIDFSMYLKNE 153
Query: 246 NSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNR 305
E + QI AILDQKNYVEELNR LN+TV++L ++VD+LEKSNTKL EELA+A N
Sbjct: 154 EDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNN 213
Query: 306 IITLQEEMERVKEESSYIL--------------ESNRKGPKQDRTAEGQALSEARKHLKE 351
II LQEE +++ E+ IL E+ + K R + +EAR+ L++
Sbjct: 214 IIKLQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRD 273
Query: 352 ETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFK 411
E+QLR DVE EL +Q+SM+ E+ELAMK+LEKD+ EKQD L+ LRQQL++++A+ E+ K
Sbjct: 274 ESQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQK 333
Query: 412 LQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQ 445
LQ S+ G+K+K+E+ +RLEEKTN++ A ++QLEQ
Sbjct: 334 LQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQ 367
Score = 30.4 bits (67), Expect = 5.1
Identities = 40/201 (19%), Positives = 87/201 (43%), Gaps = 15/201 (7%)
Query: 375 LAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTN 434
+ + +++ ++C K + L S +D LK+E + ++ + + + +EE
Sbjct: 121 VGLNVIDANLCVKGEDLDSQVGVIDFSMYLKNEEDIGNKERNVQIAAILDQKNYVEELNR 180
Query: 435 QMAATIKQLEQRLRQAERS-----RQSAELDNRLFK-QDFGDKINS-----LQLEVEELT 483
Q+ +T+ L R+ E+S + A N + K Q+ ++ S L + L
Sbjct: 181 QLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNIIKLQEENHQLRSENKLILMKTQQHLE 240
Query: 484 RQRNQLELELKQEKERRLQNDRSIPGRGSQ---KSESKMDGKHKMQEENVKLKKPLEESH 540
+ +E EL+ K R D Q +S+ + D ++++ + V +K +E +
Sbjct: 241 VTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQLRQDVENELAVQ-VSMKHEIELAM 299
Query: 541 RLQPHPMDEQDQLLLSEKPQL 561
+L + E+ L+ + QL
Sbjct: 300 KLLEKDIHEKQDTLIGLRQQL 320
>gi|197304746 RUN domain containing 3B isoform c [Homo sapiens]
Length = 407
Score = 120 bits (300), Expect = 5e-27
Identities = 101/362 (27%), Positives = 170/362 (46%), Gaps = 46/362 (12%)
Query: 66 ANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLGQ 125
A ER NL+ + + S+K LI+ + T+D F ++E L H LK + T+ G
Sbjct: 30 AVERRNLITVCRFSVKTLIDRSCF--ETIDDSSPEFNNFAAILEQILSHRLKGQVTWFGY 87
Query: 126 N--KSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKAL 183
+SFW + + + V + S++++ + + +GRAW+R+ALM+K LSEY+
Sbjct: 88 ESPRSFWDYIRVACRKVSQ--NCICSIENMENVSSSRAKGRAWIRVALMEKHLSEYISTA 145
Query: 184 INKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLD-SQVGVIDFSMYL 242
+ + FYE A+++ EE ++AG+L+GLN ID +FC+KGE LD S VID++ YL
Sbjct: 146 LRDFKTTRRFYEDGAIVLGEEANMLAGMLLGLNAIDFSFCLKGEGLDGSFPAVIDYTPYL 205
Query: 243 KDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVA 302
K SS D EEL T+ + ++ E +
Sbjct: 206 KYIQSSDSISSD------------EEELR-----TLGSSGSESSTPENVGPPFLMDENSW 248
Query: 303 NNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKE 362
N+ ++++ + E+ Y+ E R ++++ +E + ++ E++ L +EKE
Sbjct: 249 FNKCKRVKQKYQLTLEQKGYLEELLRL--RENQLSESVSQNKILLQRIEDSDLAHKLEKE 306
Query: 363 LEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQK 422
LE + E QD L S Q LD L A E++ S D G Q+
Sbjct: 307 ----------------QLEYIIVELQDQLKSY-QSLDQLSA---EVSLSQTSLDPGQSQE 346
Query: 423 SE 424
+
Sbjct: 347 GD 348
>gi|197304744 RUN domain containing 3B isoform b [Homo sapiens]
Length = 456
Score = 118 bits (295), Expect = 2e-26
Identities = 68/192 (35%), Positives = 108/192 (56%), Gaps = 7/192 (3%)
Query: 66 ANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLGQ 125
A ER NL+ + + S+K LI+ + T+D F ++E L H LK + T+ G
Sbjct: 30 AVERRNLITVCRFSVKTLIDRSCF--ETIDDSSPEFNNFAAILEQILSHRLKGQVTWFGY 87
Query: 126 N--KSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKAL 183
+SFW + + + V + S++++ + + +GRAW+R+ALM+K LSEY+
Sbjct: 88 ESPRSFWDYIRVACRKVSQ--NCICSIENMENVSSSRAKGRAWIRVALMEKHLSEYISTA 145
Query: 184 INKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLD-SQVGVIDFSMYL 242
+ + FYE A+++ EE ++AG+L+GLN ID +FC+KGE LD S VID++ YL
Sbjct: 146 LRDFKTTRRFYEDGAIVLGEEANMLAGMLLGLNAIDFSFCLKGEGLDGSFPAVIDYTPYL 205
Query: 243 KDGNSSKGTEGD 254
K SS D
Sbjct: 206 KYIQSSDSISSD 217
Score = 30.0 bits (66), Expect = 6.6
Identities = 28/97 (28%), Positives = 47/97 (48%), Gaps = 8/97 (8%)
Query: 413 QSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFGDKI 472
Q L ++QK L L + NQ++ ++ Q + L++ E S +L ++L K+ I
Sbjct: 257 QKYQLTLEQKGYLEELLRLRENQLSESVSQNKILLQRIEDS----DLAHKLEKEQLEYII 312
Query: 473 NSLQLEVEELTRQRNQLELELKQEKERRLQNDRSIPG 509
LQ ++LT +N +L +QE L N PG
Sbjct: 313 VELQ---DQLTVLKNN-DLRSRQELTAHLTNQWPSPG 345
>gi|221307580 RUN domain containing 3A isoform 3 [Homo sapiens]
Length = 400
Score = 113 bits (282), Expect = 6e-25
Identities = 81/298 (27%), Positives = 136/298 (45%), Gaps = 57/298 (19%)
Query: 65 MANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLG 124
+A ER NL+ + + S+K L+E +D F ++E L H K ++
Sbjct: 24 VAVERKNLITVCRFSVKTLLEKYT--AEPIDDSSEEFVNFAAILEQILSHRFKGPVSWFS 81
Query: 125 QN--KSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKA 182
+ + FW + L VP +S++++ + T +GRAW+R+ALM+K++SEY+
Sbjct: 82 SDGQRGFWDYIRLACSKVPN--NCVSSIENMENISTARAKGRAWIRVALMEKRMSEYITT 139
Query: 183 LINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVG-VIDFSMY 241
+ FY+ A+M+ +E I+ G+L+GL+ ID +FC+KGE LD + VID++ Y
Sbjct: 140 ALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAIDFSFCLKGEVLDGKTPVVIDYTPY 199
Query: 242 LK--------------------------------------DGNSSKGTEGDGQITAILDQ 263
LK D SK + + + + Q
Sbjct: 200 LKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYSKWHKMEQKFRIVYAQ 259
Query: 264 KNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNR--------IITLQEEM 313
K Y+EEL R + + +L+A+ L+ EE A N R I+ LQE++
Sbjct: 260 KGYLEELVRLRESQLKDLEAENRRLQLQ----LEEAAAQNQREKRELEGVILELQEQL 313
>gi|221307578 RUN domain containing 3A isoform 1 [Homo sapiens]
Length = 446
Score = 108 bits (270), Expect = 1e-23
Identities = 84/304 (27%), Positives = 137/304 (45%), Gaps = 64/304 (21%)
Query: 65 MANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKK---- 120
+A ER NL+ + + S+K L+E +D F ++E L H KA
Sbjct: 24 VAVERKNLITVCRFSVKTLLEKYT--AEPIDDSSEEFVNFAAILEQILSHRFKACAPAGP 81
Query: 121 ----TFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKL 176
+ GQ + FW + L VP +S++++ + T +GRAW+R+ALM+K++
Sbjct: 82 VSWFSSDGQ-RGFWDYIRLACSKVPN--NCVSSIENMENISTARAKGRAWIRVALMEKRM 138
Query: 177 SEYMKALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVG-V 235
SEY+ + FY+ A+M+ +E I+ G+L+GL+ ID +FC+KGE LD + V
Sbjct: 139 SEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAIDFSFCLKGEVLDGKTPVV 198
Query: 236 IDFSMYLK--------------------------------------DGNSSKGTEGDGQI 257
ID++ YLK D SK + + +
Sbjct: 199 IDYTPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYSKWHKMEQKF 258
Query: 258 TAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNR--------IITL 309
+ QK Y+EEL R + + +L+A+ L+ EE A N R I+ L
Sbjct: 259 RIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQ----LEEAAAQNQREKRELEGVILEL 314
Query: 310 QEEM 313
QE++
Sbjct: 315 QEQL 318
>gi|5730015 RUN domain containing 3A isoform 2 [Homo sapiens]
Length = 405
Score = 108 bits (270), Expect = 1e-23
Identities = 84/304 (27%), Positives = 137/304 (45%), Gaps = 64/304 (21%)
Query: 65 MANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKK---- 120
+A ER NL+ + + S+K L+E +D F ++E L H KA
Sbjct: 24 VAVERKNLITVCRFSVKTLLEKYT--AEPIDDSSEEFVNFAAILEQILSHRFKACAPAGP 81
Query: 121 ----TFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKL 176
+ GQ + FW + L VP +S++++ + T +GRAW+R+ALM+K++
Sbjct: 82 VSWFSSDGQ-RGFWDYIRLACSKVPN--NCVSSIENMENISTARAKGRAWIRVALMEKRM 138
Query: 177 SEYMKALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVG-V 235
SEY+ + FY+ A+M+ +E I+ G+L+GL+ ID +FC+KGE LD + V
Sbjct: 139 SEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAIDFSFCLKGEVLDGKTPVV 198
Query: 236 IDFSMYLK--------------------------------------DGNSSKGTEGDGQI 257
ID++ YLK D SK + + +
Sbjct: 199 IDYTPYLKFTQSYDYLTDEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYSKWHKMEQKF 258
Query: 258 TAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNR--------IITL 309
+ QK Y+EEL R + + +L+A+ L+ EE A N R I+ L
Sbjct: 259 RIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQ----LEEAAAQNQREKRELEGVILEL 314
Query: 310 QEEM 313
QE++
Sbjct: 315 QEQL 318
>gi|19923090 RUN domain containing 3B isoform a [Homo sapiens]
Length = 473
Score = 107 bits (267), Expect = 3e-23
Identities = 68/209 (32%), Positives = 108/209 (51%), Gaps = 24/209 (11%)
Query: 66 ANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLK-------- 117
A ER NL+ + + S+K LI+ + T+D F ++E L H LK
Sbjct: 30 AVERRNLITVCRFSVKTLIDRSCF--ETIDDSSPEFNNFAAILEQILSHRLKEISQSCRW 87
Query: 118 ---------AKKTFLGQN--KSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAW 166
+ T+ G +SFW + + + V + S++++ + + +GRAW
Sbjct: 88 LAHLQIPLQGQVTWFGYESPRSFWDYIRVACRKVSQ--NCICSIENMENVSSSRAKGRAW 145
Query: 167 LRLALMQKKLSEYMKALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKG 226
+R+ALM+K LSEY+ + + FYE A+++ EE ++AG+L+GLN ID +FC+KG
Sbjct: 146 IRVALMEKHLSEYISTALRDFKTTRRFYEDGAIVLGEEANMLAGMLLGLNAIDFSFCLKG 205
Query: 227 EDLD-SQVGVIDFSMYLKDGNSSKGTEGD 254
E LD S VID++ YLK SS D
Sbjct: 206 EGLDGSFPAVIDYTPYLKYIQSSDSISSD 234
Score = 30.0 bits (66), Expect = 6.6
Identities = 28/97 (28%), Positives = 47/97 (48%), Gaps = 8/97 (8%)
Query: 413 QSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFGDKI 472
Q L ++QK L L + NQ++ ++ Q + L++ E S +L ++L K+ I
Sbjct: 274 QKYQLTLEQKGYLEELLRLRENQLSESVSQNKILLQRIEDS----DLAHKLEKEQLEYII 329
Query: 473 NSLQLEVEELTRQRNQLELELKQEKERRLQNDRSIPG 509
LQ ++LT +N +L +QE L N PG
Sbjct: 330 VELQ---DQLTVLKNN-DLRSRQELTAHLTNQWPSPG 362
>gi|157738667 FYVE and coiled-coil domain containing 1 [Homo
sapiens]
Length = 1478
Score = 85.5 bits (210), Expect = 1e-16
Identities = 119/525 (22%), Positives = 226/525 (43%), Gaps = 60/525 (11%)
Query: 91 GRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLGQNKSFWGPLELVEKLVPEAAEITASV 150
G + D L +F +E+ L+ K K T LG K +W V A + V
Sbjct: 32 GEPITDDSTSLHKFSYKLEYLLQFDQKEKATLLGNKKDYWDYFCACLAKVKGANDGIRFV 91
Query: 151 KDLPGLKTPVGRGRAWLRLALMQKKLSEYM-KALINKKELLSEFYEPNALMMEEEGAIIA 209
K + L+T +G+GRA++R +L+ ++L++ + + +N K +Y + + + + I
Sbjct: 92 KSISELRTSLGKGRAFIRYSLVHQRLADTLQQCFMNTKVTSDWYYARSPFLQPKLSSDIV 151
Query: 210 GLLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKDGNSS---KGTEGDGQITAILDQKNY 266
G L L + + +G DLD+ L G+S+ K +++++
Sbjct: 152 GQLYELTEVQFDLASRGFDLDAAWPTF-ARRTLTTGSSAYLWKPPSRSSSMSSLVSSYLQ 210
Query: 267 VEEL--NRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYIL 324
+E+ N LN+ +NN +ALE + ++ EL R L+E M+++ E+ +
Sbjct: 211 TQEMVSNFDLNSPLNN-----EALEGFD-EMRLELDQLEVREKQLRERMQQLDRENQELR 264
Query: 325 ESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMR---QEMELAMKMLE 381
+ + +Q +T + + A +++ T L +++K+ E+ + + +E++ ++ LE
Sbjct: 265 AAVSQQGEQLQTERERGRTAAEDNVR-LTCLVAELQKQWEVTQATQNTVKELQTCLQGLE 323
Query: 382 KDVCEK-QDALVSLRQQLDDLRALKHELAFKLQSSD------------LGVKQK-----S 423
EK +D +LR+ L+ L EL S D L + Q+ S
Sbjct: 324 LGAAEKEEDYHTALRRLESMLQPLAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTAS 383
Query: 424 ELNSRLEEKTNQMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFGDKINSLQLE----- 478
+ R E + A +++L ++L+ ER R E NR + LQL+
Sbjct: 384 DTKGRQEPIPSDAAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARA 443
Query: 479 -VEELTRQRNQLELELK---QEKE---RRLQNDRSIPGRGSQKSESKMDGKHKMQEENVK 531
+E L ++ L+ EL QE + RRLQ + ++ K + QEE
Sbjct: 444 SLERLVKEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKEL 503
Query: 532 LKKPLEESHR-----------LQPH--PMDEQDQLLLSEKPQLCQ 563
L++ + R + H ++EQ + L+ +K L Q
Sbjct: 504 LEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQ 548
Score = 54.7 bits (130), Expect = 3e-07
Identities = 70/360 (19%), Positives = 145/360 (40%), Gaps = 23/360 (6%)
Query: 259 AILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKE 318
A L+ E+L+R N L +V AL ++ E LA A + +E R +E
Sbjct: 887 AQLEHAELQEQLHR-ANTDTAELGIQVCALTVEKERVEEALACAVQELQDAKEAASRERE 945
Query: 319 ESSYILESNRKGPKQDRTAEGQALSEARKHLKE----ETQLRLDVEKELEMQISMRQEME 374
LE G +Q++ + + L A+ + QL ++ +Q + QE+
Sbjct: 946 G----LERQVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELN 1001
Query: 375 LAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTN 434
L ++ + Q L + ++ LR E +LQ+++ V++ + + EK +
Sbjct: 1002 TLKFQLSAEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMGEKLS 1061
Query: 435 QMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFGDKINSLQLEVEELTRQRNQLELELK 494
+ + + + + + ++ + D + Q E+E+ T + + +L
Sbjct: 1062 CTSNHLAECQAAMLRKDKEGAALRED-----------LERTQKELEKATTKIQEYYNKLC 1110
Query: 495 QEKERRLQNDRSIPGRGSQKSESKMDGKHKMQEENVKLKKPLEESHRLQ-PHPMDEQDQL 553
QE R +ND+ + + +K + ++ E ++S L+ + +++
Sbjct: 1111 QEVTNRERNDQKMLADLDDLNRTKKYLEERLIELLRDKDALWQKSDALEFQQKLSAEERW 1170
Query: 554 LLSEKPQLCQLCQEDGS--LTKNVCKNCSGTFCDACSTNELPLPSSIKLERVCNPCHKHL 611
L + C C+ + S + ++ C+ C FC C N + K ER C C + L
Sbjct: 1171 LGDTEANHCLDCKREFSWMVRRHHCRICGRIFCYYCCNNYVLSKHGGKKERCCRACFQKL 1230
Score = 49.7 bits (117), Expect = 8e-06
Identities = 76/334 (22%), Positives = 136/334 (40%), Gaps = 57/334 (17%)
Query: 262 DQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEE---LAVANNRIITLQEEMERVKE 318
D + L L L+A D+L+K N L LA+A + T + R +
Sbjct: 332 DYHTALRRLESMLQPLAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEP 391
Query: 319 ESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMK 378
S D E Q L E + L+ E R VE+ + ++ ++
Sbjct: 392 IPS------------DAAQEMQELGEKLQALERE---RTKVEE-------VNRQQSAQLE 429
Query: 379 MLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAA 438
L K++ K+DA SL + + ++ L+ EL+ K Q +D +L RL+E + A
Sbjct: 430 QLVKELQLKEDARASLERLVKEMAPLQEELSGKGQEAD-------QLWRRLQE----LLA 478
Query: 439 TIKQLEQRLRQAERSRQSAELDNRLFKQDFGDKINSLQLEVEELTRQRNQLELELKQEKE 498
E+ L + R ++ + + L +Q+ LQ +E Q +Q +L+++K+
Sbjct: 479 HTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQF-LETQLAQVSQHVSDLEEQKK 537
Query: 499 RRLQNDRSI-------------PGR----GSQKSESKMDGKHKMQEENVKLKKPLEESHR 541
+ +Q+ + PG +K+E+ + +QE KP EE
Sbjct: 538 QLIQDKDHLSQQVGMLERLAGPPGPELPVAGEKNEALVPVNSSLQE---AWGKPEEEQRG 594
Query: 542 LQPHPMDEQDQLLLSEKPQLCQLCQEDGSLTKNV 575
LQ +D+ S++ +L Q +E +NV
Sbjct: 595 LQEAQLDDTKVQEGSQEEELRQANRELEKELQNV 628
Score = 48.5 bits (114), Expect = 2e-05
Identities = 74/345 (21%), Positives = 144/345 (41%), Gaps = 39/345 (11%)
Query: 256 QITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVA---NNRII----T 308
Q+ + + +EE + L ++L +V LE+ EL VA N ++ +
Sbjct: 521 QLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPELPVAGEKNEALVPVNSS 580
Query: 309 LQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQIS 368
LQE + +EE + E+ K ++ + L +A + L++E Q + + LE ++
Sbjct: 581 LQEAWGKPEEEQRGLQEAQLDDTKVQEGSQEEELRQANRELEKELQNVVGRNQLLEGKLQ 640
Query: 369 MRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGV-KQKSELNS 427
Q A++ E + Q +L SL + +R L ++++S L V K K + +
Sbjct: 641 ALQADYQALQQRESAI---QGSLASLEAEQASIR----HLGDQMEASLLAVRKAKEAMKA 693
Query: 428 RLEEKTNQMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFGDKINSLQL---------- 477
++ EK + + + +Q + E+ +Q AE +R + QL
Sbjct: 694 QMAEKEAILQSKEGECQQLREEVEQCQQLAEARHRELRALESQCQQQTQLIEVLTAEKGQ 753
Query: 478 ---------EVEELTRQ--RNQLELELKQEKERRLQNDRSIPGRGSQKSESKMDGKHKMQ 526
E EL Q +Q +LE+ Q + +RLQ + K + +D + K+Q
Sbjct: 754 QGVGPPTDNEARELAAQLALSQAQLEVHQGEVQRLQ---AQVVDLQAKMRAALDDQDKVQ 810
Query: 527 EENVKLKKPLEESHRLQPHPMDEQDQLLLSEKPQLCQLCQEDGSL 571
+ + L E L ++ + L + +L Q + +G+L
Sbjct: 811 SQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQCSEREGAL 855
Score = 47.4 bits (111), Expect = 4e-05
Identities = 68/342 (19%), Positives = 139/342 (40%), Gaps = 47/342 (13%)
Query: 272 RHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYI-------- 323
+ L A V +LQAK+ A K+ +L++A + + ++++KE++ +
Sbjct: 786 QRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQEL 845
Query: 324 ---------LESNRKGPKQDRTAEGQALSEARKHLK---EETQL-RLDVEKELEMQISMR 370
L+ R Q R E +AL E K EE QL +++++L +
Sbjct: 846 LQCSEREGALQEERADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQEQLHRANTDT 905
Query: 371 QEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLE 430
E+ + + L + ++AL Q+L D + L+ G++Q+ E
Sbjct: 906 AELGIQVCALTVEKERVEEALACAVQELQDAKEAASREREGLERQVAGLQQEKESLQEKL 965
Query: 431 EKTNQMAATIKQLEQRLRQAERSRQSAE------------------LDNRLFKQDFGDKI 472
+ A ++ L+ +L QAE+ QS + +D + ++ G++
Sbjct: 966 KAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLSAEIMDYQSRLKNAGEEC 1025
Query: 473 NSLQLEVEELTRQRNQLELELKQEKERRLQNDRSIPGRGSQKSESKMDGKHKMQEENVKL 532
SL+ ++EE RQ E +++ K + + + +E + K +E L
Sbjct: 1026 KSLRGQLEEQGRQLQAAEEAVEKLKATQADMGEKLSCTSNHLAECQAAMLRK-DKEGAAL 1084
Query: 533 KKPLEESHRLQPHPMDEQDQLLLSEKPQLCQLCQEDGSLTKN 574
++ LE + + E ++ + +LCQE + +N
Sbjct: 1085 REDLERTQK-------ELEKATTKIQEYYNKLCQEVTNRERN 1119
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 78.2 bits (191), Expect = 2e-14
Identities = 73/314 (23%), Positives = 151/314 (48%), Gaps = 32/314 (10%)
Query: 268 EELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRI----ITLQEEMERVKEESSYI 323
EE +HL A +Q + LE+ EE A ++ +T + ++++++EE +
Sbjct: 928 EERCQHLQAEKKKMQQNIQELEEQ----LEEEESARQKLQLEKVTTEAKLKKLEEEQIIL 983
Query: 324 LESNRKGPKQDRTAEGQALSEARKHLKEETQ--------------LRLDVEKELEMQISM 369
+ N K K+ + E + ++E +L EE + + D+E+ L +
Sbjct: 984 EDQNCKLAKEKKLLEDR-IAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQ 1042
Query: 370 RQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRL 429
RQE+E + LE D + D + L+ Q+ +L+ + +LQ++ V++++ +
Sbjct: 1043 RQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMA 1102
Query: 430 EEKTNQMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFGDKINSLQLEVEE-LTRQRNQ 488
+K ++ + I +L++ L SR AE K+D G+++ +L+ E+E+ L Q
Sbjct: 1103 LKKIRELESQISELQEDLESERASRNKAEKQ----KRDLGEELEALKTELEDTLDSTAAQ 1158
Query: 489 LELELKQEKE-RRLQNDRSIPGRGSQKSESKMDGKHKMQEENVKLKKPLEESHRLQPHPM 547
EL K+E+E L+ + + +M KH E +L + LE++ R++ + +
Sbjct: 1159 QELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVE--ELAEQLEQTKRVKAN-L 1215
Query: 548 DEQDQLLLSEKPQL 561
++ Q L +E+ +L
Sbjct: 1216 EKAKQTLENERGEL 1229
Score = 59.3 bits (142), Expect = 1e-08
Identities = 78/371 (21%), Positives = 155/371 (41%), Gaps = 71/371 (19%)
Query: 263 QKNYVEELNRHLNATVNNLQAKVDA-------LEKSNTKLTEELAVANNRI------ITL 309
QKN + R L + ++ LQ +++ EK L EEL +
Sbjct: 1098 QKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAA 1157
Query: 310 QEEMERVKEESSYILESNRKGPKQDRTAE--------GQALSEARKHLKEETQLRLDVEK 361
Q+E+ +E+ IL+ + + A+ QA+ E + L++ +++ ++EK
Sbjct: 1158 QQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEK 1217
Query: 362 ELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRA-------LKHELAFKLQS 414
+ + R E+ +K+L + + + + QL +L+ ++ ELA K+
Sbjct: 1218 AKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTK 1277
Query: 415 SDLGVKQKSELNSRLEEKTNQMAATIKQLEQRLRQA-----ERSRQSAELDNRLFKQDFG 469
+ + + L S+ + K++++ LE +L+ E +RQ L +L +
Sbjct: 1278 LQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKL--KQVE 1335
Query: 470 DKINSLQLEVEELTRQRNQLE-----------------------LELKQEKERRLQNDRS 506
D+ NS + ++EE ++ LE LE +E +R+LQ D
Sbjct: 1336 DEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKD-- 1393
Query: 507 IPGRGSQKSESKMDGKHKMQEENVKLKKPLEE-----SHRLQ-----PHPMDEQDQLLLS 556
+ G SQ+ E K+ K+++ +L++ L++ H+ Q + DQLL
Sbjct: 1394 LEGL-SQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAE 1452
Query: 557 EKPQLCQLCQE 567
EK + +E
Sbjct: 1453 EKTISAKYAEE 1463
Score = 55.5 bits (132), Expect = 1e-07
Identities = 79/405 (19%), Positives = 173/405 (42%), Gaps = 71/405 (17%)
Query: 228 DLDSQVGVIDFSMYLKDGNSSKGTEGDGQITAIL-DQKNYVEELNRH----------LNA 276
+LD+ G++ S D SSK T+ + + L D + ++E NR +
Sbjct: 1281 ELDNVTGLLSQS----DSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVED 1336
Query: 277 TVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEME------RVKEESSYILESNRKG 330
N+ + +++ E++ L +++A + ++ ++++ME EE L+ + +G
Sbjct: 1337 EKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEG 1396
Query: 331 PKQ---DRTAEGQALSEARKHLKEETQ-LRLDVEKELEMQISMRQEMELAMKML------ 380
Q ++ A L + + L++E L +D++ + + ++ ++ + ++L
Sbjct: 1397 LSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTI 1456
Query: 381 -----------EKDVCEKQDALVSLRQQLDDLRALKHELA-----FKLQSSDL------- 417
E + EK+ +SL + L++ K EL F+ + DL
Sbjct: 1457 SAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDV 1516
Query: 418 --GVKQKSELNSRLEEKTNQMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFGDKINSL 475
V + + LE++ +M +++LE L+ E ++ E++ + K F +
Sbjct: 1517 GKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGR 1576
Query: 476 QLEVEE----LTRQRNQLELELKQEKERRLQNDRSIPGRGS-----QKSESKMDGKHKMQ 526
+ EE L RQ ++E EL+ E+++R ++ R + E+ +D +K +
Sbjct: 1577 DEQSEEKKKQLVRQVREMEAELEDERKQR---SMAVAARKKLEMDLKDLEAHIDSANKNR 1633
Query: 527 EENVKLKKPLEESHRLQPHPMDEQDQLLLSEKPQLCQLCQEDGSL 571
+E +K + L+ + M E D S + L Q + + L
Sbjct: 1634 DEAIKQLRKLQAQMK---DCMRELDDTRASREEILAQAKENEKKL 1675
Score = 46.6 bits (109), Expect = 7e-05
Identities = 63/300 (21%), Positives = 129/300 (43%), Gaps = 50/300 (16%)
Query: 260 ILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEEL-----AVANN---------- 304
IL Q E+ + + A + LQ ++ A E++ + +E +AN+
Sbjct: 1664 ILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEE 1723
Query: 305 ------RIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLD 358
RI L+EE+E + + I + +K Q L+ R H ++ R
Sbjct: 1724 KRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTD-LNLERSHAQKNENARQQ 1782
Query: 359 VEKE-LEMQISMRQEMELAMKMLEK-DVCEKQDALVSLRQQLDDLRALKHELAFKLQSSD 416
+E++ E+++ + QEME +K K + + + L +QLD+ + +++ ++
Sbjct: 1783 LERQNKELKVKL-QEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTE 1841
Query: 417 -------LGVKQKSELNSRLEEKTNQMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFG 469
L V + + +++ ++ + +KQL+++L +AE Q A R
Sbjct: 1842 KKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRR------- 1894
Query: 470 DKINSLQLEVEELTRQRNQLELELKQEKERRLQNDRS--IPGRGSQK-----SESKMDGK 522
LQ E+E+ T + + E+ K + + D +P R ++K S+ ++DGK
Sbjct: 1895 ----KLQRELEDATETADAMNREVSSLKNKLRRGDLPFVVPRRMARKGAGDGSDEEVDGK 1950
Score = 45.1 bits (105), Expect = 2e-04
Identities = 55/236 (23%), Positives = 101/236 (42%), Gaps = 33/236 (13%)
Query: 307 ITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQ 366
++ QEE KEE + E Q +E R E Q +L EK L++Q
Sbjct: 840 VSRQEEEMMAKEEELV------------KVREKQLAAENRLTEMETLQSQLMAEK-LQLQ 886
Query: 367 ISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELN 426
++ E EL E ++ L + +L + H+L + V+++ E
Sbjct: 887 EQLQAETELC--------AEAEELRARLTAKKQELEEICHDLEAR-------VEEEEERC 931
Query: 427 SRLEEKTNQMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFGDKINSLQLEVEELTRQR 486
L+ + +M I++LE++L + E +RQ +L+ K K+ L+ E L Q
Sbjct: 932 QHLQAEKKKMQQNIQELEEQLEEEESARQKLQLE----KVTTEAKLKKLEEEQIILEDQN 987
Query: 487 NQLELELKQEKERRLQNDRSIPGRGSQ-KSESKMDGKHKMQEENVKLKKPLEESHR 541
+L E K ++R + ++ + KS +K+ KH+ +++ + EE R
Sbjct: 988 CKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQR 1043
Score = 44.3 bits (103), Expect = 3e-04
Identities = 57/265 (21%), Positives = 110/265 (41%), Gaps = 35/265 (13%)
Query: 262 DQKNYVEELNRHLNATVN-------NLQAKVDALEKSNTKLTEELAVANNRIITLQEEME 314
+ K +EEL L AT + NLQA E+ E+ +++ EME
Sbjct: 1536 EMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREME 1595
Query: 315 RVKEE----------SSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELE 364
E+ + LE + K + + + EA K L++ D +EL+
Sbjct: 1596 AELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELD 1655
Query: 365 MQISMRQEM-------ELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSD- 416
+ R+E+ E +K +E ++ + Q+ L + + + + ELA ++ +S
Sbjct: 1656 DTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSG 1715
Query: 417 ---LGVKQKSELNSR---LEEKTNQMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFGD 470
L +++K L +R LEE+ + + + RL++A D L +
Sbjct: 1716 KGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQK 1775
Query: 471 KINSLQLEVEELTRQRNQLELELKQ 495
N+ Q +L RQ +L+++L++
Sbjct: 1776 NENARQ----QLERQNKELKVKLQE 1796
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 75.5 bits (184), Expect = 1e-13
Identities = 109/448 (24%), Positives = 189/448 (42%), Gaps = 77/448 (17%)
Query: 168 RLALMQKKLSEYMKALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGE 227
R+A +Q+++ + KE L + YE +EE A++ + A ++ E
Sbjct: 844 RVAQLQRQIEDLKGDEAKAKETLKK-YEGEIRQLEE--ALVHARKEEKEAVSARRALENE 900
Query: 228 DLDSQVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKV-D 286
L++ G + + + S K E Q + KN +E HL T+ LQ ++ D
Sbjct: 901 -LEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMAD 959
Query: 287 ALEKSNTKLTE------ELAVANNRIITLQEEMERVKEESSYILESNR------------ 328
+E S T E E N R + EM+R +E + E +R
Sbjct: 960 IVEASRTSTLELQNQLDEYKEKNRRELA---EMQRQLKEKTLEAEKSRLTAMKMQDEMRL 1016
Query: 329 --KGPKQDRTAEGQALS----------------EARKHLKEETQLRLDVEKELEMQISMR 370
+ + + A+ +AL+ EA+ HLK++ R + K++E ++S +
Sbjct: 1017 MEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDD---RSRLVKQMEDKVS-Q 1072
Query: 371 QEMELAMK-----MLEKDVCEKQDALVSLRQQLDDLRALKHEL-----AFKLQSSDLG-- 418
EMEL + +L + + ++ + LR +L RA + +L + + Q+ DL
Sbjct: 1073 LEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSR 1132
Query: 419 -VKQKSELNSRLEEKTNQMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFGDKINSLQL 477
+ + S E QM A I +LE RL ER R + +L NR ++ + + +
Sbjct: 1133 IIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDD 1192
Query: 478 EVEELTRQRNQLELELK------QEKERRLQNDRSIPGRGSQKSESKMDGKHKMQEENVK 531
E LT Q++QL L LK +E E + S + ++ E +MD +Q +
Sbjct: 1193 EHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNS 1252
Query: 532 LKKPLEESHRLQPHP------MDEQDQL 553
+KK L RL+ P MD+ D L
Sbjct: 1253 MKKDL----RLKKLPSKVLDDMDDDDDL 1276
Score = 60.1 bits (144), Expect = 6e-09
Identities = 113/548 (20%), Positives = 220/548 (40%), Gaps = 67/548 (12%)
Query: 52 PDPEPTHEDPNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHC 111
P T P+ L + + + + K ++ + L G T D+D A ++ +V E
Sbjct: 528 PSASNTQATPDLLKGQQELTQQTNEETA-KQILYNYLKEGST-DNDDATKRKVNLVFEKI 585
Query: 112 LKHGLKAKKTFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLAL 171
+A + G N++ E V+ L+ + +++T V +L + + L +
Sbjct: 586 QTLKSRAAGSAQGNNQACNSTSE-VKDLLEQKSKLTIEVAEL--------QRQLQLEVKN 636
Query: 172 MQKKLSEYMKALINKKELLS---EFYEPNALMM----EEEGAIIAGLLVGLNVIDANFCM 224
Q E + N +EL S E E N+ + E EG + L V
Sbjct: 637 QQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQH 696
Query: 225 KGEDLDSQVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAK 284
+ E D Q + + L S+ E I +L K +++L + + +
Sbjct: 697 QTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDL-------LIAKEEQ 749
Query: 285 VDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQ----------- 333
D L K +LT + + +EM+++KE+ L++ R+ ++
Sbjct: 750 EDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASR 809
Query: 334 -DRTAEGQALSEAR-KHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDAL 391
+ + + QA +E R K L+EE + +ELE +++ Q + +E ++ A
Sbjct: 810 SNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQ------RQIEDLKGDEAKAK 863
Query: 392 VSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATI---KQLEQRLR 448
+L++ ++R L+ L + V + L + LE ++ T KQL ++L+
Sbjct: 864 ETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLK 923
Query: 449 Q-AERSRQSAELDNRLFKQDF--GDKINSLQLEVEELTRQRNQLELELKQEKERRLQNDR 505
+ +E+ Q L N + + + G I LQ E+ ++ LEL+
Sbjct: 924 EESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQ----------- 972
Query: 506 SIPGRGSQKSESKMDGKHKMQEENVKLKKPLEESHRLQPHPMDEQDQLLLSEKPQLCQLC 565
+Q E K + ++ E +LK+ E+ + + M QD++ L E+
Sbjct: 973 ------NQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQR 1026
Query: 566 QEDGSLTK 573
+D +LTK
Sbjct: 1027 AQDEALTK 1034
Score = 53.1 bits (126), Expect = 7e-07
Identities = 61/311 (19%), Positives = 131/311 (42%), Gaps = 32/311 (10%)
Query: 256 QITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMER 315
++ + ++ ++ + L V LQ +++ L+ K E L I L+E +
Sbjct: 823 RVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVH 882
Query: 316 VKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMEL 375
++E + + R A L A+ +L + TQ + + ++L+ + ++++
Sbjct: 883 ARKEEKEAVSARR--------ALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRR 934
Query: 376 AMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQ 435
+E + + L++++ D+ +LQ ++L+ E+ +
Sbjct: 935 LKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQ---------NQLDEYKEKNRRE 985
Query: 436 MAATIKQLEQRLRQAERSRQSA---ELDNRLFKQDFGDKINSLQLEVEELTRQRNQLE-- 490
+A +QL+++ +AE+SR +A + + RL +++ D Q +E +R LE
Sbjct: 986 LAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRD----YQRAQDEALTKRQLLEQT 1041
Query: 491 ---LELKQEKERRLQNDRSIPGRGSQKSESKMDGKHKMQEENVKLKKPLEESHRLQPHPM 547
LE + E + L++DRS R ++ E K+ EE L E M
Sbjct: 1042 LKDLEYELEAKSHLKDDRS---RLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQM 1098
Query: 548 DEQDQLLLSEK 558
++ LL E+
Sbjct: 1099 EQLRNELLQER 1109
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 73.9 bits (180), Expect = 4e-13
Identities = 79/296 (26%), Positives = 134/296 (45%), Gaps = 37/296 (12%)
Query: 280 NLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEG 339
NL K+ L KS A A + T++E+ ER KEE + E+ RK ++ +
Sbjct: 835 NLFFKIKPLLKS--------AEAEKEMATMKEDFERTKEELARS-EARRKELEEKMVSLL 885
Query: 340 QALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQ----------- 388
Q ++ + ++ ET+ +D E+ E I + +E +K L + + E++
Sbjct: 886 QEKNDLQLQVQSETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKR 945
Query: 389 ---DALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQ 445
D SL++ +DDL ++ + +++ VK SE + LEE +++ K L++
Sbjct: 946 NLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQE 1005
Query: 446 RLRQAERSRQSAELDNRLFKQDFGDKINSLQLEVEELTRQRNQLELELKQEKERRLQNDR 505
+Q Q E DK+N L +L +Q + LE L+QEK+ R +R
Sbjct: 1006 AHQQTLDDLQVEE-----------DKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLER 1054
Query: 506 S---IPGRGSQKSESKMDGKHKMQEENVKLKKPLEESHRLQPHPMDEQDQLLLSEK 558
+ + G ES MD ++ Q+ KLKK E +LQ DEQ L +K
Sbjct: 1055 AKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQK 1110
Score = 67.4 bits (163), Expect = 4e-11
Identities = 62/314 (19%), Positives = 135/314 (42%), Gaps = 19/314 (6%)
Query: 254 DGQITAILDQKNYVEELNRHLNATVNNLQAK-------VDALEKSNTKLTEELAVANNRI 306
+ ++ + ++ EE+N L A NL+ K +D LE + TK+ +E N++
Sbjct: 920 EAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKV 979
Query: 307 ITLQEEMERVKEESSYI------LESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVE 360
L EEM ++E S + L+ + D E ++ K + Q D+E
Sbjct: 980 KNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLE 1039
Query: 361 KELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVK 420
LE + +R ++E A + LE D+ Q++++ L + + F+L +
Sbjct: 1040 GSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKID 1099
Query: 421 QKSELNSRLEEKTNQMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFGDKINSLQLEVE 480
+ + + ++K ++ A I++LE+ + R E + D ++ + +E
Sbjct: 1100 DEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQ----RSDLARELEEISERLE 1155
Query: 481 ELTRQRNQLELELKQEKERRLQNDRSIPGRGSQKSESKMDGKHKMQEENV-KLKKPLEES 539
E + ++E+ +++E Q R + + E+ K Q ++V +L + ++
Sbjct: 1156 EAS-GATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNL 1214
Query: 540 HRLQPHPMDEQDQL 553
R++ E+ +L
Sbjct: 1215 QRVKQKLEKEKSEL 1228
Score = 56.2 bits (134), Expect = 9e-08
Identities = 79/409 (19%), Positives = 177/409 (43%), Gaps = 54/409 (13%)
Query: 164 RAWLRLALMQKKLSEYMKALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLN----VID 219
R+ A + KK + K L K+ L E +E ++ L N V+D
Sbjct: 1438 RSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVD 1497
Query: 220 ANFCMKGEDLDSQVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVN 279
++ E+ + Q + D + + + + K + + +++Q+ +L L
Sbjct: 1498 QLETLRRENKNLQEEISDLTEQIAE--TGKNLQEAEKTKKLVEQEK--SDLQVALEEVEG 1553
Query: 280 NLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEG 339
+L+ + + + +L++ + + ++I EE+E++K S R AE
Sbjct: 1554 SLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQ-------------RAAEA 1600
Query: 340 -QALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQL 398
Q++ +A + + L ++K++E ++ EME+ + + + E Q L +++ QL
Sbjct: 1601 LQSVLDAEIRSRNDA---LRLKKKMEGDLN---EMEIQLGHSNRQMAETQKHLRTVQGQL 1654
Query: 399 DDLRALKHELAFKLQSSDLGVKQKSELNSRL---EEKTNQMAATIKQLEQRLRQAERSRQ 455
D + D ++ +L +L E + + +++++ L Q ER+R+
Sbjct: 1655 KDSQL----------HLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRR 1704
Query: 456 SAELDNRLFKQDFGDKINSLQLEVEELTRQRNQLELELKQ---EKERRLQNDRSIPGRGS 512
+E + D D++ L + L + +LE ++ Q E E +Q R+ +
Sbjct: 1705 LSEQE----LLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAK 1760
Query: 513 QK-SESKMDGKHKMQEENV-----KLKKPLEESHRLQPHPMDEQDQLLL 555
+ +++ M + +E++ ++KK LE++ + H +DE +QL L
Sbjct: 1761 KAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLAL 1809
Score = 55.8 bits (133), Expect = 1e-07
Identities = 79/354 (22%), Positives = 166/354 (46%), Gaps = 49/354 (13%)
Query: 224 MKGEDLDSQVGVIDFSMYLKDGNSSKGTEGDGQITAILDQ-KNYVEELNRHLNATVNNLQ 282
M+ L +Q G + + K+ S+ T+ +T L++ K +EE + NA + LQ
Sbjct: 1279 MQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQ 1338
Query: 283 ------------------AKVD---ALEKSNTKLTEELAVANNRIITLQEEMERVKEESS 321
AK + AL K+N+++ + I EE+E K++ +
Sbjct: 1339 SSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLA 1398
Query: 322 YILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLE 381
L+ + + ++ +L + ++ L+ E + D+ ++LE + ++ + +
Sbjct: 1399 QRLQEAEENT-ETANSKCASLEKTKQRLQGEVE---DLMRDLERSHTACATLDKKQRNFD 1454
Query: 382 KDVCEKQDALVSLRQQLD----DLRALKHELAFKLQSSDLGVKQKSEL----NSRLEEKT 433
K + E + L + +L+ + R+L EL FK++++ V + E N L+E+
Sbjct: 1455 KVLAEWKQKLDESQAELEAAQKESRSLSTEL-FKMRNAYEEVVDQLETLRRENKNLQEEI 1513
Query: 434 NQMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFGDKINSLQ--LEVEELTRQRNQLEL 491
+ + I + + L++AE++++ E + K D + ++ LE EE R QLEL
Sbjct: 1514 SDLTEQIAETGKNLQEAEKTKKLVEQE----KSDLQVALEEVEGSLEHEESKILRVQLEL 1569
Query: 492 -ELKQEKERR-LQNDRSIP--GRGSQKS----ESKMDGKHKMQEENVKLKKPLE 537
++K E +R+ ++ D I R SQ++ +S +D + + + + ++LKK +E
Sbjct: 1570 SQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKME 1623
Score = 55.1 bits (131), Expect = 2e-07
Identities = 79/342 (23%), Positives = 149/342 (43%), Gaps = 51/342 (14%)
Query: 229 LDSQVGVIDFSMYLKDGNSSKGTEGD-GQITAILDQKN-YVEELNRHLNATVNNL---QA 283
LD+++ + ++ LK K EGD ++ L N + E +HL L Q
Sbjct: 1605 LDAEIRSRNDALRLK-----KKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQL 1659
Query: 284 KVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQ-----DRT-- 336
+D +SN L E+LA+ R L EE+E +K + R ++ DR
Sbjct: 1660 HLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQL 1719
Query: 337 --AEGQALSEARKHLKEE-TQLRLDVEKELEMQISMRQEMELAM---KMLEKDVCEKQDA 390
++ +L +K L+ + Q + +VE ++ + ++ + A+ M+ +++ ++QD
Sbjct: 1720 LHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDT 1779
Query: 391 LVSLRQQLDDLRALKHELAFKLQSSDL-----GVKQKSELNSRLEEKTNQM-------AA 438
L + +L +L +L ++ G KQ +L +R+ E N++ A
Sbjct: 1780 SAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAE 1839
Query: 439 TIKQLEQRLRQAERSRQSAELD--NRLFKQDFGDKINSLQLEVEELTRQRNQLELELKQE 496
+K + R+ + AE D N L QD DK LQ +V+ RQ + E + +
Sbjct: 1840 ALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDK---LQAKVKSYKRQAEEAEEQANTQ 1896
Query: 497 --KERRLQNDRSIPGRGSQKSESKMD---------GKHKMQE 527
+ RR+Q++ + +ES+++ G KM+E
Sbjct: 1897 LSRCRRVQHELEEAAERADIAESQVNKLRAKSRDVGSQKMEE 1938
Score = 51.6 bits (122), Expect = 2e-06
Identities = 103/472 (21%), Positives = 186/472 (39%), Gaps = 116/472 (24%)
Query: 174 KKLSEYMKALINKKELLSEFYEPNALMMEEEGAIIAGLLV------GLNVIDANFCMKGE 227
K LSE M AL +E +S+ + + E + L V GL I+A + +
Sbjct: 980 KNLSEEMTAL---EENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTD 1036
Query: 228 DLDSQVGVIDFSMYLKDG--NSSKGTEGDGQIT--AILDQKN---YVEELNRHLNATVNN 280
DL+ G ++ L+ + + EGD +++ +I+D +N +EE + ++
Sbjct: 1037 DLE---GSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQ 1093
Query: 281 LQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQ 340
LQAK+D + + + +++ RI L+EE+E + + L + + + D E +
Sbjct: 1094 LQAKIDDEQVHSLQFQKKIKELQARIEELEEEIE-----AEHTLRAKIEKQRSDLARELE 1148
Query: 341 ALSEARKHLKEETQLRLDVEKELEMQIS-MRQEMELAMKMLEKDVC----EKQDALVSLR 395
+SE + T ++++ K+ E + MR+++E A E ++ D++ L
Sbjct: 1149 EISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELG 1208
Query: 396 QQLDDLRAL-------KHELAFKL--------------------------QSSDLGVK-- 420
+Q+D+L+ + K EL ++ Q S++ K
Sbjct: 1209 EQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDE 1268
Query: 421 ------------------QKSELNSRLEEK-------TNQMAATIKQLEQRLRQAERSR- 454
Q EL+ R+EEK T A +QLE+ RQ E
Sbjct: 1269 QQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETK 1328
Query: 455 ---------QSAELDNRLFKQDFGD-------------KINS----LQLEVEELTRQRNQ 488
QS+ D L ++ + + K NS + + E QR +
Sbjct: 1329 AKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTE 1388
Query: 489 LELELKQEKERRLQNDRSIPGRGSQKSESKMDGKHKMQEENVKLKKPLEESH 540
E K++ +RLQ + K S K ++Q E L + LE SH
Sbjct: 1389 ELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSH 1440
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 73.9 bits (180), Expect = 4e-13
Identities = 71/285 (24%), Positives = 130/285 (45%), Gaps = 29/285 (10%)
Query: 267 VEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILES 326
+E+ + L N LQ ++ A T+L E R+ ++E+E + E LE
Sbjct: 878 LEQKHSQLTEEKNLLQEQLQA----ETELYAEAEEMRVRLAAKKQELEEILHEMEARLEE 933
Query: 327 NRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCE 386
++DR GQ L RK + ++ LD+E++LE + + RQ+++L E + +
Sbjct: 934 -----EEDR---GQQLQAERKKMAQQM---LDLEEQLEEEEAARQKLQLEKVTAEAKIKK 982
Query: 387 KQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQR 446
+D ++ + Q + L + L ++ + ++ E L + N+ + I +LE R
Sbjct: 983 LEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR 1042
Query: 447 LRQAERSRQSAELDNRLFK---QDFGDKINSLQLEVEELTRQRNQLELELK--------- 494
L++ E+SRQ E R + DF ++I LQ ++ EL Q + E EL+
Sbjct: 1043 LKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDE 1102
Query: 495 -QEKERRLQNDRSIPGRGSQKSESKMDGKHKMQEENVKLKKPLEE 538
+K L+ R + G S E +D + + + K K+ L E
Sbjct: 1103 IAQKNNALKKIRELEGHISDLQED-LDSERAARNKAEKQKRDLGE 1146
Score = 63.2 bits (152), Expect = 7e-10
Identities = 84/420 (20%), Positives = 174/420 (41%), Gaps = 61/420 (14%)
Query: 170 ALMQKKLSEYMKALINKKELLSEF------YEPNALMMEEEGAIIAGLLVGLNVIDANFC 223
A +Q+ ++ +A+ E L +F + N +E+E A +AG L L
Sbjct: 1192 AQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVE 1251
Query: 224 MKGEDLDSQVGVIDFSMYLKDGNSSKGTEGD------GQITAILDQKNYVEELNRHLNAT 277
K + L++QV + DG ++ D ++ ++ N E L
Sbjct: 1252 HKKKKLEAQVQ--ELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKD 1309
Query: 278 VNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQDRTA 337
V +L +++ ++ + T + + ++ L+EE ++++ +E+ + + T
Sbjct: 1310 VASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1369
Query: 338 EGQALSEARKHLK---------EETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQ 388
Q LS+++K L+ EE + R +KE+E +E A LEK Q
Sbjct: 1370 NIQ-LSDSKKKLQDFASTVEALEEGKKRF--QKEIENLTQQYEEKAAAYDKLEKTKNRLQ 1426
Query: 389 DALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQR-- 446
L L LD+ R L L K + D + ++ ++S+ ++ ++ A ++ E +
Sbjct: 1427 QELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL 1486
Query: 447 -----LRQAERSRQSAELDNRLFKQDFGDKINS-----------------LQLEVEELTR 484
L +A +++ E N++ K + D ++S L+ ++EE+
Sbjct: 1487 SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKT 1546
Query: 485 QRNQLELELKQEKERRL-----------QNDRSIPGRGSQKSESKMDGKHKMQEENVKLK 533
Q +LE EL+ ++ +L Q +R + R Q E + + ++ E +L+
Sbjct: 1547 QLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELE 1606
Score = 62.4 bits (150), Expect = 1e-09
Identities = 76/333 (22%), Positives = 142/333 (42%), Gaps = 80/333 (24%)
Query: 261 LDQKNYVEELNRHLNATVNNLQAKVD-------ALEKSNTKLTEELAVANNRIITLQEEM 313
L+ K +E N+ L A + +L + D LEKS L ++ ++ L++E+
Sbjct: 1496 LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDEL 1555
Query: 314 ERVKEESSYILESNRKGPK----QDRTAEGQALSEARKHLKE-----ETQLR-------- 356
+ E++ LE N + K +D A + E R+ L+ ET+L
Sbjct: 1556 QAT-EDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRAL 1614
Query: 357 ------------LDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRAL 404
D+E + + I R+E A+K L K + +D +++L+D RA
Sbjct: 1615 AAAAKKKLEGDLKDLELQADSAIKGREE---AIKQLRKLQAQMKD----FQRELEDARAS 1667
Query: 405 KHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQRLRQAERSRQSAELDNRLF 464
+ E+ + + E+K + A + QL++ L AER+R+ A+L+
Sbjct: 1668 RDEIFATAKEN--------------EKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL 1713
Query: 465 KQDFGDKI---NSLQLEVEELTRQRNQLELELKQE----------------KERRLQNDR 505
++ + N+LQ E L + QLE EL++E + +L N+
Sbjct: 1714 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1773
Query: 506 SIPGRGSQKSESKMDGKHKMQEENVKLKKPLEE 538
+ +QK+ES + +++ +N +L+ L E
Sbjct: 1774 ATERSTAQKNES---ARQQLERQNKELRSKLHE 1803
Score = 55.8 bits (133), Expect = 1e-07
Identities = 73/322 (22%), Positives = 136/322 (42%), Gaps = 50/322 (15%)
Query: 252 EGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANN---RIIT 308
EGD D + +L + L K + L+ + +L +E+A NN +I
Sbjct: 1061 EGDAS-----DFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRE 1115
Query: 309 LQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLD-VEKELEMQI 367
L+ + ++E+ + K KQ R L E + LK E + LD + E++
Sbjct: 1116 LEGHISDLQEDLDSERAARNKAEKQKRD-----LGEELEALKTELEDTLDSTATQQELRA 1170
Query: 368 SMRQEMELAMKMLEKDVCEKQ-----------DALVSLRQQLDDLRALKHEL-----AFK 411
QE+ + K L+++ + A+ L +QL+ + K L +
Sbjct: 1171 KREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE 1230
Query: 412 LQSSDLG--VKQKSELNSRLEEKTNQMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFG 469
+++DL ++ + +E K ++ A +++L+ + ER+R AEL+
Sbjct: 1231 KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERAR--AELN--------- 1279
Query: 470 DKINSLQLEVEELTRQRNQLELELKQEKERRLQND-RSIPGRGSQKSESKMDGKHKMQEE 528
DK++ LQ EVE +T N+ E K +L D S+ + E + +
Sbjct: 1280 DKVHKLQNEVESVTGMLNEAE-----GKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV 1334
Query: 529 NVKLKKPLEESHRLQPHPMDEQ 550
+ KL++ EE + LQ +DE+
Sbjct: 1335 STKLRQLEEERNSLQDQ-LDEE 1355
Score = 54.7 bits (130), Expect = 3e-07
Identities = 53/213 (24%), Positives = 100/213 (46%), Gaps = 18/213 (8%)
Query: 338 EGQALSEARKHLKEETQLRLDVEKELEMQIS-MRQEMELAMKMLEKDV---CEKQDALVS 393
E QA + + KE Q + KELE + S + +E L + L+ + E ++ V
Sbjct: 853 EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR 912
Query: 394 LRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQRLRQAERS 453
L + +L + HE+ +L+ ++ + +L+ + +MA + LE++L + E +
Sbjct: 913 LAAKKQELEEILHEMEARLE-------EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 965
Query: 454 RQSAELDNRLFKQDFGDKINSLQLEVEELTRQRNQLELELKQEKERRLQNDRSIPGRGSQ 513
RQ +L+ K KI L+ E+ + Q N+L E K +ER ++ +
Sbjct: 966 RQKLQLE----KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1021
Query: 514 -KSESKMDGKHK--MQEENVKLKKPLEESHRLQ 543
K+ +K+ KH+ + E V+LKK + L+
Sbjct: 1022 AKNLTKLKNKHESMISELEVRLKKEEKSRQELE 1054
Score = 52.8 bits (125), Expect = 1e-06
Identities = 69/308 (22%), Positives = 129/308 (41%), Gaps = 42/308 (13%)
Query: 232 QVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKS 291
Q + DF L+D +S+ +I A + E+ + L A + LQ + A E++
Sbjct: 1651 QAQMKDFQRELEDARASRD-----EIFATAKEN---EKKAKSLEADLMQLQEDLAAAERA 1702
Query: 292 NTK-------LTEELAVANN--------------RIITLQEEMERVKEESSYILESNRKG 330
+ L EELA + + RI L+EE+E + + + RK
Sbjct: 1703 RKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKA 1762
Query: 331 PKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDA 390
+Q + +E K E+ R +E++ + S EME A+K K +A
Sbjct: 1763 TQQAEQLSNELATERSTAQKNESA-RQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEA 1821
Query: 391 LVS-LRQQLDDLRALKHELAFKLQSSD-------LGVKQKSELNSRLEEKTNQMAATIKQ 442
++ L +Q++ K L+ D L V+ + ++ + +E+ + A +KQ
Sbjct: 1822 KIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQ 1881
Query: 443 LEQRLRQAERSRQSAELDNRLFKQDFGDKINSLQLEVEELTRQRNQLELELKQEKERRLQ 502
L+++L +AE Q + R +++ + S E + R+ N L+ +L++ E
Sbjct: 1882 LKRQLEEAEEESQRINANRRKLQRELDEATES----NEAMGREVNALKSKLRRGNETSFV 1937
Query: 503 NDRSIPGR 510
R GR
Sbjct: 1938 PSRRSGGR 1945
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 73.9 bits (180), Expect = 4e-13
Identities = 71/285 (24%), Positives = 130/285 (45%), Gaps = 29/285 (10%)
Query: 267 VEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILES 326
+E+ + L N LQ ++ A T+L E R+ ++E+E + E LE
Sbjct: 885 LEQKHSQLTEEKNLLQEQLQA----ETELYAEAEEMRVRLAAKKQELEEILHEMEARLEE 940
Query: 327 NRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCE 386
++DR GQ L RK + ++ LD+E++LE + + RQ+++L E + +
Sbjct: 941 -----EEDR---GQQLQAERKKMAQQM---LDLEEQLEEEEAARQKLQLEKVTAEAKIKK 989
Query: 387 KQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQR 446
+D ++ + Q + L + L ++ + ++ E L + N+ + I +LE R
Sbjct: 990 LEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR 1049
Query: 447 LRQAERSRQSAELDNRLFK---QDFGDKINSLQLEVEELTRQRNQLELELK--------- 494
L++ E+SRQ E R + DF ++I LQ ++ EL Q + E EL+
Sbjct: 1050 LKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDE 1109
Query: 495 -QEKERRLQNDRSIPGRGSQKSESKMDGKHKMQEENVKLKKPLEE 538
+K L+ R + G S E +D + + + K K+ L E
Sbjct: 1110 IAQKNNALKKIRELEGHISDLQED-LDSERAARNKAEKQKRDLGE 1153
Score = 63.2 bits (152), Expect = 7e-10
Identities = 84/420 (20%), Positives = 174/420 (41%), Gaps = 61/420 (14%)
Query: 170 ALMQKKLSEYMKALINKKELLSEF------YEPNALMMEEEGAIIAGLLVGLNVIDANFC 223
A +Q+ ++ +A+ E L +F + N +E+E A +AG L L
Sbjct: 1199 AQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVE 1258
Query: 224 MKGEDLDSQVGVIDFSMYLKDGNSSKGTEGD------GQITAILDQKNYVEELNRHLNAT 277
K + L++QV + DG ++ D ++ ++ N E L
Sbjct: 1259 HKKKKLEAQVQ--ELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKD 1316
Query: 278 VNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQDRTA 337
V +L +++ ++ + T + + ++ L+EE ++++ +E+ + + T
Sbjct: 1317 VASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1376
Query: 338 EGQALSEARKHLK---------EETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQ 388
Q LS+++K L+ EE + R +KE+E +E A LEK Q
Sbjct: 1377 NIQ-LSDSKKKLQDFASTVEALEEGKKRF--QKEIENLTQQYEEKAAAYDKLEKTKNRLQ 1433
Query: 389 DALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQR-- 446
L L LD+ R L L K + D + ++ ++S+ ++ ++ A ++ E +
Sbjct: 1434 QELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL 1493
Query: 447 -----LRQAERSRQSAELDNRLFKQDFGDKINS-----------------LQLEVEELTR 484
L +A +++ E N++ K + D ++S L+ ++EE+
Sbjct: 1494 SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKT 1553
Query: 485 QRNQLELELKQEKERRL-----------QNDRSIPGRGSQKSESKMDGKHKMQEENVKLK 533
Q +LE EL+ ++ +L Q +R + R Q E + + ++ E +L+
Sbjct: 1554 QLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELE 1613
Score = 62.4 bits (150), Expect = 1e-09
Identities = 76/333 (22%), Positives = 142/333 (42%), Gaps = 80/333 (24%)
Query: 261 LDQKNYVEELNRHLNATVNNLQAKVD-------ALEKSNTKLTEELAVANNRIITLQEEM 313
L+ K +E N+ L A + +L + D LEKS L ++ ++ L++E+
Sbjct: 1503 LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDEL 1562
Query: 314 ERVKEESSYILESNRKGPK----QDRTAEGQALSEARKHLKE-----ETQLR-------- 356
+ E++ LE N + K +D A + E R+ L+ ET+L
Sbjct: 1563 QAT-EDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRAL 1621
Query: 357 ------------LDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRAL 404
D+E + + I R+E A+K L K + +D +++L+D RA
Sbjct: 1622 AAAAKKKLEGDLKDLELQADSAIKGREE---AIKQLRKLQAQMKD----FQRELEDARAS 1674
Query: 405 KHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQRLRQAERSRQSAELDNRLF 464
+ E+ + + E+K + A + QL++ L AER+R+ A+L+
Sbjct: 1675 RDEIFATAKEN--------------EKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL 1720
Query: 465 KQDFGDKI---NSLQLEVEELTRQRNQLELELKQE----------------KERRLQNDR 505
++ + N+LQ E L + QLE EL++E + +L N+
Sbjct: 1721 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1780
Query: 506 SIPGRGSQKSESKMDGKHKMQEENVKLKKPLEE 538
+ +QK+ES + +++ +N +L+ L E
Sbjct: 1781 ATERSTAQKNES---ARQQLERQNKELRSKLHE 1810
Score = 55.8 bits (133), Expect = 1e-07
Identities = 73/322 (22%), Positives = 136/322 (42%), Gaps = 50/322 (15%)
Query: 252 EGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANN---RIIT 308
EGD D + +L + L K + L+ + +L +E+A NN +I
Sbjct: 1068 EGDAS-----DFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRE 1122
Query: 309 LQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLD-VEKELEMQI 367
L+ + ++E+ + K KQ R L E + LK E + LD + E++
Sbjct: 1123 LEGHISDLQEDLDSERAARNKAEKQKRD-----LGEELEALKTELEDTLDSTATQQELRA 1177
Query: 368 SMRQEMELAMKMLEKDVCEKQ-----------DALVSLRQQLDDLRALKHEL-----AFK 411
QE+ + K L+++ + A+ L +QL+ + K L +
Sbjct: 1178 KREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE 1237
Query: 412 LQSSDLG--VKQKSELNSRLEEKTNQMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFG 469
+++DL ++ + +E K ++ A +++L+ + ER+R AEL+
Sbjct: 1238 KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERAR--AELN--------- 1286
Query: 470 DKINSLQLEVEELTRQRNQLELELKQEKERRLQND-RSIPGRGSQKSESKMDGKHKMQEE 528
DK++ LQ EVE +T N+ E K +L D S+ + E + +
Sbjct: 1287 DKVHKLQNEVESVTGMLNEAE-----GKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV 1341
Query: 529 NVKLKKPLEESHRLQPHPMDEQ 550
+ KL++ EE + LQ +DE+
Sbjct: 1342 STKLRQLEEERNSLQDQ-LDEE 1362
Score = 54.7 bits (130), Expect = 3e-07
Identities = 53/213 (24%), Positives = 100/213 (46%), Gaps = 18/213 (8%)
Query: 338 EGQALSEARKHLKEETQLRLDVEKELEMQIS-MRQEMELAMKMLEKDV---CEKQDALVS 393
E QA + + KE Q + KELE + S + +E L + L+ + E ++ V
Sbjct: 860 EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR 919
Query: 394 LRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQRLRQAERS 453
L + +L + HE+ +L+ ++ + +L+ + +MA + LE++L + E +
Sbjct: 920 LAAKKQELEEILHEMEARLE-------EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 972
Query: 454 RQSAELDNRLFKQDFGDKINSLQLEVEELTRQRNQLELELKQEKERRLQNDRSIPGRGSQ 513
RQ +L+ K KI L+ E+ + Q N+L E K +ER ++ +
Sbjct: 973 RQKLQLE----KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1028
Query: 514 -KSESKMDGKHK--MQEENVKLKKPLEESHRLQ 543
K+ +K+ KH+ + E V+LKK + L+
Sbjct: 1029 AKNLTKLKNKHESMISELEVRLKKEEKSRQELE 1061
Score = 52.8 bits (125), Expect = 1e-06
Identities = 69/308 (22%), Positives = 129/308 (41%), Gaps = 42/308 (13%)
Query: 232 QVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKS 291
Q + DF L+D +S+ +I A + E+ + L A + LQ + A E++
Sbjct: 1658 QAQMKDFQRELEDARASRD-----EIFATAKEN---EKKAKSLEADLMQLQEDLAAAERA 1709
Query: 292 NTK-------LTEELAVANN--------------RIITLQEEMERVKEESSYILESNRKG 330
+ L EELA + + RI L+EE+E + + + RK
Sbjct: 1710 RKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKA 1769
Query: 331 PKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDA 390
+Q + +E K E+ R +E++ + S EME A+K K +A
Sbjct: 1770 TQQAEQLSNELATERSTAQKNESA-RQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEA 1828
Query: 391 LVS-LRQQLDDLRALKHELAFKLQSSD-------LGVKQKSELNSRLEEKTNQMAATIKQ 442
++ L +Q++ K L+ D L V+ + ++ + +E+ + A +KQ
Sbjct: 1829 KIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQ 1888
Query: 443 LEQRLRQAERSRQSAELDNRLFKQDFGDKINSLQLEVEELTRQRNQLELELKQEKERRLQ 502
L+++L +AE Q + R +++ + S E + R+ N L+ +L++ E
Sbjct: 1889 LKRQLEEAEEESQRINANRRKLQRELDEATES----NEAMGREVNALKSKLRRGNETSFV 1944
Query: 503 NDRSIPGR 510
R GR
Sbjct: 1945 PSRRSGGR 1952
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 73.9 bits (180), Expect = 4e-13
Identities = 71/285 (24%), Positives = 130/285 (45%), Gaps = 29/285 (10%)
Query: 267 VEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILES 326
+E+ + L N LQ ++ A T+L E R+ ++E+E + E LE
Sbjct: 885 LEQKHSQLTEEKNLLQEQLQA----ETELYAEAEEMRVRLAAKKQELEEILHEMEARLEE 940
Query: 327 NRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCE 386
++DR GQ L RK + ++ LD+E++LE + + RQ+++L E + +
Sbjct: 941 -----EEDR---GQQLQAERKKMAQQM---LDLEEQLEEEEAARQKLQLEKVTAEAKIKK 989
Query: 387 KQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQR 446
+D ++ + Q + L + L ++ + ++ E L + N+ + I +LE R
Sbjct: 990 LEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR 1049
Query: 447 LRQAERSRQSAELDNRLFK---QDFGDKINSLQLEVEELTRQRNQLELELK--------- 494
L++ E+SRQ E R + DF ++I LQ ++ EL Q + E EL+
Sbjct: 1050 LKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDE 1109
Query: 495 -QEKERRLQNDRSIPGRGSQKSESKMDGKHKMQEENVKLKKPLEE 538
+K L+ R + G S E +D + + + K K+ L E
Sbjct: 1110 IAQKNNALKKIRELEGHISDLQED-LDSERAARNKAEKQKRDLGE 1153
Score = 63.2 bits (152), Expect = 7e-10
Identities = 84/420 (20%), Positives = 174/420 (41%), Gaps = 61/420 (14%)
Query: 170 ALMQKKLSEYMKALINKKELLSEF------YEPNALMMEEEGAIIAGLLVGLNVIDANFC 223
A +Q+ ++ +A+ E L +F + N +E+E A +AG L L
Sbjct: 1199 AQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVE 1258
Query: 224 MKGEDLDSQVGVIDFSMYLKDGNSSKGTEGD------GQITAILDQKNYVEELNRHLNAT 277
K + L++QV + DG ++ D ++ ++ N E L
Sbjct: 1259 HKKKKLEAQVQ--ELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKD 1316
Query: 278 VNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQDRTA 337
V +L +++ ++ + T + + ++ L+EE ++++ +E+ + + T
Sbjct: 1317 VASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1376
Query: 338 EGQALSEARKHLK---------EETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQ 388
Q LS+++K L+ EE + R +KE+E +E A LEK Q
Sbjct: 1377 NIQ-LSDSKKKLQDFASTVEALEEGKKRF--QKEIENLTQQYEEKAAAYDKLEKTKNRLQ 1433
Query: 389 DALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQR-- 446
L L LD+ R L L K + D + ++ ++S+ ++ ++ A ++ E +
Sbjct: 1434 QELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL 1493
Query: 447 -----LRQAERSRQSAELDNRLFKQDFGDKINS-----------------LQLEVEELTR 484
L +A +++ E N++ K + D ++S L+ ++EE+
Sbjct: 1494 SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKT 1553
Query: 485 QRNQLELELKQEKERRL-----------QNDRSIPGRGSQKSESKMDGKHKMQEENVKLK 533
Q +LE EL+ ++ +L Q +R + R Q E + + ++ E +L+
Sbjct: 1554 QLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELE 1613
Score = 62.4 bits (150), Expect = 1e-09
Identities = 76/333 (22%), Positives = 142/333 (42%), Gaps = 80/333 (24%)
Query: 261 LDQKNYVEELNRHLNATVNNLQAKVD-------ALEKSNTKLTEELAVANNRIITLQEEM 313
L+ K +E N+ L A + +L + D LEKS L ++ ++ L++E+
Sbjct: 1503 LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDEL 1562
Query: 314 ERVKEESSYILESNRKGPK----QDRTAEGQALSEARKHLKE-----ETQLR-------- 356
+ E++ LE N + K +D A + E R+ L+ ET+L
Sbjct: 1563 QAT-EDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRAL 1621
Query: 357 ------------LDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRAL 404
D+E + + I R+E A+K L K + +D +++L+D RA
Sbjct: 1622 AAAAKKKLEGDLKDLELQADSAIKGREE---AIKQLRKLQAQMKD----FQRELEDARAS 1674
Query: 405 KHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQRLRQAERSRQSAELDNRLF 464
+ E+ + + E+K + A + QL++ L AER+R+ A+L+
Sbjct: 1675 RDEIFATAKEN--------------EKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL 1720
Query: 465 KQDFGDKI---NSLQLEVEELTRQRNQLELELKQE----------------KERRLQNDR 505
++ + N+LQ E L + QLE EL++E + +L N+
Sbjct: 1721 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1780
Query: 506 SIPGRGSQKSESKMDGKHKMQEENVKLKKPLEE 538
+ +QK+ES + +++ +N +L+ L E
Sbjct: 1781 ATERSTAQKNES---ARQQLERQNKELRSKLHE 1810
Score = 55.8 bits (133), Expect = 1e-07
Identities = 73/322 (22%), Positives = 136/322 (42%), Gaps = 50/322 (15%)
Query: 252 EGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANN---RIIT 308
EGD D + +L + L K + L+ + +L +E+A NN +I
Sbjct: 1068 EGDAS-----DFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRE 1122
Query: 309 LQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLD-VEKELEMQI 367
L+ + ++E+ + K KQ R L E + LK E + LD + E++
Sbjct: 1123 LEGHISDLQEDLDSERAARNKAEKQKRD-----LGEELEALKTELEDTLDSTATQQELRA 1177
Query: 368 SMRQEMELAMKMLEKDVCEKQ-----------DALVSLRQQLDDLRALKHEL-----AFK 411
QE+ + K L+++ + A+ L +QL+ + K L +
Sbjct: 1178 KREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE 1237
Query: 412 LQSSDLG--VKQKSELNSRLEEKTNQMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFG 469
+++DL ++ + +E K ++ A +++L+ + ER+R AEL+
Sbjct: 1238 KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERAR--AELN--------- 1286
Query: 470 DKINSLQLEVEELTRQRNQLELELKQEKERRLQND-RSIPGRGSQKSESKMDGKHKMQEE 528
DK++ LQ EVE +T N+ E K +L D S+ + E + +
Sbjct: 1287 DKVHKLQNEVESVTGMLNEAE-----GKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV 1341
Query: 529 NVKLKKPLEESHRLQPHPMDEQ 550
+ KL++ EE + LQ +DE+
Sbjct: 1342 STKLRQLEEERNSLQDQ-LDEE 1362
Score = 54.7 bits (130), Expect = 3e-07
Identities = 53/213 (24%), Positives = 100/213 (46%), Gaps = 18/213 (8%)
Query: 338 EGQALSEARKHLKEETQLRLDVEKELEMQIS-MRQEMELAMKMLEKDV---CEKQDALVS 393
E QA + + KE Q + KELE + S + +E L + L+ + E ++ V
Sbjct: 860 EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR 919
Query: 394 LRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQRLRQAERS 453
L + +L + HE+ +L+ ++ + +L+ + +MA + LE++L + E +
Sbjct: 920 LAAKKQELEEILHEMEARLE-------EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 972
Query: 454 RQSAELDNRLFKQDFGDKINSLQLEVEELTRQRNQLELELKQEKERRLQNDRSIPGRGSQ 513
RQ +L+ K KI L+ E+ + Q N+L E K +ER ++ +
Sbjct: 973 RQKLQLE----KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1028
Query: 514 -KSESKMDGKHK--MQEENVKLKKPLEESHRLQ 543
K+ +K+ KH+ + E V+LKK + L+
Sbjct: 1029 AKNLTKLKNKHESMISELEVRLKKEEKSRQELE 1061
Score = 49.3 bits (116), Expect = 1e-05
Identities = 65/292 (22%), Positives = 124/292 (42%), Gaps = 42/292 (14%)
Query: 232 QVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKS 291
Q + DF L+D +S+ +I A + E+ + L A + LQ + A E++
Sbjct: 1658 QAQMKDFQRELEDARASRD-----EIFATAKEN---EKKAKSLEADLMQLQEDLAAAERA 1709
Query: 292 NTK-------LTEELAVANN--------------RIITLQEEMERVKEESSYILESNRKG 330
+ L EELA + + RI L+EE+E + + + RK
Sbjct: 1710 RKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKA 1769
Query: 331 PKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDA 390
+Q + +E K E+ R +E++ + S EME A+K K +A
Sbjct: 1770 TQQAEQLSNELATERSTAQKNESA-RQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEA 1828
Query: 391 LVS-LRQQLDDLRALKHELAFKLQSSD-------LGVKQKSELNSRLEEKTNQMAATIKQ 442
++ L +Q++ K L+ D L V+ + ++ + +E+ + A +KQ
Sbjct: 1829 KIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQ 1888
Query: 443 LEQRLRQAERSRQSAELDNRLFKQDFGDKINSLQLEVEELTRQRNQLELELK 494
L+++L +AE Q + R +++ + S E + R+ N L+ +L+
Sbjct: 1889 LKRQLEEAEEESQRINANRRKLQRELDEATES----NEAMGREVNALKSKLR 1936
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 73.9 bits (180), Expect = 4e-13
Identities = 71/285 (24%), Positives = 130/285 (45%), Gaps = 29/285 (10%)
Query: 267 VEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILES 326
+E+ + L N LQ ++ A T+L E R+ ++E+E + E LE
Sbjct: 878 LEQKHSQLTEEKNLLQEQLQA----ETELYAEAEEMRVRLAAKKQELEEILHEMEARLEE 933
Query: 327 NRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCE 386
++DR GQ L RK + ++ LD+E++LE + + RQ+++L E + +
Sbjct: 934 -----EEDR---GQQLQAERKKMAQQM---LDLEEQLEEEEAARQKLQLEKVTAEAKIKK 982
Query: 387 KQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQR 446
+D ++ + Q + L + L ++ + ++ E L + N+ + I +LE R
Sbjct: 983 LEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVR 1042
Query: 447 LRQAERSRQSAELDNRLFK---QDFGDKINSLQLEVEELTRQRNQLELELK--------- 494
L++ E+SRQ E R + DF ++I LQ ++ EL Q + E EL+
Sbjct: 1043 LKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDE 1102
Query: 495 -QEKERRLQNDRSIPGRGSQKSESKMDGKHKMQEENVKLKKPLEE 538
+K L+ R + G S E +D + + + K K+ L E
Sbjct: 1103 IAQKNNALKKIRELEGHISDLQED-LDSERAARNKAEKQKRDLGE 1146
Score = 63.2 bits (152), Expect = 7e-10
Identities = 84/420 (20%), Positives = 174/420 (41%), Gaps = 61/420 (14%)
Query: 170 ALMQKKLSEYMKALINKKELLSEF------YEPNALMMEEEGAIIAGLLVGLNVIDANFC 223
A +Q+ ++ +A+ E L +F + N +E+E A +AG L L
Sbjct: 1192 AQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVE 1251
Query: 224 MKGEDLDSQVGVIDFSMYLKDGNSSKGTEGD------GQITAILDQKNYVEELNRHLNAT 277
K + L++QV + DG ++ D ++ ++ N E L
Sbjct: 1252 HKKKKLEAQVQ--ELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKD 1309
Query: 278 VNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQDRTA 337
V +L +++ ++ + T + + ++ L+EE ++++ +E+ + + T
Sbjct: 1310 VASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1369
Query: 338 EGQALSEARKHLK---------EETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQ 388
Q LS+++K L+ EE + R +KE+E +E A LEK Q
Sbjct: 1370 NIQ-LSDSKKKLQDFASTVEALEEGKKRF--QKEIENLTQQYEEKAAAYDKLEKTKNRLQ 1426
Query: 389 DALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQR-- 446
L L LD+ R L L K + D + ++ ++S+ ++ ++ A ++ E +
Sbjct: 1427 QELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL 1486
Query: 447 -----LRQAERSRQSAELDNRLFKQDFGDKINS-----------------LQLEVEELTR 484
L +A +++ E N++ K + D ++S L+ ++EE+
Sbjct: 1487 SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKT 1546
Query: 485 QRNQLELELKQEKERRL-----------QNDRSIPGRGSQKSESKMDGKHKMQEENVKLK 533
Q +LE EL+ ++ +L Q +R + R Q E + + ++ E +L+
Sbjct: 1547 QLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELE 1606
Score = 62.4 bits (150), Expect = 1e-09
Identities = 76/333 (22%), Positives = 142/333 (42%), Gaps = 80/333 (24%)
Query: 261 LDQKNYVEELNRHLNATVNNLQAKVD-------ALEKSNTKLTEELAVANNRIITLQEEM 313
L+ K +E N+ L A + +L + D LEKS L ++ ++ L++E+
Sbjct: 1496 LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDEL 1555
Query: 314 ERVKEESSYILESNRKGPK----QDRTAEGQALSEARKHLKE-----ETQLR-------- 356
+ E++ LE N + K +D A + E R+ L+ ET+L
Sbjct: 1556 QAT-EDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRAL 1614
Query: 357 ------------LDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRAL 404
D+E + + I R+E A+K L K + +D +++L+D RA
Sbjct: 1615 AAAAKKKLEGDLKDLELQADSAIKGREE---AIKQLRKLQAQMKD----FQRELEDARAS 1667
Query: 405 KHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQRLRQAERSRQSAELDNRLF 464
+ E+ + + E+K + A + QL++ L AER+R+ A+L+
Sbjct: 1668 RDEIFATAKEN--------------EKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL 1713
Query: 465 KQDFGDKI---NSLQLEVEELTRQRNQLELELKQE----------------KERRLQNDR 505
++ + N+LQ E L + QLE EL++E + +L N+
Sbjct: 1714 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1773
Query: 506 SIPGRGSQKSESKMDGKHKMQEENVKLKKPLEE 538
+ +QK+ES + +++ +N +L+ L E
Sbjct: 1774 ATERSTAQKNES---ARQQLERQNKELRSKLHE 1803
Score = 55.8 bits (133), Expect = 1e-07
Identities = 73/322 (22%), Positives = 136/322 (42%), Gaps = 50/322 (15%)
Query: 252 EGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANN---RIIT 308
EGD D + +L + L K + L+ + +L +E+A NN +I
Sbjct: 1061 EGDAS-----DFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRE 1115
Query: 309 LQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLD-VEKELEMQI 367
L+ + ++E+ + K KQ R L E + LK E + LD + E++
Sbjct: 1116 LEGHISDLQEDLDSERAARNKAEKQKRD-----LGEELEALKTELEDTLDSTATQQELRA 1170
Query: 368 SMRQEMELAMKMLEKDVCEKQ-----------DALVSLRQQLDDLRALKHEL-----AFK 411
QE+ + K L+++ + A+ L +QL+ + K L +
Sbjct: 1171 KREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLE 1230
Query: 412 LQSSDLG--VKQKSELNSRLEEKTNQMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFG 469
+++DL ++ + +E K ++ A +++L+ + ER+R AEL+
Sbjct: 1231 KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERAR--AELN--------- 1279
Query: 470 DKINSLQLEVEELTRQRNQLELELKQEKERRLQND-RSIPGRGSQKSESKMDGKHKMQEE 528
DK++ LQ EVE +T N+ E K +L D S+ + E + +
Sbjct: 1280 DKVHKLQNEVESVTGMLNEAE-----GKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV 1334
Query: 529 NVKLKKPLEESHRLQPHPMDEQ 550
+ KL++ EE + LQ +DE+
Sbjct: 1335 STKLRQLEEERNSLQDQ-LDEE 1355
Score = 54.7 bits (130), Expect = 3e-07
Identities = 53/213 (24%), Positives = 100/213 (46%), Gaps = 18/213 (8%)
Query: 338 EGQALSEARKHLKEETQLRLDVEKELEMQIS-MRQEMELAMKMLEKDV---CEKQDALVS 393
E QA + + KE Q + KELE + S + +E L + L+ + E ++ V
Sbjct: 853 EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR 912
Query: 394 LRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQRLRQAERS 453
L + +L + HE+ +L+ ++ + +L+ + +MA + LE++L + E +
Sbjct: 913 LAAKKQELEEILHEMEARLE-------EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 965
Query: 454 RQSAELDNRLFKQDFGDKINSLQLEVEELTRQRNQLELELKQEKERRLQNDRSIPGRGSQ 513
RQ +L+ K KI L+ E+ + Q N+L E K +ER ++ +
Sbjct: 966 RQKLQLE----KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1021
Query: 514 -KSESKMDGKHK--MQEENVKLKKPLEESHRLQ 543
K+ +K+ KH+ + E V+LKK + L+
Sbjct: 1022 AKNLTKLKNKHESMISELEVRLKKEEKSRQELE 1054
Score = 49.3 bits (116), Expect = 1e-05
Identities = 65/292 (22%), Positives = 124/292 (42%), Gaps = 42/292 (14%)
Query: 232 QVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKS 291
Q + DF L+D +S+ +I A + E+ + L A + LQ + A E++
Sbjct: 1651 QAQMKDFQRELEDARASRD-----EIFATAKEN---EKKAKSLEADLMQLQEDLAAAERA 1702
Query: 292 NTK-------LTEELAVANN--------------RIITLQEEMERVKEESSYILESNRKG 330
+ L EELA + + RI L+EE+E + + + RK
Sbjct: 1703 RKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKA 1762
Query: 331 PKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDA 390
+Q + +E K E+ R +E++ + S EME A+K K +A
Sbjct: 1763 TQQAEQLSNELATERSTAQKNESA-RQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEA 1821
Query: 391 LVS-LRQQLDDLRALKHELAFKLQSSD-------LGVKQKSELNSRLEEKTNQMAATIKQ 442
++ L +Q++ K L+ D L V+ + ++ + +E+ + A +KQ
Sbjct: 1822 KIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQ 1881
Query: 443 LEQRLRQAERSRQSAELDNRLFKQDFGDKINSLQLEVEELTRQRNQLELELK 494
L+++L +AE Q + R +++ + S E + R+ N L+ +L+
Sbjct: 1882 LKRQLEEAEEESQRINANRRKLQRELDEATES----NEAMGREVNALKSKLR 1929
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 72.4 bits (176), Expect = 1e-12
Identities = 71/302 (23%), Positives = 142/302 (47%), Gaps = 19/302 (6%)
Query: 266 YVEELNRHLNATVNNLQAKV---DALEKSNTKLTEELAVANNRIITLQ---EEMERVKEE 319
Y+EEL + +A L + L+K N +L E+L +A + +Q +E++R E
Sbjct: 160 YIEELTKERDALSLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLER 219
Query: 320 SSYILESNRKGPKQDRT-AEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMK 378
+ ++L + Q+ + + L E K ++++ + E+ L Q +E E M+
Sbjct: 220 AKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMR 279
Query: 379 MLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAA 438
EK + E++ LR+Q +LR K KL+ + ++++ E EEK +
Sbjct: 280 RQEKRLREQEK---ELREQEKELREQK-----KLREQEEQMQEQEEKMWEQEEKMREQEE 331
Query: 439 TIKQLEQRLRQAERSRQSAELDNRLFKQDFGDKINSLQLEVEELTRQRNQLELELKQEKE 498
+ + E+RL + E+ + E R ++ ++ L+ + E + Q E E K ++E
Sbjct: 332 KMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEE 391
Query: 499 RRLQNDRSIPGRGSQKSESKMDGKHKMQEENVKLKKPLEESHRLQPHPMDEQDQLLLSEK 558
R++ +R R +++ + + K + QEEN+ + EE Q +++++L EK
Sbjct: 392 ERIR-EREKKMREEEETMREQEEKMQKQEENMWEQ---EEKEWQQQRLPEQKEKLWEQEK 447
Query: 559 PQ 560
Q
Sbjct: 448 MQ 449
Score = 60.5 bits (145), Expect = 5e-09
Identities = 52/300 (17%), Positives = 134/300 (44%), Gaps = 16/300 (5%)
Query: 262 DQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESS 321
+Q+ + E + + + + L + ++ E+ ++ + E+ ER++E+
Sbjct: 314 EQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEE 373
Query: 322 YILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLE 381
+ E + ++++ E + + E K ++EE + + E++++ Q E E +
Sbjct: 374 RMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQ 433
Query: 382 KDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIK 441
+ +K+ + Q + + + E + Q G ++K ++ E+ +QM
Sbjct: 434 RLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQM----- 488
Query: 442 QLEQRLRQAERSRQSAELDNRLFKQDFGDKINSLQLEVEELTRQRNQLELELKQEKERRL 501
EQ + ++ ++ + + R+++QD L+ + E + Q+ + E K +E++
Sbjct: 489 -WEQEEKMRDQEQKMWDQEERMWEQD-----ERLREKEERMREQKKMWQQEEKMREEKKT 542
Query: 502 QNDRSIPGRGSQKSESKMDGKHKMQEENVKLKKPLEESHRLQPHPMDEQDQLLLSEKPQL 561
Q + + E KM + +M+E K+++ EE R Q M EQ++ + ++ ++
Sbjct: 543 QEQE----KKTWDQEEKMREEERMREREKKMREE-EEMMREQEEKMQEQEEKMREQEEKM 597
Score = 55.8 bits (133), Expect = 1e-07
Identities = 42/254 (16%), Positives = 116/254 (45%), Gaps = 21/254 (8%)
Query: 311 EEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMR 370
++ E+++EE + + ++++ E + + E K ++EE ++ + E++++ Q
Sbjct: 531 QQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKM 590
Query: 371 QEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLE 430
+E E M E+ + E+++ + +++ + E K+Q + + ++ E E
Sbjct: 591 REQEEKMWEQEEKMQEQEEKMWEQEEKM-----WEQEEEDKMQEQEEMMWEQEEKMQEQE 645
Query: 431 EKTNQMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFGDKINSLQLEVEELTRQRNQLE 490
EK + +++ E+++R+ E Q E +K+ + +++ + + E
Sbjct: 646 EKMWEQEEKMREQEEKMREQEEKMQGQE-----------EKMREQEEKMQGQEEKMREQE 694
Query: 491 LELKQEKERRLQNDRSIPGRGSQKSESKMDGKHKMQEENVKLKKPLEESHRLQPHPMDEQ 550
+++ ++E+ + + G+ E KM G+ +M+E+ +++ E+ P +
Sbjct: 695 EKMRGQEEKMWGQEEKMWGQ-----EEKMWGQEEMREKEERIRDQKEKMQERLPEHEERC 749
Query: 551 DQLLLSEKPQLCQL 564
+ L LC +
Sbjct: 750 SEPCLPPSKVLCNM 763
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 72.4 bits (176), Expect = 1e-12
Identities = 86/397 (21%), Positives = 169/397 (42%), Gaps = 34/397 (8%)
Query: 241 YLKDGNSSKGTEGD--GQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEE 298
Y K + K + D G+ + +L + ++ + L+ +L + + + N KL +E
Sbjct: 1021 YEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQN-KLIQE 1079
Query: 299 LAVANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLD 358
L A TL+++ + +++ ++ + K+ E + ++E K L E +++
Sbjct: 1080 LKTAK---ATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSK-LAEIEEIKCR 1135
Query: 359 VEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSS--- 415
EKE+ + +E++ K++ +DA L QQ +L+ L ++
Sbjct: 1136 QEKEIT---KLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRN 1192
Query: 416 -----DLGVKQKSELNSRLEEKTNQMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFGD 470
D K++ EL EK ++ + IK+ E +++ E + + ++ G
Sbjct: 1193 QQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGT 1252
Query: 471 ---KINSLQLEVEELTRQRNQLELEL--------KQEKERRLQNDRSIPGRGS-QKSESK 518
+ S Q V EL +Q + L E+ + ERR +R + G G +K ++K
Sbjct: 1253 VKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTK 1312
Query: 519 -MDGKHKMQEENVKLKKPLEESHRLQ-PHPMDEQDQLLLSEKPQLCQLCQEDGSLT--KN 574
++ + K+ +++ E+ LQ H + + Q C C + S+T ++
Sbjct: 1313 VLELQRKLDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQNCMACGKGFSVTVRRH 1372
Query: 575 VCKNCSGTFCDACSTNELPLPSSIKLERVCNPCHKHL 611
C+ C FC CS PSS K RVC+ C L
Sbjct: 1373 HCRQCGNIFCAECSAKNALTPSSKKPVRVCDACFNDL 1409
Score = 63.2 bits (152), Expect = 7e-10
Identities = 77/357 (21%), Positives = 155/357 (43%), Gaps = 52/357 (14%)
Query: 260 ILDQKNYVEELNRHLNATVNN-------LQAKVDALEKSNTKLTEELAVANNRIITLQEE 312
+L + V ELN LN + ++AK + L + T + A N + T Q
Sbjct: 616 VLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNA 675
Query: 313 MERVKEESSYILESNRK--GPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMR 370
++ ++E + I + QD+ + S+ HLKE + L +E++ E
Sbjct: 676 LQDKQQELNKITTQLDQVTAKLQDKQ---EHCSQLESHLKEYKEKYLSLEQKTE------ 726
Query: 371 QEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLE 430
E+E +K LE D E + + Q L R L +L + ++ + E+ S
Sbjct: 727 -ELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTR 785
Query: 431 EKTNQMAATIKQLEQRLRQAERSRQSAELD-------NRLFKQDFGDKINSLQLEVEELT 483
+ + ++ ++Q+L + E +Q + D ++ ++ ++I + E++++
Sbjct: 786 LDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVK 845
Query: 484 RQRNQLELELKQEKER------RLQNDRSIPGRGSQKSESKM--------DGKHKMQ--- 526
++ L EL K++ L+N +S + +QK ++ + + KH++Q
Sbjct: 846 MEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQM 905
Query: 527 ----EENVKLKKPLE----ESHRLQPHPMDEQDQLLLSEKPQLCQLCQEDGSLTKNV 575
+E +LKK LE SH+L+ Q+QL+ ++ L Q +E+ L N+
Sbjct: 906 ENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQN-TLKQNEKEEQQLQGNI 961
Score = 62.8 bits (151), Expect = 9e-10
Identities = 65/330 (19%), Positives = 152/330 (46%), Gaps = 39/330 (11%)
Query: 268 EELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESN 327
EELN + TV LQ ++ L EL+ +++ + + ++ K E + N
Sbjct: 828 EELNNRIQTTVTELQK----VKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFE---KEN 880
Query: 328 RKGP-------KQDRTAEGQALSEARKHLKEETQLRLDVEKE------LEMQISMRQEME 374
+KG K + + Q + LKE+ +L+ +EKE L+++++ QE
Sbjct: 881 QKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQL 940
Query: 375 L----AMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLE 430
+ +K EK+ + Q + L+Q + + L +L+ + V QK+EL ++L+
Sbjct: 941 IQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELK---IAVLQKTELENKLQ 997
Query: 431 EKTNQMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFGDKINSLQLEVEELTRQRNQLE 490
++ Q A + ++++ + + + ++ + + DF + + L ++L +L
Sbjct: 998 QQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLS 1057
Query: 491 LELKQEKERRLQNDRSIPGRGSQKSESKMDGKHKMQEENVKLKKPLEESHRLQPHPMDE- 549
L + L ++R+ G ++ + K +++++ K ++ L+E + E
Sbjct: 1058 L-----AQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEK 1112
Query: 550 --QDQLLLSEKPQLCQL----CQEDGSLTK 573
+++ L++EK +L ++ C+++ +TK
Sbjct: 1113 SLKEKELVNEKSKLAEIEEIKCRQEKEITK 1142
Score = 61.6 bits (148), Expect = 2e-09
Identities = 67/292 (22%), Positives = 129/292 (44%), Gaps = 22/292 (7%)
Query: 276 ATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQDR 335
A +N LQ K L++ T+LTE+L + QE + +E L + +
Sbjct: 561 AVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLE 620
Query: 336 TAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLR 395
T+ + S+ + ++ +QL + ++ + E+ +S L+ + Q+AL +
Sbjct: 621 TSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQ 680
Query: 396 QQLDDLRALKHELAFKLQSS-------DLGVKQKSELNSRLEEKTNQMAATIKQLEQRLR 448
Q+L+ + ++ KLQ + +K+ E LE+KT ++ IK+LE
Sbjct: 681 QELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSL 740
Query: 449 QAERSRQSAELDNRLFKQDFGDKINSLQLEVEELTRQRNQLELELKQEKERRLQNDRSIP 508
+ + S++ A D + +Q D L+L EL++ QLE+E + RL +
Sbjct: 741 EVKASKEQALQDLQQQRQLNTD----LELRATELSK---QLEMEKEIVSSTRLDLQKK-- 791
Query: 509 GRGSQKSESKMDGKHKMQEENVKLKKPLE---ESHRLQPHPMDEQDQLLLSE 557
S+ ES K +EE LK+ E + ++Q ++ + Q ++E
Sbjct: 792 ---SEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTE 840
Score = 58.2 bits (139), Expect = 2e-08
Identities = 58/272 (21%), Positives = 116/272 (42%), Gaps = 5/272 (1%)
Query: 263 QKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSY 322
+K +E L L V + L++ T+ +ELA +I LQ E+ +E+
Sbjct: 971 KKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEK-SQETFK 1029
Query: 323 ILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEK 382
L+S+ G + + A Q L + L + + ++ Q + QE++ A LE+
Sbjct: 1030 QLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQ 1089
Query: 383 DVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQ 442
D +K+ L + L D++ K +L + + + E+ R E++ ++ +K
Sbjct: 1090 DSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELK- 1148
Query: 443 LEQRLRQAERSRQSAELDNRLFKQ--DFGDKINSLQLEVEELTRQRNQLELELKQEKERR 500
+L + + L +Q + K +SL+ VE+ R + L+ ++K+E+E
Sbjct: 1149 -SHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEEL 1207
Query: 501 LQNDRSIPGRGSQKSESKMDGKHKMQEENVKL 532
+ + + + K G K +E KL
Sbjct: 1208 KKEFIEKEAKLHSEIKEKEVGMKKHEENEAKL 1239
Score = 52.4 bits (124), Expect = 1e-06
Identities = 67/308 (21%), Positives = 130/308 (42%), Gaps = 23/308 (7%)
Query: 260 ILDQKNYVEELNRHLNATVNNLQAKVD-------ALEKSNTKLTEELAVANNRIITLQEE 312
I K+ E+ L + ++++K D A E+ T+LTEEL I L+ E
Sbjct: 154 IKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTE 213
Query: 313 M-ERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQ 371
+ +R E +L K++ + + E++ D K+L+ Q +
Sbjct: 214 LLQRPGIEDVAVL-------KKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYA--- 263
Query: 372 EMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEE 431
E + L ++ + + Q+L L++ +EL K Q+ + +K + ++LEE
Sbjct: 264 SSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEE 323
Query: 432 KTNQMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFGDKINSLQLEVEELTRQRNQLEL 491
K N+ + + K ++ L Q + Q +L +RL + ++ + +E+ E +L+
Sbjct: 324 KHNEESVSKKNIQATLHQKDLDCQ--QLQSRLSASE--TSLHRIHVELSEKGEATQKLKE 379
Query: 492 ELKQEKERRLQNDRSIPGRGSQKSESKMDGKHKMQEENVKLKKPLEESHRL-QPHPMDEQ 550
EL + + + Q+ E + G E N K LE +L + H ++
Sbjct: 380 ELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKE 439
Query: 551 DQLLLSEK 558
+ L SEK
Sbjct: 440 QRQLSSEK 447
Score = 45.8 bits (107), Expect = 1e-04
Identities = 61/273 (22%), Positives = 116/273 (42%), Gaps = 26/273 (9%)
Query: 311 EEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMR 370
E + +S + ESN + D T Q + + + LKEE +++KELE ++
Sbjct: 61 EAVHDAGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQ 120
Query: 371 QEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLE 430
Q+ ++ E Q SL QQL++ Q+ + +KQ +L E
Sbjct: 121 QQEAKPDGLVTDSSAELQ----SLEQQLEE-----------AQTENFNIKQMKDL---FE 162
Query: 431 EKTNQMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFGDKINSLQ-LEVEELTRQRNQL 489
+K Q+A I ++ + + R++AE ++ + +Q L+ E L R +
Sbjct: 163 QKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIED 222
Query: 490 ELELKQE--KERRLQNDRSIPGRGSQKSESKMDGKHKMQEENVKLK---KPLEESHRLQP 544
LK+E + + L ++ ++ ++SE D K+Q + + L P
Sbjct: 223 VAVLKKELVQVQTLMDNMTL--ERERESEKLKDECKKLQSQYASSEATISQLRSELAKGP 280
Query: 545 HPMDEQDQLLLSEKPQLCQLCQEDGSLTKNVCK 577
+ Q L K + +L Q++ +LT+N+ K
Sbjct: 281 QEVAVYVQELQKLKSSVNELTQKNQTLTENLLK 313
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 71.2 bits (173), Expect = 3e-12
Identities = 74/329 (22%), Positives = 152/329 (46%), Gaps = 38/329 (11%)
Query: 268 EELNRHLNATVNNLQAK-------VDALEKSNTKLTEELAVANNRIITLQEEMERVKE-- 318
EE+N L A L+ + +D LE + K+ +E N++ L EEM + E
Sbjct: 930 EEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEII 989
Query: 319 -----ESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEM 373
E + E++++ + E + + + +K E Q+ D+E LE + +R ++
Sbjct: 990 AKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVD-DLEGSLEQEKKVRMDL 1048
Query: 374 ELAMKMLEKDVCEKQDALVSL---RQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLE 430
E A + LE D+ Q++++ L +QQLD+ K F+L + + ++ + L S+L+
Sbjct: 1049 ERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKD---FELNALNARIEDEQALGSQLQ 1105
Query: 431 EKTNQMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFGDKINSLQLEVEELTRQRN-QL 489
+K ++ A I++LE+ L +R E + D ++ + +EE + Q+
Sbjct: 1106 KKLKELQARIEELEEELEAERTARAKVE----KLRSDLSRELEEISERLEEAGGATSVQI 1161
Query: 490 ELELKQE----------KERRLQNDRSIPGRGSQKSESKMD-GKHKMQEENVKLKKPLEE 538
E+ K+E +E LQ++ + + ++S + G+ + VK K E+
Sbjct: 1162 EMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEK 1221
Query: 539 SH-RLQPHPMDEQDQLLLSEKPQLCQLCQ 566
S +L+ + + ++ K L ++C+
Sbjct: 1222 SEFKLELDDVTSNMEQIIKAKANLEKMCR 1250
Score = 68.9 bits (167), Expect = 1e-11
Identities = 72/310 (23%), Positives = 142/310 (45%), Gaps = 37/310 (11%)
Query: 252 EGDGQIT--AILDQKNYVEELNRHLNAT---VNNLQAKVDALEKSNTKLTEELAVANNRI 306
EGD ++T +I+D +N ++L+ L +N L A+++ + ++L ++L RI
Sbjct: 1056 EGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARI 1115
Query: 307 ITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQ 366
L+EE+E + + + + + D + E + +SE + T +++++ K+ E +
Sbjct: 1116 EELEEELEAERTARAKV-----EKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAE 1170
Query: 367 I-SMRQEMELAMKMLEKDVC----EKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQ 421
MR+++E A E + D++ L +Q+D+L+ +K +L K+
Sbjct: 1171 FQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLE----------KE 1220
Query: 422 KSELNSRLEEKTNQMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFGDKINSLQLEVEE 481
KSE L++ T+ M IK +A + L++++ + K Q V +
Sbjct: 1221 KSEFKLELDDVTSNMEQIIK------AKANLEKMCRTLEDQM--NEHRSKAEETQRSVND 1272
Query: 482 LTRQRNQLELELKQEKERRLQNDRSIPG---RGSQKSESKMDGKHKMQEENVKLKKPLEE 538
LT QR +L+ E E R+L ++ RG +++ + EE VK K L
Sbjct: 1273 LTSQRAKLQTE-NGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAH 1331
Query: 539 SHRLQPHPMD 548
+ + H D
Sbjct: 1332 ALQSARHDCD 1341
Score = 61.2 bits (147), Expect = 3e-09
Identities = 72/314 (22%), Positives = 144/314 (45%), Gaps = 40/314 (12%)
Query: 267 VEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILES 326
+E++ + L A LQ+ ALE++ L E +I+ Q E ++K E L
Sbjct: 1526 LEKVRKQLEAEKMELQS---ALEEAEASLEHE----EGKILRAQLEFNQIKAEIERKLAE 1578
Query: 327 NRKGPKQDRTAEGQALSEARKHLKEETQLR---LDVEKELEMQISMRQEMELAMKMLEKD 383
+ +Q + + + + L ET+ R L V+K++E ++ EME+ + +
Sbjct: 1579 KDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLN---EMEIQLSHANRM 1635
Query: 384 VCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRL---EEKTNQMAATI 440
E Q + SL+ L D ++Q D V+ +L + E + N + A +
Sbjct: 1636 AAEAQKQVKSLQSLLKDT---------QIQLDD-AVRANDDLKENIAIVERRNNLLQAEL 1685
Query: 441 KQLEQRLRQAERSRQSAELDNRLFKQDFGDKINSLQLEVEELTRQRNQLELELKQ---EK 497
++L + Q ERSR+ AE + + +++ L + L Q+ +++ +L Q E
Sbjct: 1686 EELRAVVEQTERSRKLAEQE----LIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEV 1741
Query: 498 ERRLQNDRSIPGRGSQK-SESKMDGKHKMQEENV-----KLKKPLEESHRLQPHPMDEQD 551
E +Q R+ + + +++ M + +E++ ++KK +E++ + H +DE +
Sbjct: 1742 EEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAE 1801
Query: 552 QLLL-SEKPQLCQL 564
Q+ L K QL +L
Sbjct: 1802 QIALKGGKKQLQKL 1815
Score = 59.7 bits (143), Expect = 8e-09
Identities = 64/272 (23%), Positives = 131/272 (48%), Gaps = 22/272 (8%)
Query: 282 QAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQA 341
+ ++ ++++ T+L E L + R L+E+M + +E + + + +QD A+ +
Sbjct: 846 EKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDL--QLQVQAEQDNLADAEE 903
Query: 342 LSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDL 401
+ + +K + QL V KE+ ++ +EM + ++ + +D L++ +DDL
Sbjct: 904 RCD--QLIKNKIQLEAKV-KEMNERLEDEEEMNAELTAKKRKL---EDECSELKRDIDDL 957
Query: 402 RALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQRLRQAERSRQSAELDN 461
++ + +++ VK +E + L+E ++ K L++ +QA Q+ E
Sbjct: 958 ELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEE--- 1014
Query: 462 RLFKQDFGDKINSLQLEVEELTRQRNQLELELKQEKERRLQNDRS---IPGRGSQKSESK 518
DK+N+L +L +Q + LE L+QEK+ R+ +R+ + G ES
Sbjct: 1015 --------DKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESI 1066
Query: 519 MDGKHKMQEENVKLKKPLEESHRLQPHPMDEQ 550
MD ++ Q+ + +LKK E + L DEQ
Sbjct: 1067 MDLENDKQQLDERLKKKDFELNALNARIEDEQ 1098
Score = 53.1 bits (126), Expect = 7e-07
Identities = 59/306 (19%), Positives = 132/306 (43%), Gaps = 21/306 (6%)
Query: 248 SKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRII 307
SK E + + Q+ ++ N L+ ++ +A + L + T++L ++
Sbjct: 1261 SKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQL- 1319
Query: 308 TLQEEMERVKEESSYILESNRKGP---KQDRTAEGQALSEARKHLK----EETQLRLDVE 360
EE + K ++ L+S R ++ E +A +E ++ L E Q R E
Sbjct: 1320 ---EEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYE 1376
Query: 361 KELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVK 420
+ I +E+E A K L + + E ++A+ ++ + L KH L +++ + V+
Sbjct: 1377 TDA---IQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVE 1433
Query: 421 QKSELNSRLEEKTNQMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFGDKINSLQLEVE 480
+ + + L++K + + +Q+ +++ +S++ + R + N+ + +E
Sbjct: 1434 RSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLE 1493
Query: 481 EL-TRQRNQLELELKQEKERRLQNDRSIPGRGSQKSESKMDGKHKMQEENVKLKKPLEES 539
L T +R L QE+ L G+ + E + +++ E ++L+ LEE+
Sbjct: 1494 HLETFKRENKNL---QEEISDLTEQLGSSGKTIHELEKV---RKQLEAEKMELQSALEEA 1547
Query: 540 HRLQPH 545
H
Sbjct: 1548 EASLEH 1553
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 70.9 bits (172), Expect = 3e-12
Identities = 79/328 (24%), Positives = 141/328 (42%), Gaps = 49/328 (14%)
Query: 251 TEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQ 310
++ +G I D+K E +Q K D +++ L +EL A+NR+ L+
Sbjct: 1918 SKAEGVIDGYADEKTLFER----------QIQEKTDIIDR----LEQELLCASNRLQELE 1963
Query: 311 EEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMR 370
E ++++EE + + E Q L E K +KE+ +++ EK +R
Sbjct: 1964 AEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEK-------VR 2016
Query: 371 QEMELAMKMLEKDVCEKQDALVSLRQ----QLDDLRALKHELAFKLQSSDLGVKQKSELN 426
+++ +K LE DV E+ + L Q +L DLR L +L+ K E
Sbjct: 2017 DDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMR---KFLDEQA 2073
Query: 427 SRLEEKTNQMAATIKQLEQRLRQAERSRQSAELDNRLFKQ------DFGDKINSLQLEVE 480
E + + I++LEQ+L+ R + +E R +Q + DK + L L E
Sbjct: 2074 IDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKE 2133
Query: 481 ELTR---QRNQ----LELELKQEKERRLQNDRSIPGRGSQKSE--------SKMDGKHKM 525
+L R +RN+ LE +++ ++ L DR G K E ++ D +
Sbjct: 2134 QLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRK 2193
Query: 526 QEENVKLKKPLEESHRLQPHPMDEQDQL 553
++E L++ LE+ + +E QL
Sbjct: 2194 EKEITNLEEQLEQFREELENKNEEVQQL 2221
Score = 59.7 bits (143), Expect = 8e-09
Identities = 88/387 (22%), Positives = 162/387 (41%), Gaps = 47/387 (12%)
Query: 225 KGEDLDSQVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVEELNRHL---NATVNNL 281
K ED Q+ + + + + K E + I +++ +EELN + L
Sbjct: 290 KKEDFTMQISFLQEKIKVYEMEQDKKVENSNK-EEIQEKETIIEELNTKIIEEEKKTLEL 348
Query: 282 QAKVDALEKSNTKLTEELAVANNRI------ITLQEEMERVKEESSYILESNRKGPKQDR 335
+ K+ +K +L E++ N I +T ++ ER E L + ++
Sbjct: 349 KDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRN 408
Query: 336 TAEGQALSEARKHLKEETQLRLD-VEKELE----------MQISMRQEMELAMKMLEKDV 384
+ Q ++ + +++ETQ +L+ + EL+ Q +RQ M +M +
Sbjct: 409 HKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHK 468
Query: 385 CEKQDALVSL------RQQLDDLRALKHELAFKLQSSDLGV-KQKSELNSRLEEKT---N 434
E ++AL S Q+ + +EL KLQ ++ K K EL LEEK
Sbjct: 469 GEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQR 528
Query: 435 QMAATIKQLEQRLRQAERSRQS-AELDNRLFKQDFG-DKINSLQLEVEELTRQRNQLELE 492
Q+ +++L Q +R+RQ+ AE +++L + + L+ E+ + R +LEL+
Sbjct: 529 QLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELK 588
Query: 493 LKQE------------KERRLQNDRSIPGRGSQKSESKMDGKHKMQEENVKLKKPLEESH 540
+ E KE+ DR + ++ + +EE KLK+ LE H
Sbjct: 589 HEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEH 648
Query: 541 RLQPHPMDEQDQLLLSEKPQLCQLCQE 567
R+ + +D L + K Q+ L E
Sbjct: 649 RINIEKL--KDNLGIHYKQQIDGLQNE 673
Score = 58.2 bits (139), Expect = 2e-08
Identities = 78/333 (23%), Positives = 142/333 (42%), Gaps = 37/333 (11%)
Query: 248 SKGTEGDGQITAILDQKNY----VEELNRHLNATVNN-LQAKVDALEKSNTKLTEELAVA 302
SK TE +++ L + + ++ N L +++ LQA V+ L ++ ++ + +L A
Sbjct: 1812 SKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHA 1871
Query: 303 NNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKE 362
L E R K+E++ L+ E R+ L EE++ R + E
Sbjct: 1872 KVTQTELMRESFRQKQEATESLKCQE---------------ELRERLHEESRAREQLAVE 1916
Query: 363 LEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQK 422
L + + E+ + EK D + L Q+L EL + Q ++++
Sbjct: 1917 LSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQ----IQEE 1972
Query: 423 SELNSRLEEKTNQMAATI-KQLEQRLRQAERSRQSAELDNRLFKQDFGDKINSLQLEVEE 481
EL SR +E A + +QL Q + + + + + D ++ +L+++VEE
Sbjct: 1973 RELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEE 2032
Query: 482 LTRQRNQLELELKQE-KERRLQN---DRSIPGRGSQKSESKMDGKHK---MQEENVKLKK 534
+ +LE E E + R QN ++ + E +D +H+ Q+E KL++
Sbjct: 2033 QVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQ 2092
Query: 535 PLEESHRLQP---HPMDEQDQLL--LSEKPQLC 562
L+ R QP H E +QL L EK C
Sbjct: 2093 QLKVVPRFQPISEHQTREVEQLANHLKEKTDKC 2125
Score = 52.8 bits (125), Expect = 1e-06
Identities = 80/377 (21%), Positives = 165/377 (43%), Gaps = 55/377 (14%)
Query: 224 MKGEDLDSQVGVIDFSMYLKDGNSSKGTEG--------------DG---QITAILDQ--- 263
M+ E Q + + + L++ + GTEG DG Q+TA L Q
Sbjct: 160 MESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARR 219
Query: 264 ------KNYVE--ELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMER 315
+ ++E E ++ L LQA +++ +L A +I+T Q+++
Sbjct: 220 EKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQL-- 277
Query: 316 VKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMEL 375
EE ++LE +K K+D T + L E K + E +++ + E+ QE E
Sbjct: 278 --EEQDHLLEDYQK-KKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEI-----QEKET 329
Query: 376 AMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQ 435
++ L + E++ + L+ +L L EL ++ + +K + ++K Q
Sbjct: 330 IIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQ 389
Query: 436 MAATIKQL-----EQRLRQAERSRQSAELDNRLFKQDFGDKINSLQLEVEELTRQR-NQL 489
+ IKQL E + R + S+ ++ R+ +Q+ K+ L+ E++E+ Q+ Q+
Sbjct: 390 SSEEIKQLMGTVEELQKRNHKDSQFETDIVQRM-EQETQRKLEQLRAELDEMYGQQIVQM 448
Query: 490 ELELKQEKERRLQNDRSIPGRGSQKSESKMDGKHKMQEENVKLKK--------PLEESHR 541
+ EL ++ +++ + +G ++ + + E+ +KL L++++
Sbjct: 449 KQELIRQHMAQME-EMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNS 507
Query: 542 LQPHPMDEQDQLLLSEK 558
Q + E+ L+L EK
Sbjct: 508 -QKEKLKEELGLILEEK 523
Score = 49.3 bits (116), Expect = 1e-05
Identities = 78/351 (22%), Positives = 142/351 (40%), Gaps = 73/351 (20%)
Query: 268 EELNRHLNATVNNLQAKVDALEKSNTKLTEELAVA-------NNRIITLQEEMERVKEES 320
++ +R L + +AK+ E+ + + E+L + N ++ L E+ +++ ES
Sbjct: 3206 QKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNES 3265
Query: 321 SYILESNRK------GPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQ--- 371
+ES R +Q R E Q L E+ K E LD E+EL Q+
Sbjct: 3266 QQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTG 3325
Query: 372 ------EMELAMKMLEKDVCEKQDALVSL--------------RQQLD-DLRALKHELAF 410
E +K L+K + EK +V L RQQ++ D + + L
Sbjct: 3326 QSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQT 3385
Query: 411 KLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFGD 470
+ +++ G K+ EL S++E+ L+++L + + +L+ + Q
Sbjct: 3386 EQEANTEGQKKMHELQSKVED-----------LQRQLEEKRQQVYKLDLEGQRL-QGIMQ 3433
Query: 471 KINSLQLEVEELTRQRNQLELELKQEKERRLQNDRS--------IPGRGSQKSESK---M 519
+ +LE EE R L L + L +DR+ I G + + +K M
Sbjct: 3434 EFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEM 3493
Query: 520 DG-----KHKMQEENVKLK--------KPLEESHRLQPHPMDEQDQLLLSE 557
+G H+++ KL+ P + S RLQ D++D + + E
Sbjct: 3494 NGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQE 3544
Score = 47.8 bits (112), Expect = 3e-05
Identities = 55/246 (22%), Positives = 112/246 (45%), Gaps = 19/246 (7%)
Query: 256 QITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMER 315
+IT + +Q E + N V L +++ +K +T +EL N +++ME+
Sbjct: 2196 EITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENK---LFKDDMEK 2252
Query: 316 ----VKE------ESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEM 365
+KE + ++L Q++ E L+E L+++ ++ D K +E
Sbjct: 2253 LGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTD-NKVIEE 2311
Query: 366 QISMRQEMELAMKMLEKDV-CEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSE 424
+ + +++E ++ L D C K++ + Q + + L+ ELA Q + + SE
Sbjct: 2312 KNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSE 2371
Query: 425 LNSRLEEKTNQMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFGDKINSLQLEVEELTR 484
L+ + + + A LEQ++ A + + + N L + +F K+N L E+ L R
Sbjct: 2372 EADSLKHQLDVVIAEKLALEQQVETA--NEEMTFMKNVLKETNF--KMNQLTQELFSLKR 2427
Query: 485 QRNQLE 490
+R +E
Sbjct: 2428 ERESVE 2433
Score = 47.0 bits (110), Expect = 5e-05
Identities = 70/325 (21%), Positives = 144/325 (44%), Gaps = 46/325 (14%)
Query: 269 ELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNR 328
EL + N + +L+ + ALEK K+ + L + + I + E + ++E + + +
Sbjct: 2039 ELEQEKNTELMDLRQQNQALEKQLEKMRKFL---DEQAIDREHERDVFQQEIQKLEQQLK 2095
Query: 329 KGPKQDRTAEGQA--LSEARKHLKEETQLRLDV---EKELEMQISMRQEMELAMKMLEKD 383
P+ +E Q + + HLKE+T ++ +++L+ I R E ++ LE
Sbjct: 2096 VVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNE---EIEKLEFR 2152
Query: 384 VCEKQDAL-VSLRQQLDDLRALKHELAFKLQ------SSDLGVKQKSELNSRLEE----- 431
V E + AL V R+ + A K EL+ ++Q + D K+ + L +LE+
Sbjct: 2153 VRELEQALLVEDRKHFGAVEA-KPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREEL 2211
Query: 432 --KTNQMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFGDKINSLQLEVEELTRQRNQL 489
K ++ QLE + +++ Q E +N+LFK D +L
Sbjct: 2212 ENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDM------------------EKL 2253
Query: 490 ELELKQEKERRLQNDRSIPGRGSQKSESKMDGKHKMQEENVKLKKPLEESHRLQPHPMDE 549
L +K+ Q+ + G+ +Q + K ++ E+ KL++ L+ + ++E
Sbjct: 2254 GLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKIT--TDNKVIEE 2311
Query: 550 QDQLLLSEKPQLCQLCQEDGSLTKN 574
+++L+ + Q+ L + + +N
Sbjct: 2312 KNELIRDLETQIECLMSDQECVKRN 2336
Score = 46.6 bits (109), Expect = 7e-05
Identities = 53/235 (22%), Positives = 105/235 (44%), Gaps = 35/235 (14%)
Query: 333 QDRTAEGQALSEA-----RKHLKEETQLRLDVEKELEMQISMRQEMEL-AMKMLEKDVCE 386
Q++ E QA E R+ L E Q ++ + QE E + ++LE ++ +
Sbjct: 3061 QEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQ 3120
Query: 387 KQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQR 446
KQ ++ ++ +L ++ EL +L S + V +EL S L + ++ T+K +
Sbjct: 3121 KQSQMLEMQVELSSMKDRATELQEQLSSEKMVV---AELKSELAQTKLELETTLKAQHKH 3177
Query: 447 LRQAERSRQSAELDNRLFKQDFGDKINSLQLEVEEL-TRQRNQLELELKQEKERRLQNDR 505
L++ E F+ + DK + + L + L + Q+ EL+ EKE +
Sbjct: 3178 LKELE-----------AFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKE------K 3220
Query: 506 SIPGRGSQKSESKMDGKHKMQEENVKLKKPLEESHRLQPHPMDEQDQLLLSEKPQ 560
+ GR ++ + ++ E++K ++ LQ + + EQ + LL+E Q
Sbjct: 3221 AKLGRSEERDKEEL--------EDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQ 3267
Score = 45.1 bits (105), Expect = 2e-04
Identities = 64/297 (21%), Positives = 127/297 (42%), Gaps = 33/297 (11%)
Query: 270 LNRH-LNATVNNLQAKVD-------ALEKSNTKLTEELAVANNRIITLQEEMERVKEESS 321
+N H L+ ++L+ ++D ALE+ EE+ N + +M ++ +E
Sbjct: 2364 MNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQEL- 2422
Query: 322 YILESNRKGPKQDRTAEGQALSEARKHLKE-----ETQLRLDVEKELEMQISMRQ----- 371
+ L+ R+ ++ ++ +++ A HL + E L D K LE Q +
Sbjct: 2423 FSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENG 2482
Query: 372 -----EMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSE-- 424
+E + LE V K L +Q+ D++ LQ + +++ E
Sbjct: 2483 KGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEK 2542
Query: 425 ----LNSRLEEKTNQMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFGDKINSLQLEVE 480
L S+++ + Q A Q Q + +E R + + N+L + + G I++L L +
Sbjct: 2543 VAAALVSQIQLEAVQEYAKFCQDNQTI-SSEPERTNIQNLNQLREDELGSDISALTLRIS 2601
Query: 481 ELTRQRNQLELELKQEKERRLQNDRSIPGRGSQKSESK--MDGKHKMQEENVKLKKP 535
EL Q ++ L EKE+ ++++ + + E + ++G K Q E K + P
Sbjct: 2602 ELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSP 2658
Score = 39.3 bits (90), Expect = 0.011
Identities = 70/357 (19%), Positives = 148/357 (41%), Gaps = 56/357 (15%)
Query: 261 LDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEES 320
++ + +E+L +L + + ++D L+ ++ E + + +IT Q ++ +
Sbjct: 646 IEHRINIEKLKDNLGI---HYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKL 702
Query: 321 SYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKML 380
+ +S ++ T + L + + L++E + + +E+E++ + +E MK
Sbjct: 703 KDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEK 762
Query: 381 EKDVCEK-------QDALVSLRQQLDDLRAL------KHELAF----KLQSSDLGVKQKS 423
E D+ EK L ++ L+D+ + + L F K +S D +++
Sbjct: 763 ENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEI 822
Query: 424 ELNSRLEEKTNQMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFGDKINSLQLEVEELT 483
E+ L E+ + QL + + + + AE + + Q+ ++ L ++L
Sbjct: 823 EI---LIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLE 879
Query: 484 RQRNQLELELKQE-----KERRLQ--NDRSIPGRGSQKSESK--------------MDGK 522
+N+ ELE K + +E LQ N ++ + S E K D
Sbjct: 880 DSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTT 939
Query: 523 HKMQEENVKLKKPLEESHRL--------QPHP----MDEQDQLLLSEKPQLCQLCQE 567
M++ V ++ LE S RL Q H ++E+ + L EK Q+ C+E
Sbjct: 940 ELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRE 996
Score = 35.4 bits (80), Expect = 0.16
Identities = 62/319 (19%), Positives = 129/319 (40%), Gaps = 53/319 (16%)
Query: 261 LDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEE-------- 312
L+ + Y + + ++ NL+ ++ LE + + EL +I +QE+
Sbjct: 2469 LENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEML 2528
Query: 313 ------MERVKEE-------SSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLD- 358
++++ EE S LE+ ++ K + + + R +++ QLR D
Sbjct: 2529 QKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDE 2588
Query: 359 ---------------VEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRA 403
+ +EM S+ E E +++ EK+V EK+ L+ L++ L+
Sbjct: 2589 LGSDISALTLRISELESQVVEMHTSLILEKE-QVEIAEKNVLEKEKKLLELQKLLEGNEK 2647
Query: 404 LKHELAFKLQSSDLGV----------KQKSELNSRLEEKTNQMAATIKQLEQRLRQAERS 453
+ E K D+ V ++S + LE + AT +L +AE+
Sbjct: 2648 KQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKL 2707
Query: 454 RQS---AELDNRLFKQDFGDKINSLQLEVEELTRQRNQLELELKQEKERRLQNDRSIPGR 510
++ E + ++D + L E+L+ + E E+++ K+ + +P +
Sbjct: 2708 QEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACM--FEPLPIK 2765
Query: 511 GSQKSESKMDGKHKMQEEN 529
S+ S+ DG K+ N
Sbjct: 2766 LSKSIASQTDGTLKISSSN 2784
Score = 34.3 bits (77), Expect = 0.35
Identities = 68/310 (21%), Positives = 126/310 (40%), Gaps = 53/310 (17%)
Query: 167 LRLALMQKKLSEYMKALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKG 226
LR++ ++ ++ E +LI +KE + E E N L E++ + LL G K
Sbjct: 2598 LRISELESQVVEMHTSLILEKEQV-EIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKR 2656
Query: 227 EDLDSQVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVD 286
D V V+ + L N G N +E L AT +A++
Sbjct: 2657 SPQD--VEVLKTTTELFHSNEESGFF------------NELEALRAESVAT----KAELA 2698
Query: 287 ALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEAR 346
+ ++ KL EEL V + +LQ+++ +V++ L+EA+
Sbjct: 2699 SYKEKAEKLQEELLVKETNMTSLQKDLSQVRDH----------------------LAEAK 2736
Query: 347 KHLKEETQLRLDVEKELEMQISMRQEM-ELAMKMLEKDVCEKQDALVSLRQQLDDLRALK 405
+ L L+ E E E+Q S + M E L K + + D + + + L
Sbjct: 2737 EKLS-----ILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILV 2791
Query: 406 HELAFKLQ-SSDLGVKQKSELNSRLEEKTNQM----AATIKQLEQR-LRQAERSRQSAEL 459
++ S+ ++ +E+ S+ EK +M AA I +E R + + E ++ +
Sbjct: 2792 KNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYV 2851
Query: 460 DNRLFKQDFG 469
+L K++ G
Sbjct: 2852 AVQLLKEECG 2861
Score = 33.1 bits (74), Expect = 0.78
Identities = 31/150 (20%), Positives = 67/150 (44%), Gaps = 23/150 (15%)
Query: 317 KEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISM---RQEM 373
KE S + N QD E Q E L + + L+ ++S +Q
Sbjct: 1227 KENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTD 1286
Query: 374 ELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNS------ 427
+ ++ E+++ +++ +S+ Q+ +L D+ V KS+L+S
Sbjct: 1287 GMKLEFGEENLPKEETEFLSIHSQMTNLE-------------DIDVNHKSKLSSLQDLEK 1333
Query: 428 -RLEEKTNQMAATIKQLEQRLRQAERSRQS 456
+LEE+ ++ + I L+Q+L++ E++ ++
Sbjct: 1334 TKLEEQVQELESLISSLQQQLKETEQNYEA 1363
Score = 32.7 bits (73), Expect = 1.0
Identities = 94/458 (20%), Positives = 172/458 (37%), Gaps = 75/458 (16%)
Query: 171 LMQKKLSEYMKALINKKELLS-----------EFYEPNALMMEEEGAIIAGLLVGLNVID 219
L+ K EY K L+ + L EF E N E E I + L ID
Sbjct: 1259 LLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDID 1318
Query: 220 ANFCMKGEDLDSQVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVN 279
N K L S L+D +K E + + ++ + L + L T
Sbjct: 1319 VNHKSK---LSS----------LQDLEKTKLEE------QVQELESLISSLQQQLKETEQ 1359
Query: 280 NLQAKVDALEKSNTKLTEELAVAN---NRIITLQEEMERVKEESSYILE--------SNR 328
N +A++ L+K ++E + + ++ + + +R S + + S
Sbjct: 1360 NYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGE 1419
Query: 329 KGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKD----- 383
G K++ + ++ L+EE + + M I+ Q+ EL+ K+
Sbjct: 1420 FGVKEETNIVKLLEKQYQEQLEEEVAKVI-----VSMSIAFAQQTELSRISGGKENTASS 1474
Query: 384 -----VCEKQDAL---VSLRQ-----QLDDLRALKHELAFKLQSSDLGVKQKSELNSRLE 430
VC+++ + L Q Q + +K + FK S +LG K L S +
Sbjct: 1475 KQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSD 1534
Query: 431 E----KTNQMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFGDKI--NSLQLEV--EEL 482
++ TI + + RQS + + D ++ N QLE +EL
Sbjct: 1535 PHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQEL 1594
Query: 483 TRQ--RNQLELELKQEKERRLQNDRSIPGRGSQKSESKMDGKHKMQEENVKLKKPLEESH 540
RQ +Q EL ++ R Q +R + + E K + Q ++ + + E
Sbjct: 1595 VRQYQEHQQATELLRQAHMR-QMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERE 1653
Query: 541 RLQPHPMDEQDQLLLSEKPQLCQLCQEDGSLTKNVCKN 578
R+ ++ QL L+ + +LC + + T+N +N
Sbjct: 1654 RVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNEN 1691
Score = 31.6 bits (70), Expect = 2.3
Identities = 42/209 (20%), Positives = 84/209 (40%), Gaps = 29/209 (13%)
Query: 256 QITAILDQ-KNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEME 314
Q+ +L+Q K + E + + + A++ + N +L L RI + ++
Sbjct: 3250 QLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLD 3309
Query: 315 RVKEESSYILESNRKG------PKQDRTAEGQA------------LSEARKHLKEETQLR 356
R +E + + S+ G P +D E Q L+E K+ + Q R
Sbjct: 3310 RERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTR 3369
Query: 357 LDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAF------ 410
+EK+ ++ Q + A +K + E Q + L++QL++ R ++L
Sbjct: 3370 QQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQ 3429
Query: 411 ----KLQSSDLGVKQKSELNSRLEEKTNQ 435
+ Q +L ++K E L + N+
Sbjct: 3430 GIMQEFQKQELEREEKRESRRILYQNLNE 3458
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 70.9 bits (172), Expect = 3e-12
Identities = 71/325 (21%), Positives = 146/325 (44%), Gaps = 47/325 (14%)
Query: 262 DQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESS 321
++ ++ + + A + +L+ ++D E + KL E A +I ++EE+ +++++S
Sbjct: 936 ERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNS 995
Query: 322 YILESNRKGPKQDRTAE-GQALSEARKHLKEETQLR-------LDVEKELEMQISMRQEM 373
++ + +DR AE L+E + K ++R D+E+ L+ + RQE+
Sbjct: 996 KFIKEKKL--MEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQEL 1053
Query: 374 ELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKT 433
E A + L+ + + QD + L+ Q+D+L+ + +LQ + ++ + +
Sbjct: 1054 EKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVV 1113
Query: 434 NQMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFGDKINSLQLEVEELTRQRNQLELEL 493
++ A I +L++ + SR AE K+D +++ +L+ E+E+ T + EL
Sbjct: 1114 RELQAQIAELQEDFESEKASRNKAEKQ----KRDLSEELEALKTELED-TLDTTAAQQEL 1168
Query: 494 KQEKERRLQNDRSIPGRGSQKSESKMDGKHKMQEENVKLKKPLEE---SHRLQPHPMDEQ 550
+ ++E +E +LKK LEE +H Q M ++
Sbjct: 1169 RTKRE----------------------------QEVAELKKALEEETKNHEAQIQDMRQR 1200
Query: 551 DQLLLSE-KPQLCQLCQEDGSLTKN 574
L E QL Q + +L KN
Sbjct: 1201 HATALEELSEQLEQAKRFKANLEKN 1225
Score = 68.6 bits (166), Expect = 2e-11
Identities = 73/316 (23%), Positives = 145/316 (45%), Gaps = 46/316 (14%)
Query: 261 LDQKNYVEELNRHLNATVNNLQAKVD-------ALEKSNTKLTEELAVANNRIITLQEEM 313
L+ K E N+ L A + +L + D LEKS L +++ ++ L++E+
Sbjct: 1496 LEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDEL 1555
Query: 314 ERVKEESSYILESNRKGPKQD-----RTAEGQALSEARKHLKEETQLRLDVE---KELEM 365
+ E++ LE N + K +T + Q + R +K+ +L ++E K+ +
Sbjct: 1556 QAT-EDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRAL 1614
Query: 366 QISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSEL 425
++ +++ME+ +K LE + A + +QL L+A + +L+ + +
Sbjct: 1615 AVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQ 1674
Query: 426 NSRLEEKTNQMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFGDKI-------NSLQLE 478
+ E+K + A I QL++ L +ER+R+ AE + + + D+I ++L E
Sbjct: 1675 SKESEKKLKSLEAEILQLQEELASSERARRHAEQE----RDELADEITNSASGKSALLDE 1730
Query: 479 VEELTRQRNQLELELKQEKER-RLQNDR---------------SIPGRGSQKSESKMDGK 522
L + QLE EL++E+ L NDR + +QKS+ + +
Sbjct: 1731 KRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSD---NAR 1787
Query: 523 HKMQEENVKLKKPLEE 538
+++ +N +LK L+E
Sbjct: 1788 QQLERQNKELKAKLQE 1803
Score = 60.5 bits (145), Expect = 5e-09
Identities = 60/297 (20%), Positives = 125/297 (42%), Gaps = 12/297 (4%)
Query: 267 VEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERV---KEESSYI 323
V+E + + ++ K L + L E+L +E R+ K+E I
Sbjct: 864 VKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEI 923
Query: 324 LESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKD 383
L + + ++ Q L +K ++ Q D+E++L+ + RQ+++L E
Sbjct: 924 LH-DLESRVEEEEERNQILQNEKKKMQAHIQ---DLEEQLDEEEGARQKLQLEKVTAEAK 979
Query: 384 VCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQL 443
+ + ++ ++ L Q K + ++ + ++ E L + N+ I L
Sbjct: 980 IKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDL 1039
Query: 444 EQRLRQAERSRQSAELDNRLF---KQDFGDKINSLQLEVEELTRQRNQLELELKQEKERR 500
E+RL++ E++RQ E R D D+I LQ +++EL Q + E EL+ R
Sbjct: 1040 EERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALAR- 1098
Query: 501 LQNDRSIPGRGSQKSESKMDGKHKMQEENVKLKKPLEESHRLQPHPMDEQDQLLLSE 557
+D ++ + K ++ + +E+ + +K Q + E+ + L +E
Sbjct: 1099 -GDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTE 1154
Score = 51.6 bits (122), Expect = 2e-06
Identities = 63/332 (18%), Positives = 138/332 (41%), Gaps = 30/332 (9%)
Query: 247 SSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAK--------------VDALEKSN 292
SS+ + + + ++ +Q+ EE ++L V LQ++ +++LE++
Sbjct: 1335 SSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAK 1394
Query: 293 TKLTEELAVANNRI---ITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKH- 348
KL ++ + R+ +++E+ K L+ R + +K
Sbjct: 1395 KKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFD 1454
Query: 349 --LKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKH 406
L EE + +E + + +E E L + + E +A +Q LRA
Sbjct: 1455 QLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADME 1514
Query: 407 ELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQRLRQAERSRQSAELDNRLFKQ 466
+L V + + LE++ +M +++LE L+ E ++ E++ + K
Sbjct: 1515 DLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKA 1574
Query: 467 DFGDKINSLQLEVEE----LTRQRNQLELELKQEKERRLQNDRSIPGRGSQKSESKM-DG 521
F + + + EE L +Q +LE EL+ E+++ R++ +K E + D
Sbjct: 1575 QFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQ-----RALAVASKKKMEIDLKDL 1629
Query: 522 KHKMQEENVKLKKPLEESHRLQPHPMDEQDQL 553
+ +++ N + +++ +LQ D Q +L
Sbjct: 1630 EAQIEAANKARDEVIKQLRKLQAQMKDYQREL 1661
Score = 48.9 bits (115), Expect = 1e-05
Identities = 51/205 (24%), Positives = 92/205 (44%), Gaps = 13/205 (6%)
Query: 336 TAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLR 395
T + + L + L + + + VE ELE Q++ +L + + + +
Sbjct: 848 TRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAE 907
Query: 396 QQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQRLRQAERSRQ 455
+ L A K EL L + V+++ E N L+ + +M A I+ LE++L + E +RQ
Sbjct: 908 EMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQ 967
Query: 456 SAELDNRLFKQDFGDKINSLQLEVEELTRQRNQLELELKQEKERRLQNDRSIPGRGSQKS 515
+L+ K KI ++ E+ L Q + K KE++L DR I SQ +
Sbjct: 968 KLQLE----KVTAEAKIKKMEEEILLLEDQNS------KFIKEKKLMEDR-IAECSSQLA 1016
Query: 516 ESKMDGKH--KMQEENVKLKKPLEE 538
E + K+ K++ + + LEE
Sbjct: 1017 EEEEKAKNLAKIRNKQEVMISDLEE 1041
Score = 48.5 bits (114), Expect = 2e-05
Identities = 51/244 (20%), Positives = 105/244 (43%), Gaps = 9/244 (3%)
Query: 254 DGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEM 313
+ +I + ++ E RH + L ++ + L +E RI L+EE+
Sbjct: 1686 EAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEEL 1745
Query: 314 ERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEM 373
E + + + RK Q T + +E R ++ R +E++ + + QE+
Sbjct: 1746 EEEQSNMELLNDRFRKTTLQVDTLNAELAAE-RSAAQKSDNARQQLERQNKELKAKLQEL 1804
Query: 374 ELAMKMLEKDVCEKQDALVS-LRQQLDDL---RALKHELAF----KLQSSDLGVKQKSEL 425
E A+K K +A + L +QL+ RA ++L KL+ + V+ +
Sbjct: 1805 EGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRH 1864
Query: 426 NSRLEEKTNQMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFGDKINSLQLEVEELTRQ 485
+ +E+ + A +KQL+++L +AE A R +++ D + + E++
Sbjct: 1865 ADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTL 1924
Query: 486 RNQL 489
+N+L
Sbjct: 1925 KNRL 1928
Score = 39.3 bits (90), Expect = 0.011
Identities = 63/320 (19%), Positives = 140/320 (43%), Gaps = 47/320 (14%)
Query: 267 VEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSY---- 322
V EL + L N +A++ + + + EEL+ + + +E+ K+
Sbjct: 1176 VAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKE 1235
Query: 323 ------ILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDV-------EKELEMQISM 369
+L+ + + R + E + E +LR+++ + EL+ ++
Sbjct: 1236 LACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTL 1295
Query: 370 RQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKL-----QSSDLGVKQKSE 424
+E E KD + L ++ L + K L+ ++ + + L +Q+ E
Sbjct: 1296 LEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEE 1355
Query: 425 LNSR--LEEKT----NQMAATIKQLE------QRLRQAERS--RQSAELDNRLFKQDFG- 469
+R LE++ +Q+A T K+++ + L +A++ + + L RL ++
Sbjct: 1356 EEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAY 1415
Query: 470 DKI----NSLQLEVEELT-----RQRNQLELELKQEK-ERRLQNDRSIPGRGSQKSESKM 519
DK+ N LQ E+++LT +++ LE KQ+K ++ L ++SI R +++ +
Sbjct: 1416 DKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAE 1475
Query: 520 DGKHKMQEENVKLKKPLEES 539
+ + + + L + LEE+
Sbjct: 1476 AEAREKETKALSLARALEEA 1495
>gi|34577114 cytomatrix protein p110 [Homo sapiens]
Length = 957
Score = 70.9 bits (172), Expect = 3e-12
Identities = 74/353 (20%), Positives = 160/353 (45%), Gaps = 28/353 (7%)
Query: 229 LDSQVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDAL 288
L ++V + + K+ +K T+ Q+ + ++K + R + + + K++ L
Sbjct: 488 LQTEVDALRLRLEEKESFLNKKTK---QLQDLTEEKGTLAGEIRDMKDMLEVKERKINVL 544
Query: 289 EKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKH 348
+K L E+L + ++ L++ ++ ++ +SS ++ +E + + E K
Sbjct: 545 QKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSN--TDTALATLEEALSEKERIIERLKE 602
Query: 349 LKEETQLRLDVEKELEMQISMRQEMELAMKM--LEKDVCEKQDALVSLRQQLDDLRALKH 406
+E R D E+ E++ ++ +L K+ L+ ++ EK+ +L+ L++ L +
Sbjct: 603 QRE----RDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGL 658
Query: 407 ELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQRLRQAERSRQSAELDNRLFKQ 466
+ KL+S ++ ++QK E S+LE QL++ + SR + E +++ +
Sbjct: 659 KRDSKLKSLEIAIEQKKEECSKLE----------AQLKKAHNIEDDSRMNPEFADQIKQL 708
Query: 467 D-----FGDKINSLQLEVEELTRQRNQLELELKQEKERRLQNDRSIPGRGSQKSESKMDG 521
D + D+ Q EV+ L ++E E K +K++++ S+ R + K+
Sbjct: 709 DKEASYYRDECGKAQAEVDRLLEILKEVENE-KNDKDKKIAELESLTLRHMKDQNKKVAN 767
Query: 522 -KHKMQEENVKLKKPLEESHRLQPHPMDEQDQLLLSEKPQLCQLCQEDGSLTK 573
KH Q E K + LEE R + D L + E + +++ TK
Sbjct: 768 LKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQIEELMNALEKTRQELDATK 820
Score = 58.9 bits (141), Expect = 1e-08
Identities = 85/351 (24%), Positives = 149/351 (42%), Gaps = 37/351 (10%)
Query: 240 MYLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEEL 299
M G SK E D + T + + + V++L+ +D EK N L EEL
Sbjct: 311 MLQSKGLPSKSLEDDNERTRRMAEAE----------SQVSHLEVILDQKEKENIHLREEL 360
Query: 300 AVANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKE----ETQL 355
+R LQ E + K + I + K +R + L + + LK T+
Sbjct: 361 ----HRRSQLQPEPAKTKALQTVIEMKDTKIASLERNI--RDLEDEIQMLKANGVLNTED 414
Query: 356 RLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDL-----------RAL 404
R + K++E+ S + M+ + L++++ +K+ L++L+ +L+ L L
Sbjct: 415 REEEIKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVL 474
Query: 405 KHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQRLRQAERSRQSAELDNRLF 464
K L K Q + + + L RLEEK + + KQL Q L + + + D +
Sbjct: 475 KESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQL-QDLTEEKGTLAGEIRDMKDM 533
Query: 465 KQDFGDKINSLQLEVEELTRQRNQLELELKQEKER--RLQNDRSIPGRGSQKSESKMDGK 522
+ KIN LQ ++E L Q + +L K+R LQ D S E + K
Sbjct: 534 LEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEK 593
Query: 523 HKMQEENVKLKKPLEESHRLQPHPMDEQDQLLLSEKPQLCQ--LCQEDGSL 571
++ E +K ++ ++ RL+ ++ L EK Q L +++ SL
Sbjct: 594 ERI-IERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSL 643
Score = 53.5 bits (127), Expect = 6e-07
Identities = 59/281 (20%), Positives = 116/281 (41%), Gaps = 12/281 (4%)
Query: 281 LQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQ 340
++ K+D L++ +K EL ++ TL + K+ + ES K+ R A Q
Sbjct: 432 MKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTA--KEQRAAILQ 489
Query: 341 A--------LSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALV 392
L E L ++T+ D+ +E ++M+ +++ E+ + Q +
Sbjct: 490 TEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIE 549
Query: 393 SLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQRLRQAER 452
+L++QL D L +++S + LEE ++ I++L+++ + +R
Sbjct: 550 NLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDR 609
Query: 453 SRQSAELDNRLFKQDFGDKINSLQLEVEELTRQRNQLELELKQEKERRLQNDRSIPGRGS 512
R R +D +K+N+LQ E+ E L+ L+ D +
Sbjct: 610 ERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSL-E 668
Query: 513 QKSESKMDGKHKMQEENVKLKKPLEESHRLQPHPMDEQDQL 553
E K + K+ E +K +E+ R+ P D+ QL
Sbjct: 669 IAIEQKKEECSKL-EAQLKKAHNIEDDSRMNPEFADQIKQL 708
Score = 40.8 bits (94), Expect = 0.004
Identities = 61/276 (22%), Positives = 123/276 (44%), Gaps = 53/276 (19%)
Query: 275 NATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQD 334
++T+ +LQA++ L++ N L +EL + +++ L M +K S L+ R
Sbjct: 144 DSTMLDLQAQLKELQRENDLLRKELDIKDSK---LGSSMNSIKTFWSPELKKERV----- 195
Query: 335 RTAEGQALSEARKHLKEETQLRLDVEKELEMQISMR--QEMELAMKMLEKDVCEKQDALV 392
L++E R+ V KE +M++S Q ++L ++ L+ ++ ++D L
Sbjct: 196 --------------LRKEEAARMSVLKE-QMRVSHEENQHLQLTIQALQDELRTQRD-LN 239
Query: 393 SLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQRLRQAER 452
L QQ R +H F ++ ++ ++ + R ++ + T++++E R+ E
Sbjct: 240 HLLQQESGNRGAEH---FTIELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRI---ET 293
Query: 453 SRQSAELDNRLFKQDFGDKINSLQLEVEELTRQRNQLELELKQEKERRLQNDRSIPGRGS 512
+Q+ + K+ + E+ + + L+ + ER R + S
Sbjct: 294 QKQTLNARDESIKK------------LLEMLQSKGLPSKSLEDDNERT----RRMAEAES 337
Query: 513 QKS--ESKMDGKHKMQEENVKLKKPLEESHRLQPHP 546
Q S E +D K K EN+ L++ L +LQP P
Sbjct: 338 QVSHLEVILDQKEK---ENIHLREELHRRSQLQPEP 370
Score = 36.6 bits (83), Expect = 0.071
Identities = 43/162 (26%), Positives = 77/162 (47%), Gaps = 29/162 (17%)
Query: 272 RHL---NATVNNLQAKVDALEKSNTKLTEEL-----AVANNRIITLQEEMERVKEESSYI 323
RH+ N V NL+ +K N +L EE+ ++A+N EE+ E++
Sbjct: 756 RHMKDQNKKVANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQIEELMNALEKTRQE 815
Query: 324 LESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELA------- 376
L++ K + Q+L+E HL LR++ K+LE + M+QE LA
Sbjct: 816 LDAT----KARLASTQQSLAEKEAHL---ANLRIERRKQLEEILEMKQEALLAAISEKDA 868
Query: 377 -MKMLEKDVCEK---QDALVSLRQQLDDLRALKHELAFKLQS 414
+ +LE +K Q+ +++L+++ D L H+L + Q+
Sbjct: 869 NIALLELSASKKKKTQEEVMALKREKD---RLVHQLKQQTQN 907
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 69.7 bits (169), Expect = 8e-12
Identities = 81/329 (24%), Positives = 142/329 (43%), Gaps = 40/329 (12%)
Query: 251 TEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQ 310
++ +G I D+K E +Q K D +++ L +EL A+NR+ L+
Sbjct: 1918 SKAEGVIDGYADEKTLFER----------QIQEKTDIIDR----LEQELLCASNRLQELE 1963
Query: 311 EEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMR 370
E ++++EE + + E Q L E K +KE+ +++ EK +R
Sbjct: 1964 AEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEK-------VR 2016
Query: 371 QEMELAMKMLEKDVCEKQDALVSLRQ----QLDDLRALKHELAFKLQSSDLGVKQKSELN 426
+++ +K LE DV E+ + L Q +L DLR L +L+ K E
Sbjct: 2017 DDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMR---KFLDEQA 2073
Query: 427 SRLEEKTNQMAATIKQLEQRLRQAERSRQSAELDNRLFKQ------DFGDKINSLQLEVE 480
E + + I++LEQ+L+ R + +E R +Q + DK + L L E
Sbjct: 2074 IDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKE 2133
Query: 481 ELTR--QRNQLELELKQEKERRLQNDRSIPGRGSQKSESKMDGKHKMQEENVKLKKPLEE 538
+L R Q E+E + + R L+ + QK E D KH E K + LE
Sbjct: 2134 QLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVE---DRKHFGAVE-AKPELSLEV 2189
Query: 539 SHRLQPHPMDEQDQLLLSEKPQLCQLCQE 567
+ + +D +++ + + + QL Q +E
Sbjct: 2190 QLQAERDAIDRKEKEITNLEEQLEQFREE 2218
Score = 59.7 bits (143), Expect = 8e-09
Identities = 88/387 (22%), Positives = 162/387 (41%), Gaps = 47/387 (12%)
Query: 225 KGEDLDSQVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVEELNRHL---NATVNNL 281
K ED Q+ + + + + K E + I +++ +EELN + L
Sbjct: 290 KKEDFTMQISFLQEKIKVYEMEQDKKVENSNK-EEIQEKETIIEELNTKIIEEEKKTLEL 348
Query: 282 QAKVDALEKSNTKLTEELAVANNRI------ITLQEEMERVKEESSYILESNRKGPKQDR 335
+ K+ +K +L E++ N I +T ++ ER E L + ++
Sbjct: 349 KDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRN 408
Query: 336 TAEGQALSEARKHLKEETQLRLD-VEKELE----------MQISMRQEMELAMKMLEKDV 384
+ Q ++ + +++ETQ +L+ + EL+ Q +RQ M +M +
Sbjct: 409 HKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHK 468
Query: 385 CEKQDALVSL------RQQLDDLRALKHELAFKLQSSDLGV-KQKSELNSRLEEKT---N 434
E ++AL S Q+ + +EL KLQ ++ K K EL LEEK
Sbjct: 469 GEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQR 528
Query: 435 QMAATIKQLEQRLRQAERSRQS-AELDNRLFKQDFG-DKINSLQLEVEELTRQRNQLELE 492
Q+ +++L Q +R+RQ+ AE +++L + + L+ E+ + R +LEL+
Sbjct: 529 QLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELK 588
Query: 493 LKQE------------KERRLQNDRSIPGRGSQKSESKMDGKHKMQEENVKLKKPLEESH 540
+ E KE+ DR + ++ + +EE KLK+ LE H
Sbjct: 589 HEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEH 648
Query: 541 RLQPHPMDEQDQLLLSEKPQLCQLCQE 567
R+ + +D L + K Q+ L E
Sbjct: 649 RINIEKL--KDNLGIHYKQQIDGLQNE 673
Score = 58.2 bits (139), Expect = 2e-08
Identities = 78/333 (23%), Positives = 142/333 (42%), Gaps = 37/333 (11%)
Query: 248 SKGTEGDGQITAILDQKNY----VEELNRHLNATVNN-LQAKVDALEKSNTKLTEELAVA 302
SK TE +++ L + + ++ N L +++ LQA V+ L ++ ++ + +L A
Sbjct: 1812 SKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHA 1871
Query: 303 NNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKE 362
L E R K+E++ L+ E R+ L EE++ R + E
Sbjct: 1872 KVTQTELMRESFRQKQEATESLKCQE---------------ELRERLHEESRAREQLAVE 1916
Query: 363 LEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQK 422
L + + E+ + EK D + L Q+L EL + Q ++++
Sbjct: 1917 LSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQ----IQEE 1972
Query: 423 SELNSRLEEKTNQMAATI-KQLEQRLRQAERSRQSAELDNRLFKQDFGDKINSLQLEVEE 481
EL SR +E A + +QL Q + + + + + D ++ +L+++VEE
Sbjct: 1973 RELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEE 2032
Query: 482 LTRQRNQLELELKQE-KERRLQN---DRSIPGRGSQKSESKMDGKHK---MQEENVKLKK 534
+ +LE E E + R QN ++ + E +D +H+ Q+E KL++
Sbjct: 2033 QVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQ 2092
Query: 535 PLEESHRLQP---HPMDEQDQLL--LSEKPQLC 562
L+ R QP H E +QL L EK C
Sbjct: 2093 QLKVVPRFQPISEHQTREVEQLANHLKEKTDKC 2125
Score = 52.8 bits (125), Expect = 1e-06
Identities = 80/377 (21%), Positives = 165/377 (43%), Gaps = 55/377 (14%)
Query: 224 MKGEDLDSQVGVIDFSMYLKDGNSSKGTEG--------------DG---QITAILDQ--- 263
M+ E Q + + + L++ + GTEG DG Q+TA L Q
Sbjct: 160 MESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARR 219
Query: 264 ------KNYVE--ELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMER 315
+ ++E E ++ L LQA +++ +L A +I+T Q+++
Sbjct: 220 EKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQL-- 277
Query: 316 VKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMEL 375
EE ++LE +K K+D T + L E K + E +++ + E+ QE E
Sbjct: 278 --EEQDHLLEDYQK-KKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEI-----QEKET 329
Query: 376 AMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQ 435
++ L + E++ + L+ +L L EL ++ + +K + ++K Q
Sbjct: 330 IIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQ 389
Query: 436 MAATIKQL-----EQRLRQAERSRQSAELDNRLFKQDFGDKINSLQLEVEELTRQR-NQL 489
+ IKQL E + R + S+ ++ R+ +Q+ K+ L+ E++E+ Q+ Q+
Sbjct: 390 SSEEIKQLMGTVEELQKRNHKDSQFETDIVQRM-EQETQRKLEQLRAELDEMYGQQIVQM 448
Query: 490 ELELKQEKERRLQNDRSIPGRGSQKSESKMDGKHKMQEENVKLKK--------PLEESHR 541
+ EL ++ +++ + +G ++ + + E+ +KL L++++
Sbjct: 449 KQELIRQHMAQME-EMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNS 507
Query: 542 LQPHPMDEQDQLLLSEK 558
Q + E+ L+L EK
Sbjct: 508 -QKEKLKEELGLILEEK 523
Score = 49.3 bits (116), Expect = 1e-05
Identities = 78/351 (22%), Positives = 142/351 (40%), Gaps = 73/351 (20%)
Query: 268 EELNRHLNATVNNLQAKVDALEKSNTKLTEELAVA-------NNRIITLQEEMERVKEES 320
++ +R L + +AK+ E+ + + E+L + N ++ L E+ +++ ES
Sbjct: 3214 QKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNES 3273
Query: 321 SYILESNRK------GPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQ--- 371
+ES R +Q R E Q L E+ K E LD E+EL Q+
Sbjct: 3274 QQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTG 3333
Query: 372 ------EMELAMKMLEKDVCEKQDALVSL--------------RQQLD-DLRALKHELAF 410
E +K L+K + EK +V L RQQ++ D + + L
Sbjct: 3334 QSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQT 3393
Query: 411 KLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFGD 470
+ +++ G K+ EL S++E+ L+++L + + +L+ + Q
Sbjct: 3394 EQEANTEGQKKMHELQSKVED-----------LQRQLEEKRQQVYKLDLEGQRL-QGIMQ 3441
Query: 471 KINSLQLEVEELTRQRNQLELELKQEKERRLQNDRS--------IPGRGSQKSESK---M 519
+ +LE EE R L L + L +DR+ I G + + +K M
Sbjct: 3442 EFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEM 3501
Query: 520 DG-----KHKMQEENVKLK--------KPLEESHRLQPHPMDEQDQLLLSE 557
+G H+++ KL+ P + S RLQ D++D + + E
Sbjct: 3502 NGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQE 3552
Score = 47.8 bits (112), Expect = 3e-05
Identities = 55/246 (22%), Positives = 112/246 (45%), Gaps = 19/246 (7%)
Query: 256 QITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMER 315
+IT + +Q E + N V L +++ +K +T +EL N +++ME+
Sbjct: 2204 EITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENK---LFKDDMEK 2260
Query: 316 ----VKE------ESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEM 365
+KE + ++L Q++ E L+E L+++ ++ D K +E
Sbjct: 2261 LGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTD-NKVIEE 2319
Query: 366 QISMRQEMELAMKMLEKDV-CEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSE 424
+ + +++E ++ L D C K++ + Q + + L+ ELA Q + + SE
Sbjct: 2320 KNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSE 2379
Query: 425 LNSRLEEKTNQMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFGDKINSLQLEVEELTR 484
L+ + + + A LEQ++ A + + + N L + +F K+N L E+ L R
Sbjct: 2380 EADSLKHQLDVVIAEKLALEQQVETA--NEEMTFMKNVLKETNF--KMNQLTQELFSLKR 2435
Query: 485 QRNQLE 490
+R +E
Sbjct: 2436 ERESVE 2441
Score = 47.4 bits (111), Expect = 4e-05
Identities = 67/332 (20%), Positives = 140/332 (42%), Gaps = 52/332 (15%)
Query: 269 ELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNR 328
EL + N + +L+ + ALEK K+ + L + + I + E + ++E + + +
Sbjct: 2039 ELEQEKNTELMDLRQQNQALEKQLEKMRKFL---DEQAIDREHERDVFQQEIQKLEQQLK 2095
Query: 329 KGPKQDRTAEGQA--LSEARKHLKEETQLRLDV---EKELEMQISMRQEMELAMKMLEKD 383
P+ +E Q + + HLKE+T ++ +++L+ I R E ++ LE
Sbjct: 2096 VVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNE---EIEKLEFR 2152
Query: 384 VCEKQDALVSLRQQLDDLRALKH----------ELAFKLQSSDLGVKQKSELNSRLEEKT 433
V E + AL+ + KH L +LQ+ + +K + + LEE+
Sbjct: 2153 VRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQL 2212
Query: 434 NQMAATIK-----------QLEQRLRQAERSRQSAELDNRLFKQDFGDKINSLQLEVEEL 482
Q ++ QLE + +++ Q E +N+LFK D
Sbjct: 2213 EQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDM-------------- 2258
Query: 483 TRQRNQLELELKQEKERRLQNDRSIPGRGSQKSESKMDGKHKMQEENVKLKKPLEESHRL 542
+L L +K+ Q+ + G+ +Q + K ++ E+ KL++ L+ +
Sbjct: 2259 ----EKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKIT--T 2312
Query: 543 QPHPMDEQDQLLLSEKPQLCQLCQEDGSLTKN 574
++E+++L+ + Q+ L + + +N
Sbjct: 2313 DNKVIEEKNELIRDLETQIECLMSDQECVKRN 2344
Score = 46.6 bits (109), Expect = 7e-05
Identities = 53/235 (22%), Positives = 105/235 (44%), Gaps = 35/235 (14%)
Query: 333 QDRTAEGQALSEA-----RKHLKEETQLRLDVEKELEMQISMRQEMEL-AMKMLEKDVCE 386
Q++ E QA E R+ L E Q ++ + QE E + ++LE ++ +
Sbjct: 3069 QEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQ 3128
Query: 387 KQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQR 446
KQ ++ ++ +L ++ EL +L S + V +EL S L + ++ T+K +
Sbjct: 3129 KQSQMLEMQVELSSMKDRATELQEQLSSEKMVV---AELKSELAQTKLELETTLKAQHKH 3185
Query: 447 LRQAERSRQSAELDNRLFKQDFGDKINSLQLEVEEL-TRQRNQLELELKQEKERRLQNDR 505
L++ E F+ + DK + + L + L + Q+ EL+ EKE +
Sbjct: 3186 LKELE-----------AFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKE------K 3228
Query: 506 SIPGRGSQKSESKMDGKHKMQEENVKLKKPLEESHRLQPHPMDEQDQLLLSEKPQ 560
+ GR ++ + ++ E++K ++ LQ + + EQ + LL+E Q
Sbjct: 3229 AKLGRSEERDKEEL--------EDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQ 3275
Score = 45.1 bits (105), Expect = 2e-04
Identities = 64/297 (21%), Positives = 127/297 (42%), Gaps = 33/297 (11%)
Query: 270 LNRH-LNATVNNLQAKVD-------ALEKSNTKLTEELAVANNRIITLQEEMERVKEESS 321
+N H L+ ++L+ ++D ALE+ EE+ N + +M ++ +E
Sbjct: 2372 MNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQEL- 2430
Query: 322 YILESNRKGPKQDRTAEGQALSEARKHLKE-----ETQLRLDVEKELEMQISMRQ----- 371
+ L+ R+ ++ ++ +++ A HL + E L D K LE Q +
Sbjct: 2431 FSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENG 2490
Query: 372 -----EMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSE-- 424
+E + LE V K L +Q+ D++ LQ + +++ E
Sbjct: 2491 KGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEK 2550
Query: 425 ----LNSRLEEKTNQMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFGDKINSLQLEVE 480
L S+++ + Q A Q Q + +E R + + N+L + + G I++L L +
Sbjct: 2551 VAAALVSQIQLEAVQEYAKFCQDNQTI-SSEPERTNIQNLNQLREDELGSDISALTLRIS 2609
Query: 481 ELTRQRNQLELELKQEKERRLQNDRSIPGRGSQKSESK--MDGKHKMQEENVKLKKP 535
EL Q ++ L EKE+ ++++ + + E + ++G K Q E K + P
Sbjct: 2610 ELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSP 2666
Score = 39.3 bits (90), Expect = 0.011
Identities = 70/357 (19%), Positives = 148/357 (41%), Gaps = 56/357 (15%)
Query: 261 LDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEES 320
++ + +E+L +L + + ++D L+ ++ E + + +IT Q ++ +
Sbjct: 646 IEHRINIEKLKDNLGI---HYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKL 702
Query: 321 SYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKML 380
+ +S ++ T + L + + L++E + + +E+E++ + +E MK
Sbjct: 703 KDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEK 762
Query: 381 EKDVCEK-------QDALVSLRQQLDDLRAL------KHELAF----KLQSSDLGVKQKS 423
E D+ EK L ++ L+D+ + + L F K +S D +++
Sbjct: 763 ENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEI 822
Query: 424 ELNSRLEEKTNQMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFGDKINSLQLEVEELT 483
E+ L E+ + QL + + + + AE + + Q+ ++ L ++L
Sbjct: 823 EI---LIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLE 879
Query: 484 RQRNQLELELKQE-----KERRLQ--NDRSIPGRGSQKSESK--------------MDGK 522
+N+ ELE K + +E LQ N ++ + S E K D
Sbjct: 880 DSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTT 939
Query: 523 HKMQEENVKLKKPLEESHRL--------QPHP----MDEQDQLLLSEKPQLCQLCQE 567
M++ V ++ LE S RL Q H ++E+ + L EK Q+ C+E
Sbjct: 940 ELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRE 996
Score = 35.4 bits (80), Expect = 0.16
Identities = 62/319 (19%), Positives = 129/319 (40%), Gaps = 53/319 (16%)
Query: 261 LDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEE-------- 312
L+ + Y + + ++ NL+ ++ LE + + EL +I +QE+
Sbjct: 2477 LENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEML 2536
Query: 313 ------MERVKEE-------SSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLD- 358
++++ EE S LE+ ++ K + + + R +++ QLR D
Sbjct: 2537 QKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDE 2596
Query: 359 ---------------VEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRA 403
+ +EM S+ E E +++ EK+V EK+ L+ L++ L+
Sbjct: 2597 LGSDISALTLRISELESQVVEMHTSLILEKE-QVEIAEKNVLEKEKKLLELQKLLEGNEK 2655
Query: 404 LKHELAFKLQSSDLGV----------KQKSELNSRLEEKTNQMAATIKQLEQRLRQAERS 453
+ E K D+ V ++S + LE + AT +L +AE+
Sbjct: 2656 KQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKL 2715
Query: 454 RQS---AELDNRLFKQDFGDKINSLQLEVEELTRQRNQLELELKQEKERRLQNDRSIPGR 510
++ E + ++D + L E+L+ + E E+++ K+ + +P +
Sbjct: 2716 QEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACM--FEPLPIK 2773
Query: 511 GSQKSESKMDGKHKMQEEN 529
S+ S+ DG K+ N
Sbjct: 2774 LSKSIASQTDGTLKISSSN 2792
Score = 34.3 bits (77), Expect = 0.35
Identities = 68/310 (21%), Positives = 126/310 (40%), Gaps = 53/310 (17%)
Query: 167 LRLALMQKKLSEYMKALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKG 226
LR++ ++ ++ E +LI +KE + E E N L E++ + LL G K
Sbjct: 2606 LRISELESQVVEMHTSLILEKEQV-EIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKR 2664
Query: 227 EDLDSQVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVD 286
D V V+ + L N G N +E L AT +A++
Sbjct: 2665 SPQD--VEVLKTTTELFHSNEESGFF------------NELEALRAESVAT----KAELA 2706
Query: 287 ALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEAR 346
+ ++ KL EEL V + +LQ+++ +V++ L+EA+
Sbjct: 2707 SYKEKAEKLQEELLVKETNMTSLQKDLSQVRDH----------------------LAEAK 2744
Query: 347 KHLKEETQLRLDVEKELEMQISMRQEM-ELAMKMLEKDVCEKQDALVSLRQQLDDLRALK 405
+ L L+ E E E+Q S + M E L K + + D + + + L
Sbjct: 2745 EKLS-----ILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILV 2799
Query: 406 HELAFKLQ-SSDLGVKQKSELNSRLEEKTNQM----AATIKQLEQR-LRQAERSRQSAEL 459
++ S+ ++ +E+ S+ EK +M AA I +E R + + E ++ +
Sbjct: 2800 KNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYV 2859
Query: 460 DNRLFKQDFG 469
+L K++ G
Sbjct: 2860 AVQLLKEECG 2869
Score = 33.1 bits (74), Expect = 0.78
Identities = 31/150 (20%), Positives = 67/150 (44%), Gaps = 23/150 (15%)
Query: 317 KEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISM---RQEM 373
KE S + N QD E Q E L + + L+ ++S +Q
Sbjct: 1227 KENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTD 1286
Query: 374 ELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNS------ 427
+ ++ E+++ +++ +S+ Q+ +L D+ V KS+L+S
Sbjct: 1287 GMKLEFGEENLPKEETEFLSIHSQMTNLE-------------DIDVNHKSKLSSLQDLEK 1333
Query: 428 -RLEEKTNQMAATIKQLEQRLRQAERSRQS 456
+LEE+ ++ + I L+Q+L++ E++ ++
Sbjct: 1334 TKLEEQVQELESLISSLQQQLKETEQNYEA 1363
Score = 32.7 bits (73), Expect = 1.0
Identities = 94/458 (20%), Positives = 172/458 (37%), Gaps = 75/458 (16%)
Query: 171 LMQKKLSEYMKALINKKELLS-----------EFYEPNALMMEEEGAIIAGLLVGLNVID 219
L+ K EY K L+ + L EF E N E E I + L ID
Sbjct: 1259 LLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDID 1318
Query: 220 ANFCMKGEDLDSQVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVN 279
N K L S L+D +K E + + ++ + L + L T
Sbjct: 1319 VNHKSK---LSS----------LQDLEKTKLEE------QVQELESLISSLQQQLKETEQ 1359
Query: 280 NLQAKVDALEKSNTKLTEELAVAN---NRIITLQEEMERVKEESSYILE--------SNR 328
N +A++ L+K ++E + + ++ + + +R S + + S
Sbjct: 1360 NYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGE 1419
Query: 329 KGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKD----- 383
G K++ + ++ L+EE + + M I+ Q+ EL+ K+
Sbjct: 1420 FGVKEETNIVKLLEKQYQEQLEEEVAKVI-----VSMSIAFAQQTELSRISGGKENTASS 1474
Query: 384 -----VCEKQDAL---VSLRQ-----QLDDLRALKHELAFKLQSSDLGVKQKSELNSRLE 430
VC+++ + L Q Q + +K + FK S +LG K L S +
Sbjct: 1475 KQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSD 1534
Query: 431 E----KTNQMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFGDKI--NSLQLEV--EEL 482
++ TI + + RQS + + D ++ N QLE +EL
Sbjct: 1535 PHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQEL 1594
Query: 483 TRQ--RNQLELELKQEKERRLQNDRSIPGRGSQKSESKMDGKHKMQEENVKLKKPLEESH 540
RQ +Q EL ++ R Q +R + + E K + Q ++ + + E
Sbjct: 1595 VRQYQEHQQATELLRQAHMR-QMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERE 1653
Query: 541 RLQPHPMDEQDQLLLSEKPQLCQLCQEDGSLTKNVCKN 578
R+ ++ QL L+ + +LC + + T+N +N
Sbjct: 1654 RVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNEN 1691
Score = 31.6 bits (70), Expect = 2.3
Identities = 42/209 (20%), Positives = 84/209 (40%), Gaps = 29/209 (13%)
Query: 256 QITAILDQ-KNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEME 314
Q+ +L+Q K + E + + + A++ + N +L L RI + ++
Sbjct: 3258 QLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLD 3317
Query: 315 RVKEESSYILESNRKG------PKQDRTAEGQA------------LSEARKHLKEETQLR 356
R +E + + S+ G P +D E Q L+E K+ + Q R
Sbjct: 3318 RERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTR 3377
Query: 357 LDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAF------ 410
+EK+ ++ Q + A +K + E Q + L++QL++ R ++L
Sbjct: 3378 QQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQ 3437
Query: 411 ----KLQSSDLGVKQKSELNSRLEEKTNQ 435
+ Q +L ++K E L + N+
Sbjct: 3438 GIMQEFQKQELEREEKRESRRILYQNLNE 3466
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 69.3 bits (168), Expect = 1e-11
Identities = 93/449 (20%), Positives = 191/449 (42%), Gaps = 45/449 (10%)
Query: 136 VEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALINKKELLSEFYE 195
V++L EA ++ + + D K +A +A +KK Y++ L +++ LS
Sbjct: 141 VKQLEGEARDLISRLHD--SWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELY 198
Query: 196 PNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKDGNSSKGTEGDG 255
N + EE A L L ++++ E + Q+ V + L+ +K
Sbjct: 199 RNTITDEELKEKNAKLQEKLQLVES------EKSEIQLNVKELKRKLE---RAKLLLPQQ 249
Query: 256 QITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMER 315
Q+ A D L + L + LQA+V+ E N ++ + +QE E+
Sbjct: 250 QLQAEADH------LGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEK 303
Query: 316 VKEESSYILESNRKGPKQDRTA----------------EGQALSEARKHLKEETQLRLDV 359
++E+ I E K +Q+ + + + E + + E+ ++R
Sbjct: 304 IQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQE 363
Query: 360 EKELE----MQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSS 415
EK E + RQE E M E+ + E+++ + + + + E K+
Sbjct: 364 EKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQ 423
Query: 416 DLGVKQKSELNSRLEEKTNQMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFGDKINSL 475
+ ++++ E R EEK + I++ E+++R+ E Q E + ++ +
Sbjct: 424 EEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKM 483
Query: 476 QLEVEELTRQRNQLELELK--QEKERRLQNDRSIPGRGSQKSESKM-DGKHKMQEENVKL 532
Q + E++ RQ ++ + K +E+E +++ + Q+ E KM + + KM E+ K+
Sbjct: 484 QEQEEKMRRQEEKIREQEKKIREQEEKIREQEEM----MQEQEEKMWEQEEKMCEQEEKM 539
Query: 533 KKPLEESHRLQPHPMDEQDQLLLSEKPQL 561
++ EE R Q M EQ+ L ++ ++
Sbjct: 540 QEQ-EEKMRRQEEKMREQEVRLRQQEEKM 567
Score = 64.3 bits (155), Expect = 3e-10
Identities = 71/333 (21%), Positives = 155/333 (46%), Gaps = 35/333 (10%)
Query: 257 ITAILDQKN----YVEELNRHLNATVNNLQAKV---DALEKSNTKLTEELAVANNRIITL 309
++A+ QK Y+EEL + +A L + L++ N KL E+L + + +
Sbjct: 169 LSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEI 228
Query: 310 Q---EEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQ 366
Q +E++R E + +L P+Q AE L + + + + Q +++ E E+
Sbjct: 229 QLNVKELKRKLERAKLLL------PQQQLQAEADHLGKELQSVSAKLQAQVE---ENELW 279
Query: 367 ISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELN 426
+ Q+ E M E+ + E+++ +++Q + +R E K++ + + +K E
Sbjct: 280 NRLNQQQEEKMWRQEEKIQEREE---KIQEQEEKIR----EQEEKMRRQEEMMWEKEEKM 332
Query: 427 SRLEEKTNQMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFGDKINSLQLEVEELTRQ- 485
R EE + I++LE+++ + E+ R+ E K+ +KI + E+ +
Sbjct: 333 RRQEEMMWEKEEKIRELEEKMHEQEKIREQEE------KRQEEEKIREQEKRQEQEAKMW 386
Query: 486 RNQLELELKQEKERRLQNDRSIPGRGSQKSESKM-DGKHKMQEENVKLKKPLEESHRLQP 544
R + ++ ++EK R + + E KM + + +MQE+ K+++ EE R Q
Sbjct: 387 RQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQ-EEKIREQE 445
Query: 545 HPMDEQDQLLLSEKPQLCQLCQEDGSLTKNVCK 577
+ EQ++ + ++ + + ++ G +C+
Sbjct: 446 KKIREQEEKIREQEEMMQEQEEKMGEQEGKMCE 478
Score = 45.8 bits (107), Expect = 1e-04
Identities = 35/178 (19%), Positives = 81/178 (45%), Gaps = 1/178 (0%)
Query: 278 VNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQDRTA 337
+ + K+ E+ + E++ ++ +EEM+ +E+ E R+ K+ R
Sbjct: 392 IREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQ 451
Query: 338 EGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQ 397
E + + E + ++E+ + + E ++ Q + QE E M+ E+ + E++ + ++
Sbjct: 452 E-EKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEK 510
Query: 398 LDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQRLRQAERSRQ 455
+ + + E K+ + + ++ E EEK + +++ E RLRQ E Q
Sbjct: 511 IREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEKMQ 568
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.129 0.358
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,681,797
Number of Sequences: 37866
Number of extensions: 1044655
Number of successful extensions: 10204
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 329
Number of HSP's successfully gapped in prelim test: 947
Number of HSP's that attempted gapping in prelim test: 4964
Number of HSP's gapped (non-prelim): 3568
length of query: 620
length of database: 18,247,518
effective HSP length: 108
effective length of query: 512
effective length of database: 14,157,990
effective search space: 7248890880
effective search space used: 7248890880
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.