Search of human proteins with 82546843

Search of human proteins with 82546843

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens]
         (1271 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens]       2544   0.0  
gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens]       2434   0.0  
gi|38679957 active breakpoint cluster region-related  protein is...  1136   0.0  
gi|229094128 active breakpoint cluster region-related  protein i...  1134   0.0  
gi|38679954 active breakpoint cluster region-related  protein is...  1112   0.0  
gi|239746665 PREDICTED: hypothetical protein XP_002343826 [Homo ...   174   5e-43
gi|239757684 PREDICTED: hypothetical protein [Homo sapiens]           169   1e-41
gi|239752174 PREDICTED: hypothetical protein XP_002348160 [Homo ...   169   1e-41
gi|239746697 PREDICTED: hypothetical protein XP_002343833 [Homo ...   169   1e-41
gi|226693398 Rho GTPase activating protein 27 isoform b [Homo sa...   138   4e-32
gi|40548322 Rho GTPase activating protein 27 isoform a [Homo sap...   138   4e-32
gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17 [Hom...   134   6e-31
gi|149274655 synapse defective 1, Rho GTPase, homolog 2 [Homo sa...   133   1e-30
gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens]            129   1e-29
gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens]          129   1e-29
gi|188497642 ARHGAP15 [Homo sapiens]                                  125   3e-28
gi|42475970 synapse defective 1, Rho GTPase, homolog 1 [Homo sap...   121   5e-27
gi|26986534 Rho GTPase activating protein 12 [Homo sapiens]           119   2e-26
gi|203097003 Rho GTPase activating protein 21 [Homo sapiens]          118   3e-26
gi|4757980 beta chimerin isoform 2 [Homo sapiens]                     117   7e-26
gi|91106928 beta chimerin isoform 1 [Homo sapiens]                    117   7e-26
gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]          112   2e-24
gi|62548864 Rho guanine nucleotide exchange factor 10 [Homo sapi...   110   1e-23
gi|122939147 Rho GTPase activating protein 9 isoform 1 [Homo sap...   109   1e-23
gi|122939149 Rho GTPase activating protein 9 isoform 3 [Homo sap...   109   1e-23
gi|47834348 minor histocompatibility antigen HA-1 [Homo sapiens]      108   4e-23
gi|5803145 ralA binding protein 1 [Homo sapiens]                      107   7e-23
gi|58761492 Rho guanine nucleotide exchange factor (GEF) 10-like...   105   4e-22
gi|74136547 Rho guanine nucleotide exchange factor (GEF) 10-like...   105   4e-22
gi|150417981 glucocorticoid receptor DNA binding factor 1 [Homo ...   103   1e-21

>gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens]
          Length = 1271

 Score = 2544 bits (6594), Expect = 0.0
 Identities = 1271/1271 (100%), Positives = 1271/1271 (100%)

Query: 1    MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQ 60
            MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQ
Sbjct: 1    MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQ 60

Query: 61   TLLAKEKKSYDRQRWGFRRAAQAPDGASEPRASASRPQPAPADGADPPPAEEPEARPDGE 120
            TLLAKEKKSYDRQRWGFRRAAQAPDGASEPRASASRPQPAPADGADPPPAEEPEARPDGE
Sbjct: 61   TLLAKEKKSYDRQRWGFRRAAQAPDGASEPRASASRPQPAPADGADPPPAEEPEARPDGE 120

Query: 121  GSPGKARPGTARRPGAAASGERDDRGPPASVAALRSNFERIRKGHGQPGADAEKPFYVNV 180
            GSPGKARPGTARRPGAAASGERDDRGPPASVAALRSNFERIRKGHGQPGADAEKPFYVNV
Sbjct: 121  GSPGKARPGTARRPGAAASGERDDRGPPASVAALRSNFERIRKGHGQPGADAEKPFYVNV 180

Query: 181  EFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSC 240
            EFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSC
Sbjct: 181  EFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSC 240

Query: 241  GVDGDYEDAELNPRFLKDNLIDANGGSRPPWPPLEYQPYQSIYVGGMMEGEGKGPLLRSQ 300
            GVDGDYEDAELNPRFLKDNLIDANGGSRPPWPPLEYQPYQSIYVGGMMEGEGKGPLLRSQ
Sbjct: 241  GVDGDYEDAELNPRFLKDNLIDANGGSRPPWPPLEYQPYQSIYVGGMMEGEGKGPLLRSQ 300

Query: 301  STSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTY 360
            STSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTY
Sbjct: 301  STSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTY 360

Query: 361  RMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVSEATIVGVRKTGQIWPNDGEG 420
            RMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVSEATIVGVRKTGQIWPNDGEG
Sbjct: 361  RMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVSEATIVGVRKTGQIWPNDGEG 420

Query: 421  AFHGDADGSFGTPPGYGCAADRAEEQRRHQDGLPYIDDSPSSSPHLSSKGRGSRDALVSG 480
            AFHGDADGSFGTPPGYGCAADRAEEQRRHQDGLPYIDDSPSSSPHLSSKGRGSRDALVSG
Sbjct: 421  AFHGDADGSFGTPPGYGCAADRAEEQRRHQDGLPYIDDSPSSSPHLSSKGRGSRDALVSG 480

Query: 481  ALESTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTS 540
            ALESTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTS
Sbjct: 481  ALESTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTS 540

Query: 541  QQIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGV 600
            QQIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGV
Sbjct: 541  QQIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGV 600

Query: 601  AMEMAEKCCQANAQFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLHDL 660
            AMEMAEKCCQANAQFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLHDL
Sbjct: 601  AMEMAEKCCQANAQFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLHDL 660

Query: 661  LKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGEHRQLLKDSFMVELVE 720
            LKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGEHRQLLKDSFMVELVE
Sbjct: 661  LKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGEHRQLLKDSFMVELVE 720

Query: 721  GARKLRHVFLFTDLLLCTKLKKQSGGKTQQYDCKWYIPLTDLSFQMVDELEAVPNIPLVP 780
            GARKLRHVFLFTDLLLCTKLKKQSGGKTQQYDCKWYIPLTDLSFQMVDELEAVPNIPLVP
Sbjct: 721  GARKLRHVFLFTDLLLCTKLKKQSGGKTQQYDCKWYIPLTDLSFQMVDELEAVPNIPLVP 780

Query: 781  DEELDALKIKISQIKNDIQREKRANKGSKATERLKKKLSEQESLLLLMSPSMAFRVHSRN 840
            DEELDALKIKISQIKNDIQREKRANKGSKATERLKKKLSEQESLLLLMSPSMAFRVHSRN
Sbjct: 781  DEELDALKIKISQIKNDIQREKRANKGSKATERLKKKLSEQESLLLLMSPSMAFRVHSRN 840

Query: 841  GKSYTFLISSDYERAEWRENIREQQKKCFRSFSLTSVELQMLTNSCVKLQTVHSIPLTIN 900
            GKSYTFLISSDYERAEWRENIREQQKKCFRSFSLTSVELQMLTNSCVKLQTVHSIPLTIN
Sbjct: 841  GKSYTFLISSDYERAEWRENIREQQKKCFRSFSLTSVELQMLTNSCVKLQTVHSIPLTIN 900

Query: 901  KEDDESPGLYGFLNVIVHSATGFKQSSNLYCTLEVDSFGYFVNKAKTRVYRDTAEPNWNE 960
            KEDDESPGLYGFLNVIVHSATGFKQSSNLYCTLEVDSFGYFVNKAKTRVYRDTAEPNWNE
Sbjct: 901  KEDDESPGLYGFLNVIVHSATGFKQSSNLYCTLEVDSFGYFVNKAKTRVYRDTAEPNWNE 960

Query: 961  EFEIELEGSQTLRILCYEKCYNKTKIPKEDGESTDRLMGKGQVQLDPQALQDRDWQRTVI 1020
            EFEIELEGSQTLRILCYEKCYNKTKIPKEDGESTDRLMGKGQVQLDPQALQDRDWQRTVI
Sbjct: 961  EFEIELEGSQTLRILCYEKCYNKTKIPKEDGESTDRLMGKGQVQLDPQALQDRDWQRTVI 1020

Query: 1021 AMNGIEVKLSVKFNSREFSLKRMPSRKQTGVFGVKIAVVTKRERSKVPYIVRQCVEEIER 1080
            AMNGIEVKLSVKFNSREFSLKRMPSRKQTGVFGVKIAVVTKRERSKVPYIVRQCVEEIER
Sbjct: 1021 AMNGIEVKLSVKFNSREFSLKRMPSRKQTGVFGVKIAVVTKRERSKVPYIVRQCVEEIER 1080

Query: 1081 RGMEEVGIYRVSGVATDIQALKAAFDVNNKDVSVMMSEMDVNAIAGTLKLYFRELPEPLF 1140
            RGMEEVGIYRVSGVATDIQALKAAFDVNNKDVSVMMSEMDVNAIAGTLKLYFRELPEPLF
Sbjct: 1081 RGMEEVGIYRVSGVATDIQALKAAFDVNNKDVSVMMSEMDVNAIAGTLKLYFRELPEPLF 1140

Query: 1141 TDEFYPNFAEGIALSDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSL 1200
            TDEFYPNFAEGIALSDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSL
Sbjct: 1141 TDEFYPNFAEGIALSDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSL 1200

Query: 1201 HNLATVFGPTLLRPSEKESKLPANPSQPITMTDSWSLEVMSQVQVLLYFLQLEAIPAPDS 1260
            HNLATVFGPTLLRPSEKESKLPANPSQPITMTDSWSLEVMSQVQVLLYFLQLEAIPAPDS
Sbjct: 1201 HNLATVFGPTLLRPSEKESKLPANPSQPITMTDSWSLEVMSQVQVLLYFLQLEAIPAPDS 1260

Query: 1261 KRQSILFSTEV 1271
            KRQSILFSTEV
Sbjct: 1261 KRQSILFSTEV 1271


>gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens]
          Length = 1227

 Score = 2434 bits (6307), Expect = 0.0
 Identities = 1227/1271 (96%), Positives = 1227/1271 (96%), Gaps = 44/1271 (3%)

Query: 1    MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQ 60
            MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQ
Sbjct: 1    MVDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQ 60

Query: 61   TLLAKEKKSYDRQRWGFRRAAQAPDGASEPRASASRPQPAPADGADPPPAEEPEARPDGE 120
            TLLAKEKKSYDRQRWGFRRAAQAPDGASEPRASASRPQPAPADGADPPPAEEPEARPDGE
Sbjct: 61   TLLAKEKKSYDRQRWGFRRAAQAPDGASEPRASASRPQPAPADGADPPPAEEPEARPDGE 120

Query: 121  GSPGKARPGTARRPGAAASGERDDRGPPASVAALRSNFERIRKGHGQPGADAEKPFYVNV 180
            GSPGKARPGTARRPGAAASGERDDRGPPASVAALRSNFERIRKGHGQPGADAEKPFYVNV
Sbjct: 121  GSPGKARPGTARRPGAAASGERDDRGPPASVAALRSNFERIRKGHGQPGADAEKPFYVNV 180

Query: 181  EFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSC 240
            EFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSC
Sbjct: 181  EFHHERGLVKVNDKEVSDRISSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSC 240

Query: 241  GVDGDYEDAELNPRFLKDNLIDANGGSRPPWPPLEYQPYQSIYVGGMMEGEGKGPLLRSQ 300
            GVDGDYEDAELNPRFLKDNLIDANGGSRPPWPPLEYQPYQSIYVGGMMEGEGKGPLLRSQ
Sbjct: 241  GVDGDYEDAELNPRFLKDNLIDANGGSRPPWPPLEYQPYQSIYVGGMMEGEGKGPLLRSQ 300

Query: 301  STSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTY 360
            STSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTY
Sbjct: 301  STSEQEKRLTWPRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTY 360

Query: 361  RMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVSEATIVGVRKTGQIWPNDGEG 420
            RMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVSEATIVGVRKTGQIWPNDGEG
Sbjct: 361  RMFRDKSRSPSQNSQQSFDSSSPPTPQCHKRHRHCPVVVSEATIVGVRKTGQIWPNDGEG 420

Query: 421  AFHGDADGSFGTPPGYGCAADRAEEQRRHQDGLPYIDDSPSSSPHLSSKGRGSRDALVSG 480
            AFHGDADGSFGTPPGYGCAADRAEEQRRHQDGLPYIDDSPSSSPHLSSKGRGSRDALVSG
Sbjct: 421  AFHGDADGSFGTPPGYGCAADRAEEQRRHQDGLPYIDDSPSSSPHLSSKGRGSRDALVSG 480

Query: 481  ALESTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTS 540
            ALESTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTS
Sbjct: 481  ALESTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTS 540

Query: 541  QQIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGV 600
            QQIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGV
Sbjct: 541  QQIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGV 600

Query: 601  AMEMAEKCCQANAQFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLHDL 660
            AMEMAEKCCQANAQFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLHDL
Sbjct: 601  AMEMAEKCCQANAQFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLHDL 660

Query: 661  LKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGEHRQLLKDSFMVELVE 720
            LKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGEHRQLLKDSFMVELVE
Sbjct: 661  LKHTPASHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGEHRQLLKDSFMVELVE 720

Query: 721  GARKLRHVFLFTDLLLCTKLKKQSGGKTQQYDCKWYIPLTDLSFQMVDELEAVPNIPLVP 780
            GARKLRHVFLFTDLLLCTKLKKQSGGKTQQYDCKWYIPLTDLSFQMVDELEAVPNIPLVP
Sbjct: 721  GARKLRHVFLFTDLLLCTKLKKQSGGKTQQYDCKWYIPLTDLSFQMVDELEAVPNIPLVP 780

Query: 781  DEELDALKIKISQIKNDIQREKRANKGSKATERLKKKLSEQESLLLLMSPSMAFRVHSRN 840
            DEELDALKIKISQIKNDIQREKRANKGSKATERLKKKLSEQESLLLLMSPSMAFRVHSRN
Sbjct: 781  DEELDALKIKISQIKNDIQREKRANKGSKATERLKKKLSEQESLLLLMSPSMAFRVHSRN 840

Query: 841  GKSYTFLISSDYERAEWRENIREQQKKCFRSFSLTSVELQMLTNSCVKLQTVHSIPLTIN 900
            GKSYTFLISSDYERAEWRENIREQQKKCFRSFSLTSVELQMLTNSCVKLQTVHSIPLTIN
Sbjct: 841  GKSYTFLISSDYERAEWRENIREQQKKCFRSFSLTSVELQMLTNSCVKLQTVHSIPLTIN 900

Query: 901  KEDDESPGLYGFLNVIVHSATGFKQSSNLYCTLEVDSFGYFVNKAKTRVYRDTAEPNWNE 960
            KEDDESPGLYGFLNVIVHSATGFKQSSNLYCTLEVDSFGYFVNKAKTRVYRDTAEPNWNE
Sbjct: 901  KEDDESPGLYGFLNVIVHSATGFKQSSNLYCTLEVDSFGYFVNKAKTRVYRDTAEPNWNE 960

Query: 961  EFEIELEGSQTLRILCYEKCYNKTKIPKEDGESTDRLMGKGQVQLDPQALQDRDWQRTVI 1020
                                                        LDPQALQDRDWQRTVI
Sbjct: 961  --------------------------------------------LDPQALQDRDWQRTVI 976

Query: 1021 AMNGIEVKLSVKFNSREFSLKRMPSRKQTGVFGVKIAVVTKRERSKVPYIVRQCVEEIER 1080
            AMNGIEVKLSVKFNSREFSLKRMPSRKQTGVFGVKIAVVTKRERSKVPYIVRQCVEEIER
Sbjct: 977  AMNGIEVKLSVKFNSREFSLKRMPSRKQTGVFGVKIAVVTKRERSKVPYIVRQCVEEIER 1036

Query: 1081 RGMEEVGIYRVSGVATDIQALKAAFDVNNKDVSVMMSEMDVNAIAGTLKLYFRELPEPLF 1140
            RGMEEVGIYRVSGVATDIQALKAAFDVNNKDVSVMMSEMDVNAIAGTLKLYFRELPEPLF
Sbjct: 1037 RGMEEVGIYRVSGVATDIQALKAAFDVNNKDVSVMMSEMDVNAIAGTLKLYFRELPEPLF 1096

Query: 1141 TDEFYPNFAEGIALSDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSL 1200
            TDEFYPNFAEGIALSDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSL
Sbjct: 1097 TDEFYPNFAEGIALSDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSL 1156

Query: 1201 HNLATVFGPTLLRPSEKESKLPANPSQPITMTDSWSLEVMSQVQVLLYFLQLEAIPAPDS 1260
            HNLATVFGPTLLRPSEKESKLPANPSQPITMTDSWSLEVMSQVQVLLYFLQLEAIPAPDS
Sbjct: 1157 HNLATVFGPTLLRPSEKESKLPANPSQPITMTDSWSLEVMSQVQVLLYFLQLEAIPAPDS 1216

Query: 1261 KRQSILFSTEV 1271
            KRQSILFSTEV
Sbjct: 1217 KRQSILFSTEV 1227


>gi|38679957 active breakpoint cluster region-related  protein isoform
            a [Homo sapiens]
          Length = 859

 Score = 1136 bits (2939), Expect = 0.0
 Identities = 573/832 (68%), Positives = 685/832 (82%), Gaps = 11/832 (1%)

Query: 444  EEQRRHQDG---LPYIDDSPSSSPHLSSKGRGSRDALVSGALESTKASELDLEKGLEMRK 500
            EEQ+   +G   +PYID+SP+ SP LS++ +G  D  VS       A  ++  KGLEMRK
Sbjct: 35   EEQKGPPEGSETMPYIDESPTMSPQLSARSQGGGDG-VSPTPPEGLAPGVEAGKGLEMRK 93

Query: 501  WVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTSQQIETIFFKVPELYEIHKEF 560
             VLSG LASEE Y++ LEALLLPMKPLKA ATTSQPVLT QQIETIF+K+ ++YEIHKEF
Sbjct: 94   LVLSGFLASEEIYINQLEALLLPMKPLKATATTSQPVLTIQQIETIFYKIQDIYEIHKEF 153

Query: 561  YDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGVAMEMAEKCCQANAQFAEISE 620
            YD L P+VQQW  Q  +G LFQKLASQLGVY+AFVDNY VA+E AEKC Q+N QF +ISE
Sbjct: 154  YDNLCPKVQQWDSQVTMGHLFQKLASQLGVYKAFVDNYKVALETAEKCSQSNNQFQKISE 213

Query: 621  NLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPLLQDALRI 680
             L+ +  KD+KD  T  ++E LLYKP+DRVTRSTLVLHDLLKHTP  HPD+PLLQDALRI
Sbjct: 214  ELKVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPDYPLLQDALRI 273

Query: 681  SQNFLSSINEEITPRRQSMTVKKGEHRQLLKDSFMVELVEGARKLRHVFLFTDLLLCTKL 740
            SQNFLSSINE+I PRR ++T  KGE RQL+KD F+VE+ E +RKLRHVFLFTD+LLC KL
Sbjct: 274  SQNFLSSINEDIDPRRTAVTTPKGETRQLVKDGFLVEVSESSRKLRHVFLFTDVLLCAKL 333

Query: 741  KKQSGGKTQQYDCKWYIPLTDLSFQMVDELEAVPNIPLVPDEELDALKIKISQIKNDIQR 800
            KK S GK QQYDCKWYIPL DL F   +E EA P +   PD EL+ +K+KIS +K++IQ+
Sbjct: 334  KKTSAGKHQQYDCKWYIPLADLVFPSPEESEASPQVHPFPDHELEDMKMKISALKSEIQK 393

Query: 801  EKRANKG-SKATERLKKKLSEQESLLLLMSPSMAFRVHSRNGKSYTFLISSDYERAEWRE 859
            EK ANKG S+A ERLKKK+ E E LLLL SP++ FR+H+RNGKSY FL+SSDYER+EWRE
Sbjct: 394  EK-ANKGQSRAIERLKKKMFENEFLLLLNSPTIPFRIHNRNGKSYLFLLSSDYERSEWRE 452

Query: 860  NIREQQKKCFRSFSLTSVELQMLTNSCVKLQTVHSIPLTINKEDDESPGLYGFLNVIVHS 919
             I++ QKK  ++F L+SVELQ+LT SC KL+TVH+IP+T NK+DDESPGLYGFL+VIVHS
Sbjct: 453  AIQKLQKKDLQAFVLSSVELQVLTGSCFKLRTVHNIPVTSNKDDDESPGLYGFLHVIVHS 512

Query: 920  ATGFKQSSNLYCTLEVDSFGYFVNKAKTRVYRDTAEPNWNEEFEIELEGSQTLRILCYEK 979
            A GFKQS+NLYCTLEVDSFGYFV+KAKTRV+RDTAEP W+EEFEIELEGSQ+LRILCYEK
Sbjct: 513  AKGFKQSANLYCTLEVDSFGYFVSKAKTRVFRDTAEPKWDEEFEIELEGSQSLRILCYEK 572

Query: 980  CYNKTKIPKEDGESTDRLMGKGQVQLDPQALQDRDWQRTVIAMNGIEVKLSVKFNSREFS 1039
            CY+KTK+ K++ E  D++MGKGQ+QLDPQ ++ ++W   VI MNGI+V+ S+KF SR+ S
Sbjct: 573  CYDKTKVNKDNNEIVDKIMGKGQIQLDPQTVETKNWHTDVIEMNGIKVEFSMKFTSRDMS 632

Query: 1040 LKRMPSRKQTGVFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQ 1099
            LKR PS+KQTGVFGVKI+VVTKRERSKVPYIVRQCVEE+E+RG+EEVGIYR+SGVATDIQ
Sbjct: 633  LKRTPSKKQTGVFGVKISVVTKRERSKVPYIVRQCVEEVEKRGIEEVGIYRISGVATDIQ 692

Query: 1100 ALKAAFDVNNKDVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVA 1159
            ALKA FD NNKD+ +M+S+MD+NAIAGTLKLYFRELPEPL TD  YP F EGIALSDP A
Sbjct: 693  ALKAVFDANNKDILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAA 752

Query: 1160 KESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPSEKES 1219
            KE+CM++LL SLP+ NL+TFLFLL+HLKRVAEKE +NKMSLHNLATVFGPTLLRPSE ES
Sbjct: 753  KENCMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPSEVES 812

Query: 1220 KLPANPSQPITMTDSWSLEVMSQVQVLLYFLQLEAIPAPDSKRQSILFSTEV 1271
            K     +   +  D WS +VM+QVQVLLY+LQ   I   + KR ++ FST+V
Sbjct: 813  K-----AHLTSAADIWSHDVMAQVQVLLYYLQHPPISFAELKRNTLYFSTDV 859


>gi|229094128 active breakpoint cluster region-related  protein
            isoform c [Homo sapiens]
          Length = 813

 Score = 1134 bits (2933), Expect = 0.0
 Identities = 569/820 (69%), Positives = 679/820 (82%), Gaps = 8/820 (0%)

Query: 453  LPYIDDSPSSSPHLSSKGRGSRDALVSGALESTKASELDLEKGLEMRKWVLSGILASEET 512
            +PYID+SP+ SP LS++ +G  D  VS       A  ++  KGLEMRK VLSG LASEE 
Sbjct: 1    MPYIDESPTMSPQLSARSQGGGDG-VSPTPPEGLAPGVEAGKGLEMRKLVLSGFLASEEI 59

Query: 513  YLSHLEALLLPMKPLKAAATTSQPVLTSQQIETIFFKVPELYEIHKEFYDGLFPRVQQWS 572
            Y++ LEALLLPMKPLKA ATTSQPVLT QQIETIF+K+ ++YEIHKEFYD L P+VQQW 
Sbjct: 60   YINQLEALLLPMKPLKATATTSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWD 119

Query: 573  HQQRVGDLFQKLASQLGVYRAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNKDAKD 632
             Q  +G LFQKLASQLGVY+AFVDNY VA+E AEKC Q+N QF +ISE L+ +  KD+KD
Sbjct: 120  SQVTMGHLFQKLASQLGVYKAFVDNYKVALETAEKCSQSNNQFQKISEELKVKGPKDSKD 179

Query: 633  PTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPLLQDALRISQNFLSSINEEI 692
              T  ++E LLYKP+DRVTRSTLVLHDLLKHTP  HPD+PLLQDALRISQNFLSSINE+I
Sbjct: 180  SHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPDYPLLQDALRISQNFLSSINEDI 239

Query: 693  TPRRQSMTVKKGEHRQLLKDSFMVELVEGARKLRHVFLFTDLLLCTKLKKQSGGKTQQYD 752
             PRR ++T  KGE RQL+KD F+VE+ E +RKLRHVFLFTD+LLC KLKK S GK QQYD
Sbjct: 240  DPRRTAVTTPKGETRQLVKDGFLVEVSESSRKLRHVFLFTDVLLCAKLKKTSAGKHQQYD 299

Query: 753  CKWYIPLTDLSFQMVDELEAVPNIPLVPDEELDALKIKISQIKNDIQREKRANKG-SKAT 811
            CKWYIPL DL F   +E EA P +   PD EL+ +K+KIS +K++IQ+EK ANKG S+A 
Sbjct: 300  CKWYIPLADLVFPSPEESEASPQVHPFPDHELEDMKMKISALKSEIQKEK-ANKGQSRAI 358

Query: 812  ERLKKKLSEQESLLLLMSPSMAFRVHSRNGKSYTFLISSDYERAEWRENIREQQKKCFRS 871
            ERLKKK+ E E LLLL SP++ FR+H+RNGKSY FL+SSDYER+EWRE I++ QKK  ++
Sbjct: 359  ERLKKKMFENEFLLLLNSPTIPFRIHNRNGKSYLFLLSSDYERSEWREAIQKLQKKDLQA 418

Query: 872  FSLTSVELQMLTNSCVKLQTVHSIPLTINKEDDESPGLYGFLNVIVHSATGFKQSSNLYC 931
            F L+SVELQ+LT SC KL+TVH+IP+T NK+DDESPGLYGFL+VIVHSA GFKQS+NLYC
Sbjct: 419  FVLSSVELQVLTGSCFKLRTVHNIPVTSNKDDDESPGLYGFLHVIVHSAKGFKQSANLYC 478

Query: 932  TLEVDSFGYFVNKAKTRVYRDTAEPNWNEEFEIELEGSQTLRILCYEKCYNKTKIPKEDG 991
            TLEVDSFGYFV+KAKTRV+RDTAEP W+EEFEIELEGSQ+LRILCYEKCY+KTK+ K++ 
Sbjct: 479  TLEVDSFGYFVSKAKTRVFRDTAEPKWDEEFEIELEGSQSLRILCYEKCYDKTKVNKDNN 538

Query: 992  ESTDRLMGKGQVQLDPQALQDRDWQRTVIAMNGIEVKLSVKFNSREFSLKRMPSRKQTGV 1051
            E  D++MGKGQ+QLDPQ ++ ++W   VI MNGI+V+ S+KF SR+ SLKR PS+KQTGV
Sbjct: 539  EIVDKIMGKGQIQLDPQTVETKNWHTDVIEMNGIKVEFSMKFTSRDMSLKRTPSKKQTGV 598

Query: 1052 FGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNKD 1111
            FGVKI+VVTKRERSKVPYIVRQCVEE+E+RG+EEVGIYR+SGVATDIQALKA FD NNKD
Sbjct: 599  FGVKISVVTKRERSKVPYIVRQCVEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNKD 658

Query: 1112 VSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLLLSL 1171
            + +M+S+MD+NAIAGTLKLYFRELPEPL TD  YP F EGIALSDP AKE+CM++LL SL
Sbjct: 659  ILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKENCMMHLLRSL 718

Query: 1172 PEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPSEKESKLPANPSQPITM 1231
            P+ NL+TFLFLL+HLKRVAEKE +NKMSLHNLATVFGPTLLRPSE ESK     +   + 
Sbjct: 719  PDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPSEVESK-----AHLTSA 773

Query: 1232 TDSWSLEVMSQVQVLLYFLQLEAIPAPDSKRQSILFSTEV 1271
             D WS +VM+QVQVLLY+LQ   I   + KR ++ FST+V
Sbjct: 774  ADIWSHDVMAQVQVLLYYLQHPPISFAELKRNTLYFSTDV 813


>gi|38679954 active breakpoint cluster region-related  protein isoform
            b [Homo sapiens]
          Length = 822

 Score = 1112 bits (2877), Expect = 0.0
 Identities = 555/786 (70%), Positives = 660/786 (83%), Gaps = 7/786 (0%)

Query: 487  ASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTSQQIETI 546
            A +++  KGLEMRK VLSG LASEE Y++ LEALLLPMKPLKA ATTSQPVLT QQIETI
Sbjct: 43   AVKVEAGKGLEMRKLVLSGFLASEEIYINQLEALLLPMKPLKATATTSQPVLTIQQIETI 102

Query: 547  FFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDNYGVAMEMAE 606
            F+K+ ++YEIHKEFYD L P+VQQW  Q  +G LFQKLASQLGVY+AFVDNY VA+E AE
Sbjct: 103  FYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQLGVYKAFVDNYKVALETAE 162

Query: 607  KCCQANAQFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPA 666
            KC Q+N QF +ISE L+ +  KD+KD  T  ++E LLYKP+DRVTRSTLVLHDLLKHTP 
Sbjct: 163  KCSQSNNQFQKISEELKVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPV 222

Query: 667  SHPDHPLLQDALRISQNFLSSINEEITPRRQSMTVKKGEHRQLLKDSFMVELVEGARKLR 726
             HPD+PLLQDALRISQNFLSSINE+I PRR ++T  KGE RQL+KD F+VE+ E +RKLR
Sbjct: 223  DHPDYPLLQDALRISQNFLSSINEDIDPRRTAVTTPKGETRQLVKDGFLVEVSESSRKLR 282

Query: 727  HVFLFTDLLLCTKLKKQSGGKTQQYDCKWYIPLTDLSFQMVDELEAVPNIPLVPDEELDA 786
            HVFLFTD+LLC KLKK S GK QQYDCKWYIPL DL F   +E EA P +   PD EL+ 
Sbjct: 283  HVFLFTDVLLCAKLKKTSAGKHQQYDCKWYIPLADLVFPSPEESEASPQVHPFPDHELED 342

Query: 787  LKIKISQIKNDIQREKRANKG-SKATERLKKKLSEQESLLLLMSPSMAFRVHSRNGKSYT 845
            +K+KIS +K++IQ+EK ANKG S+A ERLKKK+ E E LLLL SP++ FR+H+RNGKSY 
Sbjct: 343  MKMKISALKSEIQKEK-ANKGQSRAIERLKKKMFENEFLLLLNSPTIPFRIHNRNGKSYL 401

Query: 846  FLISSDYERAEWRENIREQQKKCFRSFSLTSVELQMLTNSCVKLQTVHSIPLTINKEDDE 905
            FL+SSDYER+EWRE I++ QKK  ++F L+SVELQ+LT SC KL+TVH+IP+T NK+DDE
Sbjct: 402  FLLSSDYERSEWREAIQKLQKKDLQAFVLSSVELQVLTGSCFKLRTVHNIPVTSNKDDDE 461

Query: 906  SPGLYGFLNVIVHSATGFKQSSNLYCTLEVDSFGYFVNKAKTRVYRDTAEPNWNEEFEIE 965
            SPGLYGFL+VIVHSA GFKQS+NLYCTLEVDSFGYFV+KAKTRV+RDTAEP W+EEFEIE
Sbjct: 462  SPGLYGFLHVIVHSAKGFKQSANLYCTLEVDSFGYFVSKAKTRVFRDTAEPKWDEEFEIE 521

Query: 966  LEGSQTLRILCYEKCYNKTKIPKEDGESTDRLMGKGQVQLDPQALQDRDWQRTVIAMNGI 1025
            LEGSQ+LRILCYEKCY+KTK+ K++ E  D++MGKGQ+QLDPQ ++ ++W   VI MNGI
Sbjct: 522  LEGSQSLRILCYEKCYDKTKVNKDNNEIVDKIMGKGQIQLDPQTVETKNWHTDVIEMNGI 581

Query: 1026 EVKLSVKFNSREFSLKRMPSRKQTGVFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEE 1085
            +V+ S+KF SR+ SLKR PS+KQTGVFGVKI+VVTKRERSKVPYIVRQCVEE+E+RG+EE
Sbjct: 582  KVEFSMKFTSRDMSLKRTPSKKQTGVFGVKISVVTKRERSKVPYIVRQCVEEVEKRGIEE 641

Query: 1086 VGIYRVSGVATDIQALKAAFDVNNKDVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFY 1145
            VGIYR+SGVATDIQALKA FD NNKD+ +M+S+MD+NAIAGTLKLYFRELPEPL TD  Y
Sbjct: 642  VGIYRISGVATDIQALKAVFDANNKDILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLY 701

Query: 1146 PNFAEGIALSDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLAT 1205
            P F EGIALSDP AKE+CM++LL SLP+ NL+TFLFLL+HLKRVAEKE +NKMSLHNLAT
Sbjct: 702  PAFMEGIALSDPAAKENCMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLAT 761

Query: 1206 VFGPTLLRPSEKESKLPANPSQPITMTDSWSLEVMSQVQVLLYFLQLEAIPAPDSKRQSI 1265
            VFGPTLLRPSE ESK     +   +  D WS +VM+QVQVLLY+LQ   I   + KR ++
Sbjct: 762  VFGPTLLRPSEVESK-----AHLTSAADIWSHDVMAQVQVLLYYLQHPPISFAELKRNTL 816

Query: 1266 LFSTEV 1271
             FST+V
Sbjct: 817  YFSTDV 822


>gi|239746665 PREDICTED: hypothetical protein XP_002343826 [Homo
            sapiens]
          Length = 181

 Score =  174 bits (441), Expect = 5e-43
 Identities = 86/93 (92%), Positives = 91/93 (97%)

Query: 1153 ALSDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLL 1212
            ALSDPVAK+SCMLNLL SLPEANLLTFLFLLDHL+R+AEKEAVNKMSLHNL TVFGPTLL
Sbjct: 39   ALSDPVAKKSCMLNLLSSLPEANLLTFLFLLDHLERMAEKEAVNKMSLHNLGTVFGPTLL 98

Query: 1213 RPSEKESKLPANPSQPITMTDSWSLEVMSQVQV 1245
            RPSEKESKLPANPSQPITMTDSWSLEVMSQ+Q+
Sbjct: 99   RPSEKESKLPANPSQPITMTDSWSLEVMSQIQI 131


>gi|239757684 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 181

 Score =  169 bits (429), Expect = 1e-41
 Identities = 86/93 (92%), Positives = 91/93 (97%)

Query: 1153 ALSDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLL 1212
            ALSDPVA++SCMLNLLLSLPEANLLTFLFLLD L+RVAEKEAVNKMSLHNLATVFGPTLL
Sbjct: 39   ALSDPVARKSCMLNLLLSLPEANLLTFLFLLDRLERVAEKEAVNKMSLHNLATVFGPTLL 98

Query: 1213 RPSEKESKLPANPSQPITMTDSWSLEVMSQVQV 1245
            RPSEKESKLPANPSQPITMTDS SLEVMSQ+Q+
Sbjct: 99   RPSEKESKLPANPSQPITMTDSRSLEVMSQIQI 131


>gi|239752174 PREDICTED: hypothetical protein XP_002348160 [Homo
            sapiens]
          Length = 181

 Score =  169 bits (429), Expect = 1e-41
 Identities = 86/93 (92%), Positives = 91/93 (97%)

Query: 1153 ALSDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLL 1212
            ALSDPVA++SCMLNLLLSLPEANLLTFLFLLD L+RVAEKEAVNKMSLHNLATVFGPTLL
Sbjct: 39   ALSDPVARKSCMLNLLLSLPEANLLTFLFLLDRLERVAEKEAVNKMSLHNLATVFGPTLL 98

Query: 1213 RPSEKESKLPANPSQPITMTDSWSLEVMSQVQV 1245
            RPSEKESKLPANPSQPITMTDS SLEVMSQ+Q+
Sbjct: 99   RPSEKESKLPANPSQPITMTDSRSLEVMSQIQI 131


>gi|239746697 PREDICTED: hypothetical protein XP_002343833 [Homo
            sapiens]
          Length = 181

 Score =  169 bits (429), Expect = 1e-41
 Identities = 86/93 (92%), Positives = 91/93 (97%)

Query: 1153 ALSDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLL 1212
            ALSDPVA++SCMLNLLLSLPEANLLTFLFLLD L+RVAEKEAVNKMSLHNLATVFGPTLL
Sbjct: 39   ALSDPVARKSCMLNLLLSLPEANLLTFLFLLDRLERVAEKEAVNKMSLHNLATVFGPTLL 98

Query: 1213 RPSEKESKLPANPSQPITMTDSWSLEVMSQVQV 1245
            RPSEKESKLPANPSQPITMTDS SLEVMSQ+Q+
Sbjct: 99   RPSEKESKLPANPSQPITMTDSRSLEVMSQIQI 131


>gi|226693398 Rho GTPase activating protein 27 isoform b [Homo
            sapiens]
          Length = 521

 Score =  138 bits (347), Expect = 4e-32
 Identities = 85/208 (40%), Positives = 121/208 (58%), Gaps = 10/208 (4%)

Query: 1024 GIEVKLS-VKFNSREFSLKR--MPSRKQTG-----VFGVKIAVVTKRERSKVPYIVRQCV 1075
            G+E  LS V+   R+F  +R  + S ++ G     VFG  +A + +RERS+VP  V+QC+
Sbjct: 291  GLESDLSKVRHKLRKFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCI 350

Query: 1076 EEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNK-DVSVMMSEMDVNAIAGTLKLYFRE 1134
              +E RG++  G+YR+SG    IQ L+   D + + D+     E DV+ I G LKL+FRE
Sbjct: 351  RAVEARGLDIDGLYRISGNLATIQKLRYKVDHDERLDLDDGRWE-DVHVITGALKLFFRE 409

Query: 1135 LPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEA 1194
            LPEPLF    +  F   I L D   +  C+ +L+ SLP  N  T   L  HL RV E   
Sbjct: 410  LPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGE 469

Query: 1195 VNKMSLHNLATVFGPTLLRPSEKESKLP 1222
             N+MS+ ++A VFGPTLLRP  +E+ +P
Sbjct: 470  QNRMSVQSVAIVFGPTLLRPEVEETSMP 497


>gi|40548322 Rho GTPase activating protein 27 isoform a [Homo sapiens]
          Length = 548

 Score =  138 bits (347), Expect = 4e-32
 Identities = 85/208 (40%), Positives = 121/208 (58%), Gaps = 10/208 (4%)

Query: 1024 GIEVKLS-VKFNSREFSLKR--MPSRKQTG-----VFGVKIAVVTKRERSKVPYIVRQCV 1075
            G+E  LS V+   R+F  +R  + S ++ G     VFG  +A + +RERS+VP  V+QC+
Sbjct: 318  GLESDLSKVRHKLRKFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCI 377

Query: 1076 EEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNK-DVSVMMSEMDVNAIAGTLKLYFRE 1134
              +E RG++  G+YR+SG    IQ L+   D + + D+     E DV+ I G LKL+FRE
Sbjct: 378  RAVEARGLDIDGLYRISGNLATIQKLRYKVDHDERLDLDDGRWE-DVHVITGALKLFFRE 436

Query: 1135 LPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEA 1194
            LPEPLF    +  F   I L D   +  C+ +L+ SLP  N  T   L  HL RV E   
Sbjct: 437  LPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGE 496

Query: 1195 VNKMSLHNLATVFGPTLLRPSEKESKLP 1222
             N+MS+ ++A VFGPTLLRP  +E+ +P
Sbjct: 497  QNRMSVQSVAIVFGPTLLRPEVEETSMP 524


>gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17 [Homo
            sapiens]
          Length = 2063

 Score =  134 bits (337), Expect = 6e-31
 Identities = 97/316 (30%), Positives = 154/316 (48%), Gaps = 46/316 (14%)

Query: 483  ESTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLP-MKPLKAAATTSQPVLTSQ 541
            E T AS+   +  ++MRK V   +L +E++Y+  L  L+   M+PLK    +   +    
Sbjct: 1051 EPTPASKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSV--LCDPS 1108

Query: 542  QIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQ---LGVYRAFVDNY 598
             ++ IF ++PEL E H++F + +   +Q W  QQ+VG L  +  S+   + +Y A++DN+
Sbjct: 1109 LVDEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNF 1168

Query: 599  GVAMEMAEKCCQANAQFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLH 658
              A +      +A   F +  E    R NK+      K +L  L+ KPV R+ R  L++ 
Sbjct: 1169 LNAKDAVRVAKEARPAFLKFLEQ-SMRENKE------KQALSDLMIKPVQRIPRYELLVK 1221

Query: 659  DLLKHTPASHPDHPLLQDALRISQNFLSSIN----------------EEITPRRQSMTVK 702
            DLLKHTP  HPDHPLL +A R  +     IN                +EI    + M   
Sbjct: 1222 DLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDL 1281

Query: 703  KGEHRQLLKDSFMVEL-VEGARKLRHVFLFTDLLLCTKLKKQSGG--------------- 746
            +   R+ L+   ++E+   G +K R +FLFTDL++CT LK++SG                
Sbjct: 1282 QAPLRRFLRQEMVIEVKAIGGKKDRSLFLFTDLIVCTTLKRKSGSLRRSSMSLYTAASVI 1341

Query: 747  -KTQQYDCKWYIPLTD 761
                +Y   W +PL D
Sbjct: 1342 DTASKYKMLWKLPLED 1357



 Score = 34.7 bits (78), Expect = 0.60
 Identities = 69/289 (23%), Positives = 101/289 (34%), Gaps = 37/289 (12%)

Query: 84  PDGASEPRASASRPQPAPADGADPPPAEEPEARPDGEGSPGKARPG----------TARR 133
           P G+S  R S       P DG D P A  P  + +    P  A PG          T RR
Sbjct: 490 PGGSSGDRGSN------PLDGRDSPSAGGPVGQLEPIPIPAPASPGTRPTLKDLTATLRR 543

Query: 134 PGAAASGERD-DRGPPASVAALRSNFERIRKGHGQPGADAEK-PFYVNVEFHHERGLVKV 191
             +    E+   R  P + A   S+ E +  G   PGA+ +  P  V  ++  E      
Sbjct: 544 AKSFTCSEKPMARRLPRTSALKSSSSELLLTG---PGAEEDPLPLIVQDQYVQEA----- 595

Query: 192 NDKEVSDRISSLGSQAMQMERKKSQHGAGSSVGDASRPPYRGRSSESSCGVDGDYEDAEL 251
             ++V ++I  +G+Q  Q +   +  G+    GD +R     RS E   G +    D  +
Sbjct: 596 --RQVFEKIQRMGAQ--QDDGSDAPPGSPDWAGDVTRGQ---RSQEELSGPESSLTDEGI 648

Query: 252 NPRFLKDNLIDANGGSRPPWPPLEYQPYQSIYVGGMMEGEGKGPLLRSQSTSEQEKRLTW 311
                         G+   W PL     Q+ + G   E    G  L S  T      L  
Sbjct: 649 GADPEPPVAAFCGLGTTGMWRPLSSSSAQTNHHGPGTEDSLGGWALVSPETPPTPGALR- 707

Query: 312 PRRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTY 360
            RR   P S    GG    +  + E   S  +       +  S  PT +
Sbjct: 708 -RRRKVPPS--GSGGSELSNGEAGEAYRSLSDPIPQRHRAATSEEPTGF 753


>gi|149274655 synapse defective 1, Rho GTPase, homolog 2 [Homo
            sapiens]
          Length = 1194

 Score =  133 bits (334), Expect = 1e-30
 Identities = 116/396 (29%), Positives = 189/396 (47%), Gaps = 39/396 (9%)

Query: 880  QMLTNSCVKLQTVHSIPLTINKEDDESPGLY--GFLNVIVHSATGFK----QSSNLYCTL 933
            ++++NSC K +         +  D      Y  G ++V  + A   K     S +++C +
Sbjct: 647  EIISNSCSKNEIDIDAFRHYSFSDQPKCSQYISGLMSVHFYGAEDLKPPRIDSKDVFCAI 706

Query: 934  EVDSFGYFVNKAKTRVYR-DTAEPNWNEEFEIELEGSQTLRILCYEKCYNKTKIPKEDGE 992
            +VDS    VNKA+T +    T   + +  F IE+E +Q L+++ +           E   
Sbjct: 707  QVDS----VNKARTALLTCRTTFLDMDHTFNIEIENAQHLKLVVFSW---------EPTP 753

Query: 993  STDRLMGKGQVQLDPQALQDRDWQRTV-IAMNGIEVKLSVKFNSREFSLKRMPSRKQTGV 1051
              +R+   G V L       +  Q  V +   G+           E SL  +   ++  +
Sbjct: 754  RKNRVCCHGTVVLPTLFRVTKTHQLAVKLEPRGLIYVKVTLMEQWENSLHGLDINQEPII 813

Query: 1052 FGVKIAVVTKRERS--KVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNN 1109
            FGV I  V ++E     VP ++++C+ EIE+RG + VG+YR+ G A   + L+ AF+ ++
Sbjct: 814  FGVDIQKVVEKENIGLMVPLLIQKCIMEIEKRGCQVVGLYRLCGSAAVKKELREAFERDS 873

Query: 1110 KDVSVMMSEM-DVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSD-PVAKESC---- 1163
            K V +  ++  D+N I G LK Y RELP PL T + Y    + +A S   ++   C    
Sbjct: 874  KAVGLCENQYPDINVITGVLKDYLRELPSPLITKQLYEAVLDAMAKSPLKMSSNGCENDP 933

Query: 1164 -----MLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPSEKE 1218
                  ++LL  LPE    T   LLDHLK VA    VNKM+  NLA  FGP LL   ++ 
Sbjct: 934  GDSKYTVDLLDCLPEIEKATLKMLLDHLKLVASYHEVNKMTCQNLAVCFGPVLLSQRQEP 993

Query: 1219 SKLPANPSQPITMTD--SWSLEVMSQVQVLLYFLQL 1252
            S    + ++  T ++  + +L+    ++VL Y LQL
Sbjct: 994  S---THNNRVFTDSEELASALDFKKHIEVLHYLLQL 1026


>gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens]
          Length = 459

 Score =  129 bits (325), Expect = 1e-29
 Identities = 73/176 (41%), Positives = 100/176 (56%), Gaps = 3/176 (1%)

Query: 1051 VFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNK 1110
            V+   +  + K   +K P +V  C+ EIE RG+   G+YRVSG +  I+ +K AFD + +
Sbjct: 265  VYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGE 324

Query: 1111 --DVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLL 1168
              D+SV M E D+N I G LKLYFR+LP PL T + YP F E   + DP  +   +   L
Sbjct: 325  KADISVNMYE-DINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEAL 383

Query: 1169 LSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPSEKESKLPAN 1224
              LP A+  T  +L+ HLKRV   E  N M+  NL  VFGPTL+R  E ++    N
Sbjct: 384  KLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALN 439


>gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens]
          Length = 433

 Score =  129 bits (325), Expect = 1e-29
 Identities = 73/176 (41%), Positives = 100/176 (56%), Gaps = 3/176 (1%)

Query: 1051 VFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNK 1110
            V+   +  + K   +K P +V  C+ EIE RG+   G+YRVSG +  I+ +K AFD + +
Sbjct: 239  VYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGE 298

Query: 1111 --DVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLL 1168
              D+SV M E D+N I G LKLYFR+LP PL T + YP F E   + DP  +   +   L
Sbjct: 299  KADISVNMYE-DINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEAL 357

Query: 1169 LSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPSEKESKLPAN 1224
              LP A+  T  +L+ HLKRV   E  N M+  NL  VFGPTL+R  E ++    N
Sbjct: 358  KLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALN 413


>gi|188497642 ARHGAP15 [Homo sapiens]
          Length = 475

 Score =  125 bits (313), Expect = 3e-28
 Identities = 73/194 (37%), Positives = 107/194 (55%), Gaps = 6/194 (3%)

Query: 1032 KFNSREFSLKRMPSRK--QTGVFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIY 1089
            KF +R  SLK +  +   +  +FG  +  V +RE S VP+ V+QC+E +E+RG++  GIY
Sbjct: 257  KFITRRPSLKTLQEKGLIKDQIFGSHLHKVCERENSTVPWFVKQCIEAVEKRGLDVDGIY 316

Query: 1090 RVSGVATDIQALKAAFDVNNKDVSVMMSEM--DVNAIAGTLKLYFRELPEPLFTDEFYPN 1147
            RVSG    IQ L+  F VN ++   +      D++ + G LK++FRELPEPLF   F+  
Sbjct: 317  RVSGNLATIQKLR--FIVNQEEKLNLDDSQWEDIHVVTGALKMFFRELPEPLFPYSFFEQ 374

Query: 1148 FAEGIALSDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVF 1207
            F E I   D   +   + +L+  LP  N  T   L  HL ++  K + N MS  +L  VF
Sbjct: 375  FVEAIKKQDNNTRIEAVKSLVQKLPPPNRDTMKVLFGHLTKIVAKASKNLMSTQSLGIVF 434

Query: 1208 GPTLLRPSEKESKL 1221
            GPTLLR   +   +
Sbjct: 435  GPTLLRAENETGNM 448


>gi|42475970 synapse defective 1, Rho GTPase, homolog 1 [Homo sapiens]
          Length = 735

 Score =  121 bits (303), Expect = 5e-27
 Identities = 111/372 (29%), Positives = 176/372 (47%), Gaps = 42/372 (11%)

Query: 909  LYGFLNVIVHSATGFKQSS-----NLYCTLEVDSFGYFVNKAKTRVYRDTAEPNW---NE 960
            L+G L++ ++   G + +      +L C L+VD       +A+ R       P++   + 
Sbjct: 264  LWGRLSLHLYGLGGLRPAPGATPRDLCCLLQVDG------EARARTGPLRGGPDFLRLDH 317

Query: 961  EFEIELEGSQTLRILCYEKCYNKTKIPKEDGESTDRLMGKGQVQLDPQALQDRDWQRTVI 1020
             F +ELE ++ LR L          +  + G    R   +G V L P   +    Q+  +
Sbjct: 318  TFHLELEAARLLRALV---------LAWDPGVRRHRPCAQGTVLL-PTVFRGCQAQQLAV 367

Query: 1021 AMNGIEVKLSVKFNSREFSLKRMPSRKQTGVFGVKIAVVTKRER--SKVPYIVRQCVEEI 1078
             +   +  L  K    E   +  P+  +  VFG+ + ++ +RER   +VP I+++CV +I
Sbjct: 368  RLEP-QGLLYAKLTLSE--QQEAPATAEPRVFGLPLPLLVERERPPGQVPLIIQKCVGQI 424

Query: 1079 ERRGMEEVGIYRVSGVATDIQALKAAFDVNNKDVSVMMSE---MDVNAIAGTLKLYFREL 1135
            ERRG+  VG+YR+ G A   + L+ AF+ ++   +V +SE    D+N I G LK Y REL
Sbjct: 425  ERRGLRVVGLYRLCGSAAVKKELRDAFERDS--AAVCLSEDLYPDINVITGILKDYLREL 482

Query: 1136 PEPLFTDEFYPNFAEGIALSDP---VAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEK 1192
            P PL T   Y    E +A   P            LL  LP+    T   LLDHL+ V+  
Sbjct: 483  PTPLITQPLYKVVLEAMARDPPNRVPPTTEGTRGLLSCLPDVERATLTLLLDHLRLVSSF 542

Query: 1193 EAVNKMSLHNLATVFGPTLLRPSEKESKLPANPSQPITMTDSWSLEVMSQVQVLLYFLQL 1252
             A N+M+  NLA  FGP LL   +  ++  A  S P   +   +++    ++VL Y LQ 
Sbjct: 543  HAYNRMTPQNLAVCFGPVLLPARQAPTRPRARSSGPGLAS---AVDFKHHIEVLHYLLQ- 598

Query: 1253 EAIPAPDSKRQS 1264
             + P P   RQS
Sbjct: 599  -SWPDPRLPRQS 609



 Score = 31.2 bits (69), Expect = 6.6
 Identities = 23/74 (31%), Positives = 35/74 (47%), Gaps = 11/74 (14%)

Query: 67  KKSYDRQRWGFRRAAQAPDGASEPRASASRPQPAPADGADPPPAEEPEARPDGE--GSPG 124
           +K++ R R G  +  +    A E    A RP+P+P       P  EP+A P+G   G+ G
Sbjct: 7   RKTFSRLR-GREKLPRKKSDAKERGHPAQRPEPSP-------PEPEPQA-PEGSQAGAEG 57

Query: 125 KARPGTARRPGAAA 138
            + P  +R P   A
Sbjct: 58  PSSPEASRSPARGA 71



 Score = 31.2 bits (69), Expect = 6.6
 Identities = 37/159 (23%), Positives = 53/159 (33%), Gaps = 21/159 (13%)

Query: 13  AQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQTLLAKEKKSYDR 72
           AQ P+  PP  E ++    +   E   +       E ++   R  YLQ+L    +     
Sbjct: 33  AQRPEPSPPEPEPQAPEGSQAGAEGPSSP------EASRSPARGAYLQSLEPSSR----- 81

Query: 73  QRWGFRRAAQAPD--------GASEPRASASRPQPAPADGADPPPAEEPEARPDGEGSPG 124
            RW    A  A D        G  EP A      P P +   PP  E P  +P    S G
Sbjct: 82  -RWVLGGAKPAEDTSLGPGVPGTGEP-AGEIWYNPIPEEDPRPPAPEPPGPQPGSAESEG 139

Query: 125 KARPGTARRPGAAASGERDDRGPPASVAALRSNFERIRK 163
            A  G A       +      GP   ++        +R+
Sbjct: 140 LAPQGAAPASPPTKASRTKSPGPARRLSIKMKKLPELRR 178


>gi|26986534 Rho GTPase activating protein 12 [Homo sapiens]
          Length = 846

 Score =  119 bits (298), Expect = 2e-26
 Identities = 83/228 (36%), Positives = 130/228 (57%), Gaps = 16/228 (7%)

Query: 1000 KGQVQLDPQALQDRDWQRTVIAMNGIEVKLSVKFNSREFSLKR--MPSRKQTG-----VF 1052
            K + Q DP+ L+       V +++  E K + K N ++F  +R  + + ++ G     VF
Sbjct: 600  KEKEQKDPKKLRSFK----VSSIDSSEQKKTKK-NLKKFLTRRPTLQAVREKGYIKDQVF 654

Query: 1053 GVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNK-D 1111
            G  +A + +RE   VP  V+ C+E +E  G++  GIYRVSG    IQ L+ A + + K D
Sbjct: 655  GSNLANLCQRENGTVPKFVKLCIEHVEEHGLDIDGIYRVSGNLAVIQKLRFAVNHDEKLD 714

Query: 1112 VSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLLLSL 1171
            ++    E D++ I G LK++FRELPEPLFT   + +F   I   +P  + + + +L+  L
Sbjct: 715  LNDSKWE-DIHVITGALKMFFRELPEPLFTFNHFNDFVNAIK-QEPRQRVAAVKDLIRQL 772

Query: 1172 PEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPSEKES 1219
            P+ N  T   L  HL+RV E    N+M+  ++A VFGPTLL+P EKE+
Sbjct: 773  PKPNQDTMQILFRHLRRVIENGEKNRMTYQSIAIVFGPTLLKP-EKET 819


>gi|203097003 Rho GTPase activating protein 21 [Homo sapiens]
          Length = 1958

 Score =  118 bits (296), Expect = 3e-26
 Identities = 68/170 (40%), Positives = 96/170 (56%), Gaps = 2/170 (1%)

Query: 1049 TGVFGVKIAVVTKRERSK-VPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDV 1107
            TG FGV++        ++ +P IV  C + +E RG+E  GIYRV G    I +++   + 
Sbjct: 1142 TGTFGVRLDDCPPAHTNRYIPLIVDICCKLVEERGLEYTGIYRVPGNNAAISSMQEELNK 1201

Query: 1108 NNKDVSVMMSEM-DVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKESCMLN 1166
               D+ +   +  D+N I+  LK +FR+LPEPLFT++ Y +F E     DP+ +   +  
Sbjct: 1202 GMADIDIQDDKWRDLNVISSLLKSFFRKLPEPLFTNDKYADFIEANRKEDPLDRLKTLKR 1261

Query: 1167 LLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPSE 1216
            L+  LPE +  T  FL  HLK VAE    NKM   NLA VFGPTL+R SE
Sbjct: 1262 LIHDLPEHHYETLKFLSAHLKTVAENSEKNKMEPRNLAIVFGPTLVRTSE 1311


>gi|4757980 beta chimerin isoform 2 [Homo sapiens]
          Length = 468

 Score =  117 bits (293), Expect = 7e-26
 Identities = 62/167 (37%), Positives = 95/167 (56%), Gaps = 1/167 (0%)

Query: 1051 VFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNK 1110
            V+   +  + K   ++ P +V  C+ EIE RG++  G+YRVSG    I+ +K AFD + +
Sbjct: 274  VYCCDLTTLVKAHNTQRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGE 333

Query: 1111 DVSVMMSEM-DVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLLL 1169
               +  +   D+N I G LKLYFR+LP P+ T + Y  F +   +S+   +   +  +L+
Sbjct: 334  KADISANVYPDINIITGALKLYFRDLPIPVITYDTYSKFIDAAKISNADERLEAVHEVLM 393

Query: 1170 SLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPSE 1216
             LP A+  T  +L+ HLK+V   E  N M+  NL  VFGPTL+RP E
Sbjct: 394  LLPPAHYETLRYLMIHLKKVTMNEKDNFMNAENLGIVFGPTLMRPPE 440


>gi|91106928 beta chimerin isoform 1 [Homo sapiens]
          Length = 332

 Score =  117 bits (293), Expect = 7e-26
 Identities = 62/167 (37%), Positives = 95/167 (56%), Gaps = 1/167 (0%)

Query: 1051 VFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNK 1110
            V+   +  + K   ++ P +V  C+ EIE RG++  G+YRVSG    I+ +K AFD + +
Sbjct: 138  VYCCDLTTLVKAHNTQRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGE 197

Query: 1111 DVSVMMSEM-DVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLLL 1169
               +  +   D+N I G LKLYFR+LP P+ T + Y  F +   +S+   +   +  +L+
Sbjct: 198  KADISANVYPDINIITGALKLYFRDLPIPVITYDTYSKFIDAAKISNADERLEAVHEVLM 257

Query: 1170 SLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPSE 1216
             LP A+  T  +L+ HLK+V   E  N M+  NL  VFGPTL+RP E
Sbjct: 258  LLPPAHYETLRYLMIHLKKVTMNEKDNFMNAENLGIVFGPTLMRPPE 304


>gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]
          Length = 1397

 Score =  112 bits (280), Expect = 2e-24
 Identities = 65/167 (38%), Positives = 91/167 (54%), Gaps = 2/167 (1%)

Query: 1052 FGVKIAVVTKR-ERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNK 1110
            FGV++       E  +VP IV  C   +E RG+E  GIYRV G    + +L+   +    
Sbjct: 809  FGVRLEECQPATENQRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRGPG 868

Query: 1111 DVSVMMSE-MDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLLL 1169
            D+++      D+N I+  LK +FR+LPEPLFTD+ Y +F E   + D   +   +  L+ 
Sbjct: 869  DINLQDERWQDLNVISSLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARERMRTLRKLIR 928

Query: 1170 SLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPSE 1216
             LP     T  FL+ HLK +A+    NKM   NLA VFGPTL+R SE
Sbjct: 929  DLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLVRTSE 975



 Score = 36.6 bits (83), Expect = 0.16
 Identities = 28/84 (33%), Positives = 36/84 (42%), Gaps = 4/84 (4%)

Query: 80   AAQAPDGASEPRASASRPQPAPADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAAS 139
            A   P G    R S S     P D            RPDGEG+ G+  P     PG+A+S
Sbjct: 1199 AGAGPGGRLTRRPSFSSHHLMPCDTL--ARRRLARGRPDGEGA-GRGGPRAPEPPGSASS 1255

Query: 140  GERDDRGPPASVAALR-SNFERIR 162
              ++   PPA+  A R S  E +R
Sbjct: 1256 SSQESLRPPAAALASRPSRMEALR 1279


>gi|62548864 Rho guanine nucleotide exchange factor 10 [Homo
           sapiens]
          Length = 1344

 Score =  110 bits (274), Expect = 1e-23
 Identities = 78/291 (26%), Positives = 136/291 (46%), Gaps = 38/291 (13%)

Query: 498 MRKWVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTSQQIETIFFKVPELYEIH 557
           +R+++L  ++ SE+ Y+  L+ +L   +  K  +     VL+ ++++T+F++V E+ + H
Sbjct: 396 VRRYILGSVVDSEKNYVDALKRILEQYE--KPLSEMEPKVLSERKLKTVFYRVKEILQCH 453

Query: 558 KEFYDGLFPRVQQWSHQQRVGDLFQKLASQ---LGVYRAFVDNYGVAMEMAEKCCQANAQ 614
             F   L  RV +W   + +GD+F    S+   L  Y  +V+N+  A+ + +K C     
Sbjct: 454 SLFQIALASRVSEWDSVEMIGDVFVASFSKSMVLDAYSEYVNNFSTAVAVLKKTCATKPA 513

Query: 615 FAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPLL 674
           F E  +    +  + + D TT   L +L+ KP+ R  +  L+L D+LK+T   HPD   L
Sbjct: 514 FLEFLK----QEQEASPDRTT---LYSLMMKPIQRFPQFILLLQDMLKNTSKGHPDRLPL 566

Query: 675 QDALRISQNFLSSINEEITPRRQSMTVKK---------------GEHRQLLKDSFMVELV 719
           Q AL   +     +NE      Q   VK+                  R L++   M+E V
Sbjct: 567 QMALTELETLAEKLNERKRDADQRCEVKQIAKAINERYLNKLLSSGSRYLIRSDDMIETV 626

Query: 720 EGAR------KLRHVFLFTDLLLCTKLKKQSGG-----KTQQYDCKWYIPL 759
              R      K R VF+  D+L+C  +  +         +Q+Y  KW +PL
Sbjct: 627 YNDRGEIVKTKERRVFMLNDVLMCATVSSRPSHDSRVMSSQRYLLKWSVPL 677


>gi|122939147 Rho GTPase activating protein 9 isoform 1 [Homo sapiens]
          Length = 731

 Score =  109 bits (273), Expect = 1e-23
 Identities = 80/260 (30%), Positives = 125/260 (48%), Gaps = 23/260 (8%)

Query: 989  EDGESTDRLMGKGQVQLDPQALQDRDWQRTVIAMNGIEVKLSVKFNSREFSLKRMPSRK- 1047
            ED E    L+ K  ++L  +    R  + T    N +  KL  +  ++   L+ +  R  
Sbjct: 459  EDEEEESELVSKPLLRLSSRRSSIRGPEGT--EQNRVRNKLK-RLIAKRPPLQSLQERGL 515

Query: 1048 -QTGVFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFD 1106
             +  VFG ++  + +RE   VP  +R C+  +++RG++  GIYRVSG    +Q L+   D
Sbjct: 516  LRDQVFGCQLESLCQREGDTVPSFLRLCIAAVDKRGLDVDGIYRVSGNLAVVQKLRFLVD 575

Query: 1107 VNN---KDVSVMMSEM---------------DVNAIAGTLKLYFRELPEPLFTDEFYPNF 1148
                   D   +  E                D++ + G LKL+ RELP+PL      P+F
Sbjct: 576  RERAVTSDGRYVFPEQPGQEGRLDLDSTEWDDIHVVTGALKLFLRELPQPLVPPLLLPHF 635

Query: 1149 AEGIALSDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFG 1208
               +ALS+     S +  L+ S+P+ N  T  +LL+HL RV      N+M+ HNL  VFG
Sbjct: 636  RAALALSESEQCLSQIQELIGSMPKPNHDTLRYLLEHLCRVIAHSDKNRMTPHNLGIVFG 695

Query: 1209 PTLLRPSEKESKLPANPSQP 1228
            PTL RP ++ S   A+   P
Sbjct: 696  PTLFRPEQETSDPAAHALYP 715


>gi|122939149 Rho GTPase activating protein 9 isoform 3 [Homo sapiens]
          Length = 547

 Score =  109 bits (273), Expect = 1e-23
 Identities = 80/260 (30%), Positives = 125/260 (48%), Gaps = 23/260 (8%)

Query: 989  EDGESTDRLMGKGQVQLDPQALQDRDWQRTVIAMNGIEVKLSVKFNSREFSLKRMPSRK- 1047
            ED E    L+ K  ++L  +    R  + T    N +  KL  +  ++   L+ +  R  
Sbjct: 275  EDEEEESELVSKPLLRLSSRRSSIRGPEGT--EQNRVRNKLK-RLIAKRPPLQSLQERGL 331

Query: 1048 -QTGVFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFD 1106
             +  VFG ++  + +RE   VP  +R C+  +++RG++  GIYRVSG    +Q L+   D
Sbjct: 332  LRDQVFGCQLESLCQREGDTVPSFLRLCIAAVDKRGLDVDGIYRVSGNLAVVQKLRFLVD 391

Query: 1107 VNN---KDVSVMMSEM---------------DVNAIAGTLKLYFRELPEPLFTDEFYPNF 1148
                   D   +  E                D++ + G LKL+ RELP+PL      P+F
Sbjct: 392  RERAVTSDGRYVFPEQPGQEGRLDLDSTEWDDIHVVTGALKLFLRELPQPLVPPLLLPHF 451

Query: 1149 AEGIALSDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFG 1208
               +ALS+     S +  L+ S+P+ N  T  +LL+HL RV      N+M+ HNL  VFG
Sbjct: 452  RAALALSESEQCLSQIQELIGSMPKPNHDTLRYLLEHLCRVIAHSDKNRMTPHNLGIVFG 511

Query: 1209 PTLLRPSEKESKLPANPSQP 1228
            PTL RP ++ S   A+   P
Sbjct: 512  PTLFRPEQETSDPAAHALYP 531


>gi|47834348 minor histocompatibility antigen HA-1 [Homo sapiens]
          Length = 1136

 Score =  108 bits (269), Expect = 4e-23
 Identities = 76/201 (37%), Positives = 104/201 (51%), Gaps = 26/201 (12%)

Query: 1041 KRMPSRKQTGVFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQA 1100
            K++  R Q  +FG   +   +     VP+IV++CV EIERR +   GIYRV+GV T ++ 
Sbjct: 750  KKLQGRLQ--LFGQDFSHAARSAPDGVPFIVKKCVCEIERRALRTKGIYRVNGVKTRVEK 807

Query: 1101 LKAAFDVNNKDVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNF-----------A 1149
            L  AF+ N K++ V +S+   + I+  LKLY R+LPEPL +   Y              A
Sbjct: 808  LCQAFE-NGKEL-VELSQASPHDISNVLKLYLRQLPEPLISFRLYHELVGLAKDSLKAEA 865

Query: 1150 EGIALSD-----------PVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKM 1198
            E  A S             VA    +  LL  LP  N  +  +LL HL+R+ E E  NKM
Sbjct: 866  EAKAASRGRQDGSESEAVAVALAGRLRELLRDLPPENRASLQYLLRHLRRIVEVEQDNKM 925

Query: 1199 SLHNLATVFGPTLLRPSEKES 1219
            +  NL  VFGPTLLRP   E+
Sbjct: 926  TPGNLGIVFGPTLLRPRPTEA 946



 Score = 32.0 bits (71), Expect = 3.9
 Identities = 24/68 (35%), Positives = 30/68 (44%), Gaps = 6/68 (8%)

Query: 86  GASEPRASASRPQPAPADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAASGERDDR 145
           G+  P+ S   P+   AD   P P+ EP A     GS G    GT +RP  + S      
Sbjct: 22  GSPSPQPSGELPRKDGADAVFPGPSLEPPA-----GSSGVKATGTLKRP-TSLSRHASAA 75

Query: 146 GPPASVAA 153
           G P S AA
Sbjct: 76  GFPLSGAA 83


>gi|5803145 ralA binding protein 1 [Homo sapiens]
          Length = 655

 Score =  107 bits (267), Expect = 7e-23
 Identities = 57/165 (34%), Positives = 91/165 (55%), Gaps = 7/165 (4%)

Query: 1051 VFGVKIAVVTKR----ERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFD 1106
            +FG+ +A   +R    +  ++P + R+C++ +E+ GM+  GIYRVSG+ + +  LKAA+D
Sbjct: 189  IFGIPLADAVERTMMYDGIRLPAVFRECIDYVEKYGMKCEGIYRVSGIKSKVDELKAAYD 248

Query: 1107 VNNKDVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKESCMLN 1166
               ++ S  + + + N +A  LK Y R+LPE L T E  P F E    +    K      
Sbjct: 249  ---REESTNLEDYEPNTVASLLKQYLRDLPENLLTKELMPRFEEACGRTTETEKVQEFQR 305

Query: 1167 LLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTL 1211
            LL  LPE N L   +L+ H+  V  KE   KM++ N++ V  PT+
Sbjct: 306  LLKELPECNYLLISWLIVHMDHVIAKELETKMNIQNISIVLSPTV 350


>gi|58761492 Rho guanine nucleotide exchange factor (GEF) 10-like
           isoform 1 [Homo sapiens]
          Length = 1279

 Score =  105 bits (261), Expect = 4e-22
 Identities = 77/287 (26%), Positives = 127/287 (44%), Gaps = 34/287 (11%)

Query: 498 MRKWVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTSQQIETIFFKVPELYEIH 557
           +R+ +L  I+ SE +Y+  L+ +L   +            L++++ + +FF+V E+   H
Sbjct: 316 VRRHILGSIVQSEGSYVESLKRILQDYR--NPLMEMEPKALSARKCQVVFFRVKEILHCH 373

Query: 558 KEFYDGLFPRVQQWSHQQRVGDLFQKLASQ---LGVYRAFVDNYGVAMEMAEKCCQANAQ 614
             F   L  RV +W   +++GDLF    S+   L VY  +V+N+  AM + +K C     
Sbjct: 374 SMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSAMSIIKKACLTKPA 433

Query: 615 FAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPLL 674
           F E  +  +  S         + +L  L+ KP+ R  +  L+L D+LK+TP  HPD   L
Sbjct: 434 FLEFLKRRQVCS-------PDRVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLSL 486

Query: 675 QDALRISQNFLSSINEE----------------ITPRRQSMTVKKGEHRQLLKDSFMVEL 718
           Q AL   +     +NE+                ++ R     +     RQLL    + E 
Sbjct: 487 QLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLCETLTET 546

Query: 719 VEGAR------KLRHVFLFTDLLLCTKLKKQSGGKTQQYDCKWYIPL 759
           V G R      K R VFL  D+L+C  +  +      Q +    +PL
Sbjct: 547 VYGDRGQLIKSKERRVFLLNDMLVCANINFKPANHRGQLEISSLVPL 593


>gi|74136547 Rho guanine nucleotide exchange factor (GEF) 10-like
           isoform 2 [Homo sapiens]
          Length = 1240

 Score =  105 bits (261), Expect = 4e-22
 Identities = 77/287 (26%), Positives = 127/287 (44%), Gaps = 34/287 (11%)

Query: 498 MRKWVLSGILASEETYLSHLEALLLPMKPLKAAATTSQPVLTSQQIETIFFKVPELYEIH 557
           +R+ +L  I+ SE +Y+  L+ +L   +            L++++ + +FF+V E+   H
Sbjct: 277 VRRHILGSIVQSEGSYVESLKRILQDYR--NPLMEMEPKALSARKCQVVFFRVKEILHCH 334

Query: 558 KEFYDGLFPRVQQWSHQQRVGDLFQKLASQ---LGVYRAFVDNYGVAMEMAEKCCQANAQ 614
             F   L  RV +W   +++GDLF    S+   L VY  +V+N+  AM + +K C     
Sbjct: 335 SMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSAMSIIKKACLTKPA 394

Query: 615 FAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPLL 674
           F E  +  +  S         + +L  L+ KP+ R  +  L+L D+LK+TP  HPD   L
Sbjct: 395 FLEFLKRRQVCS-------PDRVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLSL 447

Query: 675 QDALRISQNFLSSINEE----------------ITPRRQSMTVKKGEHRQLLKDSFMVEL 718
           Q AL   +     +NE+                ++ R     +     RQLL    + E 
Sbjct: 448 QLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLCETLTET 507

Query: 719 VEGAR------KLRHVFLFTDLLLCTKLKKQSGGKTQQYDCKWYIPL 759
           V G R      K R VFL  D+L+C  +  +      Q +    +PL
Sbjct: 508 VYGDRGQLIKSKERRVFLLNDMLVCANINFKPANHRGQLEISSLVPL 554


>gi|150417981 glucocorticoid receptor DNA binding factor 1 [Homo
            sapiens]
          Length = 1499

 Score =  103 bits (257), Expect = 1e-21
 Identities = 66/239 (27%), Positives = 117/239 (48%), Gaps = 13/239 (5%)

Query: 1030 SVKFNSREFSLKRMPSRK----QTGVFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEE 1085
            S++ N+++   K  PS      ++  FGV +  V   E+  +P  + +C+E IE  G+  
Sbjct: 1221 SLRRNTKKPKPKPRPSITKATWESNYFGVPLTTVVTPEKP-IPIFIERCIEYIEATGLST 1279

Query: 1086 VGIYRVSGVATDIQALKAAFDVNNKDVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFY 1145
             GIYRVSG  +++++L+  FD ++ ++ +   +  VN +AG +K +F ELP+PL      
Sbjct: 1280 EGIYRVSGNKSEMESLQRQFDQDH-NLDLAEKDFTVNTVAGAMKSFFSELPDPLVPYNMQ 1338

Query: 1146 PNFAEGIALSDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLAT 1205
             +  E   ++D   K   +  +L   P+ N   F +++ HL +V+    VN M+  NL+ 
Sbjct: 1339 IDLVEAHKINDREQKLHALKEVLKKFPKENHEVFKYVISHLNKVSHNNKVNLMTSENLSI 1398

Query: 1206 VFGPTLLRPSEKESKLPANPSQPITMTDSWSLEVMSQVQVLLYFLQLEAIPAPDSKRQS 1264
             F PTL+RP         +    +T T ++   +   +Q   +F     I  P   R S
Sbjct: 1399 CFWPTLMRPD-------FSTMDALTATRTYQTIIELFIQQCPFFFYNRPITEPPGARPS 1450


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.131    0.381 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 51,554,982
Number of Sequences: 37866
Number of extensions: 2592111
Number of successful extensions: 15355
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 200
Number of HSP's successfully gapped in prelim test: 636
Number of HSP's that attempted gapping in prelim test: 12742
Number of HSP's gapped (non-prelim): 2813
length of query: 1271
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1157
effective length of database: 13,930,794
effective search space: 16117928658
effective search space used: 16117928658
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.