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Search of human proteins with 81295416
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|81295416 sushi domain containing 4 isoform b [Homo sapiens]
(290 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|81295416 sushi domain containing 4 isoform b [Homo sapiens] 619 e-177
gi|148539593 sushi domain containing 4 isoform a [Homo sapiens] 518 e-147
gi|148886654 polydom [Homo sapiens] 86 4e-17
gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo sa... 82 4e-16
gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sap... 74 2e-13
gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sap... 74 2e-13
gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens] 70 2e-12
gi|110611237 coagulation factor XIII B subunit precursor [Homo s... 70 2e-12
gi|62739186 complement factor H isoform a precursor [Homo sapiens] 69 5e-12
gi|13540563 complement factor H-related 5 [Homo sapiens] 69 5e-12
gi|157419154 selectin P precursor [Homo sapiens] 69 6e-12
gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens] 67 2e-11
gi|166235140 seizure related 6 homolog (mouse)-like 2 isoform 4 ... 66 4e-11
gi|166235138 seizure related 6 homolog (mouse)-like 2 isoform 3 ... 66 4e-11
gi|166235136 seizure related 6 homolog (mouse)-like 2 isoform 2 ... 66 4e-11
gi|6912612 seizure related 6 homolog (mouse)-like 2 isoform 1 [H... 66 4e-11
gi|117320518 complement factor H-related 4 [Homo sapiens] 64 2e-10
gi|62739188 complement factor H isoform b precursor [Homo sapiens] 62 5e-10
gi|4502503 complement component 4 binding protein, alpha chain p... 62 6e-10
gi|42544177 complement component (3d/Epstein Barr virus) recepto... 62 8e-10
gi|54792123 complement component (3d/Epstein Barr virus) recepto... 62 8e-10
gi|187960042 selectin E precursor [Homo sapiens] 60 2e-09
gi|148922949 complement component (3b/4b) receptor 1-like [Homo ... 60 3e-09
gi|86793109 complement receptor 1 isoform S precursor [Homo sapi... 57 1e-08
gi|86793036 complement receptor 1 isoform F precursor [Homo sapi... 57 1e-08
gi|27502411 CD46 antigen, complement regulatory protein isoform ... 54 2e-07
gi|27502409 CD46 antigen, complement regulatory protein isoform ... 54 2e-07
gi|27502405 CD46 antigen, complement regulatory protein isoform ... 54 2e-07
gi|118442839 complement factor H-related 1 [Homo sapiens] 53 4e-07
gi|239758113 PREDICTED: similar to complement factor H-related 1... 53 4e-07
>gi|81295416 sushi domain containing 4 isoform b [Homo sapiens]
Length = 290
Score = 619 bits (1596), Expect = e-177
Identities = 290/290 (100%), Positives = 290/290 (100%)
Query: 1 MYHGMNPSNGDGFLEQQQQQQQPQSPQRLLAVILWFQLALCFGPAQLTGGFDDLQVCADP 60
MYHGMNPSNGDGFLEQQQQQQQPQSPQRLLAVILWFQLALCFGPAQLTGGFDDLQVCADP
Sbjct: 1 MYHGMNPSNGDGFLEQQQQQQQPQSPQRLLAVILWFQLALCFGPAQLTGGFDDLQVCADP 60
Query: 61 GIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQE 120
GIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQE
Sbjct: 61 GIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQE 120
Query: 121 DCRIPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNLPICQGC 180
DCRIPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNLPICQGC
Sbjct: 121 DCRIPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNLPICQGC 180
Query: 181 LRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLAL 240
LRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLAL
Sbjct: 181 LRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLAL 240
Query: 241 EGGRPEHLFPVLYFPHIRLAAAVLYFCPVLKSSPTPAPTCSSTSTTTSLF 290
EGGRPEHLFPVLYFPHIRLAAAVLYFCPVLKSSPTPAPTCSSTSTTTSLF
Sbjct: 241 EGGRPEHLFPVLYFPHIRLAAAVLYFCPVLKSSPTPAPTCSSTSTTTSLF 290
>gi|148539593 sushi domain containing 4 isoform a [Homo sapiens]
Length = 490
Score = 518 bits (1333), Expect = e-147
Identities = 241/241 (100%), Positives = 241/241 (100%)
Query: 1 MYHGMNPSNGDGFLEQQQQQQQPQSPQRLLAVILWFQLALCFGPAQLTGGFDDLQVCADP 60
MYHGMNPSNGDGFLEQQQQQQQPQSPQRLLAVILWFQLALCFGPAQLTGGFDDLQVCADP
Sbjct: 1 MYHGMNPSNGDGFLEQQQQQQQPQSPQRLLAVILWFQLALCFGPAQLTGGFDDLQVCADP 60
Query: 61 GIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQE 120
GIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQE
Sbjct: 61 GIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQE 120
Query: 121 DCRIPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNLPICQGC 180
DCRIPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNLPICQGC
Sbjct: 121 DCRIPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNLPICQGC 180
Query: 181 LRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLAL 240
LRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLAL
Sbjct: 181 LRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLAL 240
Query: 241 E 241
E
Sbjct: 241 E 241
>gi|148886654 polydom [Homo sapiens]
Length = 3571
Score = 85.9 bits (211), Expect = 4e-17
Identities = 62/194 (31%), Positives = 88/194 (45%), Gaps = 21/194 (10%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C+ P + NG G + + C +GF L+GA R+CL NG+ D
Sbjct: 2833 CSSPPVSANG--QVRGDEYTFQKEIEYTCNEGFLLEGARSRVCLA--NGSWSGATPD--- 2885
Query: 117 CVQEDCRIP-QIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSL-CRDDGTWN-N 173
CV C P Q+ + Y +++ CHEG+ LH L C+ DG W+
Sbjct: 2886 CVPVRCATPPQLANGVTEGLDYGFMKEVTFHCHEGYI-----LHGAPKLTCQSDGNWDAE 2940
Query: 174 LPICQ--GCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWS 231
+P+C+ C P ++G+ N SF G I Y+CFPG+KL G++ CL N WS
Sbjct: 2941 IPLCKPVNCGPPEDLAHGFPN----GFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWS 2996
Query: 232 SSPPRCLALEGGRP 245
S P CL P
Sbjct: 2997 GSSPSCLPCRCSTP 3010
Score = 79.7 bits (195), Expect = 3e-15
Identities = 57/195 (29%), Positives = 90/195 (46%), Gaps = 23/195 (11%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLK--HFNGTLGWIPSDN 114
C PG PENG SG ++ G+ F CQ+G++L G TK CL+ +N + +
Sbjct: 1789 CKAPGNPENGHS--SGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPY----- 1841
Query: 115 SICVQEDCRIPQI-EDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNN 173
C C P I E+ I + G K+ C++G+ + + S C + +W++
Sbjct: 1842 --CKAVSCGKPAIPENGCIEELAFTFGSKVTYRCNKGYTLA----GDKESSCLANSSWSH 1895
Query: 174 LP-ICQG--CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIW 230
P +C+ C P +NG +S L + SY C G+ L G + +EC + IW
Sbjct: 1896 SPPVCEPVKCSSPENINNGKYILSGLTYL----STASYSCDTGYSLQGPSIIECTASGIW 1951
Query: 231 SSSPPRCLALEGGRP 245
+PP C + G P
Sbjct: 1952 DRAPPACHLVFCGEP 1966
Score = 77.8 bits (190), Expect = 1e-14
Identities = 56/196 (28%), Positives = 86/196 (43%), Gaps = 20/196 (10%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C P NG G + S A + C+ GF+L G T LC G G
Sbjct: 2440 CPQPEEIPNGIIDVQGLAYL--STALYTCKPGFELVGNTTTLC-----GENGHWLGGKPT 2492
Query: 117 CVQEDCRIP-QIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWN-NL 174
C +C P +I + + +G+ + +C+ GF++ P C + G W+ +
Sbjct: 2493 CKAIECLKPKEILNGKFSYTDLHYGQTVTYSCNRGFRLEGPS----ALTCLETGDWDVDA 2548
Query: 175 PICQG--CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSS 232
P C C P NG+V ++ + G +I Y CFPGF++ G A C + WSS
Sbjct: 2549 PSCNAIHCDSPQPIENGFVEGAD----YSYGAIIIYSCFPGFQVAGHAMQTC-EESGWSS 2603
Query: 233 SPPRCLALEGGRPEHL 248
S P C+ ++ G P H+
Sbjct: 2604 SIPTCMPIDCGLPPHI 2619
Score = 77.0 bits (188), Expect = 2e-14
Identities = 64/240 (26%), Positives = 107/240 (44%), Gaps = 20/240 (8%)
Query: 56 VCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNS 115
+C P + G PS + F GS ++ C GF L+G + LC +GT W S
Sbjct: 2380 LCTPPPLISFGVPIPSSALHF-GSTVKYSCVGGFFLRGNSTTLCQP--DGT--W-SSPLP 2433
Query: 116 ICVQEDCRIPQ-IEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTW-NN 173
CV +C P+ I + I + + + TC GF++ + N +LC ++G W
Sbjct: 2434 ECVPVECPQPEEIPNGIIDVQGLAYLSTALYTCKPGFEL----VGNTTTLCGENGHWLGG 2489
Query: 174 LPICQG--CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWS 231
P C+ CL+P NG + ++L G ++Y C GF+L+G + L CL+ W
Sbjct: 2490 KPTCKAIECLKPKEILNGKFSYTDLH----YGQTVTYSCNRGFRLEGPSALTCLETGDWD 2545
Query: 232 SSPPRCLALEGGRPEHL-FPVLYFPHIRLAAAVLYFC-PVLKSSPTPAPTCSSTSTTTSL 289
P C A+ P+ + + A ++Y C P + + TC + ++S+
Sbjct: 2546 VDAPSCNAIHCDSPQPIENGFVEGADYSYGAIIIYSCFPGFQVAGHAMQTCEESGWSSSI 2605
Score = 76.6 bits (187), Expect = 2e-14
Identities = 59/232 (25%), Positives = 97/232 (41%), Gaps = 50/232 (21%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKH--FNGT-------- 106
C P ENGF S F+ GS + C +G+ L G ++ C + +NG
Sbjct: 1690 CGVPPPLENGFH--SADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVD 1747
Query: 107 ---LGWIPSDNSICVQED-----------------------CRIP-QIEDAEIHNKTYRH 139
+G S+++ C+ D C+ P E+ + Y
Sbjct: 1748 ECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEIYTV 1807
Query: 140 GEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNL-PICQG--CLRPLASSNGYVNISEL 196
G ++ +C EG+++ + C + G WN+L P C+ C +P NG +
Sbjct: 1808 GAEVTFSCQEGYQL----MGVTKITCLESGEWNHLIPYCKAVSCGKPAIPENGCIE---- 1859
Query: 197 QTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLALEGGRPEHL 248
+ +F G+ ++YRC G+ L G CL N WS SPP C ++ PE++
Sbjct: 1860 ELAFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKCSSPENI 1911
Score = 76.3 bits (186), Expect = 3e-14
Identities = 61/239 (25%), Positives = 93/239 (38%), Gaps = 66/239 (27%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C P ENGF G + G++ + C GF++ G + C + GW S
Sbjct: 2556 CDSPQPIENGF--VEGADYSYGAIIIYSCFPGFQVAGHAMQTCEES-----GW-SSSIPT 2607
Query: 117 CVQEDCRIPQI-----------------------------------------------ED 129
C+ DC +P E
Sbjct: 2608 CMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPHPPYHLGAVAKTWENTKES 2667
Query: 130 AEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWN-NLPICQG--CLRPLAS 186
H+ + +G + TC+ G+++ L N V +C++DGTWN + P C C P A
Sbjct: 2668 PATHSSNFLYGTMVSYTCNPGYEL----LGNPVLICQEDGTWNGSAPSCISIECDLPTAP 2723
Query: 187 SNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLALEGGRP 245
NG++ +E +G+ + Y C PG L GS CL+N WS + PRC A+ +P
Sbjct: 2724 ENGFLRFTETS----MGSAVQYSCKPGHILAGSDLRLCLENRKWSGASPRCEAISCKKP 2778
Score = 75.1 bits (183), Expect = 7e-14
Identities = 59/192 (30%), Positives = 86/192 (44%), Gaps = 18/192 (9%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C P +GF P+G F G ++ C G+KL G + R CL NG+ W S S
Sbjct: 2949 CGPPEDLAHGF--PNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLS--NGS--WSGSSPS- 3001
Query: 117 CVQEDCRIPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNN-LP 175
C+ C P IE ++ + G+ I C +GFK+ L C DG W++ P
Sbjct: 3002 CLPCRCSTPVIEYGTVNGTDFDCGKAARIQCFKGFKL----LGLSEITCEADGQWSSGFP 3057
Query: 176 ICQ--GCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSS 233
C+ C N +++ +TS VI+Y C G+ + GS+ L C + +WS
Sbjct: 3058 HCEHTSCGSLPMIPNAFIS----ETSSWKENVITYSCRSGYVIQGSSDLICTEKGVWSQP 3113
Query: 234 PPRCLALEGGRP 245
P C L G P
Sbjct: 3114 YPVCEPLSCGSP 3125
Score = 73.9 bits (180), Expect = 2e-13
Identities = 57/192 (29%), Positives = 83/192 (43%), Gaps = 17/192 (8%)
Query: 60 PGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI-CV 118
P + + + S F GSV F C +GF L + K C++ W PS SI C+
Sbjct: 2087 PSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQ----WNPSPMSIQCI 2142
Query: 119 QEDC-RIPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNN-LPI 176
C P I + Y G + +C++GF I+ S C G W++ +P
Sbjct: 2143 PVRCGEPPSIMNGYASGSNYSFGAMVAYSCNKGFYIK----GEKKSTCEATGQWSSPIPT 2198
Query: 177 CQ--GCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIW-SSS 233
C C P NG++ E T + + Y+C PG+K GS C N W S S
Sbjct: 2199 CHPVSCGEPPKVENGFL---EHTTGRIFESEVRYQCNPGYKSVGSPVFVCQANRHWHSES 2255
Query: 234 PPRCLALEGGRP 245
P C+ L+ G+P
Sbjct: 2256 PLMCVPLDCGKP 2267
Score = 70.9 bits (172), Expect = 1e-12
Identities = 65/235 (27%), Positives = 105/235 (44%), Gaps = 23/235 (9%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C +P ENGF + G FE V R+ C G+K G+ +C + + W +
Sbjct: 2204 CGEPPKVENGFLEHTTGRIFESEV-RYQCNPGYKSVGSPVFVCQANRH----WHSESPLM 2258
Query: 117 CVQEDC-RIPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNL- 174
CV DC + P I++ + + + G K+ C+EG+++ + + C+ G WN
Sbjct: 2259 CVPLDCGKPPPIQNGFMKGENFEVGSKVQFFCNEGYEL----VGDSSWTCQKSGKWNKKS 2314
Query: 175 -PICQG--CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWS 231
P C C P N V + EL T VG V+++ C G L G + L+CL + W+
Sbjct: 2315 NPKCMPAKCPEPPLLENQLV-LKELTTE--VG-VVTFSCKEGHVLQGPSVLKCLPSQQWN 2370
Query: 232 SSPPRCLALEGGRPEHLFPVLYFPHIRLAAAVLYFCPVLKSSPTPAPTCSSTSTT 286
S P C + P P++ F + + ++ L+F +K S STT
Sbjct: 2371 DSFPVCKIVLCTPP----PLISF-GVPIPSSALHFGSTVKYSCVGGFFLRGNSTT 2420
Score = 69.7 bits (169), Expect = 3e-12
Identities = 59/199 (29%), Positives = 83/199 (41%), Gaps = 25/199 (12%)
Query: 57 CADPGIPENGFRTPSGGVFFE---GSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSD 113
C P PENGF F E GS ++ C+ G L G+ RLCL++ + G P
Sbjct: 2717 CDLPTAPENGFLR-----FTETSMGSAVQYSCKPGHILAGSDLRLCLENRKWS-GASPR- 2769
Query: 114 NSICVQEDCRIPQ-IEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWN 172
C C+ P + + I Y + L C G+ + + C+DD W+
Sbjct: 2770 ---CEAISCKKPNPVMNGSIKGSNYTYLSTLYYECDPGYVLNGTERRT----CQDDKNWD 2822
Query: 173 -NLPIC--QGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLI 229
+ PIC C P S+NG V E + I Y C GF L+G+ CL N
Sbjct: 2823 EDEPICIPVDCSSPPVSANGQVRGDE----YTFQKEIEYTCNEGFLLEGARSRVCLANGS 2878
Query: 230 WSSSPPRCLALEGGRPEHL 248
WS + P C+ + P L
Sbjct: 2879 WSGATPDCVPVRCATPPQL 2897
Score = 68.9 bits (167), Expect = 5e-12
Identities = 53/199 (26%), Positives = 95/199 (47%), Gaps = 24/199 (12%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C P PE+GF S F S + C+ G++L+G +R+C ++ + G +I
Sbjct: 3241 CGKPESPEHGFVVGSKYTF--ESTIIYQCEPGYELEGNRERVCQENRQWSGGV-----AI 3293
Query: 117 CVQEDCRIPQIE----DAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWN 172
C + C P +E A+I N+T G ++ +C+ G+ + P + C ++GTW+
Sbjct: 3294 CKETRCETP-LEFLNGKADIENRTT--GPNVVYSCNRGYSLEGPSEAH----CTENGTWS 3346
Query: 173 N-LPICQG--CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLI 229
+ +P+C+ C P + +SE + F V +S +C GF L G + C +
Sbjct: 3347 HPVPLCKPNPCPVPFVIPENAL-LSEKE--FYVDQNVSIKCREGFLLQGHGIITCNPDET 3403
Query: 230 WSSSPPRCLALEGGRPEHL 248
W+ + +C + G P H+
Sbjct: 3404 WTQTSAKCEKISCGPPAHV 3422
Score = 65.5 bits (158), Expect = 5e-11
Identities = 61/241 (25%), Positives = 96/241 (39%), Gaps = 65/241 (26%)
Query: 78 GSVARFHCQDGFKLKGATKRLCLKHFNGTLGW---IPSDNSICVQEDCRIPQ-IEDAEIH 133
G + C GF+L+G + CL+ T W PS N+I C PQ IE+ +
Sbjct: 2517 GQTVTYSCNRGFRLEGPSALTCLE----TGDWDVDAPSCNAI----HCDSPQPIENGFVE 2568
Query: 134 NKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNLPICQ------------GCL 181
Y +G +I +C GF++ + + C + G +++P C G
Sbjct: 2569 GADYSYGAIIIYSCFPGFQVA----GHAMQTCEESGWSSSIPTCMPIDCGLPPHIDFGDC 2624
Query: 182 RPLASSNGYV----------------------------NISEL----QTSFPVGTVISYR 209
L GY N E ++F GT++SY
Sbjct: 2625 TKLKDDQGYFEQEDDMMEVPYVTPHPPYHLGAVAKTWENTKESPATHSSNFLYGTMVSYT 2684
Query: 210 CFPGFKLDGSAYLECLQNLIWSSSPPRCLALE---GGRPEHLFPVLYFPHIRLAAAVLYF 266
C PG++L G+ L C ++ W+ S P C+++E PE+ F L F + +AV Y
Sbjct: 2685 CNPGYELLGNPVLICQEDGTWNGSAPSCISIECDLPTAPENGF--LRFTETSMGSAVQYS 2742
Query: 267 C 267
C
Sbjct: 2743 C 2743
Score = 62.4 bits (150), Expect = 5e-10
Identities = 53/202 (26%), Positives = 85/202 (42%), Gaps = 22/202 (10%)
Query: 54 LQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSD 113
L C +P ++ T G F + + C++G+ L G CL W SD
Sbjct: 1960 LVFCGEPPAIKDAVIT--GNNFTFRNTVTYTCKEGYTLAGLDTIECLADGK----WSRSD 2013
Query: 114 NSICVQEDCRIPQIEDAEIHNKTYR-HGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTW- 171
C+ C P I D +R G+ C +G+ + N LC G W
Sbjct: 2014 QQ-CLAVSCDEPPIVDHASPETAHRLFGDIAFYYCSDGYSLA----DNSQLLCNAQGKWV 2068
Query: 172 ----NNLPICQG--CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECL 225
++P C C +P + S + S + F G+V+S++C GF L+ SA +EC+
Sbjct: 2069 PPEGQDMPRCIAHFCEKPPSVSYSILE-SVSKAKFAAGSVVSFKCMEGFVLNTSAKIECM 2127
Query: 226 QNLIWSSSPP--RCLALEGGRP 245
+ W+ SP +C+ + G P
Sbjct: 2128 RGGQWNPSPMSIQCIPVRCGEP 2149
Score = 61.2 bits (147), Expect = 1e-09
Identities = 60/247 (24%), Positives = 93/247 (37%), Gaps = 41/247 (16%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIP---SD 113
C +P I ++ + +F G +A ++C DG+ L ++ LC N W+P D
Sbjct: 2021 CDEPPIVDHASPETAHRLF--GDIAFYYCSDGYSLADNSQLLC----NAQGKWVPPEGQD 2074
Query: 114 NSICVQEDCRIPQIEDAEIHNKT----YRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDG 169
C+ C P I + G + C EGF + + C G
Sbjct: 2075 MPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNT----SAKIECMRGG 2130
Query: 170 TWNNLPICQGCL-----RPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLEC 224
WN P+ C+ P + NGY + S ++ G +++Y C GF + G C
Sbjct: 2131 QWNPSPMSIQCIPVRCGEPPSIMNGYASGS----NYSFGAMVAYSCNKGFYIKGEKKSTC 2186
Query: 225 LQNLIWSSSPPRCLALEGGRP--------EHLFPVLYFPHIRLAAAVLYFC-PVLKSSPT 275
WSS P C + G P EH ++ +R Y C P KS +
Sbjct: 2187 EATGQWSSPIPTCHPVSCGEPPKVENGFLEHTTGRIFESEVR------YQCNPGYKSVGS 2240
Query: 276 PAPTCSS 282
P C +
Sbjct: 2241 PVFVCQA 2247
Score = 59.7 bits (143), Expect = 3e-09
Identities = 48/196 (24%), Positives = 76/196 (38%), Gaps = 19/196 (9%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C P NG S + S + C G+ L G +R C N W D I
Sbjct: 2775 CKKPNPVMNGSIKGSNYTYL--STLYYECDPGYVLNGTERRTCQDDKN----W-DEDEPI 2827
Query: 117 CVQEDCRIPQIE-DAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNL- 174
C+ DC P + + ++ Y +++ TC+EGF + +C +G+W+
Sbjct: 2828 CIPVDCSSPPVSANGQVRGDEYTFQKEIEYTCNEGFLLEGARSR----VCLANGSWSGAT 2883
Query: 175 PICQG--CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSS 232
P C C P +NG + +++ C G+ L G+ L C + W +
Sbjct: 2884 PDCVPVRCATPPQLANGVTE----GLDYGFMKEVTFHCHEGYILHGAPKLTCQSDGNWDA 2939
Query: 233 SPPRCLALEGGRPEHL 248
P C + G PE L
Sbjct: 2940 EIPLCKPVNCGPPEDL 2955
Score = 58.2 bits (139), Expect = 9e-09
Identities = 45/164 (27%), Positives = 75/164 (45%), Gaps = 21/164 (12%)
Query: 83 FHCQDGFKLKGATKRLCLKHFNGTLGW-IPSDNSICVQEDCRIPQI--EDAEIHNKTYRH 139
+ C G+ L+G ++ C + NGT +P +C C +P + E+A + K +
Sbjct: 3323 YSCNRGYSLEGPSEAHCTE--NGTWSHPVP----LCKPNPCPVPFVIPENALLSEKEFYV 3376
Query: 140 GEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNLPI-CQ--GCLRPLASSNGYVNISEL 196
+ + I C EGF ++ H +++ C D TW C+ C P N
Sbjct: 3377 DQNVSIKCREGFLLQG---HGIIT-CNPDETWTQTSAKCEKISCGPPAHVENAIAR---- 3428
Query: 197 QTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLAL 240
+ G +I+Y C+ G+ L+G CL+N W +SPP C A+
Sbjct: 3429 GVHYQYGDMITYSCYSGYMLEGFLRSVCLENGTW-TSPPICRAV 3471
Score = 53.5 bits (127), Expect = 2e-07
Identities = 44/188 (23%), Positives = 78/188 (41%), Gaps = 22/188 (11%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRL-CLKHFNGTLGWIPSDNS 115
C P N T + S + C +G+ + T C K W P S
Sbjct: 3122 CGSPPSVANAVATGEAHTY--ESEVKLRCLEGYTMDTDTDTFTCQKDGR----WFPERIS 3175
Query: 116 ICVQEDCRIPQ-IEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWN-- 172
C + C +P+ I +H + ++ ++C EG+ + +S+C+ DGTW
Sbjct: 3176 -CSPKKCPLPENITHILVHGDDFSVNRQVSVSCAEGYTFEGVN----ISVCQLDGTWEPP 3230
Query: 173 -NLPICQ--GCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLI 229
+ C C +P + +G+V + + + + I Y+C PG++L+G+ C +N
Sbjct: 3231 FSDESCSPVSCGKPESPEHGFV----VGSKYTFESTIIYQCEPGYELEGNRERVCQENRQ 3286
Query: 230 WSSSPPRC 237
WS C
Sbjct: 3287 WSGGVAIC 3294
Score = 44.3 bits (103), Expect = 1e-04
Identities = 31/122 (25%), Positives = 56/122 (45%), Gaps = 12/122 (9%)
Query: 62 IPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQED 121
IPEN + F+ C++GF L+G C N W + ++ C +
Sbjct: 3363 IPENALLSEKE--FYVDQNVSIKCREGFLLQGHGIITC----NPDETWTQT-SAKCEKIS 3415
Query: 122 CRIP-QIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNLPICQGC 180
C P +E+A Y++G+ + +C+ G+ + + S+C ++GTW + PIC+
Sbjct: 3416 CGPPAHVENAIARGVHYQYGDMITYSCYSGYMLE----GFLRSVCLENGTWTSPPICRAV 3471
Query: 181 LR 182
R
Sbjct: 3472 CR 3473
Score = 43.5 bits (101), Expect = 2e-04
Identities = 46/213 (21%), Positives = 78/213 (36%), Gaps = 58/213 (27%)
Query: 78 GSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDCRIPQIEDAEIHN-KT 136
GS C GF+L G + CL T +P C + C +P + H+
Sbjct: 1651 GSKVNLFCDPGFQLVGNPVQYCLNQGQWTQP-LPH----CERISCGVPPPLENGFHSADD 1705
Query: 137 YRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNL-PIC------------------ 177
+ G + C+ G+ + L + C D+G+WN + P C
Sbjct: 1706 FYAGSTVTYQCNNGYYL----LGDSRMFCTDNGSWNGVSPSCLDVDECAVGSDCSEHASC 1761
Query: 178 -------------------QGCLRPLA------SSNGYVNISELQTSFPVGTVISYRCFP 212
+ C P+ NG+ + E+ T VG +++ C
Sbjct: 1762 LNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGH-SSGEIYT---VGAEVTFSCQE 1817
Query: 213 GFKLDGSAYLECLQNLIWSSSPPRCLALEGGRP 245
G++L G + CL++ W+ P C A+ G+P
Sbjct: 1818 GYQLMGVTKITCLESGEWNHLIPYCKAVSCGKP 1850
Score = 43.1 bits (100), Expect = 3e-04
Identities = 43/204 (21%), Positives = 73/204 (35%), Gaps = 44/204 (21%)
Query: 42 FGPAQLTGGFDDLQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRL--- 98
+ P GG C P+ +P G E V C++G++ G T L
Sbjct: 328 YKPEGSPGGISSCIPC-----PDENHTSPPGSTSPEDCV----CREGYRASGQTCELVHC 378
Query: 99 -CLKHFNGTLGWIPSDNSICVQEDCRIPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPD 157
LK P +N +Q C + CH GF +
Sbjct: 379 PALK---------PPENGYFIQNTCN-------------NHFNAACGVRCHPGFDL---- 412
Query: 158 LHNMVSLCRDDGTWNNLPI---CQGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGF 214
+ + + LC +G W+ + C +G+++ S + + +++ C G+
Sbjct: 413 VGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVA--CDEGY 470
Query: 215 KLDGSAYLECLQNLIWSSSPPRCL 238
+L+GS L C N W PRC+
Sbjct: 471 RLEGSDKLTCQGNSQWDGPEPRCV 494
Score = 31.2 bits (69), Expect = 1.1
Identities = 15/46 (32%), Positives = 22/46 (47%)
Query: 203 GTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLALEGGRPEHL 248
G+ ++ C PGF+L G+ CL W+ P C + G P L
Sbjct: 1651 GSKVNLFCDPGFQLVGNPVQYCLNQGQWTQPLPHCERISCGVPPPL 1696
>gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo
sapiens]
Length = 3538
Score = 82.4 bits (202), Expect = 4e-16
Identities = 65/197 (32%), Positives = 92/197 (46%), Gaps = 16/197 (8%)
Query: 57 CADPGIPENGFR-TPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNS 115
C+ P P +G+ + +GG SV R+ C GF+L G + +C K G W +
Sbjct: 2465 CSTPESPPHGYIISQTGGQL--NSVVRWACDRGFRLVGKSSAVCRKSSYGYHAW-DAPVP 2521
Query: 116 ICVQEDCRIPQIE-DAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNN- 173
C C IP+ + I Y G ++ C++G+++ +L V C+ DGTW+N
Sbjct: 2522 ACQAISCGIPKAPTNGGILTTDYLVGTRVTYFCNDGYRLSSKELTTAV--CQSDGTWSNH 2579
Query: 174 --LPICQ--GCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLI 229
P C C NG N QTS+ G+ + C GF L GSA ECL + +
Sbjct: 2580 NKTPRCVVISCGELPTPPNG--NKIGTQTSY--GSTAIFTCDLGFMLVGSAVRECLSSGL 2635
Query: 230 WSSSPPRCLALEGGRPE 246
WS S RCLA G PE
Sbjct: 2636 WSESETRCLAGHCGIPE 2652
Score = 73.6 bits (179), Expect = 2e-13
Identities = 60/194 (30%), Positives = 85/194 (43%), Gaps = 18/194 (9%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTL-GWIPSDNS 115
C +PG NG G F SV + C +G+ L G + R C NGT G +P+
Sbjct: 2945 CGNPGTTANGKVFRIDGTTFSSSVI-YSCMEGYILSGPSVRQCTA--NGTWSGTLPN--- 2998
Query: 116 ICVQEDCRIPQIEDAEI-HNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNN- 173
C C P I + + Y G+ + C G+ + + + C +GTW+
Sbjct: 2999 -CTIISCGDPGIPANGLRYGDDYVVGQNVSYMCQPGYTMELNG--SRIRTCTINGTWSGV 3055
Query: 174 LPICQG--CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWS 231
+P C+ C P SNG + T+F G ISY C PG++L A L C+ N WS
Sbjct: 3056 MPTCRAVTCPTPPQISNGRLE----GTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWS 3111
Query: 232 SSPPRCLALEGGRP 245
P+CL G P
Sbjct: 3112 GEVPQCLPKFCGDP 3125
Score = 68.9 bits (167), Expect = 5e-12
Identities = 61/207 (29%), Positives = 85/207 (41%), Gaps = 28/207 (13%)
Query: 52 DDLQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIP 111
D C DPG P +G R S F S R+ C G+ L G+ +R CL + + T G P
Sbjct: 2882 DATGTCGDPGTPGHGSRQESN--FRTKSTVRYACDTGYILHGSEERTCLANGSWT-GRQP 2938
Query: 112 SDNSICVQEDCRIPQIEDAEIHNKTYR-----HGEKLIITCHEGFKIRYPDLHNMVSLCR 166
C C P + K +R +I +C EG+ + P + C
Sbjct: 2939 E----CKAVQCGNP---GTTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQ----CT 2987
Query: 167 DDGTWNN-LPICQ--GCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGF--KLDGSAY 221
+GTW+ LP C C P +NG + VG +SY C PG+ +L+GS
Sbjct: 2988 ANGTWSGTLPNCTIISCGDPGIPANGL----RYGDDYVVGQNVSYMCQPGYTMELNGSRI 3043
Query: 222 LECLQNLIWSSSPPRCLALEGGRPEHL 248
C N WS P C A+ P +
Sbjct: 3044 RTCTINGTWSGVMPTCRAVTCPTPPQI 3070
Score = 65.1 bits (157), Expect = 7e-11
Identities = 53/198 (26%), Positives = 83/198 (41%), Gaps = 22/198 (11%)
Query: 57 CADPGIPENGFRTPS--GGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDN 114
C+DPGIP N R G F G+V + C G+ L G++ +C + G
Sbjct: 2764 CSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPN-----GQWDKPL 2818
Query: 115 SICVQEDCRIPQIE-DAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWN- 172
C+ DC P + +A + + Y G + +C + L C+ +G W+
Sbjct: 2819 PECIMIDCGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSL----LGQSSRTCQLNGHWSG 2874
Query: 173 NLPICQG-----CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQN 227
+ P C G C P +G S +++F + + Y C G+ L GS CL N
Sbjct: 2875 SQPHCSGDATGTCGDPGTPGHG----SRQESNFRTKSTVRYACDTGYILHGSEERTCLAN 2930
Query: 228 LIWSSSPPRCLALEGGRP 245
W+ P C A++ G P
Sbjct: 2931 GSWTGRQPECKAVQCGNP 2948
Score = 64.7 bits (156), Expect = 9e-11
Identities = 47/170 (27%), Positives = 81/170 (47%), Gaps = 19/170 (11%)
Query: 83 FHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDCRIPQIEDAEIHNKTYRHG-- 140
+ C GF+L G++ R+C + N + G +PS CV C P + I+ +T +G
Sbjct: 2672 YQCNPGFRLIGSSVRICQQDHNWS-GQLPS----CVPVSCGHP---GSPIYGRTSGNGFN 2723
Query: 141 --EKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNLP-ICQ--GCLRPLASSNGYVNISE 195
+ + +C+ G+ ++ P + C+ + W++ P +C+ C P +N
Sbjct: 2724 FNDVVTFSCNIGYLMQGPTK----AQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKI 2779
Query: 196 LQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLALEGGRP 245
+F GTV+ Y C PG+ L GS+ L C N W P C+ ++ G P
Sbjct: 2780 EHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGHP 2829
Score = 64.3 bits (155), Expect = 1e-10
Identities = 42/125 (33%), Positives = 60/125 (48%), Gaps = 12/125 (9%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C +PG+P +G + + G F GSV +FHC+ G L+G+T R CL + G P
Sbjct: 3183 CENPGVPRHGSQNNTFG-FQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWS-GIQPE---- 3236
Query: 117 CVQEDCRIPQIEDAE--IHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTW-NN 173
C+ C+ P+ + HG LI TC GF + H +CR D TW
Sbjct: 3237 CIPHSCKQPETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHR---VCRSDNTWTGK 3293
Query: 174 LPICQ 178
+PIC+
Sbjct: 3294 VPICE 3298
Score = 57.8 bits (138), Expect = 1e-08
Identities = 59/253 (23%), Positives = 86/253 (33%), Gaps = 73/253 (28%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGF--KLKGATKRLCLKHFNGTL-GWIPSD 113
C DPGIP NG R G + G + CQ G+ +L G+ R C NGT G +P+
Sbjct: 3004 CGDPGIPANGLRY--GDDYVVGQNVSYMCQPGYTMELNGSRIRTCT--INGTWSGVMPTC 3059
Query: 114 NSICVQEDCRIPQIEDAEIHNKTY------------------------------------ 137
++ PQI + + +
Sbjct: 3060 RAVTCPTP---PQISNGRLEGTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQ 3116
Query: 138 ----------------RHGEKLIITCHEGFKIRYPDL--HNMVSLCRDDGTWNNL----- 174
R G+ I F +P + + +C+ DGTW+
Sbjct: 3117 CLPKFCGDPGIPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCI 3176
Query: 175 -PICQGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSS 233
P C P +G N + F VG+V+ + C G L GS CL +L WS
Sbjct: 3177 EPTQTSCENPGVPRHGSQNNT---FGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGI 3233
Query: 234 PPRCLALEGGRPE 246
P C+ +PE
Sbjct: 3234 QPECIPHSCKQPE 3246
Score = 55.1 bits (131), Expect = 7e-08
Identities = 48/194 (24%), Positives = 76/194 (39%), Gaps = 17/194 (8%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C P P NG + + G+ + C DG++L + +GT W + +
Sbjct: 2528 CGIPKAPTNGGILTTD--YLVGTRVTYFCNDGYRLSSKELTTAVCQSDGT--WSNHNKTP 2583
Query: 117 -CVQEDC-RIPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNL 174
CV C +P + +G I TC GF + + + V C G W+
Sbjct: 2584 RCVVISCGELPTPPNGNKIGTQTSYGSTAIFTCDLGFML----VGSAVRECLSSGLWSES 2639
Query: 175 P---ICQGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWS 231
+ C P NG V + ++ + Y+C PGF+L GS+ C Q+ WS
Sbjct: 2640 ETRCLAGHCGIPELIVNGQV----IGENYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWS 2695
Query: 232 SSPPRCLALEGGRP 245
P C+ + G P
Sbjct: 2696 GQLPSCVPVSCGHP 2709
Score = 52.4 bits (124), Expect = 5e-07
Identities = 30/80 (37%), Positives = 40/80 (50%), Gaps = 6/80 (7%)
Query: 178 QGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLI--WSSSPP 235
Q C P NG+V + F VG IS+ CFPG+ L G++ L CL + W+ P
Sbjct: 2118 QSCPDPRPFRNGFV----IGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLP 2173
Query: 236 RCLALEGGRPEHLFPVLYFP 255
RC AL GG + +Y P
Sbjct: 2174 RCEALCGGNITAMNGTIYSP 2193
Score = 40.0 bits (92), Expect = 0.002
Identities = 19/48 (39%), Positives = 28/48 (58%), Gaps = 2/48 (4%)
Query: 53 DLQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCL 100
+L+ C DPGIP+ G R G F G F C G++L+G ++ +CL
Sbjct: 1074 NLEPCEDPGIPQYGSRI--GFNFGIGDTLTFSCSSGYRLEGTSEIICL 1119
Score = 38.9 bits (89), Expect = 0.005
Identities = 22/67 (32%), Positives = 30/67 (44%), Gaps = 3/67 (4%)
Query: 56 VCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNS 115
+C DPG PENG R G F GS +F C + + L+GA C + W
Sbjct: 381 LCPDPGEPENGKRI--GSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAW-SDHRP 437
Query: 116 ICVQEDC 122
+C + C
Sbjct: 438 VCKVKTC 444
Score = 38.5 bits (88), Expect = 0.007
Identities = 54/243 (22%), Positives = 86/243 (35%), Gaps = 58/243 (23%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGW---IPSD 113
C DPG NG R G + GS ++C G+ L+G + C+ +G GW +PS
Sbjct: 1597 CFDPGNIMNGTRL--GMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSC 1654
Query: 114 NSICVQEDCRIPQIEDAEIHNKTYRHGEKLI--------ITCHEGFKIRYPDLHNMV--- 162
++ C + + K Y G + F LH++V
Sbjct: 1655 HAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVY 1714
Query: 163 ----------SLCRDDGTWNNLPICQG---CLR-------------------PLASSNGY 190
S + +LP+ G +R P SS
Sbjct: 1715 DGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPRTSSTQC 1774
Query: 191 VNISE------LQTSFPVGTVISYRCFPGFKLDGSAYLEC--LQNLI--WSSSPPRCLAL 240
++ E + F VG+ + + C PG+ L GS + C + N + W+ S P C+
Sbjct: 1775 SSVPEPRFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVP 1834
Query: 241 EGG 243
GG
Sbjct: 1835 CGG 1837
Score = 38.5 bits (88), Expect = 0.007
Identities = 22/78 (28%), Positives = 37/78 (47%), Gaps = 6/78 (7%)
Query: 180 CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLI--WSSSPPRC 237
C P S+G ++ + VG V+S++C G+ L G +++ C+ + W+ P C
Sbjct: 1948 CPEPQTPSSGI----KIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPIC 2003
Query: 238 LALEGGRPEHLFPVLYFP 255
LA GG V+ P
Sbjct: 2004 LAQCGGAMSDFSGVILSP 2021
Score = 38.1 bits (87), Expect = 0.009
Identities = 19/68 (27%), Positives = 37/68 (54%), Gaps = 2/68 (2%)
Query: 194 SELQTSFPVGTVISYRCFPGFKLDGSAYLECL--QNLIWSSSPPRCLALEGGRPEHLFPV 251
S + +F +G +++ C G++L+G++ + CL +WS+ PRC+A G + +
Sbjct: 1088 SRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAECGASATNNEGI 1147
Query: 252 LYFPHIRL 259
L P+ L
Sbjct: 1148 LLSPNYPL 1155
Score = 38.1 bits (87), Expect = 0.009
Identities = 16/44 (36%), Positives = 24/44 (54%), Gaps = 3/44 (6%)
Query: 203 GTVISYRCFPGFKLDGSAYLECLQ---NLIWSSSPPRCLALEGG 243
G + ++C PG++L G + C+Q W SPP C+A GG
Sbjct: 1443 GDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPCGG 1486
Score = 38.1 bits (87), Expect = 0.009
Identities = 18/43 (41%), Positives = 24/43 (55%), Gaps = 2/43 (4%)
Query: 200 FPVGTVISYRCFPGFKLDGSAYLECL--QNLIWSSSPPRCLAL 240
F +G +I Y+C PGF L G+A L C + L +PP C L
Sbjct: 2309 FEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQVL 2351
Score = 37.7 bits (86), Expect = 0.012
Identities = 18/44 (40%), Positives = 25/44 (56%), Gaps = 2/44 (4%)
Query: 203 GTVISYRCFPGFKLDGSAYLECL--QNLIWSSSPPRCLALEGGR 244
G+ I Y C PG+ L GS+ L+C+ + W P C+A GGR
Sbjct: 1270 GSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECGGR 1313
Score = 37.7 bits (86), Expect = 0.012
Identities = 21/62 (33%), Positives = 30/62 (48%), Gaps = 4/62 (6%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C DPG+P NG R G G F C G++L+G + C++ N W PS +
Sbjct: 1424 CRDPGVPMNGTRNGDGRE--PGDTVVFQCDPGYELQGEERITCIQVENRYF-WQPSP-PV 1479
Query: 117 CV 118
C+
Sbjct: 1480 CI 1481
Score = 37.0 bits (84), Expect = 0.020
Identities = 17/48 (35%), Positives = 26/48 (54%), Gaps = 1/48 (2%)
Query: 53 DLQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCL 100
+L C DPGIP+ G++ G F GS + C G+ L G++ C+
Sbjct: 1246 ELSHCEDPGIPQFGYKISDQG-HFAGSTIIYGCNPGYTLHGSSLLKCM 1292
Score = 36.6 bits (83), Expect = 0.027
Identities = 17/44 (38%), Positives = 24/44 (54%)
Query: 200 FPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLALEGG 243
F +G+ +S+ C G++L L C +N WS P C AL GG
Sbjct: 922 FSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCGG 965
Score = 36.2 bits (82), Expect = 0.035
Identities = 19/43 (44%), Positives = 21/43 (48%), Gaps = 2/43 (4%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLC 99
C DPG P G R G F V RF CQ GF+L G +C
Sbjct: 560 CGDPGTPLYGIREGDG--FSNRDVLRFECQFGFELIGEKSIVC 600
Score = 35.0 bits (79), Expect = 0.077
Identities = 19/46 (41%), Positives = 23/46 (50%), Gaps = 2/46 (4%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKH 102
C DPGIP +G R G F GS F C G++L LC K+
Sbjct: 906 CLDPGIPVHGRRY--GHDFSIGSTVSFSCDSGYRLSHEEPLLCEKN 949
Score = 34.3 bits (77), Expect = 0.13
Identities = 18/46 (39%), Positives = 21/46 (45%), Gaps = 4/46 (8%)
Query: 198 TSFPVGTVISYRCFPGFKLDGSAYLECLQNLI----WSSSPPRCLA 239
T F VG I Y C G+ LDG L C+ N + W P C A
Sbjct: 192 TRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRA 237
Score = 32.0 bits (71), Expect = 0.65
Identities = 23/89 (25%), Positives = 37/89 (41%), Gaps = 21/89 (23%)
Query: 150 GFKIRYPDLHNMVSLCRDDGTWNNLPICQGCLRPLASSNGYVNISELQTSFPVGTVISYR 209
GFK+ Y ++ C D GT L + +G+ N V+ +
Sbjct: 547 GFKVNYKEIEK--ESCGDPGT---------PLYGIREGDGFSNRD----------VLRFE 585
Query: 210 CFPGFKLDGSAYLECLQNLIWSSSPPRCL 238
C GF+L G + C +N WS++ P C+
Sbjct: 586 CQFGFELIGEKSIVCQENNQWSANIPICI 614
Score = 31.6 bits (70), Expect = 0.85
Identities = 14/47 (29%), Positives = 22/47 (46%), Gaps = 2/47 (4%)
Query: 54 LQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCL 100
L C +P P +G + G + G V F C G+ L+G + C+
Sbjct: 1945 LDSCPEPQTPSSGIKI--GDRYMVGDVVSFQCDQGYSLQGHSHITCM 1989
Score = 29.6 bits (65), Expect = 3.2
Identities = 19/71 (26%), Positives = 31/71 (43%), Gaps = 8/71 (11%)
Query: 178 QGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQ----NLIWSSS 233
+ C P NG + L + +G+ ++Y C G+ L G + L C+ W+ +
Sbjct: 1595 ESCFDPGNIMNG----TRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRA 1650
Query: 234 PPRCLALEGGR 244
P C A G R
Sbjct: 1651 LPSCHAPCGSR 1661
Score = 29.3 bits (64), Expect = 4.2
Identities = 21/64 (32%), Positives = 28/64 (43%), Gaps = 5/64 (7%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGW---IPSD 113
C DPGIP N R G F GS C++GF T+ + +G + W IP
Sbjct: 730 CPDPGIPINARR--FGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKC 787
Query: 114 NSIC 117
+ C
Sbjct: 788 GAPC 791
Score = 28.9 bits (63), Expect = 5.5
Identities = 18/47 (38%), Positives = 20/47 (42%), Gaps = 2/47 (4%)
Query: 54 LQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCL 100
LQ C DP NGF G F G F C G+ L G + CL
Sbjct: 2117 LQSCPDPRPFRNGFVI--GNDFTVGQTISFECFPGYTLIGNSALTCL 2161
>gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sapiens]
Length = 3667
Score = 73.6 bits (179), Expect = 2e-13
Identities = 60/194 (30%), Positives = 85/194 (43%), Gaps = 18/194 (9%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTL-GWIPSDNS 115
C +PG NG G F SV + C +G+ L G + R C NGT G +P+
Sbjct: 3074 CGNPGTTANGKVFRIDGTTFSSSVI-YSCMEGYILSGPSVRQCTA--NGTWSGTLPN--- 3127
Query: 116 ICVQEDCRIPQIEDAEI-HNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNN- 173
C C P I + + Y G+ + C G+ + + + C +GTW+
Sbjct: 3128 -CTIISCGDPGIPANGLRYGDDYVVGQNVSYMCQPGYTMELNG--SRIRTCTINGTWSGV 3184
Query: 174 LPICQG--CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWS 231
+P C+ C P SNG + T+F G ISY C PG++L A L C+ N WS
Sbjct: 3185 MPTCRAVTCPTPPQISNGRLE----GTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWS 3240
Query: 232 SSPPRCLALEGGRP 245
P+CL G P
Sbjct: 3241 GEVPQCLPKFCGDP 3254
Score = 68.9 bits (167), Expect = 5e-12
Identities = 61/207 (29%), Positives = 85/207 (41%), Gaps = 28/207 (13%)
Query: 52 DDLQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIP 111
D C DPG P +G R S F S R+ C G+ L G+ +R CL + + T G P
Sbjct: 3011 DATGTCGDPGTPGHGSRQESN--FRTKSTVRYACDTGYILHGSEERTCLANGSWT-GRQP 3067
Query: 112 SDNSICVQEDCRIPQIEDAEIHNKTYR-----HGEKLIITCHEGFKIRYPDLHNMVSLCR 166
C C P + K +R +I +C EG+ + P + C
Sbjct: 3068 E----CKAVQCGNP---GTTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQ----CT 3116
Query: 167 DDGTWNN-LPICQ--GCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGF--KLDGSAY 221
+GTW+ LP C C P +NG + VG +SY C PG+ +L+GS
Sbjct: 3117 ANGTWSGTLPNCTIISCGDPGIPANGL----RYGDDYVVGQNVSYMCQPGYTMELNGSRI 3172
Query: 222 LECLQNLIWSSSPPRCLALEGGRPEHL 248
C N WS P C A+ P +
Sbjct: 3173 RTCTINGTWSGVMPTCRAVTCPTPPQI 3199
Score = 65.9 bits (159), Expect = 4e-11
Identities = 55/198 (27%), Positives = 89/198 (44%), Gaps = 17/198 (8%)
Query: 57 CADPGIPENGFR-TPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNS 115
C+ P P +G+ + +GG SV R+ C GF+L G + +C K G W +
Sbjct: 2529 CSTPESPPHGYIISQTGGQL--NSVVRWACDRGFRLVGKSSAVCRKSSYGYHAW-DAPVP 2585
Query: 116 ICVQEDCRIPQI-EDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNN- 173
C C IP+ + I Y G ++ C++G+++ +L ++C+ DGTW+N
Sbjct: 2586 ACQAISCGIPKAPTNGGILTTDYLVGTRVTYFCNDGYRLSSKEL--TTAVCQSDGTWSNH 2643
Query: 174 --LPICQGCLRPLASS----NGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQN 227
P C P +S +G I + + T + + C PG+ G A +ECL N
Sbjct: 2644 NKTPRCVVVTCPSINSFILEHGRWRIVN-GSHYEYKTKVVFSCDPGYHGLGPASIECLPN 2702
Query: 228 LIWS--SSPPRCLALEGG 243
WS + P C + G
Sbjct: 2703 GTWSWRNERPYCQIISCG 2720
Score = 65.1 bits (157), Expect = 7e-11
Identities = 53/198 (26%), Positives = 83/198 (41%), Gaps = 22/198 (11%)
Query: 57 CADPGIPENGFRTPS--GGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDN 114
C+DPGIP N R G F G+V + C G+ L G++ +C + G
Sbjct: 2893 CSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPN-----GQWDKPL 2947
Query: 115 SICVQEDCRIPQIE-DAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWN- 172
C+ DC P + +A + + Y G + +C + L C+ +G W+
Sbjct: 2948 PECIMIDCGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSL----LGQSSRTCQLNGHWSG 3003
Query: 173 NLPICQG-----CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQN 227
+ P C G C P +G S +++F + + Y C G+ L GS CL N
Sbjct: 3004 SQPHCSGDATGTCGDPGTPGHG----SRQESNFRTKSTVRYACDTGYILHGSEERTCLAN 3059
Query: 228 LIWSSSPPRCLALEGGRP 245
W+ P C A++ G P
Sbjct: 3060 GSWTGRQPECKAVQCGNP 3077
Score = 64.7 bits (156), Expect = 9e-11
Identities = 47/170 (27%), Positives = 81/170 (47%), Gaps = 19/170 (11%)
Query: 83 FHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDCRIPQIEDAEIHNKTYRHG-- 140
+ C GF+L G++ R+C + N + G +PS CV C P + I+ +T +G
Sbjct: 2801 YQCNPGFRLIGSSVRICQQDHNWS-GQLPS----CVPVSCGHP---GSPIYGRTSGNGFN 2852
Query: 141 --EKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNLP-ICQ--GCLRPLASSNGYVNISE 195
+ + +C+ G+ ++ P + C+ + W++ P +C+ C P +N
Sbjct: 2853 FNDVVTFSCNIGYLMQGPTK----AQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKI 2908
Query: 196 LQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLALEGGRP 245
+F GTV+ Y C PG+ L GS+ L C N W P C+ ++ G P
Sbjct: 2909 EHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGHP 2958
Score = 64.3 bits (155), Expect = 1e-10
Identities = 42/125 (33%), Positives = 60/125 (48%), Gaps = 12/125 (9%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C +PG+P +G + + G F GSV +FHC+ G L+G+T R CL + G P
Sbjct: 3312 CENPGVPRHGSQNNTFG-FQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWS-GIQPE---- 3365
Query: 117 CVQEDCRIPQIEDAE--IHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTW-NN 173
C+ C+ P+ + HG LI TC GF + H +CR D TW
Sbjct: 3366 CIPHSCKQPETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHR---VCRSDNTWTGK 3422
Query: 174 LPICQ 178
+PIC+
Sbjct: 3423 VPICE 3427
Score = 62.0 bits (149), Expect = 6e-10
Identities = 60/204 (29%), Positives = 82/204 (40%), Gaps = 28/204 (13%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C P P NG + + G+ + C DG++L + +GT W + +
Sbjct: 2592 CGIPKAPTNGGILTTD--YLVGTRVTYFCNDGYRLSSKELTTAVCQSDGT--WSNHNKTP 2647
Query: 117 -CVQEDCRIPQIED--------AEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRD 167
CV C P I ++ Y + K++ +C G Y L C
Sbjct: 2648 RCVVVTC--PSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPG----YHGLGPASIECLP 2701
Query: 168 DGTW---NNLPICQ--GCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYL 222
+GTW N P CQ C NG N QTS+ G+ + C GF L GSA
Sbjct: 2702 NGTWSWRNERPYCQIISCGELPTPPNG--NKIGTQTSY--GSTAIFTCDLGFMLVGSAVR 2757
Query: 223 ECLQNLIWSSSPPRCLALEGGRPE 246
ECL + +WS S RCLA G PE
Sbjct: 2758 ECLSSGLWSESETRCLAGHCGIPE 2781
Score = 57.8 bits (138), Expect = 1e-08
Identities = 59/253 (23%), Positives = 86/253 (33%), Gaps = 73/253 (28%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGF--KLKGATKRLCLKHFNGTL-GWIPSD 113
C DPGIP NG R G + G + CQ G+ +L G+ R C NGT G +P+
Sbjct: 3133 CGDPGIPANGLRY--GDDYVVGQNVSYMCQPGYTMELNGSRIRTCT--INGTWSGVMPTC 3188
Query: 114 NSICVQEDCRIPQIEDAEIHNKTY------------------------------------ 137
++ PQI + + +
Sbjct: 3189 RAVTCPTP---PQISNGRLEGTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQ 3245
Query: 138 ----------------RHGEKLIITCHEGFKIRYPDL--HNMVSLCRDDGTWNNL----- 174
R G+ I F +P + + +C+ DGTW+
Sbjct: 3246 CLPKFCGDPGIPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCI 3305
Query: 175 -PICQGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSS 233
P C P +G N + F VG+V+ + C G L GS CL +L WS
Sbjct: 3306 EPTQTSCENPGVPRHGSQNNT---FGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGI 3362
Query: 234 PPRCLALEGGRPE 246
P C+ +PE
Sbjct: 3363 QPECIPHSCKQPE 3375
Score = 52.8 bits (125), Expect = 4e-07
Identities = 44/167 (26%), Positives = 65/167 (38%), Gaps = 15/167 (8%)
Query: 83 FHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDC-RIPQIEDAEIHNKTYRHGE 141
F C G+ G CL NGT W ++ C C +P + +G
Sbjct: 2683 FSCDPGYHGLGPASIECLP--NGTWSW-RNERPYCQIISCGELPTPPNGNKIGTQTSYGS 2739
Query: 142 KLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNLP---ICQGCLRPLASSNGYVNISELQT 198
I TC GF + + + V C G W+ + C P NG V +
Sbjct: 2740 TAIFTCDLGFML----VGSAVRECLSSGLWSESETRCLAGHCGIPELIVNGQV----IGE 2791
Query: 199 SFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLALEGGRP 245
++ + Y+C PGF+L GS+ C Q+ WS P C+ + G P
Sbjct: 2792 NYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCGHP 2838
Score = 52.4 bits (124), Expect = 5e-07
Identities = 30/80 (37%), Positives = 40/80 (50%), Gaps = 6/80 (7%)
Query: 178 QGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLI--WSSSPP 235
Q C P NG+V + F VG IS+ CFPG+ L G++ L CL + W+ P
Sbjct: 2182 QSCPDPRPFRNGFV----IGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLP 2237
Query: 236 RCLALEGGRPEHLFPVLYFP 255
RC AL GG + +Y P
Sbjct: 2238 RCEALCGGNITAMNGTIYSP 2257
Score = 40.0 bits (92), Expect = 0.002
Identities = 19/48 (39%), Positives = 28/48 (58%), Gaps = 2/48 (4%)
Query: 53 DLQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCL 100
+L+ C DPGIP+ G R G F G F C G++L+G ++ +CL
Sbjct: 1138 NLEPCEDPGIPQYGSRI--GFNFGIGDTLTFSCSSGYRLEGTSEIICL 1183
Score = 38.9 bits (89), Expect = 0.005
Identities = 22/67 (32%), Positives = 30/67 (44%), Gaps = 3/67 (4%)
Query: 56 VCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNS 115
+C DPG PENG R G F GS +F C + + L+GA C + W
Sbjct: 445 LCPDPGEPENGKRI--GSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAW-SDHRP 501
Query: 116 ICVQEDC 122
+C + C
Sbjct: 502 VCKVKTC 508
Score = 38.5 bits (88), Expect = 0.007
Identities = 54/243 (22%), Positives = 86/243 (35%), Gaps = 58/243 (23%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGW---IPSD 113
C DPG NG R G + GS ++C G+ L+G + C+ +G GW +PS
Sbjct: 1661 CFDPGNIMNGTRL--GMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSC 1718
Query: 114 NSICVQEDCRIPQIEDAEIHNKTYRHGEKLI--------ITCHEGFKIRYPDLHNMV--- 162
++ C + + K Y G + F LH++V
Sbjct: 1719 HAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVY 1778
Query: 163 ----------SLCRDDGTWNNLPICQG---CLR-------------------PLASSNGY 190
S + +LP+ G +R P SS
Sbjct: 1779 DGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPRTSSTQC 1838
Query: 191 VNISE------LQTSFPVGTVISYRCFPGFKLDGSAYLEC--LQNLI--WSSSPPRCLAL 240
++ E + F VG+ + + C PG+ L GS + C + N + W+ S P C+
Sbjct: 1839 SSVPEPRFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVP 1898
Query: 241 EGG 243
GG
Sbjct: 1899 CGG 1901
Score = 38.5 bits (88), Expect = 0.007
Identities = 22/78 (28%), Positives = 37/78 (47%), Gaps = 6/78 (7%)
Query: 180 CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLI--WSSSPPRC 237
C P S+G ++ + VG V+S++C G+ L G +++ C+ + W+ P C
Sbjct: 2012 CPEPQTPSSGI----KIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPIC 2067
Query: 238 LALEGGRPEHLFPVLYFP 255
LA GG V+ P
Sbjct: 2068 LAQCGGAMSDFSGVILSP 2085
Score = 38.1 bits (87), Expect = 0.009
Identities = 19/68 (27%), Positives = 37/68 (54%), Gaps = 2/68 (2%)
Query: 194 SELQTSFPVGTVISYRCFPGFKLDGSAYLECL--QNLIWSSSPPRCLALEGGRPEHLFPV 251
S + +F +G +++ C G++L+G++ + CL +WS+ PRC+A G + +
Sbjct: 1152 SRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAECGASATNNEGI 1211
Query: 252 LYFPHIRL 259
L P+ L
Sbjct: 1212 LLSPNYPL 1219
Score = 38.1 bits (87), Expect = 0.009
Identities = 16/44 (36%), Positives = 24/44 (54%), Gaps = 3/44 (6%)
Query: 203 GTVISYRCFPGFKLDGSAYLECLQ---NLIWSSSPPRCLALEGG 243
G + ++C PG++L G + C+Q W SPP C+A GG
Sbjct: 1507 GDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPCGG 1550
Score = 38.1 bits (87), Expect = 0.009
Identities = 18/43 (41%), Positives = 24/43 (55%), Gaps = 2/43 (4%)
Query: 200 FPVGTVISYRCFPGFKLDGSAYLECL--QNLIWSSSPPRCLAL 240
F +G +I Y+C PGF L G+A L C + L +PP C L
Sbjct: 2373 FEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQVL 2415
Score = 37.7 bits (86), Expect = 0.012
Identities = 18/44 (40%), Positives = 25/44 (56%), Gaps = 2/44 (4%)
Query: 203 GTVISYRCFPGFKLDGSAYLECL--QNLIWSSSPPRCLALEGGR 244
G+ I Y C PG+ L GS+ L+C+ + W P C+A GGR
Sbjct: 1334 GSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECGGR 1377
Score = 37.7 bits (86), Expect = 0.012
Identities = 21/62 (33%), Positives = 30/62 (48%), Gaps = 4/62 (6%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C DPG+P NG R G G F C G++L+G + C++ N W PS +
Sbjct: 1488 CRDPGVPMNGTRNGDGRE--PGDTVVFQCDPGYELQGEERITCIQVENRYF-WQPSP-PV 1543
Query: 117 CV 118
C+
Sbjct: 1544 CI 1545
Score = 37.0 bits (84), Expect = 0.020
Identities = 17/48 (35%), Positives = 26/48 (54%), Gaps = 1/48 (2%)
Query: 53 DLQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCL 100
+L C DPGIP+ G++ G F GS + C G+ L G++ C+
Sbjct: 1310 ELSHCEDPGIPQFGYKISDQG-HFAGSTIIYGCNPGYTLHGSSLLKCM 1356
Score = 36.6 bits (83), Expect = 0.027
Identities = 17/44 (38%), Positives = 24/44 (54%)
Query: 200 FPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLALEGG 243
F +G+ +S+ C G++L L C +N WS P C AL GG
Sbjct: 986 FSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCGG 1029
Score = 36.2 bits (82), Expect = 0.035
Identities = 19/43 (44%), Positives = 21/43 (48%), Gaps = 2/43 (4%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLC 99
C DPG P G R G F V RF CQ GF+L G +C
Sbjct: 624 CGDPGTPLYGIREGDG--FSNRDVLRFECQFGFELIGEKSIVC 664
Score = 35.0 bits (79), Expect = 0.077
Identities = 19/46 (41%), Positives = 23/46 (50%), Gaps = 2/46 (4%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKH 102
C DPGIP +G R G F GS F C G++L LC K+
Sbjct: 970 CLDPGIPVHGRRY--GHDFSIGSTVSFSCDSGYRLSHEEPLLCEKN 1013
Score = 34.3 bits (77), Expect = 0.13
Identities = 18/46 (39%), Positives = 21/46 (45%), Gaps = 4/46 (8%)
Query: 198 TSFPVGTVISYRCFPGFKLDGSAYLECLQNLI----WSSSPPRCLA 239
T F VG I Y C G+ LDG L C+ N + W P C A
Sbjct: 152 TRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRA 197
Score = 32.0 bits (71), Expect = 0.65
Identities = 23/89 (25%), Positives = 37/89 (41%), Gaps = 21/89 (23%)
Query: 150 GFKIRYPDLHNMVSLCRDDGTWNNLPICQGCLRPLASSNGYVNISELQTSFPVGTVISYR 209
GFK+ Y ++ C D GT L + +G+ N V+ +
Sbjct: 611 GFKVNYKEIEK--ESCGDPGT---------PLYGIREGDGFSNRD----------VLRFE 649
Query: 210 CFPGFKLDGSAYLECLQNLIWSSSPPRCL 238
C GF+L G + C +N WS++ P C+
Sbjct: 650 CQFGFELIGEKSIVCQENNQWSANIPICI 678
Score = 31.6 bits (70), Expect = 0.85
Identities = 14/47 (29%), Positives = 22/47 (46%), Gaps = 2/47 (4%)
Query: 54 LQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCL 100
L C +P P +G + G + G V F C G+ L+G + C+
Sbjct: 2009 LDSCPEPQTPSSGIKI--GDRYMVGDVVSFQCDQGYSLQGHSHITCM 2053
Score = 29.6 bits (65), Expect = 3.2
Identities = 19/71 (26%), Positives = 31/71 (43%), Gaps = 8/71 (11%)
Query: 178 QGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQ----NLIWSSS 233
+ C P NG + L + +G+ ++Y C G+ L G + L C+ W+ +
Sbjct: 1659 ESCFDPGNIMNG----TRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRA 1714
Query: 234 PPRCLALEGGR 244
P C A G R
Sbjct: 1715 LPSCHAPCGSR 1725
Score = 29.3 bits (64), Expect = 4.2
Identities = 21/64 (32%), Positives = 28/64 (43%), Gaps = 5/64 (7%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGW---IPSD 113
C DPGIP N R G F GS C++GF T+ + +G + W IP
Sbjct: 794 CPDPGIPINARR--FGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKC 851
Query: 114 NSIC 117
+ C
Sbjct: 852 GAPC 855
Score = 28.9 bits (63), Expect = 5.5
Identities = 18/47 (38%), Positives = 20/47 (42%), Gaps = 2/47 (4%)
Query: 54 LQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCL 100
LQ C DP NGF G F G F C G+ L G + CL
Sbjct: 2181 LQSCPDPRPFRNGFVI--GNDFTVGQTISFECFPGYTLIGNSALTCL 2225
>gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sapiens]
Length = 3707
Score = 73.6 bits (179), Expect = 2e-13
Identities = 60/194 (30%), Positives = 85/194 (43%), Gaps = 18/194 (9%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTL-GWIPSDNS 115
C +PG NG G F SV + C +G+ L G + R C NGT G +P+
Sbjct: 3114 CGNPGTTANGKVFRIDGTTFSSSVI-YSCMEGYILSGPSVRQCTA--NGTWSGTLPN--- 3167
Query: 116 ICVQEDCRIPQIEDAEI-HNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNN- 173
C C P I + + Y G+ + C G+ + + + C +GTW+
Sbjct: 3168 -CTIISCGDPGIPANGLRYGDDYVVGQNVSYMCQPGYTMELNG--SRIRTCTINGTWSGV 3224
Query: 174 LPICQG--CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWS 231
+P C+ C P SNG + T+F G ISY C PG++L A L C+ N WS
Sbjct: 3225 MPTCRAVTCPTPPQISNGRLE----GTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWS 3280
Query: 232 SSPPRCLALEGGRP 245
P+CL G P
Sbjct: 3281 GEVPQCLPKFCGDP 3294
Score = 68.9 bits (167), Expect = 5e-12
Identities = 61/207 (29%), Positives = 85/207 (41%), Gaps = 28/207 (13%)
Query: 52 DDLQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIP 111
D C DPG P +G R S F S R+ C G+ L G+ +R CL + + T G P
Sbjct: 3051 DATGTCGDPGTPGHGSRQESN--FRTKSTVRYACDTGYILHGSEERTCLANGSWT-GRQP 3107
Query: 112 SDNSICVQEDCRIPQIEDAEIHNKTYR-----HGEKLIITCHEGFKIRYPDLHNMVSLCR 166
C C P + K +R +I +C EG+ + P + C
Sbjct: 3108 E----CKAVQCGNP---GTTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQ----CT 3156
Query: 167 DDGTWNN-LPICQ--GCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGF--KLDGSAY 221
+GTW+ LP C C P +NG + VG +SY C PG+ +L+GS
Sbjct: 3157 ANGTWSGTLPNCTIISCGDPGIPANGL----RYGDDYVVGQNVSYMCQPGYTMELNGSRI 3212
Query: 222 LECLQNLIWSSSPPRCLALEGGRPEHL 248
C N WS P C A+ P +
Sbjct: 3213 RTCTINGTWSGVMPTCRAVTCPTPPQI 3239
Score = 65.9 bits (159), Expect = 4e-11
Identities = 55/198 (27%), Positives = 89/198 (44%), Gaps = 17/198 (8%)
Query: 57 CADPGIPENGFR-TPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNS 115
C+ P P +G+ + +GG SV R+ C GF+L G + +C K G W +
Sbjct: 2569 CSTPESPPHGYIISQTGGQL--NSVVRWACDRGFRLVGKSSAVCRKSSYGYHAW-DAPVP 2625
Query: 116 ICVQEDCRIPQI-EDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNN- 173
C C IP+ + I Y G ++ C++G+++ +L ++C+ DGTW+N
Sbjct: 2626 ACQAISCGIPKAPTNGGILTTDYLVGTRVTYFCNDGYRLSSKEL--TTAVCQSDGTWSNH 2683
Query: 174 --LPICQGCLRPLASS----NGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQN 227
P C P +S +G I + + T + + C PG+ G A +ECL N
Sbjct: 2684 NKTPRCVVVTCPSINSFILEHGRWRIVN-GSHYEYKTKVVFSCDPGYHGLGPASIECLPN 2742
Query: 228 LIWS--SSPPRCLALEGG 243
WS + P C + G
Sbjct: 2743 GTWSWRNERPYCQIISCG 2760
Score = 65.1 bits (157), Expect = 7e-11
Identities = 53/198 (26%), Positives = 83/198 (41%), Gaps = 22/198 (11%)
Query: 57 CADPGIPENGFRTPS--GGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDN 114
C+DPGIP N R G F G+V + C G+ L G++ +C + G
Sbjct: 2933 CSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPN-----GQWDKPL 2987
Query: 115 SICVQEDCRIPQIE-DAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWN- 172
C+ DC P + +A + + Y G + +C + L C+ +G W+
Sbjct: 2988 PECIMIDCGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSL----LGQSSRTCQLNGHWSG 3043
Query: 173 NLPICQG-----CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQN 227
+ P C G C P +G S +++F + + Y C G+ L GS CL N
Sbjct: 3044 SQPHCSGDATGTCGDPGTPGHG----SRQESNFRTKSTVRYACDTGYILHGSEERTCLAN 3099
Query: 228 LIWSSSPPRCLALEGGRP 245
W+ P C A++ G P
Sbjct: 3100 GSWTGRQPECKAVQCGNP 3117
Score = 64.7 bits (156), Expect = 9e-11
Identities = 47/170 (27%), Positives = 81/170 (47%), Gaps = 19/170 (11%)
Query: 83 FHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDCRIPQIEDAEIHNKTYRHG-- 140
+ C GF+L G++ R+C + N + G +PS CV C P + I+ +T +G
Sbjct: 2841 YQCNPGFRLIGSSVRICQQDHNWS-GQLPS----CVPVSCGHP---GSPIYGRTSGNGFN 2892
Query: 141 --EKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNLP-ICQ--GCLRPLASSNGYVNISE 195
+ + +C+ G+ ++ P + C+ + W++ P +C+ C P +N
Sbjct: 2893 FNDVVTFSCNIGYLMQGPTK----AQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKI 2948
Query: 196 LQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLALEGGRP 245
+F GTV+ Y C PG+ L GS+ L C N W P C+ ++ G P
Sbjct: 2949 EHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGHP 2998
Score = 64.3 bits (155), Expect = 1e-10
Identities = 42/125 (33%), Positives = 60/125 (48%), Gaps = 12/125 (9%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C +PG+P +G + + G F GSV +FHC+ G L+G+T R CL + G P
Sbjct: 3352 CENPGVPRHGSQNNTFG-FQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWS-GIQPE---- 3405
Query: 117 CVQEDCRIPQIEDAE--IHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTW-NN 173
C+ C+ P+ + HG LI TC GF + H +CR D TW
Sbjct: 3406 CIPHSCKQPETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHR---VCRSDNTWTGK 3462
Query: 174 LPICQ 178
+PIC+
Sbjct: 3463 VPICE 3467
Score = 62.0 bits (149), Expect = 6e-10
Identities = 60/204 (29%), Positives = 82/204 (40%), Gaps = 28/204 (13%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C P P NG + + G+ + C DG++L + +GT W + +
Sbjct: 2632 CGIPKAPTNGGILTTD--YLVGTRVTYFCNDGYRLSSKELTTAVCQSDGT--WSNHNKTP 2687
Query: 117 -CVQEDCRIPQIED--------AEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRD 167
CV C P I ++ Y + K++ +C G Y L C
Sbjct: 2688 RCVVVTC--PSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPG----YHGLGPASIECLP 2741
Query: 168 DGTW---NNLPICQ--GCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYL 222
+GTW N P CQ C NG N QTS+ G+ + C GF L GSA
Sbjct: 2742 NGTWSWRNERPYCQIISCGELPTPPNG--NKIGTQTSY--GSTAIFTCDLGFMLVGSAVR 2797
Query: 223 ECLQNLIWSSSPPRCLALEGGRPE 246
ECL + +WS S RCLA G PE
Sbjct: 2798 ECLSSGLWSESETRCLAGHCGIPE 2821
Score = 57.8 bits (138), Expect = 1e-08
Identities = 59/253 (23%), Positives = 86/253 (33%), Gaps = 73/253 (28%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGF--KLKGATKRLCLKHFNGTL-GWIPSD 113
C DPGIP NG R G + G + CQ G+ +L G+ R C NGT G +P+
Sbjct: 3173 CGDPGIPANGLRY--GDDYVVGQNVSYMCQPGYTMELNGSRIRTCT--INGTWSGVMPTC 3228
Query: 114 NSICVQEDCRIPQIEDAEIHNKTY------------------------------------ 137
++ PQI + + +
Sbjct: 3229 RAVTCPTP---PQISNGRLEGTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQ 3285
Query: 138 ----------------RHGEKLIITCHEGFKIRYPDL--HNMVSLCRDDGTWNNL----- 174
R G+ I F +P + + +C+ DGTW+
Sbjct: 3286 CLPKFCGDPGIPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCI 3345
Query: 175 -PICQGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSS 233
P C P +G N + F VG+V+ + C G L GS CL +L WS
Sbjct: 3346 EPTQTSCENPGVPRHGSQNNT---FGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGI 3402
Query: 234 PPRCLALEGGRPE 246
P C+ +PE
Sbjct: 3403 QPECIPHSCKQPE 3415
Score = 52.8 bits (125), Expect = 4e-07
Identities = 44/167 (26%), Positives = 65/167 (38%), Gaps = 15/167 (8%)
Query: 83 FHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDC-RIPQIEDAEIHNKTYRHGE 141
F C G+ G CL NGT W ++ C C +P + +G
Sbjct: 2723 FSCDPGYHGLGPASIECLP--NGTWSW-RNERPYCQIISCGELPTPPNGNKIGTQTSYGS 2779
Query: 142 KLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNLP---ICQGCLRPLASSNGYVNISELQT 198
I TC GF + + + V C G W+ + C P NG V +
Sbjct: 2780 TAIFTCDLGFML----VGSAVRECLSSGLWSESETRCLAGHCGIPELIVNGQV----IGE 2831
Query: 199 SFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLALEGGRP 245
++ + Y+C PGF+L GS+ C Q+ WS P C+ + G P
Sbjct: 2832 NYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCGHP 2878
Score = 52.4 bits (124), Expect = 5e-07
Identities = 30/80 (37%), Positives = 40/80 (50%), Gaps = 6/80 (7%)
Query: 178 QGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLI--WSSSPP 235
Q C P NG+V + F VG IS+ CFPG+ L G++ L CL + W+ P
Sbjct: 2222 QSCPDPRPFRNGFV----IGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLP 2277
Query: 236 RCLALEGGRPEHLFPVLYFP 255
RC AL GG + +Y P
Sbjct: 2278 RCEALCGGNITAMNGTIYSP 2297
Score = 40.0 bits (92), Expect = 0.002
Identities = 19/48 (39%), Positives = 28/48 (58%), Gaps = 2/48 (4%)
Query: 53 DLQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCL 100
+L+ C DPGIP+ G R G F G F C G++L+G ++ +CL
Sbjct: 1178 NLEPCEDPGIPQYGSRI--GFNFGIGDTLTFSCSSGYRLEGTSEIICL 1223
Score = 38.9 bits (89), Expect = 0.005
Identities = 22/67 (32%), Positives = 30/67 (44%), Gaps = 3/67 (4%)
Query: 56 VCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNS 115
+C DPG PENG R G F GS +F C + + L+GA C + W
Sbjct: 485 LCPDPGEPENGKRI--GSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAW-SDHRP 541
Query: 116 ICVQEDC 122
+C + C
Sbjct: 542 VCKVKTC 548
Score = 38.5 bits (88), Expect = 0.007
Identities = 54/243 (22%), Positives = 86/243 (35%), Gaps = 58/243 (23%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGW---IPSD 113
C DPG NG R G + GS ++C G+ L+G + C+ +G GW +PS
Sbjct: 1701 CFDPGNIMNGTRL--GMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSC 1758
Query: 114 NSICVQEDCRIPQIEDAEIHNKTYRHGEKLI--------ITCHEGFKIRYPDLHNMV--- 162
++ C + + K Y G + F LH++V
Sbjct: 1759 HAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVY 1818
Query: 163 ----------SLCRDDGTWNNLPICQG---CLR-------------------PLASSNGY 190
S + +LP+ G +R P SS
Sbjct: 1819 DGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPRTSSTQC 1878
Query: 191 VNISE------LQTSFPVGTVISYRCFPGFKLDGSAYLEC--LQNLI--WSSSPPRCLAL 240
++ E + F VG+ + + C PG+ L GS + C + N + W+ S P C+
Sbjct: 1879 SSVPEPRFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVP 1938
Query: 241 EGG 243
GG
Sbjct: 1939 CGG 1941
Score = 38.5 bits (88), Expect = 0.007
Identities = 22/78 (28%), Positives = 37/78 (47%), Gaps = 6/78 (7%)
Query: 180 CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLI--WSSSPPRC 237
C P S+G ++ + VG V+S++C G+ L G +++ C+ + W+ P C
Sbjct: 2052 CPEPQTPSSGI----KIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPIC 2107
Query: 238 LALEGGRPEHLFPVLYFP 255
LA GG V+ P
Sbjct: 2108 LAQCGGAMSDFSGVILSP 2125
Score = 38.1 bits (87), Expect = 0.009
Identities = 19/68 (27%), Positives = 37/68 (54%), Gaps = 2/68 (2%)
Query: 194 SELQTSFPVGTVISYRCFPGFKLDGSAYLECL--QNLIWSSSPPRCLALEGGRPEHLFPV 251
S + +F +G +++ C G++L+G++ + CL +WS+ PRC+A G + +
Sbjct: 1192 SRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAECGASATNNEGI 1251
Query: 252 LYFPHIRL 259
L P+ L
Sbjct: 1252 LLSPNYPL 1259
Score = 38.1 bits (87), Expect = 0.009
Identities = 16/44 (36%), Positives = 24/44 (54%), Gaps = 3/44 (6%)
Query: 203 GTVISYRCFPGFKLDGSAYLECLQ---NLIWSSSPPRCLALEGG 243
G + ++C PG++L G + C+Q W SPP C+A GG
Sbjct: 1547 GDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPCGG 1590
Score = 38.1 bits (87), Expect = 0.009
Identities = 18/43 (41%), Positives = 24/43 (55%), Gaps = 2/43 (4%)
Query: 200 FPVGTVISYRCFPGFKLDGSAYLECL--QNLIWSSSPPRCLAL 240
F +G +I Y+C PGF L G+A L C + L +PP C L
Sbjct: 2413 FEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQVL 2455
Score = 37.7 bits (86), Expect = 0.012
Identities = 18/44 (40%), Positives = 25/44 (56%), Gaps = 2/44 (4%)
Query: 203 GTVISYRCFPGFKLDGSAYLECL--QNLIWSSSPPRCLALEGGR 244
G+ I Y C PG+ L GS+ L+C+ + W P C+A GGR
Sbjct: 1374 GSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECGGR 1417
Score = 37.7 bits (86), Expect = 0.012
Identities = 21/62 (33%), Positives = 30/62 (48%), Gaps = 4/62 (6%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C DPG+P NG R G G F C G++L+G + C++ N W PS +
Sbjct: 1528 CRDPGVPMNGTRNGDGRE--PGDTVVFQCDPGYELQGEERITCIQVENRYF-WQPSP-PV 1583
Query: 117 CV 118
C+
Sbjct: 1584 CI 1585
Score = 37.0 bits (84), Expect = 0.020
Identities = 17/48 (35%), Positives = 26/48 (54%), Gaps = 1/48 (2%)
Query: 53 DLQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCL 100
+L C DPGIP+ G++ G F GS + C G+ L G++ C+
Sbjct: 1350 ELSHCEDPGIPQFGYKISDQG-HFAGSTIIYGCNPGYTLHGSSLLKCM 1396
Score = 36.6 bits (83), Expect = 0.027
Identities = 17/44 (38%), Positives = 24/44 (54%)
Query: 200 FPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLALEGG 243
F +G+ +S+ C G++L L C +N WS P C AL GG
Sbjct: 1026 FSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCGG 1069
Score = 36.2 bits (82), Expect = 0.035
Identities = 19/43 (44%), Positives = 21/43 (48%), Gaps = 2/43 (4%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLC 99
C DPG P G R G F V RF CQ GF+L G +C
Sbjct: 664 CGDPGTPLYGIREGDG--FSNRDVLRFECQFGFELIGEKSIVC 704
Score = 35.0 bits (79), Expect = 0.077
Identities = 19/46 (41%), Positives = 23/46 (50%), Gaps = 2/46 (4%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKH 102
C DPGIP +G R G F GS F C G++L LC K+
Sbjct: 1010 CLDPGIPVHGRRY--GHDFSIGSTVSFSCDSGYRLSHEEPLLCEKN 1053
Score = 34.3 bits (77), Expect = 0.13
Identities = 18/46 (39%), Positives = 21/46 (45%), Gaps = 4/46 (8%)
Query: 198 TSFPVGTVISYRCFPGFKLDGSAYLECLQNLI----WSSSPPRCLA 239
T F VG I Y C G+ LDG L C+ N + W P C A
Sbjct: 192 TRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRA 237
Score = 32.0 bits (71), Expect = 0.65
Identities = 23/89 (25%), Positives = 37/89 (41%), Gaps = 21/89 (23%)
Query: 150 GFKIRYPDLHNMVSLCRDDGTWNNLPICQGCLRPLASSNGYVNISELQTSFPVGTVISYR 209
GFK+ Y ++ C D GT L + +G+ N V+ +
Sbjct: 651 GFKVNYKEIEK--ESCGDPGT---------PLYGIREGDGFSNRD----------VLRFE 689
Query: 210 CFPGFKLDGSAYLECLQNLIWSSSPPRCL 238
C GF+L G + C +N WS++ P C+
Sbjct: 690 CQFGFELIGEKSIVCQENNQWSANIPICI 718
Score = 31.6 bits (70), Expect = 0.85
Identities = 14/47 (29%), Positives = 22/47 (46%), Gaps = 2/47 (4%)
Query: 54 LQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCL 100
L C +P P +G + G + G V F C G+ L+G + C+
Sbjct: 2049 LDSCPEPQTPSSGIKI--GDRYMVGDVVSFQCDQGYSLQGHSHITCM 2093
Score = 29.6 bits (65), Expect = 3.2
Identities = 19/71 (26%), Positives = 31/71 (43%), Gaps = 8/71 (11%)
Query: 178 QGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQ----NLIWSSS 233
+ C P NG + L + +G+ ++Y C G+ L G + L C+ W+ +
Sbjct: 1699 ESCFDPGNIMNG----TRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRA 1754
Query: 234 PPRCLALEGGR 244
P C A G R
Sbjct: 1755 LPSCHAPCGSR 1765
Score = 29.3 bits (64), Expect = 4.2
Identities = 21/64 (32%), Positives = 28/64 (43%), Gaps = 5/64 (7%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGW---IPSD 113
C DPGIP N R G F GS C++GF T+ + +G + W IP
Sbjct: 834 CPDPGIPINARR--FGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKC 891
Query: 114 NSIC 117
+ C
Sbjct: 892 GAPC 895
Score = 28.9 bits (63), Expect = 5.5
Identities = 18/47 (38%), Positives = 20/47 (42%), Gaps = 2/47 (4%)
Query: 54 LQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCL 100
LQ C DP NGF G F G F C G+ L G + CL
Sbjct: 2221 LQSCPDPRPFRNGFVI--GNDFTVGQTISFECFPGYTLIGNSALTCL 2265
>gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens]
Length = 3565
Score = 70.5 bits (171), Expect = 2e-12
Identities = 58/197 (29%), Positives = 84/197 (42%), Gaps = 22/197 (11%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C P NG SG F + C GF+L G + R+CL+ + +
Sbjct: 2681 CGSPDPIVNGHI--SGDGFSYRDTVVYQCNPGFRLVGTSVRICLQDHKWS-----GQTPV 2733
Query: 117 CVQEDCRIPQIEDAEIHNKT-YRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNN-L 174
CV C P N + + + + TC+ G+ ++ + CR +G W++ L
Sbjct: 2734 CVPITCGHPGNPAHGFTNGSEFNLNDVVNFTCNTGYLLQGVSR----AQCRSNGQWSSPL 2789
Query: 175 PICQ--GCLRP----LASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNL 228
P C+ C P A +G N E SF G I Y C GF L GS+ L C+ N
Sbjct: 2790 PTCRVVNCSDPGFVENAIRHGQQNFPE---SFEYGMSILYHCKKGFYLLGSSALTCMANG 2846
Query: 229 IWSSSPPRCLALEGGRP 245
+W S P+CLA+ G P
Sbjct: 2847 LWDRSLPKCLAISCGHP 2863
Score = 68.6 bits (166), Expect = 6e-12
Identities = 55/191 (28%), Positives = 82/191 (42%), Gaps = 22/191 (11%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C DPG P +G R G F S+ RF C+ G +L+G+ +R CL NG+ + +
Sbjct: 2921 CGDPGTPAHGSRL--GDDFKTKSLLRFSCEMGHQLRGSPERTCL--LNGSWSGL---QPV 2973
Query: 117 CVQEDCRIP--QIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNL 174
C C P + + +I C EG+K M C +GTW
Sbjct: 2974 CEAVSCGNPGTPTNGMIVSSDGILFSSSVIYACWEGYKTS----GLMTRHCTANGTWTGT 3029
Query: 175 -PICQ--GCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDG--SAYLECLQNLI 229
P C C P +NG + T F +SY+C PG+ ++ SA + C ++
Sbjct: 3030 APDCTIISCGDPGTLANGI----QFGTDFTFNKTVSYQCNPGYVMEAVTSATIRCTKDGR 3085
Query: 230 WSSSPPRCLAL 240
W+ S P C A+
Sbjct: 3086 WNPSKPVCKAV 3096
Score = 64.3 bits (155), Expect = 1e-10
Identities = 65/246 (26%), Positives = 104/246 (42%), Gaps = 30/246 (12%)
Query: 57 CADPGIPENGFRTPSGGV---FFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSD 113
C+DPG EN R F G +HC+ GF L G++ C+ NG W D
Sbjct: 2797 CSDPGFVENAIRHGQQNFPESFEYGMSILYHCKKGFYLLGSSALTCMA--NGL--W---D 2849
Query: 114 NSI--CVQEDCRIPQIE-DAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGT 170
S+ C+ C P + +A + + + +G + +C + + N +C++D
Sbjct: 2850 RSLPKCLAISCGHPGVPANAVLTGELFTYGAVVHYSCRGSESL----IGNDTRVCQEDSH 2905
Query: 171 WNN-LPICQG-----CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLEC 224
W+ LP C G C P ++G S L F +++ + C G +L GS C
Sbjct: 2906 WSGALPHCTGNNPGFCGDPGTPAHG----SRLGDDFKTKSLLRFSCEMGHQLRGSPERTC 2961
Query: 225 LQNLIWSSSPPRCLALEGGRP--EHLFPVLYFPHIRLAAAVLYFC-PVLKSSPTPAPTCS 281
L N WS P C A+ G P ++ I +++V+Y C K+S C+
Sbjct: 2962 LLNGSWSGLQPVCEAVSCGNPGTPTNGMIVSSDGILFSSSVIYACWEGYKTSGLMTRHCT 3021
Query: 282 STSTTT 287
+ T T
Sbjct: 3022 ANGTWT 3027
Score = 62.0 bits (149), Expect = 6e-10
Identities = 48/195 (24%), Positives = 79/195 (40%), Gaps = 15/195 (7%)
Query: 56 VCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNS 115
+C P +NG T G F GS + C DG++L + C G W +
Sbjct: 3097 LCPQPPPVQNG--TVEGSDFRWGSSISYSCMDGYQLSHSAILSC----EGRGVW-KGEIP 3149
Query: 116 ICVQEDCRIPQIE-DAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNL 174
C+ C P I + + K++ + ++ C F + + + +C+ DGTW+ +
Sbjct: 3150 QCLPVFCGDPGIPAEGRLSGKSFTYKSEVFFQCKSPFIL----VGSSRRVCQADGTWSGI 3205
Query: 175 -PICQGCLRPLASSNG--YVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWS 231
P C G + I + VG+ + +RC G+ + GS CL NL WS
Sbjct: 3206 QPTCIDPAHNTCPDPGTPHFGIQNSSRGYEVGSTVFFRCRKGYHIQGSTTRTCLANLTWS 3265
Query: 232 SSPPRCLALEGGRPE 246
C+ +PE
Sbjct: 3266 GIQTECIPHACRQPE 3280
Score = 61.6 bits (148), Expect = 8e-10
Identities = 44/179 (24%), Positives = 74/179 (41%), Gaps = 20/179 (11%)
Query: 78 GSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDCRIPQIE-DAEIHNKT 136
GS + C+ G+++ G + C ++ G W S +C C IP+ +
Sbjct: 2453 GSKVHYFCKPGYRMVGHSNATCRRNPLGMYQW-DSLTPLCQAVSCGIPESPGNGSFTGNE 2511
Query: 137 YRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNL---PICQGCLRPLASSNGYVNI 193
+ K++ CHEGFK+ ++C++DG W+N P C +P+A + +
Sbjct: 2512 FTLDSKVVYECHEGFKLE--SSQQATAVCQEDGLWSNKGKPPTC----KPVACPSIEAQL 2565
Query: 194 SE-------LQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWS--SSPPRCLALEGG 243
SE + G + C PG+ L+G L C N W+ P C + G
Sbjct: 2566 SEHVIWRLVSGSLNEYGAQVLLSCSPGYYLEGWRLLRCQANGTWNIGDERPSCRVISCG 2624
Score = 61.2 bits (147), Expect = 1e-09
Identities = 52/187 (27%), Positives = 76/187 (40%), Gaps = 17/187 (9%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C DPGIP G SG F S F C+ F L G+++R+C +GT I
Sbjct: 3156 CGDPGIPAEG--RLSGKSFTYKSEVFFQCKSPFILVGSSRRVC--QADGTWSGIQPTCID 3211
Query: 117 CVQEDCRIPQIEDAEIHNKT--YRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNL 174
C P I N + Y G + C +G+ I+ + C + TW+ +
Sbjct: 3212 PAHNTCPDPGTPHFGIQNSSRGYEVGSTVFFRCRKGYHIQ----GSTTRTCLANLTWSGI 3267
Query: 175 P---ICQGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKL-DGSAYLECLQNLIW 230
I C +P ++ V +L T G + Y C PGF L GS + C ++ W
Sbjct: 3268 QTECIPHACRQPETPAHADVRAIDLPT---FGYTLVYTCHPGFFLAGGSEHRTCKADMKW 3324
Query: 231 SSSPPRC 237
+ P C
Sbjct: 3325 TGKSPVC 3331
Score = 57.8 bits (138), Expect = 1e-08
Identities = 49/195 (25%), Positives = 80/195 (41%), Gaps = 19/195 (9%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLK--HFNGTLGWIPSDN 114
C PG+P N T G +F G+V + C+ L G R+C + H++G L +N
Sbjct: 2860 CGHPGVPANAVLT--GELFTYGAVVHYSCRGSESLIGNDTRVCQEDSHWSGALPHCTGNN 2917
Query: 115 -SICVQEDCRIPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNN 173
C D P ++ L +C G ++R + C +G+W+
Sbjct: 2918 PGFC--GDPGTPA--HGSRLGDDFKTKSLLRFSCEMGHQLR----GSPERTCLLNGSWSG 2969
Query: 174 L-PICQG--CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIW 230
L P+C+ C P +NG + S+ + + Y C+ G+K G C N W
Sbjct: 2970 LQPVCEAVSCGNPGTPTNGMIVSSD---GILFSSSVIYACWEGYKTSGLMTRHCTANGTW 3026
Query: 231 SSSPPRCLALEGGRP 245
+ + P C + G P
Sbjct: 3027 TGTAPDCTIISCGDP 3041
Score = 41.6 bits (96), Expect = 8e-04
Identities = 31/124 (25%), Positives = 50/124 (40%), Gaps = 23/124 (18%)
Query: 134 NKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNLPICQGCLRPLASSNGYVNI 193
N+ Y H + I GF + Y + L CQ P SN
Sbjct: 1887 NQLYLHFQSDISVAAAGFHLEYKTV--------------GLAACQ---EPALPSNSI--- 1926
Query: 194 SELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLI--WSSSPPRCLALEGGRPEHLFPV 251
++ + V V+S++C PG+ L G +++ C+ + W+ P C+A GG L V
Sbjct: 1927 -KIGDRYMVNDVLSFQCEPGYTLQGRSHISCMPGTVRRWNYPSPLCIATCGGTLSTLGGV 1985
Query: 252 LYFP 255
+ P
Sbjct: 1986 ILSP 1989
Score = 41.2 bits (95), Expect = 0.001
Identities = 16/44 (36%), Positives = 25/44 (56%), Gaps = 3/44 (6%)
Query: 203 GTVISYRCFPGFKLDGSAYLECLQ---NLIWSSSPPRCLALEGG 243
G ++++C PG++L G A + C+Q W PP C+A GG
Sbjct: 1411 GDTVTFQCDPGYQLQGQAKITCVQLNNRFFWQPDPPTCIAACGG 1454
Score = 40.8 bits (94), Expect = 0.001
Identities = 24/54 (44%), Positives = 29/54 (53%), Gaps = 4/54 (7%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGF-KLKGATKRLCLKHFNGTLGW 109
C DPGIP NG R G F GS FHC DGF K +G+ C+ +G + W
Sbjct: 698 CHDPGIPINGRRF--GDRFLLGSSVSFHCDDGFVKTQGSESITCILQ-DGNVVW 748
Score = 39.3 bits (90), Expect = 0.004
Identities = 17/42 (40%), Positives = 27/42 (64%), Gaps = 2/42 (4%)
Query: 200 FPVGTVISYRCFPGFKLDGSAYLECL--QNLIWSSSPPRCLA 239
F VG +++ CF G++L+G+ L CL +WS+ PRC+A
Sbjct: 1062 FGVGDSLTFSCFLGYRLEGATKLTCLGGGRRVWSAPLPRCVA 1103
Score = 39.3 bits (90), Expect = 0.004
Identities = 21/55 (38%), Positives = 27/55 (49%), Gaps = 1/55 (1%)
Query: 46 QLTGGFDDLQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCL 100
QLT DL C DPGIP G+R G F +V + C G+ + G+ CL
Sbjct: 1207 QLTYTSFDLVKCEDPGIPNYGYRIRDEG-HFTDTVVLYSCNPGYAMHGSNTLTCL 1260
Score = 39.3 bits (90), Expect = 0.004
Identities = 22/62 (35%), Positives = 30/62 (48%), Gaps = 4/62 (6%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C DPG+P+NG T G G F C G++L+G K C++ N W P D
Sbjct: 1392 CNDPGMPQNG--TRYGDSREAGDTVTFQCDPGYQLQGQAKITCVQ-LNNRFFWQP-DPPT 1447
Query: 117 CV 118
C+
Sbjct: 1448 CI 1449
Score = 39.3 bits (90), Expect = 0.004
Identities = 21/62 (33%), Positives = 30/62 (48%), Gaps = 6/62 (9%)
Query: 178 QGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQ--NLIWSSSPP 235
Q C P NGY+ + + + VG +S+ C+PG+ L G L C N W+ P
Sbjct: 2086 QNCPDPPPFQNGYM----INSDYSVGQSVSFECYPGYILIGHPVLTCQHGINRNWNYPFP 2141
Query: 236 RC 237
RC
Sbjct: 2142 RC 2143
Score = 38.9 bits (89), Expect = 0.005
Identities = 23/68 (33%), Positives = 32/68 (47%), Gaps = 4/68 (5%)
Query: 56 VCADPGIPENGFRTPSGGVFFE-GSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDN 114
+C DPGIPENG R +G F G+ +F C+D + L+G+ C + W
Sbjct: 348 MCPDPGIPENGRR--AGSDFSRVGANVQFSCEDNYVLQGSKSITCQRVTETLAAW-SDHR 404
Query: 115 SICVQEDC 122
IC C
Sbjct: 405 PICRARTC 412
Score = 38.9 bits (89), Expect = 0.005
Identities = 21/48 (43%), Positives = 26/48 (54%), Gaps = 2/48 (4%)
Query: 53 DLQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCL 100
DL+ C DPG+P F G F G F C G++L+GATK CL
Sbjct: 1042 DLEPCDDPGVP--AFSRRIGFHFGVGDSLTFSCFLGYRLEGATKLTCL 1087
Score = 38.1 bits (87), Expect = 0.009
Identities = 31/105 (29%), Positives = 45/105 (42%), Gaps = 27/105 (25%)
Query: 146 TCHEGFKIRYPDLHNMVSLCRDDGTWNNLPICQGCLRPLASSNGYVNISELQTSFPVGTV 205
T +GFKIRY P C PL + G +N +T+ VG+
Sbjct: 2419 TSKKGFKIRYA-----------------APYCS-LTHPL-KNGGILN----RTAGAVGSK 2455
Query: 206 ISYRCFPGFKLDGSAYLECLQNLI----WSSSPPRCLALEGGRPE 246
+ Y C PG+++ G + C +N + W S P C A+ G PE
Sbjct: 2456 VHYFCKPGYRMVGHSNATCRRNPLGMYQWDSLTPLCQAVSCGIPE 2500
Score = 37.7 bits (86), Expect = 0.012
Identities = 20/48 (41%), Positives = 29/48 (60%), Gaps = 4/48 (8%)
Query: 200 FPVGTVISYRCFPGF-KLDGSAYLECLQ---NLIWSSSPPRCLALEGG 243
F +G+ +S+ C GF K GS + C+ N++WSS+ PRC A GG
Sbjct: 714 FLLGSSVSFHCDDGFVKTQGSESITCILQDGNVVWSSTVPRCEAPCGG 761
Score = 36.2 bits (82), Expect = 0.035
Identities = 20/64 (31%), Positives = 32/64 (50%), Gaps = 4/64 (6%)
Query: 180 CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLA 239
CL P NG+ + + F + + +++ C PG+ L L C +N W+ + P C A
Sbjct: 874 CLDPGIPVNGHRHGGD----FGIRSTVTFSCDPGYTLSDDEPLVCERNHQWNHALPSCDA 929
Query: 240 LEGG 243
L GG
Sbjct: 930 LCGG 933
Score = 36.2 bits (82), Expect = 0.035
Identities = 17/43 (39%), Positives = 23/43 (53%), Gaps = 2/43 (4%)
Query: 204 TVISYRCFPGFKLDGSAYLECL--QNLIWSSSPPRCLALEGGR 244
TV+ Y C PG+ + GS L CL +W P C+A GG+
Sbjct: 1239 TVVLYSCNPGYAMHGSNTLTCLSGDRRVWDKPLPSCIAECGGQ 1281
Score = 35.8 bits (81), Expect = 0.045
Identities = 21/61 (34%), Positives = 29/61 (47%), Gaps = 3/61 (4%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C DPGIP NG R GG F S F C G+ L +C ++ +PS +++
Sbjct: 874 CLDPGIPVNGHR--HGGDFGIRSTVTFSCDPGYTLSDDEPLVCERNHQWNHA-LPSCDAL 930
Query: 117 C 117
C
Sbjct: 931 C 931
Score = 34.7 bits (78), Expect = 0.10
Identities = 18/43 (41%), Positives = 19/43 (44%), Gaps = 2/43 (4%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLC 99
C DPGIP G RT G F G F C F+L G C
Sbjct: 528 CGDPGIPAYGKRT--GSSFLHGDTLTFECPAAFELVGERVITC 568
Score = 34.7 bits (78), Expect = 0.10
Identities = 21/66 (31%), Positives = 30/66 (45%), Gaps = 5/66 (7%)
Query: 55 QVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGW---IP 111
+ C DPG NG R G F GS + C G+K+ + C+ +G W +P
Sbjct: 1563 EACFDPGNIMNGTRV--GTDFKLGSTITYQCDSGYKILDPSSITCVIGADGKPSWDQVLP 1620
Query: 112 SDNSIC 117
S N+ C
Sbjct: 1621 SCNAPC 1626
Score = 34.7 bits (78), Expect = 0.10
Identities = 19/54 (35%), Positives = 25/54 (46%), Gaps = 3/54 (5%)
Query: 62 IPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGW---IPS 112
+PE + G F GS+ RF C G+ L+G+T C N W IPS
Sbjct: 1745 VPEPRYGRRIGSEFSAGSIVRFECNPGYLLQGSTALHCQSVPNALAQWNDTIPS 1798
Score = 34.3 bits (77), Expect = 0.13
Identities = 17/46 (36%), Positives = 21/46 (45%), Gaps = 4/46 (8%)
Query: 198 TSFPVGTVISYRCFPGFKLDGSAYLECL----QNLIWSSSPPRCLA 239
T F +G I Y C PG+ L+G A L C+ W P C A
Sbjct: 159 TRFNIGDKIRYSCLPGYILEGHAILTCIVSPGNGASWDFPAPFCRA 204
Score = 33.9 bits (76), Expect = 0.17
Identities = 14/41 (34%), Positives = 22/41 (53%)
Query: 198 TSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCL 238
+SF G +++ C F+L G + C QN WS + P C+
Sbjct: 542 SSFLHGDTLTFECPAAFELVGERVITCQQNNQWSGNKPSCV 582
Score = 32.7 bits (73), Expect = 0.38
Identities = 14/45 (31%), Positives = 25/45 (55%), Gaps = 4/45 (8%)
Query: 198 TSFPVGTVISYRCFPGFKLDGSAYLEC--LQNLI--WSSSPPRCL 238
+ F G+++ + C PG+ L GS L C + N + W+ + P C+
Sbjct: 1756 SEFSAGSIVRFECNPGYLLQGSTALHCQSVPNALAQWNDTIPSCV 1800
Score = 30.8 bits (68), Expect = 1.5
Identities = 13/47 (27%), Positives = 22/47 (46%), Gaps = 2/47 (4%)
Query: 54 LQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCL 100
L C +P +P N + G + V F C+ G+ L+G + C+
Sbjct: 1913 LAACQEPALPSNSIKI--GDRYMVNDVLSFQCEPGYTLQGRSHISCM 1957
Score = 30.4 bits (67), Expect = 1.9
Identities = 19/71 (26%), Positives = 32/71 (45%), Gaps = 8/71 (11%)
Query: 178 QGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNL----IWSSS 233
+ C P NG + + T F +G+ I+Y+C G+K+ + + C+ W
Sbjct: 1563 EACFDPGNIMNG----TRVGTDFKLGSTITYQCDSGYKILDPSSITCVIGADGKPSWDQV 1618
Query: 234 PPRCLALEGGR 244
P C A GG+
Sbjct: 1619 LPSCNAPCGGQ 1629
Score = 30.4 bits (67), Expect = 1.9
Identities = 15/42 (35%), Positives = 21/42 (50%), Gaps = 2/42 (4%)
Query: 200 FPVGTVISYRCFPGFKLDGSAYLEC--LQNLIWSSSPPRCLA 239
F +G + Y+C PG+ L G+ L C L + S P C A
Sbjct: 2277 FEIGDFVKYQCHPGYTLVGTDILTCKLSSQLQFEGSLPTCEA 2318
>gi|110611237 coagulation factor XIII B subunit precursor [Homo
sapiens]
Length = 661
Score = 70.1 bits (170), Expect = 2e-12
Identities = 53/193 (27%), Positives = 80/193 (41%), Gaps = 26/193 (13%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C+ + ENG+ P + EG V +F C + + L G+ C GW P ++ +
Sbjct: 213 CSSLRLIENGYFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCY-----NFGWYP-ESPV 266
Query: 117 CVQEDCR-----IPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTW 171
C R +P + H+ TYRHGE + I C F+I H + +DG W
Sbjct: 267 CEGRRNRCPPPPLPINSKIQTHSTTYRHGEIVHIECELNFEI-----HGSAEIRCEDGKW 321
Query: 172 NNLPIC------QGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECL 225
P C C P NG N+ + G ++Y C G+ L GS + C
Sbjct: 322 TEPPKCIEGQEKVACEEPPFIENGAANLH--SKIYYNGDKVTYACKSGYLLHGSNEITCN 379
Query: 226 QNLIWSSSPPRCL 238
+ W + PP C+
Sbjct: 380 RGK-W-TLPPECV 390
Score = 38.1 bits (87), Expect = 0.009
Identities = 48/202 (23%), Positives = 78/202 (38%), Gaps = 38/202 (18%)
Query: 57 CADPGIPENGFRTPSGGV---FFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSD 113
C P + NG + G+ + GS + C + + L+G+ C + W S
Sbjct: 396 CKHPPVVMNG--AVADGILASYATGSSVEYRCNEYYLLRGSKISRCEQG-----KW--SS 446
Query: 114 NSICVQEDCRIP-------QIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCR 166
+C+ E C + IE + HG+ + C +G+ DL + L
Sbjct: 447 PPVCL-EPCTVNVDYMNRNNIEMKWKYEGKVLHGDLIDFVCKQGY-----DLSPLTPLSE 500
Query: 167 DDGTWNN----LPICQG------CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKL 216
N P+C C P +G + IS ++ G+ + YRCF L
Sbjct: 501 LSVQCNRGEVKYPLCTRKESKGMCTSPPLIKHGVI-ISSTVDTYENGSSVEYRCFDHHFL 559
Query: 217 DGSAYLECLQNLIWSSSPPRCL 238
+GS CL + W ++PP CL
Sbjct: 560 EGSREAYCLDGM-W-TTPPLCL 579
Score = 35.4 bits (80), Expect = 0.059
Identities = 38/147 (25%), Positives = 59/147 (40%), Gaps = 17/147 (11%)
Query: 100 LKHFNGTLGWIPSDNSICVQEDCRIPQIEDAEIHNKTYRH---------GEKLIITCHEG 150
LK+ + I S ++ C P +E+ I Y +KL C G
Sbjct: 3 LKNLTFIIILIISGELYAEEKPCGFPHVENGRIAQYYYTFKSFYFPMSIDKKLSFFCLAG 62
Query: 151 FKIRYPDLHNMVSLCRDDGTWNNLPIC-QGCLRPLASSNGYVNISELQTSFPVGTVISYR 209
+ + C +G W+ P C + C +P SNGY IS+++ + + + Y
Sbjct: 63 YTTESGRQEEQTT-CTTEG-WSPEPRCFKKCTKP-DLSNGY--ISDVKLLYKIQENMRYG 117
Query: 210 CFPGFKLDGSAYLECLQNLI--WSSSP 234
C G+K G E +Q L WSS P
Sbjct: 118 CASGYKTTGGKDEEVVQCLSDGWSSQP 144
>gi|62739186 complement factor H isoform a precursor [Homo sapiens]
Length = 1231
Score = 68.9 bits (167), Expect = 5e-12
Identities = 56/194 (28%), Positives = 90/194 (46%), Gaps = 25/194 (12%)
Query: 54 LQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSD 113
+Q+C P N + + +G CQ+ + ++ + C +G IP
Sbjct: 808 IQLCPPPPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGEEITCK---DGRWQSIP-- 862
Query: 114 NSICVQE-DC-RIPQIEDAEIHN-----KTYRHGEKLIITCHEGFKIRYPDLHNMVSLCR 166
+CV++ C + PQIE I++ ++Y HG KL TC GF+I +
Sbjct: 863 --LCVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCYM--- 917
Query: 167 DDGTWNNLPICQG--CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLEC 224
G W++ P C+G C P S+G V + + S+ G ++Y+CF GF +DG A +C
Sbjct: 918 --GKWSSPPQCEGLPCKSPPEISHGVV--AHMSDSYQYGEEVTYKCFEGFGIDGPAIAKC 973
Query: 225 LQNLIWSSSPPRCL 238
L W S PP C+
Sbjct: 974 LGEK-W-SHPPSCI 985
Score = 62.4 bits (150), Expect = 5e-10
Identities = 45/183 (24%), Positives = 79/183 (43%), Gaps = 25/183 (13%)
Query: 77 EGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDN-SICVQEDCRIPQIEDAEIHNK 135
EG+ A + C+ G++ G +C K W+ + C + C P
Sbjct: 44 EGTQAIYKCRPGYRSLGNVIMVCRKG-----EWVALNPLRKCQKRPCGHPGDTPFGTFTL 98
Query: 136 T----YRHGEKLIITCHEGFK----IRYPDLHNMVSLCRDDGTWNNLPICQ--GCLRPLA 185
T + +G K + TC+EG++ I Y + C DG N++PIC+ CL A
Sbjct: 99 TGGNVFEYGVKAVYTCNEGYQLLGEINYRE-------CDTDGWTNDIPICEVVKCLPVTA 151
Query: 186 SSNGYVNISELQTS--FPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLALEGG 243
NG + S ++ + G + + C G+K++G + C + WS P+C+ +
Sbjct: 152 PENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCK 211
Query: 244 RPE 246
P+
Sbjct: 212 SPD 214
Score = 52.4 bits (124), Expect = 5e-07
Identities = 45/187 (24%), Positives = 77/187 (41%), Gaps = 21/187 (11%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C P +G + G + C +GF + G CL W S
Sbjct: 931 CKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCLGE-----KW--SHPPS 983
Query: 117 CVQEDC-RIPQIEDAEIHNK---TYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWN 172
C++ DC +P E+A + Y+ GE++ TC +K+ N+ + + W
Sbjct: 984 CIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCATYYKM--DGASNVTCI---NSRWT 1038
Query: 173 NLPICQ--GCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIW 230
P C+ C+ P N Y+ +S + +P G + Y+C +++ G + CL N W
Sbjct: 1039 GRPTCRDTSCVNPPTVQNAYI-VSRQMSKYPSGERVRYQCRSPYEMFGDEEVMCL-NGNW 1096
Query: 231 SSSPPRC 237
+ PP+C
Sbjct: 1097 -TEPPQC 1102
Score = 50.4 bits (119), Expect = 2e-06
Identities = 49/207 (23%), Positives = 83/207 (40%), Gaps = 30/207 (14%)
Query: 50 GFDDLQVCAD-----PGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFN 104
G+ DL +C + P I + + G V +F C+ GF + G C HF
Sbjct: 557 GWSDLPICYERECELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCY-HFG 615
Query: 105 GTLGWIPSDNSIC---VQEDCRIPQIEDAEIHNKT---YRHGEKLIITCHEGFKIRYPDL 158
+ D IC VQ P++ + + KT Y H E + C+ F ++ P+
Sbjct: 616 -----LSPDLPICKEQVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNK 670
Query: 159 HNMVSLCRDDGTWNNLPIC----QGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGF 214
V DG W LP+C C +G+ +S + G + + C F
Sbjct: 671 IQCV-----DGEWTTLPVCIVEESTCGDIPELEHGWAQLS--SPPYYYGDSVEFNCSESF 723
Query: 215 KLDGSAYLECLQNLIWSSSPPRCLALE 241
+ G + C+ +W+ P+C+A++
Sbjct: 724 TMIGHRSITCIHG-VWTQL-PQCVAID 748
Score = 48.1 bits (113), Expect = 9e-06
Identities = 44/186 (23%), Positives = 81/186 (43%), Gaps = 22/186 (11%)
Query: 57 CADPGIPENGFRTPSGGV---FFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSD 113
C+ P E+G S + G+ + C+ GF++ + C + G P
Sbjct: 870 CSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTC---YMGKWSSPPQ- 925
Query: 114 NSICVQEDCRIP-QIEDAEIHNKT--YRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGT 170
C C+ P +I + + + Y++GE++ C EGF I P ++ C +
Sbjct: 926 ---CEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGP----AIAKCLGE-K 977
Query: 171 WNNLPIC--QGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNL 228
W++ P C CL L S + + E + + G ++Y C +K+DG++ + C+ N
Sbjct: 978 WSHPPSCIKTDCLS-LPSFENAIPMGEKKDVYKAGEQVTYTCATYYKMDGASNVTCI-NS 1035
Query: 229 IWSSSP 234
W+ P
Sbjct: 1036 RWTGRP 1041
Score = 46.2 bits (108), Expect = 3e-05
Identities = 41/174 (23%), Positives = 75/174 (43%), Gaps = 10/174 (5%)
Query: 54 LQVCADPGIP-ENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPS 112
++ C+ I ENGF + S + A++ C+ G+ + G GW S
Sbjct: 445 VKTCSKSSIDIENGFISESQYTYALKEKAKYQCKLGYVTADGETSGSITC--GKDGW--S 500
Query: 113 DNSICVQEDCRIPQIEDAEIHNKT--YRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGT 170
C++ C IP +A N ++ + L CH+G++ + +C +G
Sbjct: 501 AQPTCIKS-CDIPVFMNARTKNDFTWFKLNDTLDYECHDGYESNTGSTTGSI-VCGYNG- 557
Query: 171 WNNLPICQGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLEC 224
W++LPIC L + ++ + + VG V+ + C PGF + G ++C
Sbjct: 558 WSDLPICYERECELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQC 611
Score = 36.2 bits (82), Expect = 0.035
Identities = 36/136 (26%), Positives = 67/136 (49%), Gaps = 19/136 (13%)
Query: 108 GWIPSDNSICVQEDCRIPQIEDA--EIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLC 165
GW P+ C+++ C P +E+ + H + + G+ + + CH G+ + P V+ C
Sbjct: 378 GWSPAVP--CLRK-CYFPYLENGYNQNHGRKFVQGKSIDVACHPGYAL--PKAQTTVT-C 431
Query: 166 RDDGTWNNLPIC---QGCLR-PLASSNGYVNISELQTSFPVGTVISYRCFPGF-KLDG-- 218
++G W+ P C + C + + NG+ ISE Q ++ + Y+C G+ DG
Sbjct: 432 MENG-WSPTPRCIRVKTCSKSSIDIENGF--ISESQYTYALKEKAKYQCKLGYVTADGET 488
Query: 219 SAYLECLQNLIWSSSP 234
S + C ++ WS+ P
Sbjct: 489 SGSITCGKD-GWSAQP 503
>gi|13540563 complement factor H-related 5 [Homo sapiens]
Length = 569
Score = 68.9 bits (167), Expect = 5e-12
Identities = 64/215 (29%), Positives = 99/215 (46%), Gaps = 35/215 (16%)
Query: 34 LWFQLALCFGPAQLTGGFDDLQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKG 93
+W +L +C QL + C G+ SG F S R+ C D F+ +
Sbjct: 315 IWTELPMCVATHQL-------KRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRH 367
Query: 94 ATKRLCLKHFNGTLGWIPSDNSICVQEDCRI----PQIEDAEIHNKT--YRHGEKLIITC 147
+ +C+ NG W P + C ++ + PQI +A+ T Y+ GEK+ + C
Sbjct: 368 S---VCI---NGK--WNPEVD--CTEKREQFCPPPPQIPNAQNMTTTVNYQDGEKVAVLC 417
Query: 148 HEGFKIRYPDLHNMVSLCRDDGTWNNLPICQG----CLRPLASSNGYVNISELQTSFPVG 203
E + + P+ +V C+D G W +LP C C P + +NG L +P G
Sbjct: 418 KENYLL--PEAKEIV--CKD-GRWQSLPRCVESTAYCGPPPSINNGDTTSFPLSV-YPPG 471
Query: 204 TVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCL 238
+ ++YRC +KL GS + C +N W S PPRCL
Sbjct: 472 STVTYRCQSFYKLQGSVTVTC-RNKQW-SEPPRCL 504
Score = 55.8 bits (133), Expect = 4e-08
Identities = 48/189 (25%), Positives = 84/189 (44%), Gaps = 20/189 (10%)
Query: 54 LQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRL-CLKHFNGTLGWIPS 112
L++C+ P + +NG SG + EG + C G+ L+ K + C++ GW
Sbjct: 84 LRMCSFPFV-KNGHSESSGLIHLEGDTVQIICNTGYSLQNNEKNISCVER-----GWSTP 137
Query: 113 DNSICVQEDCRIPQIE---DAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDG 169
+ +C +P +E DA+ ++Y+ G+ L +C + IR + + C G
Sbjct: 138 PICSFTKGECHVPILEANVDAQPKKESYKVGDVLKFSCRKNL-IR---VGSDSVQCYQFG 193
Query: 170 TWNNLPICQG----CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECL 225
N P C+G C P SNG V + + V+ Y C P F ++G ++C+
Sbjct: 194 WSPNFPTCKGQVRSCGPPPQLSNGEVK-EIRKEEYGHNEVVEYDCNPNFIINGPKKIQCV 252
Query: 226 QNLIWSSSP 234
W++ P
Sbjct: 253 DG-EWTTLP 260
Score = 40.0 bits (92), Expect = 0.002
Identities = 49/194 (25%), Positives = 73/194 (37%), Gaps = 27/194 (13%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C P + N P + G V +F C+ G+ C + GW P+ +
Sbjct: 147 CHVPILEANVDAQPKKESYKVGDVLKFSCRKNLIRVGSDSVQCYQ-----FGWSPNFPTC 201
Query: 117 CVQ-EDCRIPQI----EDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTW 171
Q C P E EI + Y H E + C+ F I P V DG W
Sbjct: 202 KGQVRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNPNFIINGPKKIQCV-----DGEW 256
Query: 172 NNLPICQGCLRPLASSNGYVNISE---LQTSFPV---GTVISYRCFPGFKLDGSAYLECL 225
LP C ++ + GY+ E +Q S P G + C + + G+ + C+
Sbjct: 257 TTLPTCVEQVK----TCGYIPELEYGYVQPSVPPYQHGVSVEVNCRNEYAMIGNNMITCI 312
Query: 226 QNLIWSSSPPRCLA 239
N IW+ P C+A
Sbjct: 313 -NGIWTEL-PMCVA 324
>gi|157419154 selectin P precursor [Homo sapiens]
Length = 830
Score = 68.6 bits (166), Expect = 6e-12
Identities = 49/176 (27%), Positives = 79/176 (44%), Gaps = 17/176 (9%)
Query: 73 GVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDC---RIPQIED 129
G F S FHC DG+++ G +K CL G + C+ C +IP+ +
Sbjct: 218 GNFSFNSQCSFHCTDGYQVNGPSKLECLAS-----GIWTNKPPQCLAAQCPPLKIPERGN 272
Query: 130 AE-IHN-KTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNN-LPICQG--CLRPL 184
+H+ K ++H +C EGF + P+ V C G W P+C+ C
Sbjct: 273 MTCLHSAKAFQHQSSCSFSCEEGFALVGPE----VVQCTASGVWTAPAPVCKAVQCQHLE 328
Query: 185 ASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLAL 240
A S G ++ T+F G+ + C PG+++ G L C+ + WS+ P C A+
Sbjct: 329 APSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAI 384
Score = 62.8 bits (151), Expect = 3e-10
Identities = 47/172 (27%), Positives = 76/172 (44%), Gaps = 13/172 (7%)
Query: 75 FFEGSVARFHCQDGFKLKGATKRLCLK--HFNGTLGWIPSDNSI-CVQEDCRIPQIEDAE 131
F GS +F CQ G++++G C+ H++ L P+ +I C + + D
Sbjct: 344 FAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPL---PTCEAISCEPLESPVHGSMDCS 400
Query: 132 IHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNN-LPICQG--CLRPLASSN 188
+ +++ C EGF +R D+ C + G W P+CQ C +
Sbjct: 401 PSLRAFQYDTNCSFRCAEGFMLRGADIVR----CDNLGQWTAPAPVCQALQCQDLPVPNE 456
Query: 189 GYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLAL 240
VN S +F +V S+ C G L G++ L+CL W+S PP C A+
Sbjct: 457 ARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAI 508
Score = 60.8 bits (146), Expect = 1e-09
Identities = 47/172 (27%), Positives = 74/172 (43%), Gaps = 15/172 (8%)
Query: 73 GVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDCRIPQIEDAE- 131
G F SV F C +G L GA+ CL G +P + PQ
Sbjct: 466 GAFRYQSVCSFTCNEGLLLVGASVLQCLA--TGNWNSVPPECQAIPCTPLLSPQNGTMTC 523
Query: 132 ---IHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNLP-ICQG--CLRPLA 185
+ + +Y+ + I C EG+ + P+ + C G W + P +C+ C A
Sbjct: 524 VQPLGSSSYKSTCQFI--CDEGYSLSGPERLD----CTRSGRWTDSPPMCEAIKCPELFA 577
Query: 186 SSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRC 237
G ++ S+ + F VG+ + C GFKL+G +EC + WS++PP C
Sbjct: 578 PEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTC 629
Score = 58.9 bits (141), Expect = 5e-09
Identities = 47/181 (25%), Positives = 77/181 (42%), Gaps = 17/181 (9%)
Query: 69 TPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDCR-IPQI 127
+PS F + F C +GF L+GA C LG + +C C+ +P
Sbjct: 400 SPSLRAFQYDTNCSFRCAEGFMLRGADIVRC-----DNLGQWTAPAPVCQALQCQDLPVP 454
Query: 128 EDAEIHNK----TYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNLPI-CQG--C 180
+A ++ +R+ TC+EG + + V C G WN++P CQ C
Sbjct: 455 NEARVNCSHPFGAFRYQSVCSFTCNEGLLL----VGASVLQCLATGNWNSVPPECQAIPC 510
Query: 181 LRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLAL 240
L+ NG + + S + + C G+ L G L+C ++ W+ SPP C A+
Sbjct: 511 TPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAI 570
Query: 241 E 241
+
Sbjct: 571 K 571
Score = 58.2 bits (139), Expect = 9e-09
Identities = 51/196 (26%), Positives = 76/196 (38%), Gaps = 17/196 (8%)
Query: 57 CADPGIPENGFRTPSG--GVFFEGSVARFHCQDGFKLKGATKRLCLK--HFNGT------ 106
C + PE G S G F GS F C +GFKL+G C ++ T
Sbjct: 572 CPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKG 631
Query: 107 LGWIPSDNSICVQEDCRIPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCR 166
+ +P+ C H T+ C+ GF + + + CR
Sbjct: 632 IASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTL----IGDSTLSCR 687
Query: 167 DDGTWNNL-PICQG--CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLE 223
G W + P C+ C + +N S L +F G++ S+ C G L+GSA
Sbjct: 688 PSGQWTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGSICSFHCLEGQLLNGSAQTA 747
Query: 224 CLQNLIWSSSPPRCLA 239
C +N WS++ P C A
Sbjct: 748 CQENGHWSTTVPTCQA 763
Score = 55.1 bits (131), Expect = 7e-08
Identities = 53/195 (27%), Positives = 78/195 (40%), Gaps = 19/195 (9%)
Query: 57 CADPGIPENGFRT--PSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDN 114
C IPE G T S F S F C++GF L G C G +
Sbjct: 262 CPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTAS-----GVWTAPA 316
Query: 115 SICVQEDCRIPQIEDAE----IHNKT-YRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDG 169
+C C+ + +H T + +G C G+++R D+ C D G
Sbjct: 317 PVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLR----CIDSG 372
Query: 170 TWNN-LPICQGC-LRPLASS-NGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQ 226
W+ LP C+ PL S +G ++ S +F T S+RC GF L G+ + C
Sbjct: 373 HWSAPLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCAEGFMLRGADIVRCDN 432
Query: 227 NLIWSSSPPRCLALE 241
W++ P C AL+
Sbjct: 433 LGQWTAPAPVCQALQ 447
Score = 44.3 bits (103), Expect = 1e-04
Identities = 18/51 (35%), Positives = 32/51 (62%)
Query: 191 VNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLALE 241
+N S +F + S+ C G++++G + LECL + IW++ PP+CLA +
Sbjct: 211 MNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQ 261
Score = 43.5 bits (101), Expect = 2e-04
Identities = 47/200 (23%), Positives = 74/200 (37%), Gaps = 33/200 (16%)
Query: 63 PENGFRT---PSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQ 119
P+NG T P G ++ S +F C +G+ L G + C + T +S +
Sbjct: 516 PQNGTMTCVQPLGSSSYK-STCQFICDEGYSLSGPERLDCTRSGRWT-------DSPPMC 567
Query: 120 EDCRIPQIE-------DAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWN 172
E + P++ D + G +C GFK+ P N V C G W+
Sbjct: 568 EAIKCPELFAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGP---NNVE-CTTSGRWS 623
Query: 173 NLP-ICQG----------CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAY 221
P C+G C G + +F T + C GF L G +
Sbjct: 624 ATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDST 683
Query: 222 LECLQNLIWSSSPPRCLALE 241
L C + W++ P C A++
Sbjct: 684 LSCRPSGQWTAVTPACRAVK 703
>gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens]
Length = 3487
Score = 66.6 bits (161), Expect = 2e-11
Identities = 47/127 (37%), Positives = 61/127 (48%), Gaps = 12/127 (9%)
Query: 54 LQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSD 113
L CADPG+P+ G + S G + GS F CQ G+ L+G+T R CL N T P D
Sbjct: 3128 LTTCADPGVPQFGIQNNSQG-YQVGSTVLFRCQKGYLLQGSTTRTCLP--NLTWSGTPPD 3184
Query: 114 NSICVQEDCRIPQI-EDAEIHNKTY-RHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTW 171
CV CR P+ A + G LI +C EGF ++ H C+ DG+W
Sbjct: 3185 ---CVPHHCRQPETPTHANVGALDLPSMGYTLIYSCQEGFSLKGGSEHR---TCKADGSW 3238
Query: 172 NNL-PIC 177
PIC
Sbjct: 3239 TGKPPIC 3245
Score = 65.5 bits (158), Expect = 5e-11
Identities = 55/192 (28%), Positives = 81/192 (42%), Gaps = 22/192 (11%)
Query: 56 VCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNS 115
VC DPGIP +G R G F G+V RF C+ G L+G+++R C NG+ W S
Sbjct: 2834 VCGDPGIPAHGIRL--GDSFDPGTVMRFSCEAGHVLRGSSERTC--QANGS--WSGSQPE 2887
Query: 116 ICVQEDCRIPQIED--AEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNN 173
C C P + + ++ C EG Y + C +GTW
Sbjct: 2888 -CGVISCGNPGTPSNARVVFSDGLVFSSSIVYECREG----YYATGLLSRHCSVNGTWTG 2942
Query: 174 L-PICQ--GCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGS--AYLECLQNL 228
P C C P +NG L F ++Y+C PG+ ++ + L C ++
Sbjct: 2943 SDPECLVINCGDPGIPANGL----RLGNDFRYNKTVTYQCVPGYMMESHRVSVLSCTKDR 2998
Query: 229 IWSSSPPRCLAL 240
W+ + P C AL
Sbjct: 2999 TWNGTKPVCKAL 3010
Score = 63.5 bits (153), Expect = 2e-10
Identities = 54/197 (27%), Positives = 87/197 (44%), Gaps = 20/197 (10%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTL-GWIPS--D 113
C DPG+P G R G F S F C L G+ +R C +GT G PS D
Sbjct: 3070 CGDPGVPSRGRREDRG--FSYRSSVSFSCHPPLVLVGSPRRFCQS--DGTWSGTQPSCID 3125
Query: 114 NSICVQEDCRIPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNN 173
++ D +PQ + +++ Y+ G ++ C +G+ ++ + C + TW+
Sbjct: 3126 PTLTTCADPGVPQF-GIQNNSQGYQVGSTVLFRCQKGYLLQ----GSTTRTCLPNLTWSG 3180
Query: 174 LP---ICQGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDG-SAYLECLQNLI 229
P + C +P ++ V +L + +G + Y C GF L G S + C +
Sbjct: 3181 TPPDCVPHHCRQPETPTHANVGALDLPS---MGYTLIYSCQEGFSLKGGSEHRTCKADGS 3237
Query: 230 WSSSPPRCLALE-GGRP 245
W+ PP CL + GRP
Sbjct: 3238 WTGKPPICLEVRPSGRP 3254
Score = 61.6 bits (148), Expect = 8e-10
Identities = 50/198 (25%), Positives = 80/198 (40%), Gaps = 21/198 (10%)
Query: 56 VCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNS 115
+C P + NG G F GS + C +G++L C + + T G +P
Sbjct: 3011 MCKPPPLIPNG--KVVGSDFMWGSSVTYACLEGYQLSLPAVFTCEGNGSWT-GELPQ--- 3064
Query: 116 ICVQEDCRIPQIED-AEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNL 174
C C P + ++ + + + +CH + + + C+ DGTW+
Sbjct: 3065 -CFPVFCGDPGVPSRGRREDRGFSYRSSVSFSCHPPLVL----VGSPRRFCQSDGTWSGT 3119
Query: 175 ------PICQGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNL 228
P C P G N S+ + VG+ + +RC G+ L GS CL NL
Sbjct: 3120 QPSCIDPTLTTCADPGVPQFGIQNNSQ---GYQVGSTVLFRCQKGYLLQGSTTRTCLPNL 3176
Query: 229 IWSSSPPRCLALEGGRPE 246
WS +PP C+ +PE
Sbjct: 3177 TWSGTPPDCVPHHCRQPE 3194
Score = 60.1 bits (144), Expect = 2e-09
Identities = 45/196 (22%), Positives = 78/196 (39%), Gaps = 13/196 (6%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C+ P P +GF GS+ F C G++L G + +C +H G W + +
Sbjct: 2468 CSLPRAPLHGFILGQTSTQPGGSI-HFGCNAGYRLVGHSMAICTRHPQGYHLWSEA-IPL 2525
Query: 117 CVQEDCRIPQI-EDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNLP 175
C C +P+ ++ + K Y G K + +C EG+ ++ + C D G W+N
Sbjct: 2526 CQALSCGLPEAPKNGMVFGKEYTVGTKAMYSCSEGYHLQAG--AEATAECLDTGLWSNRN 2583
Query: 176 ICQGCLRPLASSNGYVNISE------LQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLI 229
+ C+ +++ +T + + C PG+ G + C N
Sbjct: 2584 VPPQCVPVTCPDVSSISVEHGRWRLIFETQYQFQAQLMLICDPGYYYTGQRVIRCQANGK 2643
Query: 230 WS--SSPPRCLALEGG 243
WS S P C + G
Sbjct: 2644 WSLGDSTPTCRIISCG 2659
Score = 59.3 bits (142), Expect = 4e-09
Identities = 64/250 (25%), Positives = 90/250 (36%), Gaps = 72/250 (28%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C + IP NG R + V+ G+ A F C G+ L G+ R C+ NG W S+
Sbjct: 2658 CGELPIPPNGHRIGTLSVY--GATAIFSCNSGYTLVGSRVRECMA--NGL--WSGSEVR- 2710
Query: 117 CVQEDCRIPQ-IEDAEIHNKTYRHGEKLIITCHEGF-------KIRYPDLH--------- 159
C+ C P+ I + I+ + Y + ++ C+ GF +I D H
Sbjct: 2711 CLAGHCGTPEPIVNGHINGENYSYRGSVVYQCNAGFRLIGMSVRICQQDHHWSGKTPFCV 2770
Query: 160 --------------------------------------NMVSLCRDDGTWN-NLPICQG- 179
N +C DG W +LP C G
Sbjct: 2771 LVSCGHPGSPPHSQMSGDSYTVGAVVRYSCIGKRTLVGNSTRMCGLDGHWTGSLPHCSGT 2830
Query: 180 ----CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPP 235
C P ++G L SF GTV+ + C G L GS+ C N WS S P
Sbjct: 2831 SVGVCGDPGIPAHGI----RLGDSFDPGTVMRFSCEAGHVLRGSSERTCQANGSWSGSQP 2886
Query: 236 RCLALEGGRP 245
C + G P
Sbjct: 2887 ECGVISCGNP 2896
Score = 58.2 bits (139), Expect = 9e-09
Identities = 50/190 (26%), Positives = 74/190 (38%), Gaps = 25/190 (13%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKG--ATKRLCLKH--FNGTLGWIPS 112
C DPGIP NG R G F + C G+ ++ + C K +NGT
Sbjct: 2952 CGDPGIPANGLRL--GNDFRYNKTVTYQCVPGYMMESHRVSVLSCTKDRTWNGT------ 3003
Query: 113 DNSICVQEDCRIPQ-IEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTW 171
+C C+ P I + ++ + G + C EG+++ P V C +G+W
Sbjct: 3004 -KPVCKALMCKPPPLIPNGKVVGSDFMWGSSVTYACLEGYQLSLP----AVFTCEGNGSW 3058
Query: 172 -NNLPIC--QGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNL 228
LP C C P S G F + +S+ C P L GS C +
Sbjct: 3059 TGELPQCFPVFCGDPGVPSRG----RREDRGFSYRSSVSFSCHPPLVLVGSPRRFCQSDG 3114
Query: 229 IWSSSPPRCL 238
WS + P C+
Sbjct: 3115 TWSGTQPSCI 3124
Score = 52.8 bits (125), Expect = 4e-07
Identities = 52/205 (25%), Positives = 80/205 (39%), Gaps = 30/205 (14%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRL--CLKHFNGTLGWIPSDN 114
C P P+NG G + G+ A + C +G+ L+ + CL + +P
Sbjct: 2531 CGLPEAPKNGM--VFGKEYTVGTKAMYSCSEGYHLQAGAEATAECLDTGLWSNRNVPPQ- 2587
Query: 115 SICVQEDCRIPQIEDAEIHN--------KTYRHGEKLIITCHEGFKIRYPDLHNMVSLCR 166
CV C P + + + Y+ +L++ C G Y V C+
Sbjct: 2588 --CVPVTC--PDVSSISVEHGRWRLIFETQYQFQAQLMLICDPG----YYYTGQRVIRCQ 2639
Query: 167 DDGTWN---NLPICQ--GCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAY 221
+G W+ + P C+ C NG+ + T G + C G+ L GS
Sbjct: 2640 ANGKWSLGDSTPTCRIISCGELPIPPNGH----RIGTLSVYGATAIFSCNSGYTLVGSRV 2695
Query: 222 LECLQNLIWSSSPPRCLALEGGRPE 246
EC+ N +WS S RCLA G PE
Sbjct: 2696 RECMANGLWSGSEVRCLAGHCGTPE 2720
Score = 50.4 bits (119), Expect = 2e-06
Identities = 53/195 (27%), Positives = 78/195 (40%), Gaps = 19/195 (9%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLK--HFNGTLGWIPSDN 114
C PG P + SG + G+V R+ C L G + R+C H+ G+L S
Sbjct: 2774 CGHPGSPPHS--QMSGDSYTVGAVVRYSCIGKRTLVGNSTRMCGLDGHWTGSLPHC-SGT 2830
Query: 115 SICVQEDCRIPQIEDAEIH-NKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWN- 172
S+ V C P I I ++ G + +C G +R + C+ +G+W+
Sbjct: 2831 SVGV---CGDPGIPAHGIRLGDSFDPGTVMRFSCEAGHVLR----GSSERTCQANGSWSG 2883
Query: 173 NLPICQ--GCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIW 230
+ P C C P SN V S+ + I Y C G+ G C N W
Sbjct: 2884 SQPECGVISCGNPGTPSNARVVFSD---GLVFSSSIVYECREGYYATGLLSRHCSVNGTW 2940
Query: 231 SSSPPRCLALEGGRP 245
+ S P CL + G P
Sbjct: 2941 TGSDPECLVINCGDP 2955
Score = 48.5 bits (114), Expect = 7e-06
Identities = 27/78 (34%), Positives = 40/78 (51%), Gaps = 6/78 (7%)
Query: 180 CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLI--WSSSPPRC 237
C P SNG V E + V V+S++C PG+ L G A++ C+ + W+ PP C
Sbjct: 1909 CPEPAVPSNG-VKTGE---RYLVNDVVSFQCEPGYALQGHAHISCMPGTVRRWNYPPPLC 1964
Query: 238 LALEGGRPEHLFPVLYFP 255
+A GG E + V+ P
Sbjct: 1965 IAQCGGTVEEMEGVILSP 1982
Score = 48.1 bits (113), Expect = 9e-06
Identities = 63/242 (26%), Positives = 93/242 (38%), Gaps = 67/242 (27%)
Query: 56 VCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLK-------------- 101
+C DPGIPE G R G F GS +F C +G+ L+G+ + C+K
Sbjct: 342 MCPDPGIPERGKRL--GSDFRLGSSVQFTCNEGYDLQGSKRITCMKVSDMFAAWSDHRPV 399
Query: 102 --------HFNGTLGWIPS--------DNSICV-----QEDCRIPQIE----DAEIHNKT 136
H G G I S +N+ CV ++ ++ D E T
Sbjct: 400 CRARMCDAHLRGPSGIITSPNFPIQYDNNAHCVWIITALNPSKVIKLAFEEFDLERGYDT 459
Query: 137 YRHG-------EKLIITCHEGFKIRYPDL-----HNMVSLCRDDGTWNNL-------PIC 177
G +K ++ G + PDL H M L + DG+ ++L I
Sbjct: 460 LTVGDGGQDGDQKTVLYILTGTSV--PDLIVSTNHQMWLLFQTDGSGSSLGFKASYEEIE 517
Query: 178 QG-CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPR 236
QG C P + G S F G + + C P F+L G + C +N WS+ P
Sbjct: 518 QGSCGDPGIPAYGRREGSR----FHHGDTLKFECQPAFELVGQKAITCQKNNQWSAKKPG 573
Query: 237 CL 238
C+
Sbjct: 574 CV 575
Score = 46.6 bits (109), Expect = 3e-05
Identities = 19/42 (45%), Positives = 30/42 (71%), Gaps = 2/42 (4%)
Query: 200 FPVGTVISYRCFPGFKLDGSAYLECL--QNLIWSSSPPRCLA 239
F VG +++ CFPG++L+G+A + CL + +WSS PRC+A
Sbjct: 1055 FGVGDTLTFSCFPGYRLEGTARITCLGGRRRLWSSPLPRCVA 1096
Score = 42.4 bits (98), Expect = 5e-04
Identities = 67/297 (22%), Positives = 93/297 (31%), Gaps = 101/297 (34%)
Query: 54 LQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKG--------ATKR-------L 98
L C +P +P NG +T G + V F C+ G+ L+G T R L
Sbjct: 1906 LSSCPEPAVPSNGVKT--GERYLVNDVVSFQCEPGYALQGHAHISCMPGTVRRWNYPPPL 1963
Query: 99 CLKHFNGTL-------------GWIPSDNSICVQEDCRI--------------PQIEDAE 131
C+ GT+ G PS+ + + P + E
Sbjct: 1964 CIAQCGGTVEEMEGVILSPGFPGNYPSNMDCSWKIALPVGFGAHIQFLNFSTEPNHDYIE 2023
Query: 132 IHNKTYRHGE------------KLIITCHE--------------GFKIRYPDL---HNMV 162
I N Y L+ T HE GFK+ Y DL H +
Sbjct: 2024 IRNGPYETSRMMGRFSGSELPSSLLSTSHETTVYFHSDHSQNRPGFKLEYQDLTYSHQIS 2083
Query: 163 SLCRD-----------------DGTWNNLPIC-----QGCLRPLASSNGYVNISELQTSF 200
S R W+ P C Q C P +NG V +
Sbjct: 2084 SFLRGFDLSELERTNSTPPVAASYVWDLDPGCEAYELQECPDPEPFANGIVR----GAGY 2139
Query: 201 PVGTVISYRCFPGFKLDGSAYLECLQ--NLIWSSSPPRCLALEGGRPEHLFPVLYFP 255
VG +++ C PG++L G L C N W P+C GG +Y P
Sbjct: 2140 NVGQSVTFECLPGYQLTGHPVLTCQHGTNRNWDHPLPKCEVPCGGNITSSNGTVYSP 2196
Score = 40.8 bits (94), Expect = 0.001
Identities = 19/48 (39%), Positives = 27/48 (56%), Gaps = 1/48 (2%)
Query: 53 DLQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCL 100
+L C DPG P+ G++ G F GS F C G+ L+G+ + LCL
Sbjct: 1207 ELIKCEDPGTPKFGYKVHDEG-HFAGSSVSFSCDPGYSLRGSEELLCL 1253
Score = 40.8 bits (94), Expect = 0.001
Identities = 22/56 (39%), Positives = 29/56 (51%), Gaps = 3/56 (5%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPS 112
C DPGIP+NG R SG + G F C G+ L+G+ + C+K W PS
Sbjct: 1385 CNDPGIPQNGSR--SGDSWEAGDSTVFQCDPGYALQGSAEISCVK-IENRFFWQPS 1437
Score = 40.4 bits (93), Expect = 0.002
Identities = 28/94 (29%), Positives = 38/94 (40%), Gaps = 19/94 (20%)
Query: 150 GFKIRYPDLHNMVSLCRDDGTWNNLPICQGCLRPLASSNGYVNISELQTSFPVGTVISYR 209
GF++RY + C D G +P VN F VG ++++
Sbjct: 852 GFQLRYETITLQSDHCLDPG----IP---------------VNGQRHGNDFYVGALVTFS 892
Query: 210 CFPGFKLDGSAYLECLQNLIWSSSPPRCLALEGG 243
C G+ L LEC N WS + P C AL GG
Sbjct: 893 CDSGYTLSDGEPLECEPNFQWSRALPSCEALCGG 926
Score = 40.0 bits (92), Expect = 0.002
Identities = 20/55 (36%), Positives = 28/55 (50%), Gaps = 3/55 (5%)
Query: 192 NISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQ---NLIWSSSPPRCLALEGG 243
N S S+ G ++C PG+ L GSA + C++ W SPP C+A GG
Sbjct: 1393 NGSRSGDSWEAGDSTVFQCDPGYALQGSAEISCVKIENRFFWQPSPPTCIAPCGG 1447
Score = 39.3 bits (90), Expect = 0.004
Identities = 21/61 (34%), Positives = 30/61 (49%), Gaps = 3/61 (4%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C DPGIP NG R G F+ G++ F C G+ L C +F + +PS ++
Sbjct: 867 CLDPGIPVNGQR--HGNDFYVGALVTFSCDSGYTLSDGEPLECEPNFQWSRA-LPSCEAL 923
Query: 117 C 117
C
Sbjct: 924 C 924
Score = 35.8 bits (81), Expect = 0.045
Identities = 18/52 (34%), Positives = 26/52 (50%), Gaps = 4/52 (7%)
Query: 196 LQTSFPVGTVISYRCFPGFKLDGSAYLECL----QNLIWSSSPPRCLALEGG 243
L + F VG ++ + C G+ L GS +ECL W+ S P C+ GG
Sbjct: 1747 LGSDFSVGAIVRFECNSGYALQGSPEIECLPVPGALAQWNVSAPTCVVPCGG 1798
Score = 34.7 bits (78), Expect = 0.10
Identities = 17/71 (23%), Positives = 37/71 (52%), Gaps = 8/71 (11%)
Query: 178 QGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECL----QNLIWSSS 233
+ C P + NG + + + +G+ ++Y C G++++G++ L C+ +W++
Sbjct: 1556 ESCFDPGSIKNG----TRVGSDLKLGSSVTYYCHGGYEVEGTSTLSCILGPDGKPVWNNP 1611
Query: 234 PPRCLALEGGR 244
P C A GG+
Sbjct: 1612 RPVCTAPCGGQ 1622
Score = 34.7 bits (78), Expect = 0.10
Identities = 16/40 (40%), Positives = 21/40 (52%), Gaps = 2/40 (5%)
Query: 200 FPVGTVISYRCFPGFKLDGSAYLECLQN--LIWSSSPPRC 237
F +G ++ YRC PGF L G+ L C L + PP C
Sbjct: 2312 FNIGDIVRYRCLPGFTLVGNEILTCKLGTYLQFEGPPPIC 2351
Score = 33.9 bits (76), Expect = 0.17
Identities = 17/43 (39%), Positives = 23/43 (53%), Gaps = 2/43 (4%)
Query: 203 GTVISYRCFPGFKLDGSAYLECL--QNLIWSSSPPRCLALEGG 243
G+ +S+ C PG+ L GS L CL + W P C+A GG
Sbjct: 1231 GSSVSFSCDPGYSLRGSEELLCLSGERRTWDRPLPTCVAECGG 1273
Score = 33.9 bits (76), Expect = 0.17
Identities = 23/71 (32%), Positives = 34/71 (47%), Gaps = 7/71 (9%)
Query: 180 CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNL----IWSSSPP 235
C P A +G++ QTS G I + C G++L G + C ++ +WS + P
Sbjct: 2468 CSLPRAPLHGFILG---QTSTQPGGSIHFGCNAGYRLVGHSMAICTRHPQGYHLWSEAIP 2524
Query: 236 RCLALEGGRPE 246
C AL G PE
Sbjct: 2525 LCQALSCGLPE 2535
Score = 32.3 bits (72), Expect = 0.50
Identities = 16/48 (33%), Positives = 23/48 (47%), Gaps = 2/48 (4%)
Query: 53 DLQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCL 100
DL+ C +P +P R G F G F C G++L+G + CL
Sbjct: 1035 DLEPCEEPEVPAYSIR--KGLQFGVGDTLTFSCFPGYRLEGTARITCL 1080
Score = 31.2 bits (69), Expect = 1.1
Identities = 13/39 (33%), Positives = 21/39 (53%)
Query: 62 IPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCL 100
+PE + G F G++ RF C G+ L+G+ + CL
Sbjct: 1738 VPEPRYGKRLGSDFSVGAIVRFECNSGYALQGSPEIECL 1776
Score = 28.9 bits (63), Expect = 5.5
Identities = 15/33 (45%), Positives = 17/33 (51%), Gaps = 2/33 (6%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGF 89
C DPG+P NG R G GS F C +GF
Sbjct: 691 CPDPGVPVNGKR--FGDSLQLGSSISFLCDEGF 721
Score = 28.5 bits (62), Expect = 7.2
Identities = 14/48 (29%), Positives = 23/48 (47%), Gaps = 4/48 (8%)
Query: 196 LQTSFPVGTVISYRCFPGFKLDGSAYLECLQ----NLIWSSSPPRCLA 239
L + F +G+ + + C G+ L GS + C++ WS P C A
Sbjct: 355 LGSDFRLGSSVQFTCNEGYDLQGSKRITCMKVSDMFAAWSDHRPVCRA 402
Score = 28.1 bits (61), Expect = 9.4
Identities = 16/53 (30%), Positives = 21/53 (39%), Gaps = 2/53 (3%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGW 109
C +PG NG + G F G R+ C GF L+G C + W
Sbjct: 139 CGNPGRLPNGIQ--QGSTFNLGDKVRYSCNLGFFLEGHAVLTCHAGSENSATW 189
>gi|166235140 seizure related 6 homolog (mouse)-like 2 isoform 4
[Homo sapiens]
Length = 809
Score = 65.9 bits (159), Expect = 4e-11
Identities = 47/161 (29%), Positives = 76/161 (47%), Gaps = 24/161 (14%)
Query: 125 PQIEDAEIHNKTYRHGEKL---IIT--CHEGFKIRYPDLHNMVSLCRDDGTWNNLP-ICQ 178
P++ E +T HG+ + ++T C G+++ D + C+ D +W+ P CQ
Sbjct: 531 PELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSD----ILTCQWDLSWSAAPPACQ 586
Query: 179 G---CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLI----WS 231
C P +NG+ S+ FPVG+ + YRC PG+ L+G+A L C WS
Sbjct: 587 KIMTCADPGEIANGHRTASD--AGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWS 644
Query: 232 SSPPRCL-----ALEGGRPEHLFPVLYFPHIRLAAAVLYFC 267
P+C L G PE+ + LY H + ++ +FC
Sbjct: 645 DRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFC 685
Score = 56.6 bits (135), Expect = 2e-08
Identities = 33/104 (31%), Positives = 48/104 (46%), Gaps = 4/104 (3%)
Query: 54 LQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSD 113
+ CADPG NG RT S F GS ++ C G+ L+GA C GT W
Sbjct: 588 IMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRV 647
Query: 114 NSICVQ-EDCRIPQIED---AEIHNKTYRHGEKLIITCHEGFKI 153
++ E C P + + ++ Y+ GE L C+EGF++
Sbjct: 648 PKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFEL 691
Score = 56.2 bits (134), Expect = 3e-08
Identities = 50/194 (25%), Positives = 80/194 (41%), Gaps = 22/194 (11%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C + PE G+RT S G G+V + C+ G++L G+ C L W + +
Sbjct: 530 CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTC----QWDLSWSAAPPAC 585
Query: 117 CVQEDCRIPQIEDAEIHNKT----YRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGT-- 170
C P E A H + G + C G+ + + + RD GT
Sbjct: 586 QKIMTCADPG-EIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAM--LTCYSRDTGTPK 642
Query: 171 WNN-LPIC----QGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECL 225
W++ +P C + CL P NGY + + + G + + C+ GF+L G + C+
Sbjct: 643 WSDRVPKCALKYEPCLNPGVPENGYQTL--YKHHYQAGESLRFFCYEGFELIGEVTITCV 700
Query: 226 QN--LIWSSSPPRC 237
W+S PP C
Sbjct: 701 PGHPSQWTSQPPLC 714
Score = 33.5 bits (75), Expect = 0.22
Identities = 21/66 (31%), Positives = 33/66 (50%), Gaps = 6/66 (9%)
Query: 180 CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNL--IWSSSPPRC 237
C P ++G V++++L P GT ++ C G++L G L CL W+ P C
Sbjct: 176 CGFPPRPAHGDVSVTDLH---PGGTA-TFHCDSGYQLQGEETLICLNGTRPSWNGETPSC 231
Query: 238 LALEGG 243
+A GG
Sbjct: 232 MASCGG 237
Score = 30.0 bits (66), Expect = 2.5
Identities = 13/29 (44%), Positives = 17/29 (58%), Gaps = 3/29 (10%)
Query: 78 GSVARFHCQDGFKLKGATKRLCLKHFNGT 106
G A FHC G++L+G +CL NGT
Sbjct: 195 GGTATFHCDSGYQLQGEETLICL---NGT 220
Score = 28.9 bits (63), Expect = 5.5
Identities = 14/57 (24%), Positives = 27/57 (47%), Gaps = 5/57 (8%)
Query: 192 NISELQTSFPVGTVISYRCFPGFKLDGSA---YLECLQ--NLIWSSSPPRCLALEGG 243
N++ + G + ++ C PG+ L+ +EC+ W+ + P C A+ GG
Sbjct: 359 NVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGG 415
>gi|166235138 seizure related 6 homolog (mouse)-like 2 isoform 3
[Homo sapiens]
Length = 840
Score = 65.9 bits (159), Expect = 4e-11
Identities = 47/161 (29%), Positives = 76/161 (47%), Gaps = 24/161 (14%)
Query: 125 PQIEDAEIHNKTYRHGEKL---IIT--CHEGFKIRYPDLHNMVSLCRDDGTWNNLP-ICQ 178
P++ E +T HG+ + ++T C G+++ D + C+ D +W+ P CQ
Sbjct: 575 PELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSD----ILTCQWDLSWSAAPPACQ 630
Query: 179 G---CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLI----WS 231
C P +NG+ S+ FPVG+ + YRC PG+ L+G+A L C WS
Sbjct: 631 KIMTCADPGEIANGHRTASD--AGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWS 688
Query: 232 SSPPRCL-----ALEGGRPEHLFPVLYFPHIRLAAAVLYFC 267
P+C L G PE+ + LY H + ++ +FC
Sbjct: 689 DRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFC 729
Score = 56.6 bits (135), Expect = 2e-08
Identities = 33/104 (31%), Positives = 48/104 (46%), Gaps = 4/104 (3%)
Query: 54 LQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSD 113
+ CADPG NG RT S F GS ++ C G+ L+GA C GT W
Sbjct: 632 IMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRV 691
Query: 114 NSICVQ-EDCRIPQIED---AEIHNKTYRHGEKLIITCHEGFKI 153
++ E C P + + ++ Y+ GE L C+EGF++
Sbjct: 692 PKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFEL 735
Score = 56.2 bits (134), Expect = 3e-08
Identities = 50/194 (25%), Positives = 80/194 (41%), Gaps = 22/194 (11%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C + PE G+RT S G G+V + C+ G++L G+ C L W + +
Sbjct: 574 CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTC----QWDLSWSAAPPAC 629
Query: 117 CVQEDCRIPQIEDAEIHNKT----YRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGT-- 170
C P E A H + G + C G+ + + + RD GT
Sbjct: 630 QKIMTCADPG-EIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAM--LTCYSRDTGTPK 686
Query: 171 WNN-LPIC----QGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECL 225
W++ +P C + CL P NGY + + + G + + C+ GF+L G + C+
Sbjct: 687 WSDRVPKCALKYEPCLNPGVPENGYQTL--YKHHYQAGESLRFFCYEGFELIGEVTITCV 744
Query: 226 QN--LIWSSSPPRC 237
W+S PP C
Sbjct: 745 PGHPSQWTSQPPLC 758
Score = 33.5 bits (75), Expect = 0.22
Identities = 21/66 (31%), Positives = 33/66 (50%), Gaps = 6/66 (9%)
Query: 180 CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNL--IWSSSPPRC 237
C P ++G V++++L P GT ++ C G++L G L CL W+ P C
Sbjct: 220 CGFPPRPAHGDVSVTDLH---PGGTA-TFHCDSGYQLQGEETLICLNGTRPSWNGETPSC 275
Query: 238 LALEGG 243
+A GG
Sbjct: 276 MASCGG 281
Score = 30.0 bits (66), Expect = 2.5
Identities = 13/29 (44%), Positives = 17/29 (58%), Gaps = 3/29 (10%)
Query: 78 GSVARFHCQDGFKLKGATKRLCLKHFNGT 106
G A FHC G++L+G +CL NGT
Sbjct: 239 GGTATFHCDSGYQLQGEETLICL---NGT 264
Score = 28.9 bits (63), Expect = 5.5
Identities = 14/57 (24%), Positives = 27/57 (47%), Gaps = 5/57 (8%)
Query: 192 NISELQTSFPVGTVISYRCFPGFKLDGSA---YLECLQ--NLIWSSSPPRCLALEGG 243
N++ + G + ++ C PG+ L+ +EC+ W+ + P C A+ GG
Sbjct: 403 NVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGG 459
>gi|166235136 seizure related 6 homolog (mouse)-like 2 isoform 2
[Homo sapiens]
Length = 910
Score = 65.9 bits (159), Expect = 4e-11
Identities = 47/161 (29%), Positives = 76/161 (47%), Gaps = 24/161 (14%)
Query: 125 PQIEDAEIHNKTYRHGEKL---IIT--CHEGFKIRYPDLHNMVSLCRDDGTWNNLP-ICQ 178
P++ E +T HG+ + ++T C G+++ D + C+ D +W+ P CQ
Sbjct: 645 PELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSD----ILTCQWDLSWSAAPPACQ 700
Query: 179 G---CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLI----WS 231
C P +NG+ S+ FPVG+ + YRC PG+ L+G+A L C WS
Sbjct: 701 KIMTCADPGEIANGHRTASD--AGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWS 758
Query: 232 SSPPRCL-----ALEGGRPEHLFPVLYFPHIRLAAAVLYFC 267
P+C L G PE+ + LY H + ++ +FC
Sbjct: 759 DRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFC 799
Score = 56.6 bits (135), Expect = 2e-08
Identities = 33/104 (31%), Positives = 48/104 (46%), Gaps = 4/104 (3%)
Query: 54 LQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSD 113
+ CADPG NG RT S F GS ++ C G+ L+GA C GT W
Sbjct: 702 IMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRV 761
Query: 114 NSICVQ-EDCRIPQIED---AEIHNKTYRHGEKLIITCHEGFKI 153
++ E C P + + ++ Y+ GE L C+EGF++
Sbjct: 762 PKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFEL 805
Score = 56.2 bits (134), Expect = 3e-08
Identities = 50/194 (25%), Positives = 80/194 (41%), Gaps = 22/194 (11%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C + PE G+RT S G G+V + C+ G++L G+ C L W + +
Sbjct: 644 CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTC----QWDLSWSAAPPAC 699
Query: 117 CVQEDCRIPQIEDAEIHNKT----YRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGT-- 170
C P E A H + G + C G+ + + + RD GT
Sbjct: 700 QKIMTCADPG-EIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAM--LTCYSRDTGTPK 756
Query: 171 WNN-LPIC----QGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECL 225
W++ +P C + CL P NGY + + + G + + C+ GF+L G + C+
Sbjct: 757 WSDRVPKCALKYEPCLNPGVPENGYQTL--YKHHYQAGESLRFFCYEGFELIGEVTITCV 814
Query: 226 QN--LIWSSSPPRC 237
W+S PP C
Sbjct: 815 PGHPSQWTSQPPLC 828
Score = 33.5 bits (75), Expect = 0.22
Identities = 21/66 (31%), Positives = 33/66 (50%), Gaps = 6/66 (9%)
Query: 180 CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNL--IWSSSPPRC 237
C P ++G V++++L P GT ++ C G++L G L CL W+ P C
Sbjct: 290 CGFPPRPAHGDVSVTDLH---PGGTA-TFHCDSGYQLQGEETLICLNGTRPSWNGETPSC 345
Query: 238 LALEGG 243
+A GG
Sbjct: 346 MASCGG 351
Score = 30.0 bits (66), Expect = 2.5
Identities = 13/29 (44%), Positives = 17/29 (58%), Gaps = 3/29 (10%)
Query: 78 GSVARFHCQDGFKLKGATKRLCLKHFNGT 106
G A FHC G++L+G +CL NGT
Sbjct: 309 GGTATFHCDSGYQLQGEETLICL---NGT 334
Score = 28.9 bits (63), Expect = 5.5
Identities = 14/57 (24%), Positives = 27/57 (47%), Gaps = 5/57 (8%)
Query: 192 NISELQTSFPVGTVISYRCFPGFKLDGSA---YLECLQ--NLIWSSSPPRCLALEGG 243
N++ + G + ++ C PG+ L+ +EC+ W+ + P C A+ GG
Sbjct: 473 NVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGG 529
>gi|6912612 seizure related 6 homolog (mouse)-like 2 isoform 1 [Homo
sapiens]
Length = 853
Score = 65.9 bits (159), Expect = 4e-11
Identities = 47/161 (29%), Positives = 76/161 (47%), Gaps = 24/161 (14%)
Query: 125 PQIEDAEIHNKTYRHGEKL---IIT--CHEGFKIRYPDLHNMVSLCRDDGTWNNLP-ICQ 178
P++ E +T HG+ + ++T C G+++ D + C+ D +W+ P CQ
Sbjct: 575 PELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSD----ILTCQWDLSWSAAPPACQ 630
Query: 179 G---CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLI----WS 231
C P +NG+ S+ FPVG+ + YRC PG+ L+G+A L C WS
Sbjct: 631 KIMTCADPGEIANGHRTASD--AGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWS 688
Query: 232 SSPPRCL-----ALEGGRPEHLFPVLYFPHIRLAAAVLYFC 267
P+C L G PE+ + LY H + ++ +FC
Sbjct: 689 DRVPKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFC 729
Score = 56.6 bits (135), Expect = 2e-08
Identities = 33/104 (31%), Positives = 48/104 (46%), Gaps = 4/104 (3%)
Query: 54 LQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSD 113
+ CADPG NG RT S F GS ++ C G+ L+GA C GT W
Sbjct: 632 IMTCADPGEIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRV 691
Query: 114 NSICVQ-EDCRIPQIED---AEIHNKTYRHGEKLIITCHEGFKI 153
++ E C P + + ++ Y+ GE L C+EGF++
Sbjct: 692 PKCALKYEPCLNPGVPENGYQTLYKHHYQAGESLRFFCYEGFEL 735
Score = 56.2 bits (134), Expect = 3e-08
Identities = 50/194 (25%), Positives = 80/194 (41%), Gaps = 22/194 (11%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C + PE G+RT S G G+V + C+ G++L G+ C L W + +
Sbjct: 574 CPELPPPEWGWRTASHGDLIRGTVLTYQCEPGYELLGSDILTC----QWDLSWSAAPPAC 629
Query: 117 CVQEDCRIPQIEDAEIHNKT----YRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGT-- 170
C P E A H + G + C G+ + + + RD GT
Sbjct: 630 QKIMTCADPG-EIANGHRTASDAGFPVGSHVQYRCLPGYSLEGAAM--LTCYSRDTGTPK 686
Query: 171 WNN-LPIC----QGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECL 225
W++ +P C + CL P NGY + + + G + + C+ GF+L G + C+
Sbjct: 687 WSDRVPKCALKYEPCLNPGVPENGYQTL--YKHHYQAGESLRFFCYEGFELIGEVTITCV 744
Query: 226 QN--LIWSSSPPRC 237
W+S PP C
Sbjct: 745 PGHPSQWTSQPPLC 758
Score = 33.5 bits (75), Expect = 0.22
Identities = 21/66 (31%), Positives = 33/66 (50%), Gaps = 6/66 (9%)
Query: 180 CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNL--IWSSSPPRC 237
C P ++G V++++L P GT ++ C G++L G L CL W+ P C
Sbjct: 220 CGFPPRPAHGDVSVTDLH---PGGTA-TFHCDSGYQLQGEETLICLNGTRPSWNGETPSC 275
Query: 238 LALEGG 243
+A GG
Sbjct: 276 MASCGG 281
Score = 30.0 bits (66), Expect = 2.5
Identities = 13/29 (44%), Positives = 17/29 (58%), Gaps = 3/29 (10%)
Query: 78 GSVARFHCQDGFKLKGATKRLCLKHFNGT 106
G A FHC G++L+G +CL NGT
Sbjct: 239 GGTATFHCDSGYQLQGEETLICL---NGT 264
Score = 28.9 bits (63), Expect = 5.5
Identities = 14/57 (24%), Positives = 27/57 (47%), Gaps = 5/57 (8%)
Query: 192 NISELQTSFPVGTVISYRCFPGFKLDGSA---YLECLQ--NLIWSSSPPRCLALEGG 243
N++ + G + ++ C PG+ L+ +EC+ W+ + P C A+ GG
Sbjct: 403 NVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGG 459
>gi|117320518 complement factor H-related 4 [Homo sapiens]
Length = 331
Score = 63.9 bits (154), Expect = 2e-10
Identities = 54/195 (27%), Positives = 91/195 (46%), Gaps = 23/195 (11%)
Query: 54 LQVCADPGIP-ENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKR---LCLKHFNGTLGW 109
L+ C+ I ENGF + S ++ ++ C+ G+ CL++ GW
Sbjct: 85 LRTCSKSDIEIENGFISESSSIYILNKEIQYKCKPGYATADGNSSGSITCLQN-----GW 139
Query: 110 IPSDNSICVQEDCRIPQIED--AEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRD 167
S IC+ + C +P E+ A+ + ++ + L C++G++I Y + + +C +
Sbjct: 140 --SAQPICI-KFCDMPVFENSRAKSNGMRFKLHDTLDYECYDGYEISYGNTTGSI-VCGE 195
Query: 168 DGTWNNLPIC----QGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLE 223
DG W++ P C + C P SNG L+ P V Y+C ++L GS Y+
Sbjct: 196 DG-WSHFPTCYNSSEKCGPPPPISNGDTTSFLLKVYVPQSRV-EYQCQSYYELQGSNYVT 253
Query: 224 CLQNLIWSSSPPRCL 238
C N W S PPRC+
Sbjct: 254 C-SNGEW-SEPPRCI 266
>gi|62739188 complement factor H isoform b precursor [Homo sapiens]
Length = 449
Score = 62.4 bits (150), Expect = 5e-10
Identities = 45/183 (24%), Positives = 79/183 (43%), Gaps = 25/183 (13%)
Query: 77 EGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDN-SICVQEDCRIPQIEDAEIHNK 135
EG+ A + C+ G++ G +C K W+ + C + C P
Sbjct: 44 EGTQAIYKCRPGYRSLGNVIMVCRKG-----EWVALNPLRKCQKRPCGHPGDTPFGTFTL 98
Query: 136 T----YRHGEKLIITCHEGFK----IRYPDLHNMVSLCRDDGTWNNLPICQ--GCLRPLA 185
T + +G K + TC+EG++ I Y + C DG N++PIC+ CL A
Sbjct: 99 TGGNVFEYGVKAVYTCNEGYQLLGEINYRE-------CDTDGWTNDIPICEVVKCLPVTA 151
Query: 186 SSNGYVNISELQTS--FPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLALEGG 243
NG + S ++ + G + + C G+K++G + C + WS P+C+ +
Sbjct: 152 PENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCK 211
Query: 244 RPE 246
P+
Sbjct: 212 SPD 214
Score = 30.4 bits (67), Expect = 1.9
Identities = 19/72 (26%), Positives = 37/72 (51%), Gaps = 9/72 (12%)
Query: 108 GWIPSDNSICVQEDCRIPQIEDA--EIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLC 165
GW P+ C+++ C P +E+ + H + + G+ + + CH G+ + P V+ C
Sbjct: 378 GWSPAVP--CLRK-CYFPYLENGYNQNHGRKFVQGKSIDVACHPGYAL--PKAQTTVT-C 431
Query: 166 RDDGTWNNLPIC 177
++G W+ P C
Sbjct: 432 MENG-WSPTPRC 442
>gi|4502503 complement component 4 binding protein, alpha chain
precursor [Homo sapiens]
Length = 597
Score = 62.0 bits (149), Expect = 6e-10
Identities = 53/188 (28%), Positives = 80/188 (42%), Gaps = 20/188 (10%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLG-WIPSDNS 115
C P NG + + G + C F L G C N T+G W PS +
Sbjct: 175 CKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVE-NETIGVWRPSPPT 233
Query: 116 ICVQEDCRIPQIEDAEI---HNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWN 172
C + CR P + E+ Y + + ++ C +GF +R + V C D WN
Sbjct: 234 -CEKITCRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLR----GSSVIHCDADSKWN 288
Query: 173 -NLPICQ--GCLR----PLASSNGYVNISELQTSFPVGTVISYRCFPGFK--LDGSAYLE 223
+ P C+ C+ P AS Y ++ + + VGTV+ YRC PG+K D +
Sbjct: 289 PSPPACEPNSCINLPDIPHASWETYPRPTK-EDVYVVGTVLRYRCHPGYKPTTDEPTTVI 347
Query: 224 CLQNLIWS 231
C +NL W+
Sbjct: 348 CQKNLRWT 355
Score = 60.1 bits (144), Expect = 2e-09
Identities = 56/198 (28%), Positives = 85/198 (42%), Gaps = 34/198 (17%)
Query: 60 PGIPENGFRT----PSGGVFFEGSVARFHCQDGFK--LKGATKRLCLKHFNGTLGWIPSD 113
P IP + T V+ G+V R+ C G+K T +C K+ L W P
Sbjct: 303 PDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKN----LRWTPYQ 358
Query: 114 NSICVQEDCRIPQIEDAEI--HNKT-------YRHGEKLIITCHEGFKIRYPDLHNMVSL 164
C C P++ + EI H K+ Y +G+++ +CHE + ++
Sbjct: 359 G--CEALCCPEPKLNNGEITQHRKSRPANHCVYFYGDEISFSCHETSRFS--------AI 408
Query: 165 CRDDGTWN-NLPICQG-CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYL 222
C+ DGTW+ P C C P ++G+ S + F I Y C G+ L G A L
Sbjct: 409 CQGDGTWSPRTPSCGDICNFPPKIAHGHYKQSSSYSFFK--EEIIYECDKGYILVGQAKL 466
Query: 223 ECLQNLIWSSSPPRCLAL 240
C + WS+ P+C AL
Sbjct: 467 SCSYS-HWSAPAPQCKAL 483
Score = 51.6 bits (122), Expect = 8e-07
Identities = 49/184 (26%), Positives = 85/184 (46%), Gaps = 23/184 (12%)
Query: 75 FFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDCRIP-QIEDAEIH 133
F G+ ++ C G+ +T+ L N W+ N+ C+ + CR P ++ + ++
Sbjct: 71 FKTGTTLKYTCLPGYVRSHSTQTLTC---NSDGEWVY--NTFCIYKRCRHPGELRNGQVE 125
Query: 134 NKT-YRHGEKLIITCHEGFKIRYPDLHNMVSLC--RDDGT-WNN-LPICQ--GCLRPLAS 186
KT G ++ +C EGF + + + S C +D G W++ LP C+ C P
Sbjct: 126 IKTDLSFGSQIEFSCSEGFFL----IGSTTSRCEVQDRGVGWSHPLPQCEIVKCKPPPDI 181
Query: 187 SNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLEC-LQNL---IWSSSPPRCLALEG 242
NG S + + G ++Y C P F L G A + C ++N +W SPP C +
Sbjct: 182 RNG--RHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSPPTCEKITC 239
Query: 243 GRPE 246
+P+
Sbjct: 240 RKPD 243
Score = 46.6 bits (109), Expect = 3e-05
Identities = 52/193 (26%), Positives = 76/193 (39%), Gaps = 23/193 (11%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGW---IPSD 113
C PG NG + F GS F C +GF L G+T C G +GW +P
Sbjct: 113 CRHPGELRNGQVEIKTDLSF-GSQIEFSCSEGFFLIGSTTSRCEVQDRG-VGWSHPLPQ- 169
Query: 114 NSICVQEDCRIPQIEDAEIHN---KTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDD-- 168
C C+ P H+ Y +G + +C F + H +S ++
Sbjct: 170 ---CEIVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLG---HASISCTVENET 223
Query: 169 -GTWN-NLPICQG--CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLEC 224
G W + P C+ C +P S V S + I ++C GF L GS+ + C
Sbjct: 224 IGVWRPSPPTCEKITCRKPDVSHGEMV--SGFGPIYNYKDTIVFKCQKGFVLRGSSVIHC 281
Query: 225 LQNLIWSSSPPRC 237
+ W+ SPP C
Sbjct: 282 DADSKWNPSPPAC 294
>gi|42544177 complement component (3d/Epstein Barr virus) receptor 2
isoform 2 [Homo sapiens]
Length = 1033
Score = 61.6 bits (148), Expect = 8e-10
Identities = 57/204 (27%), Positives = 76/204 (37%), Gaps = 22/204 (10%)
Query: 57 CADPGIPENGFRTPSGGV-FFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWI-PSDN 114
C P + NG T F G+ + C GF L G K C G W PS
Sbjct: 719 CHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQ 778
Query: 115 SICVQED----CRIPQIEDAEIHNKT---YRHGEKLIITCHEGFKIRYPDLHNMVSLCRD 167
C++ C P+++ NKT Y H + + + C+ GF + + V C
Sbjct: 779 --CLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMN----GSRVIRCHT 832
Query: 168 DGTW-NNLPICQ-----GCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAY 221
D TW +P C GC P + NG + F G I Y C G+ L G A
Sbjct: 833 DNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNI-ARFSPGMSILYSCDQGYLLVGEAL 891
Query: 222 LECLQNLIWSSSPPRCLALEGGRP 245
L C WS P C + P
Sbjct: 892 LLCTHEGTWSQPAPHCKEVNCSSP 915
Score = 55.1 bits (131), Expect = 7e-08
Identities = 56/207 (27%), Positives = 79/207 (38%), Gaps = 25/207 (12%)
Query: 78 GSVARFHCQDGFKLKGATKRLCLKHFNGTLGW---IPSDNSICVQEDCRIPQIEDA-EIH 133
G+V R+ C F+L G LC+ W P C P + +I
Sbjct: 44 GTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYFNKYSSCPEPIVPGGYKIR 103
Query: 134 NKT-YRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWN--NLPICQG-----CLRPLA 185
T YRHG+ + C F + N C+ + W LP C C
Sbjct: 104 GSTPYRHGDSVTFACKTNFSMN----GNKSVWCQANNMWGPTRLPTCVSVFPLECPALPM 159
Query: 186 SSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLALEGGRP 245
NG+ + SE S G ++Y C G+ L G + CL + WS+ PP C E R
Sbjct: 160 IHNGH-HTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPTC---EEARC 215
Query: 246 EHL--FP---VLYFPHIRLAAAVLYFC 267
+ L FP V P +R+ +FC
Sbjct: 216 KSLGRFPNGKVKEPPILRVGVTANFFC 242
Score = 53.5 bits (127), Expect = 2e-07
Identities = 41/169 (24%), Positives = 72/169 (42%), Gaps = 22/169 (13%)
Query: 85 CQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDCRIPQIEDAEIHN----KTYRHG 140
C +G+KL G+ + C GT+ W + +C + C P + H + + +G
Sbjct: 495 CGEGYKLSGSVYQEC----QGTIPWF-MEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYG 549
Query: 141 EKLIITCHEG------FKIRYPDLHNMVSLCRDDGTWNN-LPICQGCLRPLASS-----N 188
+ TC+ G F + S ++ GTW+ P+C+ L + S N
Sbjct: 550 TTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIAN 609
Query: 189 GYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRC 237
GY IS + + ++++C+ GF L GS+ + C + W P C
Sbjct: 610 GY-KISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVC 657
Score = 50.8 bits (120), Expect = 1e-06
Identities = 43/173 (24%), Positives = 73/173 (42%), Gaps = 21/173 (12%)
Query: 75 FFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDCRIPQIEDAEIHN 134
+F F C GF LKG+++ C W P + +C +E C+ + +
Sbjct: 620 YFYNDTVTFKCYSGFTLKGSSQIRC----KADNTWDP-EIPVCEKETCQ--HVRQSLQEL 672
Query: 135 KTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRD--DGTW-NNLPICQ--GCLRPLASSNG 189
E + +C +G+++ + +C+D +G W +P+C+ C P NG
Sbjct: 673 PAGSRVELVNTSCQDGYQL----TGHAYQMCQDAENGIWFKKIPLCKVIHCHPPPVIVNG 728
Query: 190 YVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNL----IWSSSPPRCL 238
+ + +F G +SY C GF L G L+C + WS P+CL
Sbjct: 729 -KHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCL 780
Score = 48.5 bits (114), Expect = 7e-06
Identities = 29/103 (28%), Positives = 45/103 (43%), Gaps = 7/103 (6%)
Query: 137 YRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWN-NLPICQG-CLRPLASSNGYVNIS 194
Y + + +I C GF ++ + C GTW + P+C+ C P NG
Sbjct: 369 YTYNDTVIFACMFGFTLK----GSKQIRCNAQGTWEPSAPVCEKECQAPPNILNGQKEDR 424
Query: 195 ELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRC 237
+ F GT I Y C PG+ L G ++C +W+ P+C
Sbjct: 425 HM-VRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQC 466
Score = 46.6 bits (109), Expect = 3e-05
Identities = 45/205 (21%), Positives = 79/205 (38%), Gaps = 24/205 (11%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C +P + + + + C GF + G+ C H + T W+P +
Sbjct: 788 CPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRC--HTDNT--WVPGVPTC 843
Query: 117 CVQEDCRIPQIEDAEIHNKT------YRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGT 170
+ P N T + G ++ +C +G+ + + + LC +GT
Sbjct: 844 IKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLL----VGEALLLCTHEGT 899
Query: 171 WNN-LPICQ--GCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQN 227
W+ P C+ C P A +G E + + G V++ C G+ L+GS +C +
Sbjct: 900 WSQPAPHCKEVNCSSP-ADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSD 958
Query: 228 LIWSSSPPRCLALEGGRPEHLFPVL 252
W +PP + R L PVL
Sbjct: 959 HQW--NPPLAVC----RSRSLAPVL 977
Score = 45.1 bits (105), Expect = 7e-05
Identities = 46/177 (25%), Positives = 71/177 (40%), Gaps = 25/177 (14%)
Query: 83 FHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDCRIP------QIEDAEIHNKT 136
F C GF LKG+ + C N W PS +C +++C+ P Q ED H
Sbjct: 377 FACMFGFTLKGSKQIRC----NAQGTWEPSA-PVC-EKECQAPPNILNGQKEDR--HMVR 428
Query: 137 YRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNLPICQGCLRPLASSNGYVNISEL 196
+ G + +C+ G+ + + C +G W P C + G +++
Sbjct: 429 FDPGTSIKYSCNPGYVL----VGEESIQCTSEGVWT--PPVPQCKVAACEATGRQLLTKP 482
Query: 197 QTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLALEGGRPEHLFPVLY 253
Q F V ++ C G+KL GS Y EC + W C + P PV+Y
Sbjct: 483 QHQF-VRPDVNSSCGEGYKLSGSVYQECQGTIPWFMEIRLCKEITCPPP----PVIY 534
Score = 35.4 bits (80), Expect = 0.059
Identities = 39/177 (22%), Positives = 65/177 (36%), Gaps = 22/177 (12%)
Query: 78 GSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDCRIPQ--IEDAEIHNK 135
G A F C +G++L+G C+ G + W + +C + C P + I N
Sbjct: 235 GVTANFFCDEGYRLQGPPSSRCVIAGQG-VAW--TKMPVCEEIFCPSPPPILNGRHIGNS 291
Query: 136 --TYRHGEKLIITC----HEGFKIRYPDLHNMVSLCRDD----GTWNN-LPICQGCLRPL 184
+G + TC EG + + + C D GTW+ P C+ +
Sbjct: 292 LANVSYGSIVTYTCDPDPEEG--VNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAV 349
Query: 185 ASSNGYV----NISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRC 237
+ + +S + + + + C GF L GS + C W S P C
Sbjct: 350 QCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVC 406
Score = 32.3 bits (72), Expect = 0.50
Identities = 22/62 (35%), Positives = 26/62 (41%), Gaps = 6/62 (9%)
Query: 180 CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQ----NLIWSSSPP 235
C P NG IS T VGTVI Y C F+L G L C+ + W P
Sbjct: 23 CGSPPPILNG--RISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAP 80
Query: 236 RC 237
+C
Sbjct: 81 KC 82
>gi|54792123 complement component (3d/Epstein Barr virus) receptor 2
isoform 1 [Homo sapiens]
Length = 1092
Score = 61.6 bits (148), Expect = 8e-10
Identities = 57/204 (27%), Positives = 76/204 (37%), Gaps = 22/204 (10%)
Query: 57 CADPGIPENGFRTPSGGV-FFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWI-PSDN 114
C P + NG T F G+ + C GF L G K C G W PS
Sbjct: 778 CHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQ 837
Query: 115 SICVQED----CRIPQIEDAEIHNKT---YRHGEKLIITCHEGFKIRYPDLHNMVSLCRD 167
C++ C P+++ NKT Y H + + + C+ GF + + V C
Sbjct: 838 --CLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMN----GSRVIRCHT 891
Query: 168 DGTW-NNLPICQ-----GCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAY 221
D TW +P C GC P + NG + F G I Y C G+ L G A
Sbjct: 892 DNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNI-ARFSPGMSILYSCDQGYLLVGEAL 950
Query: 222 LECLQNLIWSSSPPRCLALEGGRP 245
L C WS P C + P
Sbjct: 951 LLCTHEGTWSQPAPHCKEVNCSSP 974
Score = 55.1 bits (131), Expect = 7e-08
Identities = 56/207 (27%), Positives = 79/207 (38%), Gaps = 25/207 (12%)
Query: 78 GSVARFHCQDGFKLKGATKRLCLKHFNGTLGW---IPSDNSICVQEDCRIPQIEDA-EIH 133
G+V R+ C F+L G LC+ W P C P + +I
Sbjct: 44 GTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYFNKYSSCPEPIVPGGYKIR 103
Query: 134 NKT-YRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWN--NLPICQG-----CLRPLA 185
T YRHG+ + C F + N C+ + W LP C C
Sbjct: 104 GSTPYRHGDSVTFACKTNFSMN----GNKSVWCQANNMWGPTRLPTCVSVFPLECPALPM 159
Query: 186 SSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLALEGGRP 245
NG+ + SE S G ++Y C G+ L G + CL + WS+ PP C E R
Sbjct: 160 IHNGH-HTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPTC---EEARC 215
Query: 246 EHL--FP---VLYFPHIRLAAAVLYFC 267
+ L FP V P +R+ +FC
Sbjct: 216 KSLGRFPNGKVKEPPILRVGVTANFFC 242
Score = 53.1 bits (126), Expect = 3e-07
Identities = 61/249 (24%), Positives = 97/249 (38%), Gaps = 38/249 (15%)
Query: 5 MNPSNGDGFLEQQQQQQQPQSPQRLLAVILWF-QLALCFGPAQLTGGFDDLQVCADPGIP 63
+N S G+G+ Q+ Q I WF ++ LC ++T C P +
Sbjct: 491 VNSSCGEGYKLSGSVYQECQG------TIPWFMEIRLC---KEIT--------CPPPPVI 533
Query: 64 ENGFRTPSGGVFFE-GSVARFHCQDG------FKLKGATKRLCLKHFNGTLGW---IPSD 113
NG T S F G+ + C G F L G + C + W P
Sbjct: 534 YNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLC 593
Query: 114 NSICVQEDCRIPQIEDA-EIHNKT--YRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGT 170
+ C I + +I K Y + + + C+ GF ++ + C+ D T
Sbjct: 594 KLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLK----GSSQIRCKADNT 649
Query: 171 WN-NLPICQ-GCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNL 228
W+ +P+C+ GC P +G + F G + Y C PG+ L G+ + C+ +
Sbjct: 650 WDPEIPVCEKGCQSPPGLHHGR-HTGGNTVFFVSGMTVDYTCDPGYLLVGNKSIHCMPSG 708
Query: 229 IWSSSPPRC 237
WS S PRC
Sbjct: 709 NWSPSAPRC 717
Score = 48.5 bits (114), Expect = 7e-06
Identities = 29/103 (28%), Positives = 45/103 (43%), Gaps = 7/103 (6%)
Query: 137 YRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWN-NLPICQG-CLRPLASSNGYVNIS 194
Y + + +I C GF ++ + C GTW + P+C+ C P NG
Sbjct: 369 YTYNDTVIFACMFGFTLK----GSKQIRCNAQGTWEPSAPVCEKECQAPPNILNGQKEDR 424
Query: 195 ELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRC 237
+ F GT I Y C PG+ L G ++C +W+ P+C
Sbjct: 425 HM-VRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQC 466
Score = 46.6 bits (109), Expect = 3e-05
Identities = 45/205 (21%), Positives = 79/205 (38%), Gaps = 24/205 (11%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C +P + + + + C GF + G+ C H + T W+P +
Sbjct: 847 CPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRC--HTDNT--WVPGVPTC 902
Query: 117 CVQEDCRIPQIEDAEIHNKT------YRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGT 170
+ P N T + G ++ +C +G+ + + + LC +GT
Sbjct: 903 IKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLL----VGEALLLCTHEGT 958
Query: 171 WNN-LPICQ--GCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQN 227
W+ P C+ C P A +G E + + G V++ C G+ L+GS +C +
Sbjct: 959 WSQPAPHCKEVNCSSP-ADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSD 1017
Query: 228 LIWSSSPPRCLALEGGRPEHLFPVL 252
W +PP + R L PVL
Sbjct: 1018 HQW--NPPLAVC----RSRSLAPVL 1036
Score = 45.8 bits (107), Expect = 4e-05
Identities = 38/169 (22%), Positives = 69/169 (40%), Gaps = 24/169 (14%)
Query: 85 CQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDCRIPQI----EDAEIHNKTYRHG 140
CQDG++L G ++C NG W +C C P + + + + + +G
Sbjct: 744 CQDGYQLTGHAYQMCQDAENGI--WF-KKIPLCKVIHCHPPPVIVNGKHTGMMAENFLYG 800
Query: 141 EKLIITCHEGFKIRYPDLHNMVSLCRDD----GTWN-------NLPICQGCLRPLASSNG 189
++ C +GF + L CR D G+W+ P C P +G
Sbjct: 801 NEVSYECDQGFYL----LGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNP-EVKHG 855
Query: 190 YVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCL 238
Y +++ +++ ++ C PGF ++GS + C + W P C+
Sbjct: 856 Y-KLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCI 903
Score = 35.4 bits (80), Expect = 0.059
Identities = 39/177 (22%), Positives = 65/177 (36%), Gaps = 22/177 (12%)
Query: 78 GSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDCRIPQ--IEDAEIHNK 135
G A F C +G++L+G C+ G + W + +C + C P + I N
Sbjct: 235 GVTANFFCDEGYRLQGPPSSRCVIAGQG-VAW--TKMPVCEEIFCPSPPPILNGRHIGNS 291
Query: 136 --TYRHGEKLIITC----HEGFKIRYPDLHNMVSLCRDD----GTWNN-LPICQGCLRPL 184
+G + TC EG + + + C D GTW+ P C+ +
Sbjct: 292 LANVSYGSIVTYTCDPDPEEG--VNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAV 349
Query: 185 ASSNGYV----NISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRC 237
+ + +S + + + + C GF L GS + C W S P C
Sbjct: 350 QCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVC 406
Score = 32.3 bits (72), Expect = 0.50
Identities = 22/62 (35%), Positives = 26/62 (41%), Gaps = 6/62 (9%)
Query: 180 CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQ----NLIWSSSPP 235
C P NG IS T VGTVI Y C F+L G L C+ + W P
Sbjct: 23 CGSPPPILNG--RISYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAP 80
Query: 236 RC 237
+C
Sbjct: 81 KC 82
>gi|187960042 selectin E precursor [Homo sapiens]
Length = 610
Score = 60.5 bits (145), Expect = 2e-09
Identities = 52/190 (27%), Positives = 75/190 (39%), Gaps = 21/190 (11%)
Query: 63 PENGFRT--PSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQE 120
P NGF + G F + F C++GF+L GA C N W ++ C
Sbjct: 248 PANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGN----W-DNEKPTCKAV 302
Query: 121 DCR-IPQIEDAEIHNKTYRHGEKLI-----ITCHEGFKIRYPDLHNMVSLCRDDGTWNN- 173
CR + Q ++ + GE TC EGF ++ P C G W
Sbjct: 303 TCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVE----CTTQGQWTQQ 358
Query: 174 LPICQG--CLRPLASSNGYVN-ISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIW 230
+P+C+ C GY+N + SF G+ + C GF L GS L+C W
Sbjct: 359 IPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEW 418
Query: 231 SSSPPRCLAL 240
+ P C A+
Sbjct: 419 DNEKPTCEAV 428
Score = 57.0 bits (136), Expect = 2e-08
Identities = 56/197 (28%), Positives = 77/197 (39%), Gaps = 28/197 (14%)
Query: 57 CADPGIPENGFRT---PSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSD 113
C PE G+ + G F GS F C+ GF LKG+ + C G G ++
Sbjct: 367 CTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQC-----GPTGEWDNE 421
Query: 114 NSICVQEDCR--------IPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSL- 164
C C + + + I TY+ +C EGF +LH L
Sbjct: 422 KPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYK--SSCAFSCEEGF-----ELHGSTQLE 474
Query: 165 CRDDGTWNN-LPICQGCLRPLASSNGYVNISELQTSFPV-GTVISYRCFPGFKLDGSAYL 222
C G W +P CQ + G +N+S + PV GTV + C G+ L+GSA
Sbjct: 475 CTSQGQWTEEVPSCQVVKCSSLAVPGKINMS--CSGEPVFGTVCKFACPEGWTLNGSAAR 532
Query: 223 ECLQNLIWSSSPPRCLA 239
C WS P C A
Sbjct: 533 TCGATGHWSGLLPTCEA 549
Score = 49.3 bits (116), Expect = 4e-06
Identities = 46/189 (24%), Positives = 72/189 (38%), Gaps = 24/189 (12%)
Query: 63 PENGF----RTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICV 118
P+NG +P+G F+ S F C++GF L+G + C T G +C
Sbjct: 310 PQNGSVRCSHSPAGEFTFKSS-CNFTCEEGFMLQGPAQVECT-----TQGQWTQQIPVCE 363
Query: 119 QEDCRIPQIEDAEIHN------KTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWN 172
C + N ++R+G +C +GF ++ + C G W+
Sbjct: 364 AFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLK----GSKRLQCGPTGEWD 419
Query: 173 N-LPICQG--CLRPLASSNGYVNISELQTS-FPVGTVISYRCFPGFKLDGSAYLECLQNL 228
N P C+ C G V + F + ++ C GF+L GS LEC
Sbjct: 420 NEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQG 479
Query: 229 IWSSSPPRC 237
W+ P C
Sbjct: 480 QWTEEVPSC 488
Score = 44.7 bits (104), Expect = 1e-04
Identities = 24/79 (30%), Positives = 37/79 (46%), Gaps = 3/79 (3%)
Query: 165 CRDDGTWNN-LPICQ--GCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAY 221
C G W+ +P C C +NG+V + SFP T ++ C GF+L G+
Sbjct: 224 CMSSGEWSAPIPACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQS 283
Query: 222 LECLQNLIWSSSPPRCLAL 240
L+C + W + P C A+
Sbjct: 284 LQCTSSGNWDNEKPTCKAV 302
Score = 40.0 bits (92), Expect = 0.002
Identities = 31/100 (31%), Positives = 40/100 (40%), Gaps = 10/100 (10%)
Query: 147 CHEGFKIRYPDLHNMVSL-CRDDGTWNN-LPICQG--CLRPLASSNGYVNISELQTS-FP 201
C EGF +L SL C G W+N P C+ C NG V S F
Sbjct: 272 CEEGF-----ELMGAQSLQCTSSGNWDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFT 326
Query: 202 VGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLALE 241
+ ++ C GF L G A +EC W+ P C A +
Sbjct: 327 FKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEAFQ 366
>gi|148922949 complement component (3b/4b) receptor 1-like [Homo
sapiens]
Length = 569
Score = 59.7 bits (143), Expect = 3e-09
Identities = 50/196 (25%), Positives = 71/196 (36%), Gaps = 15/196 (7%)
Query: 53 DLQVCADPGIPENG-FRTPSGGVFFEGSVARFHCQDG------FKLKGATKRLCLKHFNG 105
D +C P NG F + S F GSV +HC G F+L G C +
Sbjct: 154 DRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQ 213
Query: 106 TLGWIPSDNSICVQEDCRIPQIEDAEI---HNKTYRHGEKLIITCHEGFKIRYPDLHNMV 162
W + C P +E+ + + + E + C GF ++ P
Sbjct: 214 VGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGPSHVK-- 271
Query: 163 SLCRDDGTWN-NLPICQGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAY 221
C+ W LP C +P + +F G + Y C PG+ L GS Y
Sbjct: 272 --CQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTY 329
Query: 222 LECLQNLIWSSSPPRC 237
L C WS + PRC
Sbjct: 330 LHCTPQGDWSPAAPRC 345
Score = 55.1 bits (131), Expect = 7e-08
Identities = 46/171 (26%), Positives = 75/171 (43%), Gaps = 16/171 (9%)
Query: 75 FFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQE-DCRIPQIEDAEI- 132
F G + C+ G+ L+G+T C + W P+ V+ D + Q+ + +
Sbjct: 308 FSPGQEVFYSCEPGYDLRGSTYLHCTPQGD----WSPAAPRCEVKSCDDFLGQLPNGHVL 363
Query: 133 HNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNN-LPICQ--GCLRPLASSNG 189
+ G K+ C EGF+++ V L + WN+ +P+C+ C P NG
Sbjct: 364 FPLNLQLGAKVDFVCDEGFQLKGSSASYCV-LAGMESLWNSSVPVCERKSCETPPVPVNG 422
Query: 190 YVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECL---QNLIWSSSPPRC 237
V++ T VG+ I+Y C G +L G + EC+ WS PP C
Sbjct: 423 MVHVI---TDIHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPIC 470
Score = 50.1 bits (118), Expect = 2e-06
Identities = 43/198 (21%), Positives = 84/198 (42%), Gaps = 25/198 (12%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C +P P NG + F + ++ C G++L G++ C+ N T+ W + +
Sbjct: 96 CRNPPDPVNGMAHVIKDIQFRSQI-KYSCPKGYRLIGSSSATCIISGN-TVIW-DNKTPV 152
Query: 117 CVQEDCRIPQI----EDAEIHNKTYRHGEKLIITCHEGFK-------IRYPDLHNMVSLC 165
C + C +P + I + + +G + C+ G + + P ++
Sbjct: 153 CDRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIY---CTS 209
Query: 166 RDD--GTWNN-LPIC---QGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGS 219
+DD G W+ P C C P + + +S+ ++ F + V+ +RC PGF + G
Sbjct: 210 KDDQVGIWSGPAPQCIIPNKCTPPNVENG--ILVSDNRSLFSLNEVVEFRCQPGFGMKGP 267
Query: 220 AYLECLQNLIWSSSPPRC 237
++++C W P C
Sbjct: 268 SHVKCQALNKWEPELPSC 285
Score = 50.1 bits (118), Expect = 2e-06
Identities = 53/188 (28%), Positives = 79/188 (42%), Gaps = 24/188 (12%)
Query: 70 PSGGVFFE-----GSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDCRI 124
P+G V F G+ F C +GF+LKG++ C+ G S +C ++ C
Sbjct: 358 PNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCV--LAGMESLWNSSVPVCERKSCET 415
Query: 125 PQIE-DAEIHNKTYRH-GEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWN-NLPICQG-- 179
P + + +H T H G ++ +C G ++ + L + W+ PICQ
Sbjct: 416 PPVPVNGMVHVITDIHVGSRINYSCTTGHRLIGHSSAECI-LSGNTAHWSMKPPICQQIF 474
Query: 180 CLRPLASSNGYVNISELQTSFPVGTVISYRCFPG------FKLDGSAYL----ECLQNLI 229
C P A NG + L P G +SY C P F L G + + E N +
Sbjct: 475 CPNPPAILNGRHTGTPLG-DIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPHGNGV 533
Query: 230 WSSSPPRC 237
WSS PRC
Sbjct: 534 WSSPAPRC 541
Score = 39.7 bits (91), Expect = 0.003
Identities = 23/74 (31%), Positives = 37/74 (50%), Gaps = 9/74 (12%)
Query: 200 FPVGTVISYRCFPGFKLDGSAY-LECLQNLIWSSSPPRCLALEGGRPEHLFPVLYFPH-- 256
FP+GT ++Y C PG+ G + + CL+N +W+S+ +C P PV H
Sbjct: 55 FPIGTYLNYECRPGY--SGRPFSIICLKNSVWTSAKDKCKRKSCRNPPD--PVNGMAHVI 110
Query: 257 --IRLAAAVLYFCP 268
I+ + + Y CP
Sbjct: 111 KDIQFRSQIKYSCP 124
Score = 30.0 bits (66), Expect = 2.5
Identities = 22/97 (22%), Positives = 38/97 (39%), Gaps = 10/97 (10%)
Query: 178 QGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECL---QNLIWSSSP 234
+ C P NG ++ + + I Y C G++L GS+ C+ +IW +
Sbjct: 94 KSCRNPPDPVNGMAHVIK---DIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKT 150
Query: 235 PRCLALEGGRPEHL----FPVLYFPHIRLAAAVLYFC 267
P C + G P + F + + + V Y C
Sbjct: 151 PVCDRIICGLPPTIANGDFTSISREYFHYGSVVTYHC 187
>gi|86793109 complement receptor 1 isoform S precursor [Homo sapiens]
Length = 2489
Score = 57.4 bits (137), Expect = 1e-08
Identities = 51/203 (25%), Positives = 84/203 (41%), Gaps = 30/203 (14%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C P + + + +F V F CQ GF +KG + C + N +PS + +
Sbjct: 1588 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKC-QALNKWEPELPSCSRV 1646
Query: 117 CVQEDCRIPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSL-CRDDGTWN-NL 174
C Q I E H + G+++ +C G+ DL SL C G W+
Sbjct: 1647 C-QPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGY-----DLRGAASLHCTPQGDWSPEA 1700
Query: 175 PICQGCLRPLASSNGYV-NISELQTSFP----VGTVISYRCFPGFKLDGSAYLECL---Q 226
P C + S + ++ + + FP +G +S+ C GF+L GS+ C+
Sbjct: 1701 PRC-----AVKSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGM 1755
Query: 227 NLIWSSSPPRCLALEGGRPEHLF 249
+W++S P C EH+F
Sbjct: 1756 RSLWNNSVPVC--------EHIF 1770
Score = 53.5 bits (127), Expect = 2e-07
Identities = 55/227 (24%), Positives = 82/227 (36%), Gaps = 29/227 (12%)
Query: 60 PGIPENGFRTPSGGVFFEGSVARFHCQDG------FKLKGATKRLCLKHFNGTLGWIPSD 113
P I F + + F GSV + C G F+L G C + + W
Sbjct: 1520 PTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPA 1579
Query: 114 NSICVQEDCRIPQIEDAEI---HNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGT 170
+ C P +E+ + + + E + C GF ++ P C+
Sbjct: 1580 PQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVK----CQALNK 1635
Query: 171 WN-NLPICQGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLI 229
W LP C +P + Q +F G + Y C PG+ L G+A L C
Sbjct: 1636 WEPELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGD 1695
Query: 230 WSSSPPRCLA---------LEGGRPEHLFPVLYFPHIRLAAAVLYFC 267
WS PRC L GR LFP+ +++L A V + C
Sbjct: 1696 WSPEAPRCAVKSCDDFLGQLPHGRV--LFPL----NLQLGAKVSFVC 1736
Score = 53.5 bits (127), Expect = 2e-07
Identities = 55/211 (26%), Positives = 81/211 (38%), Gaps = 29/211 (13%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C P P NG + F GS + C +GF+L G+ CL N W I
Sbjct: 1907 CGPPPEPFNGMVHINTDTQF-GSTVNYSCNEGFRLIGSPSTTCLVSGNNVT-W-DKKAPI 1963
Query: 117 CVQEDCRIPQI---EDAEIHNKT-YRHGEKLIITCHEGFKIRYPDLHNMVSLC------- 165
C C P D +N+T + +G + CH G PD + L
Sbjct: 1964 CEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTG-----PDGEQLFELVGERSIYC 2018
Query: 166 --RDD--GTWNNLP----ICQGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLD 217
+DD G W++ P C P + + + ++ F + +I +RC PGF +
Sbjct: 2019 TSKDDQVGVWSSPPPRCISTNKCTAPEVENA--IRVPGNRSFFTLTEIIRFRCQPGFVMV 2076
Query: 218 GSAYLECLQNLIWSSSPPRCLALEGGRPEHL 248
GS ++C N W P C + PE L
Sbjct: 2077 GSHTVQCQTNGRWGPKLPHCSRVCQPPPEIL 2107
Score = 53.1 bits (126), Expect = 3e-07
Identities = 60/209 (28%), Positives = 88/209 (42%), Gaps = 39/209 (18%)
Query: 70 PSGGVFFE-----GSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQED--C 122
P G V F G+ F C +GF+LKG++ C+ +L W +NS+ V E C
Sbjct: 1716 PHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSL-W---NNSVPVCEHIFC 1771
Query: 123 RIPQIEDAEIHNKT----YRHGEKLIITC--HEGFKIRYPDLHNMVSLCRDD----GTWN 172
P H T +G+++ TC H + + + C D G W+
Sbjct: 1772 PNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWS 1831
Query: 173 N-LPICQGCLR----------PLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAY 221
+ P C+ +R P AS +N E FPVGT ++Y C PG+ G +
Sbjct: 1832 SPAPRCELSVRAGHCKTPEQFPFASPTIPINDFE----FPVGTSLNYECRPGYF--GKMF 1885
Query: 222 -LECLQNLIWSSSPPRCLALEGGRPEHLF 249
+ CL+NL+WSS C G P F
Sbjct: 1886 SISCLENLVWSSVEDNCRRKSCGPPPEPF 1914
Score = 53.1 bits (126), Expect = 3e-07
Identities = 49/193 (25%), Positives = 72/193 (37%), Gaps = 17/193 (8%)
Query: 57 CADPGIPENG-FRTPSGGVFFEGSVARFHCQDG------FKLKGATKRLCLKHFNGTLGW 109
C P NG F + + F G+V + C G F+L G C + W
Sbjct: 1969 CEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVW 2028
Query: 110 IPSDNSICVQEDCRIPQIEDA---EIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCR 166
C P++E+A + + E + C GF + + + C+
Sbjct: 2029 SSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVM----VGSHTVQCQ 2084
Query: 167 DDGTWN-NLPICQG-CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLEC 224
+G W LP C C P +G +S Q +F G + Y C P + L G+A L C
Sbjct: 2085 TNGRWGPKLPHCSRVCQPPPEILHGEHTLSH-QDNFSPGQEVFYSCEPSYDLRGAASLHC 2143
Query: 225 LQNLIWSSSPPRC 237
WS PRC
Sbjct: 2144 TPQGDWSPEAPRC 2156
Score = 52.8 bits (125), Expect = 4e-07
Identities = 46/191 (24%), Positives = 80/191 (41%), Gaps = 22/191 (11%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C P + + + +F V F CQ GF +KG + C + N +PS + +
Sbjct: 238 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKC-QALNKWEPELPSCSRV 296
Query: 117 CVQEDCRIPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSL-CRDDGTWN-NL 174
C Q + E + + G+++ +C G+ DL S+ C G W+
Sbjct: 297 C-QPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGY-----DLRGAASMRCTPQGDWSPAA 350
Query: 175 PICQGCLRPLASSNGYV-NISELQTSFPV----GTVISYRCFPGFKLDGSAYLECL---Q 226
P C+ + S + ++ + + FPV G + + C GF+L GS+ C+
Sbjct: 351 PTCE-----VKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGM 405
Query: 227 NLIWSSSPPRC 237
+W+SS P C
Sbjct: 406 ESLWNSSVPVC 416
Score = 52.8 bits (125), Expect = 4e-07
Identities = 46/191 (24%), Positives = 80/191 (41%), Gaps = 22/191 (11%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C P + + + +F V F CQ GF +KG + C + N +PS + +
Sbjct: 688 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKC-QALNKWEPELPSCSRV 746
Query: 117 CVQEDCRIPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSL-CRDDGTWN-NL 174
C Q + E + + G+++ +C G+ DL S+ C G W+
Sbjct: 747 C-QPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGY-----DLRGAASMRCTPQGDWSPAA 800
Query: 175 PICQGCLRPLASSNGYV-NISELQTSFPV----GTVISYRCFPGFKLDGSAYLECL---Q 226
P C+ + S + ++ + + FPV G + + C GF+L GS+ C+
Sbjct: 801 PTCE-----VKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGM 855
Query: 227 NLIWSSSPPRC 237
+W+SS P C
Sbjct: 856 ESLWNSSVPVC 866
Score = 52.8 bits (125), Expect = 4e-07
Identities = 46/191 (24%), Positives = 80/191 (41%), Gaps = 22/191 (11%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C P + + + +F V F CQ GF +KG + C + N +PS + +
Sbjct: 1138 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKC-QALNKWEPELPSCSRV 1196
Query: 117 CVQEDCRIPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSL-CRDDGTWN-NL 174
C Q + E + + G+++ +C G+ DL S+ C G W+
Sbjct: 1197 C-QPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGY-----DLRGAASMRCTPQGDWSPAA 1250
Query: 175 PICQGCLRPLASSNGYV-NISELQTSFPV----GTVISYRCFPGFKLDGSAYLECL---Q 226
P C+ + S + ++ + + FPV G + + C GF+L GS+ C+
Sbjct: 1251 PTCE-----VKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGM 1305
Query: 227 NLIWSSSPPRC 237
+W+SS P C
Sbjct: 1306 ESLWNSSVPVC 1316
Score = 50.4 bits (119), Expect = 2e-06
Identities = 49/214 (22%), Positives = 88/214 (41%), Gaps = 21/214 (9%)
Query: 40 LCFGPAQLTGGFDDLQ--VCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKR 97
+C + TG D + C +P P NG G+ F GS ++ C G++L G++
Sbjct: 85 ICLKNSVWTGAKDRCRRKSCRNPPDPVNGMVHVIKGIQF-GSQIKYSCTKGYRLIGSSSA 143
Query: 98 LCLKHFNGTLGWIPSDNSICVQEDCRIPQI----EDAEIHNKTYRHGEKLIITCHEGFKI 153
C+ T+ W ++ IC + C +P + + + + +G + C+ G
Sbjct: 144 TCIIS-GDTVIW-DNETPICDRIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGG 201
Query: 154 R----YPDLHNMVSLCRDD--GTWNN-LPIC---QGCLRPLASSNGYVNISELQTSFPVG 203
R ++ DD G W+ P C C P + + +S+ ++ F +
Sbjct: 202 RKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENG--ILVSDNRSLFSLN 259
Query: 204 TVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRC 237
V+ +RC PGF + G ++C W P C
Sbjct: 260 EVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSC 293
Score = 50.1 bits (118), Expect = 2e-06
Identities = 53/227 (23%), Positives = 81/227 (35%), Gaps = 29/227 (12%)
Query: 60 PGIPENGFRTPSGGVFFEGSVARFHCQDG------FKLKGATKRLCLKHFNGTLGWIPSD 113
P I F + + F GSV + C G F+L G C + + W
Sbjct: 170 PTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPA 229
Query: 114 NSICVQEDCRIPQIEDAEI---HNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGT 170
+ C P +E+ + + + E + C GF ++ P C+
Sbjct: 230 PQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVK----CQALNK 285
Query: 171 WN-NLPICQGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLI 229
W LP C +P + +F G + Y C PG+ L G+A + C
Sbjct: 286 WEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGD 345
Query: 230 WSSSPPRCLA---------LEGGRPEHLFPVLYFPHIRLAAAVLYFC 267
WS + P C L GR LFPV +++L A V + C
Sbjct: 346 WSPAAPTCEVKSCDDFMGQLLNGRV--LFPV----NLQLGAKVDFVC 386
Score = 50.1 bits (118), Expect = 2e-06
Identities = 53/227 (23%), Positives = 81/227 (35%), Gaps = 29/227 (12%)
Query: 60 PGIPENGFRTPSGGVFFEGSVARFHCQDG------FKLKGATKRLCLKHFNGTLGWIPSD 113
P I F + + F GSV + C G F+L G C + + W
Sbjct: 620 PTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPA 679
Query: 114 NSICVQEDCRIPQIEDAEI---HNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGT 170
+ C P +E+ + + + E + C GF ++ P C+
Sbjct: 680 PQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVK----CQALNK 735
Query: 171 WN-NLPICQGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLI 229
W LP C +P + +F G + Y C PG+ L G+A + C
Sbjct: 736 WEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGD 795
Query: 230 WSSSPPRCLA---------LEGGRPEHLFPVLYFPHIRLAAAVLYFC 267
WS + P C L GR LFPV +++L A V + C
Sbjct: 796 WSPAAPTCEVKSCDDFMGQLLNGRV--LFPV----NLQLGAKVDFVC 836
Score = 50.1 bits (118), Expect = 2e-06
Identities = 53/227 (23%), Positives = 81/227 (35%), Gaps = 29/227 (12%)
Query: 60 PGIPENGFRTPSGGVFFEGSVARFHCQDG------FKLKGATKRLCLKHFNGTLGWIPSD 113
P I F + + F GSV + C G F+L G C + + W
Sbjct: 1070 PTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPA 1129
Query: 114 NSICVQEDCRIPQIEDAEI---HNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGT 170
+ C P +E+ + + + E + C GF ++ P C+
Sbjct: 1130 PQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVK----CQALNK 1185
Query: 171 WN-NLPICQGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLI 229
W LP C +P + +F G + Y C PG+ L G+A + C
Sbjct: 1186 WEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGD 1245
Query: 230 WSSSPPRCLA---------LEGGRPEHLFPVLYFPHIRLAAAVLYFC 267
WS + P C L GR LFPV +++L A V + C
Sbjct: 1246 WSPAAPTCEVKSCDDFMGQLLNGRV--LFPV----NLQLGAKVDFVC 1286
Score = 46.6 bits (109), Expect = 3e-05
Identities = 46/177 (25%), Positives = 75/177 (42%), Gaps = 23/177 (12%)
Query: 78 GSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDCRIPQIEDAEIHN--- 134
G+ F C +GF+LKG++ C+ G S +C Q C P + H
Sbjct: 379 GAKVDFVCDEGFQLKGSSASYCV--LAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKP 436
Query: 135 -KTYRHGEKLIITC--HEGFKIRYPDLHNMVSLCRDD----GTWNN-LPICQGCLRPLAS 186
+ + G+ + TC H + + C D G W++ P C G L +
Sbjct: 437 LEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRC-GILGHCQA 495
Query: 187 SNGYVNISELQTS-----FPVGTVISYRCFPGFKLDGSAY-LECLQNLIWSSSPPRC 237
+ ++ ++L+T FP+GT + Y C P + G + + CL NL+WSS C
Sbjct: 496 PDHFL-FAKLKTQTNASDFPIGTSLKYECRPEYY--GRPFSITCLDNLVWSSPKDVC 549
Score = 46.6 bits (109), Expect = 3e-05
Identities = 46/177 (25%), Positives = 75/177 (42%), Gaps = 23/177 (12%)
Query: 78 GSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDCRIPQIEDAEIHN--- 134
G+ F C +GF+LKG++ C+ G S +C Q C P + H
Sbjct: 829 GAKVDFVCDEGFQLKGSSASYCV--LAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKP 886
Query: 135 -KTYRHGEKLIITC--HEGFKIRYPDLHNMVSLCRDD----GTWNN-LPICQGCLRPLAS 186
+ + G+ + TC H + + C D G W++ P C G L +
Sbjct: 887 LEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRC-GILGHCQA 945
Query: 187 SNGYVNISELQTS-----FPVGTVISYRCFPGFKLDGSAY-LECLQNLIWSSSPPRC 237
+ ++ ++L+T FP+GT + Y C P + G + + CL NL+WSS C
Sbjct: 946 PDHFL-FAKLKTQTNASDFPIGTSLKYECRPEYY--GRPFSITCLDNLVWSSPKDVC 999
Score = 46.6 bits (109), Expect = 3e-05
Identities = 46/177 (25%), Positives = 75/177 (42%), Gaps = 23/177 (12%)
Query: 78 GSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDCRIPQIEDAEIHN--- 134
G+ F C +GF+LKG++ C+ G S +C Q C P + H
Sbjct: 1279 GAKVDFVCDEGFQLKGSSASYCV--LAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKP 1336
Query: 135 -KTYRHGEKLIITC--HEGFKIRYPDLHNMVSLCRDD----GTWNN-LPICQGCLRPLAS 186
+ + G+ + TC H + + C D G W++ P C G L +
Sbjct: 1337 LEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRC-GILGHCQA 1395
Query: 187 SNGYVNISELQTS-----FPVGTVISYRCFPGFKLDGSAY-LECLQNLIWSSSPPRC 237
+ ++ ++L+T FP+GT + Y C P + G + + CL NL+WSS C
Sbjct: 1396 PDHFL-FAKLKTQTNASDFPIGTSLKYECRPEYY--GRPFSITCLDNLVWSSPKDVC 1449
Score = 45.8 bits (107), Expect = 4e-05
Identities = 45/176 (25%), Positives = 66/176 (37%), Gaps = 19/176 (10%)
Query: 78 GSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDCRIPQIEDAEIHNKT- 136
G+ F C +GF+LKG + C+ G S +C Q C P H T
Sbjct: 2182 GAKVSFVCDEGFRLKGRSASHCV--LAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTP 2239
Query: 137 ---YRHGEKLIITC--HEGFKIRYPDLHNMVSLCRDD----GTWNN-LPICQ-----GCL 181
+G+++ C H + + + C D G W++ P C+ C
Sbjct: 2240 FGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACP 2299
Query: 182 RPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRC 237
P NG+ + P G ISY C PG+ L G ++ C IWS C
Sbjct: 2300 HPPKIQNGHYIGGHVSLYLP-GMTISYICDPGYLLVGKGFIFCTDQGIWSQLDHYC 2354
Score = 41.6 bits (96), Expect = 8e-04
Identities = 27/87 (31%), Positives = 41/87 (47%), Gaps = 9/87 (10%)
Query: 165 CRDDGTWNN-LPICQ--GCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAY 221
C D+ W++ +C+ C P NG V++ T VG+ I+Y C G +L G +
Sbjct: 1436 CLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVI---TDIQVGSRINYSCTTGHRLIGHSS 1492
Query: 222 LECL---QNLIWSSSPPRCLALEGGRP 245
EC+ WS+ PP C + G P
Sbjct: 1493 AECILSGNTAHWSTKPPICQRIPCGLP 1519
Score = 41.2 bits (95), Expect = 0.001
Identities = 27/87 (31%), Positives = 42/87 (48%), Gaps = 9/87 (10%)
Query: 165 CRDDGTWNN-LPICQ--GCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAY 221
C D+ W++ +C+ C P NG V++ T VG+ I+Y C G +L G +
Sbjct: 536 CLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVI---TDIQVGSRINYSCTTGHRLIGHSS 592
Query: 222 LECLQN---LIWSSSPPRCLALEGGRP 245
EC+ + WS+ PP C + G P
Sbjct: 593 AECILSGNAAHWSTKPPICQRIPCGLP 619
Score = 41.2 bits (95), Expect = 0.001
Identities = 27/87 (31%), Positives = 42/87 (48%), Gaps = 9/87 (10%)
Query: 165 CRDDGTWNN-LPICQ--GCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAY 221
C D+ W++ +C+ C P NG V++ T VG+ I+Y C G +L G +
Sbjct: 986 CLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVI---TDIQVGSRINYSCTTGHRLIGHSS 1042
Query: 222 LECLQN---LIWSSSPPRCLALEGGRP 245
EC+ + WS+ PP C + G P
Sbjct: 1043 AECILSGNAAHWSTKPPICQRIPCGLP 1069
Score = 37.4 bits (85), Expect = 0.016
Identities = 15/39 (38%), Positives = 25/39 (64%), Gaps = 3/39 (7%)
Query: 200 FPVGTVISYRCFPGFKLDGSAY-LECLQNLIWSSSPPRC 237
FP+GT ++Y C PG+ G + + CL+N +W+ + RC
Sbjct: 63 FPIGTYLNYECRPGY--SGRPFSIICLKNSVWTGAKDRC 99
Score = 37.0 bits (84), Expect = 0.020
Identities = 26/108 (24%), Positives = 44/108 (40%), Gaps = 8/108 (7%)
Query: 133 HNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNLP-ICQ--GCLRPLASSNG 189
H Y G + C G+ + + C D G W+ L C+ C PL NG
Sbjct: 2313 HVSLYLPGMTISYICDPGYLL----VGKGFIFCTDQGIWSQLDHYCKEVNCSFPLFM-NG 2367
Query: 190 YVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRC 237
E++ + G ++ +C G+ L+GS + +C + W +C
Sbjct: 2368 ISKELEMKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRWDPPLAKC 2415
Score = 35.0 bits (79), Expect = 0.077
Identities = 20/71 (28%), Positives = 32/71 (45%), Gaps = 6/71 (8%)
Query: 178 QGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECL---QNLIWSSSP 234
+ C P NG V++ + G+ I Y C G++L GS+ C+ +IW +
Sbjct: 102 KSCRNPPDPVNGMVHVIK---GIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNET 158
Query: 235 PRCLALEGGRP 245
P C + G P
Sbjct: 159 PICDRIPCGLP 169
>gi|86793036 complement receptor 1 isoform F precursor [Homo sapiens]
Length = 2039
Score = 57.4 bits (137), Expect = 1e-08
Identities = 51/203 (25%), Positives = 84/203 (41%), Gaps = 30/203 (14%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C P + + + +F V F CQ GF +KG + C + N +PS + +
Sbjct: 1138 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKC-QALNKWEPELPSCSRV 1196
Query: 117 CVQEDCRIPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSL-CRDDGTWN-NL 174
C Q I E H + G+++ +C G+ DL SL C G W+
Sbjct: 1197 C-QPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGY-----DLRGAASLHCTPQGDWSPEA 1250
Query: 175 PICQGCLRPLASSNGYV-NISELQTSFP----VGTVISYRCFPGFKLDGSAYLECL---Q 226
P C + S + ++ + + FP +G +S+ C GF+L GS+ C+
Sbjct: 1251 PRC-----AVKSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGM 1305
Query: 227 NLIWSSSPPRCLALEGGRPEHLF 249
+W++S P C EH+F
Sbjct: 1306 RSLWNNSVPVC--------EHIF 1320
Score = 53.5 bits (127), Expect = 2e-07
Identities = 55/227 (24%), Positives = 82/227 (36%), Gaps = 29/227 (12%)
Query: 60 PGIPENGFRTPSGGVFFEGSVARFHCQDG------FKLKGATKRLCLKHFNGTLGWIPSD 113
P I F + + F GSV + C G F+L G C + + W
Sbjct: 1070 PTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPA 1129
Query: 114 NSICVQEDCRIPQIEDAEI---HNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGT 170
+ C P +E+ + + + E + C GF ++ P C+
Sbjct: 1130 PQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVK----CQALNK 1185
Query: 171 WN-NLPICQGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLI 229
W LP C +P + Q +F G + Y C PG+ L G+A L C
Sbjct: 1186 WEPELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGD 1245
Query: 230 WSSSPPRCLA---------LEGGRPEHLFPVLYFPHIRLAAAVLYFC 267
WS PRC L GR LFP+ +++L A V + C
Sbjct: 1246 WSPEAPRCAVKSCDDFLGQLPHGRV--LFPL----NLQLGAKVSFVC 1286
Score = 53.5 bits (127), Expect = 2e-07
Identities = 55/211 (26%), Positives = 81/211 (38%), Gaps = 29/211 (13%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C P P NG + F GS + C +GF+L G+ CL N W I
Sbjct: 1457 CGPPPEPFNGMVHINTDTQF-GSTVNYSCNEGFRLIGSPSTTCLVSGNNVT-W-DKKAPI 1513
Query: 117 CVQEDCRIPQI---EDAEIHNKT-YRHGEKLIITCHEGFKIRYPDLHNMVSLC------- 165
C C P D +N+T + +G + CH G PD + L
Sbjct: 1514 CEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTG-----PDGEQLFELVGERSIYC 1568
Query: 166 --RDD--GTWNNLP----ICQGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLD 217
+DD G W++ P C P + + + ++ F + +I +RC PGF +
Sbjct: 1569 TSKDDQVGVWSSPPPRCISTNKCTAPEVENA--IRVPGNRSFFTLTEIIRFRCQPGFVMV 1626
Query: 218 GSAYLECLQNLIWSSSPPRCLALEGGRPEHL 248
GS ++C N W P C + PE L
Sbjct: 1627 GSHTVQCQTNGRWGPKLPHCSRVCQPPPEIL 1657
Score = 53.1 bits (126), Expect = 3e-07
Identities = 60/209 (28%), Positives = 88/209 (42%), Gaps = 39/209 (18%)
Query: 70 PSGGVFFE-----GSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQED--C 122
P G V F G+ F C +GF+LKG++ C+ +L W +NS+ V E C
Sbjct: 1266 PHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHCVLVGMRSL-W---NNSVPVCEHIFC 1321
Query: 123 RIPQIEDAEIHNKT----YRHGEKLIITC--HEGFKIRYPDLHNMVSLCRDD----GTWN 172
P H T +G+++ TC H + + + C D G W+
Sbjct: 1322 PNPPAILNGRHTGTPSGDIPYGKEISYTCDPHPDRGMTFNLIGESTIRCTSDPHGNGVWS 1381
Query: 173 N-LPICQGCLR----------PLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAY 221
+ P C+ +R P AS +N E FPVGT ++Y C PG+ G +
Sbjct: 1382 SPAPRCELSVRAGHCKTPEQFPFASPTIPINDFE----FPVGTSLNYECRPGYF--GKMF 1435
Query: 222 -LECLQNLIWSSSPPRCLALEGGRPEHLF 249
+ CL+NL+WSS C G P F
Sbjct: 1436 SISCLENLVWSSVEDNCRRKSCGPPPEPF 1464
Score = 53.1 bits (126), Expect = 3e-07
Identities = 49/193 (25%), Positives = 72/193 (37%), Gaps = 17/193 (8%)
Query: 57 CADPGIPENG-FRTPSGGVFFEGSVARFHCQDG------FKLKGATKRLCLKHFNGTLGW 109
C P NG F + + F G+V + C G F+L G C + W
Sbjct: 1519 CEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVW 1578
Query: 110 IPSDNSICVQEDCRIPQIEDA---EIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCR 166
C P++E+A + + E + C GF + + + C+
Sbjct: 1579 SSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVM----VGSHTVQCQ 1634
Query: 167 DDGTWN-NLPICQG-CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLEC 224
+G W LP C C P +G +S Q +F G + Y C P + L G+A L C
Sbjct: 1635 TNGRWGPKLPHCSRVCQPPPEILHGEHTLSH-QDNFSPGQEVFYSCEPSYDLRGAASLHC 1693
Query: 225 LQNLIWSSSPPRC 237
WS PRC
Sbjct: 1694 TPQGDWSPEAPRC 1706
Score = 52.8 bits (125), Expect = 4e-07
Identities = 46/191 (24%), Positives = 80/191 (41%), Gaps = 22/191 (11%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C P + + + +F V F CQ GF +KG + C + N +PS + +
Sbjct: 238 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKC-QALNKWEPELPSCSRV 296
Query: 117 CVQEDCRIPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSL-CRDDGTWN-NL 174
C Q + E + + G+++ +C G+ DL S+ C G W+
Sbjct: 297 C-QPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGY-----DLRGAASMRCTPQGDWSPAA 350
Query: 175 PICQGCLRPLASSNGYV-NISELQTSFPV----GTVISYRCFPGFKLDGSAYLECL---Q 226
P C+ + S + ++ + + FPV G + + C GF+L GS+ C+
Sbjct: 351 PTCE-----VKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGM 405
Query: 227 NLIWSSSPPRC 237
+W+SS P C
Sbjct: 406 ESLWNSSVPVC 416
Score = 52.8 bits (125), Expect = 4e-07
Identities = 46/191 (24%), Positives = 80/191 (41%), Gaps = 22/191 (11%)
Query: 57 CADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSI 116
C P + + + +F V F CQ GF +KG + C + N +PS + +
Sbjct: 688 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKC-QALNKWEPELPSCSRV 746
Query: 117 CVQEDCRIPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSL-CRDDGTWN-NL 174
C Q + E + + G+++ +C G+ DL S+ C G W+
Sbjct: 747 C-QPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGY-----DLRGAASMRCTPQGDWSPAA 800
Query: 175 PICQGCLRPLASSNGYV-NISELQTSFPV----GTVISYRCFPGFKLDGSAYLECL---Q 226
P C+ + S + ++ + + FPV G + + C GF+L GS+ C+
Sbjct: 801 PTCE-----VKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYCVLAGM 855
Query: 227 NLIWSSSPPRC 237
+W+SS P C
Sbjct: 856 ESLWNSSVPVC 866
Score = 50.4 bits (119), Expect = 2e-06
Identities = 49/214 (22%), Positives = 88/214 (41%), Gaps = 21/214 (9%)
Query: 40 LCFGPAQLTGGFDDLQ--VCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKR 97
+C + TG D + C +P P NG G+ F GS ++ C G++L G++
Sbjct: 85 ICLKNSVWTGAKDRCRRKSCRNPPDPVNGMVHVIKGIQF-GSQIKYSCTKGYRLIGSSSA 143
Query: 98 LCLKHFNGTLGWIPSDNSICVQEDCRIPQI----EDAEIHNKTYRHGEKLIITCHEGFKI 153
C+ T+ W ++ IC + C +P + + + + +G + C+ G
Sbjct: 144 TCIIS-GDTVIW-DNETPICDRIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGG 201
Query: 154 R----YPDLHNMVSLCRDD--GTWNN-LPIC---QGCLRPLASSNGYVNISELQTSFPVG 203
R ++ DD G W+ P C C P + + +S+ ++ F +
Sbjct: 202 RKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENG--ILVSDNRSLFSLN 259
Query: 204 TVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRC 237
V+ +RC PGF + G ++C W P C
Sbjct: 260 EVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSC 293
Score = 50.1 bits (118), Expect = 2e-06
Identities = 53/227 (23%), Positives = 81/227 (35%), Gaps = 29/227 (12%)
Query: 60 PGIPENGFRTPSGGVFFEGSVARFHCQDG------FKLKGATKRLCLKHFNGTLGWIPSD 113
P I F + + F GSV + C G F+L G C + + W
Sbjct: 170 PTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPA 229
Query: 114 NSICVQEDCRIPQIEDAEI---HNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGT 170
+ C P +E+ + + + E + C GF ++ P C+
Sbjct: 230 PQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVK----CQALNK 285
Query: 171 WN-NLPICQGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLI 229
W LP C +P + +F G + Y C PG+ L G+A + C
Sbjct: 286 WEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGD 345
Query: 230 WSSSPPRCLA---------LEGGRPEHLFPVLYFPHIRLAAAVLYFC 267
WS + P C L GR LFPV +++L A V + C
Sbjct: 346 WSPAAPTCEVKSCDDFMGQLLNGRV--LFPV----NLQLGAKVDFVC 386
Score = 50.1 bits (118), Expect = 2e-06
Identities = 53/227 (23%), Positives = 81/227 (35%), Gaps = 29/227 (12%)
Query: 60 PGIPENGFRTPSGGVFFEGSVARFHCQDG------FKLKGATKRLCLKHFNGTLGWIPSD 113
P I F + + F GSV + C G F+L G C + + W
Sbjct: 620 PTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPA 679
Query: 114 NSICVQEDCRIPQIEDAEI---HNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGT 170
+ C P +E+ + + + E + C GF ++ P C+
Sbjct: 680 PQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVK----CQALNK 735
Query: 171 WN-NLPICQGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLI 229
W LP C +P + +F G + Y C PG+ L G+A + C
Sbjct: 736 WEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGD 795
Query: 230 WSSSPPRCLA---------LEGGRPEHLFPVLYFPHIRLAAAVLYFC 267
WS + P C L GR LFPV +++L A V + C
Sbjct: 796 WSPAAPTCEVKSCDDFMGQLLNGRV--LFPV----NLQLGAKVDFVC 836
Score = 46.6 bits (109), Expect = 3e-05
Identities = 46/177 (25%), Positives = 75/177 (42%), Gaps = 23/177 (12%)
Query: 78 GSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDCRIPQIEDAEIHN--- 134
G+ F C +GF+LKG++ C+ G S +C Q C P + H
Sbjct: 379 GAKVDFVCDEGFQLKGSSASYCV--LAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKP 436
Query: 135 -KTYRHGEKLIITC--HEGFKIRYPDLHNMVSLCRDD----GTWNN-LPICQGCLRPLAS 186
+ + G+ + TC H + + C D G W++ P C G L +
Sbjct: 437 LEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRC-GILGHCQA 495
Query: 187 SNGYVNISELQTS-----FPVGTVISYRCFPGFKLDGSAY-LECLQNLIWSSSPPRC 237
+ ++ ++L+T FP+GT + Y C P + G + + CL NL+WSS C
Sbjct: 496 PDHFL-FAKLKTQTNASDFPIGTSLKYECRPEYY--GRPFSITCLDNLVWSSPKDVC 549
Score = 46.6 bits (109), Expect = 3e-05
Identities = 46/177 (25%), Positives = 75/177 (42%), Gaps = 23/177 (12%)
Query: 78 GSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDCRIPQIEDAEIHN--- 134
G+ F C +GF+LKG++ C+ G S +C Q C P + H
Sbjct: 829 GAKVDFVCDEGFQLKGSSASYCV--LAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKP 886
Query: 135 -KTYRHGEKLIITC--HEGFKIRYPDLHNMVSLCRDD----GTWNN-LPICQGCLRPLAS 186
+ + G+ + TC H + + C D G W++ P C G L +
Sbjct: 887 LEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSSPAPRC-GILGHCQA 945
Query: 187 SNGYVNISELQTS-----FPVGTVISYRCFPGFKLDGSAY-LECLQNLIWSSSPPRC 237
+ ++ ++L+T FP+GT + Y C P + G + + CL NL+WSS C
Sbjct: 946 PDHFL-FAKLKTQTNASDFPIGTSLKYECRPEYY--GRPFSITCLDNLVWSSPKDVC 999
Score = 45.8 bits (107), Expect = 4e-05
Identities = 45/176 (25%), Positives = 66/176 (37%), Gaps = 19/176 (10%)
Query: 78 GSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDCRIPQIEDAEIHNKT- 136
G+ F C +GF+LKG + C+ G S +C Q C P H T
Sbjct: 1732 GAKVSFVCDEGFRLKGRSASHCV--LAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTP 1789
Query: 137 ---YRHGEKLIITC--HEGFKIRYPDLHNMVSLCRDD----GTWNN-LPICQ-----GCL 181
+G+++ C H + + + C D G W++ P C+ C
Sbjct: 1790 FGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACP 1849
Query: 182 RPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRC 237
P NG+ + P G ISY C PG+ L G ++ C IWS C
Sbjct: 1850 HPPKIQNGHYIGGHVSLYLP-GMTISYICDPGYLLVGKGFIFCTDQGIWSQLDHYC 1904
Score = 41.6 bits (96), Expect = 8e-04
Identities = 27/87 (31%), Positives = 41/87 (47%), Gaps = 9/87 (10%)
Query: 165 CRDDGTWNN-LPICQ--GCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAY 221
C D+ W++ +C+ C P NG V++ T VG+ I+Y C G +L G +
Sbjct: 986 CLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVI---TDIQVGSRINYSCTTGHRLIGHSS 1042
Query: 222 LECL---QNLIWSSSPPRCLALEGGRP 245
EC+ WS+ PP C + G P
Sbjct: 1043 AECILSGNTAHWSTKPPICQRIPCGLP 1069
Score = 41.2 bits (95), Expect = 0.001
Identities = 27/87 (31%), Positives = 42/87 (48%), Gaps = 9/87 (10%)
Query: 165 CRDDGTWNN-LPICQ--GCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAY 221
C D+ W++ +C+ C P NG V++ T VG+ I+Y C G +L G +
Sbjct: 536 CLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVI---TDIQVGSRINYSCTTGHRLIGHSS 592
Query: 222 LECLQN---LIWSSSPPRCLALEGGRP 245
EC+ + WS+ PP C + G P
Sbjct: 593 AECILSGNAAHWSTKPPICQRIPCGLP 619
Score = 37.4 bits (85), Expect = 0.016
Identities = 15/39 (38%), Positives = 25/39 (64%), Gaps = 3/39 (7%)
Query: 200 FPVGTVISYRCFPGFKLDGSAY-LECLQNLIWSSSPPRC 237
FP+GT ++Y C PG+ G + + CL+N +W+ + RC
Sbjct: 63 FPIGTYLNYECRPGY--SGRPFSIICLKNSVWTGAKDRC 99
Score = 37.0 bits (84), Expect = 0.020
Identities = 26/108 (24%), Positives = 44/108 (40%), Gaps = 8/108 (7%)
Query: 133 HNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNLP-ICQ--GCLRPLASSNG 189
H Y G + C G+ + + C D G W+ L C+ C PL NG
Sbjct: 1863 HVSLYLPGMTISYICDPGYLL----VGKGFIFCTDQGIWSQLDHYCKEVNCSFPLFM-NG 1917
Query: 190 YVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRC 237
E++ + G ++ +C G+ L+GS + +C + W +C
Sbjct: 1918 ISKELEMKKVYHYGDYVTLKCEDGYTLEGSPWSQCQADDRWDPPLAKC 1965
Score = 35.0 bits (79), Expect = 0.077
Identities = 20/71 (28%), Positives = 32/71 (45%), Gaps = 6/71 (8%)
Query: 178 QGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECL---QNLIWSSSP 234
+ C P NG V++ + G+ I Y C G++L GS+ C+ +IW +
Sbjct: 102 KSCRNPPDPVNGMVHVIK---GIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNET 158
Query: 235 PRCLALEGGRP 245
P C + G P
Sbjct: 159 PICDRIPCGLP 169
>gi|27502411 CD46 antigen, complement regulatory protein isoform 6
precursor [Homo sapiens]
Length = 369
Score = 53.5 bits (127), Expect = 2e-07
Identities = 51/201 (25%), Positives = 78/201 (38%), Gaps = 14/201 (6%)
Query: 63 PENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDC 122
P NG P+ G + G F C +G+ L G C G++ IC + C
Sbjct: 105 PLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYC--ELKGSVAIWSGKPPICEKVLC 162
Query: 123 RIP-QIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVS----LCRDDGTWNNL-PI 176
P +I++ + E L + PD +++ C D+ W+ P
Sbjct: 163 TPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPE 222
Query: 177 CQ--GCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSP 234
C+ C P+ + IS F + + C GF LDGS + C N W
Sbjct: 223 CKVVKCRFPVVENGK--QISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPV 280
Query: 235 PRCLALEGGRPEHLFPVLYFP 255
P+C L+G RP + PV +P
Sbjct: 281 PKC--LKGPRPTYKPPVSNYP 299
>gi|27502409 CD46 antigen, complement regulatory protein isoform 5
precursor [Homo sapiens]
Length = 362
Score = 53.5 bits (127), Expect = 2e-07
Identities = 51/201 (25%), Positives = 78/201 (38%), Gaps = 14/201 (6%)
Query: 63 PENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDC 122
P NG P+ G + G F C +G+ L G C G++ IC + C
Sbjct: 105 PLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYC--ELKGSVAIWSGKPPICEKVLC 162
Query: 123 RIP-QIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVS----LCRDDGTWNNL-PI 176
P +I++ + E L + PD +++ C D+ W+ P
Sbjct: 163 TPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPE 222
Query: 177 CQ--GCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSP 234
C+ C P+ + IS F + + C GF LDGS + C N W
Sbjct: 223 CKVVKCRFPVVENGK--QISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPV 280
Query: 235 PRCLALEGGRPEHLFPVLYFP 255
P+C L+G RP + PV +P
Sbjct: 281 PKC--LKGPRPTYKPPVSNYP 299
>gi|27502405 CD46 antigen, complement regulatory protein isoform 14
precursor [Homo sapiens]
Length = 349
Score = 53.5 bits (127), Expect = 2e-07
Identities = 51/201 (25%), Positives = 78/201 (38%), Gaps = 14/201 (6%)
Query: 63 PENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDC 122
P NG P+ G + G F C +G+ L G C G++ IC + C
Sbjct: 105 PLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYC--ELKGSVAIWSGKPPICEKVLC 162
Query: 123 RIP-QIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVS----LCRDDGTWNNL-PI 176
P +I++ + E L + PD +++ C D+ W+ P
Sbjct: 163 TPPPKIKNGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPE 222
Query: 177 CQ--GCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSP 234
C+ C P+ + IS F + + C GF LDGS + C N W
Sbjct: 223 CKVVKCRFPVVENGK--QISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPV 280
Query: 235 PRCLALEGGRPEHLFPVLYFP 255
P+C L+G RP + PV +P
Sbjct: 281 PKC--LKGPRPTYKPPVSNYP 299
>gi|118442839 complement factor H-related 1 [Homo sapiens]
Length = 330
Score = 52.8 bits (125), Expect = 4e-07
Identities = 50/193 (25%), Positives = 85/193 (44%), Gaps = 21/193 (10%)
Query: 54 LQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRL-CLKHFNGTLGWIPS 112
L++C P + ENG SG EG + C G++L+ + C++ T S
Sbjct: 84 LRLCFFPFV-ENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRS 142
Query: 113 DNSICVQEDCRIPQIEDAEIHNK---TYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDG 169
++ CV P +++A I ++ Y GE++ C +++ + D M +G
Sbjct: 143 TDTSCVNP----PTVQNAHILSRQMSKYPSGERVRYECRSPYEM-FGDEEVMCL----NG 193
Query: 170 TWNNLPICQG----CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECL 225
W P C+ C P NG + L P +V Y+C ++L+G+ + C
Sbjct: 194 NWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSV-EYQCQNLYQLEGNKRITC- 251
Query: 226 QNLIWSSSPPRCL 238
+N W S PP+CL
Sbjct: 252 RNGQW-SEPPKCL 263
>gi|239758113 PREDICTED: similar to complement factor H-related 1
isoform 1 [Homo sapiens]
Length = 330
Score = 52.8 bits (125), Expect = 4e-07
Identities = 50/193 (25%), Positives = 85/193 (44%), Gaps = 21/193 (10%)
Query: 54 LQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRL-CLKHFNGTLGWIPS 112
L++C P + ENG SG EG + C G++L+ + C++ T S
Sbjct: 84 LRLCFFPFV-ENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRS 142
Query: 113 DNSICVQEDCRIPQIEDAEIHNK---TYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDG 169
++ CV P +++A I ++ Y GE++ C +++ + D M +G
Sbjct: 143 TDTSCVNP----PTVQNAHILSRQMSKYPSGERVRYECRSPYEM-FGDEEVMCL----NG 193
Query: 170 TWNNLPICQG----CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECL 225
W P C+ C P NG + L P +V Y+C ++L+G+ + C
Sbjct: 194 NWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSV-EYQCQNLYQLEGNKRITC- 251
Query: 226 QNLIWSSSPPRCL 238
+N W S PP+CL
Sbjct: 252 RNGQW-SEPPKCL 263
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.140 0.462
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,004,207
Number of Sequences: 37866
Number of extensions: 721685
Number of successful extensions: 4273
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 73
Number of HSP's successfully gapped in prelim test: 30
Number of HSP's that attempted gapping in prelim test: 3255
Number of HSP's gapped (non-prelim): 610
length of query: 290
length of database: 18,247,518
effective HSP length: 101
effective length of query: 189
effective length of database: 14,423,052
effective search space: 2725956828
effective search space used: 2725956828
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.