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Search of human proteins with 78486553
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|78486553 neural precursor cell expressed, developmentally
down-regulated 9 isoform 2 [Homo sapiens]
(174 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|78486553 neural precursor cell expressed, developmentally dow... 359 e-100
gi|5453680 neural precursor cell expressed, developmentally down... 322 1e-88
gi|215422375 neural precursor cell expressed, developmentally do... 314 3e-86
gi|44662836 breast cancer anti-estrogen resistance 1 [Homo sapiens] 130 4e-31
gi|239745060 PREDICTED: similar to breast cancer anti-estrogen r... 127 4e-30
gi|239756225 PREDICTED: similar to breast cancer anti-estrogen r... 125 2e-29
gi|239750776 PREDICTED: similar to breast cancer anti-estrogen r... 125 2e-29
gi|239745044 PREDICTED: similar to breast cancer anti-estrogen r... 125 2e-29
gi|5031681 embryonal Fyn-associated substrate isoform 1 [Homo sa... 101 4e-22
gi|55769585 HEF-like protein [Homo sapiens] 95 3e-20
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 52 3e-07
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 52 3e-07
gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [H... 49 3e-06
gi|242117948 SH3 domain-containing protein C1orf113 isoform 2 [H... 49 3e-06
gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Ho... 49 3e-06
gi|4506931 SH3-domain GRB2-like 2 [Homo sapiens] 47 8e-06
gi|167234422 hematopoietic cell-specific Lyn substrate 1 [Homo s... 47 8e-06
gi|215820635 protein phosphatase 1, regulatory subunit 13 like [... 47 1e-05
gi|63003907 protein phosphatase 1, regulatory subunit 13 like [H... 47 1e-05
gi|4505723 peroxisomal biogenesis factor 13 [Homo sapiens] 45 3e-05
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 45 3e-05
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 45 3e-05
gi|194294525 intersectin 2 isoform 2 [Homo sapiens] 45 3e-05
gi|27544941 myosin IF [Homo sapiens] 45 4e-05
gi|20149528 proline-serine-threonine phosphatase interacting pro... 45 4e-05
gi|67514036 SH3-domain kinase binding protein 1 isoform b [Homo ... 44 5e-05
gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo ... 44 5e-05
gi|121114287 apoptosis-stimulating protein of p53, 1 [Homo sapiens] 44 7e-05
gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ... 44 9e-05
gi|223468657 SH3-domain GRB2-like 3 [Homo sapiens] 44 9e-05
>gi|78486553 neural precursor cell expressed, developmentally
down-regulated 9 isoform 2 [Homo sapiens]
Length = 174
Score = 359 bits (922), Expect = e-100
Identities = 174/174 (100%), Positives = 174/174 (100%)
Query: 1 MKYKNLMARALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRV 60
MKYKNLMARALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRV
Sbjct: 1 MKYKNLMARALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRV 60
Query: 61 KLLIGPMQETASSHEQPASGLMQQTFGQQKLYQVPNPQAAPRDTIYQVPPSYQNQGIYQV 120
KLLIGPMQETASSHEQPASGLMQQTFGQQKLYQVPNPQAAPRDTIYQVPPSYQNQGIYQV
Sbjct: 61 KLLIGPMQETASSHEQPASGLMQQTFGQQKLYQVPNPQAAPRDTIYQVPPSYQNQGIYQV 120
Query: 121 PTGHGTQEQEVYQVPPSVQRSIGGTSGPHVGKKVFQRDGQVSYFLVRASKQTSL 174
PTGHGTQEQEVYQVPPSVQRSIGGTSGPHVGKKVFQRDGQVSYFLVRASKQTSL
Sbjct: 121 PTGHGTQEQEVYQVPPSVQRSIGGTSGPHVGKKVFQRDGQVSYFLVRASKQTSL 174
>gi|5453680 neural precursor cell expressed, developmentally
down-regulated 9 isoform 1 [Homo sapiens]
Length = 834
Score = 322 bits (824), Expect = 1e-88
Identities = 154/154 (100%), Positives = 154/154 (100%)
Query: 1 MKYKNLMARALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRV 60
MKYKNLMARALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRV
Sbjct: 1 MKYKNLMARALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRV 60
Query: 61 KLLIGPMQETASSHEQPASGLMQQTFGQQKLYQVPNPQAAPRDTIYQVPPSYQNQGIYQV 120
KLLIGPMQETASSHEQPASGLMQQTFGQQKLYQVPNPQAAPRDTIYQVPPSYQNQGIYQV
Sbjct: 61 KLLIGPMQETASSHEQPASGLMQQTFGQQKLYQVPNPQAAPRDTIYQVPPSYQNQGIYQV 120
Query: 121 PTGHGTQEQEVYQVPPSVQRSIGGTSGPHVGKKV 154
PTGHGTQEQEVYQVPPSVQRSIGGTSGPHVGKKV
Sbjct: 121 PTGHGTQEQEVYQVPPSVQRSIGGTSGPHVGKKV 154
>gi|215422375 neural precursor cell expressed, developmentally
down-regulated 9 isoform 3 [Homo sapiens]
Length = 834
Score = 314 bits (804), Expect = 3e-86
Identities = 150/151 (99%), Positives = 151/151 (100%)
Query: 4 KNLMARALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRVKLL 63
+NLMARALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRVKLL
Sbjct: 4 RNLMARALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRVKLL 63
Query: 64 IGPMQETASSHEQPASGLMQQTFGQQKLYQVPNPQAAPRDTIYQVPPSYQNQGIYQVPTG 123
IGPMQETASSHEQPASGLMQQTFGQQKLYQVPNPQAAPRDTIYQVPPSYQNQGIYQVPTG
Sbjct: 64 IGPMQETASSHEQPASGLMQQTFGQQKLYQVPNPQAAPRDTIYQVPPSYQNQGIYQVPTG 123
Query: 124 HGTQEQEVYQVPPSVQRSIGGTSGPHVGKKV 154
HGTQEQEVYQVPPSVQRSIGGTSGPHVGKKV
Sbjct: 124 HGTQEQEVYQVPPSVQRSIGGTSGPHVGKKV 154
>gi|44662836 breast cancer anti-estrogen resistance 1 [Homo sapiens]
Length = 870
Score = 130 bits (328), Expect = 4e-31
Identities = 75/159 (47%), Positives = 96/159 (60%), Gaps = 15/159 (9%)
Query: 1 MKYKNLMARALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRV 60
M + N++A+ALYDNV E +EL+FRKGDI+TV+EQ+T GL+GWWLCSLHGRQGIVPGNR+
Sbjct: 1 MNHLNVLAKALYDNVAESPDELSFRKGDIMTVLEQDTQGLDGWWLCSLHGRQGIVPGNRL 60
Query: 61 KLLI--------GPMQETASSHEQPASGL-MQQTFGQQKLYQVPNPQAAPRDTIYQVP-P 110
K+L+ GP ++ QP GL Q +PN D++Y VP P
Sbjct: 61 KILVGMYDKKPAGPGPGPPATPAQPQPGLHAPAPPASQYTPMLPNTYQPQPDSVYLVPTP 120
Query: 111 SYQNQGIYQVPTGHGTQEQEVYQVPPSVQRSIGGTSGPH 149
S QG+YQVP G Q +Q PP+ Q S PH
Sbjct: 121 SKAQQGLYQVP---GPSPQ--FQSPPAKQTSTFSKQTPH 154
Score = 38.1 bits (87), Expect = 0.004
Identities = 30/91 (32%), Positives = 40/91 (43%), Gaps = 5/91 (5%)
Query: 51 RQGI--VPGNRVKLLIGPMQETASSHEQPASGLMQQTFGQQKLYQVPNPQAAPRDTIYQV 108
+QG+ VPG + P ++T++ +Q LYQVP P IYQV
Sbjct: 124 QQGLYQVPGPSPQFQSPPAKQTSTFSKQTPHHPFPSP--ATDLYQVPPGPGGPAQDIYQV 181
Query: 109 PPSY-QNQGIYQVPTGHGTQEQEVYQVPPSV 138
PPS IYQVP T+ E + P V
Sbjct: 182 PPSAGMGHDIYQVPPSMDTRSWEGTKPPAKV 212
Score = 32.7 bits (73), Expect = 0.16
Identities = 25/73 (34%), Positives = 36/73 (49%), Gaps = 16/73 (21%)
Query: 77 PASGLMQQTFGQQKLYQVPNPQAA-------PRDTIYQVPPSYQNQGIYQVPTGHGTQEQ 129
P GL+ +GQ+ +Y P P A P +Y VPPS + +G+ P+ H
Sbjct: 253 PVRGLLPSQYGQE-VYDTP-PMAVKGPNGRDPLLEVYDVPPSVE-KGL--PPSNH----H 303
Query: 130 EVYQVPPSVQRSI 142
VY VPPSV + +
Sbjct: 304 AVYDVPPSVSKDV 316
Score = 30.8 bits (68), Expect = 0.62
Identities = 23/68 (33%), Positives = 31/68 (45%), Gaps = 13/68 (19%)
Query: 88 QQKLYQVPNPQAAPR-DTIYQVPP------SYQNQGIYQVPT----GHGTQEQ--EVYQV 134
+Q Y +P AP IY VPP S Q +Y P G ++ EVY V
Sbjct: 230 EQDEYDIPRHLLAPGPQDIYDVPPVRGLLPSQYGQEVYDTPPMAVKGPNGRDPLLEVYDV 289
Query: 135 PPSVQRSI 142
PPSV++ +
Sbjct: 290 PPSVEKGL 297
Score = 26.9 bits (58), Expect = 8.9
Identities = 21/84 (25%), Positives = 30/84 (35%), Gaps = 31/84 (36%)
Query: 95 PNPQAAPRDTIYQVPPSYQNQGIYQVPTG------------------------HGTQEQE 130
P P + P + +Y VPP + +Y VP G G +
Sbjct: 351 PPPDSPPAEDVYDVPPPAPD--LYDVPPGLRRPGPGTLYDVPRERVLPPEVADGGVVDSG 408
Query: 131 VYQVPPSVQRSIGGTSGPHVGKKV 154
VY VPP +R P GK++
Sbjct: 409 VYAVPPPAER-----EAPAEGKRL 427
>gi|239745060 PREDICTED: similar to breast cancer anti-estrogen
resistance 1 [Homo sapiens]
Length = 353
Score = 127 bits (320), Expect = 4e-30
Identities = 73/159 (45%), Positives = 95/159 (59%), Gaps = 15/159 (9%)
Query: 1 MKYKNLMARALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRV 60
M + N++A+ALYDNV E +EL+FRKGDI+TV+EQ+T GL+GWWLCSLHGRQGI+PGN +
Sbjct: 1 MNHLNVLAKALYDNVAESPDELSFRKGDIMTVLEQDTQGLDGWWLCSLHGRQGIMPGNHL 60
Query: 61 KLLI--------GPMQETASSHEQPASGLMQQT-FGQQKLYQVPNPQAAPRDTIYQVP-P 110
K+L+ GP ++ QP GL Q +PN D++Y VP P
Sbjct: 61 KILVGMYDKKPAGPGPGPPATPAQPQPGLHAPVPPASQYTPMLPNTYQPQPDSVYLVPTP 120
Query: 111 SYQNQGIYQVPTGHGTQEQEVYQVPPSVQRSIGGTSGPH 149
S QG+YQVP G Q +Q PP+ Q S PH
Sbjct: 121 SKAQQGLYQVP---GPSPQ--FQSPPAKQTSTFSKQTPH 154
>gi|239756225 PREDICTED: similar to breast cancer anti-estrogen
resistance 1 [Homo sapiens]
Length = 232
Score = 125 bits (314), Expect = 2e-29
Identities = 73/159 (45%), Positives = 94/159 (59%), Gaps = 15/159 (9%)
Query: 1 MKYKNLMARALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRV 60
M + N++A+ALY NV E +EL+FRKGDI+TV+EQ+T GL+GWWLCSLHGRQGIVPGN +
Sbjct: 1 MNHLNVLAKALYVNVAESPDELSFRKGDIMTVLEQDTQGLDGWWLCSLHGRQGIVPGNHL 60
Query: 61 KLLI--------GPMQETASSHEQPASGLMQQT-FGQQKLYQVPNPQAAPRDTIYQVP-P 110
K+L+ GP ++ QP GL Q +PN D++Y VP P
Sbjct: 61 KILVGMYDKKPAGPGPGPPATPAQPQPGLHAPVPPASQYTPMLPNTYQPQPDSVYLVPTP 120
Query: 111 SYQNQGIYQVPTGHGTQEQEVYQVPPSVQRSIGGTSGPH 149
S QG+YQVP G Q +Q PP+ Q S PH
Sbjct: 121 SKAQQGLYQVP---GPSPQ--FQSPPAKQTSTFSKQTPH 154
>gi|239750776 PREDICTED: similar to breast cancer anti-estrogen
resistance 1 [Homo sapiens]
Length = 224
Score = 125 bits (314), Expect = 2e-29
Identities = 73/159 (45%), Positives = 94/159 (59%), Gaps = 15/159 (9%)
Query: 1 MKYKNLMARALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRV 60
M + N++A+ALY NV E +EL+FRKGDI+TV+EQ+T GL+GWWLCSLHGRQGIVPGN +
Sbjct: 1 MNHLNVLAKALYVNVAESPDELSFRKGDIMTVLEQDTQGLDGWWLCSLHGRQGIVPGNHL 60
Query: 61 KLLI--------GPMQETASSHEQPASGLMQQT-FGQQKLYQVPNPQAAPRDTIYQVP-P 110
K+L+ GP ++ QP GL Q +PN D++Y VP P
Sbjct: 61 KILVGMYDKKPAGPGPGPPATPAQPQPGLHAPVPPASQYTPMLPNTYQPQPDSVYLVPTP 120
Query: 111 SYQNQGIYQVPTGHGTQEQEVYQVPPSVQRSIGGTSGPH 149
S QG+YQVP G Q +Q PP+ Q S PH
Sbjct: 121 SKAQQGLYQVP---GPSPQ--FQSPPAKQTSTFSKQTPH 154
>gi|239745044 PREDICTED: similar to breast cancer anti-estrogen
resistance 1 [Homo sapiens]
Length = 368
Score = 125 bits (314), Expect = 2e-29
Identities = 73/159 (45%), Positives = 94/159 (59%), Gaps = 15/159 (9%)
Query: 1 MKYKNLMARALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRV 60
M + N++A+ALY NV E +EL+FRKGDI+TV+EQ+T GL+GWWLCSLHGRQGIVPGN +
Sbjct: 1 MNHLNVLAKALYVNVAESPDELSFRKGDIMTVLEQDTQGLDGWWLCSLHGRQGIVPGNHL 60
Query: 61 KLLI--------GPMQETASSHEQPASGLMQQT-FGQQKLYQVPNPQAAPRDTIYQVP-P 110
K+L+ GP ++ QP GL Q +PN D++Y VP P
Sbjct: 61 KILVGMYDKKPAGPGPGPPATPAQPQPGLHAPVPPASQYTPMLPNTYQPQPDSVYLVPTP 120
Query: 111 SYQNQGIYQVPTGHGTQEQEVYQVPPSVQRSIGGTSGPH 149
S QG+YQVP G Q +Q PP+ Q S PH
Sbjct: 121 SKAQQGLYQVP---GPSPQ--FQSPPAKQTSTFSKQTPH 154
>gi|5031681 embryonal Fyn-associated substrate isoform 1 [Homo
sapiens]
Length = 561
Score = 101 bits (251), Expect = 4e-22
Identities = 70/160 (43%), Positives = 90/160 (56%), Gaps = 22/160 (13%)
Query: 7 MARALYDNVPECAEELAFRKGDILTVIE-QNTGGLEGWWLCSLHGRQGIVPGNRVKLL-I 64
+ARALYDN E +EL+FR+GD+L V++ + GGL+GW LCSLHG+QGIVP NRVKLL
Sbjct: 9 LARALYDNTAESPQELSFRRGDVLRVLQREGAGGLDGWCLCSLHGQQGIVPANRVKLLPA 68
Query: 65 GPMQETASSHEQPAS-----GLMQQTFGQQKLYQVPNPQAAPRDT----IYQVPPSYQNQ 115
GP + + S PA + Q++Y VP P A P T PPS
Sbjct: 69 GPAPKPSLSPASPAQPGSPYPAPDHSNEDQEVYVVP-PPARPCPTSGPPAGPCPPS--PD 125
Query: 116 GIYQVPTGHGTQ------EQEVYQVPPSVQRSIGGTSGPH 149
IY++P GTQ EVY VPP+ R +SGP+
Sbjct: 126 LIYKIPRASGTQLAAPRDALEVYDVPPTALRV--PSSGPY 163
>gi|55769585 HEF-like protein [Homo sapiens]
Length = 786
Score = 95.1 bits (235), Expect = 3e-20
Identities = 55/135 (40%), Positives = 77/135 (57%), Gaps = 15/135 (11%)
Query: 4 KNLMARALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRVKLL 63
K L+ARALYDN P+C++ELAF +GDILT++EQ+ EGWW C LHGRQG+ P NR+++L
Sbjct: 12 KALLARALYDNCPDCSDELAFSRGDILTILEQHVPESEGWWKCLLHGRQGLAPANRLQIL 71
Query: 64 IGPMQETASSHEQP--ASGLMQQTFGQQKLYQVPN-PQAAPRDTIYQVPPSYQNQGIYQV 120
E A+ P GL + ++ YQVP P+ +Y+ S+ Q
Sbjct: 72 ----TEVAADRPCPPFLRGLEEAPASSEETYQVPTLPRPPTPGPVYEQMRSWAEGP--QP 125
Query: 121 PTGHGTQEQEVYQVP 135
PT +VY+ P
Sbjct: 126 PTA------QVYEFP 134
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 51.6 bits (122), Expect = 3e-07
Identities = 35/104 (33%), Positives = 53/104 (50%), Gaps = 19/104 (18%)
Query: 2 KYKNLMARALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRVK 61
K + L A+ALY + L F K D++TV+EQ + WW + G++G P + VK
Sbjct: 912 KVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQ----DMWWFGEVQGQKGWFPKSYVK 967
Query: 62 LLIGPMQETAS----SHEQPASGLMQQTFGQQKLYQVPNPQAAP 101
L+ GP++++ S S E PAS L +V +P A P
Sbjct: 968 LISGPIRKSTSMDSGSSESPAS-----------LKRVASPAAKP 1000
Score = 40.0 bits (92), Expect = 0.001
Identities = 19/52 (36%), Positives = 29/52 (55%), Gaps = 3/52 (5%)
Query: 11 LYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRVKL 62
+YD + +ELAF KG I+ V+ + WW ++G+ G+ P N VKL
Sbjct: 1163 MYDYTAQNDDELAFNKGQIINVLNKED---PDWWKGEVNGQVGLFPSNYVKL 1211
Score = 29.6 bits (65), Expect = 1.4
Identities = 12/42 (28%), Positives = 25/42 (59%), Gaps = 4/42 (9%)
Query: 21 ELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRVKL 62
+L F++GD++ V +++ WW ++ + G+ P N V+L
Sbjct: 1020 DLTFQQGDVILVTKKDGD----WWTGTVGDKAGVFPSNYVRL 1057
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 51.6 bits (122), Expect = 3e-07
Identities = 35/104 (33%), Positives = 53/104 (50%), Gaps = 19/104 (18%)
Query: 2 KYKNLMARALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRVK 61
K + L A+ALY + L F K D++TV+EQ + WW + G++G P + VK
Sbjct: 912 KVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQ----DMWWFGEVQGQKGWFPKSYVK 967
Query: 62 LLIGPMQETAS----SHEQPASGLMQQTFGQQKLYQVPNPQAAP 101
L+ GP++++ S S E PAS L +V +P A P
Sbjct: 968 LISGPIRKSTSMDSGSSESPAS-----------LKRVASPAAKP 1000
Score = 40.4 bits (93), Expect = 8e-04
Identities = 22/64 (34%), Positives = 34/64 (53%), Gaps = 5/64 (7%)
Query: 11 LYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRVKLL--IGPMQ 68
+YD + +ELAF KG I+ V+ + WW ++G+ G+ P N VKL + P Q
Sbjct: 1163 MYDYTAQNDDELAFNKGQIINVLNKED---PDWWKGEVNGQVGLFPSNYVKLTTDMDPSQ 1219
Query: 69 ETAS 72
+ S
Sbjct: 1220 QWCS 1223
Score = 29.6 bits (65), Expect = 1.4
Identities = 12/42 (28%), Positives = 25/42 (59%), Gaps = 4/42 (9%)
Query: 21 ELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRVKL 62
+L F++GD++ V +++ WW ++ + G+ P N V+L
Sbjct: 1020 DLTFQQGDVILVTKKDGD----WWTGTVGDKAGVFPSNYVRL 1057
>gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [Homo
sapiens]
Length = 756
Score = 48.5 bits (114), Expect = 3e-06
Identities = 22/52 (42%), Positives = 32/52 (61%), Gaps = 1/52 (1%)
Query: 9 RALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRV 60
R L+D PE +ELA R+GD++ V+ + T +GWW GR+G+ P N V
Sbjct: 187 RVLFDYQPEAPDELALRRGDVVKVLSKTTED-KGWWEGECQGRRGVFPDNFV 237
Score = 39.7 bits (91), Expect = 0.001
Identities = 30/100 (30%), Positives = 46/100 (46%), Gaps = 22/100 (22%)
Query: 16 PECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRVKLL-IGPMQETASSH 74
PE A+EL + G+I+ +I++ +GWWL +G+ G P N V+LL GP + +
Sbjct: 96 PEQADELKLQAGEIVEMIKEIE---DGWWLGKKNGQLGAFPSNFVELLDSGP--PSLGNP 150
Query: 75 EQPASGLMQQTFGQQKLYQVPNPQAAPR--DTIYQVPPSY 112
+ P+ P PQ P+ Y PP Y
Sbjct: 151 DMPSVS--------------PGPQRPPKLSSLAYDSPPDY 176
>gi|242117948 SH3 domain-containing protein C1orf113 isoform 2 [Homo
sapiens]
Length = 645
Score = 48.5 bits (114), Expect = 3e-06
Identities = 22/52 (42%), Positives = 32/52 (61%), Gaps = 1/52 (1%)
Query: 9 RALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRV 60
R L+D PE +ELA R+GD++ V+ + T +GWW GR+G+ P N V
Sbjct: 76 RVLFDYQPEAPDELALRRGDVVKVLSKTTED-KGWWEGECQGRRGVFPDNFV 126
Score = 30.0 bits (66), Expect = 1.1
Identities = 22/75 (29%), Positives = 31/75 (41%), Gaps = 19/75 (25%)
Query: 41 EGWWLCSLHGRQGIVPGNRVKLL-IGPMQETASSHEQPASGLMQQTFGQQKLYQVPNPQA 99
+GWWL +G+ G P N V+LL GP + + + P+ P PQ
Sbjct: 7 DGWWLGKKNGQLGAFPSNFVELLDSGP--PSLGNPDMPSVS--------------PGPQR 50
Query: 100 APR--DTIYQVPPSY 112
P+ Y PP Y
Sbjct: 51 PPKLSSLAYDSPPDY 65
>gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Homo
sapiens]
Length = 847
Score = 48.5 bits (114), Expect = 3e-06
Identities = 31/76 (40%), Positives = 40/76 (52%), Gaps = 3/76 (3%)
Query: 3 YKNLMARALYDNVPECAEELAFRKGDILTVIEQNT--GGLEGWWLCSLHGRQGIVPGNRV 60
Y N + AL+D P +ELA RKGD + V+ ++ G EGWW + G+ GI P N V
Sbjct: 41 YANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYV 100
Query: 61 KLLIGPMQ-ETASSHE 75
GP E AS E
Sbjct: 101 SRGGGPPPCEVASFQE 116
>gi|4506931 SH3-domain GRB2-like 2 [Homo sapiens]
Length = 352
Score = 47.0 bits (110), Expect = 8e-06
Identities = 25/56 (44%), Positives = 33/56 (58%), Gaps = 3/56 (5%)
Query: 9 RALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRVKLLI 64
RALYD PE EL F++GDI+T+ Q E W+ LHG G P N V++L+
Sbjct: 296 RALYDFEPENEGELGFKEGDIITLTNQID---ENWYEGMLHGHSGFFPINYVEILV 348
>gi|167234422 hematopoietic cell-specific Lyn substrate 1 [Homo
sapiens]
Length = 486
Score = 47.0 bits (110), Expect = 8e-06
Identities = 26/58 (44%), Positives = 33/58 (56%), Gaps = 3/58 (5%)
Query: 6 LMARALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRVKLL 63
+ A ALYD E ++EL+F D++T IE EGWW HG G+ P N VKLL
Sbjct: 431 ISAVALYDYQGEGSDELSFDPDDVITDIEMVD---EGWWRGRCHGHFGLFPANYVKLL 485
>gi|215820635 protein phosphatase 1, regulatory subunit 13 like
[Homo sapiens]
Length = 828
Score = 46.6 bits (109), Expect = 1e-05
Identities = 20/49 (40%), Positives = 32/49 (65%)
Query: 10 ALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGN 58
AL+D E +EL+FR+G+ +TV+ ++ WW +LHG++G VP N
Sbjct: 765 ALWDYSAEFGDELSFREGESVTVLRRDGPEETDWWWAALHGQEGYVPRN 813
>gi|63003907 protein phosphatase 1, regulatory subunit 13 like [Homo
sapiens]
Length = 828
Score = 46.6 bits (109), Expect = 1e-05
Identities = 20/49 (40%), Positives = 32/49 (65%)
Query: 10 ALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGN 58
AL+D E +EL+FR+G+ +TV+ ++ WW +LHG++G VP N
Sbjct: 765 ALWDYSAEFGDELSFREGESVTVLRRDGPEETDWWWAALHGQEGYVPRN 813
>gi|4505723 peroxisomal biogenesis factor 13 [Homo sapiens]
Length = 403
Score = 45.1 bits (105), Expect = 3e-05
Identities = 24/61 (39%), Positives = 39/61 (63%), Gaps = 2/61 (3%)
Query: 5 NLMARALYDNVPECAEELAFRKGDILTV-IEQNTGGLEGWWLCSLHGR-QGIVPGNRVKL 62
+++ARA YD EE++FR GD+L + +++ + GW L SL G+ G++P N VK+
Sbjct: 274 HVVARAEYDFAAVSEEEISFRAGDMLNLALKEQQPKVRGWLLASLDGQTTGLIPANYVKI 333
Query: 63 L 63
L
Sbjct: 334 L 334
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 45.1 bits (105), Expect = 3e-05
Identities = 48/182 (26%), Positives = 74/182 (40%), Gaps = 17/182 (9%)
Query: 4 KNLMARALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRVKLL 63
+NL A+AL + L F K DI+TV+EQ E WW +HG +G P + VK++
Sbjct: 872 ENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQ----ENWWFGEVHGGRGWFPKSYVKII 927
Query: 64 IG-------PMQETASSHEQPASGLMQQTFGQQKLYQVPNPQAAPRD-TIYQVPPSYQNQ 115
G P A+ +++P S + G++ + P P D T + Q
Sbjct: 928 PGSEVKREEPEALYAAVNKKPTSA--AYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQ 985
Query: 116 GIYQVPTGHGTQEQEVY---QVPPSVQRSIGGTSGPHVGKKVFQRDGQVSYFLVRASKQT 172
+ TG ++ V P Q S G S K + S ++ S+Q
Sbjct: 986 KDGEWWTGSIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQL 1045
Query: 173 SL 174
SL
Sbjct: 1046 SL 1047
Score = 37.4 bits (85), Expect = 0.007
Identities = 17/53 (32%), Positives = 29/53 (54%), Gaps = 3/53 (5%)
Query: 10 ALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRVKL 62
A+YD +EL+F KG ++ V+ ++ WW ++G G+ P N VK+
Sbjct: 1107 AMYDYAANNEDELSFSKGQLINVMNKDD---PDWWQGEINGVTGLFPSNYVKM 1156
Score = 35.0 bits (79), Expect = 0.033
Identities = 26/77 (33%), Positives = 35/77 (45%), Gaps = 4/77 (5%)
Query: 9 RALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRVKLLIGPMQ 68
RALY +E++F GDI+ V ++ T G GW S G G P N V+ +
Sbjct: 736 RALYPFEARNHDEMSFNSGDIIQV-DEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSEN 794
Query: 69 ETASSHEQPASGLMQQT 85
E A S P L+ T
Sbjct: 795 EKAVS---PKKALLPPT 808
Score = 34.7 bits (78), Expect = 0.043
Identities = 21/64 (32%), Positives = 33/64 (51%), Gaps = 9/64 (14%)
Query: 19 AEELAFRKGDILTVIEQNTGGLEGWWLCSLHGR-----QGIVPGNRVKLLIGPMQETASS 73
+E+L+ G ++ ++++NT GWW L R +G P + VKLL GP E A+
Sbjct: 1042 SEQLSLAPGQLILILKKNT---SGWWQGELQARGKKRQKGWFPASHVKLL-GPSSERATP 1097
Query: 74 HEQP 77
P
Sbjct: 1098 AFHP 1101
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 45.1 bits (105), Expect = 3e-05
Identities = 48/182 (26%), Positives = 74/182 (40%), Gaps = 17/182 (9%)
Query: 4 KNLMARALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRVKLL 63
+NL A+AL + L F K DI+TV+EQ E WW +HG +G P + VK++
Sbjct: 899 ENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQ----ENWWFGEVHGGRGWFPKSYVKII 954
Query: 64 IG-------PMQETASSHEQPASGLMQQTFGQQKLYQVPNPQAAPRD-TIYQVPPSYQNQ 115
G P A+ +++P S + G++ + P P D T + Q
Sbjct: 955 PGSEVKREEPEALYAAVNKKPTSA--AYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQ 1012
Query: 116 GIYQVPTGHGTQEQEVY---QVPPSVQRSIGGTSGPHVGKKVFQRDGQVSYFLVRASKQT 172
+ TG ++ V P Q S G S K + S ++ S+Q
Sbjct: 1013 KDGEWWTGSIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQL 1072
Query: 173 SL 174
SL
Sbjct: 1073 SL 1074
Score = 37.4 bits (85), Expect = 0.007
Identities = 17/53 (32%), Positives = 29/53 (54%), Gaps = 3/53 (5%)
Query: 10 ALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRVKL 62
A+YD +EL+F KG ++ V+ ++ WW ++G G+ P N VK+
Sbjct: 1134 AMYDYAANNEDELSFSKGQLINVMNKDD---PDWWQGEINGVTGLFPSNYVKM 1183
Score = 35.0 bits (79), Expect = 0.033
Identities = 26/77 (33%), Positives = 35/77 (45%), Gaps = 4/77 (5%)
Query: 9 RALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRVKLLIGPMQ 68
RALY +E++F GDI+ V ++ T G GW S G G P N V+ +
Sbjct: 763 RALYPFEARNHDEMSFNSGDIIQV-DEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSEN 821
Query: 69 ETASSHEQPASGLMQQT 85
E A S P L+ T
Sbjct: 822 EKAVS---PKKALLPPT 835
Score = 34.7 bits (78), Expect = 0.043
Identities = 21/64 (32%), Positives = 33/64 (51%), Gaps = 9/64 (14%)
Query: 19 AEELAFRKGDILTVIEQNTGGLEGWWLCSLHGR-----QGIVPGNRVKLLIGPMQETASS 73
+E+L+ G ++ ++++NT GWW L R +G P + VKLL GP E A+
Sbjct: 1069 SEQLSLAPGQLILILKKNT---SGWWQGELQARGKKRQKGWFPASHVKLL-GPSSERATP 1124
Query: 74 HEQP 77
P
Sbjct: 1125 AFHP 1128
>gi|194294525 intersectin 2 isoform 2 [Homo sapiens]
Length = 1249
Score = 45.1 bits (105), Expect = 3e-05
Identities = 48/182 (26%), Positives = 74/182 (40%), Gaps = 17/182 (9%)
Query: 4 KNLMARALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRVKLL 63
+NL A+AL + L F K DI+TV+EQ E WW +HG +G P + VK++
Sbjct: 899 ENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQ----ENWWFGEVHGGRGWFPKSYVKII 954
Query: 64 IG-------PMQETASSHEQPASGLMQQTFGQQKLYQVPNPQAAPRD-TIYQVPPSYQNQ 115
G P A+ +++P S + G++ + P P D T + Q
Sbjct: 955 PGSEVKREEPEALYAAVNKKPTSA--AYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQ 1012
Query: 116 GIYQVPTGHGTQEQEVY---QVPPSVQRSIGGTSGPHVGKKVFQRDGQVSYFLVRASKQT 172
+ TG ++ V P Q S G S K + S ++ S+Q
Sbjct: 1013 KDGEWWTGSIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQL 1072
Query: 173 SL 174
SL
Sbjct: 1073 SL 1074
Score = 37.4 bits (85), Expect = 0.007
Identities = 17/53 (32%), Positives = 29/53 (54%), Gaps = 3/53 (5%)
Query: 10 ALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRVKL 62
A+YD +EL+F KG ++ V+ ++ WW ++G G+ P N VK+
Sbjct: 1134 AMYDYAANNEDELSFSKGQLINVMNKDD---PDWWQGEINGVTGLFPSNYVKM 1183
Score = 35.0 bits (79), Expect = 0.033
Identities = 26/77 (33%), Positives = 35/77 (45%), Gaps = 4/77 (5%)
Query: 9 RALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRVKLLIGPMQ 68
RALY +E++F GDI+ V ++ T G GW S G G P N V+ +
Sbjct: 763 RALYPFEARNHDEMSFNSGDIIQV-DEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSEN 821
Query: 69 ETASSHEQPASGLMQQT 85
E A S P L+ T
Sbjct: 822 EKAVS---PKKALLPPT 835
Score = 34.7 bits (78), Expect = 0.043
Identities = 21/64 (32%), Positives = 33/64 (51%), Gaps = 9/64 (14%)
Query: 19 AEELAFRKGDILTVIEQNTGGLEGWWLCSLHGR-----QGIVPGNRVKLLIGPMQETASS 73
+E+L+ G ++ ++++NT GWW L R +G P + VKLL GP E A+
Sbjct: 1069 SEQLSLAPGQLILILKKNT---SGWWQGELQARGKKRQKGWFPASHVKLL-GPSSERATP 1124
Query: 74 HEQP 77
P
Sbjct: 1125 AFHP 1128
>gi|27544941 myosin IF [Homo sapiens]
Length = 1098
Score = 44.7 bits (104), Expect = 4e-05
Identities = 19/53 (35%), Positives = 33/53 (62%), Gaps = 3/53 (5%)
Query: 9 RALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRVK 61
RALY V + +EL+F +++ ++ ++ G WW LHG++G+ PGN V+
Sbjct: 1047 RALYQYVGQDVDELSFNVNEVIEILMEDPSG---WWKGRLHGQEGLFPGNYVE 1096
>gi|20149528 proline-serine-threonine phosphatase interacting
protein 1 [Homo sapiens]
Length = 416
Score = 44.7 bits (104), Expect = 4e-05
Identities = 23/55 (41%), Positives = 33/55 (60%), Gaps = 3/55 (5%)
Query: 9 RALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRVKLL 63
RALYD + +EL GDIL VI + G +GWW +G++G VPG+ ++ L
Sbjct: 365 RALYDYTAQNPDELDLSAGDILEVILE---GEDGWWTVERNGQRGFVPGSYLEKL 416
>gi|67514036 SH3-domain kinase binding protein 1 isoform b [Homo
sapiens]
Length = 628
Score = 44.3 bits (103), Expect = 5e-05
Identities = 25/79 (31%), Positives = 42/79 (53%), Gaps = 4/79 (5%)
Query: 12 YDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRVKLLIGPMQETA 71
+ +P+ +EL + GDI+ V+ + EGWW L+G+ G+ P N +K L G E
Sbjct: 70 FSYLPQNDDELELKVGDIIEVVGEVE---EGWWEGVLNGKTGMFPSNFIKELSGESDELG 126
Query: 72 -SSHEQPASGLMQQTFGQQ 89
S EQ + +++T G +
Sbjct: 127 ISQDEQLSKSSLRETTGSE 145
Score = 43.9 bits (102), Expect = 7e-05
Identities = 21/58 (36%), Positives = 37/58 (63%), Gaps = 1/58 (1%)
Query: 20 EELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRVKLLIGPMQETASSHEQP 77
+EL ++GDI+T+I ++ + GWW L+GR+G+ P N VKLL ++ + ++P
Sbjct: 247 DELTIKEGDIVTLINKDCIDV-GWWEGELNGRRGVFPDNFVKLLPPDFEKEGNRPKKP 303
>gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo
sapiens]
Length = 665
Score = 44.3 bits (103), Expect = 5e-05
Identities = 25/79 (31%), Positives = 42/79 (53%), Gaps = 4/79 (5%)
Query: 12 YDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRVKLLIGPMQETA 71
+ +P+ +EL + GDI+ V+ + EGWW L+G+ G+ P N +K L G E
Sbjct: 107 FSYLPQNDDELELKVGDIIEVVGEVE---EGWWEGVLNGKTGMFPSNFIKELSGESDELG 163
Query: 72 -SSHEQPASGLMQQTFGQQ 89
S EQ + +++T G +
Sbjct: 164 ISQDEQLSKSSLRETTGSE 182
Score = 43.9 bits (102), Expect = 7e-05
Identities = 21/58 (36%), Positives = 37/58 (63%), Gaps = 1/58 (1%)
Query: 20 EELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRVKLLIGPMQETASSHEQP 77
+EL ++GDI+T+I ++ + GWW L+GR+G+ P N VKLL ++ + ++P
Sbjct: 284 DELTIKEGDIVTLINKDCIDV-GWWEGELNGRRGVFPDNFVKLLPPDFEKEGNRPKKP 340
Score = 38.9 bits (89), Expect = 0.002
Identities = 22/80 (27%), Positives = 40/80 (50%), Gaps = 3/80 (3%)
Query: 12 YDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRVKLLIGPMQETA 71
+D + +EL G+I+T I + GG WW ++GR+G+ P N V+ + M++
Sbjct: 8 FDYQAQHDDELTISVGEIITNIRKEDGG---WWEGQINGRRGLFPDNFVREIKKEMKKDP 64
Query: 72 SSHEQPASGLMQQTFGQQKL 91
+++ P L + G L
Sbjct: 65 LTNKAPEKPLHEVPSGNSLL 84
>gi|121114287 apoptosis-stimulating protein of p53, 1 [Homo sapiens]
Length = 1090
Score = 43.9 bits (102), Expect = 7e-05
Identities = 24/66 (36%), Positives = 36/66 (54%), Gaps = 2/66 (3%)
Query: 7 MARALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRVKLL--I 64
+A AL+D + ++EL+F +GD LT++ + WW L R+G VP N + L I
Sbjct: 1023 VAYALWDYEAQNSDELSFHEGDALTILRRKDESETEWWWARLGDREGYVPKNLLGLYPRI 1082
Query: 65 GPMQET 70
P Q T
Sbjct: 1083 KPRQRT 1088
>gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
isoform 2 [Homo sapiens]
Length = 2472
Score = 43.5 bits (101), Expect = 9e-05
Identities = 28/83 (33%), Positives = 40/83 (48%), Gaps = 7/83 (8%)
Query: 10 ALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRVKLLIGPMQE 69
ALYD + E+ +KGDILT++ + WW ++ RQG VP VK L P Q
Sbjct: 974 ALYDYQEKSPREVTMKKGDILTLLNSTN---KDWWKVEVNDRQGFVPAAYVKKL-DPAQS 1029
Query: 70 TASSH---EQPASGLMQQTFGQQ 89
+ + EQ + L Q+ Q
Sbjct: 1030 ASRENLLEEQGSIALRQEQIDNQ 1052
>gi|223468657 SH3-domain GRB2-like 3 [Homo sapiens]
Length = 347
Score = 43.5 bits (101), Expect = 9e-05
Identities = 22/56 (39%), Positives = 32/56 (57%), Gaps = 3/56 (5%)
Query: 9 RALYDNVPECAEELAFRKGDILTVIEQNTGGLEGWWLCSLHGRQGIVPGNRVKLLI 64
R LYD PE EL F++GDI+T+ Q E W+ +HG G P N V++++
Sbjct: 291 RGLYDFEPENQGELGFKEGDIITLTNQID---ENWYEGMIHGESGFFPINYVEVIV 343
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.133 0.400
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 7,558,507
Number of Sequences: 37866
Number of extensions: 381164
Number of successful extensions: 1424
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 94
Number of HSP's successfully gapped in prelim test: 154
Number of HSP's that attempted gapping in prelim test: 1082
Number of HSP's gapped (non-prelim): 369
length of query: 174
length of database: 18,247,518
effective HSP length: 95
effective length of query: 79
effective length of database: 14,650,248
effective search space: 1157369592
effective search space used: 1157369592
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 58 (26.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.