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Search of human proteins with 7705925
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7705925 dicarbonyl/L-xylulose reductase [Homo sapiens]
(244 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7705925 dicarbonyl/L-xylulose reductase [Homo sapiens] 480 e-136
gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo ... 114 1e-25
gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens] 100 2e-21
gi|126723750 dehydrogenase/reductase (SDR family) member 4 like ... 94 8e-20
gi|66933014 3-hydroxybutyrate dehydrogenase, type 2 [Homo sapiens] 92 3e-19
gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo... 92 5e-19
gi|10190704 2,4-dienoyl CoA reductase 2 [Homo sapiens] 87 2e-17
gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo sapi... 85 7e-17
gi|4503301 2,4-dienoyl CoA reductase 1 precursor [Homo sapiens] 79 5e-15
gi|40254992 carbonic reductase 4 [Homo sapiens] 79 5e-15
gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo sap... 75 5e-14
gi|126723191 dehydrogenase/reductase (SDR family) member 4 like ... 73 3e-13
gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens] 72 6e-13
gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo... 69 5e-12
gi|19923817 peroxisomal trans-2-enoyl-CoA reductase [Homo sapiens] 67 1e-11
gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo sa... 67 1e-11
gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens] 63 2e-10
gi|4758504 hydroxysteroid (17-beta) dehydrogenase 10 isoform 1 [... 62 3e-10
gi|10190746 retinol dehydrogenase 14 (all-trans and 9-cis) [Homo... 62 3e-10
gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens] 62 6e-10
gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A... 62 6e-10
gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform ... 59 3e-09
gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens] 59 3e-09
gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens] 59 4e-09
gi|226371731 hydroxysteroid dehydrogenase like 1 isoform a [Homo... 57 2e-08
gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens] 56 2e-08
gi|40254986 hydroxysteroid dehydrogenase like 2 [Homo sapiens] 55 6e-08
gi|223718074 hydroxysteroid (17-beta) dehydrogenase 1 [Homo sapi... 54 1e-07
gi|83715985 hydroxysteroid (17-beta) dehydrogenase 10 isoform 2 ... 54 1e-07
gi|4507185 sepiapterin reductase [Homo sapiens] 54 2e-07
>gi|7705925 dicarbonyl/L-xylulose reductase [Homo sapiens]
Length = 244
Score = 480 bits (1235), Expect = e-136
Identities = 244/244 (100%), Positives = 244/244 (100%)
Query: 1 MELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVD 60
MELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVD
Sbjct: 1 MELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVD 60
Query: 61 LGDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVAR 120
LGDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVAR
Sbjct: 61 LGDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVAR 120
Query: 121 GLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPT 180
GLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPT
Sbjct: 121 GLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPT 180
Query: 181 VVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGG 240
VVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGG
Sbjct: 181 VVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGG 240
Query: 241 FWAC 244
FWAC
Sbjct: 241 FWAC 244
>gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo
sapiens]
Length = 278
Score = 114 bits (284), Expect = 1e-25
Identities = 81/248 (32%), Positives = 126/248 (50%), Gaps = 16/248 (6%)
Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPG----IEPVCVD 60
LA + LVT + GIG + L GA VV SR Q ++D V G +
Sbjct: 30 LANKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVCH 89
Query: 61 LGDWEATERALGSV----GPVDLLVNNAAVALLQPF----LEVTKEAFDRSFEVNLRAVI 112
+G E ER + + G +D+LV+NAAV PF ++VT+E +D++ ++N++A
Sbjct: 90 VGKAEDRERLVATAVKLHGGIDILVSNAAV---NPFFGSIMDVTEEVWDKTLDINVKAPA 146
Query: 113 QVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKI 172
+++ V + RG G++V VSS + S Y +K AL LTK +A+EL P I
Sbjct: 147 LMTKAVVPEMEKRG-GGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIELAPRNI 205
Query: 173 RVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTG 232
RVN + P ++ TS + W D K ++M + + + E E + FL S+ + TG
Sbjct: 206 RVNCLAPGLIKTSFSRMLWMDKEKEESMKETLRIRRLGEPEDCAGIVSFLCSEDASYITG 265
Query: 233 STLPVEGG 240
T+ V GG
Sbjct: 266 ETVVVGGG 273
>gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens]
Length = 261
Score = 100 bits (248), Expect = 2e-21
Identities = 76/249 (30%), Positives = 117/249 (46%), Gaps = 20/249 (8%)
Query: 11 LVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVREC--PGIEP---------VCV 59
LVTGAG GIGR L GA V A +A VR PG +
Sbjct: 15 LVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGSKEGPPRGNHAAFQA 74
Query: 60 DLGDWEATERALGSVG-----PVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQV 114
D+ + A L V P ++V+ A + + L ++++ +D+ VNL+ V
Sbjct: 75 DVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDWDKVIAVNLKGTFLV 134
Query: 115 SQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRV 174
+Q A+ L++ G G+I+N+SS + + Y ++K + LT+ A ELG H IR
Sbjct: 135 TQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLTQTAARELGRHGIRC 194
Query: 175 NAVNPTVVMTSMGQATWSDPHKAKTMLNR-IPLGKFAEVEHVVNAILFLLSDRSGMTTGS 233
N+V P + T M Q P K + IP+G + E V + + FL S+ SG TG+
Sbjct: 195 NSVLPGFIATPMTQKV---PQKVVDKITEMIPMGHLGDPEDVADVVAFLASEDSGYITGT 251
Query: 234 TLPVEGGFW 242
++ V GG +
Sbjct: 252 SVEVTGGLF 260
>gi|126723750 dehydrogenase/reductase (SDR family) member 4 like 1
[Homo sapiens]
Length = 281
Score = 94.4 bits (233), Expect = 8e-20
Identities = 75/248 (30%), Positives = 118/248 (47%), Gaps = 13/248 (5%)
Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPG-----IEPVCV 59
L + LVT + IG Q L GA VV R Q ++D V G VC
Sbjct: 30 LTNKVALVTASTDWIGFAVAQRLAQDGAHVVVSRRKQQNVDQAVATLQGEGLSMTGTVCH 89
Query: 60 --DLGDWE---ATERAL-GSVGPVDLLVNNAAVALLQ-PFLEVTKEAFDRSFEVNLRAVI 112
+ DWE AT L G + + L + N+ L L+ +EA+DR+ ++N +A+
Sbjct: 90 VGKMKDWERLVATAMKLHGVIDILSLSITNSKRGLFWFTLLQTAEEAWDRNLDINGKALA 149
Query: 113 QVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKI 172
+ + V + RG G++ ++S + R + S Y +K AL L K +A+EL P I
Sbjct: 150 LMIKAVVPEMEKRG-GGSVGFLASVAAFRPLPGFSPYNVSKTALLGLNKTLAIELAPRNI 208
Query: 173 RVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTG 232
RVN + P ++ TS + W D K ++M + + + E E + + FL S+ + TG
Sbjct: 209 RVNCLAPGLIKTSFSRMLWMDKEKEESMKETLRIRRLGEPEDSLGIVSFLCSEDASYLTG 268
Query: 233 STLPVEGG 240
T+ V GG
Sbjct: 269 ETVMVGGG 276
>gi|66933014 3-hydroxybutyrate dehydrogenase, type 2 [Homo sapiens]
Length = 245
Score = 92.4 bits (228), Expect = 3e-19
Identities = 70/242 (28%), Positives = 121/242 (50%), Gaps = 7/242 (2%)
Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDW 64
L G+ +++T A +GIG+ A GA+V+A ++ L L + PGI+ +D+
Sbjct: 4 LDGKVIILTAAAQGIGQAAALAFAREGAKVIATDINESKLQEL-EKYPGIQTRVLDVTKK 62
Query: 65 EATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLIA 124
+ ++ V +D+L N A L+ ++ +D S +N+R++ + + ++A
Sbjct: 63 KQIDQFANEVERLDVLFNVAGFVHHGTVLDCEEKDWDFSMNLNVRSMYLMIKAFLPKMLA 122
Query: 125 RGVPGAIVNVSSQCSQ-RAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPTVVM 183
+ G I+N+SS S + V N VY +TK A+ LTK +A + IR N V P V
Sbjct: 123 QK-SGNIINMSSVASSVKGVVNRCVYSTTKAAVIGLTKSVAADFIQQGIRCNCVCPGTVD 181
Query: 184 TSMGQ---ATWSDPHKAKT-MLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEG 239
T Q +P +A+ L R G+FA E + ++L SD S TG+ + ++G
Sbjct: 182 TPSLQERIQARGNPEEARNDFLKRQKTGRFATAEEIAMLCVYLASDESAYVTGNPVIIDG 241
Query: 240 GF 241
G+
Sbjct: 242 GW 243
>gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo
sapiens]
Length = 270
Score = 91.7 bits (226), Expect = 5e-19
Identities = 75/245 (30%), Positives = 122/245 (49%), Gaps = 14/245 (5%)
Query: 6 AGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWE 65
AG+ V+VTG G+GIG G V+A +GARVV + ++ +L +E PG + D+ +
Sbjct: 8 AGKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQELPGAVFILCDVTQED 67
Query: 66 ATERALGSV----GPVDLLVNNAA-VALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVAR 120
+ + G +D +VNNA Q E + + F + E+NL ++++
Sbjct: 68 DVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLTKLALP 127
Query: 121 GLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPT 180
L R G ++N+SS Y +TKGA+ +TK +AL+ P+ +RVN ++P
Sbjct: 128 YL--RKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVNCISPG 185
Query: 181 VVMTSMGQ---ATWSDPHKA--KTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTL 235
+ T + + A DP + ML + PLG+ + V A +FL S+ + TG L
Sbjct: 186 NIWTPLWEELAALMPDPRATIREGMLAQ-PLGRMGQPAEVGAAAVFLASE-ANFCTGIEL 243
Query: 236 PVEGG 240
V GG
Sbjct: 244 LVTGG 248
>gi|10190704 2,4-dienoyl CoA reductase 2 [Homo sapiens]
Length = 292
Score = 86.7 bits (213), Expect = 2e-17
Identities = 64/248 (25%), Positives = 110/248 (44%), Gaps = 11/248 (4%)
Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIE-----PVCV 59
L + +TG G GIG + G V SR+ + + R+ G P+ +
Sbjct: 26 LRDKVAFITGGGSGIGFRIAEIFMRHGCHTVIASRSLPRVLTAARKLAGATGRRCLPLSM 85
Query: 60 DL----GDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVS 115
D+ A ++AL G +D+L+N AA L P ++ AF +++ VS
Sbjct: 86 DVRAPPAVMAAVDQALKEFGRIDILINCAAGNFLCPAGALSFNAFKTVMDIDTSGTFNVS 145
Query: 116 QIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVN 175
+++ R G IVN+++ R S K A+D +T+ +A+E GP IRVN
Sbjct: 146 RVLYEKFF-RDHGGVIVNITATLGNRGQALQVHAGSAKAAVDAMTRHLAVEWGPQNIRVN 204
Query: 176 AVNPTVVMTSMGQATWSDPHKA-KTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGST 234
++ P + + G P + T + PL + + +++L+L S + TG+
Sbjct: 205 SLAPGPISGTEGLRRLGGPQASLSTKVTASPLQRLGNKTEIAHSVLYLASPLASYVTGAV 264
Query: 235 LPVEGGFW 242
L +GG W
Sbjct: 265 LVADGGAW 272
>gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo
sapiens]
Length = 280
Score = 84.7 bits (208), Expect = 7e-17
Identities = 74/245 (30%), Positives = 113/245 (46%), Gaps = 13/245 (5%)
Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPG----IEPVCVD 60
LA R +VTG+ GIG + L GA VV SR Q ++D + + G + +
Sbjct: 34 LANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLSVAGIVCH 93
Query: 61 LGDWEATE----RALGSVGPVDLLVNNAAV-ALLQPFLEVTKEAFDRSFEVNLRA-VIQV 114
+G E E +AL G VD LV +A V L+ L +++ +D+ VN+++ + +
Sbjct: 94 VGKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNVKSPALLL 153
Query: 115 SQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRV 174
SQ++ RG A++ VSS + V VY +K AL LT+ +ALEL P IRV
Sbjct: 154 SQLLPYMENRRG---AVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALELAPKDIRV 210
Query: 175 NAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGST 234
N V P ++ T + + K L + E E + FL S + G
Sbjct: 211 NCVVPGIIKTDFSKVFHGNESLWKNFKEHHQLQRIGESEDCAGIVSFLCSPDASYVNGEN 270
Query: 235 LPVEG 239
+ V G
Sbjct: 271 IAVAG 275
>gi|4503301 2,4-dienoyl CoA reductase 1 precursor [Homo sapiens]
Length = 335
Score = 78.6 bits (192), Expect = 5e-15
Identities = 57/245 (23%), Positives = 109/245 (44%), Gaps = 12/245 (4%)
Query: 7 GRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPG-----IEPVCVDL 61
G+ +TG G G+G+G L + GA+ V SR L + + + + D+
Sbjct: 59 GKVAFITGGGTGLGKGMTTLLSSLGAQCVIASRKMDVLKATAEQISSQTGNKVHAIQCDV 118
Query: 62 GDWEATERALGSV----GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQI 117
D + + + + G ++++NNAA + P ++ A+ ++ L V+
Sbjct: 119 RDPDMVQNTVSELIKVAGHPNIVINNAAGNFISPTERLSPNAWKTITDIVLNGTAFVTLE 178
Query: 118 VARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAV 177
+ + LI A +++++ ++ S K ++ ++K +A E G + +R N +
Sbjct: 179 IGKQLIKAQKGAAFLSITTIYAETGSGFVVPSASAKAGVEAMSKSLAAEWGKYGMRFNVI 238
Query: 178 NPTVVMTSMGQATWSDPHKA--KTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTL 235
P + T G + DP K M+ RIP G+ VE + N FL SD + G+ +
Sbjct: 239 QPGPIKTK-GAFSRLDPTGTFEKEMIGRIPCGRLGTVEELANLAAFLCSDYASWINGAVI 297
Query: 236 PVEGG 240
+GG
Sbjct: 298 KFDGG 302
>gi|40254992 carbonic reductase 4 [Homo sapiens]
Length = 237
Score = 78.6 bits (192), Expect = 5e-15
Identities = 73/238 (30%), Positives = 105/238 (44%), Gaps = 21/238 (8%)
Query: 12 VTGAGKGIGRGTVQALHATGARVVAVSRT-------QADL--DSLVRECPGIEPVCVDLG 62
V G +GIGR Q + G R+ ++R DL D L C + V
Sbjct: 7 VFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFSCDVAKEHDVQ-N 65
Query: 63 DWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGL 122
+E E+ LG V + LVN A + + E NL + + R +
Sbjct: 66 TFEELEKHLGRV---NFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLTCKAAMRTM 122
Query: 123 IARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPTVV 182
I + G+IVNV S + + SVY ++KG L ++ +A E+ KIRVN V P V
Sbjct: 123 IQQQ-GGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVNVVAPGFV 181
Query: 183 MTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGG 240
T M + K + + IPLG+F E V +A++FLL S TG L V+GG
Sbjct: 182 HTDM-----TKDLKEEHLKKNIPLGRFGETIEVAHAVVFLL--ESPYITGHVLVVDGG 232
>gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo
sapiens]
Length = 300
Score = 75.1 bits (183), Expect = 5e-14
Identities = 64/194 (32%), Positives = 98/194 (50%), Gaps = 13/194 (6%)
Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPG----IEPVCVD 60
LA R +VTG+ GIG + L GA VV SR Q ++D + + G + +
Sbjct: 34 LANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLSVAGIVCH 93
Query: 61 LGDWEATE----RALGSVGPVDLLVNNAAV-ALLQPFLEVTKEAFDRSFEVNLRA-VIQV 114
+G E E +AL G VD LV +A V L+ L +++ +D+ VN+++ + +
Sbjct: 94 VGKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNVKSPALLL 153
Query: 115 SQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRV 174
SQ++ RG A++ VSS + V VY +K AL LT+ +ALEL P IRV
Sbjct: 154 SQLLPYMENRRG---AVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALELAPKDIRV 210
Query: 175 NAVNPTVVMTSMGQ 188
N V P ++ T +
Sbjct: 211 NCVVPGIIKTDFSK 224
>gi|126723191 dehydrogenase/reductase (SDR family) member 4 like 2
[Homo sapiens]
Length = 232
Score = 72.8 bits (177), Expect = 3e-13
Identities = 62/201 (30%), Positives = 99/201 (49%), Gaps = 17/201 (8%)
Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPG----IEPVCVD 60
L + LVT + GIG + L A VV SR Q ++D V G +
Sbjct: 30 LTNKVALVTASTDGIGFAIARRLAQDRAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVCH 89
Query: 61 LGDWEATERALGSV----GPVDLLVNNAAVALLQPF----LEVTKEAFDRSFEVNLRAVI 112
+G E ER + G +D+LV+NAAV PF ++VT+E +D++ ++N++A
Sbjct: 90 VGKAEDRERLVAMAVKLHGGIDILVSNAAV---NPFFGSLMDVTEEVWDKTLDINVKAPA 146
Query: 113 QVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKI 172
+++ V + RG G++V VSS + S Y +K AL L +A+EL P I
Sbjct: 147 LMTKAVVPEMEKRG-GGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLNNTLAIELAPRNI 205
Query: 173 RVNAVNPTVV-MTSMGQATWS 192
RVN ++ + + S G + W+
Sbjct: 206 RVNCLHLDLSRLASAGCSGWT 226
>gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens]
Length = 260
Score = 71.6 bits (174), Expect = 6e-13
Identities = 68/241 (28%), Positives = 110/241 (45%), Gaps = 19/241 (7%)
Query: 8 RRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVREC-----PG-IEPVCVDL 61
R LVTGA GIG +AL G +VV +RT +++ L EC PG + P DL
Sbjct: 12 RLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKSAGYPGTLIPYRCDL 71
Query: 62 GDWEATERALGSV----GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQI 117
+ E ++ VD+ +NNA +A L + + F VN+ A+ ++
Sbjct: 72 SNEEDILSMFSAIRSQHSGVDICINNAGLARPDTLLSGSTSGWKDMFNVNVLALSICTRE 131
Query: 118 VARGLIARGV-PGAIVNVSSQCSQRA--VTNHSVYCSTKGALDMLTKVMALEL--GPHKI 172
+ + R V G I+N++S R ++ Y +TK A+ LT+ + EL I
Sbjct: 132 AYQSMKERNVDDGHIININSMSGHRVLPLSVTHFYSATKYAVTALTEGLRQELREAQTHI 191
Query: 173 RVNAVNPTVVMTSMG-QATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTT 231
R ++P VV T + DP KA ++ K + E V A++++LS + +
Sbjct: 192 RATCISPGVVETQFAFKLHDKDPEKAAATYEQM---KCLKPEDVAEAVIYVLSTPAHIQI 248
Query: 232 G 232
G
Sbjct: 249 G 249
>gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo
sapiens]
Length = 325
Score = 68.6 bits (166), Expect = 5e-12
Identities = 50/197 (25%), Positives = 89/197 (45%), Gaps = 15/197 (7%)
Query: 4 FLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEP------- 56
+L V++TGA G+G+ + +A GA++V R L+ L+RE
Sbjct: 49 YLRNAVVVITGATSGLGKECAKVFYAAGAKLVLCGRNGGALEELIRELTASHATKVQTHK 108
Query: 57 ---VCVDLGDWEATERALGSV----GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLR 109
V DL D A A + G VD+LVNNA ++ ++ T + R E N
Sbjct: 109 PYLVTFDLTDSGAIVAAAAEILQCFGYVDILVNNAGISYRGTIMDTTVDVDKRVMETNYF 168
Query: 110 AVIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGP 169
+ +++ + +I R G IV +SS + ++ S Y ++K A + E+
Sbjct: 169 GPVALTKALLPSMIKRR-QGHIVAISSIQGKMSIPFRSAYAASKHATQAFFDCLRAEMEQ 227
Query: 170 HKIRVNAVNPTVVMTSM 186
++I V ++P + T++
Sbjct: 228 YEIEVTVISPGYIHTNL 244
>gi|19923817 peroxisomal trans-2-enoyl-CoA reductase [Homo sapiens]
Length = 303
Score = 67.0 bits (162), Expect = 1e-11
Identities = 63/252 (25%), Positives = 107/252 (42%), Gaps = 19/252 (7%)
Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPG---------IE 55
L G+ +VTG GIG+ V+ L G+ VV SR L S E +
Sbjct: 16 LQGQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAADELQANLPPTKQARVI 75
Query: 56 PVCVDLGDWE----ATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAV 111
P+ ++ + E + L + G ++ LVNN L P ++ + + E NL
Sbjct: 76 PIQCNIRNEEEVNNLVKSTLDTFGKINFLVNNGGGQFLSPAEHISSKGWHAVLETNLTGT 135
Query: 112 IQVSQIVARGLIARGVPGAIVNVSSQCSQR-AVTNHSVYCSTKGALDMLTKVMALELGPH 170
+ + V + + G+IVN+ + HS + + + LTK +ALE
Sbjct: 136 FYMCKAVYSSWM-KEHGGSIVNIIVPTKAGFPLAVHS--GAARAGVYNLTKSLALEWACS 192
Query: 171 KIRVNAVNPTVVMTSMGQATWSDPHKA--KTMLNRIPLGKFAEVEHVVNAILFLLSDRSG 228
IR+N V P V+ + + ++ + +IP + E V + + FLLS +
Sbjct: 193 GIRINCVAPGVIYSQTAVENYGSWGQSFFEGSFQKIPAKRIGVPEEVSSVVCFLLSPAAS 252
Query: 229 MTTGSTLPVEGG 240
TG ++ V+GG
Sbjct: 253 FITGQSVDVDGG 264
>gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo
sapiens]
Length = 332
Score = 67.0 bits (162), Expect = 1e-11
Identities = 54/191 (28%), Positives = 87/191 (45%), Gaps = 16/191 (8%)
Query: 3 LFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADL-------------DSLVR 49
L L G V+VTG GIG+ + GA + V+R + L D V
Sbjct: 28 LALPGAHVVVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKEIEMHSINDKQVV 87
Query: 50 ECPGIEPVCVDLGDWE-ATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNL 108
C ++ V D E ++A +GPVD+LVN A +A+ F ++ F+R +N
Sbjct: 88 LCISVD-VSQDYNQVENVIKQAQEKLGPVDMLVNCAGMAVSGKFEDLEVSTFERLMSINY 146
Query: 109 RAVIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELG 168
+ S+ V + R V G IV VSSQ Q + + Y ++K A+ L + + +E+
Sbjct: 147 LGSVYPSRAVITTMKERRV-GRIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEALQMEVK 205
Query: 169 PHKIRVNAVNP 179
P+ + + P
Sbjct: 206 PYNVYITVAYP 216
>gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens]
Length = 312
Score = 63.2 bits (152), Expect = 2e-10
Identities = 53/193 (27%), Positives = 96/193 (49%), Gaps = 12/193 (6%)
Query: 7 GRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLD---SLVRECPGIE--PVCVDL 61
G +VTG+ GIG+ + L G +VV +SR++ LD S ++E +E + VD
Sbjct: 50 GEWAVVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKEKFKVETRTIAVDF 109
Query: 62 GDWEATER-ALGSVG-PVDLLVNNAAVALLQP--FLEV--TKEAFDRSFEVNLRAVIQVS 115
+ ++ G G + +LVNN ++ P FL+V + +N+ +V +++
Sbjct: 110 ASEDIYDKIKTGLAGLEIGILVNNVGMSYEYPEYFLDVPDLDNVIKKMININILSVCKMT 169
Query: 116 QIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVN 175
Q+V G++ R GAI+N+SS V ++Y +TK +D ++ + E + V
Sbjct: 170 QLVLPGMVERS-KGAILNISSGSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRSKGVFVQ 228
Query: 176 AVNPTVVMTSMGQ 188
+V P V T + +
Sbjct: 229 SVLPYFVATKLAK 241
>gi|4758504 hydroxysteroid (17-beta) dehydrogenase 10 isoform 1
[Homo sapiens]
Length = 261
Score = 62.4 bits (150), Expect = 3e-10
Identities = 66/236 (27%), Positives = 100/236 (42%), Gaps = 26/236 (11%)
Query: 7 GRRVLVTGAGKGIGRGTVQALHATGARVVAV----SRTQADLDSLVRECPGIEPVCVDLG 62
G ++TG G+G T + L GA V + S +A L C
Sbjct: 10 GLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVFAPADVTSEK 69
Query: 63 DWE-ATERALGSVGPVDLLVNNAAVALLQPFLEVTK------EAFDRSFEVNLRAVIQVS 115
D + A A G G VD+ VN A +A+ + K E F R +VNL V
Sbjct: 70 DVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNLMGTFNVI 129
Query: 116 QIVARGLIARGVP------GAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGP 169
++VA G + + P G I+N +S + + Y ++KG + +T +A +L P
Sbjct: 130 RLVA-GEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLAP 188
Query: 170 HKIRVNAVNPTVVMTSMGQATWSDPHKAKTML-NRIP----LGKFAEVEHVVNAIL 220
IRV + P + T + S P K L +++P LG AE H+V AI+
Sbjct: 189 IGIRVMTIAPGLFGTPL---LTSLPEKVCNFLASQVPFPSRLGDPAEYAHLVQAII 241
>gi|10190746 retinol dehydrogenase 14 (all-trans and 9-cis) [Homo
sapiens]
Length = 336
Score = 62.4 bits (150), Expect = 3e-10
Identities = 59/218 (27%), Positives = 97/218 (44%), Gaps = 40/218 (18%)
Query: 7 GRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSL----------VRECPGIEP 56
G+ VL+TGA G+GR T L GARV+ R +A + EC G EP
Sbjct: 43 GKTVLITGANSGLGRATAAELLRLGARVIMGCRDRARAEEAAGQLRRELRQAAEC-GPEP 101
Query: 57 VCVDLGDWEATERALGSVGPV--------------DLLVNNAAVALLQPFLEVTKEAFDR 102
+G+ E L S+ V D+L+NNA + P+++ T++ F+
Sbjct: 102 GVSGVGELIVRELDLASLRSVRAFCQEMLQEEPRLDVLINNAGI-FQCPYMK-TEDGFEM 159
Query: 103 SFEVNLRAVIQVSQIVARGLIARGVPGAIVNVSSQC------------SQRAVTNHSVYC 150
F VN ++ ++ GL+ P IV VSS+ S+++ Y
Sbjct: 160 QFGVNHLGHFLLTNLLL-GLLKSSAPSRIVVVSSKLYKYGDINFDDLNSEQSYNKSFCYS 218
Query: 151 STKGALDMLTKVMALELGPHKIRVNAVNPTVVMTSMGQ 188
+K A + T+ +A L + VN ++P +V T++G+
Sbjct: 219 RSKLANILFTRELARRLEGTNVTVNVLHPGIVRTNLGR 256
>gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens]
Length = 331
Score = 61.6 bits (148), Expect = 6e-10
Identities = 51/209 (24%), Positives = 89/209 (42%), Gaps = 26/209 (12%)
Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPG------IEPVC 58
+ G+ V+VTGA GIG+ T L G ++ R ++ ++ G +
Sbjct: 36 IPGKTVIVTGANTGIGKQTALELARRGGNIILACRDMEKCEAAAKDIRGETLNHHVNARH 95
Query: 59 VDLGDWEATERALGSV----GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQV 114
+DL ++ + VD+L+NNA V + T++ F+ F VN +
Sbjct: 96 LDLASLKSIREFAAKIIEEEERVDILINNAGVMRCPHW--TTEDGFEMQFGVNHLGHFLL 153
Query: 115 SQIVARGLIARGVPGAIVNVSSQC-------------SQRAVTNHSVYCSTKGALDMLTK 161
+ ++ L A P I+N+SS R + YC +K A+ + TK
Sbjct: 154 TNLLLDKLKA-SAPSRIINLSSLAHVAGHIDFDDLNWQTRKYNTKAAYCQSKLAIVLFTK 212
Query: 162 VMALELGPHKIRVNAVNPTVVMTSMGQAT 190
++ L + VNA++P V T +G+ T
Sbjct: 213 ELSRRLQGSGVTVNALHPGVARTELGRHT 241
>gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A
[Homo sapiens]
Length = 300
Score = 61.6 bits (148), Expect = 6e-10
Identities = 53/191 (27%), Positives = 82/191 (42%), Gaps = 12/191 (6%)
Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGI----EPVCVD 60
+AG VL+TGAG GIGR T + +V + ++ EC + VD
Sbjct: 34 VAGEIVLITGAGHGIGRQTTYEFAKRQSILVLWDINKRGVEETAAECRKLGVTAHAYVVD 93
Query: 61 LGDWEATERALG----SVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQ 116
+ E R+L VG V ++VNNA L E ++FEVN+ +++
Sbjct: 94 CSNREEIYRSLNQVKKEVGDVTIVVNNAGTVYPADLLSTKDEEITKTFEVNILGHFWITK 153
Query: 117 IVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALE---LGPHKIR 173
+ ++ R G IV V+S C + YCS+K A + + E LG I+
Sbjct: 154 ALLPSMMERN-HGHIVTVASVCGHEGIPYLIPYCSSKFAAVGFHRGLTSELQALGKTGIK 212
Query: 174 VNAVNPTVVMT 184
+ + P V T
Sbjct: 213 TSCLCPVFVNT 223
>gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 1
[Homo sapiens]
Length = 266
Score = 59.3 bits (142), Expect = 3e-09
Identities = 54/195 (27%), Positives = 92/195 (47%), Gaps = 24/195 (12%)
Query: 7 GRRVLVTGAGKGIGRGTVQALHATGARVVAVS-------RTQADLDSLVRECPGIEPVCV 59
G+ LVTGA +GIGR +AL GA+V V + +A LD + C
Sbjct: 5 GKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQC- 63
Query: 60 DLGDW----EATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVS 115
D+ D + + + G +D+LVNNA V ++ ++++ ++NL +VI +
Sbjct: 64 DVADQQQLRDTFRKVVDHFGRLDILVNNAGVN--------NEKNWEKTLQINLVSVISGT 115
Query: 116 QIVARGLIAR--GVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTK--VMALELGPHK 171
+ + + G G I+N+SS V VYC++K + T+ +A L
Sbjct: 116 YLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSG 175
Query: 172 IRVNAVNPTVVMTSM 186
+R+NA+ P V T++
Sbjct: 176 VRLNAICPGFVNTAI 190
>gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens]
Length = 311
Score = 59.3 bits (142), Expect = 3e-09
Identities = 56/188 (29%), Positives = 91/188 (48%), Gaps = 10/188 (5%)
Query: 6 AGRRVLVTGAGKGIGRG-TVQALHATGAR--VVAVSRT---QADLDSLVRECPG--IEPV 57
A R VL++G GIG VQ H R VVA R + L++ E G +
Sbjct: 4 APRTVLISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLGKKETLEAAAGEALGQTLTVA 63
Query: 58 CVDLGDWEATERALGSV-GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQ 116
+D+ E+ + L + G VD+LVNNA + L+ P ++ A F+ N +++ +
Sbjct: 64 QLDVCSDESVAQCLSCIQGEVDVLVNNAGMGLVGPLEGLSLAAMQNVFDTNFFGAVRLVK 123
Query: 117 IVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNA 176
V G+ R G IV +SS + V + VY ++K AL+ + +A++L I ++
Sbjct: 124 AVLPGM-KRRRQGHIVVISSVMGLQGVIFNDVYAASKFALEGFFESLAIQLLQFNIFISL 182
Query: 177 VNPTVVMT 184
V P V+T
Sbjct: 183 VEPGPVVT 190
>gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]
Length = 300
Score = 58.9 bits (141), Expect = 4e-09
Identities = 57/227 (25%), Positives = 93/227 (40%), Gaps = 24/227 (10%)
Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPG----IEPVCVD 60
+ G VL+TGAG GIGR T +++V + L+ +C G + VD
Sbjct: 34 VTGEIVLITGAGHGIGRLTAYEFAKLKSKLVLWDINKHGLEETAAKCKGLGAKVHTFVVD 93
Query: 61 LGD----WEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQ 116
+ + + ++ +G V +LVNNA V +++FEVN+ A ++
Sbjct: 94 CSNREDIYSSAKKVKAEIGDVSILVNNAGVVYTSDLFATQDPQIEKTFEVNVLAHFWTTK 153
Query: 117 IVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNA 176
+ + G IV V+S +V YCS+K A K + EL +++
Sbjct: 154 AFLPAM-TKNNHGHIVTVASAAGHVSVPFLLAYCSSKFAAVGFHKTLTDELA--ALQITG 210
Query: 177 VNPTVVMTSMGQATWSDPHKAKTMLNRIP---LGKFAEVEHVVNAIL 220
V T + P+ T + P LG E E VVN ++
Sbjct: 211 VKTTCLC----------PNFVNTGFIKNPSTSLGPTLEPEEVVNRLM 247
>gi|226371731 hydroxysteroid dehydrogenase like 1 isoform a [Homo
sapiens]
Length = 330
Score = 56.6 bits (135), Expect = 2e-08
Identities = 48/190 (25%), Positives = 85/190 (44%), Gaps = 11/190 (5%)
Query: 7 GRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDL--GDW 64
GR +V+GA GIG+ + L + G ++ +SR + L + ++ V D+ D+
Sbjct: 67 GRWAVVSGATDGIGKAYAEELASRGLNIILISRNEEKLQVVAKDIADTYKVETDIIVADF 126
Query: 65 EATE------RALGSVGPVDLLVNNAAVALLQP--FLEVTKEAFDRSFEVNLRAVIQVSQ 116
+ R V +LVNN V P F +++++ VN+ A +
Sbjct: 127 SSGREIYLPIREALKDKDVGILVNNVGVFYPYPQYFTQLSEDKLWDIINVNIAAASLMVH 186
Query: 117 IVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNA 176
+V G++ R GAIV +SS + + + ++K LD ++ + E I V +
Sbjct: 187 VVLPGMVER-KKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYASKGIFVQS 245
Query: 177 VNPTVVMTSM 186
+ P V TSM
Sbjct: 246 LIPFYVATSM 255
>gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens]
Length = 309
Score = 56.2 bits (134), Expect = 2e-08
Identities = 59/228 (25%), Positives = 98/228 (42%), Gaps = 18/228 (7%)
Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDS---LVRECPG--IEPVCV 59
+AG VL+TGAG G+GR G+ +V + + + RE +
Sbjct: 38 VAGEIVLITGAGSGLGRLLALQFARLGSVLVLWDINKEGNEETCKMAREAGATRVHAYTC 97
Query: 60 DL----GDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVS 115
D G + ++ VG V +L+NNA + + FL+ E ++SF+VN +A +
Sbjct: 98 DCSQKEGVYRVADQVKKEVGDVSILINNAGIVTGKKFLDCPDELMEKSFDVNFKAHLWTY 157
Query: 116 QIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHK---I 172
+ +IA G +V +SS V + YC++K A + + +E K I
Sbjct: 158 KAFLPAMIAND-HGHLVCISSSAGLSGVNGLADYCASKFAAFGFAESVFVETFVQKQKGI 216
Query: 173 RVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAIL 220
+ V P + T M + + +L K+A VE +V AIL
Sbjct: 217 KTTIVCPFFIKTGMFEGCTTGCPSLLPILE----PKYA-VEKIVEAIL 259
>gi|40254986 hydroxysteroid dehydrogenase like 2 [Homo sapiens]
Length = 418
Score = 55.1 bits (131), Expect = 6e-08
Identities = 54/192 (28%), Positives = 80/192 (41%), Gaps = 19/192 (9%)
Query: 5 LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQAD----LDSLVRECPGIE----- 55
LAG V +TGA +GIG+ GA +V ++T L ++ IE
Sbjct: 8 LAGCTVFITGASRGIGKAIALKAAKDGANIVIAAKTAQPHPKLLGTIYTAAEEIEAVGGK 67
Query: 56 --PVCVDLGDWE----ATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLR 109
P VD+ D + A E+A+ G +D+LVNNA+ L L+ + D VN R
Sbjct: 68 ALPCIVDVRDEQQISAAVEKAIKKFGGIDILVNNASAISLTNTLDTPTKRLDLMMNVNTR 127
Query: 110 AVIQVSQIVARGLIARGVPGAIVNVSSQCSQRAV--TNHSVYCSTKGALDMLTKVMALEL 167
S+ + + I+N+S + V H Y K + M MA E
Sbjct: 128 GTYLASK-ACIPYLKKSKVAHILNISPPLNLNPVWFKQHCAYTIAKYGMSMYVLGMAEEF 186
Query: 168 GPHKIRVNAVNP 179
+I VNA+ P
Sbjct: 187 -KGEIAVNALWP 197
>gi|223718074 hydroxysteroid (17-beta) dehydrogenase 1 [Homo
sapiens]
Length = 328
Score = 53.9 bits (128), Expect = 1e-07
Identities = 51/199 (25%), Positives = 90/199 (45%), Gaps = 13/199 (6%)
Query: 10 VLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVR--------ECP--GIEPVCV 59
VL+TG GIG L + ++ V T DL + R CP +E + +
Sbjct: 6 VLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQL 65
Query: 60 DLGDWEATERALGSV--GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQI 117
D+ D ++ A V G VD+LV NA + LL P + ++A +VN+ +++ Q
Sbjct: 66 DVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRMLQA 125
Query: 118 VARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAV 177
+ RG G ++ S + + VYC++K AL+ L + +A+ L P + ++ +
Sbjct: 126 FLPDMKRRG-SGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVHLSLI 184
Query: 178 NPTVVMTSMGQATWSDPHK 196
V T+ + P +
Sbjct: 185 ECGPVHTAFMEKVLGSPEE 203
>gi|83715985 hydroxysteroid (17-beta) dehydrogenase 10 isoform 2
[Homo sapiens]
Length = 252
Score = 53.9 bits (128), Expect = 1e-07
Identities = 63/236 (26%), Positives = 98/236 (41%), Gaps = 35/236 (14%)
Query: 7 GRRVLVTGAGKGIGRGTVQALHATGARVVAV----SRTQADLDSLVRECPGIEPVCVDLG 62
G ++TG G+G T + L GA V + S +A L C
Sbjct: 10 GLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVFAPADVTSEK 69
Query: 63 DWE-ATERALGSVGPVDLLVNNAAVALLQPFLEVTK------EAFDRSFEVNLRAVIQVS 115
D + A A G G VD+ VN A +A+ + K E F R +VNL V
Sbjct: 70 DVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNLMGTFNVI 129
Query: 116 QIVARGLIARGVP------GAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGP 169
++VA G + + P G I+N +S + + Y ++KG + +T +A +L P
Sbjct: 130 RLVA-GEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLAP 188
Query: 170 HKIRVNAVNPTVVMTSMGQATWSDPHKAKTML-NRIP----LGKFAEVEHVVNAIL 220
+ T ++TS+ P K L +++P LG AE H+V AI+
Sbjct: 189 -----IGLFGTPLLTSL-------PEKVCNFLASQVPFPSRLGDPAEYAHLVQAII 232
>gi|4507185 sepiapterin reductase [Homo sapiens]
Length = 261
Score = 53.5 bits (127), Expect = 2e-07
Identities = 63/240 (26%), Positives = 112/240 (46%), Gaps = 23/240 (9%)
Query: 7 GRRV-LVTGAGKGIGRGT---VQALHATGARVVAVSRTQADLDSLVREC----PGIEPVC 58
GR V L+TGA +G GR + +L + G+ +V +R L L E G+ V
Sbjct: 6 GRAVCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAERSGLRVVR 65
Query: 59 V--DLGDWEATERALGSVGPVD--------LLVNNAAVA--LLQPFLEVTKEA-FDRSFE 105
V DLG ++ LG++ + LL+NNA + + F++++ + +
Sbjct: 66 VPADLGAEAGLQQLLGALRELPRPKGLQRLLLINNAGSLGDVSKGFVDLSDSTQVNNYWA 125
Query: 106 VNLRAVIQVSQIVARGLI-ARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMA 164
+NL +++ ++ V + + G+ +VN+SS C+ + ++YC+ K A DML +V+A
Sbjct: 126 LNLTSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAGKAARDMLFQVLA 185
Query: 165 LELGPHKIRVNAVNP-TVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLL 223
LE ++ A P M + + T DP K + GK + + +L LL
Sbjct: 186 LEEPNVRVLNYAPGPLDTDMQQLARETSVDPDMRKGLQELKAKGKLVDCKVSAQKLLSLL 245
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.134 0.393
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 7,989,403
Number of Sequences: 37866
Number of extensions: 288211
Number of successful extensions: 881
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 62
Number of HSP's successfully gapped in prelim test: 16
Number of HSP's that attempted gapping in prelim test: 749
Number of HSP's gapped (non-prelim): 82
length of query: 244
length of database: 18,247,518
effective HSP length: 99
effective length of query: 145
effective length of database: 14,498,784
effective search space: 2102323680
effective search space used: 2102323680
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.