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Search of human proteins with 7705855
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo
sapiens]
(312 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens] 614 e-176
gi|226371731 hydroxysteroid dehydrogenase like 1 isoform a [Homo... 226 2e-59
gi|4557649 estradiol 17 beta-dehydrogenase 3 [Homo sapiens] 213 1e-55
gi|226371733 hydroxysteroid dehydrogenase like 1 isoform b [Homo... 142 3e-34
gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo... 81 1e-15
gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens] 79 5e-15
gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo s... 79 7e-15
gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens] 74 2e-13
gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens] 74 2e-13
gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo ... 73 4e-13
gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens] 70 2e-12
gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform ... 70 2e-12
gi|44680136 3-hydroxybutyrate dehydrogenase, type 1 precursor [H... 70 3e-12
gi|44680133 3-hydroxybutyrate dehydrogenase, type 1 precursor [H... 70 3e-12
gi|17738292 3-hydroxybutyrate dehydrogenase, type 1 precursor [H... 70 3e-12
gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo sa... 69 5e-12
gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A... 69 5e-12
gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo sapi... 66 3e-11
gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo sap... 66 3e-11
gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens] 65 8e-11
gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens] 64 2e-10
gi|224922801 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform... 64 2e-10
gi|7705925 dicarbonyl/L-xylulose reductase [Homo sapiens] 63 3e-10
gi|31543615 dehydrogenase/reductase (SDR family) member 3 [Homo ... 62 7e-10
gi|126723191 dehydrogenase/reductase (SDR family) member 4 like ... 62 9e-10
gi|157739938 dehydrogenase/reductase (SDR family) member 7C [Hom... 61 1e-09
gi|150247226 retinol dehydrogenase 16 [Homo sapiens] 59 4e-09
gi|4504503 hydroxysteroid (17-beta) dehydrogenase 2 [Homo sapiens] 57 2e-08
gi|22507405 short chain dehydrogenase/reductase family 9C, membe... 57 2e-08
gi|19743808 hydroxysteroid (17-beta) dehydrogenase 6 [Homo sapiens] 56 4e-08
>gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens]
Length = 312
Score = 614 bits (1584), Expect = e-176
Identities = 312/312 (100%), Positives = 312/312 (100%)
Query: 1 MESALPAAGFLYWVGAGTVAYLALRISYSLFTALRVWGVGNEAGVGPGLGEWAVVTGSTD 60
MESALPAAGFLYWVGAGTVAYLALRISYSLFTALRVWGVGNEAGVGPGLGEWAVVTGSTD
Sbjct: 1 MESALPAAGFLYWVGAGTVAYLALRISYSLFTALRVWGVGNEAGVGPGLGEWAVVTGSTD 60
Query: 61 GIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKEKFKVETRTIAVDFASEDIYDKIKT 120
GIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKEKFKVETRTIAVDFASEDIYDKIKT
Sbjct: 61 GIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKEKFKVETRTIAVDFASEDIYDKIKT 120
Query: 121 GLAGLEIGILVNNVGMSYEYPEYFLDVPDLDNVIKKMININILSVCKMTQLVLPGMVERS 180
GLAGLEIGILVNNVGMSYEYPEYFLDVPDLDNVIKKMININILSVCKMTQLVLPGMVERS
Sbjct: 121 GLAGLEIGILVNNVGMSYEYPEYFLDVPDLDNVIKKMININILSVCKMTQLVLPGMVERS 180
Query: 181 KGAILNISSGSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRSKGVFVQSVLPYFVATKLA 240
KGAILNISSGSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRSKGVFVQSVLPYFVATKLA
Sbjct: 181 KGAILNISSGSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRSKGVFVQSVLPYFVATKLA 240
Query: 241 KIRKPTLDKPSPETFVKSAIKTVGLQSRTNGYLIHALMGSIISNLPSWIYLKIVMNMNKS 300
KIRKPTLDKPSPETFVKSAIKTVGLQSRTNGYLIHALMGSIISNLPSWIYLKIVMNMNKS
Sbjct: 241 KIRKPTLDKPSPETFVKSAIKTVGLQSRTNGYLIHALMGSIISNLPSWIYLKIVMNMNKS 300
Query: 301 TRAHYLKKTKKN 312
TRAHYLKKTKKN
Sbjct: 301 TRAHYLKKTKKN 312
>gi|226371731 hydroxysteroid dehydrogenase like 1 isoform a [Homo
sapiens]
Length = 330
Score = 226 bits (577), Expect = 2e-59
Identities = 122/304 (40%), Positives = 188/304 (61%), Gaps = 10/304 (3%)
Query: 14 VGAGTVAYLALRISYSLFTALRVWGV---GNEAGVGPGLGEWAVVTGSTDGIGKSYAEEL 70
VGA A ++ + ++ +R+ + G+ A + G WAVV+G+TDGIGK+YAEEL
Sbjct: 28 VGAWYTARKSITVICDFYSLIRLHFIPRLGSRADLIKQYGRWAVVSGATDGIGKAYAEEL 87
Query: 71 AKHGMKVVLISRSKDKLDQVSSEIKEKFKVETRTIAVDFAS-EDIYDKIKTGLAGLEIGI 129
A G+ ++LISR+++KL V+ +I + +KVET I DF+S +IY I+ L ++GI
Sbjct: 88 ASRGLNIILISRNEEKLQVVAKDIADTYKVETDIIVADFSSGREIYLPIREALKDKDVGI 147
Query: 130 LVNNVGMSYEYPEYFLDVPDLDNVIKKMININILSVCKMTQLVLPGMVERSKGAILNISS 189
LVNNVG+ Y YP+YF + + + + +IN+NI + M +VLPGMVER KGAI+ ISS
Sbjct: 148 LVNNVGVFYPYPQYFTQLSE--DKLWDIINVNIAAASLMVHVVLPGMVERKKGAIVTISS 205
Query: 190 GSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRSKGVFVQSVLPYFVATKLAK----IRKP 245
GS P P L +SA+K ++D FS+ L EY SKG+FVQS++P++VAT + + +
Sbjct: 206 GSCCKPTPQLAAFSASKAYLDHFSRALQYEYASKGIFVQSLIPFYVATSMTAPSNFLHRC 265
Query: 246 TLDKPSPETFVKSAIKTVGLQSRTNGYLIHALMGSIISNLPSWIYLKIVMNMNKSTRAHY 305
+ PSP+ + A+ T+G+ RT GY H++ +P W+++ +N+S R
Sbjct: 266 SWLVPSPKVYAHHAVSTLGISKRTTGYWSHSIQFLFAQYMPEWLWVWGANILNRSLRKEA 325
Query: 306 LKKT 309
L T
Sbjct: 326 LSCT 329
>gi|4557649 estradiol 17 beta-dehydrogenase 3 [Homo sapiens]
Length = 310
Score = 213 bits (543), Expect = 1e-55
Identities = 119/273 (43%), Positives = 171/273 (62%), Gaps = 5/273 (1%)
Query: 19 VAYLALRISYSLFTALRVWGVGNEAGVGPGLGEWAVVTGSTDGIGKSYAEELAKHGMKVV 78
+A LA + +S L W V ++ + +G+WAV+TG+ DGIGK+Y+ ELAK G+ VV
Sbjct: 18 LACLAKCVRFSRCVLLNYWKVLPKSFLR-SMGQWAVITGAGDGIGKAYSFELAKRGLNVV 76
Query: 79 LISRSKDKLDQVSSEIKEKFKVETRTIAVDFASEDIYDKIKTGLAGLEIGILVNNVGMSY 138
LISR+ +KL+ +++EI+ + I DF +DIY+ IK LAGLEIGILVNNVGM
Sbjct: 77 LISRTLEKLEAIATEIERTTGRSVKIIQADFTKDDIYEHIKEKLAGLEIGILVNNVGMLP 136
Query: 139 EY-PEYFLDVPDLDNVIKKMININILSVCKMTQLVLPGMVERSKGAILNISSGSGMLPVP 197
P +FL+ PD I+ +I+ NI SV KMTQL+L M R KG ILNISSG + P P
Sbjct: 137 NLLPSHFLNAPD---EIQSLIHCNITSVVKMTQLILKHMESRQKGLILNISSGIALFPWP 193
Query: 198 LLTIYSATKTFVDFFSQCLHEEYRSKGVFVQSVLPYFVATKLAKIRKPTLDKPSPETFVK 257
L ++YSA+K FV FS+ L EEY++K V +Q + PY V+T + K + + + FVK
Sbjct: 194 LYSMYSASKAFVCAFSKALQEEYKAKEVIIQVLTPYAVSTAMTKYLNTNVITKTADEFVK 253
Query: 258 SAIKTVGLQSRTNGYLIHALMGSIISNLPSWIY 290
++ V + T G L H ++ +S +P+W +
Sbjct: 254 ESLNYVTIGGETCGCLAHEILAGFLSLIPAWAF 286
>gi|226371733 hydroxysteroid dehydrogenase like 1 isoform b [Homo
sapiens]
Length = 275
Score = 142 bits (359), Expect = 3e-34
Identities = 95/303 (31%), Positives = 147/303 (48%), Gaps = 63/303 (20%)
Query: 14 VGAGTVAYLALRISYSLFTALRVWGV---GNEAGVGPGLGEWAVVTGSTDGIGKSYAEEL 70
VGA A ++ + ++ +R+ + G+ A + G WAVV+G+TDGIGK+YAEEL
Sbjct: 28 VGAWYTARKSITVICDFYSLIRLHFIPRLGSRADLIKQYGRWAVVSGATDGIGKAYAEEL 87
Query: 71 AKHGMKVVLISRSKDKLDQVSSEIKEKFKVETRTIAVDFASEDIYDKIKTGLAGLEIGIL 130
A GL I ++
Sbjct: 88 ASR--------------------------------------------------GLNIILI 97
Query: 131 VNNVGMSYEYPEYFLDVPDLDNVIKKMININILSVCKMTQLVLPGMVERSKGAILNISSG 190
N E +YF + + + + +IN+NI + M +VLPGMVER KGAI+ ISSG
Sbjct: 98 SRNE----EKLQYFTQLSE--DKLWDIINVNIAAASLMVHVVLPGMVERKKGAIVTISSG 151
Query: 191 SGMLPVPLLTIYSATKTFVDFFSQCLHEEYRSKGVFVQSVLPYFVATKLAK----IRKPT 246
S P P L +SA+K ++D FS+ L EY SKG+FVQS++P++VAT + + + +
Sbjct: 152 SCCKPTPQLAAFSASKAYLDHFSRALQYEYASKGIFVQSLIPFYVATSMTAPSNFLHRCS 211
Query: 247 LDKPSPETFVKSAIKTVGLQSRTNGYLIHALMGSIISNLPSWIYLKIVMNMNKSTRAHYL 306
PSP+ + A+ T+G+ RT GY H++ +P W+++ +N+S R L
Sbjct: 212 WLVPSPKVYAHHAVSTLGISKRTTGYWSHSIQFLFAQYMPEWLWVWGANILNRSLRKEAL 271
Query: 307 KKT 309
T
Sbjct: 272 SCT 274
>gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo
sapiens]
Length = 325
Score = 80.9 bits (198), Expect = 1e-15
Identities = 56/194 (28%), Positives = 92/194 (47%), Gaps = 11/194 (5%)
Query: 54 VVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKEKFKVETRTIAVDFASED 113
V+TG+T G+GK A+ G K+VL R+ L+++ E+ + +T + D
Sbjct: 56 VITGATSGLGKECAKVFYAAGAKLVLCGRNGGALEELIRELTASHATKVQTHKPYLVTFD 115
Query: 114 IYDKIKTGLAGLEI-------GILVNNVGMSYEYPEYFLDVPDLDNVIKKMININILSVC 166
+ D A EI ILVNN G+SY V +V K+++ N
Sbjct: 116 LTDSGAIVAAAAEILQCFGYVDILVNNAGISYRGTIMDTTV----DVDKRVMETNYFGPV 171
Query: 167 KMTQLVLPGMVERSKGAILNISSGSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRSKGVF 226
+T+ +LP M++R +G I+ ISS G + +P + Y+A+K F CL E +
Sbjct: 172 ALTKALLPSMIKRRQGHIVAISSIQGKMSIPFRSAYAASKHATQAFFDCLRAEMEQYEIE 231
Query: 227 VQSVLPYFVATKLA 240
V + P ++ T L+
Sbjct: 232 VTVISPGYIHTNLS 245
>gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]
Length = 300
Score = 79.0 bits (193), Expect = 5e-15
Identities = 61/197 (30%), Positives = 98/197 (49%), Gaps = 10/197 (5%)
Query: 50 GEWAVVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKEKFKVETRTIAVDF 109
GE ++TG+ GIG+ A E AK K+VL +K L++ +++ K + T VD
Sbjct: 36 GEIVLITGAGHGIGRLTAYEFAKLKSKLVLWDINKHGLEETAAKCKG-LGAKVHTFVVDC 94
Query: 110 AS-EDIYDKIKTGLAGL-EIGILVNNVGMSYEYPEYFLDVPDLDNVIKKMININILSVCK 167
++ EDIY K A + ++ ILVNN G+ Y + P I+K +N+L+
Sbjct: 95 SNREDIYSSAKKVKAEIGDVSILVNNAGVVYTSDLFATQDPQ----IEKTFEVNVLAHFW 150
Query: 168 MTQLVLPGMVERSKGAILNISSGSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRS---KG 224
T+ LP M + + G I+ ++S +G + VP L Y ++K F + L +E + G
Sbjct: 151 TTKAFLPAMTKNNHGHIVTVASAAGHVSVPFLLAYCSSKFAAVGFHKTLTDELAALQITG 210
Query: 225 VFVQSVLPYFVATKLAK 241
V + P FV T K
Sbjct: 211 VKTTCLCPNFVNTGFIK 227
>gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo
sapiens]
Length = 339
Score = 78.6 bits (192), Expect = 7e-15
Identities = 60/185 (32%), Positives = 96/185 (51%), Gaps = 12/185 (6%)
Query: 55 VTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKEKFKVETRTIAV------D 108
VTG++ GIG+ A +L+K G+ +VL +R +L++V E ++ + I V D
Sbjct: 55 VTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKEKDILVLPLDLTD 114
Query: 109 FASEDIYDKIKTGLAGLEIGILVNNVGMSYEYPEYFLDVPDLDNVIKKMININILSVCKM 168
S + K G I ILVNN GMS + L + +V +K+I +N L +
Sbjct: 115 TGSHEAATKAVLQEFG-RIDILVNNGGMS----QRSLCMDTSLDVYRKLIELNYLGTVSL 169
Query: 169 TQLVLPGMVERSKGAILNISSGSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRS-KGVFV 227
T+ VLP M+ER +G I+ ++S G++ VPL Y A+K + F L E + G+ V
Sbjct: 170 TKCVLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTELATYPGIIV 229
Query: 228 QSVLP 232
++ P
Sbjct: 230 SNICP 234
>gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
Length = 292
Score = 73.6 bits (179), Expect = 2e-13
Identities = 57/189 (30%), Positives = 97/189 (51%), Gaps = 17/189 (8%)
Query: 50 GEWAVVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKEKFKVETRTIA--- 106
G+ +VTG++ GIG+ A LAK G VV+ +RSK+ L +V S E IA
Sbjct: 34 GKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTM 93
Query: 107 --VDFASEDIYDKIKTGLAGLEIGIL--VNNVGMSYEYPEYFLDVPDLDNVIKKMININI 162
+ FA + + K + GL++ IL + N ++ + + + ++K + +N
Sbjct: 94 EDMTFAEQFVAQAGKL-MGGLDMLILNHITNTSLNLFHDDI--------HHVRKSMEVNF 144
Query: 163 LSVCKMTQLVLPGMVERSKGAILNISSGSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRS 222
LS +T LP M+++S G+I+ +SS +G + P++ YSA+K +D F + +EY
Sbjct: 145 LSYVVLTVAALP-MLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSV 203
Query: 223 KGVFVQSVL 231
V V L
Sbjct: 204 SRVNVSITL 212
>gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
Length = 292
Score = 73.6 bits (179), Expect = 2e-13
Identities = 57/189 (30%), Positives = 97/189 (51%), Gaps = 17/189 (8%)
Query: 50 GEWAVVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKEKFKVETRTIA--- 106
G+ +VTG++ GIG+ A LAK G VV+ +RSK+ L +V S E IA
Sbjct: 34 GKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTM 93
Query: 107 --VDFASEDIYDKIKTGLAGLEIGIL--VNNVGMSYEYPEYFLDVPDLDNVIKKMININI 162
+ FA + + K + GL++ IL + N ++ + + + ++K + +N
Sbjct: 94 EDMTFAEQFVAQAGKL-MGGLDMLILNHITNTSLNLFHDDI--------HHVRKSMEVNF 144
Query: 163 LSVCKMTQLVLPGMVERSKGAILNISSGSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRS 222
LS +T LP M+++S G+I+ +SS +G + P++ YSA+K +D F + +EY
Sbjct: 145 LSYVVLTVAALP-MLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSV 203
Query: 223 KGVFVQSVL 231
V V L
Sbjct: 204 SRVNVSITL 212
>gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo
sapiens]
Length = 278
Score = 72.8 bits (177), Expect = 4e-13
Identities = 59/217 (27%), Positives = 108/217 (49%), Gaps = 15/217 (6%)
Query: 35 RVWGVGNEAGVG-----PGLGEWAVVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQ 89
R W A G P + A+VT STDGIG + A LA+ G VV+ SR + +DQ
Sbjct: 12 RAWNSVRMASSGMTRRDPLANKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQ 71
Query: 90 VSSEIKEKFKVETRTIAVDFASEDIYDKIKTGL---AGLEIGILVNNVGMSYEYPEYFLD 146
+ ++ + T T+ +ED + T + G++I LV+N ++ +F
Sbjct: 72 AVATLQGEGLSVTGTVCHVGKAEDRERLVATAVKLHGGIDI--LVSNAAVN----PFFGS 125
Query: 147 VPDL-DNVIKKMININILSVCKMTQLVLPGMVERSKGAILNISSGSGMLPVPLLTIYSAT 205
+ D+ + V K ++IN+ + MT+ V+P M +R G+++ +SS + P P + Y+ +
Sbjct: 126 IMDVTEEVWDKTLDINVKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVS 185
Query: 206 KTFVDFFSQCLHEEYRSKGVFVQSVLPYFVATKLAKI 242
KT + ++ L E + + V + P + T +++
Sbjct: 186 KTALLGLTKTLAIELAPRNIRVNCLAPGLIKTSFSRM 222
>gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens]
Length = 260
Score = 70.5 bits (171), Expect = 2e-12
Identities = 60/209 (28%), Positives = 110/209 (52%), Gaps = 21/209 (10%)
Query: 47 PGLGEW----AVVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKEK-FKVE 101
PG+ W A+VTG++ GIG + A L + G+KVV +R+ ++++++E K +
Sbjct: 4 PGMERWRDRLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKSAGYPGT 63
Query: 102 TRTIAVDFASED----IYDKIKTGLAGLEIGILVNNVGMSYEYPEYFLDVPDLDNVIKKM 157
D ++E+ ++ I++ +G++ I +NN G++ P+ L + K M
Sbjct: 64 LIPYRCDLSNEEDILSMFSAIRSQHSGVD--ICINNAGLA--RPDTLLS--GSTSGWKDM 117
Query: 158 ININILSVCKMTQLVLPGMVERS--KGAILNISSGSG--MLPVPLLTIYSATKTFVDFFS 213
N+N+L++ T+ M ER+ G I+NI+S SG +LP+ + YSATK V +
Sbjct: 118 FNVNVLALSICTREAYQSMKERNVDDGHIININSMSGHRVLPLSVTHFYSATKYAVTALT 177
Query: 214 QCLHEEYRSKGVFVQS--VLPYFVATKLA 240
+ L +E R +++ + P V T+ A
Sbjct: 178 EGLRQELREAQTHIRATCISPGVVETQFA 206
>gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 1
[Homo sapiens]
Length = 266
Score = 70.1 bits (170), Expect = 2e-12
Identities = 61/200 (30%), Positives = 101/200 (50%), Gaps = 24/200 (12%)
Query: 50 GEWAVVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKEKFKVE-TRTIAVD 108
G+ A+VTG+ GIG+++AE L G KV L+ + + Q + + E+F+ + T I D
Sbjct: 5 GKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCD 64
Query: 109 FASE----DIYDKIKTGLAGLEIGILVNNVGMSYEYPEYFLDVPDLDNVIKKMININILS 164
A + D + K+ L+ ILVNN G++ E +K + IN++S
Sbjct: 65 VADQQQLRDTFRKVVDHFGRLD--ILVNNAGVNNE------------KNWEKTLQINLVS 110
Query: 165 VCKMTQLVLPGMVERS---KGAILNISSGSGMLPVPLLTIYSATKTFVDFF--SQCLHEE 219
V T L L M +++ G I+N+SS +G++PV +Y A+K + F S L
Sbjct: 111 VISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAAN 170
Query: 220 YRSKGVFVQSVLPYFVATKL 239
+ GV + ++ P FV T +
Sbjct: 171 LMNSGVRLNAICPGFVNTAI 190
>gi|44680136 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
sapiens]
Length = 343
Score = 69.7 bits (169), Expect = 3e-12
Identities = 60/194 (30%), Positives = 89/194 (45%), Gaps = 13/194 (6%)
Query: 54 VVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKEKFKVETRTIAVDFASED 113
+VTG G G S A+ L G V KDK E+ RT+ ++ S +
Sbjct: 59 LVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVCSSE 118
Query: 114 IYDKI----KTGLAGLEIGI--LVNNVGMSYEYPEYFLDVPDLDNVIKKMININILSVCK 167
+K+ ++ L E G+ LVNN G+S F + K++ +N+ +
Sbjct: 119 EVEKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSL----ETYKQVAEVNLWGTVR 174
Query: 168 MTQLVLPGMVERSKGAILNISSGSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRSKGVFV 227
MT+ LP ++ R+KG ++NISS G + P + Y TK V+ FS CL E GV V
Sbjct: 175 MTKSFLP-LIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKV 233
Query: 228 QSVLP--YFVATKL 239
V P + AT L
Sbjct: 234 SVVEPGNFIAATSL 247
>gi|44680133 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
sapiens]
Length = 343
Score = 69.7 bits (169), Expect = 3e-12
Identities = 60/194 (30%), Positives = 89/194 (45%), Gaps = 13/194 (6%)
Query: 54 VVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKEKFKVETRTIAVDFASED 113
+VTG G G S A+ L G V KDK E+ RT+ ++ S +
Sbjct: 59 LVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVCSSE 118
Query: 114 IYDKI----KTGLAGLEIGI--LVNNVGMSYEYPEYFLDVPDLDNVIKKMININILSVCK 167
+K+ ++ L E G+ LVNN G+S F + K++ +N+ +
Sbjct: 119 EVEKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSL----ETYKQVAEVNLWGTVR 174
Query: 168 MTQLVLPGMVERSKGAILNISSGSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRSKGVFV 227
MT+ LP ++ R+KG ++NISS G + P + Y TK V+ FS CL E GV V
Sbjct: 175 MTKSFLP-LIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKV 233
Query: 228 QSVLP--YFVATKL 239
V P + AT L
Sbjct: 234 SVVEPGNFIAATSL 247
>gi|17738292 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
sapiens]
Length = 343
Score = 69.7 bits (169), Expect = 3e-12
Identities = 60/194 (30%), Positives = 89/194 (45%), Gaps = 13/194 (6%)
Query: 54 VVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKEKFKVETRTIAVDFASED 113
+VTG G G S A+ L G V KDK E+ RT+ ++ S +
Sbjct: 59 LVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVCSSE 118
Query: 114 IYDKI----KTGLAGLEIGI--LVNNVGMSYEYPEYFLDVPDLDNVIKKMININILSVCK 167
+K+ ++ L E G+ LVNN G+S F + K++ +N+ +
Sbjct: 119 EVEKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSL----ETYKQVAEVNLWGTVR 174
Query: 168 MTQLVLPGMVERSKGAILNISSGSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRSKGVFV 227
MT+ LP ++ R+KG ++NISS G + P + Y TK V+ FS CL E GV V
Sbjct: 175 MTKSFLP-LIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKV 233
Query: 228 QSVLP--YFVATKL 239
V P + AT L
Sbjct: 234 SVVEPGNFIAATSL 247
>gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo
sapiens]
Length = 332
Score = 68.9 bits (167), Expect = 5e-12
Identities = 57/189 (30%), Positives = 93/189 (49%), Gaps = 10/189 (5%)
Query: 50 GEWAVVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKE---KFKVETRTIA 106
G VVTG + GIGK A E K G + L++R++DKL Q EI+ K I+
Sbjct: 32 GAHVVVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKEIEMHSINDKQVVLCIS 91
Query: 107 VDFASE--DIYDKIKTGLAGL-EIGILVNNVGMSYEYPEYFLDVPDLDNVIKKMININIL 163
VD + + + + IK L + +LVN GM+ L+V + +++++IN L
Sbjct: 92 VDVSQDYNQVENVIKQAQEKLGPVDMLVNCAGMAVSGKFEDLEV----STFERLMSINYL 147
Query: 164 SVCKMTQLVLPGMVERSKGAILNISSGSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRSK 223
++ V+ M ER G I+ +SS +G L + T YSA+K + ++ L E +
Sbjct: 148 GSVYPSRAVITTMKERRVGRIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEALQMEVKPY 207
Query: 224 GVFVQSVLP 232
V++ P
Sbjct: 208 NVYITVAYP 216
>gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A
[Homo sapiens]
Length = 300
Score = 68.9 bits (167), Expect = 5e-12
Identities = 59/199 (29%), Positives = 99/199 (49%), Gaps = 14/199 (7%)
Query: 50 GEWAVVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKEKFKVETRTIAVDF 109
GE ++TG+ GIG+ E AK +VL +K +++ ++E + K V VD
Sbjct: 36 GEIVLITGAGHGIGRQTTYEFAKRQSILVLWDINKRGVEETAAECR-KLGVTAHAYVVDC 94
Query: 110 AS-EDIY---DKIKTGLAGLEIGILVNNVGMSYEYPEYFLDVPDLDNVIKKMININILSV 165
++ E+IY +++K + ++ I+VNN G Y P L D + I K +NIL
Sbjct: 95 SNREEIYRSLNQVKKEVG--DVTIVVNNAGTVY--PADLLSTKDEE--ITKTFEVNILGH 148
Query: 166 CKMTQLVLPGMVERSKGAILNISSGSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRS--- 222
+T+ +LP M+ER+ G I+ ++S G +P L Y ++K F + L E ++
Sbjct: 149 FWITKALLPSMMERNHGHIVTVASVCGHEGIPYLIPYCSSKFAAVGFHRGLTSELQALGK 208
Query: 223 KGVFVQSVLPYFVATKLAK 241
G+ + P FV T K
Sbjct: 209 TGIKTSCLCPVFVNTGFTK 227
>gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo
sapiens]
Length = 280
Score = 66.2 bits (160), Expect = 3e-11
Identities = 55/193 (28%), Positives = 97/193 (50%), Gaps = 9/193 (4%)
Query: 53 AVVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIK-EKFKVETRTIAVDFAS 111
AVVTGST GIG + A LA+ G VV+ SR + +D+ ++++ E V V A
Sbjct: 39 AVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLSVAGIVCHVGKAE 98
Query: 112 --EDIYDKIKTGLAGLEIGILVNNVGMSYEYPEYFLDVPDLDNVIKKMININILSVCKMT 169
E + K G++ LV + G++ P + + + K++++N+ S +
Sbjct: 99 DREQLVAKALEHCGGVD--FLVCSAGVN---PLVGSTLGTSEQIWDKILSVNVKSPALLL 153
Query: 170 QLVLPGMVERSKGAILNISSGSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRSKGVFVQS 229
+LP M E +GA++ +SS + PV L +Y+ +KT + ++ L E K + V
Sbjct: 154 SQLLPYM-ENRRGAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALELAPKDIRVNC 212
Query: 230 VLPYFVATKLAKI 242
V+P + T +K+
Sbjct: 213 VVPGIIKTDFSKV 225
>gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo
sapiens]
Length = 300
Score = 66.2 bits (160), Expect = 3e-11
Identities = 55/193 (28%), Positives = 97/193 (50%), Gaps = 9/193 (4%)
Query: 53 AVVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIK-EKFKVETRTIAVDFAS 111
AVVTGST GIG + A LA+ G VV+ SR + +D+ ++++ E V V A
Sbjct: 39 AVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLSVAGIVCHVGKAE 98
Query: 112 --EDIYDKIKTGLAGLEIGILVNNVGMSYEYPEYFLDVPDLDNVIKKMININILSVCKMT 169
E + K G++ LV + G++ P + + + K++++N+ S +
Sbjct: 99 DREQLVAKALEHCGGVD--FLVCSAGVN---PLVGSTLGTSEQIWDKILSVNVKSPALLL 153
Query: 170 QLVLPGMVERSKGAILNISSGSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRSKGVFVQS 229
+LP M E +GA++ +SS + PV L +Y+ +KT + ++ L E K + V
Sbjct: 154 SQLLPYM-ENRRGAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALELAPKDIRVNC 212
Query: 230 VLPYFVATKLAKI 242
V+P + T +K+
Sbjct: 213 VVPGIIKTDFSKV 225
>gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens]
Length = 311
Score = 65.1 bits (157), Expect = 8e-11
Identities = 56/209 (26%), Positives = 94/209 (44%), Gaps = 13/209 (6%)
Query: 54 VVTGSTDGIGKSYAEELA---KHGMKVVLISRSKDKLDQVSSEIKEKFKVETRTIAVDFA 110
+++G + GIG A +LA K +VV R K + + + E +D
Sbjct: 9 LISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLGKKETLEAAAGEALGQTLTVAQLDVC 68
Query: 111 SEDIYDKIKTGLAGLEIGILVNNVGMSYEYPEYFLDVPDLDNVIKKMININILSVCKMTQ 170
S++ + + + G E+ +LVNN GM P L + + NV + N ++ +
Sbjct: 69 SDESVAQCLSCIQG-EVDVLVNNAGMGLVGPLEGLSLAAMQNVF----DTNFFGAVRLVK 123
Query: 171 LVLPGMVERSKGAILNISSGSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRSKGVFVQSV 230
VLPGM R +G I+ ISS G+ V +Y+A+K ++ F + L + +F+ V
Sbjct: 124 AVLPGMKRRRQGHIVVISSVMGLQGVIFNDVYAASKFALEGFFESLAIQLLQFNIFISLV 183
Query: 231 LPYFVATK-----LAKIRKPTLDKPSPET 254
P V T+ LA++ PET
Sbjct: 184 EPGPVVTEFEGKLLAQVSMAEFPGTDPET 212
>gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens]
Length = 309
Score = 63.9 bits (154), Expect = 2e-10
Identities = 49/195 (25%), Positives = 94/195 (48%), Gaps = 13/195 (6%)
Query: 50 GEWAVVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKEKFKVETRTIAVDF 109
GE ++TG+ G+G+ A + A+ G +VL +K+ ++ +E D
Sbjct: 40 GEIVLITGAGSGLGRLLALQFARLGSVLVLWDINKEGNEETCKMAREAGATRVHAYTCDC 99
Query: 110 ASED----IYDKIKTGLAGLEIGILVNNVGMSYEYPEYFLDVPDLDNVIKKMININILSV 165
+ ++ + D++K + ++ IL+NN G+ + FLD PD +++K ++N +
Sbjct: 100 SQKEGVYRVADQVKKEVG--DVSILINNAGIVTG--KKFLDCPD--ELMEKSFDVNFKAH 153
Query: 166 CKMTQLVLPGMVERSKGAILNISSGSGMLPVPLLTIYSATKTFVDFFSQCLHEE---YRS 222
+ LP M+ G ++ ISS +G+ V L Y A+K F++ + E +
Sbjct: 154 LWTYKAFLPAMIANDHGHLVCISSSAGLSGVNGLADYCASKFAAFGFAESVFVETFVQKQ 213
Query: 223 KGVFVQSVLPYFVAT 237
KG+ V P+F+ T
Sbjct: 214 KGIKTTIVCPFFIKT 228
>gi|224922801 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 2
[Homo sapiens]
Length = 178
Score = 63.5 bits (153), Expect = 2e-10
Identities = 52/165 (31%), Positives = 86/165 (52%), Gaps = 22/165 (13%)
Query: 50 GEWAVVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKEKFKVE-TRTIAVD 108
G+ A+VTG+ GIG+++AE L G KV L+ + + Q + + E+F+ + T I D
Sbjct: 5 GKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCD 64
Query: 109 FASE----DIYDKIKTGLAGLEIGILVNNVGMSYEYPEYFLDVPDLDNVIKKMININILS 164
A + D + K+ L+ ILVNN G++ E +K + IN++S
Sbjct: 65 VADQQQLRDTFRKVVDHFGRLD--ILVNNAGVNNE------------KNWEKTLQINLVS 110
Query: 165 VCKMTQLVLPGMVERS---KGAILNISSGSGMLPVPLLTIYSATK 206
V T L L M +++ G I+N+SS +G++PV +Y A+K
Sbjct: 111 VISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASK 155
>gi|7705925 dicarbonyl/L-xylulose reductase [Homo sapiens]
Length = 244
Score = 63.2 bits (152), Expect = 3e-10
Identities = 53/193 (27%), Positives = 96/193 (49%), Gaps = 12/193 (6%)
Query: 50 GEWAVVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKEKFKVETRTIAVDF 109
G +VTG+ GIG+ + L G +VV +SR++ LD S ++E +E + VD
Sbjct: 7 GRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLD---SLVRECPGIE--PVCVDL 61
Query: 110 ASEDIYDKIKTGLAGLEIGILVNNVGMSYEYPEYFLDVPDLDNVIKKMININILSVCKMT 169
+ ++ G G + +LVNN ++ P FL+V + +N+ +V +++
Sbjct: 62 GDWEATER-ALGSVG-PVDLLVNNAAVALLQP--FLEV--TKEAFDRSFEVNLRAVIQVS 115
Query: 170 QLVLPGMVERS-KGAILNISSGSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRSKGVFVQ 228
Q+V G++ R GAI+N+SS V ++Y +TK +D ++ + E + V
Sbjct: 116 QIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVN 175
Query: 229 SVLPYFVATKLAK 241
+V P V T + +
Sbjct: 176 AVNPTVVMTSMGQ 188
>gi|31543615 dehydrogenase/reductase (SDR family) member 3 [Homo
sapiens]
Length = 302
Score = 62.0 bits (149), Expect = 7e-10
Identities = 62/223 (27%), Positives = 102/223 (45%), Gaps = 13/223 (5%)
Query: 51 EWAVVTGSTDGIGKSYAEELAKHGM-KVVLISRSKDKLDQVSSEIKEKFKVETRTIAVDF 109
E ++TG GIG+ A E A+ G K+VL R++ L + + EI++ E D
Sbjct: 39 ENVLITGGGRGIGRQLAREFAERGARKIVLWGRTEKCLKETTEEIRQ-MGTECHYFICDV 97
Query: 110 AS-EDIYDKIKTGLAGL-EIGILVNNVGMSYEYPEYFLDVPDLDNVIKKMININILSVCK 167
+ E++Y K + +I ILVNN + + D D+ + K +IN L
Sbjct: 98 GNREEVYQTAKAVREKVGDITILVNNAAVVHGKSLMDSD----DDALLKSQHINTLGQFW 153
Query: 168 MTQLVLPGMVERSKGAILNISSGSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRS-KGVF 226
T+ LP M+E G I+ ++S + +P Y +K F + L GV
Sbjct: 154 TTKAFLPRMLELQNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESLTLGLLDCPGVS 213
Query: 227 VQSVLPYFVATKL---AKIRKPTLDKP-SPETFVKSAIKTVGL 265
+VLP+ +T++ ++R P L P PET + ++ V L
Sbjct: 214 ATTVLPFHTSTEMFQGMRVRFPNLFPPLKPETVARRTVEAVQL 256
>gi|126723191 dehydrogenase/reductase (SDR family) member 4 like 2
[Homo sapiens]
Length = 232
Score = 61.6 bits (148), Expect = 9e-10
Identities = 48/158 (30%), Positives = 85/158 (53%), Gaps = 8/158 (5%)
Query: 53 AVVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKEKFKVETRTIAVDFASE 112
A+VT STDGIG + A LA+ VV+ SR + +DQ + ++ + T T+ +E
Sbjct: 35 ALVTASTDGIGFAIARRLAQDRAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVCHVGKAE 94
Query: 113 DIYDKIKTGLAGLE--IGILVNNVGMSYEYPEYFLDVPDL-DNVIKKMININILSVCKMT 169
D +++ L I ILV+N ++ +F + D+ + V K ++IN+ + MT
Sbjct: 95 D-RERLVAMAVKLHGGIDILVSNAAVN----PFFGSLMDVTEEVWDKTLDINVKAPALMT 149
Query: 170 QLVLPGMVERSKGAILNISSGSGMLPVPLLTIYSATKT 207
+ V+P M +R G+++ +SS + P P + Y+ +KT
Sbjct: 150 KAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKT 187
>gi|157739938 dehydrogenase/reductase (SDR family) member 7C [Homo
sapiens]
Length = 311
Score = 61.2 bits (147), Expect = 1e-09
Identities = 44/188 (23%), Positives = 88/188 (46%), Gaps = 10/188 (5%)
Query: 54 VVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSS---EIKEKFKVET-RTIAVDF 109
V+T + G+GK A G ++VL ++ ++L+ + + + K T + + +D
Sbjct: 41 VITDAISGLGKECARVFHTGGARLVLCGKNWERLENLYDALISVADPSKTFTPKLVLLDL 100
Query: 110 ASEDIYDKIKTGLAGLE--IGILVNNVGMSYEYPEYFLDVPDLDNVIKKMININILSVCK 167
+ + + + IL+NN + + P + + + +LD KK+++ N
Sbjct: 101 SDISCVPDVAKEVLDCYGCVDILINNASVKVKGPAHKISL-ELD---KKIMDANYFGPIT 156
Query: 168 MTQLVLPGMVERSKGAILNISSGSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRSKGVFV 227
+T+ +LP M+ R G I+ +++ G +P T Y+A+K F CL E V +
Sbjct: 157 LTKALLPNMISRRTGQIVLVNNIQGKFGIPFRTTYAASKHAALGFFDCLRAEVEEYDVVI 216
Query: 228 QSVLPYFV 235
+V P F+
Sbjct: 217 STVSPTFI 224
>gi|150247226 retinol dehydrogenase 16 [Homo sapiens]
Length = 317
Score = 59.3 bits (142), Expect = 4e-09
Identities = 65/221 (29%), Positives = 103/221 (46%), Gaps = 35/221 (15%)
Query: 51 EWAVVTGSTDGIGKSYAEELAKHGMKVV-----------LISRSKDKLDQVSSEIKEKFK 99
++ +TG G GK A +L G++V+ L ++ D+L+ V+ ++ K
Sbjct: 30 KYVFITGCDSGFGKLLARQLDARGLRVLAACLTEKGAEQLRGQTSDRLETVTLDVT---K 86
Query: 100 VETRTIAVDFASEDIYDKIKTGLAGLEIGILVNNVGMSY-EYPEYFLDVPDLDNVIKKMI 158
E+ A + E + DK GL G LVNN G+S P L D + +
Sbjct: 87 TESVAAAAQWVKECVRDK---GLWG-----LVNNAGISLPTAPNELLTKQDFVTI----L 134
Query: 159 NINILSVCKMTQLVLPGMVERSKGAILNISSGSGMLPVPLLTIYSATKTFVDFFSQCLHE 218
++N+L V +T +LP +V R++G ++N+SS G + + Y +K V+ FS L
Sbjct: 135 DVNLLGVIDVTLSLLP-LVRRARGRVVNVSSVMGRVSL-FGGGYCISKYGVEAFSDSLRR 192
Query: 219 EYRSKGVFVQSVLP-YFVATKLAKIR--KPTL---DKPSPE 253
E GV V + P YF +K R K L D+ SPE
Sbjct: 193 ELSYFGVKVAMIEPGYFKTAVTSKERFLKSFLEIWDRSSPE 233
>gi|4504503 hydroxysteroid (17-beta) dehydrogenase 2 [Homo sapiens]
Length = 387
Score = 57.4 bits (137), Expect = 2e-08
Identities = 49/205 (23%), Positives = 90/205 (43%), Gaps = 15/205 (7%)
Query: 54 VVTGSTDGIGKSYAEELAKHGMKVV--LISRSKDKLDQVSSEIKEKFKVETRTIAVDFAS 111
+VTG G+G + + L + G V +++ + +++ + V I
Sbjct: 86 LVTGGDCGLGHALCKYLDELGFTVFAGVLNENGPGAEELRRTCSPRLSVLQMDITKPVQI 145
Query: 112 EDIYDKIKTGLAGLEIGILVNNVG-MSYEYPEYFLDVPDLDNVIKKMININILSVCKMTQ 170
+D Y K+ L + ++NN G + + L + D K+ + +N ++T+
Sbjct: 146 KDAYSKVAAMLQDRGLWAVINNAGVLGFPTDGELLLMTDY----KQCMAVNFFGTVEVTK 201
Query: 171 LVLPGMVERSKGAILNISSGSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRSKGVFVQSV 230
LP ++ +SKG ++N+SS G P+ L Y ++K V FS + E G+ V S+
Sbjct: 202 TFLP-LLRKSKGRLVNVSSMGGGAPMERLASYGSSKAAVTMFSSVMRLELSKWGIKVASI 260
Query: 231 LPYFVATKLA-------KIRKPTLD 248
P T +A K+ K LD
Sbjct: 261 QPGGFLTNIAGTSDKWEKLEKDILD 285
>gi|22507405 short chain dehydrogenase/reductase family 9C, member 7
[Homo sapiens]
Length = 313
Score = 57.4 bits (137), Expect = 2e-08
Identities = 50/187 (26%), Positives = 95/187 (50%), Gaps = 15/187 (8%)
Query: 51 EWAVVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKEKFKVE----TRTIA 106
++ +TG G G A++L GM+V+ +++ ++ + + + T++ +
Sbjct: 26 KYVFITGCDSGFGNLLAKQLVDRGMQVLAACFTEEGSQKLQRDTSYRLQTTLLDVTKSES 85
Query: 107 VDFASEDIYDKIKTGLAGLEIGILVNNVGMSY-EYPEYFLDVPDLDNVIKKMININILSV 165
+ A++ + DK+ G GL LVNN G+ P +L D K+IN+N++ +
Sbjct: 86 IKAAAQWVRDKV--GEQGL--WALVNNAGVGLPSGPNEWLTKDD----FVKVINVNLVGL 137
Query: 166 CKMTQLVLPGMVERSKGAILNISSGSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRSKGV 225
++T +LP MV+R++G ++N+SS G + V + Y +K V+ FS + E GV
Sbjct: 138 IEVTLHMLP-MVKRARGRVVNMSSSGGRVAV-IGGGYCVSKFGVEAFSDSIRRELYYFGV 195
Query: 226 FVQSVLP 232
V + P
Sbjct: 196 KVCIIEP 202
>gi|19743808 hydroxysteroid (17-beta) dehydrogenase 6 [Homo sapiens]
Length = 317
Score = 56.2 bits (134), Expect = 4e-08
Identities = 54/204 (26%), Positives = 98/204 (48%), Gaps = 29/204 (14%)
Query: 51 EWAVVTGSTDGIGKSYAEELAKHGMKVV-----------LISRSKDKLDQVSSEIKEKFK 99
++ +TG G G A +L G++V+ L ++ D+L+ V+ ++ K
Sbjct: 30 KYVFITGCDSGFGNLLARQLDARGLRVLAACLTEKGAEQLRGQTSDRLETVTLDVT---K 86
Query: 100 VETRTIAVDFASEDIYDKIKTGLAGLEIGILVNNVGMSYEYPE-YFLDVPDLDNVIKKMI 158
+E+ A + E + D+ GL G LVNN G+ +L+ D N++K
Sbjct: 87 MESIAAATQWVKEHVGDR---GLWG-----LVNNAGILTPITLCEWLNTEDSMNMLK--- 135
Query: 159 NINILSVCKMTQLVLPGMVERSKGAILNISSGSGMLPVPLLTIYSATKTFVDFFSQCLHE 218
+N++ V ++T +LP +V R++G I+N+SS G + + Y +K V+ FS L
Sbjct: 136 -VNLIGVIQVTLSMLP-LVRRARGRIVNVSSILGRVAF-FVGGYCVSKYGVEAFSDILRR 192
Query: 219 EYRSKGVFVQSVLPYFVATKLAKI 242
E + GV + V P + T + +
Sbjct: 193 EIQHFGVKISIVEPGYFRTGMTNM 216
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.135 0.388
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,544,714
Number of Sequences: 37866
Number of extensions: 435222
Number of successful extensions: 1246
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 52
Number of HSP's successfully gapped in prelim test: 21
Number of HSP's that attempted gapping in prelim test: 1143
Number of HSP's gapped (non-prelim): 76
length of query: 312
length of database: 18,247,518
effective HSP length: 102
effective length of query: 210
effective length of database: 14,385,186
effective search space: 3020889060
effective search space used: 3020889060
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.