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Search of human proteins with 7662160
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7662160 hypothetical protein LOC9813 [Homo sapiens]
(495 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7662160 hypothetical protein LOC9813 [Homo sapiens] 962 0.0
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 55 1e-07
gi|205277396 dynactin 1 isoform 4 [Homo sapiens] 54 4e-07
gi|205277392 dynactin 1 isoform 3 [Homo sapiens] 54 4e-07
gi|13259508 dynactin 1 isoform 2 [Homo sapiens] 54 4e-07
gi|13259510 dynactin 1 isoform 1 [Homo sapiens] 54 4e-07
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 53 7e-07
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 52 2e-06
gi|38044112 restin isoform b [Homo sapiens] 50 6e-06
gi|4506751 restin isoform a [Homo sapiens] 50 6e-06
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 49 8e-06
gi|33946313 ninein isoform 4 [Homo sapiens] 49 1e-05
gi|33946321 ninein isoform 5 [Homo sapiens] 49 1e-05
gi|148536871 ninein isoform 1 [Homo sapiens] 49 1e-05
gi|148536869 ninein isoform 2 [Homo sapiens] 49 1e-05
gi|63252900 tropomyosin 1 alpha chain isoform 4 [Homo sapiens] 48 2e-05
gi|112420968 coiled-coil domain containing 158 [Homo sapiens] 48 2e-05
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 48 2e-05
gi|50083279 centrosome protein 4 [Homo sapiens] 48 2e-05
gi|27597085 tropomyosin 1 alpha chain isoform 5 [Homo sapiens] 47 3e-05
gi|109659847 filamin A interacting protein 1-like isoform 3 [Hom... 47 3e-05
gi|109659849 filamin A interacting protein 1-like isoform 2 [Hom... 47 3e-05
gi|109659845 filamin A interacting protein 1-like isoform 1 [Hom... 47 3e-05
gi|237858621 polyamine modulated factor 1 binding protein 1 isof... 47 4e-05
gi|187761324 shootin1 isoform a [Homo sapiens] 47 5e-05
gi|148762940 DVL-binding protein DAPLE [Homo sapiens] 47 5e-05
gi|63252906 tropomyosin 1 alpha chain isoform 7 [Homo sapiens] 46 9e-05
gi|70166430 GRINL1A combined protein isoform 2 [Homo sapiens] 45 2e-04
gi|70166414 GRINL1A combined protein isoform 1 [Homo sapiens] 45 2e-04
gi|70166580 GRINL1A upstream protein isoform 7 [Homo sapiens] 45 2e-04
>gi|7662160 hypothetical protein LOC9813 [Homo sapiens]
Length = 495
Score = 962 bits (2487), Expect = 0.0
Identities = 495/495 (100%), Positives = 495/495 (100%)
Query: 1 MKKRKELNALIGLAGDSRRKKPKKGPSSHRLLRTEPPDSDSESSSEEEEEFGVVGNRSRF 60
MKKRKELNALIGLAGDSRRKKPKKGPSSHRLLRTEPPDSDSESSSEEEEEFGVVGNRSRF
Sbjct: 1 MKKRKELNALIGLAGDSRRKKPKKGPSSHRLLRTEPPDSDSESSSEEEEEFGVVGNRSRF 60
Query: 61 AKGDYLRCCKICYPLCGFVILAACVVACVGLVWMQVALKEDLDALKEKFRTMESNQKSSF 120
AKGDYLRCCKICYPLCGFVILAACVVACVGLVWMQVALKEDLDALKEKFRTMESNQKSSF
Sbjct: 61 AKGDYLRCCKICYPLCGFVILAACVVACVGLVWMQVALKEDLDALKEKFRTMESNQKSSF 120
Query: 121 QEIPKLNEELLSKQKQLEKIESGEMGLNKVWINITEMNKQISLLTSAVNHLKANVKSAAD 180
QEIPKLNEELLSKQKQLEKIESGEMGLNKVWINITEMNKQISLLTSAVNHLKANVKSAAD
Sbjct: 121 QEIPKLNEELLSKQKQLEKIESGEMGLNKVWINITEMNKQISLLTSAVNHLKANVKSAAD 180
Query: 181 LISLPTTVEGLQKSVASIGNTLNSVHLAVEALQKTVDEHKKTMELLQSDMNQHFLKETPG 240
LISLPTTVEGLQKSVASIGNTLNSVHLAVEALQKTVDEHKKTMELLQSDMNQHFLKETPG
Sbjct: 181 LISLPTTVEGLQKSVASIGNTLNSVHLAVEALQKTVDEHKKTMELLQSDMNQHFLKETPG 240
Query: 241 SNQIIPSPSATSELDNKTHSENLKQDILYLHNSLEEVNSALVGYQRQNDLKLEGMNETVS 300
SNQIIPSPSATSELDNKTHSENLKQDILYLHNSLEEVNSALVGYQRQNDLKLEGMNETVS
Sbjct: 241 SNQIIPSPSATSELDNKTHSENLKQDILYLHNSLEEVNSALVGYQRQNDLKLEGMNETVS 300
Query: 301 NLTQRVNLIESDVVAMSKVEKKANLSFSMMGDRSATLKRQSLDQVTNRTDTVKIQSIKKE 360
NLTQRVNLIESDVVAMSKVEKKANLSFSMMGDRSATLKRQSLDQVTNRTDTVKIQSIKKE
Sbjct: 301 NLTQRVNLIESDVVAMSKVEKKANLSFSMMGDRSATLKRQSLDQVTNRTDTVKIQSIKKE 360
Query: 361 DSSNSQVSKLREKLQLISALTNKPESNRPPETADEEQVESFTSKPSALPKFSQFLGDPVE 420
DSSNSQVSKLREKLQLISALTNKPESNRPPETADEEQVESFTSKPSALPKFSQFLGDPVE
Sbjct: 361 DSSNSQVSKLREKLQLISALTNKPESNRPPETADEEQVESFTSKPSALPKFSQFLGDPVE 420
Query: 421 KAAQLRPISLPGVSSTEDLQDLFRKTGQDVDGKLTYQEIWTSLGSAMPEPESLRAFDSDG 480
KAAQLRPISLPGVSSTEDLQDLFRKTGQDVDGKLTYQEIWTSLGSAMPEPESLRAFDSDG
Sbjct: 421 KAAQLRPISLPGVSSTEDLQDLFRKTGQDVDGKLTYQEIWTSLGSAMPEPESLRAFDSDG 480
Query: 481 DGRYSFLELRVALGI 495
DGRYSFLELRVALGI
Sbjct: 481 DGRYSFLELRVALGI 495
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 55.5 bits (132), Expect = 1e-07
Identities = 67/324 (20%), Positives = 134/324 (41%), Gaps = 55/324 (16%)
Query: 98 LKEDLDALKEKFRTMESNQKSSFQEIPKLNEELLSKQKQLEKIESGEMGLNKVWINITEM 157
LK+ LD+ K +ES +K + Q L+EE L ++ +E ++ M + ++ + E+
Sbjct: 675 LKKTLDSFKNLTFQLESLEKENSQ----LDEENLELRRNVESLKCASMKMAQLQLENKEL 730
Query: 158 NKQISLLTSAVNHLKANVKSAADLI-----------SLPTTVEGLQKSVASIGNTLNSVH 206
+ L + LKA+ K L L T+E K + + + L +
Sbjct: 731 ESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLE 790
Query: 207 LAVEALQKTVDEHKKTMELLQSDMNQHFLKETPGSNQIIPSPSATSELDNK---THSENL 263
+ + LQK ++E K ++ L++ N+ + ++ E D K ++ L
Sbjct: 791 MENQTLQKNLEELK---------ISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRL 841
Query: 264 KQDILYLHNSLEEVNSALVGYQRQNDLKLEGMNETVSNLTQRVNLIESDVVAMSKVEKKA 323
+Q +LEE N++K+ + + L++ + + + V + ++EK
Sbjct: 842 RQQAEIKDTTLEE-----------NNVKIGNLEKENKTLSKEIGIYKESCVRLKELEK-- 888
Query: 324 NLSFSMMGDRSATLKRQSLD---QVTNRTDTVKIQSIKKEDSSNSQVSKLREKLQLISAL 380
+ +KR ++D VT R D V + K N+ + KL +L+ I
Sbjct: 889 --------ENKELVKRATIDIKTLVTLREDLVSEK--LKTQQMNNDLEKLTHELEKIG-- 936
Query: 381 TNKPESNRPPETADEEQVESFTSK 404
NK ++ D+ + + SK
Sbjct: 937 LNKERLLHDEQSTDDSRYKLLESK 960
Score = 45.1 bits (105), Expect = 2e-04
Identities = 62/293 (21%), Positives = 132/293 (45%), Gaps = 24/293 (8%)
Query: 98 LKEDLDALKEKFR-TMESNQKSSFQEIPKLNEELLSKQKQLEKIESGEMGLNKVWINITE 156
L + + +L+++ + + E+ K +E L+E + +L KIE + + K + E
Sbjct: 563 LNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKE 622
Query: 157 MNKQISLLTSAVNHL-KANVKSAADLISLPTTVEGLQKSVASIGNTLNSVHLAVEALQKT 215
++ L + ++HL K N + +L T E + ++ + + L+KT
Sbjct: 623 KGERAEELENELHHLEKENELLQKKITNLKITCE----KIEALEQENSELERENRKLKKT 678
Query: 216 VDEHKKTMELLQS--------DMNQHFLKETPGSNQIIPSPSATSELDNK---THSENLK 264
+D K L+S D L+ S + A +L+NK + E LK
Sbjct: 679 LDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLK 738
Query: 265 QDILYLHNSLEEVNSALVGYQRQNDLKLEGMNETVSNLTQRVNLIESDV--VAMSKVEKK 322
+ + L S ++ V YQ D++ + + +T+ N +++ +ES++ + M +
Sbjct: 739 KGLELLKASFKKTERLEVSYQGL-DIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQ 797
Query: 323 ANL-SFSMMGDRSATLKRQ--SLDQVTNRTDTVKIQSIKKEDSSNSQVSKLRE 372
NL + R L+++ SL+Q T++ + K Q ++KE+ Q +++++
Sbjct: 798 KNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQ-LEKENKRLRQQAEIKD 849
Score = 34.3 bits (77), Expect = 0.27
Identities = 47/254 (18%), Positives = 107/254 (42%), Gaps = 27/254 (10%)
Query: 98 LKEDLDALKEKFRTMESNQKSSFQEIPKLNEELLSKQK-------QLEKIESGEMGLNKV 150
L+ + ALK + + +E+ + +I L + +S Q+ Q K++ LN
Sbjct: 1058 LQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQ 1117
Query: 151 WINITEMNKQISLLTSAV-NHLKANVKSAADLISLPTTVEGLQKSVASIGNTLNSVHLAV 209
++ N Q+ + S++ N ++ +K DL SL ++ + + + S + ++
Sbjct: 1118 STSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESL 1177
Query: 210 EALQKTVDEHKKTMELLQSDMNQHFLKETPGSNQIIPSPSATSELDNKTHSENLKQDILY 269
+ T+ K +E+ D+ + NQ++ +L+ ++Q+ +
Sbjct: 1178 ISKHGTLKSAHKNLEVEHRDLEDRY-------NQLLKQKGQLEDLEKML---KVEQEKML 1227
Query: 270 LHNSLEEVNSALVGYQR---QNDLKLEGMNETVSNLTQRVNLIESDVVAMSKVEKKANLS 326
L N E +A Y++ +ND +N T S L + ++++D + + + L
Sbjct: 1228 LENKNHETVAA--EYKKLCGEND----RLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLE 1281
Query: 327 FSMMGDRSATLKRQ 340
+ + + LK Q
Sbjct: 1282 QTRLEAEFSKLKEQ 1295
>gi|205277396 dynactin 1 isoform 4 [Homo sapiens]
Length = 1139
Score = 53.5 bits (127), Expect = 4e-07
Identities = 62/300 (20%), Positives = 123/300 (41%), Gaps = 22/300 (7%)
Query: 101 DLDALKEKFRTMESNQKSSFQEIPKLNEELLSKQKQLEKIESGEMGLNKVWINITEMNKQ 160
DL+ E R + K+ +E+ K +L Q+ K++ + L + + E K+
Sbjct: 92 DLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQR---RLKEARKE 148
Query: 161 ISLLTSAVNHLKANVKSAADLISLPTTVEGLQKSVASIGNTLNSVHLAVEALQKTVDEHK 220
A + AD I + T L K +A S+ VEAL++ VDE
Sbjct: 149 AKEALEAKERYMEEMADTADAIEMAT----LDKEMAE--ERAESLQQEVEALKERVDELT 202
Query: 221 KTMELLQSDMNQHFLKETPGSNQIIPSPSATSELDN-----KTHSENLKQDILYLHNSLE 275
+E+L++++ + S Q+ + L + + S + KQ+ + L +E
Sbjct: 203 TDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLME 262
Query: 276 EVNSALVGYQRQNDLKLEGMNETVSNLTQRVNLIESDVVAMSKVEKKANLSFSMMGDRSA 335
+ N L ++Q + E +++ S + + +++ + A VE M+ DR+
Sbjct: 263 KKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVE--------MLTDRNL 314
Query: 336 TLKRQSLDQVTNRTDTVKIQSIKKEDSSNSQVSKLREKLQLISALTNKPESNRPPETADE 395
L+ + + D + + E N++ ++L + QL A E+ + E A E
Sbjct: 315 NLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQE 374
>gi|205277392 dynactin 1 isoform 3 [Homo sapiens]
Length = 1253
Score = 53.5 bits (127), Expect = 4e-07
Identities = 62/300 (20%), Positives = 123/300 (41%), Gaps = 22/300 (7%)
Query: 101 DLDALKEKFRTMESNQKSSFQEIPKLNEELLSKQKQLEKIESGEMGLNKVWINITEMNKQ 160
DL+ E R + K+ +E+ K +L Q+ K++ + L + + E K+
Sbjct: 206 DLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQR---RLKEARKE 262
Query: 161 ISLLTSAVNHLKANVKSAADLISLPTTVEGLQKSVASIGNTLNSVHLAVEALQKTVDEHK 220
A + AD I + T L K +A S+ VEAL++ VDE
Sbjct: 263 AKEALEAKERYMEEMADTADAIEMAT----LDKEMAE--ERAESLQQEVEALKERVDELT 316
Query: 221 KTMELLQSDMNQHFLKETPGSNQIIPSPSATSELDN-----KTHSENLKQDILYLHNSLE 275
+E+L++++ + S Q+ + L + + S + KQ+ + L +E
Sbjct: 317 TDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLME 376
Query: 276 EVNSALVGYQRQNDLKLEGMNETVSNLTQRVNLIESDVVAMSKVEKKANLSFSMMGDRSA 335
+ N L ++Q + E +++ S + + +++ + A VE M+ DR+
Sbjct: 377 KKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVE--------MLTDRNL 428
Query: 336 TLKRQSLDQVTNRTDTVKIQSIKKEDSSNSQVSKLREKLQLISALTNKPESNRPPETADE 395
L+ + + D + + E N++ ++L + QL A E+ + E A E
Sbjct: 429 NLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQE 488
>gi|13259508 dynactin 1 isoform 2 [Homo sapiens]
Length = 1144
Score = 53.5 bits (127), Expect = 4e-07
Identities = 62/300 (20%), Positives = 123/300 (41%), Gaps = 22/300 (7%)
Query: 101 DLDALKEKFRTMESNQKSSFQEIPKLNEELLSKQKQLEKIESGEMGLNKVWINITEMNKQ 160
DL+ E R + K+ +E+ K +L Q+ K++ + L + + E K+
Sbjct: 92 DLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQR---RLKEARKE 148
Query: 161 ISLLTSAVNHLKANVKSAADLISLPTTVEGLQKSVASIGNTLNSVHLAVEALQKTVDEHK 220
A + AD I + T L K +A S+ VEAL++ VDE
Sbjct: 149 AKEALEAKERYMEEMADTADAIEMAT----LDKEMAE--ERAESLQQEVEALKERVDELT 202
Query: 221 KTMELLQSDMNQHFLKETPGSNQIIPSPSATSELDN-----KTHSENLKQDILYLHNSLE 275
+E+L++++ + S Q+ + L + + S + KQ+ + L +E
Sbjct: 203 TDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLME 262
Query: 276 EVNSALVGYQRQNDLKLEGMNETVSNLTQRVNLIESDVVAMSKVEKKANLSFSMMGDRSA 335
+ N L ++Q + E +++ S + + +++ + A VE M+ DR+
Sbjct: 263 KKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVE--------MLTDRNL 314
Query: 336 TLKRQSLDQVTNRTDTVKIQSIKKEDSSNSQVSKLREKLQLISALTNKPESNRPPETADE 395
L+ + + D + + E N++ ++L + QL A E+ + E A E
Sbjct: 315 NLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQE 374
>gi|13259510 dynactin 1 isoform 1 [Homo sapiens]
Length = 1278
Score = 53.5 bits (127), Expect = 4e-07
Identities = 62/300 (20%), Positives = 123/300 (41%), Gaps = 22/300 (7%)
Query: 101 DLDALKEKFRTMESNQKSSFQEIPKLNEELLSKQKQLEKIESGEMGLNKVWINITEMNKQ 160
DL+ E R + K+ +E+ K +L Q+ K++ + L + + E K+
Sbjct: 226 DLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQR---RLKEARKE 282
Query: 161 ISLLTSAVNHLKANVKSAADLISLPTTVEGLQKSVASIGNTLNSVHLAVEALQKTVDEHK 220
A + AD I + T L K +A S+ VEAL++ VDE
Sbjct: 283 AKEALEAKERYMEEMADTADAIEMAT----LDKEMAE--ERAESLQQEVEALKERVDELT 336
Query: 221 KTMELLQSDMNQHFLKETPGSNQIIPSPSATSELDN-----KTHSENLKQDILYLHNSLE 275
+E+L++++ + S Q+ + L + + S + KQ+ + L +E
Sbjct: 337 TDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLME 396
Query: 276 EVNSALVGYQRQNDLKLEGMNETVSNLTQRVNLIESDVVAMSKVEKKANLSFSMMGDRSA 335
+ N L ++Q + E +++ S + + +++ + A VE M+ DR+
Sbjct: 397 KKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVE--------MLTDRNL 448
Query: 336 TLKRQSLDQVTNRTDTVKIQSIKKEDSSNSQVSKLREKLQLISALTNKPESNRPPETADE 395
L+ + + D + + E N++ ++L + QL A E+ + E A E
Sbjct: 449 NLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQE 508
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 52.8 bits (125), Expect = 7e-07
Identities = 62/297 (20%), Positives = 124/297 (41%), Gaps = 53/297 (17%)
Query: 98 LKEDLDALKEKFRTMESNQKSSFQEIPKLNEELLSKQKQLEKIESGEMGLNKVWINITEM 157
LK+ LD+ K +ES +K + Q L+EE L ++ +E ++ M + ++ + E+
Sbjct: 675 LKKTLDSFKNLTFQLESLEKENSQ----LDEENLELRRNVESLKCASMKMAQLQLENKEL 730
Query: 158 NKQISLLTSAVNHLKANVKSAADLI-----------SLPTTVEGLQKSVASIGNTLNSVH 206
+ L + LKA+ K L L T+E K + + + L +
Sbjct: 731 ESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLE 790
Query: 207 LAVEALQKTVDEHKKTMELLQSDMNQHFLKETPGSNQIIPSPSATSELDNK---THSENL 263
+ + LQK ++E K ++ L++ N+ + ++ E D K ++ L
Sbjct: 791 MENQTLQKNLEELK---------ISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRL 841
Query: 264 KQDILYLHNSLEEVNSALVGYQRQNDLKLEGMNETVSNLTQRVNLIESDVVAMSKVEKKA 323
+Q +LEE N++K+ + + L++ + + + V + ++EK
Sbjct: 842 RQQAEIKDTTLEE-----------NNVKIGNLEKENKTLSKEIGIYKESCVRLKELEK-- 888
Query: 324 NLSFSMMGDRSATLKRQSLD---QVTNRTDTVKIQSIKKEDSSNSQVSKLREKLQLI 377
+ +KR ++D VT R D V + K N+ + KL +L+ I
Sbjct: 889 --------ENKELVKRATIDIKTLVTLREDLVSEK--LKTQQMNNDLEKLTHELEKI 935
Score = 45.1 bits (105), Expect = 2e-04
Identities = 62/293 (21%), Positives = 132/293 (45%), Gaps = 24/293 (8%)
Query: 98 LKEDLDALKEKFR-TMESNQKSSFQEIPKLNEELLSKQKQLEKIESGEMGLNKVWINITE 156
L + + +L+++ + + E+ K +E L+E + +L KIE + + K + E
Sbjct: 563 LNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKE 622
Query: 157 MNKQISLLTSAVNHL-KANVKSAADLISLPTTVEGLQKSVASIGNTLNSVHLAVEALQKT 215
++ L + ++HL K N + +L T E + ++ + + L+KT
Sbjct: 623 KGERAEELENELHHLEKENELLQKKITNLKITCE----KIEALEQENSELERENRKLKKT 678
Query: 216 VDEHKKTMELLQS--------DMNQHFLKETPGSNQIIPSPSATSELDNK---THSENLK 264
+D K L+S D L+ S + A +L+NK + E LK
Sbjct: 679 LDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLK 738
Query: 265 QDILYLHNSLEEVNSALVGYQRQNDLKLEGMNETVSNLTQRVNLIESDV--VAMSKVEKK 322
+ + L S ++ V YQ D++ + + +T+ N +++ +ES++ + M +
Sbjct: 739 KGLELLKASFKKTERLEVSYQGL-DIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQ 797
Query: 323 ANL-SFSMMGDRSATLKRQ--SLDQVTNRTDTVKIQSIKKEDSSNSQVSKLRE 372
NL + R L+++ SL+Q T++ + K Q ++KE+ Q +++++
Sbjct: 798 KNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQ-LEKENKRLRQQAEIKD 849
Score = 34.3 bits (77), Expect = 0.27
Identities = 47/254 (18%), Positives = 107/254 (42%), Gaps = 27/254 (10%)
Query: 98 LKEDLDALKEKFRTMESNQKSSFQEIPKLNEELLSKQK-------QLEKIESGEMGLNKV 150
L+ + ALK + + +E+ + +I L + +S Q+ Q K++ LN
Sbjct: 1057 LQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQ 1116
Query: 151 WINITEMNKQISLLTSAV-NHLKANVKSAADLISLPTTVEGLQKSVASIGNTLNSVHLAV 209
++ N Q+ + S++ N ++ +K DL SL ++ + + + S + ++
Sbjct: 1117 STSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESL 1176
Query: 210 EALQKTVDEHKKTMELLQSDMNQHFLKETPGSNQIIPSPSATSELDNKTHSENLKQDILY 269
+ T+ K +E+ D+ + NQ++ +L+ ++Q+ +
Sbjct: 1177 ISKHGTLKSAHKNLEVEHRDLEDRY-------NQLLKQKGQLEDLEKML---KVEQEKML 1226
Query: 270 LHNSLEEVNSALVGYQR---QNDLKLEGMNETVSNLTQRVNLIESDVVAMSKVEKKANLS 326
L N E +A Y++ +ND +N T S L + ++++D + + + L
Sbjct: 1227 LENKNHETVAA--EYKKLCGEND----RLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLE 1280
Query: 327 FSMMGDRSATLKRQ 340
+ + + LK Q
Sbjct: 1281 QTRLEAEFSKLKEQ 1294
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 51.6 bits (122), Expect = 2e-06
Identities = 65/342 (19%), Positives = 149/342 (43%), Gaps = 50/342 (14%)
Query: 99 KEDLDALKEKFRTMESNQKSSFQEIPKLNEELLSKQKQLEKIESGEMGLNKVWINITEMN 158
++ L K E N K + KL + Q++L+++ ++ L+ +I+ M
Sbjct: 1800 EKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHN---DISAMQ 1856
Query: 159 KQISLLTSAVNHLKANVKSAADLISLP---------------TTVEGLQKSVASIGNTLN 203
+Q+ AVN L+ + + D ++L + LQK ++ N
Sbjct: 1857 QQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFE 1916
Query: 204 SVHLAVEA-------LQKTVDEHKKTMELLQSDMNQHFLKETPGSNQIIPSPSATSELDN 256
E LQ ++E+K ++L+Q +M L++ S + S TS++
Sbjct: 1917 DCQKEEETKQQQLQVLQNEIEENK--LKLVQQEMMFQRLQKERESEE---SKLETSKVTL 1971
Query: 257 KTHSENLKQDILYLHNSLEEVNSALVGYQ------RQNDLKLEGMNETVSNLTQRVN--- 307
K L++++ + L++V S ++ + ++ + E + +T+S ++++
Sbjct: 1972 KEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSERE 2031
Query: 308 --LIES--DVVAMSKVEKKANLSFSMMGDRSATLKRQSLDQVTNRTDTVKIQ------SI 357
L+E +++A+ K FS++ ++ T ++++ QV + + +KIQ ++
Sbjct: 2032 QQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNL 2091
Query: 358 KKEDSSNSQVSKLREKLQLISALTNKPESNRPPETADEEQVE 399
++ NS + K ++L+ A N + R + ++ Q E
Sbjct: 2092 LEQKQENSCIQKEMATIELV-AQDNHERARRLMKELNQMQYE 2132
Score = 35.0 bits (79), Expect = 0.16
Identities = 66/334 (19%), Positives = 139/334 (41%), Gaps = 36/334 (10%)
Query: 98 LKEDLDALKEKFRTMESNQKSSFQEIPKLNEELLSKQKQLEKIE----SGEMGLNKVWIN 153
L E+L L++ E N+ Q + + L +K+ +LEK++ S + + +
Sbjct: 1543 LTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQ 1602
Query: 154 ITEMNKQISLLTSAVNHLKANVKSAADLISLPTT--------VEGLQKSVASIGNTLNSV 205
+ +++ LL ++ KA+++ A L T V+ L + ++ LN V
Sbjct: 1603 LGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELN-V 1661
Query: 206 HLAVEALQKTV--DEHKKTMELLQSDMNQHFLKETPGSNQIIPSPSATSELD------NK 257
++ Q T+ E +K E LQ + Q +T N + EL ++
Sbjct: 1662 QISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQ 1721
Query: 258 THSENLKQDILYLHNSLEEVNSALVGYQRQNDLK-----LEGMNETVSNLTQRVNLIESD 312
SE K + L LE N + Q++ +++ LE + +T ++S
Sbjct: 1722 RVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSC 1781
Query: 313 VVAMSK----VEKKANLSFSMMGDRSATLKRQSLDQVTNRTDTVKIQ-SIKKEDSSNSQV 367
V +SK +++K ++ + L + +++ K++ +++K Q+
Sbjct: 1782 VECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQL 1841
Query: 368 SKLREKLQL---ISALTNKPESNRPPETADEEQV 398
+ R+KL L ISA+ + + R + +E++
Sbjct: 1842 N--RDKLSLHNDISAMQQQLQEKREAVNSLQEEL 1873
Score = 29.6 bits (65), Expect = 6.6
Identities = 56/321 (17%), Positives = 131/321 (40%), Gaps = 50/321 (15%)
Query: 99 KEDLDALKEKFRTMESNQKSSFQEIPKLNEELLSKQKQLEKIESGEMGLNKVWIN----- 153
++ LD + ++++ +ES I K EE+ ++QL + G++ N+
Sbjct: 561 EQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTE---GQIAANEALKKDLEGV 617
Query: 154 ITEMNKQISLL----TSAVNHLKANVKSAADLISLPTTV--------------EGLQKSV 195
I+ + + + + T A N + L+ T V E ++K +
Sbjct: 618 ISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKEL 677
Query: 196 ASIGNTLNSVHLAVEALQKTVDEHKKTMELLQSDMNQHFLKETPGSNQI---IPSPSATS 252
A + + L H +LQ+T + + ++++ +NQ+ + + +
Sbjct: 678 AELESALQEQHEVNASLQQTQGD----LSAYEAELEARLNLRDAEANQLKEELEKVTRLT 733
Query: 253 ELDNKTHSENLKQDILYLHNSL-------------EEVNSALVGYQRQNDLKLEGMNETV 299
+L+ L+++ L N+L E+++ L Q N+L + + +
Sbjct: 734 QLEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQ 793
Query: 300 SNLTQRVN-LIESDVVA--MSKVEKKANLSFSMMGDRS-ATLKRQSLDQVTNRTDTVKIQ 355
++L V+ L+ + VA + ++ +K L M S + + +SL + + + +
Sbjct: 794 NHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILAR 853
Query: 356 SIKKEDSSNSQVSKLREKLQL 376
S + D + + KL+E++ L
Sbjct: 854 SKWERDEAQVRERKLQEEMAL 874
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 49.7 bits (117), Expect = 6e-06
Identities = 56/291 (19%), Positives = 131/291 (45%), Gaps = 31/291 (10%)
Query: 95 QVALKEDLDALKEKFRTMESNQKSSFQEI-PKLN----EELLSKQKQLEKIESGEMGLNK 149
+ A ++++AL+ K + +++S + I KL+ + L+ + L K++ E+ + +
Sbjct: 639 RAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKE 698
Query: 150 VWINITEMNKQISLLTSAVNHLKANVKSAADLISLPTTVEGLQKSVASIGNTLNSVHLAV 209
+ + + N+Q ++ + + LKA + DL + L+K+ + + + + +
Sbjct: 699 LEVLQAKCNEQTKVIDNFTSQLKATEEKLLDL-------DALRKASSEGKSEMKKLRQQL 751
Query: 210 EALQKTVDEHKKTMELLQSDMNQHFLKETPGSN-QIIPSPSATSELDNKTHSENLKQDIL 268
EA +K + +H + + +S +E G ++ SE+ E L++++
Sbjct: 752 EAAEKQI-KHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQV--KETLEKELQ 808
Query: 269 YLHNSLEEVNSALVGYQRQNDLKLEGMNETVSNLTQR---VNLIESDVVAMSKVEKKANL 325
L E + V QR M ETV+ L Q+ N++ SD+ + + NL
Sbjct: 809 ILKEKFAEASEEAVSVQR-------SMQETVNKLHQKEEQFNMLSSDLEKL-----RENL 856
Query: 326 SFSMMGDRSATLKRQSLDQVTNRTDTVKIQSIKKEDSSNSQVSKLREKLQL 376
+ R + + L + + + + +K ++SQ++K+ ++L+L
Sbjct: 857 ADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRL 907
Score = 41.6 bits (96), Expect = 0.002
Identities = 61/312 (19%), Positives = 123/312 (39%), Gaps = 40/312 (12%)
Query: 99 KEDLDALKEKFRTMESNQKSSF-------QEIPKLNEELLSKQKQLEKIESGEMGLNKVW 151
+ ++ +LKE F E + +++ K NE L SK + K S + L K
Sbjct: 521 QREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSK 580
Query: 152 INITEMNKQISLLTSAVNHLKANVKSAADLISLPTTVEGL----QKSVASIGNTLNSVHL 207
+ + Q ++ V+ K A+ L T +E + Q + ++ N +S
Sbjct: 581 LETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERA 640
Query: 208 AVEALQKTVDEHKKTMELLQSDMNQHFLKETPGSNQIIPSPSATSELDNKTHSENLKQDI 267
A H K ME L++ + +KE S + I S +E Q +
Sbjct: 641 A----------HAKEMEALRAKL-MKVIKEKENSLEAIRSKLDKAE----------DQHL 679
Query: 268 LYLHNSLEEVNSALVGYQRQNDL--KLEGMNETVSNLTQRVNLIESDVVAMSKVEKKANL 325
+ + ++L ++ A + + L K + + N T ++ E ++ + + K
Sbjct: 680 VEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKA--- 736
Query: 326 SFSMMGDRSATLKRQSLDQVTNRTDTVKIQSIKKEDSSNSQVSKLR-EKLQLISALTNKP 384
S G RQ L+ + ++I+ + ++S +L+ +L+L + N
Sbjct: 737 --SSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLS 794
Query: 385 ESNRPPETADEE 396
E ++ ET ++E
Sbjct: 795 EVSQVKETLEKE 806
Score = 41.6 bits (96), Expect = 0.002
Identities = 71/333 (21%), Positives = 135/333 (40%), Gaps = 31/333 (9%)
Query: 99 KEDLDALKEKFRTMESNQKSSFQEIPKLNEELLSKQKQLEKIESGEMGLNKVWINITEMN 158
+E L L++ E K + +E L +EL +KQ +K ++ + + + I
Sbjct: 995 EEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTK 1054
Query: 159 KQISLLTSAVNHLKANVKSAADLISLP----TTVEGLQKSVASI---GNTLNSVHLAVEA 211
++ L S + + N K +L +L VE L KS + + +E
Sbjct: 1055 EKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIET 1114
Query: 212 LQKTVDEHKKTMELLQSDMNQHFLKETPGSNQIIPSPSATSELDNKTHSENLKQDILYLH 271
L++ + + + LQ + N +E S D T + L+++ L+
Sbjct: 1115 LKQAAAQKSQQLSALQEE-NVKLAEELGRSR------------DEVTSHQKLEEERSVLN 1161
Query: 272 NSLEEVNSALVGYQRQNDLKLEGMNETVSNLTQRVNLIESDVVAMSKVEKKANLSFSMMG 331
N L E+ + + D + + +++S +T + L E D +++EK N + G
Sbjct: 1162 NQLLEMKKRESKFIKDADEEKASLQKSIS-ITSAL-LTEKD----AELEKLRNEVTVLRG 1215
Query: 332 DRSATLKRQSLDQVTNRTDTVKIQSIKKEDSSNSQVSKLREKLQLISALTNKPESNRPPE 391
+ ++ S+ Q T +D VK++ K N ++ K QL S+ N E
Sbjct: 1216 ENASAKSLHSVVQ-TLESDKVKLELKVK----NLELQLKENKRQLSSSSGNTDTQADEDE 1270
Query: 392 TADEEQVESFTSKPSALPKFSQFLGDPVEKAAQ 424
A E Q++ S L + +Q L VE ++
Sbjct: 1271 RAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSE 1303
Score = 35.0 bits (79), Expect = 0.16
Identities = 68/353 (19%), Positives = 149/353 (42%), Gaps = 38/353 (10%)
Query: 99 KEDLDALKEKFRT-----MESNQKSSFQEIPKLNEELLSKQKQLEKIESGEMGLNKVWIN 153
+E L KEK M+ + +S Q + K+N+EL K++ +E++ ++ L K N
Sbjct: 870 EEQLIKAKEKLENDIAEIMKMSGDNSSQ-LTKMNDELRLKERDVEEL---QLKLTKANEN 925
Query: 154 ITEMNKQISLLT--SAVNHLKANVKSAADLISLPTTVEGLQKSVASIGNTLNSVHLAVE- 210
+ + K I +T + + +A K + L + L+K + + N + E
Sbjct: 926 ASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYER 985
Query: 211 ALQKTVDEHKKTMELLQSDM--NQHFLKETPGSNQ-IIPSPSATSELDNKTHSENLKQDI 267
A +T +H++ ++ LQ + + LK N ++ + +K + +D
Sbjct: 986 ATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDA 1045
Query: 268 LYLHNSLEEVNSALVGYQRQNDLKLEGMNETVSNLTQRVN-LIESDVVAMSKVEKKANLS 326
+ + + + + + LE +T + L ++ L E+++ + ++ K L
Sbjct: 1046 MQIMEQMTKEKTETLA-------SLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKEL- 1097
Query: 327 FSMMGDRSATLKRQSLDQVTNRTDTVKIQSIKKEDSSNSQVSKLREK-LQLISALTNKPE 385
T++ Q +++ +T+K + +K + Q+S L+E+ ++L L +
Sbjct: 1098 --------LTVENQKMEEFRKEIETLKQAAAQK----SQQLSALQEENVKLAEELGRSRD 1145
Query: 386 SNRPPETADEEQVESFTSKPSALPKFSQFLGDPVEKAAQL-RPISLPGVSSTE 437
+ +EE+ + S+F+ D E+ A L + IS+ TE
Sbjct: 1146 EVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTE 1198
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 49.7 bits (117), Expect = 6e-06
Identities = 56/291 (19%), Positives = 131/291 (45%), Gaps = 31/291 (10%)
Query: 95 QVALKEDLDALKEKFRTMESNQKSSFQEI-PKLN----EELLSKQKQLEKIESGEMGLNK 149
+ A ++++AL+ K + +++S + I KL+ + L+ + L K++ E+ + +
Sbjct: 674 RAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKE 733
Query: 150 VWINITEMNKQISLLTSAVNHLKANVKSAADLISLPTTVEGLQKSVASIGNTLNSVHLAV 209
+ + + N+Q ++ + + LKA + DL + L+K+ + + + + +
Sbjct: 734 LEVLQAKCNEQTKVIDNFTSQLKATEEKLLDL-------DALRKASSEGKSEMKKLRQQL 786
Query: 210 EALQKTVDEHKKTMELLQSDMNQHFLKETPGSN-QIIPSPSATSELDNKTHSENLKQDIL 268
EA +K + +H + + +S +E G ++ SE+ E L++++
Sbjct: 787 EAAEKQI-KHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQV--KETLEKELQ 843
Query: 269 YLHNSLEEVNSALVGYQRQNDLKLEGMNETVSNLTQR---VNLIESDVVAMSKVEKKANL 325
L E + V QR M ETV+ L Q+ N++ SD+ + + NL
Sbjct: 844 ILKEKFAEASEEAVSVQR-------SMQETVNKLHQKEEQFNMLSSDLEKL-----RENL 891
Query: 326 SFSMMGDRSATLKRQSLDQVTNRTDTVKIQSIKKEDSSNSQVSKLREKLQL 376
+ R + + L + + + + +K ++SQ++K+ ++L+L
Sbjct: 892 ADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRL 942
Score = 41.6 bits (96), Expect = 0.002
Identities = 61/312 (19%), Positives = 123/312 (39%), Gaps = 40/312 (12%)
Query: 99 KEDLDALKEKFRTMESNQKSSF-------QEIPKLNEELLSKQKQLEKIESGEMGLNKVW 151
+ ++ +LKE F E + +++ K NE L SK + K S + L K
Sbjct: 556 QREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSK 615
Query: 152 INITEMNKQISLLTSAVNHLKANVKSAADLISLPTTVEGL----QKSVASIGNTLNSVHL 207
+ + Q ++ V+ K A+ L T +E + Q + ++ N +S
Sbjct: 616 LETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERA 675
Query: 208 AVEALQKTVDEHKKTMELLQSDMNQHFLKETPGSNQIIPSPSATSELDNKTHSENLKQDI 267
A H K ME L++ + +KE S + I S +E Q +
Sbjct: 676 A----------HAKEMEALRAKL-MKVIKEKENSLEAIRSKLDKAE----------DQHL 714
Query: 268 LYLHNSLEEVNSALVGYQRQNDL--KLEGMNETVSNLTQRVNLIESDVVAMSKVEKKANL 325
+ + ++L ++ A + + L K + + N T ++ E ++ + + K
Sbjct: 715 VEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKA--- 771
Query: 326 SFSMMGDRSATLKRQSLDQVTNRTDTVKIQSIKKEDSSNSQVSKLR-EKLQLISALTNKP 384
S G RQ L+ + ++I+ + ++S +L+ +L+L + N
Sbjct: 772 --SSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLS 829
Query: 385 ESNRPPETADEE 396
E ++ ET ++E
Sbjct: 830 EVSQVKETLEKE 841
Score = 41.6 bits (96), Expect = 0.002
Identities = 71/333 (21%), Positives = 135/333 (40%), Gaps = 31/333 (9%)
Query: 99 KEDLDALKEKFRTMESNQKSSFQEIPKLNEELLSKQKQLEKIESGEMGLNKVWINITEMN 158
+E L L++ E K + +E L +EL +KQ +K ++ + + + I
Sbjct: 1030 EEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTK 1089
Query: 159 KQISLLTSAVNHLKANVKSAADLISLP----TTVEGLQKSVASI---GNTLNSVHLAVEA 211
++ L S + + N K +L +L VE L KS + + +E
Sbjct: 1090 EKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIET 1149
Query: 212 LQKTVDEHKKTMELLQSDMNQHFLKETPGSNQIIPSPSATSELDNKTHSENLKQDILYLH 271
L++ + + + LQ + N +E S D T + L+++ L+
Sbjct: 1150 LKQAAAQKSQQLSALQEE-NVKLAEELGRSR------------DEVTSHQKLEEERSVLN 1196
Query: 272 NSLEEVNSALVGYQRQNDLKLEGMNETVSNLTQRVNLIESDVVAMSKVEKKANLSFSMMG 331
N L E+ + + D + + +++S +T + L E D +++EK N + G
Sbjct: 1197 NQLLEMKKRESKFIKDADEEKASLQKSIS-ITSAL-LTEKD----AELEKLRNEVTVLRG 1250
Query: 332 DRSATLKRQSLDQVTNRTDTVKIQSIKKEDSSNSQVSKLREKLQLISALTNKPESNRPPE 391
+ ++ S+ Q T +D VK++ K N ++ K QL S+ N E
Sbjct: 1251 ENASAKSLHSVVQ-TLESDKVKLELKVK----NLELQLKENKRQLSSSSGNTDTQADEDE 1305
Query: 392 TADEEQVESFTSKPSALPKFSQFLGDPVEKAAQ 424
A E Q++ S L + +Q L VE ++
Sbjct: 1306 RAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSE 1338
Score = 35.0 bits (79), Expect = 0.16
Identities = 68/353 (19%), Positives = 149/353 (42%), Gaps = 38/353 (10%)
Query: 99 KEDLDALKEKFRT-----MESNQKSSFQEIPKLNEELLSKQKQLEKIESGEMGLNKVWIN 153
+E L KEK M+ + +S Q + K+N+EL K++ +E++ ++ L K N
Sbjct: 905 EEQLIKAKEKLENDIAEIMKMSGDNSSQ-LTKMNDELRLKERDVEEL---QLKLTKANEN 960
Query: 154 ITEMNKQISLLT--SAVNHLKANVKSAADLISLPTTVEGLQKSVASIGNTLNSVHLAVE- 210
+ + K I +T + + +A K + L + L+K + + N + E
Sbjct: 961 ASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYER 1020
Query: 211 ALQKTVDEHKKTMELLQSDM--NQHFLKETPGSNQ-IIPSPSATSELDNKTHSENLKQDI 267
A +T +H++ ++ LQ + + LK N ++ + +K + +D
Sbjct: 1021 ATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDA 1080
Query: 268 LYLHNSLEEVNSALVGYQRQNDLKLEGMNETVSNLTQRVN-LIESDVVAMSKVEKKANLS 326
+ + + + + + LE +T + L ++ L E+++ + ++ K L
Sbjct: 1081 MQIMEQMTKEKTETLA-------SLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKEL- 1132
Query: 327 FSMMGDRSATLKRQSLDQVTNRTDTVKIQSIKKEDSSNSQVSKLREK-LQLISALTNKPE 385
T++ Q +++ +T+K + +K + Q+S L+E+ ++L L +
Sbjct: 1133 --------LTVENQKMEEFRKEIETLKQAAAQK----SQQLSALQEENVKLAEELGRSRD 1180
Query: 386 SNRPPETADEEQVESFTSKPSALPKFSQFLGDPVEKAAQL-RPISLPGVSSTE 437
+ +EE+ + S+F+ D E+ A L + IS+ TE
Sbjct: 1181 EVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTE 1233
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 49.3 bits (116), Expect = 8e-06
Identities = 65/302 (21%), Positives = 124/302 (41%), Gaps = 57/302 (18%)
Query: 95 QVALKEDLDAL-KEKFRTMESNQKSSFQEIPKLNEELLSKQKQLEKIESGEMGLNKVWIN 153
Q L + DAL E +M S +++S + KLN++LLSK +QL + S L +
Sbjct: 2774 QGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSS---QLEDSYNQ 2830
Query: 154 ITEMNKQISLLTSAVNHL-----------KANVKSAADLISLPTTVEGLQKSVASIGN-- 200
+ +K ++ L + +HL + +SAA + P V+ L+K+++S+ N
Sbjct: 2831 VQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDR 2890
Query: 201 -------------------TLNSVHLAVEALQKTVDEHKKTMELLQSDMNQHFLKETPGS 241
+ +H LQ+ D+ K +++Q ++ Q L
Sbjct: 2891 DRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDK-TKAFQIMQEELRQENLSWQHEL 2949
Query: 242 NQIIPSPSATSELDNKTHSENL------KQDILYLHNSLEEVNSA-------LVGYQRQN 288
+Q+ S+ + + + L Q + +L N + E+ S+ V YQRQ
Sbjct: 2950 HQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQA 3009
Query: 289 DLKLEGMNETVSNLTQRVNLIESDV-VAMSKVEKK------ANLSFSMMGDRSATLKRQS 341
+ + NL L+ + + ++ ++ +K N +FS + + TL Q
Sbjct: 3010 SPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQL 3069
Query: 342 LD 343
D
Sbjct: 3070 CD 3071
Score = 47.8 bits (112), Expect = 2e-05
Identities = 61/315 (19%), Positives = 126/315 (40%), Gaps = 38/315 (12%)
Query: 101 DLDALKEKFRTMESNQKSSFQEIPKLNEELLSKQKQLEKIESGEMGLNKVWINITEMNKQ 160
+L+ L E+F+ N S+F + + ++LLS+ K+L + + ++ +N+ E +Q
Sbjct: 720 NLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQ 779
Query: 161 ISLLTSAVNHLKANVKSAADLISLPTTVEGLQKSVASIGNTLNSVHLAVEALQKTVD--- 217
L ++A D + L + + S+ S + +E LQ +D
Sbjct: 780 --------RRLDYESQTAHDNL--------LTEQIHSLSIEAKSKDVKIEVLQNELDDVQ 823
Query: 218 ----EHKKTMELLQSDMNQHFLKETPGSNQIIPSPSATSELDNKTHSENL---------- 263
E + LQS + + G+ ++ S EL + L
Sbjct: 824 LQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLL 883
Query: 264 --KQDILYLHNSLEEVNSALVGYQRQNDLKLEGMNETVSNLTQRVNLIESDVVAMSKVEK 321
K+D+ L ++EE + + K+ +NE +L + ++ + +S+ E+
Sbjct: 884 EKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEE 943
Query: 322 KANLSFSMMGDRSATLKRQSLDQVTNRTDTVKIQSIKKEDSSNSQVSKLREKLQLISALT 381
+ S+ LK Q+ D+++ K + + D + + + KLQ +AL
Sbjct: 944 AKKEQVEEDNEVSSGLK-QNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQ--AALI 1000
Query: 382 NKPESNRPPETADEE 396
N+ E + +EE
Sbjct: 1001 NRKELLQRVSRLEEE 1015
Score = 37.7 bits (86), Expect = 0.024
Identities = 59/283 (20%), Positives = 123/283 (43%), Gaps = 32/283 (11%)
Query: 89 VGLVWMQVALKEDLDALKEKFRTMESNQKSSFQEIPKLNEELLSKQKQLEKIESGEMGLN 148
+GL Q+ +KE E+ + + SS + I +L EEL+ QK+ K + GE+ +
Sbjct: 2627 LGLYHAQLKVKE------EEVHRLSALFSSSQKRIAELEEELVCVQKEAAK-KVGEIE-D 2678
Query: 149 KVWINITEMNKQISLLTSAVNHLKANV-KSAADLISLPTTV-------EGLQKSVASIGN 200
K+ + ++ ++ + + V + A DL+ + + +GL + S G
Sbjct: 2679 KLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGR 2738
Query: 201 TLNSVHLAVEALQKTVDEHKKTMELLQSDMNQHFLKETPGSNQIIPSPSATSELDNKTHS 260
+++S+ + + + +DE K+ + ++ Q LKE Q + + + L S
Sbjct: 2739 SMSSLQNSRDHANEELDELKRKYDASLKELAQ--LKE-----QGLLNRERDALLSETAFS 2791
Query: 261 ENLKQDILYLHNSLEEVNSALVGYQRQNDLKLEGMNETVSNLTQRVNLIESDVVAMSKVE 320
N ++ H LE++N L+ K E + S L N ++S AM+ ++
Sbjct: 2792 MNSTEENSLSH--LEKLNQQLLS-------KDEQLLHLSSQLEDSYNQVQSFSKAMASLQ 2842
Query: 321 KKANLSFSMMGDRSATLKRQSLDQVTNRTDTVKIQSIKKEDSS 363
+ + ++ + + + + T ++QS+KK SS
Sbjct: 2843 NERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSS 2885
Score = 37.0 bits (84), Expect = 0.041
Identities = 70/388 (18%), Positives = 149/388 (38%), Gaps = 43/388 (11%)
Query: 98 LKEDLDALKEKFRTMESNQKSSFQEIPKLNEELLS------KQKQLEKIESGEMGLNKVW 151
LK++ + K K + N+K Q + +L EEL + K+ L + E GE+ +K
Sbjct: 984 LKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDK-- 1041
Query: 152 INITEMNKQIS--LLTSAVNHLKANVKSAADLISLPTTVEGLQKSVASIGNTLNSVHLAV 209
NK+ S +TS ++ +K + ++ ++K + V
Sbjct: 1042 -----ENKEYSEKCVTSKCQEIEIYLKQT--ISEKEVELQHIRKDLEEKLAAEEQFQALV 1094
Query: 210 EALQKTVDEHKKTMELLQSDM--NQHFLKETPGSN--------------QIIPSPSATSE 253
+ + +T+ + ++LLQ+++ NQ +++ SN ++ SP T
Sbjct: 1095 KQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGS 1154
Query: 254 LDNKTHSENLKQDILYLHNSLEEVNSALVGYQRQNDLKLEGMNETVSNLTQRVNLIESDV 313
++ L++ IL L E++ L L+ E +L + + + D
Sbjct: 1155 SEH--WKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDY 1212
Query: 314 VAMSKVEKKANLSFSMMGDRSATLK---RQSLDQVTNRTDTVKIQSIKKEDSSNSQVSKL 370
+ + + + +GD+ L+ R+S+D TD + +S + K
Sbjct: 1213 NRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTD--QQESCSSTPGLEEPLFKA 1270
Query: 371 REKLQLISALTNKPESNRPPETADEEQVESFTSKPSALPKFSQFLGDPVEKAAQLRPISL 430
E+ L + + P + D ++ TS + + + VE ++ +
Sbjct: 1271 TEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTS 1330
Query: 431 PGVSSTED---LQDLFRKTGQDVDGKLT 455
+E+ LQ+ K G +++ T
Sbjct: 1331 ELTKKSEEVFQLQEQINKQGLEIESLKT 1358
Score = 35.8 bits (81), Expect = 0.092
Identities = 68/321 (21%), Positives = 122/321 (38%), Gaps = 58/321 (18%)
Query: 91 LVWMQVALKEDLDALKEKFRTMESNQKSSFQEIPKLNEELLSKQKQLEKIESGEMGLNKV 150
L+ ++KE+L+ +K ++ T+ +S E L+EE+ + Q+E S + L
Sbjct: 1717 LLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEAT 1776
Query: 151 -----WINIT---------EMNKQISLLTSAVNHLKANVKSAADLISLPTTVEGLQKSVA 196
N+T E +Q SL S +V SA S V S
Sbjct: 1777 EKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAK---SANPAVSKDFSSHD 1833
Query: 197 SIGNTLNSVHLAVEALQKTVDEHKKTMELLQSDMNQ-----HFLKETPGSNQIIPSPSAT 251
I N L + E + +E +K E Q+ N+ + G +++
Sbjct: 1834 EINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTK 1893
Query: 252 SELDNKTHSENL-------------KQDI-LYLHNSLEEVNSALVGYQR---QNDLKLEG 294
L N+ E L K D+ L N L E+N ++ Y + +K E
Sbjct: 1894 MNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNEL 1953
Query: 295 MNETVSNLTQRVNLIESDVVAMSKVEKKANLSFSMMGDRSATLKRQSLDQVTNRTDTVKI 354
+ + NL + V+ +E + + K + K + ++++ L+ KI
Sbjct: 1954 LESEMKNLKKCVSELEEEKQQLVKEKTKV----------ESEIRKEYLE---------KI 1994
Query: 355 QSIKKEDSSNSQVSKLREKLQ 375
Q +KE + S +L+E L+
Sbjct: 1995 QGAQKEPGNKSHAKELQELLK 2015
Score = 35.0 bits (79), Expect = 0.16
Identities = 63/336 (18%), Positives = 127/336 (37%), Gaps = 45/336 (13%)
Query: 91 LVWMQVALKEDLDALKEKFRTMESNQKSSFQEIPKLNEELLSKQKQLEKIESGEMGLNK- 149
L ++Q ++DL+ KE ++K + E+ L Q + ++ + + L K
Sbjct: 2045 LEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKE 2104
Query: 150 VWINITEMNKQIS---------LLTSAVNHLKANVKSAADLISLPTTVEGLQKSVASIGN 200
+ N + Q+ L + HLK L +L L++++ I
Sbjct: 2105 LQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQV 2164
Query: 201 TLNSVHLAVEALQKTVDE-------HKKTMELLQSDMNQHFLKETPGSNQIIPSPSATSE 253
TLN V+ LQ+ +D K+M LQ D ++ + + +
Sbjct: 2165 TLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKF------SDA 2218
Query: 254 LDNKTHSENLKQDILYLHNSLEEVNSALVGYQRQNDLKLEGMNETVSNLTQRVNLIESDV 313
+ +K LK+D S L RQ + +E + +S L + ES
Sbjct: 2219 IQSKEEEIRLKEDNC----------SVLKDQLRQMSIHMEELKINISRLEHDKQIWESK- 2267
Query: 314 VAMSKVEKKANLSFSMMGDRSATLKR---------QSLDQVTNRTDTVKIQSIKKEDSSN 364
A ++V+ + + ++ G+ L + S +++ +K + D SN
Sbjct: 2268 -AQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSN 2326
Query: 365 SQVSKLREKLQLISALTNKPESNRPPETADEEQVES 400
S + K +E+ + + + E++ EQ+E+
Sbjct: 2327 S-LEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLET 2361
Score = 30.8 bits (68), Expect = 3.0
Identities = 58/292 (19%), Positives = 127/292 (43%), Gaps = 15/292 (5%)
Query: 90 GLVWMQVALKEDLDALKEKFRTMESNQKSSFQEIPKLNEELLSKQKQLEKIESGEMGLNK 149
G++ Q A D+ K + +E++ ++S + +L+EE+ K++++ + SG+
Sbjct: 2340 GIIRQQEA---DIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKE--EA 2394
Query: 150 VWINITEMNKQISLLTSAVNHLKANVKSAADLISLPTTVEGLQKSVASIGNTLNSVHLAV 209
+ + I E+ +Q + +L + + + I L + + TL ++
Sbjct: 2395 IQVAIAELRQQHDKEIKELENLLS--QEEEENIVLEEENKKAVDKTNQLMETLKTIKKEN 2452
Query: 210 EALQKTVDEHKKTMELLQSDMNQHFLKETPGSNQIIPSPSATSELDNKTHSEN--LKQDI 267
+ +D K+M LQ+D ++ + + +L + +EN LK++I
Sbjct: 2453 IQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEI 2512
Query: 268 LYLHNSLEEVNSALVGYQRQNDLKLEGMNETVS-NLTQRVNLIESDVVAMSKVEKK-ANL 325
L + ++++NS + E +N+ ++ +Q+ L+E + ++E K A L
Sbjct: 2513 RGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKL 2572
Query: 326 SFSMMGDRSAT--LKRQSLDQVTNRTDTVK-IQSIKKEDSS-NSQVSKLREK 373
+ A L+R + D K I+S+K S QV+ L+E+
Sbjct: 2573 EEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEE 2624
>gi|33946313 ninein isoform 4 [Homo sapiens]
Length = 2096
Score = 48.9 bits (115), Expect = 1e-05
Identities = 75/335 (22%), Positives = 133/335 (39%), Gaps = 41/335 (12%)
Query: 103 DALKEKFRTMES-------NQKSSFQEIPKLNEELLSKQKQLEKIESGEMGLNKVWINIT 155
D L+E+ R ME+ N K E+ +L +EL ++ E S E ++V I
Sbjct: 1266 DCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENE 1325
Query: 156 EMNKQISLLTSAVNHLKANVKSAADLISLPTTVEGLQKSVASIGNTLNSVHLAVEALQKT 215
E+N + L + L+ +V D ++E L+ + GN L E + +
Sbjct: 1326 ELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLE--IEPDGNILQLNQTLEECVPRV 1383
Query: 216 VDEHKKTMELLQSDMNQHFLKETPGSNQIIPSPSATSELDNKTHSENLKQDILYLHNSLE 275
H E Q NQ+ T ++ A +TH E + + +
Sbjct: 1384 RSVHHVIEECKQE--NQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQ----NQVIL 1437
Query: 276 EVNSALVGYQRQN--------DLKLE--GMNETVSNLTQRVNLIESDVVAMSKVEKKANL 325
E N+ L+G+Q ++ +L+LE + E L +RV ++ +S EK+ L
Sbjct: 1438 EENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEEL 1497
Query: 326 SFSMMGDRSATLKRQSLDQVTNRTDTVKIQ-----------SIKKEDS-SNSQVSKLREK 373
+MM D T R ++ K+Q ++ +EDS SN ++ L
Sbjct: 1498 K-AMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGS 1556
Query: 374 LQLISALTNKPESNRPPETADEEQVESFTSKPSAL 408
+ + K E+ + A ++ VE+ + S L
Sbjct: 1557 QE---EMWQKTETVKQENAAVQKMVENLKKQISEL 1588
Score = 34.3 bits (77), Expect = 0.27
Identities = 70/354 (19%), Positives = 143/354 (40%), Gaps = 46/354 (12%)
Query: 105 LKEKFRTMESNQKSSFQEIPKLNEELLSKQKQLEKIESGEMGLNKVWINITEMNKQISLL 164
L+ + TM+ QKS + L +L++ Q++++ +E +N + ++ M + +
Sbjct: 1742 LEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVN---LQMSRMKSDLRVT 1798
Query: 165 TSAVNHLKANVKS-------------AADLISLPTTVEGLQKSVASIGNTLNSVHLAVEA 211
LK V S A ++ + P+ + QK ++ + L+ HL E
Sbjct: 1799 QQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLS--WDKLD--HLMNEE 1854
Query: 212 LQKTVDEHKKTMELLQ---SDMNQHFLKETPGSNQIIP------SPSATSELDNKTHSE- 261
Q E+++ ++Q +++ K + ++P +PS T N T E
Sbjct: 1855 QQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTM---NPTEQEK 1911
Query: 262 -NLKQDILYLHNSLEEVNSALVGYQRQNDLKLEGMNETVSNLTQRVNLIESDVVAMSKVE 320
+LK++ N V + +LE ++ L ++ ++ ++ M +
Sbjct: 1912 LSLKRECDQFQKEQSPANRK-VSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLR 1970
Query: 321 KKANLSFSMMGDRSATLKRQSLDQVTNRTDTVKIQSIKKEDSSNSQVSKLREKLQLISAL 380
A S S L++Q+ V + + + + N L+E+L+ ++
Sbjct: 1971 STATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQH---LQEELENRTSE 2027
Query: 381 TNKPESNRPP-ETADEEQVESFTSKPSALPKFSQFLGDPVEKAAQLR-PISLPG 432
TN P+ N+ T EE++ K + + Q EK QL+ +SLPG
Sbjct: 2028 TNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQ------EKVNQLKEQVSLPG 2075
>gi|33946321 ninein isoform 5 [Homo sapiens]
Length = 2090
Score = 48.9 bits (115), Expect = 1e-05
Identities = 75/335 (22%), Positives = 133/335 (39%), Gaps = 41/335 (12%)
Query: 103 DALKEKFRTMES-------NQKSSFQEIPKLNEELLSKQKQLEKIESGEMGLNKVWINIT 155
D L+E+ R ME+ N K E+ +L +EL ++ E S E ++V I
Sbjct: 1260 DCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENE 1319
Query: 156 EMNKQISLLTSAVNHLKANVKSAADLISLPTTVEGLQKSVASIGNTLNSVHLAVEALQKT 215
E+N + L + L+ +V D ++E L+ + GN L E + +
Sbjct: 1320 ELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLE--IEPDGNILQLNQTLEECVPRV 1377
Query: 216 VDEHKKTMELLQSDMNQHFLKETPGSNQIIPSPSATSELDNKTHSENLKQDILYLHNSLE 275
H E Q NQ+ T ++ A +TH E + + +
Sbjct: 1378 RSVHHVIEECKQE--NQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQ----NQVIL 1431
Query: 276 EVNSALVGYQRQN--------DLKLE--GMNETVSNLTQRVNLIESDVVAMSKVEKKANL 325
E N+ L+G+Q ++ +L+LE + E L +RV ++ +S EK+ L
Sbjct: 1432 EENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEEL 1491
Query: 326 SFSMMGDRSATLKRQSLDQVTNRTDTVKIQ-----------SIKKEDS-SNSQVSKLREK 373
+MM D T R ++ K+Q ++ +EDS SN ++ L
Sbjct: 1492 K-AMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGS 1550
Query: 374 LQLISALTNKPESNRPPETADEEQVESFTSKPSAL 408
+ + K E+ + A ++ VE+ + S L
Sbjct: 1551 QE---EMWQKTETVKQENAAVQKMVENLKKQISEL 1582
Score = 34.3 bits (77), Expect = 0.27
Identities = 70/354 (19%), Positives = 143/354 (40%), Gaps = 46/354 (12%)
Query: 105 LKEKFRTMESNQKSSFQEIPKLNEELLSKQKQLEKIESGEMGLNKVWINITEMNKQISLL 164
L+ + TM+ QKS + L +L++ Q++++ +E +N + ++ M + +
Sbjct: 1736 LEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVN---LQMSRMKSDLRVT 1792
Query: 165 TSAVNHLKANVKS-------------AADLISLPTTVEGLQKSVASIGNTLNSVHLAVEA 211
LK V S A ++ + P+ + QK ++ + L+ HL E
Sbjct: 1793 QQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLS--WDKLD--HLMNEE 1848
Query: 212 LQKTVDEHKKTMELLQ---SDMNQHFLKETPGSNQIIP------SPSATSELDNKTHSE- 261
Q E+++ ++Q +++ K + ++P +PS T N T E
Sbjct: 1849 QQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTM---NPTEQEK 1905
Query: 262 -NLKQDILYLHNSLEEVNSALVGYQRQNDLKLEGMNETVSNLTQRVNLIESDVVAMSKVE 320
+LK++ N V + +LE ++ L ++ ++ ++ M +
Sbjct: 1906 LSLKRECDQFQKEQSPANRK-VSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLR 1964
Query: 321 KKANLSFSMMGDRSATLKRQSLDQVTNRTDTVKIQSIKKEDSSNSQVSKLREKLQLISAL 380
A S S L++Q+ V + + + + N L+E+L+ ++
Sbjct: 1965 STATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQH---LQEELENRTSE 2021
Query: 381 TNKPESNRPP-ETADEEQVESFTSKPSALPKFSQFLGDPVEKAAQLR-PISLPG 432
TN P+ N+ T EE++ K + + Q EK QL+ +SLPG
Sbjct: 2022 TNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQ------EKVNQLKEQVSLPG 2069
>gi|148536871 ninein isoform 1 [Homo sapiens]
Length = 2046
Score = 48.9 bits (115), Expect = 1e-05
Identities = 75/335 (22%), Positives = 133/335 (39%), Gaps = 41/335 (12%)
Query: 103 DALKEKFRTMES-------NQKSSFQEIPKLNEELLSKQKQLEKIESGEMGLNKVWINIT 155
D L+E+ R ME+ N K E+ +L +EL ++ E S E ++V I
Sbjct: 1260 DCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENE 1319
Query: 156 EMNKQISLLTSAVNHLKANVKSAADLISLPTTVEGLQKSVASIGNTLNSVHLAVEALQKT 215
E+N + L + L+ +V D ++E L+ + GN L E + +
Sbjct: 1320 ELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLE--IEPDGNILQLNQTLEECVPRV 1377
Query: 216 VDEHKKTMELLQSDMNQHFLKETPGSNQIIPSPSATSELDNKTHSENLKQDILYLHNSLE 275
H E Q NQ+ T ++ A +TH E + + +
Sbjct: 1378 RSVHHVIEECKQE--NQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQ----NQVIL 1431
Query: 276 EVNSALVGYQRQN--------DLKLE--GMNETVSNLTQRVNLIESDVVAMSKVEKKANL 325
E N+ L+G+Q ++ +L+LE + E L +RV ++ +S EK+ L
Sbjct: 1432 EENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEEL 1491
Query: 326 SFSMMGDRSATLKRQSLDQVTNRTDTVKIQ-----------SIKKEDS-SNSQVSKLREK 373
+MM D T R ++ K+Q ++ +EDS SN ++ L
Sbjct: 1492 K-AMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGS 1550
Query: 374 LQLISALTNKPESNRPPETADEEQVESFTSKPSAL 408
+ + K E+ + A ++ VE+ + S L
Sbjct: 1551 QE---EMWQKTETVKQENAAVQKMVENLKKQISEL 1582
Score = 29.6 bits (65), Expect = 6.6
Identities = 58/313 (18%), Positives = 126/313 (40%), Gaps = 38/313 (12%)
Query: 105 LKEKFRTMESNQKSSFQEIPKLNEELLSKQKQLEKIESGEMGLNKVWINITEMNKQISLL 164
L+ + TM+ QKS + L +L++ Q++++ +E +N + ++ M + +
Sbjct: 1736 LEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVN---LQMSRMKSDLRVT 1792
Query: 165 TSAVNHLKANVKS-------------AADLISLPTTVEGLQKSVASIGNTLNSVHLAVEA 211
LK V S A ++ + P+ + QK ++ + L+ HL E
Sbjct: 1793 QQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLS--WDKLD--HLMNEE 1848
Query: 212 LQKTVDEHKKTMELLQ---SDMNQHFLKETPGSNQIIP------SPSATSELDNKTHSE- 261
Q E+++ ++Q +++ K + ++P +PS T N T E
Sbjct: 1849 QQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTM---NPTEQEK 1905
Query: 262 -NLKQDILYLHNSLEEVNSALVGYQRQNDLKLEGMNETVSNLTQRVNLIESDVVAMSKVE 320
+LK++ N V + +LE ++ L ++ ++ ++ M +
Sbjct: 1906 LSLKRECDQFQKEQSPANRK-VSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLR 1964
Query: 321 KKANLSFSMMGDRSATLKRQSLDQVTNRTDTVKIQSIKKEDSSNSQVSKLREKLQLISAL 380
A S S L++Q+ V + + + + N L+E+L+ ++
Sbjct: 1965 STATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQH---LQEELENRTSE 2021
Query: 381 TNKPESNRPPETA 393
TN P++ P + A
Sbjct: 2022 TNTPQALLPEQRA 2034
>gi|148536869 ninein isoform 2 [Homo sapiens]
Length = 2133
Score = 48.9 bits (115), Expect = 1e-05
Identities = 75/335 (22%), Positives = 133/335 (39%), Gaps = 41/335 (12%)
Query: 103 DALKEKFRTMES-------NQKSSFQEIPKLNEELLSKQKQLEKIESGEMGLNKVWINIT 155
D L+E+ R ME+ N K E+ +L +EL ++ E S E ++V I
Sbjct: 1260 DCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENE 1319
Query: 156 EMNKQISLLTSAVNHLKANVKSAADLISLPTTVEGLQKSVASIGNTLNSVHLAVEALQKT 215
E+N + L + L+ +V D ++E L+ + GN L E + +
Sbjct: 1320 ELNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLE--IEPDGNILQLNQTLEECVPRV 1377
Query: 216 VDEHKKTMELLQSDMNQHFLKETPGSNQIIPSPSATSELDNKTHSENLKQDILYLHNSLE 275
H E Q NQ+ T ++ A +TH E + + +
Sbjct: 1378 RSVHHVIEECKQE--NQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQ----NQVIL 1431
Query: 276 EVNSALVGYQRQN--------DLKLE--GMNETVSNLTQRVNLIESDVVAMSKVEKKANL 325
E N+ L+G+Q ++ +L+LE + E L +RV ++ +S EK+ L
Sbjct: 1432 EENTTLLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEEL 1491
Query: 326 SFSMMGDRSATLKRQSLDQVTNRTDTVKIQ-----------SIKKEDS-SNSQVSKLREK 373
+MM D T R ++ K+Q ++ +EDS SN ++ L
Sbjct: 1492 K-AMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGS 1550
Query: 374 LQLISALTNKPESNRPPETADEEQVESFTSKPSAL 408
+ + K E+ + A ++ VE+ + S L
Sbjct: 1551 QE---EMWQKTETVKQENAAVQKMVENLKKQISEL 1582
Score = 32.3 bits (72), Expect = 1.0
Identities = 69/369 (18%), Positives = 146/369 (39%), Gaps = 45/369 (12%)
Query: 105 LKEKFRTMESNQKSSFQEIPKLNEELLSKQKQLEKIESGEMGLNKVWINITEMNKQISLL 164
L+ + TM+ QKS + L +L++ Q++++ +E +N + ++ M + +
Sbjct: 1736 LEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVN---LQMSRMKSDLRVT 1792
Query: 165 TSAVNHLKANVKS-------------AADLISLPTTVEGLQKSVASIGNTLNSVHLAVEA 211
LK V S A ++ + P+ + QK ++ + L+ HL E
Sbjct: 1793 QQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLS--WDKLD--HLMNEE 1848
Query: 212 LQKTVDEHKKTMELLQ---SDMNQHFLKETPGSNQIIP------SPSATSELDNKTHSE- 261
Q E+++ ++Q +++ K + ++P +PS T N T E
Sbjct: 1849 QQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTM---NPTEQEK 1905
Query: 262 -NLKQDILYLHNSLEEVNSALVGYQRQNDLKLEGMNETVSNLTQRVNLIESDVVAMSKVE 320
+LK++ N V + +LE ++ L ++ ++ ++ M +
Sbjct: 1906 LSLKRECDQFQKEQSPANRK-VSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEMQHLR 1964
Query: 321 KKANLSFSMMGDRSATLKRQSLDQVTNRTDTVKIQSIKKEDSSNSQVSKLREKLQLISAL 380
A S S L++Q+ V + + + + N L+E+L+ ++
Sbjct: 1965 STATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQH---LQEELENRTSE 2021
Query: 381 TNKPESNRPP-ETADEEQVESFTSKPSALPKFSQFLGDPVEKAAQLRPISLPGVSSTEDL 439
TN P+ N+ T EE++ K + + Q EK QL+ + +
Sbjct: 2022 TNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQ------EKVNQLKEQLCKNTKADAMV 2075
Query: 440 QDLFRKTGQ 448
+DL+ + Q
Sbjct: 2076 KDLYVENAQ 2084
>gi|63252900 tropomyosin 1 alpha chain isoform 4 [Homo sapiens]
Length = 284
Score = 48.1 bits (113), Expect = 2e-05
Identities = 60/284 (21%), Positives = 124/284 (43%), Gaps = 35/284 (12%)
Query: 98 LKEDLDALKEKFRTMESNQKSSFQEIPKLNEELLSKQKQLEKIESGEMGLNKVWINITEM 157
LK D + ++ E+++K++ +L +EL+S QK+L+ E E+
Sbjct: 11 LKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTED-------------EL 57
Query: 158 NKQISLLTSAVNHLKANVKSA----ADLISLPTTVEGLQKSVASIGNTLNSVHLAVEALQ 213
+K L A L+ K A AD+ SL ++ +++ + L + +E +
Sbjct: 58 DKYSEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAE 117
Query: 214 KTVDEHKKTMELLQSDMNQHFLKETPGSNQIIPSPSATSELDNKTHSENLKQDILYLHNS 273
K DE ++ M++++S + K Q+ + + D K E + + ++ + +
Sbjct: 118 KAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRK--YEEVARKLVIIESD 175
Query: 274 LEEVNSAL---VGYQRQNDLKLEGMNETVSNL-------TQRVNLIESDVVAMSKVEKKA 323
LE G RQ + +L M++T+ L +Q+ + E ++ +S K+A
Sbjct: 176 LERAEERAELSEGQVRQLEEQLRIMDQTLKALMAAEDKYSQKEDRYEEEIKVLSDKLKEA 235
Query: 324 NLSFSMMGDRSATLKRQSLDQVTNRTDTVKIQSIKKEDSSNSQV 367
+ + +RS T +S+D + K+ K+E+ S Q+
Sbjct: 236 E-TRAEFAERSVTKLEKSIDDLEE-----KVAHAKEENLSMHQM 273
>gi|112420968 coiled-coil domain containing 158 [Homo sapiens]
Length = 1113
Score = 47.8 bits (112), Expect = 2e-05
Identities = 72/352 (20%), Positives = 141/352 (40%), Gaps = 52/352 (14%)
Query: 94 MQVALKEDLDALKEKFRTMESNQKSSFQEIPKLNEELLSKQKQLEKIESGEMGLNKVWIN 153
+++ L++ D +++ E ++ + S Q Q+E I+ N +++
Sbjct: 258 IELLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQMEIIQEQARNQNSMYM- 316
Query: 154 ITEMNKQISLLTSAVNHLKANVKSAADLISLPTTVEGLQKSVASIGNTLNSVHLAVEA-- 211
+Q+S L S V+ L++ ++ A + T E L+K + + L +
Sbjct: 317 -----RQLSDLESTVSQLRSELREAKRMYEDKT--EELEKQLVLANSELTEARTERDQFS 369
Query: 212 ---------LQKTV-DEHKKTMEL-LQSDMNQHFLKETPGSNQIIPSPSATSELDNKTHS 260
LQK + D HK+ EL L+ + N+ G++ I ELDN+
Sbjct: 370 QESGNLDDQLQKLLADLHKREKELSLEKEQNKRLWDRDTGNS--ITIDHLRRELDNRN-- 425
Query: 261 ENLKQDILYLHNSLEEVNSALVGYQRQNDLKLEGMNETVSNLTQRVNLIESDVVAMSKVE 320
++ L L+ + S G + ++G NE++ ++ +ES + KV
Sbjct: 426 ----MEVQRLEALLKALKSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVV 481
Query: 321 KKANLSFSMMGDRSATLKRQSLDQVTNRTDTVKIQSIKKE---DSSNSQVSKLRE----K 373
++ T K+ +L+ + +KE +++N++++KLR K
Sbjct: 482 EE------------LTAKKMTLESSERTISDLTTSLQEKERAIEATNAEITKLRSRVDLK 529
Query: 374 LQLISALTNKPESNRPPETADEEQVESFTSKPSALPKFSQFLGDPVEKAAQL 425
LQ + L N+ + R +T E T K K + L +E QL
Sbjct: 530 LQELQHLKNEGDHLRNVQTECEALKLQMTEK----DKVIEILRQQIENMTQL 577
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 47.8 bits (112), Expect = 2e-05
Identities = 66/311 (21%), Positives = 128/311 (41%), Gaps = 36/311 (11%)
Query: 98 LKEDLDALKEKF----RTMESNQKSSFQEIPKLNEELLSKQKQLEKIESGEMGLNKVWIN 153
LK +L++++E+ T++ N+K Q +NE S +++ ++IE+ + L +
Sbjct: 929 LKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQ 988
Query: 154 ITEM-NKQISLLTSAVNHLKANVKSAADLISLPTTVEGLQKSVASIGNTLNSVHLAVEAL 212
TE+ NK LT A L A + + L E Q++ + + + A
Sbjct: 989 KTELENKLQQQLTQAAQELAAEKEK---ISVLQNNYEKSQETFKQLQSDFYGRESELLAT 1045
Query: 213 QKTVDEHKKTMELLQSDMNQHFLKETPGSNQIIPSPSATSELDNKTHSENLKQDILYLHN 272
++ + ++ + L Q D+ NQI EL KT L+QD
Sbjct: 1046 RQDLKSVEEKLSLAQEDL-------ISNRNQIGNQNKLIQEL--KTAKATLEQDSAKKEQ 1096
Query: 273 SLEEVNSALVGYQRQNDLK-LEGMNETVSNLTQRVNLIESDVVAMSKVEKKANLSFSMMG 331
L+E AL Q++ LK E +NE +S + + +++ + + +
Sbjct: 1097 QLQERCKALQDIQKEKSLKEKELVNE------------KSKLAEIEEIKCRQEKEITKLN 1144
Query: 332 DRSATLKRQSLDQVTNRTDT------VKIQSIKKEDSSNSQVSKLREKLQLISALTNKPE 385
+ + K +S+ ++TN D K++ K DS + V + + Q++ K E
Sbjct: 1145 EELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEE 1204
Query: 386 SNRPPETADEE 396
E ++E
Sbjct: 1205 EELKKEFIEKE 1215
Score = 45.4 bits (106), Expect = 1e-04
Identities = 55/277 (19%), Positives = 119/277 (42%), Gaps = 24/277 (8%)
Query: 97 ALKEDLDALKEKFRTMESNQKSSFQEIPKLNEE----LLSKQKQLEKIESG-EMGLNKVW 151
AL +L +K+K + + K+S E K N++ +L +K ++++ ++ +
Sbjct: 850 ALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTL 909
Query: 152 INITEMNKQISLLTSAVNHLKANVKSAAD-LISLPTTVEGLQKSVASIGNTLNSVHLAVE 210
E+ K + A + LK + S + LI T++ +K + +N
Sbjct: 910 KEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINE------ 963
Query: 211 ALQKTVDEHKKTMELLQSDMNQHFLKETPGSNQIIPS-PSATSELDNKTHSENLKQDILY 269
L+++ ++ KK +E LQ ++ L++T N++ A EL + K+ I
Sbjct: 964 -LKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAE------KEKISV 1016
Query: 270 LHNSLEEVNSALVGYQRQ---NDLKLEGMNETVSNLTQRVNLIESDVVAMSKVEKKANLS 326
L N+ E+ Q + +L + + ++ ++++L + D+++ N
Sbjct: 1017 LQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKL 1076
Query: 327 FSMMGDRSATLKRQSLDQVTNRTDTVK-IQSIKKEDS 362
+ ATL++ S + + K +Q I+KE S
Sbjct: 1077 IQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKS 1113
Score = 42.0 bits (97), Expect = 0.001
Identities = 68/322 (21%), Positives = 131/322 (40%), Gaps = 51/322 (15%)
Query: 98 LKEDLDALKEKFRTMESNQKSSFQEIPKLNEELLSKQKQL----EKIESGEMGLNKVWIN 153
L+ LD K++ + ++ Q+S+ ++ + +L +Q+ +KI++ E L K N
Sbjct: 479 LQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKEN 538
Query: 154 ITEMNKQISLLTSAVNHLKANVKSAADLISLPTTVEGLQKSVASIGNTLNSVHLAVEALQ 213
I+ + K+ L + + +A A L L LQ+ V + E L+
Sbjct: 539 ISLLEKEREDLYAKI---QAGEGETAVLNQLQEKNHTLQEQVTQL----------TEKLK 585
Query: 214 KTVDEHKKTMELLQSDMNQHFLKETPGSNQIIPSPSATSELDNKTHSENLKQDILYLHNS 273
+ HK+ E L + + K H + +L L S
Sbjct: 586 NQSESHKQAQENLHDQVQEQ-----------------------KAHLRAAQDRVLSLETS 622
Query: 274 LEEVNSALVGYQRQNDLKLEGMNETVSNLTQRVNLIESDVVAMSKVEKKANLSFSMMGDR 333
+ E+NS L N+ K E +++ + + L+ S A K ++A+L + +
Sbjct: 623 VNELNSQL------NESK-EKVSQLDIQIKAKTELLLSAEAA--KTAQRADLQNHLDTAQ 673
Query: 334 SATL-KRQSLDQVTNRTDTVKIQSIKKEDSSNSQVSKLREKLQLISALTNKPES-NRPPE 391
+A K+Q L+++T + D V + K++ + S L+E + +L K E +
Sbjct: 674 NALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIK 733
Query: 392 TADEEQVESFTSKPSALPKFSQ 413
+ + +E SK AL Q
Sbjct: 734 KLEADSLEVKASKEQALQDLQQ 755
Score = 41.2 bits (95), Expect = 0.002
Identities = 58/296 (19%), Positives = 119/296 (40%), Gaps = 14/296 (4%)
Query: 98 LKEDLDALKEKFRTMESNQKSSFQEIPKLNEELLSKQKQLEKIESGEMGLNKVWINITE- 156
LK++ L+ ++ + E+ E+ K +E+ ++L+K++S L + +TE
Sbjct: 251 LKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTEN 310
Query: 157 -MNKQISLLTSAVNHLKANVKS---AADLISLPTTVEGLQKSVASIGNTLNSVHLAVEAL 212
+ K+ H + +V A L + LQ +++ +L+ +H VE
Sbjct: 311 LLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIH--VELS 368
Query: 213 QKTVDEHKKTMELLQSDMNQHFLKETPGSNQIIPSPSATSELDNKTHSENLKQDILYLHN 272
+K K EL + + LK Q L ++ L +L
Sbjct: 369 EKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETER 428
Query: 273 SLEEVNSALVGYQRQNDLKLEGMNETVSNLTQRVNLIESDVVAMSKVEKKANLSFSMMGD 332
L E + L ++ + KL + V++L +++ +E + KV L +
Sbjct: 429 QLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQL--KEKVTNSTELQHQLDKT 486
Query: 333 RSATLKRQSLDQVTNRTDTVKIQSIKKE-DSSNSQVSKLREKLQLISALTNKPESN 387
+ ++Q+L Q T T K++ + + + Q+ +K+Q + AL K + N
Sbjct: 487 KQQHQEQQALQQST----TAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKEN 538
Score = 32.0 bits (71), Expect = 1.3
Identities = 33/144 (22%), Positives = 68/144 (47%), Gaps = 6/144 (4%)
Query: 91 LVWMQVALKEDLDALKEKFRTMESNQKSSFQEIPKLNEEL----LSKQKQL-EKIESGEM 145
L+ ++ L+ D+LK + NQ+ ++ K EEL + K+ +L +I+ E+
Sbjct: 1168 LIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEV 1227
Query: 146 GLNKVWINITEMNKQISLLTSAVNHLKANVKSAADLIS-LPTTVEGLQKSVASIGNTLNS 204
G+ K N ++ QI+ L + +K +S+ +S L + L+ +A + T+ +
Sbjct: 1228 GMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQN 1287
Query: 205 VHLAVEALQKTVDEHKKTMELLQS 228
AL + + + +E LQ+
Sbjct: 1288 NQDERRALLERCLKGEGEIEKLQT 1311
>gi|50083279 centrosome protein 4 [Homo sapiens]
Length = 1140
Score = 47.8 bits (112), Expect = 2e-05
Identities = 64/305 (20%), Positives = 128/305 (41%), Gaps = 33/305 (10%)
Query: 97 ALKEDLDALKEKFRTMESNQKSSFQEIPKLNEELLSKQKQLEKI--------ESGEMGLN 148
+L+ LDA ++ + +++ +F+E +L ++L + ++ ++I + E +
Sbjct: 794 SLRRQLDAAHKELDEVGRSREIAFKENRRLQDDLATMARENQEISLELEAAVQEKEEMKS 853
Query: 149 KVWINITEMNKQISLLTSAVNHLKANVKSAADLIS----LPTTVEGLQKSVASIGNTLNS 204
+V ITE+++ SL+ A K DL+ L E + +S
Sbjct: 854 RVHKYITEVSRWESLMA-------AKEKENQDLLDRFQMLHNRAEDWEVKAHQAEGESSS 906
Query: 205 VHLAVEALQKTVDEHKKTMELLQSDMNQHFLKETPGSNQIIPSPSATSELDNK-THSENL 263
V L + ++ ++ +ELL+ ++ +H +QI A S L+ + H E+
Sbjct: 907 VRLELLSIDTERRHLRERVELLEKEIQEHINAHHAYESQISSMAKAMSRLEEELRHQEDE 966
Query: 264 KQDILYLHNSLEEVNSALVGYQRQNDLKLEGMNETVSNLTQRVNLIESDVVAMSKVEKKA 323
K +L N L + + D+ + +N NL E VV + V+ ++
Sbjct: 967 KATVL---NDLSSLRELCIKLDSGKDIMTQQLNS--KNLE-----FERVVVELENVKSES 1016
Query: 324 NLSFSMMGDRSATLKRQSLDQVTNRTDTVKIQSIKKEDSSNSQVSKLREKLQLI-SALTN 382
+L + + T+K TNR + S ++++ L+EKL L S LT+
Sbjct: 1017 DLLKKQLSNERHTVKNLESLLATNRDK--EFHSHLTSHEKDTEIQLLKEKLTLSESKLTS 1074
Query: 383 KPESN 387
+ N
Sbjct: 1075 QSREN 1079
Score = 36.2 bits (82), Expect = 0.070
Identities = 57/275 (20%), Positives = 116/275 (42%), Gaps = 30/275 (10%)
Query: 99 KEDLDAL-KEKFRT---------MESNQKSSFQEIPKLNEELLSKQKQLEKIES----GE 144
+E+L AL KE +T ME ++ + ++ ++ E + +++LE IE G+
Sbjct: 544 QEELSALRKESTQTTAPHNIVSLMEKEKELALSDLRRIMAEKEALREKLEHIEEVSLFGK 603
Query: 145 MGLNKVWINITEMNKQISL----LTSAVNHLKANVKSAADLISLPTTVEGLQKSVASIGN 200
L K ++T +N Q+ L S V +K ++S + + + +S
Sbjct: 604 SELEKTIEHLTCVNHQLESEKYELKSKVLIMKETIESLENKLKVQAQKFSHVAGDSSHQK 663
Query: 201 T-LNSVHLAVEALQKTVDEHKKTMELLQSDMNQHFLKETPGSNQIIPSPSATSELDNKTH 259
T +NS+ + E LQ++VD+++ + + + ++ QI EL+ K
Sbjct: 664 TEVNSLRIVNEQLQRSVDDYQHRLSIKRGELES-------AQAQIKILEEKIDELNLKMT 716
Query: 260 SENLKQDILYLHNSLEEVNSALVGYQRQNDLKLEGMNETVSNLTQRVNLIESDVVAMSKV 319
S++ ++ + ++ ++ Q D K E + NL + + + +S+
Sbjct: 717 SQD--EEAHVMKKTIGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAVAQMKIMISEC 774
Query: 320 EKKAN-LSFSMMG-DRSATLKRQSLDQVTNRTDTV 352
E N L +++ DR R+ LD D V
Sbjct: 775 ESSVNQLKETLVNRDREINSLRRQLDAAHKELDEV 809
Score = 30.4 bits (67), Expect = 3.9
Identities = 55/293 (18%), Positives = 115/293 (39%), Gaps = 40/293 (13%)
Query: 121 QEIPKLNEELLSKQKQLEKIES--GEMGLNKVWINIT---EMNKQISLLTSAVNHLKANV 175
++I +LN ++ S+ ++ ++ G + K ++ T + K +L + N KA
Sbjct: 706 EKIDELNLKMTSQDEEAHVMKKTIGVIDKEKDFLQETVDEKTEKIANLQENLANKEKAVA 765
Query: 176 KSAADLISLPTTVEGLQKSVASIGNTLNSVHLAVEALQKTVDEHKKTMEL-------LQS 228
+ + ++V L++++ + +NS+ ++A K +DE ++ E+ LQ
Sbjct: 766 QMKIMISECESSVNQLKETLVNRDREINSLRRQLDAAHKELDEVGRSREIAFKENRRLQD 825
Query: 229 DMNQHFLKETPGSNQIIPSPSATSELDNKTH---------------SENLKQDIL----Y 269
D+ + S ++ + E+ ++ H E QD+L
Sbjct: 826 DLATMARENQEISLELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKENQDLLDRFQM 885
Query: 270 LHNSLE--EVNS-ALVGYQRQNDLKLEGMNETVSNLTQRVNLIESDVVAMSKVEKKANLS 326
LHN E EV + G L+L ++ +L +RV L+E ++
Sbjct: 886 LHNRAEDWEVKAHQAEGESSSVRLELLSIDTERRHLRERVELLEKEIQEHINAHHAYESQ 945
Query: 327 FSMMGDRSATLKRQSLDQ------VTNRTDTVKIQSIKKEDSSNSQVSKLREK 373
S M + L+ + Q V N +++ IK + + +L K
Sbjct: 946 ISSMAKAMSRLEEELRHQEDEKATVLNDLSSLRELCIKLDSGKDIMTQQLNSK 998
>gi|27597085 tropomyosin 1 alpha chain isoform 5 [Homo sapiens]
Length = 284
Score = 47.4 bits (111), Expect = 3e-05
Identities = 58/279 (20%), Positives = 123/279 (44%), Gaps = 32/279 (11%)
Query: 98 LKEDLDALKEKFRTMESNQKSSFQEIPKLNEELLSKQKQLEKIESGEMGLNKVWINITEM 157
LK D + ++ E+++K++ +L +EL+S QK+L+ E E+
Sbjct: 11 LKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTED-------------EL 57
Query: 158 NKQISLLTSAVNHLKANVKSA----ADLISLPTTVEGLQKSVASIGNTLNSVHLAVEALQ 213
+K L A L+ K A AD+ SL ++ +++ + L + +E +
Sbjct: 58 DKYSEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAE 117
Query: 214 KTVDEHKKTMELLQSDMNQHFLKETPGSNQIIPSPSATSELDNKTHSENLKQDILYLHNS 273
K DE ++ M++++S + K Q+ + + D K E + + ++ + +
Sbjct: 118 KAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRK--YEEVARKLVIIESD 175
Query: 274 LEEVNSAL---VGYQRQNDLKLEGMNETVSNL-------TQRVNLIESDVVAMSKVEKKA 323
LE G RQ + +L M++T+ L +Q+ + E ++ +S K+A
Sbjct: 176 LERAEERAELSEGQVRQLEEQLRIMDQTLKALMAAEDKYSQKEDRYEEEIKVLSDKLKEA 235
Query: 324 NLSFSMMGDRSATLKRQSLDQVTNR--TDTVKIQSIKKE 360
+ + +RS T +S+D + + +K ++I +E
Sbjct: 236 E-TRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEE 273
>gi|109659847 filamin A interacting protein 1-like isoform 3 [Homo
sapiens]
Length = 1133
Score = 47.4 bits (111), Expect = 3e-05
Identities = 76/382 (19%), Positives = 150/382 (39%), Gaps = 52/382 (13%)
Query: 99 KEDLDALKEKFRTMESNQKSSFQEIPKLNEELL---SKQKQLEKIESGEMGLNKVWINIT 155
+E+L +KEK E E+ +L + +L K ++L K+E LNK T
Sbjct: 348 EEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERET 407
Query: 156 EMNKQISL----LTSAVNHLK----ANVKSAADLISLPTTVEGLQKSVASIGNTLNSVHL 207
+K L L+ + L+ A KS + SL +E + + + L S+ +
Sbjct: 408 LQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKV 467
Query: 208 AVEALQKTVDEHKKTMELLQSDMNQ----------------HFLKETPGSNQIIPSPSAT 251
++ L+ +KT L+ D+ + LK+T Q S
Sbjct: 468 RIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQV 527
Query: 252 SELDNKTHSENLKQDILYLHNSLEEVNSALVGYQRQND---LKLEGMNETVSNLTQRVNL 308
+ T +E L ++ S +V + ++ D KL+ E ++L RVN+
Sbjct: 528 EQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNM 587
Query: 309 IESDVVAMSKVEKKANLSFSMMGDRSATLKRQSLDQVTNRTDTVKIQSIKKEDSSNSQVS 368
+++ + ++ +EK + L+Q + ++ T Q K + +V
Sbjct: 588 LKNRLQSLEAIEK--------------DFLKNKLNQDSGKSTTALHQENNKIKELSQEVE 633
Query: 369 KLREKLQLISALTNKPESNRPPETADEEQVESFTSKPSALPKFSQFLGDPVEKA-AQLRP 427
+L+ KL+ + A+ + E++ E+ + + +QFL +E +L
Sbjct: 634 RLKLKLKDMKAIEDDLMKT-------EDEYETLERRYANERDKAQFLSKELEHVKMELAK 686
Query: 428 ISLPGVSSTEDLQDLFRKTGQD 449
L + T Q LF++ ++
Sbjct: 687 YKLAEKTETSHEQWLFKRLQEE 708
Score = 34.3 bits (77), Expect = 0.27
Identities = 68/354 (19%), Positives = 138/354 (38%), Gaps = 41/354 (11%)
Query: 95 QVALKEDLDALKEKFRTMESNQKSSFQEIPKLNEELLSKQKQLEKIESGEMGLNKVWI-- 152
+ LKEDL LK +K+ +++ K ++L + QL+ ++ + + I
Sbjct: 483 EFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEE 542
Query: 153 ------NITEMNKQISLLT----SAVNHLKANVKSAADLISLPTTVEGLQKSVASIGNTL 202
+ T++ +++ +T N LKA + DL+S ++ +S+ +I
Sbjct: 543 TKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDF 602
Query: 203 NSVHLAVEALQKTVDEHKKTMELLQSDMNQHFLKETPGSNQIIPSPSATSELDNKT---H 259
L ++ + T H++ ++ + LK + I +E + +T
Sbjct: 603 LKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERR 662
Query: 260 SENLKQDILYLHNSLEEVNSALVGYQRQNDL----------KLEGMNETVSNLTQRVNLI 309
N + +L LE V L Y+ +L+ +L++ V+ +
Sbjct: 663 YANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDAL 722
Query: 310 ESDVVAMSKVEKKANLSFSMMGDRSATLKRQSLDQVTNRTDTVKIQSIKKEDSSNSQVSK 369
+ + E +L + GD S K+ + + NR +I+++ KE SK
Sbjct: 723 KEKIHEYMATE---DLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSK 779
Query: 370 -LREKLQLISALTNKPESNRPPETADEEQVESFTSKPSALPKFSQFLGDPVEKA 422
LR L N + P + E Q E+ ++P P + + P+E+A
Sbjct: 780 SLRPSL-------NGRRISDPQVFSKEVQTEAVDNEP---PDYKSLI--PLERA 821
>gi|109659849 filamin A interacting protein 1-like isoform 2 [Homo
sapiens]
Length = 893
Score = 47.4 bits (111), Expect = 3e-05
Identities = 76/382 (19%), Positives = 150/382 (39%), Gaps = 52/382 (13%)
Query: 99 KEDLDALKEKFRTMESNQKSSFQEIPKLNEELL---SKQKQLEKIESGEMGLNKVWINIT 155
+E+L +KEK E E+ +L + +L K ++L K+E LNK T
Sbjct: 108 EEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERET 167
Query: 156 EMNKQISL----LTSAVNHLK----ANVKSAADLISLPTTVEGLQKSVASIGNTLNSVHL 207
+K L L+ + L+ A KS + SL +E + + + L S+ +
Sbjct: 168 LQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKV 227
Query: 208 AVEALQKTVDEHKKTMELLQSDMNQ----------------HFLKETPGSNQIIPSPSAT 251
++ L+ +KT L+ D+ + LK+T Q S
Sbjct: 228 RIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQV 287
Query: 252 SELDNKTHSENLKQDILYLHNSLEEVNSALVGYQRQND---LKLEGMNETVSNLTQRVNL 308
+ T +E L ++ S +V + ++ D KL+ E ++L RVN+
Sbjct: 288 EQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNM 347
Query: 309 IESDVVAMSKVEKKANLSFSMMGDRSATLKRQSLDQVTNRTDTVKIQSIKKEDSSNSQVS 368
+++ + ++ +EK + L+Q + ++ T Q K + +V
Sbjct: 348 LKNRLQSLEAIEK--------------DFLKNKLNQDSGKSTTALHQENNKIKELSQEVE 393
Query: 369 KLREKLQLISALTNKPESNRPPETADEEQVESFTSKPSALPKFSQFLGDPVEKA-AQLRP 427
+L+ KL+ + A+ + E++ E+ + + +QFL +E +L
Sbjct: 394 RLKLKLKDMKAIEDDLMKT-------EDEYETLERRYANERDKAQFLSKELEHVKMELAK 446
Query: 428 ISLPGVSSTEDLQDLFRKTGQD 449
L + T Q LF++ ++
Sbjct: 447 YKLAEKTETSHEQWLFKRLQEE 468
Score = 34.3 bits (77), Expect = 0.27
Identities = 68/354 (19%), Positives = 138/354 (38%), Gaps = 41/354 (11%)
Query: 95 QVALKEDLDALKEKFRTMESNQKSSFQEIPKLNEELLSKQKQLEKIESGEMGLNKVWI-- 152
+ LKEDL LK +K+ +++ K ++L + QL+ ++ + + I
Sbjct: 243 EFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEE 302
Query: 153 ------NITEMNKQISLLT----SAVNHLKANVKSAADLISLPTTVEGLQKSVASIGNTL 202
+ T++ +++ +T N LKA + DL+S ++ +S+ +I
Sbjct: 303 TKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDF 362
Query: 203 NSVHLAVEALQKTVDEHKKTMELLQSDMNQHFLKETPGSNQIIPSPSATSELDNKT---H 259
L ++ + T H++ ++ + LK + I +E + +T
Sbjct: 363 LKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERR 422
Query: 260 SENLKQDILYLHNSLEEVNSALVGYQRQNDL----------KLEGMNETVSNLTQRVNLI 309
N + +L LE V L Y+ +L+ +L++ V+ +
Sbjct: 423 YANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDAL 482
Query: 310 ESDVVAMSKVEKKANLSFSMMGDRSATLKRQSLDQVTNRTDTVKIQSIKKEDSSNSQVSK 369
+ + E +L + GD S K+ + + NR +I+++ KE SK
Sbjct: 483 KEKIHEYMATE---DLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSK 539
Query: 370 -LREKLQLISALTNKPESNRPPETADEEQVESFTSKPSALPKFSQFLGDPVEKA 422
LR L N + P + E Q E+ ++P P + + P+E+A
Sbjct: 540 SLRPSL-------NGRRISDPQVFSKEVQTEAVDNEP---PDYKSLI--PLERA 581
>gi|109659845 filamin A interacting protein 1-like isoform 1 [Homo
sapiens]
Length = 1135
Score = 47.4 bits (111), Expect = 3e-05
Identities = 76/382 (19%), Positives = 150/382 (39%), Gaps = 52/382 (13%)
Query: 99 KEDLDALKEKFRTMESNQKSSFQEIPKLNEELL---SKQKQLEKIESGEMGLNKVWINIT 155
+E+L +KEK E E+ +L + +L K ++L K+E LNK T
Sbjct: 348 EEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERET 407
Query: 156 EMNKQISL----LTSAVNHLK----ANVKSAADLISLPTTVEGLQKSVASIGNTLNSVHL 207
+K L L+ + L+ A KS + SL +E + + + L S+ +
Sbjct: 408 LQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKV 467
Query: 208 AVEALQKTVDEHKKTMELLQSDMNQ----------------HFLKETPGSNQIIPSPSAT 251
++ L+ +KT L+ D+ + LK+T Q S
Sbjct: 468 RIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQV 527
Query: 252 SELDNKTHSENLKQDILYLHNSLEEVNSALVGYQRQND---LKLEGMNETVSNLTQRVNL 308
+ T +E L ++ S +V + ++ D KL+ E ++L RVN+
Sbjct: 528 EQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNM 587
Query: 309 IESDVVAMSKVEKKANLSFSMMGDRSATLKRQSLDQVTNRTDTVKIQSIKKEDSSNSQVS 368
+++ + ++ +EK + L+Q + ++ T Q K + +V
Sbjct: 588 LKNRLQSLEAIEK--------------DFLKNKLNQDSGKSTTALHQENNKIKELSQEVE 633
Query: 369 KLREKLQLISALTNKPESNRPPETADEEQVESFTSKPSALPKFSQFLGDPVEKA-AQLRP 427
+L+ KL+ + A+ + E++ E+ + + +QFL +E +L
Sbjct: 634 RLKLKLKDMKAIEDDLMKT-------EDEYETLERRYANERDKAQFLSKELEHVKMELAK 686
Query: 428 ISLPGVSSTEDLQDLFRKTGQD 449
L + T Q LF++ ++
Sbjct: 687 YKLAEKTETSHEQWLFKRLQEE 708
Score = 34.3 bits (77), Expect = 0.27
Identities = 68/354 (19%), Positives = 138/354 (38%), Gaps = 41/354 (11%)
Query: 95 QVALKEDLDALKEKFRTMESNQKSSFQEIPKLNEELLSKQKQLEKIESGEMGLNKVWI-- 152
+ LKEDL LK +K+ +++ K ++L + QL+ ++ + + I
Sbjct: 483 EFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEE 542
Query: 153 ------NITEMNKQISLLT----SAVNHLKANVKSAADLISLPTTVEGLQKSVASIGNTL 202
+ T++ +++ +T N LKA + DL+S ++ +S+ +I
Sbjct: 543 TKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDF 602
Query: 203 NSVHLAVEALQKTVDEHKKTMELLQSDMNQHFLKETPGSNQIIPSPSATSELDNKT---H 259
L ++ + T H++ ++ + LK + I +E + +T
Sbjct: 603 LKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERR 662
Query: 260 SENLKQDILYLHNSLEEVNSALVGYQRQNDL----------KLEGMNETVSNLTQRVNLI 309
N + +L LE V L Y+ +L+ +L++ V+ +
Sbjct: 663 YANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDAL 722
Query: 310 ESDVVAMSKVEKKANLSFSMMGDRSATLKRQSLDQVTNRTDTVKIQSIKKEDSSNSQVSK 369
+ + E +L + GD S K+ + + NR +I+++ KE SK
Sbjct: 723 KEKIHEYMATE---DLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSK 779
Query: 370 -LREKLQLISALTNKPESNRPPETADEEQVESFTSKPSALPKFSQFLGDPVEKA 422
LR L N + P + E Q E+ ++P P + + P+E+A
Sbjct: 780 SLRPSL-------NGRRISDPQVFSKEVQTEAVDNEP---PDYKSLI--PLERA 821
>gi|237858621 polyamine modulated factor 1 binding protein 1 isoform
b [Homo sapiens]
Length = 882
Score = 47.0 bits (110), Expect = 4e-05
Identities = 79/333 (23%), Positives = 147/333 (44%), Gaps = 49/333 (14%)
Query: 98 LKEDLDALKEKFR----TMESNQKSSFQEIPKLNEELLSKQKQLEKIESGEMGLNKVWIN 153
++ +L+AL+++F+ T++ N + +E L EL QLE LNK +
Sbjct: 488 MEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLES------SLNKYNTS 541
Query: 154 ---ITEMNKQISLLTSAVNHLKANVKSA--ADLISLPTTV-----EGLQKSVASIGNTLN 203
I ++NK+I+L ++ L+A + A + L TT+ + L + A+ + L
Sbjct: 542 QQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLT 601
Query: 204 SVHLAVEALQKTVDEHKKTMELLQSDMNQHFLKETPGSNQIIPSPSATSELDNKT----- 258
A+E L E K LQ + Q K+ +II +L+ +
Sbjct: 602 Q---ALEKLNHVTSETKS----LQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRG 654
Query: 259 -HSENLKQDILYLHNSLEEVNSALVGYQR--QNDLK-LEGMNETVSNLTQRVNLIESDVV 314
H E+ + ++ LEE++ ++ +Q+ QNDLK L E + + + ++ +++
Sbjct: 655 FHQES-ELEVHAFDKKLEEMSCQVLQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLL 713
Query: 315 AMSKVEKKANLSFSMMGDRSATLKRQSLDQVTNRTDTVKIQSIKKEDSSNSQVSKLREKL 374
K E +S+ D + L R + +TN K Q + E N +LRE++
Sbjct: 714 EDDK-EPCCLPQWSVPKD-TCRLYRGNDQIMTNLEQWAKQQKVANEKLGN----QLREQV 767
Query: 375 QLISALTNKPESNRPPETADEEQVESFTSKPSA 407
+ I+ L+ E +R P A T++PS+
Sbjct: 768 KYIAKLSG--EKDREPTRASSPN----TTRPSS 794
>gi|187761324 shootin1 isoform a [Homo sapiens]
Length = 631
Score = 46.6 bits (109), Expect = 5e-05
Identities = 76/339 (22%), Positives = 135/339 (39%), Gaps = 66/339 (19%)
Query: 101 DLDALKEKFRTMESNQKSSFQEIPKLNEELLSKQKQLEKIESGEMGLNKVWINITEMNKQ 160
+L+ LK K + QE LN E+L ++K LEK N+V + E ++
Sbjct: 164 ELENLKSKLVEVIEEVNKVKQEKTVLNSEVLEQRKVLEK-------CNRVSMLAVEEYEE 216
Query: 161 ISLLTSAVNHLKANVKSAADLISLPTTVEGLQKSVASIGNTLNSVHLAVEALQKTVDEHK 220
+ + L+ +S A + + Q + + L + + L K +DE+
Sbjct: 217 MQVNLELEKDLRKKAESFAQEMFIE------QNKLKRQSHLLLQSSIPDQQLLKALDENA 270
Query: 221 KTMELLQSDMNQHFLKETPGSNQIIPSPSATSELDNKT-HSE--NLKQDILYLHNSLEEV 277
K + L+ + QH K +L+N+T H E NLKQ + L +E+
Sbjct: 271 KLTQQLEEERIQHQQK----------VKELEEQLENETLHKEIHNLKQQLELLEEDKKEL 320
Query: 278 NSALVGYQRQNDLKLEGMNETVSNLTQRVNLIESDV-------------------VAMSK 318
+ YQ + K + +V L +RVN E+ V MS
Sbjct: 321 E---LKYQNSEE-KARNLKHSVDELQKRVNQSENSVPPPPPPPPPLPPPPPNPIRSLMSM 376
Query: 319 VEKKANLSFSMMGDRSAT----------LKRQSLDQVTNRTDT-VKIQSI------KKED 361
+ K+++ S S AT LKRQ+++++ +R V ++ + K +
Sbjct: 377 IRKRSHPSGSGAKKEKATQPETTEEVTDLKRQAVEEMMDRIKKGVHLRPVNQTARPKTKP 436
Query: 362 SSNSQVSKLREKLQLISALTNKPESNRPPETADEEQVES 400
S+ ++L+ I NK S+R ++ D E E+
Sbjct: 437 ESSKGCESAVDELKGILGTLNKSTSSRSLKSLDPENSET 475
>gi|148762940 DVL-binding protein DAPLE [Homo sapiens]
Length = 2028
Score = 46.6 bits (109), Expect = 5e-05
Identities = 73/353 (20%), Positives = 153/353 (43%), Gaps = 53/353 (15%)
Query: 107 EKFRTMESNQKSSFQEIPKLNEELLSKQKQLEKIESGEMGLNKVWINITEMNKQISLLTS 166
EK +T +K S Q++ L+EEL+ +++QL+ +M K + +QI L
Sbjct: 511 EKLQTQLEREKQSNQDLETLSEELIREKEQLQ----SDMETLK-----ADKARQIKDLEQ 561
Query: 167 AVNHL---------KANVKSAADLISLPTTVEGLQKSVASIGNTLNSVHLAVEALQKTVD 217
+HL ++ V S A + + + L ++V L+ + L + ++
Sbjct: 562 EKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEANGKLSQLEFEKRQLHRDLE 621
Query: 218 EHKKTMELLQS-DMNQHFLKETPG--SNQIIPSPSATSELDNKTH-SENLKQDILYLHNS 273
+ K+ E + + L+E G + ++ +AT +++ H S+ L+ + L S
Sbjct: 622 QAKEKGERAEKLERELQRLQEENGRLARKVTSLETATEKVEALEHESQGLQLENRTLRKS 681
Query: 274 ---LEEVNSALVGYQRQN------DLKLEGMNETVSNLTQRVNLIESD------------ 312
L+ V+ L G +R N +L+L + ET+ + ++ +E +
Sbjct: 682 LDTLQNVSLQLEGLERDNKQLDAENLELRRLVETMRFTSTKLAQMERENQQLEREKEELR 741
Query: 313 -----VVAMSKVEKKANLSFSMMGDRSATLKRQSLDQVTNRTDTVKIQSIKKEDSSNSQV 367
+ A+ K ++ LS+ + + L +QSL+ +++T T++ + + ++ +
Sbjct: 742 KNVDLLKALGKKSERLELSYQSVSAENLRL-QQSLESSSHKTQTLE-SELGELEAERQAL 799
Query: 368 SKLREKLQLISALTNKPESNRPPETADEEQVESFTSKPSALPKFSQFLGDPVE 420
+ E L+L +A E +R A E++V L K ++ L VE
Sbjct: 800 RRDLEALRLANAQLEGAEKDR---KALEQEVAQLEKDKKLLEKEAKRLWQQVE 849
>gi|63252906 tropomyosin 1 alpha chain isoform 7 [Homo sapiens]
Length = 284
Score = 45.8 bits (107), Expect = 9e-05
Identities = 57/280 (20%), Positives = 125/280 (44%), Gaps = 27/280 (9%)
Query: 98 LKEDLDALKEKFRTMESNQKSSFQEIPKLNEELLSKQKQLEKIESGEMGLNKVWINITEM 157
LK D + ++ E+++K++ +L E++ +K+K L E + + E+
Sbjct: 11 LKLDKENALDRAEQAEADKKAAEDRSKQLEEDIAAKEKLLRVSEDERDRV------LEEL 64
Query: 158 NKQISLLTSAVNHLKANVKSAADLISLPTTVEGLQKSVASIGNTLNSVHLAVEALQKTVD 217
+K L +A +A K+ AD+ SL ++ +++ + L + +E +K D
Sbjct: 65 HKAEDSLLAAE---EAAAKAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAAD 121
Query: 218 EHKKTMELLQSDMNQHFLKETPGSNQIIPSPSATSELDNKTHSENLKQDILYLHNSLEEV 277
E ++ M++++S + K Q+ + + D K E + + ++ + + LE
Sbjct: 122 ESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRK--YEEVARKLVIIESDLERA 179
Query: 278 NSAL---VGYQRQNDLKLEGMNETVSNL-------TQRVNLIESDVVAMSKVEKKANLSF 327
G RQ + +L M++T+ L +Q+ + E ++ +S K+A +
Sbjct: 180 EERAELSEGQVRQLEEQLRIMDQTLKALMAAEDKYSQKEDRYEEEIKVLSDKLKEAE-TR 238
Query: 328 SMMGDRSATLKRQSLDQVTNRTDTVKIQSIKKEDSSNSQV 367
+ +RS T +S+D + K+ K+E+ S Q+
Sbjct: 239 AEFAERSVTKLEKSIDDLEE-----KVAHAKEENLSMHQM 273
>gi|70166430 GRINL1A combined protein isoform 2 [Homo sapiens]
Length = 445
Score = 45.1 bits (105), Expect = 2e-04
Identities = 62/310 (20%), Positives = 128/310 (41%), Gaps = 40/310 (12%)
Query: 93 WMQVALKEDLDALKEKFRTMESNQKSSF-------QEIPKLNEELLSKQKQLEKIESGEM 145
W LKE+++ +K+ T+E +K + Q+I +L +EL Q E +E+
Sbjct: 92 WSTSQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLEN--- 148
Query: 146 GLNKVWINITEMNKQISLLTSAVNHLKA-NVKSAADLISLPTTVEGLQKSVASIGNTLNS 204
I +SA++ A N A+D I L T+ + ++I + + +
Sbjct: 149 --------------HIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRN 194
Query: 205 VHLAVEALQKTVDEHKKTMELLQSDMNQHFLKETPGSNQIIPSPSATSELDNKTHS--EN 262
+ EA + E ++ +E+ Q + NQ + S + + E+ K +S E
Sbjct: 195 LQQTYEASMDKLREKQRQLEVAQVE-NQLLKMKVESSQE--ANAEVMREMTKKLYSQYEE 251
Query: 263 LKQDILYLHNS-----LEEVNSALVGYQRQNDLKLEGMNETVSNLTQRVNLIESDVVAMS 317
Q+ H++ LEE NS L + N K++ ++ QR+ ++ + M
Sbjct: 252 KLQEEQRKHSAEKEALLEETNSFLKAIEEANK-KMQAAEISLEEKDQRIGELDRLIERME 310
Query: 318 KVEKKANLSF----SMMGDRSATLKRQSLDQVTNRTDTVKIQSIKKEDSSNSQVSKLREK 373
K + L + M ++ Q+ + +++ + +D + Q K+++
Sbjct: 311 KERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQM 370
Query: 374 LQLISALTNK 383
++ I +L K
Sbjct: 371 VEEIESLKKK 380
>gi|70166414 GRINL1A combined protein isoform 1 [Homo sapiens]
Length = 550
Score = 45.1 bits (105), Expect = 2e-04
Identities = 62/310 (20%), Positives = 128/310 (41%), Gaps = 40/310 (12%)
Query: 93 WMQVALKEDLDALKEKFRTMESNQKSSF-------QEIPKLNEELLSKQKQLEKIESGEM 145
W LKE+++ +K+ T+E +K + Q+I +L +EL Q E +E+
Sbjct: 92 WSTSQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLEN--- 148
Query: 146 GLNKVWINITEMNKQISLLTSAVNHLKA-NVKSAADLISLPTTVEGLQKSVASIGNTLNS 204
I +SA++ A N A+D I L T+ + ++I + + +
Sbjct: 149 --------------HIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRN 194
Query: 205 VHLAVEALQKTVDEHKKTMELLQSDMNQHFLKETPGSNQIIPSPSATSELDNKTHS--EN 262
+ EA + E ++ +E+ Q + NQ + S + + E+ K +S E
Sbjct: 195 LQQTYEASMDKLREKQRQLEVAQVE-NQLLKMKVESSQE--ANAEVMREMTKKLYSQYEE 251
Query: 263 LKQDILYLHNS-----LEEVNSALVGYQRQNDLKLEGMNETVSNLTQRVNLIESDVVAMS 317
Q+ H++ LEE NS L + N K++ ++ QR+ ++ + M
Sbjct: 252 KLQEEQRKHSAEKEALLEETNSFLKAIEEANK-KMQAAEISLEEKDQRIGELDRLIERME 310
Query: 318 KVEKKANLSF----SMMGDRSATLKRQSLDQVTNRTDTVKIQSIKKEDSSNSQVSKLREK 373
K + L + M ++ Q+ + +++ + +D + Q K+++
Sbjct: 311 KERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQM 370
Query: 374 LQLISALTNK 383
++ I +L K
Sbjct: 371 VEEIESLKKK 380
>gi|70166580 GRINL1A upstream protein isoform 7 [Homo sapiens]
Length = 466
Score = 45.1 bits (105), Expect = 2e-04
Identities = 62/310 (20%), Positives = 128/310 (41%), Gaps = 40/310 (12%)
Query: 93 WMQVALKEDLDALKEKFRTMESNQKSSF-------QEIPKLNEELLSKQKQLEKIESGEM 145
W LKE+++ +K+ T+E +K + Q+I +L +EL Q E +E+
Sbjct: 92 WSTSQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQELSVSHAQQEYLEN--- 148
Query: 146 GLNKVWINITEMNKQISLLTSAVNHLKA-NVKSAADLISLPTTVEGLQKSVASIGNTLNS 204
I +SA++ A N A+D I L T+ + ++I + + +
Sbjct: 149 --------------HIQTQSSALDRFNAMNSALASDSIGLQKTLVDVTLENSNIKDQIRN 194
Query: 205 VHLAVEALQKTVDEHKKTMELLQSDMNQHFLKETPGSNQIIPSPSATSELDNKTHS--EN 262
+ EA + E ++ +E+ Q + NQ + S + + E+ K +S E
Sbjct: 195 LQQTYEASMDKLREKQRQLEVAQVE-NQLLKMKVESSQE--ANAEVMREMTKKLYSQYEE 251
Query: 263 LKQDILYLHNS-----LEEVNSALVGYQRQNDLKLEGMNETVSNLTQRVNLIESDVVAMS 317
Q+ H++ LEE NS L + N K++ ++ QR+ ++ + M
Sbjct: 252 KLQEEQRKHSAEKEALLEETNSFLKAIEEANK-KMQAAEISLEEKDQRIGELDRLIERME 310
Query: 318 KVEKKANLSF----SMMGDRSATLKRQSLDQVTNRTDTVKIQSIKKEDSSNSQVSKLREK 373
K + L + M ++ Q+ + +++ + +D + Q K+++
Sbjct: 311 KERHQLQLQLLEHETEMSGELTDSDKERYQQLEEASASLRERIRHLDDMVHCQQKKVKQM 370
Query: 374 LQLISALTNK 383
++ I +L K
Sbjct: 371 VEEIESLKKK 380
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.127 0.344
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,883,816
Number of Sequences: 37866
Number of extensions: 788083
Number of successful extensions: 4745
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 19
Number of HSP's successfully gapped in prelim test: 360
Number of HSP's that attempted gapping in prelim test: 4153
Number of HSP's gapped (non-prelim): 873
length of query: 495
length of database: 18,247,518
effective HSP length: 106
effective length of query: 389
effective length of database: 14,233,722
effective search space: 5536917858
effective search space used: 5536917858
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.