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Search of human proteins with 7662070
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7662070 Ral GEF with PH domain and SH3 binding motif 1 [Homo
sapiens]
(557 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7662070 Ral GEF with PH domain and SH3 binding motif 1 [Homo ... 1108 0.0
gi|32441283 Ral GEF with PH domain and SH3 binding motif 2 [Homo... 690 0.0
gi|239582763 ral guanine nucleotide dissociation stimulator-like... 125 1e-28
gi|239582765 ral guanine nucleotide dissociation stimulator-like... 125 1e-28
gi|38505170 Ras protein-specific guanine nucleotide-releasing fa... 123 4e-28
gi|224586880 Ras protein-specific guanine nucleotide-releasing f... 123 5e-28
gi|24797099 Ras protein-specific guanine nucleotide-releasing fa... 123 5e-28
gi|24797101 Ras protein-specific guanine nucleotide-releasing fa... 123 5e-28
gi|24307909 ral guanine nucleotide dissociation stimulator isofo... 119 7e-27
gi|108796058 ral guanine nucleotide dissociation stimulator isof... 119 7e-27
gi|15529996 son of sevenless homolog 1 [Homo sapiens] 113 5e-25
gi|93102367 ral guanine nucleotide dissociation stimulator-like ... 110 3e-24
gi|4758532 ral guanine nucleotide dissociation stimulator-like 2... 102 9e-22
gi|154689780 son of sevenless homolog 2 [Homo sapiens] 101 2e-21
gi|23957680 ral guanine nucleotide dissociation stimulator-like ... 101 2e-21
gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Hom... 98 2e-20
gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Hom... 98 2e-20
gi|155030206 Rap guanine nucleotide exchange factor (GEF) 4 isof... 87 3e-17
gi|155030204 Rap guanine nucleotide exchange factor (GEF) 4 isof... 87 3e-17
gi|119392077 Rap guanine nucleotide exchange factor (GEF) 5 [Hom... 87 3e-17
gi|213385270 RAS guanyl releasing protein 3 (calcium and DAG-reg... 87 4e-17
gi|24762239 RAS guanyl releasing protein 3 (calcium and DAG-regu... 87 4e-17
gi|7662334 RAS guanyl releasing protein 3 (calcium and DAG-regul... 87 5e-17
gi|7657261 Rap guanine nucleotide exchange factor 2 [Homo sapiens] 86 9e-17
gi|7705939 Rap guanine nucleotide exchange factor (GEF)-like 1 [... 84 4e-16
gi|24797103 RAS guanyl releasing protein 2 [Homo sapiens] 82 1e-15
gi|149158729 RAS guanyl releasing protein 2 [Homo sapiens] 82 1e-15
gi|149158727 RAS guanyl releasing protein 2 [Homo sapiens] 82 1e-15
gi|148747862 Rap guanine nucleotide exchange factor 3 isoform b ... 78 2e-14
gi|20070215 Rap guanine nucleotide exchange factor 3 isoform b [... 78 2e-14
>gi|7662070 Ral GEF with PH domain and SH3 binding motif 1 [Homo
sapiens]
Length = 557
Score = 1108 bits (2865), Expect = 0.0
Identities = 557/557 (100%), Positives = 557/557 (100%)
Query: 1 MYKRNGLMASVLVTSATPQGSSSSDSLEGQSCDYASKSYDAVVFDVLKVTPEEFASQITL 60
MYKRNGLMASVLVTSATPQGSSSSDSLEGQSCDYASKSYDAVVFDVLKVTPEEFASQITL
Sbjct: 1 MYKRNGLMASVLVTSATPQGSSSSDSLEGQSCDYASKSYDAVVFDVLKVTPEEFASQITL 60
Query: 61 MDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAFTRRFNQVSFWVVREILTAQTLKIRAE 120
MDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAFTRRFNQVSFWVVREILTAQTLKIRAE
Sbjct: 61 MDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAFTRRFNQVSFWVVREILTAQTLKIRAE 120
Query: 121 ILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFRLTKTWALLNRKDKTTFEKLDYLMSK 180
ILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFRLTKTWALLNRKDKTTFEKLDYLMSK
Sbjct: 121 ILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFRLTKTWALLNRKDKTTFEKLDYLMSK 180
Query: 181 EDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDSAYPASGSIMENEQRSNQMNNILRII 240
EDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDSAYPASGSIMENEQRSNQMNNILRII
Sbjct: 181 EDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDSAYPASGSIMENEQRSNQMNNILRII 240
Query: 241 ADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQKFVEDDNYKLSLRIEPGSSSPRLVSSKE 300
ADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQKFVEDDNYKLSLRIEPGSSSPRLVSSKE
Sbjct: 241 ADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQKFVEDDNYKLSLRIEPGSSSPRLVSSKE 300
Query: 301 DLAGPSAGSGSARFSRRPTCPDTSVAGSLPTPPVPRHRKSHSLGNNMMCQLSVVESKSAT 360
DLAGPSAGSGSARFSRRPTCPDTSVAGSLPTPPVPRHRKSHSLGNNMMCQLSVVESKSAT
Sbjct: 301 DLAGPSAGSGSARFSRRPTCPDTSVAGSLPTPPVPRHRKSHSLGNNMMCQLSVVESKSAT 360
Query: 361 FPSEKARHLLDDSVLESRSPRRGLALTSSSAVTNGLSLGSSESSEFSEEMSSGLESPTGP 420
FPSEKARHLLDDSVLESRSPRRGLALTSSSAVTNGLSLGSSESSEFSEEMSSGLESPTGP
Sbjct: 361 FPSEKARHLLDDSVLESRSPRRGLALTSSSAVTNGLSLGSSESSEFSEEMSSGLESPTGP 420
Query: 421 CICSLGNSAAVPTMEGPLRRKTLLKEGRKPALSSWTRYWVILSGSTLLYYGAKSLRGTDR 480
CICSLGNSAAVPTMEGPLRRKTLLKEGRKPALSSWTRYWVILSGSTLLYYGAKSLRGTDR
Sbjct: 421 CICSLGNSAAVPTMEGPLRRKTLLKEGRKPALSSWTRYWVILSGSTLLYYGAKSLRGTDR 480
Query: 481 KHYKSTPGKKVSIVGWMVQLPDDPEHPDIFQLNNPDKGNVYKFQTGSRFHAILWHKHLDD 540
KHYKSTPGKKVSIVGWMVQLPDDPEHPDIFQLNNPDKGNVYKFQTGSRFHAILWHKHLDD
Sbjct: 481 KHYKSTPGKKVSIVGWMVQLPDDPEHPDIFQLNNPDKGNVYKFQTGSRFHAILWHKHLDD 540
Query: 541 ACKSNRPQVPANLMSFE 557
ACKSNRPQVPANLMSFE
Sbjct: 541 ACKSNRPQVPANLMSFE 557
>gi|32441283 Ral GEF with PH domain and SH3 binding motif 2 [Homo
sapiens]
Length = 583
Score = 690 bits (1780), Expect = 0.0
Identities = 361/587 (61%), Positives = 437/587 (74%), Gaps = 42/587 (7%)
Query: 5 NGLMASVLVTSATPQGSSSSDSLEGQSCDYASKSYDAVVFDVLKVTPEEFASQITLMDIP 64
NG +SV + + + SSSS+SL + + KS+DAVVFDVLKVTPEE+A QITLMD+P
Sbjct: 5 NGQASSVNIAATASEKSSSSESLSDKGSEL-KKSFDAVVFDVLKVTPEEYAGQITLMDVP 63
Query: 65 VFKAIQPEELASCGWSKKEKHSLAPNVVAFTRRFNQVSFWVVREILTAQTLKIRAEILSH 124
VFKAIQP+EL+SCGW+KKEK+S APN VAFTRRFN VSFWVVREIL AQTLKIRAE+LSH
Sbjct: 64 VFKAIQPDELSSCGWNKKEKYSSAPNAVAFTRRFNHVSFWVVREILHAQTLKIRAEVLSH 123
Query: 125 FVKIAKKLLELNNLHSLMSVVSALQSAPIFRLTKTWALLNRKDKTTFEKLDYLMSKEDNY 184
++K AKKL ELNNLH+LM+VVS LQSAPIFRLTKTWALL+RKDKTTFEKL+Y+MSKEDNY
Sbjct: 124 YIKTAKKLYELNNLHALMAVVSGLQSAPIFRLTKTWALLSRKDKTTFEKLEYVMSKEDNY 183
Query: 185 KRTREYIRSLKMVPSIPYLGIYLLDLIYIDSAYPASGSIMENEQRSNQMNNILRIIADLQ 244
KR R+YI SLKM P IPYLGIYL DL YIDSAYP++GSI+ENEQRSN MNNILRII+DLQ
Sbjct: 184 KRLRDYISSLKMTPCIPYLGIYLSDLTYIDSAYPSTGSILENEQRSNLMNNILRIISDLQ 243
Query: 245 VSCSYDHLTTLPHVQKYLKSVRYIEELQKFVEDDNYKLSLRIEPGSSSPRLVSSKEDLAG 304
SC YD + LPHVQKYL SV+YIEELQKFVEDDNYKLSL+IEPG+S+PR +S+EDL G
Sbjct: 244 QSCEYD-IPMLPHVQKYLNSVQYIEELQKFVEDDNYKLSLKIEPGTSTPRSAASREDLVG 302
Query: 305 PSAGSGSARFSRRPTCPDTSVAGSLP-TPPVPR------HRKSHSLGNNMMCQLSVVESK 357
P G+ S + R+ + ++ LP TPP PR HRK HSLG N + +++ E K
Sbjct: 303 PEVGA-SPQSGRKSVAAEGAL---LPQTPPSPRNLIPHGHRKCHSLGYNFIHKMNTAEFK 358
Query: 358 SATFPSEKARHLLDDSVLESRSPRRGLALTSSSAVTNGLSLGSSESSEFSEEMS------ 411
SATFP+ RHLLDDSV+E +P RG A SS +++G+S+GSS+ SE SEE S
Sbjct: 359 SATFPNAGPRHLLDDSVMEPHAPSRGQA--ESSTLSSGISIGSSDGSELSEETSWPAFER 416
Query: 412 SGLESPTGPCICSLGNS---------------------AAVPTMEGPLRRKTLLKEGRKP 450
+ L GP N T++G LRRKTLLKEG+KP
Sbjct: 417 NRLYHSLGPVTRVARNGYRSHMKASSSAESEDLAVHLYPGAVTIQGVLRRKTLLKEGKKP 476
Query: 451 ALSSWTRYWVILSGSTLLYYGAKSLRGTDRKHYKSTPGKKVSIVGWMVQLPDDPEHPDIF 510
++SWT+YW L G+ L YY AKSL+ T+RKH+KST K VS++GWMV + DDPEHPD+F
Sbjct: 477 TVASWTKYWAALCGTQLFYYAAKSLKATERKHFKSTSNKNVSVIGWMVMMADDPEHPDLF 536
Query: 511 QLNNPDKGNVYKFQTGSRFHAILWHKHLDDACKSNRPQVPANLMSFE 557
L + +KGN YKFQ G+R +A+LW KHL AC+SN+ QVP NLM+FE
Sbjct: 537 LLTDSEKGNSYKFQAGNRMNAMLWFKHLSAACQSNKQQVPTNLMTFE 583
>gi|239582763 ral guanine nucleotide dissociation stimulator-like 3
isoform 2 [Homo sapiens]
Length = 710
Score = 125 bits (314), Expect = 1e-28
Identities = 107/368 (29%), Positives = 177/368 (48%), Gaps = 56/368 (15%)
Query: 13 VTSATPQGSSSSDSLEGQSCDYASKSYDAVVFDVLKVTPEEFASQITLMDIPVFKAIQPE 72
V + P+ + +SD ++C + +L + +E A Q+TL+D+ +F ++
Sbjct: 210 VWTGPPRVAQTSDPDSSEACAEEEEGLMPQGPQLLDFSVDEVAEQLTLIDLELFSKVRLY 269
Query: 73 ELASCGWSKKEKHSLA---PNVVAFTRRFNQVSFWVVREILTAQTLKI--RAEILSHFVK 127
E WS++++ A P V A +FN V+ V+ +L A L RA+ L +++
Sbjct: 270 ECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGSVLGAPGLAAPQRAQRLEKWIR 329
Query: 128 IAKKLLELNNLHSLMSVVSALQSAPIFRLTKTWALLNRKDKTTFEKLDYLMSKEDNYKRT 187
IA++ EL N SL +++SALQS PI+RL ++W ++R+ +TF KL + S E+N+ +
Sbjct: 330 IAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREPLSTFRKLSQIFSDENNHLSS 389
Query: 188 REYI----------------RSLKMVP---SIPYLGIYLLDLIYIDSAYP--ASGSIMEN 226
RE + SL P +PYLG +L DL+ +D+A P G ++
Sbjct: 390 REILFQEEATEGSQEEDNTPGSLPSKPPPGPVPYLGTFLTDLVMLDTALPDMLEGDLINF 449
Query: 227 EQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQKFVEDDNYKLSLRI 286
E+R + IL I LQ C L+ P + + + + E+ +Y+LS I
Sbjct: 450 EKRRKEW-EILARIQQLQRRCQSYTLSPHPPI------LAALHAQNQLTEEQSYRLSRVI 502
Query: 287 EPGS----SSPRL---------VSSK---EDLAGPSAGSGSARFSRRPTCPDTSVAGSLP 330
EP + SSPR+ +S+K E + PS G P+ P +SV+ P
Sbjct: 503 EPPAASCPSSPRIRRRISLTKRLSAKLAREKSSSPSGSPGD------PSSPTSSVSPGSP 556
Query: 331 TPPVPRHR 338
P PR R
Sbjct: 557 -PSSPRSR 563
>gi|239582765 ral guanine nucleotide dissociation stimulator-like 3
isoform 1 [Homo sapiens]
Length = 716
Score = 125 bits (313), Expect = 1e-28
Identities = 106/368 (28%), Positives = 174/368 (47%), Gaps = 50/368 (13%)
Query: 13 VTSATPQGSSSSDSLEGQSCDYASKSYDAVVFDVLKVTPEEFASQITLMDIPVFKAIQPE 72
V + P+ + +SD ++C + +L + +E A Q+TL+D+ +F ++
Sbjct: 210 VWTGPPRVAQTSDPDSSEACAEEEEGLMPQGPQLLDFSVDEVAEQLTLIDLELFSKVRLY 269
Query: 73 ELASCGWSKKEKHSLA---PNVVAFTRRFNQVSFWVVREILTAQTLKI--RAEILSHFVK 127
E WS++++ A P V A +FN V+ V+ +L A L RA+ L +++
Sbjct: 270 ECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGSVLGAPGLAAPQRAQRLEKWIR 329
Query: 128 IAKKLLELNNLHSLMSVVSALQSAPIFRLTKTWALLNRKDKTTFEKLDYLMSKEDNYKRT 187
IA++ EL N SL +++SALQS PI+RL ++W ++R+ +TF KL + S E+N+ +
Sbjct: 330 IAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREPLSTFRKLSQIFSDENNHLSS 389
Query: 188 REYI----------------RSLKMVP---SIPYLGIYLLDLIYIDSAYP--ASGSIMEN 226
RE + SL P +PYLG +L DL+ +D+A P G ++
Sbjct: 390 REILFQEEATEGSQEEDNTPGSLPSKPPPGPVPYLGTFLTDLVMLDTALPDMLEGDLINF 449
Query: 227 EQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQKFVEDDNYKLSLRI 286
E+R + IL I LQ C L+ P + + + + E+ +Y+LS I
Sbjct: 450 EKRRKEW-EILARIQQLQRRCQSYTLSPHPPI------LAALHAQNQLTEEQSYRLSRVI 502
Query: 287 EPGS----SSPRL---------VSSK---EDLAGPSAGSGSARFSRRPTCPDTSVAGSLP 330
EP + SSPR+ +S+K E + PS G C SV+ P
Sbjct: 503 EPPAASCPSSPRIRRRISLTKRLSAKLAREKSSSPSGSPGDPSSPTSSLCISPSVSPGSP 562
Query: 331 TPPVPRHR 338
P PR R
Sbjct: 563 -PSSPRSR 569
>gi|38505170 Ras protein-specific guanine nucleotide-releasing factor
2 [Homo sapiens]
Length = 1237
Score = 123 bits (309), Expect = 4e-28
Identities = 78/238 (32%), Positives = 128/238 (53%), Gaps = 11/238 (4%)
Query: 53 EFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAFTRRFNQVSFWVVREILTA 112
E A QITL+D +F++I EE GW K +K+ P ++ ++ FN +S V +I+
Sbjct: 1005 ELAEQITLLDHVIFRSIPYEEFLGQGWMKLDKNERTPYIMKTSQHFNDMSNLVASQIMNY 1064
Query: 113 QTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFRLTKTWALLNRKDKTTFE 172
+ RA + +V +A L+N + ++ + SAL + I+RL KTWA ++++ K +
Sbjct: 1065 ADVSSRANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVSKQTKALMD 1124
Query: 173 KLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDSAYP-ASGSIMENEQRSN 231
KL +S E +K RE +++ P++PYLG+YL DL +I+ P + + N +
Sbjct: 1125 KLQKTVSSEGRFKNLRETLKNCN-PPAVPYLGMYLTDLAFIEEGTPNFTEEGLVNFSKMR 1183
Query: 232 QMNNILRIIADL-QVSCSYDHLTTLPHVQKYLKSVRYIEELQKFVEDDNYKLSLRIEP 288
+++I+R I Q S DH P V +YL I + ED Y+LSL+IEP
Sbjct: 1184 MISHIIREIRQFQQTSYRIDH---QPKVAQYLLDKDLIID-----EDTLYELSLKIEP 1233
>gi|224586880 Ras protein-specific guanine nucleotide-releasing factor
1 isoform 3 [Homo sapiens]
Length = 1257
Score = 123 bits (308), Expect = 5e-28
Identities = 76/239 (31%), Positives = 127/239 (53%), Gaps = 13/239 (5%)
Query: 53 EFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAFTRRFNQVSFWVVREILTA 112
E A Q+TL+D VFK I EE GW K EK+ P ++ T+ FN +S + EI+
Sbjct: 1025 EIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLIASEIIRN 1084
Query: 113 QTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFRLTKTWALLNRKDKTTFE 172
+ + R + +V +A L+N ++++ + S++ + IFRL KTW ++++ K +
Sbjct: 1085 EDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKALID 1144
Query: 173 KLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDSAYP-ASGSIMENEQRSN 231
KL L+S E +K RE +++ P +PYLG+YL DL +I+ P + + N +
Sbjct: 1145 KLQKLVSSEGRFKNLREALKNCD-PPCVPYLGMYLTDLAFIEEGTPNYTEDGLVNFSKMR 1203
Query: 232 QMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQKFVEDDN--YKLSLRIEP 288
+++I+R I Q T ++ K +Y+ + Q FV D+ Y+ SLRIEP
Sbjct: 1204 MISHIIREIRQFQ--------QTAYKIEHQAKVTQYLLD-QSFVMDEESLYESSLRIEP 1253
>gi|24797099 Ras protein-specific guanine nucleotide-releasing factor
1 isoform 1 [Homo sapiens]
Length = 1273
Score = 123 bits (308), Expect = 5e-28
Identities = 76/239 (31%), Positives = 127/239 (53%), Gaps = 13/239 (5%)
Query: 53 EFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAFTRRFNQVSFWVVREILTA 112
E A Q+TL+D VFK I EE GW K EK+ P ++ T+ FN +S + EI+
Sbjct: 1041 EIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLIASEIIRN 1100
Query: 113 QTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFRLTKTWALLNRKDKTTFE 172
+ + R + +V +A L+N ++++ + S++ + IFRL KTW ++++ K +
Sbjct: 1101 EDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKALID 1160
Query: 173 KLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDSAYP-ASGSIMENEQRSN 231
KL L+S E +K RE +++ P +PYLG+YL DL +I+ P + + N +
Sbjct: 1161 KLQKLVSSEGRFKNLREALKNCD-PPCVPYLGMYLTDLAFIEEGTPNYTEDGLVNFSKMR 1219
Query: 232 QMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQKFVEDDN--YKLSLRIEP 288
+++I+R I Q T ++ K +Y+ + Q FV D+ Y+ SLRIEP
Sbjct: 1220 MISHIIREIRQFQ--------QTAYKIEHQAKVTQYLLD-QSFVMDEESLYESSLRIEP 1269
>gi|24797101 Ras protein-specific guanine nucleotide-releasing
factor 1 isoform 2 [Homo sapiens]
Length = 489
Score = 123 bits (308), Expect = 5e-28
Identities = 76/239 (31%), Positives = 127/239 (53%), Gaps = 13/239 (5%)
Query: 53 EFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAFTRRFNQVSFWVVREILTA 112
E A Q+TL+D VFK I EE GW K EK+ P ++ T+ FN +S + EI+
Sbjct: 257 EIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLIASEIIRN 316
Query: 113 QTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFRLTKTWALLNRKDKTTFE 172
+ + R + +V +A L+N ++++ + S++ + IFRL KTW ++++ K +
Sbjct: 317 EDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKALID 376
Query: 173 KLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDSAYP-ASGSIMENEQRSN 231
KL L+S E +K RE +++ P +PYLG+YL DL +I+ P + + N +
Sbjct: 377 KLQKLVSSEGRFKNLREALKNCD-PPCVPYLGMYLTDLAFIEEGTPNYTEDGLVNFSKMR 435
Query: 232 QMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQKFVEDDN--YKLSLRIEP 288
+++I+R I Q T ++ K +Y+ + Q FV D+ Y+ SLRIEP
Sbjct: 436 MISHIIREIRQFQ--------QTAYKIEHQAKVTQYLLD-QSFVMDEESLYESSLRIEP 485
>gi|24307909 ral guanine nucleotide dissociation stimulator isoform
1 [Homo sapiens]
Length = 914
Score = 119 bits (298), Expect = 7e-27
Identities = 108/402 (26%), Positives = 178/402 (44%), Gaps = 60/402 (14%)
Query: 46 VLKVTPEEFASQITLMDIPVFKAIQPEELASCGWS---KKEKHSLAPNVVAFTRRFNQVS 102
+L P+ A Q TLMD +FK + P WS KK K LAP + A +FN V+
Sbjct: 382 LLVFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVTQFNSVA 441
Query: 103 FWVVREILTAQTLKI--RAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFRLTKTW 160
V+ L ++ K RA ++ H++++A++ L N SL +++SALQS I RL KTW
Sbjct: 442 NCVITTCLGNRSTKAPDRARVVEHWIEVARECRILKNFSSLYAILSALQSNSIHRLKKTW 501
Query: 161 ALLNRKDKTTFEKLDYLMSKEDNYKRTREYI--------RSLKMVP-------------- 198
++R F+KL + S E+NY +RE + +L+M P
Sbjct: 502 EDVSRDSFRIFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMNPKRAQKRPKETGIIQ 561
Query: 199 -SIPYLGIYLLDLIYIDSAYP--ASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTL 255
++PYLG +L DL+ +D+A G ++ E+R + I +I LQ +C+ +
Sbjct: 562 GTVPYLGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKL-LQSACNNYSIAPD 620
Query: 256 PHVQKYLKSVRYIEELQKFVEDDNYKLSLRIEPGSSS----------PRLVSSKEDLAGP 305
+ ++V ++ E ++Y LS +EP S S +V D P
Sbjct: 621 EQFGAWFRAV------ERLSETESYNLSCELEPPSESASNTLRTKKNTAIVKRWSDRQAP 674
Query: 306 SAGSGSARFSRRPTCPDTSVAGSLPTPPVPRHRKSHSLGNNMMCQLSVVESKSATFPSEK 365
S ++ S +C L + + HS G++ S VE + +F E
Sbjct: 675 STELSTSGSSHSKSCDQLRCGPYLSSGDIADALSVHSAGSSS----SDVEEINISFVPES 730
Query: 366 ARHLLDDSVLESRSPRRGLALTSSSAVTNGLSLGSSESSEFS 407
+ + + + + SS T+G+S SS +S S
Sbjct: 731 P---------DGQEKKFWESASQSSPETSGISSASSSTSSSS 763
>gi|108796058 ral guanine nucleotide dissociation stimulator isoform
2 [Homo sapiens]
Length = 859
Score = 119 bits (298), Expect = 7e-27
Identities = 108/402 (26%), Positives = 178/402 (44%), Gaps = 60/402 (14%)
Query: 46 VLKVTPEEFASQITLMDIPVFKAIQPEELASCGWS---KKEKHSLAPNVVAFTRRFNQVS 102
+L P+ A Q TLMD +FK + P WS KK K LAP + A +FN V+
Sbjct: 327 LLVFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVTQFNSVA 386
Query: 103 FWVVREILTAQTLKI--RAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFRLTKTW 160
V+ L ++ K RA ++ H++++A++ L N SL +++SALQS I RL KTW
Sbjct: 387 NCVITTCLGNRSTKAPDRARVVEHWIEVARECRILKNFSSLYAILSALQSNSIHRLKKTW 446
Query: 161 ALLNRKDKTTFEKLDYLMSKEDNYKRTREYI--------RSLKMVP-------------- 198
++R F+KL + S E+NY +RE + +L+M P
Sbjct: 447 EDVSRDSFRIFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMNPKRAQKRPKETGIIQ 506
Query: 199 -SIPYLGIYLLDLIYIDSAYP--ASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTL 255
++PYLG +L DL+ +D+A G ++ E+R + I +I LQ +C+ +
Sbjct: 507 GTVPYLGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKL-LQSACNNYSIAPD 565
Query: 256 PHVQKYLKSVRYIEELQKFVEDDNYKLSLRIEPGSSS----------PRLVSSKEDLAGP 305
+ ++V ++ E ++Y LS +EP S S +V D P
Sbjct: 566 EQFGAWFRAV------ERLSETESYNLSCELEPPSESASNTLRTKKNTAIVKRWSDRQAP 619
Query: 306 SAGSGSARFSRRPTCPDTSVAGSLPTPPVPRHRKSHSLGNNMMCQLSVVESKSATFPSEK 365
S ++ S +C L + + HS G++ S VE + +F E
Sbjct: 620 STELSTSGSSHSKSCDQLRCGPYLSSGDIADALSVHSAGSSS----SDVEEINISFVPES 675
Query: 366 ARHLLDDSVLESRSPRRGLALTSSSAVTNGLSLGSSESSEFS 407
+ + + + + SS T+G+S SS +S S
Sbjct: 676 P---------DGQEKKFWESASQSSPETSGISSASSSTSSSS 708
>gi|15529996 son of sevenless homolog 1 [Homo sapiens]
Length = 1333
Score = 113 bits (282), Expect = 5e-25
Identities = 71/261 (27%), Positives = 134/261 (51%), Gaps = 22/261 (8%)
Query: 44 FDVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAFTRRFNQVSF 103
FD+L + P E A Q+TL++ +++A+QP EL W+K++K +PN++ R ++
Sbjct: 774 FDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTL 833
Query: 104 WVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFRLTKTWALL 163
W + I+ + L+ R ++S ++I + ELNN + ++ VVSA+ S+P++RL T+ +
Sbjct: 834 WFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQI 893
Query: 164 NRKDKTTFEKLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDSAYPASGSI 223
+ K E+ L ED+YK+ +RS+ P +P+ GIYL +++ + P +
Sbjct: 894 PSRQKKILEEAHEL--SEDHYKKYLAKLRSIN-PPCVPFFGIYLTNILKTEEGNP---EV 947
Query: 224 MENEQRS----NQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEEL-------Q 272
++ + ++ + I ++Q Y + V+ +K R+ E L +
Sbjct: 948 LKRHGKELINFSKRRKVAEITGEIQ---QYQNQPYCLRVESDIK--RFFENLNPMGNSME 1002
Query: 273 KFVEDDNYKLSLRIEPGSSSP 293
K D + SL IEP + P
Sbjct: 1003 KEFTDYLFNKSLEIEPRNPKP 1023
>gi|93102367 ral guanine nucleotide dissociation stimulator-like 1
[Homo sapiens]
Length = 803
Score = 110 bits (276), Expect = 3e-24
Identities = 117/422 (27%), Positives = 185/422 (43%), Gaps = 69/422 (16%)
Query: 29 GQSCDYASKSYDAVVFDVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWS---KKEKH 85
G+S ++ S D V A Q+T MD +FK + P C WS KKE
Sbjct: 258 GESAEFTCFSEDLV------------AEQLTYMDAQLFKKVVPHHCLGCIWSRRDKKENK 305
Query: 86 SLAPNVVAFTRRFNQVSFWVVREILTAQTLKI--RAEILSHFVKIAKKLLELNNLHSLMS 143
LAP + A +FN ++ VV IL + LK RA+I+ ++ IA + L N SL +
Sbjct: 306 HLAPTIRATISQFNTLTKCVVSTILGGKELKTQQRAKIIEKWINIAHECRLLKNFSSLRA 365
Query: 144 VVSALQSAPIFRLTKTWALLNRKDKTTFEKL--------DYLMSKE-------------- 181
+VSALQS I+RL KTWA + R FE+L ++L S+E
Sbjct: 366 IVSALQSNSIYRLKKTWAAVPRDRMLMFEELSDIFSDHNNHLTSRELLMKEGTSKFANLD 425
Query: 182 ----DNYKRTREYIRSLK----MVPSIPYLGIYLLDLIYIDSAYP--ASGSIMENEQRSN 231
+N KRT+ ++ K M ++PYLG +L DL +D+A G ++ E+R
Sbjct: 426 SSVKENQKRTQRRLQLQKDMGVMQGTVPYLGTFLTDLTMLDTALQDYIEGGLINFEKRRR 485
Query: 232 QMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQKFVEDDNYKLSLRIEPGSS 291
+ I +I LQ +C+ +T QK+ +++ + Q E+++Y LS IE +
Sbjct: 486 EFEVIAQIKL-LQSACNSYCMTP---DQKF---IQWFQRQQLLTEEESYALSCEIEAAAD 538
Query: 292 SPRLVSSKEDLAGPSAGSGSARFSRRPTCPDTSVAGSLPTPPVPRHRKSHSLGNNMMCQL 351
+ P + + PT P+ S S G + M +
Sbjct: 539 A--------STTSPKPRKSMVKRLSLLFLGSDMITSPTPTKEQPKSTASGSSGES-MDSV 589
Query: 352 SVVESKSATFPSEKARHLLDDSVLESRSPRRGLALTSSSAVT-NGLSLGSSESSEFSEEM 410
SV +S +E+ D+ E P++ L+ +SSS + + + SS S +
Sbjct: 590 SVSSCESNHSEAEEGSITPMDTPDE---PQKKLSESSSSCSSIHSMDTNSSGMSSLINPL 646
Query: 411 SS 412
SS
Sbjct: 647 SS 648
>gi|4758532 ral guanine nucleotide dissociation stimulator-like 2
[Homo sapiens]
Length = 777
Score = 102 bits (254), Expect = 9e-22
Identities = 111/413 (26%), Positives = 177/413 (42%), Gaps = 71/413 (17%)
Query: 45 DVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEK--HS-LAPNVVAFTRRFNQV 101
DVL + A Q+TL+D +F + P + W +++ HS L P+V A +FN+V
Sbjct: 238 DVLVFLADHLAEQLTLLDAELFLNLIPSQCLGGLWGHRDRPGHSHLCPSVRATVTQFNKV 297
Query: 102 SFWVVREILTAQTL--------------KIRAEILSHFVKIAKKLLELNNLHSLMSVVSA 147
+ VV +L A + RA +L ++++A++ L N S+ +VVSA
Sbjct: 298 AGAVVSSVLGATSTGEGPGEVTIRPLRPPQRARLLEKWIRVAEECRLLRNFSSVYAVVSA 357
Query: 148 LQSAPIFRLTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTREYIRSLKMVPS-------- 199
LQS+PI RL W R F L + S+EDNY ++RE + + S
Sbjct: 358 LQSSPIHRLRAAWGEATRDSLRVFSSLCQIFSEEDNYSQSRELLVQEVKLQSPLEPHSKK 417
Query: 200 -----------IPYLGIYLLDLIYIDSAYPASGSIMEN-----EQRSNQMNNILRIIADL 243
+PYLG +L DL+ +D+ AS +EN ++R + +L + L
Sbjct: 418 APRSGSRGGGVVPYLGTFLKDLVMLDA---ASKDELENGYINFDKRRKEF-AVLSELRRL 473
Query: 244 QVSCSYDHLTTLPHVQKYLKSVRYIEELQKFVEDDNYKLSLRIEPGSSS---------PR 294
Q C +L +Q++L+ +R + E Q ++++S +EP SS P
Sbjct: 474 QNECRGYNLQPDHDIQRWLQGLRPLTEAQ------SHRVSCEVEPPGSSDPPAPRVLRPT 527
Query: 295 LVSSKEDLAGPSAGSGSARFSRRPTCPDTSVAG-SLPTPPVP--RHRKSHSLGNNMMCQL 351
LV S+ S G + S C S G PT P P H ++
Sbjct: 528 LVISQWTEVLGSVGVPTPLVS----CDRPSTGGDEAPTTPAPLLTRLAQHMKWPSVSSLD 583
Query: 352 SVVESKSATFPSEKARHLLDDSVLESRSPRRGLALTSSSAVTNGLSLGSSESS 404
S +ES + HL + SPR S++ + LS G+ E+S
Sbjct: 584 SALESSPSLHSPADPSHLSP----PASSPRPSRGHRRSASCGSPLSGGAEEAS 632
>gi|154689780 son of sevenless homolog 2 [Homo sapiens]
Length = 1332
Score = 101 bits (251), Expect = 2e-21
Identities = 79/336 (23%), Positives = 161/336 (47%), Gaps = 25/336 (7%)
Query: 34 YASKSYDAVVFDVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVA 93
+ SK FD++ + P E A Q+TL++ +++ +QP EL W+K++K +PN++
Sbjct: 762 HISKPGQFETFDLMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLK 821
Query: 94 FTRRFNQVSFWVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPI 153
R ++ W + I+ A+ + R +LS ++I + +LNN + ++ +VSA+ S +
Sbjct: 822 MIRHTTNLTLWFEKCIVEAENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSV 881
Query: 154 FRLTKTW-ALLNRKDKTTFEKLDYLMSKEDNYKRTREYIRSLKMV--PSIPYLGIYLLDL 210
+RL T+ AL RK K E ++ +D++K+ Y+ LK + P +P+ GIYL ++
Sbjct: 882 YRLDHTFEALQERKRKILDEAVEL---SQDHFKK---YLVKLKSINPPCVPFFGIYLTNI 935
Query: 211 IYIDSAYPASGSIMENEQRS----NQMNNILRIIADLQVSCSYDH-LTTLPHVQKYLKSV 265
+ + + ++ + + ++ + I ++Q + + L P ++++ +++
Sbjct: 936 LKTEE---GNNDFLKKKGKDLINFSKRRKVAEITGEIQQYQNQPYCLRIEPDMRRFFENL 992
Query: 266 RYI-EELQKFVEDDNYKLSLRIEP-GSSSPRLVSSKEDLAGPSAGSGSARFSRRPTCPDT 323
+ +K D + SL IEP P K + S G R T
Sbjct: 993 NPMGSASEKEFTDYLFNKSLEIEPRNCKQPPRFPRKSTFSLKSPG------IRPNTGRHG 1046
Query: 324 SVAGSLPTPPVPRHRKSHSLGNNMMCQLSVVESKSA 359
S +G+L P P R+ + + + + + + SA
Sbjct: 1047 STSGTLRGHPTPLEREPCKISFSRIAETELESTVSA 1082
>gi|23957680 ral guanine nucleotide dissociation stimulator-like 4
[Homo sapiens]
Length = 473
Score = 101 bits (251), Expect = 2e-21
Identities = 79/266 (29%), Positives = 131/266 (49%), Gaps = 31/266 (11%)
Query: 45 DVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSK---KEKHSLAPNVVAFTRRFNQV 101
D+ P A Q+TLMD +FK + E C W + K +AP V A FN++
Sbjct: 214 DMTTFPPRLLAEQLTLMDAELFKKVVLHECLGCIWGQGHLKGNEHMAPTVRATIAHFNRL 273
Query: 102 SFWVVREILTAQTLKIR--AEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFRLTKT 159
+ + L +++ R A ++ H++K+A++ L LNN S+ +VSAL S PI +L KT
Sbjct: 274 TNCITTSCLGDHSMRARDRARVVEHWIKVARECLSLNNFSSVHVIVSALCSNPIGQLHKT 333
Query: 160 WALLNRKD---------KTTFEKLDYLM--------SKEDNYKRTREYIRSLKMVPSIPY 202
WA ++ K K T K D L+ ++E N +R + +R K +P+
Sbjct: 334 WAGVSSKSMKELKELCKKDTAVKRDLLIKAGSFKVATQERNPQRVQMRLRRQKK-GVVPF 392
Query: 203 LGIYLLDLIYIDSAYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYL 262
LG +L +L +DSA P + N + ++ +L+ + LQV+ L L
Sbjct: 393 LGDFLTELQRLDSAIP--DDLDGNTNKRSKEVRVLQEMQLLQVAAMNYRLRPLE------ 444
Query: 263 KSVRYIEELQKFVEDDNYKLSLRIEP 288
K V Y +++ + ++YKLS ++EP
Sbjct: 445 KFVTYFTRMEQLSDKESYKLSCQLEP 470
>gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Homo
sapiens]
Length = 1095
Score = 98.2 bits (243), Expect = 2e-20
Identities = 79/252 (31%), Positives = 123/252 (48%), Gaps = 23/252 (9%)
Query: 53 EFASQITLMDIPVFKAIQ-PEELASCGWSKKEKHSLAPNVVAFTRRFNQVSFWVVREILT 111
E A Q+TL+D +F I+ PE L W+K++ +PN+ FT FN +S+WV I+
Sbjct: 861 EIAEQLTLLDAELFYKIEIPEVLL---WAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIML 917
Query: 112 AQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFRLTKTWALLNRKDKTTF 171
+ + R +L F+KI K L +LNN +S ++++SAL SAPI RL W K T
Sbjct: 918 QEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRL--EW------QKQTS 969
Query: 172 EKLDYLMSKEDNYKRTREYIRSLKMV--PSIPYLGIYLLDLIYIDSAYPASGSIMENEQR 229
E L + D+ R Y +L V P IPYLG+ L DL ++ P N +
Sbjct: 970 EGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSK 1029
Query: 230 SNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEEL-QKFVEDDNYKLSLRIEP 288
Q NIL + Q YD +++ + + + E+ ++LSL+I+P
Sbjct: 1030 RWQQFNILDSMRCFQ-QAHYD-------MRRNDDIINFFNDFSDHLAEEALWELSLKIKP 1081
Query: 289 GSSSPRLVSSKE 300
+ + R +E
Sbjct: 1082 RNITRRKTDREE 1093
>gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Homo
sapiens]
Length = 1077
Score = 98.2 bits (243), Expect = 2e-20
Identities = 79/252 (31%), Positives = 123/252 (48%), Gaps = 23/252 (9%)
Query: 53 EFASQITLMDIPVFKAIQ-PEELASCGWSKKEKHSLAPNVVAFTRRFNQVSFWVVREILT 111
E A Q+TL+D +F I+ PE L W+K++ +PN+ FT FN +S+WV I+
Sbjct: 843 EIAEQLTLLDAELFYKIEIPEVLL---WAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIML 899
Query: 112 AQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFRLTKTWALLNRKDKTTF 171
+ + R +L F+KI K L +LNN +S ++++SAL SAPI RL W K T
Sbjct: 900 QEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRL--EW------QKQTS 951
Query: 172 EKLDYLMSKEDNYKRTREYIRSLKMV--PSIPYLGIYLLDLIYIDSAYPASGSIMENEQR 229
E L + D+ R Y +L V P IPYLG+ L DL ++ P N +
Sbjct: 952 EGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSK 1011
Query: 230 SNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEEL-QKFVEDDNYKLSLRIEP 288
Q NIL + Q YD +++ + + + E+ ++LSL+I+P
Sbjct: 1012 RWQQFNILDSMRCFQ-QAHYD-------MRRNDDIINFFNDFSDHLAEEALWELSLKIKP 1063
Query: 289 GSSSPRLVSSKE 300
+ + R +E
Sbjct: 1064 RNITRRKTDREE 1075
>gi|155030206 Rap guanine nucleotide exchange factor (GEF) 4 isoform
b [Homo sapiens]
Length = 867
Score = 87.4 bits (215), Expect = 3e-17
Identities = 51/192 (26%), Positives = 90/192 (46%), Gaps = 1/192 (0%)
Query: 49 VTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAFTRRFNQVSFWVVRE 108
++ ++ A Q+T+ D +F + EL + + N+ F RRFN++ FWVV E
Sbjct: 627 MSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTE 686
Query: 109 ILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFRLTKTWALLNRKDK 168
I L R ++L F+KIA E NL+S ++V L + + RL TW L K K
Sbjct: 687 ICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFK 746
Query: 169 TTFEKLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDSAYPASGSIMENEQ 228
+ + + LM N++ R + L+ P IP++ + + D+ + + N +
Sbjct: 747 KFYAEFESLMDPSRNHRAYRLTVAKLE-PPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFE 805
Query: 229 RSNQMNNILRII 240
+ + N R +
Sbjct: 806 KMRMIANTARTV 817
>gi|155030204 Rap guanine nucleotide exchange factor (GEF) 4 isoform
a [Homo sapiens]
Length = 1011
Score = 87.4 bits (215), Expect = 3e-17
Identities = 51/192 (26%), Positives = 90/192 (46%), Gaps = 1/192 (0%)
Query: 49 VTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAFTRRFNQVSFWVVRE 108
++ ++ A Q+T+ D +F + EL + + N+ F RRFN++ FWVV E
Sbjct: 771 MSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTE 830
Query: 109 ILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFRLTKTWALLNRKDK 168
I L R ++L F+KIA E NL+S ++V L + + RL TW L K K
Sbjct: 831 ICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFK 890
Query: 169 TTFEKLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDSAYPASGSIMENEQ 228
+ + + LM N++ R + L+ P IP++ + + D+ + + N +
Sbjct: 891 KFYAEFESLMDPSRNHRAYRLTVAKLE-PPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFE 949
Query: 229 RSNQMNNILRII 240
+ + N R +
Sbjct: 950 KMRMIANTARTV 961
>gi|119392077 Rap guanine nucleotide exchange factor (GEF) 5 [Homo
sapiens]
Length = 730
Score = 87.4 bits (215), Expect = 3e-17
Identities = 61/245 (24%), Positives = 117/245 (47%), Gaps = 9/245 (3%)
Query: 46 VLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAFTRRFNQVSFWV 105
+L + + A ++ D +F +I +EL +S++ N+ +R N+V WV
Sbjct: 491 ILGMNTWDLALELMNFDWSLFNSIHEQELIYFTFSRQGSGEHTANLSLLLQRCNEVQLWV 550
Query: 106 VREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFRLTKTWALLNR 165
EIL L R +++ F+KIA NL+S ++V L +A + RL++TW +
Sbjct: 551 ATEILLCSQLGKRVQLVKKFIKIAAHCKAQRNLNSFFAIVMGLNTASVSRLSQTWEKIPG 610
Query: 166 KDKTTFEKLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDSAYPASGSIME 225
K K F +L+ L N+K R+ + +K P IP++ + L D+ +I +
Sbjct: 611 KFKKLFSELESLTDPSLNHKAYRDAFKKMK-PPKIPFMPLLLKDVTFIHEGNKTFLDNLV 669
Query: 226 NEQRSNQMNNILRIIADLQVSCSYDHLTTLPH--VQKYLKSVRYIEELQKFVEDDNYKLS 283
N ++ + + + +R + + + + L+ H ++ Y+ + I+ Q ++LS
Sbjct: 670 NFEKLHMIADTVRTLRHCRTN-QFGDLSPKEHQELKSYVNHLYVIDSQQAL-----FELS 723
Query: 284 LRIEP 288
RIEP
Sbjct: 724 HRIEP 728
>gi|213385270 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 1 [Homo sapiens]
Length = 690
Score = 87.0 bits (214), Expect = 4e-17
Identities = 75/269 (27%), Positives = 129/269 (47%), Gaps = 22/269 (8%)
Query: 35 ASKSYDAVVFDVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAF 94
+ K ++FD L+ P E A +T ++ F+ I + S +++ P +
Sbjct: 139 SKKGKACLLFDHLE--PIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENN--PTLERS 194
Query: 95 TRRFNQVSFWVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIF 154
FN +S WV +L+ T + RAE+++ F+ +AKKLL+L N ++LM+VV L + I
Sbjct: 195 IALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSIS 254
Query: 155 RLTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYID 214
RL +T + L+ + + ++ L+S NY R+ IP LG++L DLI +
Sbjct: 255 RLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGF-KIPILGVHLKDLIAVH 313
Query: 215 SAYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQKF 274
+P + N++N I+ Q+S + L +L + +L+ + L
Sbjct: 314 VIFP-------DWTEENKVN----IVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTL 362
Query: 275 ------VEDDNYKLSLRIEPGSSSPRLVS 297
EDD YKLSL +EP +S + S
Sbjct: 363 SLDLYHTEDDIYKLSLVLEPRNSKSQPTS 391
>gi|24762239 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 1 [Homo sapiens]
Length = 690
Score = 87.0 bits (214), Expect = 4e-17
Identities = 75/269 (27%), Positives = 129/269 (47%), Gaps = 22/269 (8%)
Query: 35 ASKSYDAVVFDVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAF 94
+ K ++FD L+ P E A +T ++ F+ I + S +++ P +
Sbjct: 139 SKKGKACLLFDHLE--PIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENN--PTLERS 194
Query: 95 TRRFNQVSFWVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIF 154
FN +S WV +L+ T + RAE+++ F+ +AKKLL+L N ++LM+VV L + I
Sbjct: 195 IALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSIS 254
Query: 155 RLTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYID 214
RL +T + L+ + + ++ L+S NY R+ IP LG++L DLI +
Sbjct: 255 RLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGF-KIPILGVHLKDLIAVH 313
Query: 215 SAYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQKF 274
+P + N++N I+ Q+S + L +L + +L+ + L
Sbjct: 314 VIFP-------DWTEENKVN----IVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTL 362
Query: 275 ------VEDDNYKLSLRIEPGSSSPRLVS 297
EDD YKLSL +EP +S + S
Sbjct: 363 SLDLYHTEDDIYKLSLVLEPRNSKSQPTS 391
>gi|7662334 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 2 [Homo sapiens]
Length = 689
Score = 86.7 bits (213), Expect = 5e-17
Identities = 74/263 (28%), Positives = 127/263 (48%), Gaps = 22/263 (8%)
Query: 35 ASKSYDAVVFDVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAF 94
+ K ++FD L+ P E A +T ++ F+ I + S +++ P +
Sbjct: 139 SKKGKACLLFDHLE--PIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENN--PTLERS 194
Query: 95 TRRFNQVSFWVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIF 154
FN +S WV +L+ T + RAE+++ F+ +AKKLL+L N ++LM+VV L + I
Sbjct: 195 IALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSIS 254
Query: 155 RLTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYID 214
RL +T + L+ + + ++ L+S NY R+ IP LG++L DLI +
Sbjct: 255 RLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGF-KIPILGVHLKDLIAVH 313
Query: 215 SAYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQKF 274
+P + N++N I+ Q+S + L +L + +L+ + L
Sbjct: 314 VIFP-------DWTEENKVN----IVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTL 362
Query: 275 ------VEDDNYKLSLRIEPGSS 291
EDD YKLSL +EP +S
Sbjct: 363 SLDLYHTEDDIYKLSLVLEPRNS 385
>gi|7657261 Rap guanine nucleotide exchange factor 2 [Homo sapiens]
Length = 1499
Score = 85.9 bits (211), Expect = 9e-17
Identities = 52/169 (30%), Positives = 85/169 (50%), Gaps = 2/169 (1%)
Query: 46 VLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAFTRRFNQVSFWV 105
+L+++ E A+Q+++ + +F+ I+P E + + K S A N+ F NQ +FWV
Sbjct: 713 LLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLRSKTSCA-NLKRFEEVINQETFWV 771
Query: 106 VREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFRLTKTWALLNR 165
EIL R +I+ HF+KIA E N +S+ +++S L AP+ RL TW L
Sbjct: 772 ASEILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPN 831
Query: 166 KDKTTFEKLDYLMSKEDNYKRTREYIRSLKMVPS-IPYLGIYLLDLIYI 213
K + F+ L L N + R + S + P IP + DL ++
Sbjct: 832 KYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFL 880
>gi|7705939 Rap guanine nucleotide exchange factor (GEF)-like 1
[Homo sapiens]
Length = 456
Score = 83.6 bits (205), Expect = 4e-16
Identities = 59/248 (23%), Positives = 119/248 (47%), Gaps = 7/248 (2%)
Query: 45 DVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAFTRRFNQVSFW 104
++ +V PE+ A+ +T +F+ + E + + N+ +R ++V+ W
Sbjct: 213 EIHRVEPEDVANHLTAFHWELFRCVHELEFVDYVFHGERGRRETANLELLLQRCSEVTHW 272
Query: 105 VVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFRLTKTWALLN 164
V E+L + RA++L F+KIA + +L S +VV L +A + RL TW L
Sbjct: 273 VATEVLLCEAPGKRAQLLKKFIKIAALCKQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLP 332
Query: 165 RKDKTTFEKLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDSAYPASGSIM 224
K K F K + L N+K RE I +K P IP++ + L DL ++ + S +++
Sbjct: 333 GKFKNLFRKFENLTDPCRNHKSYREVISKMK-PPVIPFVPLILKDLTFL---HEGSKTLV 388
Query: 225 ENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQKFVEDDN--YKL 282
+ +++++ + ++ S + +L++ Y+ + Q +++ N ++L
Sbjct: 389 DGLVNIEKLHSVAEKVRTIRKYRSRPLCLDMEASPNHLQTKAYVRQFQ-VIDNQNLLFEL 447
Query: 283 SLRIEPGS 290
S ++E S
Sbjct: 448 SYKLEANS 455
>gi|24797103 RAS guanyl releasing protein 2 [Homo sapiens]
Length = 609
Score = 82.4 bits (202), Expect = 1e-15
Identities = 74/260 (28%), Positives = 120/260 (46%), Gaps = 24/260 (9%)
Query: 41 AVVFDVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLA--------PNVV 92
+++FD L+ P E A +T ++ F C ++ HS P +
Sbjct: 147 SLLFDHLE--PMELAEHLTYLEYRSF----------CKILFQDYHSFVTHGCTVDNPVLE 194
Query: 93 AFTRRFNQVSFWVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAP 152
F FN VS WV IL+ T RA +++HFV +A+KLL+L N ++LM+VV L +
Sbjct: 195 RFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVVGGLSHSS 254
Query: 153 IFRLTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIY 212
I RL +T + ++ + +E L L++ NY R + + + P LG++L DL+
Sbjct: 255 ISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAAC-VGFRFPILGVHLKDLVA 313
Query: 213 IDSAYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQ 272
+ A P +M + I+ +L + S L L S+ + Q
Sbjct: 314 LQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTS---LRPPVQANPDLLSLLTVSLDQ 370
Query: 273 KFVEDDNYKLSLRIEPGSSS 292
ED+ Y+LSL+ EP S S
Sbjct: 371 YQTEDELYQLSLQREPRSKS 390
>gi|149158729 RAS guanyl releasing protein 2 [Homo sapiens]
Length = 609
Score = 82.4 bits (202), Expect = 1e-15
Identities = 74/260 (28%), Positives = 120/260 (46%), Gaps = 24/260 (9%)
Query: 41 AVVFDVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLA--------PNVV 92
+++FD L+ P E A +T ++ F C ++ HS P +
Sbjct: 147 SLLFDHLE--PMELAEHLTYLEYRSF----------CKILFQDYHSFVTHGCTVDNPVLE 194
Query: 93 AFTRRFNQVSFWVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAP 152
F FN VS WV IL+ T RA +++HFV +A+KLL+L N ++LM+VV L +
Sbjct: 195 RFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVVGGLSHSS 254
Query: 153 IFRLTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIY 212
I RL +T + ++ + +E L L++ NY R + + + P LG++L DL+
Sbjct: 255 ISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAAC-VGFRFPILGVHLKDLVA 313
Query: 213 IDSAYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQ 272
+ A P +M + I+ +L + S L L S+ + Q
Sbjct: 314 LQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTS---LRPPVQANPDLLSLLTVSLDQ 370
Query: 273 KFVEDDNYKLSLRIEPGSSS 292
ED+ Y+LSL+ EP S S
Sbjct: 371 YQTEDELYQLSLQREPRSKS 390
>gi|149158727 RAS guanyl releasing protein 2 [Homo sapiens]
Length = 609
Score = 82.4 bits (202), Expect = 1e-15
Identities = 74/260 (28%), Positives = 120/260 (46%), Gaps = 24/260 (9%)
Query: 41 AVVFDVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLA--------PNVV 92
+++FD L+ P E A +T ++ F C ++ HS P +
Sbjct: 147 SLLFDHLE--PMELAEHLTYLEYRSF----------CKILFQDYHSFVTHGCTVDNPVLE 194
Query: 93 AFTRRFNQVSFWVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAP 152
F FN VS WV IL+ T RA +++HFV +A+KLL+L N ++LM+VV L +
Sbjct: 195 RFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVVGGLSHSS 254
Query: 153 IFRLTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIY 212
I RL +T + ++ + +E L L++ NY R + + + P LG++L DL+
Sbjct: 255 ISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAAC-VGFRFPILGVHLKDLVA 313
Query: 213 IDSAYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQ 272
+ A P +M + I+ +L + S L L S+ + Q
Sbjct: 314 LQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTS---LRPPVQANPDLLSLLTVSLDQ 370
Query: 273 KFVEDDNYKLSLRIEPGSSS 292
ED+ Y+LSL+ EP S S
Sbjct: 371 YQTEDELYQLSLQREPRSKS 390
>gi|148747862 Rap guanine nucleotide exchange factor 3 isoform b
[Homo sapiens]
Length = 881
Score = 78.2 bits (191), Expect = 2e-14
Identities = 53/191 (27%), Positives = 94/191 (49%), Gaps = 5/191 (2%)
Query: 49 VTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAP-NVVAFTRRFNQVSFWVVR 107
V+ ++ A Q+T D +F +I EL + + N+ F RRFN++ +WV
Sbjct: 619 VSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVAT 678
Query: 108 EILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFRLTKTWALLNRKD 167
E+ RA++L F+K+A L E NL+S +V+ L ++ I RL TW L K
Sbjct: 679 ELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKV 738
Query: 168 KTTFEKLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDSAYPASGSIMENE 227
+ + L+ L+ N++ R + L P IP++ + L D+ +I + + +++EN
Sbjct: 739 RKLYSALERLLDPSWNHRVYRLALAKLS-PPVIPFMPLLLKDMTFI---HEGNHTLVENL 794
Query: 228 QRSNQMNNILR 238
+M + R
Sbjct: 795 INFEKMRMMAR 805
>gi|20070215 Rap guanine nucleotide exchange factor 3 isoform b
[Homo sapiens]
Length = 881
Score = 78.2 bits (191), Expect = 2e-14
Identities = 53/191 (27%), Positives = 94/191 (49%), Gaps = 5/191 (2%)
Query: 49 VTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAP-NVVAFTRRFNQVSFWVVR 107
V+ ++ A Q+T D +F +I EL + + N+ F RRFN++ +WV
Sbjct: 619 VSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVAT 678
Query: 108 EILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFRLTKTWALLNRKD 167
E+ RA++L F+K+A L E NL+S +V+ L ++ I RL TW L K
Sbjct: 679 ELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKV 738
Query: 168 KTTFEKLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDSAYPASGSIMENE 227
+ + L+ L+ N++ R + L P IP++ + L D+ +I + + +++EN
Sbjct: 739 RKLYSALERLLDPSWNHRVYRLALAKLS-PPVIPFMPLLLKDMTFI---HEGNHTLVENL 794
Query: 228 QRSNQMNNILR 238
+M + R
Sbjct: 795 INFEKMRMMAR 805
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.130 0.377
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,178,225
Number of Sequences: 37866
Number of extensions: 970041
Number of successful extensions: 3753
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 64
Number of HSP's successfully gapped in prelim test: 71
Number of HSP's that attempted gapping in prelim test: 3570
Number of HSP's gapped (non-prelim): 186
length of query: 557
length of database: 18,247,518
effective HSP length: 107
effective length of query: 450
effective length of database: 14,195,856
effective search space: 6388135200
effective search space used: 6388135200
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.