Search of human proteins with 7661844

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|7661844 coiled-coil domain containing 22 [Homo sapiens]
         (627 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|7661844 coiled-coil domain containing 22 [Homo sapiens]           1222   0.0  
gi|115648142 centrosomal protein 164kDa [Homo sapiens]                 59   1e-08
gi|157671919 hypothetical protein LOC374864 isoform 1 [Homo sapi...    57   7e-08
gi|157671917 hypothetical protein LOC374864 isoform 2 [Homo sapi...    57   7e-08
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]     56   1e-07
gi|38044112 restin isoform b [Homo sapiens]                            56   1e-07
gi|4506751 restin isoform a [Homo sapiens]                             56   1e-07
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]    55   1e-07
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]         55   1e-07
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]                   55   1e-07
gi|45446749 kinesin family member 5A [Homo sapiens]                    55   3e-07
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                        54   3e-07
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                        54   3e-07
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                         54   3e-07
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                         54   3e-07
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                         54   3e-07
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                         54   3e-07
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                         54   3e-07
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                         54   3e-07
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H...    54   4e-07
gi|42794779 myosin 18A isoform b [Homo sapiens]                        54   4e-07
gi|28416946 myosin 18A isoform a [Homo sapiens]                        54   4e-07
gi|56550043 sarcolemma associated protein [Homo sapiens]               54   4e-07
gi|73623035 sperm associated antigen 5 [Homo sapiens]                  53   7e-07
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s...    52   2e-06
gi|55770834 centromere protein F [Homo sapiens]                        51   4e-06
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ...    51   4e-06
gi|46592991 GRIP1 associated protein 1 isoform 1 [Homo sapiens]        51   4e-06
gi|110611218 ribosome binding protein 1 [Homo sapiens]                 50   5e-06
gi|110611220 ribosome binding protein 1 [Homo sapiens]                 50   5e-06

>gi|7661844 coiled-coil domain containing 22 [Homo sapiens]
          Length = 627

 Score = 1222 bits (3162), Expect = 0.0
 Identities = 627/627 (100%), Positives = 627/627 (100%)

Query: 1   MEEADRILIHSLRQAGTAVPPDVQTLRAFTTELVVEAVVRCLRVINPAVGSGLSPLLPLA 60
           MEEADRILIHSLRQAGTAVPPDVQTLRAFTTELVVEAVVRCLRVINPAVGSGLSPLLPLA
Sbjct: 1   MEEADRILIHSLRQAGTAVPPDVQTLRAFTTELVVEAVVRCLRVINPAVGSGLSPLLPLA 60

Query: 61  MSARFRLAMSLAQACMDLGYPLELGYQNFLYPSEPDLRDLLLFLAERLPTDASEDADQPA 120
           MSARFRLAMSLAQACMDLGYPLELGYQNFLYPSEPDLRDLLLFLAERLPTDASEDADQPA
Sbjct: 61  MSARFRLAMSLAQACMDLGYPLELGYQNFLYPSEPDLRDLLLFLAERLPTDASEDADQPA 120

Query: 121 GDSAILLRAIGSQIRDQLALPWVPPHLRTPKLQHLQGSALQKPFHASRLVVPELSSRGEP 180
           GDSAILLRAIGSQIRDQLALPWVPPHLRTPKLQHLQGSALQKPFHASRLVVPELSSRGEP
Sbjct: 121 GDSAILLRAIGSQIRDQLALPWVPPHLRTPKLQHLQGSALQKPFHASRLVVPELSSRGEP 180

Query: 181 REFQASPLLLPVPTQVPQPVGRVASLLEHHALQLCQQTGRDRPGDEDWVHRTSRLPPQED 240
           REFQASPLLLPVPTQVPQPVGRVASLLEHHALQLCQQTGRDRPGDEDWVHRTSRLPPQED
Sbjct: 181 REFQASPLLLPVPTQVPQPVGRVASLLEHHALQLCQQTGRDRPGDEDWVHRTSRLPPQED 240

Query: 241 TRAQRQRLQKQLTEHLRQSWGLLGAPIQARDLGELLQAWGAGAKTGAPKGSRFTHSEKFT 300
           TRAQRQRLQKQLTEHLRQSWGLLGAPIQARDLGELLQAWGAGAKTGAPKGSRFTHSEKFT
Sbjct: 241 TRAQRQRLQKQLTEHLRQSWGLLGAPIQARDLGELLQAWGAGAKTGAPKGSRFTHSEKFT 300

Query: 301 FHLEPQAQATQVSDVPATSRRPEQVTWAAQEQELESLREQLEGVNRSIEEVEADMKTLGV 360
           FHLEPQAQATQVSDVPATSRRPEQVTWAAQEQELESLREQLEGVNRSIEEVEADMKTLGV
Sbjct: 301 FHLEPQAQATQVSDVPATSRRPEQVTWAAQEQELESLREQLEGVNRSIEEVEADMKTLGV 360

Query: 361 SFVQAESECRHSKLSTAEREQALRLKSRAVELLPDGTANLAKLQLVVENSAQRVIHLAGQ 420
           SFVQAESECRHSKLSTAEREQALRLKSRAVELLPDGTANLAKLQLVVENSAQRVIHLAGQ
Sbjct: 361 SFVQAESECRHSKLSTAEREQALRLKSRAVELLPDGTANLAKLQLVVENSAQRVIHLAGQ 420

Query: 421 WEKHRVPLLAEYRHLRKLQDCRELESSRRLAEIQELHQSVRAAAEEARRKEEVYKQLMSE 480
           WEKHRVPLLAEYRHLRKLQDCRELESSRRLAEIQELHQSVRAAAEEARRKEEVYKQLMSE
Sbjct: 421 WEKHRVPLLAEYRHLRKLQDCRELESSRRLAEIQELHQSVRAAAEEARRKEEVYKQLMSE 480

Query: 481 LETLPRDVSRLAYTQRILEIVGNIRKQKEEITKILSDTKELQKEINSLSGKLDRTFAVTD 540
           LETLPRDVSRLAYTQRILEIVGNIRKQKEEITKILSDTKELQKEINSLSGKLDRTFAVTD
Sbjct: 481 LETLPRDVSRLAYTQRILEIVGNIRKQKEEITKILSDTKELQKEINSLSGKLDRTFAVTD 540

Query: 541 ELVFKDAKKDDAVRKAYKYLAALHENCSQLIQTIEDTGTIMREVRDLEEQIETELGKKTL 600
           ELVFKDAKKDDAVRKAYKYLAALHENCSQLIQTIEDTGTIMREVRDLEEQIETELGKKTL
Sbjct: 541 ELVFKDAKKDDAVRKAYKYLAALHENCSQLIQTIEDTGTIMREVRDLEEQIETELGKKTL 600

Query: 601 SNLEKIREDYRALRQENAGLLGRVREA 627
           SNLEKIREDYRALRQENAGLLGRVREA
Sbjct: 601 SNLEKIREDYRALRQENAGLLGRVREA 627


>gi|115648142 centrosomal protein 164kDa [Homo sapiens]
          Length = 1460

 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 81/338 (23%), Positives = 145/338 (42%), Gaps = 46/338 (13%)

Query: 314  DVPATSRRPEQVTWAAQEQELESLREQLEGVNR-SIEEVEADMKTLGVSFVQAESECRHS 372
            ++ A+ +  +    AA+E+ L+ LREQLEG  + ++  +E +          AE E   S
Sbjct: 728  EIEASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEKEH--------SAELERLCS 779

Query: 373  KLSTAEREQALRLKSRAVELLPDGTANLAKLQLVVENSA-QRVIHLAGQWEKHRVPLLAE 431
             L    RE    L+ +  E      A L K    VE+   Q+  H+AG   +H +  L  
Sbjct: 780  SLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGY--EHELSSL-- 835

Query: 432  YRHLRKLQDCRELESSRRLAEIQELHQSVRA------AAEEARRKEEVYKQLMSELETLP 485
               LR+ +   E E  RRL +++E HQ V A       AEE +++ E+   L  ELE L 
Sbjct: 836  ---LREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGELERLQ 892

Query: 486  R------DVSRLAYTQRILEIVGNIRKQKEEITKILSDTKELQKEINSLSGKLDRTFAVT 539
            R      +  R    +R+ ++    R+Q+ ++  +  D +   K++ +    L+    V 
Sbjct: 893  RAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALLE----VQ 948

Query: 540  DELVFKD-----------AKKDDAVRKAYKYLAALHENCSQLIQTIEDTGTIMREV--RD 586
            +E   ++           A K +     ++ L    +  + L+Q+ +    I+ E+  R 
Sbjct: 949  EETARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARK 1008

Query: 587  LEEQIETELGKKTLSNLEKIREDYRALRQENAGLLGRV 624
            L+ + + +L +     L+K      A  Q+   LL  V
Sbjct: 1009 LKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREV 1046



 Score = 35.4 bits (80), Expect = 0.16
 Identities = 70/302 (23%), Positives = 133/302 (44%), Gaps = 64/302 (21%)

Query: 330 QEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHSKLSTAEREQALRLKSRA 389
           +EQ L SLRE+L+   ++IEE EA M+       + ES+    +LS    +     ++  
Sbjct: 640 KEQSLSSLRERLQ---KAIEEEEARMR-------EEESQ----RLSWLRAQVQSSTQADE 685

Query: 390 VELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQDCRELESSRR 449
            ++  +  A+L KL+  +E+          Q +  R  L  E ++ + L+  +E      
Sbjct: 686 DQIRAEQEASLQKLREELES----------QQKAERASL--EQKNRQMLEQLKE------ 727

Query: 450 LAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRLAYTQRILEIVGNIRKQKE 509
             EI+   +S +AA   A  KE+  +QL  +LE   +            E V  + K+  
Sbjct: 728 --EIEASEKSEQAALNAA--KEKALQQLREQLEGERK------------EAVATLEKE-- 769

Query: 510 EITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDA-VRKAYKYLA-ALHENC 567
                   + EL++  +SL  K     +   + + +  +K++A ++K    +   +H+  
Sbjct: 770 -------HSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKS 822

Query: 568 SQLIQTIEDTGTIMREVR-DLEEQIETELGKKTLSN---LEKIREDYRA-LRQENAGLLG 622
             +     +  +++RE R ++E + E  L K    +   + K RE Y A  R++ A LLG
Sbjct: 823 YHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLG 882

Query: 623 RV 624
            +
Sbjct: 883 HL 884


>gi|157671919 hypothetical protein LOC374864 isoform 1 [Homo
           sapiens]
          Length = 867

 Score = 56.6 bits (135), Expect = 7e-08
 Identities = 74/346 (21%), Positives = 154/346 (44%), Gaps = 48/346 (13%)

Query: 304 EPQAQATQVSDVPATSRRPEQVTWAAQEQELESLREQLEGVNRSIEEVEADMKTLGVSFV 363
           E  +  T V +V    +R E+      +QE+E+L  +   + +S+E   AD +   +   
Sbjct: 135 EDWSVTTPVKEVKPGEKRDEKCP--ELKQEMETLLSEAIRLIKSLETDRADAEE-ALKQQ 191

Query: 364 QAESECRHSKLSTAE----REQALRLKSRAVELLPDGTANLAKLQLVVENSAQRVIHLAG 419
           ++     + K+ +      +E  L ++      L D    + +LQ  +E+ A ++ H   
Sbjct: 192 RSRKNMINMKIDSWSVWKLQELPLAVQKEHEAYLSD----VIELQWHLEDKANQLQHFEK 247

Query: 420 Q---WEKHRVPLLAEYRHL---------RKLQDCRELESS-RRLAEIQELHQSVRAAAEE 466
           Q    E+    + A+  ++         ++ Q+ ++L++  ++  E+ +LH+ V    EE
Sbjct: 248 QKTELEEANAKIQADIDYMNEHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELEE 307

Query: 467 ARR------------KEEVYKQLMSE---LETLPRDVSRLA-----YTQRILEIVGNIRK 506
           A              KEE+ K +  +   +E   R++ +L      Y+  ++ +  NI +
Sbjct: 308 ALEACENARLKAQQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEE 367

Query: 507 QKEEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYK-YLAALHE 565
           ++EE+T+ + +TK  + E++SLS  L+    V D+L +K    ++   +A   + AA   
Sbjct: 368 KEEEVTEAIRETKSSKNELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKT 427

Query: 566 NCSQLIQTIEDTGTIMREVRDLEE---QIETELGKKTLSNLEKIRE 608
              +L    +D   I      L E   ++E ++ K T+   E IR+
Sbjct: 428 WDIELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRK 473


>gi|157671917 hypothetical protein LOC374864 isoform 2 [Homo
           sapiens]
          Length = 829

 Score = 56.6 bits (135), Expect = 7e-08
 Identities = 74/346 (21%), Positives = 154/346 (44%), Gaps = 48/346 (13%)

Query: 304 EPQAQATQVSDVPATSRRPEQVTWAAQEQELESLREQLEGVNRSIEEVEADMKTLGVSFV 363
           E  +  T V +V    +R E+      +QE+E+L  +   + +S+E   AD +   +   
Sbjct: 135 EDWSVTTPVKEVKPGEKRDEKCP--ELKQEMETLLSEAIRLIKSLETDRADAEE-ALKQQ 191

Query: 364 QAESECRHSKLSTAE----REQALRLKSRAVELLPDGTANLAKLQLVVENSAQRVIHLAG 419
           ++     + K+ +      +E  L ++      L D    + +LQ  +E+ A ++ H   
Sbjct: 192 RSRKNMINMKIDSWSVWKLQELPLAVQKEHEAYLSD----VIELQWHLEDKANQLQHFEK 247

Query: 420 Q---WEKHRVPLLAEYRHL---------RKLQDCRELESS-RRLAEIQELHQSVRAAAEE 466
           Q    E+    + A+  ++         ++ Q+ ++L++  ++  E+ +LH+ V    EE
Sbjct: 248 QKTELEEANAKIQADIDYMNEHGPLLDSKQNQELQDLKNHYKKKMEVMDLHRKVNEELEE 307

Query: 467 ARR------------KEEVYKQLMSE---LETLPRDVSRLA-----YTQRILEIVGNIRK 506
           A              KEE+ K +  +   +E   R++ +L      Y+  ++ +  NI +
Sbjct: 308 ALEACENARLKAQQIKEEIDKDIYQDEKTIEAYKREIYQLNSLFDHYSSSVINVNTNIEE 367

Query: 507 QKEEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYK-YLAALHE 565
           ++EE+T+ + +TK  + E++SLS  L+    V D+L +K    ++   +A   + AA   
Sbjct: 368 KEEEVTEAIRETKSSKNELHSLSKMLEDLRRVYDQLTWKQKSHENQYLEAVNDFYAAKKT 427

Query: 566 NCSQLIQTIEDTGTIMREVRDLEE---QIETELGKKTLSNLEKIRE 608
              +L    +D   I      L E   ++E ++ K T+   E IR+
Sbjct: 428 WDIELSDVAKDFSAISLACTKLTEDNKKLEIDINKITVKTNESIRK 473


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 64/324 (19%), Positives = 148/324 (45%), Gaps = 25/324 (7%)

Query: 310  TQVSDVPATSRRPEQVTWAAQEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESEC 369
            T+V  +   SR+ E++   A+E+EL  +RE+       + E+E     L    +Q + + 
Sbjct: 832  TKVKPLLQVSRQEEEMM--AKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQL 889

Query: 370  RHSKLSTAEREQALRLKSRAVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLL 429
            +      AE E+   L++R      +       L+  VE   +R  HL  + +K +  + 
Sbjct: 890  QAETELCAEAEE---LRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQ 946

Query: 430  AEYRHLRKLQDCR---ELESSRRLAEIQELH--------QSVRAAAEEARRKEEV--YKQ 476
                 L + +  R   +LE     A++++L         Q+ + A E+   ++ +  +  
Sbjct: 947  ELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTT 1006

Query: 477  LMSELETLPRDVSRL--AYTQRILEIVGNIRKQKEEITKILSDTKELQKEINSLSGKLDR 534
             ++E E   + +++L   +   I ++   +R+++++  ++    ++L+ +   LS ++  
Sbjct: 1007 NLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAE 1066

Query: 535  TFAVTDELVFKDAKKDDAVRKAYKYLAALHENCSQLIQTIEDTGTIMREVRDLEEQIETE 594
              A   EL  + AKK++ ++ A   LA + E  +Q    ++    +  ++ +L+E +E+E
Sbjct: 1067 LQAQIAELKMQLAKKEEELQAA---LARVEEEAAQKNMALKKIRELESQISELQEDLESE 1123

Query: 595  LGKKTLSNLEK--IREDYRALRQE 616
               +  +  +K  + E+  AL+ E
Sbjct: 1124 RASRNKAEKQKRDLGEELEALKTE 1147



 Score = 53.9 bits (128), Expect = 4e-07
 Identities = 79/326 (24%), Positives = 143/326 (43%), Gaps = 52/326 (15%)

Query: 333  ELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHSKLSTAEREQALRLKSRAVEL 392
            E E LR +L    + +EE+  D++       + E  C+H +    + +Q ++      EL
Sbjct: 898  EAEELRARLTAKKQELEEICHDLEA---RVEEEEERCQHLQAEKKKMQQNIQ------EL 948

Query: 393  LPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQDCR---------- 442
                     + QL  E SA++ + L     + ++  L E + + + Q+C+          
Sbjct: 949  ---------EEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLED 999

Query: 443  -----------ELESSRRLAEIQELHQSVRAAAEEARRKEEVYKQLMS----ELETLPRD 487
                       E E S+ LA+++  H+++    EE  R+EE  +Q +     +LE    D
Sbjct: 1000 RIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTD 1059

Query: 488  VS-RLAYTQ-RILEIVGNIRKQKEEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFK 545
            +S ++A  Q +I E+   + K++EE+   L+  +E   + N    K+    +   EL  +
Sbjct: 1060 LSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQ-E 1118

Query: 546  DAKKDDAVR-KAYKYLAALHENCSQLIQTIEDT---GTIMREVRDLEEQIETELGKKTLS 601
            D + + A R KA K    L E    L   +EDT       +E+R   EQ E  + KKTL 
Sbjct: 1119 DLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQ-EVNILKKTLE 1177

Query: 602  NLEKIRE-DYRALRQENAGLLGRVRE 626
               K  E   + +RQ+++  +  + E
Sbjct: 1178 EEAKTHEAQIQEMRQKHSQAVEELAE 1203



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 60/300 (20%), Positives = 128/300 (42%), Gaps = 28/300 (9%)

Query: 331  EQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHSKLSTAEREQALRLKSRAV 390
            E ++  L+E LE    S  + E   + LG      ++E   +  STA +++    + + V
Sbjct: 1110 ESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEV 1169

Query: 391  ELLP-----DGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQDCRELE 445
             +L      +   + A++Q + +  +Q V  LA Q E+ +        +L K +   E E
Sbjct: 1170 NILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTK----RVKANLEKAKQTLENE 1225

Query: 446  SSRRLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRLAYTQRILEI----- 500
                  E++ L Q    +  + ++ E   ++L  +     R  + LA     L++     
Sbjct: 1226 RGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNV 1285

Query: 501  VGNIRKQKEEITKI----------LSDTKELQKEIN----SLSGKLDRTFAVTDELVFKD 546
             G + +   + +K+          L DT+EL +E N    SLS KL +     +    + 
Sbjct: 1286 TGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQL 1345

Query: 547  AKKDDAVRKAYKYLAALHENCSQLIQTIEDTGTIMREVRDLEEQIETELGKKTLSNLEKI 606
             ++++A     K +A LH   + + + +ED+   +    +++ +++ +L   +  + EK+
Sbjct: 1346 EEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKV 1405



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 79/366 (21%), Positives = 156/366 (42%), Gaps = 60/366 (16%)

Query: 312  VSDVPATSRRPEQVTWAAQEQELESLREQLEG----VNRSIEEVEADMKTLGVSFVQAES 367
            ++D+    RR E+     Q QELE  R +LEG    ++  I E++A +  L +   + E 
Sbjct: 1029 ITDLEERLRREEK-----QRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEE 1083

Query: 368  ECRHSKLSTAEREQALRLKSRAVELLPDGTANLAKLQLVVE------NSAQRVIH-LAGQ 420
            E + + L+  E E A   K+ A++ + +  + +++LQ  +E      N A++    L  +
Sbjct: 1084 ELQ-AALARVEEEAA--QKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEE 1140

Query: 421  WEKHRVPL------LAEYRHLRK--------LQDCRELESSRRLAEIQELHQSVRAAAEE 466
             E  +  L       A  + LR         L+   E E+    A+IQE+ Q    A EE
Sbjct: 1141 LEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEE 1200

Query: 467  ARRKEEVYKQLMSELE----TLPRDVSRLAYTQRIL-------------------EIVGN 503
               + E  K++ + LE    TL  +   LA   ++L                   E+   
Sbjct: 1201 LAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVK 1260

Query: 504  IRKQKEEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYKYLAAL 563
              + +   T++     +LQ E+++++G L ++ + + +L    +  +  ++   + L   
Sbjct: 1261 FNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEE 1320

Query: 564  HE---NCSQLIQTIEDTGTIMREVRDLEEQIETELGKKTLSNLEKIREDYRALRQENAGL 620
            +    + S  ++ +ED     RE  + EE+ +  L +K ++ L     D +   +++ G 
Sbjct: 1321 NRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNL-EKQIATLHAQVADMKKKMEDSVGC 1379

Query: 621  LGRVRE 626
            L    E
Sbjct: 1380 LETAEE 1385



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 63/300 (21%), Positives = 126/300 (42%), Gaps = 50/300 (16%)

Query: 333  ELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHSKLSTAEREQALRLKSRAVEL 392
            E+E L    + V +S+ E+E   + L       E +    K    E E  L+        
Sbjct: 1505 EMEDLMSSKDDVGKSVHELEKSKRAL-------EQQVEEMKTQLEELEDELQ-------- 1549

Query: 393  LPDGTANLAKLQLVVENSAQRV---IHLAGQWEKHRVPLLAEYRHLRKLQDCRELESSRR 449
                    AKL+L V   A +      L G+ E+      +E +  + ++  RE+E    
Sbjct: 1550 ----ATEDAKLRLEVNLQAMKAQFERDLQGRDEQ------SEEKKKQLVRQVREME---- 1595

Query: 450  LAEIQELHQSVRAAAEEARRKEEV-YKQLMSELETLPRDVSRLAYTQRILEI-------- 500
             AE+++  +  R+ A  AR+K E+  K L + +++  ++        R L+         
Sbjct: 1596 -AELED-ERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRE 1653

Query: 501  VGNIRKQKEEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYKYL 560
            + + R  +EE   IL+  KE +K++ S+  ++     + +EL   +  K  A ++  +  
Sbjct: 1654 LDDTRASREE---ILAQAKENEKKLKSMEAEM---IQLQEELAAAERAKRQAQQERDELA 1707

Query: 561  AALHENCSQLIQTIEDTGTIMREVRDLEEQIETELGKKTLSNLEKIREDYRALRQENAGL 620
              +  +  +    +E+   +   +  LEE++E E G   L N +++++    + Q N  L
Sbjct: 1708 DEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELIN-DRLKKANLQIDQINTDL 1766



 Score = 34.7 bits (78), Expect = 0.27
 Identities = 52/260 (20%), Positives = 106/260 (40%), Gaps = 29/260 (11%)

Query: 239  EDTRAQRQRLQKQLTEHLRQSWGLLGAPIQARDLGELLQAWGAGAKTGAPKGSRFTHSEK 298
            +DTRA R+ +  Q  E+ ++   +    IQ ++  EL           A +  R    E+
Sbjct: 1655 DDTRASREEILAQAKENEKKLKSMEAEMIQLQE--EL---------AAAERAKRQAQQER 1703

Query: 299  FTFHLEPQAQATQVSDVPATSRRPEQVTWAAQEQELES-------LREQLEGVNRSIEEV 351
                 +  A ++    +    +R  +   A  E+ELE        + ++L+  N  I+++
Sbjct: 1704 DEL-ADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQI 1762

Query: 352  EADMKTLGVSFVQAESECR------HSKLSTAEREQALRLKSRAVELLPDGTANLAKLQL 405
              D+  L  S  Q     R      + +L    +E    +KS+    +    A +A+L+ 
Sbjct: 1763 NTDLN-LERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEE 1821

Query: 406  VVENSA---QRVIHLAGQWEKHRVPLLAEYRHLRKLQDCRELESSRRLAEIQELHQSVRA 462
             ++N     Q       + EK    +L +    R+  +  + ++ +    +++L + +  
Sbjct: 1822 QLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEE 1881

Query: 463  AAEEARRKEEVYKQLMSELE 482
            A EEA+R     ++L  ELE
Sbjct: 1882 AEEEAQRANASRRKLQRELE 1901



 Score = 32.7 bits (73), Expect = 1.0
 Identities = 58/269 (21%), Positives = 109/269 (40%), Gaps = 12/269 (4%)

Query: 331  EQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHSKLSTAEREQALRLKSRAV 390
            + +++    +L+    S EE+ A  K         E+E    +   A  E+A R   +  
Sbjct: 1644 QAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQER 1703

Query: 391  ELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQDCRELESSRRL 450
            + L D  AN +    +     +R+     Q E+     L E +   +L + R  +++ ++
Sbjct: 1704 DELADEIANSSGKGALALEEKRRLEARIAQLEEE----LEEEQGNTELINDRLKKANLQI 1759

Query: 451  AEIQ---ELHQSVRAAAEEARRK-EEVYKQLMSELETLPRDVSRLAYTQRILEIVGNIRK 506
             +I     L +S     E AR++ E   K+L  +L+ +   V +  Y   I  +   I +
Sbjct: 1760 DQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTV-KSKYKASITALEAKIAQ 1818

Query: 507  QKEEITKILSDTKELQKEINSLSGKL-DRTFAVTDELVFKDAKKDDAVRKAYKYLAALHE 565
             +E++     + +   K++     KL D    V DE    +  KD A  KA   L  L  
Sbjct: 1819 LEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQA-DKASTRLKQLKR 1877

Query: 566  NCSQLIQTIEDTGTIMREV-RDLEEQIET 593
               +  +  +      R++ R+LE+  ET
Sbjct: 1878 QLEEAEEEAQRANASRRKLQRELEDATET 1906


>gi|38044112 restin isoform b [Homo sapiens]
          Length = 1392

 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 62/318 (19%), Positives = 139/318 (43%), Gaps = 52/318 (16%)

Query: 331  EQELESLREQLEGVNRSIE--EVEADMKTLGVSFVQAESECRHSKLST-----AEREQAL 383
            + E++ LR+QLE   + I+  E+E + ++   S +  E + R  KL+      +E  Q  
Sbjct: 741  KSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVK 800

Query: 384  RLKSRAVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQDCRE 443
                + +++L +  A  ++  + V+ S Q  ++   Q                     +E
Sbjct: 801  ETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQ---------------------KE 839

Query: 444  LESSRRLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRLAYTQRILEIVGN 503
             + +   +++++L +++     + R K+E  +QL+   E L  D++       I+++ G+
Sbjct: 840  EQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIA------EIMKMSGD 893

Query: 504  IRKQKEEITKILSDTKELQKEINSLSGKLDRT--------FAVTDELVFKDAKKDDAVRK 555
                  ++TK+  + +  ++++  L  KL +          ++ D  V  +  + +A +K
Sbjct: 894  ---NSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKK 950

Query: 556  AYKYLAALHENCSQLIQTIEDTGTIMREVRDLEEQIETELGKK---TLSNLEK----IRE 608
              +    L    S L + +E +    +E++   E+  +E   K    L NL+K      +
Sbjct: 951  HEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTED 1010

Query: 609  DYRALRQENAGLLGRVRE 626
              +  R+EN+GLL  + E
Sbjct: 1011 KLKGAREENSGLLQELEE 1028



 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 62/321 (19%), Positives = 129/321 (40%), Gaps = 49/321 (15%)

Query: 312  VSDVPATSRRPEQVTWAAQEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECR- 370
            + D+   + + +Q      E+E + L  +L  + + +E      + L   + +A SE + 
Sbjct: 933  IEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKT 992

Query: 371  -HSKLSTAEREQALRLKSRAVELLPDGTANLAKLQLV--------VENSAQRVIHLAGQW 421
             H ++    ++  L  + +      + +  L +L+ +           +A+  + +  Q 
Sbjct: 993  KHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQM 1052

Query: 422  EKHRVPLLAEYRHLR----KLQDCRELESSRRLAEIQELHQSVRAAAEEARRKEEVYKQL 477
             K +   LA     +    KLQ+  +      L  ++EL++S      E ++ EE  K  
Sbjct: 1053 TKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRK-- 1110

Query: 478  MSELETLPRDVSRLAYTQRILEIVGNIRKQKEEITKILSDTKELQKEINSLSGKLDRTFA 537
              E+ETL +  ++ +     L+         EE  K+  +    + E+ S   KL+   +
Sbjct: 1111 --EIETLKQAAAQKSQQLSALQ---------EENVKLAEELGRSRDEVTSHQ-KLEEERS 1158

Query: 538  VTDELVFKDAKKDDAVRKAYKYLAALHENCSQLIQTIEDTGTIMREVRDLEEQIETELGK 597
            V +  + +  K++       K++    E  + L ++I  T  ++ E +D E         
Sbjct: 1159 VLNNQLLEMKKRES------KFIKDADEEKASLQKSISITSALLTE-KDAE--------- 1202

Query: 598  KTLSNLEKIREDYRALRQENA 618
                 LEK+R +   LR ENA
Sbjct: 1203 -----LEKLRNEVTVLRGENA 1218



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 59/298 (19%), Positives = 123/298 (41%), Gaps = 45/298 (15%)

Query: 333  ELESLREQLEGVNRSIEEVEADMKTLG--VSFVQAESECRHSKLSTAEREQALRLKSRAV 390
            +L  + ++L    R +EE++  +       SF+Q   E    K   +++E A + +    
Sbjct: 897  QLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKK 956

Query: 391  ELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQDCRELESSRRL 450
            EL       L+ L+  +E S  +   L  ++E+       ++  +               
Sbjct: 957  EL----ERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEI--------------- 997

Query: 451  AEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPR--DVSRLAYT-QRILEIVGNIRKQ 507
              +Q L +++    ++ +   E    L+ ELE L +  D ++ A T +  ++I+  + K+
Sbjct: 998  --LQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKE 1055

Query: 508  KEEITKILSDTKE----LQKEINSLSG---KLDRTFAVTDELVFKDAKKDDAVRKAYKYL 560
            K E    L DTK+    LQ E+++L     K       + EL+  + +K +  RK  + L
Sbjct: 1056 KTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETL 1115

Query: 561  AALHENCSQLIQTIEDTGTIMREVRDLEEQIETELGKK--TLSNLEKIREDYRALRQE 616
                   SQ +  +++    + E          ELG+    +++ +K+ E+   L  +
Sbjct: 1116 KQAAAQKSQQLSALQEENVKLAE----------ELGRSRDEVTSHQKLEEERSVLNNQ 1163



 Score = 39.7 bits (91), Expect = 0.008
 Identities = 65/309 (21%), Positives = 119/309 (38%), Gaps = 27/309 (8%)

Query: 324 QVTWAAQEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHSKLSTAEREQAL 383
           +VT    ++E+ SL+E   G      + E          +  E+E   SKL  A +E   
Sbjct: 514 EVTRTDHQREITSLKEHF-GAREETHQKEIKALYTATEKLSKENESLKSKLEHANKEN-- 570

Query: 384 RLKSRAVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQDCRE 443
              S  + L        +KL+  + +  Q +  L   + K      AE+  L+   +   
Sbjct: 571 ---SDVIALWK------SKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMR 621

Query: 444 LESSRRLAEIQELHQSVRAA----AEEARRK-EEVYKQLMSELETLPRDVSRLAYTQRIL 498
           L+    +  +Q    S RAA     E  R K  +V K+  + LE +   + + A  Q ++
Sbjct: 622 LDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDK-AEDQHLV 680

Query: 499 EIVGNIRKQKEEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYK 558
           E+   + K +E   K+        KE+  L  K +    V D    +    ++ +     
Sbjct: 681 EMEDTLNKLQEAEIKV--------KELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDA 732

Query: 559 YLAALHENCSQLIQTIEDTGTIMREVRDLEEQIETELGKKTLSNLE-KIREDYRALRQEN 617
              A  E  S++ +  +      ++++ LE +   E  K +    E + RE      QEN
Sbjct: 733 LRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQEN 792

Query: 618 AGLLGRVRE 626
              + +V+E
Sbjct: 793 LSEVSQVKE 801


>gi|4506751 restin isoform a [Homo sapiens]
          Length = 1427

 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 62/318 (19%), Positives = 139/318 (43%), Gaps = 52/318 (16%)

Query: 331  EQELESLREQLEGVNRSIE--EVEADMKTLGVSFVQAESECRHSKLST-----AEREQAL 383
            + E++ LR+QLE   + I+  E+E + ++   S +  E + R  KL+      +E  Q  
Sbjct: 776  KSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVK 835

Query: 384  RLKSRAVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQDCRE 443
                + +++L +  A  ++  + V+ S Q  ++   Q                     +E
Sbjct: 836  ETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQ---------------------KE 874

Query: 444  LESSRRLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRLAYTQRILEIVGN 503
             + +   +++++L +++     + R K+E  +QL+   E L  D++       I+++ G+
Sbjct: 875  EQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIA------EIMKMSGD 928

Query: 504  IRKQKEEITKILSDTKELQKEINSLSGKLDRT--------FAVTDELVFKDAKKDDAVRK 555
                  ++TK+  + +  ++++  L  KL +          ++ D  V  +  + +A +K
Sbjct: 929  ---NSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKK 985

Query: 556  AYKYLAALHENCSQLIQTIEDTGTIMREVRDLEEQIETELGKK---TLSNLEK----IRE 608
              +    L    S L + +E +    +E++   E+  +E   K    L NL+K      +
Sbjct: 986  HEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTED 1045

Query: 609  DYRALRQENAGLLGRVRE 626
              +  R+EN+GLL  + E
Sbjct: 1046 KLKGAREENSGLLQELEE 1063



 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 62/321 (19%), Positives = 129/321 (40%), Gaps = 49/321 (15%)

Query: 312  VSDVPATSRRPEQVTWAAQEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECR- 370
            + D+   + + +Q      E+E + L  +L  + + +E      + L   + +A SE + 
Sbjct: 968  IEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKT 1027

Query: 371  -HSKLSTAEREQALRLKSRAVELLPDGTANLAKLQLV--------VENSAQRVIHLAGQW 421
             H ++    ++  L  + +      + +  L +L+ +           +A+  + +  Q 
Sbjct: 1028 KHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQM 1087

Query: 422  EKHRVPLLAEYRHLR----KLQDCRELESSRRLAEIQELHQSVRAAAEEARRKEEVYKQL 477
             K +   LA     +    KLQ+  +      L  ++EL++S      E ++ EE  K  
Sbjct: 1088 TKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRK-- 1145

Query: 478  MSELETLPRDVSRLAYTQRILEIVGNIRKQKEEITKILSDTKELQKEINSLSGKLDRTFA 537
              E+ETL +  ++ +     L+         EE  K+  +    + E+ S   KL+   +
Sbjct: 1146 --EIETLKQAAAQKSQQLSALQ---------EENVKLAEELGRSRDEVTSHQ-KLEEERS 1193

Query: 538  VTDELVFKDAKKDDAVRKAYKYLAALHENCSQLIQTIEDTGTIMREVRDLEEQIETELGK 597
            V +  + +  K++       K++    E  + L ++I  T  ++ E +D E         
Sbjct: 1194 VLNNQLLEMKKRES------KFIKDADEEKASLQKSISITSALLTE-KDAE--------- 1237

Query: 598  KTLSNLEKIREDYRALRQENA 618
                 LEK+R +   LR ENA
Sbjct: 1238 -----LEKLRNEVTVLRGENA 1253



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 59/298 (19%), Positives = 123/298 (41%), Gaps = 45/298 (15%)

Query: 333  ELESLREQLEGVNRSIEEVEADMKTLG--VSFVQAESECRHSKLSTAEREQALRLKSRAV 390
            +L  + ++L    R +EE++  +       SF+Q   E    K   +++E A + +    
Sbjct: 932  QLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKK 991

Query: 391  ELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQDCRELESSRRL 450
            EL       L+ L+  +E S  +   L  ++E+       ++  +               
Sbjct: 992  EL----ERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEI--------------- 1032

Query: 451  AEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPR--DVSRLAYT-QRILEIVGNIRKQ 507
              +Q L +++    ++ +   E    L+ ELE L +  D ++ A T +  ++I+  + K+
Sbjct: 1033 --LQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKE 1090

Query: 508  KEEITKILSDTKE----LQKEINSLSG---KLDRTFAVTDELVFKDAKKDDAVRKAYKYL 560
            K E    L DTK+    LQ E+++L     K       + EL+  + +K +  RK  + L
Sbjct: 1091 KTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETL 1150

Query: 561  AALHENCSQLIQTIEDTGTIMREVRDLEEQIETELGKK--TLSNLEKIREDYRALRQE 616
                   SQ +  +++    + E          ELG+    +++ +K+ E+   L  +
Sbjct: 1151 KQAAAQKSQQLSALQEENVKLAE----------ELGRSRDEVTSHQKLEEERSVLNNQ 1198



 Score = 39.7 bits (91), Expect = 0.008
 Identities = 65/309 (21%), Positives = 119/309 (38%), Gaps = 27/309 (8%)

Query: 324 QVTWAAQEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHSKLSTAEREQAL 383
           +VT    ++E+ SL+E   G      + E          +  E+E   SKL  A +E   
Sbjct: 549 EVTRTDHQREITSLKEHF-GAREETHQKEIKALYTATEKLSKENESLKSKLEHANKEN-- 605

Query: 384 RLKSRAVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQDCRE 443
              S  + L        +KL+  + +  Q +  L   + K      AE+  L+   +   
Sbjct: 606 ---SDVIALWK------SKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMR 656

Query: 444 LESSRRLAEIQELHQSVRAA----AEEARRK-EEVYKQLMSELETLPRDVSRLAYTQRIL 498
           L+    +  +Q    S RAA     E  R K  +V K+  + LE +   + + A  Q ++
Sbjct: 657 LDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDK-AEDQHLV 715

Query: 499 EIVGNIRKQKEEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYK 558
           E+   + K +E   K+        KE+  L  K +    V D    +    ++ +     
Sbjct: 716 EMEDTLNKLQEAEIKV--------KELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDA 767

Query: 559 YLAALHENCSQLIQTIEDTGTIMREVRDLEEQIETELGKKTLSNLE-KIREDYRALRQEN 617
              A  E  S++ +  +      ++++ LE +   E  K +    E + RE      QEN
Sbjct: 768 LRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQEN 827

Query: 618 AGLLGRVRE 626
              + +V+E
Sbjct: 828 LSEVSQVKE 836


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 102/451 (22%), Positives = 177/451 (39%), Gaps = 49/451 (10%)

Query: 194  TQVPQPVGRVASLLEHHALQLCQQT----GRDRPGDEDWVHRTSRLPPQEDTRAQRQRLQ 249
            T +   +  + + ++   LQL ++     G    GD++ +H+ + L    + +AQ   LQ
Sbjct: 1065 TDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQ 1124

Query: 250  KQLTEHLRQSWGLLGAPIQARDLGELLQAWGAGAK-----TGAPKGSRFTHSEKFTFHLE 304
            +       +      A  Q RDL E L+A     +     T A +  R    ++     +
Sbjct: 1125 EDFES---EKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKK 1181

Query: 305  PQAQATQVSDVPATSRRPEQVTWAAQEQELESLREQLE-------GVNRSIEEVEADMKT 357
               + T+  +      R    T       LE L EQLE        + ++ + +E D K 
Sbjct: 1182 ALEEETKNHEAQIQDMRQRHAT------ALEELSEQLEQAKRFKANLEKNKQGLETDNKE 1235

Query: 358  LG-----VSFVQAESECRHSKLSTAEREQALRLKSRAVELLPDGTANLAKLQLVVENSAQ 412
            L      +  V+AESE +  KL    +E   ++ S    L  +     +KLQ    N   
Sbjct: 1236 LACEVKVLQQVKAESEHKRKKLDAQVQELHAKV-SEGDRLRVELAEKASKLQ----NELD 1290

Query: 413  RVIHLAGQWEKHRVPLLAEYRHLR-KLQDCREL---ESSRRL---AEIQELHQSVRAAAE 465
             V  L  + EK  +    +   L  +LQD +EL   E+ ++L   + I++L +   +  E
Sbjct: 1291 NVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQE 1350

Query: 466  EARRKEEVYKQLMSELETLPRDVSRLAYT-QRILEIVGNIRKQKEEITKILSDTKELQKE 524
            +   +EE  K L  ++  L    S+LA T +++ + +G I   +E   K+L D + L + 
Sbjct: 1351 QQEEEEEARKNLEKQVLALQ---SQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQR 1407

Query: 525  INSLSGKLDRTFAVTDEL--VFKDAKKD-DAVRKAYKYLAALHENCSQLIQTIEDTGTIM 581
            +   +   D+     + L     D   D D  R+    L    +   QL+   +      
Sbjct: 1408 LEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARY 1467

Query: 582  REVRDLEEQIETELGKKTLSNLEKIREDYRA 612
             E RD  E    E   K LS    + E   A
Sbjct: 1468 AEERDRAEAEAREKETKALSLARALEEALEA 1498



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 65/326 (19%), Positives = 144/326 (44%), Gaps = 29/326 (8%)

Query: 310  TQVSDVPATSRRPEQVTWAAQEQELESLREQLEGVNRSIEEVEAD-MKTLGVSFVQAESE 368
            T+V  +   +R+ E++   A+++EL  ++E+   V   +EE+E    + L    + AE  
Sbjct: 839  TKVKPLLQVTRQEEELQ--AKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQL 896

Query: 369  CRHSKLSTAEREQALRLKSRAVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPL 428
               ++L     E   RL ++  EL       L  L+  VE   +R   L  + +K +  +
Sbjct: 897  QAETELFAEAEEMRARLAAKKQEL----EEILHDLESRVEEEEERNQILQNEKKKMQAHI 952

Query: 429  LAEYRHLRKLQDCRE---LESSRRLAEIQELHQSVRAAAEEARRKEEVYKQLM------- 478
                  L + +  R+   LE     A+I+++ + +    E+   K    K+LM       
Sbjct: 953  QDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEI-LLLEDQNSKFIKEKKLMEDRIAEC 1011

Query: 479  ----SELETLPRDVSRLAYTQRIL--EIVGNIRKQKEEITKILSDTKELQKEINSLSGKL 532
                +E E   ++++++   Q ++  ++   ++K+++   ++    ++L  E   L  ++
Sbjct: 1012 SSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQI 1071

Query: 533  DRTFAVTDELVFKDAKKDDAVRKAYKYLAALHENCSQLIQTIEDTGTIMREVRDLEEQIE 592
                A  DEL  + AKK++ ++ A   LA   +        ++    +  ++ +L+E  E
Sbjct: 1072 AELQAQIDELKLQLAKKEEELQGA---LARGDDETLHKNNALKVVRELQAQIAELQEDFE 1128

Query: 593  TELGKKTLSNLEK--IREDYRALRQE 616
            +E   +  +  +K  + E+  AL+ E
Sbjct: 1129 SEKASRNKAEKQKRDLSEELEALKTE 1154



 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 38/192 (19%), Positives = 83/192 (43%), Gaps = 26/192 (13%)

Query: 430 AEYRHLRKLQDCRELESSRRLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVS 489
           A Y  LR  Q  R     + L ++    + ++A  EE  + +E   ++  ELE + R   
Sbjct: 824 AAYLKLRHWQWWRVFTKVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERK-- 881

Query: 490 RLAYTQRILEIVGNIRKQKEEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKK 549
                Q++LE    + +Q +  T++ ++ +E++  + +   +L+      +  V ++ ++
Sbjct: 882 ----HQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEER 937

Query: 550 DDAVRKAYKYLAALHENCSQLIQTIEDTGTIMREVRDLEEQIETELGKKTLSNLEKIRED 609
           +  ++   K + A                     ++DLEEQ++ E G +    LEK+  +
Sbjct: 938 NQILQNEKKKMQA--------------------HIQDLEEQLDEEEGARQKLQLEKVTAE 977

Query: 610 YRALRQENAGLL 621
            +  + E   LL
Sbjct: 978 AKIKKMEEEILL 989



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 79/325 (24%), Positives = 133/325 (40%), Gaps = 54/325 (16%)

Query: 328  AAQEQELESLREQLEGVNRSIEE-----------VEADMKTLGVSFVQAESECRHSKLST 376
            AA++QELE +   LE      EE           ++A ++ L     + E   +  +L  
Sbjct: 914  AAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEK 973

Query: 377  AEREQALRLKSRAVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLR 436
               E  ++     + LL D  +   K + ++E+   R+   + Q        LAE     
Sbjct: 974  VTAEAKIKKMEEEILLLEDQNSKFIKEKKLMED---RIAECSSQ--------LAE----- 1017

Query: 437  KLQDCRELESSRRLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVS------- 489
                  E E ++ LA+I+   + + +  EE  +KEE  +Q   ELE   R +        
Sbjct: 1018 ------EEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQ---ELEKAKRKLDGETTDLQ 1068

Query: 490  -RLAYTQ-RILEIVGNIRKQKEEITKILS--DTKELQKEINSLSGKLDRTFAVTDELVFK 545
             ++A  Q +I E+   + K++EE+   L+  D + L K  N+L  K+ R        + +
Sbjct: 1069 DQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKN-NAL--KVVRELQAQIAELQE 1125

Query: 546  DAKKDDAVR-KAYKYLAALHENCSQLIQTIEDT---GTIMREVRDLEEQIETELGKKTLS 601
            D + + A R KA K    L E    L   +EDT       +E+R   EQ   EL K    
Sbjct: 1126 DFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEE 1185

Query: 602  NLEKIREDYRALRQENAGLLGRVRE 626
              +      + +RQ +A  L  + E
Sbjct: 1186 ETKNHEAQIQDMRQRHATALEELSE 1210



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 75/333 (22%), Positives = 137/333 (41%), Gaps = 71/333 (21%)

Query: 306  QAQATQVSDVPATSRRPEQVTWAAQEQ--ELESLREQLEGVNRSIEEVEADMKTL---GV 360
            Q +  Q  ++ +  R+ E+   + QEQ  E E  R+ LE    +++   AD K      +
Sbjct: 1325 QEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDL 1384

Query: 361  SFVQAESECRHSKLSTAE------REQAL------RLKSRAVELLPDGTANLAKLQLVVE 408
              +++  E +   L  AE       E+AL      + K+R  + L D T +L   + V  
Sbjct: 1385 GTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVAS 1444

Query: 409  NSAQRVIHLAGQWEKHRVPLLAEYRHLR----KLQDCRELESSRRLAEIQELHQSVRAAA 464
            N  ++        +K    LLAE + +     + +D  E E+  +  +   L +++  A 
Sbjct: 1445 NLEKK--------QKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEAL 1496

Query: 465  EEARRKEEVYKQLMSELETLP-------RDVSRLAYTQRILEI-VGNIRKQKEEITKILS 516
            E     E   KQL +++E L        ++V  L  ++R LE  V  +R Q EE+   L 
Sbjct: 1497 EAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQ 1556

Query: 517  DTKE--LQKEIN--SLSGKLDRTFAVTDELVFKDAKKDDAVRKAYKYLAALHENCSQLIQ 572
             T++  L+ E+N  ++  + +R     DE                              Q
Sbjct: 1557 ATEDAKLRLEVNMQAMKAQFERDLQTRDE------------------------------Q 1586

Query: 573  TIEDTGTIMREVRDLEEQIETELGKKTLSNLEK 605
              E    ++++VR+LE ++E E  ++ L+   K
Sbjct: 1587 NEEKKRLLIKQVRELEAELEDERKQRALAVASK 1619



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 65/317 (20%), Positives = 124/317 (39%), Gaps = 49/317 (15%)

Query: 331  EQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHSKLSTAE-----REQALRL 385
            E +L+ L  Q+E  N++ +EV   ++ L       + E   ++ S  E     +E   +L
Sbjct: 1623 EIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKL 1682

Query: 386  KSRAVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQDCRELE 445
            KS   E+L        +LQ  + +S +   H     E+ R  L  E  +    +     E
Sbjct: 1683 KSLEAEIL--------QLQEELASSERARRHA----EQERDELADEITNSASGKSALLDE 1730

Query: 446  SSRRLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRLAYTQRILEIVGNIR 505
              R  A I +L + +           + +++   +++TL    + LA  +   +   N R
Sbjct: 1731 KRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLN---AELAAERSAAQKSDNAR 1787

Query: 506  KQKEEITKILSDTKELQKEINSLSGKLDRTFAVT-----------DELVFKDAKKDDA-- 552
            +Q E         KEL+ ++  L G +   F  T           +E + ++AK+  A  
Sbjct: 1788 QQLER------QNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAAN 1841

Query: 553  --VRKAYKYLAAL-------HENCSQLIQTIEDTGTIMREVRDLEEQIETELGKKTLSNL 603
              VR+  K L  +         +  Q  + +E     M++++   E+ E E  +   S  
Sbjct: 1842 KLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASR- 1900

Query: 604  EKIREDYRALRQENAGL 620
             K++ +     + N GL
Sbjct: 1901 RKLQRELDDATEANEGL 1917


>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
          Length = 2115

 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 94/402 (23%), Positives = 178/402 (44%), Gaps = 42/402 (10%)

Query: 244 QRQRLQKQLTEHLRQSWGLLGAPIQARDLGELLQAWGA-GAKTGAPKGSRFTHSEKFTFH 302
           ++Q+L   +T+ L+ S   L    QA++  EL QA  A GA+  A   S    SE  T +
Sbjct: 460 EKQQLSSLITD-LQSSISNLS---QAKE--ELEQASQAHGARLTAQVAS--LTSELTTLN 511

Query: 303 LEPQAQATQVSDVPATSRRPEQV---TWAAQEQELESLREQLEGVNRSIEEVEADMKTLG 359
              Q Q  +++ +   ++  +     T   QEQ  + LR Q+E ++ S+++ E  +K + 
Sbjct: 512 ATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVA 571

Query: 360 VSFVQAESECRHSKLSTA--EREQALRLKSRAVELL----PDGTANLAKL--QLVVENSA 411
               +A  +    +L+TA  ERE +LR +  A++ L     +  A L  L  QL V N A
Sbjct: 572 EK-QEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEA 630

Query: 412 QRVIHLA-GQWEKHRVPLLAEYRHLRKLQDCRELESSRRLAEIQELHQSVRAAAEEARRK 470
           +     +  Q ++ +  L  +   L+   +    E     A++ EL   +R+  ++A  K
Sbjct: 631 RDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEK 690

Query: 471 EEVYK---QLMSELETLPRD--VSRLAYTQRILEIVGNIRKQKEEITKILSDTKELQKEI 525
           E V +   QL  +L+ L     V++ +  +        + +Q+  I+++ ++T+ L ++ 
Sbjct: 691 ERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQH 750

Query: 526 NSLSGKLDRTFAVTDELVFK--------DAKKDDAVRKAYKYLAALH---ENCSQLIQTI 574
                +L+   A    L  +         A+ +   R+  + +AA H     C QL++ +
Sbjct: 751 KRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEV 810

Query: 575 EDTGTIMREVRDLEEQIETELGKKTLSNLEKIREDYRALRQE 616
                  RE  +  +Q E + G      L  ++E+    RQE
Sbjct: 811 ----AAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQE 848



 Score = 47.0 bits (110), Expect = 5e-05
 Identities = 74/320 (23%), Positives = 137/320 (42%), Gaps = 41/320 (12%)

Query: 212 LQLCQQTGRDRPGDEDWVHRTSRLPPQEDTRAQRQRLQKQLTEHLRQSWGLLGAPIQARD 271
           LQ C +T R                 Q + +AQ   L+ QL    +++        +   
Sbjct: 655 LQACVETARQE---------------QHEAQAQVAELELQLRSEQQKATEKERVAQEKDQ 699

Query: 272 LGELLQAWGAGAKTGAPKGSRFTHSEKFTFHLEPQAQATQVSDVPATSRRPEQVTWAAQE 331
           L E LQA     K    KGS      +    LE Q +   +S++ A +R         ++
Sbjct: 700 LQEQLQALKESLKV--TKGSLEEEKRRAADALEEQQRC--ISELKAETRS------LVEQ 749

Query: 332 QELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHSKLSTAEREQALRLKSRAVE 391
            + E  R++LE      + +EA ++ LG +  QAE+E    +L+ A   Q    +S   +
Sbjct: 750 HKRE--RKELEEERAGRKGLEARLQQLGEAH-QAETEVLRRELAEAMAAQHTA-ESECEQ 805

Query: 392 LLPDGTANLAKLQLVVENSAQ-------RVIHLAGQWEKHRVPLLAEYRHLRKLQDCREL 444
           L+ +  A   + +   +  AQ       +++ L  + EK R  L      +  ++   EL
Sbjct: 806 LVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSEL 865

Query: 445 ESSRRLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRLAYTQRILEIVGNI 504
           + SR+  E+ ELH ++  A ++ + KE   ++L  +L TL   ++  A ++ +  +   +
Sbjct: 866 QISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMA--ATSKEVARLETLV 923

Query: 505 RKQKEEITKILSDTKELQKE 524
           RK  E+     + ++EL KE
Sbjct: 924 RKAGEQQE---TASRELVKE 940



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 74/356 (20%), Positives = 149/356 (41%), Gaps = 60/356 (16%)

Query: 317  ATSRRPEQVTWAAQEQELE--SLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHSKL 374
            A  R+PE   W  ++Q  +  S +  L+ + R  E++  +++ L  + ++++ + +  + 
Sbjct: 944  AGDRQPE---WLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEER- 999

Query: 375  STAEREQA--LRLKSRAVELLPDGTANLAKLQLVVENSA-QRVIHLAGQWEKHRVPLLAE 431
               ERE A   + + RA   L    A  A+L++ ++N+  ++ +  A   E     L  +
Sbjct: 1000 GQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEK 1059

Query: 432  YRHLRKLQDCRELESSRRLAEIQELHQSVRAAAEEARRKEEVY--------------KQL 477
                ++L   R LE+++ + E++EL Q+V+   E+  +KE+ +              +  
Sbjct: 1060 EGKDQELAKLRGLEAAQ-IKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPT 1118

Query: 478  MSELETLPRDVSRLAY-----------TQRILE---------------IVGNIRKQKEEI 511
              +LE L  +VS+L              +R LE               + G + ++ +E+
Sbjct: 1119 GPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQEL 1178

Query: 512  TKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYKYLAALHENCSQL- 570
                S     Q+E+ +   K+       DE   + A+      +    +++L E  S L 
Sbjct: 1179 GHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILN 1238

Query: 571  IQTIEDTGTIMREVRDLEEQIETELGKKTLSNLEKIREDYRALRQENAGLLGRVRE 626
             Q +E  G    E ++L+  +  E  K      +K+ E  R L+ E A    R  E
Sbjct: 1239 RQVLEKEG----ESKELKRLVMAESEKS-----QKLEERLRLLQAETASNSARAAE 1285



 Score = 37.7 bits (86), Expect = 0.032
 Identities = 91/434 (20%), Positives = 184/434 (42%), Gaps = 46/434 (10%)

Query: 204  ASLLEHHALQLCQQTGRDRPGDEDWVHRTSRLPPQEDTRAQRQRLQKQLTEHLRQSWGLL 263
            A+L E  A  L ++ G+D+   +      +++   E+ R   ++L++QL +  ++     
Sbjct: 1046 ATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGS 1105

Query: 264  GAPIQARDLGELLQAWGAGAKTGAPKGSRFTHSEKFTFHLEPQAQATQV-SDVPATSRRP 322
            GA  +A    E             P G +          LE Q Q  Q  +D    S   
Sbjct: 1106 GAQSEAAGRTE-------------PTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEA 1152

Query: 323  EQVTWAAQEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECR-HSKLSTAEREQ 381
            E+ + A ++  LE+L+ QLE   + +   ++ + +         ++ + HSK     + Q
Sbjct: 1153 ERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQ 1212

Query: 382  ALRLKSRAVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQDC 441
              R +  A        + ++ L+  V    ++V+   G+ ++ +  ++AE    +KL   
Sbjct: 1213 VARGRQEAERK----NSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKL--- 1265

Query: 442  RELESSRRLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRLAYTQRILEIV 501
               E   RL + +    S RAA   +  +EEV + L  E E       R+A ++ + + +
Sbjct: 1266 ---EERLRLLQAETASNSARAAERSSALREEV-QSLREEAEK-----QRVA-SENLRQEL 1315

Query: 502  GNIRKQKEEITKILSDTKE--LQKE--INSLSGKLDRTFAVTDELVFKDAKKDDAVRKAY 557
             +  ++ EE+ + L   +E   QKE  +++L  +   T A+  EL+     K    +   
Sbjct: 1316 TSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELL---PAKHLCQQLQA 1372

Query: 558  KYLAALHENCSQLIQTIEDTG----TIMREVRDLEEQIETELGKKTLSNLEKIREDYRAL 613
            +  AA   +  +L Q+ +  G     ++R  R+L E I     ++ ++  E+  +  RA 
Sbjct: 1373 EQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPL---RQKVAEQERTAQQLRAE 1429

Query: 614  RQENAGLLGRVREA 627
            +   A  L  +++A
Sbjct: 1430 KASYAEQLSMLKKA 1443


>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
          Length = 1417

 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 66/288 (22%), Positives = 125/288 (43%), Gaps = 34/288 (11%)

Query: 332  QELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHSKLSTAEREQALRLKSRAVE 391
            ++L+ LR+ L+    S+EE    +K L     + + E    K    E +QAL  K R  E
Sbjct: 1081 RQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQAL--KERNWE 1138

Query: 392  LLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQDCRELESSRRLA 451
            L               +  A +V HL     +HR  +  +   L    +  ELE      
Sbjct: 1139 L---------------KQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNK 1183

Query: 452  EIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRLAYTQRILEIVGNIRKQKEEI 511
            +I+ L+  ++ A E+ R KE +  Q   E+  L +++ R    QR+ E+   +++Q++ I
Sbjct: 1184 QIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERT--QQRMKEMESVMKEQEQYI 1241

Query: 512  TKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDA-VRKAYKYLAALHENCSQL 570
                 +  +L +E+     +L R           +A+      ++  + L++  E+  QL
Sbjct: 1242 ATQYKEAIDLGQEL-----RLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQL 1296

Query: 571  IQTIEDTGTIMRE------VRD--LEEQIETELGKKTLSNLEKIREDY 610
             +  +  G  + E      VR+  LE +++ E+ KK  + +E ++E Y
Sbjct: 1297 SKEKDAHGNHLAEELGASKVREAHLEARMQAEI-KKLSAEVESLKEAY 1343



 Score = 38.5 bits (88), Expect = 0.019
 Identities = 61/306 (19%), Positives = 118/306 (38%), Gaps = 18/306 (5%)

Query: 330  QEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHSKLSTAEREQALRLKSRA 389
            + +E+  L+++L+  N S++E       L  +  Q +   +   +   E E       + 
Sbjct: 879  KSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQ 938

Query: 390  V-----ELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQDCREL 444
            V     EL     ++  KL+ + E   +   H A    +  + L    R ++   D  + 
Sbjct: 939  VSKLEQELQKQRESSAEKLRKM-EEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKE 997

Query: 445  ESSRRLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRLAYTQRILEIVGNI 504
            E S+   EI  L +     A    + + +  Q  +ELE     V  L   Q   E     
Sbjct: 998  ELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTET---- 1053

Query: 505  RKQKEEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYKYLAALH 564
                 E+T+ L   + L+ E+ +  G+L  T     EL     K   ++ + Y  +  L 
Sbjct: 1054 -----ELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLT 1108

Query: 565  ENCSQLIQTIEDTGTIMREVRDLEEQIETELGKKT--LSNLE-KIREDYRALRQENAGLL 621
                +    IED    + E+    ++   EL ++   +++L+  IRE    + Q+   L 
Sbjct: 1109 AELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLE 1168

Query: 622  GRVREA 627
            G + ++
Sbjct: 1169 GTLEKS 1174



 Score = 37.4 bits (85), Expect = 0.042
 Identities = 63/307 (20%), Positives = 120/307 (39%), Gaps = 42/307 (13%)

Query: 331 EQELESLREQLEGVNRSIEEVEADMKTLGV----------SFVQAESEC----RHSKLST 376
           +QE+ES R +L  + + I ++    +  G           SF   E  C      +KL  
Sbjct: 500 QQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVI 559

Query: 377 AEREQALRLKSRAVELLPDG-TANLAKLQLVVENSAQRVIHLAGQWEK------HRVPLL 429
           +E    L +K   ++ L    TAN     L+  N +Q    L+    +      H+V   
Sbjct: 560 SELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAES 619

Query: 430 AEYRHLRKLQDCRELESSRRLAEIQELHQS-VRAAAEEARRKEEVYKQLMSELETLPRDV 488
            + ++   +    E E  R +  I+EL    ++  AE +  K  +  +  S+ + +  + 
Sbjct: 620 VKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRT-SQFQLIQEE- 677

Query: 489 SRLAYTQRILEIVGNIRKQKEEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAK 548
                   +LE   N  K + E+TK  S    L+K++           A   EL  +  +
Sbjct: 678 --------LLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELME 729

Query: 549 KDDAVRKAYKYLAALHENCSQLIQT-----IEDTGTIMREVRDLEEQIET-----ELGKK 598
           K++ +R     +   HE      +      +E    + +++  LE Q+E      +  +K
Sbjct: 730 KNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEK 789

Query: 599 TLSNLEK 605
           T+S L++
Sbjct: 790 TMSMLQQ 796



 Score = 36.6 bits (83), Expect = 0.072
 Identities = 54/276 (19%), Positives = 119/276 (43%), Gaps = 21/276 (7%)

Query: 328 AAQEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHSKLSTAEREQALRLKS 387
           A  +QE++SLRE+L  + +    +     +L   F     E   S+   +  E A + ++
Sbjct: 225 APVDQEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESA-QQQA 283

Query: 388 RAVELLPDGTANLAKLQLVVENSAQ-RVIHLAGQWEKHRVPLLAEYRHLRKLQDCRELES 446
            +V +L +   NL       E SAQ +V+  A    +    ++ E     K Q  +E + 
Sbjct: 284 ASVPILEEQIINLE-----AEVSAQDKVLREAENKLEQSQKMVIE-----KEQSLQESKE 333

Query: 447 SRRLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRLAYTQRILEIVGNIRK 506
                ++  L Q+ +    E +R E +Y       E L +   +  Y +++ E +  ++ 
Sbjct: 334 ECIKLKVDLLEQTKQGKRAERQRNEALY-----NAEELSKAFQQ--YKKKVAEKLEKVQA 386

Query: 507 QKEEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYKYLAALHEN 566
           ++E + + L++ ++  K +    G       +  E + +  ++++  ++  + +A   +N
Sbjct: 387 EEEILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAV--KN 444

Query: 567 CSQLIQTIEDTGTIMREVRDLEEQIETELGKKTLSN 602
              + Q  E   +I++   +LE + E    K +L N
Sbjct: 445 SEVMAQLTESRQSILKLESELENKDEILRDKFSLMN 480



 Score = 35.4 bits (80), Expect = 0.16
 Identities = 48/246 (19%), Positives = 96/246 (39%), Gaps = 29/246 (11%)

Query: 321  RPEQVTWAAQEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHSKLSTAERE 380
            R ++      EQE+  L++++E   + ++E+E+ MK       + E           +  
Sbjct: 1200 REKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMK-------EQEQYIATQYKEAIDLG 1252

Query: 381  QALRLKSRAVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQD 440
            Q LRL    V+      A     Q+  +   +R              L +E   +++L  
Sbjct: 1253 QELRLTREQVQNSHTELAEARHQQVQAQREIER--------------LSSELEDMKQLSK 1298

Query: 441  CRELESSRRLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRLAYTQRILEI 500
             ++   +    E+      VR A  EAR + E+ K+L +E+E+L     + AY   ++  
Sbjct: 1299 EKDAHGNHLAEELGA--SKVREAHLEARMQAEI-KKLSAEVESL-----KEAYHMEMISH 1350

Query: 501  VGNIRKQKEEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYKYL 560
              N  K K       S  ++L +++     +L+        L  +   +++ +  A + L
Sbjct: 1351 QENHAKWKISADSQKSSVQQLNEQLEKAKLELEEAQDTVSNLHQQVQDRNEVIEAANEAL 1410

Query: 561  AALHEN 566
                EN
Sbjct: 1411 LTKGEN 1416



 Score = 32.0 bits (71), Expect = 1.8
 Identities = 57/237 (24%), Positives = 94/237 (39%), Gaps = 47/237 (19%)

Query: 363 VQAESECRHSKLSTAEREQALRLKSRAVELLPDGTANLAKLQLVVENSAQRVIHLAGQWE 422
           VQAE E     L+  E+E   RL+ R           L K +L +     R +       
Sbjct: 384 VQAEEEILERNLTNCEKENK-RLQERC---------GLYKSELEILKEKLRQLKEENNNG 433

Query: 423 KHRVPLLAEYRHLRKLQDCRELESSRRLAEIQELHQSVRAAAEEARRKEEVYK---QLMS 479
           K ++ ++A             +++S  +A++ E  QS+     E   K+E+ +    LM+
Sbjct: 434 KEKLRIMA-------------VKNSEVMAQLTESRQSILKLESELENKDEILRDKFSLMN 480

Query: 480 ELETLPRDVS----RLAYTQRILEIVGNIRKQKEEITKILSDTKEL--------QKEINS 527
           E   L   V+    RL   Q+ +E      +  E+I   L   +EL        + +++S
Sbjct: 481 ENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSS 540

Query: 528 LSGKLDRTFA-------VTDELVFKDAKKDDAVRKAYKYLAALHENCSQLIQTIEDT 577
            S K DR          V  EL  K A K+  ++K +  L A     SQ + T  D+
Sbjct: 541 FSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTA--NQLSQSLITCNDS 595


>gi|45446749 kinesin family member 5A [Homo sapiens]
          Length = 1032

 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 64/314 (20%), Positives = 128/314 (40%), Gaps = 37/314 (11%)

Query: 330 QEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHSKLSTAEREQALRLKSRA 389
           QE+ L S R   E V R +  ++++         +         ++  ++ Q +  KS+ 
Sbjct: 452 QEELLVSTRGDNEKVQRELSHLQSENDAAKDEVKEVLQALEELAVNYDQKSQEVEEKSQQ 511

Query: 390 VELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLL----------------AEYR 433
            +LL D  +      L +E+  QR+  ++G   K    +L                 E +
Sbjct: 512 NQLLVDELSQKVATMLSLESELQRLQEVSGHQRKRIAEVLNGLMKDLSEFSVIVGNGEIK 571

Query: 434 HLRKLQDCRELESSRRLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRLAY 493
              ++    E E +     I ++   V++  +  R+ E +  +   ++E   R++S    
Sbjct: 572 LPVEISGAIEEEFTVARLYISKIKSEVKSVVKRCRQLENLQVECHRKMEVTGRELSSCQL 631

Query: 494 TQRILEIVGNIRKQKEEITKILSDTKELQKEINSLSGKLDRTFA--VTDELVFKDAKKD- 550
              I +    IR   E +  +    + L++  +SLS +L +  A     E+  KD + D 
Sbjct: 632 L--ISQHEAKIRSLTEYMQSVELKKRHLEESYDSLSDELAKLQAQETVHEVALKDKEPDT 689

Query: 551 ---DAVRKAYK-----YLAALHENCSQLIQTIEDTGTIMREVRDLEEQIETELGKKTLSN 602
              D V+KA +     +  A H   ++L   I +    + E++DL ++++ EL       
Sbjct: 690 QDADEVKKALELQMESHREAHHRQLARLRDEINEKQKTIDELKDLNQKLQLEL------- 742

Query: 603 LEKIREDYRALRQE 616
            EK++ DY  L+ E
Sbjct: 743 -EKLQADYEKLKSE 755



 Score = 38.9 bits (89), Expect = 0.014
 Identities = 57/271 (21%), Positives = 112/271 (41%), Gaps = 33/271 (12%)

Query: 366 ESECRHSKLSTAEREQALRLKSRAVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHR 425
           E E R       +++  +  +S+ +E          KL+  + +  + ++   G  EK  
Sbjct: 418 EEEIRRLYKQLDDKDDEINQQSQLIE----------KLKQQMLDQEELLVSTRGDNEK-- 465

Query: 426 VPLLAEYRHLRKLQDCRELESSRRLAEIQELHQSVRAAAEEARRKEEVYKQLMSEL-ETL 484
             +  E  HL+   D  + E    L  ++EL  +    ++E   K +  + L+ EL + +
Sbjct: 466 --VQRELSHLQSENDAAKDEVKEVLQALEELAVNYDQKSQEVEEKSQQNQLLVDELSQKV 523

Query: 485 PRDVSRLAYTQRILEIVGNIRKQKEEITK-ILSDTKELQKEINS--------LSGKLDRT 535
              +S  +  QR+ E+ G+ RK+  E+   ++ D  E    + +        +SG ++  
Sbjct: 524 ATMLSLESELQRLQEVSGHQRKRIAEVLNGLMKDLSEFSVIVGNGEIKLPVEISGAIEEE 583

Query: 536 FAVTDELVFKDAKKDDAVRKAYKYLAALHENCSQLIQTIEDTGTIMREVRDLEEQIETEL 595
           F V    + K   +  +V K  + L  L   C    + +E TG  +   + L  Q E ++
Sbjct: 584 FTVARLYISKIKSEVKSVVKRCRQLENLQVECH---RKMEVTGRELSSCQLLISQHEAKI 640

Query: 596 GKKT--LSNLE----KIREDYRALRQENAGL 620
              T  + ++E     + E Y +L  E A L
Sbjct: 641 RSLTEYMQSVELKKRHLEESYDSLSDELAKL 671


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 102/434 (23%), Positives = 171/434 (39%), Gaps = 67/434 (15%)

Query: 238  QEDTRAQRQRLQKQLTEHLRQSWGLLGAPIQARDLGELLQAWGAGAKTGAPKGSRFTHSE 297
            Q +  A + R Q +  E L+QS     A  QA+   +   A     K    + +R   +E
Sbjct: 2099 QAEREAAQSRRQVEEAERLKQS-----AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2153

Query: 298  KFTFHLEPQAQATQVSD---VPATSRRPEQVTWAAQEQELESLREQLEGVN--------- 345
            +     +  A A           T R+  QV     EQEL +LR QLE  +         
Sbjct: 2154 QAALRQKQAADAEMEKHKKFAEQTLRQKAQV-----EQELTTLRLQLEETDHQKNLLDEE 2208

Query: 346  ------------RSIEEVEADMKTLGV-----SFVQAESECRHSKLSTAEREQALRLKSR 388
                        R   +VE ++ ++ V     S ++A  E  +  L   +++   R    
Sbjct: 2209 LQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE 2268

Query: 389  AVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQDCRELESSR 448
              E +       A+L +  + +A R+  LA + +  +   LAE     K+Q  +  E++R
Sbjct: 2269 EAEKMKQVAEEAARLSVAAQEAA-RLRQLAEE-DLAQQRALAEKMLKEKMQAVQ--EATR 2324

Query: 449  RLAEIQELHQSVRAAAEEARR----KEEVYKQLMSELETLPRDVSRLAYTQRILEIVGNI 504
              AE + L Q    A E+ARR    KE++ +QL  E +   R +   A  QR LE+    
Sbjct: 2325 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLE--AERQRQLEMSAEA 2382

Query: 505  RKQKEEITKIL-------SDTKELQKEINSLSGKLDRTFAVTDELVF--------KDAKK 549
             + K  + ++         D +  +K+   +  KL RT   T E V         +    
Sbjct: 2383 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2442

Query: 550  DDA--VRKAYKYLAALHENCSQLIQTIEDTGTIMREVRDLEEQIETE-LGKKTLSNLEKI 606
             DA  +R+A   L    E   Q  + ++     M+ V+  +   ET+ L +  LS  + +
Sbjct: 2443 HDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2502

Query: 607  REDYRALRQENAGL 620
             +  R + QE A L
Sbjct: 2503 LQRERFIEQEKAKL 2516



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 72/320 (22%), Positives = 133/320 (41%), Gaps = 36/320 (11%)

Query: 320  RRPEQVTWAAQEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRH--SKLSTA 377
            RR EQ+  A    + +++REQL      +EE+E   + +         EC+    +   A
Sbjct: 1228 RRQEQIQ-AMPLADSQAVREQLRQEQALLEEIERHGEKV--------EECQRFAKQYINA 1278

Query: 378  EREQALRLKSRAVELLPDGT-ANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEY---- 432
             ++  L+L +   +L P  + A   K+Q   E+  Q  + L   + +    L ++Y    
Sbjct: 1279 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE-LTTLTSQYIKFI 1337

Query: 433  -RHLRKLQDCRELESSRRLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRL 491
               LR++++   L   +R AE +E    V AA E+ R+  E + Q  ++ E   +++ + 
Sbjct: 1338 SETLRRMEEEERLAEQQR-AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR 1396

Query: 492  AYTQ--RILEIVGNIRKQKEEITKIL-----SDTKELQKEINSLSGKLDRTFAVTDE--- 541
               +  R  E   + ++QK  I + L     S   E+Q +             + +E   
Sbjct: 1397 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1456

Query: 542  ----LVFKDAKKDDAVRKAYKYLAALHENCSQLIQTIEDTGTIMREVRD---LEEQIETE 594
                L   + ++  A  +     A   E  +Q  Q  E+   + R+V+D    + Q E E
Sbjct: 1457 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1516

Query: 595  LGKKTLSNLEKIREDYRALR 614
            L  +  +  E  RE  RAL+
Sbjct: 1517 LASRVKAEAEAAREKQRALQ 1536



 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 89/389 (22%), Positives = 157/389 (40%), Gaps = 45/389 (11%)

Query: 239  EDTRAQRQRLQKQLTEHLRQSWGLLGAPIQARDLGELLQAWGAGAKTGAPKGSRFTHSEK 298
            ED   QR+RL++Q  +H         A I+ R L +L +A  + ++    KG     + +
Sbjct: 1871 EDEAFQRRRLEEQAAQH--------KADIEER-LAQLRKA--SDSELERQKG-LVEDTLR 1918

Query: 299  FTFHLEPQAQATQVSDVPATSRRPEQVTWAAQEQELESLREQLEGVNRSIEEVE---ADM 355
                +E +  A + S   A + + E       E EL  +R   E   RS E+ E   A  
Sbjct: 1919 QRRQVEEEILALKASFEKAAAGKAE------LELELGRIRSNAEDTLRSKEQAELEAARQ 1972

Query: 356  KTLGVSFV--QAESECRHSKLSTAEREQALRLKS--RAVELLPDGTANLAKLQLVVENSA 411
            + L       + E+E R  K   AE E A + K+    VE L        +L+   E  +
Sbjct: 1973 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2032

Query: 412  QRVIHLAGQWEKHRVPLLAEYRHLRKLQDCRELESSRRLAEIQELHQSVRAAAEEARRKE 471
             R + LA +  + R+    E  H   +Q  +E E  + L + Q +   +R  AE ARR  
Sbjct: 2033 ARQLQLAQEAAQKRLQ-AEEKAHAFAVQQ-KEQELQQTLQQEQSVLDQLRGEAEAARRAA 2090

Query: 472  EVYKQLMSELETLPRDVSRLAYTQRILEIVGNIRKQKEEITKILSDTKELQKEINSLSGK 531
            E  ++   + E         A ++R +E    +++  EE  +  +  +   +++   + +
Sbjct: 2091 EEAEEARVQAE------REAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2144

Query: 532  LDRTFAVTDELVFKDAKKDDAVRKAYKYLAALHENCSQLIQTIEDTGTIMREVRDLEEQI 591
                 A  ++   +  +  DA  + +K  A          QT+     + +E+  L  Q+
Sbjct: 2145 EAARRAQAEQAALRQKQAADAEMEKHKKFAE---------QTLRQKAQVEQELTTLRLQL 2195

Query: 592  ETELGKKTLSNLEKIR---EDYRALRQEN 617
            E    +K L + E  R   E   A RQ +
Sbjct: 2196 EETDHQKNLLDEELQRLKAEATEAARQRS 2224



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 59/279 (21%), Positives = 118/279 (42%), Gaps = 42/279 (15%)

Query: 330  QEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHSKLSTAE---REQALRLK 386
            +EQ  + L E+ +G  R++E      + L +S      + R +++S A+    E A R +
Sbjct: 2350 KEQMAQQLAEETQGFQRTLEAER--QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR 2407

Query: 387  SRAVE----LLPDGTANLAKLQLVV---------ENSAQRVIHLAGQWEKHRVPLLAEYR 433
             +A E    L     A   K+ LV          ++ A+R+     + E+ +  L  E +
Sbjct: 2408 KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2467

Query: 434  HLR-KLQDCRELESSRRLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRLA 492
             L+ K ++ + ++  + L E Q L QS  +  +   ++E   +Q  ++LE L +D     
Sbjct: 2468 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD----- 2522

Query: 493  YTQRILEIVGNIRKQKEEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDA 552
                             E+ K     +E Q++   +  +  R  A  +E   +  + ++ 
Sbjct: 2523 -----------------EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2565

Query: 553  VRKAYKYLAALHENCSQLIQTIEDTGTIMRE-VRDLEEQ 590
            VR+  + L  L +   Q  + + +    +RE ++ LEEQ
Sbjct: 2566 VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2604



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 52/222 (23%), Positives = 91/222 (40%), Gaps = 34/222 (15%)

Query: 381  QALRLKSRAVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQD 440
            +A RLK+ A   L +  A   +L+ + E+ A +   L  Q  +H+  +      LRK  D
Sbjct: 1844 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1903

Query: 441  CRELESSRRLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRLAYTQRILEI 500
              ELE  + L E            +  R++ +V +++++    L     + A  +  LE+
Sbjct: 1904 -SELERQKGLVE------------DTLRQRRQVEEEILA----LKASFEKAAAGKAELEL 1946

Query: 501  -VGNIRKQKEEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYKY 559
             +G IR   E+  +         KE   L     R  A  +E      ++ +A  +  K 
Sbjct: 1947 ELGRIRSNAEDTLR--------SKEQAELEAARQRQLAAEEE-----RRRREAEERVQKS 1993

Query: 560  LAALHENCSQ---LIQTIEDTGTIMREVRDLEEQIETELGKK 598
            LAA  E   Q    ++ +E     + E R L E+ E E  ++
Sbjct: 1994 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2035



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 66/291 (22%), Positives = 131/291 (45%), Gaps = 30/291 (10%)

Query: 329  AQEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHSKLSTAEREQAL-RLKS 387
            A + ELE  +  +E   R   +VE ++  L  SF +A +         AE E  L R++S
Sbjct: 1901 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA-------GKAELELELGRIRS 1953

Query: 388  RAVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQDCRELESS 447
             A + L       +K Q  +E + QR   LA + E+ R    AE R ++K     E  + 
Sbjct: 1954 NAEDTL------RSKEQAELEAARQR--QLAAEEERRRRE--AEER-VQKSLAAEEEAAR 2002

Query: 448  RRLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRLAYTQRILEIVGNIRKQ 507
            +R A ++E+ + ++A  EEARR  E  +Q  +    L ++ ++             ++++
Sbjct: 2003 QRKAALEEV-ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2061

Query: 508  KEEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYKYLAALHENC 567
            ++E+ + L   ++ Q  ++ L G+ +      +E    +  +  A R+A +    + E  
Sbjct: 2062 EQELQQTL---QQEQSVLDQLRGEAEAARRAAEE---AEEARVQAEREAAQSRRQV-EEA 2114

Query: 568  SQLIQTIEDTGTIMREVRDLEEQIETELGKKTLSNLEKIREDYRALRQENA 618
             +L Q+ E+      + +   E++  E  ++      + + +  ALRQ+ A
Sbjct: 2115 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA---ARRAQAEQAALRQKQA 2162



 Score = 39.3 bits (90), Expect = 0.011
 Identities = 64/286 (22%), Positives = 119/286 (41%), Gaps = 47/286 (16%)

Query: 331  EQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECR--HSKLSTAEREQALRLKSR 388
            EQELE  R+  EG  +     E ++  L     Q E + +    +L+  +RE A   + R
Sbjct: 1691 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1750

Query: 389  AVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQDCRELESSR 448
              EL  +     A++++++ + A+         EK +  L AE    R+L +    E++R
Sbjct: 1751 Q-ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE----EAAR 1805

Query: 449  RLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRLAYTQRILEIVGNIRKQK 508
                       +RA AEEA+R+    +QL  E     R  +     +++  I        
Sbjct: 1806 -----------LRALAEEAKRQ----RQLAEEDAARQRAEAERVLAEKLAAI-------- 1842

Query: 509  EEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYKYLAALHENCS 568
             E T++ ++ +   KE  + + +L R              +D+A ++       L E  +
Sbjct: 1843 GEATRLKTEAEIALKEKEAENERLRR------------LAEDEAFQR-----RRLEEQAA 1885

Query: 569  QLIQTIEDTGTIMREVRDLEEQIETELGKKTLSNLEKIREDYRALR 614
            Q    IE+    +R+  D E + +  L + TL    ++ E+  AL+
Sbjct: 1886 QHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1931



 Score = 37.0 bits (84), Expect = 0.055
 Identities = 79/407 (19%), Positives = 164/407 (40%), Gaps = 35/407 (8%)

Query: 230  HRTSRLPPQEDTRAQRQRLQKQLTEHLRQSWGLLGAPIQARDLGELLQAWGAGAKTGAPK 289
            H  ++   + + +  +QR+Q+++   +R+    + A  Q R + E LQ     ++     
Sbjct: 1379 HAQAKAQAEREAKELQQRMQEEV---VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA 1435

Query: 290  GSRFTHS-EKFTFHLEPQAQATQVSDVPATSRRPEQVTWAAQEQELESLREQLEGVNRSI 348
             +R   + E+    +E + +  ++  + AT R+         E EL++LR + E      
Sbjct: 1436 KARQAEAAERSRLRIEEEIRVVRLQ-LEATERQR-----GGAEGELQALRARAEEAEAQK 1489

Query: 349  EEVEADMKTLGVSFVQAESECRHSKLSTAER----EQALRLKSRAVELLPDGTANLAKLQ 404
             + + + + L           R +++  A R     +A R K RA++ L +       L+
Sbjct: 1490 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE-------LR 1542

Query: 405  LVVENSAQRVIHLAGQWEKH-RVPLLAEYRHLRKLQDCRELESSRRLAEI----QELHQS 459
            L  E + +R+     +  +  +V L    R        +    + + A++    QE H +
Sbjct: 1543 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1602

Query: 460  VRAAAEEARRKEEVYKQLMSELETLPRDVSRLAYTQRILEIVGNIRKQKEEITKILSDTK 519
            V    EEA R+ +   +     E   R++ R  +  +  E +  +R Q EE+ +  S  +
Sbjct: 1603 VAQLREEAERRAQQQAEAERAREEAERELER--WQLKANEAL-RLRLQAEEVAQQKSLAQ 1659

Query: 520  -ELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYKYLAALHENCSQLIQTIEDTG 578
             E +K+      +  R     ++ V +    +  + K  +    L E  +Q     E   
Sbjct: 1660 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ----LAEGTAQQRLAAEQEL 1715

Query: 579  TIMREVRDLEEQIETELGKKTLSNLEKIREDYRALRQENAGLLGRVR 625
              +R   +  EQ + +L ++ L+ L++        RQE    L +VR
Sbjct: 1716 IRLRAETEQGEQ-QRQLLEEELARLQREAAAATQKRQELEAELAKVR 1761



 Score = 30.8 bits (68), Expect = 3.9
 Identities = 63/277 (22%), Positives = 99/277 (35%), Gaps = 40/277 (14%)

Query: 229  VHRTSRLPPQEDTRAQRQRLQKQLTEH------------------LRQSWGLL---GAPI 267
            +HRT     ++ T  Q   +Q+Q ++H                  L+Q   LL      +
Sbjct: 2417 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2476

Query: 268  QARDLGELLQAWGA------GAKTGAPKGSRFTHSEKFTFHLEPQAQATQVSDVPATSRR 321
            Q     +LLQ   A        K    +  RF   EK       Q +  +   +    +R
Sbjct: 2477 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2536

Query: 322  PEQVTWAAQEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHSKLSTAEREQ 381
             +Q      EQE + L   +E   R   E E  ++       Q E + R  +   AE  Q
Sbjct: 2537 QQQ----QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ 2592

Query: 382  ALRLKSRAVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLL-AEYRH----LR 436
             LR + + +E      A LA  + V  +       L    +    P   AE  H    LR
Sbjct: 2593 RLREQLQLLE--EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLR 2650

Query: 437  KLQDCRELESSRRLA--EIQELHQSVRAAAEEARRKE 471
            +    + L+ +  L+  E+Q L Q      E ARR++
Sbjct: 2651 RKVSAQRLQEAGILSAEELQRLAQGHTTVDELARRED 2687


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 102/434 (23%), Positives = 171/434 (39%), Gaps = 67/434 (15%)

Query: 238  QEDTRAQRQRLQKQLTEHLRQSWGLLGAPIQARDLGELLQAWGAGAKTGAPKGSRFTHSE 297
            Q +  A + R Q +  E L+QS     A  QA+   +   A     K    + +R   +E
Sbjct: 2103 QAEREAAQSRRQVEEAERLKQS-----AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2157

Query: 298  KFTFHLEPQAQATQVSD---VPATSRRPEQVTWAAQEQELESLREQLEGVN--------- 345
            +     +  A A           T R+  QV     EQEL +LR QLE  +         
Sbjct: 2158 QAALRQKQAADAEMEKHKKFAEQTLRQKAQV-----EQELTTLRLQLEETDHQKNLLDEE 2212

Query: 346  ------------RSIEEVEADMKTLGV-----SFVQAESECRHSKLSTAEREQALRLKSR 388
                        R   +VE ++ ++ V     S ++A  E  +  L   +++   R    
Sbjct: 2213 LQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE 2272

Query: 389  AVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQDCRELESSR 448
              E +       A+L +  + +A R+  LA + +  +   LAE     K+Q  +  E++R
Sbjct: 2273 EAEKMKQVAEEAARLSVAAQEAA-RLRQLAEE-DLAQQRALAEKMLKEKMQAVQ--EATR 2328

Query: 449  RLAEIQELHQSVRAAAEEARR----KEEVYKQLMSELETLPRDVSRLAYTQRILEIVGNI 504
              AE + L Q    A E+ARR    KE++ +QL  E +   R +   A  QR LE+    
Sbjct: 2329 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLE--AERQRQLEMSAEA 2386

Query: 505  RKQKEEITKIL-------SDTKELQKEINSLSGKLDRTFAVTDELVF--------KDAKK 549
             + K  + ++         D +  +K+   +  KL RT   T E V         +    
Sbjct: 2387 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2446

Query: 550  DDA--VRKAYKYLAALHENCSQLIQTIEDTGTIMREVRDLEEQIETE-LGKKTLSNLEKI 606
             DA  +R+A   L    E   Q  + ++     M+ V+  +   ET+ L +  LS  + +
Sbjct: 2447 HDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2506

Query: 607  REDYRALRQENAGL 620
             +  R + QE A L
Sbjct: 2507 LQRERFIEQEKAKL 2520



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 72/320 (22%), Positives = 133/320 (41%), Gaps = 36/320 (11%)

Query: 320  RRPEQVTWAAQEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRH--SKLSTA 377
            RR EQ+  A    + +++REQL      +EE+E   + +         EC+    +   A
Sbjct: 1232 RRQEQIQ-AMPLADSQAVREQLRQEQALLEEIERHGEKV--------EECQRFAKQYINA 1282

Query: 378  EREQALRLKSRAVELLPDGT-ANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEY---- 432
             ++  L+L +   +L P  + A   K+Q   E+  Q  + L   + +    L ++Y    
Sbjct: 1283 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE-LTTLTSQYIKFI 1341

Query: 433  -RHLRKLQDCRELESSRRLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRL 491
               LR++++   L   +R AE +E    V AA E+ R+  E + Q  ++ E   +++ + 
Sbjct: 1342 SETLRRMEEEERLAEQQR-AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR 1400

Query: 492  AYTQ--RILEIVGNIRKQKEEITKIL-----SDTKELQKEINSLSGKLDRTFAVTDE--- 541
               +  R  E   + ++QK  I + L     S   E+Q +             + +E   
Sbjct: 1401 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1460

Query: 542  ----LVFKDAKKDDAVRKAYKYLAALHENCSQLIQTIEDTGTIMREVRD---LEEQIETE 594
                L   + ++  A  +     A   E  +Q  Q  E+   + R+V+D    + Q E E
Sbjct: 1461 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1520

Query: 595  LGKKTLSNLEKIREDYRALR 614
            L  +  +  E  RE  RAL+
Sbjct: 1521 LASRVKAEAEAAREKQRALQ 1540



 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 89/389 (22%), Positives = 157/389 (40%), Gaps = 45/389 (11%)

Query: 239  EDTRAQRQRLQKQLTEHLRQSWGLLGAPIQARDLGELLQAWGAGAKTGAPKGSRFTHSEK 298
            ED   QR+RL++Q  +H         A I+ R L +L +A  + ++    KG     + +
Sbjct: 1875 EDEAFQRRRLEEQAAQH--------KADIEER-LAQLRKA--SDSELERQKG-LVEDTLR 1922

Query: 299  FTFHLEPQAQATQVSDVPATSRRPEQVTWAAQEQELESLREQLEGVNRSIEEVE---ADM 355
                +E +  A + S   A + + E       E EL  +R   E   RS E+ E   A  
Sbjct: 1923 QRRQVEEEILALKASFEKAAAGKAE------LELELGRIRSNAEDTLRSKEQAELEAARQ 1976

Query: 356  KTLGVSFV--QAESECRHSKLSTAEREQALRLKS--RAVELLPDGTANLAKLQLVVENSA 411
            + L       + E+E R  K   AE E A + K+    VE L        +L+   E  +
Sbjct: 1977 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2036

Query: 412  QRVIHLAGQWEKHRVPLLAEYRHLRKLQDCRELESSRRLAEIQELHQSVRAAAEEARRKE 471
             R + LA +  + R+    E  H   +Q  +E E  + L + Q +   +R  AE ARR  
Sbjct: 2037 ARQLQLAQEAAQKRLQ-AEEKAHAFAVQQ-KEQELQQTLQQEQSVLDQLRGEAEAARRAA 2094

Query: 472  EVYKQLMSELETLPRDVSRLAYTQRILEIVGNIRKQKEEITKILSDTKELQKEINSLSGK 531
            E  ++   + E         A ++R +E    +++  EE  +  +  +   +++   + +
Sbjct: 2095 EEAEEARVQAE------REAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2148

Query: 532  LDRTFAVTDELVFKDAKKDDAVRKAYKYLAALHENCSQLIQTIEDTGTIMREVRDLEEQI 591
                 A  ++   +  +  DA  + +K  A          QT+     + +E+  L  Q+
Sbjct: 2149 EAARRAQAEQAALRQKQAADAEMEKHKKFAE---------QTLRQKAQVEQELTTLRLQL 2199

Query: 592  ETELGKKTLSNLEKIR---EDYRALRQEN 617
            E    +K L + E  R   E   A RQ +
Sbjct: 2200 EETDHQKNLLDEELQRLKAEATEAARQRS 2228



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 59/279 (21%), Positives = 118/279 (42%), Gaps = 42/279 (15%)

Query: 330  QEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHSKLSTAE---REQALRLK 386
            +EQ  + L E+ +G  R++E      + L +S      + R +++S A+    E A R +
Sbjct: 2354 KEQMAQQLAEETQGFQRTLEAER--QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR 2411

Query: 387  SRAVE----LLPDGTANLAKLQLVV---------ENSAQRVIHLAGQWEKHRVPLLAEYR 433
             +A E    L     A   K+ LV          ++ A+R+     + E+ +  L  E +
Sbjct: 2412 KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2471

Query: 434  HLR-KLQDCRELESSRRLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRLA 492
             L+ K ++ + ++  + L E Q L QS  +  +   ++E   +Q  ++LE L +D     
Sbjct: 2472 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD----- 2526

Query: 493  YTQRILEIVGNIRKQKEEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDA 552
                             E+ K     +E Q++   +  +  R  A  +E   +  + ++ 
Sbjct: 2527 -----------------EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2569

Query: 553  VRKAYKYLAALHENCSQLIQTIEDTGTIMRE-VRDLEEQ 590
            VR+  + L  L +   Q  + + +    +RE ++ LEEQ
Sbjct: 2570 VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2608



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 52/222 (23%), Positives = 91/222 (40%), Gaps = 34/222 (15%)

Query: 381  QALRLKSRAVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQD 440
            +A RLK+ A   L +  A   +L+ + E+ A +   L  Q  +H+  +      LRK  D
Sbjct: 1848 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1907

Query: 441  CRELESSRRLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRLAYTQRILEI 500
              ELE  + L E            +  R++ +V +++++    L     + A  +  LE+
Sbjct: 1908 -SELERQKGLVE------------DTLRQRRQVEEEILA----LKASFEKAAAGKAELEL 1950

Query: 501  -VGNIRKQKEEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYKY 559
             +G IR   E+  +         KE   L     R  A  +E      ++ +A  +  K 
Sbjct: 1951 ELGRIRSNAEDTLR--------SKEQAELEAARQRQLAAEEE-----RRRREAEERVQKS 1997

Query: 560  LAALHENCSQ---LIQTIEDTGTIMREVRDLEEQIETELGKK 598
            LAA  E   Q    ++ +E     + E R L E+ E E  ++
Sbjct: 1998 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2039



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 66/291 (22%), Positives = 131/291 (45%), Gaps = 30/291 (10%)

Query: 329  AQEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHSKLSTAEREQAL-RLKS 387
            A + ELE  +  +E   R   +VE ++  L  SF +A +         AE E  L R++S
Sbjct: 1905 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA-------GKAELELELGRIRS 1957

Query: 388  RAVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQDCRELESS 447
             A + L       +K Q  +E + QR   LA + E+ R    AE R ++K     E  + 
Sbjct: 1958 NAEDTL------RSKEQAELEAARQR--QLAAEEERRRRE--AEER-VQKSLAAEEEAAR 2006

Query: 448  RRLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRLAYTQRILEIVGNIRKQ 507
            +R A ++E+ + ++A  EEARR  E  +Q  +    L ++ ++             ++++
Sbjct: 2007 QRKAALEEV-ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2065

Query: 508  KEEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYKYLAALHENC 567
            ++E+ + L   ++ Q  ++ L G+ +      +E    +  +  A R+A +    + E  
Sbjct: 2066 EQELQQTL---QQEQSVLDQLRGEAEAARRAAEE---AEEARVQAEREAAQSRRQV-EEA 2118

Query: 568  SQLIQTIEDTGTIMREVRDLEEQIETELGKKTLSNLEKIREDYRALRQENA 618
             +L Q+ E+      + +   E++  E  ++      + + +  ALRQ+ A
Sbjct: 2119 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA---ARRAQAEQAALRQKQA 2166



 Score = 39.3 bits (90), Expect = 0.011
 Identities = 64/286 (22%), Positives = 119/286 (41%), Gaps = 47/286 (16%)

Query: 331  EQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECR--HSKLSTAEREQALRLKSR 388
            EQELE  R+  EG  +     E ++  L     Q E + +    +L+  +RE A   + R
Sbjct: 1695 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1754

Query: 389  AVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQDCRELESSR 448
              EL  +     A++++++ + A+         EK +  L AE    R+L +    E++R
Sbjct: 1755 Q-ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE----EAAR 1809

Query: 449  RLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRLAYTQRILEIVGNIRKQK 508
                       +RA AEEA+R+    +QL  E     R  +     +++  I        
Sbjct: 1810 -----------LRALAEEAKRQ----RQLAEEDAARQRAEAERVLAEKLAAI-------- 1846

Query: 509  EEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYKYLAALHENCS 568
             E T++ ++ +   KE  + + +L R              +D+A ++       L E  +
Sbjct: 1847 GEATRLKTEAEIALKEKEAENERLRR------------LAEDEAFQR-----RRLEEQAA 1889

Query: 569  QLIQTIEDTGTIMREVRDLEEQIETELGKKTLSNLEKIREDYRALR 614
            Q    IE+    +R+  D E + +  L + TL    ++ E+  AL+
Sbjct: 1890 QHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1935



 Score = 37.0 bits (84), Expect = 0.055
 Identities = 79/407 (19%), Positives = 164/407 (40%), Gaps = 35/407 (8%)

Query: 230  HRTSRLPPQEDTRAQRQRLQKQLTEHLRQSWGLLGAPIQARDLGELLQAWGAGAKTGAPK 289
            H  ++   + + +  +QR+Q+++   +R+    + A  Q R + E LQ     ++     
Sbjct: 1383 HAQAKAQAEREAKELQQRMQEEV---VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA 1439

Query: 290  GSRFTHS-EKFTFHLEPQAQATQVSDVPATSRRPEQVTWAAQEQELESLREQLEGVNRSI 348
             +R   + E+    +E + +  ++  + AT R+         E EL++LR + E      
Sbjct: 1440 KARQAEAAERSRLRIEEEIRVVRLQ-LEATERQR-----GGAEGELQALRARAEEAEAQK 1493

Query: 349  EEVEADMKTLGVSFVQAESECRHSKLSTAER----EQALRLKSRAVELLPDGTANLAKLQ 404
             + + + + L           R +++  A R     +A R K RA++ L +       L+
Sbjct: 1494 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE-------LR 1546

Query: 405  LVVENSAQRVIHLAGQWEKH-RVPLLAEYRHLRKLQDCRELESSRRLAEI----QELHQS 459
            L  E + +R+     +  +  +V L    R        +    + + A++    QE H +
Sbjct: 1547 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1606

Query: 460  VRAAAEEARRKEEVYKQLMSELETLPRDVSRLAYTQRILEIVGNIRKQKEEITKILSDTK 519
            V    EEA R+ +   +     E   R++ R  +  +  E +  +R Q EE+ +  S  +
Sbjct: 1607 VAQLREEAERRAQQQAEAERAREEAERELER--WQLKANEAL-RLRLQAEEVAQQKSLAQ 1663

Query: 520  -ELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYKYLAALHENCSQLIQTIEDTG 578
             E +K+      +  R     ++ V +    +  + K  +    L E  +Q     E   
Sbjct: 1664 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ----LAEGTAQQRLAAEQEL 1719

Query: 579  TIMREVRDLEEQIETELGKKTLSNLEKIREDYRALRQENAGLLGRVR 625
              +R   +  EQ + +L ++ L+ L++        RQE    L +VR
Sbjct: 1720 IRLRAETEQGEQ-QRQLLEEELARLQREAAAATQKRQELEAELAKVR 1765



 Score = 30.8 bits (68), Expect = 3.9
 Identities = 63/277 (22%), Positives = 99/277 (35%), Gaps = 40/277 (14%)

Query: 229  VHRTSRLPPQEDTRAQRQRLQKQLTEH------------------LRQSWGLL---GAPI 267
            +HRT     ++ T  Q   +Q+Q ++H                  L+Q   LL      +
Sbjct: 2421 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2480

Query: 268  QARDLGELLQAWGA------GAKTGAPKGSRFTHSEKFTFHLEPQAQATQVSDVPATSRR 321
            Q     +LLQ   A        K    +  RF   EK       Q +  +   +    +R
Sbjct: 2481 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2540

Query: 322  PEQVTWAAQEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHSKLSTAEREQ 381
             +Q      EQE + L   +E   R   E E  ++       Q E + R  +   AE  Q
Sbjct: 2541 QQQ----QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ 2596

Query: 382  ALRLKSRAVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLL-AEYRH----LR 436
             LR + + +E      A LA  + V  +       L    +    P   AE  H    LR
Sbjct: 2597 RLREQLQLLE--EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLR 2654

Query: 437  KLQDCRELESSRRLA--EIQELHQSVRAAAEEARRKE 471
            +    + L+ +  L+  E+Q L Q      E ARR++
Sbjct: 2655 RKVSAQRLQEAGILSAEELQRLAQGHTTVDELARRED 2691


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 102/434 (23%), Positives = 171/434 (39%), Gaps = 67/434 (15%)

Query: 238  QEDTRAQRQRLQKQLTEHLRQSWGLLGAPIQARDLGELLQAWGAGAKTGAPKGSRFTHSE 297
            Q +  A + R Q +  E L+QS     A  QA+   +   A     K    + +R   +E
Sbjct: 2099 QAEREAAQSRRQVEEAERLKQS-----AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2153

Query: 298  KFTFHLEPQAQATQVSD---VPATSRRPEQVTWAAQEQELESLREQLEGVN--------- 345
            +     +  A A           T R+  QV     EQEL +LR QLE  +         
Sbjct: 2154 QAALRQKQAADAEMEKHKKFAEQTLRQKAQV-----EQELTTLRLQLEETDHQKNLLDEE 2208

Query: 346  ------------RSIEEVEADMKTLGV-----SFVQAESECRHSKLSTAEREQALRLKSR 388
                        R   +VE ++ ++ V     S ++A  E  +  L   +++   R    
Sbjct: 2209 LQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE 2268

Query: 389  AVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQDCRELESSR 448
              E +       A+L +  + +A R+  LA + +  +   LAE     K+Q  +  E++R
Sbjct: 2269 EAEKMKQVAEEAARLSVAAQEAA-RLRQLAEE-DLAQQRALAEKMLKEKMQAVQ--EATR 2324

Query: 449  RLAEIQELHQSVRAAAEEARR----KEEVYKQLMSELETLPRDVSRLAYTQRILEIVGNI 504
              AE + L Q    A E+ARR    KE++ +QL  E +   R +   A  QR LE+    
Sbjct: 2325 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLE--AERQRQLEMSAEA 2382

Query: 505  RKQKEEITKIL-------SDTKELQKEINSLSGKLDRTFAVTDELVF--------KDAKK 549
             + K  + ++         D +  +K+   +  KL RT   T E V         +    
Sbjct: 2383 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2442

Query: 550  DDA--VRKAYKYLAALHENCSQLIQTIEDTGTIMREVRDLEEQIETE-LGKKTLSNLEKI 606
             DA  +R+A   L    E   Q  + ++     M+ V+  +   ET+ L +  LS  + +
Sbjct: 2443 HDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2502

Query: 607  REDYRALRQENAGL 620
             +  R + QE A L
Sbjct: 2503 LQRERFIEQEKAKL 2516



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 72/320 (22%), Positives = 133/320 (41%), Gaps = 36/320 (11%)

Query: 320  RRPEQVTWAAQEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRH--SKLSTA 377
            RR EQ+  A    + +++REQL      +EE+E   + +         EC+    +   A
Sbjct: 1228 RRQEQIQ-AMPLADSQAVREQLRQEQALLEEIERHGEKV--------EECQRFAKQYINA 1278

Query: 378  EREQALRLKSRAVELLPDGT-ANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEY---- 432
             ++  L+L +   +L P  + A   K+Q   E+  Q  + L   + +    L ++Y    
Sbjct: 1279 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE-LTTLTSQYIKFI 1337

Query: 433  -RHLRKLQDCRELESSRRLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRL 491
               LR++++   L   +R AE +E    V AA E+ R+  E + Q  ++ E   +++ + 
Sbjct: 1338 SETLRRMEEEERLAEQQR-AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR 1396

Query: 492  AYTQ--RILEIVGNIRKQKEEITKIL-----SDTKELQKEINSLSGKLDRTFAVTDE--- 541
               +  R  E   + ++QK  I + L     S   E+Q +             + +E   
Sbjct: 1397 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1456

Query: 542  ----LVFKDAKKDDAVRKAYKYLAALHENCSQLIQTIEDTGTIMREVRD---LEEQIETE 594
                L   + ++  A  +     A   E  +Q  Q  E+   + R+V+D    + Q E E
Sbjct: 1457 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1516

Query: 595  LGKKTLSNLEKIREDYRALR 614
            L  +  +  E  RE  RAL+
Sbjct: 1517 LASRVKAEAEAAREKQRALQ 1536



 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 89/389 (22%), Positives = 157/389 (40%), Gaps = 45/389 (11%)

Query: 239  EDTRAQRQRLQKQLTEHLRQSWGLLGAPIQARDLGELLQAWGAGAKTGAPKGSRFTHSEK 298
            ED   QR+RL++Q  +H         A I+ R L +L +A  + ++    KG     + +
Sbjct: 1871 EDEAFQRRRLEEQAAQH--------KADIEER-LAQLRKA--SDSELERQKG-LVEDTLR 1918

Query: 299  FTFHLEPQAQATQVSDVPATSRRPEQVTWAAQEQELESLREQLEGVNRSIEEVE---ADM 355
                +E +  A + S   A + + E       E EL  +R   E   RS E+ E   A  
Sbjct: 1919 QRRQVEEEILALKASFEKAAAGKAE------LELELGRIRSNAEDTLRSKEQAELEAARQ 1972

Query: 356  KTLGVSFV--QAESECRHSKLSTAEREQALRLKS--RAVELLPDGTANLAKLQLVVENSA 411
            + L       + E+E R  K   AE E A + K+    VE L        +L+   E  +
Sbjct: 1973 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2032

Query: 412  QRVIHLAGQWEKHRVPLLAEYRHLRKLQDCRELESSRRLAEIQELHQSVRAAAEEARRKE 471
             R + LA +  + R+    E  H   +Q  +E E  + L + Q +   +R  AE ARR  
Sbjct: 2033 ARQLQLAQEAAQKRLQ-AEEKAHAFAVQQ-KEQELQQTLQQEQSVLDQLRGEAEAARRAA 2090

Query: 472  EVYKQLMSELETLPRDVSRLAYTQRILEIVGNIRKQKEEITKILSDTKELQKEINSLSGK 531
            E  ++   + E         A ++R +E    +++  EE  +  +  +   +++   + +
Sbjct: 2091 EEAEEARVQAE------REAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2144

Query: 532  LDRTFAVTDELVFKDAKKDDAVRKAYKYLAALHENCSQLIQTIEDTGTIMREVRDLEEQI 591
                 A  ++   +  +  DA  + +K  A          QT+     + +E+  L  Q+
Sbjct: 2145 EAARRAQAEQAALRQKQAADAEMEKHKKFAE---------QTLRQKAQVEQELTTLRLQL 2195

Query: 592  ETELGKKTLSNLEKIR---EDYRALRQEN 617
            E    +K L + E  R   E   A RQ +
Sbjct: 2196 EETDHQKNLLDEELQRLKAEATEAARQRS 2224



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 59/279 (21%), Positives = 118/279 (42%), Gaps = 42/279 (15%)

Query: 330  QEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHSKLSTAE---REQALRLK 386
            +EQ  + L E+ +G  R++E      + L +S      + R +++S A+    E A R +
Sbjct: 2350 KEQMAQQLAEETQGFQRTLEAER--QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR 2407

Query: 387  SRAVE----LLPDGTANLAKLQLVV---------ENSAQRVIHLAGQWEKHRVPLLAEYR 433
             +A E    L     A   K+ LV          ++ A+R+     + E+ +  L  E +
Sbjct: 2408 KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2467

Query: 434  HLR-KLQDCRELESSRRLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRLA 492
             L+ K ++ + ++  + L E Q L QS  +  +   ++E   +Q  ++LE L +D     
Sbjct: 2468 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD----- 2522

Query: 493  YTQRILEIVGNIRKQKEEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDA 552
                             E+ K     +E Q++   +  +  R  A  +E   +  + ++ 
Sbjct: 2523 -----------------EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2565

Query: 553  VRKAYKYLAALHENCSQLIQTIEDTGTIMRE-VRDLEEQ 590
            VR+  + L  L +   Q  + + +    +RE ++ LEEQ
Sbjct: 2566 VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2604



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 52/222 (23%), Positives = 91/222 (40%), Gaps = 34/222 (15%)

Query: 381  QALRLKSRAVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQD 440
            +A RLK+ A   L +  A   +L+ + E+ A +   L  Q  +H+  +      LRK  D
Sbjct: 1844 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1903

Query: 441  CRELESSRRLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRLAYTQRILEI 500
              ELE  + L E            +  R++ +V +++++    L     + A  +  LE+
Sbjct: 1904 -SELERQKGLVE------------DTLRQRRQVEEEILA----LKASFEKAAAGKAELEL 1946

Query: 501  -VGNIRKQKEEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYKY 559
             +G IR   E+  +         KE   L     R  A  +E      ++ +A  +  K 
Sbjct: 1947 ELGRIRSNAEDTLR--------SKEQAELEAARQRQLAAEEE-----RRRREAEERVQKS 1993

Query: 560  LAALHENCSQ---LIQTIEDTGTIMREVRDLEEQIETELGKK 598
            LAA  E   Q    ++ +E     + E R L E+ E E  ++
Sbjct: 1994 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2035



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 66/291 (22%), Positives = 131/291 (45%), Gaps = 30/291 (10%)

Query: 329  AQEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHSKLSTAEREQAL-RLKS 387
            A + ELE  +  +E   R   +VE ++  L  SF +A +         AE E  L R++S
Sbjct: 1901 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA-------GKAELELELGRIRS 1953

Query: 388  RAVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQDCRELESS 447
             A + L       +K Q  +E + QR   LA + E+ R    AE R ++K     E  + 
Sbjct: 1954 NAEDTL------RSKEQAELEAARQR--QLAAEEERRRRE--AEER-VQKSLAAEEEAAR 2002

Query: 448  RRLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRLAYTQRILEIVGNIRKQ 507
            +R A ++E+ + ++A  EEARR  E  +Q  +    L ++ ++             ++++
Sbjct: 2003 QRKAALEEV-ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2061

Query: 508  KEEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYKYLAALHENC 567
            ++E+ + L   ++ Q  ++ L G+ +      +E    +  +  A R+A +    + E  
Sbjct: 2062 EQELQQTL---QQEQSVLDQLRGEAEAARRAAEE---AEEARVQAEREAAQSRRQV-EEA 2114

Query: 568  SQLIQTIEDTGTIMREVRDLEEQIETELGKKTLSNLEKIREDYRALRQENA 618
             +L Q+ E+      + +   E++  E  ++      + + +  ALRQ+ A
Sbjct: 2115 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA---ARRAQAEQAALRQKQA 2162



 Score = 39.3 bits (90), Expect = 0.011
 Identities = 64/286 (22%), Positives = 119/286 (41%), Gaps = 47/286 (16%)

Query: 331  EQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECR--HSKLSTAEREQALRLKSR 388
            EQELE  R+  EG  +     E ++  L     Q E + +    +L+  +RE A   + R
Sbjct: 1691 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1750

Query: 389  AVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQDCRELESSR 448
              EL  +     A++++++ + A+         EK +  L AE    R+L +    E++R
Sbjct: 1751 Q-ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE----EAAR 1805

Query: 449  RLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRLAYTQRILEIVGNIRKQK 508
                       +RA AEEA+R+    +QL  E     R  +     +++  I        
Sbjct: 1806 -----------LRALAEEAKRQ----RQLAEEDAARQRAEAERVLAEKLAAI-------- 1842

Query: 509  EEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYKYLAALHENCS 568
             E T++ ++ +   KE  + + +L R              +D+A ++       L E  +
Sbjct: 1843 GEATRLKTEAEIALKEKEAENERLRR------------LAEDEAFQR-----RRLEEQAA 1885

Query: 569  QLIQTIEDTGTIMREVRDLEEQIETELGKKTLSNLEKIREDYRALR 614
            Q    IE+    +R+  D E + +  L + TL    ++ E+  AL+
Sbjct: 1886 QHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1931



 Score = 37.0 bits (84), Expect = 0.055
 Identities = 79/407 (19%), Positives = 164/407 (40%), Gaps = 35/407 (8%)

Query: 230  HRTSRLPPQEDTRAQRQRLQKQLTEHLRQSWGLLGAPIQARDLGELLQAWGAGAKTGAPK 289
            H  ++   + + +  +QR+Q+++   +R+    + A  Q R + E LQ     ++     
Sbjct: 1379 HAQAKAQAEREAKELQQRMQEEV---VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA 1435

Query: 290  GSRFTHS-EKFTFHLEPQAQATQVSDVPATSRRPEQVTWAAQEQELESLREQLEGVNRSI 348
             +R   + E+    +E + +  ++  + AT R+         E EL++LR + E      
Sbjct: 1436 KARQAEAAERSRLRIEEEIRVVRLQ-LEATERQR-----GGAEGELQALRARAEEAEAQK 1489

Query: 349  EEVEADMKTLGVSFVQAESECRHSKLSTAER----EQALRLKSRAVELLPDGTANLAKLQ 404
             + + + + L           R +++  A R     +A R K RA++ L +       L+
Sbjct: 1490 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE-------LR 1542

Query: 405  LVVENSAQRVIHLAGQWEKH-RVPLLAEYRHLRKLQDCRELESSRRLAEI----QELHQS 459
            L  E + +R+     +  +  +V L    R        +    + + A++    QE H +
Sbjct: 1543 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1602

Query: 460  VRAAAEEARRKEEVYKQLMSELETLPRDVSRLAYTQRILEIVGNIRKQKEEITKILSDTK 519
            V    EEA R+ +   +     E   R++ R  +  +  E +  +R Q EE+ +  S  +
Sbjct: 1603 VAQLREEAERRAQQQAEAERAREEAERELER--WQLKANEAL-RLRLQAEEVAQQKSLAQ 1659

Query: 520  -ELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYKYLAALHENCSQLIQTIEDTG 578
             E +K+      +  R     ++ V +    +  + K  +    L E  +Q     E   
Sbjct: 1660 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ----LAEGTAQQRLAAEQEL 1715

Query: 579  TIMREVRDLEEQIETELGKKTLSNLEKIREDYRALRQENAGLLGRVR 625
              +R   +  EQ + +L ++ L+ L++        RQE    L +VR
Sbjct: 1716 IRLRAETEQGEQ-QRQLLEEELARLQREAAAATQKRQELEAELAKVR 1761



 Score = 30.8 bits (68), Expect = 3.9
 Identities = 63/277 (22%), Positives = 99/277 (35%), Gaps = 40/277 (14%)

Query: 229  VHRTSRLPPQEDTRAQRQRLQKQLTEH------------------LRQSWGLL---GAPI 267
            +HRT     ++ T  Q   +Q+Q ++H                  L+Q   LL      +
Sbjct: 2417 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2476

Query: 268  QARDLGELLQAWGA------GAKTGAPKGSRFTHSEKFTFHLEPQAQATQVSDVPATSRR 321
            Q     +LLQ   A        K    +  RF   EK       Q +  +   +    +R
Sbjct: 2477 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2536

Query: 322  PEQVTWAAQEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHSKLSTAEREQ 381
             +Q      EQE + L   +E   R   E E  ++       Q E + R  +   AE  Q
Sbjct: 2537 QQQ----QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ 2592

Query: 382  ALRLKSRAVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLL-AEYRH----LR 436
             LR + + +E      A LA  + V  +       L    +    P   AE  H    LR
Sbjct: 2593 RLREQLQLLE--EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLR 2650

Query: 437  KLQDCRELESSRRLA--EIQELHQSVRAAAEEARRKE 471
            +    + L+ +  L+  E+Q L Q      E ARR++
Sbjct: 2651 RKVSAQRLQEAGILSAEELQRLAQGHTTVDELARRED 2687


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 102/434 (23%), Positives = 171/434 (39%), Gaps = 67/434 (15%)

Query: 238  QEDTRAQRQRLQKQLTEHLRQSWGLLGAPIQARDLGELLQAWGAGAKTGAPKGSRFTHSE 297
            Q +  A + R Q +  E L+QS     A  QA+   +   A     K    + +R   +E
Sbjct: 2067 QAEREAAQSRRQVEEAERLKQS-----AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2121

Query: 298  KFTFHLEPQAQATQVSD---VPATSRRPEQVTWAAQEQELESLREQLEGVN--------- 345
            +     +  A A           T R+  QV     EQEL +LR QLE  +         
Sbjct: 2122 QAALRQKQAADAEMEKHKKFAEQTLRQKAQV-----EQELTTLRLQLEETDHQKNLLDEE 2176

Query: 346  ------------RSIEEVEADMKTLGV-----SFVQAESECRHSKLSTAEREQALRLKSR 388
                        R   +VE ++ ++ V     S ++A  E  +  L   +++   R    
Sbjct: 2177 LQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE 2236

Query: 389  AVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQDCRELESSR 448
              E +       A+L +  + +A R+  LA + +  +   LAE     K+Q  +  E++R
Sbjct: 2237 EAEKMKQVAEEAARLSVAAQEAA-RLRQLAEE-DLAQQRALAEKMLKEKMQAVQ--EATR 2292

Query: 449  RLAEIQELHQSVRAAAEEARR----KEEVYKQLMSELETLPRDVSRLAYTQRILEIVGNI 504
              AE + L Q    A E+ARR    KE++ +QL  E +   R +   A  QR LE+    
Sbjct: 2293 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLE--AERQRQLEMSAEA 2350

Query: 505  RKQKEEITKIL-------SDTKELQKEINSLSGKLDRTFAVTDELVF--------KDAKK 549
             + K  + ++         D +  +K+   +  KL RT   T E V         +    
Sbjct: 2351 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2410

Query: 550  DDA--VRKAYKYLAALHENCSQLIQTIEDTGTIMREVRDLEEQIETE-LGKKTLSNLEKI 606
             DA  +R+A   L    E   Q  + ++     M+ V+  +   ET+ L +  LS  + +
Sbjct: 2411 HDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2470

Query: 607  REDYRALRQENAGL 620
             +  R + QE A L
Sbjct: 2471 LQRERFIEQEKAKL 2484



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 72/320 (22%), Positives = 133/320 (41%), Gaps = 36/320 (11%)

Query: 320  RRPEQVTWAAQEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRH--SKLSTA 377
            RR EQ+  A    + +++REQL      +EE+E   + +         EC+    +   A
Sbjct: 1196 RRQEQIQ-AMPLADSQAVREQLRQEQALLEEIERHGEKV--------EECQRFAKQYINA 1246

Query: 378  EREQALRLKSRAVELLPDGT-ANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEY---- 432
             ++  L+L +   +L P  + A   K+Q   E+  Q  + L   + +    L ++Y    
Sbjct: 1247 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE-LTTLTSQYIKFI 1305

Query: 433  -RHLRKLQDCRELESSRRLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRL 491
               LR++++   L   +R AE +E    V AA E+ R+  E + Q  ++ E   +++ + 
Sbjct: 1306 SETLRRMEEEERLAEQQR-AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR 1364

Query: 492  AYTQ--RILEIVGNIRKQKEEITKIL-----SDTKELQKEINSLSGKLDRTFAVTDE--- 541
               +  R  E   + ++QK  I + L     S   E+Q +             + +E   
Sbjct: 1365 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1424

Query: 542  ----LVFKDAKKDDAVRKAYKYLAALHENCSQLIQTIEDTGTIMREVRD---LEEQIETE 594
                L   + ++  A  +     A   E  +Q  Q  E+   + R+V+D    + Q E E
Sbjct: 1425 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1484

Query: 595  LGKKTLSNLEKIREDYRALR 614
            L  +  +  E  RE  RAL+
Sbjct: 1485 LASRVKAEAEAAREKQRALQ 1504



 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 89/389 (22%), Positives = 157/389 (40%), Gaps = 45/389 (11%)

Query: 239  EDTRAQRQRLQKQLTEHLRQSWGLLGAPIQARDLGELLQAWGAGAKTGAPKGSRFTHSEK 298
            ED   QR+RL++Q  +H         A I+ R L +L +A  + ++    KG     + +
Sbjct: 1839 EDEAFQRRRLEEQAAQH--------KADIEER-LAQLRKA--SDSELERQKG-LVEDTLR 1886

Query: 299  FTFHLEPQAQATQVSDVPATSRRPEQVTWAAQEQELESLREQLEGVNRSIEEVE---ADM 355
                +E +  A + S   A + + E       E EL  +R   E   RS E+ E   A  
Sbjct: 1887 QRRQVEEEILALKASFEKAAAGKAE------LELELGRIRSNAEDTLRSKEQAELEAARQ 1940

Query: 356  KTLGVSFV--QAESECRHSKLSTAEREQALRLKS--RAVELLPDGTANLAKLQLVVENSA 411
            + L       + E+E R  K   AE E A + K+    VE L        +L+   E  +
Sbjct: 1941 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2000

Query: 412  QRVIHLAGQWEKHRVPLLAEYRHLRKLQDCRELESSRRLAEIQELHQSVRAAAEEARRKE 471
             R + LA +  + R+    E  H   +Q  +E E  + L + Q +   +R  AE ARR  
Sbjct: 2001 ARQLQLAQEAAQKRLQ-AEEKAHAFAVQQ-KEQELQQTLQQEQSVLDQLRGEAEAARRAA 2058

Query: 472  EVYKQLMSELETLPRDVSRLAYTQRILEIVGNIRKQKEEITKILSDTKELQKEINSLSGK 531
            E  ++   + E         A ++R +E    +++  EE  +  +  +   +++   + +
Sbjct: 2059 EEAEEARVQAE------REAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2112

Query: 532  LDRTFAVTDELVFKDAKKDDAVRKAYKYLAALHENCSQLIQTIEDTGTIMREVRDLEEQI 591
                 A  ++   +  +  DA  + +K  A          QT+     + +E+  L  Q+
Sbjct: 2113 EAARRAQAEQAALRQKQAADAEMEKHKKFAE---------QTLRQKAQVEQELTTLRLQL 2163

Query: 592  ETELGKKTLSNLEKIR---EDYRALRQEN 617
            E    +K L + E  R   E   A RQ +
Sbjct: 2164 EETDHQKNLLDEELQRLKAEATEAARQRS 2192



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 59/279 (21%), Positives = 118/279 (42%), Gaps = 42/279 (15%)

Query: 330  QEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHSKLSTAE---REQALRLK 386
            +EQ  + L E+ +G  R++E      + L +S      + R +++S A+    E A R +
Sbjct: 2318 KEQMAQQLAEETQGFQRTLEAER--QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR 2375

Query: 387  SRAVE----LLPDGTANLAKLQLVV---------ENSAQRVIHLAGQWEKHRVPLLAEYR 433
             +A E    L     A   K+ LV          ++ A+R+     + E+ +  L  E +
Sbjct: 2376 KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2435

Query: 434  HLR-KLQDCRELESSRRLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRLA 492
             L+ K ++ + ++  + L E Q L QS  +  +   ++E   +Q  ++LE L +D     
Sbjct: 2436 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD----- 2490

Query: 493  YTQRILEIVGNIRKQKEEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDA 552
                             E+ K     +E Q++   +  +  R  A  +E   +  + ++ 
Sbjct: 2491 -----------------EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2533

Query: 553  VRKAYKYLAALHENCSQLIQTIEDTGTIMRE-VRDLEEQ 590
            VR+  + L  L +   Q  + + +    +RE ++ LEEQ
Sbjct: 2534 VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2572



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 52/222 (23%), Positives = 91/222 (40%), Gaps = 34/222 (15%)

Query: 381  QALRLKSRAVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQD 440
            +A RLK+ A   L +  A   +L+ + E+ A +   L  Q  +H+  +      LRK  D
Sbjct: 1812 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1871

Query: 441  CRELESSRRLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRLAYTQRILEI 500
              ELE  + L E            +  R++ +V +++++    L     + A  +  LE+
Sbjct: 1872 -SELERQKGLVE------------DTLRQRRQVEEEILA----LKASFEKAAAGKAELEL 1914

Query: 501  -VGNIRKQKEEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYKY 559
             +G IR   E+  +         KE   L     R  A  +E      ++ +A  +  K 
Sbjct: 1915 ELGRIRSNAEDTLR--------SKEQAELEAARQRQLAAEEE-----RRRREAEERVQKS 1961

Query: 560  LAALHENCSQ---LIQTIEDTGTIMREVRDLEEQIETELGKK 598
            LAA  E   Q    ++ +E     + E R L E+ E E  ++
Sbjct: 1962 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2003



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 66/291 (22%), Positives = 131/291 (45%), Gaps = 30/291 (10%)

Query: 329  AQEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHSKLSTAEREQAL-RLKS 387
            A + ELE  +  +E   R   +VE ++  L  SF +A +         AE E  L R++S
Sbjct: 1869 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA-------GKAELELELGRIRS 1921

Query: 388  RAVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQDCRELESS 447
             A + L       +K Q  +E + QR   LA + E+ R    AE R ++K     E  + 
Sbjct: 1922 NAEDTL------RSKEQAELEAARQR--QLAAEEERRRRE--AEER-VQKSLAAEEEAAR 1970

Query: 448  RRLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRLAYTQRILEIVGNIRKQ 507
            +R A ++E+ + ++A  EEARR  E  +Q  +    L ++ ++             ++++
Sbjct: 1971 QRKAALEEV-ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2029

Query: 508  KEEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYKYLAALHENC 567
            ++E+ + L   ++ Q  ++ L G+ +      +E    +  +  A R+A +    + E  
Sbjct: 2030 EQELQQTL---QQEQSVLDQLRGEAEAARRAAEE---AEEARVQAEREAAQSRRQV-EEA 2082

Query: 568  SQLIQTIEDTGTIMREVRDLEEQIETELGKKTLSNLEKIREDYRALRQENA 618
             +L Q+ E+      + +   E++  E  ++      + + +  ALRQ+ A
Sbjct: 2083 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA---ARRAQAEQAALRQKQA 2130



 Score = 39.3 bits (90), Expect = 0.011
 Identities = 64/286 (22%), Positives = 119/286 (41%), Gaps = 47/286 (16%)

Query: 331  EQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECR--HSKLSTAEREQALRLKSR 388
            EQELE  R+  EG  +     E ++  L     Q E + +    +L+  +RE A   + R
Sbjct: 1659 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1718

Query: 389  AVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQDCRELESSR 448
              EL  +     A++++++ + A+         EK +  L AE    R+L +    E++R
Sbjct: 1719 Q-ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE----EAAR 1773

Query: 449  RLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRLAYTQRILEIVGNIRKQK 508
                       +RA AEEA+R+    +QL  E     R  +     +++  I        
Sbjct: 1774 -----------LRALAEEAKRQ----RQLAEEDAARQRAEAERVLAEKLAAI-------- 1810

Query: 509  EEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYKYLAALHENCS 568
             E T++ ++ +   KE  + + +L R              +D+A ++       L E  +
Sbjct: 1811 GEATRLKTEAEIALKEKEAENERLRR------------LAEDEAFQR-----RRLEEQAA 1853

Query: 569  QLIQTIEDTGTIMREVRDLEEQIETELGKKTLSNLEKIREDYRALR 614
            Q    IE+    +R+  D E + +  L + TL    ++ E+  AL+
Sbjct: 1854 QHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1899



 Score = 37.0 bits (84), Expect = 0.055
 Identities = 79/407 (19%), Positives = 164/407 (40%), Gaps = 35/407 (8%)

Query: 230  HRTSRLPPQEDTRAQRQRLQKQLTEHLRQSWGLLGAPIQARDLGELLQAWGAGAKTGAPK 289
            H  ++   + + +  +QR+Q+++   +R+    + A  Q R + E LQ     ++     
Sbjct: 1347 HAQAKAQAEREAKELQQRMQEEV---VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA 1403

Query: 290  GSRFTHS-EKFTFHLEPQAQATQVSDVPATSRRPEQVTWAAQEQELESLREQLEGVNRSI 348
             +R   + E+    +E + +  ++  + AT R+         E EL++LR + E      
Sbjct: 1404 KARQAEAAERSRLRIEEEIRVVRLQ-LEATERQR-----GGAEGELQALRARAEEAEAQK 1457

Query: 349  EEVEADMKTLGVSFVQAESECRHSKLSTAER----EQALRLKSRAVELLPDGTANLAKLQ 404
             + + + + L           R +++  A R     +A R K RA++ L +       L+
Sbjct: 1458 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE-------LR 1510

Query: 405  LVVENSAQRVIHLAGQWEKH-RVPLLAEYRHLRKLQDCRELESSRRLAEI----QELHQS 459
            L  E + +R+     +  +  +V L    R        +    + + A++    QE H +
Sbjct: 1511 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1570

Query: 460  VRAAAEEARRKEEVYKQLMSELETLPRDVSRLAYTQRILEIVGNIRKQKEEITKILSDTK 519
            V    EEA R+ +   +     E   R++ R  +  +  E +  +R Q EE+ +  S  +
Sbjct: 1571 VAQLREEAERRAQQQAEAERAREEAERELER--WQLKANEAL-RLRLQAEEVAQQKSLAQ 1627

Query: 520  -ELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYKYLAALHENCSQLIQTIEDTG 578
             E +K+      +  R     ++ V +    +  + K  +    L E  +Q     E   
Sbjct: 1628 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ----LAEGTAQQRLAAEQEL 1683

Query: 579  TIMREVRDLEEQIETELGKKTLSNLEKIREDYRALRQENAGLLGRVR 625
              +R   +  EQ + +L ++ L+ L++        RQE    L +VR
Sbjct: 1684 IRLRAETEQGEQ-QRQLLEEELARLQREAAAATQKRQELEAELAKVR 1729



 Score = 30.8 bits (68), Expect = 3.9
 Identities = 63/277 (22%), Positives = 99/277 (35%), Gaps = 40/277 (14%)

Query: 229  VHRTSRLPPQEDTRAQRQRLQKQLTEH------------------LRQSWGLL---GAPI 267
            +HRT     ++ T  Q   +Q+Q ++H                  L+Q   LL      +
Sbjct: 2385 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2444

Query: 268  QARDLGELLQAWGA------GAKTGAPKGSRFTHSEKFTFHLEPQAQATQVSDVPATSRR 321
            Q     +LLQ   A        K    +  RF   EK       Q +  +   +    +R
Sbjct: 2445 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2504

Query: 322  PEQVTWAAQEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHSKLSTAEREQ 381
             +Q      EQE + L   +E   R   E E  ++       Q E + R  +   AE  Q
Sbjct: 2505 QQQ----QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ 2560

Query: 382  ALRLKSRAVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLL-AEYRH----LR 436
             LR + + +E      A LA  + V  +       L    +    P   AE  H    LR
Sbjct: 2561 RLREQLQLLE--EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLR 2618

Query: 437  KLQDCRELESSRRLA--EIQELHQSVRAAAEEARRKE 471
            +    + L+ +  L+  E+Q L Q      E ARR++
Sbjct: 2619 RKVSAQRLQEAGILSAEELQRLAQGHTTVDELARRED 2655


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 102/434 (23%), Positives = 171/434 (39%), Gaps = 67/434 (15%)

Query: 238  QEDTRAQRQRLQKQLTEHLRQSWGLLGAPIQARDLGELLQAWGAGAKTGAPKGSRFTHSE 297
            Q +  A + R Q +  E L+QS     A  QA+   +   A     K    + +R   +E
Sbjct: 2236 QAEREAAQSRRQVEEAERLKQS-----AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2290

Query: 298  KFTFHLEPQAQATQVSD---VPATSRRPEQVTWAAQEQELESLREQLEGVN--------- 345
            +     +  A A           T R+  QV     EQEL +LR QLE  +         
Sbjct: 2291 QAALRQKQAADAEMEKHKKFAEQTLRQKAQV-----EQELTTLRLQLEETDHQKNLLDEE 2345

Query: 346  ------------RSIEEVEADMKTLGV-----SFVQAESECRHSKLSTAEREQALRLKSR 388
                        R   +VE ++ ++ V     S ++A  E  +  L   +++   R    
Sbjct: 2346 LQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE 2405

Query: 389  AVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQDCRELESSR 448
              E +       A+L +  + +A R+  LA + +  +   LAE     K+Q  +  E++R
Sbjct: 2406 EAEKMKQVAEEAARLSVAAQEAA-RLRQLAEE-DLAQQRALAEKMLKEKMQAVQ--EATR 2461

Query: 449  RLAEIQELHQSVRAAAEEARR----KEEVYKQLMSELETLPRDVSRLAYTQRILEIVGNI 504
              AE + L Q    A E+ARR    KE++ +QL  E +   R +   A  QR LE+    
Sbjct: 2462 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLE--AERQRQLEMSAEA 2519

Query: 505  RKQKEEITKIL-------SDTKELQKEINSLSGKLDRTFAVTDELVF--------KDAKK 549
             + K  + ++         D +  +K+   +  KL RT   T E V         +    
Sbjct: 2520 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2579

Query: 550  DDA--VRKAYKYLAALHENCSQLIQTIEDTGTIMREVRDLEEQIETE-LGKKTLSNLEKI 606
             DA  +R+A   L    E   Q  + ++     M+ V+  +   ET+ L +  LS  + +
Sbjct: 2580 HDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2639

Query: 607  REDYRALRQENAGL 620
             +  R + QE A L
Sbjct: 2640 LQRERFIEQEKAKL 2653



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 72/320 (22%), Positives = 133/320 (41%), Gaps = 36/320 (11%)

Query: 320  RRPEQVTWAAQEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRH--SKLSTA 377
            RR EQ+  A    + +++REQL      +EE+E   + +         EC+    +   A
Sbjct: 1365 RRQEQIQ-AMPLADSQAVREQLRQEQALLEEIERHGEKV--------EECQRFAKQYINA 1415

Query: 378  EREQALRLKSRAVELLPDGT-ANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEY---- 432
             ++  L+L +   +L P  + A   K+Q   E+  Q  + L   + +    L ++Y    
Sbjct: 1416 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE-LTTLTSQYIKFI 1474

Query: 433  -RHLRKLQDCRELESSRRLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRL 491
               LR++++   L   +R AE +E    V AA E+ R+  E + Q  ++ E   +++ + 
Sbjct: 1475 SETLRRMEEEERLAEQQR-AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR 1533

Query: 492  AYTQ--RILEIVGNIRKQKEEITKIL-----SDTKELQKEINSLSGKLDRTFAVTDE--- 541
               +  R  E   + ++QK  I + L     S   E+Q +             + +E   
Sbjct: 1534 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1593

Query: 542  ----LVFKDAKKDDAVRKAYKYLAALHENCSQLIQTIEDTGTIMREVRD---LEEQIETE 594
                L   + ++  A  +     A   E  +Q  Q  E+   + R+V+D    + Q E E
Sbjct: 1594 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1653

Query: 595  LGKKTLSNLEKIREDYRALR 614
            L  +  +  E  RE  RAL+
Sbjct: 1654 LASRVKAEAEAAREKQRALQ 1673



 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 89/389 (22%), Positives = 157/389 (40%), Gaps = 45/389 (11%)

Query: 239  EDTRAQRQRLQKQLTEHLRQSWGLLGAPIQARDLGELLQAWGAGAKTGAPKGSRFTHSEK 298
            ED   QR+RL++Q  +H         A I+ R L +L +A  + ++    KG     + +
Sbjct: 2008 EDEAFQRRRLEEQAAQH--------KADIEER-LAQLRKA--SDSELERQKG-LVEDTLR 2055

Query: 299  FTFHLEPQAQATQVSDVPATSRRPEQVTWAAQEQELESLREQLEGVNRSIEEVE---ADM 355
                +E +  A + S   A + + E       E EL  +R   E   RS E+ E   A  
Sbjct: 2056 QRRQVEEEILALKASFEKAAAGKAE------LELELGRIRSNAEDTLRSKEQAELEAARQ 2109

Query: 356  KTLGVSFV--QAESECRHSKLSTAEREQALRLKS--RAVELLPDGTANLAKLQLVVENSA 411
            + L       + E+E R  K   AE E A + K+    VE L        +L+   E  +
Sbjct: 2110 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2169

Query: 412  QRVIHLAGQWEKHRVPLLAEYRHLRKLQDCRELESSRRLAEIQELHQSVRAAAEEARRKE 471
             R + LA +  + R+    E  H   +Q  +E E  + L + Q +   +R  AE ARR  
Sbjct: 2170 ARQLQLAQEAAQKRLQ-AEEKAHAFAVQQ-KEQELQQTLQQEQSVLDQLRGEAEAARRAA 2227

Query: 472  EVYKQLMSELETLPRDVSRLAYTQRILEIVGNIRKQKEEITKILSDTKELQKEINSLSGK 531
            E  ++   + E         A ++R +E    +++  EE  +  +  +   +++   + +
Sbjct: 2228 EEAEEARVQAE------REAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2281

Query: 532  LDRTFAVTDELVFKDAKKDDAVRKAYKYLAALHENCSQLIQTIEDTGTIMREVRDLEEQI 591
                 A  ++   +  +  DA  + +K  A          QT+     + +E+  L  Q+
Sbjct: 2282 EAARRAQAEQAALRQKQAADAEMEKHKKFAE---------QTLRQKAQVEQELTTLRLQL 2332

Query: 592  ETELGKKTLSNLEKIR---EDYRALRQEN 617
            E    +K L + E  R   E   A RQ +
Sbjct: 2333 EETDHQKNLLDEELQRLKAEATEAARQRS 2361



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 59/279 (21%), Positives = 118/279 (42%), Gaps = 42/279 (15%)

Query: 330  QEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHSKLSTAE---REQALRLK 386
            +EQ  + L E+ +G  R++E      + L +S      + R +++S A+    E A R +
Sbjct: 2487 KEQMAQQLAEETQGFQRTLEAER--QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR 2544

Query: 387  SRAVE----LLPDGTANLAKLQLVV---------ENSAQRVIHLAGQWEKHRVPLLAEYR 433
             +A E    L     A   K+ LV          ++ A+R+     + E+ +  L  E +
Sbjct: 2545 KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2604

Query: 434  HLR-KLQDCRELESSRRLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRLA 492
             L+ K ++ + ++  + L E Q L QS  +  +   ++E   +Q  ++LE L +D     
Sbjct: 2605 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD----- 2659

Query: 493  YTQRILEIVGNIRKQKEEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDA 552
                             E+ K     +E Q++   +  +  R  A  +E   +  + ++ 
Sbjct: 2660 -----------------EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2702

Query: 553  VRKAYKYLAALHENCSQLIQTIEDTGTIMRE-VRDLEEQ 590
            VR+  + L  L +   Q  + + +    +RE ++ LEEQ
Sbjct: 2703 VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2741



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 52/222 (23%), Positives = 91/222 (40%), Gaps = 34/222 (15%)

Query: 381  QALRLKSRAVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQD 440
            +A RLK+ A   L +  A   +L+ + E+ A +   L  Q  +H+  +      LRK  D
Sbjct: 1981 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 2040

Query: 441  CRELESSRRLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRLAYTQRILEI 500
              ELE  + L E            +  R++ +V +++++    L     + A  +  LE+
Sbjct: 2041 -SELERQKGLVE------------DTLRQRRQVEEEILA----LKASFEKAAAGKAELEL 2083

Query: 501  -VGNIRKQKEEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYKY 559
             +G IR   E+  +         KE   L     R  A  +E      ++ +A  +  K 
Sbjct: 2084 ELGRIRSNAEDTLR--------SKEQAELEAARQRQLAAEEE-----RRRREAEERVQKS 2130

Query: 560  LAALHENCSQ---LIQTIEDTGTIMREVRDLEEQIETELGKK 598
            LAA  E   Q    ++ +E     + E R L E+ E E  ++
Sbjct: 2131 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2172



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 66/291 (22%), Positives = 131/291 (45%), Gaps = 30/291 (10%)

Query: 329  AQEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHSKLSTAEREQAL-RLKS 387
            A + ELE  +  +E   R   +VE ++  L  SF +A +         AE E  L R++S
Sbjct: 2038 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA-------GKAELELELGRIRS 2090

Query: 388  RAVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQDCRELESS 447
             A + L       +K Q  +E + QR   LA + E+ R    AE R ++K     E  + 
Sbjct: 2091 NAEDTL------RSKEQAELEAARQR--QLAAEEERRRRE--AEER-VQKSLAAEEEAAR 2139

Query: 448  RRLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRLAYTQRILEIVGNIRKQ 507
            +R A ++E+ + ++A  EEARR  E  +Q  +    L ++ ++             ++++
Sbjct: 2140 QRKAALEEV-ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2198

Query: 508  KEEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYKYLAALHENC 567
            ++E+ + L   ++ Q  ++ L G+ +      +E    +  +  A R+A +    + E  
Sbjct: 2199 EQELQQTL---QQEQSVLDQLRGEAEAARRAAEE---AEEARVQAEREAAQSRRQV-EEA 2251

Query: 568  SQLIQTIEDTGTIMREVRDLEEQIETELGKKTLSNLEKIREDYRALRQENA 618
             +L Q+ E+      + +   E++  E  ++      + + +  ALRQ+ A
Sbjct: 2252 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA---ARRAQAEQAALRQKQA 2299



 Score = 39.3 bits (90), Expect = 0.011
 Identities = 64/286 (22%), Positives = 119/286 (41%), Gaps = 47/286 (16%)

Query: 331  EQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECR--HSKLSTAEREQALRLKSR 388
            EQELE  R+  EG  +     E ++  L     Q E + +    +L+  +RE A   + R
Sbjct: 1828 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1887

Query: 389  AVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQDCRELESSR 448
              EL  +     A++++++ + A+         EK +  L AE    R+L +    E++R
Sbjct: 1888 Q-ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE----EAAR 1942

Query: 449  RLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRLAYTQRILEIVGNIRKQK 508
                       +RA AEEA+R+    +QL  E     R  +     +++  I        
Sbjct: 1943 -----------LRALAEEAKRQ----RQLAEEDAARQRAEAERVLAEKLAAI-------- 1979

Query: 509  EEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYKYLAALHENCS 568
             E T++ ++ +   KE  + + +L R              +D+A ++       L E  +
Sbjct: 1980 GEATRLKTEAEIALKEKEAENERLRR------------LAEDEAFQR-----RRLEEQAA 2022

Query: 569  QLIQTIEDTGTIMREVRDLEEQIETELGKKTLSNLEKIREDYRALR 614
            Q    IE+    +R+  D E + +  L + TL    ++ E+  AL+
Sbjct: 2023 QHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 2068



 Score = 37.0 bits (84), Expect = 0.055
 Identities = 79/407 (19%), Positives = 164/407 (40%), Gaps = 35/407 (8%)

Query: 230  HRTSRLPPQEDTRAQRQRLQKQLTEHLRQSWGLLGAPIQARDLGELLQAWGAGAKTGAPK 289
            H  ++   + + +  +QR+Q+++   +R+    + A  Q R + E LQ     ++     
Sbjct: 1516 HAQAKAQAEREAKELQQRMQEEV---VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA 1572

Query: 290  GSRFTHS-EKFTFHLEPQAQATQVSDVPATSRRPEQVTWAAQEQELESLREQLEGVNRSI 348
             +R   + E+    +E + +  ++  + AT R+         E EL++LR + E      
Sbjct: 1573 KARQAEAAERSRLRIEEEIRVVRLQ-LEATERQR-----GGAEGELQALRARAEEAEAQK 1626

Query: 349  EEVEADMKTLGVSFVQAESECRHSKLSTAER----EQALRLKSRAVELLPDGTANLAKLQ 404
             + + + + L           R +++  A R     +A R K RA++ L +       L+
Sbjct: 1627 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE-------LR 1679

Query: 405  LVVENSAQRVIHLAGQWEKH-RVPLLAEYRHLRKLQDCRELESSRRLAEI----QELHQS 459
            L  E + +R+     +  +  +V L    R        +    + + A++    QE H +
Sbjct: 1680 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1739

Query: 460  VRAAAEEARRKEEVYKQLMSELETLPRDVSRLAYTQRILEIVGNIRKQKEEITKILSDTK 519
            V    EEA R+ +   +     E   R++ R  +  +  E +  +R Q EE+ +  S  +
Sbjct: 1740 VAQLREEAERRAQQQAEAERAREEAERELER--WQLKANEAL-RLRLQAEEVAQQKSLAQ 1796

Query: 520  -ELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYKYLAALHENCSQLIQTIEDTG 578
             E +K+      +  R     ++ V +    +  + K  +    L E  +Q     E   
Sbjct: 1797 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ----LAEGTAQQRLAAEQEL 1852

Query: 579  TIMREVRDLEEQIETELGKKTLSNLEKIREDYRALRQENAGLLGRVR 625
              +R   +  EQ + +L ++ L+ L++        RQE    L +VR
Sbjct: 1853 IRLRAETEQGEQ-QRQLLEEELARLQREAAAATQKRQELEAELAKVR 1898



 Score = 30.8 bits (68), Expect = 3.9
 Identities = 63/277 (22%), Positives = 99/277 (35%), Gaps = 40/277 (14%)

Query: 229  VHRTSRLPPQEDTRAQRQRLQKQLTEH------------------LRQSWGLL---GAPI 267
            +HRT     ++ T  Q   +Q+Q ++H                  L+Q   LL      +
Sbjct: 2554 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2613

Query: 268  QARDLGELLQAWGA------GAKTGAPKGSRFTHSEKFTFHLEPQAQATQVSDVPATSRR 321
            Q     +LLQ   A        K    +  RF   EK       Q +  +   +    +R
Sbjct: 2614 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2673

Query: 322  PEQVTWAAQEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHSKLSTAEREQ 381
             +Q      EQE + L   +E   R   E E  ++       Q E + R  +   AE  Q
Sbjct: 2674 QQQ----QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ 2729

Query: 382  ALRLKSRAVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLL-AEYRH----LR 436
             LR + + +E      A LA  + V  +       L    +    P   AE  H    LR
Sbjct: 2730 RLREQLQLLE--EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLR 2787

Query: 437  KLQDCRELESSRRLA--EIQELHQSVRAAAEEARRKE 471
            +    + L+ +  L+  E+Q L Q      E ARR++
Sbjct: 2788 RKVSAQRLQEAGILSAEELQRLAQGHTTVDELARRED 2824


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 102/434 (23%), Positives = 171/434 (39%), Gaps = 67/434 (15%)

Query: 238  QEDTRAQRQRLQKQLTEHLRQSWGLLGAPIQARDLGELLQAWGAGAKTGAPKGSRFTHSE 297
            Q +  A + R Q +  E L+QS     A  QA+   +   A     K    + +R   +E
Sbjct: 2077 QAEREAAQSRRQVEEAERLKQS-----AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2131

Query: 298  KFTFHLEPQAQATQVSD---VPATSRRPEQVTWAAQEQELESLREQLEGVN--------- 345
            +     +  A A           T R+  QV     EQEL +LR QLE  +         
Sbjct: 2132 QAALRQKQAADAEMEKHKKFAEQTLRQKAQV-----EQELTTLRLQLEETDHQKNLLDEE 2186

Query: 346  ------------RSIEEVEADMKTLGV-----SFVQAESECRHSKLSTAEREQALRLKSR 388
                        R   +VE ++ ++ V     S ++A  E  +  L   +++   R    
Sbjct: 2187 LQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE 2246

Query: 389  AVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQDCRELESSR 448
              E +       A+L +  + +A R+  LA + +  +   LAE     K+Q  +  E++R
Sbjct: 2247 EAEKMKQVAEEAARLSVAAQEAA-RLRQLAEE-DLAQQRALAEKMLKEKMQAVQ--EATR 2302

Query: 449  RLAEIQELHQSVRAAAEEARR----KEEVYKQLMSELETLPRDVSRLAYTQRILEIVGNI 504
              AE + L Q    A E+ARR    KE++ +QL  E +   R +   A  QR LE+    
Sbjct: 2303 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLE--AERQRQLEMSAEA 2360

Query: 505  RKQKEEITKIL-------SDTKELQKEINSLSGKLDRTFAVTDELVF--------KDAKK 549
             + K  + ++         D +  +K+   +  KL RT   T E V         +    
Sbjct: 2361 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2420

Query: 550  DDA--VRKAYKYLAALHENCSQLIQTIEDTGTIMREVRDLEEQIETE-LGKKTLSNLEKI 606
             DA  +R+A   L    E   Q  + ++     M+ V+  +   ET+ L +  LS  + +
Sbjct: 2421 HDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2480

Query: 607  REDYRALRQENAGL 620
             +  R + QE A L
Sbjct: 2481 LQRERFIEQEKAKL 2494



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 72/320 (22%), Positives = 133/320 (41%), Gaps = 36/320 (11%)

Query: 320  RRPEQVTWAAQEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRH--SKLSTA 377
            RR EQ+  A    + +++REQL      +EE+E   + +         EC+    +   A
Sbjct: 1206 RRQEQIQ-AMPLADSQAVREQLRQEQALLEEIERHGEKV--------EECQRFAKQYINA 1256

Query: 378  EREQALRLKSRAVELLPDGT-ANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEY---- 432
             ++  L+L +   +L P  + A   K+Q   E+  Q  + L   + +    L ++Y    
Sbjct: 1257 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE-LTTLTSQYIKFI 1315

Query: 433  -RHLRKLQDCRELESSRRLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRL 491
               LR++++   L   +R AE +E    V AA E+ R+  E + Q  ++ E   +++ + 
Sbjct: 1316 SETLRRMEEEERLAEQQR-AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR 1374

Query: 492  AYTQ--RILEIVGNIRKQKEEITKIL-----SDTKELQKEINSLSGKLDRTFAVTDE--- 541
               +  R  E   + ++QK  I + L     S   E+Q +             + +E   
Sbjct: 1375 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1434

Query: 542  ----LVFKDAKKDDAVRKAYKYLAALHENCSQLIQTIEDTGTIMREVRD---LEEQIETE 594
                L   + ++  A  +     A   E  +Q  Q  E+   + R+V+D    + Q E E
Sbjct: 1435 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1494

Query: 595  LGKKTLSNLEKIREDYRALR 614
            L  +  +  E  RE  RAL+
Sbjct: 1495 LASRVKAEAEAAREKQRALQ 1514



 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 89/389 (22%), Positives = 157/389 (40%), Gaps = 45/389 (11%)

Query: 239  EDTRAQRQRLQKQLTEHLRQSWGLLGAPIQARDLGELLQAWGAGAKTGAPKGSRFTHSEK 298
            ED   QR+RL++Q  +H         A I+ R L +L +A  + ++    KG     + +
Sbjct: 1849 EDEAFQRRRLEEQAAQH--------KADIEER-LAQLRKA--SDSELERQKG-LVEDTLR 1896

Query: 299  FTFHLEPQAQATQVSDVPATSRRPEQVTWAAQEQELESLREQLEGVNRSIEEVE---ADM 355
                +E +  A + S   A + + E       E EL  +R   E   RS E+ E   A  
Sbjct: 1897 QRRQVEEEILALKASFEKAAAGKAE------LELELGRIRSNAEDTLRSKEQAELEAARQ 1950

Query: 356  KTLGVSFV--QAESECRHSKLSTAEREQALRLKS--RAVELLPDGTANLAKLQLVVENSA 411
            + L       + E+E R  K   AE E A + K+    VE L        +L+   E  +
Sbjct: 1951 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2010

Query: 412  QRVIHLAGQWEKHRVPLLAEYRHLRKLQDCRELESSRRLAEIQELHQSVRAAAEEARRKE 471
             R + LA +  + R+    E  H   +Q  +E E  + L + Q +   +R  AE ARR  
Sbjct: 2011 ARQLQLAQEAAQKRLQ-AEEKAHAFAVQQ-KEQELQQTLQQEQSVLDQLRGEAEAARRAA 2068

Query: 472  EVYKQLMSELETLPRDVSRLAYTQRILEIVGNIRKQKEEITKILSDTKELQKEINSLSGK 531
            E  ++   + E         A ++R +E    +++  EE  +  +  +   +++   + +
Sbjct: 2069 EEAEEARVQAE------REAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2122

Query: 532  LDRTFAVTDELVFKDAKKDDAVRKAYKYLAALHENCSQLIQTIEDTGTIMREVRDLEEQI 591
                 A  ++   +  +  DA  + +K  A          QT+     + +E+  L  Q+
Sbjct: 2123 EAARRAQAEQAALRQKQAADAEMEKHKKFAE---------QTLRQKAQVEQELTTLRLQL 2173

Query: 592  ETELGKKTLSNLEKIR---EDYRALRQEN 617
            E    +K L + E  R   E   A RQ +
Sbjct: 2174 EETDHQKNLLDEELQRLKAEATEAARQRS 2202



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 59/279 (21%), Positives = 118/279 (42%), Gaps = 42/279 (15%)

Query: 330  QEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHSKLSTAE---REQALRLK 386
            +EQ  + L E+ +G  R++E      + L +S      + R +++S A+    E A R +
Sbjct: 2328 KEQMAQQLAEETQGFQRTLEAER--QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR 2385

Query: 387  SRAVE----LLPDGTANLAKLQLVV---------ENSAQRVIHLAGQWEKHRVPLLAEYR 433
             +A E    L     A   K+ LV          ++ A+R+     + E+ +  L  E +
Sbjct: 2386 KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2445

Query: 434  HLR-KLQDCRELESSRRLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRLA 492
             L+ K ++ + ++  + L E Q L QS  +  +   ++E   +Q  ++LE L +D     
Sbjct: 2446 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD----- 2500

Query: 493  YTQRILEIVGNIRKQKEEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDA 552
                             E+ K     +E Q++   +  +  R  A  +E   +  + ++ 
Sbjct: 2501 -----------------EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2543

Query: 553  VRKAYKYLAALHENCSQLIQTIEDTGTIMRE-VRDLEEQ 590
            VR+  + L  L +   Q  + + +    +RE ++ LEEQ
Sbjct: 2544 VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2582



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 52/222 (23%), Positives = 91/222 (40%), Gaps = 34/222 (15%)

Query: 381  QALRLKSRAVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQD 440
            +A RLK+ A   L +  A   +L+ + E+ A +   L  Q  +H+  +      LRK  D
Sbjct: 1822 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1881

Query: 441  CRELESSRRLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRLAYTQRILEI 500
              ELE  + L E            +  R++ +V +++++    L     + A  +  LE+
Sbjct: 1882 -SELERQKGLVE------------DTLRQRRQVEEEILA----LKASFEKAAAGKAELEL 1924

Query: 501  -VGNIRKQKEEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYKY 559
             +G IR   E+  +         KE   L     R  A  +E      ++ +A  +  K 
Sbjct: 1925 ELGRIRSNAEDTLR--------SKEQAELEAARQRQLAAEEE-----RRRREAEERVQKS 1971

Query: 560  LAALHENCSQ---LIQTIEDTGTIMREVRDLEEQIETELGKK 598
            LAA  E   Q    ++ +E     + E R L E+ E E  ++
Sbjct: 1972 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2013



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 66/291 (22%), Positives = 131/291 (45%), Gaps = 30/291 (10%)

Query: 329  AQEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHSKLSTAEREQAL-RLKS 387
            A + ELE  +  +E   R   +VE ++  L  SF +A +         AE E  L R++S
Sbjct: 1879 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA-------GKAELELELGRIRS 1931

Query: 388  RAVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQDCRELESS 447
             A + L       +K Q  +E + QR   LA + E+ R    AE R ++K     E  + 
Sbjct: 1932 NAEDTL------RSKEQAELEAARQR--QLAAEEERRRRE--AEER-VQKSLAAEEEAAR 1980

Query: 448  RRLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRLAYTQRILEIVGNIRKQ 507
            +R A ++E+ + ++A  EEARR  E  +Q  +    L ++ ++             ++++
Sbjct: 1981 QRKAALEEV-ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2039

Query: 508  KEEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYKYLAALHENC 567
            ++E+ + L   ++ Q  ++ L G+ +      +E    +  +  A R+A +    + E  
Sbjct: 2040 EQELQQTL---QQEQSVLDQLRGEAEAARRAAEE---AEEARVQAEREAAQSRRQV-EEA 2092

Query: 568  SQLIQTIEDTGTIMREVRDLEEQIETELGKKTLSNLEKIREDYRALRQENA 618
             +L Q+ E+      + +   E++  E  ++      + + +  ALRQ+ A
Sbjct: 2093 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA---ARRAQAEQAALRQKQA 2140



 Score = 39.3 bits (90), Expect = 0.011
 Identities = 64/286 (22%), Positives = 119/286 (41%), Gaps = 47/286 (16%)

Query: 331  EQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECR--HSKLSTAEREQALRLKSR 388
            EQELE  R+  EG  +     E ++  L     Q E + +    +L+  +RE A   + R
Sbjct: 1669 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1728

Query: 389  AVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQDCRELESSR 448
              EL  +     A++++++ + A+         EK +  L AE    R+L +    E++R
Sbjct: 1729 Q-ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE----EAAR 1783

Query: 449  RLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRLAYTQRILEIVGNIRKQK 508
                       +RA AEEA+R+    +QL  E     R  +     +++  I        
Sbjct: 1784 -----------LRALAEEAKRQ----RQLAEEDAARQRAEAERVLAEKLAAI-------- 1820

Query: 509  EEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYKYLAALHENCS 568
             E T++ ++ +   KE  + + +L R              +D+A ++       L E  +
Sbjct: 1821 GEATRLKTEAEIALKEKEAENERLRR------------LAEDEAFQR-----RRLEEQAA 1863

Query: 569  QLIQTIEDTGTIMREVRDLEEQIETELGKKTLSNLEKIREDYRALR 614
            Q    IE+    +R+  D E + +  L + TL    ++ E+  AL+
Sbjct: 1864 QHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1909



 Score = 37.0 bits (84), Expect = 0.055
 Identities = 79/407 (19%), Positives = 164/407 (40%), Gaps = 35/407 (8%)

Query: 230  HRTSRLPPQEDTRAQRQRLQKQLTEHLRQSWGLLGAPIQARDLGELLQAWGAGAKTGAPK 289
            H  ++   + + +  +QR+Q+++   +R+    + A  Q R + E LQ     ++     
Sbjct: 1357 HAQAKAQAEREAKELQQRMQEEV---VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA 1413

Query: 290  GSRFTHS-EKFTFHLEPQAQATQVSDVPATSRRPEQVTWAAQEQELESLREQLEGVNRSI 348
             +R   + E+    +E + +  ++  + AT R+         E EL++LR + E      
Sbjct: 1414 KARQAEAAERSRLRIEEEIRVVRLQ-LEATERQR-----GGAEGELQALRARAEEAEAQK 1467

Query: 349  EEVEADMKTLGVSFVQAESECRHSKLSTAER----EQALRLKSRAVELLPDGTANLAKLQ 404
             + + + + L           R +++  A R     +A R K RA++ L +       L+
Sbjct: 1468 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE-------LR 1520

Query: 405  LVVENSAQRVIHLAGQWEKH-RVPLLAEYRHLRKLQDCRELESSRRLAEI----QELHQS 459
            L  E + +R+     +  +  +V L    R        +    + + A++    QE H +
Sbjct: 1521 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1580

Query: 460  VRAAAEEARRKEEVYKQLMSELETLPRDVSRLAYTQRILEIVGNIRKQKEEITKILSDTK 519
            V    EEA R+ +   +     E   R++ R  +  +  E +  +R Q EE+ +  S  +
Sbjct: 1581 VAQLREEAERRAQQQAEAERAREEAERELER--WQLKANEAL-RLRLQAEEVAQQKSLAQ 1637

Query: 520  -ELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYKYLAALHENCSQLIQTIEDTG 578
             E +K+      +  R     ++ V +    +  + K  +    L E  +Q     E   
Sbjct: 1638 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ----LAEGTAQQRLAAEQEL 1693

Query: 579  TIMREVRDLEEQIETELGKKTLSNLEKIREDYRALRQENAGLLGRVR 625
              +R   +  EQ + +L ++ L+ L++        RQE    L +VR
Sbjct: 1694 IRLRAETEQGEQ-QRQLLEEELARLQREAAAATQKRQELEAELAKVR 1739



 Score = 30.8 bits (68), Expect = 3.9
 Identities = 63/277 (22%), Positives = 99/277 (35%), Gaps = 40/277 (14%)

Query: 229  VHRTSRLPPQEDTRAQRQRLQKQLTEH------------------LRQSWGLL---GAPI 267
            +HRT     ++ T  Q   +Q+Q ++H                  L+Q   LL      +
Sbjct: 2395 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2454

Query: 268  QARDLGELLQAWGA------GAKTGAPKGSRFTHSEKFTFHLEPQAQATQVSDVPATSRR 321
            Q     +LLQ   A        K    +  RF   EK       Q +  +   +    +R
Sbjct: 2455 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2514

Query: 322  PEQVTWAAQEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHSKLSTAEREQ 381
             +Q      EQE + L   +E   R   E E  ++       Q E + R  +   AE  Q
Sbjct: 2515 QQQ----QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ 2570

Query: 382  ALRLKSRAVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLL-AEYRH----LR 436
             LR + + +E      A LA  + V  +       L    +    P   AE  H    LR
Sbjct: 2571 RLREQLQLLE--EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLR 2628

Query: 437  KLQDCRELESSRRLA--EIQELHQSVRAAAEEARRKE 471
            +    + L+ +  L+  E+Q L Q      E ARR++
Sbjct: 2629 RKVSAQRLQEAGILSAEELQRLAQGHTTVDELARRED 2665


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 102/434 (23%), Positives = 171/434 (39%), Gaps = 67/434 (15%)

Query: 238  QEDTRAQRQRLQKQLTEHLRQSWGLLGAPIQARDLGELLQAWGAGAKTGAPKGSRFTHSE 297
            Q +  A + R Q +  E L+QS     A  QA+   +   A     K    + +R   +E
Sbjct: 2085 QAEREAAQSRRQVEEAERLKQS-----AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2139

Query: 298  KFTFHLEPQAQATQVSD---VPATSRRPEQVTWAAQEQELESLREQLEGVN--------- 345
            +     +  A A           T R+  QV     EQEL +LR QLE  +         
Sbjct: 2140 QAALRQKQAADAEMEKHKKFAEQTLRQKAQV-----EQELTTLRLQLEETDHQKNLLDEE 2194

Query: 346  ------------RSIEEVEADMKTLGV-----SFVQAESECRHSKLSTAEREQALRLKSR 388
                        R   +VE ++ ++ V     S ++A  E  +  L   +++   R    
Sbjct: 2195 LQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE 2254

Query: 389  AVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQDCRELESSR 448
              E +       A+L +  + +A R+  LA + +  +   LAE     K+Q  +  E++R
Sbjct: 2255 EAEKMKQVAEEAARLSVAAQEAA-RLRQLAEE-DLAQQRALAEKMLKEKMQAVQ--EATR 2310

Query: 449  RLAEIQELHQSVRAAAEEARR----KEEVYKQLMSELETLPRDVSRLAYTQRILEIVGNI 504
              AE + L Q    A E+ARR    KE++ +QL  E +   R +   A  QR LE+    
Sbjct: 2311 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLE--AERQRQLEMSAEA 2368

Query: 505  RKQKEEITKIL-------SDTKELQKEINSLSGKLDRTFAVTDELVF--------KDAKK 549
             + K  + ++         D +  +K+   +  KL RT   T E V         +    
Sbjct: 2369 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2428

Query: 550  DDA--VRKAYKYLAALHENCSQLIQTIEDTGTIMREVRDLEEQIETE-LGKKTLSNLEKI 606
             DA  +R+A   L    E   Q  + ++     M+ V+  +   ET+ L +  LS  + +
Sbjct: 2429 HDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2488

Query: 607  REDYRALRQENAGL 620
             +  R + QE A L
Sbjct: 2489 LQRERFIEQEKAKL 2502



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 72/320 (22%), Positives = 133/320 (41%), Gaps = 36/320 (11%)

Query: 320  RRPEQVTWAAQEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRH--SKLSTA 377
            RR EQ+  A    + +++REQL      +EE+E   + +         EC+    +   A
Sbjct: 1214 RRQEQIQ-AMPLADSQAVREQLRQEQALLEEIERHGEKV--------EECQRFAKQYINA 1264

Query: 378  EREQALRLKSRAVELLPDGT-ANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEY---- 432
             ++  L+L +   +L P  + A   K+Q   E+  Q  + L   + +    L ++Y    
Sbjct: 1265 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE-LTTLTSQYIKFI 1323

Query: 433  -RHLRKLQDCRELESSRRLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRL 491
               LR++++   L   +R AE +E    V AA E+ R+  E + Q  ++ E   +++ + 
Sbjct: 1324 SETLRRMEEEERLAEQQR-AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR 1382

Query: 492  AYTQ--RILEIVGNIRKQKEEITKIL-----SDTKELQKEINSLSGKLDRTFAVTDE--- 541
               +  R  E   + ++QK  I + L     S   E+Q +             + +E   
Sbjct: 1383 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1442

Query: 542  ----LVFKDAKKDDAVRKAYKYLAALHENCSQLIQTIEDTGTIMREVRD---LEEQIETE 594
                L   + ++  A  +     A   E  +Q  Q  E+   + R+V+D    + Q E E
Sbjct: 1443 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1502

Query: 595  LGKKTLSNLEKIREDYRALR 614
            L  +  +  E  RE  RAL+
Sbjct: 1503 LASRVKAEAEAAREKQRALQ 1522



 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 89/389 (22%), Positives = 157/389 (40%), Gaps = 45/389 (11%)

Query: 239  EDTRAQRQRLQKQLTEHLRQSWGLLGAPIQARDLGELLQAWGAGAKTGAPKGSRFTHSEK 298
            ED   QR+RL++Q  +H         A I+ R L +L +A  + ++    KG     + +
Sbjct: 1857 EDEAFQRRRLEEQAAQH--------KADIEER-LAQLRKA--SDSELERQKG-LVEDTLR 1904

Query: 299  FTFHLEPQAQATQVSDVPATSRRPEQVTWAAQEQELESLREQLEGVNRSIEEVE---ADM 355
                +E +  A + S   A + + E       E EL  +R   E   RS E+ E   A  
Sbjct: 1905 QRRQVEEEILALKASFEKAAAGKAE------LELELGRIRSNAEDTLRSKEQAELEAARQ 1958

Query: 356  KTLGVSFV--QAESECRHSKLSTAEREQALRLKS--RAVELLPDGTANLAKLQLVVENSA 411
            + L       + E+E R  K   AE E A + K+    VE L        +L+   E  +
Sbjct: 1959 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2018

Query: 412  QRVIHLAGQWEKHRVPLLAEYRHLRKLQDCRELESSRRLAEIQELHQSVRAAAEEARRKE 471
             R + LA +  + R+    E  H   +Q  +E E  + L + Q +   +R  AE ARR  
Sbjct: 2019 ARQLQLAQEAAQKRLQ-AEEKAHAFAVQQ-KEQELQQTLQQEQSVLDQLRGEAEAARRAA 2076

Query: 472  EVYKQLMSELETLPRDVSRLAYTQRILEIVGNIRKQKEEITKILSDTKELQKEINSLSGK 531
            E  ++   + E         A ++R +E    +++  EE  +  +  +   +++   + +
Sbjct: 2077 EEAEEARVQAE------REAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2130

Query: 532  LDRTFAVTDELVFKDAKKDDAVRKAYKYLAALHENCSQLIQTIEDTGTIMREVRDLEEQI 591
                 A  ++   +  +  DA  + +K  A          QT+     + +E+  L  Q+
Sbjct: 2131 EAARRAQAEQAALRQKQAADAEMEKHKKFAE---------QTLRQKAQVEQELTTLRLQL 2181

Query: 592  ETELGKKTLSNLEKIR---EDYRALRQEN 617
            E    +K L + E  R   E   A RQ +
Sbjct: 2182 EETDHQKNLLDEELQRLKAEATEAARQRS 2210



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 59/279 (21%), Positives = 118/279 (42%), Gaps = 42/279 (15%)

Query: 330  QEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHSKLSTAE---REQALRLK 386
            +EQ  + L E+ +G  R++E      + L +S      + R +++S A+    E A R +
Sbjct: 2336 KEQMAQQLAEETQGFQRTLEAER--QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR 2393

Query: 387  SRAVE----LLPDGTANLAKLQLVV---------ENSAQRVIHLAGQWEKHRVPLLAEYR 433
             +A E    L     A   K+ LV          ++ A+R+     + E+ +  L  E +
Sbjct: 2394 KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2453

Query: 434  HLR-KLQDCRELESSRRLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRLA 492
             L+ K ++ + ++  + L E Q L QS  +  +   ++E   +Q  ++LE L +D     
Sbjct: 2454 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD----- 2508

Query: 493  YTQRILEIVGNIRKQKEEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDA 552
                             E+ K     +E Q++   +  +  R  A  +E   +  + ++ 
Sbjct: 2509 -----------------EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2551

Query: 553  VRKAYKYLAALHENCSQLIQTIEDTGTIMRE-VRDLEEQ 590
            VR+  + L  L +   Q  + + +    +RE ++ LEEQ
Sbjct: 2552 VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2590



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 52/222 (23%), Positives = 91/222 (40%), Gaps = 34/222 (15%)

Query: 381  QALRLKSRAVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQD 440
            +A RLK+ A   L +  A   +L+ + E+ A +   L  Q  +H+  +      LRK  D
Sbjct: 1830 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1889

Query: 441  CRELESSRRLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRLAYTQRILEI 500
              ELE  + L E            +  R++ +V +++++    L     + A  +  LE+
Sbjct: 1890 -SELERQKGLVE------------DTLRQRRQVEEEILA----LKASFEKAAAGKAELEL 1932

Query: 501  -VGNIRKQKEEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYKY 559
             +G IR   E+  +         KE   L     R  A  +E      ++ +A  +  K 
Sbjct: 1933 ELGRIRSNAEDTLR--------SKEQAELEAARQRQLAAEEE-----RRRREAEERVQKS 1979

Query: 560  LAALHENCSQ---LIQTIEDTGTIMREVRDLEEQIETELGKK 598
            LAA  E   Q    ++ +E     + E R L E+ E E  ++
Sbjct: 1980 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2021



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 66/291 (22%), Positives = 131/291 (45%), Gaps = 30/291 (10%)

Query: 329  AQEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHSKLSTAEREQAL-RLKS 387
            A + ELE  +  +E   R   +VE ++  L  SF +A +         AE E  L R++S
Sbjct: 1887 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA-------GKAELELELGRIRS 1939

Query: 388  RAVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQDCRELESS 447
             A + L       +K Q  +E + QR   LA + E+ R    AE R ++K     E  + 
Sbjct: 1940 NAEDTL------RSKEQAELEAARQR--QLAAEEERRRRE--AEER-VQKSLAAEEEAAR 1988

Query: 448  RRLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRLAYTQRILEIVGNIRKQ 507
            +R A ++E+ + ++A  EEARR  E  +Q  +    L ++ ++             ++++
Sbjct: 1989 QRKAALEEV-ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2047

Query: 508  KEEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYKYLAALHENC 567
            ++E+ + L   ++ Q  ++ L G+ +      +E    +  +  A R+A +    + E  
Sbjct: 2048 EQELQQTL---QQEQSVLDQLRGEAEAARRAAEE---AEEARVQAEREAAQSRRQV-EEA 2100

Query: 568  SQLIQTIEDTGTIMREVRDLEEQIETELGKKTLSNLEKIREDYRALRQENA 618
             +L Q+ E+      + +   E++  E  ++      + + +  ALRQ+ A
Sbjct: 2101 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA---ARRAQAEQAALRQKQA 2148



 Score = 39.3 bits (90), Expect = 0.011
 Identities = 64/286 (22%), Positives = 119/286 (41%), Gaps = 47/286 (16%)

Query: 331  EQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECR--HSKLSTAEREQALRLKSR 388
            EQELE  R+  EG  +     E ++  L     Q E + +    +L+  +RE A   + R
Sbjct: 1677 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1736

Query: 389  AVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQDCRELESSR 448
              EL  +     A++++++ + A+         EK +  L AE    R+L +    E++R
Sbjct: 1737 Q-ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE----EAAR 1791

Query: 449  RLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRLAYTQRILEIVGNIRKQK 508
                       +RA AEEA+R+    +QL  E     R  +     +++  I        
Sbjct: 1792 -----------LRALAEEAKRQ----RQLAEEDAARQRAEAERVLAEKLAAI-------- 1828

Query: 509  EEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYKYLAALHENCS 568
             E T++ ++ +   KE  + + +L R              +D+A ++       L E  +
Sbjct: 1829 GEATRLKTEAEIALKEKEAENERLRR------------LAEDEAFQR-----RRLEEQAA 1871

Query: 569  QLIQTIEDTGTIMREVRDLEEQIETELGKKTLSNLEKIREDYRALR 614
            Q    IE+    +R+  D E + +  L + TL    ++ E+  AL+
Sbjct: 1872 QHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1917



 Score = 37.0 bits (84), Expect = 0.055
 Identities = 79/407 (19%), Positives = 164/407 (40%), Gaps = 35/407 (8%)

Query: 230  HRTSRLPPQEDTRAQRQRLQKQLTEHLRQSWGLLGAPIQARDLGELLQAWGAGAKTGAPK 289
            H  ++   + + +  +QR+Q+++   +R+    + A  Q R + E LQ     ++     
Sbjct: 1365 HAQAKAQAEREAKELQQRMQEEV---VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA 1421

Query: 290  GSRFTHS-EKFTFHLEPQAQATQVSDVPATSRRPEQVTWAAQEQELESLREQLEGVNRSI 348
             +R   + E+    +E + +  ++  + AT R+         E EL++LR + E      
Sbjct: 1422 KARQAEAAERSRLRIEEEIRVVRLQ-LEATERQR-----GGAEGELQALRARAEEAEAQK 1475

Query: 349  EEVEADMKTLGVSFVQAESECRHSKLSTAER----EQALRLKSRAVELLPDGTANLAKLQ 404
             + + + + L           R +++  A R     +A R K RA++ L +       L+
Sbjct: 1476 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE-------LR 1528

Query: 405  LVVENSAQRVIHLAGQWEKH-RVPLLAEYRHLRKLQDCRELESSRRLAEI----QELHQS 459
            L  E + +R+     +  +  +V L    R        +    + + A++    QE H +
Sbjct: 1529 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1588

Query: 460  VRAAAEEARRKEEVYKQLMSELETLPRDVSRLAYTQRILEIVGNIRKQKEEITKILSDTK 519
            V    EEA R+ +   +     E   R++ R  +  +  E +  +R Q EE+ +  S  +
Sbjct: 1589 VAQLREEAERRAQQQAEAERAREEAERELER--WQLKANEAL-RLRLQAEEVAQQKSLAQ 1645

Query: 520  -ELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYKYLAALHENCSQLIQTIEDTG 578
             E +K+      +  R     ++ V +    +  + K  +    L E  +Q     E   
Sbjct: 1646 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ----LAEGTAQQRLAAEQEL 1701

Query: 579  TIMREVRDLEEQIETELGKKTLSNLEKIREDYRALRQENAGLLGRVR 625
              +R   +  EQ + +L ++ L+ L++        RQE    L +VR
Sbjct: 1702 IRLRAETEQGEQ-QRQLLEEELARLQREAAAATQKRQELEAELAKVR 1747



 Score = 30.8 bits (68), Expect = 3.9
 Identities = 63/277 (22%), Positives = 99/277 (35%), Gaps = 40/277 (14%)

Query: 229  VHRTSRLPPQEDTRAQRQRLQKQLTEH------------------LRQSWGLL---GAPI 267
            +HRT     ++ T  Q   +Q+Q ++H                  L+Q   LL      +
Sbjct: 2403 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2462

Query: 268  QARDLGELLQAWGA------GAKTGAPKGSRFTHSEKFTFHLEPQAQATQVSDVPATSRR 321
            Q     +LLQ   A        K    +  RF   EK       Q +  +   +    +R
Sbjct: 2463 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2522

Query: 322  PEQVTWAAQEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHSKLSTAEREQ 381
             +Q      EQE + L   +E   R   E E  ++       Q E + R  +   AE  Q
Sbjct: 2523 QQQ----QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ 2578

Query: 382  ALRLKSRAVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLL-AEYRH----LR 436
             LR + + +E      A LA  + V  +       L    +    P   AE  H    LR
Sbjct: 2579 RLREQLQLLE--EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLR 2636

Query: 437  KLQDCRELESSRRLA--EIQELHQSVRAAAEEARRKE 471
            +    + L+ +  L+  E+Q L Q      E ARR++
Sbjct: 2637 RKVSAQRLQEAGILSAEELQRLAQGHTTVDELARRED 2673


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 102/434 (23%), Positives = 171/434 (39%), Gaps = 67/434 (15%)

Query: 238  QEDTRAQRQRLQKQLTEHLRQSWGLLGAPIQARDLGELLQAWGAGAKTGAPKGSRFTHSE 297
            Q +  A + R Q +  E L+QS     A  QA+   +   A     K    + +R   +E
Sbjct: 2126 QAEREAAQSRRQVEEAERLKQS-----AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2180

Query: 298  KFTFHLEPQAQATQVSD---VPATSRRPEQVTWAAQEQELESLREQLEGVN--------- 345
            +     +  A A           T R+  QV     EQEL +LR QLE  +         
Sbjct: 2181 QAALRQKQAADAEMEKHKKFAEQTLRQKAQV-----EQELTTLRLQLEETDHQKNLLDEE 2235

Query: 346  ------------RSIEEVEADMKTLGV-----SFVQAESECRHSKLSTAEREQALRLKSR 388
                        R   +VE ++ ++ V     S ++A  E  +  L   +++   R    
Sbjct: 2236 LQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE 2295

Query: 389  AVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQDCRELESSR 448
              E +       A+L +  + +A R+  LA + +  +   LAE     K+Q  +  E++R
Sbjct: 2296 EAEKMKQVAEEAARLSVAAQEAA-RLRQLAEE-DLAQQRALAEKMLKEKMQAVQ--EATR 2351

Query: 449  RLAEIQELHQSVRAAAEEARR----KEEVYKQLMSELETLPRDVSRLAYTQRILEIVGNI 504
              AE + L Q    A E+ARR    KE++ +QL  E +   R +   A  QR LE+    
Sbjct: 2352 LKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLE--AERQRQLEMSAEA 2409

Query: 505  RKQKEEITKIL-------SDTKELQKEINSLSGKLDRTFAVTDELVF--------KDAKK 549
             + K  + ++         D +  +K+   +  KL RT   T E V         +    
Sbjct: 2410 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2469

Query: 550  DDA--VRKAYKYLAALHENCSQLIQTIEDTGTIMREVRDLEEQIETE-LGKKTLSNLEKI 606
             DA  +R+A   L    E   Q  + ++     M+ V+  +   ET+ L +  LS  + +
Sbjct: 2470 HDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2529

Query: 607  REDYRALRQENAGL 620
             +  R + QE A L
Sbjct: 2530 LQRERFIEQEKAKL 2543



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 72/320 (22%), Positives = 133/320 (41%), Gaps = 36/320 (11%)

Query: 320  RRPEQVTWAAQEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRH--SKLSTA 377
            RR EQ+  A    + +++REQL      +EE+E   + +         EC+    +   A
Sbjct: 1255 RRQEQIQ-AMPLADSQAVREQLRQEQALLEEIERHGEKV--------EECQRFAKQYINA 1305

Query: 378  EREQALRLKSRAVELLPDGT-ANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEY---- 432
             ++  L+L +   +L P  + A   K+Q   E+  Q  + L   + +    L ++Y    
Sbjct: 1306 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE-LTTLTSQYIKFI 1364

Query: 433  -RHLRKLQDCRELESSRRLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRL 491
               LR++++   L   +R AE +E    V AA E+ R+  E + Q  ++ E   +++ + 
Sbjct: 1365 SETLRRMEEEERLAEQQR-AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR 1423

Query: 492  AYTQ--RILEIVGNIRKQKEEITKIL-----SDTKELQKEINSLSGKLDRTFAVTDE--- 541
               +  R  E   + ++QK  I + L     S   E+Q +             + +E   
Sbjct: 1424 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1483

Query: 542  ----LVFKDAKKDDAVRKAYKYLAALHENCSQLIQTIEDTGTIMREVRD---LEEQIETE 594
                L   + ++  A  +     A   E  +Q  Q  E+   + R+V+D    + Q E E
Sbjct: 1484 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1543

Query: 595  LGKKTLSNLEKIREDYRALR 614
            L  +  +  E  RE  RAL+
Sbjct: 1544 LASRVKAEAEAAREKQRALQ 1563



 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 89/389 (22%), Positives = 157/389 (40%), Gaps = 45/389 (11%)

Query: 239  EDTRAQRQRLQKQLTEHLRQSWGLLGAPIQARDLGELLQAWGAGAKTGAPKGSRFTHSEK 298
            ED   QR+RL++Q  +H         A I+ R L +L +A  + ++    KG     + +
Sbjct: 1898 EDEAFQRRRLEEQAAQH--------KADIEER-LAQLRKA--SDSELERQKG-LVEDTLR 1945

Query: 299  FTFHLEPQAQATQVSDVPATSRRPEQVTWAAQEQELESLREQLEGVNRSIEEVE---ADM 355
                +E +  A + S   A + + E       E EL  +R   E   RS E+ E   A  
Sbjct: 1946 QRRQVEEEILALKASFEKAAAGKAE------LELELGRIRSNAEDTLRSKEQAELEAARQ 1999

Query: 356  KTLGVSFV--QAESECRHSKLSTAEREQALRLKS--RAVELLPDGTANLAKLQLVVENSA 411
            + L       + E+E R  K   AE E A + K+    VE L        +L+   E  +
Sbjct: 2000 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2059

Query: 412  QRVIHLAGQWEKHRVPLLAEYRHLRKLQDCRELESSRRLAEIQELHQSVRAAAEEARRKE 471
             R + LA +  + R+    E  H   +Q  +E E  + L + Q +   +R  AE ARR  
Sbjct: 2060 ARQLQLAQEAAQKRLQ-AEEKAHAFAVQQ-KEQELQQTLQQEQSVLDQLRGEAEAARRAA 2117

Query: 472  EVYKQLMSELETLPRDVSRLAYTQRILEIVGNIRKQKEEITKILSDTKELQKEINSLSGK 531
            E  ++   + E         A ++R +E    +++  EE  +  +  +   +++   + +
Sbjct: 2118 EEAEEARVQAE------REAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2171

Query: 532  LDRTFAVTDELVFKDAKKDDAVRKAYKYLAALHENCSQLIQTIEDTGTIMREVRDLEEQI 591
                 A  ++   +  +  DA  + +K  A          QT+     + +E+  L  Q+
Sbjct: 2172 EAARRAQAEQAALRQKQAADAEMEKHKKFAE---------QTLRQKAQVEQELTTLRLQL 2222

Query: 592  ETELGKKTLSNLEKIR---EDYRALRQEN 617
            E    +K L + E  R   E   A RQ +
Sbjct: 2223 EETDHQKNLLDEELQRLKAEATEAARQRS 2251



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 59/279 (21%), Positives = 118/279 (42%), Gaps = 42/279 (15%)

Query: 330  QEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHSKLSTAE---REQALRLK 386
            +EQ  + L E+ +G  R++E      + L +S      + R +++S A+    E A R +
Sbjct: 2377 KEQMAQQLAEETQGFQRTLEAER--QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFR 2434

Query: 387  SRAVE----LLPDGTANLAKLQLVV---------ENSAQRVIHLAGQWEKHRVPLLAEYR 433
             +A E    L     A   K+ LV          ++ A+R+     + E+ +  L  E +
Sbjct: 2435 KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2494

Query: 434  HLR-KLQDCRELESSRRLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRLA 492
             L+ K ++ + ++  + L E Q L QS  +  +   ++E   +Q  ++LE L +D     
Sbjct: 2495 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD----- 2549

Query: 493  YTQRILEIVGNIRKQKEEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDA 552
                             E+ K     +E Q++   +  +  R  A  +E   +  + ++ 
Sbjct: 2550 -----------------EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2592

Query: 553  VRKAYKYLAALHENCSQLIQTIEDTGTIMRE-VRDLEEQ 590
            VR+  + L  L +   Q  + + +    +RE ++ LEEQ
Sbjct: 2593 VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2631



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 52/222 (23%), Positives = 91/222 (40%), Gaps = 34/222 (15%)

Query: 381  QALRLKSRAVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQD 440
            +A RLK+ A   L +  A   +L+ + E+ A +   L  Q  +H+  +      LRK  D
Sbjct: 1871 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1930

Query: 441  CRELESSRRLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRLAYTQRILEI 500
              ELE  + L E            +  R++ +V +++++    L     + A  +  LE+
Sbjct: 1931 -SELERQKGLVE------------DTLRQRRQVEEEILA----LKASFEKAAAGKAELEL 1973

Query: 501  -VGNIRKQKEEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYKY 559
             +G IR   E+  +         KE   L     R  A  +E      ++ +A  +  K 
Sbjct: 1974 ELGRIRSNAEDTLR--------SKEQAELEAARQRQLAAEEE-----RRRREAEERVQKS 2020

Query: 560  LAALHENCSQ---LIQTIEDTGTIMREVRDLEEQIETELGKK 598
            LAA  E   Q    ++ +E     + E R L E+ E E  ++
Sbjct: 2021 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2062



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 66/291 (22%), Positives = 131/291 (45%), Gaps = 30/291 (10%)

Query: 329  AQEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHSKLSTAEREQAL-RLKS 387
            A + ELE  +  +E   R   +VE ++  L  SF +A +         AE E  L R++S
Sbjct: 1928 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAA-------GKAELELELGRIRS 1980

Query: 388  RAVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQDCRELESS 447
             A + L       +K Q  +E + QR   LA + E+ R    AE R ++K     E  + 
Sbjct: 1981 NAEDTL------RSKEQAELEAARQR--QLAAEEERRRRE--AEER-VQKSLAAEEEAAR 2029

Query: 448  RRLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRLAYTQRILEIVGNIRKQ 507
            +R A ++E+ + ++A  EEARR  E  +Q  +    L ++ ++             ++++
Sbjct: 2030 QRKAALEEV-ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2088

Query: 508  KEEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYKYLAALHENC 567
            ++E+ + L   ++ Q  ++ L G+ +      +E    +  +  A R+A +    + E  
Sbjct: 2089 EQELQQTL---QQEQSVLDQLRGEAEAARRAAEE---AEEARVQAEREAAQSRRQV-EEA 2141

Query: 568  SQLIQTIEDTGTIMREVRDLEEQIETELGKKTLSNLEKIREDYRALRQENA 618
             +L Q+ E+      + +   E++  E  ++      + + +  ALRQ+ A
Sbjct: 2142 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA---ARRAQAEQAALRQKQA 2189



 Score = 39.3 bits (90), Expect = 0.011
 Identities = 64/286 (22%), Positives = 119/286 (41%), Gaps = 47/286 (16%)

Query: 331  EQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECR--HSKLSTAEREQALRLKSR 388
            EQELE  R+  EG  +     E ++  L     Q E + +    +L+  +RE A   + R
Sbjct: 1718 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1777

Query: 389  AVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQDCRELESSR 448
              EL  +     A++++++ + A+         EK +  L AE    R+L +    E++R
Sbjct: 1778 Q-ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE----EAAR 1832

Query: 449  RLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRLAYTQRILEIVGNIRKQK 508
                       +RA AEEA+R+    +QL  E     R  +     +++  I        
Sbjct: 1833 -----------LRALAEEAKRQ----RQLAEEDAARQRAEAERVLAEKLAAI-------- 1869

Query: 509  EEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYKYLAALHENCS 568
             E T++ ++ +   KE  + + +L R              +D+A ++       L E  +
Sbjct: 1870 GEATRLKTEAEIALKEKEAENERLRR------------LAEDEAFQR-----RRLEEQAA 1912

Query: 569  QLIQTIEDTGTIMREVRDLEEQIETELGKKTLSNLEKIREDYRALR 614
            Q    IE+    +R+  D E + +  L + TL    ++ E+  AL+
Sbjct: 1913 QHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1958



 Score = 37.0 bits (84), Expect = 0.055
 Identities = 79/407 (19%), Positives = 164/407 (40%), Gaps = 35/407 (8%)

Query: 230  HRTSRLPPQEDTRAQRQRLQKQLTEHLRQSWGLLGAPIQARDLGELLQAWGAGAKTGAPK 289
            H  ++   + + +  +QR+Q+++   +R+    + A  Q R + E LQ     ++     
Sbjct: 1406 HAQAKAQAEREAKELQQRMQEEV---VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA 1462

Query: 290  GSRFTHS-EKFTFHLEPQAQATQVSDVPATSRRPEQVTWAAQEQELESLREQLEGVNRSI 348
             +R   + E+    +E + +  ++  + AT R+         E EL++LR + E      
Sbjct: 1463 KARQAEAAERSRLRIEEEIRVVRLQ-LEATERQR-----GGAEGELQALRARAEEAEAQK 1516

Query: 349  EEVEADMKTLGVSFVQAESECRHSKLSTAER----EQALRLKSRAVELLPDGTANLAKLQ 404
             + + + + L           R +++  A R     +A R K RA++ L +       L+
Sbjct: 1517 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE-------LR 1569

Query: 405  LVVENSAQRVIHLAGQWEKH-RVPLLAEYRHLRKLQDCRELESSRRLAEI----QELHQS 459
            L  E + +R+     +  +  +V L    R        +    + + A++    QE H +
Sbjct: 1570 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1629

Query: 460  VRAAAEEARRKEEVYKQLMSELETLPRDVSRLAYTQRILEIVGNIRKQKEEITKILSDTK 519
            V    EEA R+ +   +     E   R++ R  +  +  E +  +R Q EE+ +  S  +
Sbjct: 1630 VAQLREEAERRAQQQAEAERAREEAERELER--WQLKANEAL-RLRLQAEEVAQQKSLAQ 1686

Query: 520  -ELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYKYLAALHENCSQLIQTIEDTG 578
             E +K+      +  R     ++ V +    +  + K  +    L E  +Q     E   
Sbjct: 1687 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ----LAEGTAQQRLAAEQEL 1742

Query: 579  TIMREVRDLEEQIETELGKKTLSNLEKIREDYRALRQENAGLLGRVR 625
              +R   +  EQ + +L ++ L+ L++        RQE    L +VR
Sbjct: 1743 IRLRAETEQGEQ-QRQLLEEELARLQREAAAATQKRQELEAELAKVR 1788



 Score = 30.8 bits (68), Expect = 3.9
 Identities = 63/277 (22%), Positives = 99/277 (35%), Gaps = 40/277 (14%)

Query: 229  VHRTSRLPPQEDTRAQRQRLQKQLTEH------------------LRQSWGLL---GAPI 267
            +HRT     ++ T  Q   +Q+Q ++H                  L+Q   LL      +
Sbjct: 2444 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2503

Query: 268  QARDLGELLQAWGA------GAKTGAPKGSRFTHSEKFTFHLEPQAQATQVSDVPATSRR 321
            Q     +LLQ   A        K    +  RF   EK       Q +  +   +    +R
Sbjct: 2504 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2563

Query: 322  PEQVTWAAQEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHSKLSTAEREQ 381
             +Q      EQE + L   +E   R   E E  ++       Q E + R  +   AE  Q
Sbjct: 2564 QQQ----QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ 2619

Query: 382  ALRLKSRAVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLL-AEYRH----LR 436
             LR + + +E      A LA  + V  +       L    +    P   AE  H    LR
Sbjct: 2620 RLREQLQLLE--EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLR 2677

Query: 437  KLQDCRELESSRRLA--EIQELHQSVRAAAEEARRKE 471
            +    + L+ +  L+  E+Q L Q      E ARR++
Sbjct: 2678 RKVSAQRLQEAGILSAEELQRLAQGHTTVDELARRED 2714


>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
            sapiens]
          Length = 1940

 Score = 53.9 bits (128), Expect = 4e-07
 Identities = 80/359 (22%), Positives = 143/359 (39%), Gaps = 53/359 (14%)

Query: 297  EKFTFHLEPQAQATQVSDVPATSRRPEQVTWAAQEQELESLREQLEGVNRSIEEVEADMK 356
            EK  F LE    ++ +  V  +    E++          +L +QL       EE++  + 
Sbjct: 1221 EKSEFKLEIDDLSSSMESVSKSKANLEKIC--------RTLEDQLSEARGKNEEIQRSLS 1272

Query: 357  TLGVSFVQAESECRHSKLSTAEREQALRLKSRAVELLPDGTANLAKLQLVVENSAQRVIH 416
             L     + ++E         E+E  +   SR+ +     T  L K QL  EN A+  + 
Sbjct: 1273 ELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEEL-KRQLEEENKAKNALA 1331

Query: 417  LAGQWEKHRVPLLAE------------YRHLRK----------------LQDCREL-ESS 447
             A Q  +H   LL E             R L K                +Q   EL E+ 
Sbjct: 1332 HALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAK 1391

Query: 448  RRLAE-IQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRLAYTQRILEIVGNIRK 506
            ++LA+ +Q+  + V A   +    E+  ++L  E+E L  DV      +R   +   + K
Sbjct: 1392 KKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDV------ERANSLAAALDK 1445

Query: 507  QKEEITKILSDTKELQKEINS-LSGKLDRTFAVTDELV-FKDAKKD--DAVRKAYKYLAA 562
            ++    K+L++ K   +E  + L   L  + +++ EL   K+A ++  D +    +    
Sbjct: 1446 KQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKN 1505

Query: 563  LHENCSQLIQTIEDTGTIMREVRDLEEQIETELGKKTLSNLEKIREDYRALRQENAGLL 621
            L +  + L + I + G  + E+    +QIE E     L+    + E   AL  E A +L
Sbjct: 1506 LEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLA----LEEAEAALEHEEAKIL 1560



 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 72/319 (22%), Positives = 134/319 (42%), Gaps = 43/319 (13%)

Query: 332  QELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHSKLSTAEREQALRLKSRAVE 391
            +EL++  E+LE      EE+EA+  T   +  Q     R  +  +   E+A  + S  +E
Sbjct: 1110 KELQARIEELE------EEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIE 1163

Query: 392  LLPDGTANLAKLQLVVENSA-QRVIHLAGQWEKHR---VPLLAEYRHLRKLQDCRELESS 447
            L     A   KL+  +E +  Q    +A   +KH      L  +  +L++++   E E S
Sbjct: 1164 LNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKS 1223

Query: 448  RRLAEIQELHQSVRAAAEEARRKEEVYKQLMSEL-------ETLPRDVSRL-AYTQRILE 499
                EI +L  S+ + ++     E++ + L  +L       E + R +S L     R+  
Sbjct: 1224 EFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQT 1283

Query: 500  IVGNIRKQKEEITKILS-----------DTKELQKEI-------NSLSGKLDRTFAVTDE 541
              G + +Q EE   I+S            T+EL++++       N+L+  L  +    D 
Sbjct: 1284 EAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDL 1343

Query: 542  LVFKDAKKDDAVRKAYKYLAALHENCSQLIQTIEDTGTIMREVRDLEEQIETELGKKTLS 601
            L  +  ++ +   +  + L+  +   +Q  +T  +T  I R      E++E E  KK   
Sbjct: 1344 LREQYEEEQEGKAELQRALSKANSEVAQW-RTKYETDAIQR-----TEELE-EAKKKLAQ 1396

Query: 602  NLEKIREDYRALRQENAGL 620
             L+   E   A+  + A L
Sbjct: 1397 RLQDSEEQVEAVNAKCASL 1415



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 74/399 (18%), Positives = 158/399 (39%), Gaps = 25/399 (6%)

Query: 240  DTRAQRQRLQKQLTEHLRQSWGLLGAPIQARDLGELLQAWGAGAKTGAPKGSRFTH-SEK 298
            + R + + +Q+ L+E   Q   L     +A +L   L+   +     +     FT  +E+
Sbjct: 1259 EARGKNEEIQRSLSELTTQKSRL---QTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEE 1315

Query: 299  FTFHLEPQAQATQ-VSDVPATSRRPEQVTWAAQEQELESLREQLEGVNRSIEEVEADMKT 357
                LE + +A   ++    +SR    +     E+E E   E    ++++  EV      
Sbjct: 1316 LKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTK 1375

Query: 358  LGVSFVQAESECRHSKLSTAEREQALRLKSRAVELLPDGTANLAKLQLVVENSAQRVIHL 417
                 +Q   E   +K   A+R   L+     VE +    A+L K +  ++   + ++  
Sbjct: 1376 YETDAIQRTEELEEAKKKLAQR---LQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVD 1432

Query: 418  AGQWEKHRVPLLAEYRHLRKLQDCRELESSRRLAEIQELHQSVRAAAEEARRKEEVYKQL 477
              +       L  + R+  K+    + +     AE++   +  R+ + E  + +  Y++ 
Sbjct: 1433 VERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEA 1492

Query: 478  MSELETLPRDVSRLAYTQRILEIVGNIRKQKEEITKILSDTKELQKEINSLSGKLDRTFA 537
            + +LET+ R+   L   Q I ++   I +  + I ++    K+++ E   +   L+   A
Sbjct: 1493 LDQLETVKRENKNL--EQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEA 1550

Query: 538  VTD-----------ELVFKDAKKDDAVRKAYKYLAALHENCSQLIQTIEDTGTIMREVRD 586
              +           EL    ++ D  + +  + +  L  N  + ++T++    +  EVR 
Sbjct: 1551 ALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQ--SALDAEVRS 1608

Query: 587  LEEQIETELGKKTLSNLEKIREDYRALRQENAGLLGRVR 625
              E I   L KK   +L +I        ++ A  L  +R
Sbjct: 1609 RNEAI--RLKKKMEGDLNEIEIQLSHANRQAAETLKHLR 1645



 Score = 38.5 bits (88), Expect = 0.019
 Identities = 65/298 (21%), Positives = 121/298 (40%), Gaps = 52/298 (17%)

Query: 331  EQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHSKLSTAEREQALR-----L 385
            ++ +E+++  L+   RS  E     K +     + E +  H+    AE  + LR     L
Sbjct: 1592 QRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQL 1651

Query: 386  KSRAVEL--LPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQDCRE 443
            K   + L     G  +L +   +VE  A     L  + E+ R  L  +    RKL +   
Sbjct: 1652 KDTQLHLDDALRGQEDLKEQLAIVERRANL---LQAEVEELRATL-EQTERARKLAEQEL 1707

Query: 444  LESSRRLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDV------SRLAYTQRI 497
            L+S+ R   +Q LH    +     ++ E    QL SE+E   RD       ++ A T   
Sbjct: 1708 LDSNER---VQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAA 1764

Query: 498  LEIVGNIRKQKEEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAY 557
            + +   ++K+++    +    K L++ +  L  +LD      ++L  K  KK        
Sbjct: 1765 M-MAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDE----AEQLALKGGKKQ------- 1812

Query: 558  KYLAALHENCSQLIQTIEDTGTIMREVRDLEEQIETELGKKTLSNLEKIREDYRALRQ 615
                         IQ +E        +R+LE ++E E  KK   +++ +R+  R +++
Sbjct: 1813 -------------IQKLE------TRIRELEFELEGE-QKKNTESVKGLRKYERRVKE 1850


>gi|42794779 myosin 18A isoform b [Homo sapiens]
          Length = 2039

 Score = 53.9 bits (128), Expect = 4e-07
 Identities = 58/271 (21%), Positives = 119/271 (43%), Gaps = 26/271 (9%)

Query: 333  ELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHSKLSTAEREQALRLKSRAVEL 392
            EL+  +  LEG      E+E   +       QA  E +  KL   +RE+  R K   +  
Sbjct: 1438 ELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKL---QREKLQREKDMLLAE 1494

Query: 393  LPDGTANLAKLQLVVENSAQRVIHL-------AGQWEKHRVPLLAEYRHLRKLQ---DCR 442
                   L +  + +    Q+V+ L       + Q  K    L    + LR L+     +
Sbjct: 1495 AFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQ 1554

Query: 443  ELESSRRLAEIQELHQS-VRAAAEEARRKEEVYKQLMSELETLPRDVSRLAYTQRILEIV 501
            E E   +   IQ L Q+ +R   E  R ++   K++ S  E +  + +R +  +++ ++ 
Sbjct: 1555 EEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEV--EEARQSCQKKLKQME 1612

Query: 502  GNIRKQKEEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYKYLA 561
              + ++ E+  K+L + +EL+ ++ +LS +++R          +D + +  +RK  K   
Sbjct: 1613 VQLEEEYEDKQKVLREKRELEGKLATLSDQVNR----------RDFESEKRLRKDLKRTK 1662

Query: 562  ALHENCSQLIQTIEDTGTIMREVRDLEEQIE 592
            AL  +   ++  ++++    RE+  L+ Q+E
Sbjct: 1663 ALLADAQLMLDHLKNSAPSKREIAQLKNQLE 1693



 Score = 39.7 bits (91), Expect = 0.008
 Identities = 57/305 (18%), Positives = 137/305 (44%), Gaps = 29/305 (9%)

Query: 312  VSDVPATSRRPEQVTWAAQEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRH 371
            V +V  T +R +Q      E +LE  ++    + R + +++AD +    +  Q + +C+ 
Sbjct: 1379 VREVDFTKKRLQQEF----EDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQ- 1433

Query: 372  SKLSTAEREQALRLKSRAVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAE 431
             +L+   ++  L L+ + V         L K Q   ++   +  H   Q EK       +
Sbjct: 1434 -RLTAELQDTKLHLEGQQVR-----NHELEKKQRRFDSELSQA-HEEAQREK------LQ 1480

Query: 432  YRHLRKLQDCRELESSRRLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRL 491
               L++ +D    E+     +++E    +    ++    E   + + S+     +D + L
Sbjct: 1481 REKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQES---KDEASL 1537

Query: 492  AYTQRIL-EIVGNIRKQKEEITKILSDTKELQKEINSLSGKLDRTFAV-TDELVFKDAKK 549
            A  ++ L ++   ++ Q+EE+ +     + L++    L  +++R     + E+  +D + 
Sbjct: 1538 AKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEV 1597

Query: 550  DDAVRKAYKYLAALHENCSQLIQTIEDTGTIMREVRDLEEQIET---ELGKKTLSNLEKI 606
            ++A +   K L  +     QL +  ED   ++RE R+LE ++ T   ++ ++   + +++
Sbjct: 1598 EEARQSCQKKLKQMEV---QLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRL 1654

Query: 607  REDYR 611
            R+D +
Sbjct: 1655 RKDLK 1659



 Score = 33.1 bits (74), Expect = 0.79
 Identities = 44/183 (24%), Positives = 77/183 (42%), Gaps = 33/183 (18%)

Query: 329  AQEQELESLREQLEGVNRSIEEVEADMKTL----------------GVSFVQAE-SECRH 371
            A E++L  L+ +   +   +EE + DM  L                 ++ +QA+  E   
Sbjct: 1729 ALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANK 1788

Query: 372  SKLSTAEREQALRLKSRAVE-------LLPDGTANLAKLQLVVE---NSAQRVIHLAGQW 421
             K    E+ QAL+ +   +E       L+    A + +L+  +E      +R+  LA + 
Sbjct: 1789 EKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLASRL 1848

Query: 422  EKHRVPLLAEYRHLRKLQDCRELESSRRLAE-----IQELHQSVRAAAEEARRKEEVYKQ 476
             K  +  L E R  R   + RE E ++RL        +E+ +  R  AE +R+K E+   
Sbjct: 1849 -KENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMD 1907

Query: 477  LMS 479
            L S
Sbjct: 1908 LES 1910


>gi|28416946 myosin 18A isoform a [Homo sapiens]
          Length = 2054

 Score = 53.9 bits (128), Expect = 4e-07
 Identities = 58/271 (21%), Positives = 119/271 (43%), Gaps = 26/271 (9%)

Query: 333  ELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHSKLSTAEREQALRLKSRAVEL 392
            EL+  +  LEG      E+E   +       QA  E +  KL   +RE+  R K   +  
Sbjct: 1438 ELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKL---QREKLQREKDMLLAE 1494

Query: 393  LPDGTANLAKLQLVVENSAQRVIHL-------AGQWEKHRVPLLAEYRHLRKLQ---DCR 442
                   L +  + +    Q+V+ L       + Q  K    L    + LR L+     +
Sbjct: 1495 AFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQ 1554

Query: 443  ELESSRRLAEIQELHQS-VRAAAEEARRKEEVYKQLMSELETLPRDVSRLAYTQRILEIV 501
            E E   +   IQ L Q+ +R   E  R ++   K++ S  E +  + +R +  +++ ++ 
Sbjct: 1555 EEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEV--EEARQSCQKKLKQME 1612

Query: 502  GNIRKQKEEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYKYLA 561
              + ++ E+  K+L + +EL+ ++ +LS +++R          +D + +  +RK  K   
Sbjct: 1613 VQLEEEYEDKQKVLREKRELEGKLATLSDQVNR----------RDFESEKRLRKDLKRTK 1662

Query: 562  ALHENCSQLIQTIEDTGTIMREVRDLEEQIE 592
            AL  +   ++  ++++    RE+  L+ Q+E
Sbjct: 1663 ALLADAQLMLDHLKNSAPSKREIAQLKNQLE 1693



 Score = 39.7 bits (91), Expect = 0.008
 Identities = 57/305 (18%), Positives = 137/305 (44%), Gaps = 29/305 (9%)

Query: 312  VSDVPATSRRPEQVTWAAQEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRH 371
            V +V  T +R +Q      E +LE  ++    + R + +++AD +    +  Q + +C+ 
Sbjct: 1379 VREVDFTKKRLQQEF----EDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQ- 1433

Query: 372  SKLSTAEREQALRLKSRAVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAE 431
             +L+   ++  L L+ + V         L K Q   ++   +  H   Q EK       +
Sbjct: 1434 -RLTAELQDTKLHLEGQQVR-----NHELEKKQRRFDSELSQA-HEEAQREK------LQ 1480

Query: 432  YRHLRKLQDCRELESSRRLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRL 491
               L++ +D    E+     +++E    +    ++    E   + + S+     +D + L
Sbjct: 1481 REKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQES---KDEASL 1537

Query: 492  AYTQRIL-EIVGNIRKQKEEITKILSDTKELQKEINSLSGKLDRTFAV-TDELVFKDAKK 549
            A  ++ L ++   ++ Q+EE+ +     + L++    L  +++R     + E+  +D + 
Sbjct: 1538 AKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEV 1597

Query: 550  DDAVRKAYKYLAALHENCSQLIQTIEDTGTIMREVRDLEEQIET---ELGKKTLSNLEKI 606
            ++A +   K L  +     QL +  ED   ++RE R+LE ++ T   ++ ++   + +++
Sbjct: 1598 EEARQSCQKKLKQMEV---QLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRL 1654

Query: 607  REDYR 611
            R+D +
Sbjct: 1655 RKDLK 1659



 Score = 35.8 bits (81), Expect = 0.12
 Identities = 55/244 (22%), Positives = 100/244 (40%), Gaps = 40/244 (16%)

Query: 329  AQEQELESLREQLEGVNRSIEEVEADMKTL----------------GVSFVQAE-SECRH 371
            A E++L  L+ +   +   +EE + DM  L                 ++ +QA+  E   
Sbjct: 1729 ALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANK 1788

Query: 372  SKLSTAEREQALRLKSRAVE-------LLPDGTANLAKLQLVVE---NSAQRVIHLAGQW 421
             K    E+ QAL+ +   +E       L+    A + +L+  +E      +R+  LA + 
Sbjct: 1789 EKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLASRL 1848

Query: 422  EKHRVPLLAEYRHLRKLQDCRELESSRRLAE-----IQELHQSVRAAAEEARRKEEV--- 473
             K  +  L E R  R   + RE E ++RL        +E+ +  R  AE +R+K E+   
Sbjct: 1849 -KENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMD 1907

Query: 474  YKQLMSELETLPRDV----SRLAYTQRILEIVGNIRKQKEEITKILSDTKELQKEINSLS 529
             + L +  ++L  D+     R+   Q  +E      + ++ I  +     + QK  N L 
Sbjct: 1908 LESLEAANQSLQADLKLAFKRIGDLQAAIEDEMESDENEDLINSLQDMVTKYQKRKNKLE 1967

Query: 530  GKLD 533
            G  D
Sbjct: 1968 GDSD 1971


>gi|56550043 sarcolemma associated protein [Homo sapiens]
          Length = 811

 Score = 53.9 bits (128), Expect = 4e-07
 Identities = 68/311 (21%), Positives = 132/311 (42%), Gaps = 37/311 (11%)

Query: 311 QVSDVPATSRRPEQVTWAAQEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECR 370
           +  ++  TS++      A  E+E ++ R Q+E   + I+ ++A ++ L +       E  
Sbjct: 491 EAQELARTSKQKCFELQALLEEERKAYRNQVEESTKQIQVLQAQLQRLHIDTENLREEKD 550

Query: 371 HSKLSTAE-----REQALRLKSRAVELLPDGTANLAKLQ---LVVENSAQRVIHLAGQWE 422
               ST +     R++ L L   A ++  +   ++A LQ     V    +R    A ++E
Sbjct: 551 SEITSTRDELLSARDEILLLHQAAAKVASERDTDIASLQEELKKVRAELERWRKAASEYE 610

Query: 423 KHRVPLLAEYR-HLRKLQDCRELESSRRLAEIQELHQSVRAAAEEARRKEEVYKQLMSEL 481
           K    L   ++   ++ +D +  E++R   E+++L +   A   E    +     L SEL
Sbjct: 611 KEITSLQNSFQLRCQQCEDQQREEATRLQGELEKLRKEWNALETECHSLKRENVLLSSEL 670

Query: 482 ETLPRDVSRLAYTQRILEIVGNIRKQKEEITKILS----DTKELQKEINSLSGKLDRTFA 537
           +   +++              N +KQ  E+T  LS      KEL+ ++ SL  +  R  A
Sbjct: 671 QRQEKELH-------------NSQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDSA 717

Query: 538 VTDELVFKDAKKDDAVRKAYKYLAALHENCSQLIQTIEDTGTIMREVRDLEEQIETELGK 597
               L+ K   +   V+K Y           +  QT+     +  E+ + E+Q  T+  K
Sbjct: 718 DLKTLLSKAENQAKDVQKEY-----------EKTQTVLSELKLKFEMTEQEKQSITDELK 766

Query: 598 KTLSNLEKIRE 608
           +  +NL+ +RE
Sbjct: 767 QCKNNLKLLRE 777



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 47/207 (22%), Positives = 92/207 (44%), Gaps = 17/207 (8%)

Query: 328 AAQEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHSKLSTAEREQALRLKS 387
           A+ ++EL+ +R +LE   ++  E E ++ +L  SF     + R  +    +RE+A RL+ 
Sbjct: 586 ASLQEELKKVRAELERWRKAASEYEKEITSLQNSF-----QLRCQQCEDQQREEATRLQG 640

Query: 388 RAVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPL-LAEYRHLRKLQDCRELES 446
              +L  +  A    L+    +  +  + L+ + ++    L  ++ + L    D   L+ 
Sbjct: 641 ELEKLRKEWNA----LETECHSLKRENVLLSSELQRQEKELHNSQKQSLELTSDLSILQM 696

Query: 447 SRRLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSR-LAYTQRIL-EIVGNI 504
           SR+     EL   V +  E+  R     K L+S+ E   +DV +    TQ +L E+    
Sbjct: 697 SRK-----ELENQVGSLKEQHLRDSADLKTLLSKAENQAKDVQKEYEKTQTVLSELKLKF 751

Query: 505 RKQKEEITKILSDTKELQKEINSLSGK 531
              ++E   I  + K+ +  +  L  K
Sbjct: 752 EMTEQEKQSITDELKQCKNNLKLLREK 778


>gi|73623035 sperm associated antigen 5 [Homo sapiens]
          Length = 1193

 Score = 53.1 bits (126), Expect = 7e-07
 Identities = 88/404 (21%), Positives = 161/404 (39%), Gaps = 49/404 (12%)

Query: 236 PPQEDTRAQRQRLQKQLT---EHLRQSWGLLGAPIQARDLGELLQAWGAGAKTGAPKGSR 292
           P  +D+  Q       +T   +HL++S  +  A  QAR++   +Q+W   +K        
Sbjct: 464 PETQDSSTQTDTSHSGITNKLQHLKESHEMGQALQQARNV---MQSWVLISK------EL 514

Query: 293 FTHSEKFTFHLEPQAQATQVSDVPATSRRPEQVTWAAQEQELESLREQLEGVNRSIEEV- 351
            +       HLE        + V   SRR E +     +  L+ LR +L+ +    EE  
Sbjct: 515 ISLLHLSLLHLEEDK-----TTVSQESRRAETLVCCCFDL-LKKLRAKLQSLKAEREEAR 568

Query: 352 ---EADMKTLGVSFVQAESECRHSKLSTAEREQALRLKSRAVELLPDGTANLAKLQLVVE 408
              E  ++    + +  E+ C H+    ++ EQ L        LL D    L  L    E
Sbjct: 569 HREEMALRGKDAAEIVLEAFCAHASQRISQLEQDLASMREFRGLLKDAQTQLVGLHAKQE 628

Query: 409 NSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQDCRELESSRRLAEIQELHQSVRAAAEEAR 468
              Q+ + L    ++    +  +Y     L       + +   + Q+  Q    A EE +
Sbjct: 629 ELVQQTVSLTSTLQQDWRSMQLDYTTWTALLSRSRQLTEKLTVKSQQALQERDVAIEEKQ 688

Query: 469 RKEEVYKQLMSELETLPRDVSRLAYTQRILEIVGNIRKQKEEITKILSDTKELQKEINSL 528
               V +Q+ ++LE       +L        +  ++R Q + +  + S  KELQ +    
Sbjct: 689 EVSRVLEQVSAQLEECKGQTEQLELENS--RLATDLRAQLQILANMDSQLKELQSQHTHC 746

Query: 529 SGKLDRTFAVTDELVFK--DAKKDDAVRKAYKYLAALHENCSQLIQTIEDTGTIMREVRD 586
           +  L    A+ DEL+ +   + ++ A +   + +A  H       +  +    + +EVRD
Sbjct: 747 AQDL----AMKDELLCQLTQSNEEQAAQWQKEEMALKHMQA----ELQQQQAVLAKEVRD 798

Query: 587 LEEQIE----------TELGK---KTLSNLEKIREDYRALRQEN 617
           L+E +E           ELG+   +  + LE +RE  R+L+ EN
Sbjct: 799 LKETLEFADQENQVAHLELGQVECQLKTTLEVLRE--RSLQCEN 840


>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
            sapiens]
          Length = 1935

 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 73/316 (23%), Positives = 125/316 (39%), Gaps = 43/316 (13%)

Query: 306  QAQATQVSDVPATSRRPEQVT----WAAQEQELESLREQLEGVNRSIEEVEADMKTLGVS 361
            +A+ TQ S    TS+R +  T     + Q  E E+L  QL     +  +   D+K     
Sbjct: 1262 KAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEE 1321

Query: 362  FVQAESECRHSKLSTAEREQALRLKSRAVELLPDGTANLAKLQLVVENSAQRVIHLAGQW 421
             V+A++   H+  S       LR      E   + T   A+LQ V+  +   V     ++
Sbjct: 1322 EVKAKNALAHALQSARHDCDLLR------EQYEEETEAKAELQRVLSKANSEVAQWRTKY 1375

Query: 422  EKHRVPLLAEYRHLRKLQDCRELESSRRLAE-IQELHQSVRAAAEEARRKEEVYKQLMSE 480
            E   +    E             E+ ++LA+ +QE  ++V A   +    E+   +L +E
Sbjct: 1376 ETDAIQRTEELE-----------EAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNE 1424

Query: 481  LETLPRDVSRLAYTQRILEIVGNIRKQKEEITKILSDTKELQKEINSLSGKLDRTFAVTD 540
            +E L  DV R       L+      K++    KIL++ K+  +E  S             
Sbjct: 1425 IEDLMVDVERSNAAAAALD------KKQRNFDKILAEWKQKYEESQS------------- 1465

Query: 541  ELVFKDAKKDDAVRKAYKYLAALHENCSQLIQTIEDTGTIMREVRDLEEQIETELGKKTL 600
            EL     +      + +K   A  E+   L     +   +  E+ DL EQ+ +    KT+
Sbjct: 1466 ELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGS--SGKTI 1523

Query: 601  SNLEKIREDYRALRQE 616
              LEK+R+   A + E
Sbjct: 1524 HELEKVRKQLEAEKME 1539



 Score = 39.3 bits (90), Expect = 0.011
 Identities = 68/336 (20%), Positives = 136/336 (40%), Gaps = 62/336 (18%)

Query: 331  EQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHSKLSTAERE-QALRLKSRA 389
            ++E+  L EQL    ++I E+E   K L    ++ +S    ++ S    E + LR +   
Sbjct: 1506 QEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEF 1565

Query: 390  VELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRH-------LRKLQ-DC 441
             ++  +    LA+    +E + +  + +    +  +  L AE R         +K++ D 
Sbjct: 1566 NQIKAEIERKLAEKDEEMEQAKRNHLRVV---DSLQTSLDAETRSRNEALRVKKKMEGDL 1622

Query: 442  REL------------ESSRRLAEIQELHQSVRAAAEEARRKEEVYKQ-----------LM 478
             E+            E+ +++  +Q L +  +   ++A R  +  K+           L 
Sbjct: 1623 NEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQ 1682

Query: 479  SELETLPRDV-----SRLAYTQRILEIVGNIRKQKEEITKILSDTKELQKEINSLSGKLD 533
            +ELE L   V     SR    Q ++E    ++    + T +++  K++  +++ L  +++
Sbjct: 1683 AELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVE 1742

Query: 534  RTF------------AVTDELVFKDAKKDDAVRKAYKYLAALHENCSQLIQTIEDTGTIM 581
                           A+TD  +  +  K +    A+     L      + QTI+D    +
Sbjct: 1743 EAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAH-----LERMKKNMEQTIKD----L 1793

Query: 582  REVRDLEEQIETELGKKTLSNLE-KIREDYRALRQE 616
            +   D  EQI  + GKK L  LE ++RE    L  E
Sbjct: 1794 QHRLDEAEQIALKGGKKQLQKLEARVRELENELEAE 1829



 Score = 38.5 bits (88), Expect = 0.019
 Identities = 50/237 (21%), Positives = 107/237 (45%), Gaps = 16/237 (6%)

Query: 306  QAQATQVSDVPATSRRPEQVTWAAQEQELESLREQ---LEGVNRSI----EEVEADMKTL 358
            QA+  ++  V   + R  ++     EQEL    E+   L   N S+    ++++AD+  L
Sbjct: 1682 QAELEELRAVVEQTERSRKLA----EQELIETSERVQLLHSQNTSLINQKKKMDADLSQL 1737

Query: 359  GVSFVQAESECRHSKLSTAEREQALRLKSRAVELLPDGTANLAKLQLVVENSAQRVIHLA 418
                 +A  ECR+++    +      + +  ++   D +A+L +++  +E + + + H  
Sbjct: 1738 QTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRL 1797

Query: 419  GQWEKHRVPLLAEYRHLRKLQ-DCRELESSRRLAEIQELHQSVRAAAEEARRKEEVYKQL 477
               E  ++ L    + L+KL+   RELE+    AE +   +SV+   +  RR +E+  Q 
Sbjct: 1798 D--EAEQIALKGGKKQLQKLEARVRELENELE-AEQKRNAESVKGMRKSERRIKELTYQT 1854

Query: 478  MSELETLPRDVSRLAYTQ-RILEIVGNIRKQKEEITKILSDTKELQKEINSLSGKLD 533
              + + L R    +   Q ++        + +E+    LS  +++Q E++    + D
Sbjct: 1855 EEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERAD 1911



 Score = 36.2 bits (82), Expect = 0.093
 Identities = 48/209 (22%), Positives = 95/209 (45%), Gaps = 12/209 (5%)

Query: 335  ESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHSK---LSTAEREQALRLKSRA-V 390
            + L+E +  V R    ++A+++ L     Q E   + ++   + T+ER Q L  ++ + +
Sbjct: 1665 DDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLI 1724

Query: 391  ELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQDCR-ELESSRR 449
                   A+L++LQ  VE + Q   +   + +K           L+K QD    LE  ++
Sbjct: 1725 NQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK 1784

Query: 450  LAE--IQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRL--AYTQRILEIVGNIR 505
              E  I++L   +  A + A +     K+ + +LE   R++     A  +R  E V  +R
Sbjct: 1785 NMEQTIKDLQHRLDEAEQIALKGG---KKQLQKLEARVRELENELEAEQKRNAESVKGMR 1841

Query: 506  KQKEEITKILSDTKELQKEINSLSGKLDR 534
            K +  I ++   T+E +K +  L   +D+
Sbjct: 1842 KSERRIKELTYQTEEDRKNLLRLQDLVDK 1870



 Score = 35.8 bits (81), Expect = 0.12
 Identities = 60/326 (18%), Positives = 133/326 (40%), Gaps = 30/326 (9%)

Query: 329  AQEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQA--ESECRHSKLSTA--------- 377
            A E ++++L E++ G++  I ++  + K L  +  QA  + +    K++T          
Sbjct: 970  ATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQ 1029

Query: 378  ---------EREQALRLKSRAVELLPDGTANLAKLQLV-VENSAQRVIHLAGQWEKHRVP 427
                     E+E+ +R+     +   +G   L +  ++ +EN  Q++     + +     
Sbjct: 1030 QVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNA 1089

Query: 428  LLAEYRHLRKLQDCRELESSRRLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRD 487
            L A     + L    + +     A I+EL + + A      + E++   L  ELE +   
Sbjct: 1090 LNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISER 1149

Query: 488  VSRLAYTQRILEIVGNIRKQKEEITKILSDTKE--LQKEINSLSGK---LDRTFAVTDEL 542
            +        + +I  N +K++ E  K+  D +E  LQ E  + + +    D    + +++
Sbjct: 1150 LEEAGGATSV-QIEMN-KKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQI 1207

Query: 543  VFKDAKKDDAVRKAYKYLAALHENCSQLIQTIEDTGTIMREVRDLEEQIETELGK--KTL 600
                  K    ++  ++   L +  S + Q I+    + +  R LE+Q+     K  +T 
Sbjct: 1208 DNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQ 1267

Query: 601  SNLEKIREDYRALRQENAGLLGRVRE 626
             ++  +      L+ EN  L  ++ E
Sbjct: 1268 RSVNDLTSQRAKLQTENGELSRQLDE 1293


>gi|55770834 centromere protein F [Homo sapiens]
          Length = 3114

 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 71/333 (21%), Positives = 136/333 (40%), Gaps = 42/333 (12%)

Query: 333  ELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHSKLSTAEREQAL--------R 384
            E+E+L+ Q+E + RS++  E D+ TL         + +  +   +E ++ L         
Sbjct: 2183 EVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEE 2242

Query: 385  LKSRAVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRV------PLLAEYRHLR-- 436
             +   +++  +    +  LQ  ++   + V  L G  E  +       P + E   LR  
Sbjct: 2243 KEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNS 2302

Query: 437  --KLQDCRELESSRRLAEIQELHQS------VRAAAEEARRKEEVYK-----------QL 477
              KL+   E +  ++L  +Q+L +S      ++   E   R+ E+ +             
Sbjct: 2303 IEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENS 2362

Query: 478  MSELETLPRDVSRLAYTQRILEI-VGNIRKQKEEITKILSDTKELQKEINSLSGKLDRTF 536
              E+ETL   +  +  + R LE+ V  IR +KE +T  L   +E   E+  ++   +   
Sbjct: 2363 KGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENIL 2422

Query: 537  AVTD-ELVFKDAKKDDAVRKAYKYLAALHENCSQLIQTIEDTGTIMREVRDLEEQIE-TE 594
               + E V    K   A+      L  L+E  + L     D      + ++L  Q+E  E
Sbjct: 2423 QEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAAL---HNDQEACKAKEQNLSSQVECLE 2479

Query: 595  LGK-KTLSNLEKIREDYRALRQENAGLLGRVRE 626
            L K + L  L++ + +Y  L+    GL+  V +
Sbjct: 2480 LEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVED 2512



 Score = 36.2 bits (82), Expect = 0.093
 Identities = 50/243 (20%), Positives = 96/243 (39%), Gaps = 46/243 (18%)

Query: 330  QEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHSKLSTAEREQALRLKSRA 389
            +E+EL+ L +++E     I+E++     L  S  + +       L   E    + L  R 
Sbjct: 909  KEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKRE 968

Query: 390  VELLP---------DGTANLAKLQLV---------VENSAQRVIHLAGQWEKHRVPLLAE 431
            +E L          + + N  K+ L+         ++   + +  L+ Q+++ ++ LL  
Sbjct: 969  IEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQR 1028

Query: 432  -------YRHLRK---------------LQDCRELESSRRLAEIQELHQSVRAAAEEARR 469
                   Y  L +               L +C  L  +R+  E+++L ++     +E   
Sbjct: 1029 CEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRK-NELEQLKEAFAKEHQEFLT 1087

Query: 470  K----EEVYKQLMSELETLPRDVSRLAYTQRILEIVGNIRKQKEEITKILSDTKELQKEI 525
            K    EE  + LM ELET+ +   R   T             K+EI  +  +  ++QKE+
Sbjct: 1088 KLAFAEERNQNLMLELETV-QQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEV 1146

Query: 526  NSL 528
            N L
Sbjct: 1147 NDL 1149



 Score = 33.1 bits (74), Expect = 0.79
 Identities = 62/320 (19%), Positives = 127/320 (39%), Gaps = 57/320 (17%)

Query: 329 AQEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHSKLSTAEREQALRLKSR 388
           AQ QEL +   +LE     ++  E +MK     F + + +   +K+   E+E+       
Sbjct: 285 AQNQELRNKINELE---LRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEK------- 334

Query: 389 AVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQDCRELESSR 448
                            V+      ++    Q+++      A  + L+KL +  +L   R
Sbjct: 335 -----------------VLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTE--DLSCQR 375

Query: 449 RLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRL--AYTQRILEIVGNIRK 506
           + AE        +   +E   +EE+ +Q  S  +TL ++  ++    TQ + +       
Sbjct: 376 QNAESARCSLEQKIKEKEKEFQEELSRQQRS-FQTLDQECIQMKARLTQELQQAKNMHNV 434

Query: 507 QKEEITKILSDTKELQKEINSLSGKL---DRTFAVT----DEL--VFKDAKKDDAVRKAY 557
            + E+ K+ S  ++L+  +     KL   ++ F  +    +EL    ++ KK++ + K++
Sbjct: 435 LQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSH 494

Query: 558 K--------YLAALHENCSQLIQTIEDTGTIMRE--------VRDLEEQIETELGKKTLS 601
                    +L A  +N  Q +   ++    M+         +RDL+E+I  +    TL 
Sbjct: 495 SEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLE 554

Query: 602 NLEKIREDYRALRQENAGLL 621
            L+    D    R  +  LL
Sbjct: 555 KLKLAVADLEKQRDCSQDLL 574



 Score = 32.7 bits (73), Expect = 1.0
 Identities = 51/294 (17%), Positives = 127/294 (43%), Gaps = 20/294 (6%)

Query: 331  EQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHSKLSTAEREQALRLKSRAV 390
            +++L S   Q+EG ++  +E   +++ L V   Q     +    S  +  + L+   + +
Sbjct: 2534 QEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNL 2593

Query: 391  ELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQDCRELESSRRL 450
            E   + T  + K+  V + +         Q E H +      +   +LQ+    E +R  
Sbjct: 2594 ENELELT-KMDKMSFVEKVNKMTAKETELQREMHEMA-----QKTAELQEELSGEKNRLA 2647

Query: 451  AEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRLAYTQRILEIVGNIRKQKEE 510
             E+Q L + ++++ ++ +       +L   L+ + +D  ++    ++ E +   + +  E
Sbjct: 2648 GELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKD--QVEKEGKVREEIAEYQLRLHE 2705

Query: 511  ITK-----ILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYKYLAALHE 565
              K     +L   K+ + EI +   KL       +E +     + D ++ + + L    +
Sbjct: 2706 AEKKHQALLLDTNKQYEVEIQTYREKL----TSKEECLSSQKLEIDLLKSSKEELNNSLK 2761

Query: 566  NCSQLIQTIEDTG-TIMREVRDLEEQIETELGKKTL--SNLEKIREDYRALRQE 616
              +Q+++ ++ T    ++ V  L+++ E   GK  L   + +++ E+   L++E
Sbjct: 2762 ATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKE 2815


>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
            transmembrane signal), 1 [Homo sapiens]
          Length = 3259

 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 75/321 (23%), Positives = 136/321 (42%), Gaps = 57/321 (17%)

Query: 330  QEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHSKLSTAEREQALRLKSRA 389
            ++QE++ L++        I  +E  +K L   FVQ ES+         + E      ++A
Sbjct: 2017 KQQEVKQLQKDCIRYQEKISALERTVKAL--EFVQTESQ--------KDLEITKENLAQA 2066

Query: 390  VELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRK-LQDCRELESSR 448
            VE      A LA  +++++++         Q E  RV  LA+   L+K LQ  +E   S+
Sbjct: 2067 VEHRKKAQAELASFKVLLDDT---------QSEAARV--LADNLKLKKELQSNKESVKSQ 2115

Query: 449  RLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRLAYTQRILEIVGN----- 503
               + ++L + +  A EE   KE+  K +  +L+ L R+   L  T   +++  N     
Sbjct: 2116 MKQKDEDLERRLEQA-EEKHLKEK--KNMQEKLDALRREKVHLEETIGEIQVTLNKKDKE 2172

Query: 504  IRKQKEEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYKYLAAL 563
            +++ +E +   ++      K ++SL    DR   V DE    + K  DA++   + +   
Sbjct: 2173 VQQLQENLDSTVTQLAAFTKSMSSLQDDRDR---VIDEAKKWERKFSDAIQSKEEEIRLK 2229

Query: 564  HENCSQLIQTIEDTGTIMREVR-------------DLEEQIETEL-----------GKKT 599
             +NCS L   +      M E++             + + Q E +L            K+ 
Sbjct: 2230 EDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKEL 2289

Query: 600  LSNLEKIREDYRALRQENAGL 620
            LS LE+ R  Y + + E A L
Sbjct: 2290 LSQLEETRHLYHSSQNELAKL 2310



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 67/328 (20%), Positives = 142/328 (43%), Gaps = 43/328 (13%)

Query: 330  QEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHSKLSTAEREQALRLKSRA 389
            + +E+  L+EQ   +N+   E+E+ +KT     V  E+E     L   ++ ++ +L+   
Sbjct: 1335 KSEEVFQLQEQ---INKQGLEIES-LKT-----VSHEAEVHAESLQ--QKLESSQLQIAG 1383

Query: 390  VELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQDC-------- 441
            +E L +    L +LQ ++    + V +L+GQ  +    L      + + +D         
Sbjct: 1384 LEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQL 1443

Query: 442  --RELESSRRLAEIQ----ELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRLAYTQ 495
              +  E   R+ ++Q    E+ Q      EE+R K+++ ++L + L +    +      Q
Sbjct: 1444 EMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQ 1503

Query: 496  RILEIV-GNIRKQKEEITKILSDTKELQKEINSLSGKL-------DRTFAVTDELVFKDA 547
              L +  G I +  + +  + S      KE +++ G+L       D+     D  + ++ 
Sbjct: 1504 EELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQ 1563

Query: 548  KKDDAVRKAYKYLAALHENCSQLIQTIE--------DTGTIMREVRDLEEQIETELGK-K 598
                +       L  L E+  +L++ IE        ++     + ++L+++ E  L   +
Sbjct: 1564 SLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYE 1623

Query: 599  TLSN-LEKIREDYRALRQENAGLLGRVR 625
             +SN  E+I+    A+RQE   L G++R
Sbjct: 1624 NVSNEAERIQHVVEAVRQEKQELYGKLR 1651



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 63/297 (21%), Positives = 134/297 (45%), Gaps = 34/297 (11%)

Query: 328  AAQEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHSKLSTAEREQALRLKS 387
            A  E EL+SL++QL  ++ S+E+ +     L     Q E++ ++SK S  + E  L+   
Sbjct: 2308 AKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASR 2367

Query: 388  RAVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQDCRELESS 447
                         ++L   +    Q++I L    E+     +AE R     Q  +E++  
Sbjct: 2368 ELT----------SRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQ----QHDKEIKEL 2413

Query: 448  RRLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRD-VSRLAYTQRILEIVGNIRK 506
              L   +E    V    EE ++  +   QLM  L+T+ ++ + + A     ++ + +++ 
Sbjct: 2414 ENLLSQEEEENIV--LEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQN 2471

Query: 507  QKEEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYKYLAALH-E 565
             ++   +I+ D ++L++   S+  + D+   +  E   ++ K  + +R    ++  L+ E
Sbjct: 2472 DRD---RIVGDYQQLEERHLSIILEKDQ---LIQEAAAENNKLKEEIRGLRSHMDDLNSE 2525

Query: 566  NC---SQLIQTIEDTGTIM-------REVRDLEEQIETELGKKTLSNLEKIREDYRA 612
            N    ++LIQ  ED   ++       +++ +++ Q   EL  K     EK++E   A
Sbjct: 2526 NAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEA 2582



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 60/290 (20%), Positives = 135/290 (46%), Gaps = 34/290 (11%)

Query: 331  EQELESLREQLEGVNRSIEEVEADMKT--------LG-VSFVQAESECRHSKLSTAERE- 380
            ++EL   R  +E + +S+ +VE+ +          LG ++ +Q E +   +++  +  E 
Sbjct: 1503 QEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLEN 1562

Query: 381  QALRLKSRAVELLPDG-TANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQ 439
            Q+L     +++L  +G T +  KL   +E+     I  + +W++    L  EY  L +  
Sbjct: 1563 QSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSY 1622

Query: 440  DCRELESSRRLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRLAYTQRILE 499
            +    E+ R    IQ + ++VR      + K+E+Y +L S       + ++    +++ E
Sbjct: 1623 ENVSNEAER----IQHVVEAVR------QEKQELYGKLRST------EANKKETEKQLQE 1666

Query: 500  IVGNIRKQKEEITKILSDTK----ELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRK 555
                + + KE++ K     +    EL++E + L  ++        E +      + ++++
Sbjct: 1667 AEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKE 1726

Query: 556  AYKYLAALHENCSQLIQTI-EDTGTIMREVRDLEEQIETELGKKTLSNLE 604
              + +   +E  S+  Q++  +  ++  EV+DL+ QIE  + K+  +NLE
Sbjct: 1727 ELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQ--ANLE 1774



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 65/288 (22%), Positives = 117/288 (40%), Gaps = 33/288 (11%)

Query: 335  ESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHSKLSTAEREQALRLKSRAVELLP 394
            + ++E+L  V +  E  E +   L    +   +E   S  +  +     ++K+   ELL 
Sbjct: 1899 QQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKN---ELLE 1955

Query: 395  DGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQDCRELESSRRLA-EI 453
                NL K    +E   Q+++      EK +V       +L K+Q  ++   ++  A E+
Sbjct: 1956 SEMKNLKKCVSELEEEKQQLVK-----EKTKVESEIRKEYLEKIQGAQKEPGNKSHAKEL 2010

Query: 454  QELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRLAYTQRILEIVGNIRKQKEEITK 513
            QEL           + K++  KQL  +       +S L  T + LE V    ++  EITK
Sbjct: 2011 QEL----------LKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITK 2060

Query: 514  ILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYKYLAALHENCSQLIQT 573
                         +L+  ++       EL       DD   +A + LA   +   +L   
Sbjct: 2061 ------------ENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSN 2108

Query: 574  IEDTGTIMREV-RDLEEQIETELGKKTLSNLEKIREDYRALRQENAGL 620
             E   + M++   DLE ++E +  +K L   + ++E   ALR+E   L
Sbjct: 2109 KESVKSQMKQKDEDLERRLE-QAEEKHLKEKKNMQEKLDALRREKVHL 2155



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 41/186 (22%), Positives = 82/186 (44%), Gaps = 35/186 (18%)

Query: 445  ESSRRLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRLAYTQRILEIVGNI 504
            E +  L +I +L + +    EE ++ +E  + L +E  TL   +S            G +
Sbjct: 1834 EINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKD---------GEL 1884

Query: 505  RKQKEEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYKYLAALH 564
            +  +EE+TK+    +++Q+E++ ++ KL  T          + +KDD   +    LA L+
Sbjct: 1885 KMLQEEVTKMNLLNQQIQEELSRVT-KLKET---------AEEEKDDLEERLMNQLAELN 1934

Query: 565  ENCSQLIQTIEDTGTIMREVRDLEEQIETELGKKTLSNLEK----IREDYRALRQENAGL 620
             +     Q + D             QI+ EL +  + NL+K    + E+ + L +E   +
Sbjct: 1935 GSIGNYCQDVTDA------------QIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKV 1982

Query: 621  LGRVRE 626
               +R+
Sbjct: 1983 ESEIRK 1988



 Score = 37.4 bits (85), Expect = 0.042
 Identities = 58/303 (19%), Positives = 127/303 (41%), Gaps = 23/303 (7%)

Query: 320  RRPEQVTWAAQEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHSKLSTAER 379
            ++PE++    + +  + ++ +L+    S +E   + K+L      A         S A+ 
Sbjct: 1466 QKPEEI--GEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADV 1523

Query: 380  EQALRLKSRAVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQ 439
            E  +  +++  + +      L +L L+ E   + +  +     +++  L +    L+   
Sbjct: 1524 ESQVSAQNKEKDTV------LGRLALLQEERDKLITEMDRSLLENQ-SLSSSCESLKLAL 1576

Query: 440  DCRELESSRRLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRLAY-TQRIL 498
            +    +  + + EI+ L  S  A + E + K   +K+L  E E L +    ++   +RI 
Sbjct: 1577 EGLTEDKEKLVKEIESLKSSKIAESTEWQEK---HKELQKEYEILLQSYENVSNEAERIQ 1633

Query: 499  EIVGNIRKQKEEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYK 558
             +V  +R++K+E+   L  T+  +KE      + ++      E + K AK      K  K
Sbjct: 1634 HVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKS-----KQQK 1688

Query: 559  YLAALHENCSQLIQTIEDTGTIMREVRDLEEQIETELGKKTLSNLEKIREDYRALRQENA 618
             L    EN  +L   +   G   +E   +E  + +    K    LE+++ +Y  L ++  
Sbjct: 1689 ILELEEEN-DRLRAEVHPAGDTAKEC--METLLSSNASMK--EELERVKMEYETLSKKFQ 1743

Query: 619  GLL 621
             L+
Sbjct: 1744 SLM 1746



 Score = 37.0 bits (84), Expect = 0.055
 Identities = 70/314 (22%), Positives = 141/314 (44%), Gaps = 38/314 (12%)

Query: 338 REQLEGVNRSIEEVEADMKTLGVSFVQAESE-CRHSKLSTAEREQALRLKSR---AVELL 393
           + +L  +N+ IEE++A   T+  +  Q+E +  +H K ST E  +  ++K +     EL+
Sbjct: 101 KAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELI 160

Query: 394 PDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQDCRELESSRRLAEI 453
               A L + Q   E  AQ    +  ++   +  L  +   +  LQ   +L  ++     
Sbjct: 161 STLQAQLTQAQ--AEQPAQSSTEME-EFVMMKQQLQEKEEFISTLQ--AQLSQTQAEQAA 215

Query: 454 QELHQSVRAAAE-EARRKEEVYKQLMSELETLPRDVSRLAYTQRILE-----IVGNIR-- 505
           Q++ +   A  E + R  E+   QL+++ +       +L   QR LE     +VG  +  
Sbjct: 216 QQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVV 275

Query: 506 -------KQKEEITKILS-DTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAY 557
                     E+  +ILS   ++++ E N+L   ++ T     +++ +  + + A RK  
Sbjct: 276 DLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVE-TEREESKILLEKMELEVAERKLS 334

Query: 558 KYLAALHENCSQLIQTIEDTGTIMREVRD----LEEQIETELGKKT--LSNLEKIREDYR 611
            +   L E    L++  E  G    E+      LE++ + E+ +KT  + +L+K  ++ +
Sbjct: 335 FH--NLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQ 392

Query: 612 ----ALRQENAGLL 621
               AL+ +N+ LL
Sbjct: 393 SACDALKDQNSKLL 406



 Score = 33.1 bits (74), Expect = 0.79
 Identities = 52/279 (18%), Positives = 114/279 (40%), Gaps = 22/279 (7%)

Query: 331  EQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHSKLSTAEREQALRLKSRAV 390
            + EL+ ++ Q    +  I  +++ ++      ++     RH      E  QAL  K   +
Sbjct: 816  QNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEI 875

Query: 391  ----ELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHL----RKLQDCR 442
                +LL +   ++  LQ  +E   Q+V  ++    +  V L  E   L    + L++  
Sbjct: 876  TKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQL 935

Query: 443  ELESSRRLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPR--DVSRLAYTQRILEI 500
             L S    A+ +++ +    ++   +  +E+        E L    D+ +    QR  ++
Sbjct: 936  NLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKL 995

Query: 501  VGNIRKQKEEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYKYL 560
               +  +KE    +L     L++E+ +L  +  +   +++    +   ++D   K Y   
Sbjct: 996  QAALINRKE----LLQRVSRLEEELANLKDESKKEIPLSE--TERGEVEEDKENKEYSE- 1048

Query: 561  AALHENCSQ----LIQTIEDTGTIMREVR-DLEEQIETE 594
              +   C +    L QTI +    ++ +R DLEE++  E
Sbjct: 1049 KCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAE 1087



 Score = 32.3 bits (72), Expect = 1.3
 Identities = 61/295 (20%), Positives = 120/295 (40%), Gaps = 38/295 (12%)

Query: 306 QAQATQVSDVPATSRRPEQVTWAAQEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQA 365
           QAQ TQ     A + +P Q   + + +E   +++QL+     I  ++A +     S  QA
Sbjct: 164 QAQLTQ-----AQAEQPAQS--STEMEEFVMMKQQLQEKEEFISTLQAQL-----SQTQA 211

Query: 366 ESECRHSKLSTAEREQALRLKSRAVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHR 425
           E   +        RE+  R +++ V L  D    L     V     Q++  L  + E+H 
Sbjct: 212 EQAAQQ-----VVREKDARFETQ-VRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHE 265

Query: 426 VPLLAEYRHLRKLQ------DCRELESSRRLAEIQELHQSVRAAAEEARRKEEVYKQLMS 479
             L+   + +  LQ      + R    S++L +++  H ++R   E  R + ++  + M 
Sbjct: 266 ESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKM- 324

Query: 480 ELETLPRDVSRLAYTQRILEIVGNIRKQKEEITKILSDTKELQKEINSLSGKLDRTF-AV 538
           ELE   R +S             N++++   + +      + Q E+ S    L++   A 
Sbjct: 325 ELEVAERKLS-----------FHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAE 373

Query: 539 TDELVFKDAKKDDAVRKAYKYLAALHENCSQLIQ-TIEDTGTIMREVRDLEEQIE 592
            +E            ++      AL +  S+L+Q   E      + ++ LE+Q++
Sbjct: 374 MEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQ 428



 Score = 30.8 bits (68), Expect = 3.9
 Identities = 62/339 (18%), Positives = 134/339 (39%), Gaps = 58/339 (17%)

Query: 313 SDVPATSRRPEQVTWAAQEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHS 372
           S +PA  +  EQ +   Q +  E +     GV     + + D     +S V    +C   
Sbjct: 630 SSLPAVEK--EQASTEHQSRTSEEISLNDAGVELKSTKQDGDKS---LSAVPDIGQCHQD 684

Query: 373 KLSTAEREQALRLKSRAVEL--------------LPDGTANLAKLQLVVENSAQRVIHLA 418
           +L         RLKS+ +EL              L +    ++ L  ++E   +   + +
Sbjct: 685 ELE--------RLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNS 736

Query: 419 GQW---EKHRVPLLAEYRHLRKLQDCR-----------ELESSRRLA-EIQELH-----Q 458
             +    + R  LL++ + L  + + R           E E  RRL  E Q  H     +
Sbjct: 737 SAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTE 796

Query: 459 SVRAAAEEARRKEEVYKQLMSELETLPRDVSRLAYTQRILEIVGNIRKQKEEITKILSDT 518
            + + + EA+ K+   + L +EL+ +    S  +   R L+    ++ ++ E+ +     
Sbjct: 797 QIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQ--SQLQNKESEVLEGAERV 854

Query: 519 KELQKEINSLSGKLDR---TFAVTDELVFKDAKKDDAVR-----KAYKYLAALHENCSQL 570
           + +  ++  LS  L +        D+L+ +  +  + ++     K  +          ++
Sbjct: 855 RHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKM 914

Query: 571 IQTIEDTGTIMREVRDLEEQIETELGKKTLSNLEKIRED 609
           +Q  E+  ++  E++ L+EQ+   L +   +  E++ ED
Sbjct: 915 VQLNEEKFSLGVEIKTLKEQLNL-LSRAEEAKKEQVEED 952


>gi|46592991 GRIP1 associated protein 1 isoform 1 [Homo sapiens]
          Length = 841

 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 67/312 (21%), Positives = 136/312 (43%), Gaps = 37/312 (11%)

Query: 329 AQEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHSKLSTAEREQALRL--- 385
           A+ QEL  LREQ  G+   +++ +A+ + L        S+ + S  + +   + L+    
Sbjct: 351 AKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQ 410

Query: 386 -KSRAVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLA-EYRHLRKLQDCRE 443
            K +  + L +   +  K + +++  A   +    Q   H+  L A   RH +++   R 
Sbjct: 411 EKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQ---HKEELGAVRLRHEKEVLGVR- 466

Query: 444 LESSRRLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRLA----------- 492
              +R   E++ELH+  +   EE R +    K    ELETL + V  L            
Sbjct: 467 ---ARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKG 523

Query: 493 -YTQRILEIVGNIRKQKEEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDD 551
            + +R+ E   ++++Q++E  + L   +E  +    L GK +    V D+L     ++D 
Sbjct: 524 WFERRLKEAEESLQQQQQEQEEALKQCRE--QHAAELKGKEEELQDVRDQLEQAQEERDC 581

Query: 552 AVRKAYKYLAALHENCSQLI---QTIEDTGTIMREVRDLEEQIETELGKKTLSNLEKIRE 608
            +    K +++L +     +   + +E  G+    ++DL+ Q+  E  +K    L++  +
Sbjct: 582 HL----KTISSLKQEVKDTVDGQRILEKKGS--AALKDLKRQLHLE--RKRADKLQERLQ 633

Query: 609 DYRALRQENAGL 620
           D     +  +GL
Sbjct: 634 DILTNSKSRSGL 645



 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 63/291 (21%), Positives = 121/291 (41%), Gaps = 28/291 (9%)

Query: 324 QVTWAAQEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQAESECRHSKLSTAEREQAL 383
           ++ W  +++E   L EQL+G+  S        K    S +Q E      KL   ++E   
Sbjct: 193 ELKWEMEKEEKRLLWEQLQGLESS--------KQAETSRLQEELAKLSEKLK-KKQESFC 243

Query: 384 RLKSRAVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEYRHLRKLQDCRE 443
           RL++    L  D    + +LQ      A     LA + +K +  L A  + L +L+D R+
Sbjct: 244 RLQTEKETLFNDSRNKIEELQ--QRKEADHKAQLA-RTQKLQQELEAANQSLAELRDQRQ 300

Query: 444 LESSRRLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRLAYTQRILEIVGN 503
            E     A ++ L   V   + +A   +E  + L++E   L   ++ L   Q        
Sbjct: 301 GERLEHAAALRALQDQVSIQSADA---QEQVEGLLAENNALRTSLAALEQIQTAK--TQE 355

Query: 504 IRKQKEEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYKYLAAL 563
           +   +E+ T + ++ ++ Q E   L G+ D   +   E +        A  +  + L  +
Sbjct: 356 LNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESL-------RANSRLLEQLQEI 408

Query: 564 HENCSQLIQTIEDTGTIMREVRDLEEQIETELGKKTLSNLEKIREDYRALR 614
            +   QL Q +++     R+  +  + +  EL  +TL    + +E+  A+R
Sbjct: 409 GQEKEQLTQELQEA----RKSAEKRKAMLDELAMETLQEKSQHKEELGAVR 455



 Score = 37.0 bits (84), Expect = 0.055
 Identities = 48/217 (22%), Positives = 101/217 (46%), Gaps = 49/217 (22%)

Query: 420 QWEKHRVPLLAEYRHLRKLQDCRELESSRRLAEIQELHQSVRAAAEEARRKEEVYKQLMS 479
           +WE  +      +  L+ L+  ++ E+SR   E+ +L       +E+ ++K+E + +L +
Sbjct: 195 KWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKL-------SEKLKKKQESFCRLQT 247

Query: 480 ELETLPRDVSRLAYTQRILEIVGNIRKQKEEITKI-LSDTKELQKEINSLSGKLDRTFAV 538
           E ETL  D SR          +  ++++KE   K  L+ T++LQ+E+ + +  L      
Sbjct: 248 EKETLFND-SR--------NKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAEL--- 295

Query: 539 TDELVFKDAKKDDAVRKAYKYLAALHENCSQLIQTIEDTGTIMREVRDLEEQIETELG-- 596
                     +D    +  ++ AAL        + ++D  +I  +  D +EQ+E  L   
Sbjct: 296 ----------RDQRQGERLEHAAAL--------RALQDQVSI--QSADAQEQVEGLLAEN 335

Query: 597 ---KKTLSNLEKIR----EDYRALRQENAGLLGRVRE 626
              + +L+ LE+I+    ++   LR++  GL   +++
Sbjct: 336 NALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQ 372



 Score = 29.6 bits (65), Expect = 8.7
 Identities = 60/328 (18%), Positives = 123/328 (37%), Gaps = 62/328 (18%)

Query: 306 QAQATQVSDVPATSRRPEQVTWAAQEQELESLREQLEGVNRSIEEVEADMKTLGVSFVQA 365
           Q Q  +  +     R         +E+EL+ +R+QLE                     Q 
Sbjct: 537 QQQQQEQEEALKQCREQHAAELKGKEEELQDVRDQLEQ-------------------AQE 577

Query: 366 ESECRHSKLSTAEREQALRLKSRAVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHR 425
           E +C    +S+ ++E         V+   DG   L K         +R +HL    E+ R
Sbjct: 578 ERDCHLKTISSLKQE---------VKDTVDGQRILEKKGSAALKDLKRQLHL----ERKR 624

Query: 426 VPLLAEYRHLRKLQDCRELESSRRLAE---IQELHQSVRA-AAEEARRKEEVYKQLMSEL 481
              L E     +LQD      SR   E   + E++   R    + +      Y++++ E 
Sbjct: 625 ADKLQE-----RLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREK 679

Query: 482 ETLPRDVSRLAYT-------------QRILEIVGNIRKQKEEITKILSDTKELQKEINSL 528
           E+       L+ +             + + E+   + + ++E   +    K L+    S+
Sbjct: 680 ESSAVPARSLSSSPQAQPPRPAELSDEEVAELFQRLAETQQEKWMLEEKVKHLEVSSASM 739

Query: 529 SGKLDRTFAVTDELVFKDAKKDDAVRKAYKYLAALHENCSQLIQTIEDTGTIMREVRDLE 588
           +  L R  A+ +  V  D++ D +V   +   + L      L++  ++       +R++ 
Sbjct: 740 AEDLCRKSAIIETYVM-DSRIDVSVAAGHTDRSGLGSVLRDLVKPGDE------NLREMN 792

Query: 589 EQIETELGKKTLSNLEKIREDYRALRQE 616
           ++++  L ++   N+  + +D   L QE
Sbjct: 793 KKLQNMLEEQLTKNMH-LHKDMEVLSQE 819


>gi|110611218 ribosome binding protein 1 [Homo sapiens]
          Length = 977

 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 65/288 (22%), Positives = 127/288 (44%), Gaps = 29/288 (10%)

Query: 333 ELESLREQLE-GVNRSIEEVEADMKTLGVSFVQAESECRHSKLSTAEREQALRLKSRAVE 391
           ++ +L+EQLE G N  +  ++ +   L  +  QA S+         E +Q   L     E
Sbjct: 346 KIRTLQEQLENGPNTQLARLQQENSILRDALNQATSQ--------VESKQNAELAKLRQE 397

Query: 392 LLPDGTANLAKLQLVVENSAQR--VIHLAGQWEKHRVPLLAEYRHLRKLQDCRELESSRR 449
           L       + K + V ++  QR  +   A  +EK  + L A +R   +    R  E SR 
Sbjct: 398 LSKVSKELVEKSEAVRQDEQQRKALEAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRE 457

Query: 450 LAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRLAYTQRILEIVGNIRKQKE 509
           L   Q  H S+RA AE+A+ +++   +L S+L++   +V                R + E
Sbjct: 458 LCHTQSSHASLRADAEKAQEQQQQMAELHSKLQSSEAEV----------------RSKCE 501

Query: 510 EITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVR-KAYKYLAALHENCS 568
           E++ +    +E + E + L+ ++    A+ +    +DA+   A + +A +    L E  S
Sbjct: 502 ELSGLHGQLQEARAENSQLTERIRSIEALLEAGQARDAQDVQASQAEADQQQTRLKELES 561

Query: 569 QLIQTIEDTGTIMREVRDLEEQIETELGKKTLSNLEKIREDYRALRQE 616
           Q +  +E     +RE  + ++    +L +K    +E +    +A +++
Sbjct: 562 Q-VSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEALATAEQACKEK 608



 Score = 36.2 bits (82), Expect = 0.093
 Identities = 51/262 (19%), Positives = 103/262 (39%), Gaps = 29/262 (11%)

Query: 373 KLSTAEREQALRLKSRAVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEY 432
           KL   E+E A   KS+  EL  +  A  AK               AG+  K +  L+A  
Sbjct: 274 KLLATEQEDAAVAKSKLRELNKEMAAEKAKAA-------------AGE-AKVKKQLVARE 319

Query: 433 RHLRKLQDCRELESSRRLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRLA 492
           + +  +Q   +      + E+Q+L   +R   E+           + +  ++ RD    A
Sbjct: 320 QEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRDALNQA 379

Query: 493 YTQRILEIVGNIRKQKEEITKILSDTKELQKEI-------NSLSGKLDRTFAVTDELVFK 545
            +Q   +    + K ++E++K+  +  E  + +        +L  K         +L   
Sbjct: 380 TSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAAAFEKQVLQLQAS 439

Query: 546 DAKKDDAVRKAYKYLAALHENCSQLIQTIEDTGTIMREVRDLEEQIETELGKKTLSNLEK 605
             + ++A++K       L E   +L  T     ++  +    +EQ   +   +  S L+ 
Sbjct: 440 HRESEEALQK------RLDEVSRELCHTQSSHASLRADAEKAQEQ--QQQMAELHSKLQS 491

Query: 606 IREDYRALRQENAGLLGRVREA 627
              + R+  +E +GL G+++EA
Sbjct: 492 SEAEVRSKCEELSGLHGQLQEA 513



 Score = 31.6 bits (70), Expect = 2.3
 Identities = 85/383 (22%), Positives = 150/383 (39%), Gaps = 41/383 (10%)

Query: 251 QLTEHLRQSWGLLGAPIQARDLGELLQAWGAGAKTGAPKGSRFTHSEKFTFHLEPQA--- 307
           QLTE +R    LL A  QARD  ++ QA  A A     + +R    E     LE +A   
Sbjct: 519 QLTERIRSIEALLEAG-QARDAQDV-QASQAEADQ---QQTRLKELESQVSGLEKEAIEL 573

Query: 308 -QATQVSDVPATSRRPEQVTWAAQEQEL---ESLREQLEGVNRSIEEVEADMKTLGVSFV 363
            +A +   V     R +   W A E      ++ +E+L  + ++ EE E  +  +    +
Sbjct: 574 REAVEQQKVKNNDLREKN--WKAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTM 631

Query: 364 QAESECRHSKLSTAER---EQALRLKSRAVELL---PDGTANLAKLQLVVENSAQRVIHL 417
           +A           A++   E    LK +   LL   P      + L   +  + +    L
Sbjct: 632 EALLALLPELSVLAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTL 691

Query: 418 AGQWEKHRVPLLAEYRHLRKLQDCRELESSRRLAEIQELHQSVRAAAEEARRKEEVYKQL 477
             + +++R  L      LR LQ   E E     A++    + ++ +    +  EE+ ++L
Sbjct: 692 QAECDQYRSILAETEGMLRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKL 751

Query: 478 MSELETLPRDVSRLAYTQRILEIVGNIRKQKEEITKILSDTKELQKEINSLSGKLDRTFA 537
             ELE+          + ++ E   ++  + E+   + + + E Q     ++G       
Sbjct: 752 KGELES----------SDQVREHTSHLEAELEK--HMAAASAECQNYAKEVAGLRQLLLE 799

Query: 538 VTDELVFKDAKKDDAVRKAYKYLAALHENCSQLIQTIEDTGTIMREVRDLE----EQIET 593
              +L   DA K +A +K    LA + +  S++   +ED           E    EQ   
Sbjct: 800 SQSQL---DAAKSEA-QKQSDELALVRQQLSEMKSHVEDGDIAGAPASSPEAPPAEQDPV 855

Query: 594 ELGKKTLSNLEKIREDYRALRQE 616
           +L K  L   E I ED +  RQ+
Sbjct: 856 QL-KTQLEWTEAILEDEQTQRQK 877


>gi|110611220 ribosome binding protein 1 [Homo sapiens]
          Length = 977

 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 65/288 (22%), Positives = 127/288 (44%), Gaps = 29/288 (10%)

Query: 333 ELESLREQLE-GVNRSIEEVEADMKTLGVSFVQAESECRHSKLSTAEREQALRLKSRAVE 391
           ++ +L+EQLE G N  +  ++ +   L  +  QA S+         E +Q   L     E
Sbjct: 346 KIRTLQEQLENGPNTQLARLQQENSILRDALNQATSQ--------VESKQNAELAKLRQE 397

Query: 392 LLPDGTANLAKLQLVVENSAQR--VIHLAGQWEKHRVPLLAEYRHLRKLQDCRELESSRR 449
           L       + K + V ++  QR  +   A  +EK  + L A +R   +    R  E SR 
Sbjct: 398 LSKVSKELVEKSEAVRQDEQQRKALEAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRE 457

Query: 450 LAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRLAYTQRILEIVGNIRKQKE 509
           L   Q  H S+RA AE+A+ +++   +L S+L++   +V                R + E
Sbjct: 458 LCHTQSSHASLRADAEKAQEQQQQMAELHSKLQSSEAEV----------------RSKCE 501

Query: 510 EITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVR-KAYKYLAALHENCS 568
           E++ +    +E + E + L+ ++    A+ +    +DA+   A + +A +    L E  S
Sbjct: 502 ELSGLHGQLQEARAENSQLTERIRSIEALLEAGQARDAQDVQASQAEADQQQTRLKELES 561

Query: 569 QLIQTIEDTGTIMREVRDLEEQIETELGKKTLSNLEKIREDYRALRQE 616
           Q +  +E     +RE  + ++    +L +K    +E +    +A +++
Sbjct: 562 Q-VSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEALATAEQACKEK 608



 Score = 36.2 bits (82), Expect = 0.093
 Identities = 51/262 (19%), Positives = 103/262 (39%), Gaps = 29/262 (11%)

Query: 373 KLSTAEREQALRLKSRAVELLPDGTANLAKLQLVVENSAQRVIHLAGQWEKHRVPLLAEY 432
           KL   E+E A   KS+  EL  +  A  AK               AG+  K +  L+A  
Sbjct: 274 KLLATEQEDAAVAKSKLRELNKEMAAEKAKAA-------------AGE-AKVKKQLVARE 319

Query: 433 RHLRKLQDCRELESSRRLAEIQELHQSVRAAAEEARRKEEVYKQLMSELETLPRDVSRLA 492
           + +  +Q   +      + E+Q+L   +R   E+           + +  ++ RD    A
Sbjct: 320 QEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRDALNQA 379

Query: 493 YTQRILEIVGNIRKQKEEITKILSDTKELQKEI-------NSLSGKLDRTFAVTDELVFK 545
            +Q   +    + K ++E++K+  +  E  + +        +L  K         +L   
Sbjct: 380 TSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAAAFEKQVLQLQAS 439

Query: 546 DAKKDDAVRKAYKYLAALHENCSQLIQTIEDTGTIMREVRDLEEQIETELGKKTLSNLEK 605
             + ++A++K       L E   +L  T     ++  +    +EQ   +   +  S L+ 
Sbjct: 440 HRESEEALQK------RLDEVSRELCHTQSSHASLRADAEKAQEQ--QQQMAELHSKLQS 491

Query: 606 IREDYRALRQENAGLLGRVREA 627
              + R+  +E +GL G+++EA
Sbjct: 492 SEAEVRSKCEELSGLHGQLQEA 513



 Score = 31.6 bits (70), Expect = 2.3
 Identities = 85/383 (22%), Positives = 150/383 (39%), Gaps = 41/383 (10%)

Query: 251 QLTEHLRQSWGLLGAPIQARDLGELLQAWGAGAKTGAPKGSRFTHSEKFTFHLEPQA--- 307
           QLTE +R    LL A  QARD  ++ QA  A A     + +R    E     LE +A   
Sbjct: 519 QLTERIRSIEALLEAG-QARDAQDV-QASQAEADQ---QQTRLKELESQVSGLEKEAIEL 573

Query: 308 -QATQVSDVPATSRRPEQVTWAAQEQEL---ESLREQLEGVNRSIEEVEADMKTLGVSFV 363
            +A +   V     R +   W A E      ++ +E+L  + ++ EE E  +  +    +
Sbjct: 574 REAVEQQKVKNNDLREKN--WKAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTM 631

Query: 364 QAESECRHSKLSTAER---EQALRLKSRAVELL---PDGTANLAKLQLVVENSAQRVIHL 417
           +A           A++   E    LK +   LL   P      + L   +  + +    L
Sbjct: 632 EALLALLPELSVLAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTL 691

Query: 418 AGQWEKHRVPLLAEYRHLRKLQDCRELESSRRLAEIQELHQSVRAAAEEARRKEEVYKQL 477
             + +++R  L      LR LQ   E E     A++    + ++ +    +  EE+ ++L
Sbjct: 692 QAECDQYRSILAETEGMLRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKL 751

Query: 478 MSELETLPRDVSRLAYTQRILEIVGNIRKQKEEITKILSDTKELQKEINSLSGKLDRTFA 537
             ELE+          + ++ E   ++  + E+   + + + E Q     ++G       
Sbjct: 752 KGELES----------SDQVREHTSHLEAELEK--HMAAASAECQNYAKEVAGLRQLLLE 799

Query: 538 VTDELVFKDAKKDDAVRKAYKYLAALHENCSQLIQTIEDTGTIMREVRDLE----EQIET 593
              +L   DA K +A +K    LA + +  S++   +ED           E    EQ   
Sbjct: 800 SQSQL---DAAKSEA-QKQSDELALVRQQLSEMKSHVEDGDIAGAPASSPEAPPAEQDPV 855

Query: 594 ELGKKTLSNLEKIREDYRALRQE 616
           +L K  L   E I ED +  RQ+
Sbjct: 856 QL-KTQLEWTEAILEDEQTQRQK 877


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.131    0.370 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,075,022
Number of Sequences: 37866
Number of extensions: 1099608
Number of successful extensions: 7010
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 42
Number of HSP's successfully gapped in prelim test: 594
Number of HSP's that attempted gapping in prelim test: 5395
Number of HSP's gapped (non-prelim): 1732
length of query: 627
length of database: 18,247,518
effective HSP length: 108
effective length of query: 519
effective length of database: 14,157,990
effective search space: 7347996810
effective search space used: 7347996810
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.