Guide to the Human Genome
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Search of human proteins with 7661690

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|7661690 coiled-coil domain containing 9 [Homo sapiens]
         (531 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|7661690 coiled-coil domain containing 9 [Homo sapiens]            1105   0.0  
gi|155029552 hypothetical protein LOC388115 [Homo sapiens]             74   3e-13
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom...    72   1e-12
gi|55741709 RNA binding motif protein 25 [Homo sapiens]                67   3e-11
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]     67   3e-11
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof...    67   3e-11
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof...    66   7e-11
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof...    65   2e-10
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof...    65   2e-10
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]     64   4e-10
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof...    62   1e-09
gi|4503509 eukaryotic translation initiation factor 3, subunit 1...    59   8e-09
gi|50962882 G patch domain containing 8 [Homo sapiens]                 59   8e-09
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi...    58   2e-08
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]      57   5e-08
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li...    55   1e-07
gi|17975763 myelin transcription factor 1 [Homo sapiens]               55   1e-07
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]              55   2e-07
gi|55956788 nucleolin [Homo sapiens]                                   55   2e-07
gi|155030232 proline, glutamic acid and leucine rich protein 1 [...    54   3e-07
gi|100816397 MYST histone acetyltransferase (monocytic leukemia)...    54   4e-07
gi|30795231 brain abundant, membrane attached signal protein 1 [...    54   5e-07
gi|221316599 chromogranin B precursor [Homo sapiens]                   54   5e-07
gi|60498973 myelin transcription factor 1-like [Homo sapiens]          54   5e-07
gi|78042577 MAP7 domain containing 1 [Homo sapiens]                    54   5e-07
gi|33286446 opioid growth factor receptor [Homo sapiens]               53   6e-07
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li...    53   8e-07
gi|148746195 trichohyalin [Homo sapiens]                               53   8e-07
gi|62244004 modulator of estrogen induced transcription isoform ...    53   8e-07
gi|63176611 modulator of estrogen induced transcription isoform ...    53   8e-07

>gi|7661690 coiled-coil domain containing 9 [Homo sapiens]
          Length = 531

 Score = 1105 bits (2857), Expect = 0.0
 Identities = 531/531 (100%), Positives = 531/531 (100%)

Query: 1   MAATLDLKSKEEKDAELDKRIEALRRKNEALIRRYQEIEEDRKKAELEGVAVTAPRKGRS 60
           MAATLDLKSKEEKDAELDKRIEALRRKNEALIRRYQEIEEDRKKAELEGVAVTAPRKGRS
Sbjct: 1   MAATLDLKSKEEKDAELDKRIEALRRKNEALIRRYQEIEEDRKKAELEGVAVTAPRKGRS 60

Query: 61  VEKENVAVESEKNLGPSRRSPGTPRPPGASKGGRTPPQQGGRAGMGRASRSWEGSPGEQP 120
           VEKENVAVESEKNLGPSRRSPGTPRPPGASKGGRTPPQQGGRAGMGRASRSWEGSPGEQP
Sbjct: 61  VEKENVAVESEKNLGPSRRSPGTPRPPGASKGGRTPPQQGGRAGMGRASRSWEGSPGEQP 120

Query: 121 RGGGAGGRGRRGRGRGSPHLSGAGDTSISDRKSKEWEERRRQNIEKMNEEMEKIAEYERN 180
           RGGGAGGRGRRGRGRGSPHLSGAGDTSISDRKSKEWEERRRQNIEKMNEEMEKIAEYERN
Sbjct: 121 RGGGAGGRGRRGRGRGSPHLSGAGDTSISDRKSKEWEERRRQNIEKMNEEMEKIAEYERN 180

Query: 181 QREGVLEPNPVRNFLDDPRRRSGPLEESERDRREESRRHGRNWGGPDFERVRCGLEHERQ 240
           QREGVLEPNPVRNFLDDPRRRSGPLEESERDRREESRRHGRNWGGPDFERVRCGLEHERQ
Sbjct: 181 QREGVLEPNPVRNFLDDPRRRSGPLEESERDRREESRRHGRNWGGPDFERVRCGLEHERQ 240

Query: 241 GRRAGLGSAGDMTLSMTGRERSEYLRWKQEREKIDQERLQRHRKPTGQWRREWDAEKTDG 300
           GRRAGLGSAGDMTLSMTGRERSEYLRWKQEREKIDQERLQRHRKPTGQWRREWDAEKTDG
Sbjct: 241 GRRAGLGSAGDMTLSMTGRERSEYLRWKQEREKIDQERLQRHRKPTGQWRREWDAEKTDG 300

Query: 301 MFKDGPVPAHEPSHRYDDQAWARPPKPPTFGEFLSQHKAEASSRRRRKSSRPQAKAAPRA 360
           MFKDGPVPAHEPSHRYDDQAWARPPKPPTFGEFLSQHKAEASSRRRRKSSRPQAKAAPRA
Sbjct: 301 MFKDGPVPAHEPSHRYDDQAWARPPKPPTFGEFLSQHKAEASSRRRRKSSRPQAKAAPRA 360

Query: 361 YSDHDDRWETKEGAASPAPETPQPTSPETSPKETPMQPPEIPAPAHRPPEDEGEENEGEE 420
           YSDHDDRWETKEGAASPAPETPQPTSPETSPKETPMQPPEIPAPAHRPPEDEGEENEGEE
Sbjct: 361 YSDHDDRWETKEGAASPAPETPQPTSPETSPKETPMQPPEIPAPAHRPPEDEGEENEGEE 420

Query: 421 DEEWEDISEDEEEEEIEVEEGDEEEPAQDHQAPEAAPTGIPCSEQAHGVPFSPEEPLLEP 480
           DEEWEDISEDEEEEEIEVEEGDEEEPAQDHQAPEAAPTGIPCSEQAHGVPFSPEEPLLEP
Sbjct: 421 DEEWEDISEDEEEEEIEVEEGDEEEPAQDHQAPEAAPTGIPCSEQAHGVPFSPEEPLLEP 480

Query: 481 QAPGTPSSPFSPPSGHQPVSDWGEEVELNSPRTTHLAGALSPGEAWPFESV 531
           QAPGTPSSPFSPPSGHQPVSDWGEEVELNSPRTTHLAGALSPGEAWPFESV
Sbjct: 481 QAPGTPSSPFSPPSGHQPVSDWGEEVELNSPRTTHLAGALSPGEAWPFESV 531


>gi|155029552 hypothetical protein LOC388115 [Homo sapiens]
          Length = 534

 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 81/279 (29%), Positives = 107/279 (38%), Gaps = 40/279 (14%)

Query: 263 EYLRWKQEREKIDQERLQRHRKPTGQWRREWDAEKTDGMFKD-----GPVPAHEPSHR-- 315
           +Y +WKQERE+ID  RL RHR   G WRR WD +K     +D     G  PA   S R  
Sbjct: 234 DYAQWKQEREQIDLARLARHRDAQGDWRRPWDLDKAKSTLQDCSQLRGEGPARAGSRRGP 293

Query: 316 YDDQAWARPPKPP----TFGEFLSQHKAEASSRRRRKSSRPQAKAAPRAYSDHDDRWETK 371
              Q    PP  P      G+      A A+  + R   R   +A      +  +  E +
Sbjct: 294 RSHQKLQPPPLLPDGKGRGGQASRPSVAPATGSKARGKERLTGRARRWDMKEDKEELEGQ 353

Query: 372 EGAASPAPETPQPTSPETSPKETPMQPPEI-PAPAHRPPEDEGEENEGEEDEEWEDISED 430
           EG+ S   ET  P+  E + K++ M+   +  APA  P     E  +GE           
Sbjct: 354 EGSQS-TRET--PSEEEQAQKQSGMEQGRLGSAPAASPALASPEGPKGE----------- 399

Query: 431 EEEEEIEVEEGDEEEPAQDHQAPEAAPTGIPCSEQAHGVPFSPEEPLLEPQAPGTPSSPF 490
                  V       P    Q P+ AP  +  S    G+P   E   +    PG   SP 
Sbjct: 400 ------SVASTASSVPCSP-QEPDLAP--LDLSLGGAGIPGPRESGCVLGLRPGAQESPV 450

Query: 491 SPPSG--HQPVSDWGEEVEL---NSPRTTHLAGALSPGE 524
           S P G   QP+     + EL     P     AG   PGE
Sbjct: 451 SWPEGSKQQPLGWSNHQAELEVQTCPEPQRGAGLPEPGE 489



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 33/47 (70%), Positives = 43/47 (91%)

Query: 9   SKEEKDAELDKRIEALRRKNEALIRRYQEIEEDRKKAELEGVAVTAP 55
           S++EKDAELD+RI ALR+KN+AL+RRYQEI+EDR++AE  G+AVT P
Sbjct: 58  SRQEKDAELDRRIVALRKKNQALLRRYQEIQEDRRQAEQGGMAVTTP 104


>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
            sapiens]
          Length = 1152

 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 100/452 (22%), Positives = 164/452 (36%), Gaps = 35/452 (7%)

Query: 14   DAELDKRIEALRRKNEALIRRYQEIEEDRKKAELEGVAVTAPRKGRSVEKENVAVESEKN 73
            +A  D+ +E    K  A   +   IEE   +A  E V V   RK      E   + S+  
Sbjct: 577  EAFSDEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRK------EKTEILSDDL 630

Query: 74   LGPSRRSPGTPRPPGASKGGRTPPQQGGRAGMGRASRSWEGSPGEQPRGGGAGGRGRRGR 133
               +  S G  +  G ++ G      G        +  W+    E+ +G    GRG   R
Sbjct: 631  TDKAEVSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDE--EREKGEKDKGRGEMER 688

Query: 134  -GRGSPHLSGAGDTSISDRKSKEWEERRRQNIEKMNEEMEKIAEYERNQREGVLEPNPVR 192
             G G   L+   +    D + +E +ER + + ++ N+EME+  E E  + E         
Sbjct: 689  PGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEE 748

Query: 193  NFLDDPRRRSGPLEESERDR------REESRRHGRNWGGPDFERVRCGLEHERQGR---- 242
               +   +  G  EE E +R      R++  R G+   G +      G E E +GR    
Sbjct: 749  EEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEK 808

Query: 243  -RAGLGSAGDMTLSMTGRERSEYLRWKQEREKIDQERLQRHRKPTGQWRREWDAEKTDGM 301
               G    G++      RE  E     +E E   +E      +  G+ + E + E+ +G 
Sbjct: 809  EEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGE 868

Query: 302  FK----DGPVPAHEPSHRYDDQAWARPPKPPTFGEFLSQHKAEASSRRRRKSSRPQAKAA 357
             +    +G     E     +++      +    GE   + + E            + +  
Sbjct: 869  EEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEG 928

Query: 358  PRAYSDHDDRWETKEGAASPAPETPQPTSPETSPKETPMQPPEIPAPAHRPPEDEGEENE 417
                 + +   E ++G      E  +    E           E         E EGEE E
Sbjct: 929  EGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEE----------EGEGEGEEEGEGEGEEGE 978

Query: 418  GE-EDEEWEDISEDEEEEEIEVEEGDEEEPAQ 448
            GE E+EE E   E+EE EE   EEG+ EE  +
Sbjct: 979  GEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGE 1010



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 98/445 (22%), Positives = 146/445 (32%), Gaps = 62/445 (13%)

Query: 6    DLKSKEEKDAELDKRIEALRRKNEALIRRYQEIEEDRKKAELEGVAVTAPRKGRSVEKEN 65
            +L  KEE      +  E   R+      R QE+EE  ++   EG      R+    EKE 
Sbjct: 695  ELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEE-EKEG 753

Query: 66   VAVES---EKNLGPSRRSPGTPRPPGASKGGRTPPQQGGRAGMGRASRSWEGSPGEQPRG 122
               E    E+  G   +  G  R      G     ++ G  G G    + EG   E+  G
Sbjct: 754  EGKEEGEGEEVEGEREKEEGE-RKKEERAGKEEKGEEEGDQGEGEEEET-EGRGEEKEEG 811

Query: 123  GGA-GGRGRRGRG-RGSPHLSGAGDTSISDRKSKEWEERRRQNIEKMNEEMEKIAEYERN 180
            G   GG    G+G R      G G+    + + +E E    +   K  EE E+  E E  
Sbjct: 812  GEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEE-GEGEEE 870

Query: 181  QREGVLEPNPVRNFLDDPRRRSGPLEESERDRREESRRHGRNWGGPDFERVRCGLEHERQ 240
              EG  E               G  EE E +  EE    G    G            E +
Sbjct: 871  GEEGEGE---------------GEEEEGEGEGEEEGEGEGEEEEG------------EGE 903

Query: 241  GRRAGLGSAGDMTLSMTGRERSEYLRWKQEREKIDQERLQRHRKPTGQWRREWDAEKTDG 300
            G   G G   +      G E  E    + E E+ + E         G+   E +  + +G
Sbjct: 904  GEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEG------EDGEGEGEEEEGEWEG 957

Query: 301  MFKDGPVPAHEPSHRYDDQAWARPPKPPTFGEFLSQHKAEASSRRRRKSSRPQAKAAPRA 360
              ++G     E      ++      +    GE   +   E            + +     
Sbjct: 958  EEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEE 1017

Query: 361  YSDHDDRWETKEGAASPAPETPQPTSPETSPKETPMQPPEIPAPAHRPPEDEGEEN--EG 418
              + +   E +EG      E  +    E                  R  E EGEEN    
Sbjct: 1018 EGEVEGEVEGEEGEGEGEEEEGEEEGEE------------------REKEGEGEENRRNR 1059

Query: 419  EEDEEWEDISEDEEEEEIEVEEGDE 443
            EE+EE E   ++  EEE E ++G+E
Sbjct: 1060 EEEEEEEGKYQETGEEENERQDGEE 1084


>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
          Length = 843

 Score = 67.4 bits (163), Expect = 3e-11
 Identities = 93/406 (22%), Positives = 150/406 (36%), Gaps = 21/406 (5%)

Query: 137 SPHLSGAGDTSISDRKSKEWEERRRQNIEKMNEEMEKIAEYERNQREGVLEPNPVRNFLD 196
           S  +S   DT     + K  +E+ RQ IEK   E E+  E ER +RE   E    R    
Sbjct: 278 SREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERREREREREREREREK 337

Query: 197 DPRRRSGPLEESERDRREESRRHGRNWGGPDFERVRCGLEHERQGRRAGLGSAGDMTLSM 256
           +  R      + +RDR +E  R        D +R R   +  +   R+   S        
Sbjct: 338 EKERERERERDRDRDRTKERDRDRDRERDRDRDRERSS-DRNKDRSRSREKSRDRERERE 396

Query: 257 TGRERSEYLRWKQEREKIDQERLQRHRKPTGQWRREWDAEKTDGMFK---DGPVPAHEPS 313
             RER      ++ERE+  +   +R R+     +R+ + ++ D   +   +  +   E +
Sbjct: 397 REREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAA 456

Query: 314 HRYDDQAWARPPKPPTFGEFLSQHKAEASSRRRRKSSRPQAKAAPRAYSDHDDRWETKEG 373
           ++   + W    +  T  E+  + + E   RR       + K     Y D  D  +   G
Sbjct: 457 YQERLKNWEIRERKKT-REYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRG 515

Query: 374 AASPAPETPQPTSPETSPKETPMQPPEIP-------APAHRPPEDEGEENEGEEDE---- 422
           +A       +    E   ++   +  E+        A  H  P+ E +  E E +     
Sbjct: 516 SALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQP 575

Query: 423 --EWEDISEDEEEEEIEVEEGDEEEPAQDHQAPEAAPTGIPCSEQAHGVP-FSPEEPLLE 479
             + E  SE+EEEE+ E EE   EEP ++ + PE  P   P        P  S       
Sbjct: 576 QIKQEPESEEEEEEKQEKEE-KREEPMEEEEEPEQKPCLKPTLRPISSAPSVSSASGNAT 634

Query: 480 PQAPGTPS-SPFSPPSGHQPVSDWGEEVELNSPRTTHLAGALSPGE 524
           P  PG  S      P  + P     EE       +  L  + SPG+
Sbjct: 635 PNTPGDESPCGIIIPHENSPDQQQPEEHRPKIGLSLKLGASNSPGQ 680


>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
          Length = 770

 Score = 67.4 bits (163), Expect = 3e-11
 Identities = 102/406 (25%), Positives = 153/406 (37%), Gaps = 76/406 (18%)

Query: 157 EERRRQNIEKMNEEMEKIAEYERNQREGVLEPNPVRNFLDDPRRRSGPL--EESERDRRE 214
           E++RR+  E+  E        +R+ +   LE   +R+   +   R+ P   E+S  DR E
Sbjct: 19  EKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDRGE 78

Query: 215 ESRRHGRNWGGPDFERVRCGLEHERQGRRAGLGSAGDMTLSMTGRERSEYLRWKQEREKI 274
           E          P  +  R    H R+  +                 R E  +WK  R K 
Sbjct: 79  EDDSLAIK---PPQQMSRKEKVHHRKDEK-----------------RKE--KWKHARVKE 116

Query: 275 -DQERLQRHRKPTGQWRREWDAEKTDGMFKDGPVPAHEPSHRYDDQAWARPPKPPTFGEF 333
            + ER +RHR+   + RREW+ +K   M       A E S R  D+      K     + 
Sbjct: 117 REHERRKRHREEQDKARREWERQKRREM-------AREHSRRERDRLEQLERKRERERKM 169

Query: 334 LSQHKA--EASSRRRRKSSRPQAKAAPRAYS--------DHDDRWETKEGAASPAPETPQ 383
             Q K   E   R RR   R + + A R  S        D+ D+ +    + SP P  P+
Sbjct: 170 REQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSP-PRPPR 228

Query: 384 PT----SPETSPKETPMQPPEI------------------PAPAHRPPEDEGEENEGEED 421
                       KE  M+  ++                   + A      E EE E EE+
Sbjct: 229 ERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEE 288

Query: 422 EEWEDISEDEEEEEIEVEEGDEEEPAQDHQAPEAAPTGIPCSEQAHGVPFSPEEPLLEPQ 481
           EE    SE+ EEEE E EE +EE  +   +A E +   +   E +       E  LL   
Sbjct: 289 EEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLV-- 346

Query: 482 APGTPSSPFSPPSGHQPVSDWGEEVELNSPRTTHLAGALSPGEAWP 527
               P S F   SG    ++  EEV   +P+++    AL+ G+  P
Sbjct: 347 ---VPESRFDRDSGESEEAE--EEVGEGTPQSS----ALTEGDYVP 383



 Score = 60.1 bits (144), Expect = 5e-09
 Identities = 87/355 (24%), Positives = 140/355 (39%), Gaps = 65/355 (18%)

Query: 159 RRRQNIEKMNEEMEKIAEYERNQREGVLEPNPVRNFLDDPRR---RSGPLEESERDRREE 215
           RR  ++E   EE + +A     Q         V +  D+ R+   +   ++E E +RR+ 
Sbjct: 68  RREDSMEDRGEEDDSLAIKPPQQMS---RKEKVHHRKDEKRKEKWKHARVKEREHERRKR 124

Query: 216 SRRHGRNWGGPDFERVRCGLEHERQGRRAGLGSAGDMTLSMTGRERS--EYLRWKQEREK 273
            R           E+ +   E ERQ RR       +M    + RER   E L  K+ERE+
Sbjct: 125 HRE----------EQDKARREWERQKRR-------EMAREHSRRERDRLEQLERKRERER 167

Query: 274 IDQERLQRHRKPTGQWRREWDAEKTDGMFKDGPVPAHEPSHR--YDDQA----WAR-PPK 326
             +E+ +  R+   + RR  +  K     ++  V AH  + R  Y D+     W+R PP+
Sbjct: 168 KMREQQKEQREQKERERRAEERRKEREARRE--VSAHHRTMREDYSDKVKASHWSRSPPR 225

Query: 327 PPT----FGEFLSQHKAEASSRR------------RRKSSRPQAKAAPRAYSDHDDRWET 370
           PP      G+     K E    R             RK+S  ++ +A       ++  E 
Sbjct: 226 PPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEE 285

Query: 371 KEGAASPAPETPQPTSPETSPKETPMQPPEIPAPAHRPPEDEGEENEGEEDEEWEDISED 430
           +E       E    TS E+  +E   +  E    ++    +E  E   EE  E E++SED
Sbjct: 286 EE------EEEEGSTSEESEEEEEEEEEEEEETGSN---SEEASEQSAEEVSE-EEMSED 335

Query: 431 EEEEE-----IEVEEGDEEEPAQDHQAPEAAPTGIPCSEQAHGVPFSPEEPLLEP 480
           EE E      +  E   + +  +  +A E    G P S       + P+ P L P
Sbjct: 336 EERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALLP 390


>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           9 [Homo sapiens]
          Length = 771

 Score = 67.4 bits (163), Expect = 3e-11
 Identities = 99/405 (24%), Positives = 154/405 (38%), Gaps = 73/405 (18%)

Query: 157 EERRRQNIEKMNEEMEKIAEYERNQREGVLEPNPVRNFLDDPRRRSGPL--EESERDRRE 214
           E++RR+  E+  E        +R+ +   LE   +R+   +   R+ P   E+S  DR E
Sbjct: 19  EKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDRGE 78

Query: 215 ESRRHGRNWGGPDFERVRCGLEHERQGRRAGLGSAGDMTLSMTGRERSEYLRWKQEREKI 274
           E          P  +  R    H R+  +               R+  ++ R K++    
Sbjct: 79  EDDSLAIK---PPQQMSRKEKVHHRKDEK---------------RKEKKHARVKEKER-- 118

Query: 275 DQERLQRHRKPTGQWRREWDAEKTDGMFKDGPVPAHEPSHRYDDQAWARPPKPPTFGEFL 334
           + ER +RHR+   + RREW+ +K   M       A E S R  D+      K     +  
Sbjct: 119 EHERRKRHREEQDKARREWERQKRREM-------AREHSRRERDRLEQLERKRERERKMR 171

Query: 335 SQHKA--EASSRRRRKSSRPQAKAAPRAYS--------DHDDRWETKEGAASPAPETPQP 384
            Q K   E   R RR   R + + A R  S        D+ D+ +    + SP P  P+ 
Sbjct: 172 EQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSP-PRPPRE 230

Query: 385 T----SPETSPKETPMQPPEI------------------PAPAHRPPEDEGEENEGEEDE 422
                      KE  M+  ++                   + A      E EE E EE+E
Sbjct: 231 RFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEE 290

Query: 423 EWEDISEDEEEEEIEVEEGDEEEPAQDHQAPEAAPTGIPCSEQAHGVPFSPEEPLLEPQA 482
           E    SE+ EEEE E EE +EE  +   +A E +   +   E +       E  LL    
Sbjct: 291 EEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLV--- 347

Query: 483 PGTPSSPFSPPSGHQPVSDWGEEVELNSPRTTHLAGALSPGEAWP 527
              P S F   SG    ++  EEV   +P+++    AL+ G+  P
Sbjct: 348 --VPESRFDRDSGESEEAE--EEVGEGTPQSS----ALTEGDYVP 384



 Score = 65.9 bits (159), Expect = 9e-11
 Identities = 87/352 (24%), Positives = 138/352 (39%), Gaps = 58/352 (16%)

Query: 159 RRRQNIEKMNEEMEKIAEYERNQREGVLEPNPVRNFLDDPRRRSGPLEESERDRREESRR 218
           RR  ++E   EE + +A     Q         V +  D+ R+        E++R  E R+
Sbjct: 68  RREDSMEDRGEEDDSLAIKPPQQMS---RKEKVHHRKDEKRKEKKHARVKEKEREHERRK 124

Query: 219 HGRNWGGPDFERVRCGLEHERQGRRAGLGSAGDMTLSMTGRERS--EYLRWKQEREKIDQ 276
             R       E+ +   E ERQ RR       +M    + RER   E L  K+ERE+  +
Sbjct: 125 RHRE------EQDKARREWERQKRR-------EMAREHSRRERDRLEQLERKRERERKMR 171

Query: 277 ERLQRHRKPTGQWRREWDAEKTDGMFKDGPVPAHEPSHR--YDDQA----WAR-PPKPPT 329
           E+ +  R+   + RR  +  K     ++  V AH  + R  Y D+     W+R PP+PP 
Sbjct: 172 EQQKEQREQKERERRAEERRKEREARRE--VSAHHRTMREDYSDKVKASHWSRSPPRPPR 229

Query: 330 ----FGEFLSQHKAEASSRR------------RRKSSRPQAKAAPRAYSDHDDRWETKEG 373
                G+     K E    R             RK+S  ++ +A       ++  E +E 
Sbjct: 230 ERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEE- 288

Query: 374 AASPAPETPQPTSPETSPKETPMQPPEIPAPAHRPPEDEGEENEGEEDEEWEDISEDEEE 433
                 E    TS E+  +E   +  E    ++    +E  E   EE  E E++SEDEE 
Sbjct: 289 -----EEEEGSTSEESEEEEEEEEEEEEETGSN---SEEASEQSAEEVSE-EEMSEDEER 339

Query: 434 EE-----IEVEEGDEEEPAQDHQAPEAAPTGIPCSEQAHGVPFSPEEPLLEP 480
           E      +  E   + +  +  +A E    G P S       + P+ P L P
Sbjct: 340 ENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSP 391


>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           4 [Homo sapiens]
          Length = 737

 Score = 66.2 bits (160), Expect = 7e-11
 Identities = 94/378 (24%), Positives = 146/378 (38%), Gaps = 70/378 (18%)

Query: 159 RRRQNIEKMNEEMEKIAEYERNQREGVLEPNPVRNFLDDPRRRSGPLEESERDRREESRR 218
           RR  ++E   EE + +A     Q         V +  D+ R+        E++R  E R+
Sbjct: 34  RREDSMEDRGEEDDSLAIKPPQQMS---RKEKVHHRKDEKRKEKKHARVKEKEREHERRK 90

Query: 219 HGRNWGGPDFERVRCGLEHERQGRRAGLGSAGDMTLSMTGRERS--EYLRWKQEREKIDQ 276
             R       E+ +   E ERQ RR       +M    + RER   E L  K+ERE+  +
Sbjct: 91  RHRE------EQDKARREWERQKRR-------EMAREHSRRERDRLEQLERKRERERKMR 137

Query: 277 ERLQRHRKPTGQWRREWDAEKTDGMFKDGPVPAHEPSHR--YDDQA----WAR-PPKPPT 329
           E+ +  R+   + RR  +  K     ++  V AH  + R  Y D+     W+R PP+PP 
Sbjct: 138 EQQKEQREQKERERRAEERRKEREARRE--VSAHHRTMREDYSDKVKASHWSRSPPRPPR 195

Query: 330 FGEFLSQHKAEASSRRRRKSSRPQAKAAPRAYSDHDDRWETKEGAASPAPETPQPTSPET 389
                 +       R+  K  + + +       D  D       A S + E+   +    
Sbjct: 196 ------ERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGS---- 245

Query: 390 SPKETPMQPPEIPAPAHRPPEDEGEENEGEEDEEWEDISEDEEEEEIEVEEGDEEEPAQD 449
                                 E EE E EE+EE    SE+ EEEE E EE +EE  +  
Sbjct: 246 ----------------------EEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNS 283

Query: 450 HQAPEAAPTGIPCSEQAHGVPFSPEEPLLEPQAPGTPSSPFSPPSGHQPVSDWGEEVELN 509
            +A E +   +   E +       E  LL       P S F   SG    ++  EEV   
Sbjct: 284 EEASEQSAEEVSEEEMSEDEERENENHLLV-----VPESRFDRDSGESEEAE--EEVGEG 336

Query: 510 SPRTTHLAGALSPGEAWP 527
           +P+++    AL+ G+  P
Sbjct: 337 TPQSS----ALTEGDYVP 350


>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           8 [Homo sapiens]
          Length = 780

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 93/380 (24%), Positives = 144/380 (37%), Gaps = 65/380 (17%)

Query: 159 RRRQNIEKMNEEMEKIAEYERNQREGVLEPNPVRNFLDDPRRRSGPLEESERDRREESRR 218
           RR  ++E   EE + +A     Q         V +  D+ R+        E++R  E R+
Sbjct: 68  RREDSMEDRGEEDDSLAIKPPQQMS---RKEKVHHRKDEKRKEKKHARVKEKEREHERRK 124

Query: 219 HGRNWGGPDFERVRCGLEHERQGRRAGLGSAGDMTLSMTG----RERSEYLRWKQEREKI 274
             R       E+ +   E ERQ RR              G    R+R E L  K+ERE+ 
Sbjct: 125 RHRE------EQDKARREWERQKRREMAREHSRRERGNDGVCLFRDRLEQLERKRERERK 178

Query: 275 DQERLQRHRKPTGQWRREWDAEKTDGMFKDGPVPAHEPSHR--YDDQA----WAR-PPKP 327
            +E+ +  R+   + RR  +  K     ++  V AH  + R  Y D+     W+R PP+P
Sbjct: 179 MREQQKEQREQKERERRAEERRKEREARRE--VSAHHRTMREDYSDKVKASHWSRSPPRP 236

Query: 328 PTFGEFLSQHKAEASSRRRRKSSRPQAKAAPRAYSDHDDRWETKEGAASPAPETPQPTSP 387
           P       +       R+  K  + + +       D  D       A S + E+   +  
Sbjct: 237 PR------ERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGS-- 288

Query: 388 ETSPKETPMQPPEIPAPAHRPPEDEGEENEGEEDEEWEDISEDEEEEEIEVEEGDEEEPA 447
                                   E EE E EE+EE    SE+ EEEE E EE +EE  +
Sbjct: 289 ------------------------EEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGS 324

Query: 448 QDHQAPEAAPTGIPCSEQAHGVPFSPEEPLLEPQAPGTPSSPFSPPSGHQPVSDWGEEVE 507
              +A E +   +   E +       E  LL       P S F   SG    ++  EEV 
Sbjct: 325 NSEEASEQSAEEVSEEEMSEDEERENENHLLV-----VPESRFDRDSGESEEAE--EEVG 377

Query: 508 LNSPRTTHLAGALSPGEAWP 527
             +P+++    AL+ G+  P
Sbjct: 378 EGTPQSS----ALTEGDYVP 393


>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           2 [Homo sapiens]
          Length = 782

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 100/413 (24%), Positives = 159/413 (38%), Gaps = 78/413 (18%)

Query: 157 EERRRQNIEKMNEEMEKIAEYERNQREGVLEPNPVRNFLDDPRRRSGPL--EESERDRRE 214
           E++RR+  E+  E        +R+ +   LE   +R+   +   R+ P   E+S  DR E
Sbjct: 19  EKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGE 78

Query: 215 ES--------RRHGRNWGGPDFERVRCGLEHERQGRRAGLGSAGDMTLSMTGRERSEYLR 266
           E         ++  R       E+V    + +R+ +R     +          E  ++ R
Sbjct: 79  EDDSLAIKPPQQMSRK------EKVHHRKDEKRKEKRRHRSHSA---------EGGKHAR 123

Query: 267 WKQEREKIDQERLQRHRKPTGQWRREWDAEKTDGMFKDGPVPAHEPSHRYDDQAWARPPK 326
            K++    + ER +RHR+   + RREW+ +K   M       A E S R  D+      K
Sbjct: 124 VKEKER--EHERRKRHREEQDKARREWERQKRREM-------AREHSRRERDRLEQLERK 174

Query: 327 PPTFGEFLSQHKA--EASSRRRRKSSRPQAKAAPRAYS--------DHDDRWETKEGAAS 376
                +   Q K   E   R RR   R + + A R  S        D+ D+ +    + S
Sbjct: 175 RERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRS 234

Query: 377 PAPETPQPT----SPETSPKETPMQPPEI------------------PAPAHRPPEDEGE 414
           P P  P+            KE  M+  ++                   + A      E E
Sbjct: 235 P-PRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEE 293

Query: 415 ENEGEEDEEWEDISEDEEEEEIEVEEGDEEEPAQDHQAPEAAPTGIPCSEQAHGVPFSPE 474
           E E EE+EE    SE+ EEEE E EE +EE  +   +A E +   +   E +       E
Sbjct: 294 EEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENE 353

Query: 475 EPLLEPQAPGTPSSPFSPPSGHQPVSDWGEEVELNSPRTTHLAGALSPGEAWP 527
             LL       P S F   SG    ++  EEV   +P+++    AL+ G+  P
Sbjct: 354 NHLLV-----VPESRFDRDSGESEEAE--EEVGEGTPQSS----ALTEGDYVP 395



 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 89/355 (25%), Positives = 141/355 (39%), Gaps = 53/355 (14%)

Query: 159 RRRQNIEKMNEEMEKIAEYERNQ--REGVLEPNPVRNFLDDPRRRSGPLEESERDR-REE 215
           RR  ++E   EE + +A     Q  R+  +         +  R RS   E  +  R +E+
Sbjct: 68  RREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSAEGGKHARVKEK 127

Query: 216 SRRHGRNWGGPDFERVRCGLEHERQGRRAGLGSAGDMTLSMTGRERS--EYLRWKQEREK 273
            R H R     + E+ +   E ERQ RR       +M    + RER   E L  K+ERE+
Sbjct: 128 EREHERRKRHRE-EQDKARREWERQKRR-------EMAREHSRRERDRLEQLERKRERER 179

Query: 274 IDQERLQRHRKPTGQWRREWDAEKTDGMFKDGPVPAHEPSHR--YDDQA----WAR-PPK 326
             +E+ +  R+   + RR  +  K     ++  V AH  + R  Y D+     W+R PP+
Sbjct: 180 KMREQQKEQREQKERERRAEERRKEREARRE--VSAHHRTMREDYSDKVKASHWSRSPPR 237

Query: 327 PPT----FGEFLSQHKAEASSRR------------RRKSSRPQAKAAPRAYSDHDDRWET 370
           PP      G+     K E    R             RK+S  ++ +A       ++  E 
Sbjct: 238 PPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEE 297

Query: 371 KEGAASPAPETPQPTSPETSPKETPMQPPEIPAPAHRPPEDEGEENEGEEDEEWEDISED 430
           +E       E    TS E+  +E   +  E    ++    +E  E   EE  E E++SED
Sbjct: 298 EE------EEEEGSTSEESEEEEEEEEEEEEETGSN---SEEASEQSAEEVSE-EEMSED 347

Query: 431 EEEEE-----IEVEEGDEEEPAQDHQAPEAAPTGIPCSEQAHGVPFSPEEPLLEP 480
           EE E      +  E   + +  +  +A E    G P S       + P+ P L P
Sbjct: 348 EERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSP 402


>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
          Length = 780

 Score = 63.5 bits (153), Expect = 4e-10
 Identities = 99/405 (24%), Positives = 152/405 (37%), Gaps = 64/405 (15%)

Query: 157 EERRRQNIEKMNEEMEKIAEYERNQREGVLEPNPVRNFLDDPRRRSGPL--EESERDRRE 214
           E++RR+  E+  E        +R+ +   LE   +R+   +   R+ P   E+S  DR E
Sbjct: 19  EKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDRGE 78

Query: 215 ESRRHGRNWGGPDFERVRCGLEHERQGRRAGLGSAGDMTLSMTGRERSEYLRWKQEREKI 274
           E          P  +  R    H R+  +                E  ++ R K+     
Sbjct: 79  EDDSLAIK---PPQQMSRKEKVHHRKDEKR----KEKCRHHSHSAEGGKHARVKER---- 127

Query: 275 DQERLQRHRKPTGQWRREWDAEKTDGMFKDGPVPAHEPSHRYDDQAWARPPKPPTFGEFL 334
           + ER +RHR+   + RREW+ +K   M       A E S R  D+      K     +  
Sbjct: 128 EHERRKRHREEQDKARREWERQKRREM-------AREHSRRERDRLEQLERKRERERKMR 180

Query: 335 SQHKA--EASSRRRRKSSRPQAKAAPRAYS--------DHDDRWETKEGAASPAPETPQP 384
            Q K   E   R RR   R + + A R  S        D+ D+ +    + SP P  P+ 
Sbjct: 181 EQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSP-PRPPRE 239

Query: 385 T----SPETSPKETPMQPPEI------------------PAPAHRPPEDEGEENEGEEDE 422
                      KE  M+  ++                   + A      E EE E EE+E
Sbjct: 240 RFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEE 299

Query: 423 EWEDISEDEEEEEIEVEEGDEEEPAQDHQAPEAAPTGIPCSEQAHGVPFSPEEPLLEPQA 482
           E    SE+ EEEE E EE +EE  +   +A E +   +   E +       E  LL    
Sbjct: 300 EEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLV--- 356

Query: 483 PGTPSSPFSPPSGHQPVSDWGEEVELNSPRTTHLAGALSPGEAWP 527
              P S F   SG    ++  EEV   +P+++    AL+ G+  P
Sbjct: 357 --VPESRFDRDSGESEEAE--EEVGEGTPQSS----ALTEGDYVP 393



 Score = 59.3 bits (142), Expect = 8e-09
 Identities = 84/367 (22%), Positives = 135/367 (36%), Gaps = 71/367 (19%)

Query: 142 GAGDTSISDRKSKEWEERRRQNIEKMNEEMEKIAEYERNQREGVLEPNPVRNFLDDPRRR 201
           G  D S++ +  ++   + + +  K  +  EK   +  +   G       R    +  RR
Sbjct: 77  GEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKCRHHSHSAEGG----KHARVKEREHERR 132

Query: 202 SGPLEESERDRREESRRHGRNWGGPDFERVRCGLEHERQGRRAGLGSAGDMTLSMTGRER 261
               EE ++ RRE  R+  R        R R  LE   + R                RER
Sbjct: 133 KRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRE---------------RER 177

Query: 262 SEYLRWKQEREKIDQERLQRHRKPTGQWRREWDAEKTDGMFKDGPVPAHEPSHR--YDDQ 319
               + K++RE+ ++ER    R+   + RRE              V AH  + R  Y D+
Sbjct: 178 KMREQQKEQREQKERERRAEERRKEREARRE--------------VSAHHRTMREDYSDK 223

Query: 320 A----WAR-PPKPPT----FGEFLSQHKAEASSRR------------RRKSSRPQAKAAP 358
                W+R PP+PP      G+     K E    R             RK+S  ++ +A 
Sbjct: 224 VKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAE 283

Query: 359 RAYSDHDDRWETKEGAASPAPETPQPTSPETSPKETPMQPPEIPAPAHRPPEDEGEENEG 418
                 ++  E +E       E    TS E+  +E   +  E    ++    +E  E   
Sbjct: 284 SGSGSEEEEEEEEE------EEEEGSTSEESEEEEEEEEEEEEETGSN---SEEASEQSA 334

Query: 419 EEDEEWEDISEDEEEEE-----IEVEEGDEEEPAQDHQAPEAAPTGIPCSEQAHGVPFSP 473
           EE  E E++SEDEE E      +  E   + +  +  +A E    G P S       + P
Sbjct: 335 EEVSE-EEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVP 393

Query: 474 EEPLLEP 480
           + P L P
Sbjct: 394 DSPALLP 400


>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           5 [Homo sapiens]
          Length = 748

 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 77/291 (26%), Positives = 115/291 (39%), Gaps = 52/291 (17%)

Query: 269 QEREKIDQERLQRHRKPTGQWRREWDAEKTDGMFKDGPVPAHEPSHRYDDQAWARPPKPP 328
           +E+E+ + ER +RHR+   + RREW+ +K   M       A E S R  D+      K  
Sbjct: 91  KEKER-EHERRKRHREEQDKARREWERQKRREM-------AREHSRRERDRLEQLERKRE 142

Query: 329 TFGEFLSQHKA--EASSRRRRKSSRPQAKAAPRAYS--------DHDDRWETKEGAASPA 378
              +   Q K   E   R RR   R + + A R  S        D+ D+ +    + SP 
Sbjct: 143 RERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSP- 201

Query: 379 PETPQPT----SPETSPKETPMQPPEI------------------PAPAHRPPEDEGEEN 416
           P  P+            KE  M+  ++                   + A      E EE 
Sbjct: 202 PRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEE 261

Query: 417 EGEEDEEWEDISEDEEEEEIEVEEGDEEEPAQDHQAPEAAPTGIPCSEQAHGVPFSPEEP 476
           E EE+EE    SE+ EEEE E EE +EE  +   +A E +   +   E +       E  
Sbjct: 262 EEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENH 321

Query: 477 LLEPQAPGTPSSPFSPPSGHQPVSDWGEEVELNSPRTTHLAGALSPGEAWP 527
           LL       P S F   SG    ++  EEV   +P+++    AL+ G+  P
Sbjct: 322 LLV-----VPESRFDRDSGESEEAE--EEVGEGTPQSS----ALTEGDYVP 361



 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 89/355 (25%), Positives = 141/355 (39%), Gaps = 53/355 (14%)

Query: 159 RRRQNIEKMNEEMEKIAEYERNQ--REGVLEPNPVRNFLDDPRRRSGPLEESERDR-REE 215
           RR  ++E   EE + +A     Q  R+  +         +  R RS   E  +  R +E+
Sbjct: 34  RREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSAEGGKHARVKEK 93

Query: 216 SRRHGRNWGGPDFERVRCGLEHERQGRRAGLGSAGDMTLSMTGRERS--EYLRWKQEREK 273
            R H R     + E+ +   E ERQ RR       +M    + RER   E L  K+ERE+
Sbjct: 94  EREHERRKRHRE-EQDKARREWERQKRR-------EMAREHSRRERDRLEQLERKRERER 145

Query: 274 IDQERLQRHRKPTGQWRREWDAEKTDGMFKDGPVPAHEPSHR--YDDQA----WAR-PPK 326
             +E+ +  R+   + RR  +  K     ++  V AH  + R  Y D+     W+R PP+
Sbjct: 146 KMREQQKEQREQKERERRAEERRKEREARRE--VSAHHRTMREDYSDKVKASHWSRSPPR 203

Query: 327 PPT----FGEFLSQHKAEASSRR------------RRKSSRPQAKAAPRAYSDHDDRWET 370
           PP      G+     K E    R             RK+S  ++ +A       ++  E 
Sbjct: 204 PPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEE 263

Query: 371 KEGAASPAPETPQPTSPETSPKETPMQPPEIPAPAHRPPEDEGEENEGEEDEEWEDISED 430
           +E       E    TS E+  +E   +  E    ++    +E  E   EE  E E++SED
Sbjct: 264 EE------EEEEGSTSEESEEEEEEEEEEEEETGSN---SEEASEQSAEEVSE-EEMSED 313

Query: 431 EEEEE-----IEVEEGDEEEPAQDHQAPEAAPTGIPCSEQAHGVPFSPEEPLLEP 480
           EE E      +  E   + +  +  +A E    G P S       + P+ P L P
Sbjct: 314 EERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSP 368


>gi|4503509 eukaryotic translation initiation factor 3, subunit 10
            theta, 150/170kDa [Homo sapiens]
          Length = 1382

 Score = 59.3 bits (142), Expect = 8e-09
 Identities = 113/483 (23%), Positives = 174/483 (36%), Gaps = 67/483 (13%)

Query: 7    LKSKEEKD-AELDKRIEALRRKNEALIRRYQEIEEDRKKAELEGVAVTAPRKGRSVEKEN 65
            LK +EE++ AE  KR E LR   E  +++ +E+E  +++ ELE            +E+  
Sbjct: 823  LKEREERERAERAKREEELREYQER-VKKLEEVERKKRQRELE------------IEERE 869

Query: 66   VAVESEKNLGPS-----------RRSPGTPR--PPGASKGGRTPPQQGGRAGMGRASRSW 112
               E E+ LG S           R S GT R  P   S+  R PP++  R G GR     
Sbjct: 870  RRREEERRLGDSSLSRKDSRWGDRDSEGTWRKGPEADSEWRRGPPEKEWRRGEGRDEDRS 929

Query: 113  EGSPGEQPRGGGAGGRGR--------RGRGRGSPHLSGAGDTSISDRKSKEWEERRRQNI 164
                 E+PR  G              R   RG     G       DR S+   +  R + 
Sbjct: 930  HRRDEERPRRLGDDEDREPSLRPDDDRVPRRGMDDDRGPRRGPEEDRFSRRGADDDRPSW 989

Query: 165  EKMNEEM--EKIAEYERNQREGVLEPNPVRNFLDDPRRRSGPLEESERDRREESRRHGRN 222
               +++    +IA+ +R       +  P R  LD+ R      +E    RR      G  
Sbjct: 990  RNTDDDRPPRRIADEDRGNWRHADDDRPPRRGLDEDRGSWRTADEDRGPRRGMDDDRGPR 1049

Query: 223  WGGPDFERVRCGLEHERQGRRAGLGSAGDMTLSMTGRERSEYLRWKQEREKIDQERLQRH 282
             GG D ER       + +G R GL    D      G +     R   + ++  +  +   
Sbjct: 1050 RGGADDERSSWRNADDDRGPRRGL---DDDRGPRRGMDDDRGPRRGMDDDRGPRRGMDDD 1106

Query: 283  RKP-------TGQWRREWD-------AEKTDGMFKDGPVPAHEPSHRYDDQAWARPPKPP 328
            R P        G WR   D       AE   G +++  +     S R DD  + R     
Sbjct: 1107 RGPRRGLDDDRGPWRNADDDRIPRRGAEDDRGPWRN--MDDDRLSRRADDDRFPRRGDDS 1164

Query: 329  TFGEFLSQHKAEASSRRRRKSSRPQAKAAPRAYSDHDDR-WE-TKEGAASPAPETPQPTS 386
              G +  +   +    R ++ +R ++   PR     ++R W+  KE              
Sbjct: 1165 RPGPW--RPLVKPGGWREKEKAREESWGPPRESRPSEEREWDREKERDRDNQDREENDKD 1222

Query: 387  PETSPKETPMQPPEIPAPAHRPPEDEGEENEG--EEDEEWEDIS--EDEEEEEIEVEEGD 442
            PE   +E   +         R P DEG    G  EE   W D S  +D + ++   E  D
Sbjct: 1223 PE---RERDRERDVDREDRFRRPRDEGGWRRGPAEESSSWRDSSRRDDRDRDDRRRERDD 1279

Query: 443  EEE 445
              +
Sbjct: 1280 RRD 1282



 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 96/462 (20%), Positives = 162/462 (35%), Gaps = 60/462 (12%)

Query: 26   RKNEALIRRYQEIEEDRKKAELEGVAVTAPRKG--------RSVEKENVAVESEKNLGPS 77
            R++E   RR  + +EDR+ + L       PR+G        R  E++  +     +  PS
Sbjct: 931  RRDEERPRRLGD-DEDREPS-LRPDDDRVPRRGMDDDRGPRRGPEEDRFSRRGADDDRPS 988

Query: 78   RRSPGTPRPP----GASKGG--RTPPQQGGRAGMGRASRSWEGSPGEQ-PRGGGAGGRGR 130
             R+    RPP       +G        +  R G+     SW  +  ++ PR G    RG 
Sbjct: 989  WRNTDDDRPPRRIADEDRGNWRHADDDRPPRRGLDEDRGSWRTADEDRGPRRGMDDDRGP 1048

Query: 131  RGRGRGSPHLSGAG-DTSISDRKSKEWEERRRQNIEKMNEEMEKIAEYERNQREGVLEPN 189
            R  G      S    D     R+  + +   R+ ++  +    +  + +R  R G+ +  
Sbjct: 1049 RRGGADDERSSWRNADDDRGPRRGLDDDRGPRRGMDD-DRGPRRGMDDDRGPRRGMDDDR 1107

Query: 190  PVRNFLDDPRRRSGPLEESERDR--REESRRHGRNWGGPDFERVRCGLEHERQGRRAG-- 245
              R  LDD R   GP   ++ DR  R  +      W   D +R+    + +R  RR    
Sbjct: 1108 GPRRGLDDDR---GPWRNADDDRIPRRGAEDDRGPWRNMDDDRLSRRADDDRFPRRGDDS 1164

Query: 246  -------LGSAGDMTLSMTGRERS----------EYLRW--KQEREKIDQERLQRHRKPT 286
                   L   G        RE S          E   W  ++ER++ +Q+R +  + P 
Sbjct: 1165 RPGPWRPLVKPGGWREKEKAREESWGPPRESRPSEEREWDREKERDRDNQDREENDKDPE 1224

Query: 287  GQWRREWDAEKTDGMFKDGPVPAHEPSHRYDDQAWARPP--KPPTFGEFLSQHKAEASSR 344
             +  RE D ++ D   +             D+  W R P  +  ++ +   +   +   R
Sbjct: 1225 RERDRERDVDREDRFRRPR-----------DEGGWRRGPAEESSSWRDSSRRDDRDRDDR 1273

Query: 345  RRRKSSRPQAKAAPRAYSDHDDRWETKEGAASPAPETPQPTSPETSPKETPMQPPEIPAP 404
            RR +  R   +       D D R               +    +    E    P  +P P
Sbjct: 1274 RRERDDRRDLRERRDLRDDRDRRGPPLRSEREEVSSWRRADDRKDDRVEERDPPRRVPPP 1333

Query: 405  A--HRPPEDEGEENEGEEDEEWEDISEDEEEEEIEVEEGDEE 444
            A       D   E EGE+++      +D E       E DE+
Sbjct: 1334 ALSRDRERDRDREREGEKEKASWRAEKDRESLRRTKNETDED 1375



 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 64/303 (21%), Positives = 106/303 (34%), Gaps = 61/303 (20%)

Query: 156  WEERRRQNIEKMNEEMEKIAEYERNQREGVLEPNPVRNFLDDPRRRSGPLEESERDRREE 215
            +EE+ +Q  E++ EE     E  + QR+        R   ++ +RR+      ER+ RE 
Sbjct: 772  YEEKLKQFEERLAEERHNRLEERKRQRKEERRITYYREKEEEEQRRAEEQMLKEREERER 831

Query: 216  SRRHGRNWGGPDF-ERVRCGLEHERQGRRAGLGSAGDMTLSMTGRERSEYLRWKQEREKI 274
            + R  R     ++ ERV+   E ER+ R+  L             E  E  R ++E  ++
Sbjct: 832  AERAKREEELREYQERVKKLEEVERKKRQREL-------------EIEERERRREEERRL 878

Query: 275  DQERLQRHRKPTGQWRREWDAEKTDGMFKDGPVPAHEPSHRYDDQAWARPPKPPTFGEFL 334
                L R           W    ++G ++ GP           D  W R P    +    
Sbjct: 879  GDSSLSRKDS-------RWGDRDSEGTWRKGPEA---------DSEWRRGPPEKEWRR-- 920

Query: 335  SQHKAEASSRRRRKSSRPQAKAAPRAYSDHDDRWETKEGAASPAPETPQPTSPETSPKE- 393
             + + E  S RR +         PR   D +DR                   P   P + 
Sbjct: 921  GEGRDEDRSHRRDEE-------RPRRLGDDEDR------------------EPSLRPDDD 955

Query: 394  -TPMQPPEIPAPAHRPPEDEGEENEGEEDE--EWEDISEDEEEEEIEVEEGDEEEPAQDH 450
              P +  +      R PE++     G +D+   W +  +D     I  E+      A D 
Sbjct: 956  RVPRRGMDDDRGPRRGPEEDRFSRRGADDDRPSWRNTDDDRPPRRIADEDRGNWRHADDD 1015

Query: 451  QAP 453
            + P
Sbjct: 1016 RPP 1018



 Score = 38.9 bits (89), Expect = 0.012
 Identities = 47/184 (25%), Positives = 70/184 (38%), Gaps = 19/184 (10%)

Query: 152  KSKEWE-ERRRQNIEKMNEEMEKIAEYERNQREGVLEPNPVRNFLDDPRRRSGPLEESER 210
            + +EW+ E+ R    +  EE +K  E ER++   V   +  R   D+   R GP EES  
Sbjct: 1199 EEREWDREKERDRDNQDREENDKDPERERDRERDVDREDRFRRPRDEGGWRRGPAEESS- 1257

Query: 211  DRREESRRHGRNWGGPDFERVRCGLEHERQGRRAGLGSAGDMTLSMTGRERSEYLRWKQE 270
              R+ SRR  R+      ER       ER+  R      G    S    ER E   W++ 
Sbjct: 1258 SWRDSSRRDDRDRDDRRRERDDRRDLRERRDLRDDRDRRGPPLRS----EREEVSSWRRA 1313

Query: 271  REKID---QER----------LQRHRKPTGQWRREWDAEKTDGMFKDGPVPAHEPSHRYD 317
             ++ D   +ER          L R R+      RE + EK     +          +  D
Sbjct: 1314 DDRKDDRVEERDPPRRVPPPALSRDRERDRDREREGEKEKASWRAEKDRESLRRTKNETD 1373

Query: 318  DQAW 321
            +  W
Sbjct: 1374 EDGW 1377



 Score = 32.7 bits (73), Expect = 0.85
 Identities = 68/332 (20%), Positives = 126/332 (37%), Gaps = 50/332 (15%)

Query: 148 ISDRKSKEWEERRRQNIEKMNEEMEKIAEYERNQREGVLEPNP-VRNFLDDPRRRSGPLE 206
           I  ++ ++ E+ +++  E++  + +KI  +ER +R   LE  P +++  ++ R +   L 
Sbjct: 669 IMAKQVEQLEKEKKELQERLKNQEKKIDYFERAKR---LEEIPLIKSAYEEQRIKDMDLW 725

Query: 207 ESERDRREESRRHGRNWGGPDFERVRCGLEHERQGRRAGLGSAGDMTLSMTGRERSEYL- 265
           E + + R  + +          ER +  LEH+ +  R  L       + +    +S Y  
Sbjct: 726 EQQEEERITTMQ---------LEREKA-LEHKNRMSRM-LEDRDLFVMRLKAARQSVYEE 774

Query: 266 RWKQEREKIDQER---LQRHRKPTGQWRR---------EWDAEKTDGMFKDGPVPAHEPS 313
           + KQ  E++ +ER   L+  ++   + RR         E      + M K+         
Sbjct: 775 KLKQFEERLAEERHNRLEERKRQRKEERRITYYREKEEEEQRRAEEQMLKEREERERAER 834

Query: 314 HRYDDQA---WARPPKPPTFGEFLSQHKAEASSRRRRKSSRPQAKAAPRAYSDHDDRWET 370
            + +++      R  K         Q + E   R RR+    + +    + S  D RW  
Sbjct: 835 AKREEELREYQERVKKLEEVERKKRQRELEIEERERRREE--ERRLGDSSLSRKDSRWGD 892

Query: 371 K--EGAASPAPETPQPTSPETSPKETPMQPPEIPAPAHRPPEDEGEENEGEEDEEWEDIS 428
           +  EG     PE         +  E    PPE      R  E   E+     DEE     
Sbjct: 893 RDSEGTWRKGPE---------ADSEWRRGPPE---KEWRRGEGRDEDRSHRRDEERPRRL 940

Query: 429 EDEEEEEIEVEEGDEEEPAQ---DHQAPEAAP 457
            D+E+ E  +   D+  P +   D + P   P
Sbjct: 941 GDDEDREPSLRPDDDRVPRRGMDDDRGPRRGP 972


>gi|50962882 G patch domain containing 8 [Homo sapiens]
          Length = 1502

 Score = 59.3 bits (142), Expect = 8e-09
 Identities = 122/612 (19%), Positives = 196/612 (32%), Gaps = 144/612 (23%)

Query: 7    LKSKEEKDAELDKRIEALRRKNEALIRRYQEIEEDRKKAELEGVAVTAPRKGRSVEKENV 66
            L SK+E+  +  +  +  + K  +  +R  + + + K ++ E    +  RK R  +K   
Sbjct: 662  LPSKKERSGKSHRHKKKKKHKKSSKHKRKHKADTEEKSSKAESGEKSKKRKKRKRKKNKS 721

Query: 67   AVESEKNLGPSRRSPGTPRPPGASKGGRTPPQQGGRA---GMGRASRSWEGSPGEQPRGG 123
            +  ++   GP    PG+        G   PP++  RA      R+  + EGS G++  GG
Sbjct: 722  SAPADSERGPKPEPPGS--------GSPAPPRRRRRAQDDSQRRSLPAEEGSSGKKDEGG 773

Query: 124  GA------GGRGRRG--------------RGRGSPHLS--GAGDTSISDRKSKEWEERRR 161
            G       GGR  +G              R   S H S   +GD    D  S    ++  
Sbjct: 774  GGSSSQDHGGRKHKGELPPSSCQRRAGTKRSSRSSHRSQPSSGDEDSDDASSHRLHQKSP 833

Query: 162  QNIEKMNEEMEKIAEYERNQ-------------------------------REGVLEPNP 190
                +  EE +  +E+ R++                               R+     + 
Sbjct: 834  SQYSEEEEEEDSGSEHSRSRSRSGRRHSSHRSSRRSYSSSSDASSDQSCYSRQRSYSDDS 893

Query: 191  VRNFLDDPRRRSGPLEESE----RDRREESRRHGRNWGGPDF------ERVRCGLEHERQ 240
              ++ D  RR S    +S+       +  S+RH  +    D+       R R       +
Sbjct: 894  YSDYSDRSRRHSKRSHDSDDSDYASSKHRSKRHKYSSSDDDYSLSCSQSRSRSRSHTRER 953

Query: 241  GRRAGLGSAGDMTLSMT-GRERSEYLRWKQEREKIDQERLQRHRKP---TGQWRREWDAE 296
             R  G   +   + S +  R RS      Q      ++R +  R P   +G  +R W  E
Sbjct: 954  SRSRGRSRSSSCSRSRSKRRSRSTTAHSWQRSRSYSRDRSRSTRSPSQRSGSRKRSWGHE 1013

Query: 297  KTDGMFKD----------------------GPVPAHEPSHRYDDQAWARPPKPPTFGEFL 334
              +                           G  P  +   R DD     PP         
Sbjct: 1014 SPEERHSGRRDFIRSKIYRSQSPHYFRSGRGEGPGKKDDGRGDDSKATGPP--------- 1064

Query: 335  SQHKAEASSRRRRKSSRPQAKAAPRA----YSDHDDRWETKEGAASPAPETPQPTSPETS 390
            SQ+    + R       P+ K +  A          + E K   +     TP    P+  
Sbjct: 1065 SQNSNIGTGRGSEGDCSPEDKNSVTAKLLLEKIQSRKVERKPSVSEEVQATPNKAGPKLK 1124

Query: 391  PKETPMQPPEIP--------------APAHRPPEDEGEENEGEEDEEWEDISEDEEEEEI 436
                    P++P               PA R P  + EE+          +   EE+E+ 
Sbjct: 1125 DPPQGYFGPKLPPSLGNKPVLPLIGKLPATRKPNKKCEES---------GLERGEEQEQS 1175

Query: 437  EVEEG--DEEEPAQDHQAPEAAPTGIPCSEQAHGVPFSPEEPLLEPQAP-GTPSS----P 489
            E EEG     +    HQ P    TG P  +       S E     P AP GTP+     P
Sbjct: 1176 ETEEGPPGSSDALFGHQFPSEETTG-PLLDPPPEESKSGEATADHPVAPLGTPAHSDCYP 1234

Query: 490  FSPPSGHQPVSD 501
              P   H  + D
Sbjct: 1235 GDPTISHNYLPD 1246



 Score = 31.6 bits (70), Expect = 1.9
 Identities = 28/99 (28%), Positives = 39/99 (39%), Gaps = 10/99 (10%)

Query: 6   DLKSKEEKDAELDKRIEALRRKNEALIRRYQEIEEDRKKAELEGVAVTAPRKGRSVEKEN 65
           DLK +E     +  R     +K E  +RR  E+ E RK+AE       AP  G   +   
Sbjct: 168 DLKQREFA-RNVSSRSRKDEKKQEKALRRLHELAEQRKQAE------CAPGSGPMFKPTT 220

Query: 66  VAVE---SEKNLGPSRRSPGTPRPPGASKGGRTPPQQGG 101
           VAV+    E +   S  + GT        G      +GG
Sbjct: 221 VAVDEEGGEDDKDESATNSGTGATASCGLGSEFSTDKGG 259


>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
           sapiens]
          Length = 436

 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 88/452 (19%), Positives = 166/452 (36%), Gaps = 36/452 (7%)

Query: 11  EEKDAELDKRIEALRRKNEALIRRYQEIEEDRKKAELEGVAVTAPRKGRSVEKENVAVES 70
           +EK+AEL + ++ +  +   +    +E+     K +LE   +  P++G+  E+E    E 
Sbjct: 10  KEKNAELQEELQLVETEKSEIQLHIKEL-----KRKLETDKIPLPQEGQVREQEGQVREQ 64

Query: 71  EKNLGPSRRSPGTPRPPGASKGGRTPPQQGGRAGMGRASRSWEGSPGEQPRGGGAGGRGR 130
           E   G  R   G  R     + G+   Q+G         R  EG   EQ       G+ R
Sbjct: 65  E---GQVREQEGQVR----EQEGQVREQEGQVREQEGQVREQEGQVREQE------GQVR 111

Query: 131 RGRGRGSPHLSGAGDTSISDRKSKEWEERRRQNIEKMNEEMEKIAEYERNQREGVLEPNP 190
              G+        G     + + +E E + R+   ++ E+  ++ E E   RE   +   
Sbjct: 112 EQEGQVREQ---EGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE---QEGQ 165

Query: 191 VRNFLDDPRRRSGPLEESERDRREESRRHGRNWGGPDFERVRCGLEHERQGRRAGLGSAG 250
           VR      R + G + E E   RE+  + G   G    +  + G + E+  ++       
Sbjct: 166 VREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQ 225

Query: 251 DMTLSMTGRERSEYLRWKQEREKIDQERLQRHRKPTGQWRREWDA--EKTDGMFKDGPVP 308
           +  +     +  E     Q++E+  Q++ ++ RK   Q R + +   E+ + M K     
Sbjct: 226 EEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQT 285

Query: 309 AHEPSHRYDDQAWARPPKPPTFGEFLSQHKAEASSRRRRKSSRPQAKAAPRAYSDHDDRW 368
             E      ++      +     E   + + E    + R+      K   + +   +  W
Sbjct: 286 EQEEQTGEQEEQMREQEEQMREQEEQMREQEE----QMREQEEQMGKQEEQMWEQKEQMW 341

Query: 369 ETKEGA------ASPAPETPQPTSPETSPKETPMQPPEIPAPAHRPPEDEGEENEGEEDE 422
           E KE             E  Q    +   +E  M+  E           + EE  GE+ E
Sbjct: 342 EQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKE 401

Query: 423 EWEDISEDEEEEEIEVEEGDEEEPAQDHQAPE 454
           +  +  E   E+E ++ E  E+   Q+    E
Sbjct: 402 QMGEQKEQMREQEEQMGEQKEQMRKQEEHMGE 433


>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
          Length = 1332

 Score = 56.6 bits (135), Expect = 5e-08
 Identities = 85/365 (23%), Positives = 131/365 (35%), Gaps = 56/365 (15%)

Query: 159 RRRQNIEKMNEEMEKIAEYERNQREGVLEPNPVRNFLDDPRRRSGPLEESERDRREESRR 218
           +R++ IE+  EE  ++ E +R +RE        R   +  ++R   LE+ +  RREE RR
Sbjct: 393 QRQRRIEEQKEERRRVEEQQRREREQ-------RKLQEKEQQRR--LEDMQALRREEERR 443

Query: 219 HGRNWGGPDFERVRCGLEHERQGRRAG--LGSAGDMTLSMTGRERSEYLRWKQEREKIDQ 276
                   + E  R  LE +RQ  R    L        S+  +++ + L+ +Q+++ +  
Sbjct: 444 QAER----EQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPG 499

Query: 277 ERLQRHRKPTGQ-------WRREWDAEKTDGMFKDGPVPAHEPSHRYDD----QAWARPP 325
           +R   +    G        W RE +        ++ P+   +P     +    QA   PP
Sbjct: 500 DRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQASPGPP 559

Query: 326 -----KPPTFGEFLSQHKAEASSRRRRKSSRPQAKAAPRAYSDHDDRWETKEGAASPAPE 380
                 PP       Q     S    R   +P A   PR+ S  D    T+  AA PA  
Sbjct: 560 GPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQ--PTRNLAAFPASH 617

Query: 381 TPQPTSPETSPKETPMQ-----------PPEIPAPAHRPPEDEGEENEGEEDEEWEDISE 429
            P P  P  +P  TP               E P P+  PP     +NE          S 
Sbjct: 618 DPDPAIP--APTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRPDNEAPPKVPQRTSSI 675

Query: 430 DEEEEEIEVEEGDEEEPAQDHQAPEAAPTGIPCSEQAHGVPFSPEEPLLEPQAPGTPSSP 489
                 +         PAQ  +A        P S  A  +          P+ PG P+ P
Sbjct: 676 ---ATALNTSGAGGSRPAQAVRAR-------PRSNSAWQIYLQRRAERGTPKPPGPPAQP 725

Query: 490 FSPPS 494
             PP+
Sbjct: 726 PGPPN 730



 Score = 35.0 bits (79), Expect = 0.17
 Identities = 36/148 (24%), Positives = 53/148 (35%), Gaps = 21/148 (14%)

Query: 78  RRSPGTPRPPGASKGGRTPPQQGGRAGMGRASRSWEGSPGEQPRGGG----AGG--RGRR 131
           R   GTP+PPG       PP       + R+   WE S    P   G    AG   R R 
Sbjct: 710 RAERGTPKPPGPPAQPPGPPNASSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRV 769

Query: 132 G---RGRGSPHLSGAGDTSISDRKSK-----EWEERRRQNIEKMNEEMEKIAEYERNQRE 183
           G   +   SP LS        D +S+     ++   + + +++     +K  +Y  +  E
Sbjct: 770 GVSSKPDSSPVLSPGNKAKPDDHRSRPGRPADFVLLKERTLDEAPRPPKKAMDYSSSSEE 829

Query: 184 GVLEPNPVRNFLDDPRRRSGPLEESERD 211
                  V +  DD     G   E  RD
Sbjct: 830 -------VESSEDDEEEGEGGPAEGSRD 850


>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 828

 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 63/313 (20%), Positives = 129/313 (41%), Gaps = 29/313 (9%)

Query: 150 DRKSKEWEERRRQNIEKMNEEMEKIAEYER--NQREGVLEPNPVRNFLDDPRRRSGPLEE 207
           ++K ++ EER  +  E++ E+ E++ E E+   Q E + E   +R    +  ++    EE
Sbjct: 351 EQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIR----EREKKMREEEE 406

Query: 208 SERDRREESRRHGRN-WGGPDFERVRCGLEHERQGRRAGLGSAGDMTLSMTGRERSEYLR 266
           + R++ E+ ++   N W            + E++ ++  L    +        +  E   
Sbjct: 407 TMREQEEKMQKQEENMWE-----------QEEKEWQQQRLPEQKEKLWEQEKMQEQEEKI 455

Query: 267 WKQEREKIDQERLQRHRKPTGQWRREWDAEKTDGMFKDGPVPAHEPSHRYD--DQAWARP 324
           W+QE +  DQE +    K    WR+E   E+ D M++       +    +D  ++ W + 
Sbjct: 456 WEQEEKIRDQEEMWGQEKK--MWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQD 513

Query: 325 PKPPTFGEFLSQHKA----EASSRRRRKSSRPQAKAAPRAYS-DHDDRWETKEGAASPAP 379
            +     E + + K     E   R  +K+   + K   +      ++R   +E       
Sbjct: 514 ERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEE 573

Query: 380 ETPQPTSPETSPKETPMQPPEIPAPAHRPPEDEGEENEGEEDEE-WEDISEDEEEEEIEV 438
           E  +    +   +E  M+  E           E EE   E++E+ WE   ED+ +E+ E+
Sbjct: 574 EMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEM 633

Query: 439 EEGDEEEPAQDHQ 451
              ++EE  Q+ +
Sbjct: 634 -MWEQEEKMQEQE 645



 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 63/320 (19%), Positives = 123/320 (38%), Gaps = 32/320 (10%)

Query: 145 DTSISDRKSKEWE--ERRRQNIEKMNEEMEKIAEYERNQREGVLEPNPVRNFLDDPRRRS 202
           +  + +++ K WE  E+ R+  EKM  + E++ E E+  RE   +       + D   R 
Sbjct: 309 EEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQK-------MRDQEERM 361

Query: 203 GPLEESERDRREESRRHGRNWGGPDF----ERVRCGLEHERQGRRAGLGSAGDMTLSMTG 258
              +E  R++ E  R   + W   +     ER+R   E E++ R         M      
Sbjct: 362 WEQDERLREKEERMREQEKMWEQEEKMQEEERIR---EREKKMRE----EEETMREQEEK 414

Query: 259 RERSEYLRWKQEREKIDQERLQRHRKPTGQWRREWDAEKTDGMFKDGPVPAHEPSHRYDD 318
            ++ E   W+QE ++  Q+RL   ++    W +E   E+ + +++       E   R  +
Sbjct: 415 MQKQEENMWEQEEKEWQQQRLPEQKEKL--WEQEKMQEQEEKIWEQ------EEKIRDQE 466

Query: 319 QAWARPPKPPTFGEFLSQHKAEASSRRRRKSSRPQAKAAPRAYSDHDDRWETKEGAASPA 378
           + W +  K     +   Q         + +    +         + D+R   KE      
Sbjct: 467 EMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQ 526

Query: 379 PETPQPTSPETSPKETPMQPPEIPAPAHRPPEDEG----EENEGEEDEEWEDISEDEEEE 434
            +  Q        K+T  Q  +      +  E+E     E+   EE+E   +  E  +E+
Sbjct: 527 KKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQ 586

Query: 435 EIEVEEGDEEEPAQDHQAPE 454
           E ++ E +E+   Q+ +  E
Sbjct: 587 EEKMREQEEKMWEQEEKMQE 606



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 63/330 (19%), Positives = 125/330 (37%), Gaps = 35/330 (10%)

Query: 150 DRKSKEWEERRRQNIEKMNEEMEKIAEYERNQREGVLEPNPVRNFLDDPRRRSGPLEESE 209
           + + +E EE+  +  EKM E+ EK+   E    E   +       + D   R    +E  
Sbjct: 309 EEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERL 368

Query: 210 RDRREESRRHGRNWGG----PDFERVR---CGLEHERQGRRAGLGSAGDMTLSMTGRERS 262
           R++ E  R   + W       + ER+R     +  E +  R           +M  +E  
Sbjct: 369 REKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEK 428

Query: 263 EYLR----------WKQER-----EKI--DQERLQRHRKPTGQ----WRREWDAEKTDGM 301
           E+ +          W+QE+     EKI   +E+++   +  GQ    WR+E   E+ D M
Sbjct: 429 EWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQM 488

Query: 302 FKDGPVPAHEPSHRYDDQAWARPPKPPTFGEFLSQHKAEASSRRRRKSSRPQAKAAPRAY 361
           ++       E     + + W +  +     E L + +     +++      + +   +  
Sbjct: 489 WEQ-----EEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQ 543

Query: 362 SDHDDRWETKEGAASPAPETPQPTSPETSPKETPMQPPEIPAPAHRPPEDEGEENEGEED 421
                 W+ +E       E  +    +   +E  M+  E           E EE   E++
Sbjct: 544 EQEKKTWDQEEKMRE--EERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQE 601

Query: 422 EEWEDISEDEEEEEIEVEEGDEEEPAQDHQ 451
           E+ ++  E   E+E ++ E +EE+  Q+ +
Sbjct: 602 EKMQEQEEKMWEQEEKMWEQEEEDKMQEQE 631



 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 64/317 (20%), Positives = 114/317 (35%), Gaps = 67/317 (21%)

Query: 145 DTSISDRKSKEW--EERRRQNIEKMNEEMEKIAEYERNQREGVLEPNPVRNFLDDPRRRS 202
           +  I  ++ K W  EER R+   KM E+ EK+   E+  RE   E               
Sbjct: 247 EKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKE--------------- 291

Query: 203 GPLEESERDRREESRRHGRNWGGPDFERVRCGLEHERQGRRAGLGSAGDMTLSMTGRERS 262
             L E E++ RE+ +   +              E + Q +   +    +       RE+ 
Sbjct: 292 --LREQEKELREQKKLREQ--------------EEQMQEQEEKMWEQEEKM-----REQE 330

Query: 263 EYLRWKQEREKIDQERLQR--HRKPTGQWRREWDAEKTDGMFKDGPVPAHEPSHRYDDQA 320
           E + W+QE    +QE+  R   +K   Q  R W+        +D  +   E   R  ++ 
Sbjct: 331 EKM-WRQEERLWEQEKQMREQEQKMRDQEERMWE--------QDERLREKEERMREQEKM 381

Query: 321 WARPPKPPTFGEFLSQHKAEASSRRRRKSSRPQAKAAPRAYSDHDDRWETKEGAASPAPE 380
           W +  K         + +     ++ R+      +   +     ++ WE +E       E
Sbjct: 382 WEQEEK------MQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEE------KE 429

Query: 381 TPQPTSPETSPK---ETPMQPPEIPAPAHRPPEDEGEENEGEEDEEWEDISEDEEEEEI- 436
             Q   PE   K   +  MQ  E           + EE  G+E + W      E+E+++ 
Sbjct: 430 WQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMW 489

Query: 437 --EVEEGDEEEPAQDHQ 451
             E +  D+E+   D +
Sbjct: 490 EQEEKMRDQEQKMWDQE 506



 Score = 43.5 bits (101), Expect = 5e-04
 Identities = 59/311 (18%), Positives = 117/311 (37%), Gaps = 20/311 (6%)

Query: 150 DRKSKEWEERRRQNIEKMNEEMEKIAEYERNQREGVLEPNPVRNF-----LDDPRRRSGP 204
           ++K +E EE  R+  EKM ++ E + E E  + +    P           + +   +   
Sbjct: 398 EKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWE 457

Query: 205 LEESERDRREESRRHGRNWGGPDFERVRCGLEHERQGRRAGLGSAGDMTLSMTGRERSEY 264
            EE  RD+ E   +  + W           +  + +  R       D    M   E+ E 
Sbjct: 458 QEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMW--EQDER 515

Query: 265 LRWKQEREKID------QERLQRHRKPTGQWRREWDAEKTDGMFKDGPVPAHEPSHRYDD 318
           LR K+ER +        +E+++  +K   Q ++ WD E+   M ++  +   E   R ++
Sbjct: 516 LREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEK--MREEERMREREKKMREEE 573

Query: 319 QAWARPPKPPTFGEFLSQHKAEASSRRRRKSSRPQAKAAPRAYS----DHDDRWETKEGA 374
           +      +     E   + + E    +  K    + K   +       + +D+ + +E  
Sbjct: 574 EMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEM 633

Query: 375 ASPAPETPQPTSPETSPKETPMQPPEIPAPAHRPPEDEGEENEGEEDEEWEDISEDEEEE 434
                E  Q    +   +E  M+  E      +  + +G+E +  E EE     E++  E
Sbjct: 634 MWEQEEKMQEQEEKMWEQEEKMREQE-EKMREQEEKMQGQEEKMREQEEKMQGQEEKMRE 692

Query: 435 EIEVEEGDEEE 445
           + E   G EE+
Sbjct: 693 QEEKMRGQEEK 703



 Score = 38.9 bits (89), Expect = 0.012
 Identities = 78/467 (16%), Positives = 162/467 (34%), Gaps = 82/467 (17%)

Query: 7   LKSKEEKDAELDKRIEALRRKNEALIRRYQEIEEDRKKAELEGVAVTAPRKGRSVEKENV 66
           L+ KEE+  E +K  E      E  ++  + I E  KK   E   +    +    ++EN+
Sbjct: 368 LREKEERMREQEKMWE-----QEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENM 422

Query: 67  AVESEKNLGPSRRSPGTPRPPGASKGGRTPPQQGGRAGMGRASRSWEGSP---GEQPRGG 123
             + EK     R       P    K       Q       +  + WE       ++   G
Sbjct: 423 WEQEEKEWQQQRL------PEQKEKLWEQEKMQE------QEEKIWEQEEKIRDQEEMWG 470

Query: 124 GAGGRGRRGRGRGSPHLSGAGDTSISDRKSKEWEERRRQNIEKMNEEMEKIAEYERNQRE 183
                 R+ + R         +  + D++ K W++      E+M E+ E++ E E   RE
Sbjct: 471 QEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQE-----ERMWEQDERLREKEERMRE 525

Query: 184 GVLEPNPVRNFLDDPRRRSGPLEESERDRREESRRHGRNWGGPDFERVRCGLEHERQGRR 243
                          +++    EE  R+ ++   +  + W   +  R     E   + R 
Sbjct: 526 ---------------QKKMWQQEEKMREEKKTQEQEKKTWDQEEKMRE----EERMRERE 566

Query: 244 AGLGSAGDMTLSMTGRERSEYLRWKQEREKIDQERLQRHRKPTGQWRRE---WDAEKTDG 300
             +    +M      + + +  + +++ EK+ ++  +   +    W +E   W+ E+ D 
Sbjct: 567 KKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDK 626

Query: 301 MFKDGPVPAHEPSHRYDDQAWARPPKPPTFGEFLSQHKAEASSRRRRKSSRPQAKAAPRA 360
           M               ++  W +  K         Q + E    +  K    + K     
Sbjct: 627 M------------QEQEEMMWEQEEK--------MQEQEEKMWEQEEKMREQEEKMR--- 663

Query: 361 YSDHDDRWETKEGAASPAPETPQPTSPETSPKETPMQPPEIPAPAHRPPEDEGEENEGEE 420
             + +++ + +E       E  Q    +   +E  M+  E           + E+  G+E
Sbjct: 664 --EQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQE------EKMWGQEEKMWGQE 715

Query: 421 DEEWEDISEDEEEEEIEVEEGDEEEPAQDHQ----APEAAPTGIPCS 463
           ++ W      E+EE I  ++   +E   +H+     P   P+ + C+
Sbjct: 716 EKMWGQEEMREKEERIRDQKEKMQERLPEHEERCSEPCLPPSKVLCN 762



 Score = 35.0 bits (79), Expect = 0.17
 Identities = 35/188 (18%), Positives = 71/188 (37%), Gaps = 15/188 (7%)

Query: 267 WKQEREKIDQERLQRHRKPTGQWRREWDAEKTDGMFKDGPVPAHEPSHRYDDQAWARPPK 326
           W+QE E  +QE+  R ++    WR+E    + +G  ++          R  +Q       
Sbjct: 237 WRQEEELREQEKKIRKQEEK-MWRQEERLREQEGKMREQEEKMRRQEKRLREQE------ 289

Query: 327 PPTFGEFLSQHKAEASSRRRRKSSRPQAKAAPRAYSDHDDRWETKEGAASPAPETPQPTS 386
                + L + + E   +++ +    Q +       + +++   +E       E      
Sbjct: 290 -----KELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQE 344

Query: 387 PETSPKETPMQPPEIPAPAHRPPEDEGEENEGEEDEEWEDISEDEEEEEIEVEE---GDE 443
            +   +E  M+  E           E EE   E+++ WE   + +EEE I   E    +E
Sbjct: 345 KQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREE 404

Query: 444 EEPAQDHQ 451
           EE  ++ +
Sbjct: 405 EETMREQE 412


>gi|17975763 myelin transcription factor 1 [Homo sapiens]
          Length = 1121

 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 41/109 (37%), Positives = 58/109 (53%), Gaps = 5/109 (4%)

Query: 384 PTSPETSPKETPMQPPEIPAPAHRPPEDEGEENEGEEDEEWEDISEDEEEEEIEVEEGDE 443
           P S E +  E   +   I +      E+E EE E EEDEE E+  E+EEEEE E EE +E
Sbjct: 237 PQSLEDAASEESSKQKGILSHEEEDEEEEEEEEEEEEDEEEEE-EEEEEEEEEEEEEEEE 295

Query: 444 EEPAQDHQAPEAAPTGIPCSEQAH-GVPFSPEEPLLEPQAPGTPSSPFS 491
           EE  ++ +  EAAP  I   + +H     +PE  L  P++P +P   +S
Sbjct: 296 EEEEEEEEEEEAAPDVIFQEDTSHTSAQKAPE--LRGPESP-SPKPEYS 341



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 43/153 (28%), Positives = 62/153 (40%), Gaps = 15/153 (9%)

Query: 369 ETKEGAASPA--------PETPQPTSPETSPKETPMQPPEIP-APAHRPPEDEGEENEGE 419
           E  EGAAS          PE  +     T+ +   + P  +  A +    + +G  +  E
Sbjct: 200 EAAEGAASEEGEKGLFIQPEDAEEVVEVTTERSQDLCPQSLEDAASEESSKQKGILSHEE 259

Query: 420 EDEEWEDISEDEEE--EEIEVEEGDEEEPAQDHQAPEAAPTGIPCSEQAHGVPFSPEEPL 477
           EDEE E+  E+EEE  EE E EE +EEE  ++ +  E         E A  V F  +   
Sbjct: 260 EDEEEEEEEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEAAPDVIFQEDTSH 319

Query: 478 LEPQAPGTPSSPFSPPSGHQPVSDWGEEVELNS 510
              Q       P SP     P  ++   VE+ S
Sbjct: 320 TSAQKAPELRGPESP----SPKPEYSVIVEVRS 348



 Score = 30.0 bits (66), Expect = 5.5
 Identities = 26/112 (23%), Positives = 42/112 (37%), Gaps = 6/112 (5%)

Query: 358 PRAYSDHDDRWETKEGAASPAPETPQPTSPETSPKETPMQPPEIPAPAHRPPEDEGEENE 417
           P++  D      +K+       E  +    E   +E   +  E         E+E EE E
Sbjct: 237 PQSLEDAASEESSKQKGILSHEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEEEEEEEEEE 296

Query: 418 GEEDEEWEDISEDEEEEEIEVEEGDEEEPAQDHQAPEAAPTGIPCSEQAHGV 469
            EE+EE     E+E   ++  +E      AQ  +APE      P  +  + V
Sbjct: 297 EEEEEE----EEEEAAPDVIFQEDTSHTSAQ--KAPELRGPESPSPKPEYSV 342


>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
          Length = 2400

 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 111/519 (21%), Positives = 171/519 (32%), Gaps = 56/519 (10%)

Query: 41   DRKKAELEGV-AVTAPRKGRSVEKENVAVESEKNLGPSRRSPGTPRPPGASKGGRTPPQQ 99
            D+   + +G   + AP      + E+  VE+ +  G ++ + G  +P   S+    P  +
Sbjct: 1823 DQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPE--SEDVEAPEAE 1880

Query: 100  GGRAGMGRASRSWEGSPGEQPRGGGAGGRGRRGRGRGSPHLSGAGDTSISDRKSKEWEER 159
            G          + E     QP   GA         +       A +T   D    E  E 
Sbjct: 1881 GEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEA 1940

Query: 160  RR-----QNIEKMNEEMEKIAEYERNQREGVLEPNPVRNFLDDPRRRSGPLEESERDRRE 214
            +      Q  E   +   ++ E +  + E   E   V             +E   ++   
Sbjct: 1941 QEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEAL---------EVEVETQEAEG 1991

Query: 215  ESRRHGRNWGGPDFERVRCGLEHERQGRRAGLGSAGDMTLSMTGRERSEYLRWKQEREKI 274
            E++    +   P+ E      E E Q    G+    +      G E  E     Q+ E  
Sbjct: 1992 EAQPESEDVEAPEAEGEMQEAEEEAQPESDGV----EAQPKSEGEEAQEVEGETQKTEGD 2047

Query: 275  DQERLQRHRKPTGQWRREWDAEKTDGMFKDGPVPAHEPSHRYDDQAWARPPKPPTFGEFL 334
             Q        P      E +A++ +G  ++    AH  S   D Q      +P + G   
Sbjct: 2048 AQPESDGVEAPEA----EEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEA 2103

Query: 335  SQHKAEASSRRRRKSSRPQAKA--------APRAYSDHDDRWE-----TKEGAASPAPE- 380
             + + EA      ++   + +A        AP A  +     E       EG A P  E 
Sbjct: 2104 PEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEG 2163

Query: 381  -TPQPTSPETSPKETPMQPPEIPAPAHRPPEDEG---EENEGEEDEEWEDISEDEEEEEI 436
               Q    E  P+   ++ PE    A   PE EG    E EGE   E E +   E EEE 
Sbjct: 2164 IEAQEAEEEAQPELEGVEAPEAEGEAQ--PESEGIEAPEAEGEAQPELEGVEAPEAEEEA 2221

Query: 437  EVE-EGDEEEPAQDHQAPEA--APTGIPCSEQAHGVPFSPEEPLLEPQAPGTPSSPFSPP 493
            + E EG E   A+    PE+     G         +     E   E  +P     P  PP
Sbjct: 2222 QPEPEGVETPEAEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVPEDRPTPPP 2281

Query: 494  S--GHQPVSDWGEEVELNSPRTTHLAGALSPGEAWPFES 530
            S  G  P    G +   +S R      A S G  W  +S
Sbjct: 2282 SPGGDTPHQRPGSQTGPSSSR------ASSWGNCWQKDS 2314



 Score = 53.9 bits (128), Expect = 4e-07
 Identities = 103/494 (20%), Positives = 166/494 (33%), Gaps = 62/494 (12%)

Query: 39   EEDRKKAELEGVAVTAPRKGRSVEKENVAVESEKNLGPSRRSPGTPRPPGASKGGRTPPQ 98
            ++D K  E EG A+   R+G++   E  A      LG + +        G S+ G T  Q
Sbjct: 1755 DKDPKLGEAEGDAMAQEREGKTHNSETSA---GSELGEAEQEG-----EGISERGETGGQ 1806

Query: 99   QGGRAG--MGRASRSWEGSPGEQPRGGGAGGRGRRGRGRGSPHLSGAGDTSISDRKSKEW 156
              G      G A+   +  PG+    G  G       G   P   G            E 
Sbjct: 1807 GSGHEDNLQGEAAAGGDQDPGQSD--GAEGIEAPEAEGEAQPESEGV-----------EA 1853

Query: 157  EERRRQNIEKMNEEMEKIAEYERNQREGVLEPNPVRNFLDDPRRRSGPLEESERDRREES 216
             E      E   E   +  + E  + EG  E  P    ++ P        ESE     E+
Sbjct: 1854 PEAEGDAQEAEGEAQPESEDVEAPEAEG--EAQPESEDVETPEAEWEVQPESEGAEAPEA 1911

Query: 217  RRHGRNWGGPDFERVRCGLEHERQGRRAGLGSAGDMTLSMTGRERSEYLRWKQEREKIDQ 276
             +  +    P+ E V   LE E +      G+                    QE E+  Q
Sbjct: 1912 EKEAQ----PETESVEA-LETEGEDEPESEGAEA------------------QEAEEAAQ 1948

Query: 277  ERLQRHRKPTGQWRREWDAEKTDGMFKDGPVPAHEPSHRYDDQAWARPPKPPTFGEFLSQ 336
            E  +   +P  +     +AE+ +   +   V A E      +      P+     E +  
Sbjct: 1949 EA-EGQTQPESEVIESQEAEE-EAQPESEDVEALEVEVETQEAEGEAQPE----SEDVEA 2002

Query: 337  HKAEASSRRRRKSSRPQAKAAPRAYSDHDDRWETKEGAASPAPETPQPTSPETSPKETPM 396
             +AE   +   + ++P++           +  +  EG      +T     PE+   E P 
Sbjct: 2003 PEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQ---KTEGDAQPESDGVEAPE 2059

Query: 397  QPPEIPAPAHRPPEDEGEENEGEEDEEWEDISEDEEEEEIEVEEGDEEEPAQDHQAPEAA 456
               E         E EGE +   ED + ++   + + E   VE  + E  AQ  +  EA 
Sbjct: 2060 AEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAP 2119

Query: 457  PTGIPCSEQAHGVPFSPEEPLLEPQAPGTPSSPFSPPSGHQPVSDWGEEVELNSPRTTHL 516
             T      ++ G+     E   +P++ G  +      +  QP S+  E  E        L
Sbjct: 2120 ETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEA--QPESEGIEAQEAEEEAQPEL 2177

Query: 517  AGALSP---GEAWP 527
             G  +P   GEA P
Sbjct: 2178 EGVEAPEAEGEAQP 2191



 Score = 33.9 bits (76), Expect = 0.38
 Identities = 35/142 (24%), Positives = 56/142 (39%), Gaps = 6/142 (4%)

Query: 335  SQHKAEASSRRRRKSSRPQAKAAPRAYSDHDDRWETKEGAASPAPETPQPTSPETSPKET 394
            ++ +AE  S  +R SS  + + A     +     ETKEG      +       ET  +E 
Sbjct: 1272 NEDEAERDSEEQRASSNLE-QLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEG 1330

Query: 395  PMQPPEIPAPAHRPPEDEGEENEGEEDEEWEDISEDEEEEE----IEVEEGDEEEPAQDH 450
             +Q   +     +  E EG++ E  + EE E+   +  +EE     EV+EG E     + 
Sbjct: 1331 -LQEEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGEA 1389

Query: 451  QAPEAAPTGIPCSEQAHGVPFS 472
                    G+P     HG   S
Sbjct: 1390 LEEGLKEEGLPEEGSVHGQELS 1411


>gi|55956788 nucleolin [Homo sapiens]
          Length = 710

 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 31/98 (31%), Positives = 52/98 (53%), Gaps = 2/98 (2%)

Query: 354 AKAAPRAYSDHDDRWETKEGAASPAPETPQPTSPETSPKETPMQPPEIPAPAHRPPEDEG 413
           A AAP +  + D+  E  E       +  +  + ET+P +       +P  A    EDE 
Sbjct: 178 AAAAPASEDEDDEDDEDDEDDDDDEEDDSEEEAMETTPAKGKKAAKVVPVKAKNVAEDED 237

Query: 414 EE--NEGEEDEEWEDISEDEEEEEIEVEEGDEEEPAQD 449
           EE  +E E+D++ ED  +D++E++ E EE +EEEP ++
Sbjct: 238 EEEDDEDEDDDDDEDDEDDDDEDDEEEEEEEEEEPVKE 275



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 46/177 (25%), Positives = 73/177 (41%), Gaps = 15/177 (8%)

Query: 295 AEKTDGMFKDGPVPAHEPSHRYDDQAWARPPKPPTFGEFL----SQHKAEASSRRRRKSS 350
           A K  G  K    P  E     +D+  +   +  + GE +     + K  A++  ++   
Sbjct: 7   AGKNQGDPKKMAPPPKEVEEDSEDEEMSEDEEDDSSGEEVVIPQKKGKKAAATSAKKVVV 66

Query: 351 RPQAKAAPRAYSDHDDRWETKEGAASPAPETPQPTSPETSPKETPMQPPEI--------- 401
            P  K A    +        K+ AA+PA +T  P    T+P +    P +          
Sbjct: 67  SPTKKVAVATPAKKAAVTPGKKAAATPAKKTVTPAKAVTTPGKKGATPGKALVATPGKKG 126

Query: 402 -PAPAHRPPEDEGEENEGEEDEEWEDISEDEEEEEIEVEEGDEEEPAQDHQAPEAAP 457
              PA      +  + E  ++EE +D  EDEE++E E E+ DE EPA   +A  AAP
Sbjct: 127 AAIPAKGAKNGKNAKKEDSDEEEDDDSEEDEEDDEDEDEDEDEIEPAA-MKAAAAAP 182



 Score = 37.0 bits (84), Expect = 0.045
 Identities = 20/78 (25%), Positives = 37/78 (47%), Gaps = 5/78 (6%)

Query: 380 ETPQPTSPETSPKETPMQPPEIPAPAHRPPEDEGEENEGEEDEEWEDISEDEEEEEIEVE 439
           E  +    +    E  ++P  + A A  P  ++ ++ + E+DE+ +D  ED+ E     E
Sbjct: 154 EEDEEDDEDEDEDEDEIEPAAMKAAAAAPASEDEDDEDDEDDEDDDDDEEDDSE-----E 208

Query: 440 EGDEEEPAQDHQAPEAAP 457
           E  E  PA+  +A +  P
Sbjct: 209 EAMETTPAKGKKAAKVVP 226



 Score = 33.1 bits (74), Expect = 0.65
 Identities = 22/62 (35%), Positives = 27/62 (43%), Gaps = 3/62 (4%)

Query: 96  PPQQGGRAGMGRASRSWEGSPGEQPRGGGAGGRGR---RGRGRGSPHLSGAGDTSISDRK 152
           P  +GG  G G     + G  G +   GG GGRGR    GRG       G GD     +K
Sbjct: 647 PKGEGGFGGRGGGRGGFGGRGGGRGGRGGFGGRGRGGFGGRGGFRGGRGGGGDHKPQGKK 706

Query: 153 SK 154
           +K
Sbjct: 707 TK 708


>gi|155030232 proline, glutamic acid and leucine rich protein 1 [Homo
            sapiens]
          Length = 1130

 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 57/200 (28%), Positives = 73/200 (36%), Gaps = 56/200 (28%)

Query: 369  ETKEGAASPAPETPQPTSPETSPKETPMQPPEIPAPAHRP-------------------- 408
            E +E  A+P P  P P  P   P    + PP++  P   P                    
Sbjct: 828  EPEELPAAPGPLPPPPPPPPPVPGPVTLPPPQL-VPEGTPGGGGPPALEEDLTVININSS 886

Query: 409  -----PEDEGEENEGEEDEEWEDISEDEE----------------EEEIEVEEG--DEEE 445
                  E+E EE E EE+EE ED  E+EE                EEE E EEG  +EEE
Sbjct: 887  DEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGELEEEE 946

Query: 446  PAQDHQAPEAAPT------GIPCSEQAHGVPFSPEEPLLEPQAPGTPSSPFSPPSGHQPV 499
              +D +  E          G    E   G   +P  P L P  P   S P   P   +P 
Sbjct: 947  EEEDEEEEEELEEVEDLEFGTAGGEVEEG---APPPPTLPPALPPPESPPKVQP---EPE 1000

Query: 500  SDWGEEVELNSPRTTHLAGA 519
             + G  +E+  P T    GA
Sbjct: 1001 PEPGLLLEVEEPGTEEERGA 1020



 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 45/132 (34%), Positives = 55/132 (41%), Gaps = 11/132 (8%)

Query: 362  SDHDDRWETKEGAASPAPETPQPTSPETSPKETPMQPPEIPAPAHRPPEDEGEENEGEED 421
            SD ++  E +E       E  +    E    E      E         E E EE E EE+
Sbjct: 886  SDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGELEEE 945

Query: 422  EEWEDISEDEEEEEIEVEE-----GDEEEPAQDHQAPEAAPTGIPCSEQAHGVPFSPE-E 475
            EE ED  E+EE EE+E  E     G+ EE A     P   P  +P  E    V   PE E
Sbjct: 946  EEEEDEEEEEELEEVEDLEFGTAGGEVEEGA---PPPPTLPPALPPPESPPKVQPEPEPE 1002

Query: 476  P--LLEPQAPGT 485
            P  LLE + PGT
Sbjct: 1003 PGLLLEVEEPGT 1014



 Score = 38.1 bits (87), Expect = 0.020
 Identities = 57/212 (26%), Positives = 77/212 (36%), Gaps = 24/212 (11%)

Query: 306 PVPAHEPSHRYDDQAWARPPKPPTFGEFLSQHKAEASSRRRRKSSRPQAKAAPRAYSDHD 365
           PVP  E    +    +  P   P+ G   S     ++         P A+  P   ++H 
Sbjct: 650 PVPPPEAPSPFRAPPFHPPGPMPSVGSMPSAGPMPSAGPMPSAGPVPSARPGPPTTANHL 709

Query: 366 DRWETKEGAAS------PAPETPQPTS---PETSPKETPMQPPEIPAP---AHRPPEDEG 413
               +  G  S      P PE  +  S   P  +P  TP  PP IP       R P    
Sbjct: 710 GL--SVPGLVSVPPRLLPGPENHRAGSNEDPILAPSGTP--PPTIPPDETFGGRVPRPAF 765

Query: 414 EENEGEEDEEWE-DISEDEEEEEIEVEEGDEE---EPAQDHQAPEAAPTGIPCSEQAHGV 469
              + EE  + E  +  D ++  + V EG       P      P  APTG P +     V
Sbjct: 766 VHYDKEEASDVEISLESDSDDSVVIVPEGLPPLPPPPPSGATPPPIAPTGPPTASPP--V 823

Query: 470 PFSPEEPLLEPQAPG-TPSSPFSPPSGHQPVS 500
           P + EEP   P APG  P  P  PP    PV+
Sbjct: 824 P-AKEEPEELPAAPGPLPPPPPPPPPVPGPVT 854



 Score = 31.6 bits (70), Expect = 1.9
 Identities = 17/38 (44%), Positives = 19/38 (50%), Gaps = 3/38 (7%)

Query: 374 AASPAPETP--QPTSPETSPKETPMQPPEIPAPAHRPP 409
           AA   P  P  QP  P T P   P+ PPE P+P   PP
Sbjct: 628 AALTHPRVPPLQPMGP-TCPTPAPVPPPEAPSPFRAPP 664



 Score = 31.6 bits (70), Expect = 1.9
 Identities = 50/230 (21%), Positives = 80/230 (34%), Gaps = 30/230 (13%)

Query: 260  ERSEYLRWKQEREKIDQERLQRHRKPTGQWRREWDAEKTDGMFKDGPVPAHEPSHRYDDQ 319
            +  EY   ++E E+  +E  +       +   E D E+ + + +   +         ++ 
Sbjct: 916  DEEEYFEEEEEEEEEFEEEFEEEEGELEEEEEEEDEEEEEELEEVEDLEFGTAGGEVEEG 975

Query: 320  AWARPPKPPTFGEFLSQHKAEASSRRRRKSSRPQAKAAPRAYSDHDDRWETKEGAASPAP 379
            A   P  PP      S  K +           P+ +  P    + ++    +E  A  AP
Sbjct: 976  APPPPTLPPALPPPESPPKVQ-----------PEPEPEPGLLLEVEEPGTEEERGADTAP 1024

Query: 380  ETPQPTSPETSPKETPMQPPEIPAPAHRPPEDEGEENEGEE----DEEWEDISED----- 430
                  +PE  P +  ++       A  PP++  EE         +EE ED S+      
Sbjct: 1025 TL----APEALPSQGEVEREGESPAAGPPPQELVEEEPSAPPTLLEEETEDGSDKVQPPP 1080

Query: 431  ----EEEEEIEVEEGDEEEPAQDHQAPEAAPTGIPCSEQAHGVPFSPEEP 476
                EEE E E E    +E  QD  A   A   I C       P  P EP
Sbjct: 1081 ETPAEEEMETETEAEALQEKEQDDTAAMLADF-IDCPPDDEKPP-PPTEP 1128


>gi|100816397 MYST histone acetyltransferase (monocytic leukemia) 4
            [Homo sapiens]
          Length = 2073

 Score = 53.9 bits (128), Expect = 4e-07
 Identities = 91/408 (22%), Positives = 151/408 (37%), Gaps = 95/408 (23%)

Query: 149  SDRKSKEWEERRRQNIEKMNEEMEKIAEYERNQREGVLEPNPVRNFLDDPR----RRSGP 204
            S+ + +E +E   +  E+  E+ E+  E E  + E  ++ +P R  L  P+    +R  P
Sbjct: 1069 SEEEEEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEENIQSSPPR--LTKPQSVAIKRKRP 1126

Query: 205  LEESERDRREESRRHG---------------RNWGGPDFERVR------CGLEHERQGRR 243
                ++  R+  R +                  +   D ER        C +E E  GR+
Sbjct: 1127 FVLKKKRGRKRRRINSSVTTETISETTEVLNEPFDNSDEERPMPQLEPTCEIEVEEDGRK 1186

Query: 244  AGLGSAGDMTLSMTGRERSEYLRWKQEREKIDQERLQRHRKPTGQWRREWDAEKTDGMFK 303
              L  A        G++R      + E E+       ++  P      +  +   +G  K
Sbjct: 1187 PVLRKAFQ---HQPGKKR------QTEEEEGKDNHCFKNADPCRNNMNDDSSNLKEGS-K 1236

Query: 304  DGPVPAHEPSHRYDDQAWARPPKPPTFGEFLSQHKAEASSRRRRKSSRPQAKAAPRAYSD 363
            D P P          Q W +  K         Q+K   +  +    + P+    P     
Sbjct: 1237 DNPEPLK------CKQVWPKGTKRGL--SKWRQNKERKTGFKLNLYTPPETPMEPDEQVT 1288

Query: 364  HDDRWETKEGAASPAP-----------------------ETPQPTSPETSPKETP---MQ 397
             +++ ET EG  SP+P                       ET  P SP TSP E P   + 
Sbjct: 1289 VEEQKETSEGKTSPSPIRIEEEVKETGEALLPQEENRREETCAPVSPNTSPGEKPEDDLI 1348

Query: 398  PPEIPAPAHRPPEDEGEENEGEEDEEWEDI--------SEDEEEEEI------------- 436
             PE         E+E EE EGEE+E   ++        S+++EE EI             
Sbjct: 1349 KPEEEEEEEEEEEEEEEEEEGEEEEGGGNVEKDPDGAKSQEKEEPEISTEKEDSARLDDH 1408

Query: 437  EVEEGDEEEPA--QDHQAPEAAPTGIPCSE-QAHGVPFSPEEPLLEPQ 481
            E EE ++EEP+  +DH A +   + +  +E +   +P    + +LE Q
Sbjct: 1409 EEEEEEDEEPSHNEDHDADDEDDSHMESAEVEKEELPRESFKEVLENQ 1456



 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 29/91 (31%), Positives = 43/91 (47%), Gaps = 6/91 (6%)

Query: 368  WETKEGAASPAPETPQPTSPETSPKETPMQPPEI-PAPAHRPP-----EDEGEENEGEED 421
            WE +E          + +  +   K   +  PE  P    R       ++  EE E EED
Sbjct: 1018 WEKEEQEILSTRANSRQSPAKVQSKNKYLHSPESRPVTGERGQLLELSKESSEEEEEEED 1077

Query: 422  EEWEDISEDEEEEEIEVEEGDEEEPAQDHQA 452
            EE E+  E+EEE+E E EE +EEE  ++ Q+
Sbjct: 1078 EEEEEEEEEEEEDEEEEEEEEEEEEEENIQS 1108



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 25/76 (32%), Positives = 41/76 (53%), Gaps = 8/76 (10%)

Query: 390  SPKETPMQPPEIPAPAHRPPEDEG--------EENEGEEDEEWEDISEDEEEEEIEVEEG 441
            SP +   +   + +P  RP   E         E +E EE+EE E+  E+EEEEE + EE 
Sbjct: 1035 SPAKVQSKNKYLHSPESRPVTGERGQLLELSKESSEEEEEEEDEEEEEEEEEEEEDEEEE 1094

Query: 442  DEEEPAQDHQAPEAAP 457
            +EEE  ++ +  +++P
Sbjct: 1095 EEEEEEEEEENIQSSP 1110



 Score = 33.1 bits (74), Expect = 0.65
 Identities = 98/512 (19%), Positives = 160/512 (31%), Gaps = 130/512 (25%)

Query: 37   EIEEDRKKAELEGVAVTAPRKGRSVEKENVAVES-EKNLGPSRRSPGTPRPPGASKGGRT 95
            E+EED +K  L       P K R  E+E        KN  P R +          +G + 
Sbjct: 1179 EVEEDGRKPVLRKAFQHQPGKKRQTEEEEGKDNHCFKNADPCRNNMNDDSS-NLKEGSKD 1237

Query: 96   PPQQGGRAGMGRASRSWEGSPGEQPRGGGAG-GRGRRGRGRGS---------PHLSGAGD 145
             P+        +  + W       P+G   G  + R+ + R +         P      D
Sbjct: 1238 NPEPL------KCKQVW-------PKGTKRGLSKWRQNKERKTGFKLNLYTPPETPMEPD 1284

Query: 146  TSISDRKSKEWEERRRQNI-----EKMNEEMEKIAEYERNQREGVLEP-----NPVRNFL 195
              ++  + KE  E +         E++ E  E +   E N+RE    P     +P     
Sbjct: 1285 EQVTVEEQKETSEGKTSPSPIRIEEEVKETGEALLPQEENRREETCAPVSPNTSPGEKPE 1344

Query: 196  DDPRRRSGPLEESERDRREESRRHGRNWGGPDFERVRCGLEHERQGRRAGLGSAGDMTLS 255
            DD  +     EE E +  EE    G               E E  G        G++   
Sbjct: 1345 DDLIKPEEEEEEEEEEEEEEEEEEG---------------EEEEGG--------GNVEKD 1381

Query: 256  MTGRERSEYLRWKQEREKIDQERLQRHRKPTGQWRREWDAEKTDGMFKDGPVPAHEPSHR 315
              G +  E    +   EK D  RL  H +       E D E           P+H   H 
Sbjct: 1382 PDGAKSQEKEEPEISTEKEDSARLDDHEE-----EEEEDEE-----------PSHNEDHD 1425

Query: 316  YDDQAWARPPKPPTFGEFLSQHKAEASSRRRRKSSRPQAKAAPRAYSDHDDRWETKEGAA 375
             DD+            +      AE       + S  +       + D +     + G +
Sbjct: 1426 ADDE------------DDSHMESAEVEKEELPRESFKEVLENQETFLDLN----VQPGHS 1469

Query: 376  SPAP----ETPQPTSPETSPKETPMQPPEIPAPAHRPP-----EDEGEENEGEEDEEWE- 425
            +P            S  + PKE    P  +P     PP     + + ++N  E D E++ 
Sbjct: 1470 NPEVLMDCGVDLTASCNSEPKELAGDPEAVPESDEEPPPGEQAQKQDQKNSKEVDTEFKE 1529

Query: 426  --------DISEDEEEEEIEVEEGDEEEPAQD-----------------HQAPEAAPTGI 460
                    D    +  + +  E  ++++  QD                  Q+P+ A T  
Sbjct: 1530 GNPATMEIDSETVQAVQSLTQESSEQDDTFQDCAETQEACRSLQNYTRADQSPQIATTLD 1589

Query: 461  PCSEQAHGVPFS-----PEEPLLEPQAPGTPS 487
             C +  H  P S     P + +    +P  P+
Sbjct: 1590 DCQQSDHSSPVSSVHSHPGQSVRSVNSPSVPA 1621


>gi|30795231 brain abundant, membrane attached signal protein 1
           [Homo sapiens]
          Length = 227

 Score = 53.5 bits (127), Expect = 5e-07
 Identities = 42/155 (27%), Positives = 69/155 (44%), Gaps = 12/155 (7%)

Query: 359 RAYSDHDDRWETKEGAASPAPETPQPTSPETSPKETPMQPPEIPAPAHRPPEDEGEENEG 418
           + Y+ +D++ + K+  A  A      T  E +PKE+  Q    PA A    E   ++ EG
Sbjct: 10  KGYNVNDEKAKEKDKKAEGAA-----TEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEG 64

Query: 419 EEDEEWEDISEDEEEEEIEVEEGDEEEPAQDHQAPE--AAPTGIPCSEQAHGVPFSPEEP 476
           + +E+     E E++     EE  + EP +   A E  A P   P  EQA   P +  E 
Sbjct: 65  KAEEK-----EGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEA 119

Query: 477 LLEPQAPGTPSSPFSPPSGHQPVSDWGEEVELNSP 511
               +A   P+   +P +G +P  + GE  +  +P
Sbjct: 120 PKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAP 154



 Score = 38.9 bits (89), Expect = 0.012
 Identities = 40/191 (20%), Positives = 66/191 (34%), Gaps = 9/191 (4%)

Query: 317 DDQAWARPPKPPTFGEFLSQH-KAEASSRRRRKSSRPQAKAAPRAYSDHDDRWETKEGAA 375
           + QA A P +     E   Q  + +A  +   K +    + AP+A  +  +     +   
Sbjct: 41  EPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEP 100

Query: 376 SPAPETPQPTSPETSPKETPMQPPEIPAPAHRPPEDEGEENEGEEDEEWEDISEDEEEEE 435
             APE  Q      +  E P       APA       GEE   EE E         ++ E
Sbjct: 101 PKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGE--------PKKTE 152

Query: 436 IEVEEGDEEEPAQDHQAPEAAPTGIPCSEQAHGVPFSPEEPLLEPQAPGTPSSPFSPPSG 495
                  +E  +    A ++ P     +  +   P + E P   P+A G  +S   P   
Sbjct: 153 APAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEEPKPV 212

Query: 496 HQPVSDWGEEV 506
             P ++  + V
Sbjct: 213 EAPAANSDQTV 223



 Score = 36.2 bits (82), Expect = 0.077
 Identities = 32/109 (29%), Positives = 45/109 (41%), Gaps = 10/109 (9%)

Query: 305 GPVPAHEPSHRYDDQAWARPPKPPTFGEFLSQHKAEASSRRRRKSSRPQAKAAPRAYSDH 364
           GP    E     +  A       P  GE  S+ + E      +K+  P A AA    SD 
Sbjct: 112 GPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEP-----KKTEAPAAPAAQETKSDG 166

Query: 365 DDRWETKEGAASPAP---ETPQPT-SPETSPK-ETPMQPPEIPAPAHRP 408
               ++K G++  AP   ETP  T +P ++PK + P    E P P   P
Sbjct: 167 APASDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEEPKPVEAP 215


>gi|221316599 chromogranin B precursor [Homo sapiens]
          Length = 677

 Score = 53.5 bits (127), Expect = 5e-07
 Identities = 68/329 (20%), Positives = 124/329 (37%), Gaps = 31/329 (9%)

Query: 108 ASRSWEGSPGEQPRGGGAGGRGRRGRGRGSPHLSGAGDTSIS-----DRKSKEWEERRRQ 162
           +SR   G+PGE+   G       +    G      A +   S      + S+E + R  +
Sbjct: 99  SSRGEAGAPGEEDIQGPTKADTEKWAEGGGHSRERADEPQWSLYPSDSQVSEEVKTRHSE 158

Query: 163 NIEKMNEEMEKIAEYERNQR-------EGVLEPNPVRNFLDDPRRRSGPLEESERDRREE 215
             ++ +EE E+   Y++ +R       + + EP   +N   + R+++  +++ E   R E
Sbjct: 159 KSQREDEEEEEGENYQKGERGEDSSEEKHLEEPGETQNAFLNERKQASAIKKEELVARSE 218

Query: 216 SRRHGRNWGGPDFERVRCGLEHERQGRRAG--LGSAGDMTLSMTGRERSEYLRWKQEREK 273
           +   G +      E+       E+  + +G   GS  +      G+ RS+     +E E+
Sbjct: 219 THAAGHSQ-----EKTH---SREKSSQESGEETGSQENHPQESKGQPRSQ-----EESEE 265

Query: 274 IDQERLQRHRKPTGQWRREWDAEKTDGMFKDGPVPAHEPSHRYDDQAWARPPKPPTFGEF 333
            +++      K   + R      + D   + G +P+ E  H  ++   +      + GE 
Sbjct: 266 GEEDATSEVDKRRTRPRHHHGRSRPDRSSQGGSLPSEEKGHPQEESEESNVSMA-SLGEK 324

Query: 334 LSQHKAEASSRRRRKSSRPQAKAAPRAYSDHDDRWETKEGAASPAPETPQPTSPETSPKE 393
              H     +         + K  P   +  D  WE   G  S     P+P S E+  +E
Sbjct: 325 RDHHSTHYRASEEEPEYGEEIKGYPGVQAPEDLEWERYRGRGSEEYRAPRPQSEESWDEE 384

Query: 394 TPMQPP--EIPAPAHRPPEDEGEENEGEE 420
                P  E+   AH   E E EE  G E
Sbjct: 385 DKRNYPSLELDKMAHGYGE-ESEEERGLE 412



 Score = 38.9 bits (89), Expect = 0.012
 Identities = 70/312 (22%), Positives = 111/312 (35%), Gaps = 69/312 (22%)

Query: 11  EEKDAELDKRIEALRRKNEALIRRYQEIEEDRKKAELEGVAVTAPRKGRSVE-------- 62
           E K A   K+ E + R         QE    R+K+  E    T  ++    E        
Sbjct: 201 ERKQASAIKKEELVARSETHAAGHSQEKTHSREKSSQESGEETGSQENHPQESKGQPRSQ 260

Query: 63  ------KENVAVESEKNLGPSRRSPGTPRPPGASKGGRTPPQQGGR------------AG 104
                 +E+   E +K     R   G  RP  +S+GG  P ++ G             A 
Sbjct: 261 EESEEGEEDATSEVDKRRTRPRHHHGRSRPDRSSQGGSLPSEEKGHPQEESEESNVSMAS 320

Query: 105 MG----------RASRSWEGSPGEQPRG-----GGAGGRGRRGRGRGSPHLSGAGDTSIS 149
           +G          RAS   E   GE+ +G             R RGRGS         S  
Sbjct: 321 LGEKRDHHSTHYRASEE-EPEYGEEIKGYPGVQAPEDLEWERYRGRGSEEYRAPRPQS-- 377

Query: 150 DRKSKEWEERRRQNIEKMNEEMEKIAE--YERNQREGVLEPNPVRN-----------FLD 196
               + W+E  ++N   +  E++K+A    E ++ E  LEP   R+           F+ 
Sbjct: 378 ---EESWDEEDKRNYPSL--ELDKMAHGYGEESEEERGLEPGKGRHHRGRGGEPRAYFMS 432

Query: 197 DPRRRSGPLEES----ERDRREESRRHGRNWGGPDFERVRCGLEHERQGRRAGLGSAGDM 252
           D R     L E     + ++ +++RRH +   G   E  R  L +  +G        GD+
Sbjct: 433 DTREEKRFLGEGHHRVQENQMDKARRHPQ---GAWKELDRNYLNYGEEGAPGKWQQQGDL 489

Query: 253 TLSMTGRERSEY 264
             +   RE + +
Sbjct: 490 QDTKENREEARF 501


>gi|60498973 myelin transcription factor 1-like [Homo sapiens]
          Length = 1184

 Score = 53.5 bits (127), Expect = 5e-07
 Identities = 34/116 (29%), Positives = 55/116 (47%), Gaps = 7/116 (6%)

Query: 342 SSRRRRKSSRPQAKA------APRAYSDHDDRWETKEGAASPAPETPQPTSPETSPKETP 395
           + +R+ +  +PQ  A      A +A S   D  +  +G      +        +   + P
Sbjct: 58  AKKRKTQDKQPQEPAPKRKPFAVKADSSSVDECDDSDGTEDMDEKEEDEGEEYSEDNDEP 117

Query: 396 MQPPEIPAPAHRPPEDEGEENEGEEDEEWEDISEDEEEEEIEVEEGDEEEPAQDHQ 451
               E      R  E+E EE + ++DE+ ED+ ++EEEEE E EE +EEE  +DHQ
Sbjct: 118 GDEDEEDEEGDREEEEEIEEEDEDDDEDGEDVEDEEEEEE-EEEEEEEEEENEDHQ 172



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 20/51 (39%), Positives = 30/51 (58%)

Query: 404 PAHRPPEDEGEENEGEEDEEWEDISEDEEEEEIEVEEGDEEEPAQDHQAPE 454
           P     EDE  + E EE+ E ED  +DE+ E++E EE +EEE  ++ +  E
Sbjct: 117 PGDEDEEDEEGDREEEEEIEEEDEDDDEDGEDVEDEEEEEEEEEEEEEEEE 167



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 29/98 (29%), Positives = 42/98 (42%), Gaps = 30/98 (30%)

Query: 387 PETSPKETPMQPPEIPAPAHRP-------------------------PEDEGEENEGEED 421
           P    ++T  + P+ PAP  +P                          EDEGEE   + D
Sbjct: 56  PLAKKRKTQDKQPQEPAPKRKPFAVKADSSSVDECDDSDGTEDMDEKEEDEGEEYSEDND 115

Query: 422 EEWEDISED-----EEEEEIEVEEGDEEEPAQDHQAPE 454
           E  ++  ED     EEEEEIE E+ D++E  +D +  E
Sbjct: 116 EPGDEDEEDEEGDREEEEEIEEEDEDDDEDGEDVEDEE 153


>gi|78042577 MAP7 domain containing 1 [Homo sapiens]
          Length = 841

 Score = 53.5 bits (127), Expect = 5e-07
 Identities = 46/171 (26%), Positives = 69/171 (40%), Gaps = 12/171 (7%)

Query: 335 SQHKAEASSRRRRKSSRPQAKAAPRAYSDHDDRWE----TKEGAASPAPETPQPTSPETS 390
           ++ +  A +R R    R    A+PRA        E    +K   +SP+    +P SP  S
Sbjct: 424 NEKEKSALARERSLKKRQSLPASPRARLSASTASELSPKSKARPSSPSTSWHRPASPCPS 483

Query: 391 PKETPMQPPEIPAPAHRPPEDEGEENEGEEDEEWEDISEDEEEEEIEVEEGDEEEPAQD- 449
           P      PP+ P+P       +G     EE +E    +  E++ + +    +E+E A   
Sbjct: 484 PGPGHTLPPKPPSPRGTTASPKGRVRRKEEAKESPSAAGPEDKSQSKRRASNEKESAAPA 543

Query: 450 HQAPEAAPTGIPCSEQAHGVPFSPEEP-----LLEPQAPGTPSSPFSPPSG 495
             AP  AP+  P   Q    P   E P     L  P AP  P +P  P +G
Sbjct: 544 SPAPSPAPSPTPAPPQKEQPP--AETPTDAAVLTSPPAPAPPVTPSKPMAG 592



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 79/367 (21%), Positives = 122/367 (33%), Gaps = 68/367 (18%)

Query: 90  SKGGRTPPQQGGRAGMGRASRSWEGSPGEQPRGGGAGGRGRRGRGRGSPHLSGAGDTSIS 149
           S+   T P+ G   G G         PG  P  G AG    RG      H S A    + 
Sbjct: 311 SRSAVTLPRNGRDQGRGC-------DPGRGPTWGRAGASLARGPQPDRTHPSAA--VPVC 361

Query: 150 DRKSKEWEERRRQNIEKMNEEMEKIAEYERNQREGVLEPNPVRNFLDDPRRRSGPLEESE 209
            R +             ++         ER +      P PVR      R  + P+++ E
Sbjct: 362 PRSASASPLTPCSVTRSVHRCAPAGERGERRKPNAGGSPAPVRR-----RPEASPVQKKE 416

Query: 210 RDRREESRRHGRNWGGPDFERVRCGLEHERQ-GRRAGLGSAGDMTLSMTGRERSEYLRWK 268
           +  +E              E+ +  L  ER   +R  L ++    LS +           
Sbjct: 417 KKDKEREN-----------EKEKSALARERSLKKRQSLPASPRARLSAS----------- 454

Query: 269 QEREKIDQERLQRHRKPTGQWRREWDAEKTDGMFKDGPVPAHEPSHRYDDQAWARPPKPP 328
               ++  +   R   P+  W R              P P+  P H         PPKPP
Sbjct: 455 -TASELSPKSKARPSSPSTSWHRP-----------ASPCPSPGPGHTL-------PPKPP 495

Query: 329 TFGEFLSQHKAEASSRRRRKSSRPQAKAAPRAYSDHDDRWETKEGAASPAPETPQPT-SP 387
           +     +  K     RR+ ++    + A P   S    R   ++ +A+PA   P P  SP
Sbjct: 496 SPRGTTASPKGRV--RRKEEAKESPSAAGPEDKSQSKRRASNEKESAAPASPAPSPAPSP 553

Query: 388 ETSPKETPMQPPEIPA--------PAHRPPEDEGEENEGEED-EEWEDISEDEEEEEIEV 438
             +P +    P E P         PA  PP    +   G  D EE   +  ++  +  E 
Sbjct: 554 TPAPPQKEQPPAETPTDAAVLTSPPAPAPPVTPSKPMAGTTDREEATRLLAEKRRQAREQ 613

Query: 439 EEGDEEE 445
            E +E+E
Sbjct: 614 REREEQE 620



 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 94/422 (22%), Positives = 151/422 (35%), Gaps = 71/422 (16%)

Query: 30  ALIRRYQEIEEDRKKAELEGVAVTAPRKGRSVEKENVAVESEKNLGPSRRSPGTPRPP-G 88
           A +RR  E    +KK + +        K R  EKE  A+  E++L   +  P +PR    
Sbjct: 401 APVRRRPEASPVQKKEKKD--------KERENEKEKSALARERSLKKRQSLPASPRARLS 452

Query: 89  ASKGGRTPPQQGGRAGMGRASRSWE------GSPG---------EQPRGGGAGGRG---R 130
           AS      P+   +A     S SW        SPG           PRG  A  +G   R
Sbjct: 453 ASTASELSPK--SKARPSSPSTSWHRPASPCPSPGPGHTLPPKPPSPRGTTASPKGRVRR 510

Query: 131 RGRGRGSPHLSGAGDTSISDRKSKEWEERRRQNIEKMNEEMEKIAEYERNQREGVLEPNP 190
           +   + SP  +G  D S S R++   +E         +          + ++     P  
Sbjct: 511 KEEAKESPSAAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQPPAETPTD 570

Query: 191 VRNFLDDPRRRSGPLEESE-----RDRRE------ESRRHGRNWGGPDFERVRCGLEHER 239
               L  P   + P+  S+      DR E      E RR  R     + +  R   E ++
Sbjct: 571 AA-VLTSPPAPAPPVTPSKPMAGTTDREEATRLLAEKRRQAREQREREEQERRLQAERDK 629

Query: 240 QGRRAGLGSAGDMTLSMTG---RERSEYLRWKQEREKIDQERLQRHRKPTGQWRREWDAE 296
           + R   L    +          R   +  R K + E+ +QERLQ+ ++      RE +AE
Sbjct: 630 RMREEQLAREAEARAEREAEARRREEQEAREKAQAEQEEQERLQKQKEEAEARSRE-EAE 688

Query: 297 KTDGMFKDGPVPAHEPSHRYDDQAWARPPKPPTFGEFLSQ-HKAEASSRRRRKSSR---- 351
           +             E    +  Q   R  +     E + +  K+E S  ++++ S+    
Sbjct: 689 R----------QRLEREKHFQQQEQERQERRKRLEEIMKRTRKSEVSETKQKQDSKEANA 738

Query: 352 ----PQAKAAPRAYSDHDDRWETKEGAASPAPETPQPTSPETSPKETPMQPPE--IPAPA 405
               P+   A  A S    +   ++    P P+ PQ + P    KE P        P PA
Sbjct: 739 NGSSPEPVKAVEARSPGLQKEAVQK--EEPIPQEPQWSLPS---KELPASLVNGLQPLPA 793

Query: 406 HR 407
           H+
Sbjct: 794 HQ 795



 Score = 30.8 bits (68), Expect = 3.2
 Identities = 20/85 (23%), Positives = 27/85 (31%), Gaps = 10/85 (11%)

Query: 325 PKPPTFGEFLSQHKAEASSRRRRKSSRPQAKAAPRAYSDHDDRWETKEGAASPAPETPQP 384
           P PP     +     +     +  +S  Q    P          E+  G   P P  PQ 
Sbjct: 35  PPPPPMSALVPDTPPDTPPAMKNATSSKQLPLEP----------ESPSGQVGPRPAPPQE 84

Query: 385 TSPETSPKETPMQPPEIPAPAHRPP 409
            SP +  K     PP +     RPP
Sbjct: 85  ESPSSEAKSRGPTPPAMGPRDARPP 109


>gi|33286446 opioid growth factor receptor [Homo sapiens]
          Length = 677

 Score = 53.1 bits (126), Expect = 6e-07
 Identities = 97/400 (24%), Positives = 133/400 (33%), Gaps = 55/400 (13%)

Query: 80  SPGTPRPPGASKGGRTPPQQ---GGRAGMGRASRSWE---GSPGEQPRGGGAGGRGRRGR 133
           SPG P    +++G    P+    GGR   G   RS E     P E+ +G  AGG G    
Sbjct: 315 SPGDPDHEASTQGRTCGPEHSKGGGRVDEGPQPRSVEPQDAGPLERSQGDEAGGHGEDRP 374

Query: 134 GRGSPHLSGAGDTSISDRKSKEWEE--RRRQNIEKMNEEMEKIAEYERNQREGVLEPNPV 191
              SP  S      +S R+    E   +    +EK+   +E  A  + + R G  E    
Sbjct: 375 EPLSPKESKKRKLELSRREQPPTEPGPQSASEVEKIALNLEGCALSQGSLRTGTQEVGG- 433

Query: 192 RNFLDDPRRRSGPLEESERDRREESRRHGRNWGGPDFERVRCGLEHERQGRRAGLGSAGD 251
                DP     P  +    R  +  R  R                E  G  A + S G 
Sbjct: 434 ----QDPGEAVQPCRQPLGARVADKVRKRRK-------------VDEGAGDSAAVASGGA 476

Query: 252 MTLSMTGRER-SEYLRWKQEREKIDQERLQRHRKPTGQWRREWDAEKTDGMFKDGPVPAH 310
            TL++ G    S + +       ++++   R     G         +T G    GP    
Sbjct: 477 QTLALAGSPAPSGHPKAGHSENGVEEDTEGRTGPKEGT---PGSPSETPGPSPAGPA-GD 532

Query: 311 EPSHRYDDQAWARPPKPPTFGEFLSQHKAEASSRRRRKSSRPQAKAAPRAYSDHDDRWET 370
           EP+    +    RP  P           AE+ S       RP   A        D+  E+
Sbjct: 533 EPAESPSETPGPRPAGPA------GDEPAESPSET--PGPRPAGPAG-------DEPAES 577

Query: 371 KEGAASPAPETPQPTSPETSPKETPMQPPEIPA---PAHRPPEDEGEENEGEE-DEEWED 426
                 P+P  P    P  SP ETP   P  PA   PA  P E  G    G   DE  E 
Sbjct: 578 PSETPGPSPAGPTRDEPAESPSETPGPRPAGPAGDEPAESPSETPGPRPAGPAGDEPAES 637

Query: 427 ISEDEEEEEI-----EVEEGDEEEPAQDHQAPEAAPTGIP 461
            SE            E  +  E    QD +   +A +G P
Sbjct: 638 PSETPGPSPAGPTRDEPAKAGEAAELQDAEVESSAKSGKP 677



 Score = 30.4 bits (67), Expect = 4.2
 Identities = 25/83 (30%), Positives = 33/83 (39%), Gaps = 10/83 (12%)

Query: 55  PRKGRSVEKENVAVESEKNLGPSRRSPGTP-RPPGASKGG-------RTPPQQGGRAGMG 106
           P+ G S  +  V  ++E   GP   +PG+P   PG S  G        +P +  G    G
Sbjct: 491 PKAGHS--ENGVEEDTEGRTGPKEGTPGSPSETPGPSPAGPAGDEPAESPSETPGPRPAG 548

Query: 107 RASRSWEGSPGEQPRGGGAGGRG 129
            A      SP E P    AG  G
Sbjct: 549 PAGDEPAESPSETPGPRPAGPAG 571


>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 899

 Score = 52.8 bits (125), Expect = 8e-07
 Identities = 58/305 (19%), Positives = 118/305 (38%), Gaps = 8/305 (2%)

Query: 150 DRKSKEWEERRRQNIEKMNEEMEKIAEYERNQREGVLEPNPVRNFLDDPRRRSGPLEESE 209
           + + +E EE+  +  EKM E+ EK+   E    E   +       + D   R    +E  
Sbjct: 347 EEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERL 406

Query: 210 RDRREESRRHGRNWGGPDFERVRCGLEHERQGRRAGLGSAGDMTLSMTGRERSEYLRWKQ 269
           R++ E  R   + W     E++R   + + Q ++        M      RER + +R ++
Sbjct: 407 REKEERMREQEKMW--EQVEKMREEKKMQEQEKKT-RDQEEKMQEEERIREREKKMREEE 463

Query: 270 EREKIDQERLQRHRKPT-GQWRREWDAEKTDGMFKDGPVPAHEPSHRYDDQAWARPPKPP 328
           E  +  +E++Q+  +    Q  +EW  ++     +   +   E     +++ W +  K  
Sbjct: 464 ETMREQEEKMQKQEENMWEQEEKEWQQQRLPE--QKEKLWEQEKMQEQEEKIWEQEEKIR 521

Query: 329 TFGEFLSQHKAEASSRRRRKSSRPQAKAAPRAYSDHDDRWETKEGAASPAPETPQPT--S 386
              E   Q K      + R+      +   +        W+ +E       E  + T   
Sbjct: 522 DQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQ 581

Query: 387 PETSPKETPMQPPEIPAPAHRPPEDEGEENEGEEDEEWEDISEDEEEEEIEVEEGDEEEP 446
            E   +E  M+  E           E EE   E++E+ ++  E   E+E +++E +E+  
Sbjct: 582 EEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMW 641

Query: 447 AQDHQ 451
            Q+ +
Sbjct: 642 EQEEK 646



 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 59/315 (18%), Positives = 121/315 (38%), Gaps = 31/315 (9%)

Query: 145 DTSISDRKSKEWE--ERRRQNIEKMNEEMEKIAEYERNQREGVLEPNPVRNFLDDPRRRS 202
           +  + +++ K WE  E+ R+  EKM  + E++ E E+  RE   +       + D   R 
Sbjct: 347 EEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQK-------MRDQEERM 399

Query: 203 GPLEESERDRREESRRHGRNWGGPDFERVRCGLEHERQGRRAGLGSAGDMTLSMTGRERS 262
              +E  R++ E  R   + W   +  R    ++ + +  R        M      RER 
Sbjct: 400 WEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTR---DQEEKMQEEERIRERE 456

Query: 263 EYLRWKQEREKIDQERLQRHRKPTG-QWRREWDAEKTDGMFKDGPVPAHEPSHRYDDQAW 321
           + +R ++E  +  +E++Q+  +    Q  +EW  ++     +   +   E     +++ W
Sbjct: 457 KKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEK--LWEQEKMQEQEEKIW 514

Query: 322 ARPPKPPTFGEFLSQHKAEASSRRRRKSSRPQAKAAPRAYSDHDDRWETKEGAASPAPET 381
            +  K     E   Q K      + R+      +   +        W+ +E       E 
Sbjct: 515 EQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQ 574

Query: 382 PQPT--SPETSPKETPMQPPEIPAPAHRPPEDEGEENEGEEDEEWEDISEDEEEEEIEVE 439
            + T    E   +E  M+              E E+   EE+E   +  E  +E+E +++
Sbjct: 575 EKKTWDQEEKMREEERMR--------------EREKKMREEEEMMREQEEKMQEQEEKMQ 620

Query: 440 EGDEEEPAQDHQAPE 454
           E +E+   Q+ +  E
Sbjct: 621 EQEEKMWEQEEKMQE 635



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 60/323 (18%), Positives = 118/323 (36%), Gaps = 26/323 (8%)

Query: 150 DRKSKEWEERRRQNIEKMNEEMEKIAEYERNQREGVLEPNPVRNFLDDPRRRSGPLEESE 209
           D + +E EER R+  EKM E++EK+ E ++ Q +     +      ++ R R     E E
Sbjct: 403 DERLREKEERMREQ-EKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIR-----ERE 456

Query: 210 RDRREESRRHGRNWGGPDFERVRCGLEHERQGRRAGLGSAGDMTLSMTGRERSEYLRWKQ 269
           +  REE             +      + E++ ++  L    +        +  E   W+Q
Sbjct: 457 KKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQ 516

Query: 270 EREKIDQERLQRHRKPTGQWRREWDAEKTDGMFKDGPVPAHEPSHRYDDQAWARPPKPPT 329
           E +  DQE +    K    WR+E   E+ D M++       +    +D +          
Sbjct: 517 EEKIRDQEEMWGQEKK--MWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQ 574

Query: 330 FGEFLSQH---KAEASSRRRRKSSRPQAKAA-----------PRAYSDHDDRWETKEGAA 375
             +   Q    + E   R R K  R + +              +     +  WE +E   
Sbjct: 575 EKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQ 634

Query: 376 SPAPETPQPTSPETSPKETPMQPPEIPAPAHRPPE----DEGEENEGEEDEEWEDISEDE 431
               +  +        +E   +   +P    +  E     E E+ + +E++ WE    ++
Sbjct: 635 EQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEK 694

Query: 432 EEEEIEVEEGDEEEPAQDHQAPE 454
           + +E E +  D+E+  ++    E
Sbjct: 695 KTQEQEKKTWDQEKMREEESMRE 717



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 100/465 (21%), Positives = 176/465 (37%), Gaps = 48/465 (10%)

Query: 10  KEEKDAELDKRIEALRRKNEALIRRYQEIEEDRKKAELEGVAVTAPRKGRSVEKENVAVE 69
           KEEK A    + EALRR+ EA     + +    +K ELE     +    R  E  N+   
Sbjct: 80  KEEKKASHQHQ-EALRREIEAQDHTIRILT--CQKTELETALYYSQDAARKFEDGNLGTP 136

Query: 70  SEKNLGPSRRSPGTPRPPGASKGGRTPPQQGGRAGMGRASRSWEGSPGEQPRGGGAGGRG 129
           S  NL  S+   G+P   G       P +    A  GR   SW  + GE  R   A    
Sbjct: 137 SSFNLALSQAFRGSPL--GCVSTSLIPGESKDLA--GRLHHSWHFA-GELQRALSAVSTR 191

Query: 130 RRGRGRGSPHLSGAGDTSISD--RKSKEWEERRRQNIEKMNE----EMEK------IAEY 177
            +   R    L+   D    +  R +   EE +++N E   +    E EK      + E 
Sbjct: 192 HKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKEL 251

Query: 178 ERN-QREGVLEPNPVRNFLDDPR-RRSGPLEESERDRREESRRHGRNWGGPDFERVRCGL 235
           +R  +R   L P    N L +   R+   L E E+  R++  +  R       +  +   
Sbjct: 252 KRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMRE 311

Query: 236 EHERQGRRAGLGSAGDMTLSMTGRE-------RSEYLRWKQEREKIDQERLQRHRKPTGQ 288
           + E+  R+       +  L    +E       R +  + +++ EK+ ++  +   +    
Sbjct: 312 QEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKM 371

Query: 289 WRRE---WDAEK----TDGMFKDGPVPAHEPSHRYDDQAWARPPKPPTFGEFLSQHKAEA 341
           WR+E   W+ EK     +   +D      E   R  ++   R  +     E + + + E 
Sbjct: 372 WRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKE-ERMREQEKMWEQVEKMREEK 430

Query: 342 SSRRRRKSSRPQAKAAPRAYSDHDDRWETKEGAASPAPETPQPTSPETSPKETPM-QPPE 400
             + + K +R Q +         ++R   +E       ET +    +   +E  M +  E
Sbjct: 431 KMQEQEKKTRDQEEK-----MQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEE 485

Query: 401 IPAPAHRPPED-----EGEENEGEEDEEWEDISEDEEEEEIEVEE 440
                 R PE      E E+ + +E++ WE   +  ++EE+  +E
Sbjct: 486 KEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQE 530



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 60/315 (19%), Positives = 113/315 (35%), Gaps = 43/315 (13%)

Query: 145 DTSISDRKSKEW--EERRRQNIEKMNEEMEKIAEYERNQREGVLEPNPVRNFLDDPRRRS 202
           +  I  ++ K W  EER R+   KM E+ EK+   E+  RE   E       L    R  
Sbjct: 285 EKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKEL----REQ 340

Query: 203 GPLEESERDRREESRRHGRNWGGPDFERVRCGLEHERQGRRAGLGSAGDMTLSMTGRERS 262
             L E E   +E+  +          +  +   + ER   +               RE+ 
Sbjct: 341 KELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQ-----------EKQMREQE 389

Query: 263 EYLRWKQEREKIDQERLQRHRKPTGQWRREWDAEKTDGMFKDGPVPAHEPSHRYDDQAWA 322
           + +R ++ER     ERL+   +   +  + W  E+ + M ++  +   E   R  ++   
Sbjct: 390 QKMRDQEERMWEQDERLREKEERMREQEKMW--EQVEKMREEKKMQEQEKKTRDQEE--- 444

Query: 323 RPPKPPTFGEFLSQHKAEASSRRRRKSSRPQAKAAPRAYSDHDDRWETKEGAASPAPETP 382
                    +   + +     ++ R+      +   +     ++ WE +E       E  
Sbjct: 445 ---------KMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEE------KEWQ 489

Query: 383 QPTSPETSPK---ETPMQPPEIPAPAHRPPEDEGEENEGEEDEEWEDISEDEEEEEI--- 436
           Q   PE   K   +  MQ  E           + EE  G+E + W      E+E+++   
Sbjct: 490 QQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQ 549

Query: 437 EVEEGDEEEPAQDHQ 451
           E +  D+E+   D +
Sbjct: 550 EEKMRDQEQKMWDQE 564



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 35/150 (23%), Positives = 61/150 (40%), Gaps = 15/150 (10%)

Query: 148 ISDRKSKEWEERRRQNIEKMNEEMEKIAEYERNQREGVLEPNPVRNFLDDPRRRSGPLEE 207
           + ++K K WE  + Q  EKM E+ EKI E E+ +++   +    + +  +  R    + E
Sbjct: 660 LPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKK--TQEQEKKTWDQEKMREEESMRE 717

Query: 208 SERDRREESRRHGRNWGGPDFERVRCGLEHERQGRRAGLGSAGDMTLSMTGRERSEYLRW 267
            E+  REE             E +R   E  ++          +M          E   W
Sbjct: 718 REKKMREEE------------EMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMW 765

Query: 268 KQEREKIDQERLQRHRKPTGQWRREWDAEK 297
           +Q+R    +E+L  H K   Q  + W+ E+
Sbjct: 766 EQQRLPEQKEKLWEHEKMQEQ-EKIWEQEE 794



 Score = 39.7 bits (91), Expect = 0.007
 Identities = 67/332 (20%), Positives = 121/332 (36%), Gaps = 34/332 (10%)

Query: 150 DRKSKEWEERRRQNIEKMNEEMEKIAEYERNQREGVLEPNPVRNFLDDPRRRSGPLEESE 209
           ++K +E E++ R   EKM EE E+I E E+  RE           +          EE E
Sbjct: 429 EKKMQEQEKKTRDQEEKMQEE-ERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKE 487

Query: 210 RDRREESRRHGRNWGGPDFERVRCGL---EHERQGRRAGLGSAGDMTLSMTGRERSEYLR 266
             ++    +  + W     +     +   E + + +    G    M      RE+ + + 
Sbjct: 488 WQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQM- 546

Query: 267 WKQEREKIDQERL------QRHRKPTGQWRREWDAEKTDGMFKDGPVPAHEPSHRYDDQA 320
           W+QE +  DQE+       +  +K   Q ++ WD E+   M ++  +   E   R +++ 
Sbjct: 547 WEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEK--MREEERMREREKKMREEEEM 604

Query: 321 WARPPKPPTFGEFLSQHKAEASSRRRRKSSRPQAKA---APRAYSDHDDRWETK------ 371
                +     E   Q + E    +  K    + K      + +   +  WE +      
Sbjct: 605 MREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQK 664

Query: 372 ----EGAASPAPETPQPTSP-----ETSPKETPMQPPEIPAPAHRPPEDEGEENEGEEDE 422
               E       E  Q         E   K+T  Q  +         E+   E E +  E
Sbjct: 665 EKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMRE 724

Query: 423 EWEDISEDEE---EEEIEVEEGDEEEPAQDHQ 451
           E E + E EE   E+E +++E +EE   Q+ +
Sbjct: 725 EEEMMREQEEKMQEQEEKMQEQEEEMWEQEEK 756



 Score = 39.7 bits (91), Expect = 0.007
 Identities = 54/315 (17%), Positives = 123/315 (39%), Gaps = 37/315 (11%)

Query: 148 ISDRKSKEWE-ERRRQNIEKMNEEMEKIAEYER--NQREGVLEPNPVRNFLDDPRRRSGP 204
           + ++K K WE E+ ++  EK+ E+ EKI + E    Q + +     +R   D    +   
Sbjct: 493 LPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEK 552

Query: 205 LEESER---DRREESRRHGRNWGGPDFERVRCGLEHERQGRRAGLGSAGDMTLSMTGRER 261
           + + E+   D+ E   +  +      +++     E ER   R               RE 
Sbjct: 553 MRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMRER-----------EKKMREE 601

Query: 262 SEYLRWKQEREKIDQERLQRHRKPTGQWRREWDAEKTDGMFKDGPVPAHEPSHRYDDQAW 321
            E +R ++E+ +  +E++Q       Q  + W+ E+     ++      E     +++ W
Sbjct: 602 EEMMREQEEKMQEQEEKMQE------QEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMW 655

Query: 322 ARPPKPPTFGEFLSQHKAEASSRRRRKSSR--PQAKAAPRAYSDHDDRWETKEGAASPAP 379
            +   P    +     K +   + + +  +   Q K   +        W+ ++       
Sbjct: 656 EQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREE--- 712

Query: 380 ETPQPTSPETSPKETPMQPPEIPAPAHRPPEDEGEENEGEEDEEWEDISEDEEEEEIEVE 439
           E+ +    +   +E  M+  E         +++ E+ + +E+E WE   +  E+EE   E
Sbjct: 713 ESMREREKKMREEEEMMREQE------EKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWE 766

Query: 440 E---GDEEEPAQDHQ 451
           +    +++E   +H+
Sbjct: 767 QQRLPEQKEKLWEHE 781



 Score = 33.1 bits (74), Expect = 0.65
 Identities = 33/140 (23%), Positives = 58/140 (41%), Gaps = 31/140 (22%)

Query: 148 ISDRKSKEWEERRRQNIEKMNEEMEKIAEYERNQREGVLEPNPVRNFLDDPRRRSGPLEE 207
           + ++K K WE  + Q  EK+ E+ EK+ + E   R                       EE
Sbjct: 770 LPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMR---------------------GQEE 808

Query: 208 SERDRREESR-RHGRNWGGPDFERVRCGLEHERQGRRAGL-GSAGDMTLSMTG-----RE 260
             R + E+ R +  + WG    E    G E +  G+   + G    M   M G     RE
Sbjct: 809 KMRGQEEKMRGQEEKMWGQ---EEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMRE 865

Query: 261 RSEYLRWKQEREKIDQERLQ 280
           + E +R ++E+ +  +E+++
Sbjct: 866 QEEKMRGQEEKMREQEEKMR 885


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 52.8 bits (125), Expect = 8e-07
 Identities = 73/312 (23%), Positives = 121/312 (38%), Gaps = 31/312 (9%)

Query: 150 DRKSKEWEERRRQNIEKMNEEME----KIAEYERNQREGVLEPNPVRNFLDDPRRRSGPL 205
           D+  K  EERR+Q +++  EE      K  E ER ++E   E    R   ++ RR+    
Sbjct: 576 DQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLK 635

Query: 206 EESERDRR-------EESRRHGRNWGGPDFERVRCGLEHERQGRRAGLGSAGDMTLSMTG 258
            E + +RR       ++ RR  R     + ER+   L+ E +  R     A +       
Sbjct: 636 SEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARE 695

Query: 259 RERSEYLRWKQEREKIDQER----LQRHRKPTGQWRREWDAEKTDGMFKDGPVPAHEPSH 314
           R +S   +W+ + E     R      R RK  GQ RR+   EK      +      E +H
Sbjct: 696 RIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAH 755

Query: 315 RYDDQAWARPPKPPTFGEFLSQHKAEASSR--RRRKSSRPQAKAAPRAYSDHDDRWETKE 372
           R   +   R        +F  Q +AE  S   R+R S+RP  +         ++R + +E
Sbjct: 756 RQQQEEEQR-------RDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEER-QQRE 807

Query: 373 GAASPAPETPQPTSPETSPKETPMQPPEIPAPAHRPPEDEGEENEGEEDEEWEDISEDEE 432
               P  E  +    +   +E  +Q  E      R       E   +  EE + + ED+E
Sbjct: 808 QRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQR------RERAQQLQEEEDGLQEDQE 861

Query: 433 EEEIEVEEGDEE 444
               + +  D++
Sbjct: 862 RRRSQEQRRDQK 873



 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 63/335 (18%), Positives = 127/335 (37%), Gaps = 47/335 (14%)

Query: 152 KSKEWEERRRQNIEKMNEEM-------EKIAEYERNQREGVLEPNPVRNFLDDPRRRSGP 204
           + K  +ERR Q +++  EE        E+   +E+ +R+  L+ +       +  RR   
Sbjct: 435 EQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRD------QEEERRERW 488

Query: 205 LEESERDRREESRRHGRNWGGPDFERVRCGLEHERQGRRAGLGSAGDMTLSMTGRERSEY 264
           L+  E +RRE+  R  +       ER    L+ + +  R       +  L     ER E 
Sbjct: 489 LKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQ 548

Query: 265 LRWKQEREKIDQERLQRHRKPTGQWRREW----------------DAEKTDGMFKDGPVP 308
           L  ++E ++++QER ++  K   + RR+                   E+ +   K   V 
Sbjct: 549 LLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVE 608

Query: 309 AHEPSHRYDDQAWARPPKPPTFGEFLSQHKAEASSRRRRKSSRPQAKAAPRAYSDHDDRW 368
             E   R + +     P+     + L   + E   +++ +  + + +       + ++R 
Sbjct: 609 RLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERL 668

Query: 369 ETK-------EGAASPAPETPQPTSPETSPKETPMQPPEIPAPA--------HRPPEDEG 413
           E +       E       E  Q  + E      P    ++ + A         RP + EG
Sbjct: 669 EQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEG 728

Query: 414 EENEGEEDEE---WEDISEDEEEEEIEVEEGDEEE 445
           +    E++E+    E   + +EEE    ++ +EE+
Sbjct: 729 QRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQ 763



 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 67/307 (21%), Positives = 120/307 (39%), Gaps = 40/307 (13%)

Query: 151 RKSKEWEERRRQNIEKMNEEMEKIAEYERNQR-EGVLEPNPVRNFLDDPRRRSGPLEESE 209
           R  +E EERR Q +++  E  ++  + E+ +R E  L+   V     + RR     +  +
Sbjct: 566 RLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERRE----QRLK 621

Query: 210 RDRREESRRHGRNWGGPDFERVRCGLEHERQGRRAGLGSAGDMTLSMTGRERSEYLRWKQ 269
           R+  EE RR          ER +  L  E+Q RR       +    +  R + E+   ++
Sbjct: 622 REEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERR 681

Query: 270 EREKIDQERLQ-----RHRKPTGQWRREWDAEKTDGMFKDGPVPAHEPSHRYDDQAWARP 324
           E+E  ++E+ Q     + R P  QW+ E +A+                      + ++RP
Sbjct: 682 EQELAEEEQEQARERIKSRIPKWQWQLESEADARQS------------------KVYSRP 723

Query: 325 PKPPTFGEFLSQHKAEASSRRRRKSSRPQAKAAPRAYSDHDDRWETKEGAASPAPETPQP 384
            K         + + E   +RRR+ S  Q +   RA+    +  + ++       E    
Sbjct: 724 RKQEG-----QRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKS- 777

Query: 385 TSPETSPKETPMQPPEIPAPAHRPPEDEGEENEGE---EDEEWEDISEDEEEEEIEVEEG 441
              E   +    +PP       +   +E ++ E     E+EE E       E E E++  
Sbjct: 778 ---ERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFL 834

Query: 442 DEEEPAQ 448
           +EEE  Q
Sbjct: 835 EEEEQLQ 841



 Score = 49.7 bits (117), Expect = 7e-06
 Identities = 98/453 (21%), Positives = 172/453 (37%), Gaps = 31/453 (6%)

Query: 10   KEEKDAELDKRIEALRRKNEALIRRYQEIEEDRKKAELEGVAVTAPRKGRSVEKENVAVE 69
            +EE++  L++R   L+R++E   RR QE+ E+ ++   E +    P+    +E E  A +
Sbjct: 661  REEEEERLEQR---LKREHEEE-RREQELAEEEQEQARERIKSRIPKWQWQLESEADARQ 716

Query: 70   SEKNLGPSRRSPGTPRPPGASKGGRTPPQQGGRAGMGRASRSWEGSPGEQPRGGGAGGRG 129
            S+    P R+  G  R     +  R    +       RA R  +    EQ R      + 
Sbjct: 717  SKVYSRP-RKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEE--EQRRDFTWQWQA 773

Query: 130  RRGRGRGSPHLSGAGDTSISDRKSKEWEERRRQNIEKMNEEMEKIAEYERNQREGVLEPN 189
                 RG   LS          +    EER+++    + EE EK  E  R QR    E  
Sbjct: 774  EEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEK--EQRRRQRR---ERE 828

Query: 190  PVRNFLDDP-----RRRSGPLEESERDRREESRRHGRNWGGPDFERVRCGLEHERQGRRA 244
                FL++      R R+  L+E E   +E+  R        D ++ R  LE ER+ RR 
Sbjct: 829  KELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRD-QKWRWQLEEERKRRRH 887

Query: 245  GLGSAGDMTLSMTGRERSEYLRWKQEREKIDQERLQRHRKPTGQWRREWDAEKTDGMF-- 302
             L +   +   +  R+  + L+ ++E  + ++   +R ++   Q+R E   ++ +     
Sbjct: 888  TLYAKPALQEQL--RKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLR 945

Query: 303  -KDGPVPAHEPSHRYDDQAWARPPKPPTFGEFLSQHKAEASSRRRRKSSRPQAKAAPRAY 361
             +       E   +Y      +  +    GE   + + +   ++ R+    Q +      
Sbjct: 946  EEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLR 1005

Query: 362  SDHDDR----WETKEGAASPAPETPQPTSPETSPK----ETPMQPPEIPAPAHRPPEDEG 413
             + + R    WE +        +  +    E   K    E   Q  E         +  G
Sbjct: 1006 EEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLG 1065

Query: 414  EENEGEEDEEWEDISEDEEEEEIEVEEGDEEEP 446
            EE E    +E E     EEE + E E+   EEP
Sbjct: 1066 EERETRRRQELERQYRKEEELQQEEEQLLREEP 1098



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 71/310 (22%), Positives = 116/310 (37%), Gaps = 24/310 (7%)

Query: 154 KEWEERRRQNIEKMNEEMEKIAEYERNQREGVLEPNPVRNFLDDPRRRSGPLEESERDRR 213
           +E + RR Q + +  EE     ++E+ +RE  L+        +   RR     E E +R 
Sbjct: 415 REQQLRREQQLRREQEEERHEQKHEQERREQRLKR-------EQEERRDWLKREEETERH 467

Query: 214 EESRRHGRNWGGPDFERVRCGLEHERQGRRAGLGSAGDMTLSMTGRERSEYLRWKQEREK 273
           E+ RR  +     + ER    L+ E + RR       +  L     ER E    +QE E 
Sbjct: 468 EQERRKQQLKRDQEEERRERWLKLEEEERREQQ-ERREQQLRREQEERREQRLKRQEEE- 525

Query: 274 IDQERLQRHRKPTGQWRREWDAEKTDGMFKDGPVPAHEPSHRYDDQAWARPPKPPTFGEF 333
              ERLQ+  +   Q RRE + E+ + + K       E   R       +  +     + 
Sbjct: 526 ---ERLQQRLRSEQQLRREQE-ERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKR 581

Query: 334 LSQHKAEASSRRRRKSSRPQAKAAPRAYSDHDDRWETKEGAASPAPETPQPTSPETSPKE 393
             + + +   R + +    + K       + ++R E +     P  E  Q        +E
Sbjct: 582 EEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEE 641

Query: 394 TPMQPPEIPAPAHRPPEDEGEEN--EGEEDEEWEDISEDEEEEEIEVEEGDEEEPAQDHQ 451
              Q         R  ++  E+     EE+E  E   + E EEE   +E  EEE     Q
Sbjct: 642 RRQQQ------LRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEE---QEQ 692

Query: 452 APEAAPTGIP 461
           A E   + IP
Sbjct: 693 ARERIKSRIP 702



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 109/535 (20%), Positives = 203/535 (37%), Gaps = 97/535 (18%)

Query: 5    LDLKSKEEKDAELDK----RIEALRRKNEALIRRYQEIEEDRKKAELEGVAVTAPRKGRS 60
            L+ + +EE++ + ++    R E  +R+ + L R+Y+E EE +++ E     +   ++ R 
Sbjct: 1136 LERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQ---LLREEQEKRR 1192

Query: 61   VEKENVAVESEKNLGPSRRSPGTPRPPGASKGGRTPPQQGGRAGMGRASRSWEGSPGEQP 120
             E+E    E E+     R+         +    +  P++       +     +G   EQ 
Sbjct: 1193 QERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVY--CKGRENEQF 1250

Query: 121  RGGGAGGRGRRGRGRGSPHLSGAGDTSISDRKSKEWEERRRQNIEKMNEEMEKIAEYERN 180
            R         R   +   HL G       +++ + W++R R   E+   E E+  E +R 
Sbjct: 1251 RQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRR 1310

Query: 181  QREGVLEPNPVRNFLDDPRRR------------------SGPLEESERDR--REESRRH- 219
             R+   E   +R   ++ RRR                    PL   ERDR  REE  RH 
Sbjct: 1311 DRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQ 1370

Query: 220  --GRNWGGPD-----FERVRCGLEHERQGR-----------RAGLGSAGDMTLSMTGRER 261
              GR +   +      ER R  L+ E+Q R           R       +  LS   R+R
Sbjct: 1371 EQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDR 1430

Query: 262  ------SEYLRWKQEREKIDQE---RLQRHRKPTGQ------------WRREWD------ 294
                   +  R ++ER+ +++E   R +RHRK   +             R+E D      
Sbjct: 1431 KFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEE 1490

Query: 295  -----AEKTDGMFKDGPVPAHEPSHRY--DDQAWARPPKPPTFGEFLSQHKAEASSRRRR 347
                  ++ D  F++  + + EP  ++  ++Q   R  +   F +       E    RR+
Sbjct: 1491 EQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQ-------EEQQLRRQ 1543

Query: 348  KSSRPQAKAAPRAYSDHDDRWETKEGAASPAPETPQPTSPETSPKETPMQPPEIPAPAHR 407
            +  + + +   R + + +   + +E       E  +    E        Q  +      +
Sbjct: 1544 ERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQ 1603

Query: 408  PPEDEGEENEGEEDE----EWEDISEDEEEEEIEVEEGD----EEEPAQDHQAPE 454
                EG++   +E +    E E + ++ EE+++  +E D    EEEP    Q  E
Sbjct: 1604 LRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQERE 1658



 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 100/485 (20%), Positives = 177/485 (36%), Gaps = 63/485 (12%)

Query: 7    LKSKEEKDAELDKRIEALRRKNE----ALIRRYQEIEEDRKKAELEGVAVTAPRKGRSVE 62
            LK +EEK  E ++R + L+R+ E     L++R +E  + R K E E       ++ +  E
Sbjct: 550  LKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQE---ERLEQRLKREE 606

Query: 63   KENVAVESEKNLGPSRRSPGTPRPPGASKGGRTPPQQGGRAGMGRASRSWEGSPGEQPRG 122
             E +  E  +     R  P   R     K      ++  +    +  R  +    E+   
Sbjct: 607  VERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEE-- 664

Query: 123  GGAGGRGRRGRGRGSPHLSGAGDTSISDRKSKEWEERRRQNIEKMNEEMEKIAEYERNQ- 181
                   R  +     H     +  +++ + ++  ER +  I K   ++E  A+  +++ 
Sbjct: 665  -----EERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKV 719

Query: 182  --REGVLEPNPVRNFLDDPRRRS------GPLEESERDRREESRRHGRNWGGPDFERVRC 233
              R    E    R   ++ RRR          E + R ++EE +R    W     E+   
Sbjct: 720  YSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSER 779

Query: 234  GLEHERQGRRAGLGSAGDMTLSMTGRERSEYLRWKQEREKIDQERLQRHRKPTGQWRREW 293
            G   +R   R  L    +  L    R++ E     +E EK  + R +R R+   Q+  E 
Sbjct: 780  G--RQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEE 837

Query: 294  D-----------AEKTDGMFKDGPVPAHEPSHRYDDQAW----------------ARPPK 326
            +            E+ DG+ +D      +   R  DQ W                A+P  
Sbjct: 838  EQLQRRERAQQLQEEEDGLQEDQERRRSQEQRR--DQKWRWQLEEERKRRRHTLYAKPAL 895

Query: 327  PPTF--GEFLSQHKAEASSRRRRKSSRPQAKAAPRAYSDHDDRWETKEGAASPAPETPQP 384
                   + L Q + E   R  R+  R Q +   R Y + +   + +E       E  + 
Sbjct: 896  QEQLRKEQQLLQEEEEELQREEREKRRRQEQ--ERQYREEEQLQQEEEQLLREEREKRRR 953

Query: 385  TSPETS-PKETPMQPPEIPAPAHRPPEDEGEENEGEEDEEWEDISEDEEE---EEIEVEE 440
               E    K+  +Q  E       P +   +E E +  EE E++ ++EE+   EE E   
Sbjct: 954  QERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREE-EELQQEEEQLLREEREKRR 1012

Query: 441  GDEEE 445
              E E
Sbjct: 1013 RQEWE 1017



 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 59/297 (19%), Positives = 115/297 (38%), Gaps = 22/297 (7%)

Query: 151 RKSKEWEERRRQNIEKMNEEMEKIAEYERNQREGVLEPNPVRNFLDDPRRRSGPLEESER 210
           R+ ++ EE+++Q + +  +   K  E  R Q+E   E    R       RR   L   + 
Sbjct: 287 RRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERRE--QQEERREQQLRREQE 344

Query: 211 DRREESRRHGRNWGGPDFERVRCGLEHERQGRRAGLGSAGDMTLSMTGRERSEYLRWKQE 270
           +RRE+  R  +     + ER    L  E++  R       +  L      R + LR +Q+
Sbjct: 345 ERREQQLRREQ-----EEERREQQLRREQEEERREQQLRREQQL-----RREQQLRREQQ 394

Query: 271 REKIDQERLQRHRKPTGQWRREWDAEKTDGMFKDGPVPAHEPSHRYDDQAWARPPKPPTF 330
             +  Q R ++  +   Q RRE    +   + ++     HE  H  + +      +    
Sbjct: 395 LRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEER 454

Query: 331 GEFLS-QHKAEASSRRRRKSSRPQAKAAPRAYSDHDDRW---ETKEGAASPAPETPQPTS 386
            ++L  + + E   + RRK    + +   R      +RW   E +E          Q   
Sbjct: 455 RDWLKREEETERHEQERRKQQLKRDQEEERR-----ERWLKLEEEERREQQERREQQLRR 509

Query: 387 PETSPKETPMQPPEIPAPAHRPPEDEGEENEGEEDEEWEDISEDEEEEEIEVEEGDE 443
            +   +E  ++  E      +    E ++   E++E  E + + EEE+ +E E  ++
Sbjct: 510 EQEERREQRLKRQEEEERLQQRLRSE-QQLRREQEERREQLLKREEEKRLEQERREQ 565



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 61/300 (20%), Positives = 108/300 (36%), Gaps = 25/300 (8%)

Query: 152 KSKEWEERRRQNIEKMNEEMEKIAEYERNQREGVLEPNPVRNFLDDPRRRSGPLEESE-- 209
           + K  EE+++Q  E+ +   ++  E E  +RE VL     +   ++P+R+    EE E  
Sbjct: 219 RRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQL 278

Query: 210 ---------RDRREESRRHGRNWGGPDFERVRCGLEHERQGRRAGLGSAGDMTLSMTGRE 260
                    R+R+EE ++  R        R +   E ER+ ++       +       R 
Sbjct: 279 RKLERQELRRERQEEEQQQQRLRREQQLRRKQ---EEERREQQEERREQQERREQQEERR 335

Query: 261 RSEYLRWKQEREKIDQERLQRHRKPTGQWRREWDAEKTDGMFKDGPVPAHEPSHRYDDQA 320
             +  R ++ER +    R Q   +   Q RRE + E+ +   +       E   R + Q 
Sbjct: 336 EQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQL 395

Query: 321 WARPPKPPTFGEFLSQHKAEASSRRRRKSSRPQAKAAPRAYSDHDDRWETKEGAASPAPE 380
                          Q + E   RR ++  R Q     +    H+ + E +        E
Sbjct: 396 RREQQLRRE-----QQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKRE 450

Query: 381 TPQPTSPETSPKETPMQPPEIPAPAHRPPEDEGEENEGEEDEEWEDISEDEEEEEIEVEE 440
             +        +ET     E      R  +    + E E  E W  + E+E  E+ E  E
Sbjct: 451 QEERRDWLKREEETERHEQE------RRKQQLKRDQEEERRERWLKLEEEERREQQERRE 504



 Score = 39.3 bits (90), Expect = 0.009
 Identities = 72/315 (22%), Positives = 122/315 (38%), Gaps = 43/315 (13%)

Query: 150  DRKSKEWEERRRQNIEKMNEEMEKIAEYERNQREGVLEPNPVRNFLDDP---RRRSGPLE 206
            DRK +E E+ R++  E+     E+  ++ R + + V      R F++D    RR+ G  +
Sbjct: 1554 DRKFREEEQLRQEREEQQLSRQERDRKF-RLEEQKVRRQEQERKFMEDEQQLRRQEGQQQ 1612

Query: 207  -ESERDR-----------REESRRHGRNWGGPDFERVRCGLEHERQGRRAGLGSAGDMTL 254
               ERDR           REE + H +       ER R  LE E Q RR           
Sbjct: 1613 LRQERDRKFREDEQLLQEREEQQLHRQ-------ERDRKFLEEEPQLRRQEREQQLRHDR 1665

Query: 255  SMTGRERSEYLRWKQEREKIDQERLQRHRKPTGQWRREWDAEKTDGMFKDGPVPAHEPSH 314
                RE  + L+  +E++   QER ++ R+   Q RR+    K   + ++  +   E   
Sbjct: 1666 DRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKF--LQEEQQLRRQELER 1723

Query: 315  RYDDQAWARPPKPPTFGEFLSQHKAEASSRRRR----KSSRPQAKAAPRAYSDHDDRWET 370
            ++ ++   R        +   Q +     R R+    +  RP+ +       + D ++  
Sbjct: 1724 KFREEEQLR--------QETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFRE 1775

Query: 371  KEGAASPAPETPQPTSPETSPK--ETPMQPPEIPAPAHRPPEDEGE---ENEGEEDEEWE 425
            +E       E  Q  S E+  K  E      E      RP + +G+   E E  + EE E
Sbjct: 1776 EEQLRQER-EEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQE 1834

Query: 426  DISEDEEEEEIEVEE 440
                 E + +   EE
Sbjct: 1835 QRLRQERDRQYRAEE 1849



 Score = 31.2 bits (69), Expect = 2.5
 Identities = 32/138 (23%), Positives = 57/138 (41%), Gaps = 15/138 (10%)

Query: 151  RKSKEWEERRRQNIEKMNEEMEKIAEYERNQREGVLEPNPVRNFLDDPRRRSGPLEESER 210
            R  +E ++ RRQ  ++   E E++ +    Q+    E +  R F ++ + R    E  E+
Sbjct: 1756 RPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESD--RKFREEEQLRQ---EREEQ 1810

Query: 211  DRREESRRHGRNWGGPDFE----RVRCGLEHERQGRRAGLGSAGDMTLSMTGRERSEYLR 266
              R + R     W     +      R   E +RQ R      A +   +     R E   
Sbjct: 1811 QLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYR------AEEQFATQEKSRREEQEL 1864

Query: 267  WKQEREKIDQERLQRHRK 284
            W++E +K  QER ++ R+
Sbjct: 1865 WQEEEQKRRQERERKLRE 1882


>gi|62244004 modulator of estrogen induced transcription isoform b
           [Homo sapiens]
          Length = 1016

 Score = 52.8 bits (125), Expect = 8e-07
 Identities = 72/319 (22%), Positives = 120/319 (37%), Gaps = 77/319 (24%)

Query: 147 SISDRKSKEWEERRRQNIEKMNEEM--EKIAEYERNQREGVLEPNPVRNFLDDPRRRSGP 204
           S+  ++ K++  +     EKM E+   E +  +ER           +R  ++  RRR   
Sbjct: 572 SLDKKRDKDYRRKEILPFEKMKEQRLREHLVRFER-----------LRRAMELRRRR--- 617

Query: 205 LEESERDRREESRRHGRNWGGPDFERVRCGLEHERQGRRAGLGSAGDMTLSMTGRERSEY 264
            E +ER+RRE              ER+R   E E + R                RER E 
Sbjct: 618 -EIAERERRER-------------ERIRIIREREERERL------------QRERERLEI 651

Query: 265 LRWKQEREKIDQERLQRHRKPTGQWRRE--------------------WDAEKTDGMFKD 304
            R K ERE++++ERL+R R    Q RR+                    ++ EK + + + 
Sbjct: 652 ERQKLERERMERERLERERIRIEQERRKEAERIAREREELRRQQQQLRYEQEKRNSLKRP 711

Query: 305 GPVPAHEPSHRYDDQAWARPPKPPTFGEFLSQHKAEASSRR--------RRKSSRPQAKA 356
             V      HR DD  W+   K     +    H ++ S ++        R +   P++ A
Sbjct: 712 RDV-----DHRRDDPYWSENKKLSLDTDARFGHGSDYSRQQNRFNDFDHRERGRFPESSA 766

Query: 357 APRAYSDHDDRW--ETKEGAASPAPETPQPTSPETSPKETPMQPPEIPAPAHRPPEDEGE 414
              +  +  DR+  +++   A P      P+        +  +  E P P +   E +  
Sbjct: 767 VQSSSFERRDRFVGQSEGKKARPTARREDPSFERYPKNFSDSRRNEPPPPRNELRESDRR 826

Query: 415 ENEGEEDEEWEDISEDEEE 433
           E  GE DE    I  D  +
Sbjct: 827 EVRGERDERRTVIIHDRPD 845



 Score = 31.2 bits (69), Expect = 2.5
 Identities = 19/56 (33%), Positives = 31/56 (55%), Gaps = 2/56 (3%)

Query: 405 AHRPPEDEGEENEGEEDEEWEDISEDEEEEE--IEVEEGDEEEPAQDHQAPEAAPT 458
           AH   E EG E+  +ED E ++I   E E++  +  ++G+EEE  ++    EA  T
Sbjct: 151 AHELIEAEGIEDIEKEDIESQEIEAQEGEDDTFLTAQDGEEEENEKEGSLAEADHT 206



 Score = 30.0 bits (66), Expect = 5.5
 Identities = 24/68 (35%), Positives = 37/68 (54%), Gaps = 6/68 (8%)

Query: 8   KSKEEKDAELDKRIEALRRKNEALIRRYQEIEEDRKKAELEGVAVTAPRKGRSV---EKE 64
           K KE++  E   R E LRR  E  +RR +EI E R++ E E + +   R+ R     E+E
Sbjct: 591 KMKEQRLREHLVRFERLRRAME--LRRRREIAE-RERRERERIRIIREREERERLQRERE 647

Query: 65  NVAVESEK 72
            + +E +K
Sbjct: 648 RLEIERQK 655


>gi|63176611 modulator of estrogen induced transcription isoform a
           [Homo sapiens]
          Length = 1034

 Score = 52.8 bits (125), Expect = 8e-07
 Identities = 72/319 (22%), Positives = 120/319 (37%), Gaps = 77/319 (24%)

Query: 147 SISDRKSKEWEERRRQNIEKMNEEM--EKIAEYERNQREGVLEPNPVRNFLDDPRRRSGP 204
           S+  ++ K++  +     EKM E+   E +  +ER           +R  ++  RRR   
Sbjct: 590 SLDKKRDKDYRRKEILPFEKMKEQRLREHLVRFER-----------LRRAMELRRRR--- 635

Query: 205 LEESERDRREESRRHGRNWGGPDFERVRCGLEHERQGRRAGLGSAGDMTLSMTGRERSEY 264
            E +ER+RRE              ER+R   E E + R                RER E 
Sbjct: 636 -EIAERERRER-------------ERIRIIREREERERL------------QRERERLEI 669

Query: 265 LRWKQEREKIDQERLQRHRKPTGQWRRE--------------------WDAEKTDGMFKD 304
            R K ERE++++ERL+R R    Q RR+                    ++ EK + + + 
Sbjct: 670 ERQKLERERMERERLERERIRIEQERRKEAERIAREREELRRQQQQLRYEQEKRNSLKRP 729

Query: 305 GPVPAHEPSHRYDDQAWARPPKPPTFGEFLSQHKAEASSRR--------RRKSSRPQAKA 356
             V      HR DD  W+   K     +    H ++ S ++        R +   P++ A
Sbjct: 730 RDV-----DHRRDDPYWSENKKLSLDTDARFGHGSDYSRQQNRFNDFDHRERGRFPESSA 784

Query: 357 APRAYSDHDDRW--ETKEGAASPAPETPQPTSPETSPKETPMQPPEIPAPAHRPPEDEGE 414
              +  +  DR+  +++   A P      P+        +  +  E P P +   E +  
Sbjct: 785 VQSSSFERRDRFVGQSEGKKARPTARREDPSFERYPKNFSDSRRNEPPPPRNELRESDRR 844

Query: 415 ENEGEEDEEWEDISEDEEE 433
           E  GE DE    I  D  +
Sbjct: 845 EVRGERDERRTVIIHDRPD 863



 Score = 30.4 bits (67), Expect = 4.2
 Identities = 17/47 (36%), Positives = 28/47 (59%), Gaps = 2/47 (4%)

Query: 405 AHRPPEDEGEENEGEEDEEWEDISEDEEEEE--IEVEEGDEEEPAQD 449
           AH   E EG E+  +ED E ++I   E E++  +  ++G+EEE  +D
Sbjct: 151 AHELIEAEGIEDIEKEDIESQEIEAQEGEDDTFLTAQDGEEEENEKD 197



 Score = 30.0 bits (66), Expect = 5.5
 Identities = 24/68 (35%), Positives = 37/68 (54%), Gaps = 6/68 (8%)

Query: 8   KSKEEKDAELDKRIEALRRKNEALIRRYQEIEEDRKKAELEGVAVTAPRKGRSV---EKE 64
           K KE++  E   R E LRR  E  +RR +EI E R++ E E + +   R+ R     E+E
Sbjct: 609 KMKEQRLREHLVRFERLRRAME--LRRRREIAE-RERRERERIRIIREREERERLQRERE 665

Query: 65  NVAVESEK 72
            + +E +K
Sbjct: 666 RLEIERQK 673


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.307    0.129    0.386 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,745,961
Number of Sequences: 37866
Number of extensions: 2058318
Number of successful extensions: 36969
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 751
Number of HSP's successfully gapped in prelim test: 1867
Number of HSP's that attempted gapping in prelim test: 15256
Number of HSP's gapped (non-prelim): 13202
length of query: 531
length of database: 18,247,518
effective HSP length: 107
effective length of query: 424
effective length of database: 14,195,856
effective search space: 6019042944
effective search space used: 6019042944
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (22.0 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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