Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 7657455
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7657455 pescadillo homolog 1, containing BRCT domain [Homo
sapiens]
(588 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7657455 pescadillo homolog 1, containing BRCT domain [Homo sa... 1177 0.0
gi|48255891 protein kinase C substrate 80K-H isoform 2 [Homo sap... 54 4e-07
gi|221219020 NYD-SP11 protein [Homo sapiens] 54 5e-07
gi|17975763 myelin transcription factor 1 [Homo sapiens] 51 3e-06
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 51 3e-06
gi|100816397 MYST histone acetyltransferase (monocytic leukemia)... 51 3e-06
gi|58761548 tau tubulin kinase 1 [Homo sapiens] 50 4e-06
gi|38569484 kinesin family member 21A [Homo sapiens] 50 4e-06
gi|21735569 claspin [Homo sapiens] 50 6e-06
gi|155030232 proline, glutamic acid and leucine rich protein 1 [... 50 8e-06
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] 49 1e-05
gi|55956788 nucleolin [Homo sapiens] 49 1e-05
gi|78042577 MAP7 domain containing 1 [Homo sapiens] 49 1e-05
gi|7662238 apoptotic chromatin condensation inducer 1 [Homo sapi... 49 2e-05
gi|48255889 protein kinase C substrate 80K-H isoform 1 [Homo sap... 49 2e-05
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 49 2e-05
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens] 48 2e-05
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens] 48 2e-05
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens] 48 2e-05
gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens] 48 2e-05
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof... 48 2e-05
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof... 48 2e-05
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof... 48 2e-05
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof... 48 2e-05
gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isof... 48 2e-05
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof... 48 2e-05
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 48 3e-05
gi|113204617 skeletal muscle ryanodine receptor isoform 2 [Homo ... 48 3e-05
gi|113204615 skeletal muscle ryanodine receptor isoform 1 [Homo ... 48 3e-05
gi|51477718 TATA box binding protein-associated factor, RNA poly... 48 3e-05
>gi|7657455 pescadillo homolog 1, containing BRCT domain [Homo
sapiens]
Length = 588
Score = 1177 bits (3045), Expect = 0.0
Identities = 588/588 (100%), Positives = 588/588 (100%)
Query: 1 MGGLEKKKYERGSATNYITRNKARKKLQLSLADFRRLCILKGIYPHEPKHKKKVNKGSTA 60
MGGLEKKKYERGSATNYITRNKARKKLQLSLADFRRLCILKGIYPHEPKHKKKVNKGSTA
Sbjct: 1 MGGLEKKKYERGSATNYITRNKARKKLQLSLADFRRLCILKGIYPHEPKHKKKVNKGSTA 60
Query: 61 ARTFYLIKDIRFLLHEPIVNKFREYKVFVRKLRKAYGKSEWNTVERLKDNKPNYKLDHII 120
ARTFYLIKDIRFLLHEPIVNKFREYKVFVRKLRKAYGKSEWNTVERLKDNKPNYKLDHII
Sbjct: 61 ARTFYLIKDIRFLLHEPIVNKFREYKVFVRKLRKAYGKSEWNTVERLKDNKPNYKLDHII 120
Query: 121 KERYPTFIDALRDLDDALSMCFLFSTFPRTGKCHVQTIQLCRRLTVEFMHYIIAARALRK 180
KERYPTFIDALRDLDDALSMCFLFSTFPRTGKCHVQTIQLCRRLTVEFMHYIIAARALRK
Sbjct: 121 KERYPTFIDALRDLDDALSMCFLFSTFPRTGKCHVQTIQLCRRLTVEFMHYIIAARALRK 180
Query: 181 VFLSIKGIYYQAEVLGQPIVWITPYAFSHDHPTDVDYRVMATFTEFYTTLLGFVNFRLYQ 240
VFLSIKGIYYQAEVLGQPIVWITPYAFSHDHPTDVDYRVMATFTEFYTTLLGFVNFRLYQ
Sbjct: 181 VFLSIKGIYYQAEVLGQPIVWITPYAFSHDHPTDVDYRVMATFTEFYTTLLGFVNFRLYQ 240
Query: 241 LLNLHYPPKLEGQAQAEAKAGEGTYALDSESCMEKLAALSASLARVVVPATEEEAEVDEF 300
LLNLHYPPKLEGQAQAEAKAGEGTYALDSESCMEKLAALSASLARVVVPATEEEAEVDEF
Sbjct: 241 LLNLHYPPKLEGQAQAEAKAGEGTYALDSESCMEKLAALSASLARVVVPATEEEAEVDEF 300
Query: 301 PTDGEMSAQEEDRRKELEAQEKHKKLFEGLKFFLNREVPREALAFIIRSFGGEVSWDKSL 360
PTDGEMSAQEEDRRKELEAQEKHKKLFEGLKFFLNREVPREALAFIIRSFGGEVSWDKSL
Sbjct: 301 PTDGEMSAQEEDRRKELEAQEKHKKLFEGLKFFLNREVPREALAFIIRSFGGEVSWDKSL 360
Query: 361 CIGATYDVTDSRITHQIVDRPGQQTSVIGRCYVQPQWVFDSVNARLLLPVAEYFSGVQLP 420
CIGATYDVTDSRITHQIVDRPGQQTSVIGRCYVQPQWVFDSVNARLLLPVAEYFSGVQLP
Sbjct: 361 CIGATYDVTDSRITHQIVDRPGQQTSVIGRCYVQPQWVFDSVNARLLLPVAEYFSGVQLP 420
Query: 421 PHLSPFVTEKEGDYVPPEKLKLLALQRGEDPGNLNESEEEEEEDDNNEGDGDEEGENEEE 480
PHLSPFVTEKEGDYVPPEKLKLLALQRGEDPGNLNESEEEEEEDDNNEGDGDEEGENEEE
Sbjct: 421 PHLSPFVTEKEGDYVPPEKLKLLALQRGEDPGNLNESEEEEEEDDNNEGDGDEEGENEEE 480
Query: 481 EEDAEAGSEKEEEARLAALEEQRMEGKKPRVMAGTLKLEDKQRLAQEEESEAKRLAIMMM 540
EEDAEAGSEKEEEARLAALEEQRMEGKKPRVMAGTLKLEDKQRLAQEEESEAKRLAIMMM
Sbjct: 481 EEDAEAGSEKEEEARLAALEEQRMEGKKPRVMAGTLKLEDKQRLAQEEESEAKRLAIMMM 540
Query: 541 KKREKYLYQKIMFGKRRKIREANKLAEKRKAHDEAVRSEKKAKKARPE 588
KKREKYLYQKIMFGKRRKIREANKLAEKRKAHDEAVRSEKKAKKARPE
Sbjct: 541 KKREKYLYQKIMFGKRRKIREANKLAEKRKAHDEAVRSEKKAKKARPE 588
>gi|48255891 protein kinase C substrate 80K-H isoform 2 [Homo
sapiens]
Length = 525
Score = 53.9 bits (128), Expect = 4e-07
Identities = 65/255 (25%), Positives = 104/255 (40%), Gaps = 43/255 (16%)
Query: 307 SAQEEDRRKELEAQEKHKKLFEGLKFFLNREVPREALAFIIRSFGGEVSWDKSLCIGATY 366
+ +EE + E EA+E+H+KL+E + +E A + ++ T
Sbjct: 178 TVKEEAEKPEREAKEQHQKLWEEQLAAAKAQQEQELAADAFKELDDDMD--------GTV 229
Query: 367 DVTDSRITHQIVDRPGQ--------QTSVIGRCYVQPQWVFDSVNARLLLPVAEYFSGVQ 418
VT+ + TH +D G Q + G +D V A +
Sbjct: 230 SVTELQ-THPELDTDGDGALSEAEAQALLSGDTQTDATSFYDRVWAAIRDKYRSEALPTD 288
Query: 419 LPPHLSPFVTEKEGDYVPPEKLKLLALQRGEDPGNLNESEEEEEEDDNNEGDGDEEGENE 478
LP +P +TE + + P P + E EEEEEE++ +EE E E
Sbjct: 289 LPAPSAPDLTEPKEEQPPV-------------PSSPTEEEEEEEEEE------EEEAEEE 329
Query: 479 EEEEDAEAGSEKEEEARLAALEEQRMEGKKPRVMAGTLKLEDKQRLAQEEESEAKRLAIM 538
EEEED+E E+ + A A E K P T D + A+ + EA+R ++
Sbjct: 330 EEEEDSEVQGEQPKPASPAE------EDKMPPYDEQTQAFIDAAQEARNKFEEAER-SLK 382
Query: 539 MMKKREKYLYQKIMF 553
M++ + L Q+I F
Sbjct: 383 DMEESIRNLEQEISF 397
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 53.5 bits (127), Expect = 5e-07
Identities = 32/88 (36%), Positives = 48/88 (54%), Gaps = 4/88 (4%)
Query: 445 LQRGEDPGNLNESEEEEEEDDNNEGDGDEEGENEEEEEDAEAGSEKEEEARLAALEEQRM 504
L++ E + E E EEEE+ E +EE E +EEEE E EKEEE + ++++
Sbjct: 2237 LEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEK----KKKKK 2292
Query: 505 EGKKPRVMAGTLKLEDKQRLAQEEESEA 532
E KK V E+K+ + EEE+E+
Sbjct: 2293 EKKKEEVQEKEEVFEEKEEIMSEEETES 2320
Score = 46.2 bits (108), Expect = 8e-05
Identities = 33/128 (25%), Positives = 66/128 (51%), Gaps = 9/128 (7%)
Query: 438 EKLKLLALQRGEDPGNLNESEEEEEEDDNNEGDGDEEGENEE-EEEDAEAGSEKEEEARL 496
EK + L+ + E+ E EEEE ++ E +EEGE ++ E+E+ E +K+E+ +
Sbjct: 2238 EKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKE 2297
Query: 497 AALEEQRMEGKKPRVMAGTLKLEDKQRLAQEEESEAKRLAIMMMKKREKYLYQKIMFGKR 556
E++ + +K +M+ E++ +EE E + ++ REK + +K K+
Sbjct: 2298 EVQEKEEVFEEKEEIMS-----EEETESLSDEEEEEESCSLEEEVDREKEILKK---EKQ 2349
Query: 557 RKIREANK 564
K++E +
Sbjct: 2350 FKLQEQRR 2357
Score = 42.7 bits (99), Expect = 0.001
Identities = 37/141 (26%), Positives = 71/141 (50%), Gaps = 12/141 (8%)
Query: 441 KLLALQRGEDPGNLNESEEEEEEDDNNEGDGDEEGENEEEEEDAEAGSEK---EEEARLA 497
K LA + E ++ E +EEE + EG EE + EEE+A A + EEE +LA
Sbjct: 1712 KELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLA 1771
Query: 498 ALEEQRMEGKKPRVMAGTLKLEDKQRLAQEEESEAKRLAIMMMKKREKYL--------YQ 549
EE ++ K+ E+++RL ++ E ++ + + +KRE+++ +
Sbjct: 1772 QEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEK-KMKLAQKRERWINSMEELTKNK 1830
Query: 550 KIMFGKRRKIREANKLAEKRK 570
I++ K+ +E LA++++
Sbjct: 1831 MILYQKKNLAQEKKNLAQEKE 1851
Score = 40.4 bits (93), Expect = 0.005
Identities = 38/153 (24%), Positives = 69/153 (45%), Gaps = 22/153 (14%)
Query: 454 LNESEEEEEEDDNNEGDGDEEGENEEEEEDAEAGSEK---EEEARLAALEEQRMEGKKPR 510
L+ +E++ D E +EE E EE++ + E+ +EE + A + +R +K R
Sbjct: 1529 LSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKR 1588
Query: 511 VMAGTLKLEDKQRL-------AQEEESEAKRLAIMMMKKRE------KYLYQKIMFGKR- 556
+++++L AQEE A+ + RE K+ ++ +R
Sbjct: 1589 AQEERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRG 1648
Query: 557 -RKIREANKLAEKR----KAHDEAVRSEKKAKK 584
+ +EA KLA+KR K ++ R E+K K
Sbjct: 1649 EKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAK 1681
Score = 38.1 bits (87), Expect = 0.023
Identities = 36/149 (24%), Positives = 70/149 (46%), Gaps = 12/149 (8%)
Query: 446 QRGEDP-----GNLNESEEEEEEDDNNEGDGDE----EGENEEEEEDAEAGSEKEEEARL 496
+RG+ P ++E E EE + E DE E + EEEE+ E E+EEE +
Sbjct: 2204 KRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEE-EV 2262
Query: 497 AALEEQRMEGKKPRVMAGTLKLEDKQRLAQEEESEAKRLAIMMMKKREKYLYQK--IMFG 554
EE+R E ++ + E+K++ +E++ E + + +++E+ + ++
Sbjct: 2263 REEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLS 2322
Query: 555 KRRKIREANKLAEKRKAHDEAVRSEKKAK 583
+ E+ L E+ E ++ EK+ K
Sbjct: 2323 DEEEEEESCSLEEEVDREKEILKKEKQFK 2351
Score = 37.0 bits (84), Expect = 0.051
Identities = 37/119 (31%), Positives = 66/119 (55%), Gaps = 17/119 (14%)
Query: 458 EEEEEEDDNNEGDGD-EEGENEEEEEDAEAGSEKEEEARLAALEEQRMEGKKPRVMAGTL 516
+E+E + E + D EE +EEE + E G EE+ +L A EE+ + ++ ++
Sbjct: 1710 QEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKL-AEEEEALAWQREKLS---- 1764
Query: 517 KLEDKQRLAQEEE---SEAKRLAIMMMKKREKYLYQKIMFGKRRK--IREANKLAEKRK 570
E++ +LAQEEE E ++LA + +EK ++ G++R+ I + KLA+KR+
Sbjct: 1765 --EEETKLAQEEELLIQEKEKLA----QHKEKMPEEEERLGRKREQLIEKKMKLAQKRE 1817
Score = 36.6 bits (83), Expect = 0.066
Identities = 39/162 (24%), Positives = 75/162 (46%), Gaps = 13/162 (8%)
Query: 427 VTEKEGDYVPPEKLKLLALQRGEDPGNLNESEEEEEEDDNNEGDGDEEGENEEEEEDAEA 486
V E+E + E+ + +++ E+ + E+++EE E +E+ E EEE E+
Sbjct: 2262 VREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEE-TES 2320
Query: 487 GSEKEEEARLAALEEQRMEGKKPRVMAGTLKLEDKQRLAQEEESEAKRLAIMMMKKREKY 546
S++EEE +LEE+ K+ + ++KQ QE+ ++ R ++R
Sbjct: 2321 LSDEEEEEESCSLEEEVDREKE-------ILKKEKQFKLQEQRRKSLR-----GRERVLS 2368
Query: 547 LYQKIMFGKRRKIREANKLAEKRKAHDEAVRSEKKAKKARPE 588
+ + + GK R IR + +K A+ ++K PE
Sbjct: 2369 ILRGVPHGKGRAIRLGVLKSPLKKLMSTALEMKEKTPVPVPE 2410
Score = 32.7 bits (73), Expect = 0.96
Identities = 24/94 (25%), Positives = 46/94 (48%), Gaps = 5/94 (5%)
Query: 248 PKLEGQAQAEAKAGEGTYALDSESCMEKLAALSASLARVVVPATEEEAEVDEFPTDGEMS 307
PK + +Q + E ++ + ES +++L + + EEE E +E + E+
Sbjct: 2209 PKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSE-----EEEEREEEEEREEEEVR 2263
Query: 308 AQEEDRRKELEAQEKHKKLFEGLKFFLNREVPRE 341
+EE+R++E E +EK + E K +E +E
Sbjct: 2264 EEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKE 2297
Score = 31.6 bits (70), Expect = 2.1
Identities = 35/160 (21%), Positives = 74/160 (46%), Gaps = 14/160 (8%)
Query: 429 EKEGDYVPPEKLKLLALQRGEDPGNLNESEEEEEEDDNNEGDGDEEGENEEEEEDAEAGS 488
E+EG E + L +R ++ +E+ + + + E EE E
Sbjct: 2179 EEEGGIEEEEVIPFLK-RRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDEL 2237
Query: 489 EKEEEARLAALEEQRMEGKKPRVMAGTLKLEDKQRLAQEEESEAKRLAIMMMKKREKYLY 548
EK+E L++ EE+ E ++ R + E++++ +EEE E K+ ++K E+
Sbjct: 2238 EKQES--LSSEEEEEREEEEEREEEEVREEEEERK--EEEEGEEKQ-----VEKEEEEKK 2288
Query: 549 QKIMFGKRRKIREANKLAEKRKAHDEAVRSEKKAKKARPE 588
+K K+ +++E ++ E++ E + SE++ + E
Sbjct: 2289 KKKKEKKKEEVQEKEEVFEEK----EEIMSEEETESLSDE 2324
Score = 30.0 bits (66), Expect = 6.2
Identities = 21/76 (27%), Positives = 42/76 (55%), Gaps = 1/76 (1%)
Query: 496 LAALEEQRMEGKKPRVMAGTLKLEDKQRLAQEEESEAKRLAIMMMKKREKYLYQKIMFGK 555
LA +EE+ + K+ + E +++L Q E+S AK+ + +K + L + ++ GK
Sbjct: 1888 LAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGK 1947
Query: 556 RRKIREANKLAEKRKA 571
+R +R +A++ KA
Sbjct: 1948 KR-LRGELDIAKEEKA 1962
>gi|17975763 myelin transcription factor 1 [Homo sapiens]
Length = 1121
Score = 51.2 bits (121), Expect = 3e-06
Identities = 30/106 (28%), Positives = 51/106 (48%), Gaps = 5/106 (4%)
Query: 428 TEKEGDYVPPEKLKLLALQRGEDPGNLNESEEEEEEDDNNEGDGDEEGENEEEEEDAEAG 487
TE+ D P + + + G L+ EE+EEE++ E + ++E E EEEEE+ E
Sbjct: 229 TERSQDLCPQSLEDAASEESSKQKGILSHEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEE 288
Query: 488 SEKEEEARLAALEEQRMEGKKPRVMAGTLKLEDKQRLAQEEESEAK 533
E+EEE EE+ E ++ + ED + ++ E +
Sbjct: 289 EEEEEEE-----EEEEEEEEEEEAAPDVIFQEDTSHTSAQKAPELR 329
Score = 50.1 bits (118), Expect = 6e-06
Identities = 28/86 (32%), Positives = 44/86 (51%)
Query: 427 VTEKEGDYVPPEKLKLLALQRGEDPGNLNESEEEEEEDDNNEGDGDEEGENEEEEEDAEA 486
VT + + P+ L+ A + + EEE+EE++ E + +E+ E EEEEE+ E
Sbjct: 227 VTTERSQDLCPQSLEDAASEESSKQKGILSHEEEDEEEEEEEEEEEEDEEEEEEEEEEEE 286
Query: 487 GSEKEEEARLAALEEQRMEGKKPRVM 512
E+EEE EE+ E P V+
Sbjct: 287 EEEEEEEEEEEEEEEEEEEEAAPDVI 312
Score = 41.2 bits (95), Expect = 0.003
Identities = 22/58 (37%), Positives = 32/58 (55%)
Query: 449 EDPGNLNESEEEEEEDDNNEGDGDEEGENEEEEEDAEAGSEKEEEARLAALEEQRMEG 506
ED E EEEEEE++ E + +EE E EEEEE A +E+ + +A + + G
Sbjct: 273 EDEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEAAPDVIFQEDTSHTSAQKAPELRG 330
Score = 39.3 bits (90), Expect = 0.010
Identities = 29/106 (27%), Positives = 50/106 (47%), Gaps = 12/106 (11%)
Query: 430 KEGDYVPPE---KLKLLALQRGEDPGNLNESEEEEEEDDNNEGDGDEEGENEEEEEDAEA 486
++G ++ PE ++ + +R +D + + EE +G E E+EEEEE+ E
Sbjct: 211 EKGLFIQPEDAEEVVEVTTERSQDLCPQSLEDAASEESSKQKGILSHEEEDEEEEEEEEE 270
Query: 487 GSEKEEEARLAALEEQRMEGKKPRVMAGTLKLEDKQRLAQEEESEA 532
E EEE EE+ E ++ E+++ +EEE EA
Sbjct: 271 EEEDEEEEEEEEEEEEEEEEEEE---------EEEEEEEEEEEEEA 307
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 50.8 bits (120), Expect = 3e-06
Identities = 37/106 (34%), Positives = 51/106 (48%), Gaps = 13/106 (12%)
Query: 429 EKEGDYVPPEKLKLLALQRGEDPGNLNESEEEEE---EDDNNEGDGDEEGENEEEEEDAE 485
E+EG+ E+ GE+ E EEE E E++ EG+G+EEGE E EEE+ E
Sbjct: 859 EEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGE 918
Query: 486 AGSEKEEEARLAALEEQRMEGKKPRVMAGTLKLEDKQRLAQEEESE 531
E+E E EE+ EG+ ED + +EEE E
Sbjct: 919 GKGEEEGEEGEGEGEEEEGEGEG----------EDGEGEGEEEEGE 954
Score = 50.1 bits (118), Expect = 6e-06
Identities = 35/89 (39%), Positives = 47/89 (52%), Gaps = 4/89 (4%)
Query: 448 GEDPGNLNESEEEE-EEDDNNEGDGDEEGEN--EEEEEDAEAGSEKEEEARLAALEEQRM 504
GE+ E EEEE EE+ EG+G+EEGE EEEEE G + EE EE+
Sbjct: 981 GEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGE 1040
Query: 505 EGKKPRVMAGTLKLEDKQRLAQEEESEAK 533
E + R G + E+++ +EEE E K
Sbjct: 1041 EEGEEREKEGEGE-ENRRNREEEEEEEGK 1068
Score = 49.3 bits (116), Expect = 1e-05
Identities = 30/86 (34%), Positives = 41/86 (47%)
Query: 448 GEDPGNLNESEEEEEEDDNNEGDGDEEGENEEEEEDAEAGSEKEEEARLAALEEQRMEGK 507
GE+ E EE E E++ EG G+EEGE E EE+ E G + EE E+ EG+
Sbjct: 835 GEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGE 894
Query: 508 KPRVMAGTLKLEDKQRLAQEEESEAK 533
E+ + +EEE E K
Sbjct: 895 GEEEEGEGEGEEEGEGEGEEEEGEGK 920
Score = 46.6 bits (109), Expect = 6e-05
Identities = 32/91 (35%), Positives = 47/91 (51%), Gaps = 7/91 (7%)
Query: 448 GEDPGNLNESEEEEEEDDNNEGDGDEEGENE-EEEEDAEAGSEKEEEARLAAL---EEQR 503
GE E EEEE E + E +G+EEGE E E EE+ E E+EEE + EE
Sbjct: 972 GEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGE 1031
Query: 504 MEGKKPRVMAGTLKLEDKQRLAQEEESEAKR 534
EG++ G + E++++ + EE+ R
Sbjct: 1032 GEGEEEE---GEEEGEEREKEGEGEENRRNR 1059
Score = 45.4 bits (106), Expect = 1e-04
Identities = 30/92 (32%), Positives = 44/92 (47%), Gaps = 4/92 (4%)
Query: 446 QRGEDPGNLNESEEEEEE----DDNNEGDGDEEGENEEEEEDAEAGSEKEEEARLAALEE 501
+ GE E EEEE E ++ EG+G+EEGE E E + E G + EE EE
Sbjct: 838 EEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEE 897
Query: 502 QRMEGKKPRVMAGTLKLEDKQRLAQEEESEAK 533
+ EG+ G + E+ + +EE E +
Sbjct: 898 EEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGE 929
Score = 45.1 bits (105), Expect = 2e-04
Identities = 34/104 (32%), Positives = 48/104 (46%), Gaps = 19/104 (18%)
Query: 449 EDPGNLNESEEEEEEDDNNEGDGDEEGENEEEEEDAE-----------AGSEK--EEEAR 495
E+ G E E + EE++ EG+G EEGE EE E + E AG E+ EEE
Sbjct: 733 EEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGD 792
Query: 496 LAALEEQRMEGKKP------RVMAGTLKLEDKQRLAQEEESEAK 533
EE+ EG+ V G ++ +R +EEE E +
Sbjct: 793 QGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGE 836
Score = 44.7 bits (104), Expect = 2e-04
Identities = 35/109 (32%), Positives = 54/109 (49%), Gaps = 13/109 (11%)
Query: 429 EKEGDYVPPEKLKLLALQRGEDPGNLNESEEEEEEDDNNEGDGDE---EGENEEEEEDAE 485
E EG+ V E+ K + GE +EE+ E++ ++G+G+E EG EE+EE E
Sbjct: 758 EGEGEEVEGEREK----EEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGE 813
Query: 486 A-GSEKEEEARLAALEEQRMEGKKPRVMAGTLKLEDKQRLAQEEESEAK 533
G E EE EE+ EG++ E+++ +EEE E K
Sbjct: 814 VEGGEVEEGKGEREEEEEEGEGEEEEGEG-----EEEEGEGEEEEGEGK 857
Score = 44.7 bits (104), Expect = 2e-04
Identities = 35/102 (34%), Positives = 49/102 (48%), Gaps = 14/102 (13%)
Query: 446 QRGEDPGNLNESEEEE--------EEDDNNEGDGDEEGENEEEEEDAEAGSEKEE---EA 494
++GE+ G+ E EEEE EE EG EEG+ E EEE+ E E+EE E
Sbjct: 785 EKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEE 844
Query: 495 RLAALEEQRMEGK---KPRVMAGTLKLEDKQRLAQEEESEAK 533
EE+ EGK + G + E+ + +EEE E +
Sbjct: 845 EEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGE 886
Score = 44.3 bits (103), Expect = 3e-04
Identities = 29/81 (35%), Positives = 41/81 (50%), Gaps = 1/81 (1%)
Query: 449 EDPGNLNESEEEEEEDDNNEGDG-DEEGENEEEEEDAEAGSEKEEEARLAALEEQRMEGK 507
E+ E EEEE E + EG+G +EEGE + EEE E E+E E EE+ EG+
Sbjct: 827 EEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGE 886
Query: 508 KPRVMAGTLKLEDKQRLAQEE 528
G + E+ + +EE
Sbjct: 887 GEEEGEGEGEEEEGEGEGEEE 907
Score = 44.3 bits (103), Expect = 3e-04
Identities = 31/85 (36%), Positives = 42/85 (49%), Gaps = 8/85 (9%)
Query: 447 RGEDPGNLNESEEEEEEDDNNEGDGDEEGENEEEEEDAEAGSEKEEEARLAALEEQRMEG 506
+GE+ G E E EEEE + DG+ EGE EE E + E EEE EE EG
Sbjct: 920 KGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGE-----EEEGEGEGEEEGEGEG 974
Query: 507 KKPRVMAGTLKLEDKQRLAQEEESE 531
++ G + E+ + +EEE E
Sbjct: 975 EEGE---GEGEEEEGEGEGEEEEGE 996
Score = 44.3 bits (103), Expect = 3e-04
Identities = 32/96 (33%), Positives = 44/96 (45%), Gaps = 16/96 (16%)
Query: 446 QRGEDPGNLNESEEEEEEDDNNEG----------DGDEEGENEEEEEDAEAGSEKEEEAR 495
+ GE G E E E EE+ EG +G+ EGE EE EE+ E E EEE
Sbjct: 951 EEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGE 1010
Query: 496 LAALEEQRMEGKKPRVMAGTLKLEDKQRLAQEEESE 531
EE+ E + G ++ E+ + +EEE E
Sbjct: 1011 GEGEEEEEGE------VEGEVEGEEGEGEGEEEEGE 1040
Score = 43.9 bits (102), Expect = 4e-04
Identities = 34/105 (32%), Positives = 48/105 (45%), Gaps = 4/105 (3%)
Query: 429 EKEGDYVPPEKLKLLALQRGEDPGNLNESEEEEEEDDNNEGDGDEEGENEEEEEDAEAGS 488
E+EG+ E + GED E EE E E + EG+G+ E E E E E+ E
Sbjct: 922 EEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEG 981
Query: 489 EKEEEARLAALEEQRMEGKKPRVMAGTLKLEDKQRLAQEEESEAK 533
E+EE EE EG++ G + E + +EEE E +
Sbjct: 982 EEEEGEGEGEEEEGEEEGEE----EGEGEEEGEGEGEEEEEGEVE 1022
Score = 43.1 bits (100), Expect = 7e-04
Identities = 28/78 (35%), Positives = 39/78 (50%), Gaps = 1/78 (1%)
Query: 456 ESEEEEEEDDNNEGDGDEEGENEEEEEDAEAGSEKEEEARLAALEEQRMEGKKPRVMAGT 515
E EEEE E + EG+G+EE E E EEE+ E E+E E E + EG+
Sbjct: 827 EEEEEEGEGEEEEGEGEEE-EGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEG 885
Query: 516 LKLEDKQRLAQEEESEAK 533
E+ + +EEE E +
Sbjct: 886 EGEEEGEGEGEEEEGEGE 903
Score = 42.7 bits (99), Expect = 0.001
Identities = 33/91 (36%), Positives = 45/91 (49%), Gaps = 10/91 (10%)
Query: 448 GEDPGNLNESEEE-----EEEDDNNEGDGDEEGENEEEEEDAEAGSEKEEEARLAALEEQ 502
GE+ G EEE EEE + EG+G+EE E E E ED E E+EE EE
Sbjct: 904 GEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEE-EGEGEGEDGEGEGEEEEGEWEGEEEEG 962
Query: 503 RMEGKKPRVMAGTLKLEDKQRLAQEEESEAK 533
EG++ G + E+ + +EEE E +
Sbjct: 963 EGEGEE----EGEGEGEEGEGEGEEEEGEGE 989
Score = 42.4 bits (98), Expect = 0.001
Identities = 33/106 (31%), Positives = 51/106 (48%), Gaps = 3/106 (2%)
Query: 429 EKEGDYVPPEKLKLLALQRGEDPGNLNESEEEEEEDDNNEGDGDEEGENEEEEEDAEAGS 488
E+EGD E+ + + GE G E E E+EE + + + + E EEE D G
Sbjct: 740 EEEGDREEEEEKEGEGKEEGE--GEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGE 797
Query: 489 EKEEEARLAALEE-QRMEGKKPRVMAGTLKLEDKQRLAQEEESEAK 533
E+E E R EE +EG + G + E+++ +EEE E +
Sbjct: 798 EEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGE 843
Score = 42.0 bits (97), Expect = 0.002
Identities = 39/115 (33%), Positives = 56/115 (48%), Gaps = 11/115 (9%)
Query: 429 EKEGDYVPPEKLKLLALQRGEDPGNLNESEEEEEEDDNNEGDGD---EEGENEEE----- 480
E+E + EK + ++ GE E EEEEEE + E +G+ EEGE EEE
Sbjct: 798 EEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGK 857
Query: 481 -EEDAEAGSEKEEEARLAALEEQRMEGKKPRVMAGTLKLEDKQRLAQ-EEESEAK 533
EE+ E G E EEE E + EG+ G + E+++ + EEE E +
Sbjct: 858 GEEEGEEG-EGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGE 911
Score = 40.8 bits (94), Expect = 0.004
Identities = 27/82 (32%), Positives = 42/82 (51%), Gaps = 4/82 (4%)
Query: 455 NESEEEEEEDDNNEGDGDEEGENEEEEEDAEAGSEKEEEARLAALEEQRMEGKKPRVMAG 514
N+ EE E+++ EG+ +EEG+ EEEEE G E+ E + E+ +K AG
Sbjct: 724 NQEMEEGGEEEHGEGE-EEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAG 782
Query: 515 TLKL---EDKQRLAQEEESEAK 533
+ E Q +EEE+E +
Sbjct: 783 KEEKGEEEGDQGEGEEEETEGR 804
Score = 40.0 bits (92), Expect = 0.006
Identities = 24/76 (31%), Positives = 39/76 (51%), Gaps = 4/76 (5%)
Query: 456 ESEEEEEEDDNNEGDGDEEGENEEEEEDAEAGSEKEEEARLAALEEQRMEGKKPRVMAGT 515
+ ++E + EG +E GE EEEE D E EKE E + E + +EG++ +
Sbjct: 717 QGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEG-EGEEVEGEREKEEGER 775
Query: 516 LKLEDKQRLAQEEESE 531
K ++R +EE+ E
Sbjct: 776 KK---EERAGKEEKGE 788
Score = 40.0 bits (92), Expect = 0.006
Identities = 32/120 (26%), Positives = 56/120 (46%), Gaps = 5/120 (4%)
Query: 429 EKEGDYVPPEKLKLLALQRGEDPGNLNESEEEEEEDD--NNEGDGDEEGENEEEEEDAEA 486
E EG+ E+ ++ GE+ E EE EEE + EG+G+E N EEEE+ E
Sbjct: 1008 EGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEG 1067
Query: 487 GSE---KEEEARLAALEEQRMEGKKPRVMAGTLKLEDKQRLAQEEESEAKRLAIMMMKKR 543
+ +EE R E +++ K V G K K+ + + + ++ + M ++ +
Sbjct: 1068 KYQETGEEENERQDGEEYKKVSKIKGSVKYGKHKTYQKKSVTNTQGNGKEQRSKMPVQSK 1127
Score = 30.8 bits (68), Expect = 3.6
Identities = 28/122 (22%), Positives = 55/122 (45%), Gaps = 2/122 (1%)
Query: 458 EEEEEEDDNNEGDGDEEGENEEEEEDAEAGSEKEEEARLAALEEQRMEGKKPRVMAGTLK 517
+EE E+ + ++G G+ E E E+E AE K+ + +E+ +K R
Sbjct: 671 DEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEG 730
Query: 518 LEDKQRLAQEEESEAKRLAIMMMKKREKYLYQKIMFGKRRKIREANKLAEKRKAHDEAVR 577
E++ +EEE + + + +E+ +++ G+R K E + E+R +E
Sbjct: 731 GEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVE-GEREK-EEGERKKEERAGKEEKGE 788
Query: 578 SE 579
E
Sbjct: 789 EE 790
Score = 30.4 bits (67), Expect = 4.7
Identities = 34/142 (23%), Positives = 62/142 (43%), Gaps = 15/142 (10%)
Query: 456 ESEEEEEEDDNNEGDGDEEGENEEEEEDAEA-----GSEKEEEARLAALEEQR----MEG 506
+ E E+ E D G+ + GE E+E + E G E+E++ R +++R EG
Sbjct: 671 DEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEG 730
Query: 507 KKPRVMAGTLKLEDKQRLAQEEESEAKRLAIMMMKKREKYLYQKIMFGKRRKIREANKLA 566
+ G + D++ +E+E E K + E+ + G+R+K A K
Sbjct: 731 GEEEHGEGEEEEGDREE-EEEKEGEGKEEGEGEEVEGEREKEE----GERKKEERAGK-E 784
Query: 567 EKRKAHDEAVRSEKKAKKARPE 588
EK + + E++ + R E
Sbjct: 785 EKGEEEGDQGEGEEEETEGRGE 806
>gi|100816397 MYST histone acetyltransferase (monocytic leukemia) 4
[Homo sapiens]
Length = 2073
Score = 50.8 bits (120), Expect = 3e-06
Identities = 33/93 (35%), Positives = 48/93 (51%), Gaps = 13/93 (13%)
Query: 421 PHLSPFVTEKEGDYVPPEKLKLLALQRGEDPGNLNESEEEEEEDDNNEGDG----DEEGE 476
P+ SP + E D + PE+ E+ E EEEEEE + EG G D +G
Sbjct: 1335 PNTSPG-EKPEDDLIKPEE--------EEEEEEEEEEEEEEEEGEEEEGGGNVEKDPDGA 1385
Query: 477 NEEEEEDAEAGSEKEEEARLAALEEQRMEGKKP 509
+E+E+ E +EKE+ ARL EE+ E ++P
Sbjct: 1386 KSQEKEEPEISTEKEDSARLDDHEEEEEEDEEP 1418
Score = 48.9 bits (115), Expect = 1e-05
Identities = 30/95 (31%), Positives = 51/95 (53%), Gaps = 6/95 (6%)
Query: 424 SPFVTEKEGDYVPPEKLKLLALQRGEDPGNLNESEEEEEEDDNNEGDGDEEGENEEEEED 483
SP + + Y+ + + + +RG+ ES EEEEE+++ E + +EE E E+EEE+
Sbjct: 1035 SPAKVQSKNKYLHSPESRPVTGERGQLLELSKESSEEEEEEEDEEEEEEEEEEEEDEEEE 1094
Query: 484 AEAGSEKEEE------ARLAALEEQRMEGKKPRVM 512
E E+EEE RL + ++ K+P V+
Sbjct: 1095 EEEEEEEEEENIQSSPPRLTKPQSVAIKRKRPFVL 1129
Score = 40.8 bits (94), Expect = 0.004
Identities = 26/81 (32%), Positives = 39/81 (48%)
Query: 451 PGNLNESEEEEEEDDNNEGDGDEEGENEEEEEDAEAGSEKEEEARLAALEEQRMEGKKPR 510
P + N S E+ EDD + + +EE E EEEEE+ E E+EE + + ++
Sbjct: 1332 PVSPNTSPGEKPEDDLIKPEEEEEEEEEEEEEEEEEEGEEEEGGGNVEKDPDGAKSQEKE 1391
Query: 511 VMAGTLKLEDKQRLAQEEESE 531
+ + ED RL EE E
Sbjct: 1392 EPEISTEKEDSARLDDHEEEE 1412
Score = 38.1 bits (87), Expect = 0.023
Identities = 23/67 (34%), Positives = 33/67 (49%), Gaps = 9/67 (13%)
Query: 429 EKEGDYVPPEKLKLLALQRGEDPGNLNESEEEEEEDDNNEGDGDEEGENEEEEEDAEAGS 488
EKE + EK ED L++ EEEEEED+ + D + ++E++ A
Sbjct: 1389 EKEEPEISTEK---------EDSARLDDHEEEEEEDEEPSHNEDHDADDEDDSHMESAEV 1439
Query: 489 EKEEEAR 495
EKEE R
Sbjct: 1440 EKEELPR 1446
Score = 37.7 bits (86), Expect = 0.030
Identities = 26/83 (31%), Positives = 43/83 (51%), Gaps = 7/83 (8%)
Query: 448 GEDP-GNLNESEEEEEEDDNNEGDGDEEGENEEEEEDAEAGSEKEEEARLAALEEQRMEG 506
GE P +L + EEEEEE++ +EE E EEEE + E G E+ A +++ E
Sbjct: 1340 GEKPEDDLIKPEEEEEEEE------EEEEEEEEEEGEEEEGGGNVEKDPDGAKSQEKEEP 1393
Query: 507 KKPRVMAGTLKLEDKQRLAQEEE 529
+ + +L+D + +E+E
Sbjct: 1394 EISTEKEDSARLDDHEEEEEEDE 1416
Score = 31.2 bits (69), Expect = 2.8
Identities = 15/44 (34%), Positives = 22/44 (50%)
Query: 449 EDPGNLNESEEEEEEDDNNEGDGDEEGENEEEEEDAEAGSEKEE 492
+DP E+EE E + D ++EEEEE+ E S E+
Sbjct: 1380 KDPDGAKSQEKEEPEISTEKEDSARLDDHEEEEEEDEEPSHNED 1423
Score = 30.4 bits (67), Expect = 4.7
Identities = 17/59 (28%), Positives = 27/59 (45%), Gaps = 2/59 (3%)
Query: 446 QRGEDPGNLNESEEEEEEDDNNEGDGDEEGENEEEEEDAEAGSEKEEEARLAALEEQRM 504
Q E+P E E+ DD+ E +EE E ED +A E + A +E++ +
Sbjct: 1388 QEKEEPEISTEKEDSARLDDHEEE--EEEDEEPSHNEDHDADDEDDSHMESAEVEKEEL 1444
>gi|58761548 tau tubulin kinase 1 [Homo sapiens]
Length = 1321
Score = 50.4 bits (119), Expect = 4e-06
Identities = 25/47 (53%), Positives = 31/47 (65%)
Query: 453 NLNESEEEEEEDDNNEGDGDEEGENEEEEEDAEAGSEKEEEARLAAL 499
N E EEEEEED+ E + +EE E EEEEE+ E E+EEE AA+
Sbjct: 730 NGKEEEEEEEEDEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEAAAAV 776
Score = 48.5 bits (114), Expect = 2e-05
Identities = 24/50 (48%), Positives = 31/50 (62%)
Query: 452 GNLNESEEEEEEDDNNEGDGDEEGENEEEEEDAEAGSEKEEEARLAALEE 501
G E EEEE+E++ E + +EE E EEEEE+ E E+EE A AL E
Sbjct: 731 GKEEEEEEEEDEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEAAAAVALGE 780
Score = 34.3 bits (77), Expect = 0.33
Identities = 18/51 (35%), Positives = 27/51 (52%)
Query: 468 EGDGDEEGENEEEEEDAEAGSEKEEEARLAALEEQRMEGKKPRVMAGTLKL 518
+ +G EE E EEE+E+ E E+EEE EE+ E ++ A + L
Sbjct: 728 QANGKEEEEEEEEDEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEAAAAVAL 778
>gi|38569484 kinesin family member 21A [Homo sapiens]
Length = 1661
Score = 50.4 bits (119), Expect = 4e-06
Identities = 47/165 (28%), Positives = 79/165 (47%), Gaps = 23/165 (13%)
Query: 438 EKLKLLALQRGEDPGNLNESEEEEE---EDDNNE---------GDGDEEGENEEEEEDAE 485
EK K ++ ED + ++ ++EE+ E +NNE D ++E E EEEEED
Sbjct: 552 EKRKKKSVAGKEDNTDTDQEKKEEKGVSERENNELEVEESQEVSDHEDEEEEEEEEEDDI 611
Query: 486 AGSEKEEEARLAALEEQRMEGKKPRVMAGTLKLEDKQRLAQEEESEAKRLAIMMMKKREK 545
G E +E+ + E+ + + T ++ KQ+L E E+ KRL + K
Sbjct: 612 DGGESSDESDSESDEKANYQADLANI---TCEIAIKQKLIDELENSQKRLQTL------K 662
Query: 546 YLYQKIMFGKRRKIREANKLAEKRKAHDEAVR--SEKKAKKARPE 588
Y++ + + KIR+ ++ + +V SE+KAKK R E
Sbjct: 663 KQYEEKLMMLQHKIRDTQLERDQVLQNLGSVESYSEEKAKKVRSE 707
Score = 33.9 bits (76), Expect = 0.43
Identities = 27/124 (21%), Positives = 58/124 (46%), Gaps = 2/124 (1%)
Query: 462 EEDDNNEGDGDEEGENEEEEEDAEAGSEKEEEARLAALEE-QRMEGKKPRVMAGTLKLED 520
E D + G E +EE+ + + EK+ +A L+ Q + + R++ + E
Sbjct: 682 ERDQVLQNLGSVESYSEEKAKKVRSEYEKKLQAMNKELQRLQAAQKEHARLLKNQSQYEK 741
Query: 521 KQRLAQEEESEAKRLAIMMMKKREKYLYQKIMFGKRRKIREANKLAEKRKAHDEAVRSEK 580
+ + Q++ E K+ + +MK+ K +K + R+ RE +L + ++ D +R +
Sbjct: 742 QLKKLQQDVMEMKKTKVRLMKQM-KEEQEKARLTESRRNREIAQLKKDQRKRDHQLRLLE 800
Query: 581 KAKK 584
K+
Sbjct: 801 AQKR 804
>gi|21735569 claspin [Homo sapiens]
Length = 1339
Score = 50.1 bits (118), Expect = 6e-06
Identities = 32/94 (34%), Positives = 50/94 (53%), Gaps = 7/94 (7%)
Query: 438 EKLKLLALQRGEDPGNLNESEEEEEE-DDNNEGDGDEEGENEEEEEDAEAGSEKEEEARL 496
E+ K AL + ++ E EEEEEE D +E DG+E+ E EE+EE+ E EKEEE
Sbjct: 612 ERQKRQALFKLDNEDGFEEEEEEEEEMTDESEEDGEEKVEKEEKEEELEEEEEKEEE--- 668
Query: 497 AALEEQRMEGKKPRVMAGTLKLEDKQRLAQEEES 530
EE+ + + + ++E K ++E+
Sbjct: 669 ---EEEEGNQETAEFLLSSEEIETKDEKEMDKEN 699
Score = 37.0 bits (84), Expect = 0.051
Identities = 36/124 (29%), Positives = 54/124 (43%), Gaps = 15/124 (12%)
Query: 419 LPPHLSPFVTEKEGDYVPPEKLKLLALQRGEDPGNLNESEEEEEED-----DNNEGDGDE 473
+P L+P + P EKL++L + ++ L EE ++ DN +G +E
Sbjct: 573 VPVTLAPKKLDGASHTKPGEKLQVLKAKL-QEAMKLRRFEERQKRQALFKLDNEDGFEEE 631
Query: 474 EGENEE----EEEDAEAGSEKEEEARLAALEEQRMEGKKPRVMAGTLKLEDKQRLAQEEE 529
E E EE EED E EKEE+ EE++ E ++ E + L EE
Sbjct: 632 EEEEEEMTDESEEDGEEKVEKEEKEEELEEEEEKEEEEEEEG-----NQETAEFLLSSEE 686
Query: 530 SEAK 533
E K
Sbjct: 687 IETK 690
Score = 33.5 bits (75), Expect = 0.56
Identities = 30/105 (28%), Positives = 53/105 (50%), Gaps = 10/105 (9%)
Query: 429 EKEGDYVPPEKLKLLALQRGEDPGNLNESEEEEEEDDNNEGDGDEEGENEEEEEDAEAGS 488
EKE P + + LAL G P + E +EEEE D D E +++E+E +++G+
Sbjct: 965 EKESSMGDPME-EALALCSGSFPTDKEEEDEEEEFGDFRLVSNDNEFDSDEDEH-SDSGN 1022
Query: 489 EKEEEARLAALEEQRMEGKKPRVMAGTLKLEDKQRLAQEEESEAK 533
+ ALE+ + + ++ + KL+ + RL + E EA+
Sbjct: 1023 D-------LALEDHE-DDDEEELLKRSEKLKRQMRLRKYLEDEAE 1059
Score = 31.2 bits (69), Expect = 2.8
Identities = 13/34 (38%), Positives = 22/34 (64%)
Query: 292 EEEAEVDEFPTDGEMSAQEEDRRKELEAQEKHKK 325
EEE DE DGE ++E++ +ELE +E+ ++
Sbjct: 634 EEEEMTDESEEDGEEKVEKEEKEEELEEEEEKEE 667
>gi|155030232 proline, glutamic acid and leucine rich protein 1
[Homo sapiens]
Length = 1130
Score = 49.7 bits (117), Expect = 8e-06
Identities = 40/113 (35%), Positives = 59/113 (52%), Gaps = 17/113 (15%)
Query: 420 PPHLSPFVTEKEGDYVPP---EKLKLLALQRGEDPGNLNESEEEEEEDDNNEGDGDEEGE 476
PP L P T G PP E L ++ + ++ E EEEEEE++ E + +EE +
Sbjct: 857 PPQLVPEGTPGGGG--PPALEEDLTVININSSDE-----EEEEEEEEEEEEEEEEEEEED 909
Query: 477 NEEEEEDAEAGSEKEEEARLAALEEQRMEGKKPRVMAGTLKLEDKQRLAQEEE 529
EEEEED E E+EEE EE+ E ++ G L+ E+++ +EEE
Sbjct: 910 FEEEEEDEEEYFEEEEE------EEEEFE-EEFEEEEGELEEEEEEEDEEEEE 955
Score = 38.9 bits (89), Expect = 0.013
Identities = 24/53 (45%), Positives = 32/53 (60%), Gaps = 5/53 (9%)
Query: 449 EDPGNLNESEEEEEEDDNNEGDGDEEGENEEEEEDAEAGSEKEEEARLAALEE 501
ED E EEEEEE+ E + +EEGE EEEEE+ ++EEE L +E+
Sbjct: 915 EDEEEYFEEEEEEEEEFEEEFE-EEEGELEEEEEE----EDEEEEEELEEVED 962
Score = 38.1 bits (87), Expect = 0.023
Identities = 20/54 (37%), Positives = 29/54 (53%)
Query: 456 ESEEEEEEDDNNEGDGDEEGENEEEEEDAEAGSEKEEEARLAALEEQRMEGKKP 509
E EEEE E++ E +G+ E E EEE+E+ E E+ E+ + EG P
Sbjct: 925 EEEEEEFEEEFEEEEGELEEEEEEEDEEEEEELEEVEDLEFGTAGGEVEEGAPP 978
Score = 37.0 bits (84), Expect = 0.051
Identities = 21/48 (43%), Positives = 29/48 (60%)
Query: 458 EEEEEEDDNNEGDGDEEGENEEEEEDAEAGSEKEEEARLAALEEQRME 505
EEEE+E++ E + +EE E EEE E+ E E+EEE EE+ E
Sbjct: 912 EEEEDEEEYFEEEEEEEEEFEEEFEEEEGELEEEEEEEDEEEEEELEE 959
Score = 36.2 bits (82), Expect = 0.086
Identities = 20/57 (35%), Positives = 31/57 (54%)
Query: 449 EDPGNLNESEEEEEEDDNNEGDGDEEGENEEEEEDAEAGSEKEEEARLAALEEQRME 505
E+ + EEEEE+++ + +EE E EEE + E G +EEE EE+ +E
Sbjct: 902 EEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGELEEEEEEEDEEEEEELE 958
Score = 35.0 bits (79), Expect = 0.19
Identities = 25/72 (34%), Positives = 36/72 (50%), Gaps = 6/72 (8%)
Query: 429 EKEGDYVPPEKLKLLALQRGEDPGNLNESEEEEEEDDNNEGDGDEEGENEEEEEDAE--- 485
E+E D+ E+ + + E+ E E EEEE + E + +E+ E EEE E+ E
Sbjct: 905 EEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGELEEEEEEEDEEEEEELEEVEDLE 964
Query: 486 ---AGSEKEEEA 494
AG E EE A
Sbjct: 965 FGTAGGEVEEGA 976
Score = 32.3 bits (72), Expect = 1.2
Identities = 54/275 (19%), Positives = 94/275 (34%), Gaps = 63/275 (22%)
Query: 289 PATEEEAEVDEFPTDGEMSAQEEDRRKELEAQEKHKKLFEGLK-----FFLNREVPREAL 343
PA EE+ V + E +EE+ +E E +E+ ++ FE + +F E E
Sbjct: 872 PALEEDLTVININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEF 931
Query: 344 AFIIRSFGGEVSWDKSLCIGATYDVTDSRITHQIVDRPGQQTSVIGRCYVQPQWVFDSVN 403
GE+ ++ + D ++ + + G
Sbjct: 932 EEEFEEEEGELEEEE--------EEEDEEEEEELEEVEDLEFGTAG-------------- 969
Query: 404 ARLLLPVAEYFSGVQLPPHLSPFVTEKEGDYVPPEKLKLLALQRGEDPGNLNESEEEEEE 463
E G PP L P + PPE + + +PG L E EE E
Sbjct: 970 -------GEVEEGAPPPPTLPPALP-------PPESPPKVQPEPEPEPGLLLEVEEPGTE 1015
Query: 464 DDN--------------NEGDGDEEGENEEEEEDAEAGSEKEEEARLAALEEQRMEGKKP 509
++ ++G+ + EGE+ + E+E A LEE+ +G
Sbjct: 1016 EERGADTAPTLAPEALPSQGEVEREGESPAAGPPPQELVEEEPSAPPTLLEEETEDGSD- 1074
Query: 510 RVMAGTLKLEDKQRLAQEEESEAKRLAIMMMKKRE 544
K++ EEE E + A + +K +
Sbjct: 1075 -------KVQPPPETPAEEEMETETEAEALQEKEQ 1102
Score = 29.6 bits (65), Expect = 8.1
Identities = 30/106 (28%), Positives = 43/106 (40%), Gaps = 19/106 (17%)
Query: 409 PVAEYFSGVQLPPHLSPFVTEKEGDYV----------PPEKLKLLALQRGEDPGNLNESE 458
P E G P L+P +G+ PP++L E+P
Sbjct: 1012 PGTEEERGADTAPTLAPEALPSQGEVEREGESPAAGPPPQELV------EEEPSAPPTLL 1065
Query: 459 EEEEEDDNNEGDGDEEGENEEE---EEDAEAGSEKEEEARLAALEE 501
EEE ED +++ E EEE E +AEA EKE++ A L +
Sbjct: 1066 EEETEDGSDKVQPPPETPAEEEMETETEAEALQEKEQDDTAAMLAD 1111
>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
Length = 245
Score = 49.3 bits (116), Expect = 1e-05
Identities = 34/126 (26%), Positives = 61/126 (48%), Gaps = 7/126 (5%)
Query: 459 EEEEEDDNNEGDGDEEGENEEEEEDAEAGSEKEEEARLAALEEQRMEGKKPRVMAGTLKL 518
E E+E G +++GE ++EE + + ++E E+++ + KK R G
Sbjct: 72 EREKERKRERGKKEKKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKER---GRTSK 128
Query: 519 EDKQRLAQEEESEAKRLAIMMMKKREKYLYQKIMFGKRRKIREANKLAEKRKAHDEAVRS 578
E K+R +EE +R ++R+K +K K RK RE ++ EK + E R
Sbjct: 129 EGKERERKEERKREER----KERERKKEEREKERERKERKKRERKQVGEKEEERKEKERK 184
Query: 579 EKKAKK 584
E+K ++
Sbjct: 185 ERKKRE 190
Score = 49.3 bits (116), Expect = 1e-05
Identities = 36/143 (25%), Positives = 68/143 (47%), Gaps = 11/143 (7%)
Query: 446 QRGEDPGNLNESEEEEEEDDNNEGDGDEEGENEEEEEDAEAGSEKEEEARLAALEEQRME 505
++GE E ++ E +N EG+ E+ + +E++E E +E R EE++ E
Sbjct: 86 KKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERER---KEERKRE 142
Query: 506 GKKPRVMAGTLKLEDKQRLAQEEESEAKRLAIMMMKKREKYLYQKIMFGKRRKIREANKL 565
+K R + + ++R + E E K+ + ++E+ +K K RK RE N+
Sbjct: 143 ERKER------ERKKEEREKERERKERKKRERKQVGEKEEERKEKER--KERKKRERNRK 194
Query: 566 AEKRKAHDEAVRSEKKAKKARPE 588
K++ + R KK +K + E
Sbjct: 195 ERKKERERKERRERKKERKKKEE 217
Score = 46.6 bits (109), Expect = 6e-05
Identities = 41/142 (28%), Positives = 62/142 (43%), Gaps = 13/142 (9%)
Query: 451 PGNLNESEEEEEEDDNNEGDGDEEGENEEEEEDAEAGSEKEEEARLAALEEQRMEGKKPR 510
PG +E E E E + + EG+ E E E + E+E+ R E +R GKK +
Sbjct: 32 PGWQSEIREREREIETRK-----EGKKERESERKKERREREKRKREREKERKRERGKKEK 86
Query: 511 VMAGTLKLEDKQRLAQEEESEAK--RLAIMMMKKREKYLYQKIMFGKRRKIREANKLAEK 568
G K E+++R + E E K KK +K + GK R+ +E K E+
Sbjct: 87 --KGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREER 144
Query: 569 ----RKAHDEAVRSEKKAKKAR 586
RK + E+K +K R
Sbjct: 145 KERERKKEEREKERERKERKKR 166
Score = 44.7 bits (104), Expect = 2e-04
Identities = 38/144 (26%), Positives = 66/144 (45%), Gaps = 9/144 (6%)
Query: 446 QRGEDPGNLNESEEEEEEDDNNEGDGDEEGENEEEEEDAEAGSEKEEEARLAALEEQRME 505
+ GE+ + E++E + EG E E + EE E +KEE + E +R E
Sbjct: 107 KEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREK----ERERKE 162
Query: 506 GKK-PRVMAGTLKLEDKQRLAQEEESEAKRLAIMMMKKREKYLYQKIMFGKRRKIREANK 564
KK R G ++++R +E + KR +K+E+ ++ K RK +E K
Sbjct: 163 RKKRERKQVGE---KEEERKEKERKERKKRERNRKERKKERERKERRERKKERKKKEERK 219
Query: 565 LAEKRKAHDEAVRSEKKAKKARPE 588
E++K R +++ K+ R E
Sbjct: 220 -KERQKDRQTNWREKERGKRERKE 242
Score = 40.4 bits (93), Expect = 0.005
Identities = 32/161 (19%), Positives = 72/161 (44%), Gaps = 6/161 (3%)
Query: 429 EKEGDYVPPEKLKLLALQRGEDPGNLNESEEEEEEDDNNEGDGDEEGENEEEEEDAEAGS 488
EK+G+ E+ + + E+ E E+ ++++ G +EG+ E +E+ +
Sbjct: 85 EKKGERKKEERERKKRRREKENKEG-EEKEKRKKKEKKERGRTSKEGKERERKEERKREE 143
Query: 489 EKEEEARLAALEEQRMEGKKPRVMAGTLKLEDKQRLAQEEESEAKRLAIMMMKKREKYLY 548
KE E + E++R ++ + + ++++R +E + KR +K+E+
Sbjct: 144 RKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERK 203
Query: 549 QKIMFGKRRKIREANKLAEKRKAHD-----EAVRSEKKAKK 584
++ K RK +E K ++ E + E+K +K
Sbjct: 204 ERRERKKERKKKEERKKERQKDRQTNWREKERGKRERKERK 244
Score = 36.2 bits (82), Expect = 0.086
Identities = 26/88 (29%), Positives = 39/88 (44%), Gaps = 11/88 (12%)
Query: 501 EQRMEGKKPRVMAGTLKLEDKQRLAQEEESEAKRLAIMMMKKREKYLYQKIMFGKRRKIR 560
E R EGKK R + ++++ +E E E KR K+EK G+R+K
Sbjct: 46 ETRKEGKKERESERKKERREREKRKREREKERKR----ERGKKEKK-------GERKKEE 94
Query: 561 EANKLAEKRKAHDEAVRSEKKAKKARPE 588
K + K + E EK+ KK + E
Sbjct: 95 RERKKRRREKENKEGEEKEKRKKKEKKE 122
>gi|55956788 nucleolin [Homo sapiens]
Length = 710
Score = 48.9 bits (115), Expect = 1e-05
Identities = 32/104 (30%), Positives = 53/104 (50%), Gaps = 13/104 (12%)
Query: 428 TEKEGDYVPPEKLKLLALQRGEDPGNLNESEEEEEEDDNNEGDGDEEGENEEEEEDAEAG 487
+E+E P K K A N+ E E+EEE+D++ + D DE+ E++++E+D E
Sbjct: 206 SEEEAMETTPAKGKKAAKVVPVKAKNVAEDEDEEEDDEDEDDDDDEDDEDDDDEDDEEEE 265
Query: 488 SEKEEEARLAALEEQRMEGKKPRVMAGTLKLEDKQRLAQEEESE 531
E+EEE + GK+ + MA KQ+ A E + +
Sbjct: 266 EEEEEE------PVKEAPGKRKKEMA-------KQKAAPEAKKQ 296
Score = 48.1 bits (113), Expect = 2e-05
Identities = 30/88 (34%), Positives = 50/88 (56%), Gaps = 11/88 (12%)
Query: 430 KEGDYVPPEKLKLLALQRGEDPGNLNESEEEEEEDDNNEGDGDEEGENEEEEEDAE---- 485
K+ V P K K +A E+ ++ +E++++D+++E D DE+ E EEEEE+ E
Sbjct: 219 KKAAKVVPVKAKNVAEDEDEEE---DDEDEDDDDDEDDEDDDDEDDEEEEEEEEEEPVKE 275
Query: 486 -AGSEKEEEARLAALEE---QRMEGKKP 509
G K+E A+ A E Q++EG +P
Sbjct: 276 APGKRKKEMAKQKAAPEAKKQKVEGTEP 303
Score = 38.9 bits (89), Expect = 0.013
Identities = 27/120 (22%), Positives = 55/120 (45%), Gaps = 21/120 (17%)
Query: 430 KEGDYVPPEKLKLLALQRGEDPGNLNESEEEEEEDDNNEGDGD----------------- 472
K+G +P + K + ED + + EE+E+D+ + D D
Sbjct: 124 KKGAAIPAKGAKNGKNAKKEDSDEEEDDDSEEDEEDDEDEDEDEDEIEPAAMKAAAAAPA 183
Query: 473 -EEGENEEEEEDAEAGSEKEEEARLAALEEQRMEGKKPRVMAGTLKLEDKQRLAQEEESE 531
E+ ++E++E+D + ++E+++ A+E +GKK A + ++ K E+E E
Sbjct: 184 SEDEDDEDDEDDEDDDDDEEDDSEEEAMETTPAKGKK---AAKVVPVKAKNVAEDEDEEE 240
Score = 37.4 bits (85), Expect = 0.039
Identities = 17/66 (25%), Positives = 38/66 (57%)
Query: 436 PPEKLKLLALQRGEDPGNLNESEEEEEEDDNNEGDGDEEGENEEEEEDAEAGSEKEEEAR 495
P +K + + ++ N + + +EEEDD++E D +++ + +E+E++ E + K A
Sbjct: 122 PGKKGAAIPAKGAKNGKNAKKEDSDEEEDDDSEEDEEDDEDEDEDEDEIEPAAMKAAAAA 181
Query: 496 LAALEE 501
A+ +E
Sbjct: 182 PASEDE 187
Score = 35.0 bits (79), Expect = 0.19
Identities = 20/88 (22%), Positives = 39/88 (44%), Gaps = 23/88 (26%)
Query: 429 EKEGDYVPPEKLKLLALQRGEDPGNLNESEEEEEEDDNNEGDGDEE-------------- 474
+++ D + P +K A + + + E++E++DD+ E D +EE
Sbjct: 164 DEDEDEIEPAAMKAAAAAPASEDEDDEDDEDDEDDDDDEEDDSEEEAMETTPAKGKKAAK 223
Query: 475 ---------GENEEEEEDAEAGSEKEEE 493
E+E+EEED E + ++E
Sbjct: 224 VVPVKAKNVAEDEDEEEDDEDEDDDDDE 251
>gi|78042577 MAP7 domain containing 1 [Homo sapiens]
Length = 841
Score = 48.9 bits (115), Expect = 1e-05
Identities = 43/169 (25%), Positives = 77/169 (45%), Gaps = 12/169 (7%)
Query: 420 PPHLSPFVTEKE---GDYVPPEKLKLLALQRGEDPGNLNESEEEEEEDDNNEGDGDEEGE 476
PP +P VT + G E +LLA +R + E E EE++ + + D+
Sbjct: 577 PPAPAPPVTPSKPMAGTTDREEATRLLAEKRRQ----AREQREREEQERRLQAERDKRMR 632
Query: 477 NEEEEEDAEAGSEKEEEARLAALEEQRMEGKKPRVMAGTLKLEDKQRLAQEEESEAKRLA 536
E+ +AEA +E+E EAR +E R + A + E Q+ +E E+ ++ A
Sbjct: 633 EEQLAREAEARAEREAEARRREEQEAR-----EKAQAEQEEQERLQKQKEEAEARSREEA 687
Query: 537 IMMMKKREKYLYQKIMFGKRRKIREANKLAEKRKAHDEAVRSEKKAKKA 585
+REK+ Q+ + R+ R + RK+ + ++ +K+A
Sbjct: 688 ERQRLEREKHFQQQEQERQERRKRLEEIMKRTRKSEVSETKQKQDSKEA 736
Score = 35.8 bits (81), Expect = 0.11
Identities = 23/65 (35%), Positives = 35/65 (53%), Gaps = 5/65 (7%)
Query: 479 EEEEDAEAGSEKEEEARLAALEEQRMEGKKPRVMAGTLKLEDKQRLAQEEESEAKRLAIM 538
E+EE A+A EK+ + R LEEQR++ ++ R LE++QR E+ E AI
Sbjct: 162 EKEEKAKALREKQLQERRRRLEEQRLKAEQRRA-----ALEERQRQKLEKNKERYEAAIQ 216
Query: 539 MMKKR 543
K+
Sbjct: 217 RSVKK 221
Score = 30.8 bits (68), Expect = 3.6
Identities = 42/189 (22%), Positives = 73/189 (38%), Gaps = 33/189 (17%)
Query: 420 PPHLSPFVTEKEGDYVPPEKLKLLALQRGEDPGNLNESEEEEEEDDNNEGD-GDEEGENE 478
PP +S V + D P K N S++ E ++ G G +
Sbjct: 37 PPPMSALVPDTPPDTPPAMK-------------NATSSKQLPLEPESPSGQVGPRPAPPQ 83
Query: 479 EEEEDAEAGSEKEEEARLA---ALEEQRMEGKKPRVMAGT---------LKLEDKQRLAQ 526
EE +EA S + A +R P + + K ++ +LA+
Sbjct: 84 EESPSSEAKSRGPTPPAMGPRDARPPRRSSQPSPTAVPASDSPPTKQEVKKAGERHKLAK 143
Query: 527 EEESE------AKRLAIMMMKKREKYLYQKIMFGKRRKIREANKLAEKRKAH-DEAVRSE 579
E E AK+ + +++ K L +K + +RR++ E AE+R+A +E R +
Sbjct: 144 ERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLKAEQRRAALEERQRQK 203
Query: 580 KKAKKARPE 588
+ K R E
Sbjct: 204 LEKNKERYE 212
>gi|7662238 apoptotic chromatin condensation inducer 1 [Homo
sapiens]
Length = 1341
Score = 48.5 bits (114), Expect = 2e-05
Identities = 35/155 (22%), Positives = 71/155 (45%), Gaps = 3/155 (1%)
Query: 429 EKEGDYVPPEKLKLLALQRGEDPGNLNESEEEEEEDDNNEGDGDEEGENEEEEEDAEAGS 488
E+E D P + + R E EEEEEEDD E +GD+EG+ E +
Sbjct: 247 EEEEDQETPSRNLRVRADRNLKTEEEEEEEEEEEEDDEEE-EGDDEGQKSREAPILKEFK 305
Query: 489 EKEEEARLAALEEQRMEGKKPRVMAGTLKLEDKQRLAQEEESEAKRLAIMMMKKREKYLY 548
E+ EE + ++ + M ++P+ + ++ ++ + EA++ + ++ ++
Sbjct: 306 EEGEE--IPRVKPEEMMDERPKTRSQEQEVLERGGRFTRSQEEARKSHLARQQQEKEMKT 363
Query: 549 QKIMFGKRRKIREANKLAEKRKAHDEAVRSEKKAK 583
+ + R+I+ + L EK K+ +E + K
Sbjct: 364 TSPLEEEEREIKSSQGLKEKSKSPSPPRLTEDRKK 398
Score = 30.4 bits (67), Expect = 4.7
Identities = 33/137 (24%), Positives = 60/137 (43%), Gaps = 9/137 (6%)
Query: 457 SEEEEEEDDNNEG----DGDEEGENEEEEEDAEAGSEKEEEAR---LAALEEQRMEGKKP 509
SE E + D EG + +E + E SEK+E+A+ A L + K
Sbjct: 1161 SEREWDRDKVREGPRSRSRSRDRRRKERAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKA 1220
Query: 510 RVMAGTLKLEDKQRLAQEEESEAKRLAIMMMKKREKYLYQKIMFGKRRKIREANKLAEKR 569
L L D Q + Q+E A+R A K+R++ ++ ++ RE N+ E+
Sbjct: 1221 APCIYWLPLTDSQ-IVQKEAERAER-AKEREKRRKEQEEEEQKEREKEAERERNRQLERE 1278
Query: 570 KAHDEAVRSEKKAKKAR 586
K + + +++ ++ R
Sbjct: 1279 KRREHSRERDRERERER 1295
>gi|48255889 protein kinase C substrate 80K-H isoform 1 [Homo
sapiens]
Length = 528
Score = 48.5 bits (114), Expect = 2e-05
Identities = 65/255 (25%), Positives = 104/255 (40%), Gaps = 40/255 (15%)
Query: 307 SAQEEDRRKELEAQEKHKKLFEGLKFFLNREVPREALAFIIRSFGGEVSWDKSLCIGATY 366
+ +EE + E EA+E+H+KL+E + +E A + ++ T
Sbjct: 178 TVKEEAEKPEREAKEQHQKLWEEQLAAAKAQQEQELAADAFKELDDDMD--------GTV 229
Query: 367 DVTDSRITHQIVDRPGQ--------QTSVIGRCYVQPQWVFDSVNARLLLPVAEYFSGVQ 418
VT+ + TH +D G Q + G +D V A +
Sbjct: 230 SVTELQ-THPELDTDGDGALSEAEAQALLSGDTQTDATSFYDRVWAAIRDKYRSEALPTD 288
Query: 419 LPPHLSPFVTEKEGDYVPPEKLKLLALQRGEDPGNLNESEEEEEEDDNNEGDGDEEGENE 478
LP +P +TE P E+ + P + +EEEEEE++ E EE E E
Sbjct: 289 LPAPSAPDLTE------PKEE---------QPPVPSSPTEEEEEEEEEEE----EEAEEE 329
Query: 479 EEEEDAEAGSEKEEEARLAALEEQRMEGKKPRVMAGTLKLEDKQRLAQEEESEAKRLAIM 538
EEEED+E + A+ E E K P T D + A+ + EA+R ++
Sbjct: 330 EEEEDSEEAPPPLSPPQPASPAE---EDKMPPYDEQTQAFIDAAQEARNKFEEAER-SLK 385
Query: 539 MMKKREKYLYQKIMF 553
M++ + L Q+I F
Sbjct: 386 DMEESIRNLEQEISF 400
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 48.5 bits (114), Expect = 2e-05
Identities = 40/138 (28%), Positives = 72/138 (52%), Gaps = 8/138 (5%)
Query: 457 SEEEEEEDDNNEGDGDEEGENEE-EEEDAEAGSEKEEEARLAALEEQRMEGKKPRVMA-- 513
S EE ++++ E DE +E+ EEED E + E ARL A E +R++ ++ + +A
Sbjct: 234 SSEEPKQEEEREQGSDEISHHEKMEEEDKERA--EAERARLEAEERERIKAEQDKKIADE 291
Query: 514 -GTLKLEDKQRLAQEEESEA-KRLAIMMMKKREKYLYQKIMFGKRRKIREANKLAEKRK- 570
++ E+K + E EA +R + +KR Q+I ++R E ++ E+ K
Sbjct: 292 RARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKR 351
Query: 571 AHDEAVRSEKKAKKARPE 588
A +E R +++ K+A E
Sbjct: 352 AAEERQRIKEEEKRAAEE 369
Score = 43.9 bits (102), Expect = 4e-04
Identities = 32/147 (21%), Positives = 71/147 (48%), Gaps = 3/147 (2%)
Query: 438 EKLKLLALQRGEDPGNLNESEEEEEEDDNNEGDGDEEGENEEEEEDAEAGSEKEEEARLA 497
E+ K A +R + EE + E EE + EE+ +A + EE+ R
Sbjct: 333 EEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKA--KVEEQKRNK 390
Query: 498 ALEEQRMEGKKPRVMAGTLKLEDKQRLAQEEESEAKRLAIMMMKKREKYLYQKIMFGKRR 557
LEE++ ++ ++ ++ + + + E++++ +L ++KK+ + K+ KR
Sbjct: 391 QLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQ-AKRE 449
Query: 558 KIREANKLAEKRKAHDEAVRSEKKAKK 584
K++E +K + DE ++ +K+ K+
Sbjct: 450 KLQEDKPTFKKEEIKDEKIKKDKEPKE 476
Score = 43.1 bits (100), Expect = 7e-04
Identities = 41/169 (24%), Positives = 83/169 (49%), Gaps = 31/169 (18%)
Query: 438 EKLKLLALQRG----EDPGNLNESE---------EEEEEDDNNEGDGDEEGENEEEEEDA 484
E+ +++L+ G E+P E E E+ EE+D + + EE E
Sbjct: 221 EETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERI 280
Query: 485 EAGSEK---EEEARLAALEEQRMEGKKPRVMAGTLKLEDKQRLAQEEESEAKRLAIMMMK 541
+A +K +E AR+ A E+ + ++ R + E+++R+ +EE+ A+ +K
Sbjct: 281 KAEQDKKIADERARIEAEEKAAAQERERR------EAEERERMREEEKRAAEER--QRIK 332
Query: 542 KREKYLYQKIMFGKRRKIREANKLA--EKRKAHDEAVRSEKKAKKARPE 588
+ EK + +R++I+E K A E+++ +E R+ ++ ++AR E
Sbjct: 333 EEEKRAAE-----ERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAE 376
Score = 42.0 bits (97), Expect = 0.002
Identities = 33/158 (20%), Positives = 75/158 (47%), Gaps = 6/158 (3%)
Query: 429 EKEGDYVPPEKLKLLALQRGEDPGNLNESEEEEEEDDNNEGDGDEEGENEEEEE-DAEAG 487
E++ + E+ +L A E+ + ++++ D+ + +E+ +E E +AE
Sbjct: 259 EEDKERAEAERARLEA----EERERIKAEQDKKIADERARIEAEEKAAAQERERREAEER 314
Query: 488 SEKEEEARLAALEEQRMEGKKPRVMAGTLKLEDKQRLAQEEESEAKRLAIMMMKKREKYL 547
EE + AA E QR++ ++ R +++++++ A EE K ++R++
Sbjct: 315 ERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRAR 374
Query: 548 YQKIMFGKRRKIREANKLAEKRKAHDEA-VRSEKKAKK 584
++ K + + +L EK+ A E ++ EK +K
Sbjct: 375 AEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQK 412
Score = 37.7 bits (86), Expect = 0.030
Identities = 32/143 (22%), Positives = 71/143 (49%), Gaps = 10/143 (6%)
Query: 456 ESEEEEEEDDNNEGDGDEEGENEEEEEDAEAGSEKEEEARLAALEEQRMEGKKPRV---- 511
+ ++E+EE++ + GEN+ E E +E +EE + +L+ ++ ++P+
Sbjct: 185 KEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEER 244
Query: 512 MAGTLKLEDKQRLAQE--EESEAKRLAI-MMMKKREKYLYQKIMFGKRRKIREANKLA-- 566
G+ ++ +++ +E E +EA+R + ++R K K + +R +I K A
Sbjct: 245 EQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQ 304
Query: 567 -EKRKAHDEAVRSEKKAKKARPE 588
+R+ +E R ++ K+A E
Sbjct: 305 ERERREAEERERMREEEKRAAEE 327
Score = 32.3 bits (72), Expect = 1.2
Identities = 44/191 (23%), Positives = 78/191 (40%), Gaps = 34/191 (17%)
Query: 429 EKEGDYVPPEKLKLLALQRGEDPGNLNESEEEEEEDDNNEG---------------DGDE 473
+KE D + L +R ++ NE+ E+EE+ ++ + D
Sbjct: 118 QKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDW 177
Query: 474 EGENEEEEEDAEAGSEKEEEARLAAL---------EEQRMEGKKPRVMA----GTLKLED 520
E ++ED E E+EE+ + ++ EE+ E ++ V+ G + E+
Sbjct: 178 RDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEE 237
Query: 521 KQRLAQEEESEAKRLAIMMMKKREKYLYQKIMFGKRR---KIREANKLAEKRKAHDEAVR 577
+ QEEE E I +K E+ ++ + R + RE K + +K DE R
Sbjct: 238 PK---QEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERAR 294
Query: 578 SEKKAKKARPE 588
E + K A E
Sbjct: 295 IEAEEKAAAQE 305
Score = 30.8 bits (68), Expect = 3.6
Identities = 26/90 (28%), Positives = 49/90 (54%), Gaps = 4/90 (4%)
Query: 497 AALEEQRMEGKKPRVMAGTLKLEDKQRLAQEEESEAKRLAIMMMKKREKYLYQKIMFGKR 556
A+++ + EG P+V AG +LE+ +R E ESE + K++E L + + KR
Sbjct: 517 ASVDTKEAEGA-PQVEAGK-RLEELRRRRGETESE--EFEKLKQKQQEAALELEELKKKR 572
Query: 557 RKIREANKLAEKRKAHDEAVRSEKKAKKAR 586
+ R+ + E+R+ +EA R ++ ++ R
Sbjct: 573 EERRKVLEEEEQRRKQEEADRKLREEEEKR 602
Score = 29.6 bits (65), Expect = 8.1
Identities = 23/102 (22%), Positives = 43/102 (42%), Gaps = 6/102 (5%)
Query: 443 LALQRGEDPGNLNESEEEEEEDDNNEGDGDEEGENEEEEEDAEAGSEKEEEARLAALEEQ 502
+A QR +D EEE + + + +EEE + + E A+ + +E+
Sbjct: 25 IAYQRNDD------DEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEE 78
Query: 503 RMEGKKPRVMAGTLKLEDKQRLAQEEESEAKRLAIMMMKKRE 544
+ G + +RLA+ EE KRL + +++E
Sbjct: 79 AKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKE 120
Score = 29.6 bits (65), Expect = 8.1
Identities = 27/147 (18%), Positives = 62/147 (42%), Gaps = 7/147 (4%)
Query: 445 LQRGEDPGNLNESEEEEEEDDNNEGDGDEEGENEEEEEDAEAGSEKEEEARLAALEEQRM 504
L++ + L E +++ ++ + +EE ++EE D + E+E+ +E +R
Sbjct: 554 LKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRA 613
Query: 505 EGKKPRVMAGTLKLEDKQRLAQEEESEAKRLAIMMMKKREKYLYQKIMFGKRRKIRE--- 561
E + R L D ++ + + L I ++R ++L + + K
Sbjct: 614 EAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKI---EERAEFLNKSVQKSSGVKSTHQAA 670
Query: 562 -ANKLAEKRKAHDEAVRSEKKAKKARP 587
+K+ + + + A+ K AK +P
Sbjct: 671 IVSKIDSRLEQYTSAIEGTKSAKPTKP 697
>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
Length = 770
Score = 48.1 bits (113), Expect = 2e-05
Identities = 33/88 (37%), Positives = 47/88 (53%), Gaps = 6/88 (6%)
Query: 450 DPGNLNESEEEEEEDDNNEGDGDEEGENEEEEED---AEAGSEKEEEARLAALE--EQRM 504
+ G+ +E EEEEEE++ EG EE E EEEEE+ E GS EE + +A E E+ M
Sbjct: 273 ESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEM 332
Query: 505 EGKKPRVMAGTLKLEDKQRLAQEE-ESE 531
+ R L + + R ++ ESE
Sbjct: 333 SEDEERENENHLLVVPESRFDRDSGESE 360
Score = 40.4 bits (93), Expect = 0.005
Identities = 21/87 (24%), Positives = 39/87 (44%)
Query: 457 SEEEEEEDDNNEGDGDEEGENEEEEEDAEAGSEKEEEARLAALEEQRMEGKKPRVMAGTL 516
S E ++ G +EE E EEEEE+ E EEE EE+ +
Sbjct: 265 SSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSA 324
Query: 517 KLEDKQRLAQEEESEAKRLAIMMMKKR 543
+ ++ ++++EE E + +++ + R
Sbjct: 325 EEVSEEEMSEDEERENENHLLVVPESR 351
Score = 38.5 bits (88), Expect = 0.017
Identities = 38/186 (20%), Positives = 80/186 (43%), Gaps = 20/186 (10%)
Query: 423 LSPFVTEKEGDYVPPEKLKLLALQRGEDPGNLNESEEEEEEDD--------NNEGDGDEE 474
L + EK+ EK ++ L+ +D + +S EE E D N+ ++
Sbjct: 13 LDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDS 72
Query: 475 GENEEEEEDAEAGSEKEEEARLAALEEQRMEGKKPRVMAGTLK----------LEDKQRL 524
E+ EE+D+ A ++ +R + ++ E +K + +K E++ +
Sbjct: 73 MEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKWKHARVKEREHERRKRHREEQDKA 132
Query: 525 AQEEESEAKRLAIMMMKKREKYLYQKI--MFGKRRKIREANKLAEKRKAHDEAVRSEKKA 582
+E E + +R +RE+ +++ + RK+RE K ++K + +K
Sbjct: 133 RREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKE 192
Query: 583 KKARPE 588
++AR E
Sbjct: 193 REARRE 198
Score = 36.6 bits (83), Expect = 0.066
Identities = 20/64 (31%), Positives = 27/64 (42%), Gaps = 4/64 (6%)
Query: 446 QRGEDPGNLNESEEEEEEDDNNEGDGDEEGE----NEEEEEDAEAGSEKEEEARLAALEE 501
+ G E EEEEEE++ G EE E EE+ E+E E L + E
Sbjct: 290 EEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPE 349
Query: 502 QRME 505
R +
Sbjct: 350 SRFD 353
>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
Length = 780
Score = 48.1 bits (113), Expect = 2e-05
Identities = 33/88 (37%), Positives = 47/88 (53%), Gaps = 6/88 (6%)
Query: 450 DPGNLNESEEEEEEDDNNEGDGDEEGENEEEEED---AEAGSEKEEEARLAALE--EQRM 504
+ G+ +E EEEEEE++ EG EE E EEEEE+ E GS EE + +A E E+ M
Sbjct: 283 ESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEM 342
Query: 505 EGKKPRVMAGTLKLEDKQRLAQEE-ESE 531
+ R L + + R ++ ESE
Sbjct: 343 SEDEERENENHLLVVPESRFDRDSGESE 370
Score = 40.4 bits (93), Expect = 0.005
Identities = 21/87 (24%), Positives = 39/87 (44%)
Query: 457 SEEEEEEDDNNEGDGDEEGENEEEEEDAEAGSEKEEEARLAALEEQRMEGKKPRVMAGTL 516
S E ++ G +EE E EEEEE+ E EEE EE+ +
Sbjct: 275 SSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSA 334
Query: 517 KLEDKQRLAQEEESEAKRLAIMMMKKR 543
+ ++ ++++EE E + +++ + R
Sbjct: 335 EEVSEEEMSEDEERENENHLLVVPESR 361
Score = 36.6 bits (83), Expect = 0.066
Identities = 20/64 (31%), Positives = 27/64 (42%), Gaps = 4/64 (6%)
Query: 446 QRGEDPGNLNESEEEEEEDDNNEGDGDEEGE----NEEEEEDAEAGSEKEEEARLAALEE 501
+ G E EEEEEE++ G EE E EE+ E+E E L + E
Sbjct: 300 EEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPE 359
Query: 502 QRME 505
R +
Sbjct: 360 SRFD 363
Score = 34.3 bits (77), Expect = 0.33
Identities = 42/198 (21%), Positives = 79/198 (39%), Gaps = 34/198 (17%)
Query: 423 LSPFVTEKEGDYVPPEKLKLLALQRGEDPGNLNESEEEEEEDD--------NNEGDGDEE 474
L + EK+ EK ++ L+ +D + +S EE E D N+ ++
Sbjct: 13 LDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDS 72
Query: 475 GENEEEEEDAEAGSEKEEEARLAALEEQRMEGKKPRVM-----------AGTLKLEDKQR 523
E+ EE+D+ A ++ +R + ++ E +K + A + E ++R
Sbjct: 73 MEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKCRHHSHSAEGGKHARVKEREHERR 132
Query: 524 LAQEEESEAKRLAIMMMKKRE-------------KYLYQKIMFGKRRKIREANKLAEKRK 570
EE + R K+RE + L +K + RK+RE K ++K
Sbjct: 133 KRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRE--RERKMREQQKEQREQK 190
Query: 571 AHDEAVRSEKKAKKARPE 588
+ +K ++AR E
Sbjct: 191 ERERRAEERRKEREARRE 208
>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
Length = 2454
Score = 48.1 bits (113), Expect = 2e-05
Identities = 36/117 (30%), Positives = 54/117 (46%), Gaps = 14/117 (11%)
Query: 429 EKEGDYVPPEKLKLLALQRGEDPGNLNESEEEEEEDDNNEGDGDEEGENEEEEEDAEAGS 488
E + Y +K + + +Q N + SEEEEEE + E +EE E EEEEED S
Sbjct: 1376 ENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEE---EEEEEEEEEEEDENDDS 1432
Query: 489 EKEEEARLAALEEQRMEGKKPRVMAGTLKLEDKQRLAQEEESEAKRLAIMMMKKREK 545
+ + R KK R + KL + + A +EE E ++ ++REK
Sbjct: 1433 KSPGKGR-----------KKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREK 1478
Score = 38.9 bits (89), Expect = 0.013
Identities = 30/143 (20%), Positives = 57/143 (39%), Gaps = 13/143 (9%)
Query: 457 SEEEEEEDDNNEGDGDEEGENEEE-------------EEDAEAGSEKEEEARLAALEEQR 503
SE+ E+ D G +E E+E+E EE+ + +K++ R+ E+
Sbjct: 1338 SEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSS 1397
Query: 504 MEGKKPRVMAGTLKLEDKQRLAQEEESEAKRLAIMMMKKREKYLYQKIMFGKRRKIREAN 563
E K K E+++ +EEE E + + +KI+ + + N
Sbjct: 1398 SENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQN 1457
Query: 564 KLAEKRKAHDEAVRSEKKAKKAR 586
L E+ + E++ +K R
Sbjct: 1458 ALKEEEERRKRIAEREREREKLR 1480
Score = 38.5 bits (88), Expect = 0.017
Identities = 42/174 (24%), Positives = 69/174 (39%), Gaps = 25/174 (14%)
Query: 425 PFVTEKEGDYVPPEKLKLLALQRGEDPGNLNESEEEEEEDDNNEGDGDEEGENEEEEEDA 484
P + + D PE + E NL+ E+ +D+ EG +NEE D
Sbjct: 1217 PVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDE 1276
Query: 485 EAGSEKEEEARLAALEEQRMEGKKPRVMAGTLKLEDKQRLAQEEESEAKRLAIMMMKKRE 544
EA ++ E+ + E KKPR L+ K ++ E E K+ K +E
Sbjct: 1277 EAKNQVNSES-----DSDSEESKKPRYRHRLLR--HKLTVSDGESGEEKK-----TKPKE 1324
Query: 545 KYLYQKIMFGKRRKI----------REANKLAEKRKAHDEAVRSEKKAKKARPE 588
++++ RRK+ +E+ E ++ DE + AKKA E
Sbjct: 1325 ---HKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELE 1375
Score = 34.7 bits (78), Expect = 0.25
Identities = 35/174 (20%), Positives = 68/174 (39%), Gaps = 27/174 (15%)
Query: 433 DYVPPEKLKLLALQRGEDPGNLNESEEEEEEDDNNEGDGDEEGENEEEEE---------- 482
D P E K Q E+PG +EE + N+E D D E +
Sbjct: 1255 DDEPEEGKKRTGKQNEENPG-----DEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTV 1309
Query: 483 -DAEAGSEKEEEARLAALEEQRMEGKKPRVMAGTLKLED-------KQRLAQEEESEAKR 534
D E+G EK+ + + E + ++G+ R ++ + + +++ E+ + R
Sbjct: 1310 SDGESGEEKKTKPK----EHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPR 1365
Query: 535 LAIMMMKKREKYLYQKIMFGKRRKIREANKLAEKRKAHDEAVRSEKKAKKARPE 588
+ E+ KRR+I+ + + K++ E EK+ ++ E
Sbjct: 1366 TRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEE 1419
>gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]
Length = 2492
Score = 48.1 bits (113), Expect = 2e-05
Identities = 36/117 (30%), Positives = 54/117 (46%), Gaps = 14/117 (11%)
Query: 429 EKEGDYVPPEKLKLLALQRGEDPGNLNESEEEEEEDDNNEGDGDEEGENEEEEEDAEAGS 488
E + Y +K + + +Q N + SEEEEEE + E +EE E EEEEED S
Sbjct: 1414 ENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEE---EEEEEEEEEEEDENDDS 1470
Query: 489 EKEEEARLAALEEQRMEGKKPRVMAGTLKLEDKQRLAQEEESEAKRLAIMMMKKREK 545
+ + R KK R + KL + + A +EE E ++ ++REK
Sbjct: 1471 KSPGKGR-----------KKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREK 1516
Score = 38.9 bits (89), Expect = 0.013
Identities = 30/143 (20%), Positives = 57/143 (39%), Gaps = 13/143 (9%)
Query: 457 SEEEEEEDDNNEGDGDEEGENEEE-------------EEDAEAGSEKEEEARLAALEEQR 503
SE+ E+ D G +E E+E+E EE+ + +K++ R+ E+
Sbjct: 1376 SEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSS 1435
Query: 504 MEGKKPRVMAGTLKLEDKQRLAQEEESEAKRLAIMMMKKREKYLYQKIMFGKRRKIREAN 563
E K K E+++ +EEE E + + +KI+ + + N
Sbjct: 1436 SENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQN 1495
Query: 564 KLAEKRKAHDEAVRSEKKAKKAR 586
L E+ + E++ +K R
Sbjct: 1496 ALKEEEERRKRIAEREREREKLR 1518
Score = 38.5 bits (88), Expect = 0.017
Identities = 42/174 (24%), Positives = 69/174 (39%), Gaps = 25/174 (14%)
Query: 425 PFVTEKEGDYVPPEKLKLLALQRGEDPGNLNESEEEEEEDDNNEGDGDEEGENEEEEEDA 484
P + + D PE + E NL+ E+ +D+ EG +NEE D
Sbjct: 1255 PVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDE 1314
Query: 485 EAGSEKEEEARLAALEEQRMEGKKPRVMAGTLKLEDKQRLAQEEESEAKRLAIMMMKKRE 544
EA ++ E+ + E KKPR L+ K ++ E E K+ K +E
Sbjct: 1315 EAKNQVNSES-----DSDSEESKKPRYRHRLLR--HKLTVSDGESGEEKK-----TKPKE 1362
Query: 545 KYLYQKIMFGKRRKI----------REANKLAEKRKAHDEAVRSEKKAKKARPE 588
++++ RRK+ +E+ E ++ DE + AKKA E
Sbjct: 1363 ---HKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELE 1413
Score = 34.7 bits (78), Expect = 0.25
Identities = 35/174 (20%), Positives = 68/174 (39%), Gaps = 27/174 (15%)
Query: 433 DYVPPEKLKLLALQRGEDPGNLNESEEEEEEDDNNEGDGDEEGENEEEEE---------- 482
D P E K Q E+PG +EE + N+E D D E +
Sbjct: 1293 DDEPEEGKKRTGKQNEENPG-----DEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTV 1347
Query: 483 -DAEAGSEKEEEARLAALEEQRMEGKKPRVMAGTLKLED-------KQRLAQEEESEAKR 534
D E+G EK+ + + E + ++G+ R ++ + + +++ E+ + R
Sbjct: 1348 SDGESGEEKKTKPK----EHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPR 1403
Query: 535 LAIMMMKKREKYLYQKIMFGKRRKIREANKLAEKRKAHDEAVRSEKKAKKARPE 588
+ E+ KRR+I+ + + K++ E EK+ ++ E
Sbjct: 1404 TRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEE 1457
>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
9 [Homo sapiens]
Length = 771
Score = 48.1 bits (113), Expect = 2e-05
Identities = 33/88 (37%), Positives = 47/88 (53%), Gaps = 6/88 (6%)
Query: 450 DPGNLNESEEEEEEDDNNEGDGDEEGENEEEEED---AEAGSEKEEEARLAALE--EQRM 504
+ G+ +E EEEEEE++ EG EE E EEEEE+ E GS EE + +A E E+ M
Sbjct: 274 ESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEM 333
Query: 505 EGKKPRVMAGTLKLEDKQRLAQEE-ESE 531
+ R L + + R ++ ESE
Sbjct: 334 SEDEERENENHLLVVPESRFDRDSGESE 361
Score = 40.4 bits (93), Expect = 0.005
Identities = 21/87 (24%), Positives = 39/87 (44%)
Query: 457 SEEEEEEDDNNEGDGDEEGENEEEEEDAEAGSEKEEEARLAALEEQRMEGKKPRVMAGTL 516
S E ++ G +EE E EEEEE+ E EEE EE+ +
Sbjct: 266 SSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSA 325
Query: 517 KLEDKQRLAQEEESEAKRLAIMMMKKR 543
+ ++ ++++EE E + +++ + R
Sbjct: 326 EEVSEEEMSEDEERENENHLLVVPESR 352
Score = 39.7 bits (91), Expect = 0.008
Identities = 42/187 (22%), Positives = 82/187 (43%), Gaps = 21/187 (11%)
Query: 423 LSPFVTEKEGDYVPPEKLKLLALQRGEDPGNLNESEEEEEEDD--------NNEGDGDEE 474
L + EK+ EK ++ L+ +D + +S EE E D N+ ++
Sbjct: 13 LDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDS 72
Query: 475 GENEEEEEDAEAGSEKEEEARLAAL----EEQRMEGKKPRVMAGTLKLEDKQRLAQEE-- 528
E+ EE+D+ A ++ +R + +E+R E K RV + E ++R +E+
Sbjct: 73 MEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDK 132
Query: 529 -----ESEAKRLAIMMMKKREKYLYQKI--MFGKRRKIREANKLAEKRKAHDEAVRSEKK 581
E + +R +RE+ +++ + RK+RE K ++K + +K
Sbjct: 133 ARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRK 192
Query: 582 AKKARPE 588
++AR E
Sbjct: 193 EREARRE 199
Score = 36.6 bits (83), Expect = 0.066
Identities = 20/64 (31%), Positives = 27/64 (42%), Gaps = 4/64 (6%)
Query: 446 QRGEDPGNLNESEEEEEEDDNNEGDGDEEGE----NEEEEEDAEAGSEKEEEARLAALEE 501
+ G E EEEEEE++ G EE E EE+ E+E E L + E
Sbjct: 291 EEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPE 350
Query: 502 QRME 505
R +
Sbjct: 351 SRFD 354
Score = 29.6 bits (65), Expect = 8.1
Identities = 33/130 (25%), Positives = 53/130 (40%), Gaps = 18/130 (13%)
Query: 455 NESEEEEEEDDNNEGDGDEEGENEEEEEDAEAGSEKEEEARLA-ALEEQRMEGKKPRVMA 513
+E +E++ E + + E EE +A E E + R A E R E + +
Sbjct: 102 DEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLE 161
Query: 514 GTLKLEDKQRLAQEEESEAKRLAIMMMKKREKYLYQKIMFGKRRKIREANKLAEKRKAHD 573
+ E K R Q+E+ E K+RE+ + RRK REA + + AH
Sbjct: 162 RKRERERKMREQQKEQRE--------QKERERRAEE------RRKEREARR---EVSAHH 204
Query: 574 EAVRSEKKAK 583
+R + K
Sbjct: 205 RTMREDYSDK 214
>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
8 [Homo sapiens]
Length = 780
Score = 48.1 bits (113), Expect = 2e-05
Identities = 33/88 (37%), Positives = 47/88 (53%), Gaps = 6/88 (6%)
Query: 450 DPGNLNESEEEEEEDDNNEGDGDEEGENEEEEED---AEAGSEKEEEARLAALE--EQRM 504
+ G+ +E EEEEEE++ EG EE E EEEEE+ E GS EE + +A E E+ M
Sbjct: 283 ESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEM 342
Query: 505 EGKKPRVMAGTLKLEDKQRLAQEE-ESE 531
+ R L + + R ++ ESE
Sbjct: 343 SEDEERENENHLLVVPESRFDRDSGESE 370
Score = 40.4 bits (93), Expect = 0.005
Identities = 21/87 (24%), Positives = 39/87 (44%)
Query: 457 SEEEEEEDDNNEGDGDEEGENEEEEEDAEAGSEKEEEARLAALEEQRMEGKKPRVMAGTL 516
S E ++ G +EE E EEEEE+ E EEE EE+ +
Sbjct: 275 SSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSA 334
Query: 517 KLEDKQRLAQEEESEAKRLAIMMMKKR 543
+ ++ ++++EE E + +++ + R
Sbjct: 335 EEVSEEEMSEDEERENENHLLVVPESR 361
Score = 36.6 bits (83), Expect = 0.066
Identities = 20/64 (31%), Positives = 27/64 (42%), Gaps = 4/64 (6%)
Query: 446 QRGEDPGNLNESEEEEEEDDNNEGDGDEEGE----NEEEEEDAEAGSEKEEEARLAALEE 501
+ G E EEEEEE++ G EE E EE+ E+E E L + E
Sbjct: 300 EEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPE 359
Query: 502 QRME 505
R +
Sbjct: 360 SRFD 363
Score = 35.0 bits (79), Expect = 0.19
Identities = 40/185 (21%), Positives = 79/185 (42%), Gaps = 19/185 (10%)
Query: 423 LSPFVTEKEGDYVPPEKLKLLALQRGEDPGNLNESEEEEEEDD--------NNEGDGDEE 474
L + EK+ EK ++ L+ +D + +S EE E D N+ ++
Sbjct: 13 LDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDS 72
Query: 475 GENEEEEEDAEAGSEKEEEARLAAL----EEQRMEGKKPRVMAGTLKLEDKQRLAQEE-- 528
E+ EE+D+ A ++ +R + +E+R E K RV + E ++R +E+
Sbjct: 73 MEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDK 132
Query: 529 -----ESEAKRLAIMMMKKREKYLYQKIMFGKRRKIREANKLAEKRKAHDEAVRSEKKAK 583
E + +R +RE+ +F R + E + E++ + + E+K +
Sbjct: 133 ARREWERQKRREMAREHSRRERGNDGVCLFRDRLEQLERKRERERKMREQQKEQREQKER 192
Query: 584 KARPE 588
+ R E
Sbjct: 193 ERRAE 197
>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
5 [Homo sapiens]
Length = 748
Score = 48.1 bits (113), Expect = 2e-05
Identities = 33/88 (37%), Positives = 47/88 (53%), Gaps = 6/88 (6%)
Query: 450 DPGNLNESEEEEEEDDNNEGDGDEEGENEEEEED---AEAGSEKEEEARLAALE--EQRM 504
+ G+ +E EEEEEE++ EG EE E EEEEE+ E GS EE + +A E E+ M
Sbjct: 251 ESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEM 310
Query: 505 EGKKPRVMAGTLKLEDKQRLAQEE-ESE 531
+ R L + + R ++ ESE
Sbjct: 311 SEDEERENENHLLVVPESRFDRDSGESE 338
Score = 40.4 bits (93), Expect = 0.005
Identities = 21/87 (24%), Positives = 39/87 (44%)
Query: 457 SEEEEEEDDNNEGDGDEEGENEEEEEDAEAGSEKEEEARLAALEEQRMEGKKPRVMAGTL 516
S E ++ G +EE E EEEEE+ E EEE EE+ +
Sbjct: 243 SSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSA 302
Query: 517 KLEDKQRLAQEEESEAKRLAIMMMKKR 543
+ ++ ++++EE E + +++ + R
Sbjct: 303 EEVSEEEMSEDEERENENHLLVVPESR 329
Score = 36.6 bits (83), Expect = 0.066
Identities = 20/64 (31%), Positives = 27/64 (42%), Gaps = 4/64 (6%)
Query: 446 QRGEDPGNLNESEEEEEEDDNNEGDGDEEGE----NEEEEEDAEAGSEKEEEARLAALEE 501
+ G E EEEEEE++ G EE E EE+ E+E E L + E
Sbjct: 268 EEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPE 327
Query: 502 QRME 505
R +
Sbjct: 328 SRFD 331
Score = 36.2 bits (82), Expect = 0.086
Identities = 32/134 (23%), Positives = 55/134 (41%), Gaps = 25/134 (18%)
Query: 455 NESEEEEEEDDNNEGDGDEEGENEEEEEDAEAGSEKEEEARLAALEEQRMEGKKPRVMAG 514
+E +E+ ++ +G + +E+E + E EE A E +R +K R MA
Sbjct: 68 DEKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQDKARREWER---QKRREMAR 124
Query: 515 TLKLEDKQRLAQEEESEAKRLAIMMMKKREKYLYQKIMFGKRRKIREANKLAEKRKAHDE 574
++ RL Q E +KRE+ RK+RE K ++K +
Sbjct: 125 EHSRRERDRLEQLE------------RKRER----------ERKMREQQKEQREQKERER 162
Query: 575 AVRSEKKAKKARPE 588
+K ++AR E
Sbjct: 163 RAEERRKEREARRE 176
>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
4 [Homo sapiens]
Length = 737
Score = 48.1 bits (113), Expect = 2e-05
Identities = 33/88 (37%), Positives = 47/88 (53%), Gaps = 6/88 (6%)
Query: 450 DPGNLNESEEEEEEDDNNEGDGDEEGENEEEEED---AEAGSEKEEEARLAALE--EQRM 504
+ G+ +E EEEEEE++ EG EE E EEEEE+ E GS EE + +A E E+ M
Sbjct: 240 ESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEM 299
Query: 505 EGKKPRVMAGTLKLEDKQRLAQEE-ESE 531
+ R L + + R ++ ESE
Sbjct: 300 SEDEERENENHLLVVPESRFDRDSGESE 327
Score = 40.4 bits (93), Expect = 0.005
Identities = 21/87 (24%), Positives = 39/87 (44%)
Query: 457 SEEEEEEDDNNEGDGDEEGENEEEEEDAEAGSEKEEEARLAALEEQRMEGKKPRVMAGTL 516
S E ++ G +EE E EEEEE+ E EEE EE+ +
Sbjct: 232 SSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSA 291
Query: 517 KLEDKQRLAQEEESEAKRLAIMMMKKR 543
+ ++ ++++EE E + +++ + R
Sbjct: 292 EEVSEEEMSEDEERENENHLLVVPESR 318
Score = 36.6 bits (83), Expect = 0.066
Identities = 20/64 (31%), Positives = 27/64 (42%), Gaps = 4/64 (6%)
Query: 446 QRGEDPGNLNESEEEEEEDDNNEGDGDEEGE----NEEEEEDAEAGSEKEEEARLAALEE 501
+ G E EEEEEE++ G EE E EE+ E+E E L + E
Sbjct: 257 EEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPE 316
Query: 502 QRME 505
R +
Sbjct: 317 SRFD 320
Score = 33.9 bits (76), Expect = 0.43
Identities = 36/165 (21%), Positives = 73/165 (44%), Gaps = 21/165 (12%)
Query: 445 LQRGEDPGNLNESEEEEEEDD--------NNEGDGDEEGENEEEEEDAEAGSEKEEEARL 496
+ + +D + +S EE E D N+ ++ E+ EE+D+ A ++ +R
Sbjct: 1 MSQSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK 60
Query: 497 AAL----EEQRMEGKKPRVMAGTLKLEDKQRLAQEE-------ESEAKRLAIMMMKKREK 545
+ +E+R E K RV + E ++R +E+ E + +R +RE+
Sbjct: 61 EKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRER 120
Query: 546 YLYQKI--MFGKRRKIREANKLAEKRKAHDEAVRSEKKAKKARPE 588
+++ + RK+RE K ++K + +K ++AR E
Sbjct: 121 DRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARRE 165
Score = 29.6 bits (65), Expect = 8.1
Identities = 33/130 (25%), Positives = 53/130 (40%), Gaps = 18/130 (13%)
Query: 455 NESEEEEEEDDNNEGDGDEEGENEEEEEDAEAGSEKEEEARLA-ALEEQRMEGKKPRVMA 513
+E +E++ E + + E EE +A E E + R A E R E + +
Sbjct: 68 DEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLE 127
Query: 514 GTLKLEDKQRLAQEEESEAKRLAIMMMKKREKYLYQKIMFGKRRKIREANKLAEKRKAHD 573
+ E K R Q+E+ E K+RE+ + RRK REA + + AH
Sbjct: 128 RKRERERKMREQQKEQRE--------QKERERRAEE------RRKEREARR---EVSAHH 170
Query: 574 EAVRSEKKAK 583
+R + K
Sbjct: 171 RTMREDYSDK 180
>gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isoform
3 [Homo sapiens]
Length = 526
Score = 48.1 bits (113), Expect = 2e-05
Identities = 33/88 (37%), Positives = 47/88 (53%), Gaps = 6/88 (6%)
Query: 450 DPGNLNESEEEEEEDDNNEGDGDEEGENEEEEED---AEAGSEKEEEARLAALE--EQRM 504
+ G+ +E EEEEEE++ EG EE E EEEEE+ E GS EE + +A E E+ M
Sbjct: 29 ESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEM 88
Query: 505 EGKKPRVMAGTLKLEDKQRLAQEE-ESE 531
+ R L + + R ++ ESE
Sbjct: 89 SEDEERENENHLLVVPESRFDRDSGESE 116
Score = 40.4 bits (93), Expect = 0.005
Identities = 21/87 (24%), Positives = 39/87 (44%)
Query: 457 SEEEEEEDDNNEGDGDEEGENEEEEEDAEAGSEKEEEARLAALEEQRMEGKKPRVMAGTL 516
S E ++ G +EE E EEEEE+ E EEE EE+ +
Sbjct: 21 SSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSA 80
Query: 517 KLEDKQRLAQEEESEAKRLAIMMMKKR 543
+ ++ ++++EE E + +++ + R
Sbjct: 81 EEVSEEEMSEDEERENENHLLVVPESR 107
Score = 36.6 bits (83), Expect = 0.066
Identities = 20/64 (31%), Positives = 27/64 (42%), Gaps = 4/64 (6%)
Query: 446 QRGEDPGNLNESEEEEEEDDNNEGDGDEEGE----NEEEEEDAEAGSEKEEEARLAALEE 501
+ G E EEEEEE++ G EE E EE+ E+E E L + E
Sbjct: 46 EEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPE 105
Query: 502 QRME 505
R +
Sbjct: 106 SRFD 109
>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
2 [Homo sapiens]
Length = 782
Score = 48.1 bits (113), Expect = 2e-05
Identities = 33/88 (37%), Positives = 47/88 (53%), Gaps = 6/88 (6%)
Query: 450 DPGNLNESEEEEEEDDNNEGDGDEEGENEEEEED---AEAGSEKEEEARLAALE--EQRM 504
+ G+ +E EEEEEE++ EG EE E EEEEE+ E GS EE + +A E E+ M
Sbjct: 285 ESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEM 344
Query: 505 EGKKPRVMAGTLKLEDKQRLAQEE-ESE 531
+ R L + + R ++ ESE
Sbjct: 345 SEDEERENENHLLVVPESRFDRDSGESE 372
Score = 40.4 bits (93), Expect = 0.005
Identities = 21/87 (24%), Positives = 39/87 (44%)
Query: 457 SEEEEEEDDNNEGDGDEEGENEEEEEDAEAGSEKEEEARLAALEEQRMEGKKPRVMAGTL 516
S E ++ G +EE E EEEEE+ E EEE EE+ +
Sbjct: 277 SSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSA 336
Query: 517 KLEDKQRLAQEEESEAKRLAIMMMKKR 543
+ ++ ++++EE E + +++ + R
Sbjct: 337 EEVSEEEMSEDEERENENHLLVVPESR 363
Score = 36.6 bits (83), Expect = 0.066
Identities = 20/64 (31%), Positives = 27/64 (42%), Gaps = 4/64 (6%)
Query: 446 QRGEDPGNLNESEEEEEEDDNNEGDGDEEGE----NEEEEEDAEAGSEKEEEARLAALEE 501
+ G E EEEEEE++ G EE E EE+ E+E E L + E
Sbjct: 302 EEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPE 361
Query: 502 QRME 505
R +
Sbjct: 362 SRFD 365
Score = 36.2 bits (82), Expect = 0.086
Identities = 32/134 (23%), Positives = 55/134 (41%), Gaps = 25/134 (18%)
Query: 455 NESEEEEEEDDNNEGDGDEEGENEEEEEDAEAGSEKEEEARLAALEEQRMEGKKPRVMAG 514
+E +E+ ++ +G + +E+E + E EE A E +R +K R MA
Sbjct: 102 DEKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQDKARREWER---QKRREMAR 158
Query: 515 TLKLEDKQRLAQEEESEAKRLAIMMMKKREKYLYQKIMFGKRRKIREANKLAEKRKAHDE 574
++ RL Q E +KRE+ RK+RE K ++K +
Sbjct: 159 EHSRRERDRLEQLE------------RKRER----------ERKMREQQKEQREQKERER 196
Query: 575 AVRSEKKAKKARPE 588
+K ++AR E
Sbjct: 197 RAEERRKEREARRE 210
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 47.8 bits (112), Expect = 3e-05
Identities = 43/163 (26%), Positives = 82/163 (50%), Gaps = 7/163 (4%)
Query: 429 EKEGDYVPPEKLKLLA-LQRGEDPGNL-NESEEEEEEDDNNEGDGDEEGENEEEEEDAEA 486
+ E D++ E + A LQ + L N +++EE + + +E E + +E++ E
Sbjct: 264 QAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQE-EK 322
Query: 487 GSEKEEEARLAALEEQRMEGKKPRVMAGTLKLEDKQRLAQEEESEAKRLAIMMMKKREKY 546
E+EE+ R +E++M ++ + K+ ++ + E+E + +RL MM +K EK
Sbjct: 323 IREQEEKIRE---QEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKI 379
Query: 547 LYQKIMFGKRRKIRE-ANKLAEKRKAHDEAVRSEKKAKKARPE 588
+ ++ KIRE K E+ K ++ R E++AK R E
Sbjct: 380 RELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQE 422
Score = 44.7 bits (104), Expect = 2e-04
Identities = 33/150 (22%), Positives = 76/150 (50%), Gaps = 15/150 (10%)
Query: 438 EKLKLLALQRGEDPGNLNESEEEEEEDDNNEGDGDEEGENEEEEEDAEAGSEKEEEARLA 497
EK++ L E + E EE+ E + ++E + +EEE+ E +E+EA++
Sbjct: 363 EKMRRLEEMMWEKEEKIRELEEKMHEQEKIR---EQEEKRQEEEKIREQEKRQEQEAKMW 419
Query: 498 ALEE------QRMEGKKPRVMAGTLKLEDKQRLAQEEESEAKRLAIMMMKKREKYLYQKI 551
EE +++ ++ ++ K+ +++++ +EE+ + + M ++ EK Q+
Sbjct: 420 RQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQE---EMWRQEEKIREQEE 476
Query: 552 MFGKRRKIREANKLAEKRKAHDEAVRSEKK 581
++ ++ K+ E K+ RK ++ R E+K
Sbjct: 477 IWRQKEKMHEQEKI---RKQEEKVWRQEEK 503
Score = 38.1 bits (87), Expect = 0.023
Identities = 26/130 (20%), Positives = 65/130 (50%), Gaps = 3/130 (2%)
Query: 458 EEEEEEDDNNEGDGDEEGENEEEEEDAEAGSEKEEEARLAALEEQRMEGKKPRVMAGTLK 517
E+EE+ + E ++E +E+EE EK +E +E+++ ++ ++ K
Sbjct: 527 EQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEK 586
Query: 518 LEDKQRLAQEEESEAKRLAIMMMKKREK-YLYQKIMFGKRRKIREANK--LAEKRKAHDE 574
+ +++ E+E + + MM ++ EK + ++ M + K++E + ++ K ++
Sbjct: 587 IREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQ 646
Query: 575 AVRSEKKAKK 584
VR ++ +K
Sbjct: 647 EVRLRQQEEK 656
Score = 37.7 bits (86), Expect = 0.030
Identities = 35/146 (23%), Positives = 66/146 (45%), Gaps = 7/146 (4%)
Query: 446 QRGEDPGNLNESEEEEEEDDNNEGDGDEEGENEEEEEDAEAGSEKEEEARLAALEEQRM- 504
++ E L E E+EE + E E E+E+ EK E +E +M
Sbjct: 360 EKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMW 419
Query: 505 -EGKKPRVMAGTLKLEDKQRLAQEEESEAKRLAIMMMKKREKYLYQKIMFGKRRKIREAN 563
+ +K R ++ ++K+ QEE+ + +++ EK Q+ M+ + KIRE
Sbjct: 420 RQEEKIREQEEKIREQEKKMWRQEEKIHEQE----KIREEEKRQEQEEMWRQEEKIREQE 475
Query: 564 KL-AEKRKAHDEAVRSEKKAKKARPE 588
++ +K K H++ +++ K R E
Sbjct: 476 EIWRQKEKMHEQEKIRKQEEKVWRQE 501
Score = 35.0 bits (79), Expect = 0.19
Identities = 27/144 (18%), Positives = 69/144 (47%), Gaps = 6/144 (4%)
Query: 438 EKLKLLALQRGEDPGNLNESEEEEEEDDNNEGDGDEEGENEE----EEEDAEAGSEK--E 491
EK++ + E + E EE +E + G+ +E+ + +E +EE EK E
Sbjct: 523 EKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIRE 582
Query: 492 EEARLAALEEQRMEGKKPRVMAGTLKLEDKQRLAQEEESEAKRLAIMMMKKREKYLYQKI 551
++ ++ EE+ E ++ + E ++++ ++EE ++ M ++ + ++
Sbjct: 583 QKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEK 642
Query: 552 MFGKRRKIREANKLAEKRKAHDEA 575
M+ + ++R+ + ++ + H EA
Sbjct: 643 MWEQEVRLRQQEEKMQEHQEHLEA 666
Score = 33.9 bits (76), Expect = 0.43
Identities = 29/142 (20%), Positives = 66/142 (46%), Gaps = 15/142 (10%)
Query: 459 EEEEEDDNNEGDGDEEGENEEEE---------EDAEAGSEKEEEARLAAL---EEQRMEG 506
EEE+ + E EE E+EE E + ++E+ R +E+++
Sbjct: 454 EEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIRE 513
Query: 507 KKPRVMAGTLKLEDKQRLAQEEESEAKRLAIMMMKKREKYLYQKIMFGKRRKIREANKLA 566
++ ++ K+ +++ +E+E + + MM ++ EK Q+ ++ K+R +
Sbjct: 514 QEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMR---RQE 570
Query: 567 EKRKAHDEAVRSEKKAKKARPE 588
EK + +E +R +K+ + + E
Sbjct: 571 EKIREQEEKIREQKEKIREQEE 592
Score = 33.9 bits (76), Expect = 0.43
Identities = 30/138 (21%), Positives = 64/138 (46%), Gaps = 6/138 (4%)
Query: 446 QRGEDPGNLNESEEEEEEDDNNEGDGDEEGENEEEEEDAEAGSEK--EEEARLAALEEQR 503
Q E+ E E+EE + E+ + ++EE EK ++E ++ +E++
Sbjct: 459 QEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIRE-QEEK 517
Query: 504 MEGKKPRVMAGTLKLEDKQRLAQEEESEAKRLAIMMMKKREKYLYQKIMFGKRRKIREAN 563
M ++ ++ K+ +++ +E+E + M ++ EK Q+ M + KIRE
Sbjct: 518 MWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQE 577
Query: 564 KLAEKRKAHDEAVRSEKK 581
EK + E +R +++
Sbjct: 578 ---EKIREQKEKIREQEE 592
Score = 33.1 bits (74), Expect = 0.73
Identities = 26/135 (19%), Positives = 67/135 (49%), Gaps = 8/135 (5%)
Query: 454 LNESEEEEEEDDNNEGDGDEEGENEEEEEDAEAGSEKEEEARLAALEEQRMEGKKPRVMA 513
+ E EE+ E + +E+ +E+ + E E+EE R +E+++ ++ +
Sbjct: 425 IREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWR----QEEKIR-EQEEIWR 479
Query: 514 GTLKLEDKQRLAQEEESEAKRLAIMMMKKREKYLYQKIMFGKRRKIREANKLAEKRKAHD 573
K+ +++++ ++EE ++ M ++ + ++ M+ + KIRE EK + +
Sbjct: 480 QKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQE---EKIREQE 536
Query: 574 EAVRSEKKAKKARPE 588
E +R +++ + + E
Sbjct: 537 EKIREQEEMMQEQEE 551
Score = 32.3 bits (72), Expect = 1.2
Identities = 22/114 (19%), Positives = 61/114 (53%), Gaps = 3/114 (2%)
Query: 459 EEEEEDDNNEGDGDEEGENEEEEEDAEAGSEK--EEEARLAALEEQRMEGKKPRVMAGTL 516
+EE+ D E ++E + +EE EK E+E ++ EE M+ ++ ++
Sbjct: 500 QEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEM-MQEQEEKMGEQEE 558
Query: 517 KLEDKQRLAQEEESEAKRLAIMMMKKREKYLYQKIMFGKRRKIREANKLAEKRK 570
K+++++++ ++EE ++ + +K + ++ ++ + KIRE ++ ++++
Sbjct: 559 KMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQE 612
Score = 30.8 bits (68), Expect = 3.6
Identities = 32/148 (21%), Positives = 69/148 (46%), Gaps = 18/148 (12%)
Query: 449 EDPGNLNESEEE---EEEDDNNEGDGDEEGENEEEEE---DAEAGSEKEE--EARLAALE 500
E + E E++ +EE + + EE + +E+EE E E+EE + E
Sbjct: 427 EQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHE 486
Query: 501 EQRMEGKKPRVMAGTLKLEDKQRLAQEEESEAKRLAIMMMKKREKYLYQKIMFGKRRKIR 560
++++ ++ +V K+ D++ +E+E + R + ++ EK Q+ KIR
Sbjct: 487 QEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQE------EKIR 540
Query: 561 EANKL----AEKRKAHDEAVRSEKKAKK 584
E ++ EK +E ++ ++K ++
Sbjct: 541 EQEEMMQEQEEKMGEQEEKMQEQEKMRR 568
Score = 30.0 bits (66), Expect = 6.2
Identities = 22/101 (21%), Positives = 43/101 (42%)
Query: 429 EKEGDYVPPEKLKLLALQRGEDPGNLNESEEEEEEDDNNEGDGDEEGENEEEEEDAEAGS 488
E+E EK++ + E + E +E+ E + + +E+ +EE +
Sbjct: 555 EQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEK 614
Query: 489 EKEEEARLAALEEQRMEGKKPRVMAGTLKLEDKQRLAQEEE 529
E+E ++ EE+ E ++ E + RL Q+EE
Sbjct: 615 MWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEE 655
>gi|113204617 skeletal muscle ryanodine receptor isoform 2 [Homo
sapiens]
Length = 5033
Score = 47.8 bits (112), Expect = 3e-05
Identities = 25/68 (36%), Positives = 41/68 (60%), Gaps = 2/68 (2%)
Query: 457 SEEEEEEDDNNEGDGDEEGENEEEEEDAEAGSEKEEEARLAALEEQRMEGKKPRVMAGTL 516
+EEEEEED+ EG+ ++E E EE+EE+ E EE+ A E ++ EG + ++ +
Sbjct: 1872 TEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEGLL--QM 1929
Query: 517 KLEDKQRL 524
KL + +L
Sbjct: 1930 KLPESVKL 1937
Score = 45.4 bits (106), Expect = 1e-04
Identities = 24/59 (40%), Positives = 37/59 (62%), Gaps = 7/59 (11%)
Query: 450 DPGNLNESEEEEEEDDNNEGDGDEEGENEEEEEDAEAGSEKEEEARLAALEEQRMEGKK 508
+P E EEEE+E++ +G+EE E E+EE++ E EKE+E + EE+ EG+K
Sbjct: 1867 EPEVFTEEEEEEDEEE----EGEEEDEEEKEEDEEETAQEKEDEEK---EEEEAAEGEK 1918
Score = 39.7 bits (91), Expect = 0.008
Identities = 29/83 (34%), Positives = 42/83 (50%), Gaps = 10/83 (12%)
Query: 432 GDYVPPEKLKLLALQRGEDPGNLNESEEEEEEDDNNEGDGDE-----EGENEEEEEDAEA 486
GD + LK++ + + + EEE EE+D E + DE E E+EE+EE+ A
Sbjct: 1855 GDEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAA 1914
Query: 487 GSEKEEEARLAALEEQRMEGKKP 509
EKEE LEE ++ K P
Sbjct: 1915 EGEKEE-----GLEEGLLQMKLP 1932
Score = 32.3 bits (72), Expect = 1.2
Identities = 22/78 (28%), Positives = 36/78 (46%), Gaps = 13/78 (16%)
Query: 472 DEEGENEEEEEDAEAGSEKEEEARLAALEEQRMEGKKPRVMAGTLKLEDKQRLAQEEESE 531
+EE E+EEEE + E EKEE+ A E++ E ++++ A+ E+ E
Sbjct: 1874 EEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEE-------------KEEEEAAEGEKEE 1920
Query: 532 AKRLAIMMMKKREKYLYQ 549
++ MK E Q
Sbjct: 1921 GLEEGLLQMKLPESVKLQ 1938
>gi|113204615 skeletal muscle ryanodine receptor isoform 1 [Homo
sapiens]
Length = 5038
Score = 47.8 bits (112), Expect = 3e-05
Identities = 25/68 (36%), Positives = 41/68 (60%), Gaps = 2/68 (2%)
Query: 457 SEEEEEEDDNNEGDGDEEGENEEEEEDAEAGSEKEEEARLAALEEQRMEGKKPRVMAGTL 516
+EEEEEED+ EG+ ++E E EE+EE+ E EE+ A E ++ EG + ++ +
Sbjct: 1872 TEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEGLL--QM 1929
Query: 517 KLEDKQRL 524
KL + +L
Sbjct: 1930 KLPESVKL 1937
Score = 45.4 bits (106), Expect = 1e-04
Identities = 24/59 (40%), Positives = 37/59 (62%), Gaps = 7/59 (11%)
Query: 450 DPGNLNESEEEEEEDDNNEGDGDEEGENEEEEEDAEAGSEKEEEARLAALEEQRMEGKK 508
+P E EEEE+E++ +G+EE E E+EE++ E EKE+E + EE+ EG+K
Sbjct: 1867 EPEVFTEEEEEEDEEE----EGEEEDEEEKEEDEEETAQEKEDEEK---EEEEAAEGEK 1918
Score = 39.7 bits (91), Expect = 0.008
Identities = 29/83 (34%), Positives = 42/83 (50%), Gaps = 10/83 (12%)
Query: 432 GDYVPPEKLKLLALQRGEDPGNLNESEEEEEEDDNNEGDGDE-----EGENEEEEEDAEA 486
GD + LK++ + + + EEE EE+D E + DE E E+EE+EE+ A
Sbjct: 1855 GDEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAA 1914
Query: 487 GSEKEEEARLAALEEQRMEGKKP 509
EKEE LEE ++ K P
Sbjct: 1915 EGEKEE-----GLEEGLLQMKLP 1932
Score = 32.3 bits (72), Expect = 1.2
Identities = 22/78 (28%), Positives = 36/78 (46%), Gaps = 13/78 (16%)
Query: 472 DEEGENEEEEEDAEAGSEKEEEARLAALEEQRMEGKKPRVMAGTLKLEDKQRLAQEEESE 531
+EE E+EEEE + E EKEE+ A E++ E ++++ A+ E+ E
Sbjct: 1874 EEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEE-------------KEEEEAAEGEKEE 1920
Query: 532 AKRLAIMMMKKREKYLYQ 549
++ MK E Q
Sbjct: 1921 GLEEGLLQMKLPESVKLQ 1938
>gi|51477718 TATA box binding protein-associated factor, RNA
polymerase II, Q [Homo sapiens]
Length = 462
Score = 47.8 bits (112), Expect = 3e-05
Identities = 34/120 (28%), Positives = 64/120 (53%), Gaps = 7/120 (5%)
Query: 453 NLNESEEEEEEDDNNEGDGDEEGENEEEEED-AEAGSEKEEEARLAALEEQRM-EGKKPR 510
N ++ E+E++ED++ + D DE+ + EEEEED +E E++ +A + R EG
Sbjct: 331 NNDDDEDEDDEDEDEDEDEDEDEDKEEEEEDCSEEYLERQLQAEFIESGQYRANEGTSSI 390
Query: 511 VMAGTLKLEDKQRLAQEEESEAKRLAIMMMKKREKYLYQKIMFGKRRKIREANKLAEKRK 570
VM ++E K++ + +++A+R ++MK L + + E +L EK+K
Sbjct: 391 VMEIQKQIEKKEKKLHKIQNKAQRQKDLIMKVENLTLKNHF-----QSVLEQLELQEKQK 445
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.134 0.384
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,717,240
Number of Sequences: 37866
Number of extensions: 1129277
Number of successful extensions: 31829
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 632
Number of HSP's successfully gapped in prelim test: 571
Number of HSP's that attempted gapping in prelim test: 10601
Number of HSP's gapped (non-prelim): 9358
length of query: 588
length of database: 18,247,518
effective HSP length: 108
effective length of query: 480
effective length of database: 14,157,990
effective search space: 6795835200
effective search space used: 6795835200
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.