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Search of human proteins with 75709228
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens]
(409 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens] 835 0.0
gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens] 835 0.0
gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens] 835 0.0
gi|133908623 protein kinase C, iota [Homo sapiens] 628 e-180
gi|4885563 protein kinase C, epsilon [Homo sapiens] 374 e-104
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] 367 e-101
gi|4506067 protein kinase C, alpha [Homo sapiens] 364 e-101
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens] 362 e-100
gi|28557781 protein kinase C, eta [Homo sapiens] 356 2e-98
gi|13384594 protein kinase C, gamma [Homo sapiens] 344 7e-95
gi|4502023 AKT2 kinase [Homo sapiens] 312 3e-85
gi|47157325 protein kinase C, delta [Homo sapiens] 310 2e-84
gi|31377782 protein kinase C, delta [Homo sapiens] 310 2e-84
gi|5453976 protein kinase C, theta [Homo sapiens] 307 1e-83
gi|62241015 AKT1 kinase [Homo sapiens] 300 1e-81
gi|62241013 AKT1 kinase [Homo sapiens] 300 1e-81
gi|62241011 AKT1 kinase [Homo sapiens] 300 1e-81
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 300 2e-81
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 298 8e-81
gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alph... 295 4e-80
gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta... 295 4e-80
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H... 289 4e-78
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [... 289 4e-78
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [... 289 4e-78
gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [... 289 4e-78
gi|5453974 protein kinase N2 [Homo sapiens] 288 5e-78
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 288 8e-78
gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 288 8e-78
gi|47132591 protein kinase N1 isoform 1 [Homo sapiens] 270 2e-72
gi|47132589 protein kinase N1 isoform 2 [Homo sapiens] 270 2e-72
>gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens]
Length = 409
Score = 835 bits (2157), Expect = 0.0
Identities = 409/409 (100%), Positives = 409/409 (100%)
Query: 1 MDSVMPSQEPPVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKI 60
MDSVMPSQEPPVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKI
Sbjct: 1 MDSVMPSQEPPVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKI 60
Query: 61 SQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHV 120
SQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHV
Sbjct: 61 SQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHV 120
Query: 121 FEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIA 180
FEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIA
Sbjct: 121 FEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIA 180
Query: 181 LNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEIL 240
LNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEIL
Sbjct: 181 LNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEIL 240
Query: 241 RGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSV 300
RGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSV
Sbjct: 241 RGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSV 300
Query: 301 KASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDY 360
KASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDY
Sbjct: 301 KASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDY 360
Query: 361 GLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV 409
GLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV
Sbjct: 361 GLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV 409
>gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens]
Length = 409
Score = 835 bits (2157), Expect = 0.0
Identities = 409/409 (100%), Positives = 409/409 (100%)
Query: 1 MDSVMPSQEPPVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKI 60
MDSVMPSQEPPVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKI
Sbjct: 1 MDSVMPSQEPPVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKI 60
Query: 61 SQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHV 120
SQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHV
Sbjct: 61 SQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHV 120
Query: 121 FEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIA 180
FEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIA
Sbjct: 121 FEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIA 180
Query: 181 LNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEIL 240
LNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEIL
Sbjct: 181 LNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEIL 240
Query: 241 RGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSV 300
RGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSV
Sbjct: 241 RGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSV 300
Query: 301 KASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDY 360
KASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDY
Sbjct: 301 KASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDY 360
Query: 361 GLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV 409
GLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV
Sbjct: 361 GLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV 409
>gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens]
Length = 592
Score = 835 bits (2157), Expect = 0.0
Identities = 409/409 (100%), Positives = 409/409 (100%)
Query: 1 MDSVMPSQEPPVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKI 60
MDSVMPSQEPPVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKI
Sbjct: 184 MDSVMPSQEPPVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKI 243
Query: 61 SQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHV 120
SQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHV
Sbjct: 244 SQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHV 303
Query: 121 FEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIA 180
FEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIA
Sbjct: 304 FEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIA 363
Query: 181 LNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEIL 240
LNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEIL
Sbjct: 364 LNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEIL 423
Query: 241 RGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSV 300
RGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSV
Sbjct: 424 RGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSV 483
Query: 301 KASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDY 360
KASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDY
Sbjct: 484 KASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDY 543
Query: 361 GLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV 409
GLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV
Sbjct: 544 GLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV 592
>gi|133908623 protein kinase C, iota [Homo sapiens]
Length = 596
Score = 628 bits (1620), Expect = e-180
Identities = 310/406 (76%), Positives = 352/406 (86%), Gaps = 10/406 (2%)
Query: 8 QEP--PVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKISQGLG 65
QEP P+D + +D I Y SS H+S+ E+ K ++ + K S LG
Sbjct: 197 QEPVMPMDQSSMHSD---HAQTVIPYNPSS--HESLDQVGEE-KEAMNTRESGKASSSLG 250
Query: 66 LQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQAS 125
LQDFDL+RVIGRGSYAKVLLVRLKK D+IYAMKVVKKELV+DDEDIDWVQTEKHVFEQAS
Sbjct: 251 LQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQAS 310
Query: 126 SNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLH 185
++PFLVGLHSCFQT SRLF VIEYVNGGDLMFHMQRQRKLPEEHARFY+AEI +ALN+LH
Sbjct: 311 NHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLH 370
Query: 186 ERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEY 245
ERGIIYRDLKLDNVLLD++GHIKLTDYGMCKEGL PGDTTSTFCGTPNYIAPEILRGE+Y
Sbjct: 371 ERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDY 430
Query: 246 GFSVDWWALGVLMFEMMAGRSPFDII--TDNPDMNTEDYLFQVILEKPIRIPRFLSVKAS 303
GFSVDWWALGVLMFEMMAGRSPFDI+ +DNPD NTEDYLFQVILEK IRIPR LSVKA+
Sbjct: 431 GFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAA 490
Query: 304 HVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLD 363
VLK FLNKDPKERLGC PQTGF+DI+ H FFR++DWD++E+KQ +PPF+P I+ ++GLD
Sbjct: 491 SVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLD 550
Query: 364 NFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV 409
NFD+QFT+EPVQLTPDD+D +++IDQSEFEGFEYINPLL+S EE V
Sbjct: 551 NFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLLMSAEECV 596
>gi|4885563 protein kinase C, epsilon [Homo sapiens]
Length = 737
Score = 374 bits (960), Expect = e-104
Identities = 186/341 (54%), Positives = 242/341 (70%), Gaps = 8/341 (2%)
Query: 64 LGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQ 123
LGL +F+ I+V+G+GS+ KV+L LK D++YA+KV+KK+++ D+D+D TEK +
Sbjct: 403 LGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILAL 462
Query: 124 ASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNF 183
A +P+L L+ CFQT RLF V+EYVNGGDLMF +QR RK E +RFYAAE+ AL F
Sbjct: 463 ARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMF 522
Query: 184 LHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGE 243
LH+ G+IYRDLKLDN+LLDA+GH KL D+GMCKEG+ G TT+TFCGTP+YIAPEIL+
Sbjct: 523 LHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQEL 582
Query: 244 EYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKAS 303
EYG SVDWWALGVLM+EMMAG+ PF+ DN ED LF+ IL + P +LS +A
Sbjct: 583 EYGPSVDWWALGVLMYEMMAGQPPFE--ADN-----EDDLFESILHDDVLYPVWLSKEAV 635
Query: 304 HVLKGFLNKDPKERLGC-RPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGL 362
+LK F+ K+P +RLGC Q G IK H FF+ IDW LLE+K+ PPF+P+I +
Sbjct: 636 SILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDV 695
Query: 363 DNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLL 403
+NFD FT E LT DE +K+I+Q EF+GF Y L+
Sbjct: 696 NNFDQDFTREEPVLTLVDEAIVKQINQEEFKGFSYFGEDLM 736
>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
Length = 671
Score = 367 bits (941), Expect = e-101
Identities = 175/335 (52%), Positives = 234/335 (69%), Gaps = 8/335 (2%)
Query: 66 LQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQAS 125
L DF+ + V+G+GS+ KV+L K D++YA+K++KK++V D+D++ EK V
Sbjct: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398
Query: 126 SNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLH 185
PFL LHSCFQT RL+ V+EYVNGGDLM+H+Q+ + E HA FYAAEI I L FL
Sbjct: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQ 458
Query: 186 ERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEY 245
+GIIYRDLKLDNV+LD++GHIK+ D+GMCKE + G TT TFCGTP+YIAPEI+ + Y
Sbjct: 459 SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY 518
Query: 246 GFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHV 305
G SVDWWA GVL++EM+AG++PF + ED LFQ I+E + P+ +S +A +
Sbjct: 519 GKSVDWWAFGVLLYEMLAGQAPF-------EGEDEDELFQSIMEHNVAYPKSMSKEAVAI 571
Query: 306 LKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNF 365
KG + K P +RLGC P+ G DIK HAFFR IDW+ LE+K+ PP++P+ D NF
Sbjct: 572 CKGLMTKHPGKRLGCGPE-GERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNF 630
Query: 366 DTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINP 400
D +FT +PV+LTP D+ I +DQ+EF GF Y NP
Sbjct: 631 DKEFTRQPVELTPTDKLFIMNLDQNEFAGFSYTNP 665
>gi|4506067 protein kinase C, alpha [Homo sapiens]
Length = 672
Score = 364 bits (935), Expect = e-101
Identities = 181/356 (50%), Positives = 242/356 (67%), Gaps = 15/356 (4%)
Query: 45 SEDLKPVIDGMDGIKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKEL 104
SED K + +D +K++ DF+ + V+G+GS+ KV+L K +++YA+K++KK++
Sbjct: 321 SEDRKQPSNNLDRVKLT------DFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDV 374
Query: 105 VHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRK 164
V D+D++ EK V PFL LHSCFQT RL+ V+EYVNGGDLM+H+Q+ K
Sbjct: 375 VIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGK 434
Query: 165 LPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDT 224
E A FYAAEI I L FLH+RGIIYRDLKLDNV+LD++GHIK+ D+GMCKE + G T
Sbjct: 435 FKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVT 494
Query: 225 TSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLF 284
T TFCGTP+YIAPEI+ + YG SVDWWA GVL++EM+AG+ PF D ED LF
Sbjct: 495 TRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPF-------DGEDEDELF 547
Query: 285 QVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLE 344
Q I+E + P+ LS +A + KG + K P +RLGC P+ G D++ HAFFR IDW+ LE
Sbjct: 548 QSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPE-GERDVREHAFFRRIDWEKLE 606
Query: 345 KKQALPPFQPQITDDYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINP 400
++ PPF+P++ G +NFD FT LTP D+ I IDQS+FEGF Y+NP
Sbjct: 607 NREIQPPFKPKVCGK-GAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVNP 661
>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
Length = 673
Score = 362 bits (929), Expect = e-100
Identities = 176/341 (51%), Positives = 235/341 (68%), Gaps = 9/341 (2%)
Query: 66 LQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQAS 125
L DF+ + V+G+GS+ KV+L K D++YA+K++KK++V D+D++ EK V
Sbjct: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398
Query: 126 SNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLH 185
PFL LHSCFQT RL+ V+EYVNGGDLM+H+Q+ + E HA FYAAEI I L FL
Sbjct: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQ 458
Query: 186 ERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEY 245
+GIIYRDLKLDNV+LD++GHIK+ D+GMCKE + G TT TFCGTP+YIAPEI+ + Y
Sbjct: 459 SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY 518
Query: 246 GFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHV 305
G SVDWWA GVL++EM+AG++PF + ED LFQ I+E + P+ +S +A +
Sbjct: 519 GKSVDWWAFGVLLYEMLAGQAPF-------EGEDEDELFQSIMEHNVAYPKSMSKEAVAI 571
Query: 306 LKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNF 365
KG + K P +RLGC P+ G DIK HAFFR IDW+ LE+K+ PP++P+ +NF
Sbjct: 572 CKGLMTKHPGKRLGCGPE-GERDIKEHAFFRYIDWEKLERKEIQPPYKPKAC-GRNAENF 629
Query: 366 DTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTE 406
D FT P LTP D++ I+ IDQSEFEGF ++N L E
Sbjct: 630 DRFFTRHPPVLTPPDQEVIRNIDQSEFEGFSFVNSEFLKPE 670
>gi|28557781 protein kinase C, eta [Homo sapiens]
Length = 683
Score = 356 bits (913), Expect = 2e-98
Identities = 174/346 (50%), Positives = 232/346 (67%), Gaps = 7/346 (2%)
Query: 57 GIKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQT 116
G+ S LG+ +F+ IRV+G+GS+ KV+L R+K+ +YA+KV+KK+++ D+D++ T
Sbjct: 343 GVNSSNRLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMT 402
Query: 117 EKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAE 176
EK + A ++PFL L CFQT RLF V+E+VNGGDLMFH+Q+ R+ E ARFYAAE
Sbjct: 403 EKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAE 462
Query: 177 ICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIA 236
I AL FLH++GIIYRDLKLDNVLLD +GH KL D+GMCKEG+ G TT+TFCGTP+YIA
Sbjct: 463 IISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIA 522
Query: 237 PEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPR 296
PEIL+ YG +VDWWA+GVL++EM+ G +PF + ED LF+ IL + P
Sbjct: 523 PEILQEMLYGPAVDWWAMGVLLYEMLCGHAPF-------EAENEDDLFEAILNDEVVYPT 575
Query: 297 FLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQI 356
+L A+ +LK F+ K+P RLG Q G I H FF+ IDW L +Q PPF+P+I
Sbjct: 576 WLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRI 635
Query: 357 TDDYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLL 402
+ NFD F E LTP DE + I+Q EF F Y++P L
Sbjct: 636 KSREDVSNFDPDFIKEEPVLTPIDEGHLPMINQDEFRNFSYVSPEL 681
>gi|13384594 protein kinase C, gamma [Homo sapiens]
Length = 697
Score = 344 bits (883), Expect = 7e-95
Identities = 172/342 (50%), Positives = 230/342 (67%), Gaps = 14/342 (4%)
Query: 64 LGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQ 123
L + DF + V+G+GS+ KV+L + +D++YA+K++KK+++ D+D+D EK V
Sbjct: 346 LHISDFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLAL 405
Query: 124 ASSNP-----FLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEIC 178
P FL LHS FQT RL+ V+EYV GGDLM+H+Q+ K E HA FYAAEI
Sbjct: 406 GGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEIA 465
Query: 179 IALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPE 238
I L FLH +GIIYRDLKLDNV+LDA+GHIK+TD+GMCKE + PG TT TFCGTP+YIAPE
Sbjct: 466 IGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAPE 525
Query: 239 ILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFL 298
I+ + YG SVDWW+ GVL++EM+AG+ PF D E+ LFQ I+E+ + P+ L
Sbjct: 526 IIAYQPYGKSVDWWSFGVLLYEMLAGQPPF-------DGEDEEELFQAIMEQTVTYPKSL 578
Query: 299 SVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITD 358
S +A + KGFL K P +RLG P G I++H FFR IDW+ LE+ + PPF+P+
Sbjct: 579 SREAVAICKGFLTKHPGKRLGSGPD-GEPTIRAHGFFRWIDWERLERLEIPPPFRPRPCG 637
Query: 359 DYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINP 400
G +NFD FT LTP D + IDQ++F+GF Y+NP
Sbjct: 638 RSG-ENFDKFFTRAAPALTPPDRLVLASIDQADFQGFTYVNP 678
>gi|4502023 AKT2 kinase [Homo sapiens]
Length = 481
Score = 312 bits (800), Expect = 3e-85
Identities = 154/336 (45%), Positives = 222/336 (66%), Gaps = 13/336 (3%)
Query: 66 LQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQAS 125
+ DFD ++++G+G++ KV+LVR K + YAMK+++KE++ +++ TE V Q +
Sbjct: 149 MNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVL-QNT 207
Query: 126 SNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLH 185
+PFL L FQT RL V+EY NGG+L FH+ R+R EE ARFY AEI AL +LH
Sbjct: 208 RHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLH 267
Query: 186 ERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEY 245
R ++YRD+KL+N++LD DGHIK+TD+G+CKEG+ G T TFCGTP Y+APE+L +Y
Sbjct: 268 SRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDY 327
Query: 246 GFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHV 305
G +VDWW LGV+M+EMM GR PF N D + LF++IL + IR PR LS +A +
Sbjct: 328 GRAVDWWGLGVVMYEMMCGRLPF----YNQD---HERLFELILMEEIRFPRTLSPEAKSL 380
Query: 306 LKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNF 365
L G L KDPK+RLG P ++ H FF SI+W + +K+ LPPF+PQ+T + F
Sbjct: 381 LAGLLKKDPKQRLGGGPSDA-KEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYF 439
Query: 366 DTQFTSEPVQLTPDDE-DAIKRID---QSEFEGFEY 397
D +FT++ + +TP D D++ ++ ++ F F Y
Sbjct: 440 DDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSY 475
>gi|47157325 protein kinase C, delta [Homo sapiens]
Length = 676
Score = 310 bits (793), Expect = 2e-84
Identities = 156/340 (45%), Positives = 221/340 (65%), Gaps = 12/340 (3%)
Query: 61 SQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHV 120
S + +F +V+G+GS+ KVLL LK + +A+K +KK++V D+D++ EK V
Sbjct: 341 SSKCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRV 400
Query: 121 FEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIA 180
A+ NPFL L FQT LF V+E++NGGDLM+H+Q + + A FYAAEI
Sbjct: 401 LTLAAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCG 460
Query: 181 LNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEIL 240
L FLH +GIIYRDLKLDNVLLD DGHIK+ D+GMCKE + STFCGTP+YIAPEIL
Sbjct: 461 LQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEIL 520
Query: 241 RGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSV 300
+G +Y FSVDWW+ GVL++EM+ G+SPF + ED LF+ I PR+++
Sbjct: 521 QGLKYTFSVDWWSFGVLLYEMLIGQSPF-------HGDDEDELFESIRVDTPHYPRWITK 573
Query: 301 KASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDY 360
++ +L+ ++P +RLG TG +IK H FF++I+W LLEK++ PPF+P++
Sbjct: 574 ESKDILEKLFEREPTKRLGV---TG--NIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPR 628
Query: 361 GLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINP 400
NFD +F +E +L+ D++ I +DQS F GF ++NP
Sbjct: 629 DYSNFDQEFLNEKARLSYSDKNLIDSMDQSAFAGFSFVNP 668
>gi|31377782 protein kinase C, delta [Homo sapiens]
Length = 676
Score = 310 bits (793), Expect = 2e-84
Identities = 156/340 (45%), Positives = 221/340 (65%), Gaps = 12/340 (3%)
Query: 61 SQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHV 120
S + +F +V+G+GS+ KVLL LK + +A+K +KK++V D+D++ EK V
Sbjct: 341 SSKCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRV 400
Query: 121 FEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIA 180
A+ NPFL L FQT LF V+E++NGGDLM+H+Q + + A FYAAEI
Sbjct: 401 LTLAAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCG 460
Query: 181 LNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEIL 240
L FLH +GIIYRDLKLDNVLLD DGHIK+ D+GMCKE + STFCGTP+YIAPEIL
Sbjct: 461 LQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEIL 520
Query: 241 RGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSV 300
+G +Y FSVDWW+ GVL++EM+ G+SPF + ED LF+ I PR+++
Sbjct: 521 QGLKYTFSVDWWSFGVLLYEMLIGQSPF-------HGDDEDELFESIRVDTPHYPRWITK 573
Query: 301 KASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDY 360
++ +L+ ++P +RLG TG +IK H FF++I+W LLEK++ PPF+P++
Sbjct: 574 ESKDILEKLFEREPTKRLGV---TG--NIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPR 628
Query: 361 GLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINP 400
NFD +F +E +L+ D++ I +DQS F GF ++NP
Sbjct: 629 DYSNFDQEFLNEKARLSYSDKNLIDSMDQSAFAGFSFVNP 668
>gi|5453976 protein kinase C, theta [Homo sapiens]
Length = 706
Score = 307 bits (786), Expect = 1e-83
Identities = 149/337 (44%), Positives = 216/337 (64%), Gaps = 12/337 (3%)
Query: 64 LGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQ 123
L ++DF L +++G+GS+ KV L KK +Q +A+K +KK++V D+D++ EK V
Sbjct: 375 LKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSL 434
Query: 124 ASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNF 183
A +PFL + FQT LF V+EY+NGGDLM+H+Q K A FYAAEI + L F
Sbjct: 435 AWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQF 494
Query: 184 LHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGE 243
LH +GI+YRDLKLDN+LLD DGHIK+ D+GMCKE + T+TFCGTP+YIAPEIL G+
Sbjct: 495 LHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQ 554
Query: 244 EYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKAS 303
+Y SVDWW+ GVL++EM+ G+SPF + E+ + ++ P PR+L +A
Sbjct: 555 KYNHSVDWWSFGVLLYEMLIGQSPFH------GQDEEELFHSIRMDNPF-YPRWLEKEAK 607
Query: 304 HVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLD 363
+L ++P++RLG R DI+ H FR I+W+ LE+K+ PPF+P++ +
Sbjct: 608 DLLVKLFVREPEKRLGVR-----GDIRQHPLFREINWEELERKEIDPPFRPKVKSPFDCS 662
Query: 364 NFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINP 400
NFD +F +E +L+ D I +DQ+ F F ++NP
Sbjct: 663 NFDKEFLNEKPRLSFADRALINSMDQNMFRNFSFMNP 699
>gi|62241015 AKT1 kinase [Homo sapiens]
Length = 480
Score = 300 bits (769), Expect = 1e-81
Identities = 152/337 (45%), Positives = 217/337 (64%), Gaps = 14/337 (4%)
Query: 66 LQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQAS 125
+ +F+ ++++G+G++ KV+LV+ K + YAMK++KKE++ +++ TE V Q S
Sbjct: 147 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL-QNS 205
Query: 126 SNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLH 185
+PFL L FQT RL V+EY NGG+L FH+ R+R E+ ARFY AEI AL++LH
Sbjct: 206 RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLH 265
Query: 186 -ERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEE 244
E+ ++YRDLKL+N++LD DGHIK+TD+G+CKEG+ G T TFCGTP Y+APE+L +
Sbjct: 266 SEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND 325
Query: 245 YGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASH 304
YG +VDWW LGV+M+EMM GR PF N D + LF++IL + IR PR L +A
Sbjct: 326 YGRAVDWWGLGVVMYEMMCGRLPF----YNQD---HEKLFELILMEEIRFPRTLGPEAKS 378
Query: 305 VLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDN 364
+L G L KDPK+RLG + +I H FF I W + +K+ PPF+PQ+T +
Sbjct: 379 LLSGLLKKDPKQRLGGGSEDA-KEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRY 437
Query: 365 FDTQFTSEPVQLTPDDEDAIKRIDQSE----FEGFEY 397
FD +FT++ + +TP D+D SE F F Y
Sbjct: 438 FDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSY 474
>gi|62241013 AKT1 kinase [Homo sapiens]
Length = 480
Score = 300 bits (769), Expect = 1e-81
Identities = 152/337 (45%), Positives = 217/337 (64%), Gaps = 14/337 (4%)
Query: 66 LQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQAS 125
+ +F+ ++++G+G++ KV+LV+ K + YAMK++KKE++ +++ TE V Q S
Sbjct: 147 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL-QNS 205
Query: 126 SNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLH 185
+PFL L FQT RL V+EY NGG+L FH+ R+R E+ ARFY AEI AL++LH
Sbjct: 206 RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLH 265
Query: 186 -ERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEE 244
E+ ++YRDLKL+N++LD DGHIK+TD+G+CKEG+ G T TFCGTP Y+APE+L +
Sbjct: 266 SEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND 325
Query: 245 YGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASH 304
YG +VDWW LGV+M+EMM GR PF N D + LF++IL + IR PR L +A
Sbjct: 326 YGRAVDWWGLGVVMYEMMCGRLPF----YNQD---HEKLFELILMEEIRFPRTLGPEAKS 378
Query: 305 VLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDN 364
+L G L KDPK+RLG + +I H FF I W + +K+ PPF+PQ+T +
Sbjct: 379 LLSGLLKKDPKQRLGGGSEDA-KEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRY 437
Query: 365 FDTQFTSEPVQLTPDDEDAIKRIDQSE----FEGFEY 397
FD +FT++ + +TP D+D SE F F Y
Sbjct: 438 FDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSY 474
>gi|62241011 AKT1 kinase [Homo sapiens]
Length = 480
Score = 300 bits (769), Expect = 1e-81
Identities = 152/337 (45%), Positives = 217/337 (64%), Gaps = 14/337 (4%)
Query: 66 LQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQAS 125
+ +F+ ++++G+G++ KV+LV+ K + YAMK++KKE++ +++ TE V Q S
Sbjct: 147 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL-QNS 205
Query: 126 SNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLH 185
+PFL L FQT RL V+EY NGG+L FH+ R+R E+ ARFY AEI AL++LH
Sbjct: 206 RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLH 265
Query: 186 -ERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEE 244
E+ ++YRDLKL+N++LD DGHIK+TD+G+CKEG+ G T TFCGTP Y+APE+L +
Sbjct: 266 SEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND 325
Query: 245 YGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASH 304
YG +VDWW LGV+M+EMM GR PF N D + LF++IL + IR PR L +A
Sbjct: 326 YGRAVDWWGLGVVMYEMMCGRLPF----YNQD---HEKLFELILMEEIRFPRTLGPEAKS 378
Query: 305 VLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDN 364
+L G L KDPK+RLG + +I H FF I W + +K+ PPF+PQ+T +
Sbjct: 379 LLSGLLKKDPKQRLGGGSEDA-KEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRY 437
Query: 365 FDTQFTSEPVQLTPDDEDAIKRIDQSE----FEGFEY 397
FD +FT++ + +TP D+D SE F F Y
Sbjct: 438 FDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSY 474
>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
Length = 479
Score = 300 bits (768), Expect = 2e-81
Identities = 151/338 (44%), Positives = 218/338 (64%), Gaps = 15/338 (4%)
Query: 66 LQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQAS 125
+ DFD ++++G+G++ KV+LVR K + + YAMK++KKE++ +++ TE V + +
Sbjct: 145 MNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKN-T 203
Query: 126 SNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLH 185
+PFL L FQT RL V+EYVNGG+L FH+ R+R E+ RFY AEI AL++LH
Sbjct: 204 RHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLH 263
Query: 186 ERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEY 245
I+YRDLKL+N++LD DGHIK+TD+G+CKEG+ T TFCGTP Y+APE+L +Y
Sbjct: 264 SGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDY 323
Query: 246 GFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHV 305
G +VDWW LGV+M+EMM GR PF N D + LF++IL + I+ PR LS A +
Sbjct: 324 GRAVDWWGLGVVMYEMMCGRLPF----YNQD---HEKLFELILMEDIKFPRTLSSDAKSL 376
Query: 306 LKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNF 365
L G L KDP +RLG P +I H+FF ++W + K+ +PPF+PQ+T + F
Sbjct: 377 LSGLLIKDPNKRLGGGPDDA-KEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYF 435
Query: 366 DTQFTSEPVQLTPD---DEDAIKRID---QSEFEGFEY 397
D +FT++ + +TP DED + +D + F F Y
Sbjct: 436 DEEFTAQTITITPPEKYDEDGMDCMDNERRPHFPQFSY 473
>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
Length = 465
Score = 298 bits (762), Expect = 8e-81
Identities = 144/316 (45%), Positives = 210/316 (66%), Gaps = 9/316 (2%)
Query: 66 LQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQAS 125
+ DFD ++++G+G++ KV+LVR K + + YAMK++KKE++ +++ TE V + +
Sbjct: 145 MNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKN-T 203
Query: 126 SNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLH 185
+PFL L FQT RL V+EYVNGG+L FH+ R+R E+ RFY AEI AL++LH
Sbjct: 204 RHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLH 263
Query: 186 ERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEY 245
I+YRDLKL+N++LD DGHIK+TD+G+CKEG+ T TFCGTP Y+APE+L +Y
Sbjct: 264 SGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDY 323
Query: 246 GFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHV 305
G +VDWW LGV+M+EMM GR PF N D + LF++IL + I+ PR LS A +
Sbjct: 324 GRAVDWWGLGVVMYEMMCGRLPF----YNQD---HEKLFELILMEDIKFPRTLSSDAKSL 376
Query: 306 LKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNF 365
L G L KDP +RLG P +I H+FF ++W + K+ +PPF+PQ+T + F
Sbjct: 377 LSGLLIKDPNKRLGGGPDDA-KEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYF 435
Query: 366 DTQFTSEPVQLTPDDE 381
D +FT++ + +TP ++
Sbjct: 436 DEEFTAQTITITPPEK 451
>gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alpha
[Homo sapiens]
Length = 367
Score = 295 bits (756), Expect = 4e-80
Identities = 151/334 (45%), Positives = 215/334 (64%), Gaps = 14/334 (4%)
Query: 68 DFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSN 127
DFD ++VIG+G+Y KVLL + K + YA+KV++K+ + ++ + E+ V + +
Sbjct: 34 DFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRH 93
Query: 128 PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHER 187
PFLVGL FQT +L+ V++YVNGG+L FH+QR+R+ E ARFYAAE+ A+ +LH
Sbjct: 94 PFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSL 153
Query: 188 GIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGF 247
IIYRDLK +N+LLD GH+ LTD+G+CKEG+ P DTTSTFCGTP Y+APE+LR E Y
Sbjct: 154 NIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDR 213
Query: 248 SVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLK 307
+VDWW LG +++EM+ G PF + D++ +++ IL +P++IP +V A +L+
Sbjct: 214 AVDWWCLGAVLYEMLHGLPPF----YSQDVS---QMYENILHQPLQIPGGRTVAACDLLQ 266
Query: 308 GFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDT 367
L+KD ++RLG + F +IK+H FF I+WD L K+ PPF P +T L +FD
Sbjct: 267 SLLHKDQRQRLGSK--ADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDP 324
Query: 368 QFTSEPVQ----LTPDDEDAIKRIDQSEFEGFEY 397
+FT E V TPD A S F GF Y
Sbjct: 325 EFTQEAVSKSIGCTPDTV-ASSSGASSAFLGFSY 357
>gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta
[Homo sapiens]
Length = 427
Score = 295 bits (756), Expect = 4e-80
Identities = 151/334 (45%), Positives = 215/334 (64%), Gaps = 14/334 (4%)
Query: 68 DFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSN 127
DFD ++VIG+G+Y KVLL + K + YA+KV++K+ + ++ + E+ V + +
Sbjct: 94 DFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRH 153
Query: 128 PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHER 187
PFLVGL FQT +L+ V++YVNGG+L FH+QR+R+ E ARFYAAE+ A+ +LH
Sbjct: 154 PFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSL 213
Query: 188 GIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGF 247
IIYRDLK +N+LLD GH+ LTD+G+CKEG+ P DTTSTFCGTP Y+APE+LR E Y
Sbjct: 214 NIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDR 273
Query: 248 SVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLK 307
+VDWW LG +++EM+ G PF + D++ +++ IL +P++IP +V A +L+
Sbjct: 274 AVDWWCLGAVLYEMLHGLPPF----YSQDVS---QMYENILHQPLQIPGGRTVAACDLLQ 326
Query: 308 GFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDT 367
L+KD ++RLG + F +IK+H FF I+WD L K+ PPF P +T L +FD
Sbjct: 327 SLLHKDQRQRLGSK--ADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDP 384
Query: 368 QFTSEPVQ----LTPDDEDAIKRIDQSEFEGFEY 397
+FT E V TPD A S F GF Y
Sbjct: 385 EFTQEAVSKSIGCTPDTV-ASSSGASSAFLGFSY 417
>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
sapiens]
Length = 431
Score = 289 bits (739), Expect = 4e-78
Identities = 147/339 (43%), Positives = 213/339 (62%), Gaps = 15/339 (4%)
Query: 68 DFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSN 127
DF ++VIG+GS+ KVLL R K + YA+KV++K+ + ++ + +E++V + +
Sbjct: 97 DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKH 156
Query: 128 PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHER 187
PFLVGLH FQT +L+ V++Y+NGG+L +H+QR+R E ARFYAAEI AL +LH
Sbjct: 157 PFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSL 216
Query: 188 GIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGF 247
I+YRDLK +N+LLD+ GHI LTD+G+CKE + TTSTFCGTP Y+APE+L + Y
Sbjct: 217 NIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDR 276
Query: 248 SVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLK 307
+VDWW LG +++EM+ G PF NT + ++ IL KP+++ ++ A H+L+
Sbjct: 277 TVDWWCLGAVLYEMLYGLPPF------YSRNTAE-MYDNILNKPLQLKPNITNSARHLLE 329
Query: 308 GFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDT 367
G L KD +RLG + F +IKSH FF I+WD L K+ PPF P ++ L +FD
Sbjct: 330 GLLQKDRTKRLGAKDD--FMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDP 387
Query: 368 QFTSEPVQ----LTPDDEDAIKRIDQS--EFEGFEYINP 400
+FT EPV +PD + ++ F GF Y P
Sbjct: 388 EFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPP 426
>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
[Homo sapiens]
Length = 445
Score = 289 bits (739), Expect = 4e-78
Identities = 147/339 (43%), Positives = 213/339 (62%), Gaps = 15/339 (4%)
Query: 68 DFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSN 127
DF ++VIG+GS+ KVLL R K + YA+KV++K+ + ++ + +E++V + +
Sbjct: 111 DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKH 170
Query: 128 PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHER 187
PFLVGLH FQT +L+ V++Y+NGG+L +H+QR+R E ARFYAAEI AL +LH
Sbjct: 171 PFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSL 230
Query: 188 GIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGF 247
I+YRDLK +N+LLD+ GHI LTD+G+CKE + TTSTFCGTP Y+APE+L + Y
Sbjct: 231 NIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDR 290
Query: 248 SVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLK 307
+VDWW LG +++EM+ G PF NT + ++ IL KP+++ ++ A H+L+
Sbjct: 291 TVDWWCLGAVLYEMLYGLPPF------YSRNTAE-MYDNILNKPLQLKPNITNSARHLLE 343
Query: 308 GFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDT 367
G L KD +RLG + F +IKSH FF I+WD L K+ PPF P ++ L +FD
Sbjct: 344 GLLQKDRTKRLGAKDD--FMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDP 401
Query: 368 QFTSEPVQ----LTPDDEDAIKRIDQS--EFEGFEYINP 400
+FT EPV +PD + ++ F GF Y P
Sbjct: 402 EFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPP 440
>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
[Homo sapiens]
Length = 459
Score = 289 bits (739), Expect = 4e-78
Identities = 147/339 (43%), Positives = 213/339 (62%), Gaps = 15/339 (4%)
Query: 68 DFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSN 127
DF ++VIG+GS+ KVLL R K + YA+KV++K+ + ++ + +E++V + +
Sbjct: 125 DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKH 184
Query: 128 PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHER 187
PFLVGLH FQT +L+ V++Y+NGG+L +H+QR+R E ARFYAAEI AL +LH
Sbjct: 185 PFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSL 244
Query: 188 GIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGF 247
I+YRDLK +N+LLD+ GHI LTD+G+CKE + TTSTFCGTP Y+APE+L + Y
Sbjct: 245 NIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDR 304
Query: 248 SVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLK 307
+VDWW LG +++EM+ G PF NT + ++ IL KP+++ ++ A H+L+
Sbjct: 305 TVDWWCLGAVLYEMLYGLPPF------YSRNTAE-MYDNILNKPLQLKPNITNSARHLLE 357
Query: 308 GFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDT 367
G L KD +RLG + F +IKSH FF I+WD L K+ PPF P ++ L +FD
Sbjct: 358 GLLQKDRTKRLGAKDD--FMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDP 415
Query: 368 QFTSEPVQ----LTPDDEDAIKRIDQS--EFEGFEYINP 400
+FT EPV +PD + ++ F GF Y P
Sbjct: 416 EFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPP 454
>gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2
[Homo sapiens]
Length = 526
Score = 289 bits (739), Expect = 4e-78
Identities = 147/339 (43%), Positives = 213/339 (62%), Gaps = 15/339 (4%)
Query: 68 DFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSN 127
DF ++VIG+GS+ KVLL R K + YA+KV++K+ + ++ + +E++V + +
Sbjct: 192 DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKH 251
Query: 128 PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHER 187
PFLVGLH FQT +L+ V++Y+NGG+L +H+QR+R E ARFYAAEI AL +LH
Sbjct: 252 PFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSL 311
Query: 188 GIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGF 247
I+YRDLK +N+LLD+ GHI LTD+G+CKE + TTSTFCGTP Y+APE+L + Y
Sbjct: 312 NIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDR 371
Query: 248 SVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLK 307
+VDWW LG +++EM+ G PF NT + ++ IL KP+++ ++ A H+L+
Sbjct: 372 TVDWWCLGAVLYEMLYGLPPF------YSRNTAE-MYDNILNKPLQLKPNITNSARHLLE 424
Query: 308 GFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDT 367
G L KD +RLG + F +IKSH FF I+WD L K+ PPF P ++ L +FD
Sbjct: 425 GLLQKDRTKRLGAKDD--FMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDP 482
Query: 368 QFTSEPVQ----LTPDDEDAIKRIDQS--EFEGFEYINP 400
+FT EPV +PD + ++ F GF Y P
Sbjct: 483 EFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPP 521
>gi|5453974 protein kinase N2 [Homo sapiens]
Length = 984
Score = 288 bits (738), Expect = 5e-78
Identities = 160/394 (40%), Positives = 228/394 (57%), Gaps = 25/394 (6%)
Query: 20 DLPSEETDGIAYISSSRKHDSIKDDSEDLKPVI--DGMDGIKISQ----------GLGLQ 67
D+P ++++ + I + R K SE KP G++ I + LQ
Sbjct: 597 DIPGQDSETVFDIQNDRNSILPKSQSE-YKPDTPQSGLEYSGIQELEDRRSQQRFQFNLQ 655
Query: 68 DFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASS- 126
DF V+GRG + KVLL K ++++A+K +KK + +++D + EK +FE +S
Sbjct: 656 DFRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSV 715
Query: 127 -NPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLH 185
+PFLV L +CFQT + V+EY GGDLM H+ E A FYAA + + L +LH
Sbjct: 716 RHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTD-VFSEPRAVFYAACVVLGLQYLH 774
Query: 186 ERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEY 245
E I+YRDLKLDN+LLD +G +K+ D+G+CKEG+G GD TSTFCGTP ++APE+L Y
Sbjct: 775 EHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSY 834
Query: 246 GFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHV 305
+VDWW LGVL++EM+ G SPF + E+ +F I+ +R PRFLS +A +
Sbjct: 835 TRAVDWWGLGVLIYEMLVGESPF-------PGDDEEEVFDSIVNDEVRYPRFLSTEAISI 887
Query: 306 LKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNF 365
++ L ++P+ RLG + D+K H FFR IDW L K+ PPF P I + NF
Sbjct: 888 MRRLLRRNPERRLGASEKDA-EDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNF 946
Query: 366 DTQFTSEPVQLTPDDEDAIKRIDQSE-FEGFEYI 398
D +FTSE LTP E I ++ E F F+YI
Sbjct: 947 DDEFTSEAPILTPPREPRILSEEEQEMFRDFDYI 980
>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 288 bits (736), Expect = 8e-78
Identities = 147/339 (43%), Positives = 215/339 (63%), Gaps = 15/339 (4%)
Query: 68 DFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSN 127
DFD ++VIG+GS+ KVLL + K + + YA+KV++K++V + ++ + E++V + +
Sbjct: 161 DFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKH 220
Query: 128 PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHER 187
PFLVGLH FQTT +L+ V+++VNGG+L FH+QR+R PE ARFYAAEI AL +LH
Sbjct: 221 PFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSI 280
Query: 188 GIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGF 247
I+YRDLK +N+LLD+ GH+ LTD+G+CKEG+ DTT+TFCGTP Y+APE++R + Y
Sbjct: 281 KIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDN 340
Query: 248 SVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLK 307
+VDWW LG +++EM+ G PF D +M + IL KP+ + +S+ A +L+
Sbjct: 341 TVDWWCLGAVLYEMLYGLPPF-YCRDVAEM------YDNILHKPLSLRPGVSLTAWSILE 393
Query: 308 GFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDT 367
L KD + RLG + F +I++H FF S+ W L +K+ PPF P + + NFDT
Sbjct: 394 ELLEKDRQNRLGAKED--FLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDT 451
Query: 368 QFTSE--PVQLTPDDEDAIKRIDQSE----FEGFEYINP 400
FT E P + + +I E F GF Y P
Sbjct: 452 AFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPP 490
>gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 288 bits (736), Expect = 8e-78
Identities = 147/339 (43%), Positives = 215/339 (63%), Gaps = 15/339 (4%)
Query: 68 DFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSN 127
DFD ++VIG+GS+ KVLL + K + + YA+KV++K++V + ++ + E++V + +
Sbjct: 161 DFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKH 220
Query: 128 PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHER 187
PFLVGLH FQTT +L+ V+++VNGG+L FH+QR+R PE ARFYAAEI AL +LH
Sbjct: 221 PFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSI 280
Query: 188 GIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGF 247
I+YRDLK +N+LLD+ GH+ LTD+G+CKEG+ DTT+TFCGTP Y+APE++R + Y
Sbjct: 281 KIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDN 340
Query: 248 SVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLK 307
+VDWW LG +++EM+ G PF D +M + IL KP+ + +S+ A +L+
Sbjct: 341 TVDWWCLGAVLYEMLYGLPPF-YCRDVAEM------YDNILHKPLSLRPGVSLTAWSILE 393
Query: 308 GFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDT 367
L KD + RLG + F +I++H FF S+ W L +K+ PPF P + + NFDT
Sbjct: 394 ELLEKDRQNRLGAKED--FLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDT 451
Query: 368 QFTSE--PVQLTPDDEDAIKRIDQSE----FEGFEYINP 400
FT E P + + +I E F GF Y P
Sbjct: 452 AFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPP 490
>gi|47132591 protein kinase N1 isoform 1 [Homo sapiens]
Length = 948
Score = 270 bits (689), Expect = 2e-72
Identities = 135/338 (39%), Positives = 206/338 (60%), Gaps = 12/338 (3%)
Query: 64 LGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQ 123
L L+DF + V+GRG + KVLL + + +++A+K +KK + ++++ + EK +
Sbjct: 616 LTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAA 675
Query: 124 ASS--NPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIAL 181
+S +PFLV L CFQT + V+EY GGDLM H+ E A FY+A + + L
Sbjct: 676 VTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSD-VFSEPRAIFYSACVVLGL 734
Query: 182 NFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILR 241
FLHE I+YRDLKLDN+LLD +G++K+ D+G+CKEG+G GD TSTFCGTP ++APE+L
Sbjct: 735 QFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLT 794
Query: 242 GEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVK 301
Y +VDWW LGVL++EM+ G SPF + E+ +F I+ +R PRFLS +
Sbjct: 795 DTSYTRAVDWWGLGVLLYEMLVGESPF-------PGDDEEEVFDSIVNDEVRYPRFLSAE 847
Query: 302 ASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYG 361
A +++ L ++P+ RLG + D+K FFR++ W+ L ++ PPF P ++
Sbjct: 848 AIGIMRRLLRRNPERRLGSSERDA-EDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTD 906
Query: 362 LDNFDTQFTSE-PVQLTPDDEDAIKRIDQSEFEGFEYI 398
+ NFD +FT E P P D + +Q+ F F+++
Sbjct: 907 VSNFDEEFTGEAPTLSPPRDARPLTAAEQAAFLDFDFV 944
>gi|47132589 protein kinase N1 isoform 2 [Homo sapiens]
Length = 942
Score = 270 bits (689), Expect = 2e-72
Identities = 135/338 (39%), Positives = 206/338 (60%), Gaps = 12/338 (3%)
Query: 64 LGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQ 123
L L+DF + V+GRG + KVLL + + +++A+K +KK + ++++ + EK +
Sbjct: 610 LTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAA 669
Query: 124 ASS--NPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIAL 181
+S +PFLV L CFQT + V+EY GGDLM H+ E A FY+A + + L
Sbjct: 670 VTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSD-VFSEPRAIFYSACVVLGL 728
Query: 182 NFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILR 241
FLHE I+YRDLKLDN+LLD +G++K+ D+G+CKEG+G GD TSTFCGTP ++APE+L
Sbjct: 729 QFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLT 788
Query: 242 GEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVK 301
Y +VDWW LGVL++EM+ G SPF + E+ +F I+ +R PRFLS +
Sbjct: 789 DTSYTRAVDWWGLGVLLYEMLVGESPF-------PGDDEEEVFDSIVNDEVRYPRFLSAE 841
Query: 302 ASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYG 361
A +++ L ++P+ RLG + D+K FFR++ W+ L ++ PPF P ++
Sbjct: 842 AIGIMRRLLRRNPERRLGSSERDA-EDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTD 900
Query: 362 LDNFDTQFTSE-PVQLTPDDEDAIKRIDQSEFEGFEYI 398
+ NFD +FT E P P D + +Q+ F F+++
Sbjct: 901 VSNFDEEFTGEAPTLSPPRDARPLTAAEQAAFLDFDFV 938
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.139 0.416
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,325,729
Number of Sequences: 37866
Number of extensions: 759810
Number of successful extensions: 3767
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 690
Number of HSP's successfully gapped in prelim test: 106
Number of HSP's that attempted gapping in prelim test: 1607
Number of HSP's gapped (non-prelim): 946
length of query: 409
length of database: 18,247,518
effective HSP length: 105
effective length of query: 304
effective length of database: 14,271,588
effective search space: 4338562752
effective search space used: 4338562752
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.