Guide to the Human Genome
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Search of human proteins with 75709226

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens]
         (409 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens]           835   0.0  
gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens]           835   0.0  
gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens]           835   0.0  
gi|133908623 protein kinase C, iota [Homo sapiens]                    628   e-180
gi|4885563 protein kinase C, epsilon [Homo sapiens]                   374   e-104
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]           367   e-101
gi|4506067 protein kinase C, alpha [Homo sapiens]                     364   e-101
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]           362   e-100
gi|28557781 protein kinase C, eta [Homo sapiens]                      356   2e-98
gi|13384594 protein kinase C, gamma [Homo sapiens]                    344   7e-95
gi|4502023 AKT2 kinase [Homo sapiens]                                 312   3e-85
gi|47157325 protein kinase C, delta [Homo sapiens]                    310   2e-84
gi|31377782 protein kinase C, delta [Homo sapiens]                    310   2e-84
gi|5453976 protein kinase C, theta [Homo sapiens]                     307   1e-83
gi|62241015 AKT1 kinase [Homo sapiens]                                300   1e-81
gi|62241013 AKT1 kinase [Homo sapiens]                                300   1e-81
gi|62241011 AKT1 kinase [Homo sapiens]                                300   1e-81
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]                       300   2e-81
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]                      298   8e-81
gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alph...   295   4e-80
gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta...   295   4e-80
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H...   289   4e-78
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [...   289   4e-78
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [...   289   4e-78
gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [...   289   4e-78
gi|5453974 protein kinase N2 [Homo sapiens]                           288   5e-78
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H...   288   8e-78
gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H...   288   8e-78
gi|47132591 protein kinase N1 isoform 1 [Homo sapiens]                270   2e-72
gi|47132589 protein kinase N1 isoform 2 [Homo sapiens]                270   2e-72

>gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens]
          Length = 409

 Score =  835 bits (2157), Expect = 0.0
 Identities = 409/409 (100%), Positives = 409/409 (100%)

Query: 1   MDSVMPSQEPPVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKI 60
           MDSVMPSQEPPVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKI
Sbjct: 1   MDSVMPSQEPPVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKI 60

Query: 61  SQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHV 120
           SQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHV
Sbjct: 61  SQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHV 120

Query: 121 FEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIA 180
           FEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIA
Sbjct: 121 FEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIA 180

Query: 181 LNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEIL 240
           LNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEIL
Sbjct: 181 LNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEIL 240

Query: 241 RGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSV 300
           RGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSV
Sbjct: 241 RGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSV 300

Query: 301 KASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDY 360
           KASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDY
Sbjct: 301 KASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDY 360

Query: 361 GLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV 409
           GLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV
Sbjct: 361 GLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV 409


>gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens]
          Length = 409

 Score =  835 bits (2157), Expect = 0.0
 Identities = 409/409 (100%), Positives = 409/409 (100%)

Query: 1   MDSVMPSQEPPVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKI 60
           MDSVMPSQEPPVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKI
Sbjct: 1   MDSVMPSQEPPVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKI 60

Query: 61  SQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHV 120
           SQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHV
Sbjct: 61  SQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHV 120

Query: 121 FEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIA 180
           FEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIA
Sbjct: 121 FEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIA 180

Query: 181 LNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEIL 240
           LNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEIL
Sbjct: 181 LNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEIL 240

Query: 241 RGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSV 300
           RGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSV
Sbjct: 241 RGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSV 300

Query: 301 KASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDY 360
           KASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDY
Sbjct: 301 KASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDY 360

Query: 361 GLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV 409
           GLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV
Sbjct: 361 GLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV 409


>gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens]
          Length = 592

 Score =  835 bits (2157), Expect = 0.0
 Identities = 409/409 (100%), Positives = 409/409 (100%)

Query: 1   MDSVMPSQEPPVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKI 60
           MDSVMPSQEPPVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKI
Sbjct: 184 MDSVMPSQEPPVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKI 243

Query: 61  SQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHV 120
           SQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHV
Sbjct: 244 SQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHV 303

Query: 121 FEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIA 180
           FEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIA
Sbjct: 304 FEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIA 363

Query: 181 LNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEIL 240
           LNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEIL
Sbjct: 364 LNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEIL 423

Query: 241 RGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSV 300
           RGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSV
Sbjct: 424 RGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSV 483

Query: 301 KASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDY 360
           KASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDY
Sbjct: 484 KASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDY 543

Query: 361 GLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV 409
           GLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV
Sbjct: 544 GLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV 592


>gi|133908623 protein kinase C, iota [Homo sapiens]
          Length = 596

 Score =  628 bits (1620), Expect = e-180
 Identities = 310/406 (76%), Positives = 352/406 (86%), Gaps = 10/406 (2%)

Query: 8   QEP--PVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKISQGLG 65
           QEP  P+D  +  +D        I Y  SS  H+S+    E+ K  ++  +  K S  LG
Sbjct: 197 QEPVMPMDQSSMHSD---HAQTVIPYNPSS--HESLDQVGEE-KEAMNTRESGKASSSLG 250

Query: 66  LQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQAS 125
           LQDFDL+RVIGRGSYAKVLLVRLKK D+IYAMKVVKKELV+DDEDIDWVQTEKHVFEQAS
Sbjct: 251 LQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQAS 310

Query: 126 SNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLH 185
           ++PFLVGLHSCFQT SRLF VIEYVNGGDLMFHMQRQRKLPEEHARFY+AEI +ALN+LH
Sbjct: 311 NHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLH 370

Query: 186 ERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEY 245
           ERGIIYRDLKLDNVLLD++GHIKLTDYGMCKEGL PGDTTSTFCGTPNYIAPEILRGE+Y
Sbjct: 371 ERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDY 430

Query: 246 GFSVDWWALGVLMFEMMAGRSPFDII--TDNPDMNTEDYLFQVILEKPIRIPRFLSVKAS 303
           GFSVDWWALGVLMFEMMAGRSPFDI+  +DNPD NTEDYLFQVILEK IRIPR LSVKA+
Sbjct: 431 GFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAA 490

Query: 304 HVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLD 363
            VLK FLNKDPKERLGC PQTGF+DI+ H FFR++DWD++E+KQ +PPF+P I+ ++GLD
Sbjct: 491 SVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLD 550

Query: 364 NFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV 409
           NFD+QFT+EPVQLTPDD+D +++IDQSEFEGFEYINPLL+S EE V
Sbjct: 551 NFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLLMSAEECV 596


>gi|4885563 protein kinase C, epsilon [Homo sapiens]
          Length = 737

 Score =  374 bits (960), Expect = e-104
 Identities = 186/341 (54%), Positives = 242/341 (70%), Gaps = 8/341 (2%)

Query: 64  LGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQ 123
           LGL +F+ I+V+G+GS+ KV+L  LK  D++YA+KV+KK+++  D+D+D   TEK +   
Sbjct: 403 LGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILAL 462

Query: 124 ASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNF 183
           A  +P+L  L+ CFQT  RLF V+EYVNGGDLMF +QR RK  E  +RFYAAE+  AL F
Sbjct: 463 ARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMF 522

Query: 184 LHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGE 243
           LH+ G+IYRDLKLDN+LLDA+GH KL D+GMCKEG+  G TT+TFCGTP+YIAPEIL+  
Sbjct: 523 LHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQEL 582

Query: 244 EYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKAS 303
           EYG SVDWWALGVLM+EMMAG+ PF+   DN     ED LF+ IL   +  P +LS +A 
Sbjct: 583 EYGPSVDWWALGVLMYEMMAGQPPFE--ADN-----EDDLFESILHDDVLYPVWLSKEAV 635

Query: 304 HVLKGFLNKDPKERLGC-RPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGL 362
            +LK F+ K+P +RLGC   Q G   IK H FF+ IDW LLE+K+  PPF+P+I     +
Sbjct: 636 SILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDV 695

Query: 363 DNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLL 403
           +NFD  FT E   LT  DE  +K+I+Q EF+GF Y    L+
Sbjct: 696 NNFDQDFTREEPVLTLVDEAIVKQINQEEFKGFSYFGEDLM 736


>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
          Length = 671

 Score =  367 bits (941), Expect = e-101
 Identities = 175/335 (52%), Positives = 234/335 (69%), Gaps = 8/335 (2%)

Query: 66  LQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQAS 125
           L DF+ + V+G+GS+ KV+L   K  D++YA+K++KK++V  D+D++    EK V     
Sbjct: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398

Query: 126 SNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLH 185
             PFL  LHSCFQT  RL+ V+EYVNGGDLM+H+Q+  +  E HA FYAAEI I L FL 
Sbjct: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQ 458

Query: 186 ERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEY 245
            +GIIYRDLKLDNV+LD++GHIK+ D+GMCKE +  G TT TFCGTP+YIAPEI+  + Y
Sbjct: 459 SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY 518

Query: 246 GFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHV 305
           G SVDWWA GVL++EM+AG++PF       +   ED LFQ I+E  +  P+ +S +A  +
Sbjct: 519 GKSVDWWAFGVLLYEMLAGQAPF-------EGEDEDELFQSIMEHNVAYPKSMSKEAVAI 571

Query: 306 LKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNF 365
            KG + K P +RLGC P+ G  DIK HAFFR IDW+ LE+K+  PP++P+  D     NF
Sbjct: 572 CKGLMTKHPGKRLGCGPE-GERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNF 630

Query: 366 DTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINP 400
           D +FT +PV+LTP D+  I  +DQ+EF GF Y NP
Sbjct: 631 DKEFTRQPVELTPTDKLFIMNLDQNEFAGFSYTNP 665


>gi|4506067 protein kinase C, alpha [Homo sapiens]
          Length = 672

 Score =  364 bits (935), Expect = e-101
 Identities = 181/356 (50%), Positives = 242/356 (67%), Gaps = 15/356 (4%)

Query: 45  SEDLKPVIDGMDGIKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKEL 104
           SED K   + +D +K++      DF+ + V+G+GS+ KV+L   K  +++YA+K++KK++
Sbjct: 321 SEDRKQPSNNLDRVKLT------DFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDV 374

Query: 105 VHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRK 164
           V  D+D++    EK V       PFL  LHSCFQT  RL+ V+EYVNGGDLM+H+Q+  K
Sbjct: 375 VIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGK 434

Query: 165 LPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDT 224
             E  A FYAAEI I L FLH+RGIIYRDLKLDNV+LD++GHIK+ D+GMCKE +  G T
Sbjct: 435 FKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVT 494

Query: 225 TSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLF 284
           T TFCGTP+YIAPEI+  + YG SVDWWA GVL++EM+AG+ PF       D   ED LF
Sbjct: 495 TRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPF-------DGEDEDELF 547

Query: 285 QVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLE 344
           Q I+E  +  P+ LS +A  + KG + K P +RLGC P+ G  D++ HAFFR IDW+ LE
Sbjct: 548 QSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPE-GERDVREHAFFRRIDWEKLE 606

Query: 345 KKQALPPFQPQITDDYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINP 400
            ++  PPF+P++    G +NFD  FT     LTP D+  I  IDQS+FEGF Y+NP
Sbjct: 607 NREIQPPFKPKVCGK-GAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVNP 661


>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
          Length = 673

 Score =  362 bits (929), Expect = e-100
 Identities = 176/341 (51%), Positives = 235/341 (68%), Gaps = 9/341 (2%)

Query: 66  LQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQAS 125
           L DF+ + V+G+GS+ KV+L   K  D++YA+K++KK++V  D+D++    EK V     
Sbjct: 339 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 398

Query: 126 SNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLH 185
             PFL  LHSCFQT  RL+ V+EYVNGGDLM+H+Q+  +  E HA FYAAEI I L FL 
Sbjct: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQ 458

Query: 186 ERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEY 245
            +GIIYRDLKLDNV+LD++GHIK+ D+GMCKE +  G TT TFCGTP+YIAPEI+  + Y
Sbjct: 459 SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY 518

Query: 246 GFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHV 305
           G SVDWWA GVL++EM+AG++PF       +   ED LFQ I+E  +  P+ +S +A  +
Sbjct: 519 GKSVDWWAFGVLLYEMLAGQAPF-------EGEDEDELFQSIMEHNVAYPKSMSKEAVAI 571

Query: 306 LKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNF 365
            KG + K P +RLGC P+ G  DIK HAFFR IDW+ LE+K+  PP++P+       +NF
Sbjct: 572 CKGLMTKHPGKRLGCGPE-GERDIKEHAFFRYIDWEKLERKEIQPPYKPKAC-GRNAENF 629

Query: 366 DTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTE 406
           D  FT  P  LTP D++ I+ IDQSEFEGF ++N   L  E
Sbjct: 630 DRFFTRHPPVLTPPDQEVIRNIDQSEFEGFSFVNSEFLKPE 670


>gi|28557781 protein kinase C, eta [Homo sapiens]
          Length = 683

 Score =  356 bits (913), Expect = 2e-98
 Identities = 174/346 (50%), Positives = 232/346 (67%), Gaps = 7/346 (2%)

Query: 57  GIKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQT 116
           G+  S  LG+ +F+ IRV+G+GS+ KV+L R+K+   +YA+KV+KK+++  D+D++   T
Sbjct: 343 GVNSSNRLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMT 402

Query: 117 EKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAE 176
           EK +   A ++PFL  L  CFQT  RLF V+E+VNGGDLMFH+Q+ R+  E  ARFYAAE
Sbjct: 403 EKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAE 462

Query: 177 ICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIA 236
           I  AL FLH++GIIYRDLKLDNVLLD +GH KL D+GMCKEG+  G TT+TFCGTP+YIA
Sbjct: 463 IISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIA 522

Query: 237 PEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPR 296
           PEIL+   YG +VDWWA+GVL++EM+ G +PF       +   ED LF+ IL   +  P 
Sbjct: 523 PEILQEMLYGPAVDWWAMGVLLYEMLCGHAPF-------EAENEDDLFEAILNDEVVYPT 575

Query: 297 FLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQI 356
           +L   A+ +LK F+ K+P  RLG   Q G   I  H FF+ IDW  L  +Q  PPF+P+I
Sbjct: 576 WLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRI 635

Query: 357 TDDYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLL 402
                + NFD  F  E   LTP DE  +  I+Q EF  F Y++P L
Sbjct: 636 KSREDVSNFDPDFIKEEPVLTPIDEGHLPMINQDEFRNFSYVSPEL 681


>gi|13384594 protein kinase C, gamma [Homo sapiens]
          Length = 697

 Score =  344 bits (883), Expect = 7e-95
 Identities = 172/342 (50%), Positives = 230/342 (67%), Gaps = 14/342 (4%)

Query: 64  LGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQ 123
           L + DF  + V+G+GS+ KV+L   + +D++YA+K++KK+++  D+D+D    EK V   
Sbjct: 346 LHISDFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLAL 405

Query: 124 ASSNP-----FLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEIC 178
               P     FL  LHS FQT  RL+ V+EYV GGDLM+H+Q+  K  E HA FYAAEI 
Sbjct: 406 GGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEIA 465

Query: 179 IALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPE 238
           I L FLH +GIIYRDLKLDNV+LDA+GHIK+TD+GMCKE + PG TT TFCGTP+YIAPE
Sbjct: 466 IGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAPE 525

Query: 239 ILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFL 298
           I+  + YG SVDWW+ GVL++EM+AG+ PF       D   E+ LFQ I+E+ +  P+ L
Sbjct: 526 IIAYQPYGKSVDWWSFGVLLYEMLAGQPPF-------DGEDEEELFQAIMEQTVTYPKSL 578

Query: 299 SVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITD 358
           S +A  + KGFL K P +RLG  P  G   I++H FFR IDW+ LE+ +  PPF+P+   
Sbjct: 579 SREAVAICKGFLTKHPGKRLGSGPD-GEPTIRAHGFFRWIDWERLERLEIPPPFRPRPCG 637

Query: 359 DYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINP 400
             G +NFD  FT     LTP D   +  IDQ++F+GF Y+NP
Sbjct: 638 RSG-ENFDKFFTRAAPALTPPDRLVLASIDQADFQGFTYVNP 678


>gi|4502023 AKT2 kinase [Homo sapiens]
          Length = 481

 Score =  312 bits (800), Expect = 3e-85
 Identities = 154/336 (45%), Positives = 222/336 (66%), Gaps = 13/336 (3%)

Query: 66  LQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQAS 125
           + DFD ++++G+G++ KV+LVR K   + YAMK+++KE++   +++    TE  V  Q +
Sbjct: 149 MNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVL-QNT 207

Query: 126 SNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLH 185
            +PFL  L   FQT  RL  V+EY NGG+L FH+ R+R   EE ARFY AEI  AL +LH
Sbjct: 208 RHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLH 267

Query: 186 ERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEY 245
            R ++YRD+KL+N++LD DGHIK+TD+G+CKEG+  G T  TFCGTP Y+APE+L   +Y
Sbjct: 268 SRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDY 327

Query: 246 GFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHV 305
           G +VDWW LGV+M+EMM GR PF     N D    + LF++IL + IR PR LS +A  +
Sbjct: 328 GRAVDWWGLGVVMYEMMCGRLPF----YNQD---HERLFELILMEEIRFPRTLSPEAKSL 380

Query: 306 LKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNF 365
           L G L KDPK+RLG  P     ++  H FF SI+W  + +K+ LPPF+PQ+T +     F
Sbjct: 381 LAGLLKKDPKQRLGGGPSDA-KEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYF 439

Query: 366 DTQFTSEPVQLTPDDE-DAIKRID---QSEFEGFEY 397
           D +FT++ + +TP D  D++  ++   ++ F  F Y
Sbjct: 440 DDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSY 475


>gi|47157325 protein kinase C, delta [Homo sapiens]
          Length = 676

 Score =  310 bits (793), Expect = 2e-84
 Identities = 156/340 (45%), Positives = 221/340 (65%), Gaps = 12/340 (3%)

Query: 61  SQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHV 120
           S    + +F   +V+G+GS+ KVLL  LK   + +A+K +KK++V  D+D++    EK V
Sbjct: 341 SSKCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRV 400

Query: 121 FEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIA 180
              A+ NPFL  L   FQT   LF V+E++NGGDLM+H+Q + +     A FYAAEI   
Sbjct: 401 LTLAAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCG 460

Query: 181 LNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEIL 240
           L FLH +GIIYRDLKLDNVLLD DGHIK+ D+GMCKE +      STFCGTP+YIAPEIL
Sbjct: 461 LQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEIL 520

Query: 241 RGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSV 300
           +G +Y FSVDWW+ GVL++EM+ G+SPF         + ED LF+ I       PR+++ 
Sbjct: 521 QGLKYTFSVDWWSFGVLLYEMLIGQSPF-------HGDDEDELFESIRVDTPHYPRWITK 573

Query: 301 KASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDY 360
           ++  +L+    ++P +RLG    TG  +IK H FF++I+W LLEK++  PPF+P++    
Sbjct: 574 ESKDILEKLFEREPTKRLGV---TG--NIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPR 628

Query: 361 GLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINP 400
              NFD +F +E  +L+  D++ I  +DQS F GF ++NP
Sbjct: 629 DYSNFDQEFLNEKARLSYSDKNLIDSMDQSAFAGFSFVNP 668


>gi|31377782 protein kinase C, delta [Homo sapiens]
          Length = 676

 Score =  310 bits (793), Expect = 2e-84
 Identities = 156/340 (45%), Positives = 221/340 (65%), Gaps = 12/340 (3%)

Query: 61  SQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHV 120
           S    + +F   +V+G+GS+ KVLL  LK   + +A+K +KK++V  D+D++    EK V
Sbjct: 341 SSKCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRV 400

Query: 121 FEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIA 180
              A+ NPFL  L   FQT   LF V+E++NGGDLM+H+Q + +     A FYAAEI   
Sbjct: 401 LTLAAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCG 460

Query: 181 LNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEIL 240
           L FLH +GIIYRDLKLDNVLLD DGHIK+ D+GMCKE +      STFCGTP+YIAPEIL
Sbjct: 461 LQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEIL 520

Query: 241 RGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSV 300
           +G +Y FSVDWW+ GVL++EM+ G+SPF         + ED LF+ I       PR+++ 
Sbjct: 521 QGLKYTFSVDWWSFGVLLYEMLIGQSPF-------HGDDEDELFESIRVDTPHYPRWITK 573

Query: 301 KASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDY 360
           ++  +L+    ++P +RLG    TG  +IK H FF++I+W LLEK++  PPF+P++    
Sbjct: 574 ESKDILEKLFEREPTKRLGV---TG--NIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPR 628

Query: 361 GLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINP 400
              NFD +F +E  +L+  D++ I  +DQS F GF ++NP
Sbjct: 629 DYSNFDQEFLNEKARLSYSDKNLIDSMDQSAFAGFSFVNP 668


>gi|5453976 protein kinase C, theta [Homo sapiens]
          Length = 706

 Score =  307 bits (786), Expect = 1e-83
 Identities = 149/337 (44%), Positives = 216/337 (64%), Gaps = 12/337 (3%)

Query: 64  LGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQ 123
           L ++DF L +++G+GS+ KV L   KK +Q +A+K +KK++V  D+D++    EK V   
Sbjct: 375 LKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSL 434

Query: 124 ASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNF 183
           A  +PFL  +   FQT   LF V+EY+NGGDLM+H+Q   K     A FYAAEI + L F
Sbjct: 435 AWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQF 494

Query: 184 LHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGE 243
           LH +GI+YRDLKLDN+LLD DGHIK+ D+GMCKE +     T+TFCGTP+YIAPEIL G+
Sbjct: 495 LHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQ 554

Query: 244 EYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKAS 303
           +Y  SVDWW+ GVL++EM+ G+SPF         + E+    + ++ P   PR+L  +A 
Sbjct: 555 KYNHSVDWWSFGVLLYEMLIGQSPFH------GQDEEELFHSIRMDNPF-YPRWLEKEAK 607

Query: 304 HVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLD 363
            +L     ++P++RLG R      DI+ H  FR I+W+ LE+K+  PPF+P++   +   
Sbjct: 608 DLLVKLFVREPEKRLGVR-----GDIRQHPLFREINWEELERKEIDPPFRPKVKSPFDCS 662

Query: 364 NFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINP 400
           NFD +F +E  +L+  D   I  +DQ+ F  F ++NP
Sbjct: 663 NFDKEFLNEKPRLSFADRALINSMDQNMFRNFSFMNP 699


>gi|62241015 AKT1 kinase [Homo sapiens]
          Length = 480

 Score =  300 bits (769), Expect = 1e-81
 Identities = 152/337 (45%), Positives = 217/337 (64%), Gaps = 14/337 (4%)

Query: 66  LQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQAS 125
           + +F+ ++++G+G++ KV+LV+ K   + YAMK++KKE++   +++    TE  V  Q S
Sbjct: 147 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL-QNS 205

Query: 126 SNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLH 185
            +PFL  L   FQT  RL  V+EY NGG+L FH+ R+R   E+ ARFY AEI  AL++LH
Sbjct: 206 RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLH 265

Query: 186 -ERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEE 244
            E+ ++YRDLKL+N++LD DGHIK+TD+G+CKEG+  G T  TFCGTP Y+APE+L   +
Sbjct: 266 SEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND 325

Query: 245 YGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASH 304
           YG +VDWW LGV+M+EMM GR PF     N D    + LF++IL + IR PR L  +A  
Sbjct: 326 YGRAVDWWGLGVVMYEMMCGRLPF----YNQD---HEKLFELILMEEIRFPRTLGPEAKS 378

Query: 305 VLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDN 364
           +L G L KDPK+RLG   +    +I  H FF  I W  + +K+  PPF+PQ+T +     
Sbjct: 379 LLSGLLKKDPKQRLGGGSEDA-KEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRY 437

Query: 365 FDTQFTSEPVQLTPDDEDAIKRIDQSE----FEGFEY 397
           FD +FT++ + +TP D+D       SE    F  F Y
Sbjct: 438 FDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSY 474


>gi|62241013 AKT1 kinase [Homo sapiens]
          Length = 480

 Score =  300 bits (769), Expect = 1e-81
 Identities = 152/337 (45%), Positives = 217/337 (64%), Gaps = 14/337 (4%)

Query: 66  LQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQAS 125
           + +F+ ++++G+G++ KV+LV+ K   + YAMK++KKE++   +++    TE  V  Q S
Sbjct: 147 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL-QNS 205

Query: 126 SNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLH 185
            +PFL  L   FQT  RL  V+EY NGG+L FH+ R+R   E+ ARFY AEI  AL++LH
Sbjct: 206 RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLH 265

Query: 186 -ERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEE 244
            E+ ++YRDLKL+N++LD DGHIK+TD+G+CKEG+  G T  TFCGTP Y+APE+L   +
Sbjct: 266 SEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND 325

Query: 245 YGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASH 304
           YG +VDWW LGV+M+EMM GR PF     N D    + LF++IL + IR PR L  +A  
Sbjct: 326 YGRAVDWWGLGVVMYEMMCGRLPF----YNQD---HEKLFELILMEEIRFPRTLGPEAKS 378

Query: 305 VLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDN 364
           +L G L KDPK+RLG   +    +I  H FF  I W  + +K+  PPF+PQ+T +     
Sbjct: 379 LLSGLLKKDPKQRLGGGSEDA-KEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRY 437

Query: 365 FDTQFTSEPVQLTPDDEDAIKRIDQSE----FEGFEY 397
           FD +FT++ + +TP D+D       SE    F  F Y
Sbjct: 438 FDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSY 474


>gi|62241011 AKT1 kinase [Homo sapiens]
          Length = 480

 Score =  300 bits (769), Expect = 1e-81
 Identities = 152/337 (45%), Positives = 217/337 (64%), Gaps = 14/337 (4%)

Query: 66  LQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQAS 125
           + +F+ ++++G+G++ KV+LV+ K   + YAMK++KKE++   +++    TE  V  Q S
Sbjct: 147 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL-QNS 205

Query: 126 SNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLH 185
            +PFL  L   FQT  RL  V+EY NGG+L FH+ R+R   E+ ARFY AEI  AL++LH
Sbjct: 206 RHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLH 265

Query: 186 -ERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEE 244
            E+ ++YRDLKL+N++LD DGHIK+TD+G+CKEG+  G T  TFCGTP Y+APE+L   +
Sbjct: 266 SEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND 325

Query: 245 YGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASH 304
           YG +VDWW LGV+M+EMM GR PF     N D    + LF++IL + IR PR L  +A  
Sbjct: 326 YGRAVDWWGLGVVMYEMMCGRLPF----YNQD---HEKLFELILMEEIRFPRTLGPEAKS 378

Query: 305 VLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDN 364
           +L G L KDPK+RLG   +    +I  H FF  I W  + +K+  PPF+PQ+T +     
Sbjct: 379 LLSGLLKKDPKQRLGGGSEDA-KEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRY 437

Query: 365 FDTQFTSEPVQLTPDDEDAIKRIDQSE----FEGFEY 397
           FD +FT++ + +TP D+D       SE    F  F Y
Sbjct: 438 FDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSY 474


>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
          Length = 479

 Score =  300 bits (768), Expect = 2e-81
 Identities = 151/338 (44%), Positives = 218/338 (64%), Gaps = 15/338 (4%)

Query: 66  LQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQAS 125
           + DFD ++++G+G++ KV+LVR K + + YAMK++KKE++   +++    TE  V +  +
Sbjct: 145 MNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKN-T 203

Query: 126 SNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLH 185
            +PFL  L   FQT  RL  V+EYVNGG+L FH+ R+R   E+  RFY AEI  AL++LH
Sbjct: 204 RHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLH 263

Query: 186 ERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEY 245
              I+YRDLKL+N++LD DGHIK+TD+G+CKEG+    T  TFCGTP Y+APE+L   +Y
Sbjct: 264 SGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDY 323

Query: 246 GFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHV 305
           G +VDWW LGV+M+EMM GR PF     N D    + LF++IL + I+ PR LS  A  +
Sbjct: 324 GRAVDWWGLGVVMYEMMCGRLPF----YNQD---HEKLFELILMEDIKFPRTLSSDAKSL 376

Query: 306 LKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNF 365
           L G L KDP +RLG  P     +I  H+FF  ++W  +  K+ +PPF+PQ+T +     F
Sbjct: 377 LSGLLIKDPNKRLGGGPDDA-KEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYF 435

Query: 366 DTQFTSEPVQLTPD---DEDAIKRID---QSEFEGFEY 397
           D +FT++ + +TP    DED +  +D   +  F  F Y
Sbjct: 436 DEEFTAQTITITPPEKYDEDGMDCMDNERRPHFPQFSY 473


>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
          Length = 465

 Score =  298 bits (762), Expect = 8e-81
 Identities = 144/316 (45%), Positives = 210/316 (66%), Gaps = 9/316 (2%)

Query: 66  LQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQAS 125
           + DFD ++++G+G++ KV+LVR K + + YAMK++KKE++   +++    TE  V +  +
Sbjct: 145 MNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKN-T 203

Query: 126 SNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLH 185
            +PFL  L   FQT  RL  V+EYVNGG+L FH+ R+R   E+  RFY AEI  AL++LH
Sbjct: 204 RHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLH 263

Query: 186 ERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEY 245
              I+YRDLKL+N++LD DGHIK+TD+G+CKEG+    T  TFCGTP Y+APE+L   +Y
Sbjct: 264 SGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDY 323

Query: 246 GFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHV 305
           G +VDWW LGV+M+EMM GR PF     N D    + LF++IL + I+ PR LS  A  +
Sbjct: 324 GRAVDWWGLGVVMYEMMCGRLPF----YNQD---HEKLFELILMEDIKFPRTLSSDAKSL 376

Query: 306 LKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNF 365
           L G L KDP +RLG  P     +I  H+FF  ++W  +  K+ +PPF+PQ+T +     F
Sbjct: 377 LSGLLIKDPNKRLGGGPDDA-KEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYF 435

Query: 366 DTQFTSEPVQLTPDDE 381
           D +FT++ + +TP ++
Sbjct: 436 DEEFTAQTITITPPEK 451


>gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alpha
           [Homo sapiens]
          Length = 367

 Score =  295 bits (756), Expect = 4e-80
 Identities = 151/334 (45%), Positives = 215/334 (64%), Gaps = 14/334 (4%)

Query: 68  DFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSN 127
           DFD ++VIG+G+Y KVLL + K +   YA+KV++K+ +   ++   +  E+ V  +   +
Sbjct: 34  DFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRH 93

Query: 128 PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHER 187
           PFLVGL   FQT  +L+ V++YVNGG+L FH+QR+R+  E  ARFYAAE+  A+ +LH  
Sbjct: 94  PFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSL 153

Query: 188 GIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGF 247
            IIYRDLK +N+LLD  GH+ LTD+G+CKEG+ P DTTSTFCGTP Y+APE+LR E Y  
Sbjct: 154 NIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDR 213

Query: 248 SVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLK 307
           +VDWW LG +++EM+ G  PF     + D++    +++ IL +P++IP   +V A  +L+
Sbjct: 214 AVDWWCLGAVLYEMLHGLPPF----YSQDVS---QMYENILHQPLQIPGGRTVAACDLLQ 266

Query: 308 GFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDT 367
             L+KD ++RLG +    F +IK+H FF  I+WD L  K+  PPF P +T    L +FD 
Sbjct: 267 SLLHKDQRQRLGSK--ADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDP 324

Query: 368 QFTSEPVQ----LTPDDEDAIKRIDQSEFEGFEY 397
           +FT E V      TPD   A      S F GF Y
Sbjct: 325 EFTQEAVSKSIGCTPDTV-ASSSGASSAFLGFSY 357


>gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta
           [Homo sapiens]
          Length = 427

 Score =  295 bits (756), Expect = 4e-80
 Identities = 151/334 (45%), Positives = 215/334 (64%), Gaps = 14/334 (4%)

Query: 68  DFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSN 127
           DFD ++VIG+G+Y KVLL + K +   YA+KV++K+ +   ++   +  E+ V  +   +
Sbjct: 94  DFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRH 153

Query: 128 PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHER 187
           PFLVGL   FQT  +L+ V++YVNGG+L FH+QR+R+  E  ARFYAAE+  A+ +LH  
Sbjct: 154 PFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSL 213

Query: 188 GIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGF 247
            IIYRDLK +N+LLD  GH+ LTD+G+CKEG+ P DTTSTFCGTP Y+APE+LR E Y  
Sbjct: 214 NIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDR 273

Query: 248 SVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLK 307
           +VDWW LG +++EM+ G  PF     + D++    +++ IL +P++IP   +V A  +L+
Sbjct: 274 AVDWWCLGAVLYEMLHGLPPF----YSQDVS---QMYENILHQPLQIPGGRTVAACDLLQ 326

Query: 308 GFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDT 367
             L+KD ++RLG +    F +IK+H FF  I+WD L  K+  PPF P +T    L +FD 
Sbjct: 327 SLLHKDQRQRLGSK--ADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDP 384

Query: 368 QFTSEPVQ----LTPDDEDAIKRIDQSEFEGFEY 397
           +FT E V      TPD   A      S F GF Y
Sbjct: 385 EFTQEAVSKSIGCTPDTV-ASSSGASSAFLGFSY 417


>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
           sapiens]
          Length = 431

 Score =  289 bits (739), Expect = 4e-78
 Identities = 147/339 (43%), Positives = 213/339 (62%), Gaps = 15/339 (4%)

Query: 68  DFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSN 127
           DF  ++VIG+GS+ KVLL R K  +  YA+KV++K+ +   ++   + +E++V  +   +
Sbjct: 97  DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKH 156

Query: 128 PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHER 187
           PFLVGLH  FQT  +L+ V++Y+NGG+L +H+QR+R   E  ARFYAAEI  AL +LH  
Sbjct: 157 PFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSL 216

Query: 188 GIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGF 247
            I+YRDLK +N+LLD+ GHI LTD+G+CKE +    TTSTFCGTP Y+APE+L  + Y  
Sbjct: 217 NIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDR 276

Query: 248 SVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLK 307
           +VDWW LG +++EM+ G  PF         NT + ++  IL KP+++   ++  A H+L+
Sbjct: 277 TVDWWCLGAVLYEMLYGLPPF------YSRNTAE-MYDNILNKPLQLKPNITNSARHLLE 329

Query: 308 GFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDT 367
           G L KD  +RLG +    F +IKSH FF  I+WD L  K+  PPF P ++    L +FD 
Sbjct: 330 GLLQKDRTKRLGAKDD--FMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDP 387

Query: 368 QFTSEPVQ----LTPDDEDAIKRIDQS--EFEGFEYINP 400
           +FT EPV      +PD       + ++   F GF Y  P
Sbjct: 388 EFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPP 426


>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
           [Homo sapiens]
          Length = 445

 Score =  289 bits (739), Expect = 4e-78
 Identities = 147/339 (43%), Positives = 213/339 (62%), Gaps = 15/339 (4%)

Query: 68  DFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSN 127
           DF  ++VIG+GS+ KVLL R K  +  YA+KV++K+ +   ++   + +E++V  +   +
Sbjct: 111 DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKH 170

Query: 128 PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHER 187
           PFLVGLH  FQT  +L+ V++Y+NGG+L +H+QR+R   E  ARFYAAEI  AL +LH  
Sbjct: 171 PFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSL 230

Query: 188 GIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGF 247
            I+YRDLK +N+LLD+ GHI LTD+G+CKE +    TTSTFCGTP Y+APE+L  + Y  
Sbjct: 231 NIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDR 290

Query: 248 SVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLK 307
           +VDWW LG +++EM+ G  PF         NT + ++  IL KP+++   ++  A H+L+
Sbjct: 291 TVDWWCLGAVLYEMLYGLPPF------YSRNTAE-MYDNILNKPLQLKPNITNSARHLLE 343

Query: 308 GFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDT 367
           G L KD  +RLG +    F +IKSH FF  I+WD L  K+  PPF P ++    L +FD 
Sbjct: 344 GLLQKDRTKRLGAKDD--FMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDP 401

Query: 368 QFTSEPVQ----LTPDDEDAIKRIDQS--EFEGFEYINP 400
           +FT EPV      +PD       + ++   F GF Y  P
Sbjct: 402 EFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPP 440


>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
           [Homo sapiens]
          Length = 459

 Score =  289 bits (739), Expect = 4e-78
 Identities = 147/339 (43%), Positives = 213/339 (62%), Gaps = 15/339 (4%)

Query: 68  DFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSN 127
           DF  ++VIG+GS+ KVLL R K  +  YA+KV++K+ +   ++   + +E++V  +   +
Sbjct: 125 DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKH 184

Query: 128 PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHER 187
           PFLVGLH  FQT  +L+ V++Y+NGG+L +H+QR+R   E  ARFYAAEI  AL +LH  
Sbjct: 185 PFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSL 244

Query: 188 GIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGF 247
            I+YRDLK +N+LLD+ GHI LTD+G+CKE +    TTSTFCGTP Y+APE+L  + Y  
Sbjct: 245 NIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDR 304

Query: 248 SVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLK 307
           +VDWW LG +++EM+ G  PF         NT + ++  IL KP+++   ++  A H+L+
Sbjct: 305 TVDWWCLGAVLYEMLYGLPPF------YSRNTAE-MYDNILNKPLQLKPNITNSARHLLE 357

Query: 308 GFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDT 367
           G L KD  +RLG +    F +IKSH FF  I+WD L  K+  PPF P ++    L +FD 
Sbjct: 358 GLLQKDRTKRLGAKDD--FMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDP 415

Query: 368 QFTSEPVQ----LTPDDEDAIKRIDQS--EFEGFEYINP 400
           +FT EPV      +PD       + ++   F GF Y  P
Sbjct: 416 EFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPP 454


>gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2
           [Homo sapiens]
          Length = 526

 Score =  289 bits (739), Expect = 4e-78
 Identities = 147/339 (43%), Positives = 213/339 (62%), Gaps = 15/339 (4%)

Query: 68  DFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSN 127
           DF  ++VIG+GS+ KVLL R K  +  YA+KV++K+ +   ++   + +E++V  +   +
Sbjct: 192 DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKH 251

Query: 128 PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHER 187
           PFLVGLH  FQT  +L+ V++Y+NGG+L +H+QR+R   E  ARFYAAEI  AL +LH  
Sbjct: 252 PFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSL 311

Query: 188 GIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGF 247
            I+YRDLK +N+LLD+ GHI LTD+G+CKE +    TTSTFCGTP Y+APE+L  + Y  
Sbjct: 312 NIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDR 371

Query: 248 SVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLK 307
           +VDWW LG +++EM+ G  PF         NT + ++  IL KP+++   ++  A H+L+
Sbjct: 372 TVDWWCLGAVLYEMLYGLPPF------YSRNTAE-MYDNILNKPLQLKPNITNSARHLLE 424

Query: 308 GFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDT 367
           G L KD  +RLG +    F +IKSH FF  I+WD L  K+  PPF P ++    L +FD 
Sbjct: 425 GLLQKDRTKRLGAKDD--FMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDP 482

Query: 368 QFTSEPVQ----LTPDDEDAIKRIDQS--EFEGFEYINP 400
           +FT EPV      +PD       + ++   F GF Y  P
Sbjct: 483 EFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPP 521


>gi|5453974 protein kinase N2 [Homo sapiens]
          Length = 984

 Score =  288 bits (738), Expect = 5e-78
 Identities = 160/394 (40%), Positives = 228/394 (57%), Gaps = 25/394 (6%)

Query: 20  DLPSEETDGIAYISSSRKHDSIKDDSEDLKPVI--DGMDGIKISQ----------GLGLQ 67
           D+P ++++ +  I + R     K  SE  KP     G++   I +             LQ
Sbjct: 597 DIPGQDSETVFDIQNDRNSILPKSQSE-YKPDTPQSGLEYSGIQELEDRRSQQRFQFNLQ 655

Query: 68  DFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASS- 126
           DF    V+GRG + KVLL   K  ++++A+K +KK  +   +++D +  EK +FE  +S 
Sbjct: 656 DFRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSV 715

Query: 127 -NPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLH 185
            +PFLV L +CFQT   +  V+EY  GGDLM H+       E  A FYAA + + L +LH
Sbjct: 716 RHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTD-VFSEPRAVFYAACVVLGLQYLH 774

Query: 186 ERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEY 245
           E  I+YRDLKLDN+LLD +G +K+ D+G+CKEG+G GD TSTFCGTP ++APE+L    Y
Sbjct: 775 EHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSY 834

Query: 246 GFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHV 305
             +VDWW LGVL++EM+ G SPF         + E+ +F  I+   +R PRFLS +A  +
Sbjct: 835 TRAVDWWGLGVLIYEMLVGESPF-------PGDDEEEVFDSIVNDEVRYPRFLSTEAISI 887

Query: 306 LKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNF 365
           ++  L ++P+ RLG   +    D+K H FFR IDW  L  K+  PPF P I     + NF
Sbjct: 888 MRRLLRRNPERRLGASEKDA-EDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNF 946

Query: 366 DTQFTSEPVQLTPDDEDAIKRIDQSE-FEGFEYI 398
           D +FTSE   LTP  E  I   ++ E F  F+YI
Sbjct: 947 DDEFTSEAPILTPPREPRILSEEEQEMFRDFDYI 980


>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
           sapiens]
          Length = 496

 Score =  288 bits (736), Expect = 8e-78
 Identities = 147/339 (43%), Positives = 215/339 (63%), Gaps = 15/339 (4%)

Query: 68  DFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSN 127
           DFD ++VIG+GS+ KVLL + K + + YA+KV++K++V + ++   +  E++V  +   +
Sbjct: 161 DFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKH 220

Query: 128 PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHER 187
           PFLVGLH  FQTT +L+ V+++VNGG+L FH+QR+R  PE  ARFYAAEI  AL +LH  
Sbjct: 221 PFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSI 280

Query: 188 GIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGF 247
            I+YRDLK +N+LLD+ GH+ LTD+G+CKEG+   DTT+TFCGTP Y+APE++R + Y  
Sbjct: 281 KIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDN 340

Query: 248 SVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLK 307
           +VDWW LG +++EM+ G  PF    D  +M      +  IL KP+ +   +S+ A  +L+
Sbjct: 341 TVDWWCLGAVLYEMLYGLPPF-YCRDVAEM------YDNILHKPLSLRPGVSLTAWSILE 393

Query: 308 GFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDT 367
             L KD + RLG +    F +I++H FF S+ W  L +K+  PPF P +     + NFDT
Sbjct: 394 ELLEKDRQNRLGAKED--FLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDT 451

Query: 368 QFTSE--PVQLTPDDEDAIKRIDQSE----FEGFEYINP 400
            FT E  P  +    + +I      E    F GF Y  P
Sbjct: 452 AFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPP 490


>gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
           sapiens]
          Length = 496

 Score =  288 bits (736), Expect = 8e-78
 Identities = 147/339 (43%), Positives = 215/339 (63%), Gaps = 15/339 (4%)

Query: 68  DFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSN 127
           DFD ++VIG+GS+ KVLL + K + + YA+KV++K++V + ++   +  E++V  +   +
Sbjct: 161 DFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKH 220

Query: 128 PFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHER 187
           PFLVGLH  FQTT +L+ V+++VNGG+L FH+QR+R  PE  ARFYAAEI  AL +LH  
Sbjct: 221 PFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSI 280

Query: 188 GIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGF 247
            I+YRDLK +N+LLD+ GH+ LTD+G+CKEG+   DTT+TFCGTP Y+APE++R + Y  
Sbjct: 281 KIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDN 340

Query: 248 SVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLK 307
           +VDWW LG +++EM+ G  PF    D  +M      +  IL KP+ +   +S+ A  +L+
Sbjct: 341 TVDWWCLGAVLYEMLYGLPPF-YCRDVAEM------YDNILHKPLSLRPGVSLTAWSILE 393

Query: 308 GFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDT 367
             L KD + RLG +    F +I++H FF S+ W  L +K+  PPF P +     + NFDT
Sbjct: 394 ELLEKDRQNRLGAKED--FLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDT 451

Query: 368 QFTSE--PVQLTPDDEDAIKRIDQSE----FEGFEYINP 400
            FT E  P  +    + +I      E    F GF Y  P
Sbjct: 452 AFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPP 490


>gi|47132591 protein kinase N1 isoform 1 [Homo sapiens]
          Length = 948

 Score =  270 bits (689), Expect = 2e-72
 Identities = 135/338 (39%), Positives = 206/338 (60%), Gaps = 12/338 (3%)

Query: 64  LGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQ 123
           L L+DF  + V+GRG + KVLL   + + +++A+K +KK  +   ++++ +  EK +   
Sbjct: 616 LTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAA 675

Query: 124 ASS--NPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIAL 181
            +S  +PFLV L  CFQT   +  V+EY  GGDLM H+       E  A FY+A + + L
Sbjct: 676 VTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSD-VFSEPRAIFYSACVVLGL 734

Query: 182 NFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILR 241
            FLHE  I+YRDLKLDN+LLD +G++K+ D+G+CKEG+G GD TSTFCGTP ++APE+L 
Sbjct: 735 QFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLT 794

Query: 242 GEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVK 301
              Y  +VDWW LGVL++EM+ G SPF         + E+ +F  I+   +R PRFLS +
Sbjct: 795 DTSYTRAVDWWGLGVLLYEMLVGESPF-------PGDDEEEVFDSIVNDEVRYPRFLSAE 847

Query: 302 ASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYG 361
           A  +++  L ++P+ RLG   +    D+K   FFR++ W+ L  ++  PPF P ++    
Sbjct: 848 AIGIMRRLLRRNPERRLGSSERDA-EDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTD 906

Query: 362 LDNFDTQFTSE-PVQLTPDDEDAIKRIDQSEFEGFEYI 398
           + NFD +FT E P    P D   +   +Q+ F  F+++
Sbjct: 907 VSNFDEEFTGEAPTLSPPRDARPLTAAEQAAFLDFDFV 944


>gi|47132589 protein kinase N1 isoform 2 [Homo sapiens]
          Length = 942

 Score =  270 bits (689), Expect = 2e-72
 Identities = 135/338 (39%), Positives = 206/338 (60%), Gaps = 12/338 (3%)

Query: 64  LGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQ 123
           L L+DF  + V+GRG + KVLL   + + +++A+K +KK  +   ++++ +  EK +   
Sbjct: 610 LTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAA 669

Query: 124 ASS--NPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIAL 181
            +S  +PFLV L  CFQT   +  V+EY  GGDLM H+       E  A FY+A + + L
Sbjct: 670 VTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSD-VFSEPRAIFYSACVVLGL 728

Query: 182 NFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILR 241
            FLHE  I+YRDLKLDN+LLD +G++K+ D+G+CKEG+G GD TSTFCGTP ++APE+L 
Sbjct: 729 QFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLT 788

Query: 242 GEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVK 301
              Y  +VDWW LGVL++EM+ G SPF         + E+ +F  I+   +R PRFLS +
Sbjct: 789 DTSYTRAVDWWGLGVLLYEMLVGESPF-------PGDDEEEVFDSIVNDEVRYPRFLSAE 841

Query: 302 ASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYG 361
           A  +++  L ++P+ RLG   +    D+K   FFR++ W+ L  ++  PPF P ++    
Sbjct: 842 AIGIMRRLLRRNPERRLGSSERDA-EDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTD 900

Query: 362 LDNFDTQFTSE-PVQLTPDDEDAIKRIDQSEFEGFEYI 398
           + NFD +FT E P    P D   +   +Q+ F  F+++
Sbjct: 901 VSNFDEEFTGEAPTLSPPRDARPLTAAEQAAFLDFDFV 938


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.139    0.416 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,325,729
Number of Sequences: 37866
Number of extensions: 759810
Number of successful extensions: 3767
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 690
Number of HSP's successfully gapped in prelim test: 106
Number of HSP's that attempted gapping in prelim test: 1607
Number of HSP's gapped (non-prelim): 946
length of query: 409
length of database: 18,247,518
effective HSP length: 105
effective length of query: 304
effective length of database: 14,271,588
effective search space: 4338562752
effective search space used: 4338562752
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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