Guide to the Human Genome
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Search of human proteins with 75677576

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|75677576 dyslexia susceptibility 1 candidate 1 isoform c
[Homo sapiens]
         (381 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|75677576 dyslexia susceptibility 1 candidate 1 isoform c [Hom...   757   0.0  
gi|75677567 dyslexia susceptibility 1 candidate 1 isoform b [Hom...   691   0.0  
gi|75677570 dyslexia susceptibility 1 candidate 1 isoform a [Hom...   691   0.0  
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa...    60   2e-09
gi|41152097 DNA segment on chromosome X and Y (unique) 155 expre...    56   6e-08
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]                       56   6e-08
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi...    55   1e-07
gi|116089325 splicing factor, arginine/serine-rich 12 isoform a ...    55   1e-07
gi|21040255 splicing factor, arginine/serine-rich 12 isoform b [...    55   1e-07
gi|18375528 UPF3 regulator of nonsense transcripts homolog B iso...    54   2e-07
gi|102467242 inner centromere protein antigens 135/155kDa isofor...    54   2e-07
gi|120953300 leucine-rich repeats and IQ motif containing 1 isof...    54   3e-07
gi|120953243 leucine-rich repeats and IQ motif containing 1 isof...    54   3e-07
gi|94538370 DnaJ (Hsp40) homolog, subfamily C, member 2 isoform ...    53   5e-07
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap...    51   2e-06
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap...    51   2e-06
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap...    51   2e-06
gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi...    51   2e-06
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa...    50   3e-06
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li...    50   3e-06
gi|116686122 kinesin family member 4 [Homo sapiens]                    50   3e-06
gi|88759339 aster-associated protein [Homo sapiens]                    50   3e-06
gi|5803181 stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizi...    50   3e-06
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap...    50   3e-06
gi|4506921 small glutamine-rich tetratricopeptide [Homo sapiens]       50   3e-06
gi|102467235 inner centromere protein antigens 135/155kDa isofor...    50   3e-06
gi|12711674 UPF3 regulator of nonsense transcripts homolog B iso...    50   3e-06
gi|27262638 sperm associated antigen 1 [Homo sapiens]                  50   3e-06
gi|27262636 sperm associated antigen 1 [Homo sapiens]                  50   3e-06
gi|148746195 trichohyalin [Homo sapiens]                               49   6e-06

>gi|75677576 dyslexia susceptibility 1 candidate 1 isoform c [Homo
           sapiens]
          Length = 381

 Score =  757 bits (1955), Expect = 0.0
 Identities = 381/381 (100%), Positives = 381/381 (100%)

Query: 1   MPLQVSDYSWQQTKTAVFLSLPLKGVCVRDTDVFCTENYLKVNFPPFLFEAFLYAPIDDE 60
           MPLQVSDYSWQQTKTAVFLSLPLKGVCVRDTDVFCTENYLKVNFPPFLFEAFLYAPIDDE
Sbjct: 1   MPLQVSDYSWQQTKTAVFLSLPLKGVCVRDTDVFCTENYLKVNFPPFLFEAFLYAPIDDE 60

Query: 61  SSKAKIGNDTIVFTLYKKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAA 120
           SSKAKIGNDTIVFTLYKKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAA
Sbjct: 61  SSKAKIGNDTIVFTLYKKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAA 120

Query: 121 AKREDQKYALSVMMKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQREEK 180
           AKREDQKYALSVMMKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQREEK
Sbjct: 121 AKREDQKYALSVMMKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQREEK 180

Query: 181 LCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKI 240
           LCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKI
Sbjct: 181 LCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKI 240

Query: 241 NFTPRVFPTALRESQVAEEEEWLHKQAEARRAMNTDIAELCDLKEEEKNPEWLKDKGNKL 300
           NFTPRVFPTALRESQVAEEEEWLHKQAEARRAMNTDIAELCDLKEEEKNPEWLKDKGNKL
Sbjct: 241 NFTPRVFPTALRESQVAEEEEWLHKQAEARRAMNTDIAELCDLKEEEKNPEWLKDKGNKL 300

Query: 301 FATENYLAAINAYNLAIRLNNKMPLLYLNRAACHLKLKNLHKAIEDSSKEFCSLEGIECQ 360
           FATENYLAAINAYNLAIRLNNKMPLLYLNRAACHLKLKNLHKAIEDSSKEFCSLEGIECQ
Sbjct: 301 FATENYLAAINAYNLAIRLNNKMPLLYLNRAACHLKLKNLHKAIEDSSKEFCSLEGIECQ 360

Query: 361 ASEPKLSHHIPSDLHVYIQMA 381
           ASEPKLSHHIPSDLHVYIQMA
Sbjct: 361 ASEPKLSHHIPSDLHVYIQMA 381


>gi|75677567 dyslexia susceptibility 1 candidate 1 isoform b [Homo
           sapiens]
          Length = 376

 Score =  691 bits (1784), Expect = 0.0
 Identities = 349/351 (99%), Positives = 350/351 (99%)

Query: 1   MPLQVSDYSWQQTKTAVFLSLPLKGVCVRDTDVFCTENYLKVNFPPFLFEAFLYAPIDDE 60
           MPLQVSDYSWQQTKTAVFLSLPLKGVCVRDTDVFCTENYLKVNFPPFLFEAFLYAPIDDE
Sbjct: 1   MPLQVSDYSWQQTKTAVFLSLPLKGVCVRDTDVFCTENYLKVNFPPFLFEAFLYAPIDDE 60

Query: 61  SSKAKIGNDTIVFTLYKKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAA 120
           SSKAKIGNDTIVFTLYKKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAA
Sbjct: 61  SSKAKIGNDTIVFTLYKKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAA 120

Query: 121 AKREDQKYALSVMMKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQREEK 180
           AKREDQKYALSVMMKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQREEK
Sbjct: 121 AKREDQKYALSVMMKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQREEK 180

Query: 181 LCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKI 240
           LCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKI
Sbjct: 181 LCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKI 240

Query: 241 NFTPRVFPTALRESQVAEEEEWLHKQAEARRAMNTDIAELCDLKEEEKNPEWLKDKGNKL 300
           NFTPRVFPTALRESQVAEEEEWLHKQAEARRAMNTDIAELCDLKEEEKNPEWLKDKGNKL
Sbjct: 241 NFTPRVFPTALRESQVAEEEEWLHKQAEARRAMNTDIAELCDLKEEEKNPEWLKDKGNKL 300

Query: 301 FATENYLAAINAYNLAIRLNNKMPLLYLNRAACHLKLKNLHKAIEDSSKEF 351
           FATENYLAAINAYNLAIRLNNKMPLLYLNRAACHLKLKNLHKAIEDSSK +
Sbjct: 301 FATENYLAAINAYNLAIRLNNKMPLLYLNRAACHLKLKNLHKAIEDSSKAY 351


>gi|75677570 dyslexia susceptibility 1 candidate 1 isoform a [Homo
           sapiens]
          Length = 420

 Score =  691 bits (1782), Expect = 0.0
 Identities = 349/349 (100%), Positives = 349/349 (100%)

Query: 1   MPLQVSDYSWQQTKTAVFLSLPLKGVCVRDTDVFCTENYLKVNFPPFLFEAFLYAPIDDE 60
           MPLQVSDYSWQQTKTAVFLSLPLKGVCVRDTDVFCTENYLKVNFPPFLFEAFLYAPIDDE
Sbjct: 1   MPLQVSDYSWQQTKTAVFLSLPLKGVCVRDTDVFCTENYLKVNFPPFLFEAFLYAPIDDE 60

Query: 61  SSKAKIGNDTIVFTLYKKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAA 120
           SSKAKIGNDTIVFTLYKKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAA
Sbjct: 61  SSKAKIGNDTIVFTLYKKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAA 120

Query: 121 AKREDQKYALSVMMKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQREEK 180
           AKREDQKYALSVMMKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQREEK
Sbjct: 121 AKREDQKYALSVMMKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQREEK 180

Query: 181 LCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKI 240
           LCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKI
Sbjct: 181 LCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKI 240

Query: 241 NFTPRVFPTALRESQVAEEEEWLHKQAEARRAMNTDIAELCDLKEEEKNPEWLKDKGNKL 300
           NFTPRVFPTALRESQVAEEEEWLHKQAEARRAMNTDIAELCDLKEEEKNPEWLKDKGNKL
Sbjct: 241 NFTPRVFPTALRESQVAEEEEWLHKQAEARRAMNTDIAELCDLKEEEKNPEWLKDKGNKL 300

Query: 301 FATENYLAAINAYNLAIRLNNKMPLLYLNRAACHLKLKNLHKAIEDSSK 349
           FATENYLAAINAYNLAIRLNNKMPLLYLNRAACHLKLKNLHKAIEDSSK
Sbjct: 301 FATENYLAAINAYNLAIRLNNKMPLLYLNRAACHLKLKNLHKAIEDSSK 349


>gi|84043963 eukaryotic translation initiation factor 5B [Homo
           sapiens]
          Length = 1220

 Score = 60.5 bits (145), Expect = 2e-09
 Identities = 70/262 (26%), Positives = 117/262 (44%), Gaps = 34/262 (12%)

Query: 58  DDESSKAKIGNDTIVFTLYKKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEA 117
           ++E+ K+K+  DT V    +++A   ET +    D E  ++ ++K   + ++  KE  + 
Sbjct: 277 EEETVKSKVTVDTGVIPASEEKA---ETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKK 333

Query: 118 KAAAKREDQKYALSVMMKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQR 177
           K  +K   +    ++    EEEER+K E   E ERIK  + LEA    +RK EE+ + ++
Sbjct: 334 KGPSKATVKAMQEALAKLKEEEERQKRE---EEERIKRLEELEA----KRKEEERLEQEK 386

Query: 178 EEKLCQKEKQIKEERK---KIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAPRS 234
            E+  QKEK+ KE  K   K+  KS     A      K   ++ +  E   +DS+P  R 
Sbjct: 387 RERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGV--EVPSKDSLPKKRP 444

Query: 235 VGSIKINFTPRVFPTALRESQVAE----------------EEEWLHKQAEARRAMNTDIA 278
           +   K     +  P  L   +V+E                E+E      E     +T+ A
Sbjct: 445 IYEDK---KRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDA 501

Query: 279 ELCDLKEEEKNPEWLKDKGNKL 300
            L D +    + E  K +GNK+
Sbjct: 502 GLDDWEAMASDEETEKVEGNKV 523



 Score = 29.6 bits (65), Expect = 4.7
 Identities = 20/67 (29%), Positives = 33/67 (49%), Gaps = 9/67 (13%)

Query: 107 AQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENERIKATKALEA-WKEY 165
           A  + K   + KA  K  ++K          +EE+ K+  +KE E ++  K  ++  KE 
Sbjct: 221 ASFKIKTVAQKKAEKKERERKK--------RDEEKAKLRKLKEKEELETGKKDQSKQKES 272

Query: 166 QRKAEEQ 172
           QRK EE+
Sbjct: 273 QRKFEEE 279



 Score = 29.3 bits (64), Expect = 6.2
 Identities = 34/162 (20%), Positives = 67/162 (41%), Gaps = 27/162 (16%)

Query: 148 KENERIKATKALEAWKE-----YQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTR 202
           K+N++ K    +E+  E     ++ K   QKK +++E+  +K  + K + +K+K K    
Sbjct: 201 KKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKE--- 257

Query: 203 NLASRNLAPKGRNSENIFTEKLKEDSIPAPRSV--GSIKINFTPRVFPTALRESQVA--- 257
                    K ++ +     K +E+++ +  +V  G I  +      PTA  +       
Sbjct: 258 ---ELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKK 314

Query: 258 -----------EEEEWLHKQAEARRAMNTDIAELCDLKEEEK 288
                      EE+E   K+  ++  +      L  LKEEE+
Sbjct: 315 KKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEE 356



 Score = 29.3 bits (64), Expect = 6.2
 Identities = 31/119 (26%), Positives = 50/119 (42%), Gaps = 20/119 (16%)

Query: 122 KREDQKYALSVMMKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQRE--- 178
           K E  K  + V    EEEE ++ E+ +E+E  +  +  E   E     EE +K+  E   
Sbjct: 517 KVEGNKVHIEVKENPEEEEEEE-EEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDS 575

Query: 179 ----EKLCQKEKQIKEE--------RKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLK 225
               +K   KE     E        +++  Y    R +  R L     +S+N+ TEKL+
Sbjct: 576 GKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRIEKRRL----EHSKNVNTEKLR 630


>gi|41152097 DNA segment on chromosome X and Y (unique) 155
           expressed sequence isoform 1 [Homo sapiens]
          Length = 695

 Score = 55.8 bits (133), Expect = 6e-08
 Identities = 50/218 (22%), Positives = 105/218 (48%), Gaps = 15/218 (6%)

Query: 93  KEMMQRIREKSILQAQERAKEATEAKAAAKR-----EDQKYALSVMMKIEEEERKKIEDM 147
           +E M  I+  S L+  +   +  + KA A       +  K+     +K  + ER+K++++
Sbjct: 222 REYMGFIQAMSALRGMKLMYKGEDGKAVACNIKVSFDSTKHLSDASIKKRQLERQKLQEL 281

Query: 148 KENERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASR 207
           ++    +  +  EA +  + +  +QK+++  E+  ++E+++++  +K + + L RN   +
Sbjct: 282 EQQREEQKRREKEAEERQRAEERKQKELEELERERKREEKLRKREQKQRDRELRRN--QK 339

Query: 208 NLAPKGRNSENIFTEKLKEDS---IPAPRSVGSIKI--NFTPRVFPTALRESQVAEEEEW 262
            L       +    EK+K +    + A R++ SI++      R     LRE +  EE+  
Sbjct: 340 KLEKLQAEEQKQLQEKIKLEERKLLLAQRNLQSIRLIAELLSRAKAVKLREQEQKEEKLR 399

Query: 263 LHKQAEARRAMNTDIAELCDLKEEEKNPEWLKDKGNKL 300
           L +Q E RR      AEL  ++EE++    L+ K  +L
Sbjct: 400 LQQQEERRRLQE---AELRRVEEEKERALGLQRKEREL 434



 Score = 33.9 bits (76), Expect = 0.25
 Identities = 31/145 (21%), Positives = 70/145 (48%), Gaps = 12/145 (8%)

Query: 92  DKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSV------MMKIEEEERKKIE 145
           + E  QR  E+   + +E  +E    +   KRE ++    +      + K++ EE+K+++
Sbjct: 294 EAEERQRAEERKQKELEELERERKREEKLRKREQKQRDRELRRNQKKLEKLQAEEQKQLQ 353

Query: 146 D---MKENERIKATKALEAWK---EYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKS 199
           +   ++E + + A + L++ +   E   +A+  K  ++E+K  +   Q +EER++++   
Sbjct: 354 EKIKLEERKLLLAQRNLQSIRLIAELLSRAKAVKLREQEQKEEKLRLQQQEERRRLQEAE 413

Query: 200 LTRNLASRNLAPKGRNSENIFTEKL 224
           L R    +  A   +  E    E+L
Sbjct: 414 LRRVEEEKERALGLQRKERELRERL 438


>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
          Length = 793

 Score = 55.8 bits (133), Expect = 6e-08
 Identities = 42/131 (32%), Positives = 72/131 (54%), Gaps = 8/131 (6%)

Query: 78  KEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIE 137
           KE A  E   +   ++E ++  ++K I  A ERA+   E KAAA+  +++ A     ++ 
Sbjct: 262 KERAEAERARLEAEERERIKAEQDKKI--ADERARIEAEEKAAAQERERREA-EERERMR 318

Query: 138 EEERKKIED---MKENERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQ--IKEER 192
           EEE++  E+   +KE E+  A +     +E +R AEE+++I+ EEK   +E+Q    EE 
Sbjct: 319 EEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEE 378

Query: 193 KKIKYKSLTRN 203
           +K K +   RN
Sbjct: 379 EKAKVEEQKRN 389



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 40/146 (27%), Positives = 74/146 (50%), Gaps = 12/146 (8%)

Query: 58  DDESSKAKIGNDTIVFTLYKKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEA 117
           +++  +  IG + +   + +K     E   V  +    +     K   Q +ER + + E 
Sbjct: 195 EEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPK---QEEEREQGSDEI 251

Query: 118 KAAAK--REDQKYALSVMMKIEEEERKKI---EDMK---ENERIKATKALEAWKEYQRKA 169
               K   ED++ A +   ++E EER++I   +D K   E  RI+A +   A +  +R+A
Sbjct: 252 SHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREA 311

Query: 170 EEQKKIQREEKLCQKEKQ-IKEERKK 194
           EE+++++ EEK   +E+Q IKEE K+
Sbjct: 312 EERERMREEEKRAAEERQRIKEEEKR 337



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 38/140 (27%), Positives = 70/140 (50%), Gaps = 19/140 (13%)

Query: 92  DKEMMQRIREKSILQAQERAKEATEAKAAAK-----REDQKYALSVMMKIEEEERKKIED 146
           + E  +R+RE+    A+ER +   E K AA+     +E++K A     +I+EEE++  E 
Sbjct: 310 EAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAE- 368

Query: 147 MKENERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLAS 206
             E +R +A       +E + K EEQK+ ++ E     EK+   +  KIK + + + +  
Sbjct: 369 --ERQRARAE------EEEKAKVEEQKRNKQLE-----EKKHAMQETKIKGEKVEQKIEG 415

Query: 207 RNLAPKGRNSENIFTEKLKE 226
           + +  K    + + T  LK+
Sbjct: 416 KWVNEKKAQEDKLQTAVLKK 435



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 58/253 (22%), Positives = 107/253 (42%), Gaps = 60/253 (23%)

Query: 94  EMMQRIREKSILQAQERAKEATEAKAAAK-----REDQKYALSVMMKI--EEEERKKIED 146
           E  QRI+E+    A+ER +   E K AA+     +E++K A     +   EEEE+ K+E+
Sbjct: 326 EERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEE 385

Query: 147 MKENERI---------------KATKALEAWKEYQRKAEEQK---------------KIQ 176
            K N+++               K  + +E     ++KA+E K               K+Q
Sbjct: 386 QKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQ 445

Query: 177 ------REEKLCQKEKQIKEERKK------------IKYKSLTRNLASRN---LAPKGRN 215
                 +E+K   K+++IK+E+ K            +  K     + S+N   +  K ++
Sbjct: 446 AKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKH 505

Query: 216 SENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPTALRESQVAEEEEWLHKQAEARRAMNT 275
           +EN F+      S+    + G+ ++    R+     R  +   EE    KQ +   A+  
Sbjct: 506 TENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAAL-- 563

Query: 276 DIAELCDLKEEEK 288
           ++ EL   +EE +
Sbjct: 564 ELEELKKKREERR 576



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 49/234 (20%), Positives = 100/234 (42%), Gaps = 26/234 (11%)

Query: 78  KEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIE 137
           K  ++ E      V+++  +   E  ++  +     + E K   +RE     +S   K+E
Sbjct: 199 KRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKME 258

Query: 138 EEERKKIE------DMKENERIKATKALEAWKEYQR-------KAEEQKKIQRE--EKLC 182
           EE++++ E      + +E ERIKA +  +   E  R        A+E+++ + E  E++ 
Sbjct: 259 EEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMR 318

Query: 183 QKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKINF 242
           ++EK+  EER++IK +   R    R    +         +++KE+   A           
Sbjct: 319 EEEKRAAEERQRIKEEE-KRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEE-------- 369

Query: 243 TPRVFPTALRESQVAEEEEWLHKQAEARRAMNTDIAELCDLKEEEKNPEWLKDK 296
             R    A  E +   EE+  +KQ E ++    +     +  E++   +W+ +K
Sbjct: 370 --RQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEK 421



 Score = 35.4 bits (80), Expect = 0.086
 Identities = 42/181 (23%), Positives = 83/181 (45%), Gaps = 25/181 (13%)

Query: 100 REKSILQAQERAKE----ATEAKAA--AKREDQKYALSVMMKIEE--EERKKIEDMKENE 151
           R+K + +A ER KE     T+A  +  ++R     A +   + EE  E R++  +++E E
Sbjct: 107 RQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETE 166

Query: 152 RIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAP 211
            +  +     W++ +   +E K+ + EE+   K   I E + ++  +  T       +  
Sbjct: 167 TVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVM 226

Query: 212 KGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPTALRESQVAEEEEWLHKQAEARR 271
             +N + I +E+ K++     R  GS +I+   ++           EEE+   ++AEA R
Sbjct: 227 SLKNGQ-ISSEEPKQEE---EREQGSDEISHHEKM-----------EEED--KERAEAER 269

Query: 272 A 272
           A
Sbjct: 270 A 270



 Score = 35.0 bits (79), Expect = 0.11
 Identities = 24/118 (20%), Positives = 56/118 (47%), Gaps = 4/118 (3%)

Query: 113 EATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQ 172
           +  EA+ A + E  K    +  +  E E ++ E +K+ ++  A +     +E ++K EE+
Sbjct: 520 DTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALEL----EELKKKREER 575

Query: 173 KKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIP 230
           +K+  EE+  +K+++   + ++ + K   +    R  A      + +  + L +D  P
Sbjct: 576 RKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKP 633



 Score = 32.0 bits (71), Expect = 0.95
 Identities = 33/125 (26%), Positives = 58/125 (46%), Gaps = 24/125 (19%)

Query: 92  DKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIE--DMKE 149
           + E  +++++K     QE A E  E K   KRE+++  L      EEE+R+K E  D K 
Sbjct: 547 ESEEFEKLKQKQ----QEAALELEELK--KKREERRKVLE-----EEEQRRKQEEADRKL 595

Query: 150 NERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIK-----------EERKKIKYK 198
            E  +  +  E  +  + +A E+++   E+ L   +K  K           EER +   K
Sbjct: 596 REEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNK 655

Query: 199 SLTRN 203
           S+ ++
Sbjct: 656 SVQKS 660


>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
           sapiens]
          Length = 436

 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 47/223 (21%), Positives = 101/223 (45%), Gaps = 22/223 (9%)

Query: 77  KKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSV---- 132
           ++E  M E     G  +E MQ+ +E+ + + +E+ ++  E     + + QK    V    
Sbjct: 196 EQEGQMGEQEEQMGEQEEQMQK-QEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQE 254

Query: 133 --MMKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKE 190
             M K EE+ R++ E M+E E     +  +  +E Q   +E++  ++EE++ ++E+Q++E
Sbjct: 255 EQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMRE 314

Query: 191 ERKKIKYKSLTRNLASRNLAPKGRNSENIFTEK-----LKEDSIPAPRSVGSIKINFTPR 245
           + ++++ +              G+  E ++ +K      KE        +G  +     +
Sbjct: 315 QEEQMREQE----------EQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQ 364

Query: 246 VFPTALRESQVAEEEEWLHKQAEARRAMNTDIAELCDLKEEEK 288
                 +E Q+ ++EE + KQ E  R     + E  +   E+K
Sbjct: 365 EEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQK 407



 Score = 42.7 bits (99), Expect = 5e-04
 Identities = 34/115 (29%), Positives = 56/115 (48%), Gaps = 14/115 (12%)

Query: 77  KKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKI 136
           K+E  MWE        KE M +  E+   Q ++  K+  + +   K+E+Q      M K 
Sbjct: 328 KQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVR---KQEEQ------MRKQ 378

Query: 137 EEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEE 191
           EE+ RK+ E M++ E     + +   KE   + +EQ + Q E+   QKE+  K+E
Sbjct: 379 EEQMRKQEEQMRKQE-----EQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQE 428



 Score = 40.8 bits (94), Expect = 0.002
 Identities = 41/208 (19%), Positives = 85/208 (40%), Gaps = 34/208 (16%)

Query: 90  GVDKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEE-RKKIEDMK 148
           G  +E   ++RE+     ++  +   + +   ++E+Q       M  +EE+ RK+ E M 
Sbjct: 178 GQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMG 237

Query: 149 ENERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRN 208
           E E     + ++  +E  +K EEQ + Q E+   Q+E+  ++E + +K K  T       
Sbjct: 238 EQE-----EQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTG 292

Query: 209 LAPKGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPTALRESQVAEEEEWLHKQAE 268
              +    +    E+++E                         +E Q+ E+EE + +Q E
Sbjct: 293 EQEEQMREQE---EQMRE-------------------------QEEQMREQEEQMREQEE 324

Query: 269 ARRAMNTDIAELCDLKEEEKNPEWLKDK 296
                   + E  +   E+K   W +++
Sbjct: 325 QMGKQEEQMWEQKEQMWEQKEQMWKQEE 352



 Score = 38.1 bits (87), Expect = 0.013
 Identities = 34/126 (26%), Positives = 60/126 (47%), Gaps = 14/126 (11%)

Query: 77  KKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKI 136
           ++E  M E     G  +E M   +E+   Q ++  K+  +     ++E+Q      M K 
Sbjct: 314 EQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQM---GEQEEQ------MQKQ 364

Query: 137 EEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIK 196
           EE+ RK+ E M++ E     + +   +E  RK EEQ   Q+E+   QKE+  ++E +  +
Sbjct: 365 EEQVRKQEEQMRKQE-----EQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGE 419

Query: 197 YKSLTR 202
            K   R
Sbjct: 420 QKEQMR 425



 Score = 37.0 bits (84), Expect = 0.030
 Identities = 30/111 (27%), Positives = 56/111 (50%), Gaps = 21/111 (18%)

Query: 75  LYKKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMM 134
           +++++  MW+     G  +E MQ+ +E+ + + +E+ +         K+E+Q      M 
Sbjct: 340 MWEQKEQMWKQEEQMGEQEEQMQK-QEEQVRKQEEQMR---------KQEEQ------MR 383

Query: 135 KIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKE 185
           K EE+ RK+ E M E +     + +   KE  R+ EEQ   Q+E+   Q+E
Sbjct: 384 KQEEQMRKQEEQMGEQK-----EQMGEQKEQMREQEEQMGEQKEQMRKQEE 429


>gi|116089325 splicing factor, arginine/serine-rich 12 isoform a
           [Homo sapiens]
          Length = 624

 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 53/204 (25%), Positives = 97/204 (47%), Gaps = 18/204 (8%)

Query: 97  QRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENERIKAT 156
           +R++EK   + +ER KE  + K   K +D+          +E E+ + +D +++   +  
Sbjct: 388 ERVKEKDREKEREREKEREKEKERGKNKDRD---------KEREKDREKDKEKDRERERE 438

Query: 157 KALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNS 216
           K  E  ++ +++ E+ K+ +RE+    + K+I E+RKK K KS T    S N + + R+S
Sbjct: 439 KEHEKDRDKEKEKEQDKEKEREK---DRSKEIDEKRKKDK-KSRTPP-RSYNASRRSRSS 493

Query: 217 ENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPTALRESQVAEEEEWLHKQAEARRAMNTD 276
                 +    S  +PR+  +IK   +    P +  +     E+E  H      R  +T 
Sbjct: 494 SRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTS 553

Query: 277 IAELC---DLKEE-EKNPEWLKDK 296
           + +     D KE+ EKN   LK+K
Sbjct: 554 MRKSSNDRDGKEKLEKNSTSLKEK 577



 Score = 32.0 bits (71), Expect = 0.95
 Identities = 22/112 (19%), Positives = 48/112 (42%)

Query: 106 QAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENERIKATKALEAWKEY 165
           ++  R+K  + +K+ ++R+  +             R+K     ++   K +K+ E  K  
Sbjct: 309 RSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSR 368

Query: 166 QRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSE 217
            R     K+    EK+ +KE+  +++R+K + +   R         K R+ E
Sbjct: 369 SRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKE 420


>gi|21040255 splicing factor, arginine/serine-rich 12 isoform b
           [Homo sapiens]
          Length = 508

 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 53/204 (25%), Positives = 97/204 (47%), Gaps = 18/204 (8%)

Query: 97  QRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENERIKAT 156
           +R++EK   + +ER KE  + K   K +D+          +E E+ + +D +++   +  
Sbjct: 272 ERVKEKDREKEREREKEREKEKERGKNKDRD---------KEREKDREKDKEKDRERERE 322

Query: 157 KALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNS 216
           K  E  ++ +++ E+ K+ +RE+    + K+I E+RKK K KS T    S N + + R+S
Sbjct: 323 KEHEKDRDKEKEKEQDKEKEREK---DRSKEIDEKRKKDK-KSRTPP-RSYNASRRSRSS 377

Query: 217 ENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPTALRESQVAEEEEWLHKQAEARRAMNTD 276
                 +    S  +PR+  +IK   +    P +  +     E+E  H      R  +T 
Sbjct: 378 SRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTS 437

Query: 277 IAELC---DLKEE-EKNPEWLKDK 296
           + +     D KE+ EKN   LK+K
Sbjct: 438 MRKSSNDRDGKEKLEKNSTSLKEK 461



 Score = 32.0 bits (71), Expect = 0.95
 Identities = 22/112 (19%), Positives = 48/112 (42%)

Query: 106 QAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENERIKATKALEAWKEY 165
           ++  R+K  + +K+ ++R+  +             R+K     ++   K +K+ E  K  
Sbjct: 193 RSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSR 252

Query: 166 QRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSE 217
            R     K+    EK+ +KE+  +++R+K + +   R         K R+ E
Sbjct: 253 SRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKE 304


>gi|18375528 UPF3 regulator of nonsense transcripts homolog B
           isoform 1 [Homo sapiens]
          Length = 483

 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 51/214 (23%), Positives = 100/214 (46%), Gaps = 14/214 (6%)

Query: 97  QRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEER-KKIEDMKENERIKA 155
           QR+RE+   + +ER +   E K   + E +K+      K ++ E+ KKI+ + E +++K 
Sbjct: 208 QRMREE---KREERRRREIERKRQREEERRKWKEEEKRKRKDIEKLKKIDRIPERDKLKD 264

Query: 156 TKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRN 215
              ++  +   +   ++  +++ EK  +KE   +E+ KK+  ++L+   AS       + 
Sbjct: 265 EPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKREKAKKLDKENLSDERASGQSCTLPKR 324

Query: 216 SENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPTALRESQVAEEEEWLHKQAEARRAMNT 275
           S++    +LK++    P            R +     + ++  E E L +Q E RR    
Sbjct: 325 SDS----ELKDEKPKRPEDESGRDYREREREYER--DQERILRERERLKRQEEERRRQKE 378

Query: 276 --DIAELCDLKEEE--KNPEWLKDKGNKLFATEN 305
             +  +    KEEE  K  + L+DKG K  +TE+
Sbjct: 379 RYEKEKTFKRKEEEMKKEKDTLRDKGKKAESTES 412



 Score = 37.4 bits (85), Expect = 0.023
 Identities = 31/140 (22%), Positives = 64/140 (45%), Gaps = 12/140 (8%)

Query: 91  VDKEMMQRIREKSILQAQERAKEAT-EAKAAAKREDQKY-------ALSVMMKIEEEERK 142
           V + ++Q + +K++L+  E+  E   + +  AK+ D++          S  +    +   
Sbjct: 270 VHRFLLQAVNQKNLLKKPEKGDEKELDKREKAKKLDKENLSDERASGQSCTLPKRSDSEL 329

Query: 143 KIEDMKENERIKATKALEAWKEYQRKAE----EQKKIQREEKLCQKEKQIKEERKKIKYK 198
           K E  K  E        E  +EY+R  E    E+++++R+E+  +++K+  E+ K  K K
Sbjct: 330 KDEKPKRPEDESGRDYREREREYERDQERILRERERLKRQEEERRRQKERYEKEKTFKRK 389

Query: 199 SLTRNLASRNLAPKGRNSEN 218
                     L  KG+ +E+
Sbjct: 390 EEEMKKEKDTLRDKGKKAES 409



 Score = 36.2 bits (82), Expect = 0.050
 Identities = 30/125 (24%), Positives = 55/125 (44%), Gaps = 6/125 (4%)

Query: 94  EMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENERI 153
           E  +R  ++S    +ER +E    +    RE ++      +K +EEER++ ++  E E+ 
Sbjct: 332 EKPKRPEDESGRDYREREREYERDQERILRERER------LKRQEEERRRQKERYEKEKT 385

Query: 154 KATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAPKG 213
              K  E  KE     ++ KK +  E +   EK  K+E    + +   ++  +  L   G
Sbjct: 386 FKRKEEEMKKEKDTLRDKGKKAESTESIGSSEKTEKKEEVVKRDRIRNKDRPAMQLYQPG 445

Query: 214 RNSEN 218
             S N
Sbjct: 446 ARSRN 450



 Score = 30.0 bits (66), Expect = 3.6
 Identities = 27/104 (25%), Positives = 51/104 (49%), Gaps = 8/104 (7%)

Query: 124 EDQKYALSVMMKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQREEKLCQ 183
           +++K   +    +EE E K  E + +    K T  L   K  QR  EE+++ +R  ++ +
Sbjct: 170 DNEKMTSTPETLLEEIEAKNRELIAK----KTTPLLSFLKNKQRMREEKREERRRREI-E 224

Query: 184 KEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKED 227
           +++Q +EER+K K +   +      L    R  E    +KLK++
Sbjct: 225 RKRQREEERRKWKEEEKRKRKDIEKLKKIDRIPER---DKLKDE 265


>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
           [Homo sapiens]
          Length = 914

 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 62/281 (22%), Positives = 124/281 (44%), Gaps = 17/281 (6%)

Query: 70  TIVFTLYKKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYA 129
           T + T+ + +  M  T +   V K  ++R    + L+   + KE    +   ++E+ +  
Sbjct: 494 TFLHTVQRNQMLMTPTSAPRSVMKSFIKR---NTPLRMDPKEKERQRLENLRRKEEAEQL 550

Query: 130 LSVMMKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIK 189
                K+EE++R+++E++K     +  K L+A     R+  EQ K ++++++ QK  QI 
Sbjct: 551 RR--QKVEEDKRRRLEEVKLKREERLRKVLQA-----RERVEQMKEEKKKQIEQKFAQID 603

Query: 190 EERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPT 249
           E+ +K K + L    A +  A K    E +   + +E+     R +  ++     R    
Sbjct: 604 EKTEKAKEERLAEEKAKKKAAAK--KMEEVEARRKQEEE---ARRLRWLQQEEEERRHQE 658

Query: 250 ALRESQVAEEEEWLHKQAEARRAMNTDIAELCDLKEEEKNPEWLKDKGNKLFATENYLAA 309
            L++ +  EE+E L K AEA+R       E  + +  E+     + +  +    E  LA 
Sbjct: 659 LLQKKK-EEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAE 717

Query: 310 INAYNLAIRLNNKMPLLYLNRAACHLKLKNLHKAIEDSSKE 350
                   RL  +  L    + A  L+ + L + +E+  K+
Sbjct: 718 QERRREQERLQAERELQEREK-ALRLQKEQLQRELEEKKKK 757



 Score = 46.6 bits (109), Expect = 4e-05
 Identities = 50/230 (21%), Positives = 106/230 (46%), Gaps = 44/230 (19%)

Query: 54  YAPIDDESSKAKIGNDTIVFTLYKKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKE 113
           +A ID+++ KAK   + +     KK+AA               +++ E    + QE  +E
Sbjct: 599 FAQIDEKTEKAK--EERLAEEKAKKKAAA--------------KKMEEVEARRKQE--EE 640

Query: 114 ATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQK 173
           A   +   + E+++    ++ K +EEE++++    E +R+   +  E  ++ +R+ E ++
Sbjct: 641 ARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERRE 700

Query: 174 KIQREEKLCQKEKQIKEERKKIKYKSL--TRNLASRNLA---PKGRNSENIFTEKLKEDS 228
           + +RE++  ++E+Q+ E+ ++ + + L   R L  R  A    K +    +  +K KE+ 
Sbjct: 701 QERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQ 760

Query: 229 IPAPRSVGSIKINFTPRVFPTALRESQVAEEEEWLHKQAE-ARRAMNTDI 277
                                 L E Q+ EE+E   K+A  A +A+N  +
Sbjct: 761 --------------------QRLAERQLQEEQEKKAKEAAGASKALNVTV 790


>gi|120953300 leucine-rich repeats and IQ motif containing 1 isoform
           1 [Homo sapiens]
          Length = 1722

 Score = 53.5 bits (127), Expect = 3e-07
 Identities = 54/223 (24%), Positives = 99/223 (44%), Gaps = 26/223 (11%)

Query: 97  QRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIE--------DMK 148
           Q   + S+L+ Q  A    +AK  A    QKY   +  +IE ++RK  E          K
Sbjct: 272 QEKEKNSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQK 331

Query: 149 ENERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKI--KYKSLTRNLAS 206
           E E  K  +  +  KE ++K +E+++ +RE++  +K+  +K+ER+++  K K + R  AS
Sbjct: 332 EEENRKRLEEEQRIKEERKKQKEEERKRREKEYEEKKNIVKQEREQLISKEKIILREDAS 391

Query: 207 RN------LAPKGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPTALRESQVAEEE 260
           +       L   G N++++  E +  D     +++          V    + ES + E  
Sbjct: 392 QQLIISSALKKSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVLLWLVEESNMKEN- 450

Query: 261 EWLHKQAEARRAMNTDIAE-------LCDLKEEEKNPEWLKDK 296
             + +Q   + ++   + E       L D K EEKN    K +
Sbjct: 451 --VDRQTILKESIQVKLKESISSQTILADFKMEEKNENLAKKR 491



 Score = 37.7 bits (86), Expect = 0.017
 Identities = 48/203 (23%), Positives = 91/203 (44%), Gaps = 34/203 (16%)

Query: 92  DKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENE 151
           +K+     +EK  L+AQ   +E    K   + E++++      K+E   +KK+E++++ E
Sbjct: 176 EKQKELEDKEKQTLKAQRDREE----KQFQEEEEKRHCWMKQFKVE---KKKLENIQKQE 228

Query: 152 RIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAP 211
           + K     E +KE   K  ++K  Q EE +     Q++EER + K           +   
Sbjct: 229 QDKMND--ELYKE--EKIWKEKFKQHEEYIRNLHLQMEEERTRFK-----------DQQE 273

Query: 212 KGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPTALR---ESQVAEEEEWLHKQAE 268
           K +NS       LK+ +  A +     K     + +   ++   ES+  + +EW  K+A+
Sbjct: 274 KEKNS------LLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAK 327

Query: 269 ARRAMNTD---IAELCDLKEEEK 288
            R+    +   + E   +KEE K
Sbjct: 328 IRQKEEENRKRLEEEQRIKEERK 350



 Score = 33.5 bits (75), Expect = 0.33
 Identities = 14/41 (34%), Positives = 28/41 (68%)

Query: 154 KATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKK 194
           K  ++ EAW+E Q++ E+++K   + +  ++EKQ +EE +K
Sbjct: 166 KCRQSFEAWQEKQKELEDKEKQTLKAQRDREEKQFQEEEEK 206



 Score = 30.0 bits (66), Expect = 3.6
 Identities = 39/202 (19%), Positives = 81/202 (40%), Gaps = 8/202 (3%)

Query: 117 AKAAAKREDQKYALSVMMKIEEEERKKIED----MKENERIKATKALEAWKEYQRKAEEQ 172
           AK       +K    ++  +EE   K+  D    +KE+ ++K  +++ +         E+
Sbjct: 423 AKNLVDENSKKQEDVLLWLVEESNMKENVDRQTILKESIQVKLKESISSQTILADFKMEE 482

Query: 173 KKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAP 232
           K     +K C +E  +K+ERK   Y++        N   KG   E    ++LK D+    
Sbjct: 483 KNENLAKKRCSEEL-VKQERK---YENTDNKTELGNSDLKGNLKEQFPLQELKSDAQKEE 538

Query: 233 RSVGSIKINFTPRVFPTALRESQVAEEEEWLHKQAEARRAMNTDIAELCDLKEEEKNPEW 292
           + +  +    T +     L  +Q   E +   +Q   +      I ++   + +E+N   
Sbjct: 539 KIMKHVINENTGQKTQIILGHNQEISEVKTNEEQKIIKDNQQKKIQKVEKEEIQEQNGLL 598

Query: 293 LKDKGNKLFATENYLAAINAYN 314
            KDK   + + +    ++ + N
Sbjct: 599 YKDKDTLVISVKQRSLSLTSEN 620


>gi|120953243 leucine-rich repeats and IQ motif containing 1 isoform
           2 [Homo sapiens]
          Length = 1336

 Score = 53.5 bits (127), Expect = 3e-07
 Identities = 54/223 (24%), Positives = 99/223 (44%), Gaps = 26/223 (11%)

Query: 97  QRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIE--------DMK 148
           Q   + S+L+ Q  A    +AK  A    QKY   +  +IE ++RK  E          K
Sbjct: 272 QEKEKNSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQK 331

Query: 149 ENERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKI--KYKSLTRNLAS 206
           E E  K  +  +  KE ++K +E+++ +RE++  +K+  +K+ER+++  K K + R  AS
Sbjct: 332 EEENRKRLEEEQRIKEERKKQKEEERKRREKEYEEKKNIVKQEREQLISKEKIILREDAS 391

Query: 207 RN------LAPKGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPTALRESQVAEEE 260
           +       L   G N++++  E +  D     +++          V    + ES + E  
Sbjct: 392 QQLIISSALKKSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVLLWLVEESNMKEN- 450

Query: 261 EWLHKQAEARRAMNTDIAE-------LCDLKEEEKNPEWLKDK 296
             + +Q   + ++   + E       L D K EEKN    K +
Sbjct: 451 --VDRQTILKESIQVKLKESISSQTILADFKMEEKNENLAKKR 491



 Score = 37.7 bits (86), Expect = 0.017
 Identities = 48/203 (23%), Positives = 91/203 (44%), Gaps = 34/203 (16%)

Query: 92  DKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENE 151
           +K+     +EK  L+AQ   +E    K   + E++++      K+E   +KK+E++++ E
Sbjct: 176 EKQKELEDKEKQTLKAQRDREE----KQFQEEEEKRHCWMKQFKVE---KKKLENIQKQE 228

Query: 152 RIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAP 211
           + K     E +KE   K  ++K  Q EE +     Q++EER + K           +   
Sbjct: 229 QDKMND--ELYKE--EKIWKEKFKQHEEYIRNLHLQMEEERTRFK-----------DQQE 273

Query: 212 KGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPTALR---ESQVAEEEEWLHKQAE 268
           K +NS       LK+ +  A +     K     + +   ++   ES+  + +EW  K+A+
Sbjct: 274 KEKNS------LLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAK 327

Query: 269 ARRAMNTD---IAELCDLKEEEK 288
            R+    +   + E   +KEE K
Sbjct: 328 IRQKEEENRKRLEEEQRIKEERK 350



 Score = 33.5 bits (75), Expect = 0.33
 Identities = 14/41 (34%), Positives = 28/41 (68%)

Query: 154 KATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKK 194
           K  ++ EAW+E Q++ E+++K   + +  ++EKQ +EE +K
Sbjct: 166 KCRQSFEAWQEKQKELEDKEKQTLKAQRDREEKQFQEEEEK 206



 Score = 30.0 bits (66), Expect = 3.6
 Identities = 39/202 (19%), Positives = 81/202 (40%), Gaps = 8/202 (3%)

Query: 117 AKAAAKREDQKYALSVMMKIEEEERKKIED----MKENERIKATKALEAWKEYQRKAEEQ 172
           AK       +K    ++  +EE   K+  D    +KE+ ++K  +++ +         E+
Sbjct: 423 AKNLVDENSKKQEDVLLWLVEESNMKENVDRQTILKESIQVKLKESISSQTILADFKMEE 482

Query: 173 KKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAP 232
           K     +K C +E  +K+ERK   Y++        N   KG   E    ++LK D+    
Sbjct: 483 KNENLAKKRCSEEL-VKQERK---YENTDNKTELGNSDLKGNLKEQFPLQELKSDAQKEE 538

Query: 233 RSVGSIKINFTPRVFPTALRESQVAEEEEWLHKQAEARRAMNTDIAELCDLKEEEKNPEW 292
           + +  +    T +     L  +Q   E +   +Q   +      I ++   + +E+N   
Sbjct: 539 KIMKHVINENTGQKTQIILGHNQEISEVKTNEEQKIIKDNQQKKIQKVEKEEIQEQNGLL 598

Query: 293 LKDKGNKLFATENYLAAINAYN 314
            KDK   + + +    ++ + N
Sbjct: 599 YKDKDTLVISVKQRSLSLTSEN 620


>gi|94538370 DnaJ (Hsp40) homolog, subfamily C, member 2 isoform 1
           [Homo sapiens]
          Length = 621

 Score = 52.8 bits (125), Expect = 5e-07
 Identities = 83/348 (23%), Positives = 143/348 (41%), Gaps = 52/348 (14%)

Query: 6   SDYSWQQTKTAVFLSLPLKGVCVRDTD-VFCTENYLKVNFPPFLFEAFLYAPIDDESSK- 63
           +DY    TK    LS P+K       D  F      K       FE F   P+ + +S+ 
Sbjct: 135 NDYFTCITKAYEMLSDPVKRRAFNSVDPTFDNSVPSKSEAKDNFFEVF--TPVFERNSRW 192

Query: 64  ------AKIGN------DTIVFTLYKKEAAMWETLS-VTGVDKEMMQRIREKSILQAQER 110
                  K+G+      D  +F  +      W   S +   +KE  +   E+  ++ Q R
Sbjct: 193 SNKKNVPKLGDMNSSFEDVDIFYSFWYNFDSWREFSYLDEEEKEKAECRDERRWIEKQNR 252

Query: 111 AKEATEAKAAAKR----EDQKYALSVMMKIEEEERKKIEDMKENERIKATKALEAWKEYQ 166
           A  A   K    R     D  Y+    +K  +EE K  ++ ++  + +A +  +  KE Q
Sbjct: 253 ATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEEKAKKEAEKKAKAEAKRKEQEAKEKQ 312

Query: 167 RKAE----------EQKKIQREEKLCQKEKQI-----KEERKKIKYKSLTRNLASRNLAP 211
           R+AE          E+++++++  L +KEK I     K+ER+K++    T N  S N A 
Sbjct: 313 RQAELEAARLAKEKEEEEVRQQALLAKKEKDIQKKAIKKERQKLRNSCKTWNHFSDNEAE 372

Query: 212 KGRNSENIFTEKLKED-SIPAPRSVGSIKINFTPRVFPTALRESQVAEEEEWLHKQAEAR 270
           + +  E +  EKL +   + + + +     + T  V   AL E Q+ E  E + K+ E  
Sbjct: 373 RVKMMEEV--EKLCDRLELASLQCLNETLTSCTKEVGKAAL-EKQIEEINEQIRKEKEEA 429

Query: 271 RAMNTDIAELCDLKEEEKNPEWLK---DKGNKLFATENYLAAINAYNL 315
            A          +++  KN E        G+K ++ ++    I A NL
Sbjct: 430 EAR---------MRQASKNTEKSTGGGGNGSKNWSEDDLQLLIKAVNL 468


>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo
           sapiens]
          Length = 1293

 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 45/206 (21%), Positives = 99/206 (48%), Gaps = 20/206 (9%)

Query: 81  AMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAKREDQ---------KYALS 131
           ++W+    T      ++++++    +A +  +E  EA+  AKRE++         +    
Sbjct: 702 SVWDLPLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEE 761

Query: 132 VMMKIEEEERKKIEDMKENERIKATKALEAWKEYQ----RKAEEQKKIQREEKLCQKEKQ 187
           ++ + +EEERK+ E+ +E  R K  +AL   +E +    R+ EE+++ Q+EE L + E++
Sbjct: 762 ILRRQQEEERKRREE-EELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEER 820

Query: 188 IKEERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVF 247
            +EE ++ K + L R       A K    E     +L+E+ +        ++     R  
Sbjct: 821 RREEEERRKQEELLRK--QEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEER-- 876

Query: 248 PTALRESQVAEEEEWLHKQAEARRAM 273
               +E +V  ++E + ++ + + A+
Sbjct: 877 --KRKELEVQRQKELMRQRQQQQEAL 900



 Score = 48.1 bits (113), Expect = 1e-05
 Identities = 48/192 (25%), Positives = 83/192 (43%), Gaps = 34/192 (17%)

Query: 107 AQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMK-------ENERIKATKAL 159
           A E+ ++  +AKAA K E ++    +  K EEEERK+ E+++         ++ +  K  
Sbjct: 716 ALEQLQQLEKAKAA-KLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRR 774

Query: 160 EAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSENI 219
           E  +  +RK EE  + QRE+++  + ++ +EER+  + +   R L  R    + R  +  
Sbjct: 775 EEEELARRKQEEALRRQREQEIALRRQREEEERQ--QQEEALRRLEERRREEEERRKQEE 832

Query: 220 FTEKLKEDSIPAPRSVGSIKINFTPRVFPTALRESQVAEEEEWLHKQAEARRAMNTDIAE 279
              K +E++    R                        EEEE   +  E R  M  + A 
Sbjct: 833 LLRKQEEEAAKWAR------------------------EEEEAQRRLEENRLRMEEEAAR 868

Query: 280 LCDLKEEEKNPE 291
           L   +EE K  E
Sbjct: 869 LRHEEEERKRKE 880



 Score = 46.2 bits (108), Expect = 5e-05
 Identities = 44/186 (23%), Positives = 89/186 (47%), Gaps = 7/186 (3%)

Query: 92  DKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVM--MKIEEEERKKIEDMKE 149
           ++E+ +R +E+++ + +E+       +   +R+ Q+ AL  +   + EEEER+K E++  
Sbjct: 776 EEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLR 835

Query: 150 NERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKI---KYKSLTRNLAS 206
            +  +A K     +E QR+ EE +    EE    + ++ + +RK++   + K L R    
Sbjct: 836 KQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQ 895

Query: 207 RNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPT-ALRESQVAEEEEWLHK 265
           +  A + R  +    ++L +  +P+  + G        +   T +L E Q  EEE     
Sbjct: 896 QQEALR-RLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQL 954

Query: 266 QAEARR 271
           + E RR
Sbjct: 955 REEQRR 960


>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo
           sapiens]
          Length = 1320

 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 45/206 (21%), Positives = 99/206 (48%), Gaps = 20/206 (9%)

Query: 81  AMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAKREDQ---------KYALS 131
           ++W+    T      ++++++    +A +  +E  EA+  AKRE++         +    
Sbjct: 729 SVWDLPLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEE 788

Query: 132 VMMKIEEEERKKIEDMKENERIKATKALEAWKEYQ----RKAEEQKKIQREEKLCQKEKQ 187
           ++ + +EEERK+ E+ +E  R K  +AL   +E +    R+ EE+++ Q+EE L + E++
Sbjct: 789 ILRRQQEEERKRREE-EELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEER 847

Query: 188 IKEERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVF 247
            +EE ++ K + L R       A K    E     +L+E+ +        ++     R  
Sbjct: 848 RREEEERRKQEELLRK--QEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEER-- 903

Query: 248 PTALRESQVAEEEEWLHKQAEARRAM 273
               +E +V  ++E + ++ + + A+
Sbjct: 904 --KRKELEVQRQKELMRQRQQQQEAL 927



 Score = 48.1 bits (113), Expect = 1e-05
 Identities = 48/192 (25%), Positives = 83/192 (43%), Gaps = 34/192 (17%)

Query: 107 AQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMK-------ENERIKATKAL 159
           A E+ ++  +AKAA K E ++    +  K EEEERK+ E+++         ++ +  K  
Sbjct: 743 ALEQLQQLEKAKAA-KLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRR 801

Query: 160 EAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSENI 219
           E  +  +RK EE  + QRE+++  + ++ +EER+  + +   R L  R    + R  +  
Sbjct: 802 EEEELARRKQEEALRRQREQEIALRRQREEEERQ--QQEEALRRLEERRREEEERRKQEE 859

Query: 220 FTEKLKEDSIPAPRSVGSIKINFTPRVFPTALRESQVAEEEEWLHKQAEARRAMNTDIAE 279
              K +E++    R                        EEEE   +  E R  M  + A 
Sbjct: 860 LLRKQEEEAAKWAR------------------------EEEEAQRRLEENRLRMEEEAAR 895

Query: 280 LCDLKEEEKNPE 291
           L   +EE K  E
Sbjct: 896 LRHEEEERKRKE 907



 Score = 46.2 bits (108), Expect = 5e-05
 Identities = 44/186 (23%), Positives = 89/186 (47%), Gaps = 7/186 (3%)

Query: 92  DKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVM--MKIEEEERKKIEDMKE 149
           ++E+ +R +E+++ + +E+       +   +R+ Q+ AL  +   + EEEER+K E++  
Sbjct: 803 EEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLR 862

Query: 150 NERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKI---KYKSLTRNLAS 206
            +  +A K     +E QR+ EE +    EE    + ++ + +RK++   + K L R    
Sbjct: 863 KQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQ 922

Query: 207 RNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPT-ALRESQVAEEEEWLHK 265
           +  A + R  +    ++L +  +P+  + G        +   T +L E Q  EEE     
Sbjct: 923 QQEALR-RLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQL 981

Query: 266 QAEARR 271
           + E RR
Sbjct: 982 REEQRR 987


>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo
           sapiens]
          Length = 1299

 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 45/206 (21%), Positives = 99/206 (48%), Gaps = 20/206 (9%)

Query: 81  AMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAKREDQ---------KYALS 131
           ++W+    T      ++++++    +A +  +E  EA+  AKRE++         +    
Sbjct: 708 SVWDLPLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEE 767

Query: 132 VMMKIEEEERKKIEDMKENERIKATKALEAWKEYQ----RKAEEQKKIQREEKLCQKEKQ 187
           ++ + +EEERK+ E+ +E  R K  +AL   +E +    R+ EE+++ Q+EE L + E++
Sbjct: 768 ILRRQQEEERKRREE-EELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEER 826

Query: 188 IKEERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVF 247
            +EE ++ K + L R       A K    E     +L+E+ +        ++     R  
Sbjct: 827 RREEEERRKQEELLRK--QEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEER-- 882

Query: 248 PTALRESQVAEEEEWLHKQAEARRAM 273
               +E +V  ++E + ++ + + A+
Sbjct: 883 --KRKELEVQRQKELMRQRQQQQEAL 906



 Score = 48.1 bits (113), Expect = 1e-05
 Identities = 48/192 (25%), Positives = 83/192 (43%), Gaps = 34/192 (17%)

Query: 107 AQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMK-------ENERIKATKAL 159
           A E+ ++  +AKAA K E ++    +  K EEEERK+ E+++         ++ +  K  
Sbjct: 722 ALEQLQQLEKAKAA-KLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRR 780

Query: 160 EAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSENI 219
           E  +  +RK EE  + QRE+++  + ++ +EER+  + +   R L  R    + R  +  
Sbjct: 781 EEEELARRKQEEALRRQREQEIALRRQREEEERQ--QQEEALRRLEERRREEEERRKQEE 838

Query: 220 FTEKLKEDSIPAPRSVGSIKINFTPRVFPTALRESQVAEEEEWLHKQAEARRAMNTDIAE 279
              K +E++    R                        EEEE   +  E R  M  + A 
Sbjct: 839 LLRKQEEEAAKWAR------------------------EEEEAQRRLEENRLRMEEEAAR 874

Query: 280 LCDLKEEEKNPE 291
           L   +EE K  E
Sbjct: 875 LRHEEEERKRKE 886



 Score = 46.2 bits (108), Expect = 5e-05
 Identities = 44/186 (23%), Positives = 89/186 (47%), Gaps = 7/186 (3%)

Query: 92  DKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVM--MKIEEEERKKIEDMKE 149
           ++E+ +R +E+++ + +E+       +   +R+ Q+ AL  +   + EEEER+K E++  
Sbjct: 782 EEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLR 841

Query: 150 NERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKI---KYKSLTRNLAS 206
            +  +A K     +E QR+ EE +    EE    + ++ + +RK++   + K L R    
Sbjct: 842 KQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQ 901

Query: 207 RNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPT-ALRESQVAEEEEWLHK 265
           +  A + R  +    ++L +  +P+  + G        +   T +L E Q  EEE     
Sbjct: 902 QQEALR-RLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQL 960

Query: 266 QAEARR 271
           + E RR
Sbjct: 961 REEQRR 966


>gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo
           sapiens]
          Length = 1299

 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 45/206 (21%), Positives = 99/206 (48%), Gaps = 20/206 (9%)

Query: 81  AMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAKREDQ---------KYALS 131
           ++W+    T      ++++++    +A +  +E  EA+  AKRE++         +    
Sbjct: 708 SVWDLPLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEE 767

Query: 132 VMMKIEEEERKKIEDMKENERIKATKALEAWKEYQ----RKAEEQKKIQREEKLCQKEKQ 187
           ++ + +EEERK+ E+ +E  R K  +AL   +E +    R+ EE+++ Q+EE L + E++
Sbjct: 768 ILRRQQEEERKRREE-EELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEER 826

Query: 188 IKEERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVF 247
            +EE ++ K + L R       A K    E     +L+E+ +        ++     R  
Sbjct: 827 RREEEERRKQEELLRK--QEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEER-- 882

Query: 248 PTALRESQVAEEEEWLHKQAEARRAM 273
               +E +V  ++E + ++ + + A+
Sbjct: 883 --KRKELEVQRQKELMRQRQQQQEAL 906



 Score = 48.1 bits (113), Expect = 1e-05
 Identities = 48/192 (25%), Positives = 83/192 (43%), Gaps = 34/192 (17%)

Query: 107 AQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMK-------ENERIKATKAL 159
           A E+ ++  +AKAA K E ++    +  K EEEERK+ E+++         ++ +  K  
Sbjct: 722 ALEQLQQLEKAKAA-KLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRR 780

Query: 160 EAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSENI 219
           E  +  +RK EE  + QRE+++  + ++ +EER+  + +   R L  R    + R  +  
Sbjct: 781 EEEELARRKQEEALRRQREQEIALRRQREEEERQ--QQEEALRRLEERRREEEERRKQEE 838

Query: 220 FTEKLKEDSIPAPRSVGSIKINFTPRVFPTALRESQVAEEEEWLHKQAEARRAMNTDIAE 279
              K +E++    R                        EEEE   +  E R  M  + A 
Sbjct: 839 LLRKQEEEAAKWAR------------------------EEEEAQRRLEENRLRMEEEAAR 874

Query: 280 LCDLKEEEKNPE 291
           L   +EE K  E
Sbjct: 875 LRHEEEERKRKE 886



 Score = 46.2 bits (108), Expect = 5e-05
 Identities = 44/186 (23%), Positives = 89/186 (47%), Gaps = 7/186 (3%)

Query: 92  DKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVM--MKIEEEERKKIEDMKE 149
           ++E+ +R +E+++ + +E+       +   +R+ Q+ AL  +   + EEEER+K E++  
Sbjct: 782 EEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLR 841

Query: 150 NERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKI---KYKSLTRNLAS 206
            +  +A K     +E QR+ EE +    EE    + ++ + +RK++   + K L R    
Sbjct: 842 KQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQ 901

Query: 207 RNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPT-ALRESQVAEEEEWLHK 265
           +  A + R  +    ++L +  +P+  + G        +   T +L E Q  EEE     
Sbjct: 902 QQEALR-RLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQL 960

Query: 266 QAEARR 271
           + E RR
Sbjct: 961 REEQRR 966


>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 750

 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 54/232 (23%), Positives = 103/232 (44%), Gaps = 32/232 (13%)

Query: 77  KKEAAMWETLSVTGVDKEMM------QRIREKSILQAQERAKEATEAKAAAKREDQKYAL 130
           ++E  MWE        +EMM       R +E+ + + +E+ +E  E     K  +Q+   
Sbjct: 353 RQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEE-----KMHEQEKIR 407

Query: 131 SVMMKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQ-KKIQREEKLCQKEKQIK 189
               K +EEE+ + ++ ++ +  K  +  E  +E + K  EQ KK+ R+E+   ++++I+
Sbjct: 408 EQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIR 467

Query: 190 EERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPT 249
           EE K+ + + + R         K    E I+ +K K             K+         
Sbjct: 468 EEEKRQEQEEMWRQ------EEKIHEQEEIWRQKEKMHEQEEKIRKQEEKV--------- 512

Query: 250 ALRESQVAEEEEWLHKQAEARRAMNTDIAELCDL-KEEEKNPE----WLKDK 296
             +E ++ E+EE + +Q E        I E  ++ +EEEK  E    W ++K
Sbjct: 513 WRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEK 564



 Score = 46.6 bits (109), Expect = 4e-05
 Identities = 45/208 (21%), Positives = 104/208 (50%), Gaps = 21/208 (10%)

Query: 93  KEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKI-EEEERKKIEDM--KE 149
           +E  ++IRE+   +   R +E    +    RE++K  +    KI EEE+R++ ED   ++
Sbjct: 520 REQEEKIREQE--EKMWRQEEKIREQEEMWREEEK--MHEQEKIWEEEKRQEQEDKMWRQ 575

Query: 150 NERIKATKALEAWKEYQR-KAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRN 208
            E+I+  +  + W++ ++ + +E+K+ ++EEK+ ++E++I+E+ +KI+ +          
Sbjct: 576 EEKIREQEE-KVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQE--------- 625

Query: 209 LAPKGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPTALRESQVAEEEEWLHKQAE 268
              K R  E    E+ +E +      +G  +     +      +E  +  +EE + +Q +
Sbjct: 626 --EKIREQEEKIREQ-EEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEK 682

Query: 269 ARRAMNTDIAELCDLKEEEKNPEWLKDK 296
             R     I E  ++ +E++   W +++
Sbjct: 683 KIREQEEKIREQEEMMQEQEEKMWEQEE 710



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 46/188 (24%), Positives = 81/188 (43%), Gaps = 20/188 (10%)

Query: 93  KEMMQRIREKSI-LQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENE 151
           +E  ++IRE+   ++ QE      E     K E  +    +M + EE+ R++ E M E E
Sbjct: 317 QEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKE 376

Query: 152 RIKATKALEAW------KEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLA 205
                +    W      +E + K  EQ+KI+ +E+  Q+E++I+E+ K+ + +       
Sbjct: 377 EKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQE------- 429

Query: 206 SRNLAPKGRNSENI--FTEKLKEDSIPAPRSVGSIKINFTPRVFPTALRESQVAEEEEWL 263
               A   R  E I    EK++E      R    I      R       + ++  +EE +
Sbjct: 430 ----AKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKI 485

Query: 264 HKQAEARR 271
           H+Q E  R
Sbjct: 486 HEQEEIWR 493



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 29/108 (26%), Positives = 57/108 (52%), Gaps = 13/108 (12%)

Query: 93  KEMMQRIRE-KSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEE---EERKKIEDMK 148
           +E  ++IRE + + Q QE      E K   + E  +     M + EE   E+ KKI + +
Sbjct: 629 REQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQE 688

Query: 149 ENERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIK 196
           E  R          +E   + +E+K  ++EEK+C++E++++E+ +K++
Sbjct: 689 EKIR---------EQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMR 727



 Score = 43.1 bits (100), Expect = 4e-04
 Identities = 42/211 (19%), Positives = 96/211 (45%), Gaps = 10/211 (4%)

Query: 93  KEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENER 152
           +E  +++R +  +  ++  K   + +   ++E++      MM  +EE+ ++ E+M   + 
Sbjct: 331 REQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKE 390

Query: 153 IKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASR---NL 209
            K  +  E   E ++  E+++K Q EEK+ ++EK+ ++E K  + +   R    +     
Sbjct: 391 EKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQE 450

Query: 210 APKGRNSENIF-TEKLKEDSIPAPRSV---GSIKINFTPRVFPTALRESQVAEEEEWLHK 265
               R  E I   EK++E+     +        KI+    ++    ++ ++ E+EE + K
Sbjct: 451 KKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIW---RQKEKMHEQEEKIRK 507

Query: 266 QAEARRAMNTDIAELCDLKEEEKNPEWLKDK 296
           Q E        I E  +   E++   W +++
Sbjct: 508 QEEKVWRQEEKIREQEEKIREQEEKMWRQEE 538



 Score = 42.4 bits (98), Expect = 7e-04
 Identities = 37/207 (17%), Positives = 94/207 (45%), Gaps = 21/207 (10%)

Query: 97  QRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENERIKAT 156
           ++I E+  +  Q+      E K   K+E++ +     ++ +EE+ ++ E+    +  K  
Sbjct: 483 EKIHEQEEIWRQKEKMHEQEEKIR-KQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIR 541

Query: 157 KALEAWKEYQRKAE------EQKKIQREEKLCQKEKQIKEERKKI-KYKSLTRNLASRNL 209
           +  E W+E ++  E      E+K+ ++E+K+ ++E++I+E+ +K+ + +   R    +  
Sbjct: 542 EQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQ 601

Query: 210 APKGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPTALRESQVAEEEEWLHKQAEA 269
             + +  +    EK++E           I+            +E ++ E+EE   +Q E 
Sbjct: 602 EQEEKMWKQ--EEKIREQEEKIQEQEEKIR-----------EQEEKIREQEEMTQEQEEK 648

Query: 270 RRAMNTDIAELCDLKEEEKNPEWLKDK 296
                  + E  +  +E++   W +++
Sbjct: 649 MGEQEEKMCEQEEKMQEQEETMWRQEE 675



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 29/125 (23%), Positives = 64/125 (51%), Gaps = 6/125 (4%)

Query: 77  KKEAAMWETLSVTGVDKEMMQRIREKSILQAQ---ERAKEATEAKAAAKREDQKYALSVM 133
           ++E  +W         +E  Q   EK   Q +   E+ ++  E +   + +++K      
Sbjct: 581 EQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEE 640

Query: 134 MKIEEEER--KKIEDMKENERIKATKALEAWKEYQRKAEEQKKI-QREEKLCQKEKQIKE 190
           M  E+EE+  ++ E M E E     +    W++ ++  E++KKI ++EEK+ ++E+ ++E
Sbjct: 641 MTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQE 700

Query: 191 ERKKI 195
           + +K+
Sbjct: 701 QEEKM 705



 Score = 39.3 bits (90), Expect = 0.006
 Identities = 30/132 (22%), Positives = 68/132 (51%), Gaps = 25/132 (18%)

Query: 77  KKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKI 136
           ++E  MW         +E   R +E+ + + +E+ +E  E     KR++Q+  +    + 
Sbjct: 567 EQEDKMWR--------QEEKIREQEEKVWRQEEKIREQEE-----KRQEQEEKMWKQEEK 613

Query: 137 EEEERKKIEDMKEN-----ERIKATKALEAWKEYQRKAEEQKKIQREEK-------LCQK 184
             E+ +KI++ +E      E+I+  + +   +E +   +E+K  ++EEK       + ++
Sbjct: 614 IREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQ 673

Query: 185 EKQIKEERKKIK 196
           E++I+E+ KKI+
Sbjct: 674 EEKIREQEKKIR 685



 Score = 38.1 bits (87), Expect = 0.013
 Identities = 29/126 (23%), Positives = 63/126 (50%), Gaps = 10/126 (7%)

Query: 75  LYKKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAKRED----QKYAL 130
           L +K A + E L +   +K  +Q +  K + +  ERAK     +      D    +  ++
Sbjct: 219 LKEKNAKLQEKLQLVESEKSEIQ-LNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSV 277

Query: 131 SVMMKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKE 190
           S  ++ + EE +    + + +  K  +  E  +E++ K +EQ     EEK+ ++E++I+E
Sbjct: 278 SAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQ-----EEKIREQEEKIRE 332

Query: 191 ERKKIK 196
           + +K++
Sbjct: 333 QEEKMR 338


>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 899

 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 40/152 (26%), Positives = 74/152 (48%), Gaps = 14/152 (9%)

Query: 75  LYKKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMM 134
           + ++E  MWE        +E M R  E+  L  QE+     E K   + E        M 
Sbjct: 350 MQEQEEKMWEQEEKMREQEEKMWRQEER--LWEQEKQMREQEQKMRDQEER-------MW 400

Query: 135 KIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKK 194
           + +E  R+K E M+E E  K  + +E  +E ++  E++KK + +E+  Q+E++I+E  KK
Sbjct: 401 EQDERLREKEERMREQE--KMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKK 458

Query: 195 IKYKSLTRNLASRNLAPKGRNSENIFTEKLKE 226
           ++ +  T       +    +  EN++ ++ KE
Sbjct: 459 MREEEETMREQEEKMQ---KQEENMWEQEEKE 487



 Score = 50.1 bits (118), Expect = 3e-06
 Identities = 43/212 (20%), Positives = 94/212 (44%), Gaps = 38/212 (17%)

Query: 93  KEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENER 152
           +E  + +RE+  L+ QE   +  E K   + E  +     M + EE   ++ + M+E E+
Sbjct: 331 REQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQ 390

Query: 153 IKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAPK 212
               +    W++ +R  E++++++ +EK+ ++ ++++EE+K  + +  TR+         
Sbjct: 391 KMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQ-------- 442

Query: 213 GRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPTALRESQVAEEEEWLHKQAEARRA 272
                    EK++E+                        RE ++ EEEE + +Q E    
Sbjct: 443 --------EEKMQEEE-------------------RIREREKKMREEEETMREQEE---K 472

Query: 273 MNTDIAELCDLKEEEKNPEWLKDKGNKLFATE 304
           M      + + +E+E   + L ++  KL+  E
Sbjct: 473 MQKQEENMWEQEEKEWQQQRLPEQKEKLWEQE 504



 Score = 46.6 bits (109), Expect = 4e-05
 Identities = 43/222 (19%), Positives = 94/222 (42%), Gaps = 2/222 (0%)

Query: 77  KKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKI 136
           ++E  MWE        ++ M    E+   + QE+ K+  + +   + E++       M+ 
Sbjct: 541 EQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMRE 600

Query: 137 EEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQ--KKIQREEKLCQKEKQIKEERKK 194
           EEE  ++ E+  + +  K  +  E   E + K +EQ  K  ++EEK+ ++E+++ E+++ 
Sbjct: 601 EEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRL 660

Query: 195 IKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPTALRES 254
            + K             K +  E    E+ K +     +   +              RE 
Sbjct: 661 PEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREK 720

Query: 255 QVAEEEEWLHKQAEARRAMNTDIAELCDLKEEEKNPEWLKDK 296
           ++ EEEE + +Q E  +     + E  +   E++   W +++
Sbjct: 721 KMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEE 762



 Score = 46.2 bits (108), Expect = 5e-05
 Identities = 34/128 (26%), Positives = 63/128 (49%), Gaps = 10/128 (7%)

Query: 78  KEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIE 137
           +E  MWE       +KE   R +EK   Q ++  +E    +   K  DQ+  +    +I 
Sbjct: 395 QEERMWEQDERLR-EKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIR 453

Query: 138 EEERKKIED---MKENERIKATKALEAWKE------YQRKAEEQKKIQREEKLCQKEKQI 188
           E E+K  E+   M+E E     +    W++       QR  E+++K+  +EK+ ++E++I
Sbjct: 454 EREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKI 513

Query: 189 KEERKKIK 196
            E+ +KI+
Sbjct: 514 WEQEEKIR 521



 Score = 45.4 bits (106), Expect = 8e-05
 Identities = 30/122 (24%), Positives = 65/122 (53%), Gaps = 10/122 (8%)

Query: 75  LYKKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMM 134
           + ++E  MWE        +E MQ   EK   Q ++  ++  +     +  +QK  L    
Sbjct: 619 MQEQEEKMWE-------QEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHE 671

Query: 135 KIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKK 194
           K++E+E+ + ++ K  E+ K  K  +   E ++K  +Q+K++ EE + ++EK+++EE + 
Sbjct: 672 KMQEQEKMQEQEEKIWEQEKMEKKTQ---EQEKKTWDQEKMREEESMREREKKMREEEEM 728

Query: 195 IK 196
           ++
Sbjct: 729 MR 730



 Score = 42.7 bits (99), Expect = 5e-04
 Identities = 35/148 (23%), Positives = 73/148 (49%), Gaps = 5/148 (3%)

Query: 75  LYKKEAAMWETLSVTGVDK--EMMQRI--REKSILQAQERAKEATEAKAAAKREDQKYAL 130
           L +++  +WE   +   +K  E  ++I  +EK   + QE+ K+  + +   + E  +   
Sbjct: 660 LPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMRERE 719

Query: 131 SVMMKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQREEKLC-QKEKQIK 189
             M + EE  R++ E M+E E     +  E W++ ++  E+++K+  +++L  QKEK  +
Sbjct: 720 KKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWE 779

Query: 190 EERKKIKYKSLTRNLASRNLAPKGRNSE 217
            E+ + + K   +    R+   K R  E
Sbjct: 780 HEKMQEQEKIWEQEEKMRDQEEKMRGQE 807



 Score = 42.4 bits (98), Expect = 7e-04
 Identities = 25/108 (23%), Positives = 63/108 (58%), Gaps = 4/108 (3%)

Query: 93  KEMMQRIREKSILQAQERAKEATEAKAAAKR-EDQKYALSVMMK--IEEEERKKIEDMKE 149
           K+    ++EK  L   E+++     K   ++ E  K+ L  +    ++EE  ++ E+++E
Sbjct: 224 KKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELRE 283

Query: 150 NERIKATKALEAWKEYQRKAEEQKKI-QREEKLCQKEKQIKEERKKIK 196
            E+    +  + W++ +R  E++ K+ ++EEK+ ++EK+++E+ K+++
Sbjct: 284 QEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELR 331



 Score = 42.4 bits (98), Expect = 7e-04
 Identities = 26/125 (20%), Positives = 68/125 (54%), Gaps = 7/125 (5%)

Query: 75  LYKKEAAMWETLSVTGVDK---EMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALS 131
           L +++  +WE   +   ++   E  ++IR++  +  QE  K+    +   ++EDQ +   
Sbjct: 493 LPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQE--KKMWRQEKMREQEDQMWEQE 550

Query: 132 VMMKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEE 191
             M+ +E++    E+  E +  +  K  + W + ++  EE++  +RE+K+ ++E+ ++E+
Sbjct: 551 EKMRDQEQKMWDQEERMEKKTQEQEK--KTWDQEEKMREEERMREREKKMREEEEMMREQ 608

Query: 192 RKKIK 196
            +K++
Sbjct: 609 EEKMQ 613



 Score = 40.8 bits (94), Expect = 0.002
 Identities = 31/120 (25%), Positives = 67/120 (55%), Gaps = 11/120 (9%)

Query: 77  KKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAK--REDQKYALSVMM 134
           +++  MWE +     +K+M ++  EK     +E+ +E    +   K  RE+++     M 
Sbjct: 414 REQEKMWEQVEKMREEKKMQEQ--EKKTRDQEEKMQEEERIREREKKMREEEE----TMR 467

Query: 135 KIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQ-REEKLCQKEKQIKEERK 193
           + EE+ +K+ E+M E E  +  +  +   E + K  EQ+K+Q +EEK+ ++E++I+++ +
Sbjct: 468 EQEEKMQKQEENMWEQEEKEWQQ--QRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEE 525



 Score = 39.7 bits (91), Expect = 0.005
 Identities = 43/222 (19%), Positives = 104/222 (46%), Gaps = 15/222 (6%)

Query: 75  LYKKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMM 134
           L KK A + E L +   +K  +Q +  K + +  ERAK           +++ +     +
Sbjct: 223 LKKKNAELQEKLPLAESEKSEIQ-LNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEEL 281

Query: 135 KIEEEERKKIEDM--KENERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEER 192
           + +E++ +K E+   ++ ER++        +E + + +E+K  ++E++L ++EK+++E+ 
Sbjct: 282 REQEKKIRKQEEKMWRQEERLRE-------QEGKMREQEEKMWRQEKRLREQEKELREQE 334

Query: 193 KKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAPRSVGSI---KINFTPRVFPT 249
           K+++ +   R    +    + +  E    EK++E      R    +   +     +    
Sbjct: 335 KELREQKELREQEEQMQEQEEKMWEQ--EEKMREQEEKMWRQEERLWEQEKQMREQEQKM 392

Query: 250 ALRESQVAEEEEWLHKQAEARRAMNTDIAELCDLKEEEKNPE 291
             +E ++ E++E L ++ E  R       ++  ++EE+K  E
Sbjct: 393 RDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQE 434



 Score = 35.4 bits (80), Expect = 0.086
 Identities = 27/123 (21%), Positives = 66/123 (53%), Gaps = 12/123 (9%)

Query: 77  KKEAAMWETLSVTGVDKEMMQRIREKSILQA---QERAKEATEAKAAAKREDQKYALSVM 133
           ++E +M E       ++EMM+   EK   Q    QE+ +E  E +     +++K      
Sbjct: 710 REEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQR 769

Query: 134 MKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQ-REEKLCQKEKQIKEER 192
           +  ++E+  + E M+E E+I        W++ ++  ++++K++ +EEK+  +E++++ + 
Sbjct: 770 LPEQKEKLWEHEKMQEQEKI--------WEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQE 821

Query: 193 KKI 195
           +K+
Sbjct: 822 EKM 824



 Score = 34.3 bits (77), Expect = 0.19
 Identities = 40/172 (23%), Positives = 77/172 (44%), Gaps = 25/172 (14%)

Query: 74  TLYKKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAKRE--------- 124
           ++ ++E  M E   +    +E MQ   EK  +Q QE      E K   + E         
Sbjct: 714 SMREREKKMREEEEMMREQEEKMQEQEEK--MQEQEEEMWEQEEKMWEQEEKMWEQQRLP 771

Query: 125 DQKYALSVMMKIEEEER-----KKIEDMKEN-----ERIKATKALEAWKEYQRKAEEQKK 174
           +QK  L    K++E+E+     +K+ D +E      E+++  +     +E +   +E+K 
Sbjct: 772 EQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKM 831

Query: 175 IQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKE 226
             +EEK+  +E+++  + +K++ K   +    R    K R  E    EK++E
Sbjct: 832 WGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQE----EKMRE 879



 Score = 34.3 bits (77), Expect = 0.19
 Identities = 26/129 (20%), Positives = 62/129 (48%), Gaps = 7/129 (5%)

Query: 75  LYKKEAAMWETLSVTGVDKEMMQ--RIREKSILQAQERAKEATEAKAAAKREDQKYALSV 132
           ++++E  MWE   +    +++ +  +++E+  +  QE      E K   + E  +     
Sbjct: 757 MWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEK 816

Query: 133 MMKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAE-----EQKKIQREEKLCQKEKQ 187
           M   EE+   + E M   E     +  + W + ++  E     E+K  ++EEK+  +E++
Sbjct: 817 MRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEK 876

Query: 188 IKEERKKIK 196
           ++E+ +K++
Sbjct: 877 MREQEEKMR 885



 Score = 32.0 bits (71), Expect = 0.95
 Identities = 24/123 (19%), Positives = 62/123 (50%), Gaps = 3/123 (2%)

Query: 75  LYKKEAAMWETLSVTGVDK--EMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSV 132
           L +++  +WE   +   +K  E  +++R++      +  K   + +    +E++ +    
Sbjct: 770 LPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEE 829

Query: 133 MMKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEER 192
            M  +EE+    E+    +  K  + ++  +E  R+ EE+ + Q EEK+ ++E++++ + 
Sbjct: 830 KMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQ-EEKMREQEEKMRGQE 888

Query: 193 KKI 195
           +KI
Sbjct: 889 EKI 891


>gi|116686122 kinesin family member 4 [Homo sapiens]
          Length = 1232

 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 53/223 (23%), Positives = 99/223 (44%), Gaps = 30/223 (13%)

Query: 96  MQRIREKSILQAQERAKEATEAKAAAKREDQKYAL--------------SVMMKIEEEER 141
           +Q+ +E+ +L+ Q   K+A +AK + +R  +   L              S ++K++E   
Sbjct: 571 LQKEKEELVLELQTAKKDANQAKLSERRRKRLQELEGQIADLKKKLNEQSKLLKLKESTE 630

Query: 142 KKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYK--S 199
           + +   K N+ I+  K        Q K + +K  Q ++K  ++  Q+KE  +K +Y+   
Sbjct: 631 RTVS--KLNQEIRMMKNQRVQLMRQMKEDAEKFRQWKQKKDKEVIQLKERDRKRQYELLK 688

Query: 200 LTRNLASRNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPR-VFPTALR------ 252
           L RN   ++   + +  E     K  +D++   R V   +     R +  TA R      
Sbjct: 689 LERNFQKQSNVLRRKTEEAAAANKRLKDALQKQREVADKRKETQSRGMEGTAARVKNWLG 748

Query: 253 ---ESQVAEEE--EWLHKQAEARRAMNTDIAELCDLKEEEKNP 290
              E  V+ EE    L+   E R+ +  D+A+L + KE  +NP
Sbjct: 749 NEIEVMVSTEEAKRHLNDLLEDRKILAQDVAQLKEKKESGENP 791



 Score = 29.6 bits (65), Expect = 4.7
 Identities = 22/97 (22%), Positives = 51/97 (52%), Gaps = 4/97 (4%)

Query: 111  AKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAE 170
            A+  TE +A   R +Q++   V+  + + ++ ++ + K+ E   + K  +     + + E
Sbjct: 910  AEIETELQAELVRMEQQHQEKVLYLLSQLQQSQMAE-KQLEESVSEKEQQLLSTLKCQDE 968

Query: 171  EQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASR 207
            E +K++   ++C++ +Q+  E + IK K     +ASR
Sbjct: 969  ELEKMR---EVCEQNQQLLRENEIIKQKLTLLQVASR 1002


>gi|88759339 aster-associated protein [Homo sapiens]
          Length = 647

 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 40/156 (25%), Positives = 75/156 (48%), Gaps = 5/156 (3%)

Query: 75  LYKKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMM 134
           L KK   + E   +  ++ E ++   E+     +E A  + EA  A K ++ K  ++   
Sbjct: 433 LEKKNVYLHEMHRIKRIESENLRIQNEQKKAAKREEALASFEAWKAMKEKEAK-KIAAKK 491

Query: 135 KIEEEERKKIEDMKENERIKATKALEAWKEYQR---KAEEQKKIQREEKLCQKEKQIKEE 191
           ++EE+ +KK E+     + +A +A E WKE +    K + +K+ + E    QKE++   E
Sbjct: 492 RLEEKNKKKTEEENAARKGEALQAFEKWKEKKMEYLKEKNRKEREYERAKKQKEEETVAE 551

Query: 192 RKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKED 227
           +KK    ++ +    +    K +  E I  EK KE+
Sbjct: 552 KKKDNLTAVEKWNEKKEAFFKQKEKEKI-NEKRKEE 586



 Score = 40.8 bits (94), Expect = 0.002
 Identities = 44/185 (23%), Positives = 85/185 (45%), Gaps = 28/185 (15%)

Query: 60  ESSKAKIGNDTIVFTLYKKEAAMWETLSVTGVDKEMMQRIREKSILQA--QERAKEATEA 117
           ES   +I N+       KK A   E L+     K M ++  +K   +   +E+ K+ TE 
Sbjct: 450 ESENLRIQNEQ------KKAAKREEALASFEAWKAMKEKEAKKIAAKKRLEEKNKKKTEE 503

Query: 118 KAAAKRED-----QKYALSVMMKIEEEERKKIE-----DMKENERIKATK-----ALEAW 162
           + AA++ +     +K+    M  ++E+ RK+ E       KE E +   K     A+E W
Sbjct: 504 ENAARKGEALQAFEKWKEKKMEYLKEKNRKEREYERAKKQKEEETVAEKKKDNLTAVEKW 563

Query: 163 KE-----YQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSE 217
            E     +++K +E+   +R+E+L + EK+ K+++   +Y+    N   +    + +   
Sbjct: 564 NEKKEAFFKQKEKEKINEKRKEELKRAEKKDKDKQAINEYEKWLENKEKQERIERKQKKR 623

Query: 218 NIFTE 222
           + F E
Sbjct: 624 HSFLE 628



 Score = 40.8 bits (94), Expect = 0.002
 Identities = 38/133 (28%), Positives = 66/133 (49%), Gaps = 11/133 (8%)

Query: 93  KEMMQRIREKSILQAQ-ERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENE 151
           ++ M+ ++EK+  + + ERAK+  E +  A+++        +  +E+   KK    K+ E
Sbjct: 521 EKKMEYLKEKNRKEREYERAKKQKEEETVAEKKKDN-----LTAVEKWNEKKEAFFKQKE 575

Query: 152 RIKAT-KALEAWKEYQRKAEEQKKIQREEK-LCQKEKQIKEERKKIKYKSLTRNLASRNL 209
           + K   K  E  K  ++K ++++ I   EK L  KEKQ + ERK+ K  S    L S  L
Sbjct: 576 KEKINEKRKEELKRAEKKDKDKQAINEYEKWLENKEKQERIERKQKKRHSF---LESEAL 632

Query: 210 APKGRNSENIFTE 222
            P    S  +F +
Sbjct: 633 PPWSPPSRTVFAK 645


>gi|5803181 stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing
           protein) [Homo sapiens]
          Length = 543

 Score = 50.1 bits (118), Expect = 3e-06
 Identities = 50/167 (29%), Positives = 79/167 (47%), Gaps = 30/167 (17%)

Query: 180 KLCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIK 239
           +LC+K  ++  E ++  Y+ + +  A        R   + F E+  +D+I       S+ 
Sbjct: 280 ELCEKAIEVGRENRE-DYRQIAKAYA--------RIGNSYFKEEKYKDAIHFYNK--SLA 328

Query: 240 INFTPRVFPTALRESQVAEEEEWLHKQAEARRAMNTDIAELCDLKEEEKNPEWLKDKGNK 299
            + TP V    L++ Q AE+   + K+ E    +N D+A       EEKN      KGN+
Sbjct: 329 EHRTPDV----LKKCQQAEK---ILKEQERLAYINPDLAL------EEKN------KGNE 369

Query: 300 LFATENYLAAINAYNLAIRLNNKMPLLYLNRAACHLKLKNLHKAIED 346
            F   +Y  A+  Y  AI+ N K   LY NRAAC+ KL     A++D
Sbjct: 370 CFQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLEFQLALKD 416



 Score = 43.1 bits (100), Expect = 4e-04
 Identities = 23/57 (40%), Positives = 33/57 (57%)

Query: 293 LKDKGNKLFATENYLAAINAYNLAIRLNNKMPLLYLNRAACHLKLKNLHKAIEDSSK 349
           LK+KGNK  +  N   A+  Y+ AI+L+    +LY NR+A + K  +  KA ED  K
Sbjct: 7   LKEKGNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYEDGCK 63


>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
           sapiens]
          Length = 570

 Score = 50.1 bits (118), Expect = 3e-06
 Identities = 47/217 (21%), Positives = 99/217 (45%), Gaps = 16/217 (7%)

Query: 77  KKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKI 136
           ++E  MW         +E +Q   EK  ++ QE      E     K E  +    +M + 
Sbjct: 285 QQEEKMWRQEEKIQEREEKIQEQEEK--IREQEEKMRRQEEMMWEKEEKMRRQEEMMWEK 342

Query: 137 EEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIK 196
           EE+ R+  E M E E+I+  +  E  +E ++  E++K+ ++E K+ ++E++I+E+ +KI+
Sbjct: 343 EEKIRELEEKMHEQEKIREQE--EKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIR 400

Query: 197 YKSLTRNLASRNLAPKGRNSENIF--TEKLKEDSIPAPRSVGSIKINFTPRVFPTALRES 254
            +     +        G   E ++   E+++E      R    I+     +      +E 
Sbjct: 401 EQ---EEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIR----EQEKKIREQEE 453

Query: 255 QVAEEEEWLHKQAEARRAMNTDIAELCDLKEEEKNPE 291
           ++ E+EE + +Q E    M     ++C+ + + +  E
Sbjct: 454 KIREQEEMMQEQEE---KMGEQEGKMCEQEAKMQEQE 487



 Score = 46.2 bits (108), Expect = 5e-05
 Identities = 36/129 (27%), Positives = 69/129 (53%), Gaps = 12/129 (9%)

Query: 77  KKEAAMWETLSVTGVDKEMMQRIRE-KSILQAQERAKEATEAKAAAKREDQKYALSVMMK 135
           ++EA MW         +E  ++IRE + ++Q QE      E K   + E+ +     M +
Sbjct: 380 EQEAKMWRQEEKI---REQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRR 436

Query: 136 IEE---EERKKI----EDMKENERIKATKALEAWKEYQRKAEEQKKIQ-REEKLCQKEKQ 187
            EE   E+ KKI    E ++E E +   +  +  ++  +  E++ K+Q +EEK+ ++E++
Sbjct: 437 QEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEK 496

Query: 188 IKEERKKIK 196
           I+E+ KKI+
Sbjct: 497 IREQEKKIR 505



 Score = 46.2 bits (108), Expect = 5e-05
 Identities = 33/133 (24%), Positives = 73/133 (54%), Gaps = 13/133 (9%)

Query: 77  KKEAAMWETLSVTGVDKEMMQRI------REKSILQAQERAKEATEA--KAAAKREDQKY 128
           ++E  MWE        +E M+R       +EK I + +E+ +E  E   +   K  +Q+ 
Sbjct: 415 EQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEG 474

Query: 129 AL----SVMMKIEEEERKKIEDMKENER-IKATKALEAWKEYQRKAEEQKKIQREEKLCQ 183
            +    + M + EE+ R++ E ++E E+ I+  +     +E   + +E+K  ++EEK+C+
Sbjct: 475 KMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCE 534

Query: 184 KEKQIKEERKKIK 196
           +E++++E+ +K++
Sbjct: 535 QEEKMQEQEEKMR 547



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 26/105 (24%), Positives = 61/105 (58%), Gaps = 3/105 (2%)

Query: 93  KEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENER 152
           +EMMQ   EK  +  QE      EAK   + E  +     + + E++ R++ E ++E E 
Sbjct: 459 EEMMQEQEEK--MGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEE 516

Query: 153 IKATKALEAWKEYQRKAEEQKKIQ-REEKLCQKEKQIKEERKKIK 196
           +   +  + W++ ++  E+++K+Q +EEK+ ++E++++E+  +++
Sbjct: 517 MMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLR 561



 Score = 37.7 bits (86), Expect = 0.017
 Identities = 45/212 (21%), Positives = 93/212 (43%), Gaps = 20/212 (9%)

Query: 78  KEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIE 137
           +E  +W  L+     +E M R  EK     QER ++  E +   + +++K     M + E
Sbjct: 274 EENELWNRLNQQ--QEEKMWRQEEK----IQEREEKIQEQEEKIREQEEK-----MRRQE 322

Query: 138 EEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQREEKLC-QKEKQIKEERKKIK 196
           E   +K E M+  E +        W++ ++  E ++K+  +EK+  Q+EK+ +EE+ + +
Sbjct: 323 EMMWEKEEKMRRQEEMM-------WEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQ 375

Query: 197 YKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPTALRESQV 256
            K   +         K R  E    E+ +E        +G  +     +      +E ++
Sbjct: 376 EKRQEQEAKMWRQEEKIREQEEKIREQ-EEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKM 434

Query: 257 AEEEEWLHKQAEARRAMNTDIAELCDLKEEEK 288
             +EE + +Q +  R     I E  ++ +E++
Sbjct: 435 RRQEEKIREQEKKIREQEEKIREQEEMMQEQE 466



 Score = 36.2 bits (82), Expect = 0.050
 Identities = 42/206 (20%), Positives = 91/206 (44%), Gaps = 13/206 (6%)

Query: 75  LYKKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAKRED----QKYAL 130
           L +K A + E L +   +K  +Q +  K + +  ERAK     +      D    +  ++
Sbjct: 207 LKEKNAKLQEKLQLVESEKSEIQ-LNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSV 265

Query: 131 SVMMKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKI--QREEKLCQKEKQI 188
           S  ++ + EE +    + + +  K  +  E  +E + K +EQ++   ++EEK+ ++E+ +
Sbjct: 266 SAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMM 325

Query: 189 KEERKKIKYKS---LTRNLASRNLAPKGRNSENIFTEKLK---EDSIPAPRSVGSIKINF 242
            E+ +K++ +      +    R L  K    E I  ++ K   E+ I         +   
Sbjct: 326 WEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKM 385

Query: 243 TPRVFPTALRESQVAEEEEWLHKQAE 268
             +      +E ++ E+EE + +Q E
Sbjct: 386 WRQEEKIREQEEKIREQEEMMQEQEE 411


>gi|4506921 small glutamine-rich tetratricopeptide [Homo sapiens]
          Length = 313

 Score = 50.1 bits (118), Expect = 3e-06
 Identities = 25/69 (36%), Positives = 38/69 (55%)

Query: 284 KEEEKNPEWLKDKGNKLFATENYLAAINAYNLAIRLNNKMPLLYLNRAACHLKLKNLHKA 343
           +E+    E LK +GN+    EN+ AA++ Y  AI LN    + + NRAA + KL N   A
Sbjct: 85  EEDSAEAERLKTEGNEQMKVENFEAAVHFYGKAIELNPANAVYFCNRAAAYSKLGNYAGA 144

Query: 344 IEDSSKEFC 352
           ++D  +  C
Sbjct: 145 VQDCERAIC 153


>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
           [Homo sapiens]
          Length = 918

 Score = 50.1 bits (118), Expect = 3e-06
 Identities = 63/284 (22%), Positives = 125/284 (44%), Gaps = 19/284 (6%)

Query: 70  TIVFTLYKKEAAMWETLSVTGVDKEMMQR---IREKSILQAQERAKEATEAKAAAKREDQ 126
           T + T+ + +  M  T +   V K  ++R   +R        E+ ++  E     +R+++
Sbjct: 494 TFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLEN---LRRKEE 550

Query: 127 KYALSVMMKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEK 186
              L    K+EE++R+++E++K     +  K L+A     R+  EQ K ++++++ QK  
Sbjct: 551 AEQLR-RQKVEEDKRRRLEEVKLKREERLRKVLQA-----RERVEQMKEEKKKQIEQKFA 604

Query: 187 QIKEERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRV 246
           QI E+ +K K + L    A +  A K    E +   + +E+     R +  ++     R 
Sbjct: 605 QIDEKTEKAKEERLAEEKAKKKAAAK--KMEEVEARRKQEEE---ARRLRWLQQEEEERR 659

Query: 247 FPTALRESQVAEEEEWLHKQAEARRAMNTDIAELCDLKEEEKNPEWLKDKGNKLFATENY 306
               L++ +  EE+E L K AEA+R       E  + +  E+     + +  +    E  
Sbjct: 660 HQELLQKKK-EEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQ 718

Query: 307 LAAINAYNLAIRLNNKMPLLYLNRAACHLKLKNLHKAIEDSSKE 350
           LA         RL  +  L    + A  L+ + L + +E+  K+
Sbjct: 719 LAEQERRREQERLQAERELQEREK-ALRLQKEQLQRELEEKKKK 761



 Score = 46.6 bits (109), Expect = 4e-05
 Identities = 50/230 (21%), Positives = 106/230 (46%), Gaps = 44/230 (19%)

Query: 54  YAPIDDESSKAKIGNDTIVFTLYKKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKE 113
           +A ID+++ KAK   + +     KK+AA               +++ E    + QE  +E
Sbjct: 603 FAQIDEKTEKAK--EERLAEEKAKKKAAA--------------KKMEEVEARRKQE--EE 644

Query: 114 ATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQK 173
           A   +   + E+++    ++ K +EEE++++    E +R+   +  E  ++ +R+ E ++
Sbjct: 645 ARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERRE 704

Query: 174 KIQREEKLCQKEKQIKEERKKIKYKSL--TRNLASRNLA---PKGRNSENIFTEKLKEDS 228
           + +RE++  ++E+Q+ E+ ++ + + L   R L  R  A    K +    +  +K KE+ 
Sbjct: 705 QERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQ 764

Query: 229 IPAPRSVGSIKINFTPRVFPTALRESQVAEEEEWLHKQAE-ARRAMNTDI 277
                                 L E Q+ EE+E   K+A  A +A+N  +
Sbjct: 765 --------------------QRLAERQLQEEQEKKAKEAAGASKALNVTV 794


>gi|12711674 UPF3 regulator of nonsense transcripts homolog B
           isoform 2 [Homo sapiens]
          Length = 470

 Score = 50.1 bits (118), Expect = 3e-06
 Identities = 54/213 (25%), Positives = 97/213 (45%), Gaps = 25/213 (11%)

Query: 97  QRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENERIKAT 156
           QR+RE+   + +ER +   E K   + E +K+      + E+ +RK IE +K+ +RI   
Sbjct: 208 QRMREE---KREERRRREIERKRQREEERRKWK-----EEEKRKRKDIEKLKKIDRIPER 259

Query: 157 KALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNS 216
             L       +   + K +++ EK  +KE   +E+ KK+  ++L+   AS       + S
Sbjct: 260 DKL-------KDEPKIKLLKKPEKGDEKELDKREKAKKLDKENLSDERASGQSCTLPKRS 312

Query: 217 ENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPTALRESQVAEEEEWLHKQAEARRAMNT- 275
           ++    +LK++    P            R +     + ++  E E L +Q E RR     
Sbjct: 313 DS----ELKDEKPKRPEDESGRDYREREREYER--DQERILRERERLKRQEEERRRQKER 366

Query: 276 -DIAELCDLKEEE--KNPEWLKDKGNKLFATEN 305
            +  +    KEEE  K  + L+DKG K  +TE+
Sbjct: 367 YEKEKTFKRKEEEMKKEKDTLRDKGKKAESTES 399



 Score = 36.2 bits (82), Expect = 0.050
 Identities = 30/125 (24%), Positives = 55/125 (44%), Gaps = 6/125 (4%)

Query: 94  EMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENERI 153
           E  +R  ++S    +ER +E    +    RE ++      +K +EEER++ ++  E E+ 
Sbjct: 319 EKPKRPEDESGRDYREREREYERDQERILRERER------LKRQEEERRRQKERYEKEKT 372

Query: 154 KATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAPKG 213
              K  E  KE     ++ KK +  E +   EK  K+E    + +   ++  +  L   G
Sbjct: 373 FKRKEEEMKKEKDTLRDKGKKAESTESIGSSEKTEKKEEVVKRDRIRNKDRPAMQLYQPG 432

Query: 214 RNSEN 218
             S N
Sbjct: 433 ARSRN 437



 Score = 35.0 bits (79), Expect = 0.11
 Identities = 29/130 (22%), Positives = 65/130 (50%), Gaps = 11/130 (8%)

Query: 90  GVDKEMMQRIREKSILQAQERAKEAT-EAKAAAKREDQKYALSVMMKIEEEERKKIEDMK 148
           G +KE+ +R + K + +     + A+ ++    KR D +        +++E+ K+ ED  
Sbjct: 277 GDEKELDKREKAKKLDKENLSDERASGQSCTLPKRSDSE--------LKDEKPKRPED-- 326

Query: 149 ENERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRN 208
           E+ R    +  E  ++ +R   E+++++R+E+  +++K+  E+ K  K K          
Sbjct: 327 ESGRDYREREREYERDQERILRERERLKRQEEERRRQKERYEKEKTFKRKEEEMKKEKDT 386

Query: 209 LAPKGRNSEN 218
           L  KG+ +E+
Sbjct: 387 LRDKGKKAES 396


>gi|27262638 sperm associated antigen 1 [Homo sapiens]
          Length = 926

 Score = 50.1 bits (118), Expect = 3e-06
 Identities = 24/71 (33%), Positives = 42/71 (59%)

Query: 286 EEKNPEWLKDKGNKLFATENYLAAINAYNLAIRLNNKMPLLYLNRAACHLKLKNLHKAIE 345
           +EK  + LK++GN+    +NY  A++ Y+  +++NNK   +Y NRA C+LKL    +A +
Sbjct: 619 DEKTFKALKEEGNQCVNDKNYKDALSKYSECLKINNKECAIYTNRALCYLKLCQFEEAKQ 678

Query: 346 DSSKEFCSLEG 356
           D  +     +G
Sbjct: 679 DCDQALQLADG 689



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 25/70 (35%), Positives = 38/70 (54%), Gaps = 8/70 (11%)

Query: 288 KNPEWLKDKGNKLFATENYLAAINAYNLAIRL--------NNKMPLLYLNRAACHLKLKN 339
           +NP  LK +GN+LF +  +  A   Y+ AI L         + + +LY NRAAC+LK  N
Sbjct: 443 ENPAGLKSQGNELFRSGQFAEAAGKYSAAIALLEPAGSEIADDLSILYSNRAACYLKEGN 502

Query: 340 LHKAIEDSSK 349
               I+D ++
Sbjct: 503 CSGCIQDCNR 512



 Score = 38.9 bits (89), Expect = 0.008
 Identities = 50/192 (26%), Positives = 83/192 (43%), Gaps = 24/192 (12%)

Query: 169 AEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDS 228
           AEE +KI  + K    E + KEE K   +++ T      NL P   ++  +   K K   
Sbjct: 89  AEEWEKIDGDIKSWVSEIK-KEEDKMHFHETETFPAMKDNLPPVRGSNSCLHVGKEKYSK 147

Query: 229 IPAPRSVGSIKINFTPR---------VFPTALRESQVAEEEEWLHKQAEARRAMNTDIAE 279
            P  +         TPR         V    L+  +  +E+  + K   ++     D A 
Sbjct: 148 RPTKKK--------TPRDYAEWDKFDVEKECLKIDEDYKEKTVIDKSHLSKIETRIDTAG 199

Query: 280 LCDLKEEEKNPEWLKDKGNKLFATENYLAAINAYNLAIRLNNKMPLL--YLNRAACHLKL 337
           L + KE++      K+KGN+ F + +Y  A+  Y  +I   + +P +  Y NRA   +KL
Sbjct: 200 LTE-KEKDFLATREKEKGNEAFNSGDYEEAVMYYTRSI---SALPTVVAYNNRAQAEIKL 255

Query: 338 KNLHKAIEDSSK 349
           +N + A +D  K
Sbjct: 256 QNWNSAFQDCEK 267


>gi|27262636 sperm associated antigen 1 [Homo sapiens]
          Length = 926

 Score = 50.1 bits (118), Expect = 3e-06
 Identities = 24/71 (33%), Positives = 42/71 (59%)

Query: 286 EEKNPEWLKDKGNKLFATENYLAAINAYNLAIRLNNKMPLLYLNRAACHLKLKNLHKAIE 345
           +EK  + LK++GN+    +NY  A++ Y+  +++NNK   +Y NRA C+LKL    +A +
Sbjct: 619 DEKTFKALKEEGNQCVNDKNYKDALSKYSECLKINNKECAIYTNRALCYLKLCQFEEAKQ 678

Query: 346 DSSKEFCSLEG 356
           D  +     +G
Sbjct: 679 DCDQALQLADG 689



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 25/70 (35%), Positives = 38/70 (54%), Gaps = 8/70 (11%)

Query: 288 KNPEWLKDKGNKLFATENYLAAINAYNLAIRL--------NNKMPLLYLNRAACHLKLKN 339
           +NP  LK +GN+LF +  +  A   Y+ AI L         + + +LY NRAAC+LK  N
Sbjct: 443 ENPAGLKSQGNELFRSGQFAEAAGKYSAAIALLEPAGSEIADDLSILYSNRAACYLKEGN 502

Query: 340 LHKAIEDSSK 349
               I+D ++
Sbjct: 503 CSGCIQDCNR 512



 Score = 38.9 bits (89), Expect = 0.008
 Identities = 50/192 (26%), Positives = 83/192 (43%), Gaps = 24/192 (12%)

Query: 169 AEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDS 228
           AEE +KI  + K    E + KEE K   +++ T      NL P   ++  +   K K   
Sbjct: 89  AEEWEKIDGDIKSWVSEIK-KEEDKMHFHETETFPAMKDNLPPVRGSNSCLHVGKEKYSK 147

Query: 229 IPAPRSVGSIKINFTPR---------VFPTALRESQVAEEEEWLHKQAEARRAMNTDIAE 279
            P  +         TPR         V    L+  +  +E+  + K   ++     D A 
Sbjct: 148 RPTKKK--------TPRDYAEWDKFDVEKECLKIDEDYKEKTVIDKSHLSKIETRIDTAG 199

Query: 280 LCDLKEEEKNPEWLKDKGNKLFATENYLAAINAYNLAIRLNNKMPLL--YLNRAACHLKL 337
           L + KE++      K+KGN+ F + +Y  A+  Y  +I   + +P +  Y NRA   +KL
Sbjct: 200 LTE-KEKDFLATREKEKGNEAFNSGDYEEAVMYYTRSI---SALPTVVAYNNRAQAEIKL 255

Query: 338 KNLHKAIEDSSK 349
           +N + A +D  K
Sbjct: 256 QNWNSAFQDCEK 267


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 49.3 bits (116), Expect = 6e-06
 Identities = 51/222 (22%), Positives = 103/222 (46%), Gaps = 16/222 (7%)

Query: 92   DKEMMQRIREKSILQAQERAKEATEAKAAAKRE--DQKYALSVMMKIEEEERKKIEDMKE 149
            ++E + + RE+  L  QER ++  E +   +R+  D+K+     ++ +E ERK +E+ ++
Sbjct: 1465 EEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFR-EQELRSQEPERKFLEEEQQ 1523

Query: 150  NERI-KATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRN 208
              R  +  K L+  ++ +R+   Q++ Q  ++  ++E+Q+++ER++ +     R+   R 
Sbjct: 1524 LHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRL 1583

Query: 209  LAPKGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPTALRESQ---VAEEEEWLHK 265
               K R  E     K  ED     R  G  ++    +      RE +      EE+ LH+
Sbjct: 1584 EEQKVRRQEQ--ERKFMEDEQQLRRQEGQQQLR---QERDRKFREDEQLLQEREEQQLHR 1638

Query: 266  QAEARRAMNTDIAELCDLKEEEKNPEWLKDKGNKLFATENYL 307
            Q   R+ +     E   L+ +E+  +   D+  K    E  L
Sbjct: 1639 QERDRKFLE----EEPQLRRQEREQQLRHDRDRKFREEEQLL 1676



 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 38/182 (20%), Positives = 89/182 (48%), Gaps = 11/182 (6%)

Query: 92  DKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENE 151
           +K+  +R R+  + Q +E  KE  + +   ++E++K         EEE +++ E  +E E
Sbjct: 225 EKQQQRRERQDRVFQEEEE-KEWRKRETVLRKEEEKLQ-------EEEPQRQRELQEEEE 276

Query: 152 RIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTR--NLASRNL 209
           +++  +  E  +E Q + ++Q++++RE++L +K+++ + E+++ + +   R      R  
Sbjct: 277 QLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERRE 336

Query: 210 APKGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPTALRESQVAEEEEWLHKQAEA 269
               R  E    ++L+ +     R     +     R      RE Q+  E++ L ++ + 
Sbjct: 337 QQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQ-LRREQQL 395

Query: 270 RR 271
           RR
Sbjct: 396 RR 397



 Score = 46.6 bits (109), Expect = 4e-05
 Identities = 44/232 (18%), Positives = 101/232 (43%), Gaps = 7/232 (3%)

Query: 93  KEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENER 152
           ++  +  RE+ +   +E  +E  E +    R +Q+      +K +EEE +  + ++  ++
Sbjct: 478 RDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQ 537

Query: 153 IKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAPK 212
           ++  +  E  +E   K EE+K++++E    ++E+++K E+++ + + L R    R    K
Sbjct: 538 LR--REQEERREQLLKREEEKRLEQE----RREQRLKREQEERRDQLLKREEERRQQRLK 591

Query: 213 GRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPTALRESQVAEEEEWLHKQAEARRA 272
            R  E    ++LK + +         +            R+  +  EE+   +Q + RR 
Sbjct: 592 -REQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRRE 650

Query: 273 MNTDIAELCDLKEEEKNPEWLKDKGNKLFATENYLAAINAYNLAIRLNNKMP 324
                 +    +EEE+  E    + ++    E  LA         R+ +++P
Sbjct: 651 QQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIP 702



 Score = 45.8 bits (107), Expect = 6e-05
 Identities = 53/239 (22%), Positives = 98/239 (41%), Gaps = 37/239 (15%)

Query: 74   TLYKKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVM 133
            TLY K A   +      + KE      E+  LQ +ER K   + +    RE+++      
Sbjct: 888  TLYAKPALQEQ------LRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEE 941

Query: 134  MKIEEEERKKIEDMKENE-------RIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEK 186
              + EE  K+    +E +       + K  + L    E +R+ E +KK + EE+L Q+E+
Sbjct: 942  QLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEE 1001

Query: 187  Q-IKEERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPR 245
            Q ++EER+K + +   R    ++     +  E +  E+ ++  +                
Sbjct: 1002 QLLREEREKRRRQEWERQYRKKD--ELQQEEEQLLREEREKRRLQE-------------- 1045

Query: 246  VFPTALRESQVAEEEEWLHKQAEARRAMNTDIAELCDLKEEEKNPEWLKDKGNKLFATE 304
                  RE Q  EEEE L ++ E       +     +L+ + +  E L+ +  +L   E
Sbjct: 1046 ------RERQYREEEE-LQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREE 1097



 Score = 42.4 bits (98), Expect = 7e-04
 Identities = 42/211 (19%), Positives = 94/211 (44%), Gaps = 14/211 (6%)

Query: 93   KEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENER 152
            +E  ++ RE+ +   ++  K   E +   ++E ++  L    ++  +ER++      + +
Sbjct: 1356 QERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRK 1415

Query: 153  IKATKALEAWKEYQRKAEEQ----KKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRN 208
             +  +   + +E  RK  E+    ++ +RE K  ++E+Q+++ER + K++   + L  R 
Sbjct: 1416 FREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHR-KFREEEQLLQERE 1474

Query: 209  LAPKGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPTALRESQVAEEEEWLHKQAE 268
                 R   +    K  E+     R     K  F  +   +   E +  EEE+ LH+Q  
Sbjct: 1475 EQQLHRQERD---RKFLEEEQQLRRQERDRK--FREQELRSQEPERKFLEEEQQLHRQQR 1529

Query: 269  ARRAMNTDIAELCDLKEEEKNPEWLKDKGNK 299
             R+ +     E   L+ +E+  +  +D+  K
Sbjct: 1530 QRKFLQ----EEQQLRRQERGQQRRQDRDRK 1556



 Score = 40.8 bits (94), Expect = 0.002
 Identities = 46/212 (21%), Positives = 97/212 (45%), Gaps = 22/212 (10%)

Query: 100 REKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEER----KKIEDMKENERIKA 155
           RE+ + + Q+  +E  E +   K E ++      +K E+EER    K+ E+ + +E+ + 
Sbjct: 415 REQQLRREQQLRREQEEERHEQKHEQERR--EQRLKREQEERRDWLKREEETERHEQERR 472

Query: 156 TKALEAWKEYQRKAEEQKKIQREEKLCQ---KEKQIKEERKKIKYKSLTRNLASRNLAPK 212
            + L+  +E +R+ E   K++ EE+  Q   +E+Q++ E+++ + + L R      L  +
Sbjct: 473 KQQLKRDQEEERR-ERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQR 531

Query: 213 GRNSENIFTE----------KLKEDSIPAPRSVGSIKINFTPRVFPTALRESQVAEEEEW 262
            R+ + +  E          + +E  +   R    +K     R      RE +    ++ 
Sbjct: 532 LRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEE--RRQQR 589

Query: 263 LHKQAEARRAMNTDIAELCDLKEEEKNPEWLK 294
           L ++ E R        E+  L++EE+  + LK
Sbjct: 590 LKREQEERLEQRLKREEVERLEQEERREQRLK 621



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 38/181 (20%), Positives = 80/181 (44%), Gaps = 9/181 (4%)

Query: 92  DKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKEN- 150
           ++   Q  RE+ + + QE  +E        KR++++  L   ++ E++ R++ E+ +E  
Sbjct: 495 ERREQQERREQQLRREQEERRE-----QRLKRQEEEERLQQRLRSEQQLRREQEERREQL 549

Query: 151 ERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLA 210
            + +  K LE  +  QR   EQ+  +R ++L ++E++ +++R K + +        R   
Sbjct: 550 LKREEEKRLEQERREQRLKREQE--ERRDQLLKREEERRQQRLKREQEERLEQRLKREEV 607

Query: 211 PKGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPTALRESQVAEEEEWLHKQAEAR 270
            +    E    ++LK +     R    +K           LR  Q    E+ L ++ E  
Sbjct: 608 ERLEQEER-REQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEE 666

Query: 271 R 271
           R
Sbjct: 667 R 667



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 42/175 (24%), Positives = 83/175 (47%), Gaps = 14/175 (8%)

Query: 92  DKEMMQRIR-EKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERK----KIED 146
           ++ + QR+R E+ + + QE  +E    +   KR +Q+      +K E+EER+    K E+
Sbjct: 525 EERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERR-EQRLKREQEERRDQLLKREE 583

Query: 147 MKENERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLAS 206
            +  +R+K  +  E   E + K EE +++++EE+  Q+ K+ + E ++ +    +     
Sbjct: 584 ERRQQRLK--REQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEE 641

Query: 207 RNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPTALRESQVAEEEE 261
           R      R  +    ++LK +     R    +K     R      RE ++AEEE+
Sbjct: 642 RRQQQLRREQQERREQRLKREE-EEERLEQRLK-----REHEEERREQELAEEEQ 690



 Score = 40.0 bits (92), Expect = 0.003
 Identities = 39/207 (18%), Positives = 90/207 (43%), Gaps = 12/207 (5%)

Query: 84   ETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKK 143
            E L   G ++++ ++ R++   + +++ +     +   + E Q     +  K  EEE+ +
Sbjct: 1673 EQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLR 1732

Query: 144  IEDMKENERIKAT--KALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLT 201
             E  +E  R +    K LE  +    + E+Q + Q  ++  ++E+Q+++ER++       
Sbjct: 1733 QETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREE------- 1785

Query: 202  RNLASRNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPTALRESQVAEEEE 261
            + L S+    K R  E +  E+ ++   P  R     K  +         +E ++ +E +
Sbjct: 1786 QQLRSQESDRKFREEEQLRQEREEQQLRPQQRDG---KYRWEEEQLQLEEQEQRLRQERD 1842

Query: 262  WLHKQAEARRAMNTDIAELCDLKEEEK 288
              ++  E          E  +L +EE+
Sbjct: 1843 RQYRAEEQFATQEKSRREEQELWQEEE 1869



 Score = 39.7 bits (91), Expect = 0.005
 Identities = 43/209 (20%), Positives = 96/209 (45%), Gaps = 14/209 (6%)

Query: 91  VDKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKEN 150
           + +E  QR RE    + Q R  E  E +   + E+Q+      ++ E++ R+K E+ +  
Sbjct: 260 LQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQ---RLRREQQLRRKQEEERRE 316

Query: 151 ERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQI-KEERKKIKYKSLTRNLASRNL 209
           ++ +  +  E  ++ + + E+Q + ++EE+   +E+Q+ +E+ ++ + + L R       
Sbjct: 317 QQEERREQQERREQQEERREQQLRREQEER---REQQLRREQEEERREQQLRREQEEERR 373

Query: 210 APKGRNSENIFTEK--LKEDSIPAPRSVGSIKINFTPRVFPTALRESQVAEEEEWLHKQA 267
             + R  + +  E+   +E  +   R    ++     R      RE Q+  E++   +Q 
Sbjct: 374 EQQLRREQQLRREQQLRREQQL---RREQQLRREQQLRREQQLRREQQLRREQQLRREQE 430

Query: 268 EARRAM--NTDIAELCDLKEEEKNPEWLK 294
           E R       +  E    +E+E+  +WLK
Sbjct: 431 EERHEQKHEQERREQRLKREQEERRDWLK 459



 Score = 39.3 bits (90), Expect = 0.006
 Identities = 32/179 (17%), Positives = 87/179 (48%), Gaps = 6/179 (3%)

Query: 92   DKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENE 151
            D++++Q  RE+  L  QER ++  E +   +R++++  L      +  E +++    E +
Sbjct: 1624 DEQLLQE-REEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQ 1682

Query: 152  RIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAP 211
            +++     E  ++++ + ++ ++ +RE K  Q+E+Q++ +  + K++     L       
Sbjct: 1683 QLRRQ---ERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFRE-EEQLRQETEQE 1738

Query: 212  KGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPTALRESQVAEEEEWLHKQAEAR 270
            + R  E  + + L+E+ +   R    ++     R F    +  Q  EE++   ++++ +
Sbjct: 1739 QLRRQER-YRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRK 1796



 Score = 38.9 bits (89), Expect = 0.008
 Identities = 38/183 (20%), Positives = 88/183 (48%), Gaps = 23/183 (12%)

Query: 92   DKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENE 151
            ++++++  REK  LQ  ER ++  E +   + E+Q          EE E ++ ++++   
Sbjct: 1030 EEQLLREEREKRRLQ--ERERQYREEEELQQEEEQLLG-------EERETRRRQELERQY 1080

Query: 152  RIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAP 211
            R K  +  +  ++  R+  E+++ Q  E+ C++E+++++E +++  +   +    + L  
Sbjct: 1081 R-KEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKR-RRQELER 1138

Query: 212  KGRNSENIFTEK---LKEDSIPAPRSVGSIKINFTPRVFPTALRESQVAEEEEWLHKQAE 268
            + R  E +  E+   L+E+  P  R    ++  +          E    EEE+ L ++ E
Sbjct: 1139 QYREEEEVQQEEEQLLREE--PEKRRRQELERQYRE-------EEELQQEEEQLLREEQE 1189

Query: 269  ARR 271
             RR
Sbjct: 1190 KRR 1192



 Score = 37.7 bits (86), Expect = 0.017
 Identities = 22/109 (20%), Positives = 60/109 (55%), Gaps = 2/109 (1%)

Query: 92   DKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKY-ALSVMMKIEEEERKKIEDMKEN 150
            ++++  + RE+ + Q ++R     E + + +  D+K+      ++ +E ERK +E+ ++ 
Sbjct: 1396 EQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQL 1455

Query: 151  ERIKATKALEAWKEYQRKAEEQ-KKIQREEKLCQKEKQIKEERKKIKYK 198
             + +  K  E  +  Q + E+Q  + +R+ K  ++E+Q++ + +  K++
Sbjct: 1456 RQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFR 1504



 Score = 36.2 bits (82), Expect = 0.050
 Identities = 27/116 (23%), Positives = 57/116 (49%), Gaps = 8/116 (6%)

Query: 93  KEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKEN-- 150
           +++++   ++   Q Q R ++    +   KRE+++  L   +K E EE ++ +++ E   
Sbjct: 631 QQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQ 690

Query: 151 ----ERIKATKALEAWK-EYQRKAEEQKKIQREEKL-CQKEKQIKEERKKIKYKSL 200
               ERIK+      W+ E +  A + K   R  K   Q+ +Q +EE+++ +   L
Sbjct: 691 EQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESEL 746



 Score = 35.8 bits (81), Expect = 0.066
 Identities = 47/237 (19%), Positives = 96/237 (40%), Gaps = 19/237 (8%)

Query: 68  NDTIVFTLYKKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKE----------ATEA 117
           N+ ++F     +A  +     TG+D+E   R   K  L    R +E            E 
Sbjct: 72  NEFLLFIFKVAQACYYALGQATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEE 131

Query: 118 KAAAKREDQKYALSVMMKIEEEERKKIEDMKENERIKATKAL----EAWKEYQRKAEEQK 173
           +   +R  ++      +   EE+ +K E +++ +R +  + L    + W+E + +  E++
Sbjct: 132 EPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEE 191

Query: 174 KIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAPR 233
           ++Q  +    +E   +E+ ++ +   L R         +    + +F E+ +E       
Sbjct: 192 QLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEE-EEKEWRKRE 250

Query: 234 SVGSIKINFTPRVFPTALRESQVAEEEEWLHK--QAEARRAMNTDIAELCDLKEEEK 288
           +V   +        P   RE Q  EEEE L K  + E RR    +  +   L+ E++
Sbjct: 251 TVLRKEEEKLQEEEPQRQRELQ--EEEEQLRKLERQELRRERQEEEQQQQRLRREQQ 305



 Score = 35.8 bits (81), Expect = 0.066
 Identities = 40/205 (19%), Positives = 94/205 (45%), Gaps = 24/205 (11%)

Query: 92   DKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDM---- 147
            ++E+ Q   E+ +L+ +   +   E +   +++D+       +  EE E++++++     
Sbjct: 993  EEELQQE--EEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQY 1050

Query: 148  KENERIKATKA--LEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLA 205
            +E E ++  +   L   +E +R+ E +++ ++EE+L Q+E+Q+  E  + K +   R   
Sbjct: 1051 REEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPE-KRRRQERERQ 1109

Query: 206  SRNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPTALRESQVAEEEEWLHK 265
             R      +  E +  E+ ++      R    ++  +          E    EEE+ L +
Sbjct: 1110 CREEEELQQEEEQLLREEREK------RRRQELERQYRE-------EEEVQQEEEQLLRE 1156

Query: 266  QAEARR--AMNTDIAELCDLKEEEK 288
            + E RR   +     E  +L++EE+
Sbjct: 1157 EPEKRRRQELERQYREEEELQQEEE 1181



 Score = 35.8 bits (81), Expect = 0.066
 Identities = 44/227 (19%), Positives = 89/227 (39%), Gaps = 18/227 (7%)

Query: 94   EMMQRIREKSILQAQERAKE-------ATEAKAAAKREDQKYALSVMMKIEEEERKKIED 146
            E  +R RE+   + Q+R +          E +  AKR D+K      +  EE E K+   
Sbjct: 1273 EQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQ 1332

Query: 147  MKENERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKE--KQIKEERKKIKYKSLTRNL 204
              + +  +  + L+  +E   + +E+ +  REE+L  +E  ++  EE ++++ +   R  
Sbjct: 1333 ETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKF 1392

Query: 205  ASRNLAPKGRNSENIFTE----KLKEDSIPAPRSVGSIKINFTPRVFPTALRESQVAEEE 260
                   + +  E    +    K +E+     R     K     +      RE +  EEE
Sbjct: 1393 LKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEE 1452

Query: 261  EWLHKQAEARRAMNTDIAELCDLKEEEKNPEWLKDKGNKLFATENYL 307
            + L ++   +      +     L+E E+     +++  K    E  L
Sbjct: 1453 QQLRQERHRKFREEEQL-----LQEREEQQLHRQERDRKFLEEEQQL 1494



 Score = 35.4 bits (80), Expect = 0.086
 Identities = 26/118 (22%), Positives = 63/118 (53%), Gaps = 7/118 (5%)

Query: 97  QRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERK-KIEDMKENERIKA 155
           Q  RE+ + + QE  ++  + +   +R +Q+     + + +EEER+ +   ++E ER + 
Sbjct: 440 QERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQ 499

Query: 156 TKALEAWKEYQRKAEEQKKIQR---EEKLCQK---EKQIKEERKKIKYKSLTRNLASR 207
            +  E     +++   +++++R   EE+L Q+   E+Q++ E+++ + + L R    R
Sbjct: 500 QERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKR 557



 Score = 35.0 bits (79), Expect = 0.11
 Identities = 48/214 (22%), Positives = 93/214 (43%), Gaps = 14/214 (6%)

Query: 93  KEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENER 152
           +E  +R R++  L A+   +E  E +  A+   Q+    +  + E+E+R++    +  ER
Sbjct: 774 EEKSERGRQR--LSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRR----QRRER 827

Query: 153 IKATKALEAWKEYQRKAEEQKKIQREEKL--CQKEKQIKEERKKIKYK---SLTRNLASR 207
            K  + LE  ++ QR+   Q+  + E+ L   Q+ ++ +E+R+  K++      R     
Sbjct: 828 EKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRH 887

Query: 208 NLAPKGRNSENIFTEK--LKEDSIPAPRSVGSIKINFTPRVFPTALRESQVAEEEEWLHK 265
            L  K    E +  E+  L+E+     R     K     +       E    EEE+ L +
Sbjct: 888 TLYAKPALQEQLRKEQQLLQEEEEELQREERE-KRRRQEQERQYREEEQLQQEEEQLLRE 946

Query: 266 QAEARRAMNTDIAELCDLKEEEKNPEWLKDKGNK 299
           + E RR    +     D K ++K  + L ++  K
Sbjct: 947 EREKRRRQERERQYRKDKKLQQKEEQLLGEEPEK 980



 Score = 34.7 bits (78), Expect = 0.15
 Identities = 41/202 (20%), Positives = 82/202 (40%), Gaps = 8/202 (3%)

Query: 100 REKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENERIKATKAL 159
           RE+ + + Q+  +E    +    R +Q+      ++ E+EE +  +  ++  R +  K  
Sbjct: 391 REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKRE 450

Query: 160 EAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSL----TRNLASRNLAPKGRN 215
           +  +    K EE+ +   +E+  Q+ K+ +EE ++ ++  L     R    R      R 
Sbjct: 451 QEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRRE 510

Query: 216 SENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPTALRESQVAEEEEWLHKQAEARRAMNT 275
            E    ++LK       R    ++     R      RE  +  EEE   +Q    + +  
Sbjct: 511 QEERREQRLKRQE-EEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKR 569

Query: 276 DIAELCD---LKEEEKNPEWLK 294
           +  E  D    +EEE+  + LK
Sbjct: 570 EQEERRDQLLKREEERRQQRLK 591



 Score = 34.7 bits (78), Expect = 0.15
 Identities = 40/200 (20%), Positives = 88/200 (44%), Gaps = 13/200 (6%)

Query: 93   KEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENER 152
            +E  Q  +E+  L  +ER K   + +    R+D+K        + EE  K+    +E + 
Sbjct: 931  REEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKY 990

Query: 153  IKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAPK 212
             +  +  +  ++  R+  E+++ Q  E+  +K+ ++++E +++    L      R L  +
Sbjct: 991  REEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQL----LREEREKRRLQER 1046

Query: 213  GRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPTALR--ESQVAEEEEWLHKQAEAR 270
             R       E+L+++     + +G  +     +      R  E    EEE+ L ++ E R
Sbjct: 1047 ERQYRE--EEELQQEE---EQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKR 1101

Query: 271  RAMNTD--IAELCDLKEEEK 288
            R    +    E  +L++EE+
Sbjct: 1102 RRQERERQCREEEELQQEEE 1121



 Score = 34.3 bits (77), Expect = 0.19
 Identities = 23/110 (20%), Positives = 55/110 (50%)

Query: 93   KEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENER 152
            +E  ++ RE+  LQ +E      E +   ++E ++         +EEE+   E+ ++  R
Sbjct: 1104 QERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRR 1163

Query: 153  IKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTR 202
             +  +     +E Q++ E+  + ++E++  ++E+Q +EE +  + K   R
Sbjct: 1164 QELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQR 1213



 Score = 33.5 bits (75), Expect = 0.33
 Identities = 25/122 (20%), Positives = 58/122 (47%), Gaps = 3/122 (2%)

Query: 77   KKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKI 136
            K+E    E   +   + E  +R   +   + +E  ++  E     +RE ++         
Sbjct: 1082 KEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYR 1141

Query: 137  EEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIK 196
            EEEE ++ E+    E  +  +  E  ++Y+   EE++  Q EE+L ++E++ + + ++ +
Sbjct: 1142 EEEEVQQEEEQLLREEPEKRRRQELERQYR---EEEELQQEEEQLLREEQEKRRQERERQ 1198

Query: 197  YK 198
            Y+
Sbjct: 1199 YR 1200



 Score = 32.3 bits (72), Expect = 0.73
 Identities = 18/99 (18%), Positives = 51/99 (51%), Gaps = 1/99 (1%)

Query: 100  REKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENERIKATKAL 159
            +E+  L  +ER K   +      RE+++        + EE  K+     E +  +  +  
Sbjct: 1118 QEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQ 1177

Query: 160  EAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYK 198
            +  ++  R+ +E+++ +RE +  ++E++++ +++K +Y+
Sbjct: 1178 QEEEQLLREEQEKRRQERERQY-REEEELQRQKRKQRYR 1215



 Score = 32.0 bits (71), Expect = 0.95
 Identities = 43/210 (20%), Positives = 91/210 (43%), Gaps = 41/210 (19%)

Query: 4    QVSDYSWQQTKTAVFLSLPLKGVCVRDTDVFCTENYLKVNFPPFLFEAFLYAPIDDESSK 63
            Q SD  WQ          P K   VRD  V+C              E   +  ++D   +
Sbjct: 1219 QRSDLKWQWE--------PEKENAVRDNKVYCKGR-----------ENEQFRQLEDSQLR 1259

Query: 64   AKIGNDTIVFTL-------YKKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATE 116
             +     +   L        ++E   W+       ++E ++R  +K   +A+ R +++ E
Sbjct: 1260 DRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQK---EAKRRDRKSQE 1316

Query: 117  AKAAAK--REDQKYALSVMMKIEEEER----KKIEDMKENERIKATKALEAWKEYQRKA- 169
             K   +  RE+++       K  EEE+    ++ + ++  ER +  +  E   + Q +  
Sbjct: 1317 EKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKF 1376

Query: 170  -EEQKKIQREE---KLCQKEKQIK-EERKK 194
             EE+++++R+E   K  ++E+Q++ +ER++
Sbjct: 1377 LEEEQRLRRQERERKFLKEEQQLRCQEREQ 1406



 Score = 30.8 bits (68), Expect = 2.1
 Identities = 21/107 (19%), Positives = 53/107 (49%)

Query: 92  DKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENE 151
           ++   Q  RE+ + + Q+  +E    +    R +Q+      ++ E++ R++ +  +E E
Sbjct: 371 ERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQE 430

Query: 152 RIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYK 198
             +  +  E  +  QR   EQ++ +   K  ++ ++ ++ER+K + K
Sbjct: 431 EERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLK 477



 Score = 29.3 bits (64), Expect = 6.2
 Identities = 35/235 (14%), Positives = 92/235 (39%), Gaps = 35/235 (14%)

Query: 92   DKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENE 151
            ++++ ++ +E+  ++ +++ +     +   +  D+K+     +  E EE++     ++ +
Sbjct: 1585 EQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRK 1644

Query: 152  RIKATKALEAWKEYQRKAEEQKKIQREEKLC-------------------QKEKQIKEER 192
             ++    L   +  Q+   ++ +  REE+                     ++E+Q++ + 
Sbjct: 1645 FLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQE 1704

Query: 193  KKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPTALR 252
            ++ K+    + L  + L  K R  E +  E  +E      R             +   L 
Sbjct: 1705 RERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQER-------------YRKILE 1751

Query: 253  ESQVAEEEEWLHKQAEARRAMNTDIAELCDLKEEEKNPEWLKDKGNKLFATENYL 307
            E Q+  E E   +Q   R+  +    E   L++E +  +    + ++ F  E  L
Sbjct: 1752 EEQLRPERE---EQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQL 1803



 Score = 28.9 bits (63), Expect = 8.0
 Identities = 41/202 (20%), Positives = 84/202 (41%), Gaps = 13/202 (6%)

Query: 93   KEMMQRIREKSILQAQERA--KEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKEN 150
            +E+ ++ RE+  +Q +E    +E  E +   + E Q      + + EE+  ++ ++ +  
Sbjct: 1134 QELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQ 1193

Query: 151  ERIKATKALEAWKEYQRKAEEQKKIQREEKLCQ----KEKQIKEERKKIKYKSLTRNLAS 206
            ER +  +  E  +  +RK   + + QR +   Q    KE  +++ +   K +   +    
Sbjct: 1194 ERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQL 1253

Query: 207  RNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPTALRESQVAEEEEWLHKQ 266
             +   + R S+      L E      R     +     R FP    E Q+  EE+   K+
Sbjct: 1254 EDSQLRDRQSQQDLQHLLGEQQ-ERDREQERRRWQQRDRHFP---EEEQLEREEQ---KE 1306

Query: 267  AEARRAMNTDIAELCDLKEEEK 288
            A+ R   + +  +L   + EEK
Sbjct: 1307 AKRRDRKSQEEKQLLREEREEK 1328


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.128    0.360 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,679,059
Number of Sequences: 37866
Number of extensions: 613239
Number of successful extensions: 10149
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 327
Number of HSP's successfully gapped in prelim test: 681
Number of HSP's that attempted gapping in prelim test: 4049
Number of HSP's gapped (non-prelim): 3482
length of query: 381
length of database: 18,247,518
effective HSP length: 104
effective length of query: 277
effective length of database: 14,309,454
effective search space: 3963718758
effective search space used: 3963718758
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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