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Search of human proteins with 75677374
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|75677374 SLIT-ROBO Rho GTPase activating protein 3 isoform b
[Homo sapiens]
(1075 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|75677374 SLIT-ROBO Rho GTPase activating protein 3 isoform b ... 2142 0.0
gi|24307967 SLIT-ROBO Rho GTPase activating protein 3 isoform a ... 2106 0.0
gi|44917604 SLIT-ROBO Rho GTPase activating protein 1 [Homo sapi... 1410 0.0
gi|112363100 SLIT-ROBO Rho GTPase activating protein 2 isoform a... 1246 0.0
gi|112363096 SLIT-ROBO Rho GTPase activating protein 2 isoform b... 1119 0.0
gi|156071465 Rho GTPase activating protein 4 [Homo sapiens] 763 0.0
gi|34013590 Rho GTPase activating protein 2 [Homo sapiens] 117 8e-26
gi|224458284 Rho GTPase activating protein 23 [Homo sapiens] 114 5e-25
gi|111154090 Rho GTPase activating protein 24 isoform 3 [Homo sa... 113 8e-25
gi|111154099 Rho GTPase activating protein 24 isoform 2 [Homo sa... 113 8e-25
gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo sa... 113 8e-25
gi|203097003 Rho GTPase activating protein 21 [Homo sapiens] 111 3e-24
gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens] 107 5e-23
gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens] 107 5e-23
gi|4757980 beta chimerin isoform 2 [Homo sapiens] 106 1e-22
gi|91106928 beta chimerin isoform 1 [Homo sapiens] 106 1e-22
gi|226693398 Rho GTPase activating protein 27 isoform b [Homo sa... 100 1e-20
gi|40548322 Rho GTPase activating protein 27 isoform a [Homo sap... 100 1e-20
gi|150417981 glucocorticoid receptor DNA binding factor 1 [Homo ... 99 2e-20
gi|71834863 Rho GTPase activating protein 5 isoform a [Homo sapi... 99 2e-20
gi|71834861 Rho GTPase activating protein 5 isoform b [Homo sapi... 99 2e-20
gi|7382480 Rho GTPase activating protein 6 isoform 4 [Homo sapiens] 98 4e-20
gi|95091875 Rho GTPase activating protein 6 isoform 1 [Homo sapi... 98 4e-20
gi|95091988 Rho GTPase activating protein 6 isoform 3 [Homo sapi... 97 8e-20
gi|4757766 Rho GTPase activating protein 1 [Homo sapiens] 94 7e-19
gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens] 94 9e-19
gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens] 94 9e-19
gi|26986534 Rho GTPase activating protein 12 [Homo sapiens] 92 2e-18
gi|188497642 ARHGAP15 [Homo sapiens] 91 6e-18
gi|91208437 GEM interacting protein [Homo sapiens] 90 1e-17
>gi|75677374 SLIT-ROBO Rho GTPase activating protein 3 isoform b [Homo
sapiens]
Length = 1075
Score = 2142 bits (5549), Expect = 0.0
Identities = 1075/1075 (100%), Positives = 1075/1075 (100%)
Query: 1 MSSQTKFKKDKEIIAEYEAQIKEIRTQLVEQFKCLEQQSESRLQLLQDLQEFFRRKAEIE 60
MSSQTKFKKDKEIIAEYEAQIKEIRTQLVEQFKCLEQQSESRLQLLQDLQEFFRRKAEIE
Sbjct: 1 MSSQTKFKKDKEIIAEYEAQIKEIRTQLVEQFKCLEQQSESRLQLLQDLQEFFRRKAEIE 60
Query: 61 LEYSRSLEKLAERFSSKIRSSREHQFKKDQYLLSPVNCWYLVLHQTRRESRDHATLNDIF 120
LEYSRSLEKLAERFSSKIRSSREHQFKKDQYLLSPVNCWYLVLHQTRRESRDHATLNDIF
Sbjct: 61 LEYSRSLEKLAERFSSKIRSSREHQFKKDQYLLSPVNCWYLVLHQTRRESRDHATLNDIF 120
Query: 121 MNNVIVRLSQISEDVIRLFKKSKEIGLQMHEELLKVTNELYTVMKTYHMYHAESISAESK 180
MNNVIVRLSQISEDVIRLFKKSKEIGLQMHEELLKVTNELYTVMKTYHMYHAESISAESK
Sbjct: 121 MNNVIVRLSQISEDVIRLFKKSKEIGLQMHEELLKVTNELYTVMKTYHMYHAESISAESK 180
Query: 181 LKEAEKQEEKQFNKSGDLSMNLLRHEDRPQRRSSVKKIEKMKEKRQAKYSENKLKCTKAR 240
LKEAEKQEEKQFNKSGDLSMNLLRHEDRPQRRSSVKKIEKMKEKRQAKYSENKLKCTKAR
Sbjct: 181 LKEAEKQEEKQFNKSGDLSMNLLRHEDRPQRRSSVKKIEKMKEKRQAKYSENKLKCTKAR 240
Query: 241 NDYLLNLAATNAAISKYYIHDVSDLIDCCDLGFHASLARTFRTYLSAEYNLETSRHEGLD 300
NDYLLNLAATNAAISKYYIHDVSDLIDCCDLGFHASLARTFRTYLSAEYNLETSRHEGLD
Sbjct: 241 NDYLLNLAATNAAISKYYIHDVSDLIDCCDLGFHASLARTFRTYLSAEYNLETSRHEGLD 300
Query: 301 VIENAVDNLDSRSDKHTVMDMCNQVFCPPLKFEFQPHMGDEVCQVSAQQPVQTELLMRYH 360
VIENAVDNLDSRSDKHTVMDMCNQVFCPPLKFEFQPHMGDEVCQVSAQQPVQTELLMRYH
Sbjct: 301 VIENAVDNLDSRSDKHTVMDMCNQVFCPPLKFEFQPHMGDEVCQVSAQQPVQTELLMRYH 360
Query: 361 QLQSRLATLKIENEEVRKTLDATMQTLQDMLTVEDFDVSDAFQHSRSTESVKSAASETYM 420
QLQSRLATLKIENEEVRKTLDATMQTLQDMLTVEDFDVSDAFQHSRSTESVKSAASETYM
Sbjct: 361 QLQSRLATLKIENEEVRKTLDATMQTLQDMLTVEDFDVSDAFQHSRSTESVKSAASETYM 420
Query: 421 SKINIAKRRANQQETEMFYFTKFKEYVNGSNLITKLQAKHDLLKQTLGEGERAECGTTRG 480
SKINIAKRRANQQETEMFYFTKFKEYVNGSNLITKLQAKHDLLKQTLGEGERAECGTTRG
Sbjct: 421 SKINIAKRRANQQETEMFYFTKFKEYVNGSNLITKLQAKHDLLKQTLGEGERAECGTTRG 480
Query: 481 RRNARTRNQDSGQAIPLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFERGEDPL 540
RRNARTRNQDSGQAIPLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFERGEDPL
Sbjct: 481 RRNARTRNQDSGQAIPLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFERGEDPL 540
Query: 541 VDDQNERDINSVAGVLKLYFRGLENPLFPKERFQDLISTIKLENPAERVHQIQQILVTLP 600
VDDQNERDINSVAGVLKLYFRGLENPLFPKERFQDLISTIKLENPAERVHQIQQILVTLP
Sbjct: 541 VDDQNERDINSVAGVLKLYFRGLENPLFPKERFQDLISTIKLENPAERVHQIQQILVTLP 600
Query: 601 RVVIVVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMHIPDGQDPVSCQAHINEVIK 660
RVVIVVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMHIPDGQDPVSCQAHINEVIK
Sbjct: 601 RVVIVVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMHIPDGQDPVSCQAHINEVIK 660
Query: 661 TIIIHHEAIFPSPRELEGPVYEKCMAGGEEYCDSPHSEPGAIDEVDHDNGTEPHTSDEEV 720
TIIIHHEAIFPSPRELEGPVYEKCMAGGEEYCDSPHSEPGAIDEVDHDNGTEPHTSDEEV
Sbjct: 661 TIIIHHEAIFPSPRELEGPVYEKCMAGGEEYCDSPHSEPGAIDEVDHDNGTEPHTSDEEV 720
Query: 721 EQIEAIAKFDYMGRSPRELSFKKGASLLLYHRASEDWWEGRHNGVDGLIPHQYIVVQDMD 780
EQIEAIAKFDYMGRSPRELSFKKGASLLLYHRASEDWWEGRHNGVDGLIPHQYIVVQDMD
Sbjct: 721 EQIEAIAKFDYMGRSPRELSFKKGASLLLYHRASEDWWEGRHNGVDGLIPHQYIVVQDMD 780
Query: 781 DAFSDSLSQKADSEASSGPLLDDKASSKNDLQSPTEHISDYGFGGVMGRVRLRSDGAAIP 840
DAFSDSLSQKADSEASSGPLLDDKASSKNDLQSPTEHISDYGFGGVMGRVRLRSDGAAIP
Sbjct: 781 DAFSDSLSQKADSEASSGPLLDDKASSKNDLQSPTEHISDYGFGGVMGRVRLRSDGAAIP 840
Query: 841 RRRSGGDTHSPPRGLGPSIDTPPRAAACPSSPHKIPLTRGRIESPEKRRMATFGSAGSIN 900
RRRSGGDTHSPPRGLGPSIDTPPRAAACPSSPHKIPLTRGRIESPEKRRMATFGSAGSIN
Sbjct: 841 RRRSGGDTHSPPRGLGPSIDTPPRAAACPSSPHKIPLTRGRIESPEKRRMATFGSAGSIN 900
Query: 901 YPDKKALSEGHSMRSTCGSTRHSSLGDHKSLEAEALAEDIEKTMSTALHELRELERQNTV 960
YPDKKALSEGHSMRSTCGSTRHSSLGDHKSLEAEALAEDIEKTMSTALHELRELERQNTV
Sbjct: 901 YPDKKALSEGHSMRSTCGSTRHSSLGDHKSLEAEALAEDIEKTMSTALHELRELERQNTV 960
Query: 961 KQAPDVVLDTLEPLKNPPGPVSSEPASPLHTIVIRDPDAAMRRSSSSSTEMMTTFKPALS 1020
KQAPDVVLDTLEPLKNPPGPVSSEPASPLHTIVIRDPDAAMRRSSSSSTEMMTTFKPALS
Sbjct: 961 KQAPDVVLDTLEPLKNPPGPVSSEPASPLHTIVIRDPDAAMRRSSSSSTEMMTTFKPALS 1020
Query: 1021 ARLAGAQLRPPPMRPVRPVVQHRSSSSSSSGVGSPAVTPTEKMFPNSSADKSGTM 1075
ARLAGAQLRPPPMRPVRPVVQHRSSSSSSSGVGSPAVTPTEKMFPNSSADKSGTM
Sbjct: 1021 ARLAGAQLRPPPMRPVRPVVQHRSSSSSSSGVGSPAVTPTEKMFPNSSADKSGTM 1075
>gi|24307967 SLIT-ROBO Rho GTPase activating protein 3 isoform a [Homo
sapiens]
Length = 1099
Score = 2106 bits (5457), Expect = 0.0
Identities = 1067/1099 (97%), Positives = 1070/1099 (97%), Gaps = 24/1099 (2%)
Query: 1 MSSQTKFKKDKEIIAEYEAQIKEIRTQLVEQFKCLEQQSESRLQLLQDLQEFFRRKAEIE 60
MSSQTKFKKDKEIIAEYEAQIKEIRTQLVEQFKCLEQQSESRLQLLQDLQEFFRRKAEIE
Sbjct: 1 MSSQTKFKKDKEIIAEYEAQIKEIRTQLVEQFKCLEQQSESRLQLLQDLQEFFRRKAEIE 60
Query: 61 LEYSRSLEKLAERFSSKIRSSREHQFKKDQYLLSPVNCWYLVLHQTRRESRDHATLNDIF 120
LEYSRSLEKLAERFSSKIRSSREHQFKKDQYLLSPVNCWYLVLHQTRRESRDHATLNDIF
Sbjct: 61 LEYSRSLEKLAERFSSKIRSSREHQFKKDQYLLSPVNCWYLVLHQTRRESRDHATLNDIF 120
Query: 121 MNNVIVRLSQISEDVIRLFKKSKEIGLQMHEELLKVTNELYTVMKTYHMYHAESISAESK 180
MNNVIVRLSQISEDVIRLFKKSKEIGLQMHEELLKVTNELYTVMKTYHMYHAESISAESK
Sbjct: 121 MNNVIVRLSQISEDVIRLFKKSKEIGLQMHEELLKVTNELYTVMKTYHMYHAESISAESK 180
Query: 181 LKEAEKQEEKQFNKSGDLSMNLLRHEDRPQRRSSVKKIEKMKEKRQAKYSENKLKCTKAR 240
LKEAEKQEEKQFNKSGDLSMNLLRHEDRPQRRSSVKKIEKMKEKRQAKYSENKLKCTKAR
Sbjct: 181 LKEAEKQEEKQFNKSGDLSMNLLRHEDRPQRRSSVKKIEKMKEKRQAKYSENKLKCTKAR 240
Query: 241 NDYLLNLAATNAAISKYYIHDVSDLIDCCDLGFHASLARTFRTYLSAEYNLETSRHEGLD 300
NDYLLNLAATNAAISKYYIHDVSDLIDCCDLGFHASLARTFRTYLSAEYNLETSRHEGLD
Sbjct: 241 NDYLLNLAATNAAISKYYIHDVSDLIDCCDLGFHASLARTFRTYLSAEYNLETSRHEGLD 300
Query: 301 VIENAVDNLDSRSDKHTVMDMCNQVFCPPLKFEFQPHMGDEVCQVSAQQPVQTELLMRYH 360
VIENAVDNLDSRSDKHTVMDMCNQVFCPPLKFEFQPHMGDEVCQVSAQQPVQTELLMRYH
Sbjct: 301 VIENAVDNLDSRSDKHTVMDMCNQVFCPPLKFEFQPHMGDEVCQVSAQQPVQTELLMRYH 360
Query: 361 QLQSRLATLKIENEEVRKTLDATMQTLQDMLTVEDFDVSDAFQHSRSTESVKSAASETYM 420
QLQSRLATLKIENEEVRKTLDATMQTLQDMLTVEDFDVSDAFQHSRSTESVKSAASETYM
Sbjct: 361 QLQSRLATLKIENEEVRKTLDATMQTLQDMLTVEDFDVSDAFQHSRSTESVKSAASETYM 420
Query: 421 SKINIAKRRANQQETEMFYFTKFKEYVNGSNLITKLQAKHDLLKQTLGEGERAECGTTRG 480
SKINIAKRRANQQETEMFYFTKFKEYVNGSNLITKLQAKHDLLKQTLGEGERAECGTTR
Sbjct: 421 SKINIAKRRANQQETEMFYFTKFKEYVNGSNLITKLQAKHDLLKQTLGEGERAECGTTRP 480
Query: 481 -------RRNARTRN-----------------QDSGQAIPLVVESCIRYINLYGLQQQGI 516
++ R R +DSGQAIPLVVESCIRYINLYGLQQQGI
Sbjct: 481 PCLPPKPQKMRRPRPLSVYSHKLFNGSMEAFIKDSGQAIPLVVESCIRYINLYGLQQQGI 540
Query: 517 FRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAGVLKLYFRGLENPLFPKERFQDL 576
FRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAGVLKLYFRGLENPLFPKERFQDL
Sbjct: 541 FRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAGVLKLYFRGLENPLFPKERFQDL 600
Query: 577 ISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAFLNHLSQYSDENMMDPYNLAICFG 636
ISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAFLNHLSQYSDENMMDPYNLAICFG
Sbjct: 601 ISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAFLNHLSQYSDENMMDPYNLAICFG 660
Query: 637 PTLMHIPDGQDPVSCQAHINEVIKTIIIHHEAIFPSPRELEGPVYEKCMAGGEEYCDSPH 696
PTLMHIPDGQDPVSCQAHINEVIKTIIIHHEAIFPSPRELEGPVYEKCMAGGEEYCDSPH
Sbjct: 661 PTLMHIPDGQDPVSCQAHINEVIKTIIIHHEAIFPSPRELEGPVYEKCMAGGEEYCDSPH 720
Query: 697 SEPGAIDEVDHDNGTEPHTSDEEVEQIEAIAKFDYMGRSPRELSFKKGASLLLYHRASED 756
SEPGAIDEVDHDNGTEPHTSDEEVEQIEAIAKFDYMGRSPRELSFKKGASLLLYHRASED
Sbjct: 721 SEPGAIDEVDHDNGTEPHTSDEEVEQIEAIAKFDYMGRSPRELSFKKGASLLLYHRASED 780
Query: 757 WWEGRHNGVDGLIPHQYIVVQDMDDAFSDSLSQKADSEASSGPLLDDKASSKNDLQSPTE 816
WWEGRHNGVDGLIPHQYIVVQDMDDAFSDSLSQKADSEASSGPLLDDKASSKNDLQSPTE
Sbjct: 781 WWEGRHNGVDGLIPHQYIVVQDMDDAFSDSLSQKADSEASSGPLLDDKASSKNDLQSPTE 840
Query: 817 HISDYGFGGVMGRVRLRSDGAAIPRRRSGGDTHSPPRGLGPSIDTPPRAAACPSSPHKIP 876
HISDYGFGGVMGRVRLRSDGAAIPRRRSGGDTHSPPRGLGPSIDTPPRAAACPSSPHKIP
Sbjct: 841 HISDYGFGGVMGRVRLRSDGAAIPRRRSGGDTHSPPRGLGPSIDTPPRAAACPSSPHKIP 900
Query: 877 LTRGRIESPEKRRMATFGSAGSINYPDKKALSEGHSMRSTCGSTRHSSLGDHKSLEAEAL 936
LTRGRIESPEKRRMATFGSAGSINYPDKKALSEGHSMRSTCGSTRHSSLGDHKSLEAEAL
Sbjct: 901 LTRGRIESPEKRRMATFGSAGSINYPDKKALSEGHSMRSTCGSTRHSSLGDHKSLEAEAL 960
Query: 937 AEDIEKTMSTALHELRELERQNTVKQAPDVVLDTLEPLKNPPGPVSSEPASPLHTIVIRD 996
AEDIEKTMSTALHELRELERQNTVKQAPDVVLDTLEPLKNPPGPVSSEPASPLHTIVIRD
Sbjct: 961 AEDIEKTMSTALHELRELERQNTVKQAPDVVLDTLEPLKNPPGPVSSEPASPLHTIVIRD 1020
Query: 997 PDAAMRRSSSSSTEMMTTFKPALSARLAGAQLRPPPMRPVRPVVQHRSSSSSSSGVGSPA 1056
PDAAMRRSSSSSTEMMTTFKPALSARLAGAQLRPPPMRPVRPVVQHRSSSSSSSGVGSPA
Sbjct: 1021 PDAAMRRSSSSSTEMMTTFKPALSARLAGAQLRPPPMRPVRPVVQHRSSSSSSSGVGSPA 1080
Query: 1057 VTPTEKMFPNSSADKSGTM 1075
VTPTEKMFPNSSADKSGTM
Sbjct: 1081 VTPTEKMFPNSSADKSGTM 1099
>gi|44917604 SLIT-ROBO Rho GTPase activating protein 1 [Homo sapiens]
Length = 1085
Score = 1410 bits (3651), Expect = 0.0
Identities = 736/1095 (67%), Positives = 871/1095 (79%), Gaps = 47/1095 (4%)
Query: 1 MSSQTKFKKDKEIIAEYEAQIKEIRTQLVEQFKCLEQQSESRLQLLQDLQEFFRRKAEIE 60
MS+ ++FKKDKEIIAEYE+Q+KEIR QLVEQ KCLEQQ+E R+QLLQDLQ+FFR+KAEIE
Sbjct: 1 MSTPSRFKKDKEIIAEYESQVKEIRAQLVEQQKCLEQQTEMRVQLLQDLQDFFRKKAEIE 60
Query: 61 LEYSRSLEKLAERFSSKIRSSREHQ-FKKDQYLLSPVNCWYLVLHQTRRESRDHATLNDI 119
EYSR+LEKLAERF +K RS+++HQ +KKDQ LLSPVNCWYL+L+Q RRES+DHATL+DI
Sbjct: 61 TEYSRNLEKLAERFMAKTRSTKDHQQYKKDQNLLSPVNCWYLLLNQVRRESKDHATLSDI 120
Query: 120 FMNNVIVRLSQISEDVIRLFKKSKEIGLQMHEELLKVTNELYTVMKTYHMYHAESISAES 179
++NNVI+R QISED R+FKKSKEI Q+HE+L+KV NELYTVMKTYHMYHAESISAES
Sbjct: 121 YLNNVIMRFMQISEDSTRMFKKSKEIAFQLHEDLMKVLNELYTVMKTYHMYHAESISAES 180
Query: 180 KLKEAEKQEEKQFNKSGDLSMNLLRHEDRPQRRSSVKKIEKMKEKRQAKYSENKLKCTKA 239
KLKEAEKQEEKQ +SGD ++ R E+R QRRSSVKKIEKMKEKRQAKYSENKLK KA
Sbjct: 181 KLKEAEKQEEKQIGRSGDPVFHI-RLEERHQRRSSVKKIEKMKEKRQAKYSENKLKSIKA 239
Query: 240 RNDYLLNLAATNAAISKYYIHDVSDLIDCCDLGFHASLARTFRTYLSAEYNLETSRHEGL 299
RN+YLL L ATNA++ KYYIHD+SDLIDCCDLG+HASL R RTYLSAEYNLETSRHEGL
Sbjct: 240 RNEYLLTLEATNASVFKYYIHDLSDLIDCCDLGYHASLNRALRTYLSAEYNLETSRHEGL 299
Query: 300 DVIENAVDNLDSRSDKHTVMDMCNQVFCPPLKFEFQPHMGDEVCQVSAQQPVQTELLMRY 359
D+IENAVDNL+ RSDK M+M FCPP+KFEFQ HMGDEVCQVSAQQPVQ EL++RY
Sbjct: 300 DIIENAVDNLEPRSDKQRFMEMYPAAFCPPMKFEFQSHMGDEVCQVSAQQPVQAELMLRY 359
Query: 360 HQLQSRLATLKIENEEVRKTLDATMQTLQDMLTVEDFDVSDAFQHSRSTESVKSAASETY 419
QLQSRLATLKIENEEV+KT +AT+QT+QDM+T+ED+DVS+ FQHSRSTESVKS SETY
Sbjct: 360 QQLQSRLATLKIENEEVKKTTEATLQTIQDMVTIEDYDVSECFQHSRSTESVKSTVSETY 419
Query: 420 MSKINIAKRRANQQETEMFYFTKFKEYVNGSNLITKLQAKHDLLKQTLGEGERAECGTTR 479
+SK +IAKRRANQQETE FYF K +EY+ GSNLITKLQAKHDLL++TLGEG RAE TTR
Sbjct: 420 LSKPSIAKRRANQQETEQFYFMKLREYLEGSNLITKLQAKHDLLQRTLGEGHRAEYMTTR 479
Query: 480 ---------GRRNARTRNQ---------------DSGQAIPLVVESCIRYINLYGLQQQG 515
R +R R+Q DSGQ IPL+VESCIR+INLYGLQ QG
Sbjct: 480 PPNVPPKPQKHRKSRPRSQYNTKLFNGDLETFVKDSGQVIPLIVESCIRFINLYGLQHQG 539
Query: 516 IFRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAGVLKLYFRGLENPLFPKERFQD 575
IFRV GSQVEVNDIKNSFERGE+PL DDQ+ DINSVAGVLKLYFRGLENPLFPKERF D
Sbjct: 540 IFRVSGSQVEVNDIKNSFERGENPLADDQSNHDINSVAGVLKLYFRGLENPLFPKERFND 599
Query: 576 LISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAFLNHLSQYSDENMMDPYNLAICF 635
LIS I+++N ER I+++L+TLPR V++VMRYLFAFLNHLSQYSDENMMDPYNLAICF
Sbjct: 600 LISCIRIDNLYERALHIRKLLLTLPRSVLIVMRYLFAFLNHLSQYSDENMMDPYNLAICF 659
Query: 636 GPTLMHIPDGQDPVSCQAHINEVIKTIIIHHEAIFPSPRELEGPVYEKCMAGGEEYCDSP 695
GPTLM +P+ QD VSCQAH+NE+IKTIIIHHE IFP +EL+GPVYEKCMA G++YCDSP
Sbjct: 660 GPTLMPVPEIQDQVSCQAHVNEIIKTIIIHHETIFPDAKELDGPVYEKCMA-GDDYCDSP 718
Query: 696 HSEPGAIDEVDHDNGTEPHTSDEEVEQIEAIAKFDYMGRSPRELSFKKGASLLLYHRASE 755
+SE G ++EVD D GTEPHTS++E E IEAIAKFDY+GRS RELSFKKGASLLLYHRASE
Sbjct: 719 YSEHGTLEEVDQDAGTEPHTSEDECEPIEAIAKFDYVGRSARELSFKKGASLLLYHRASE 778
Query: 756 DWWEGRHNGVDGLIPHQYIVVQDMDDAFSDSLSQKADSEASSGPLLDDKASSKNDLQSPT 815
DWWEGRHNG+DGL+PHQYIVVQDMDD FSD+LSQKADSEASSGP+ +DK+SSK D+ SPT
Sbjct: 779 DWWEGRHNGIDGLVPHQYIVVQDMDDTFSDTLSQKADSEASSGPVTEDKSSSK-DMNSPT 837
Query: 816 EHISDYGFGGVMGRVRLRSDGAAIPRRRSG--GDTH---SPPRGL-GPSIDTPPRAAACP 869
+ D G + R R R + P RR G D H PP L S+D + A
Sbjct: 838 DRHPD----GYLARQRKRGEPPP-PVRRPGRTSDGHCPLHPPHALSNSSVDLGSPSLA-- 890
Query: 870 SSPHKIPLTRG-RIESPEKRRMATFGSAGSINYPDKKALSEGHSMRSTCGSTRHSSLGDH 928
S P + RG +SPE+RR GS +I+ D + +R + S +++ DH
Sbjct: 891 SHPRGLLQNRGLNNDSPERRRRPGHGSLTNISRHDSLKKIDSPPIRRSTSSGQYTGFNDH 950
Query: 929 KSLEAEALAEDIEKTMSTALHELRELERQNTVKQAPDVVLDTLEPLKNPPGP-VSSEPAS 987
K L+ E +A+DIE+TM+TAL+ELRELERQ+T K APDVVLDTLE +KN P P S+E S
Sbjct: 951 KPLDPETIAQDIEETMNTALNELRELERQSTAKHAPDVVLDTLEQVKNSPTPATSTESLS 1010
Query: 988 PLHTIVIRDPDAAMRRSSSSSTEMMTTFKPALSARLAGAQLRPPPMRPVRPVVQHRSSSS 1047
PLH + +R + +RRS+SSS++ M+TFKP ++ R+ G QL+PP +RP +P V + ++
Sbjct: 1011 PLHNVALRSSEPQIRRSTSSSSDTMSTFKPMVAPRM-GVQLKPPALRP-KPAVLPK--TN 1066
Query: 1048 SSSGVGSPAVTPTEK 1062
+ G P PT+K
Sbjct: 1067 PTIGPAPPPQGPTDK 1081
>gi|112363100 SLIT-ROBO Rho GTPase activating protein 2 isoform a
[Homo sapiens]
Length = 1071
Score = 1246 bits (3223), Expect = 0.0
Identities = 646/1079 (59%), Positives = 823/1079 (76%), Gaps = 29/1079 (2%)
Query: 1 MSSQTKFKKDKEIIAEYEAQIKEIRTQLVEQFKCLEQQSESRLQLLQDLQEFFRRKAEIE 60
M+S KFKKDKEIIAEY+ Q+KEIR QL EQ KCL+QQ E R+QLLQDLQ+FFR+KAEIE
Sbjct: 1 MTSPAKFKKDKEIIAEYDTQVKEIRAQLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIE 60
Query: 61 LEYSRSLEKLAERFSSKIRSSREHQFKKDQYLLSPVNCWYLVLHQTRRESRDHATLNDIF 120
++YSR+LEKLAERF +K RS+++ QFKKDQ +LSPVNCW L+L+Q +RESRDH TL+DI+
Sbjct: 61 MDYSRNLEKLAERFLAKTRSTKDQQFKKDQNVLSPVNCWNLLLNQVKRESRDHTTLSDIY 120
Query: 121 MNNVIVRLSQISEDVIRLFKKSKEIGLQMHEELLKVTNELYTVMKTYHMYHAESISAESK 180
+NN+I R Q+SED RLFKKSKE+G Q+ ++L+KV NELY+VMKTYHMY+A+SISA+SK
Sbjct: 121 LNNIIPRFVQVSEDSGRLFKKSKEVGQQLQDDLMKVLNELYSVMKTYHMYNADSISAQSK 180
Query: 181 LKEAEKQEEKQFNKS-----------GDLSMNLLRHEDRPQRRSSVKKIEKMKEKRQAKY 229
LKEAEKQEEKQ KS D + N+ R E++ RRSSVKKIEKMKEKRQAKY
Sbjct: 181 LKEAEKQEEKQIGKSVKQEDRQTPRSPDSTANV-RIEEKHVRRSSVKKIEKMKEKRQAKY 239
Query: 230 SENKLKCTKARNDYLLNLAATNAAISKYYIHDVSDLID-CCDLGFHASLARTFRTYLSAE 288
+ENKLK KARN+YLL L ATNA++ KYYIHD+SDLID CCDLG+HASL R RT+LSAE
Sbjct: 240 TENKLKAIKARNEYLLALEATNASVFKYYIHDLSDLIDQCCDLGYHASLNRALRTFLSAE 299
Query: 289 YNLETSRHEGLDVIENAVDNLDSRSDKHTVMDMCNQVFCPPLKFEFQPHMGDEVCQVSAQ 348
NLE S+HEGLD IENAV+NLD+ SDK +M+M N VFCPP+KFEFQPHMGD Q+ AQ
Sbjct: 300 LNLEQSKHEGLDAIENAVENLDATSDKQRLMEMYNNVFCPPMKFEFQPHMGDMASQLCAQ 359
Query: 349 QPVQTELLMRYHQLQSRLATLKIENEEVRKTLDATMQTLQDMLTVEDFDVSDAFQHSRST 408
QPVQ+EL+ R QLQSRL+TLKIENEEV+KT++AT+QT+QD++TVEDFDVSD FQ+S S
Sbjct: 360 QPVQSELVQRCQQLQSRLSTLKIENEEVKKTMEATLQTIQDIVTVEDFDVSDCFQYSNSM 419
Query: 409 ESVKSAASETYMSKINIAKRRANQQETEMFYFTKFKEYVNGSNLITKLQAKHDLLKQTLG 468
ESVKS SET+MSK +IAKRRANQQETE FYFTK KEY+ G NLITKLQAKHDLL++TLG
Sbjct: 420 ESVKSTVSETFMSKPSIAKRRANQQETEQFYFTKMKEYLEGRNLITKLQAKHDLLQKTLG 479
Query: 469 EGERAECGTTRGRRNARTRNQDSGQAIPLVVESCIRYINLYGLQQQGIFRVPGSQVEVND 528
E +R +C + RR++ R QDS QAIPLVVESCIR+I+ +GLQ +GIFRV GSQVEVND
Sbjct: 480 ESQRTDC--SLARRSSTVRKQDSSQAIPLVVESCIRFISRHGLQHEGIFRVSGSQVEVND 537
Query: 529 IKNSFERGEDPLVDDQNERDINSVAGVLKLYFRGLENPLFPKERFQDLISTIKLENPAER 588
IKN+FERGEDPL DQN+ D++S+AGVLKLYFRGLE+PLFPK+ F DL++ + ++N ER
Sbjct: 538 IKNAFERGEDPLAGDQNDHDMDSIAGVLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQER 597
Query: 589 VHQIQQILVTLPRVVIVVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMHIPDGQDP 648
I+++L+ LP+ +++MRYLFAFLNHLSQ+S+ENMMDPYNLAICFGP+LM +P+G D
Sbjct: 598 ALHIRKVLLVLPKTTLIIMRYLFAFLNHLSQFSEENMMDPYNLAICFGPSLMSVPEGHDQ 657
Query: 649 VSCQAHINEVIKTIIIHHEAIFPSPRELEGPVYEKCMAGG--EEYCDSPHSEPGAIDEVD 706
VSCQAH+NE+IKTIII HE IFPSPRELEGPVY + GG E+YCDSPH E ++++
Sbjct: 658 VSCQAHVNELIKTIIIQHENIFPSPRELEGPVYSR---GGSMEDYCDSPHGETTSVEDST 714
Query: 707 HDNGTEPHTSDEEVEQIEAIAKFDYMGRSPRELSFKKGASLLLYHRASEDWWEGRHNGVD 766
D E HTSD+E E IEAIAKFDY+GR+ RELSFKKGASLLLY RAS+DWWEGRHNG+D
Sbjct: 715 QDVTAEHHTSDDECEPIEAIAKFDYVGRTARELSFKKGASLLLYQRASDDWWEGRHNGID 774
Query: 767 GLIPHQYIVVQDMDDAFSDSLSQKADSEASSGPLLDDKASSKNDLQSPT-EHISDYGFGG 825
GLIPHQYIVVQD +D + S K++ E S P ++K +++ P+ H++D
Sbjct: 775 GLIPHQYIVVQDTEDGVVERSSPKSEIEVISEP-PEEKVTARAGASCPSGGHVADIYLAN 833
Query: 826 VMGRVRLRSDGAAIPRRRSGGDTHSPPRGLGPSIDTPPRAAACPSSPHKIPLTRGRIESP 885
+ + R R + +I R+ D+H L S +P A+C S I E P
Sbjct: 834 I-NKQRKRPESGSI-RKTFRSDSHGLSSSLTDS-SSPGVGASCRPSSQPIMSQSLPKEGP 890
Query: 886 EKRRMATFGSAGSIN-YPDKKALSEGHSMRSTCGSTRHSSLGDHKSLEAEALAEDIEKTM 944
+K ++ GS SI+ + K + +R T + R S +H+ ++ E +A+DIE TM
Sbjct: 891 DKCSISGHGSLNSISRHSSLKNRLDSPQIRKTATAGRSKSFNNHRPMDPEVIAQDIEATM 950
Query: 945 STALHELRELERQNTVKQAPDVVLDTLEPLKNPPGPV-SSEPASPLHTIVIRDPDAAMRR 1003
++AL+ELRELERQ++VK PDVVLDTLEPLK P +SEP+SPLHT +++DP+ A +R
Sbjct: 951 NSALNELRELERQSSVKHTPDVVLDTLEPLKTSPVVAPTSEPSSPLHTQLLKDPEPAFQR 1010
Query: 1004 SSSSSTEMMTTFKPALSARLAGAQLRPPPMRPVRPVVQHRSSSSSSSGVGSPAVTPTEK 1062
S+S++ ++ F+P S ++A A ++PP RP +P V +++++S S + T+K
Sbjct: 1011 SASTAGDIACAFRPVKSVKMA-APVKPPATRP-KPTVFPKTNATSPGVNSSTSPQSTDK 1067
>gi|112363096 SLIT-ROBO Rho GTPase activating protein 2 isoform b
[Homo sapiens]
Length = 836
Score = 1119 bits (2894), Expect = 0.0
Identities = 559/835 (66%), Positives = 684/835 (81%), Gaps = 22/835 (2%)
Query: 1 MSSQTKFKKDKEIIAEYEAQIKEIRTQLVEQFKCLEQQSESRLQLLQDLQEFFRRKAEIE 60
M+S KFKKDKEIIAEY+ Q+KEIR QL EQ KCL+QQ E R+QLLQDLQ+FFR+KAEIE
Sbjct: 1 MTSPAKFKKDKEIIAEYDTQVKEIRAQLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIE 60
Query: 61 LEYSRSLEKLAERFSSKIRSSREHQFKKDQYLLSPVNCWYLVLHQTRRESRDHATLNDIF 120
++YSR+LEKLAERF +K RS+++ QFKKDQ +LSPVNCW L+L+Q +RESRDH TL+DI+
Sbjct: 61 MDYSRNLEKLAERFLAKTRSTKDQQFKKDQNVLSPVNCWNLLLNQVKRESRDHTTLSDIY 120
Query: 121 MNNVIVRLSQISEDVIRLFKKSKEIGLQMHEELLKVTNELYTVMKTYHMYHAESISAESK 180
+NN+I R Q+SED RLFKKSKE+G Q+ ++L+KV NELY+VMKTYHMY+A+SISA+SK
Sbjct: 121 LNNIIPRFVQVSEDSGRLFKKSKEVGQQLQDDLMKVLNELYSVMKTYHMYNADSISAQSK 180
Query: 181 LKEAEKQEEKQFNKS-----------GDLSMNLLRHEDRPQRRSSVKKIEKMKEKRQAKY 229
LKEAEKQEEKQ KS D + N+ R E++ RRSSVKKIEKMKEKRQAKY
Sbjct: 181 LKEAEKQEEKQIGKSVKQEDRQTPRSPDSTANV-RIEEKHVRRSSVKKIEKMKEKRQAKY 239
Query: 230 SENKLKCTKARNDYLLNLAATNAAISKYYIHDVSDLID-CCDLGFHASLARTFRTYLSAE 288
+ENKLK KARN+YLL L ATNA++ KYYIHD+SDLID CCDLG+HASL R RT+LSAE
Sbjct: 240 TENKLKAIKARNEYLLALEATNASVFKYYIHDLSDLIDQCCDLGYHASLNRALRTFLSAE 299
Query: 289 YNLETSRHEGLDVIENAVDNLDSRSDKHTVMDMCNQVFCPPLKFEFQPHMGDEVCQVSAQ 348
NLE S+HEGLD IENAV+NLD+ SDK +M+M N VFCPP+KFEFQPHMGD Q+ AQ
Sbjct: 300 LNLEQSKHEGLDAIENAVENLDATSDKQRLMEMYNNVFCPPMKFEFQPHMGDMASQLCAQ 359
Query: 349 QPVQTELLMRYHQLQSRLATLKIENEEVRKTLDATMQTLQDMLTVEDFDVSDAFQHSRST 408
QPVQ+EL+ R QLQSRL+TLKIENEEV+KT++AT+QT+QD++TVEDFDVSD FQ+S S
Sbjct: 360 QPVQSELVQRCQQLQSRLSTLKIENEEVKKTMEATLQTIQDIVTVEDFDVSDCFQYSNSM 419
Query: 409 ESVKSAASETYMSKINIAKRRANQQETEMFYFTKFKEYVNGSNLITKLQAKHDLLKQTLG 468
ESVKS SET+MSK +IAKRRANQQETE FYFTK KEY+ G NLITKLQAKHDLL++TLG
Sbjct: 420 ESVKSTVSETFMSKPSIAKRRANQQETEQFYFTKMKEYLEGRNLITKLQAKHDLLQKTLG 479
Query: 469 EGERAECGTTRGRRNARTRNQDSGQAIPLVVESCIRYINLYGLQQQGIFRVPGSQVEVND 528
E +R +C + RR++ R QDS QAIPLVVESCIR+I+ +GLQ +GIFRV GSQVEVND
Sbjct: 480 ESQRTDC--SLARRSSTVRKQDSSQAIPLVVESCIRFISRHGLQHEGIFRVSGSQVEVND 537
Query: 529 IKNSFERGEDPLVDDQNERDINSVAGVLKLYFRGLENPLFPKERFQDLISTIKLENPAER 588
IKN+FERGEDPL DQN+ D++S+AGVLKLYFRGLE+PLFPK+ F DL++ + ++N ER
Sbjct: 538 IKNAFERGEDPLAGDQNDHDMDSIAGVLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQER 597
Query: 589 VHQIQQILVTLPRVVIVVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMHIPDGQDP 648
I+++L+ LP+ +++MRYLFAFLNHLSQ+S+ENMMDPYNLAICFGP+LM +P+G D
Sbjct: 598 ALHIRKVLLVLPKTTLIIMRYLFAFLNHLSQFSEENMMDPYNLAICFGPSLMSVPEGHDQ 657
Query: 649 VSCQAHINEVIKTIIIHHEAIFPSPRELEGPVYEKCMAGG--EEYCDSPHSEPGAIDEVD 706
VSCQAH+NE+IKTIII HE IFPSPRELEGPVY + GG E+YCDSPH E ++++
Sbjct: 658 VSCQAHVNELIKTIIIQHENIFPSPRELEGPVYSR---GGSMEDYCDSPHGETTSVEDST 714
Query: 707 HDNGTEPHTSDEEVEQIEAIAKFDYMGRSPRELSFKKGASLLLYHRASEDWWEGRHNGVD 766
D E HTSD+E E IEAIAKFDY+GR+ RELSFKKGASLLLY RAS+DWWEGRHNG+D
Sbjct: 715 QDVTAEHHTSDDECEPIEAIAKFDYVGRTARELSFKKGASLLLYQRASDDWWEGRHNGID 774
Query: 767 GLIPHQYIVVQDMDDAFSDSLSQKADSEASSGPLLDDKASSKNDLQSPT-EHISD 820
GLIPHQYIVVQD +D + S K++ E S P ++K +++ P+ H++D
Sbjct: 775 GLIPHQYIVVQDTEDGVVERSSPKSEIEVISEP-PEEKVTARAGASCPSGGHVAD 828
>gi|156071465 Rho GTPase activating protein 4 [Homo sapiens]
Length = 946
Score = 763 bits (1971), Expect = 0.0
Identities = 398/806 (49%), Positives = 555/806 (68%), Gaps = 34/806 (4%)
Query: 1 MSSQTKFKKDKEIIAEYEAQIKEIRTQLVEQFKCLEQQSESRLQLLQDLQEFFRRKAEIE 60
M++ K ++++ + AEYE Q+KE+R QL EQ +CLE Q E R +LLQ+L EF RR+AE+E
Sbjct: 1 MAAHGKLRRERGLQAEYETQVKEMRWQLSEQLRCLELQGELRRELLQELAEFMRRRAEVE 60
Query: 61 LEYSRSLEKLAERFSSK---IRSSREHQ-FKKDQYLLSPVNCWYLVLHQTRRESRDHATL 116
LEYSR LEKLAERFSS+ + SSREHQ F+K+ LLSP++CW ++L TR++SR+ A L
Sbjct: 61 LEYSRGLEKLAERFSSRGGRLGSSREHQSFRKEPSLLSPLHCWAVLLQHTRQQSRESAAL 120
Query: 117 NDIFMNNVIVRLSQISEDVIRLFKKSKEIGLQMHEELLKVTNELYTVMKTYHMYHAESIS 176
+++ + RLS I+EDV RL KKS+++ Q+ +ELL+V +EL T KTY YH ES++
Sbjct: 121 SEVLAGPLAQRLSHIAEDVGRLVKKSRDLEQQLQDELLEVVSELQTAKKTYQAYHMESVN 180
Query: 177 AESKLKEAEKQEEKQFNKSGDLSMNLLRHEDRPQRRSSVKKIEKMKEKRQAKYSENKLKC 236
AE+KL+EAE+QEEK+ +S + E P R+SS+KK ++ EKRQAK+ E+KLKC
Sbjct: 181 AEAKLREAERQEEKRAGRSVPTT-TAGATEAGPLRKSSLKKGGRLVEKRQAKFMEHKLKC 239
Query: 237 TKARNDYLLNLAATNAAISKYYIHDVSDLIDCCDLGFHASLARTFRTYLSAEYNLETSRH 296
TKARN+YLL+LA+ NAA+S YY+HDV DL+DCCD GFH +L + R+Y +AE + S+
Sbjct: 240 TKARNEYLLSLASVNAAVSNYYLHDVLDLMDCCDTGFHLALGQVLRSYTAAESRTQASQV 299
Query: 297 EGLDVIENAVDNLDSRSDKHTVMDMCNQVFCPPLKFEFQPHMGDEVCQVSAQQPVQTELL 356
+GL +E AV+ LD DK V+++ VFCPPL+F++ PH GDEV ++ + ++ E+L
Sbjct: 300 QGLGSLEEAVEALDPPGDKAKVLEVHATVFCPPLRFDYHPHDGDEVAEICVEMELRDEIL 359
Query: 357 MRYHQLQSRLATLKIENEEVRKTLDATMQTLQDMLTVEDFDVSDAFQHSRSTESVKSAAS 416
R +QSRL IE EEV KTL AT+Q L +++ +D DV D+FQ S STES+KS +S
Sbjct: 360 PRAQNIQSRLDRQTIETEEVNKTLKATLQALLEVVASDDGDVLDSFQTSPSTESLKSTSS 419
Query: 417 ETYMSKINIAKRRANQQETEMFYFTKFKEYVNGSNLITKLQAKHDLLKQTLGEGERAECG 476
+ +RR QQETE FY TK +EY++G +++ KLQAKH+ L++ L G++ E
Sbjct: 420 DP--GSRQAGRRRGQQQETETFYLTKLQEYLSGRSILAKLQAKHEKLQEALQRGDKEEQE 477
Query: 477 TT----RGRRNARTRN--------------------QDSGQAIPLVVESCIRYINLYGLQ 512
+ R+ ++R Q SGQ +PLVVESCIR+INL GLQ
Sbjct: 478 VSWTQYTQRKFQKSRQPRPSSQYNQRLFGGDMEKFIQSSGQPVPLVVESCIRFINLNGLQ 537
Query: 513 QQGIFRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAGVLKLYFRGLENPLFPKER 572
+GIFRV G+Q+ V++I+++FERGEDPLV+ D++SVAGVLKLYFR LE PLFP +
Sbjct: 538 HEGIFRVSGAQLRVSEIRDAFERGEDPLVEGCTAHDLDSVAGVLKLYFRSLEPPLFPPDL 597
Query: 573 FQDLISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAFLNHLSQYSDENMMDPYNLA 632
F +L+++ +LE AERV + ++L LP V+VV+RYLF FLNHL+QYSDENMMDPYNLA
Sbjct: 598 FGELLASSELEATAERVEHVSRLLWRLPAPVLVVLRYLFTFLNHLAQYSDENMMDPYNLA 657
Query: 633 ICFGPTLMHIPDGQDPVSCQAHINEVIKTIIIHHEAIFPSPRELEGPVYEKCMAGGEEYC 692
+CFGPTL+ +P GQDPV+ Q +N++++T+I+ + +FP L GPVYEKCMA C
Sbjct: 658 VCFGPTLLPVPAGQDPVALQGRVNQLVQTLIVQPDRVFPPLTSLPGPVYEKCMAPPSASC 717
Query: 693 --DSPHSEPGAIDEVDHDNGTEPHTSDEEVEQIEAIAKFDYMGRSPRELSFKKGASLLLY 750
D+ GA +E + + P D+ +EA+A F Y GR+ +ELSF++G L L+
Sbjct: 718 LGDAQLESLGADNEPELE-AEMPAQEDDLEGVVEAVACFAYTGRTAQELSFRRGDVLRLH 776
Query: 751 HRASEDWWEGRHNGVDGLIPHQYIVV 776
RAS DWW G HNG+ GLIPH+YI +
Sbjct: 777 ERASSDWWRGEHNGMRGLIPHKYITL 802
>gi|34013590 Rho GTPase activating protein 2 [Homo sapiens]
Length = 698
Score = 117 bits (292), Expect = 8e-26
Identities = 80/271 (29%), Positives = 135/271 (49%), Gaps = 30/271 (11%)
Query: 496 PLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAGV 555
PL+VE C+ +I GL ++G+FR+PG V D+++SF+ GE PL D + D+++VA +
Sbjct: 173 PLLVEQCVDFIRERGLTEEGLFRMPGQANLVRDLQDSFDCGEKPLFD--STTDVHTVASL 230
Query: 556 LKLYFRGLENPLFPKERFQDLISTIKL--ENPAERVHQIQQILVTLPRVVIVVMRYLFAF 613
LKLY R L P+ P R++D +S +L ++ E ++ + + LP+ ++RY+ F
Sbjct: 231 LKLYLRELPEPVVPFARYEDFLSCAQLLTKDEGEGTLELAKQVSNLPQANYNLLRYICKF 290
Query: 614 LNHLSQYSDENMMDPYNLAICFGPTLMHIPDGQDPVSCQ---AHINEVIKTIIIHHEAIF 670
L+ + YS+ N M NLA FGP ++ P +DPV+ + + ++ +I H +F
Sbjct: 291 LDEVQAYSNVNKMSVQNLATVFGPNILR-PQVEDPVTIMEGTSLVQHLMTVLIRKHSQLF 349
Query: 671 PSPRELEGPVYEK----CMA--GGEEYCDSPHSEPG---------------AIDEVDHDN 709
+P EGP + C G EE EPG A+ +
Sbjct: 350 TAPVP-EGPTSPRGGLQCAVGWGSEEVTRDSQGEPGGPGLPAHRTSSLDGAAVAVLSRTA 408
Query: 710 GTEPHTSDEEVEQIEAIAKFDYMGRSPRELS 740
T P + ++++ + + R PR LS
Sbjct: 409 PTGPGSRCSPGKKVQTLPSWKSSFRQPRSLS 439
>gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]
Length = 1397
Score = 114 bits (285), Expect = 5e-25
Identities = 63/209 (30%), Positives = 117/209 (55%), Gaps = 7/209 (3%)
Query: 493 QAIPLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFERGEDPL-VDDQNERDINS 551
Q +PL+V +C R + GL+ GI+RVPG+ V+ ++ RG + + D+ +D+N
Sbjct: 823 QRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRGPGDINLQDERWQDLNV 882
Query: 552 VAGVLKLYFRGLENPLFPKERFQDLISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLF 611
++ +LK +FR L PLF +++ D I ++E+ ER+ +++++ LP +++L
Sbjct: 883 ISSLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARERMRTLRKLIRDLPGHYYETLKFLV 942
Query: 612 AFLNHLSQYSDENMMDPYNLAICFGPTLMHIPDGQ--DPVSCQAHINEVIKTIIIHHEAI 669
L ++ +S++N M+P NLA+ FGPTL+ + D V+ ++++T+I H +
Sbjct: 943 GHLKTIADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMPDRYKIVETLIQHSDWF 1002
Query: 670 FPSPRELEGPVYEKCMAGGEEYCDSPHSE 698
F S E +G E+ G +E P+ E
Sbjct: 1003 F-SDEEDKG---ERTPVGDKEPQAVPNIE 1027
>gi|111154090 Rho GTPase activating protein 24 isoform 3 [Homo
sapiens]
Length = 653
Score = 113 bits (283), Expect = 8e-25
Identities = 60/187 (32%), Positives = 110/187 (58%), Gaps = 8/187 (4%)
Query: 496 PLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAGV 555
P++VE C+ +I GL+++G+FR+PG V +++++F+ GE P D + D+++VA +
Sbjct: 58 PMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDAFDCGEKPSFD--SNTDVHTVASL 115
Query: 556 LKLYFRGLENPLFPKERFQDLISTIKLENPAER--VHQIQQILVTLPRVVIVVMRYLFAF 613
LKLY R L P+ P +++D +S KL + E V ++ + + +LP V +++Y+ F
Sbjct: 116 LKLYLRELPEPVIPYAKYEDFLSCAKLLSKEEEAGVKELAKQVKSLPVVNYNLLKYICRF 175
Query: 614 LNHLSQYSDENMMDPYNLAICFGPTLMHIPDGQDPVSCQ---AHINEVIKTIIIHHEAIF 670
L+ + YS N M NLA FGP ++ P +DP++ + +++ +I H+ +F
Sbjct: 176 LDEVQSYSGVNKMSVQNLATVFGPNILR-PKVEDPLTIMEGTVVVQQLMSVMISKHDCLF 234
Query: 671 PSPRELE 677
P EL+
Sbjct: 235 PKDAELQ 241
>gi|111154099 Rho GTPase activating protein 24 isoform 2 [Homo
sapiens]
Length = 655
Score = 113 bits (283), Expect = 8e-25
Identities = 60/187 (32%), Positives = 110/187 (58%), Gaps = 8/187 (4%)
Query: 496 PLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAGV 555
P++VE C+ +I GL+++G+FR+PG V +++++F+ GE P D + D+++VA +
Sbjct: 60 PMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDAFDCGEKPSFD--SNTDVHTVASL 117
Query: 556 LKLYFRGLENPLFPKERFQDLISTIKLENPAER--VHQIQQILVTLPRVVIVVMRYLFAF 613
LKLY R L P+ P +++D +S KL + E V ++ + + +LP V +++Y+ F
Sbjct: 118 LKLYLRELPEPVIPYAKYEDFLSCAKLLSKEEEAGVKELAKQVKSLPVVNYNLLKYICRF 177
Query: 614 LNHLSQYSDENMMDPYNLAICFGPTLMHIPDGQDPVSCQ---AHINEVIKTIIIHHEAIF 670
L+ + YS N M NLA FGP ++ P +DP++ + +++ +I H+ +F
Sbjct: 178 LDEVQSYSGVNKMSVQNLATVFGPNILR-PKVEDPLTIMEGTVVVQQLMSVMISKHDCLF 236
Query: 671 PSPRELE 677
P EL+
Sbjct: 237 PKDAELQ 243
>gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo
sapiens]
Length = 748
Score = 113 bits (283), Expect = 8e-25
Identities = 60/187 (32%), Positives = 110/187 (58%), Gaps = 8/187 (4%)
Query: 496 PLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAGV 555
P++VE C+ +I GL+++G+FR+PG V +++++F+ GE P D + D+++VA +
Sbjct: 153 PMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDAFDCGEKPSFD--SNTDVHTVASL 210
Query: 556 LKLYFRGLENPLFPKERFQDLISTIKLENPAER--VHQIQQILVTLPRVVIVVMRYLFAF 613
LKLY R L P+ P +++D +S KL + E V ++ + + +LP V +++Y+ F
Sbjct: 211 LKLYLRELPEPVIPYAKYEDFLSCAKLLSKEEEAGVKELAKQVKSLPVVNYNLLKYICRF 270
Query: 614 LNHLSQYSDENMMDPYNLAICFGPTLMHIPDGQDPVSCQ---AHINEVIKTIIIHHEAIF 670
L+ + YS N M NLA FGP ++ P +DP++ + +++ +I H+ +F
Sbjct: 271 LDEVQSYSGVNKMSVQNLATVFGPNILR-PKVEDPLTIMEGTVVVQQLMSVMISKHDCLF 329
Query: 671 PSPRELE 677
P EL+
Sbjct: 330 PKDAELQ 336
>gi|203097003 Rho GTPase activating protein 21 [Homo sapiens]
Length = 1958
Score = 111 bits (278), Expect = 3e-24
Identities = 56/179 (31%), Positives = 104/179 (58%), Gaps = 3/179 (1%)
Query: 495 IPLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFERG-EDPLVDDQNERDINSVA 553
IPL+V+ C + + GL+ GI+RVPG+ ++ ++ +G D + D RD+N ++
Sbjct: 1161 IPLIVDICCKLVEERGLEYTGIYRVPGNNAAISSMQEELNKGMADIDIQDDKWRDLNVIS 1220
Query: 554 GVLKLYFRGLENPLFPKERFQDLISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAF 613
+LK +FR L PLF +++ D I + E+P +R+ +++++ LP +++L A
Sbjct: 1221 SLLKSFFRKLPEPLFTNDKYADFIEANRKEDPLDRLKTLKRLIHDLPEHHYETLKFLSAH 1280
Query: 614 LNHLSQYSDENMMDPYNLAICFGPTLMHIPDGQ--DPVSCQAHINEVIKTIIIHHEAIF 670
L +++ S++N M+P NLAI FGPTL+ + V+ ++++T+I HH+ F
Sbjct: 1281 LKTVAENSEKNKMEPRNLAIVFGPTLVRTSEDNMTHMVTHMPDQYKIVETLIQHHDWFF 1339
>gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens]
Length = 459
Score = 107 bits (268), Expect = 5e-23
Identities = 59/164 (35%), Positives = 90/164 (54%), Gaps = 5/164 (3%)
Query: 496 PLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFER-GEDPLVDDQNERDINSVAG 554
P+VV+ CIR I GL +G++RV G + D+K +F+R GE + DIN + G
Sbjct: 282 PMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGEKADISVNMYEDINIITG 341
Query: 555 VLKLYFRGLENPLFPKERFQDLISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAFL 614
LKLYFR L PL + + I + K+ +P E++ + + L LP +RYL A L
Sbjct: 342 ALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEALKLLPPAHCETLRYLMAHL 401
Query: 615 NHLSQYSDENMMDPYNLAICFGPTLMHIPDGQDPVSCQAHINEV 658
++ + EN+M+ NL I FGPTLM P+ + A +N++
Sbjct: 402 KRVTLHEKENLMNAENLGIVFGPTLMRSPE----LDAMAALNDI 441
>gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens]
Length = 433
Score = 107 bits (268), Expect = 5e-23
Identities = 59/164 (35%), Positives = 90/164 (54%), Gaps = 5/164 (3%)
Query: 496 PLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFER-GEDPLVDDQNERDINSVAG 554
P+VV+ CIR I GL +G++RV G + D+K +F+R GE + DIN + G
Sbjct: 256 PMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGEKADISVNMYEDINIITG 315
Query: 555 VLKLYFRGLENPLFPKERFQDLISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAFL 614
LKLYFR L PL + + I + K+ +P E++ + + L LP +RYL A L
Sbjct: 316 ALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEALKLLPPAHCETLRYLMAHL 375
Query: 615 NHLSQYSDENMMDPYNLAICFGPTLMHIPDGQDPVSCQAHINEV 658
++ + EN+M+ NL I FGPTLM P+ + A +N++
Sbjct: 376 KRVTLHEKENLMNAENLGIVFGPTLMRSPE----LDAMAALNDI 415
>gi|4757980 beta chimerin isoform 2 [Homo sapiens]
Length = 468
Score = 106 bits (264), Expect = 1e-22
Identities = 59/176 (33%), Positives = 92/176 (52%), Gaps = 2/176 (1%)
Query: 496 PLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFER-GEDPLVDDQNERDINSVAG 554
P+VV+ CIR I GL+ +G++RV G + D+K +F+R GE + DIN + G
Sbjct: 291 PMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGEKADISANVYPDINIITG 350
Query: 555 VLKLYFRGLENPLFPKERFQDLISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAFL 614
LKLYFR L P+ + + I K+ N ER+ + ++L+ LP +RYL L
Sbjct: 351 ALKLYFRDLPIPVITYDTYSKFIDAAKISNADERLEAVHEVLMLLPPAHYETLRYLMIHL 410
Query: 615 NHLSQYSDENMMDPYNLAICFGPTLMHIPDGQDPVSC-QAHINEVIKTIIIHHEAI 669
++ +N M+ NL I FGPTLM P+ + ++I I+I +E +
Sbjct: 411 KKVTMNEKDNFMNAENLGIVFGPTLMRPPEDSTLTTLHDMRYQKLIVQILIENEDV 466
>gi|91106928 beta chimerin isoform 1 [Homo sapiens]
Length = 332
Score = 106 bits (264), Expect = 1e-22
Identities = 59/176 (33%), Positives = 92/176 (52%), Gaps = 2/176 (1%)
Query: 496 PLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFER-GEDPLVDDQNERDINSVAG 554
P+VV+ CIR I GL+ +G++RV G + D+K +F+R GE + DIN + G
Sbjct: 155 PMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGEKADISANVYPDINIITG 214
Query: 555 VLKLYFRGLENPLFPKERFQDLISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAFL 614
LKLYFR L P+ + + I K+ N ER+ + ++L+ LP +RYL L
Sbjct: 215 ALKLYFRDLPIPVITYDTYSKFIDAAKISNADERLEAVHEVLMLLPPAHYETLRYLMIHL 274
Query: 615 NHLSQYSDENMMDPYNLAICFGPTLMHIPDGQDPVSC-QAHINEVIKTIIIHHEAI 669
++ +N M+ NL I FGPTLM P+ + ++I I+I +E +
Sbjct: 275 KKVTMNEKDNFMNAENLGIVFGPTLMRPPEDSTLTTLHDMRYQKLIVQILIENEDV 330
>gi|226693398 Rho GTPase activating protein 27 isoform b [Homo
sapiens]
Length = 521
Score = 100 bits (248), Expect = 1e-20
Identities = 63/232 (27%), Positives = 112/232 (48%), Gaps = 16/232 (6%)
Query: 442 KFKEYVNGSNLITKLQAKHDLLKQTLGEGERAECGTTRGRRNARTRNQDSGQAIPLVVES 501
K ++++ + L+ K + Q G A C R R +P V+
Sbjct: 302 KLRKFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSR-------------VPRFVQQ 348
Query: 502 CIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAGVLKLYFR 561
CIR + GL G++R+ G+ + ++ + E +DD D++ + G LKL+FR
Sbjct: 349 CIRAVEARGLDIDGLYRISGNLATIQKLRYKVDHDERLDLDDGRWEDVHVITGALKLFFR 408
Query: 562 GLENPLFPKERFQDLISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAFLNHLSQYS 621
L PLFP F+ I+ IKL++ A R ++ ++ +LP +R LF L + ++
Sbjct: 409 ELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHG 468
Query: 622 DENMMDPYNLAICFGPTLM--HIPDGQDPVSCQAHINEVIKTIIIHHEAIFP 671
++N M ++AI FGPTL+ + + P++ N+V++ I+ IFP
Sbjct: 469 EQNRMSVQSVAIVFGPTLLRPEVEETSMPMT-MVFQNQVVELILQQCADIFP 519
>gi|40548322 Rho GTPase activating protein 27 isoform a [Homo
sapiens]
Length = 548
Score = 100 bits (248), Expect = 1e-20
Identities = 63/232 (27%), Positives = 112/232 (48%), Gaps = 16/232 (6%)
Query: 442 KFKEYVNGSNLITKLQAKHDLLKQTLGEGERAECGTTRGRRNARTRNQDSGQAIPLVVES 501
K ++++ + L+ K + Q G A C R R +P V+
Sbjct: 329 KLRKFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSR-------------VPRFVQQ 375
Query: 502 CIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAGVLKLYFR 561
CIR + GL G++R+ G+ + ++ + E +DD D++ + G LKL+FR
Sbjct: 376 CIRAVEARGLDIDGLYRISGNLATIQKLRYKVDHDERLDLDDGRWEDVHVITGALKLFFR 435
Query: 562 GLENPLFPKERFQDLISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAFLNHLSQYS 621
L PLFP F+ I+ IKL++ A R ++ ++ +LP +R LF L + ++
Sbjct: 436 ELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHG 495
Query: 622 DENMMDPYNLAICFGPTLM--HIPDGQDPVSCQAHINEVIKTIIIHHEAIFP 671
++N M ++AI FGPTL+ + + P++ N+V++ I+ IFP
Sbjct: 496 EQNRMSVQSVAIVFGPTLLRPEVEETSMPMT-MVFQNQVVELILQQCADIFP 546
>gi|150417981 glucocorticoid receptor DNA binding factor 1 [Homo
sapiens]
Length = 1499
Score = 99.4 bits (246), Expect = 2e-20
Identities = 53/152 (34%), Positives = 89/152 (58%), Gaps = 6/152 (3%)
Query: 495 IPLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFERGEDPLVDDQNERD--INSV 552
IP+ +E CI YI GL +GI+RV G++ E+ ++ F++ + D E+D +N+V
Sbjct: 1261 IPIFIERCIEYIEATGLSTEGIYRVSGNKSEMESLQRQFDQDHNL---DLAEKDFTVNTV 1317
Query: 553 AGVLKLYFRGLENPLFPKERFQDLISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFA 612
AG +K +F L +PL P DL+ K+ + +++H ++++L P+ V +Y+ +
Sbjct: 1318 AGAMKSFFSELPDPLVPYNMQIDLVEAHKINDREQKLHALKEVLKKFPKENHEVFKYVIS 1377
Query: 613 FLNHLSQYSDENMMDPYNLAICFGPTLMHIPD 644
LN +S + N+M NL+ICF PTLM PD
Sbjct: 1378 HLNKVSHNNKVNLMTSENLSICFWPTLMR-PD 1408
>gi|71834863 Rho GTPase activating protein 5 isoform a [Homo sapiens]
Length = 1502
Score = 99.0 bits (245), Expect = 2e-20
Identities = 58/175 (33%), Positives = 94/175 (53%), Gaps = 10/175 (5%)
Query: 495 IPLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAG 554
IPL VE C+ +I GL +G++RV G++ + ++I+ F++ + + E +N+VAG
Sbjct: 1274 IPLFVEKCVEFIEDTGLCTEGLYRVSGNKTDQDNIQKQFDQDHNINLVSM-EVTVNAVAG 1332
Query: 555 VLKLYFRGLENPLFPKERFQDLISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAFL 614
LK +F L +PL P +L+ K+ + ER+H +++I+ V V RY+ L
Sbjct: 1333 ALKAFFADLPDPLIPYSLHPELLEAAKIPDKTERLHALKEIVKKFHPVNYDVFRYVITHL 1392
Query: 615 NHLSQYSDENMMDPYNLAICFGPTLMHIPDGQDPVSCQAHINEVIKTIIIHHEAI 669
N +SQ N+M NL+ICF PTLM PD ++ E + T IH +
Sbjct: 1393 NRVSQQHKINLMTADNLSICFWPTLMR-PDFEN--------REFLSTTKIHQSVV 1438
>gi|71834861 Rho GTPase activating protein 5 isoform b [Homo sapiens]
Length = 1501
Score = 99.0 bits (245), Expect = 2e-20
Identities = 58/175 (33%), Positives = 94/175 (53%), Gaps = 10/175 (5%)
Query: 495 IPLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAG 554
IPL VE C+ +I GL +G++RV G++ + ++I+ F++ + + E +N+VAG
Sbjct: 1273 IPLFVEKCVEFIEDTGLCTEGLYRVSGNKTDQDNIQKQFDQDHNINLVSM-EVTVNAVAG 1331
Query: 555 VLKLYFRGLENPLFPKERFQDLISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAFL 614
LK +F L +PL P +L+ K+ + ER+H +++I+ V V RY+ L
Sbjct: 1332 ALKAFFADLPDPLIPYSLHPELLEAAKIPDKTERLHALKEIVKKFHPVNYDVFRYVITHL 1391
Query: 615 NHLSQYSDENMMDPYNLAICFGPTLMHIPDGQDPVSCQAHINEVIKTIIIHHEAI 669
N +SQ N+M NL+ICF PTLM PD ++ E + T IH +
Sbjct: 1392 NRVSQQHKINLMTADNLSICFWPTLMR-PDFEN--------REFLSTTKIHQSVV 1437
>gi|7382480 Rho GTPase activating protein 6 isoform 4 [Homo sapiens]
Length = 771
Score = 98.2 bits (243), Expect = 4e-20
Identities = 111/437 (25%), Positives = 183/437 (41%), Gaps = 64/437 (14%)
Query: 495 IPLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAG 554
+P +V+SC +++ +GLQ GIFRV S+ V ++ F+RG D V + E ++ VA
Sbjct: 207 VPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGID--VSLEEEHSVHDVAA 264
Query: 555 VLKLYFRGLENPLFPKERFQDLISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAFL 614
+LK + R + +PL +E + I+T+ LE P E++ +Q ++ LP + L FL
Sbjct: 265 LLKEFLRDMPDPLLTRELYTAFINTLLLE-PEEQLGTLQLLIYLLPPCNCDTLHRLLQFL 323
Query: 615 NHLSQYSDENM-----------MDPYNLAICFGPTLMHIPDGQD---PVSCQAHINE--- 657
+ +++++D+N+ M NLA FGP L+H D V A E
Sbjct: 324 SIVARHADDNISKDGQEVTGNKMTSLNLATIFGPNLLHKQKSSDKEFSVQSSARAEESTA 383
Query: 658 ---VIKTIIIHHEAIFPSPRELEGPVYEKCMAGGEEYCD-------SPHSEPGAI-DEVD 706
V++ +I ++EA+F P +L+ V + + D S S P + EV
Sbjct: 384 IIAVVQKMIENYEALFMVPPDLQNEVLISLLETDPDVVDYLLRRKASQSSSPDMLQSEVS 443
Query: 707 HDNGTEPHTSDEEVEQIEAIAKFDYMGRSPRELSFKKGASLLLYHRASEDWWEGRHNGVD 766
G ++D I+ +D SP + + L + A+ E +
Sbjct: 444 FSVGGRHSSTDSNKASSGDISPYD--NNSP---VLSERSLLAMQEDAAPGGSEKLYR--- 495
Query: 767 GLIPHQYIVVQDMDDAFSDSLSQKADSEASSGPLLDDKASSK---------NDLQSPTEH 817
+P Q+++V LS E+S GP L S + + L+S ++
Sbjct: 496 --VPGQFMLV--------GHLSSSKSRESSPGPRLGKDLSEEPFDIWGTWHSTLKSGSK- 544
Query: 818 ISDYGFGGVMGRVRLRSDGAAIPRRRSGGDTHSP--PRGLGPSIDTPPRAAACPSSPHKI 875
D G G G + S A P S G+ SP PR G + +
Sbjct: 545 --DPGMTGSSGDIFESSSLRAGPCSLSQGNL-SPNWPRWQGSPAELDSDTQGARRTQAAA 601
Query: 876 PLTRGRIESPEKRRMAT 892
P T GR R +T
Sbjct: 602 PATEGRAHPAVSRACST 618
>gi|95091875 Rho GTPase activating protein 6 isoform 1 [Homo
sapiens]
Length = 974
Score = 98.2 bits (243), Expect = 4e-20
Identities = 111/437 (25%), Positives = 183/437 (41%), Gaps = 64/437 (14%)
Query: 495 IPLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAG 554
+P +V+SC +++ +GLQ GIFRV S+ V ++ F+RG D V + E ++ VA
Sbjct: 410 VPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGID--VSLEEEHSVHDVAA 467
Query: 555 VLKLYFRGLENPLFPKERFQDLISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAFL 614
+LK + R + +PL +E + I+T+ LE P E++ +Q ++ LP + L FL
Sbjct: 468 LLKEFLRDMPDPLLTRELYTAFINTLLLE-PEEQLGTLQLLIYLLPPCNCDTLHRLLQFL 526
Query: 615 NHLSQYSDENM-----------MDPYNLAICFGPTLMHIPDGQD---PVSCQAHINE--- 657
+ +++++D+N+ M NLA FGP L+H D V A E
Sbjct: 527 SIVARHADDNISKDGQEVTGNKMTSLNLATIFGPNLLHKQKSSDKEFSVQSSARAEESTA 586
Query: 658 ---VIKTIIIHHEAIFPSPRELEGPVYEKCMAGGEEYCD-------SPHSEPGAI-DEVD 706
V++ +I ++EA+F P +L+ V + + D S S P + EV
Sbjct: 587 IIAVVQKMIENYEALFMVPPDLQNEVLISLLETDPDVVDYLLRRKASQSSSPDMLQSEVS 646
Query: 707 HDNGTEPHTSDEEVEQIEAIAKFDYMGRSPRELSFKKGASLLLYHRASEDWWEGRHNGVD 766
G ++D I+ +D SP + + L + A+ E +
Sbjct: 647 FSVGGRHSSTDSNKASSGDISPYD--NNSP---VLSERSLLAMQEDAAPGGSEKLYR--- 698
Query: 767 GLIPHQYIVVQDMDDAFSDSLSQKADSEASSGPLLDDKASSK---------NDLQSPTEH 817
+P Q+++V LS E+S GP L S + + L+S ++
Sbjct: 699 --VPGQFMLV--------GHLSSSKSRESSPGPRLGKDLSEEPFDIWGTWHSTLKSGSK- 747
Query: 818 ISDYGFGGVMGRVRLRSDGAAIPRRRSGGDTHSP--PRGLGPSIDTPPRAAACPSSPHKI 875
D G G G + S A P S G+ SP PR G + +
Sbjct: 748 --DPGMTGSSGDIFESSSLRAGPCSLSQGNL-SPNWPRWQGSPAELDSDTQGARRTQAAA 804
Query: 876 PLTRGRIESPEKRRMAT 892
P T GR R +T
Sbjct: 805 PATEGRAHPAVSRACST 821
>gi|95091988 Rho GTPase activating protein 6 isoform 3 [Homo
sapiens]
Length = 765
Score = 97.1 bits (240), Expect = 8e-20
Identities = 63/206 (30%), Positives = 108/206 (52%), Gaps = 23/206 (11%)
Query: 495 IPLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAG 554
+P +V+SC +++ +GLQ GIFRV S+ V ++ F+RG D V + E ++ VA
Sbjct: 410 VPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGID--VSLEEEHSVHDVAA 467
Query: 555 VLKLYFRGLENPLFPKERFQDLISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAFL 614
+LK + R + +PL +E + I+T+ LE P E++ +Q ++ LP + L FL
Sbjct: 468 LLKEFLRDMPDPLLTRELYTAFINTLLLE-PEEQLGTLQLLIYLLPPCNCDTLHRLLQFL 526
Query: 615 NHLSQYSDENM-----------MDPYNLAICFGPTLMHIPDGQD---PVSCQAHINE--- 657
+ +++++D+N+ M NLA FGP L+H D V A E
Sbjct: 527 SIVARHADDNISKDGQEVTGNKMTSLNLATIFGPNLLHKQKSSDKEFSVQSSARAEESTA 586
Query: 658 ---VIKTIIIHHEAIFPSPRELEGPV 680
V++ +I ++EA+F P +L+ V
Sbjct: 587 IIAVVQKMIENYEALFMVPPDLQNEV 612
>gi|4757766 Rho GTPase activating protein 1 [Homo sapiens]
Length = 439
Score = 94.0 bits (232), Expect = 7e-19
Identities = 55/181 (30%), Positives = 92/181 (50%), Gaps = 3/181 (1%)
Query: 493 QAIPLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSV 552
+ IP+V+ + Y+ + L +GIFR + V +++ + G D NE + +V
Sbjct: 257 EPIPIVLRETVAYLQAHALTTEGIFRRSANTQVVREVQQKYNMGLPVDFDQYNELHLPAV 316
Query: 553 AGVLKLYFRGLENPLFPKERFQDLISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFA 612
+LK + R L PL + + ++ + ++ ++RV Q+L TLP V+R+L A
Sbjct: 317 --ILKTFLRELPEPLLTFDLYPHVVGFLNIDE-SQRVPATLQVLQTLPEENYQVLRFLTA 373
Query: 613 FLNHLSQYSDENMMDPYNLAICFGPTLMHIPDGQDPVSCQAHINEVIKTIIIHHEAIFPS 672
FL +S +SD+N M NLA+ FGP L+ D + IN K ++ H +FPS
Sbjct: 374 FLVQISAHSDQNKMTNTNLAVVFGPNLLWAKDAAITLKAINPINTFTKFLLDHQGELFPS 433
Query: 673 P 673
P
Sbjct: 434 P 434
>gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens]
Length = 1227
Score = 93.6 bits (231), Expect = 9e-19
Identities = 46/146 (31%), Positives = 79/146 (54%)
Query: 495 IPLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAG 554
+P +V C+ I G+++ GI+RV G ++ +K +F+ + +E D+N++AG
Sbjct: 1023 VPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNKDVSVMMSEMDVNAIAG 1082
Query: 555 VLKLYFRGLENPLFPKERFQDLISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAFL 614
LKLYFR L PLF E + + I L +P + + +L++LP ++ +L L
Sbjct: 1083 TLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLLLSLPEANLLTFLFLLDHL 1142
Query: 615 NHLSQYSDENMMDPYNLAICFGPTLM 640
+++ N M +NLA FGPTL+
Sbjct: 1143 KRVAEKEAVNKMSLHNLATVFGPTLL 1168
>gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens]
Length = 1271
Score = 93.6 bits (231), Expect = 9e-19
Identities = 46/146 (31%), Positives = 79/146 (54%)
Query: 495 IPLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAG 554
+P +V C+ I G+++ GI+RV G ++ +K +F+ + +E D+N++AG
Sbjct: 1067 VPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNKDVSVMMSEMDVNAIAG 1126
Query: 555 VLKLYFRGLENPLFPKERFQDLISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAFL 614
LKLYFR L PLF E + + I L +P + + +L++LP ++ +L L
Sbjct: 1127 TLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLLLSLPEANLLTFLFLLDHL 1186
Query: 615 NHLSQYSDENMMDPYNLAICFGPTLM 640
+++ N M +NLA FGPTL+
Sbjct: 1187 KRVAEKEAVNKMSLHNLATVFGPTLL 1212
>gi|26986534 Rho GTPase activating protein 12 [Homo sapiens]
Length = 846
Score = 92.4 bits (228), Expect = 2e-18
Identities = 52/183 (28%), Positives = 95/183 (51%), Gaps = 2/183 (1%)
Query: 489 QDSGQAIPLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFERGEDPLVDDQNERD 548
Q +P V+ CI ++ +GL GI+RV G+ + ++ + E ++D D
Sbjct: 663 QRENGTVPKFVKLCIEHVEEHGLDIDGIYRVSGNLAVIQKLRFAVNHDEKLDLNDSKWED 722
Query: 549 INSVAGVLKLYFRGLENPLFPKERFQDLISTIKLENPAERVHQIQQILVTLPRVVIVVMR 608
I+ + G LK++FR L PLF F D ++ IK E P +RV ++ ++ LP+ M+
Sbjct: 723 IHVITGALKMFFRELPEPLFTFNHFNDFVNAIKQE-PRQRVAAVKDLIRQLPKPNQDTMQ 781
Query: 609 YLFAFLNHLSQYSDENMMDPYNLAICFGPTLMHIPDGQDPVSCQ-AHINEVIKTIIIHHE 667
LF L + + ++N M ++AI FGPTL+ ++ + N++++ I++
Sbjct: 782 ILFRHLRRVIENGEKNRMTYQSIAIVFGPTLLKPEKETGNIAVHTVYQNQIVELILLELS 841
Query: 668 AIF 670
+IF
Sbjct: 842 SIF 844
>gi|188497642 ARHGAP15 [Homo sapiens]
Length = 475
Score = 90.9 bits (224), Expect = 6e-18
Identities = 57/236 (24%), Positives = 105/236 (44%), Gaps = 14/236 (5%)
Query: 441 TKFKEYVNGSNLITKLQAKHDLLKQTLGEGERAECGTTRGRRNARTRNQDSGQAIPLVVE 500
++ K+++ + LQ K + Q G C + +P V+
Sbjct: 253 SRLKKFITRRPSLKTLQEKGLIKDQIFGSHLHKVC-------------ERENSTVPWFVK 299
Query: 501 SCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAGVLKLYF 560
CI + GL GI+RV G+ + ++ + E +DD DI+ V G LK++F
Sbjct: 300 QCIEAVEKRGLDVDGIYRVSGNLATIQKLRFIVNQEEKLNLDDSQWEDIHVVTGALKMFF 359
Query: 561 RGLENPLFPKERFQDLISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAFLNHLSQY 620
R L PLFP F+ + IK ++ R+ ++ ++ LP M+ LF L +
Sbjct: 360 RELPEPLFPYSFFEQFVEAIKKQDNNTRIEAVKSLVQKLPPPNRDTMKVLFGHLTKIVAK 419
Query: 621 SDENMMDPYNLAICFGPTLMHIPDGQDPVSC-QAHINEVIKTIIIHHEAIFPSPRE 675
+ +N+M +L I FGPTL+ + ++ + N++ + ++ + IF S +
Sbjct: 420 ASKNLMSTQSLGIVFGPTLLRAENETGNMAIHMVYQNQIAELMLSEYSKIFGSEED 475
>gi|91208437 GEM interacting protein [Homo sapiens]
Length = 970
Score = 89.7 bits (221), Expect = 1e-17
Identities = 75/253 (29%), Positives = 115/253 (45%), Gaps = 30/253 (11%)
Query: 489 QDSGQAIPLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFERGEDPLVDDQNERD 548
+D + +P VV C I L QGI+RV GS+V V + +FE G + + +
Sbjct: 558 RDFPEEVPFVVTKCTAEIEHRALDVQGIYRVSGSRVRVERLCQAFENGR--ALVELSGNS 615
Query: 549 INSVAGVLKLYFRGLENPLFPKERFQDLISTIKL------ENPA------ERVHQIQQIL 596
+ V+ VLK + + L P+ P + IS K ++P E + ++ +L
Sbjct: 616 PHDVSSVLKRFLQELTEPVIPFHLYDAFISLAKTLHADPGDDPGTPSPSPEVIRSLKTLL 675
Query: 597 VTLPRVVIVVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMHIPDGQD-----PVSC 651
V LP +R+L A L ++ EN M NL I FGPTL+ PDG PV+C
Sbjct: 676 VQLPDSNYNTLRHLVAHLFRVAARFMENKMSANNLGIVFGPTLLRPPDGPRAASAIPVTC 735
Query: 652 ---QAHINEVIKTIIIHHEAIF---PSPRELEGPVYEKCMAGGEEYCDS----PHSEPGA 701
H ++++ +I+H+E IF P+ E P + A G S PH +P +
Sbjct: 736 LLDSGHQAQLVEFLIVHYEQIFGMDELPQATEPPPQDSSPAPGPLTTSSQPPPPHLDPDS 795
Query: 702 IDEV-DHDNGTEP 713
V D G +P
Sbjct: 796 QPPVLASDPGPDP 808
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.130 0.370
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,345,949
Number of Sequences: 37866
Number of extensions: 1922855
Number of successful extensions: 11171
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 249
Number of HSP's successfully gapped in prelim test: 391
Number of HSP's that attempted gapping in prelim test: 9660
Number of HSP's gapped (non-prelim): 1794
length of query: 1075
length of database: 18,247,518
effective HSP length: 113
effective length of query: 962
effective length of database: 13,968,660
effective search space: 13437850920
effective search space used: 13437850920
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.