Search of human proteins with 74136547

Search of human proteins with 74136547

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|74136547 Rho guanine nucleotide exchange factor (GEF)
10-like isoform 2 [Homo sapiens]
         (1240 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|74136547 Rho guanine nucleotide exchange factor (GEF) 10-like...  2492   0.0  
gi|58761492 Rho guanine nucleotide exchange factor (GEF) 10-like...  2473   0.0  
gi|62548864 Rho guanine nucleotide exchange factor 10 [Homo sapi...   890   0.0  
gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17 [Hom...   162   2e-39
gi|94557295 mitogen-activated protein kinase 8 interacting prote...   112   2e-24
gi|94557297 mitogen-activated protein kinase 8 interacting prote...   112   2e-24
gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens]        105   3e-22
gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens]        105   3e-22
gi|21735572 epithelial cell transforming sequence 2 oncogene pro...   103   1e-21
gi|194578923 sperm associated antigen 9 isoform 1 [Homo sapiens]      103   1e-21
gi|27436920 sperm associated antigen 9 isoform 3 [Homo sapiens]       103   1e-21
gi|229094128 active breakpoint cluster region-related  protein i...    94   1e-18
gi|38679957 active breakpoint cluster region-related  protein is...    94   1e-18
gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent R...    91   7e-18
gi|38679954 active breakpoint cluster region-related  protein is...    91   7e-18
gi|134133248 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]    87   1e-16
gi|134133265 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]    87   1e-16
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]                86   3e-16
gi|118150678 epithelial cell transforming sequence 2 oncogene-li...    84   6e-16
gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens]    84   8e-16
gi|164565408 common-site lymphoma/leukemia guanine nucleotide ex...    84   8e-16
gi|24797153 faciogenital dysplasia protein [Homo sapiens]              83   2e-15
gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens]    79   4e-14
gi|45439359 triple functional domain (PTPRF interacting) [Homo s...    79   4e-14
gi|154240686 FYVE, RhoGEF and PH domain containing 6 [Homo sapiens]    79   4e-14
gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a [...    76   2e-13
gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b [...    76   2e-13
gi|224586880 Ras protein-specific guanine nucleotide-releasing f...    74   7e-13
gi|24797099 Ras protein-specific guanine nucleotide-releasing fa...    74   7e-13
gi|71274148 pleckstrin homology domain containing, family G (wit...    73   1e-12

>gi|74136547 Rho guanine nucleotide exchange factor (GEF) 10-like
            isoform 2 [Homo sapiens]
          Length = 1240

 Score = 2492 bits (6459), Expect = 0.0
 Identities = 1240/1240 (100%), Positives = 1240/1240 (100%)

Query: 1    MASSNPPPQPAIGDQLVPGVPGPSSEAEDDPGEAFEFDDSDDEEDTSAALGVPSLAPERD 60
            MASSNPPPQPAIGDQLVPGVPGPSSEAEDDPGEAFEFDDSDDEEDTSAALGVPSLAPERD
Sbjct: 1    MASSNPPPQPAIGDQLVPGVPGPSSEAEDDPGEAFEFDDSDDEEDTSAALGVPSLAPERD 60

Query: 61   TDPPLIHLDSIPVTDPDPAAAPPGTGVPAWVSNGDAADAAFSGARHSSWKRKSSRRIDRF 120
            TDPPLIHLDSIPVTDPDPAAAPPGTGVPAWVSNGDAADAAFSGARHSSWKRKSSRRIDRF
Sbjct: 61   TDPPLIHLDSIPVTDPDPAAAPPGTGVPAWVSNGDAADAAFSGARHSSWKRKSSRRIDRF 120

Query: 121  TFPALEEDVIYDDVPCESPDAHQPGAERNLLYEDAHRAGAPRQAEDLGWSSSEFESYSED 180
            TFPALEEDVIYDDVPCESPDAHQPGAERNLLYEDAHRAGAPRQAEDLGWSSSEFESYSED
Sbjct: 121  TFPALEEDVIYDDVPCESPDAHQPGAERNLLYEDAHRAGAPRQAEDLGWSSSEFESYSED 180

Query: 181  SGEEAKPEVEVEPAKHRVSFQPKMTQLMKAAKSGTKDGLEKTRMAVMRKVSFLHRKDVLG 240
            SGEEAKPEVEVEPAKHRVSFQPKMTQLMKAAKSGTKDGLEKTRMAVMRKVSFLHRKDVLG
Sbjct: 181  SGEEAKPEVEVEPAKHRVSFQPKMTQLMKAAKSGTKDGLEKTRMAVMRKVSFLHRKDVLG 240

Query: 241  DSEEEDMGLLEVSVSDIKPPAPELGPMPEGLSPQQVVRRHILGSIVQSEGSYVESLKRIL 300
            DSEEEDMGLLEVSVSDIKPPAPELGPMPEGLSPQQVVRRHILGSIVQSEGSYVESLKRIL
Sbjct: 241  DSEEEDMGLLEVSVSDIKPPAPELGPMPEGLSPQQVVRRHILGSIVQSEGSYVESLKRIL 300

Query: 301  QDYRNPLMEMEPKALSARKCQVVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVA 360
            QDYRNPLMEMEPKALSARKCQVVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVA
Sbjct: 301  QDYRNPLMEMEPKALSARKCQVVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVA 360

Query: 361  SFSKSMVLDVYSDYVNNFTSAMSIIKKACLTKPAFLEFLKRRQVCSPDRVTLYGLMVKPI 420
            SFSKSMVLDVYSDYVNNFTSAMSIIKKACLTKPAFLEFLKRRQVCSPDRVTLYGLMVKPI
Sbjct: 361  SFSKSMVLDVYSDYVNNFTSAMSIIKKACLTKPAFLEFLKRRQVCSPDRVTLYGLMVKPI 420

Query: 421  QRFPQFILLLQDMLKNTPRGHPDRLSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKS 480
            QRFPQFILLLQDMLKNTPRGHPDRLSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKS
Sbjct: 421  QRFPQFILLLQDMLKNTPRGHPDRLSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKS 480

Query: 481  VSDRSSLNKLLTSGQRQLLLCETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKPA 540
            VSDRSSLNKLLTSGQRQLLLCETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKPA
Sbjct: 481  VSDRSSLNKLLTSGQRQLLLCETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKPA 540

Query: 541  NHRGQLEISSLVPLGPKYVVKWNTALPQVQVVEVGQDGGTYDKDNVLIQHSGAKKASASG 600
            NHRGQLEISSLVPLGPKYVVKWNTALPQVQVVEVGQDGGTYDKDNVLIQHSGAKKASASG
Sbjct: 541  NHRGQLEISSLVPLGPKYVVKWNTALPQVQVVEVGQDGGTYDKDNVLIQHSGAKKASASG 600

Query: 601  QAQNKVYLGPPRLFQELQDLQKDLAVVEQITLLISTLHGTYQNLNMTVAQDWCLALQRLM 660
            QAQNKVYLGPPRLFQELQDLQKDLAVVEQITLLISTLHGTYQNLNMTVAQDWCLALQRLM
Sbjct: 601  QAQNKVYLGPPRLFQELQDLQKDLAVVEQITLLISTLHGTYQNLNMTVAQDWCLALQRLM 660

Query: 661  RVKEEEIHSANKCRLRLLLPGKPDKSGRPISFMVVFITPNPLSKISWVNRLHLAKIGLRE 720
            RVKEEEIHSANKCRLRLLLPGKPDKSGRPISFMVVFITPNPLSKISWVNRLHLAKIGLRE
Sbjct: 661  RVKEEEIHSANKCRLRLLLPGKPDKSGRPISFMVVFITPNPLSKISWVNRLHLAKIGLRE 720

Query: 721  ENQPGWLCPDEDKKSKAPFWCPILACCIPAFSSRALSLQLGALVHSPVNCPLLGFSAVST 780
            ENQPGWLCPDEDKKSKAPFWCPILACCIPAFSSRALSLQLGALVHSPVNCPLLGFSAVST
Sbjct: 721  ENQPGWLCPDEDKKSKAPFWCPILACCIPAFSSRALSLQLGALVHSPVNCPLLGFSAVST 780

Query: 781  SLPQGYLWVGGGQEGAGGQVEIFSLNRPSPRTVKSFPLAAPVLCMEYIPELEEEAESRDE 840
            SLPQGYLWVGGGQEGAGGQVEIFSLNRPSPRTVKSFPLAAPVLCMEYIPELEEEAESRDE
Sbjct: 781  SLPQGYLWVGGGQEGAGGQVEIFSLNRPSPRTVKSFPLAAPVLCMEYIPELEEEAESRDE 840

Query: 841  SPTVADPSATVHPTICLGLQDGSILLYSSVDTGTQCLVSCRSPGLQPVLCLRHSPFHLLA 900
            SPTVADPSATVHPTICLGLQDGSILLYSSVDTGTQCLVSCRSPGLQPVLCLRHSPFHLLA
Sbjct: 841  SPTVADPSATVHPTICLGLQDGSILLYSSVDTGTQCLVSCRSPGLQPVLCLRHSPFHLLA 900

Query: 901  GLQDGTLAAYPRTSGGVLWDLESPPVCLTVGPGPVRTLLSLEDAVWASCGPRVTVLEATT 960
            GLQDGTLAAYPRTSGGVLWDLESPPVCLTVGPGPVRTLLSLEDAVWASCGPRVTVLEATT
Sbjct: 901  GLQDGTLAAYPRTSGGVLWDLESPPVCLTVGPGPVRTLLSLEDAVWASCGPRVTVLEATT 960

Query: 961  LQPQQSFEAHQDEAVSVTHMVKAGSGVWMAFSSGTSIRLFHTETLEHLQEINIATRTTFL 1020
            LQPQQSFEAHQDEAVSVTHMVKAGSGVWMAFSSGTSIRLFHTETLEHLQEINIATRTTFL
Sbjct: 961  LQPQQSFEAHQDEAVSVTHMVKAGSGVWMAFSSGTSIRLFHTETLEHLQEINIATRTTFL 1020

Query: 1021 LPGQKHLCVTSLLICQGLLWVGTDQGVIVLLPVPRLEGIPKITGKGMVSLNGHCGPVAFL 1080
            LPGQKHLCVTSLLICQGLLWVGTDQGVIVLLPVPRLEGIPKITGKGMVSLNGHCGPVAFL
Sbjct: 1021 LPGQKHLCVTSLLICQGLLWVGTDQGVIVLLPVPRLEGIPKITGKGMVSLNGHCGPVAFL 1080

Query: 1081 AVATSILAPDILRSDQEEAEGPRAEEDKPDGQAHEPMPDSHVGRELTRKKGILLQYRLRS 1140
            AVATSILAPDILRSDQEEAEGPRAEEDKPDGQAHEPMPDSHVGRELTRKKGILLQYRLRS
Sbjct: 1081 AVATSILAPDILRSDQEEAEGPRAEEDKPDGQAHEPMPDSHVGRELTRKKGILLQYRLRS 1140

Query: 1141 TAHLPGPLLSMREPAPADGAALEHSEEDGSIYEMADDPDIWVRSRPCARDAHRKEICSVA 1200
            TAHLPGPLLSMREPAPADGAALEHSEEDGSIYEMADDPDIWVRSRPCARDAHRKEICSVA
Sbjct: 1141 TAHLPGPLLSMREPAPADGAALEHSEEDGSIYEMADDPDIWVRSRPCARDAHRKEICSVA 1200

Query: 1201 IISGGQGYRNFGSALGSSGRQAPCGETDSTLLIWQVPLML 1240
            IISGGQGYRNFGSALGSSGRQAPCGETDSTLLIWQVPLML
Sbjct: 1201 IISGGQGYRNFGSALGSSGRQAPCGETDSTLLIWQVPLML 1240


>gi|58761492 Rho guanine nucleotide exchange factor (GEF) 10-like
            isoform 1 [Homo sapiens]
          Length = 1279

 Score = 2473 bits (6409), Expect = 0.0
 Identities = 1240/1279 (96%), Positives = 1240/1279 (96%), Gaps = 39/1279 (3%)

Query: 1    MASSNPPPQPAIGDQLVPGVPGPSSEAEDDPGEAFEFDDSDDEEDTSAALGVPSLAPERD 60
            MASSNPPPQPAIGDQLVPGVPGPSSEAEDDPGEAFEFDDSDDEEDTSAALGVPSLAPERD
Sbjct: 1    MASSNPPPQPAIGDQLVPGVPGPSSEAEDDPGEAFEFDDSDDEEDTSAALGVPSLAPERD 60

Query: 61   TDPPLIHLDSIPVTDPDPAAAPPGTGVPAWVSNGDAADAAFSGARHSSWKRKSSRRIDRF 120
            TDPPLIHLDSIPVTDPDPAAAPPGTGVPAWVSNGDAADAAFSGARHSSWKRKSSRRIDRF
Sbjct: 61   TDPPLIHLDSIPVTDPDPAAAPPGTGVPAWVSNGDAADAAFSGARHSSWKRKSSRRIDRF 120

Query: 121  TFPALEEDVIYDDVPCESPDAHQPGAERNLLYEDAHRAGAPRQAEDLGWSSSEFESYSED 180
            TFPALEEDVIYDDVPCESPDAHQPGAERNLLYEDAHRAGAPRQAEDLGWSSSEFESYSED
Sbjct: 121  TFPALEEDVIYDDVPCESPDAHQPGAERNLLYEDAHRAGAPRQAEDLGWSSSEFESYSED 180

Query: 181  SGEEAKPEVEVEPAKHRVSFQPK------------------------------------- 203
            SGEEAKPEVEVEPAKHRVSFQPK                                     
Sbjct: 181  SGEEAKPEVEVEPAKHRVSFQPKLSPDLTRLKERYARTKRDILALRVGGRDMQELKHKYD 240

Query: 204  --MTQLMKAAKSGTKDGLEKTRMAVMRKVSFLHRKDVLGDSEEEDMGLLEVSVSDIKPPA 261
              MTQLMKAAKSGTKDGLEKTRMAVMRKVSFLHRKDVLGDSEEEDMGLLEVSVSDIKPPA
Sbjct: 241  CKMTQLMKAAKSGTKDGLEKTRMAVMRKVSFLHRKDVLGDSEEEDMGLLEVSVSDIKPPA 300

Query: 262  PELGPMPEGLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQ 321
            PELGPMPEGLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQ
Sbjct: 301  PELGPMPEGLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQ 360

Query: 322  VVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSA 381
            VVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSA
Sbjct: 361  VVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSA 420

Query: 382  MSIIKKACLTKPAFLEFLKRRQVCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGH 441
            MSIIKKACLTKPAFLEFLKRRQVCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGH
Sbjct: 421  MSIIKKACLTKPAFLEFLKRRQVCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGH 480

Query: 442  PDRLSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLC 501
            PDRLSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLC
Sbjct: 481  PDRLSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLC 540

Query: 502  ETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKPANHRGQLEISSLVPLGPKYVVK 561
            ETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKPANHRGQLEISSLVPLGPKYVVK
Sbjct: 541  ETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKPANHRGQLEISSLVPLGPKYVVK 600

Query: 562  WNTALPQVQVVEVGQDGGTYDKDNVLIQHSGAKKASASGQAQNKVYLGPPRLFQELQDLQ 621
            WNTALPQVQVVEVGQDGGTYDKDNVLIQHSGAKKASASGQAQNKVYLGPPRLFQELQDLQ
Sbjct: 601  WNTALPQVQVVEVGQDGGTYDKDNVLIQHSGAKKASASGQAQNKVYLGPPRLFQELQDLQ 660

Query: 622  KDLAVVEQITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHSANKCRLRLLLPG 681
            KDLAVVEQITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHSANKCRLRLLLPG
Sbjct: 661  KDLAVVEQITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHSANKCRLRLLLPG 720

Query: 682  KPDKSGRPISFMVVFITPNPLSKISWVNRLHLAKIGLREENQPGWLCPDEDKKSKAPFWC 741
            KPDKSGRPISFMVVFITPNPLSKISWVNRLHLAKIGLREENQPGWLCPDEDKKSKAPFWC
Sbjct: 721  KPDKSGRPISFMVVFITPNPLSKISWVNRLHLAKIGLREENQPGWLCPDEDKKSKAPFWC 780

Query: 742  PILACCIPAFSSRALSLQLGALVHSPVNCPLLGFSAVSTSLPQGYLWVGGGQEGAGGQVE 801
            PILACCIPAFSSRALSLQLGALVHSPVNCPLLGFSAVSTSLPQGYLWVGGGQEGAGGQVE
Sbjct: 781  PILACCIPAFSSRALSLQLGALVHSPVNCPLLGFSAVSTSLPQGYLWVGGGQEGAGGQVE 840

Query: 802  IFSLNRPSPRTVKSFPLAAPVLCMEYIPELEEEAESRDESPTVADPSATVHPTICLGLQD 861
            IFSLNRPSPRTVKSFPLAAPVLCMEYIPELEEEAESRDESPTVADPSATVHPTICLGLQD
Sbjct: 841  IFSLNRPSPRTVKSFPLAAPVLCMEYIPELEEEAESRDESPTVADPSATVHPTICLGLQD 900

Query: 862  GSILLYSSVDTGTQCLVSCRSPGLQPVLCLRHSPFHLLAGLQDGTLAAYPRTSGGVLWDL 921
            GSILLYSSVDTGTQCLVSCRSPGLQPVLCLRHSPFHLLAGLQDGTLAAYPRTSGGVLWDL
Sbjct: 901  GSILLYSSVDTGTQCLVSCRSPGLQPVLCLRHSPFHLLAGLQDGTLAAYPRTSGGVLWDL 960

Query: 922  ESPPVCLTVGPGPVRTLLSLEDAVWASCGPRVTVLEATTLQPQQSFEAHQDEAVSVTHMV 981
            ESPPVCLTVGPGPVRTLLSLEDAVWASCGPRVTVLEATTLQPQQSFEAHQDEAVSVTHMV
Sbjct: 961  ESPPVCLTVGPGPVRTLLSLEDAVWASCGPRVTVLEATTLQPQQSFEAHQDEAVSVTHMV 1020

Query: 982  KAGSGVWMAFSSGTSIRLFHTETLEHLQEINIATRTTFLLPGQKHLCVTSLLICQGLLWV 1041
            KAGSGVWMAFSSGTSIRLFHTETLEHLQEINIATRTTFLLPGQKHLCVTSLLICQGLLWV
Sbjct: 1021 KAGSGVWMAFSSGTSIRLFHTETLEHLQEINIATRTTFLLPGQKHLCVTSLLICQGLLWV 1080

Query: 1042 GTDQGVIVLLPVPRLEGIPKITGKGMVSLNGHCGPVAFLAVATSILAPDILRSDQEEAEG 1101
            GTDQGVIVLLPVPRLEGIPKITGKGMVSLNGHCGPVAFLAVATSILAPDILRSDQEEAEG
Sbjct: 1081 GTDQGVIVLLPVPRLEGIPKITGKGMVSLNGHCGPVAFLAVATSILAPDILRSDQEEAEG 1140

Query: 1102 PRAEEDKPDGQAHEPMPDSHVGRELTRKKGILLQYRLRSTAHLPGPLLSMREPAPADGAA 1161
            PRAEEDKPDGQAHEPMPDSHVGRELTRKKGILLQYRLRSTAHLPGPLLSMREPAPADGAA
Sbjct: 1141 PRAEEDKPDGQAHEPMPDSHVGRELTRKKGILLQYRLRSTAHLPGPLLSMREPAPADGAA 1200

Query: 1162 LEHSEEDGSIYEMADDPDIWVRSRPCARDAHRKEICSVAIISGGQGYRNFGSALGSSGRQ 1221
            LEHSEEDGSIYEMADDPDIWVRSRPCARDAHRKEICSVAIISGGQGYRNFGSALGSSGRQ
Sbjct: 1201 LEHSEEDGSIYEMADDPDIWVRSRPCARDAHRKEICSVAIISGGQGYRNFGSALGSSGRQ 1260

Query: 1222 APCGETDSTLLIWQVPLML 1240
            APCGETDSTLLIWQVPLML
Sbjct: 1261 APCGETDSTLLIWQVPLML 1279


>gi|62548864 Rho guanine nucleotide exchange factor 10 [Homo sapiens]
          Length = 1344

 Score =  890 bits (2301), Expect = 0.0
 Identities = 519/1166 (44%), Positives = 703/1166 (60%), Gaps = 86/1166 (7%)

Query: 127  EDVIYDDVPCESPDAHQPGAERNLLYEDAHRAGAPRQAE-DLGWSSSEFESYSEDSGEEA 185
            E+ IYDDVP E+ D+        ++Y+D         +  + GWSSSEFESY E S  E 
Sbjct: 210  EEAIYDDVPRENSDSEPD----EMIYDDVENGDEGGNSSLEYGWSSSEFESYEEQSDSEC 265

Query: 186  KPEVE-------------------------------------VEPAKHRVSFQPKMTQLM 208
            K  +                                      VE  + R   + KM +L+
Sbjct: 266  KNGIPRSFLRSNHKKQLSHDLTRLKEHYEKKMRDLMASTVGVVEIQQLRQKHELKMQKLV 325

Query: 209  KAAKSGTKDGLEKTRMAVMRKVSFLHRKDVLGDS-----EEEDMGLLEVSVSDIKPPAPE 263
            KAAK GTKDGLE+TR AV R  SF+  K ++        EEE    ++V   D K P   
Sbjct: 326  KAAKDGTKDGLERTRAAVKRGRSFIRTKSLIAQDHRSSLEEEQNLFIDV---DCKHPEAI 382

Query: 264  LGPMPEGLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQVV 323
            L PMPEGLS QQVVRR+ILGS+V SE +YV++LKRIL+ Y  PL EMEPK LS RK + V
Sbjct: 383  LTPMPEGLSQQQVVRRYILGSVVDSEKNYVDALKRILEQYEKPLSEMEPKVLSERKLKTV 442

Query: 324  FFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSAMS 383
            F+RVKEIL CHS+FQIAL+SRV+EWDS E IGD+FVASFSKSMVLD YS+YVNNF++A++
Sbjct: 443  FYRVKEILQCHSLFQIALASRVSEWDSVEMIGDVFVASFSKSMVLDAYSEYVNNFSTAVA 502

Query: 384  IIKKACLTKPAFLEFLKRRQVCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPD 443
            ++KK C TKPAFLEFLK+ Q  SPDR TLY LM+KPIQRFPQFILLLQDMLKNT +GHPD
Sbjct: 503  VLKKTCATKPAFLEFLKQEQEASPDRTTLYSLMMKPIQRFPQFILLLQDMLKNTSKGHPD 562

Query: 444  RLSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLCET 503
            RL LQ+ALTELETLAEKLNE+KR ADQ  E++Q+ K++++R  LNKLL+SG R L+  + 
Sbjct: 563  RLPLQMALTELETLAEKLNERKRDADQRCEVKQIAKAINER-YLNKLLSSGSRYLIRSDD 621

Query: 504  LTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKPANHRGQLEISSLVPLGPKYVVKWN 563
            + ETVY DRG+++K+KERRVF+LND+L+CA ++ +P++        S V    +Y++KW+
Sbjct: 622  MIETVYNDRGEIVKTKERRVFMLNDVLMCATVSSRPSH-------DSRVMSSQRYLLKWS 674

Query: 564  TALPQVQVVEVGQDGGTYDKDNVLIQHSGAKKASASGQAQNKVYLGPPRLFQELQDLQKD 623
              L  V  +E G   GT +    L  H     A  +    NKVY+GP +L+Q+LQ+L  D
Sbjct: 675  VPLGHVDAIEYGSSAGTGEHSRHLAVHPPESLAVVANAKPNKVYMGPGQLYQDLQNLLHD 734

Query: 624  LAVVEQITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHSANKCRLRLLLPGKP 683
            L V+ QIT LI  L G YQNLN +VA DW   LQRL+  KE+EI +A+ CR++L LPGK 
Sbjct: 735  LNVIGQITQLIGNLKGNYQNLNQSVAHDWTSGLQRLILKKEDEIRAADCCRIQLQLPGKQ 794

Query: 684  DKSGRPISFMVVFITPNPLSKISWVNRLHLAKIGLREENQPGWLCPDEDKKSKAPFWCPI 743
            DKSGRP  F  VF T  P  K SWVN L +AK+ L EEN  GW C ++D         P+
Sbjct: 795  DKSGRPTFFTAVFNTFTPAIKESWVNSLQMAKLALEEENHMGWFCVEDDGNHIKKEKHPL 854

Query: 744  LACCIPAFSSRALSLQLGALVHSPVNCPLLGFSAV--STSLPQGYLWVGGGQEGAGGQVE 801
            L   +P   ++    ++    ++P   P L   +   S S   G+LW+G       GQ+ 
Sbjct: 855  LVGHMPVMVAKQQEFKIECAAYNPE--PYLNNESQPDSFSTAHGFLWIGSCTHQM-GQIA 911

Query: 802  IFSLNRPSPRTVKSFPLAAPVLCMEYIPELEEEAESRDESPTVADPS--ATVHPTICLGL 859
            I S    +P+ ++ F + + +LCM Y+P +EE+       P    P+  A+  PTIC+G 
Sbjct: 912  IVSFQNSTPKVIECFNVESRILCMLYVP-VEEKRREPGAPPDPETPAVRASDVPTICVGT 970

Query: 860  QDGSILLYSSVDTGTQC-LVSCRSPGLQPVLCLRHSPFHLLAGLQDGTLAAYPRTSGGVL 918
            ++GSI +Y S     +  L    +P    V+ L  +   L AGL +G +A+Y R   G  
Sbjct: 971  EEGSISIYKSSQGSKKVRLQHFFTPEKSTVMSLACTSQSLYAGLVNGAVASYARAPDG-S 1029

Query: 919  WDLESPPVCLTVGPGPVRTLLSLEDAVWASCGPRVTVLEATTLQPQQSFEAHQDEAVSVT 978
            WD E P   + +G  PVR+LL +ED +WA+ G +V ++   T   +   EAHQ+E + ++
Sbjct: 1030 WDSE-PQKVIKLGVLPVRSLLMMEDTLWAASGGQVFIISVETHAVEGQLEAHQEEGMVIS 1088

Query: 979  HMVKAGSGVWMAFSSGTSIRLFHTETLEHLQEINIATRTTFLLPGQKHLCVTSLLICQGL 1038
            HM  +G G+W+AF+SG+++RLFHTETL+HLQ+INIAT    +LPG + L VTSLL+C GL
Sbjct: 1089 HMAVSGVGIWIAFTSGSTLRLFHTETLKHLQDINIATPVHNMLPGHQRLSVTSLLVCHGL 1148

Query: 1039 LWVGTDQGVIVLLPVPRLEGIPKITGKGMVSLNGHCGPVAFLAVATSILAPDILRSDQEE 1098
            L VGT  GV+V LPVPRL+GIPK+TG+GMVS + H  PV F+ +AT++   D  +S    
Sbjct: 1149 LMVGTSLGVLVALPVPRLQGIPKVTGRGMVSYHAHNSPVKFIVLATALHEKDKDKSRDSL 1208

Query: 1099 AEGPR-AEEDKPDGQAHEPMPDSHVGRELTR---KKGILLQYRLRSTAHLPGPLLSMREP 1154
            A GP   +ED+ D      +P    G  L++      I L   L S         S    
Sbjct: 1209 APGPEPQDEDQKDA-----LPSGGAGSSLSQGDPDAAIWLGDSLGSMTQKSDLSSSSGSL 1263

Query: 1155 APADG-AALEHSEEDGSIYEMADDPDIWVRSRPCARDAHRKEICSVAIISGGQGYRNFGS 1213
            + + G ++LEH  ED +IY++  DP   V  R  AR A + +  S  ++ GGQG+R    
Sbjct: 1264 SLSHGSSSLEHRSEDSTIYDLLKDP---VSLRSKARRAKKAKASSALVVCGGQGHRR--- 1317

Query: 1214 ALGSSGRQAPCGETDSTLLIWQVPLM 1239
             +    RQ    E   T+++WQ+PL+
Sbjct: 1318 -VHRKARQPHQEELAPTVMVWQIPLL 1342


>gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17 [Homo
            sapiens]
          Length = 2063

 Score =  162 bits (410), Expect = 2e-39
 Identities = 146/602 (24%), Positives = 269/602 (44%), Gaps = 83/602 (13%)

Query: 260  PAPELGPMPEGLSPQQV-VRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKAL-SA 317
            PA E  P  +  S  QV +R+H+  +++ +E SYVESL+ ++Q Y  PL + E   L   
Sbjct: 1048 PADEPTPASKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDP 1107

Query: 318  RKCQVVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNN 377
                 +F ++ E+L  H  F   +   +  W + +K+G L V SFSK +++++YS Y++N
Sbjct: 1108 SLVDEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDN 1167

Query: 378  FTSAMSIIKKACLTKPAFLEFLKRRQVCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKNT 437
            F +A   ++ A   +PAFL+FL++    + ++  L  LM+KP+QR P++ LL++D+LK+T
Sbjct: 1168 FLNAKDAVRVAKEARPAFLKFLEQSMRENKEKQALSDLMIKPVQRIPRYELLVKDLLKHT 1227

Query: 438  PRGHPDRLSLQLALTELETLAEKLNEQKRLADQVAE----IQQLTKSVSDRSSLNKLLTS 493
            P  HPD   L  A   ++ +AE++N+  R A++       +Q++   +     L   L  
Sbjct: 1228 PEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRR 1287

Query: 494  GQRQLLLCETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKPAN-HRGQLEI---S 549
              RQ ++ E   + + G        K+R +FL  D++VC  +  K  +  R  + +   +
Sbjct: 1288 FLRQEMVIE--VKAIGG-------KKDRSLFLFTDLIVCTTLKRKSGSLRRSSMSLYTAA 1338

Query: 550  SLVPLGPKYVVKWNTALPQVQVVEVGQDGGTYDKDNVLIQHSGAKKASASGQAQNKVYLG 609
            S++    KY + W   L    +++                         + QA N+    
Sbjct: 1339 SVIDTASKYKMLWKLPLEDADIIK------------------------GASQATNR---- 1370

Query: 610  PPRLFQELQDLQKDLAVVEQITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHS 669
               + + +  L +DL  + Q++ L  +L   +Q+L+    +D   A+ R +  K+   ++
Sbjct: 1371 -ENIQKAISRLDEDLTTLGQMSKLSESLGFPHQSLD-DALRDLSAAMHRDLSEKQALCYA 1428

Query: 670  ANKCRLRL-LLPGKPDKSGRPISFMVVFITPNPLSKISWVNRLHLAKIGLREENQPGWLC 728
             +    +L L   +P+ +        +F  P+P +++ +      AK  L         C
Sbjct: 1429 LSFPPTKLELCATRPEGTD-----SYIFEFPHPDARLGFEQAFDEAKRKLASSKS----C 1479

Query: 729  PDEDKKSKAPFWCPILACCIPAFSSRALSLQLGALVHSPVNCPLLGFSAVSTSLPQGYLW 788
             D           P     IP   +R+  +Q      +  +CP           P   +W
Sbjct: 1480 LD-----------PEFLKAIPIMKTRS-GMQFSCAAPTLNSCP----------EPSPEVW 1517

Query: 789  VGGGQEGAGGQVEIFSLNRPSPRTVKSFPLAAPVLCMEYIPELEEEAESRDESPTVADPS 848
            V    +G  GQV + SL             +A +LC+  +P L+     R+  P++  P 
Sbjct: 1518 V-CNSDGYVGQVCLLSLRAEPDVEACIAVCSARILCIGAVPGLQPRCH-REPPPSLRSPP 1575

Query: 849  AT 850
             T
Sbjct: 1576 ET 1577



 Score =  114 bits (285), Expect = 6e-25
 Identities = 112/411 (27%), Positives = 159/411 (38%), Gaps = 100/411 (24%)

Query: 846  DPSATVHPTICLGLQDGSILLYSSVDTGTQCLVSCRSPGLQPVLCLRHSPFHLLAGLQDG 905
            DP A    ++ LG +DG + +Y S D+      S +      V C+ +    +   L +G
Sbjct: 1733 DPEA-YQSSVWLGTEDGCVHVYQSSDSIRDRRNSMKLQHAASVTCILYLNNQVFVSLANG 1791

Query: 906  TLAAYPRTSGGVLWDLES-PPVCLTVGPGPVRTLLSLEDAVWASCGPRVTVLEATTLQPQ 964
             L  Y R +G   WD ++   V L     P+  ++S+   +W  C  RV VL   TLQ +
Sbjct: 1792 ELVVYQREAGH-FWDPQNFKSVTLGTQGSPITKMVSVGGRLWCGCQNRVLVLSPDTLQLE 1850

Query: 965  QSFEAHQDEAVSVTHMVKAGSGVWMAFSSGTSIRLFHTETLEHLQEINIATRTTFLLPG- 1023
              F   QD +  V  MV +  GVW+       + L+H +T E L E+++      +L G 
Sbjct: 1851 HMFYVGQDSSRCVACMVDSSLGVWVTLKGSAHVCLYHPDTFEQLAEVDVTPPVHRMLAGS 1910

Query: 1024 ----QKH----LCVTSLLICQGLLWVGTDQGVIVLLPV-PRLEGIPKI----TGKGMVSL 1070
                ++H    L +T+LL+C+ LLWVGT  GV++ +P  P     P+     TG G    
Sbjct: 1911 DAIIRQHKAACLRITALLVCEELLWVGTSAGVVLTMPTSPGTVSCPRAPLSPTGLG---- 1966

Query: 1071 NGHCGPVAFLAVATSILAPDILRSDQEEAEGPRAEEDKPDG---QAHEPMPDSHVGRELT 1127
             GH G V FLA                           PDG       P P    G E  
Sbjct: 1967 QGHTGHVRFLAAV-----------------------QLPDGFNLLCPTPPPPPDTGPE-- 2001

Query: 1128 RKKGILLQYRLRSTAHLPGPLLSMREPAPADGAALEHSEEDGSIYEMADDPDIWVRSRPC 1187
                     +L S  H   P    R PAPA                           RP 
Sbjct: 2002 ---------KLPSLEHRDSPW--HRGPAPA---------------------------RP- 2022

Query: 1188 ARDAHRKEICSVAIISGGQGYRNFGSALGSSGRQAPCGETDST--LLIWQV 1236
                       + +ISGG GY +F  + G        G  DST  LL+W+V
Sbjct: 2023 ----------KMLVISGGDGYEDFRLSSGGGSSSETVGRDDSTNHLLLWRV 2063


>gi|94557295 mitogen-activated protein kinase 8 interacting protein 3
            isoform 2 [Homo sapiens]
          Length = 1330

 Score =  112 bits (280), Expect = 2e-24
 Identities = 80/261 (30%), Positives = 130/261 (49%), Gaps = 18/261 (6%)

Query: 807  RPSPRTVKSF------PLAAPVLCMEYIPELEEEAESRDESPTVADPS---ATVHPTICL 857
            RP P T   F      P + P    E  PE  + + +R E     DP+   ++  PT+ L
Sbjct: 909  RPGPLTEHVFTDPAPTPSSGPQPGSENGPE-PDSSSTRPEPEPSGDPTGAGSSAAPTMWL 967

Query: 858  GLQDGSILLYSSVDTGTQCLVSCRSPGLQPVLCLRHSPFHLLAGLQDGTLAAYPRTSGGV 917
            G Q+G + ++S+V    +CL S +      VL L H    +L  L DGTLA + R   G 
Sbjct: 968  GAQNGWLYVHSAVANWKKCLHSIKLK--DSVLSLVHVKGRVLVALADGTLAIFHRGEDGQ 1025

Query: 918  LWDLESPPVCLTVGPG-PVRTLLSLEDAVWASCGPRVTVLEATTLQPQQSFEAHQDEAVS 976
             WDL +  +     P   +R +  + D VW     +V V++  T+Q ++SF+AH      
Sbjct: 1026 -WDLSNYHLMDLGHPHHSIRCMAVVYDRVWCGYKNKVHVIQPKTMQIEKSFDAHPRRESQ 1084

Query: 977  VTHMVKAGSGVWMAFSSGTSIRLFHTETLEHLQEINIATRTTFLLP----GQKHLCVTSL 1032
            V  +   G GVW++    +++RL+H  T +HLQ+++I    + +L     G   + +T+L
Sbjct: 1085 VRQLAWIGDGVWVSIRLDSTLRLYHAHTHQHLQDVDIEPYVSKMLGTGKLGFSFVRITAL 1144

Query: 1033 LICQGLLWVGTDQGVIVLLPV 1053
            L+    LWVGT  GV++ +P+
Sbjct: 1145 LVAGSRLWVGTGNGVVISIPL 1165


>gi|94557297 mitogen-activated protein kinase 8 interacting protein 3
            isoform 1 [Homo sapiens]
          Length = 1336

 Score =  112 bits (280), Expect = 2e-24
 Identities = 80/261 (30%), Positives = 130/261 (49%), Gaps = 18/261 (6%)

Query: 807  RPSPRTVKSF------PLAAPVLCMEYIPELEEEAESRDESPTVADPS---ATVHPTICL 857
            RP P T   F      P + P    E  PE  + + +R E     DP+   ++  PT+ L
Sbjct: 915  RPGPLTEHVFTDPAPTPSSGPQPGSENGPE-PDSSSTRPEPEPSGDPTGAGSSAAPTMWL 973

Query: 858  GLQDGSILLYSSVDTGTQCLVSCRSPGLQPVLCLRHSPFHLLAGLQDGTLAAYPRTSGGV 917
            G Q+G + ++S+V    +CL S +      VL L H    +L  L DGTLA + R   G 
Sbjct: 974  GAQNGWLYVHSAVANWKKCLHSIKLK--DSVLSLVHVKGRVLVALADGTLAIFHRGEDGQ 1031

Query: 918  LWDLESPPVCLTVGPG-PVRTLLSLEDAVWASCGPRVTVLEATTLQPQQSFEAHQDEAVS 976
             WDL +  +     P   +R +  + D VW     +V V++  T+Q ++SF+AH      
Sbjct: 1032 -WDLSNYHLMDLGHPHHSIRCMAVVYDRVWCGYKNKVHVIQPKTMQIEKSFDAHPRRESQ 1090

Query: 977  VTHMVKAGSGVWMAFSSGTSIRLFHTETLEHLQEINIATRTTFLLP----GQKHLCVTSL 1032
            V  +   G GVW++    +++RL+H  T +HLQ+++I    + +L     G   + +T+L
Sbjct: 1091 VRQLAWIGDGVWVSIRLDSTLRLYHAHTHQHLQDVDIEPYVSKMLGTGKLGFSFVRITAL 1150

Query: 1033 LICQGLLWVGTDQGVIVLLPV 1053
            L+    LWVGT  GV++ +P+
Sbjct: 1151 LVAGSRLWVGTGNGVVISIPL 1171


>gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens]
          Length = 1227

 Score =  105 bits (261), Expect = 3e-22
 Identities = 79/288 (27%), Positives = 130/288 (45%), Gaps = 36/288 (12%)

Query: 277 VRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKA---LSARKCQVVFFRVKEILHC 333
           +R+ +L  I+ SE +Y+  L+ +L   + PL      +   L++++ + +FF+V E+   
Sbjct: 498 MRKWVLSGILASEETYLSHLEALLLPMK-PLKAAATTSQPVLTSQQIETIFFKVPELYEI 556

Query: 334 HSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSAMSIIKKACLTKP 393
           H  F   L  RV +W   +++GDLF    S+   L VY  +V+N+  AM + +K C    
Sbjct: 557 HKEFYDGLFPRVQQWSHQQRVGDLFQKLASQ---LGVYRAFVDNYGVAMEMAEKCCQANA 613

Query: 394 AFLEFLKRRQVCS-------PDRVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLS 446
            F E  +  +  S         + +L  L+ KP+ R  +  L+L D+LK+TP  HPD   
Sbjct: 614 QFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPL 673

Query: 447 LQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLCETLTE 506
           LQ AL   +     +NE+                ++ R     +     RQLL    + E
Sbjct: 674 LQDALRISQNFLSSINEE----------------ITPRRQSMTVKKGEHRQLLKDSFMVE 717

Query: 507 TVYGDRGQLIKSKERRVFLLNDMLVCANINFKPANHRGQLEISSLVPL 554
            V G R      K R VFL  D+L+C  +  +      Q +    +PL
Sbjct: 718 LVEGAR------KLRHVFLFTDLLLCTKLKKQSGGKTQQYDCKWYIPL 759


>gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens]
          Length = 1271

 Score =  105 bits (261), Expect = 3e-22
 Identities = 79/288 (27%), Positives = 130/288 (45%), Gaps = 36/288 (12%)

Query: 277 VRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKA---LSARKCQVVFFRVKEILHC 333
           +R+ +L  I+ SE +Y+  L+ +L   + PL      +   L++++ + +FF+V E+   
Sbjct: 498 MRKWVLSGILASEETYLSHLEALLLPMK-PLKAAATTSQPVLTSQQIETIFFKVPELYEI 556

Query: 334 HSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSAMSIIKKACLTKP 393
           H  F   L  RV +W   +++GDLF    S+   L VY  +V+N+  AM + +K C    
Sbjct: 557 HKEFYDGLFPRVQQWSHQQRVGDLFQKLASQ---LGVYRAFVDNYGVAMEMAEKCCQANA 613

Query: 394 AFLEFLKRRQVCS-------PDRVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLS 446
            F E  +  +  S         + +L  L+ KP+ R  +  L+L D+LK+TP  HPD   
Sbjct: 614 QFAEISENLRARSNKDAKDPTTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPL 673

Query: 447 LQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLCETLTE 506
           LQ AL   +     +NE+                ++ R     +     RQLL    + E
Sbjct: 674 LQDALRISQNFLSSINEE----------------ITPRRQSMTVKKGEHRQLLKDSFMVE 717

Query: 507 TVYGDRGQLIKSKERRVFLLNDMLVCANINFKPANHRGQLEISSLVPL 554
            V G R      K R VFL  D+L+C  +  +      Q +    +PL
Sbjct: 718 LVEGAR------KLRHVFLFTDLLLCTKLKKQSGGKTQQYDCKWYIPL 759


>gi|21735572 epithelial cell transforming sequence 2 oncogene
           protein [Homo sapiens]
          Length = 883

 Score =  103 bits (256), Expect = 1e-21
 Identities = 79/271 (29%), Positives = 134/271 (49%), Gaps = 16/271 (5%)

Query: 274 QQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKA---LSARKCQVVFFRVKEI 330
           +Q  R  +   + Q+E +YV  L  I+Q ++ PL E   +    L+  + + +F  + +I
Sbjct: 418 KQSARWQVAKELYQTESNYVNILATIIQLFQVPLEEEGQRGGPILAPEEIKTIFGSIPDI 477

Query: 331 LHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSAMSIIKKACL 390
              H+  +  L   +  WD ++ IGD+F+  +SK +V   Y  +VN F  +   I K   
Sbjct: 478 FDVHTKIKDDLEDLIVNWDESKSIGDIFL-KYSKDLV-KTYPPFVNFFEMSKETIIKCEK 535

Query: 391 TKPAFLEFLKRRQVCSPD--RVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLSLQ 448
            KP F  FLK  Q   P+  R +L  L+++P+QR P   LLL D+ K+T   +PD+ +L+
Sbjct: 536 QKPRFHAFLKINQA-KPECGRQSLVELLIRPVQRLPSVALLLNDLKKHTADENPDKSTLE 594

Query: 449 LALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLCETLTETV 508
            A+  L+ +   +NE KR  +   +I  +   V    +   LL+S +  +   ET++   
Sbjct: 595 KAIGSLKEVMTHINEDKRKTEAQKQIFDVVYEVDGCPA--NLLSSHRSLVQRVETISLGE 652

Query: 509 YG-DRGQLIKSKERRVFLLNDMLVCANINFK 538
           +  DRG+ +      +FL ND L  A    K
Sbjct: 653 HPCDRGEQV-----TLFLFNDCLEIARKRHK 678


>gi|194578923 sperm associated antigen 9 isoform 1 [Homo sapiens]
          Length = 1321

 Score =  103 bits (256), Expect = 1e-21
 Identities = 65/224 (29%), Positives = 117/224 (52%), Gaps = 11/224 (4%)

Query: 845  ADPSATVHPTICLGLQDGSILLYSSVDTGTQCLVSCRSPGLQPVLCLRHSPFHLLAGLQD 904
            A   +++ PT+ LG Q+G + ++SSV    +CL S +      +L + H    +L  L D
Sbjct: 962  AQKMSSLLPTMWLGAQNGCLYVHSSVAQWRKCLHSIKLK--DSILSIVHVKGIVLVALAD 1019

Query: 905  GTLAAYPRTSGGVLWDLESPPVCLTVGPG-PVRTLLSLEDAVWASCGPRVTVLEATTLQP 963
            GTLA + R   G  WDL +  +     P   +R +  + D VW     ++ V++   ++ 
Sbjct: 1020 GTLAIFHRGVDGQ-WDLSNYHLLDLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAMKI 1078

Query: 964  QQSFEAHQDEAVSVTHMVKAGSGVWMAFSSGTSIRLFHTETLEHLQEINIATRTTFLLP- 1022
            ++SF+AH  +   V  +   G GVW++    +++RL+H  T +HLQ+++I    + +L  
Sbjct: 1079 EKSFDAHPRKESQVRQLAWVGDGVWVSIRLDSTLRLYHAHTYQHLQDVDIEPYVSKMLGT 1138

Query: 1023 ---GQKHLCVTSLLICQGLLWVGTDQGVIVLLPVP---RLEGIP 1060
               G   + +T+L++    LWVGT  GVI+ +P+    +  G+P
Sbjct: 1139 GKLGFSFVRITALMVSCNRLWVGTGNGVIISIPLTETNKTSGVP 1182


>gi|27436920 sperm associated antigen 9 isoform 3 [Homo sapiens]
          Length = 1307

 Score =  103 bits (256), Expect = 1e-21
 Identities = 65/224 (29%), Positives = 117/224 (52%), Gaps = 11/224 (4%)

Query: 845  ADPSATVHPTICLGLQDGSILLYSSVDTGTQCLVSCRSPGLQPVLCLRHSPFHLLAGLQD 904
            A   +++ PT+ LG Q+G + ++SSV    +CL S +      +L + H    +L  L D
Sbjct: 948  AQKMSSLLPTMWLGAQNGCLYVHSSVAQWRKCLHSIKLK--DSILSIVHVKGIVLVALAD 1005

Query: 905  GTLAAYPRTSGGVLWDLESPPVCLTVGPG-PVRTLLSLEDAVWASCGPRVTVLEATTLQP 963
            GTLA + R   G  WDL +  +     P   +R +  + D VW     ++ V++   ++ 
Sbjct: 1006 GTLAIFHRGVDGQ-WDLSNYHLLDLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAMKI 1064

Query: 964  QQSFEAHQDEAVSVTHMVKAGSGVWMAFSSGTSIRLFHTETLEHLQEINIATRTTFLLP- 1022
            ++SF+AH  +   V  +   G GVW++    +++RL+H  T +HLQ+++I    + +L  
Sbjct: 1065 EKSFDAHPRKESQVRQLAWVGDGVWVSIRLDSTLRLYHAHTYQHLQDVDIEPYVSKMLGT 1124

Query: 1023 ---GQKHLCVTSLLICQGLLWVGTDQGVIVLLPVP---RLEGIP 1060
               G   + +T+L++    LWVGT  GVI+ +P+    +  G+P
Sbjct: 1125 GKLGFSFVRITALMVSCNRLWVGTGNGVIISIPLTETNKTSGVP 1168


>gi|229094128 active breakpoint cluster region-related  protein
           isoform c [Homo sapiens]
          Length = 813

 Score = 93.6 bits (231), Expect = 1e-18
 Identities = 81/303 (26%), Positives = 130/303 (42%), Gaps = 42/303 (13%)

Query: 268 PEGLSPQQV------VRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKA---LSAR 318
           PEGL+P         +R+ +L   + SE  Y+  L+ +L   + PL      +   L+ +
Sbjct: 30  PEGLAPGVEAGKGLEMRKLVLSGFLASEEIYINQLEALLLPMK-PLKATATTSQPVLTIQ 88

Query: 319 KCQVVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNF 378
           + + +F+++++I   H  F   L  +V +WDS   +G LF    S+   L VY  +V+N+
Sbjct: 89  QIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQ---LGVYKAFVDNY 145

Query: 379 TSAMSIIKKACLTKPAFLEFLKRRQVCSPD-------RVTLYGLMVKPIQRFPQFILLLQ 431
             A+   +K   +   F +  +  +V  P         VT+  L+ KPI R  +  L+L 
Sbjct: 146 KVALETAEKCSQSNNQFQKISEELKVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLH 205

Query: 432 DMLKNTPRGHPDRLSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLL 491
           D+LK+TP  HPD   LQ AL   +     +NE                 +  R +     
Sbjct: 206 DLLKHTPVDHPDYPLLQDALRISQNFLSSINED----------------IDPRRTAVTTP 249

Query: 492 TSGQRQLLLCETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKPANHRGQLEISSL 551
               RQL+    L E     R      K R VFL  D+L+CA +    A    Q +    
Sbjct: 250 KGETRQLVKDGFLVEVSESSR------KLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWY 303

Query: 552 VPL 554
           +PL
Sbjct: 304 IPL 306


>gi|38679957 active breakpoint cluster region-related  protein
           isoform a [Homo sapiens]
          Length = 859

 Score = 93.6 bits (231), Expect = 1e-18
 Identities = 81/303 (26%), Positives = 130/303 (42%), Gaps = 42/303 (13%)

Query: 268 PEGLSPQQV------VRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKA---LSAR 318
           PEGL+P         +R+ +L   + SE  Y+  L+ +L   + PL      +   L+ +
Sbjct: 76  PEGLAPGVEAGKGLEMRKLVLSGFLASEEIYINQLEALLLPMK-PLKATATTSQPVLTIQ 134

Query: 319 KCQVVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNF 378
           + + +F+++++I   H  F   L  +V +WDS   +G LF    S+   L VY  +V+N+
Sbjct: 135 QIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQ---LGVYKAFVDNY 191

Query: 379 TSAMSIIKKACLTKPAFLEFLKRRQVCSPD-------RVTLYGLMVKPIQRFPQFILLLQ 431
             A+   +K   +   F +  +  +V  P         VT+  L+ KPI R  +  L+L 
Sbjct: 192 KVALETAEKCSQSNNQFQKISEELKVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLH 251

Query: 432 DMLKNTPRGHPDRLSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLL 491
           D+LK+TP  HPD   LQ AL   +     +NE                 +  R +     
Sbjct: 252 DLLKHTPVDHPDYPLLQDALRISQNFLSSINED----------------IDPRRTAVTTP 295

Query: 492 TSGQRQLLLCETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKPANHRGQLEISSL 551
               RQL+    L E     R      K R VFL  D+L+CA +    A    Q +    
Sbjct: 296 KGETRQLVKDGFLVEVSESSR------KLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWY 349

Query: 552 VPL 554
           +PL
Sbjct: 350 IPL 352


>gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac
           exchange factor 1 [Homo sapiens]
          Length = 1659

 Score = 90.9 bits (224), Expect = 7e-18
 Identities = 89/330 (26%), Positives = 155/330 (46%), Gaps = 29/330 (8%)

Query: 261 APELGPMPEGLSPQQV----VRRHILGSIVQSEGSYVESLKRI----LQDYRNPLMEMEP 312
           AP  GP P   + +      +R  +L  I+ +E  YV +L+ +    L   R  + +   
Sbjct: 29  APSSGPGPCAAARESERQLRLRLCVLNEILGTERDYVGTLRFLQSAFLHRIRQNVADSVE 88

Query: 313 KALSARKCQVVFFRVKEILHCHSMFQIALSSRV-AEWDSTEKIGDLFVASFSKSMVLDVY 371
           K L+    +V+F  +++IL  H  F  AL   +  E  S  ++G++F+    K  V   Y
Sbjct: 89  KGLTEENVKVLFSNIEDILEVHKDFLAALEYCLHPEPQSQHELGNVFLKFKDKFCV---Y 145

Query: 372 SDYVNNFTSAMSIIKKACLTK-PAFLEFLKRRQVCSPDRVT---LYGLMVKPIQRFPQFI 427
            +Y +N   A+ ++ +  L K P    FL    +    + T   L G ++ PIQR  ++ 
Sbjct: 146 EEYCSNHEKALRLLVE--LNKIPTVRAFLLSCMLLGGRKTTDIPLEGYLLSPIQRICKYP 203

Query: 428 LLLQDMLKNTPRGHPDRLSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSL 487
           LLL+++ K TP  HPD  ++Q AL  ++T+   +NE KR  +++  ++QL   +      
Sbjct: 204 LLLKELAKRTPGKHPDHPAVQSALQAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGS 263

Query: 488 NKLLTSGQRQLLLCETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKPANHRGQLE 547
           N  LT    QLLL  TL +   G+       +ER  FL +++LV      +    +   +
Sbjct: 264 N--LTDICTQLLLQGTLLKISAGN------IQERAFFLFDNLLVYCKRKSRVTGSKKSTK 315

Query: 548 ISSLVPLGPKYVVKW--NTALPQVQVVEVG 575
            +  +  G  Y+ +   NT + +V+ VE G
Sbjct: 316 RTKSIN-GSLYIFRGRINTEVMEVENVEDG 344


>gi|38679954 active breakpoint cluster region-related  protein
           isoform b [Homo sapiens]
          Length = 822

 Score = 90.9 bits (224), Expect = 7e-18
 Identities = 76/288 (26%), Positives = 124/288 (43%), Gaps = 36/288 (12%)

Query: 277 VRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKA---LSARKCQVVFFRVKEILHC 333
           +R+ +L   + SE  Y+  L+ +L   + PL      +   L+ ++ + +F+++++I   
Sbjct: 54  MRKLVLSGFLASEEIYINQLEALLLPMK-PLKATATTSQPVLTIQQIETIFYKIQDIYEI 112

Query: 334 HSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSAMSIIKKACLTKP 393
           H  F   L  +V +WDS   +G LF    S+   L VY  +V+N+  A+   +K   +  
Sbjct: 113 HKEFYDNLCPKVQQWDSQVTMGHLFQKLASQ---LGVYKAFVDNYKVALETAEKCSQSNN 169

Query: 394 AFLEFLKRRQVCSPD-------RVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLS 446
            F +  +  +V  P         VT+  L+ KPI R  +  L+L D+LK+TP  HPD   
Sbjct: 170 QFQKISEELKVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPDYPL 229

Query: 447 LQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLCETLTE 506
           LQ AL   +     +NE                 +  R +         RQL+    L E
Sbjct: 230 LQDALRISQNFLSSINED----------------IDPRRTAVTTPKGETRQLVKDGFLVE 273

Query: 507 TVYGDRGQLIKSKERRVFLLNDMLVCANINFKPANHRGQLEISSLVPL 554
                R      K R VFL  D+L+CA +    A    Q +    +PL
Sbjct: 274 VSESSR------KLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWYIPL 315


>gi|134133248 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]
          Length = 725

 Score = 86.7 bits (213), Expect = 1e-16
 Identities = 76/303 (25%), Positives = 145/303 (47%), Gaps = 40/303 (13%)

Query: 243 EEEDMGLLEVSVSDIKPP-APELGPMPEGLSPQQVVRRHILGSIVQSEGSYVESLKRILQ 301
           EE D  + E   S+  P  A +   + +   PQ+++  HI   ++ +E +YV+ L  + Q
Sbjct: 124 EEADSDVGEEPDSENTPQKADKDAGLAQHSGPQKLL--HIAQELLHTEETYVKRLHLLDQ 181

Query: 302 DYRNPLME--MEPKALSARKCQVVFFRVKEILHCHSMFQIA-LSSRVAE-WDSTEKIGDL 357
            +   L +  + P+ +       +F  +  I   H  F +  L +R+ E WD+  ++GD+
Sbjct: 182 VFCTRLTDAGIPPEVIMG-----IFSNISSIHRFHGQFLLPELKTRITEEWDTNPRLGDI 236

Query: 358 F--VASFSKSMVLDVYSDYVNNFTSAMSIIKKACLTKPAFLEF---LKRRQVCSPDRVTL 412
              +A F K     +Y +YV NF  A+ ++       P F +    +++++VC    +TL
Sbjct: 237 LQKLAPFLK-----MYGEYVKNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEVCG--NLTL 289

Query: 413 YGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLSLQLALTELETLAEKLNEQKRLADQVA 472
              M++P+QR P++ LLL+D LK  P+  PDR   + +L  + T A   N   R  +++ 
Sbjct: 290 QHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRKDAERSLELISTAANHSNAAIRKVEKMH 349

Query: 473 EIQQLTKSVSDRSSL----NKLLTSGQRQLLLCETLTETVYGDRGQLIKSKERRVFLLND 528
           ++ ++ + +     +    N+L+  GQ Q L  +  T             ++R +FL N 
Sbjct: 350 KLLEVYEQLGGEEDIVNPANELIKEGQIQKLSAKNGT------------PQDRHLFLFNS 397

Query: 529 MLV 531
           M++
Sbjct: 398 MIL 400


>gi|134133265 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]
          Length = 725

 Score = 86.7 bits (213), Expect = 1e-16
 Identities = 76/303 (25%), Positives = 145/303 (47%), Gaps = 40/303 (13%)

Query: 243 EEEDMGLLEVSVSDIKPP-APELGPMPEGLSPQQVVRRHILGSIVQSEGSYVESLKRILQ 301
           EE D  + E   S+  P  A +   + +   PQ+++  HI   ++ +E +YV+ L  + Q
Sbjct: 124 EEADSDVGEEPDSENTPQKADKDAGLAQHSGPQKLL--HIAQELLHTEETYVKRLHLLDQ 181

Query: 302 DYRNPLME--MEPKALSARKCQVVFFRVKEILHCHSMFQIA-LSSRVAE-WDSTEKIGDL 357
            +   L +  + P+ +       +F  +  I   H  F +  L +R+ E WD+  ++GD+
Sbjct: 182 VFCTRLTDAGIPPEVIMG-----IFSNISSIHRFHGQFLLPELKTRITEEWDTNPRLGDI 236

Query: 358 F--VASFSKSMVLDVYSDYVNNFTSAMSIIKKACLTKPAFLEF---LKRRQVCSPDRVTL 412
              +A F K     +Y +YV NF  A+ ++       P F +    +++++VC    +TL
Sbjct: 237 LQKLAPFLK-----MYGEYVKNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEVCG--NLTL 289

Query: 413 YGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLSLQLALTELETLAEKLNEQKRLADQVA 472
              M++P+QR P++ LLL+D LK  P+  PDR   + +L  + T A   N   R  +++ 
Sbjct: 290 QHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRKDAERSLELISTAANHSNAAIRKVEKMH 349

Query: 473 EIQQLTKSVSDRSSL----NKLLTSGQRQLLLCETLTETVYGDRGQLIKSKERRVFLLND 528
           ++ ++ + +     +    N+L+  GQ Q L  +  T             ++R +FL N 
Sbjct: 350 KLLEVYEQLGGEEDIVNPANELIKEGQIQKLSAKNGT------------PQDRHLFLFNS 397

Query: 529 MLV 531
           M++
Sbjct: 398 MIL 400


>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
          Length = 1721

 Score = 85.5 bits (210), Expect = 3e-16
 Identities = 74/289 (25%), Positives = 139/289 (48%), Gaps = 22/289 (7%)

Query: 271  LSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQVVFFRVKEI 330
            L+P +  R+  +  ++ +E +YV  L+ + + ++ PLME E   L+ ++  ++F   KE+
Sbjct: 1231 LTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQKPLMESE--LLTEKEVAMIFVNWKEL 1288

Query: 331  LHCHSMFQIALSSRVAEWDSTEK-----IGDLFVASFSKSMVLDVYSDYVNNFTSAMSII 385
            + C+     AL  RV +  S EK     IGD+  A       +  Y  + +   +  ++I
Sbjct: 1289 IMCNIKLLKAL--RVRKKMSGEKMPVKMIGDILSAQLPH---MQPYIRFCSRQLNGAALI 1343

Query: 386  KKACLTKPAFLEFLKRRQVCSPDR-VTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDR 444
            ++     P F EF+KR  +    + + L   ++KP+QR  ++ L+++++L+NTP  HPD 
Sbjct: 1344 QQKTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTPENHPDH 1403

Query: 445  LSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLCETL 504
              L+ AL + E L  ++NE  R  +    ++ +   V       +L+ +      +   L
Sbjct: 1404 SHLKHALEKAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLSEQLVFNS-----VTNCL 1458

Query: 505  TETVYGDRGQLIKSKERRV---FLLNDMLVCANINFKPANHRGQLEISS 550
                +   G+L K+K  +    FL ND L+   I  KP    G  ++ S
Sbjct: 1459 GPRKFLHSGKLYKAKSNKELYGFLFNDFLLLTQIT-KPLGSSGTDKVFS 1506


>gi|118150678 epithelial cell transforming sequence 2 oncogene-like
           [Homo sapiens]
          Length = 904

 Score = 84.3 bits (207), Expect = 6e-16
 Identities = 69/266 (25%), Positives = 127/266 (47%), Gaps = 15/266 (5%)

Query: 278 RRHILGSIVQSEGSYVESLKRILQDYRNPL---MEMEPKALSARKCQVVFFRVKEILHCH 334
           R  ++  ++QSE  YV+ L+ +   Y  PL   +      LSA   Q++F  + +IL  +
Sbjct: 567 RARVVRELLQSERKYVQILEIVRDVYVAPLKAALSSNRAILSAANIQIIFCDILQILSLN 626

Query: 335 SMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSAMSIIKKACLTKPA 394
             F   L  R+ EW     +G++ V  F     L+ Y+++ NN+   +  I+K     PA
Sbjct: 627 RQFLDNLRDRLQEWGPAHCVGEI-VTKFGSQ--LNTYTNFFNNYPVILKTIEKCREMIPA 683

Query: 395 FLEFLKRR-QVCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLSLQLALTE 453
           F  FLKR  +      ++L  L++ P +RF +++ LL  +  +TP  H DR  L  A+ +
Sbjct: 684 FRTFLKRHDKTIVTKMLSLPELLLYPSRRFEEYLNLLYAVRLHTPAEHVDRGDLTTAIDQ 743

Query: 454 LETLAEKLNEQKR---LADQVAEIQQLTKSVSDRSSLNKLLTSGQ--RQLLLCETLTETV 508
           ++     +++ K+   + D +++IQ++       S +N+ L   Q   QL  C+   E +
Sbjct: 744 IKKYKGYIDQMKQNITMKDHLSDIQRIIWGCPTLSEVNRYLIRVQDVAQLHCCD---EEI 800

Query: 509 YGDRGQLIKSKERRVFLLNDMLVCAN 534
                      +  +FL ND L+ ++
Sbjct: 801 SFSLRLYEHIHDLSLFLFNDALLVSS 826


>gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens]
          Length = 766

 Score = 84.0 bits (206), Expect = 8e-16
 Identities = 75/304 (24%), Positives = 141/304 (46%), Gaps = 44/304 (14%)

Query: 281 ILGSIVQSEGSYVESLKRILQDYRNPLMEMEPK-ALSARKCQVVFFRVKEILHCHSMFQI 339
           I   ++ +E +YV  L  + Q +   L+E   + +  A     +F  +  I   HS F +
Sbjct: 210 IANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSINAFHSKFLL 269

Query: 340 A-LSSRVAEWDSTEKIGDLF--VASFSKSMVLDVYSDYVNNFTSAMSIIKKACLTKPAF- 395
             L  R+ EW++T +IGD+   +A F K     +Y +YV  F +AM ++K      P F 
Sbjct: 270 PELEKRMQEWETTPRIGDILQKLAPFLK-----MYGEYVKGFDNAMELVKNMTERIPQFK 324

Query: 396 --LEFLKRRQVCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLSLQLALTE 453
             +E ++++++C    +TL   M++P+QR P++ +LL+D L+  P    D    + +L  
Sbjct: 325 SVVEEIQKQKICGS--LTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEI 382

Query: 454 LETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSL----NKLLTSGQRQLLLCETLTETVY 509
           + T A   N   R  + + ++ ++ + + +   +    N+L+  GQ   L     +    
Sbjct: 383 ISTAASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTS---- 438

Query: 510 GDRGQLIKSKERRVFLLNDMLVCANINFKPANHRGQLEISSLVPLGPKYVVKWNTALPQV 569
                   ++ER +FL N+ML+     F            SLV  G K+ V+    +  +
Sbjct: 439 --------AQERYLFLFNNMLLYCVPKF------------SLV--GSKFTVRTRVGIDGM 476

Query: 570 QVVE 573
           ++VE
Sbjct: 477 KIVE 480


>gi|164565408 common-site lymphoma/leukemia guanine nucleotide
           exchange factor [Homo sapiens]
          Length = 1386

 Score = 84.0 bits (206), Expect = 8e-16
 Identities = 69/285 (24%), Positives = 135/285 (47%), Gaps = 23/285 (8%)

Query: 267 MPEGLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQVVFFR 326
           +P    P ++ R  +   IV++E +YV  L+ I++DY  PL++     LS  +   +F  
Sbjct: 94  IPGSARPSRLER--VAREIVETERAYVRDLRSIVEDYLGPLLDGGVLGLSVEQVGTLFAN 151

Query: 327 VKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSAMSIIK 386
           +++I      F   L   +    S   I + FV    +S   D+Y+ Y  N+ S++++++
Sbjct: 152 IEDIYE----FSSELLEDLENSSSAGGIAECFV---QRSEDFDIYTLYCMNYPSSLALLR 204

Query: 387 KACLTKPAFLEFLKRRQVCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKNTPR--GHPDR 444
           +  L+ PA L +L+ RQ      + L   ++KP+QR  ++ LLLQ++ K+     G   R
Sbjct: 205 ELSLSPPAAL-WLQERQAQLRHSLPLQSFLLKPVQRILKYHLLLQELGKHWAEGPGTGGR 263

Query: 445 LSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLCETL 504
             ++ A+  +  +A  +N+ KR  +  A +Q++ + +           +G       E +
Sbjct: 264 EMVEEAIVSMTAVAWYINDMKRKQEHAARLQEVQRRLGG--------WTGPELSAFGELV 315

Query: 505 TETVY---GDRGQLIKSKERRVFLLNDMLVCANINFKPANHRGQL 546
            E  +   G  G  ++  ER +FL + ML+ A        ++G +
Sbjct: 316 LEGAFRGGGGGGPRLRGGERLLFLFSRMLLVAKRRGLEYTYKGHI 360


>gi|24797153 faciogenital dysplasia protein [Homo sapiens]
          Length = 961

 Score = 82.8 bits (203), Expect = 2e-15
 Identities = 125/484 (25%), Positives = 189/484 (39%), Gaps = 54/484 (11%)

Query: 13  GDQLVPGVPGPSSEAEDDPGEAFEFDDSDDEEDTSAALGVPSLAPERDTDPPLIHLDSIP 72
           G  L P   GP      DPG   E       +  S     P   P+    P  + +  +P
Sbjct: 120 GQSLEPHPEGPQ-RLRSDPGPPTE----TPSQRPSPLKRAPGPKPQVPPKPSYLQMPRMP 174

Query: 73  VTDPDPAAAPPGTGVPA--WVSNGDA--ADAAFSGARHSSWKRKSSRR-----IDRFT-- 121
               +P   PP   +PA   V+ G A  A+A+ S A  SS   K  R       DR    
Sbjct: 175 -PPLEPIPPPPSRPLPADPRVAKGLAPRAEASPSSAAVSSLIEKFEREPVIVASDRPVPG 233

Query: 122 -FPALEEDVIYDDVPCESPDAHQPGAERNLLYEDAHRAGAPRQAEDLGWSSSEFESYSED 180
             P   E V+      + P    P  E +        A  PR  E +    S  +S S  
Sbjct: 234 PSPGPPEPVMLPQPTSQPPVPQLPEGEASRCL--FLLAPGPRDGEKVPNRDSGIDSISSP 291

Query: 181 SGEEAKPEVEVE-PAKHRVSFQPKMTQLMKAAKSGTKDGLEKTRMAVMRKVSFLHRKDVL 239
           S  E    V  + P  H +   P     +  A +      +  R       S L  +D  
Sbjct: 292 SNSEETCFVSDDGPPSHSLCPGPPALASVPVALA------DPHRPGSQEVDSDLEEEDDE 345

Query: 240 GDSEEEDMGLLEVSVSDIKPPAPELGPMPEGLSPQQVVRRHILGSIVQSEGSYVESLKRI 299
            + EE+D         +I  P  E     E    Q+V   HI   ++Q+E +YV  L  +
Sbjct: 346 EEEEEKDR--------EIPVPLMERQESVELTVQQKVF--HIANELLQTEKAYVSRLHLL 395

Query: 300 LQDYRNPLMEMEPKALSARKCQVV---FFRVKEILHCHSMFQIA-LSSRVAEWDSTEKIG 355
            Q +   L+E E +  S+    VV   F  +  I   H  F +  L  R+ EWD   +IG
Sbjct: 396 DQVFCARLLE-EARNRSSFPADVVHGIFSNICSIYCFHQQFLLPELEKRMEEWDRYPRIG 454

Query: 356 DLF--VASFSKSMVLDVYSDYVNNFTSAMSIIKKACLTKPAF---LEFLKRRQVCSPDRV 410
           D+   +A F K     +Y +YV NF  A+ ++         F   +  +++ + C    +
Sbjct: 455 DILQKLAPFLK-----MYGEYVKNFDRAVELVNTWTERSTQFKVIIHEVQKEEACG--NL 507

Query: 411 TLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLSLQLALTELETLAEKLNEQKRLADQ 470
           TL   M++P+QR P++ LLL+D L   P G PD    Q +L  + T AE  N   R  ++
Sbjct: 508 TLQHHMLEPVQRIPRYELLLKDYLLKLPHGSPDSKDAQKSLELIATAAEHSNAAIRKMER 567

Query: 471 VAEI 474
           + ++
Sbjct: 568 MHKL 571


>gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens]
          Length = 655

 Score = 78.6 bits (192), Expect = 4e-14
 Identities = 67/233 (28%), Positives = 108/233 (46%), Gaps = 15/233 (6%)

Query: 272 SPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEM--EPKALSARKCQVVFFRVKE 329
           S  Q   + I+  ++++E +YV  L  + Q +   L++     KA      +V+F  +  
Sbjct: 97  SGTQEPEKKIVQELLETEQAYVARLHLLDQVFFQELLKTARSSKAFPEDVVRVIFSNISS 156

Query: 330 ILHCHSMFQIA-LSSRVAEWDSTEKIGDLF--VASFSKSMVLDVYSDYVNNFTSAMSIIK 386
           I   HS F +  L  R+ +W +  +IGD+   +A F K     +YS+YV NF  A  ++ 
Sbjct: 157 IYQFHSQFFLPELQRRLDDWTANPRIGDVIQKLAPFLK-----MYSEYVKNFERAAELLA 211

Query: 387 KACLTKPAFLEFLKRRQVCSPD-RVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRL 445
                 P F E L R Q       +TL   M++P+QR P++ LLL++ ++  P   PD+ 
Sbjct: 212 TWTDKSPLFQEVLTRIQSSEASGSLTLQHHMLEPVQRIPRYELLLKEYIQKLPAQAPDQA 271

Query: 446 SLQLALTELETLAEKLN----EQKRLADQVAEIQQLTKSVSDRSSLNKLLTSG 494
             Q AL  + + A+  N    E +RL D     Q+L          N LL  G
Sbjct: 272 DAQKALDMIFSAAQHSNAAITEMERLQDLWEVYQRLGLEDDIVDPSNTLLREG 324


>gi|45439359 triple functional domain (PTPRF interacting) [Homo
            sapiens]
          Length = 3097

 Score = 78.6 bits (192), Expect = 4e-14
 Identities = 96/381 (25%), Positives = 163/381 (42%), Gaps = 51/381 (13%)

Query: 170  SSSEFESYSEDSGEEA------------------KPEVEVEPAKHRVSFQPKMTQLMKAA 211
            SSS  +S  E+ GEE                   +P+ + + A  R+  +P  ++   AA
Sbjct: 1848 SSSGMQSCGEEEGEEGADAVPLPPPMAIQQHSLLQPDSQDDKASSRLLVRPTSSETPSAA 1907

Query: 212  KSGTK-DGLEKTRMAVMRKVSFLHRKDVLGDSEEEDMGLLEVSVSDIKPPAPELGPMPEG 270
            +  +  + L K++MA+  + S L      GDS        + S+     P  E   M E 
Sbjct: 1908 ELVSAIEELVKSKMALEDRPSSLLVDQ--GDSSSPSFNPSDNSLLSSSSPIDE---MEER 1962

Query: 271  LSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQVVFFRVKEI 330
             S     R ++L  +V++E  YV  L  +++ Y   + E         K ++VF  + +I
Sbjct: 1963 KSSSLKRRHYVLQELVETERDYVRDLGYVVEGYMALMKEDGVPDDMKGKDKIVFGNIHQI 2022

Query: 331  LHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSAMSIIKKACL 390
               H  F +    +  E    EK+G LFV    +   L +Y  Y  N   +  I+ +   
Sbjct: 2023 YDWHRDFFLGELEKCLE--DPEKLGSLFVKHERR---LHMYIAYCQNKPKSEHIVSEYID 2077

Query: 391  TKPAFLEFLKRRQVCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLSLQLA 450
            T   F E LK+R      R+ L  L++KP+QR  ++ LLL+D LK + +   D   L+ A
Sbjct: 2078 T---FFEDLKQRL---GHRLQLTDLLIKPVQRIMKYQLLLKDFLKYSKKASLDTSELERA 2131

Query: 451  LTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLCETLTETVYG 510
            +  +  +  + N+       V  +Q             K++  G  +LLL +T   T   
Sbjct: 2132 VEVMCIVPRRCNDMM----NVGRLQGFD---------GKIVAQG--KLLLQDTFLVTDQ- 2175

Query: 511  DRGQLIKSKERRVFLLNDMLV 531
            D G L + +ERR+FL   +++
Sbjct: 2176 DAGLLPRCRERRIFLFEQIVI 2196



 Score = 37.7 bits (86), Expect = 0.069
 Identities = 45/207 (21%), Positives = 86/207 (41%), Gaps = 30/207 (14%)

Query: 278  RRHILGSIVQSEGSYVESLKRILQDY----RNPLMEMEPKALSARKCQVVFFRVKEILHC 333
            +  I+  ++Q+E +YV  L+  +  Y     + + E+ P  ++  K  ++F  ++EI   
Sbjct: 1293 KEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVN--KELIIFGNMQEIYEF 1350

Query: 334  HSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSAMSIIKKACLTKP 393
            H+   I L          E +G  FV    K     +Y  Y  N   +  +I +   +  
Sbjct: 1351 HN--NIFLKELEKYEQLPEDVGHCFVTWADK---FQMYVTYCKNKPDSTQLILEHAGSY- 1404

Query: 394  AFLEFLKRRQVCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGH------------ 441
             F E  +R  + +    ++   ++KP+QR  ++ LLL+++L     G             
Sbjct: 1405 -FDEIQQRHGLAN----SISSYLIKPVQRITKYQLLLKELLTCCEEGKGEIKDGLEVMLS 1459

Query: 442  -PDRLSLQLALTELETLAEKLNEQKRL 467
             P R +  + L+ LE   E +  Q  L
Sbjct: 1460 VPKRANDAMHLSMLEGFDENIESQGEL 1486


>gi|154240686 FYVE, RhoGEF and PH domain containing 6 [Homo sapiens]
          Length = 1430

 Score = 78.6 bits (192), Expect = 4e-14
 Identities = 80/338 (23%), Positives = 146/338 (43%), Gaps = 26/338 (7%)

Query: 152  YEDAHRAGAPRQAEDLGWSSSEFESYSEDSGEEAKPEV-EVEPAKHRVSFQPKMTQLMKA 210
            YE+     A R+ ++L W +S        S E+A   V EVE        Q ++    + 
Sbjct: 760  YENLPFIMAIRKTQELEWQNSS-------SMEDADANVYEVEEPYEAPDGQLQLGPRHQH 812

Query: 211  AKSGTKDGLEKTRMAVMRKVSFLHRKDVLGDSEEEDMGLLEVSVSDIKPPAPELGPMPEG 270
            + SG     E+  + +    S    ++++  S+E+D+     S S    P P      E 
Sbjct: 813  SSSGASQE-EQNDLGLGDLPS--DEEEIINSSDEDDVS----SESSKGEPDPLEDKQDED 865

Query: 271  LSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLM----EMEPKALSARKCQVVFFR 326
               +  V  HI   I+ SE  +V+ LK +  D+R+ +     ++    +  R    + + 
Sbjct: 866  NGMKSKVH-HIAKEIMSSEKVFVDVLKLLHIDFRDAVAHASRQLGKPVIEDRILNQILYY 924

Query: 327  VKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSAMSIIK 386
            + ++   +      L  R+  W   ++I D+FV    K   L +YS Y+  F   ++++ 
Sbjct: 925  LPQLYELNRDLLKELEERMLHWTEQQRIADIFV---KKGPYLKMYSTYIKEFDKNIALLD 981

Query: 387  KACLTKPAFLEFLKRRQVCSPD--RVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDR 444
            + C   P F   ++  ++ SP    + L   ++KP+QR PQ+ LLL D LKN      D 
Sbjct: 982  EQCKKNPGFAAVVREFEM-SPRCANLALKHYLLKPVQRIPQYRLLLTDYLKNLIEDAGDY 1040

Query: 445  LSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVS 482
               Q AL  +  +A   N+  +  D   ++ Q+  S++
Sbjct: 1041 RDTQDALAVVIEVANHANDTMKQGDNFQKLMQIQYSLN 1078


>gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a
           [Homo sapiens]
          Length = 690

 Score = 76.3 bits (186), Expect = 2e-13
 Identities = 59/263 (22%), Positives = 115/263 (43%), Gaps = 9/263 (3%)

Query: 269 EGLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQVVFFRVK 328
           E  S +  +R +++  I+ +E  Y++ L+ I + Y     +      S  + + +F  ++
Sbjct: 276 EAQSSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRK-RADMFSEEQLRTIFGNIE 334

Query: 329 EILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSAMSIIKKA 388
           +I  C   F  AL  R         + +L            +YS+Y NN  +A   + + 
Sbjct: 335 DIYRCQKAFVKALEQRFNR--ERPHLSELGACFLEHQADFQIYSEYCNNHPNACVELSRL 392

Query: 389 CLTKPAFLEFLKRRQVCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLSLQ 448
                    F   R +     ++L G ++ P+Q+  ++ L L ++LK T   H D   ++
Sbjct: 393 TKLSKYVYFFEACRLLQKMIDISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRDFKDVE 452

Query: 449 LALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLCETLTETV 508
            AL  ++ +A+ +NE+KR  + + +I Q   S+ D    + L+ S   +L+    LT   
Sbjct: 453 AALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDLLVRSS--ELIYSGELTRVT 510

Query: 509 YGDRGQLIKSKERRVFLLNDMLV 531
                   KS++R  FL +  L+
Sbjct: 511 QPQ----AKSQQRMFFLFDHQLI 529


>gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b
           [Homo sapiens]
          Length = 670

 Score = 76.3 bits (186), Expect = 2e-13
 Identities = 59/263 (22%), Positives = 115/263 (43%), Gaps = 9/263 (3%)

Query: 269 EGLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQVVFFRVK 328
           E  S +  +R +++  I+ +E  Y++ L+ I + Y     +      S  + + +F  ++
Sbjct: 276 EAQSSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRK-RADMFSEEQLRTIFGNIE 334

Query: 329 EILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSAMSIIKKA 388
           +I  C   F  AL  R         + +L            +YS+Y NN  +A   + + 
Sbjct: 335 DIYRCQKAFVKALEQRFNR--ERPHLSELGACFLEHQADFQIYSEYCNNHPNACVELSRL 392

Query: 389 CLTKPAFLEFLKRRQVCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLSLQ 448
                    F   R +     ++L G ++ P+Q+  ++ L L ++LK T   H D   ++
Sbjct: 393 TKLSKYVYFFEACRLLQKMIDISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRDFKDVE 452

Query: 449 LALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLCETLTETV 508
            AL  ++ +A+ +NE+KR  + + +I Q   S+ D    + L+ S   +L+    LT   
Sbjct: 453 AALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDLLVRSS--ELIYSGELTRVT 510

Query: 509 YGDRGQLIKSKERRVFLLNDMLV 531
                   KS++R  FL +  L+
Sbjct: 511 QPQ----AKSQQRMFFLFDHQLI 529


>gi|224586880 Ras protein-specific guanine nucleotide-releasing
           factor 1 isoform 3 [Homo sapiens]
          Length = 1257

 Score = 74.3 bits (181), Expect = 7e-13
 Identities = 63/251 (25%), Positives = 124/251 (49%), Gaps = 37/251 (14%)

Query: 278 RRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQV-------VFFRVKEI 330
           R  ++ S++++E  YV+ L  ++ ++  PL      A S++K  +       +F   + I
Sbjct: 241 RNQVVFSMLEAEAEYVQQLHILVNNFLRPLR----MAASSKKPPITHDDVSSIFLNSETI 296

Query: 331 LHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSAMSIIKKACL 390
           +  H +F   L +R++ W  T  + DLF        +L++Y ++V N   ++ I+   C 
Sbjct: 297 MFLHQIFYQGLKARISSWP-TLVLADLFDILLP---MLNIYQEFVRNHQYSLQILAH-CK 351

Query: 391 TKPAFLEFLKRRQVCSPD--RVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLSLQ 448
               F + LK  +   PD    TL   +  P+ + P++IL L ++L +TP  H +R SL 
Sbjct: 352 QNRDFDKLLKHYEA-KPDCEERTLETFLTYPMFQIPRYILTLHELLAHTPHEHVERNSLD 410

Query: 449 LALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLCETLTET- 507
            A ++LE L+  ++      D+V+E + + K++    ++ +++  G      CE L +T 
Sbjct: 411 YAKSKLEELSRIMH------DEVSETENIRKNL----AIERMIIEG------CEILLDTS 454

Query: 508 -VYGDRGQLIK 517
             +  +G LI+
Sbjct: 455 QTFVRQGSLIQ 465


>gi|24797099 Ras protein-specific guanine nucleotide-releasing
           factor 1 isoform 1 [Homo sapiens]
          Length = 1273

 Score = 74.3 bits (181), Expect = 7e-13
 Identities = 63/251 (25%), Positives = 124/251 (49%), Gaps = 37/251 (14%)

Query: 278 RRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQV-------VFFRVKEI 330
           R  ++ S++++E  YV+ L  ++ ++  PL      A S++K  +       +F   + I
Sbjct: 241 RNQVVFSMLEAEAEYVQQLHILVNNFLRPLR----MAASSKKPPITHDDVSSIFLNSETI 296

Query: 331 LHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSAMSIIKKACL 390
           +  H +F   L +R++ W  T  + DLF        +L++Y ++V N   ++ I+   C 
Sbjct: 297 MFLHQIFYQGLKARISSWP-TLVLADLFDILLP---MLNIYQEFVRNHQYSLQILAH-CK 351

Query: 391 TKPAFLEFLKRRQVCSPD--RVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLSLQ 448
               F + LK  +   PD    TL   +  P+ + P++IL L ++L +TP  H +R SL 
Sbjct: 352 QNRDFDKLLKHYEA-KPDCEERTLETFLTYPMFQIPRYILTLHELLAHTPHEHVERNSLD 410

Query: 449 LALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLCETLTET- 507
            A ++LE L+  ++      D+V+E + + K++    ++ +++  G      CE L +T 
Sbjct: 411 YAKSKLEELSRIMH------DEVSETENIRKNL----AIERMIIEG------CEILLDTS 454

Query: 508 -VYGDRGQLIK 517
             +  +G LI+
Sbjct: 455 QTFVRQGSLIQ 465


>gi|71274148 pleckstrin homology domain containing, family G (with
           RhoGef domain) member 1 [Homo sapiens]
          Length = 1385

 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 56/269 (20%), Positives = 124/269 (46%), Gaps = 12/269 (4%)

Query: 272 SPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQVVFFRVKEIL 331
           SP+ +    ++  I+++E +YV+ LK I++DY + + +     L   +   +F  +++I 
Sbjct: 108 SPKLLYVDRVVQEILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTEERSALFGNIQDIY 167

Query: 332 HCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSAMSIIKKACLT 391
           H +S  ++       E D    I + FV   SKS    +Y+ Y  N+  +++++ + C+ 
Sbjct: 168 HFNS--ELLQDLENCENDPV-AIAECFV---SKSEEFHIYTQYCTNYPRSVAVLTE-CMR 220

Query: 392 KPAFLEFLKRRQVCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLSLQLAL 451
                +F + RQ      + L   ++KP+QR  ++ LLL ++  +  +       +  A+
Sbjct: 221 NKILAKFFRERQETLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAI 280

Query: 452 TELETLAEKLNEQKRLADQVAEIQQLTKSVS-----DRSSLNKLLTSGQRQLLLCETLTE 506
             ++ +A  +N+ KR  +    +Q++   ++     D +S  +L+  G  ++   +    
Sbjct: 281 DTMQRVAWHINDMKRKHEHAVRLQEIQSLLTNWKGPDLTSYGELVLEGTFRIQRAKNERT 340

Query: 507 TVYGDRGQLIKSKERRVFLLNDMLVCANI 535
               D+  LI  K    F     ++C N+
Sbjct: 341 LFLFDKLLLITKKRDDTFTYKAHILCGNL 369


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 54,138,223
Number of Sequences: 37866
Number of extensions: 2795736
Number of successful extensions: 10933
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 70
Number of HSP's successfully gapped in prelim test: 120
Number of HSP's that attempted gapping in prelim test: 10501
Number of HSP's gapped (non-prelim): 466
length of query: 1240
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1126
effective length of database: 13,930,794
effective search space: 15686074044
effective search space used: 15686074044
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.