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Search of human proteins with 74027267
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|74027267 ubiquitin-specific protease 21 [Homo sapiens]
(565 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|62243586 ubiquitin-specific protease 21 [Homo sapiens] 1159 0.0
gi|74027267 ubiquitin-specific protease 21 [Homo sapiens] 1159 0.0
gi|28565285 ubiquitin specific peptidase 2 isoform b [Homo sapiens] 339 5e-93
gi|188528692 ubiquitin specific peptidase 2 isoform a [Homo sapi... 339 5e-93
gi|190684694 ubiquitin specific peptidase 8 [Homo sapiens] 212 8e-55
gi|190684692 ubiquitin specific peptidase 8 [Homo sapiens] 212 8e-55
gi|190684690 ubiquitin specific peptidase 8 [Homo sapiens] 212 8e-55
gi|55770886 ubiquitin thiolesterase 3 [Homo sapiens] 174 1e-43
gi|45267835 ubiquitin specific protease 50 [Homo sapiens] 140 4e-33
gi|150010639 ubiquitin thiolesterase 22 [Homo sapiens] 133 5e-31
gi|122114651 ubiquitin specific peptidase 36 [Homo sapiens] 130 4e-30
gi|14149627 ubiquitin specific peptidase 15 [Homo sapiens] 128 2e-29
gi|40795665 ubiquitin specific protease 4 isoform a [Homo sapiens] 127 2e-29
gi|40795667 ubiquitin specific protease 4 isoform b [Homo sapiens] 127 2e-29
gi|223005906 X-linked ubiquitin thioesterase 27 [Homo sapiens] 126 5e-29
gi|57529246 ubiquitin thioesterase 19 [Homo sapiens] 124 2e-28
gi|79750944 ubiquitin specific peptidase 42 [Homo sapiens] 124 3e-28
gi|41152235 ubiquitin specific protease 51 [Homo sapiens] 120 4e-27
gi|42516561 ubiquitin specific protease 33 isoform 3 [Homo sapiens] 118 2e-26
gi|239742282 PREDICTED: hypothetical protein XP_002342474 [Homo ... 118 2e-26
gi|22550104 ubiquitin specific protease 32 [Homo sapiens] 118 2e-26
gi|109638751 ubiquitin specific protease 6 [Homo sapiens] 117 2e-26
gi|169217654 PREDICTED: similar to deubiquitinating enzyme DUB1 ... 117 3e-26
gi|197116355 ubiquitin specific peptidase 46 isoform 2 [Homo sap... 117 4e-26
gi|31377709 ubiquitin specific peptidase 46 isoform 1 [Homo sapi... 117 4e-26
gi|239742287 PREDICTED: hypothetical protein XP_002342475 [Homo ... 117 4e-26
gi|239758075 PREDICTED: similar to deubiquitinating enzyme DUB1 ... 116 6e-26
gi|239742297 PREDICTED: hypothetical protein XP_002342480 [Homo ... 116 6e-26
gi|113415490 PREDICTED: similar to deubiquitinating enzyme 1 [Ho... 115 1e-25
gi|113415488 PREDICTED: similar to deubiquitinating enzyme 1 [Ho... 115 1e-25
>gi|62243586 ubiquitin-specific protease 21 [Homo sapiens]
Length = 565
Score = 1159 bits (2998), Expect = 0.0
Identities = 565/565 (100%), Positives = 565/565 (100%)
Query: 1 MPQASEHRLGRTREPPVNIQPRVGSKLPFAPRARSKERRNPASGPNPMLRPLPPRPGLPD 60
MPQASEHRLGRTREPPVNIQPRVGSKLPFAPRARSKERRNPASGPNPMLRPLPPRPGLPD
Sbjct: 1 MPQASEHRLGRTREPPVNIQPRVGSKLPFAPRARSKERRNPASGPNPMLRPLPPRPGLPD 60
Query: 61 ERLKKLELGRGRTSGPRPRGPLRADHGVPLPGSPPPTVALPLPSRTNLARSKSVSSGDLR 120
ERLKKLELGRGRTSGPRPRGPLRADHGVPLPGSPPPTVALPLPSRTNLARSKSVSSGDLR
Sbjct: 61 ERLKKLELGRGRTSGPRPRGPLRADHGVPLPGSPPPTVALPLPSRTNLARSKSVSSGDLR 120
Query: 121 PMGIALGGHRGTGELGAALSRLALRPEPPTLRRSTSLRRLGGFPGPPTLFSIRTEPPASH 180
PMGIALGGHRGTGELGAALSRLALRPEPPTLRRSTSLRRLGGFPGPPTLFSIRTEPPASH
Sbjct: 121 PMGIALGGHRGTGELGAALSRLALRPEPPTLRRSTSLRRLGGFPGPPTLFSIRTEPPASH 180
Query: 181 GSFHMISARSSEPFYSDDKMAHHTLLLGSGHVGLRNLGNTCFLNAVLQCLSSTRPLRDFC 240
GSFHMISARSSEPFYSDDKMAHHTLLLGSGHVGLRNLGNTCFLNAVLQCLSSTRPLRDFC
Sbjct: 181 GSFHMISARSSEPFYSDDKMAHHTLLLGSGHVGLRNLGNTCFLNAVLQCLSSTRPLRDFC 240
Query: 241 LRRDFRQEVPGGGRAQELTEAFADVIGALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQ 300
LRRDFRQEVPGGGRAQELTEAFADVIGALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQ
Sbjct: 241 LRRDFRQEVPGGGRAQELTEAFADVIGALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQ 300
Query: 301 DAQEFLKLLMERLHLEINRRGRRAPPILANGPVPSPPRRGGALLEEPELSDDDRANLMWK 360
DAQEFLKLLMERLHLEINRRGRRAPPILANGPVPSPPRRGGALLEEPELSDDDRANLMWK
Sbjct: 301 DAQEFLKLLMERLHLEINRRGRRAPPILANGPVPSPPRRGGALLEEPELSDDDRANLMWK 360
Query: 361 RYLEREDSKIVDLFVGQLKSCLKCQACGYRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCF 420
RYLEREDSKIVDLFVGQLKSCLKCQACGYRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCF
Sbjct: 361 RYLEREDSKIVDLFVGQLKSCLKCQACGYRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCF 420
Query: 421 NLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSASRGSIKKSSVGV 480
NLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSASRGSIKKSSVGV
Sbjct: 421 NLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSASRGSIKKSSVGV 480
Query: 481 DFPLQRLSLGDFASDKAGSPVYQLYALCNHSGSVHYGHYTALCRCQTGWHVYNDSRVSPV 540
DFPLQRLSLGDFASDKAGSPVYQLYALCNHSGSVHYGHYTALCRCQTGWHVYNDSRVSPV
Sbjct: 481 DFPLQRLSLGDFASDKAGSPVYQLYALCNHSGSVHYGHYTALCRCQTGWHVYNDSRVSPV 540
Query: 541 SENQVASSEGYVLFYQLMQEPPRCL 565
SENQVASSEGYVLFYQLMQEPPRCL
Sbjct: 541 SENQVASSEGYVLFYQLMQEPPRCL 565
>gi|74027267 ubiquitin-specific protease 21 [Homo sapiens]
Length = 565
Score = 1159 bits (2998), Expect = 0.0
Identities = 565/565 (100%), Positives = 565/565 (100%)
Query: 1 MPQASEHRLGRTREPPVNIQPRVGSKLPFAPRARSKERRNPASGPNPMLRPLPPRPGLPD 60
MPQASEHRLGRTREPPVNIQPRVGSKLPFAPRARSKERRNPASGPNPMLRPLPPRPGLPD
Sbjct: 1 MPQASEHRLGRTREPPVNIQPRVGSKLPFAPRARSKERRNPASGPNPMLRPLPPRPGLPD 60
Query: 61 ERLKKLELGRGRTSGPRPRGPLRADHGVPLPGSPPPTVALPLPSRTNLARSKSVSSGDLR 120
ERLKKLELGRGRTSGPRPRGPLRADHGVPLPGSPPPTVALPLPSRTNLARSKSVSSGDLR
Sbjct: 61 ERLKKLELGRGRTSGPRPRGPLRADHGVPLPGSPPPTVALPLPSRTNLARSKSVSSGDLR 120
Query: 121 PMGIALGGHRGTGELGAALSRLALRPEPPTLRRSTSLRRLGGFPGPPTLFSIRTEPPASH 180
PMGIALGGHRGTGELGAALSRLALRPEPPTLRRSTSLRRLGGFPGPPTLFSIRTEPPASH
Sbjct: 121 PMGIALGGHRGTGELGAALSRLALRPEPPTLRRSTSLRRLGGFPGPPTLFSIRTEPPASH 180
Query: 181 GSFHMISARSSEPFYSDDKMAHHTLLLGSGHVGLRNLGNTCFLNAVLQCLSSTRPLRDFC 240
GSFHMISARSSEPFYSDDKMAHHTLLLGSGHVGLRNLGNTCFLNAVLQCLSSTRPLRDFC
Sbjct: 181 GSFHMISARSSEPFYSDDKMAHHTLLLGSGHVGLRNLGNTCFLNAVLQCLSSTRPLRDFC 240
Query: 241 LRRDFRQEVPGGGRAQELTEAFADVIGALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQ 300
LRRDFRQEVPGGGRAQELTEAFADVIGALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQ
Sbjct: 241 LRRDFRQEVPGGGRAQELTEAFADVIGALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQ 300
Query: 301 DAQEFLKLLMERLHLEINRRGRRAPPILANGPVPSPPRRGGALLEEPELSDDDRANLMWK 360
DAQEFLKLLMERLHLEINRRGRRAPPILANGPVPSPPRRGGALLEEPELSDDDRANLMWK
Sbjct: 301 DAQEFLKLLMERLHLEINRRGRRAPPILANGPVPSPPRRGGALLEEPELSDDDRANLMWK 360
Query: 361 RYLEREDSKIVDLFVGQLKSCLKCQACGYRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCF 420
RYLEREDSKIVDLFVGQLKSCLKCQACGYRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCF
Sbjct: 361 RYLEREDSKIVDLFVGQLKSCLKCQACGYRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCF 420
Query: 421 NLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSASRGSIKKSSVGV 480
NLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSASRGSIKKSSVGV
Sbjct: 421 NLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSASRGSIKKSSVGV 480
Query: 481 DFPLQRLSLGDFASDKAGSPVYQLYALCNHSGSVHYGHYTALCRCQTGWHVYNDSRVSPV 540
DFPLQRLSLGDFASDKAGSPVYQLYALCNHSGSVHYGHYTALCRCQTGWHVYNDSRVSPV
Sbjct: 481 DFPLQRLSLGDFASDKAGSPVYQLYALCNHSGSVHYGHYTALCRCQTGWHVYNDSRVSPV 540
Query: 541 SENQVASSEGYVLFYQLMQEPPRCL 565
SENQVASSEGYVLFYQLMQEPPRCL
Sbjct: 541 SENQVASSEGYVLFYQLMQEPPRCL 565
>gi|28565285 ubiquitin specific peptidase 2 isoform b [Homo sapiens]
Length = 396
Score = 339 bits (869), Expect = 5e-93
Identities = 177/357 (49%), Positives = 233/357 (65%), Gaps = 20/357 (5%)
Query: 210 GHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRAQE-LTEAFADVIGA 268
G GLRNLGNTCF+N++LQCLS+TR LRD+CL+R + +++ G A L E FA +I
Sbjct: 56 GLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHGSNAHTALVEEFAKLIQT 115
Query: 269 LWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPPIL 328
+W + V+P+ F+ Q+Y P F GY+QQDAQEFL+ L++ LH E+NR
Sbjct: 116 IWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNR--------- 166
Query: 329 ANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQACG 388
V P+ L+ L DD++ MW++YLEREDS+I DLFVGQLKS L C CG
Sbjct: 167 ----VTLRPKSNPENLDH--LPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCG 220
Query: 389 YRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTK 448
Y ST F+ F DLSLPI K+G+ +V+L DC LFTKE+ L+ + P C RCR + R K
Sbjct: 221 YCSTVFDPFWDLSLPIAKRGYP--EVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIK 278
Query: 449 KLTVQRFPRILVLHLNRFSASRGSIKKSSVGVDFPLQRLSLGDFASDKAGSPVYQLYALC 508
K ++QRFP+ILVLHL RFS SR K + V+FPL+ L L +FAS+ VY LYA+
Sbjct: 279 KFSIQRFPKILVLHLKRFSESRIRTSKLTTFVNFPLRDLDLREFASENTNHAVYNLYAVS 338
Query: 509 NHSGSVHYGHYTALCRCQ-TG-WHVYNDSRVSPVSENQVASSEGYVLFYQLMQEPPR 563
NHSG+ GHYTA CR TG WH +NDS V+P+S +QV +S+ Y+LFY+L P R
Sbjct: 339 NHSGTTMGGHYTAYCRSPGTGEWHTFNDSSVTPMSSSQVRTSDAYLLFYELASPPSR 395
>gi|188528692 ubiquitin specific peptidase 2 isoform a [Homo
sapiens]
Length = 605
Score = 339 bits (869), Expect = 5e-93
Identities = 177/357 (49%), Positives = 233/357 (65%), Gaps = 20/357 (5%)
Query: 210 GHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRAQE-LTEAFADVIGA 268
G GLRNLGNTCF+N++LQCLS+TR LRD+CL+R + +++ G A L E FA +I
Sbjct: 265 GLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHGSNAHTALVEEFAKLIQT 324
Query: 269 LWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPPIL 328
+W + V+P+ F+ Q+Y P F GY+QQDAQEFL+ L++ LH E+NR
Sbjct: 325 IWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNR--------- 375
Query: 329 ANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQACG 388
V P+ L+ L DD++ MW++YLEREDS+I DLFVGQLKS L C CG
Sbjct: 376 ----VTLRPKSNPENLDH--LPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCG 429
Query: 389 YRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTK 448
Y ST F+ F DLSLPI K+G+ +V+L DC LFTKE+ L+ + P C RCR + R K
Sbjct: 430 YCSTVFDPFWDLSLPIAKRGYP--EVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIK 487
Query: 449 KLTVQRFPRILVLHLNRFSASRGSIKKSSVGVDFPLQRLSLGDFASDKAGSPVYQLYALC 508
K ++QRFP+ILVLHL RFS SR K + V+FPL+ L L +FAS+ VY LYA+
Sbjct: 488 KFSIQRFPKILVLHLKRFSESRIRTSKLTTFVNFPLRDLDLREFASENTNHAVYNLYAVS 547
Query: 509 NHSGSVHYGHYTALCRCQ-TG-WHVYNDSRVSPVSENQVASSEGYVLFYQLMQEPPR 563
NHSG+ GHYTA CR TG WH +NDS V+P+S +QV +S+ Y+LFY+L P R
Sbjct: 548 NHSGTTMGGHYTAYCRSPGTGEWHTFNDSSVTPMSSSQVRTSDAYLLFYELASPPSR 604
>gi|190684694 ubiquitin specific peptidase 8 [Homo sapiens]
Length = 1118
Score = 212 bits (539), Expect = 8e-55
Identities = 125/354 (35%), Positives = 181/354 (51%), Gaps = 26/354 (7%)
Query: 208 GSGHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGG---GRAQELTEAFAD 264
G GLRNLGNTC++N++LQCL + L D+ R ++ ++ G E+ E F
Sbjct: 773 GPALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGI 832
Query: 265 VIGALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRA 324
++ ALW ++P F+ K F+GYSQQD+QE L LM+ LH ++N+ R
Sbjct: 833 IMKALW-TGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNRK 891
Query: 325 PPILANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKC 384
N L D A W+++ + +S IV LF GQ KS ++C
Sbjct: 892 RYKEENND---------------HLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQC 936
Query: 385 QACGYRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKT 444
C +S TFE F LSLP+ K +L+DC LF+KEE+L N C CR +
Sbjct: 937 LTCHKKSRTFEAFMYLSLPLASTS----KCTLQDCLRLFSKEEKLTDNNRFYCSHCRARR 992
Query: 445 RSTKKLTVQRFPRILVLHLNRFSASRGSIKKSSVGVDFPLQRLSLGDFA-SDKAGSPVYQ 503
S KK+ + + P +L++HL RFS +K VDFPL+ L L + K Y
Sbjct: 993 DSLKKIEIWKLPPVLLVHLKRFSYDGRWKQKLQTSVDFPLENLDLSQYVIGPKNNLKKYN 1052
Query: 504 LYALCNHSGSVHYGHYTALCR--CQTGWHVYNDSRVSPVSENQVASSEGYVLFY 555
L+++ NH G + GHYTA C+ + W ++D VS +S + V SS Y+LFY
Sbjct: 1053 LFSVSNHYGGLDGGHYTAYCKNAARQRWFKFDDHEVSDISVSSVKSSAAYILFY 1106
>gi|190684692 ubiquitin specific peptidase 8 [Homo sapiens]
Length = 1118
Score = 212 bits (539), Expect = 8e-55
Identities = 125/354 (35%), Positives = 181/354 (51%), Gaps = 26/354 (7%)
Query: 208 GSGHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGG---GRAQELTEAFAD 264
G GLRNLGNTC++N++LQCL + L D+ R ++ ++ G E+ E F
Sbjct: 773 GPALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGI 832
Query: 265 VIGALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRA 324
++ ALW ++P F+ K F+GYSQQD+QE L LM+ LH ++N+ R
Sbjct: 833 IMKALW-TGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNRK 891
Query: 325 PPILANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKC 384
N L D A W+++ + +S IV LF GQ KS ++C
Sbjct: 892 RYKEENND---------------HLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQC 936
Query: 385 QACGYRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKT 444
C +S TFE F LSLP+ K +L+DC LF+KEE+L N C CR +
Sbjct: 937 LTCHKKSRTFEAFMYLSLPLASTS----KCTLQDCLRLFSKEEKLTDNNRFYCSHCRARR 992
Query: 445 RSTKKLTVQRFPRILVLHLNRFSASRGSIKKSSVGVDFPLQRLSLGDFA-SDKAGSPVYQ 503
S KK+ + + P +L++HL RFS +K VDFPL+ L L + K Y
Sbjct: 993 DSLKKIEIWKLPPVLLVHLKRFSYDGRWKQKLQTSVDFPLENLDLSQYVIGPKNNLKKYN 1052
Query: 504 LYALCNHSGSVHYGHYTALCR--CQTGWHVYNDSRVSPVSENQVASSEGYVLFY 555
L+++ NH G + GHYTA C+ + W ++D VS +S + V SS Y+LFY
Sbjct: 1053 LFSVSNHYGGLDGGHYTAYCKNAARQRWFKFDDHEVSDISVSSVKSSAAYILFY 1106
>gi|190684690 ubiquitin specific peptidase 8 [Homo sapiens]
Length = 1118
Score = 212 bits (539), Expect = 8e-55
Identities = 125/354 (35%), Positives = 181/354 (51%), Gaps = 26/354 (7%)
Query: 208 GSGHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGG---GRAQELTEAFAD 264
G GLRNLGNTC++N++LQCL + L D+ R ++ ++ G E+ E F
Sbjct: 773 GPALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGI 832
Query: 265 VIGALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRA 324
++ ALW ++P F+ K F+GYSQQD+QE L LM+ LH ++N+ R
Sbjct: 833 IMKALW-TGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNRK 891
Query: 325 PPILANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKC 384
N L D A W+++ + +S IV LF GQ KS ++C
Sbjct: 892 RYKEENND---------------HLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQC 936
Query: 385 QACGYRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKT 444
C +S TFE F LSLP+ K +L+DC LF+KEE+L N C CR +
Sbjct: 937 LTCHKKSRTFEAFMYLSLPLASTS----KCTLQDCLRLFSKEEKLTDNNRFYCSHCRARR 992
Query: 445 RSTKKLTVQRFPRILVLHLNRFSASRGSIKKSSVGVDFPLQRLSLGDFA-SDKAGSPVYQ 503
S KK+ + + P +L++HL RFS +K VDFPL+ L L + K Y
Sbjct: 993 DSLKKIEIWKLPPVLLVHLKRFSYDGRWKQKLQTSVDFPLENLDLSQYVIGPKNNLKKYN 1052
Query: 504 LYALCNHSGSVHYGHYTALCR--CQTGWHVYNDSRVSPVSENQVASSEGYVLFY 555
L+++ NH G + GHYTA C+ + W ++D VS +S + V SS Y+LFY
Sbjct: 1053 LFSVSNHYGGLDGGHYTAYCKNAARQRWFKFDDHEVSDISVSSVKSSAAYILFY 1106
>gi|55770886 ubiquitin thiolesterase 3 [Homo sapiens]
Length = 520
Score = 174 bits (442), Expect = 1e-43
Identities = 127/373 (34%), Positives = 175/373 (46%), Gaps = 54/373 (14%)
Query: 213 GLRNLGNTCFLNAVLQCLSSTRPLRDFCL-----------------RRDFRQEVPGGGRA 255
GLRNLGNTCF+NA+LQ LS+ + FC RR + G
Sbjct: 160 GLRNLGNTCFMNAILQSLSN---IEQFCCYFKELPAVELRNGKTAGRRTYHTRSQGDNNV 216
Query: 256 QELTEAFADVIGALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHL 315
L E F + ALW S A +P V K +P+F GY QQDA EF++ L++ LHL
Sbjct: 217 S-LVEEFRKTLCALWQ-GSQTAFSPESLFYVVWKIMPNFRGYQQQDAHEFMRYLLDHLHL 274
Query: 316 EINRRGRRAPPILANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFV 375
E+ NG R L E LS ++ + + + +F
Sbjct: 275 ELQGG--------FNGV-----SRSAILQENSTLSASNKC------CINGASTVVTAIFG 315
Query: 376 GQLKSCLKCQACGYRSTTFEVFCDLSLPIPK-------KGFAGGKV-SLRDCFNLFTKEE 427
G L++ + C CG S F+ F DLSL IP K G V SLRDC FT E
Sbjct: 316 GILQNEVNCLICGTESRKFDPFLDLSLDIPSQFRSKRSKNQENGPVCSLRDCLRSFTDLE 375
Query: 428 ELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSASRGSIKKSSVGVDFPLQRL 487
EL+ +C +C++K +STKK +Q+ P++L LHL RF + K V+FPL+ L
Sbjct: 376 ELDETELYMCHKCKKKQKSTKKFWIQKLPKVLCLHLKRFHWTAYLRNKVDTYVEFPLRGL 435
Query: 488 SLGDFASDKAGSP----VYQLYALCNHSGS-VHYGHYTALCRCQTGWHVYNDSRVSPVSE 542
+ + + S +Y L A+ H GS V GHYTA + W +NDS V+ E
Sbjct: 436 DMKCYLLEPENSGPESCLYDLAAVVVHHGSGVGSGHYTAYATHEGRWFHFNDSTVTLTDE 495
Query: 543 NQVASSEGYVLFY 555
V ++ Y+LFY
Sbjct: 496 ETVVKAKAYILFY 508
>gi|45267835 ubiquitin specific protease 50 [Homo sapiens]
Length = 339
Score = 140 bits (352), Expect = 4e-33
Identities = 104/324 (32%), Positives = 147/324 (45%), Gaps = 41/324 (12%)
Query: 210 GHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDF---RQEVPGGGRAQELTEAFADVI 266
G GL NLGNTC +NA+ QCL S PL ++ L + Q+ E+ AFA ++
Sbjct: 42 GVTGLWNLGNTCCVNAISQCLCSILPLVEYFLTGKYITALQKFLLPSDCSEVATAFAYLM 101
Query: 267 GALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRR--GRRA 324
+W DS + V+P F + P+F+ QQDAQEFL ++ LH + + RR
Sbjct: 102 TDMWLGDS-DCVSPEIFWSALGNLYPAFTKKMQQDAQEFLICVLNELHEALKKYHYSRR- 159
Query: 325 PPILANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKS---C 381
E R W + E S I LF QL C
Sbjct: 160 --------------------RSYEKGSTQRCCRKW---ITTETSIITQLFEEQLNYSIVC 196
Query: 382 LKCQACGYRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCR 441
LKC+ C Y++ F VF SLPIP K + SLRDC F +++ L N C C
Sbjct: 197 LKCEKCTYKNEVFTVF---SLPIPSKY----ECSLRDCLQCFFQQDALTWNNEIHCSFCE 249
Query: 442 QKTRSTKKLTVQRFPRILVLHLNRFSASRGSIKKSSVGVDFPLQRLSLGDF-ASDKAGSP 500
K + + ++ + P+I++ HL RF + +K + +PL L L + S P
Sbjct: 250 TKQETAVRASISKAPKIIIFHLKRFDIQGTTKRKLRTDIHYPLTNLDLTPYICSIFRKYP 309
Query: 501 VYQLYALCNHSGSVHYGHYTALCR 524
Y L A+ NH G + GHYTA C+
Sbjct: 310 KYNLCAVVNHFGDLDGGHYTAFCK 333
>gi|150010639 ubiquitin thiolesterase 22 [Homo sapiens]
Length = 525
Score = 133 bits (334), Expect = 5e-31
Identities = 106/381 (27%), Positives = 156/381 (40%), Gaps = 78/381 (20%)
Query: 213 GLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEV--PGGGRAQELTEAFADVIGALW 270
GL NLGNTCF+N ++Q L+ T LRDF L R E+ P E++ F +
Sbjct: 177 GLINLGNTCFMNCIVQALTHTPLLRDFFLSDRHRCEMQSPSSCLVCEMSSLFQEFYSGHR 236
Query: 271 HPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPPILAN 330
P P + + + +GY QQDA EFL ++ LH N
Sbjct: 237 SPHI-----PYKLLHLVWTHARHLAGYEQQDAHEFLIAALDVLHRHCKGDD--------N 283
Query: 331 GPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQACGYR 390
G + P ++++ +F G L+S + CQ C
Sbjct: 284 GKKANNPNHCNCIIDQ--------------------------IFTGGLQSDVTCQVCHGV 317
Query: 391 STTFEVFCDLSLPIPK-------------------KGFAGGKVSLRDCFNLFTKEEELES 431
STT + F D+SL +P + G +L DC FT+ E L S
Sbjct: 318 STTIDPFWDISLDLPGSSTPFWPLSPGSEGNVVNGESHVSGTTTLTDCLRRFTRPEHLGS 377
Query: 432 ENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSASRGSIKKSSVGVDFPLQRLSLGD 491
C C STK+LT+++ P + HL RF S +K + V FPL+ L +
Sbjct: 378 SAKIKCSGCHSYQESTKQLTMKKLPIVACFHLKRFEHSAKLRRKITTYVSFPLE-LDMTP 436
Query: 492 FASDKAGSPV----------------YQLYALCNHSGSVHYGHYTALCR-CQTGWHVYND 534
F + S + Y L+A+ NH G++ GHYT+ R + W +D
Sbjct: 437 FMASSKESRMNGQYQQPTDSLNNDNKYSLFAVVNHQGTLESGHYTSFIRQHKDQWFKCDD 496
Query: 535 SRVSPVSENQVASSEGYVLFY 555
+ ++ S V SEGY+LFY
Sbjct: 497 AIITKASIKDVLDSEGYLLFY 517
>gi|122114651 ubiquitin specific peptidase 36 [Homo sapiens]
Length = 1123
Score = 130 bits (326), Expect = 4e-30
Identities = 102/355 (28%), Positives = 158/355 (44%), Gaps = 69/355 (19%)
Query: 213 GLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGG------RAQELTEAFADVI 266
GL NLGNTCFLNA +QCL+ T PL ++ L ++ + G + +AFA+
Sbjct: 123 GLHNLGNTCFLNATIQCLTYTPPLANYLLSKEHARSCHQGSFCMLCVMQNHIVQAFAN-- 180
Query: 267 GALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPP 326
S A+ P F +K F +Q+DA EFL+ ++ +
Sbjct: 181 -------SGNAIKPVSFIRDLKKIARHFRFGNQEDAHEFLRYTIDAMQ------------ 221
Query: 327 ILANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSK---IVDLFVGQLKSCLK 383
+A L L+R+ + +F G L+S +K
Sbjct: 222 ---------------------------KACLNGCAKLDRQTQATTLVHQIFGGYLRSRVK 254
Query: 384 CQACGYRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQK 443
C C S T++ + D++L I + ++ LF K + L ENA +C +C++K
Sbjct: 255 CSVCKSVSDTYDPYLDVALEIRQAA------NIVRALELFVKADVLSGENAYMCAKCKKK 308
Query: 444 TRSTKKLTVQRFPRILVLHLNRFSASRGSIKKSSVGVDFPLQRLSLGDFASDKAGSPV-Y 502
++K+ T+ R +L L L RF+ G K + V +P + L++ + S G PV Y
Sbjct: 309 VPASKRFTIHRTSNVLTLSLKRFANFSGG--KITKDVGYP-EFLNIRPYMSQNNGDPVMY 365
Query: 503 QLYALCNHSG-SVHYGHYTALCRCQTG-WHVYNDSRVSPVSENQVASSEGYVLFY 555
LYA+ HSG S H GHY + G W+ NDS V + V + + YVLFY
Sbjct: 366 GLYAVLVHSGYSCHAGHYYCYVKASNGQWYQMNDSLVHSSNVKVVLNQQAYVLFY 420
>gi|14149627 ubiquitin specific peptidase 15 [Homo sapiens]
Length = 952
Score = 128 bits (321), Expect = 2e-29
Identities = 77/202 (38%), Positives = 111/202 (54%), Gaps = 21/202 (10%)
Query: 210 GHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEV----PGGGRAQELTEAFADV 265
G GL NLGNTCF+N+ +QCLS+T PL ++ L +++E+ P G R E+ +++A++
Sbjct: 258 GLCGLSNLGNTCFMNSAIQCLSNTPPLTEYFLNDKYQEELNFDNPLGMRG-EIAKSYAEL 316
Query: 266 IGALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAP 325
I +W V P F+ ++ P FSGY QQD QE L L++ LH ++NR R+ P
Sbjct: 317 IKQMWS-GKFSYVTPRAFKTQVGRFAPQFSGYQQQDCQELLAFLLDGLHEDLNRI-RKKP 374
Query: 326 PILANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQ 385
I P + + EE W+ +L+R DS IVD+F G KS L C
Sbjct: 375 YIQLKDADGRPDK---VVAEEA-----------WENHLKRNDSIIVDIFHGLFKSTLVCP 420
Query: 386 ACGYRSTTFEVFCDLSLPIPKK 407
C S TF+ FC L+LP+P K
Sbjct: 421 ECAKISVTFDPFCYLTLPLPMK 442
Score = 116 bits (290), Expect = 6e-26
Identities = 65/155 (41%), Positives = 90/155 (58%), Gaps = 7/155 (4%)
Query: 405 PKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLN 464
PKK F V L+DC LFT +E+L +E+ C C++ ++TKKL + P +LV+HL
Sbjct: 752 PKKPF----VKLKDCIELFTTKEKLGAEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLK 807
Query: 465 RFSASRGSIKKSSVGVDFPLQRLSLGDF-ASDKAGSPVYQLYALCNHSGSVHYGHYTALC 523
RFS SR K VDFP+ L + +F + AG Y L A+ NH G + GHYTA
Sbjct: 808 RFSYSRYMRDKLDTLVDFPINDLDMSEFLINPNAGPCRYNLIAVSNHYGGMGGGHYTAFA 867
Query: 524 RCQTG--WHVYNDSRVSPVSENQVASSEGYVLFYQ 556
+ + W+ ++DS VS SE+Q+ S YVLFYQ
Sbjct: 868 KNKDDGKWYYFDDSSVSTASEDQIVSKAAYVLFYQ 902
>gi|40795665 ubiquitin specific protease 4 isoform a [Homo sapiens]
Length = 963
Score = 127 bits (320), Expect = 2e-29
Identities = 77/201 (38%), Positives = 105/201 (52%), Gaps = 19/201 (9%)
Query: 210 GHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGG---GRAQELTEAFADVI 266
G GL NLGNTCF+N+ LQCLS+T PL D+ L+ ++ E+ G E+ EA+A++I
Sbjct: 300 GLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAELI 359
Query: 267 GALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPP 326
+W V P F+ ++ P FSGY QQD+QE L L++ LH ++NR ++ P
Sbjct: 360 KQMWSGRDAH-VAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKK--P 416
Query: 327 ILANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQA 386
L P D A W+ + R DS IVD F G KS L C
Sbjct: 417 YLELKDANGRP-------------DAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPE 463
Query: 387 CGYRSTTFEVFCDLSLPIPKK 407
C S TF+ FC L+LP+P K
Sbjct: 464 CAKVSVTFDPFCYLTLPLPLK 484
Score = 111 bits (277), Expect = 2e-24
Identities = 58/146 (39%), Positives = 87/146 (59%), Gaps = 3/146 (2%)
Query: 414 VSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSASRGSI 473
V+LRDC LFT E L + C C++ ++TKK + P+ILV+HL RFS +R
Sbjct: 776 VALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWR 835
Query: 474 KKSSVGVDFPLQRLSLGDFASDKAGSP-VYQLYALCNHSGSVHYGHYTALCRCQTG--WH 530
K V+FP++ L++ +F + + P VY L A+ NH G++ GHYTA + + W+
Sbjct: 836 DKLDTVVEFPIRGLNMSEFVCNLSARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKWY 895
Query: 531 VYNDSRVSPVSENQVASSEGYVLFYQ 556
++DS VS SE+Q+ + YVLFYQ
Sbjct: 896 YFDDSNVSLASEDQIVTKAAYVLFYQ 921
>gi|40795667 ubiquitin specific protease 4 isoform b [Homo sapiens]
Length = 916
Score = 127 bits (320), Expect = 2e-29
Identities = 77/201 (38%), Positives = 105/201 (52%), Gaps = 19/201 (9%)
Query: 210 GHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGG---GRAQELTEAFADVI 266
G GL NLGNTCF+N+ LQCLS+T PL D+ L+ ++ E+ G E+ EA+A++I
Sbjct: 253 GLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAELI 312
Query: 267 GALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPP 326
+W V P F+ ++ P FSGY QQD+QE L L++ LH ++NR ++ P
Sbjct: 313 KQMWSGRDAH-VAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKK--P 369
Query: 327 ILANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQA 386
L P D A W+ + R DS IVD F G KS L C
Sbjct: 370 YLELKDANGRP-------------DAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPE 416
Query: 387 CGYRSTTFEVFCDLSLPIPKK 407
C S TF+ FC L+LP+P K
Sbjct: 417 CAKVSVTFDPFCYLTLPLPLK 437
Score = 111 bits (277), Expect = 2e-24
Identities = 58/146 (39%), Positives = 87/146 (59%), Gaps = 3/146 (2%)
Query: 414 VSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSASRGSI 473
V+LRDC LFT E L + C C++ ++TKK + P+ILV+HL RFS +R
Sbjct: 729 VALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWR 788
Query: 474 KKSSVGVDFPLQRLSLGDFASDKAGSP-VYQLYALCNHSGSVHYGHYTALCRCQTG--WH 530
K V+FP++ L++ +F + + P VY L A+ NH G++ GHYTA + + W+
Sbjct: 789 DKLDTVVEFPIRGLNMSEFVCNLSARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKWY 848
Query: 531 VYNDSRVSPVSENQVASSEGYVLFYQ 556
++DS VS SE+Q+ + YVLFYQ
Sbjct: 849 YFDDSNVSLASEDQIVTKAAYVLFYQ 874
>gi|223005906 X-linked ubiquitin thioesterase 27 [Homo sapiens]
Length = 438
Score = 126 bits (317), Expect = 5e-29
Identities = 104/380 (27%), Positives = 158/380 (41%), Gaps = 77/380 (20%)
Query: 213 GLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRAQ--ELTEAFADVIGALW 270
GL NLGNTCF+N ++Q L+ T LRDF L R E+P E++ F ++
Sbjct: 79 GLINLGNTCFMNCIVQALTHTPILRDFFLSDRHRCEMPSPELCLVCEMSSLFRELYSGNP 138
Query: 271 HPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPPILAN 330
P P + + + +GY QQDA EFL ++ LH R + +
Sbjct: 139 SPHV-----PYKLLHLVWIHARHLAGYRQQDAHEFLIAALDVLH-----RHCKGDDV--- 185
Query: 331 GPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQACGYR 390
G + P ++++ +F G L+S + CQAC
Sbjct: 186 GKAANNPNHCNCIIDQ--------------------------IFTGGLQSDVTCQACHGV 219
Query: 391 STTFEVFCDLSLPIPK------------------KGFAGGKVSLRDCFNLFTKEEELESE 432
STT + D+SL +P + G +L DC FT+ E L S
Sbjct: 220 STTIDPCWDISLDLPGSCTSFWPMSPGRESSVNGESHIPGITTLTDCLRRFTRPEHLGSS 279
Query: 433 NAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSASRGSIKKSSVGVDFPLQRLSLGDF 492
C C+ STK+LT+ + P + H RF S +K + + FPL+ L + F
Sbjct: 280 AKIKCGSCQSYQESTKQLTMNKLPVVACFHFKRFEHSAKQRRKITTYISFPLE-LDMTPF 338
Query: 493 ASDKAGSPV----------------YQLYALCNHSGSVHYGHYTALCR-CQTGWHVYNDS 535
+ S + Y L+A+ NH G++ GHYT+ R + W +D+
Sbjct: 339 MASSKESRMNGQLQLPTNSGNNENKYSLFAVVNHQGTLESGHYTSFIRHHKDQWFKCDDA 398
Query: 536 RVSPVSENQVASSEGYVLFY 555
++ S V SEGY+LFY
Sbjct: 399 VITKASIKDVLDSEGYLLFY 418
>gi|57529246 ubiquitin thioesterase 19 [Homo sapiens]
Length = 1318
Score = 124 bits (312), Expect = 2e-28
Identities = 78/201 (38%), Positives = 105/201 (52%), Gaps = 19/201 (9%)
Query: 210 GHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGG---GRAQELTEAFADVI 266
G GL NLGNTCF+N+V+Q LS+TR LRDF R F E+ G L FA ++
Sbjct: 495 GFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHDRSFEAEINYNNPLGTGGRLAIGFAVLL 554
Query: 267 GALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPP 326
ALW + A P++ +A+ F+GY+Q DAQEF+ L++ LH ++NR
Sbjct: 555 RALW-KGTHHAFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLLDGLHEDLNR------- 606
Query: 327 ILANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQA 386
+ N P G D+ A W+R+ R DS IVDLF GQ KS L C
Sbjct: 607 -IQNKPYTETVDSDGR-------PDEVVAEEAWQRHKMRNDSFIVDLFQGQYKSKLVCPV 658
Query: 387 CGYRSTTFEVFCDLSLPIPKK 407
C S TF+ F L +P+P+K
Sbjct: 659 CAKVSITFDPFLYLPVPLPQK 679
Score = 104 bits (259), Expect = 2e-22
Identities = 62/169 (36%), Positives = 90/169 (53%), Gaps = 18/169 (10%)
Query: 412 GKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSASRG 471
G +L C NLFT+ E L E A C +C+Q ++K+L + R P +L++ L RFS R
Sbjct: 1056 GHFTLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVLIVQLKRFS-FRS 1114
Query: 472 SIKKSSVG--VDFPLQRLSLGDF--ASDKAGSPVYQLYALCNHSGSVHYGHYTALC---- 523
I + + V+FP++ L L F + P Y LYA+ NH G + GHYTA
Sbjct: 1115 FIWRDKINDLVEFPVRNLDLSKFCIGQKEEQLPSYDLYAVINHYGGMIGGHYTACARLPN 1174
Query: 524 -----RCQTGWHVYNDSRVSPVSENQVASSEGYVLFYQL----MQEPPR 563
R GW +++DS V+ V E+QV + YVLFY+ ++ PPR
Sbjct: 1175 DRSSQRSDVGWRLFDDSTVTTVDESQVVTRYAYVLFYRRRNSPVERPPR 1223
>gi|79750944 ubiquitin specific peptidase 42 [Homo sapiens]
Length = 1316
Score = 124 bits (310), Expect = 3e-28
Identities = 100/349 (28%), Positives = 152/349 (43%), Gaps = 57/349 (16%)
Query: 213 GLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRAQELTEAFADVIGALWHP 272
GL+NLGNTCF NA LQCL+ T PL ++ L + + G T A + AL +P
Sbjct: 112 GLQNLGNTCFANAALQCLTYTPPLANYMLSHEHSKTCHAEGFCMMCTMQ-AHITQALSNP 170
Query: 273 DSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPPILANGP 332
+ + P ++ F +Q+DA EFL+ ++ +
Sbjct: 171 G--DVIKPMFVINEMRRIARHFRFGNQEDAHEFLQYTVDAMQ------------------ 210
Query: 333 VPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSK---IVDLFVGQLKSCLKCQACGY 389
+A L L+R + +F G L+S +KC C
Sbjct: 211 ---------------------KACLNGSNKLDRHTQATTLVCQIFGGYLRSRVKCLNCKG 249
Query: 390 RSTTFEVFCDLSLPIPKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKK 449
S TF+ + D++L I S+ F K E+L+ EN+ C +C++ ++K+
Sbjct: 250 VSDTFDPYLDITLEIK------AAQSVNKALEQFVKPEQLDGENSYKCSKCKKMVPASKR 303
Query: 450 LTVQRFPRILVLHLNRFSASRGSIKKSSVGVDFPLQRLSLGDFASDKAGSP-VYQLYALC 508
T+ R +L L L RF+ G K + V +P + L + + S G P VY LYA+
Sbjct: 304 FTIHRSSNVLTLSLKRFANFTGG--KIAKDVKYP-EYLDIRPYMSQPNGEPIVYVLYAVL 360
Query: 509 NHSG-SVHYGHYTALCRCQTG-WHVYNDSRVSPVSENQVASSEGYVLFY 555
H+G + H GHY + G W+ NDS VS V S + YVLFY
Sbjct: 361 VHTGFNCHAGHYFCYIKASNGLWYQMNDSIVSTSDIRSVLSQQAYVLFY 409
>gi|41152235 ubiquitin specific protease 51 [Homo sapiens]
Length = 711
Score = 120 bits (300), Expect = 4e-27
Identities = 105/381 (27%), Positives = 156/381 (40%), Gaps = 79/381 (20%)
Query: 213 GLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFR--QEVPGGGRAQELTEAFADVIGALW 270
GL NLGNTCF+N ++Q L+ L+DF L + P E++ F +
Sbjct: 364 GLINLGNTCFMNCIVQALTHIPLLKDFFLSDKHKCIMTSPSLCLVCEMSSLFHAMYSGSR 423
Query: 271 HPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPPILAN 330
P P + + + +GY QQDA EFL +++ LH
Sbjct: 424 TPHI-----PYKLLHLIWIHAEHLAGYRQQDAHEFLIAILDVLHRH-------------- 464
Query: 331 GPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVD-LFVGQLKSCLKCQACGY 389
S GG P + I+D +F G L+S + CQAC
Sbjct: 465 ----SKDDSGGQEANNPNCCNC-----------------IIDQIFTGGLQSDVTCQACHS 503
Query: 390 RSTTFEVFCDLSLPIP-------------------KKGFAGGKVSLRDCFNLFTKEEELE 430
STT + D+SL +P + G SL DC FT+ E L
Sbjct: 504 VSTTIDPCWDISLDLPGSCATFDSQNPERADSTVSRDDHIPGIPSLTDCLQWFTRPEHLG 563
Query: 431 SENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSASRGSIKKSSVGVDFPLQRLSLG 490
S C+ C+ STK+LT+++ P + HL RF +K + + FPL+ L +
Sbjct: 564 SSAKIKCNSCQSYQESTKQLTMKKLPIVACFHLKRFEHVGKQRRKINTFISFPLE-LDMT 622
Query: 491 DFASD------KAGSP---------VYQLYALCNHSGSVHYGHYTALCRCQTG-WHVYND 534
F + K G P Y L+A+ NH G++ GHYT+ R Q W +D
Sbjct: 623 PFLASTKESRMKEGQPPTDCVPNENKYSLFAVINHHGTLESGHYTSFIRQQKDQWFSCDD 682
Query: 535 SRVSPVSENQVASSEGYVLFY 555
+ ++ + + SEGY+LFY
Sbjct: 683 AIITKATIEDLLYSEGYLLFY 703
Score = 31.6 bits (70), Expect = 2.0
Identities = 23/67 (34%), Positives = 29/67 (43%), Gaps = 1/67 (1%)
Query: 31 PRARSKERRNPASGPNPMLRPLPPRPGLPDERLK-KLELGRGRTSGPRPRGPLRADHGVP 89
PRARS+ + ++ P P RP PP P P + + G R S P R R
Sbjct: 110 PRARSRSQPGLSAPPPPPARPPPPPPPPPPPAPRPRAWRGSRRRSRPGSRPQTRRSCSGD 169
Query: 90 LPGSPPP 96
L GS P
Sbjct: 170 LDGSGDP 176
>gi|42516561 ubiquitin specific protease 33 isoform 3 [Homo sapiens]
Length = 828
Score = 118 bits (295), Expect = 2e-26
Identities = 96/341 (28%), Positives = 140/341 (41%), Gaps = 55/341 (16%)
Query: 275 CEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLE----INRRGRRAPPILAN 330
C +N F K S S + QE +K+ + E ++ P IL +
Sbjct: 369 CNKINKVNSEGEFDKDRDSISETVDLNNQETVKVQIHSRASEYITDVHSNDLSTPQILPS 428
Query: 331 GPVPSP-----PRRGGALLE--EPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLK 383
+P P + G L P A+ K+ ++ S I D+F G + S ++
Sbjct: 429 NEGVNPRLSASPPKSGNLWPGLAPPHKKAQSASPKRKKQHKKYRSVISDIFDGTIISSVQ 488
Query: 384 CQACGYRSTTFEVFCDLSLPIP-------------------------------------- 405
C C S T E F DLSLPIP
Sbjct: 489 CLTCDRVSVTLETFQDLSLPIPGKEDLAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFME 548
Query: 406 --KKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHL 463
K F G V+L+DC F +EL+ +N C++C++ K VQ FP IL +HL
Sbjct: 549 YVKSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHL 608
Query: 464 NRFSASRGSIKKSSVGVDFPLQRLSLGDFASDKAGSPV--YQLYALCNHSGSVHYGHYTA 521
RF K S V FPL+ L L F + + + + Y L ++ H G+ GHY A
Sbjct: 609 KRFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIA 668
Query: 522 LCRCQTG--WHVYNDSRVSPVSENQVASSEGYVLFYQLMQE 560
CR W+ ++D V+ VSE+ V ++E YVLFY+ E
Sbjct: 669 YCRNNLNNLWYEFDDQSVTEVSESTVQNAEAYVLFYRKSSE 709
Score = 78.6 bits (192), Expect = 1e-14
Identities = 45/118 (38%), Positives = 65/118 (55%), Gaps = 9/118 (7%)
Query: 206 LLGSGHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRAQE---LTEAF 262
L G GL+N+GNTC++NA LQ LS+ PL F L + G R + + +++
Sbjct: 179 LRARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFL------DCGGLARTDKKPAICKSY 232
Query: 263 ADVIGALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRR 320
++ LWH +V PT + P+F GYSQQDAQEFL+ LM+ LH E+ +
Sbjct: 233 LKLMTELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKEQ 290
>gi|239742282 PREDICTED: hypothetical protein XP_002342474 [Homo
sapiens]
Length = 530
Score = 118 bits (295), Expect = 2e-26
Identities = 101/346 (29%), Positives = 156/346 (45%), Gaps = 57/346 (16%)
Query: 213 GLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRAQELTEAFADVIGALWHP 272
GL+N+GNTC++NA LQCL+ T PL ++ L R+ Q + L A + AL +P
Sbjct: 81 GLQNMGNTCYVNASLQCLTYTPPLANYMLSREHSQTCHRH-KGCMLCTMQAHITRALHNP 139
Query: 273 DSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPPILANGP 332
+ P+ Q F Q+DA EFL ++ +
Sbjct: 140 G--HVIQPS------QALAAGFHRGKQEDAHEFLMFTVDAMK---------------KAC 176
Query: 333 VPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQACGYRST 392
+P G ++ P ++ + I +F G +S +KC C S
Sbjct: 177 LP-----GHKQVDHPS----------------KDTTLIHQIFGGYWRSQIKCLHCHGISD 215
Query: 393 TFEVFCDLSLPIPKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTV 452
TF+ + D++L I S++ K EEL ENA C C Q+ ++K LT+
Sbjct: 216 TFDPYLDIALDIQ------AAQSVQQALEQLVKPEELNGENAYHCGVCLQRAPASKTLTL 269
Query: 453 QRFPRILVLHLNRFSASRGSIKKSSVGVDFPLQRLSLGDFASDKAGSP-VYQLYALCNHS 511
++L+L L RFS G+ K + V +P + L + + S + P VY LYA+ H+
Sbjct: 270 HTSAKVLILVLKRFSDVTGN--KIAKNVQYP-ECLDMQPYMSQQNTGPLVYVLYAVLVHA 326
Query: 512 G-SVHYGHYTALCRCQTG-WHVYNDSRVSPVSENQVASSEGYVLFY 555
G S H GHY + + Q G W+ +D+ V+ S V S + YVLFY
Sbjct: 327 GWSCHNGHYFSYVKAQEGQWYKMDDAEVTAASITSVLSQQAYVLFY 372
>gi|22550104 ubiquitin specific protease 32 [Homo sapiens]
Length = 1604
Score = 118 bits (295), Expect = 2e-26
Identities = 74/225 (32%), Positives = 111/225 (49%), Gaps = 35/225 (15%)
Query: 196 SDDKMAHHTLLLGSGHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGG--- 252
+ K+ H + G GL NLGNTCF+N+ +QC+S+T+PL + + E+
Sbjct: 718 NSSKIDRHKVPTEKGATGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPI 777
Query: 253 GRAQELTEAFADVIGALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMER 312
G + + + D++ LW + V P + R KY P F+G+ QQD+QE L L++
Sbjct: 778 GMKGHMAKCYGDLVQELWSGTQ-KNVAPLKLRWTIAKYAPRFNGFQQQDSQELLAFLLDG 836
Query: 313 LHLEINRRGRRAPPILANGPVPSPPRRGGALLEEP--ELSDDDR------ANLMWKRYLE 364
LH ++NR + E+P EL D D A W +L
Sbjct: 837 LHEDLNR-----------------------VHEKPYVELKDSDGRPDWEVAAEAWDNHLR 873
Query: 365 REDSKIVDLFVGQLKSCLKCQACGYRSTTFEVFCDLSLPIPKKGF 409
R S +VDLF GQL+S +KC+ CG+ S F+ F LSLP+P +
Sbjct: 874 RNRSIVVDLFHGQLRSQVKCKTCGHISVRFDPFNFLSLPLPMDSY 918
Score = 56.2 bits (134), Expect = 8e-08
Identities = 34/97 (35%), Positives = 46/97 (47%), Gaps = 7/97 (7%)
Query: 414 VSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSASRGSI 473
++L C FT EEEL C +C+ +TKKL + R P IL++HL RF G
Sbjct: 1233 INLDSCLRAFTSEEELGENEMYYCSKCKTHCLATKKLDLWRLPPILIIHLKRFQFVNGRW 1292
Query: 474 KKSSVGVDFPLQRLSLGDFASDKAGSPVYQLYALCNH 510
KS V FP + + D + V + ALC H
Sbjct: 1293 IKSQKIVKFPRE-------SFDPSAFLVPRDPALCQH 1322
Score = 49.3 bits (116), Expect = 9e-06
Identities = 24/72 (33%), Positives = 37/72 (51%), Gaps = 5/72 (6%)
Query: 488 SLGDFASDKAGSPVYQLYALCNHSGSVHYGHYTALCR---CQTGWHVYNDSRVSPVSENQ 544
S D D P+Y LYA+ HSG + GHY + C+ W+ YNDS + ++
Sbjct: 1496 STDDQREDTRIKPIYNLYAISCHSGILGGGHYVTYAKNPNCK--WYCYNDSSCKELHPDE 1553
Query: 545 VASSEGYVLFYQ 556
+ + Y+LFY+
Sbjct: 1554 IDTDSAYILFYE 1565
>gi|109638751 ubiquitin specific protease 6 [Homo sapiens]
Length = 1406
Score = 117 bits (294), Expect = 2e-26
Identities = 73/211 (34%), Positives = 106/211 (50%), Gaps = 35/211 (16%)
Query: 210 GHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGG---GRAQELTEAFADVI 266
G GL NLGNTCF+N+ +QC+S+T+PL + + E+ G + + + D++
Sbjct: 530 GATGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPIGMKGHMAKCYGDLV 589
Query: 267 GALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPP 326
LW ++V P + R KY P F G+ QQD+QE L L++ LH ++NR
Sbjct: 590 QELWSGTQ-KSVAPLKLRRTIAKYAPKFDGFQQQDSQELLAFLLDGLHEDLNR------- 641
Query: 327 ILANGPVPSPPRRGGALLEEP--ELSDDDR------ANLMWKRYLEREDSKIVDLFVGQL 378
+ E+P EL D D A W +L R S IVDLF GQL
Sbjct: 642 ----------------VHEKPYVELKDSDGRPDWEVAAEAWDNHLRRNRSIIVDLFHGQL 685
Query: 379 KSCLKCQACGYRSTTFEVFCDLSLPIPKKGF 409
+S +KC+ CG+ S F+ F LSLP+P +
Sbjct: 686 RSQVKCKTCGHISVRFDPFNFLSLPLPMDSY 716
Score = 48.9 bits (115), Expect = 1e-05
Identities = 24/72 (33%), Positives = 37/72 (51%), Gaps = 5/72 (6%)
Query: 488 SLGDFASDKAGSPVYQLYALCNHSGSVHYGHYTALCR---CQTGWHVYNDSRVSPVSENQ 544
S D D P+Y LYA+ HSG + GHY + C+ W+ YNDS + ++
Sbjct: 1298 STDDQREDTHIKPIYNLYAISCHSGILSGGHYITYAKNPNCK--WYCYNDSSCEELHPDE 1355
Query: 545 VASSEGYVLFYQ 556
+ + Y+LFY+
Sbjct: 1356 IDTDSAYILFYE 1367
Score = 48.5 bits (114), Expect = 2e-05
Identities = 21/53 (39%), Positives = 29/53 (54%)
Query: 414 VSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRF 466
++L C FT EEEL C +C+ +TKKL + R P L++HL RF
Sbjct: 1031 INLDSCLRAFTSEEELGESEMYYCSKCKTHCLATKKLDLWRLPPFLIIHLKRF 1083
>gi|169217654 PREDICTED: similar to deubiquitinating enzyme DUB1
[Homo sapiens]
Length = 530
Score = 117 bits (293), Expect = 3e-26
Identities = 101/346 (29%), Positives = 156/346 (45%), Gaps = 57/346 (16%)
Query: 213 GLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRAQELTEAFADVIGALWHP 272
GL+N+GNTC++NA LQCL+ T PL ++ L R+ Q + L A + AL +P
Sbjct: 81 GLQNMGNTCYVNASLQCLTYTPPLANYMLSREHSQTCHRH-KGCMLCTMQAHITRALHNP 139
Query: 273 DSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPPILANGP 332
+ P+ Q F Q+DA EFL ++ +
Sbjct: 140 G--HVIQPS------QALAAGFHRGKQEDAHEFLMFTVDAMKK----------------- 174
Query: 333 VPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQACGYRST 392
A L + +D + ++ + I +F G +S +KC C S
Sbjct: 175 ---------ACLPGHKQAD----------HHSKDTTLIHQIFGGYWRSQIKCLHCHGISD 215
Query: 393 TFEVFCDLSLPIPKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTV 452
TF+ + D++L I S++ K EEL ENA C C Q+ ++K LT+
Sbjct: 216 TFDPYLDIALDIQ------AAQSVQQALEQLVKPEELNGENAYHCGVCLQRAPASKTLTL 269
Query: 453 QRFPRILVLHLNRFSASRGSIKKSSVGVDFPLQRLSLGDFASDKAGSP-VYQLYALCNHS 511
++L+L L RFS G+ K + V +P + L + + S + P VY LYA+ H+
Sbjct: 270 HTSAKVLILVLKRFSDVTGN--KIAKNVQYP-ECLDMQPYMSQQNTGPLVYVLYAVLVHA 326
Query: 512 G-SVHYGHYTALCRCQTG-WHVYNDSRVSPVSENQVASSEGYVLFY 555
G S H GHY + + Q G W+ +D+ V+ S V S + YVLFY
Sbjct: 327 GWSCHNGHYFSYVKAQEGQWYKMDDAEVTASSITSVLSQQAYVLFY 372
>gi|197116355 ubiquitin specific peptidase 46 isoform 2 [Homo
sapiens]
Length = 359
Score = 117 bits (292), Expect = 4e-26
Identities = 100/365 (27%), Positives = 158/365 (43%), Gaps = 54/365 (14%)
Query: 211 HVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRAQELTEAFADVIGAL- 269
+ GL N GNTC+ N+VLQ L RP R+ L +Q+ + + L AD+ ++
Sbjct: 27 YFGLVNFGNTCYCNSVLQALYFCRPFRENVLAYKAQQK-----KKENLLTCLADLFHSIA 81
Query: 270 WHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLH--LEINRRGRRAPPI 327
+ P +F + +K F Y QQDA EFL L+ + L+ ++ +
Sbjct: 82 TQKKKVGVIPPKKFISRLRKENDLFDNYMQQDAHEFLNYLLNTIADILQEEKKQEKQNGK 141
Query: 328 LANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQAC 387
L NG + P +++++ L W + ++F G L + +C C
Sbjct: 142 LKNGNMNEP-------------AENNKPELTW----------VHEIFQGTLTNETRCLNC 178
Query: 388 GYRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRST 447
S+ E F DLS+ + + S+ C F+ E L SE C+ C K +
Sbjct: 179 ETVSSKDEDFLDLSVDVEQN------TSITHCLRDFSNTETLCSEQKYYCETCCSKQEAQ 232
Query: 448 KKLTVQRFPRILVLHLNRFS--ASRGSIKKSSVGVDFPLQRLSLGDFASDKAG-SPVYQL 504
K++ V++ P IL LHL RF K S V FPL+ L L + +SD +Y L
Sbjct: 233 KRMRVKKLPMILALHLKRFKYMEQLHRYTKLSYRVVFPLE-LRLFNTSSDAVNLDRMYDL 291
Query: 505 YALCNHSGS-VHYGHYTALCRCQTGWHVYNDSRVSPVSENQVA------------SSEGY 551
A+ H GS + GHY + + W +++D V + + S GY
Sbjct: 292 VAVVVHCGSGPNRGHYITIVKSHGFWLLFDDDIVEKIDAQAIEEFYGLTSDISKNSESGY 351
Query: 552 VLFYQ 556
+LFYQ
Sbjct: 352 ILFYQ 356
>gi|31377709 ubiquitin specific peptidase 46 isoform 1 [Homo
sapiens]
Length = 366
Score = 117 bits (292), Expect = 4e-26
Identities = 100/365 (27%), Positives = 158/365 (43%), Gaps = 54/365 (14%)
Query: 211 HVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRAQELTEAFADVIGAL- 269
+ GL N GNTC+ N+VLQ L RP R+ L +Q+ + + L AD+ ++
Sbjct: 34 YFGLVNFGNTCYCNSVLQALYFCRPFRENVLAYKAQQK-----KKENLLTCLADLFHSIA 88
Query: 270 WHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLH--LEINRRGRRAPPI 327
+ P +F + +K F Y QQDA EFL L+ + L+ ++ +
Sbjct: 89 TQKKKVGVIPPKKFISRLRKENDLFDNYMQQDAHEFLNYLLNTIADILQEEKKQEKQNGK 148
Query: 328 LANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQAC 387
L NG + P +++++ L W + ++F G L + +C C
Sbjct: 149 LKNGNMNEP-------------AENNKPELTW----------VHEIFQGTLTNETRCLNC 185
Query: 388 GYRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRST 447
S+ E F DLS+ + + S+ C F+ E L SE C+ C K +
Sbjct: 186 ETVSSKDEDFLDLSVDVEQN------TSITHCLRDFSNTETLCSEQKYYCETCCSKQEAQ 239
Query: 448 KKLTVQRFPRILVLHLNRFS--ASRGSIKKSSVGVDFPLQRLSLGDFASDKAG-SPVYQL 504
K++ V++ P IL LHL RF K S V FPL+ L L + +SD +Y L
Sbjct: 240 KRMRVKKLPMILALHLKRFKYMEQLHRYTKLSYRVVFPLE-LRLFNTSSDAVNLDRMYDL 298
Query: 505 YALCNHSGS-VHYGHYTALCRCQTGWHVYNDSRVSPVSENQVA------------SSEGY 551
A+ H GS + GHY + + W +++D V + + S GY
Sbjct: 299 VAVVVHCGSGPNRGHYITIVKSHGFWLLFDDDIVEKIDAQAIEEFYGLTSDISKNSESGY 358
Query: 552 VLFYQ 556
+LFYQ
Sbjct: 359 ILFYQ 363
>gi|239742287 PREDICTED: hypothetical protein XP_002342475 [Homo
sapiens]
Length = 530
Score = 117 bits (292), Expect = 4e-26
Identities = 101/346 (29%), Positives = 155/346 (44%), Gaps = 57/346 (16%)
Query: 213 GLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRAQELTEAFADVIGALWHP 272
GL+N+GNTC++NA LQCL+ T PL ++ L R+ Q + L A + AL +P
Sbjct: 81 GLQNMGNTCYVNASLQCLTYTPPLANYMLSREHSQTCHRH-KGCMLCTMQAHITRALHNP 139
Query: 273 DSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPPILANGP 332
+ P+ Q F Q+DA EFL ++ +
Sbjct: 140 G--HVIQPS------QALAAGFHRGKQEDAHEFLMFTVDAMKK----------------- 174
Query: 333 VPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQACGYRST 392
A L + D + ++ + I +F G +S +KC C S
Sbjct: 175 ---------ACLPGHKQVD----------HHSKDTTLIHQIFGGYWRSQIKCLHCHGISD 215
Query: 393 TFEVFCDLSLPIPKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTV 452
TF+ + D++L I S++ K EEL ENA C C Q+ ++K LT+
Sbjct: 216 TFDPYLDIALDIQ------AAQSVQQALEQLVKPEELNGENAYHCGVCLQRAPASKTLTL 269
Query: 453 QRFPRILVLHLNRFSASRGSIKKSSVGVDFPLQRLSLGDFASDKAGSP-VYQLYALCNHS 511
++L+L L RFS G+ K + V +P + L + + S + P VY LYA+ H+
Sbjct: 270 HTSAKVLILVLKRFSDVTGN--KIAKNVQYP-ECLDMQPYMSQQNTGPLVYVLYAVLVHA 326
Query: 512 G-SVHYGHYTALCRCQTG-WHVYNDSRVSPVSENQVASSEGYVLFY 555
G S H GHY + + Q G W+ +D+ V+ S V S + YVLFY
Sbjct: 327 GWSCHNGHYFSYVKAQEGQWYKMDDAEVTAASITSVLSQQAYVLFY 372
>gi|239758075 PREDICTED: similar to deubiquitinating enzyme DUB1
[Homo sapiens]
Length = 530
Score = 116 bits (290), Expect = 6e-26
Identities = 101/346 (29%), Positives = 155/346 (44%), Gaps = 57/346 (16%)
Query: 213 GLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRAQELTEAFADVIGALWHP 272
GL+N+GNTC++NA LQCL+ T PL ++ L R+ Q + L A + AL +P
Sbjct: 81 GLQNMGNTCYVNASLQCLTYTPPLANYMLSREHSQTCHRH-KGCMLCTMQAHITRALHNP 139
Query: 273 DSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPPILANGP 332
+ P+ Q F Q+DA EFL ++ +
Sbjct: 140 G--HVIQPS------QALAAGFHRGKQEDAHEFLMFTVDAMKK----------------- 174
Query: 333 VPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQACGYRST 392
A L + D + ++ + I +F G +S +KC C S
Sbjct: 175 ---------ACLPGHKQVD----------HHSKDTTLIHQIFGGYWRSQIKCLHCHGISD 215
Query: 393 TFEVFCDLSLPIPKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTV 452
TF+ + D++L I S++ K EEL ENA C C Q+ ++K LT+
Sbjct: 216 TFDPYLDIALDIQ------AAQSVQQALEQLVKPEELNGENAYHCGVCLQRAPASKTLTL 269
Query: 453 QRFPRILVLHLNRFSASRGSIKKSSVGVDFPLQRLSLGDFASDKAGSP-VYQLYALCNHS 511
++L+L L RFS G+ K + V +P + L + + S + P VY LYA+ H+
Sbjct: 270 HTSAKVLILVLKRFSDVTGN--KIAKNVQYP-ECLDMQPYMSQQNTGPLVYVLYAVLVHA 326
Query: 512 G-SVHYGHYTALCRCQTG-WHVYNDSRVSPVSENQVASSEGYVLFY 555
G S H GHY + + Q G W+ +D+ V+ S V S + YVLFY
Sbjct: 327 GWSCHNGHYFSYVKAQEGQWYKMDDAEVTASSITSVLSQQAYVLFY 372
>gi|239742297 PREDICTED: hypothetical protein XP_002342480 [Homo
sapiens]
Length = 530
Score = 116 bits (290), Expect = 6e-26
Identities = 101/346 (29%), Positives = 155/346 (44%), Gaps = 57/346 (16%)
Query: 213 GLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRAQELTEAFADVIGALWHP 272
GL+N+GNTC++NA LQCL+ T PL ++ L R+ Q + L A + AL +P
Sbjct: 81 GLQNMGNTCYVNASLQCLTYTPPLANYMLSREHSQTCHRH-KGCMLCTMQAHITRALHNP 139
Query: 273 DSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPPILANGP 332
+ P+ Q F Q+DA EFL ++ +
Sbjct: 140 G--HVIQPS------QALAAGFHRGKQEDAHEFLMFTVDAMKK----------------- 174
Query: 333 VPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQACGYRST 392
A L + D + ++ + I +F G +S +KC C S
Sbjct: 175 ---------ACLPGHKQVD----------HHSKDTTLIHQIFGGYWRSQIKCLHCHGISD 215
Query: 393 TFEVFCDLSLPIPKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTV 452
TF+ + D++L I S++ K EEL ENA C C Q+ ++K LT+
Sbjct: 216 TFDPYLDIALDIQ------AAQSVQQALEQLVKPEELNGENAYHCGVCLQRAPASKTLTL 269
Query: 453 QRFPRILVLHLNRFSASRGSIKKSSVGVDFPLQRLSLGDFASDKAGSP-VYQLYALCNHS 511
++L+L L RFS G+ K + V +P + L + + S + P VY LYA+ H+
Sbjct: 270 HTSAKVLILVLKRFSDVTGN--KIAKNVQYP-ECLDMQPYMSQQNTGPLVYVLYAVLVHA 326
Query: 512 G-SVHYGHYTALCRCQTG-WHVYNDSRVSPVSENQVASSEGYVLFY 555
G S H GHY + + Q G W+ +D+ V+ S V S + YVLFY
Sbjct: 327 GWSCHNGHYFSYVKAQEGQWYKMDDAEVTASSITSVLSQQAYVLFY 372
>gi|113415490 PREDICTED: similar to deubiquitinating enzyme 1 [Homo
sapiens]
Length = 530
Score = 115 bits (288), Expect = 1e-25
Identities = 101/346 (29%), Positives = 154/346 (44%), Gaps = 57/346 (16%)
Query: 213 GLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRAQELTEAFADVIGALWHP 272
GL+N+GNTC++NA LQCL+ T PL ++ L R+ Q + L A + AL +P
Sbjct: 81 GLQNMGNTCYVNASLQCLTYTPPLANYMLSREHSQTCHRH-KGCMLCTMQAHITRALHNP 139
Query: 273 DSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPPILANGP 332
+ P+ Q F Q+DA EFL ++ +
Sbjct: 140 G--HVIQPS------QALAAGFHRGKQEDAHEFLMFTVDAMKK----------------- 174
Query: 333 VPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQACGYRST 392
A L + D + ++ + I +F G +S +KC C S
Sbjct: 175 ---------ACLPGHKQVD----------HHSKDTTLIHQIFGGYWRSQIKCLHCHGISD 215
Query: 393 TFEVFCDLSLPIPKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTV 452
TF+ + D++L I S++ K EEL ENA C C Q+ ++K LT+
Sbjct: 216 TFDPYLDIALDIQ------AAQSVQQALEQLVKPEELNGENAYHCGVCLQRAPASKTLTL 269
Query: 453 QRFPRILVLHLNRFSASRGSIKKSSVGVDFPLQRLSLGDFASD-KAGSPVYQLYALCNHS 511
++L+L L RFS G+ K + V +P + L + + S G VY LYA+ H+
Sbjct: 270 HTSAKVLILVLKRFSDVTGN--KIAKNVQYP-ECLDMQPYMSQPNTGPLVYVLYAVLVHA 326
Query: 512 G-SVHYGHYTALCRCQTG-WHVYNDSRVSPVSENQVASSEGYVLFY 555
G S H GHY + + Q G W+ +D+ V+ S V S + YVLFY
Sbjct: 327 GWSCHNGHYFSYVKAQEGQWYKMDDAEVTASSITSVLSQQAYVLFY 372
>gi|113415488 PREDICTED: similar to deubiquitinating enzyme 1 [Homo
sapiens]
Length = 530
Score = 115 bits (288), Expect = 1e-25
Identities = 101/346 (29%), Positives = 154/346 (44%), Gaps = 57/346 (16%)
Query: 213 GLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRAQELTEAFADVIGALWHP 272
GL+N+GNTC++NA LQCL+ T PL ++ L R+ Q + L A + AL +P
Sbjct: 81 GLQNMGNTCYVNASLQCLTYTPPLANYMLSREHSQTCHRH-KGCMLCTMQAHITRALHNP 139
Query: 273 DSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPPILANGP 332
+ P+ Q F Q+DA EFL ++ +
Sbjct: 140 G--HVIQPS------QALAAGFHRGKQEDAHEFLMFTVDAMKK----------------- 174
Query: 333 VPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQACGYRST 392
A L + D + ++ + I +F G +S +KC C S
Sbjct: 175 ---------ACLPGHKQVD----------HHSKDTTLIHQIFGGYWRSQIKCLHCHGISD 215
Query: 393 TFEVFCDLSLPIPKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTV 452
TF+ + D++L I S++ K EEL ENA C C Q+ ++K LT+
Sbjct: 216 TFDPYLDIALDIQ------AAQSVQQALEQLVKPEELNGENAYHCGVCLQRAPASKTLTL 269
Query: 453 QRFPRILVLHLNRFSASRGSIKKSSVGVDFPLQRLSLGDFASD-KAGSPVYQLYALCNHS 511
++L+L L RFS G+ K + V +P + L + + S G VY LYA+ H+
Sbjct: 270 HTSAKVLILVLKRFSDVTGN--KIAKNVQYP-ECLDMQPYMSQPNTGPLVYVLYAVLVHA 326
Query: 512 G-SVHYGHYTALCRCQTG-WHVYNDSRVSPVSENQVASSEGYVLFY 555
G S H GHY + + Q G W+ +D+ V+ S V S + YVLFY
Sbjct: 327 GWSCHNGHYFSYVKAQEGQWYKMDDAEVTASSITSVLSQQAYVLFY 372
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.137 0.424
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,866,048
Number of Sequences: 37866
Number of extensions: 1555195
Number of successful extensions: 8527
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 130
Number of HSP's successfully gapped in prelim test: 416
Number of HSP's that attempted gapping in prelim test: 7144
Number of HSP's gapped (non-prelim): 1471
length of query: 565
length of database: 18,247,518
effective HSP length: 108
effective length of query: 457
effective length of database: 14,157,990
effective search space: 6470201430
effective search space used: 6470201430
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.