Search of human proteins with 73808268

Search of human proteins with 73808268

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|73808268 matrix metalloproteinase 27 [Homo sapiens]
         (513 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|73808268 matrix metalloproteinase 27 [Homo sapiens]               1068   0.0  
gi|4505217 matrix metalloproteinase 3 preproprotein [Homo sapiens]    483   e-136
gi|4505205 matrix metalloproteinase 10 preproprotein [Homo sapiens]   476   e-134
gi|4505215 matrix metalloproteinase 1 isoform 1 preproprotein [H...   450   e-126
gi|4505221 matrix metalloproteinase 8 preproprotein [Homo sapiens]    449   e-126
gi|4505209 matrix metalloproteinase 13 preproprotein [Homo sapiens]   441   e-123
gi|73858572 matrix metalloproteinase 12 preproprotein [Homo sapi...   439   e-123
gi|225543094 matrix metalloproteinase 1 isoform 2 [Homo sapiens]      415   e-116
gi|45359865 matrix metalloproteinase 20 preproprotein [Homo sapi...   371   e-103
gi|5729929 matrix metalloproteinase 24 preproprotein [Homo sapiens]   266   3e-71
gi|4505211 matrix metalloproteinase 15 preproprotein [Homo sapiens]   261   1e-69
gi|4826834 matrix metalloproteinase 14 preproprotein [Homo sapiens]   260   2e-69
gi|13027802 matrix metalloproteinase 16 isoform 1 preproprotein ...   259   5e-69
gi|4505219 matrix metalloproteinase 7 preproprotein [Homo sapiens]    225   7e-59
gi|58331148 matrix metalloproteinase 11 preproprotein [Homo sapi...   214   2e-55
gi|112382270 matrix metalloproteinase 17 preproprotein [Homo sap...   214   2e-55
gi|11968059 matrix metalloproteinase 25 preproprotein [Homo sapi...   206   5e-53
gi|149999365 matrix metalloproteinase 16 isoform 2 preproprotein...   204   2e-52
gi|4505213 matrix metalloproteinase 19 isoform rasi-1 preproprot...   203   3e-52
gi|73808266 matrix metalloproteinase 26 preproprotein [Homo sapi...   182   8e-46
gi|189217853 matrix metalloproteinase 2 isoform b [Homo sapiens]      174   2e-43
gi|11342666 matrix metalloproteinase 2 isoform a preproprotein [...   174   2e-43
gi|13236530 matrix metalloproteinase 28 isoform 1 preproprotein ...   153   4e-37
gi|74272287 matrix metalloproteinase 9 preproprotein [Homo sapiens]   140   4e-33
gi|22218341 matrix metalloproteinase 21 preproprotein [Homo sapi...   124   2e-28
gi|169203154 PREDICTED: similar to hCG2042634 [Homo sapiens]           87   5e-17
gi|5902004 matrix metalloproteinase 23B precursor [Homo sapiens]       87   5e-17
gi|239750339 PREDICTED: hypothetical protein XP_002347374 [Homo ...    82   1e-15
gi|169202084 PREDICTED: similar to hCG2042634 [Homo sapiens]           82   2e-15
gi|169203660 PREDICTED: similar to hCG2042634 [Homo sapiens]           80   6e-15

>gi|73808268 matrix metalloproteinase 27 [Homo sapiens]
          Length = 513

 Score = 1068 bits (2761), Expect = 0.0
 Identities = 513/513 (100%), Positives = 513/513 (100%)

Query: 1   MKRLLLLFLFFITFSSAFPLVRMTENEENMQLAQAYLNQFYSLEIEGNHLVQSKNRSLID 60
           MKRLLLLFLFFITFSSAFPLVRMTENEENMQLAQAYLNQFYSLEIEGNHLVQSKNRSLID
Sbjct: 1   MKRLLLLFLFFITFSSAFPLVRMTENEENMQLAQAYLNQFYSLEIEGNHLVQSKNRSLID 60

Query: 61  DKIREMQAFFGLTVTGKLDSNTLEIMKTPRCGVPDVGQYGYTLPGWRKYNLTYRIINYTP 120
           DKIREMQAFFGLTVTGKLDSNTLEIMKTPRCGVPDVGQYGYTLPGWRKYNLTYRIINYTP
Sbjct: 61  DKIREMQAFFGLTVTGKLDSNTLEIMKTPRCGVPDVGQYGYTLPGWRKYNLTYRIINYTP 120

Query: 121 DMARAAVDEAIQEGLEVWSKVTPLKFTKISKGIADIMIAFRTRVHGRCPRYFDGPLGVLG 180
           DMARAAVDEAIQEGLEVWSKVTPLKFTKISKGIADIMIAFRTRVHGRCPRYFDGPLGVLG
Sbjct: 121 DMARAAVDEAIQEGLEVWSKVTPLKFTKISKGIADIMIAFRTRVHGRCPRYFDGPLGVLG 180

Query: 181 HAFPPGPGLGGDTHFDEDENWTKDGAGFNLFLVAAHEFGHALGLSHSNDQTALMFPNYVS 240
           HAFPPGPGLGGDTHFDEDENWTKDGAGFNLFLVAAHEFGHALGLSHSNDQTALMFPNYVS
Sbjct: 181 HAFPPGPGLGGDTHFDEDENWTKDGAGFNLFLVAAHEFGHALGLSHSNDQTALMFPNYVS 240

Query: 241 LDPRKYPLSQDDINGIQSIYGGLPKEPAKPKEPTIPHACDPDLTFDAITTFRREVMFFKG 300
           LDPRKYPLSQDDINGIQSIYGGLPKEPAKPKEPTIPHACDPDLTFDAITTFRREVMFFKG
Sbjct: 241 LDPRKYPLSQDDINGIQSIYGGLPKEPAKPKEPTIPHACDPDLTFDAITTFRREVMFFKG 300

Query: 301 RHLWRIYYDITDVEFELIASFWPSLPADLQAAYENPRDKILVFKDENFWMIRGYAVLPDY 360
           RHLWRIYYDITDVEFELIASFWPSLPADLQAAYENPRDKILVFKDENFWMIRGYAVLPDY
Sbjct: 301 RHLWRIYYDITDVEFELIASFWPSLPADLQAAYENPRDKILVFKDENFWMIRGYAVLPDY 360

Query: 361 PKSIHTLGFPGRVKKIDAAVCDKTTRKTYFFVGIWCWRFDEMTQTMDKGFPQRVVKHFPG 420
           PKSIHTLGFPGRVKKIDAAVCDKTTRKTYFFVGIWCWRFDEMTQTMDKGFPQRVVKHFPG
Sbjct: 361 PKSIHTLGFPGRVKKIDAAVCDKTTRKTYFFVGIWCWRFDEMTQTMDKGFPQRVVKHFPG 420

Query: 421 ISIRVDAAFQYKGFFFFSRGSKQFEYDIKTKNITRIMRTNTWFQCKEPKNSSFGFDINKE 480
           ISIRVDAAFQYKGFFFFSRGSKQFEYDIKTKNITRIMRTNTWFQCKEPKNSSFGFDINKE
Sbjct: 421 ISIRVDAAFQYKGFFFFSRGSKQFEYDIKTKNITRIMRTNTWFQCKEPKNSSFGFDINKE 480

Query: 481 KAHSGGIKILYHKSLSLFIFGIVHLLKNTSIYQ 513
           KAHSGGIKILYHKSLSLFIFGIVHLLKNTSIYQ
Sbjct: 481 KAHSGGIKILYHKSLSLFIFGIVHLLKNTSIYQ 513


>gi|4505217 matrix metalloproteinase 3 preproprotein [Homo sapiens]
          Length = 477

 Score =  483 bits (1242), Expect = e-136
 Identities = 245/479 (51%), Positives = 314/479 (65%), Gaps = 16/479 (3%)

Query: 1   MKRLLLLFLFFITFSSAFPLVRMTENEE-NMQLAQAYLNQFYSLEIEGNHLVQSKNRSLI 59
           MK L +L L  +   SA+PL      E+ +M L Q YL  +Y L+ +    V+ K+   +
Sbjct: 1   MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPV 60

Query: 60  DDKIREMQAFFGLTVTGKLDSNTLEIMKTPRCGVPDVGQYGYTLPG---WRKYNLTYRII 116
             KIREMQ F GL VTGKLDS+TLE+M+ PRCGVPDVG +  T PG   WRK +LTYRI+
Sbjct: 61  VKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFR-TFPGIPKWRKTHLTYRIV 119

Query: 117 NYTPDMARAAVDEAIQEGLEVWSKVTPLKFTKISKGIADIMIAFRTRVHGRCPRYFDGPL 176
           NYTPD+ + AVD A+++ L+VW +VTPL F+++ +G ADIMI+F  R HG     FDGP 
Sbjct: 120 NYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYP-FDGPG 178

Query: 177 GVLGHAFPPGPGLGGDTHFDEDENWTKDGAGFNLFLVAAHEFGHALGLSHSNDQTALMFP 236
            VL HA+ PGPG+ GD HFD+DE WTKD  G NLFLVAAHE GH+LGL HS +  ALM+P
Sbjct: 179 NVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYP 238

Query: 237 NYVSL-DPRKYPLSQDDINGIQSIYGGLPKEPAKP--------KEPTIPHACDPDLTFDA 287
            Y SL D  ++ LSQDDINGIQS+YG  P  P  P         EP  P  CDP L+FDA
Sbjct: 239 LYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDA 298

Query: 288 ITTFRREVMFFKGRHLWRIYYDITDVEFELIASFWPSLPADLQAAYE-NPRDKILVFKDE 346
           ++T R E++ FK RH WR      + E  LI+SFWPSLP+ + AAYE   +D + +FK  
Sbjct: 299 VSTLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGN 358

Query: 347 NFWMIRGYAVLPDYPKSIHTLGFPGRVKKIDAAVCDKTTRKTYFFVGIWCWRFDEMTQTM 406
            FW IRG  V   YP+ IHTLGFP  V+KIDAA+ DK   KTYFFV    WRFDE   +M
Sbjct: 359 QFWAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSM 418

Query: 407 DKGFPQRVVKHFPGISIRVDAAFQYKGFFFFSRGSKQFEYDIKTKNITRIMRTNTWFQC 465
           + GFP+++ + FPGI  ++DA F+  GFF+F  GS Q E+D   K +T  +++N+W  C
Sbjct: 419 EPGFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC 477


>gi|4505205 matrix metalloproteinase 10 preproprotein [Homo sapiens]
          Length = 476

 Score =  476 bits (1226), Expect = e-134
 Identities = 244/478 (51%), Positives = 320/478 (66%), Gaps = 15/478 (3%)

Query: 1   MKRLLLLFLFFITFSSAFPLVRMTENEE-NMQLAQAYLNQFYSLEIEGNHLVQSKNRSLI 59
           M  L  L L  +   SA+PL    + E+ N  LAQ YL ++Y+LE +     + K+ +LI
Sbjct: 1   MMHLAFLVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKYYNLEKDVKQF-RRKDSNLI 59

Query: 60  DDKIREMQAFFGLTVTGKLDSNTLEIMKTPRCGVPDVGQYGYT--LPGWRKYNLTYRIIN 117
             KI+ MQ F GL VTGKLD++TLE+M+ PRCGVPDVG +     +P WRK +LTYRI+N
Sbjct: 60  VKKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYRIVN 119

Query: 118 YTPDMARAAVDEAIQEGLEVWSKVTPLKFTKISKGIADIMIAFRTRVHGRCPRYFDGPLG 177
           YTPD+ R AVD AI++ L+VW +VTPL F+++ +G ADIMI+F  + HG     FDGP  
Sbjct: 120 YTPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYS-FDGPGH 178

Query: 178 VLGHAFPPGPGLGGDTHFDEDENWTKDGAGFNLFLVAAHEFGHALGLSHSNDQTALMFPN 237
            L HA+PPGPGL GD HFD+DE WT+D +G NLFLVAAHE GH+LGL HS +  ALM+P 
Sbjct: 179 SLAHAYPPGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANTEALMYPL 238

Query: 238 YVSL-DPRKYPLSQDDINGIQSIYGGLPKEPAKPKEPT--------IPHACDPDLTFDAI 288
           Y S  +  ++ LSQDD+NGIQS+YG  P    +P  PT        +P  CDP L+FDAI
Sbjct: 239 YNSFTELAQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFDAI 298

Query: 289 TTFRREVMFFKGRHLWRIYYDITDVEFELIASFWPSLPADLQAAYE-NPRDKILVFKDEN 347
           +T R E +FFK R+ WR  +   + EF LI++FWPSLP+ L AAYE N RD + +FK   
Sbjct: 299 STLRGEYLFFKDRYFWRRSHWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNE 358

Query: 348 FWMIRGYAVLPDYPKSIHTLGFPGRVKKIDAAVCDKTTRKTYFFVGIWCWRFDEMTQTMD 407
           FW IRG  V   YP+ IHTLGFP  ++KIDAAV DK  +KTYFF     WRFDE +Q+M+
Sbjct: 359 FWAIRGNEVQAGYPRGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSME 418

Query: 408 KGFPQRVVKHFPGISIRVDAAFQYKGFFFFSRGSKQFEYDIKTKNITRIMRTNTWFQC 465
           +GFP+ +   FPG+  +VDA  Q  GFF+F  GS QFE+D   + +T I+++N+W  C
Sbjct: 419 QGFPRLIADDFPGVEPKVDAVLQAFGFFYFFSGSSQFEFDPNARMVTHILKSNSWLHC 476


>gi|4505215 matrix metalloproteinase 1 isoform 1 preproprotein [Homo
           sapiens]
          Length = 469

 Score =  450 bits (1157), Expect = e-126
 Identities = 233/467 (49%), Positives = 309/467 (66%), Gaps = 9/467 (1%)

Query: 5   LLLFLFFITFSSAFPLVRMTENEENMQLAQAYLNQFYSLEIEGNHLVQSKNRSLIDDKIR 64
           LLL LF+   S +FP    T+ E+++ L Q YL ++Y+L+ +G  + + +N   + +K++
Sbjct: 7   LLLLLFWGVVSHSFPATLETQ-EQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLK 65

Query: 65  EMQAFFGLTVTGKLDSNTLEIMKTPRCGVPDVGQYGYTL--PGWRKYNLTYRIINYTPDM 122
           +MQ FFGL VTGK D+ TL++MK PRCGVPDV Q+  T   P W + +LTYRI NYTPD+
Sbjct: 66  QMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDL 125

Query: 123 ARAAVDEAIQEGLEVWSKVTPLKFTKISKGIADIMIAFRTRVHGRCPRYFDGPLGVLGHA 182
            RA VD AI++  ++WS VTPL FTK+S+G ADIMI+F    H R    FDGP G L HA
Sbjct: 126 PRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDH-RDNSPFDGPGGNLAHA 184

Query: 183 FPPGPGLGGDTHFDEDENWTKDGAGFNLFLVAAHEFGHALGLSHSNDQTALMFPNYVSLD 242
           F PGPG+GGD HFDEDE WT +   +NL  VAAHE GH+LGLSHS D  ALM+P+Y    
Sbjct: 185 FQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSG 244

Query: 243 PRKYPLSQDDINGIQSIYGGLPKEPAKPKEPTIPHACDPDLTFDAITTFRREVMFFKGRH 302
             +  L+QDDI+GIQ+IYG   + P +P  P  P ACD  LTFDAITT R EVMFFK R 
Sbjct: 245 DVQ--LAQDDIDGIQAIYGR-SQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRF 301

Query: 303 LWRIYYDITDVEFELIASFWPSLPADLQAAYE-NPRDKILVFKDENFWMIRGYAVLPDYP 361
             R      +VE   I+ FWP LP  L+AAYE   RD++  FK   +W ++G  VL  YP
Sbjct: 302 YMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYP 361

Query: 362 KSIHT-LGFPGRVKKIDAAVCDKTTRKTYFFVGIWCWRFDEMTQTMDKGFPQRVVKHFPG 420
           K I++  GFP  VK IDAA+ ++ T KTYFFV    WR+DE  ++MD G+P+ +   FPG
Sbjct: 362 KDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPG 421

Query: 421 ISIRVDAAFQYKGFFFFSRGSKQFEYDIKTKNITRIMRTNTWFQCKE 467
           I  +VDA F   GFF+F  G++Q+++D KTK I  + + N+WF C++
Sbjct: 422 IGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRK 468


>gi|4505221 matrix metalloproteinase 8 preproprotein [Homo sapiens]
          Length = 467

 Score =  449 bits (1156), Expect = e-126
 Identities = 228/470 (48%), Positives = 298/470 (63%), Gaps = 12/470 (2%)

Query: 1   MKRLLLLFLFFITFSSAFPLVRMTENEENMQLAQAYLNQFYSLEIEGNHLVQSKNRSLID 60
           +K L  L L  +  S AFP+   +  E+N +  Q YL +FY L        +    ++I 
Sbjct: 4   LKTLPFLLLLHVQISKAFPV---SSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIV 60

Query: 61  DKIREMQAFFGLTVTGKLDSNTLEIMKTPRCGVPDVGQYGYTL--PGWRKYNLTYRIINY 118
           +K++EMQ FFGL VTGK +  TL++MK PRCGVPD G +  T   P W + NLTYRI NY
Sbjct: 61  EKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNY 120

Query: 119 TPDMARAAVDEAIQEGLEVWSKVTPLKFTKISKGIADIMIAFRTRVHG-RCPRYFDGPLG 177
           TP ++ A V+ AI++  E+WS  +PL FT+IS+G ADI IAF  R HG   P  FDGP G
Sbjct: 121 TPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSP--FDGPNG 178

Query: 178 VLGHAFPPGPGLGGDTHFDEDENWTKDGAGFNLFLVAAHEFGHALGLSHSNDQTALMFPN 237
           +L HAF PG G+GGD HFD +E WT   A +NLFLVAAHEFGH+LGL+HS+D  ALM+PN
Sbjct: 179 ILAHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPN 238

Query: 238 YVSLDPRKYPLSQDDINGIQSIYGGLPKEPAKPKEPTIPHACDPDLTFDAITTFRREVMF 297
           Y   +   Y L QDDI+GIQ+IY GL   P +P  P+ P  CDP LTFDAITT R E++F
Sbjct: 239 YAFRETSNYSLPQDDIDGIQAIY-GLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILF 297

Query: 298 FKGRHLWRIYYDITDVEFELIASFWPSLPADLQAAYEN-PRDKILVFKDENFWMIRGYAV 356
           FK R+ WR +  +  VE   I+ FWPSLP  +QAAYE+  RD I +FK   +W + GY +
Sbjct: 298 FKDRYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDI 357

Query: 357 LPDYPKSIHTLGFPGRVKKIDAAVCDKTTRKTYFFVGIWCWRFDEMTQTMDKGFPQRVVK 416
           L  YPK I   GFP  V+ IDAAV  ++  KTYFFV    WR+D   Q M+ G+P+ +  
Sbjct: 358 LQGYPKDISNYGFPSSVQAIDAAVFYRS--KTYFFVNDQFWRYDNQRQFMEPGYPKSISG 415

Query: 417 HFPGISIRVDAAFQYKGFFFFSRGSKQFEYDIKTKNITRIMRTNTWFQCK 466
            FPGI  +VDA FQ + FF    G + + +D+  + +TR+ R N W  C+
Sbjct: 416 AFPGIESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCR 465


>gi|4505209 matrix metalloproteinase 13 preproprotein [Homo sapiens]
          Length = 471

 Score =  441 bits (1133), Expect = e-123
 Identities = 229/472 (48%), Positives = 293/472 (62%), Gaps = 15/472 (3%)

Query: 4   LLLLFLFFI-TFSSAFPLVRMTE----NEENMQLAQAYLNQFYS-LEIEGNHLVQSKNRS 57
           +L  FLF   T   A PL    +    +EE++Q A+ YL  +Y    + G  +++    S
Sbjct: 5   VLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYHPTNLAG--ILKENAAS 62

Query: 58  LIDDKIREMQAFFGLTVTGKLDSNTLEIMKTPRCGVPDVGQYGY---TLPGWRKYNLTYR 114
            + +++REMQ+FFGL VTGKLD NTL++MK PRCGVPDVG+Y     TL  W K NLTYR
Sbjct: 63  SMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLK-WSKMNLTYR 121

Query: 115 IINYTPDMARAAVDEAIQEGLEVWSKVTPLKFTKISKGIADIMIAFRTRVHGRCPRYFDG 174
           I+NYTPDM  + V++A ++  +VWS VTPL FT++  GIADIMI+F  + HG     FDG
Sbjct: 122 IVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYP-FDG 180

Query: 175 PLGVLGHAFPPGPGLGGDTHFDEDENWTKDGAGFNLFLVAAHEFGHALGLSHSNDQTALM 234
           P G+L HAFPPGP  GGD HFD+DE WT    G+NLFLVAAHEFGH+LGL HS D  ALM
Sbjct: 181 PSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALM 240

Query: 235 FPNYVSLDPRKYPLSQDDINGIQSIYGGLPKEPAKPKEPTIPHACDPDLTFDAITTFRRE 294
           FP Y       + L  DD+ GIQS+YG   ++P  PK P  P  CDP L+ DAIT+ R E
Sbjct: 241 FPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDP-NPKHPKTPDKCDPSLSLDAITSLRGE 299

Query: 295 VMFFKGRHLWRIYYDITDVEFELIASFWPSLPADLQAAYENP-RDKILVFKDENFWMIRG 353
            M FK R  WR++    D E  L  SFWP LP  + AAYE+P  D I +F+   FW + G
Sbjct: 300 TMIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNG 359

Query: 354 YAVLPDYPKSIHTLGFPGRVKKIDAAVCDKTTRKTYFFVGIWCWRFDEMTQTMDKGFPQR 413
           Y +L  YPK I  LG P  VKKI AAV  + T KT  F G   WR+D+    MDK +P+ 
Sbjct: 360 YDILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRL 419

Query: 414 VVKHFPGISIRVDAAFQYKGFFFFSRGSKQFEYDIKTKNITRIMRTNTWFQC 465
           + + FPGI  +VDA ++  G+ +F  G  QFEY I +  I R+M  N+   C
Sbjct: 420 IEEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSILWC 471


>gi|73858572 matrix metalloproteinase 12 preproprotein [Homo
           sapiens]
          Length = 470

 Score =  439 bits (1130), Expect = e-123
 Identities = 229/472 (48%), Positives = 306/472 (64%), Gaps = 12/472 (2%)

Query: 3   RLLLLFLFFITFSSAFPLVRMTENEENMQL-AQAYLNQFYSLEIEGNHLVQSK-NRSLID 60
           + LL+ L   T S A PL   T  E+N  L  + YL +FY LEI    + + K + +L+ 
Sbjct: 2   KFLLILLLQATASGALPLNSSTSLEKNNVLFGERYLEKFYGLEINKLPVTKMKYSGNLMK 61

Query: 61  DKIREMQAFFGLTVTGKLDSNTLEIMKTPRCGVPDVGQYGYTLPG---WRKYNLTYRIIN 117
           +KI+EMQ F GL VTG+LD++TLE+M  PRCGVPDV  +   +PG   WRK+ +TYRI N
Sbjct: 62  EKIQEMQHFLGLKVTGQLDTSTLEMMHAPRCGVPDVHHFR-EMPGGPVWRKHYITYRINN 120

Query: 118 YTPDMARAAVDEAIQEGLEVWSKVTPLKFTKISKGIADIMIAFRTRVHGRCPRYFDGPLG 177
           YTPDM R  VD AI++  +VWS VTPLKF+KI+ G+ADI++ F    HG     FDG  G
Sbjct: 121 YTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDF-HAFDGKGG 179

Query: 178 VLGHAFPPGPGLGGDTHFDEDENWTKDGAGFNLFLVAAHEFGHALGLSHSNDQTALMFPN 237
           +L HAF PG G+GGD HFDEDE WT    G NLFL A HE GH+LGL HS+D  A+MFP 
Sbjct: 180 ILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPT 239

Query: 238 YVSLDPRKYPLSQDDINGIQSIYGGLPKEPAKPKEP--TIPHACDPDLTFDAITTFRREV 295
           Y  +D   + LS DDI GIQS+YG  PKE  +   P  + P  CDP+L+FDA+TT   ++
Sbjct: 240 YKYVDINTFRLSADDIRGIQSLYGD-PKENQRLPNPDNSEPALCDPNLSFDAVTTVGNKI 298

Query: 296 MFFKGRHLWRIYYDITDVEFELIASFWPSLPADLQAAYE-NPRDKILVFKDENFWMIRGY 354
            FFK R  W    +       LI+S WP+LP+ ++AAYE   R+++ +FKD+ +W+I   
Sbjct: 299 FFFKDRFFWLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEARNQVFLFKDDKYWLISNL 358

Query: 355 AVLPDYPKSIHTLGFPGRVKKIDAAVCDKTTRKTYFFVGIWCWRFDEMTQTMDKGFPQRV 414
              P+YPKSIH+ GFP  VKKIDAAV +    +TYFFV    WR+DE  Q MD G+P+ +
Sbjct: 359 RPEPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMDPGYPKLI 418

Query: 415 VKHFPGISIRVDAAFQYKG-FFFFSRGSKQFEYDIKTKNITRIMRTNTWFQC 465
            K+F GI  ++DA F  K  +++F +GS QFEYD   + IT+ +++N+WF C
Sbjct: 419 TKNFQGIGPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITKTLKSNSWFGC 470


>gi|225543094 matrix metalloproteinase 1 isoform 2 [Homo sapiens]
          Length = 403

 Score =  415 bits (1066), Expect = e-116
 Identities = 214/406 (52%), Positives = 271/406 (66%), Gaps = 8/406 (1%)

Query: 66  MQAFFGLTVTGKLDSNTLEIMKTPRCGVPDVGQYGYTL--PGWRKYNLTYRIINYTPDMA 123
           MQ FFGL VTGK D+ TL++MK PRCGVPDV Q+  T   P W + +LTYRI NYTPD+ 
Sbjct: 1   MQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLP 60

Query: 124 RAAVDEAIQEGLEVWSKVTPLKFTKISKGIADIMIAFRTRVHGRCPRYFDGPLGVLGHAF 183
           RA VD AI++  ++WS VTPL FTK+S+G ADIMI+F    H R    FDGP G L HAF
Sbjct: 61  RADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDH-RDNSPFDGPGGNLAHAF 119

Query: 184 PPGPGLGGDTHFDEDENWTKDGAGFNLFLVAAHEFGHALGLSHSNDQTALMFPNYVSLDP 243
            PGPG+GGD HFDEDE WT +   +NL  VAAHE GH+LGLSHS D  ALM+P+Y     
Sbjct: 120 QPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGD 179

Query: 244 RKYPLSQDDINGIQSIYGGLPKEPAKPKEPTIPHACDPDLTFDAITTFRREVMFFKGRHL 303
            +  L+QDDI+GIQ+IYG   + P +P  P  P ACD  LTFDAITT R EVMFFK R  
Sbjct: 180 VQ--LAQDDIDGIQAIYGR-SQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFY 236

Query: 304 WRIYYDITDVEFELIASFWPSLPADLQAAYE-NPRDKILVFKDENFWMIRGYAVLPDYPK 362
            R      +VE   I+ FWP LP  L+AAYE   RD++  FK   +W ++G  VL  YPK
Sbjct: 237 MRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPK 296

Query: 363 SIHT-LGFPGRVKKIDAAVCDKTTRKTYFFVGIWCWRFDEMTQTMDKGFPQRVVKHFPGI 421
            I++  GFP  VK IDAA+ ++ T KTYFFV    WR+DE  ++MD G+P+ +   FPGI
Sbjct: 297 DIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGI 356

Query: 422 SIRVDAAFQYKGFFFFSRGSKQFEYDIKTKNITRIMRTNTWFQCKE 467
             +VDA F   GFF+F  G++Q+++D KTK I  + + N+WF C++
Sbjct: 357 GHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRK 402


>gi|45359865 matrix metalloproteinase 20 preproprotein [Homo
           sapiens]
          Length = 483

 Score =  371 bits (953), Expect = e-103
 Identities = 200/478 (41%), Positives = 292/478 (61%), Gaps = 19/478 (3%)

Query: 4   LLLLFLFFITFSSAFP-LVRMTEN--EENMQLAQAYLNQFYSLEIEGNHLVQ--SKNRSL 58
           L +  +  + FS+A P LV  +      N +LAQAYL+++Y+ + EG+ + +  ++  + 
Sbjct: 9   LAVFLIMALKFSTAAPSLVAASPRTWRNNYRLAQAYLDKYYTNK-EGHQIGEMVARGSNS 67

Query: 59  IDDKIREMQAFFGLTVTGKLDSNTLEIMKTPRCGVPDVGQYGYTL--PGWRKYNLTYRII 116
           +  KI+E+QAFFGL VTGKLD  T+ ++K PRCGVPDV  Y      P W+K  LTYRI 
Sbjct: 68  MIRKIKELQAFFGLQVTGKLDQTTMNVIKKPRCGVPDVANYRLFPGEPKWKKNTLTYRIS 127

Query: 117 NYTPDMARAAVDEAIQEGLEVWSKVTPLKFTKISKGIADIMIAFRTRVHGRCPRYFDGPL 176
            YTP M+   VD+A++  L+ WS   PL F +I+ G ADIMI+F    HG     FDGP 
Sbjct: 128 KYTPSMSSVEVDKAVEMALQAWSSAVPLSFVRINSGEADIMISFENGDHGDSYP-FDGPR 186

Query: 177 GVLGHAFPPGPGLGGDTHFDEDENWTKDGAGFNLFLVAAHEFGHALGLSHSNDQTALMFP 236
           G L HAF PG GLGGDTHFD  E WT    GFNLF VAAHEFGHALGL+HS D +ALM+P
Sbjct: 187 GTLAHAFAPGEGLGGDTHFDNAEKWTMGTNGFNLFTVAAHEFGHALGLAHSTDPSALMYP 246

Query: 237 NYVSLDPRKYPLSQDDINGIQSIYG------GLPKEPAKP-KEPTIPHACDPDLTFDAIT 289
            Y   +P  + L +DD+ GIQ++YG      G P  P  P  +P+IP  CD   +FDA+T
Sbjct: 247 TYKYKNPYGFHLPKDDVKGIQALYGPRKVFLGKPTLPHAPHHKPSIPDLCDSSSSFDAVT 306

Query: 290 TFRREVMFFKGRHLWRIYYDI-TDVEFELIASFWPSLPADLQAAYE-NPRDKILVFKDEN 347
              +E++ FK R  WR    + T +    I S +P L +++ AAYE   R     FK  +
Sbjct: 307 MLGKELLLFKDRIFWRRQVHLRTGIRPSTITSSFPQLMSNVDAAYEVAERGTAYFFKGPH 366

Query: 348 FWMIRGYAVLPDYPKSIHTLGFPGRVKKIDAAVCDKTTRKTYFFVGIWCWRFDEMTQTMD 407
           +W+ RG+  +   P++I+  GFP  V++IDAAV  +  +KT FFVG   + +DE  + M+
Sbjct: 367 YWITRGFQ-MQGPPRTIYDFGFPRHVQQIDAAVYLREPQKTLFFVGDEYYSYDERKRKME 425

Query: 408 KGFPQRVVKHFPGISIRVDAAFQYKGFFFFSRGSKQFEYDIKTKNITRIMRTNTWFQC 465
           K +P+   + F G++ ++DAA +  G+ +F  G K ++YD + +++  ++++++W  C
Sbjct: 426 KDYPKNTEEEFSGVNGQIDAAVELNGYIYFFSGPKTYKYDTEKEDVVSVVKSSSWIGC 483


>gi|5729929 matrix metalloproteinase 24 preproprotein [Homo sapiens]
          Length = 645

 Score =  266 bits (681), Expect = 3e-71
 Identities = 165/447 (36%), Positives = 227/447 (50%), Gaps = 63/447 (14%)

Query: 59  IDDKIREMQAFFGLTVTGKLDSNTLEIMKTPRCGVPDVG---------QYGYTLPGWRKY 109
           +   +  MQ F+G+ VTG LD  T+E MK PRCGVPD           +Y  T   WR+ 
Sbjct: 107 LQSAVSTMQQFYGIPVTGVLDQTTIEWMKKPRCGVPDHPHLSRRRRNKRYALTGQKWRQK 166

Query: 110 NLTYRIINYTPDMARAAVDEAIQEGLEVWSKVTPLKFTKI-------SKGIADIMIAFRT 162
           ++TY I NYTP +      +AI++  +VW KVTPL F ++        +  ADIMI F +
Sbjct: 167 HITYSIHNYTPKVGELDTRKAIRQAFDVWQKVTPLTFEEVPYHEIKSDRKEADIMIFFAS 226

Query: 163 RVHGRCPRYFDGPLGVLGHAFPPGPGLGGDTHFDEDENWTKDGA---GFNLFLVAAHEFG 219
             HG     FDG  G L HA+ PGPG+GGDTHFD DE WT   A   G +LFLVA HE G
Sbjct: 227 GFHGDSSP-FDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNANHDGNDLFLVAVHELG 285

Query: 220 HALGLSHSNDQTALMFPNYVSLDPRKYPLSQDDINGIQSIYGGLPKEPAKPKEP------ 273
           HALGL HS+D +A+M P Y  ++   + L QDD+ GIQ IYG  P EP +P  P      
Sbjct: 286 HALGLEHSSDPSAIMAPFYQYMETHNFKLPQDDLQGIQKIYGP-PAEPLEPTRPLPTLPV 344

Query: 274 ------------------------------TIPHACDPDLTFDAITTFRREVMFFKGRHL 303
                                         T P+ CD +  F+ +  FR E+  FK R  
Sbjct: 345 RRIHSPSERKHERQPRPPRPPLGDRPSTPGTKPNICDGN--FNTVALFRGEMFVFKDRWF 402

Query: 304 WRIYYDITDVEFEL-IASFWPSLPADLQAAYENPRDKILVFKDENFWMIRGYAVLPDYPK 362
           WR+  +     + + I  FW  LPA + AAYE    + + FK + +W+ +   V P YP 
Sbjct: 403 WRLRNNRVQEGYPMQIEQFWKGLPARIDAAYERADGRFVFFKGDKYWVFKEVTVEPGYPH 462

Query: 363 SIHTLGFPGRVKKIDAAVCDKTTRKTYFFVGIWCWRFDEMTQTMDKGFPQRVVKHFPGIS 422
           S+  LG     + ID A+  +   KTYFF G   WR+ E  +  D G+P+ +   + GI 
Sbjct: 463 SLGELGSCLPREGIDTALRWEPVGKTYFFKGERYWRYSEERRATDPGYPKPITV-WKGIP 521

Query: 423 IRVDAAFQYK-GFF-FFSRGSKQFEYD 447
                AF  K G++ +F +G   +++D
Sbjct: 522 QAPQGAFISKEGYYTYFYKGRDYWKFD 548


>gi|4505211 matrix metalloproteinase 15 preproprotein [Homo sapiens]
          Length = 669

 Score =  261 bits (667), Expect = 1e-69
 Identities = 170/492 (34%), Positives = 235/492 (47%), Gaps = 83/492 (16%)

Query: 33  AQAYLNQFYSLEIEGNHLVQSKNRSLIDDKIREMQAFFGLTVTGKLDSNTLEIMKTPRCG 92
           A+ +L  +  L     H+   ++  ++   + EMQ F+G+ VTG LD  T E MK PRCG
Sbjct: 53  AENWLRLYGYLPQPSRHMSTMRSAQILASALAEMQRFYGIPVTGVLDEETKEWMKRPRCG 112

Query: 93  VPDVGQYG-------------YTLPG--WRKYNLTYRIINYTPDMARAAVDEAIQEGLEV 137
           VPD  Q+G             Y L G  W  ++LT+ I NYT  +      EA++    V
Sbjct: 113 VPD--QFGVRVKANLRRRRKRYALTGRKWNNHHLTFSIQNYTEKLGWYHSMEAVRRAFRV 170

Query: 138 WSKVTPLKFTKIS--------KGIADIMIAFRTRVHGRCPRYFDGPLGVLGHAFPPGPGL 189
           W + TPL F ++         +  ADIM+ F +  HG     FDG  G L HA+ PGPGL
Sbjct: 171 WEQATPLVFQEVPYEDIRLRRQKEADIMVLFASGFHGDSSP-FDGTGGFLAHAYFPGPGL 229

Query: 190 GGDTHFDEDENWT---KDGAGFNLFLVAAHEFGHALGLSHSNDQTALMFPNYVSLDPRKY 246
           GGDTHFD DE WT    D  G NLFLVA HE GHALGL HS++  A+M P Y   D   +
Sbjct: 230 GGDTHFDADEPWTFSSTDLHGNNLFLVAVHELGHALGLEHSSNPNAIMAPFYQWKDVDNF 289

Query: 247 PLSQDDINGIQSIY-------------------------------------GGLPKEPAK 269
            L +DD+ GIQ +Y                                     GG P+ P K
Sbjct: 290 KLPEDDLRGIQQLYGTPDGQPQPTQPLPTVTPRRPGRPDHRPPRPPQPPPPGGKPERPPK 349

Query: 270 PKEPTIPHA-----------CDPDLTFDAITTFRREVMFFKGRHLWRIYYD-ITDVEFEL 317
           P  P  P A           CD D  FD +   R E+  FKGR  WR+ ++ + D     
Sbjct: 350 PGPPVQPRATERPDQYGPNICDGD--FDTVAMLRGEMFVFKGRWFWRVRHNRVLDNYPMP 407

Query: 318 IASFWPSLPADLQAAYENPRDKILVFKDENFWMIRGYAVLPDYPKSIHTLGFPGRVKKID 377
           I  FW  LP D+ AAYE    + + FK + +W+ R   + P YP+ + + G      +ID
Sbjct: 408 IGHFWRGLPGDISAAYERQDGRFVFFKGDRYWLFREANLEPGYPQPLTSYGLGIPYDRID 467

Query: 378 AAVCDKTTRKTYFFVGIWCWRFDEMTQTMDKGFPQRVVKHFPGISIRVDAAF--QYKGFF 435
            A+  + T  T+FF     WRF+E TQ  D G+P + +  + GI      AF      + 
Sbjct: 468 TAIWWEPTGHTFFFQEDRYWRFNEETQRGDPGYP-KPISVWQGIPASPKGAFLSNDAAYT 526

Query: 436 FFSRGSKQFEYD 447
           +F +G+K +++D
Sbjct: 527 YFYKGTKYWKFD 538


>gi|4826834 matrix metalloproteinase 14 preproprotein [Homo sapiens]
          Length = 582

 Score =  260 bits (664), Expect = 2e-69
 Identities = 167/456 (36%), Positives = 231/456 (50%), Gaps = 46/456 (10%)

Query: 34  QAYLNQFYSLEIEGNHLVQSKNRSLIDDKIREMQAFFGLTVTGKLDSNTLEIMKTPRCGV 93
           +A+L Q+  L          ++   +   I  MQ F+GL VTGK D++T++ M+ PRCGV
Sbjct: 36  EAWLQQYGYLPPGDLRTHTQRSPQSLSAAIAAMQKFYGLQVTGKADADTMKAMRRPRCGV 95

Query: 94  PD---------VGQYGYTLPG--WRKYNLTYRIINYTPDMARAAVDEAIQEGLEVWSKVT 142
           PD         V +  Y + G  W+   +T+ I NYTP +   A  EAI++   VW   T
Sbjct: 96  PDKFGAEIKANVRRKRYAIQGLKWQHNEITFCIQNYTPKVGEYATYEAIRKAFRVWESAT 155

Query: 143 PLKFTKISKGI--------ADIMIAFRTRVHGRCPRYFDGPLGVLGHAFPPGPGLGGDTH 194
           PL+F ++            ADIMI F    HG     FDG  G L HA+ PGP +GGDTH
Sbjct: 156 PLRFREVPYAYIREGHEKQADIMIFFAEGFHGDSTP-FDGEGGFLAHAYFPGPNIGGDTH 214

Query: 195 FDEDENWT---KDGAGFNLFLVAAHEFGHALGLSHSNDQTALMFPNYVSLDPRKYPLSQD 251
           FD  E WT   +D  G ++FLVA HE GHALGL HS+D +A+M P Y  +D   + L  D
Sbjct: 215 FDSAEPWTVRNEDLNGNDIFLVAVHELGHALGLEHSSDPSAIMAPFYQWMDTENFVLPDD 274

Query: 252 DINGIQSIYGG----------------LPKEPAKPKEPTI-PHACDPDLTFDAITTFRRE 294
           D  GIQ +YGG                 P  P KPK PT  P+ CD +  FD +   R E
Sbjct: 275 DRRGIQQLYGGESGFPTKMPPQPRTTSRPSVPDKPKNPTYGPNICDGN--FDTVAMLRGE 332

Query: 295 VMFFKGRHLWRIYYD-ITDVEFELIASFWPSLPADLQAAYENPRDKILVFKDENFWMIRG 353
           +  FK R  WR+  + + D     I  FW  LPA +  AYE    K + FK +  W+   
Sbjct: 333 MFVFKERWFWRVRNNQVMDGYPMPIGQFWRGLPASINTAYERKDGKFVFFKGDKHWVFDE 392

Query: 354 YAVLPDYPKSIHTLGFPGRVKKIDAAVCDKTTRKTYFFVGIWCWRFDEMTQTMDKGFPQR 413
            ++ P YPK I  LG      KIDAA+      KTYFF G   +RF+E  + +D  +P+ 
Sbjct: 393 ASLEPGYPKHIKELGRGLPTDKIDAALFWMPNGKTYFFRGNKYYRFNEELRAVDSEYPKN 452

Query: 414 VVKHFPGISIRVDAAFQYKG--FFFFSRGSKQFEYD 447
            +K + GI      +F      F +F +G+K ++++
Sbjct: 453 -IKVWEGIPESPRGSFMGSDEVFTYFYKGNKYWKFN 487


>gi|13027802 matrix metalloproteinase 16 isoform 1 preproprotein
           [Homo sapiens]
          Length = 607

 Score =  259 bits (661), Expect = 5e-69
 Identities = 160/452 (35%), Positives = 224/452 (49%), Gaps = 62/452 (13%)

Query: 54  KNRSLIDDKIREMQAFFGLTVTGKLDSNTLEIMKTPRCGVPD---------VGQYGYTLP 104
           ++   +   +  MQ F+G+ +TGK+D NT++ MK PRCGVPD         + +  Y L 
Sbjct: 64  RSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALT 123

Query: 105 G--WRKYNLTYRIINYTPDMARAAVDEAIQEGLEVWSKVTPLKFTKI-------SKGIAD 155
           G  W+  ++TY I N TP +      +AI+   +VW  VTPL F ++        K   D
Sbjct: 124 GQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVD 183

Query: 156 IMIAFRTRVHGRCPRYFDGPLGVLGHAFPPGPGLGGDTHFDEDENWTKDGA---GFNLFL 212
           I I F +  HG     FDG  G L HA+ PGPG+GGDTHFD DE WT       G +LFL
Sbjct: 184 ITIIFASGFHGDSSP-FDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFL 242

Query: 213 VAAHEFGHALGLSHSNDQTALMFPNYVSLDPRKYPLSQDDINGIQSIYGGLPK------- 265
           VA HE GHALGL HSND TA+M P Y  ++   + L  DD+ GIQ IYG   K       
Sbjct: 243 VAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRP 302

Query: 266 -------------------EPAKPKEPT--------IPHACDPDLTFDAITTFRREVMFF 298
                               P  P+ PT         P+ CD +  F+ +   RRE+  F
Sbjct: 303 LPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGN--FNTLAILRREMFVF 360

Query: 299 KGRHLWRIYYD-ITDVEFELIASFWPSLPADLQAAYENPRDKILVFKDENFWMIRGYAVL 357
           K +  WR+  + + D     I  FW  LP  + A YEN     + FK   +W+ +   + 
Sbjct: 361 KDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQ 420

Query: 358 PDYPKSIHTLGFPGRVKKIDAAVCDKTTRKTYFFVGIWCWRFDEMTQTMDKGFPQRVVKH 417
           P YP  + TLG       ID+A+  +   KTYFF G   WR+ E  +TMD G+P+ +   
Sbjct: 421 PGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITV- 479

Query: 418 FPGISIRVDAAFQYK--GFFFFSRGSKQFEYD 447
           + GI      AF +K  GF +F +G + ++++
Sbjct: 480 WKGIPESPQGAFVHKENGFTYFYKGKEYWKFN 511


>gi|4505219 matrix metalloproteinase 7 preproprotein [Homo sapiens]
          Length = 267

 Score =  225 bits (574), Expect = 7e-59
 Identities = 121/267 (45%), Positives = 158/267 (59%), Gaps = 14/267 (5%)

Query: 1   MKRLLLLFLFFITFSSAFPLVRMTENEENMQLAQA--YLNQFYSLEIEGNHLVQSKNRSL 58
           M+  +L  +  +  S A PL +       +Q  QA  YL +FY  + E      +KN + 
Sbjct: 1   MRLTVLCAVCLLPGSLALPLPQEAGGMSELQWEQAQDYLKRFYLYDSE------TKNANS 54

Query: 59  IDDKIREMQAFFGLTVTGKLDSNTLEIMKTPRCGVPDVGQYGY--TLPGWRKYNLTYRII 116
           ++ K++EMQ FFGL +TG L+S  +EIM+ PRCGVPDV +Y      P W    +TYRI+
Sbjct: 55  LEAKLKEMQKFFGLPITGMLNSRVIEIMQKPRCGVPDVAEYSLFPNSPKWTSKVVTYRIV 114

Query: 117 NYTPDMARAAVDEAIQEGLEVWSKVTPLKFTKISKGIADIMIAFRTRVHGRCPRYFDGPL 176
           +YT D+    VD  + + L +W K  PL F K+  G ADIMI F    HG     FDGP 
Sbjct: 115 SYTRDLPHITVDRLVSKALNMWGKEIPLHFRKVVWGTADIMIGFARGAHGDSYP-FDGPG 173

Query: 177 GVLGHAFPPGPGLGGDTHFDEDENWTKDGA--GFNLFLVAAHEFGHALGLSHSNDQTALM 234
             L HAF PG GLGGD HFDEDE WT DG+  G N    A HE GH+LG+ HS+D  A+M
Sbjct: 174 NTLAHAFAPGTGLGGDAHFDEDERWT-DGSSLGINFLYAATHELGHSLGMGHSSDPNAVM 232

Query: 235 FPNYVSLDPRKYPLSQDDINGIQSIYG 261
           +P Y + DP+ + LSQDDI GIQ +YG
Sbjct: 233 YPTYGNGDPQNFKLSQDDIKGIQKLYG 259


>gi|58331148 matrix metalloproteinase 11 preproprotein [Homo
           sapiens]
          Length = 488

 Score =  214 bits (545), Expect = 2e-55
 Identities = 153/422 (36%), Positives = 208/422 (49%), Gaps = 46/422 (10%)

Query: 86  MKTPRCGVPDVG--------QYGYTLPG--WRKYNLTYRIINYTPDMARAAVDEAIQEGL 135
           ++ PRCGVPD          Q  + L G  W K +LTYRI+ +   + +  V + + E L
Sbjct: 75  LRPPRCGVPDPSDGLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEAL 134

Query: 136 EVWSKVTPLKFTKISKGIADIMIAFRTRVHGRCPRYFDGPLGVLGHAFPPGPGLGGDTHF 195
           +VWS VTPL FT++ +G ADIMI F    HG     FDGP G+L HAF P     GD HF
Sbjct: 135 KVWSDVTPLTFTEVHEGRADIMIDFARYWHGD-DLPFDGPGGILAHAFFPKTHREGDVHF 193

Query: 196 DEDENWT-KDGAGFNLFLVAAHEFGHALGLSHSNDQTALMFPNYVSLDPRKYP--LSQDD 252
           D DE WT  D  G +L  VAAHEFGH LGL H+    ALM   Y      +YP  LS DD
Sbjct: 194 DYDETWTIGDDQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTF----RYPLSLSPDD 249

Query: 253 INGIQSIYG-----------------GLPKEPAKPKEPTI-PHACDPDLTFDAITTFRRE 294
             G+Q +YG                 G+      P EP   P AC  + +FDA++T R E
Sbjct: 250 CRGVQHLYGQPWPTVTSRTPALGPQAGIDTNEIAPLEPDAPPDAC--EASFDAVSTIRGE 307

Query: 295 VMFFKGRHLWRIYYDITDVEFELIAS-FWPSLPADLQAAYENPRDKILVFKDENFWMIRG 353
           + FFK   +WR+        +  +AS  W  LP+ + AA+E+ +  I  F+   +W+  G
Sbjct: 308 LFFFKAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAAFEDAQGHIWFFQGAQYWVYDG 367

Query: 354 YAVLPDYPKSIHTLGFPGRVKKIDAAVCDKTTRKTYFFVGIWCWRFDEMTQTMDKGFPQR 413
              +   P  +  LG   R     A V      K YFF G   WRF   T+ +D   P+R
Sbjct: 368 EKPVLG-PAPLTELGLV-RFPVHAALVWGPEKNKIYFFRGRDYWRFHPSTRRVDSPVPRR 425

Query: 414 VVKHFPGISIRVDAAFQ-YKGFFFFSRGSKQFEYD-IKTKNITRIMRT--NTWFQCKEPK 469
               + G+   +DAAFQ   G+ +F RG   +++D +K K +    R     +F C EP 
Sbjct: 426 AT-DWRGVPSEIDAAFQDADGYAYFLRGRLYWKFDPVKVKALEGFPRLVGPDFFGCAEPA 484

Query: 470 NS 471
           N+
Sbjct: 485 NT 486


>gi|112382270 matrix metalloproteinase 17 preproprotein [Homo
           sapiens]
          Length = 603

 Score =  214 bits (544), Expect = 2e-55
 Identities = 152/460 (33%), Positives = 218/460 (47%), Gaps = 48/460 (10%)

Query: 28  ENMQLAQAYLNQFYSLEIEGNHLVQSKNRSLIDDKIREMQAFFGLTVTGKLDSNTLEIMK 87
           E++ L   +L++F  L        Q + +  +   I  MQ F GL  TG LD  TL +MK
Sbjct: 47  EDLSLGVEWLSRFGYLPPADPTTGQLQTQEELSKAITAMQQFGGLEATGILDEATLALMK 106

Query: 88  TPRCGVPDV--------GQYGYTLPGWRKYNLTYRIINYTPD--MARAAVDEAIQEGLEV 137
           TPRC +PD+         +       W K NL++R+  +  D  +    V   +   L+V
Sbjct: 107 TPRCSLPDLPVLTQARRRRQAPAPTKWNKRNLSWRVRTFPRDSPLGHDTVRALMYYALKV 166

Query: 138 WSKVTPLKFTKISKGIADIMIAFRTRVHGRCPRYFDGPLGVLGHAFPPG-PGLGGDTHFD 196
           WS + PL F +++   ADI I F    H      FDGP G + HAF PG     GDTHFD
Sbjct: 167 WSDIAPLNFHEVAGSAADIQIDFSKADHND-GYPFDGPGGTVAHAFFPGHHHTAGDTHFD 225

Query: 197 EDENWT---KDGAGFNLFLVAAHEFGHALGLSHSNDQTALMFPNYVSL--DPRKYPLSQD 251
           +DE WT    D  G +LF VA HEFGHA+GLSH     ++M P Y     DP +Y L  +
Sbjct: 226 DDEAWTFRSSDAHGMDLFAVAVHEFGHAIGLSHVAAAHSIMRPYYQGPVGDPLRYGLPYE 285

Query: 252 DINGIQSIYG--------GLPKEP-----------AKPKEPTIPHACDPDLTFDAITTFR 292
           D   +  +YG          P+EP           + P    +PH C     FDA+   R
Sbjct: 286 DKVRVWQLYGVRESVSPTAQPEEPPLLPEPPDNRSSAPPRKDVPHRCSTH--FDAVAQIR 343

Query: 293 REVMFFKGRHLWRIYYD--ITDVEFELIASFWPSLPADL---QAAYENPRD-KILVFKDE 346
            E  FFKG++ WR+  D  +  ++   +  FW  LP  L    A YE   D KI+ FK +
Sbjct: 344 GEAFFFKGKYFWRLTRDRHLVSLQPAQMHRFWRGLPLHLDSVDAVYERTSDHKIVFFKGD 403

Query: 347 NFWMIRGYAVLPDYPKSIHTLGFPGRVKKIDAAVCDKTTRKTYFFVGIWCWRFDEMTQTM 406
            +W+ +   V   YP+ +     P     IDAA       +TYFF     WR+D+ T+ M
Sbjct: 404 RYWVFKDNNVEEGYPRPVSDFSLP--PGGIDAAFSWAHNDRTYFFKDQLYWRYDDHTRHM 461

Query: 407 DKGFPQRVVKHFPGISIRVDAAFQYK-GFFFFSRGSKQFE 445
           D G+P +    + G+   +D A ++  G  +F RG + ++
Sbjct: 462 DPGYPAQ-SPLWRGVPSTLDDAMRWSDGASYFFRGQEYWK 500


>gi|11968059 matrix metalloproteinase 25 preproprotein [Homo
           sapiens]
          Length = 562

 Score =  206 bits (523), Expect = 5e-53
 Identities = 165/517 (31%), Positives = 235/517 (45%), Gaps = 54/517 (10%)

Query: 3   RLLLLFLFFITFSSAFPLVRMTENEENMQLAQAYLNQFYSLEIEGNHLVQSKNRSLIDDK 62
           RL L  L  +    A P      + +++ L   +L ++  L        Q ++   + D 
Sbjct: 2   RLRLRLLALLLLLLAPPARAPKPSAQDVSLGVDWLTRYGYLPPPHPAQAQLQSPEKLRDA 61

Query: 63  IREMQAFFGLTVTGKLDSNTLEIMKTPRCGVPDV-GQYG-------YTLPG--WRKYNLT 112
           I+ MQ F GL  TG++D  T+  M+ PRC +PDV G  G       Y L G  W+K  LT
Sbjct: 62  IKVMQRFAGLPETGRMDPGTVATMRKPRCSLPDVLGVAGLVRRRRRYALSGSVWKKRTLT 121

Query: 113 YRIINY--TPDMARAAVDEAIQEGLEVWSKVTPLKFTKISKGIA---DIMIAFRTRVHGR 167
           +R+ ++  +  +++  V   +   L  W   + L F ++        DI+I F    H +
Sbjct: 122 WRVRSFPQSSQLSQETVRVLMSYALMAWGMESGLTFHEVDSPQGQEPDILIDFARAFH-Q 180

Query: 168 CPRYFDGPLGVLGHAFPPGPG-LGGDTHFDEDENWT---KDGAGFNLFLVAAHEFGHALG 223
               FDG  G L HAF PG   + GDTHFD++E WT   KDG G +LF VA HEFGHALG
Sbjct: 181 DSYPFDGLGGTLAHAFFPGEHPISGDTHFDDEETWTFGSKDGEGTDLFAVAVHEFGHALG 240

Query: 224 LSHSNDQTALMFPNYVSL--DPRKYPLSQDDINGIQSIYGGLPKEP---------AKPKE 272
           L HS+   ++M P Y     DP KY LSQDD +G+Q +YG  P+ P         A P +
Sbjct: 241 LGHSSAPNSIMRPFYQGPVGDPDKYRLSQDDRDGLQQLYGKAPQTPYDKPTRKPLAPPPQ 300

Query: 273 P----------TIPHACDPDLTFDAITTFRREVMFFKGRHLWRIY--YDITDVEFELIAS 320
           P           IP  C+ +  FDAI   R E  FFKG   WR+     +       +  
Sbjct: 301 PPASPTHSPSFPIPDRCEGN--FDAIANIRGETFFFKGPWFWRLQPSGQLVSPRPARLHR 358

Query: 321 FWPSLPAD---LQAAYENPRD-KILVFKDENFWMIRGYAVLPDYPKSIHTLGFPGRVKKI 376
           FW  LPA    +QAAY   RD +IL+F    FW+ +    L    + +  LG P   +++
Sbjct: 359 FWEGLPAQVRVVQAAYARHRDGRILLFSGPQFWVFQD-RQLEGGARPLTELGLPPG-EEV 416

Query: 377 DAAVCDKTTRKTYFFVGIWCWRFDEMTQTMDKGFPQRVVKHFPGISIRVDAAFQYKGFFF 436
           DA        KTY   G   WR+DE     D G+P+ +           D      G  +
Sbjct: 417 DAVFSWPQNGKTYLVRGRQYWRYDEAAARPDPGYPRDLSLWEGAPPSPDDVTVSNAGDTY 476

Query: 437 FSRGSKQFEY---DIKTKNITRIMRTNTWFQCKEPKN 470
           F +G+  + +    IKT+          W  C  P +
Sbjct: 477 FFKGAHYWRFPKNSIKTEPDAPQPMGPNWLDCPAPSS 513


>gi|149999365 matrix metalloproteinase 16 isoform 2 preproprotein
           [Homo sapiens]
          Length = 457

 Score =  204 bits (519), Expect = 2e-52
 Identities = 127/347 (36%), Positives = 169/347 (48%), Gaps = 59/347 (17%)

Query: 54  KNRSLIDDKIREMQAFFGLTVTGKLDSNTLEIMKTPRCGVPD---------VGQYGYTLP 104
           ++   +   +  MQ F+G+ +TGK+D NT++ MK PRCGVPD         + +  Y L 
Sbjct: 64  RSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALT 123

Query: 105 G--WRKYNLTYRIINYTPDMARAAVDEAIQEGLEVWSKVTPLKFTKI-------SKGIAD 155
           G  W+  ++TY I N TP +      +AI+   +VW  VTPL F ++        K   D
Sbjct: 124 GQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVD 183

Query: 156 IMIAFRTRVHGRCPRYFDGPLGVLGHAFPPGPGLGGDTHFDEDENWTKDGA---GFNLFL 212
           I I F +  HG     FDG  G L HA+ PGPG+GGDTHFD DE WT       G +LFL
Sbjct: 184 ITIIFASGFHGDSSP-FDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFL 242

Query: 213 VAAHEFGHALGLSHSNDQTALMFPNYVSLDPRKYPLSQDDINGIQSIYGGLPK------- 265
           VA HE GHALGL HSND TA+M P Y  ++   + L  DD+ GIQ IYG   K       
Sbjct: 243 VAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRP 302

Query: 266 -------------------EPAKPKEPT--------IPHACDPDLTFDAITTFRREVMFF 298
                               P  P+ PT         P+ CD +  F+ +   RRE+  F
Sbjct: 303 LPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGN--FNTLAILRREMFVF 360

Query: 299 KGRHLWRIYYD-ITDVEFELIASFWPSLPADLQAAYENPRDKILVFK 344
           K +  WR+  + + D     I  FW  LP  + A YEN     + FK
Sbjct: 361 KDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFK 407


>gi|4505213 matrix metalloproteinase 19 isoform rasi-1 preproprotein
           [Homo sapiens]
          Length = 508

 Score =  203 bits (516), Expect = 3e-52
 Identities = 157/482 (32%), Positives = 238/482 (49%), Gaps = 54/482 (11%)

Query: 20  LVRMTENEENMQLAQA----YLNQFYSLE--IEGNHLVQSKNRSLIDDKIREMQAFFGLT 73
           L+ MT +   + LA+     YL+Q+  L+  +EG++  + ++   I + +R  Q    L 
Sbjct: 11  LLPMTVSGRVLGLAEVAPVDYLSQYGYLQKPLEGSNNFKPED---ITEALRAFQEASELP 67

Query: 74  VTGKLDSNTLEIMKTPRCGVPDVGQYG---YTLPG-WRKYNLTYRIIN----YTPDMARA 125
           V+G+LD  T   M+ PRCG+ D        Y L G WRK +LT+RI+N      P  ARA
Sbjct: 68  VSGQLDDATRARMRQPRCGLEDPFNQKTLKYLLLGRWRKKHLTFRILNLPSTLPPHTARA 127

Query: 126 AVDEAIQEGLEVWSKVTPLKFTKISKGIADIMIAFRTRVHGRCPRYFDGPLGVLGHAFPP 185
           A+ +A Q+    WS V PL F ++  G ADI ++F  R    C   FDGP  VL HA  P
Sbjct: 128 ALRQAFQD----WSNVAPLTFQEVQAGAADIRLSFHGRQSSYCSNTFDGPGRVLAHADIP 183

Query: 186 GPGLGGDTHFDEDENWTKDG-AGFNLFLVAAHEFGHALGLSHSNDQTALMFPNYVSLDPR 244
                G  HFDEDE WT+    G NL ++AAHE GHALGL HS    ALM P Y    P 
Sbjct: 184 EL---GSVHFDEDEFWTEGTYRGVNLRIIAAHEVGHALGLGHSRYSQALMAPVYEGYRPH 240

Query: 245 KYPLSQDDINGIQSIYG--------------GLPKEPAKPKEPT-IPHACDPDLTFDAIT 289
            + L  DD+ GIQ++YG               LP  P  P EP+ +P  C  +L  DA+ 
Sbjct: 241 -FKLHPDDVAGIQALYGKKSPVIRDEEEEETELPTVPPVPTEPSPMPDPCSSEL--DAMM 297

Query: 290 TF-RREVMFFKGRHLWRIYYDITDVEFELIASFWPSLPADLQAAYENPRDK-ILVFKDEN 347
              R +   FKG ++W +  D        +++ W  LP +L AA  +PR + I  FK + 
Sbjct: 298 LGPRGKTYAFKGDYVWTV-SDSGPGPLFRVSALWEGLPGNLDAAVYSPRTQWIHFFKGDK 356

Query: 348 FWMIRGYAVLPDYPKSIHTLGFPGRVKKIDAAVCDKTTRKTYFFVGIWCWRFDEMTQTMD 407
            W    + + P +PK ++ +        +DAA+     +K + F G   W++DE+ +T  
Sbjct: 357 VWRYINFKMSPGFPKKLNRV-----EPNLDAALYWPLNQKVFLFKGSGYWQWDELARTDF 411

Query: 408 KGFPQRVVKHFPGISIRVDAAFQYK-GFFFFSRGSKQFEYDIKTKNITRIMR--TNTWFQ 464
             +P+ +   F G+  +  AA  ++ G  +F +G   +  + + +      R  ++ W  
Sbjct: 412 SSYPKPIKGLFTGVPNQPSAAMSWQDGRVYFFKGKVYWRLNQQLRVEKGYPRNISHNWMH 471

Query: 465 CK 466
           C+
Sbjct: 472 CR 473


>gi|73808266 matrix metalloproteinase 26 preproprotein [Homo
           sapiens]
          Length = 261

 Score =  182 bits (461), Expect = 8e-46
 Identities = 104/264 (39%), Positives = 142/264 (53%), Gaps = 14/264 (5%)

Query: 1   MKRLLLLFLFFITFSSAFPLVRMTENEENMQLAQAYLNQFYSLEIEGNHLVQSKNRSLID 60
           M+ ++L    F+ +  A P V    + +     + Y +QF+  + E   L Q     L+ 
Sbjct: 1   MQLVILRVTIFLPWCFAVP-VPPAADHKGWDFVEGYFHQFFLTKKESPLLTQETQTQLLQ 59

Query: 61  DKIREMQAFFGLTVTGKLDSNTLEIMKTPRCGVPDVGQYGYTLPG---WRKYNLTYRIIN 117
                    F    T  LD     ++  P CGVPD G      PG   W K+ LTYRIIN
Sbjct: 60  Q--------FHRNGTDLLDMQMHALLHQPHCGVPD-GSDTSISPGRCKWNKHTLTYRIIN 110

Query: 118 YTPDMARAAVDEAIQEGLEVWSKVTPLKFTKISKGIADIMIAFRTRVHGRCPRYFDGPLG 177
           Y  DM  +AV ++I   + +WS VTPL F ++  G ADI ++F    H      FDGP G
Sbjct: 111 YPHDMKPSAVKDSIYNAVSIWSNVTPLIFQQVQNGDADIKVSFWQWAH-EDGWPFDGPGG 169

Query: 178 VLGHAFPPGPGLGGDTHFDEDENWTKDGAGFNLFLVAAHEFGHALGLSHSNDQTALMFPN 237
           +LGHAF P  G  G  HFD++E+W+    G+NLFLVA HE GH+LGL HS +Q+++M+P 
Sbjct: 170 ILGHAFLPNSGNPGVVHFDKNEHWSASDTGYNLFLVATHEIGHSLGLQHSGNQSSIMYPT 229

Query: 238 YVSLDPRKYPLSQDDINGIQSIYG 261
           Y   DPR + LS DDI  IQ +YG
Sbjct: 230 YWYHDPRTFQLSADDIQRIQHLYG 253


>gi|189217853 matrix metalloproteinase 2 isoform b [Homo sapiens]
          Length = 610

 Score =  174 bits (441), Expect = 2e-43
 Identities = 102/272 (37%), Positives = 144/272 (52%), Gaps = 22/272 (8%)

Query: 194 HFDEDENWTK-DGAGFNLFLVAAHEFGHALGLSHSNDQTALMFPNYVSLDPRKYPLSQDD 252
           ++D+D  W      G++LFLVAAHEFGHA+GL HS D  ALM P Y     + + LSQDD
Sbjct: 330 NYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYT--KNFRLSQDD 387

Query: 253 INGIQSIYGGLPK-----EPAKPKEPTIPHACDPDLTFDAITTFRREVMFFKGRHLWRIY 307
           I GIQ +YG  P       P     P  P  C  D+ FD I   R E+ FFK R +WR  
Sbjct: 388 IKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRT- 446

Query: 308 YDITDVEFE----LIASFWPSLPADLQAAYENPRD-KILVFKDENFWMIRGYAVLPDYPK 362
             +T  +      L+A+FWP LP  + A YE P++ K + F    +W+     +   YPK
Sbjct: 447 --VTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPK 504

Query: 363 SIHTLGFPGRVKKIDAAVCDKTTRKTYFFVGIWCWRFDEMTQTMDKGFPQRVVKHFPGIS 422
            + +LG P  V+++DAA      +KTY F G   WR++E+ + MD GFP+ +   +  I 
Sbjct: 505 PLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIP 564

Query: 423 IRVDAA--FQYKGFFFFSRGSKQFEYDIKTKN 452
             +DA    Q  G  +F +G+    Y +K +N
Sbjct: 565 DNLDAVVDLQGGGHSYFFKGA----YYLKLEN 592



 Score =  161 bits (407), Expect = 2e-39
 Identities = 85/169 (50%), Positives = 104/169 (61%), Gaps = 9/169 (5%)

Query: 36  YLNQFYSLEIEGNHLVQSKNRSLIDDKIREMQAFFGLTVTGKLDSNTLEIMKTPRCGVPD 95
           YLN FY    E      S N  ++ D +++MQ FFGL  TG LD NT+E M+ PRCG PD
Sbjct: 3   YLNTFYGCPKE------SCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPD 56

Query: 96  VGQYGY--TLPGWRKYNLTYRIINYTPDMARAAVDEAIQEGLEVWSKVTPLKFTKISKGI 153
           V  Y +    P W K  +TYRII YTPD+    VD+A     +VWS VTPL+F++I  G 
Sbjct: 57  VANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGE 116

Query: 154 ADIMIAFRTRVHGRCPRYFDGPLGVLGHAFPPGPGLGGDTHFDEDENWT 202
           ADIMI F    HG     FDG  G+L HAF PG G+GGD+HFD+DE WT
Sbjct: 117 ADIMINFGRWEHGD-GYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWT 164


>gi|11342666 matrix metalloproteinase 2 isoform a preproprotein
           [Homo sapiens]
          Length = 660

 Score =  174 bits (441), Expect = 2e-43
 Identities = 102/272 (37%), Positives = 144/272 (52%), Gaps = 22/272 (8%)

Query: 194 HFDEDENWTK-DGAGFNLFLVAAHEFGHALGLSHSNDQTALMFPNYVSLDPRKYPLSQDD 252
           ++D+D  W      G++LFLVAAHEFGHA+GL HS D  ALM P Y     + + LSQDD
Sbjct: 380 NYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYT--KNFRLSQDD 437

Query: 253 INGIQSIYGGLPK-----EPAKPKEPTIPHACDPDLTFDAITTFRREVMFFKGRHLWRIY 307
           I GIQ +YG  P       P     P  P  C  D+ FD I   R E+ FFK R +WR  
Sbjct: 438 IKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRT- 496

Query: 308 YDITDVEFE----LIASFWPSLPADLQAAYENPRD-KILVFKDENFWMIRGYAVLPDYPK 362
             +T  +      L+A+FWP LP  + A YE P++ K + F    +W+     +   YPK
Sbjct: 497 --VTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPK 554

Query: 363 SIHTLGFPGRVKKIDAAVCDKTTRKTYFFVGIWCWRFDEMTQTMDKGFPQRVVKHFPGIS 422
            + +LG P  V+++DAA      +KTY F G   WR++E+ + MD GFP+ +   +  I 
Sbjct: 555 PLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIP 614

Query: 423 IRVDAA--FQYKGFFFFSRGSKQFEYDIKTKN 452
             +DA    Q  G  +F +G+    Y +K +N
Sbjct: 615 DNLDAVVDLQGGGHSYFFKGA----YYLKLEN 642



 Score =  164 bits (414), Expect = 2e-40
 Identities = 87/174 (50%), Positives = 107/174 (61%), Gaps = 9/174 (5%)

Query: 31  QLAQAYLNQFYSLEIEGNHLVQSKNRSLIDDKIREMQAFFGLTVTGKLDSNTLEIMKTPR 90
           +LA  YLN FY    E      S N  ++ D +++MQ FFGL  TG LD NT+E M+ PR
Sbjct: 48  ELAVQYLNTFYGCPKE------SCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPR 101

Query: 91  CGVPDVGQYGY--TLPGWRKYNLTYRIINYTPDMARAAVDEAIQEGLEVWSKVTPLKFTK 148
           CG PDV  Y +    P W K  +TYRII YTPD+    VD+A     +VWS VTPL+F++
Sbjct: 102 CGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSR 161

Query: 149 ISKGIADIMIAFRTRVHGRCPRYFDGPLGVLGHAFPPGPGLGGDTHFDEDENWT 202
           I  G ADIMI F    HG     FDG  G+L HAF PG G+GGD+HFD+DE WT
Sbjct: 162 IHDGEADIMINFGRWEHGD-GYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWT 214


>gi|13236530 matrix metalloproteinase 28 isoform 1 preproprotein
           [Homo sapiens]
          Length = 520

 Score =  153 bits (386), Expect = 4e-37
 Identities = 146/501 (29%), Positives = 210/501 (41%), Gaps = 68/501 (13%)

Query: 27  EENMQLAQAYLNQFYSLEIEGNHLVQSKNRSLIDDKIREMQAFFGLTVTGKLDSNTLEIM 86
           +E  + A+A+L ++  L      + ++   +   D IR  Q    L V+G LD  TL  M
Sbjct: 30  QELRKEAEAFLEKYGYLN---EQVPKAPTSTRFSDAIRAFQWVSQLPVSGVLDRATLRQM 86

Query: 87  KTPRCGVPDVGQYG----------------------YTLPG--WRKYNLTYRIINYTPDM 122
             PRCGV D   Y                       +   G  W K +L+YR++N+   +
Sbjct: 87  TRPRCGVTDTNSYAAWAERISDLFARHRTKMRRKKRFAKQGNKWYKQHLSYRLVNWPEHL 146

Query: 123 ARAAVDEAIQEGLEVWSKVTPLKFTKI-SKGIADIMIAFRTRVHGR-CPRYFDGPLGVLG 180
              AV  A++   ++WS V+ L+F +  + G ADI + F    H       FDGP G L 
Sbjct: 147 PEPAVRGAVRAAFQLWSNVSALEFWEAPATGPADIRLTFFQGDHNDGLGNAFDGPGGALA 206

Query: 181 HAFPPGPGLGGDTHFDEDENWTKDGA-GFNLFLVAAHEFGHALGLSHSNDQTALMFPNYV 239
           HAF P  G   + HFD+DE W+     G NLF+V AHE GH LGL+HS    ALM P Y 
Sbjct: 207 HAFLPRRG---EAHFDQDERWSLSRRRGRNLFVVLAHEIGHTLGLTHSPAPRALMAPYYK 263

Query: 240 SLDPRKYPLSQDDINGIQSIYGG---------LPKE-------------PAKPKEPTIPH 277
            L  R   LS DD+  +QS+YG          LP +               +  E   P 
Sbjct: 264 RLG-RDALLSWDDVLAVQSLYGKPLGGSVAVQLPGKLFTDFETWDSYSPQGRRPETQGPK 322

Query: 278 ACDPDLTFDAITTFRREVMF-FKGRHLWRIYYDITDVEFELIASFWPSLPADLQAAYENP 336
            C    +FDAIT  R++ ++ FKG H W +  D    E   +   W  LP +++AA  + 
Sbjct: 323 YCHS--SFDAITVDRQQQLYIFKGSHFWEVAADGNVSEPRPLQERWVGLPPNIEAAAVSL 380

Query: 337 RD-KILVFKDENFWMIRGYAVLPDYPKSIHTLGFPGRVKKIDAAVCDKTTRKTYFFVGIW 395
            D     FK    W  RG   +   P+     G P   +  DAA+     R+   F G  
Sbjct: 381 NDGDFYFFKGGRCWRFRGPKPVWGLPQLCRAGGLP---RHPDAALFFPPLRRLILFKGAR 437

Query: 396 CWRFDEMTQTMDKGFPQRVVKHFPGISIRVDAAF-QYKGFFFFSRGSKQFEYDIKTKNIT 454
            +        ++  +P R ++ + GI   V  A  +  G   F R  + +  D      T
Sbjct: 438 YYVLARGGLQVEPYYP-RSLQDWGGIPEEVSGALPRPDGSIIFFRDDRYWRLDQAKLQAT 496

Query: 455 RIMRTNT---WFQCKEPKNSS 472
              R  T   W  C    + S
Sbjct: 497 TSGRWATELPWMGCWHANSGS 517


>gi|74272287 matrix metalloproteinase 9 preproprotein [Homo sapiens]
          Length = 707

 Score =  140 bits (352), Expect = 4e-33
 Identities = 86/202 (42%), Positives = 120/202 (59%), Gaps = 16/202 (7%)

Query: 26  NEENMQLAQAYLNQF-YSLEIEGNHLVQSKNRSLIDDKIREMQAFFGLTVTGKLDSNTLE 84
           N  + QLA+ YL ++ Y+   E    ++ +++SL    +  +Q    L  TG+LDS TL+
Sbjct: 38  NLTDRQLAEEYLYRYGYTRVAE----MRGESKSL-GPALLLLQKQLSLPETGELDSATLK 92

Query: 85  IMKTPRCGVPDVGQYGYTLPG---WRKYNLTYRIINYTPDMARAAVDEAIQEGLEVWSKV 141
            M+TPRCGVPD+G++  T  G   W  +N+TY I NY+ D+ RA +D+A      +WS V
Sbjct: 93  AMRTPRCGVPDLGRF-QTFEGDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAV 151

Query: 142 TPLKFTKISKGIADIMIAFRTRVHGRCPRYFDGPLGVLGHAFPPGPGLGGDTHFDEDENW 201
           TPL FT++    ADI+I F    HG     FDG  G+L HAFPPGPG+ GD HFD+DE W
Sbjct: 152 TPLTFTRVYSRDADIVIQFGVAEHGD-GYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELW 210

Query: 202 TKDGAGFNLFLVAAHEFGHALG 223
           +  G G    +V    FG+A G
Sbjct: 211 SL-GKG----VVVPTRFGNADG 227



 Score =  108 bits (270), Expect = 1e-23
 Identities = 89/304 (29%), Positives = 128/304 (42%), Gaps = 66/304 (21%)

Query: 193 THFDEDENWTK-DGAGFNLFLVAAHEFGHALGLSHSNDQTALMFPNYVSLDPRKYPLSQD 251
           ++FD D+ W      G++LFLVAAHEFGHALGL HS+   ALM+P Y   +    PL +D
Sbjct: 377 SNFDSDKKWGFCPDQGYSLFLVAAHEFGHALGLDHSSVPEALMYPMYRFTEGP--PLHKD 434

Query: 252 DINGIQSIYGGLPKEPAKPK-----EPTIP------------------------------ 276
           D+NGI+ +YG  P+   +P      +PT P                              
Sbjct: 435 DVNGIRHLYGPRPEPEPRPPTTTTPQPTAPPTVCPTGPPTVHPSERPTAGPTGPPSAGPT 494

Query: 277 -------------------HACDPDLTFDAITTFRREVMFFKGRHLWRIYYDITDVEFE- 316
                               AC+ ++ FDAI     ++  FK    WR            
Sbjct: 495 GPPTAGPSTATTVPLSPVDDACNVNI-FDAIAEIGNQLYLFKDGKYWRFSEGRGSRPQGP 553

Query: 317 -LIASFWPSLPADLQAAYENPRDK-ILVFKDENFWMIRGYAVLPDYPKSIHTLGFPGRVK 374
            LIA  WP+LP  L + +E    K +  F     W+  G +VL   P+ +  LG    V 
Sbjct: 554 FLIADKWPALPRKLDSVFEERLSKKLFFFSGRQVWVYTGASVLG--PRRLDKLGLGADVA 611

Query: 375 KIDAAVCDKTTR-KTYFFVGIWCWRFDEMTQTMDKGFPQRVVKHFPGISIRVDAAFQYKG 433
           ++  A+  ++ R K   F G   WRFD   Q +D      V + FPG+ +     FQY+ 
Sbjct: 612 QVTGAL--RSGRGKMLLFSGRRLWRFDVKAQMVDPRSASEVDRMFPGVPLDTHDVFQYRE 669

Query: 434 FFFF 437
             +F
Sbjct: 670 KAYF 673


>gi|22218341 matrix metalloproteinase 21 preproprotein [Homo
           sapiens]
          Length = 569

 Score =  124 bits (312), Expect = 2e-28
 Identities = 124/458 (27%), Positives = 184/458 (40%), Gaps = 104/458 (22%)

Query: 61  DKIREMQAFFGLTVTGKLDSNTLEIMKTPRCGVPDVGQYGYTLP---------------- 104
           + +R  Q    L  +G+LD+ TL  M  PRCGVPD+     + P                
Sbjct: 87  EAVRRFQRANALPASGELDAATLAAMNRPRCGVPDMRPPPPSAPPSPPGPPPRARSRRSP 146

Query: 105 ---------GWR--------------KYNLTYRIINYTPDMARAAVDEA--IQEGLEVWS 139
                    GW+              K  L++R++        +  D+   +     +WS
Sbjct: 147 RAPLSLSRRGWQPRGYPDGGAAQAFSKRTLSWRLLGEALSSQLSVADQRRIVALAFRMWS 206

Query: 140 KVTPLKFTK--ISKGIA-DIMIAFRTRVHGRCPRYFDGPLGVLGHAFPPGPGLGGDTHFD 196
           +VTPL F +   + G A DI + F    H  CPR FDG      HA+  G     D HFD
Sbjct: 207 EVTPLDFREDLAAPGAAVDIKLGFGRGRHLGCPRAFDGSGQEFAHAWRLG-----DIHFD 261

Query: 197 EDENWTK--DGAGFNLFLVAAHEFGHALGLSHSNDQTALMFPNYVSLDPRKYPLSQDDIN 254
           +DE++T      G +L  VA HE GH LGL H+    ++M PNY+  +P  + L   D  
Sbjct: 262 DDEHFTPPTSDTGISLLKVAVHEIGHVLGLPHTYRTGSIMQPNYIPQEP-AFELDWSDRK 320

Query: 255 GIQSIYGGLPKEPAKPKEPTIPHACDP--DLTFDAITTFRR---EVM------FFKGRHL 303
            IQ +YG                +C+   D  FD I   R    EVM      FF+    
Sbjct: 321 AIQKLYG----------------SCEGSFDTAFDWIRKERNQYGEVMVRFSTYFFRNSWY 364

Query: 304 WRIYYDITDVEFE---LIASFWPSLPADLQAAYEN----PRDKILVFKDENFWMI---RG 353
           W          +     I + WP +P     A+ +     RD+   F+   +W     + 
Sbjct: 365 WLYENRNNRTRYGDPIQILTGWPGIPTHNIDAFVHIWTWKRDERYFFQGNQYWRYDSDKD 424

Query: 354 YAVLPD-----YPKSIHTLGFPGRVKKIDAAVCDKTTRKTYFFVGIWCWRFDEMTQTMDK 408
            A+  D     YPK I + GFPG    +D A  D+  +  YFF     + FD     +  
Sbjct: 425 QALTEDEQGKSYPKLI-SEGFPGIPSPLDTAFYDRRQKLIYFFKESLVFAFDVNRNRVLN 483

Query: 409 GFPQRVVKHFPGISIR------VDAA---FQYKGFFFF 437
            +P+R+ + FP +  +      +D+A   + Y   FFF
Sbjct: 484 SYPKRITEVFPAVIPQNHPFRNIDSAYYSYAYNSIFFF 521


>gi|169203154 PREDICTED: similar to hCG2042634 [Homo sapiens]
          Length = 358

 Score = 86.7 bits (213), Expect = 5e-17
 Identities = 63/208 (30%), Positives = 99/208 (47%), Gaps = 56/208 (26%)

Query: 1   MKRLLLLF-LFFITFSSAFPLVRMTENEENMQLAQAYL-NQFYSLEIEGNHLVQSKNRSL 58
           ++++LL+F L ++T    FP       +E+  +   YL N +Y+L+ E N + + ++ S 
Sbjct: 120 IQQILLVFSLLYLTAQQQFP-------QESFPVK--YLENCYYNLKSEINQIGRQRDSSP 170

Query: 59  IDDKIREMQAFFGLTVTGKLDSNTLEIMKTPRCGVPDVGQYGYTLPGWRKYNLTYRIINY 118
           + +K+++MQ FFGL                                         +  NY
Sbjct: 171 VLEKLKQMQNFFGL-----------------------------------------KDQNY 189

Query: 119 TPDMARAAVDEAIQEGLEVWSKVTPLKFTKISKGIADIMIAF--RTRVHGRCPRYFDGPL 176
            P++ +  VD A  +  E+WS  + L FT+  +   DI+++F     +H   P Y  G  
Sbjct: 190 MPNLPQEDVDRATGKAFELWSNASALTFTRDFESEGDIILSFVFLADLHDNSPFY--GHD 247

Query: 177 GVLGHAFPPGPGLGGDTHFDEDENWTKD 204
           G L HAFPPGPG+GGD HFD DE  TKD
Sbjct: 248 GCLAHAFPPGPGIGGDVHFDNDETRTKD 275



 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 37/101 (36%), Positives = 61/101 (60%), Gaps = 4/101 (3%)

Query: 323 PSLPADLQAAYENPRDKILVFKDENFWMIRGYAVLPDYPKSIHT-LGFPGRVKKIDAAVC 381
           P +  D+   ++N   +   F+    W+++   +L  YP+ +++   FP RVKKIDAA+ 
Sbjct: 258 PGIGGDVH--FDNDETRTKDFRSSKHWVVQEDQLLSGYPRDVYSSFVFPERVKKIDAAIY 315

Query: 382 DKTTRKTYFFVGIWCWRFDEMTQTMDKGFPQRVVKHFPGIS 422
           +K T KT+FFV    WR+DE  Q++D G+P +++   PGIS
Sbjct: 316 EKDTGKTHFFVANEYWRYDENMQSVDAGYP-KIIDDLPGIS 355


>gi|5902004 matrix metalloproteinase 23B precursor [Homo sapiens]
          Length = 390

 Score = 86.7 bits (213), Expect = 5e-17
 Identities = 65/177 (36%), Positives = 90/177 (50%), Gaps = 23/177 (12%)

Query: 106 WRKYNLTYRIINYTPDM-ARAAVDEAIQEGLEVWSKVTPLKFTKIS-KGIADIMIAFRTR 163
           W  +NLTYRI+++  ++ +      A+     +WS V+P  F +++ +  +D+ I F   
Sbjct: 88  WDHFNLTYRILSFPRNLLSPRETRRALAAAFRMWSDVSPFSFREVAPEQPSDLRIGFYPI 147

Query: 164 VHGRC-----PRYFDGPLGVLGHAF-PPGPGLGGDTHFDEDENWT--------KDGAGF- 208
            H  C        FDGP G L HAF PP  G+    HFD+ E W         K G    
Sbjct: 148 NHTDCLVSALHHCFDGPTGELAHAFFPPHGGI----HFDDSEYWVLGPTRYSWKKGVWLT 203

Query: 209 NLFLVAAHEFGHALGLSHSNDQTALMFPNYVSLDPRKYPLSQDDINGIQSIYGGLPK 265
           +L  VAAHE GHALGL HS    ALM  N  +L   K  LSQD++ G+  +YG L +
Sbjct: 204 DLVHVAAHEIGHALGLMHSQHGRALMHLN-ATLRGWK-ALSQDELWGLHRLYGCLDR 258


>gi|239750339 PREDICTED: hypothetical protein XP_002347374 [Homo
           sapiens]
          Length = 183

 Score = 82.0 bits (201), Expect = 1e-15
 Identities = 61/170 (35%), Positives = 90/170 (52%), Gaps = 21/170 (12%)

Query: 20  LVRMTENEENMQLAQA----YLNQFYSLE--IEGNHLVQSKNRSLIDDKIREMQAFFGLT 73
           L+ MT +   + LA+     YL+Q+  L+  +EG++  + ++   I + +R  Q    L 
Sbjct: 11  LLPMTVSGRVLGLAEVAPVDYLSQYGYLQKPLEGSNNFKPED---ITEALRAFQEASELP 67

Query: 74  VTGKLDSNTLEIMKTPRCGVPDVGQYG---YTLPG-WRKYNLTYRIIN----YTPDMARA 125
           V+G+LD  T   M+ PRCG+ D        Y L G WRK +LT+RI+N      P  ARA
Sbjct: 68  VSGQLDDATRARMRQPRCGLEDPFNQKTLKYLLLGRWRKKHLTFRILNLPSTLPPHTARA 127

Query: 126 AVDEAIQEGLEVWSKVTPLKFTKISKGIADIMIAFRTRVHGRCPRYFDGP 175
           A+ +A Q+    WS V PL F ++  G ADI ++F  R    C   FDGP
Sbjct: 128 ALRQAFQD----WSNVAPLTFQEVQAGAADIRLSFHGRQSSYCSNTFDGP 173


>gi|169202084 PREDICTED: similar to hCG2042634 [Homo sapiens]
          Length = 198

 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 43/101 (42%), Positives = 56/101 (55%), Gaps = 4/101 (3%)

Query: 106 WRKYNLTYRIINYTPDMARAAVDEAIQEGLEVWSKVTPLKFTKISKGIADIMIAF--RTR 163
           WR         NY P++ +  VD A  +  E+WSK + L FT+  +   DI+++F     
Sbjct: 17  WRGIQKWQEDQNYMPNLPQEDVDRATGKAFELWSKASALTFTRDFESEGDIILSFVFLAD 76

Query: 164 VHGRCPRYFDGPLGVLGHAFPPGPGLGGDTHFDEDENWTKD 204
           +H   P Y  G  G L HAFPPGPG+GGD HFD DE  TKD
Sbjct: 77  LHDNSPFY--GHDGCLAHAFPPGPGIGGDVHFDNDETRTKD 115



 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 37/101 (36%), Positives = 61/101 (60%), Gaps = 4/101 (3%)

Query: 323 PSLPADLQAAYENPRDKILVFKDENFWMIRGYAVLPDYPKSIHT-LGFPGRVKKIDAAVC 381
           P +  D+   ++N   +   F+    W+++   +L  YP+ +++   FP RVKKIDAA+ 
Sbjct: 98  PGIGGDVH--FDNDETRTKDFRSSKHWVVQEDQLLSGYPRDVYSSFVFPERVKKIDAAIY 155

Query: 382 DKTTRKTYFFVGIWCWRFDEMTQTMDKGFPQRVVKHFPGIS 422
           +K T KT+FFV    WR+DE  Q++D G+P +++   PGIS
Sbjct: 156 EKDTGKTHFFVANEYWRYDENMQSVDAGYP-KIIDDLPGIS 195


>gi|169203660 PREDICTED: similar to hCG2042634 [Homo sapiens]
          Length = 198

 Score = 79.7 bits (195), Expect = 6e-15
 Identities = 42/101 (41%), Positives = 55/101 (54%), Gaps = 4/101 (3%)

Query: 106 WRKYNLTYRIINYTPDMARAAVDEAIQEGLEVWSKVTPLKFTKISKGIADIMIAF--RTR 163
           WR         NY P++ +  VD A  +  E+WS  + L FT+  +   DI+++F     
Sbjct: 17  WRGIQKWQEDQNYMPNLPQEDVDRATGKAFELWSNASALTFTRDFESEGDIILSFVFLAD 76

Query: 164 VHGRCPRYFDGPLGVLGHAFPPGPGLGGDTHFDEDENWTKD 204
           +H   P Y  G  G L HAFPPGPG+GGD HFD DE  TKD
Sbjct: 77  LHDNSPFY--GHDGCLAHAFPPGPGIGGDVHFDNDETRTKD 115



 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 37/101 (36%), Positives = 61/101 (60%), Gaps = 4/101 (3%)

Query: 323 PSLPADLQAAYENPRDKILVFKDENFWMIRGYAVLPDYPKSIHT-LGFPGRVKKIDAAVC 381
           P +  D+   ++N   +   F+    W+++   +L  YP+ +++   FP RVKKIDAA+ 
Sbjct: 98  PGIGGDVH--FDNDETRTKDFRSSKHWVVQEDQLLSGYPRDVYSSFVFPERVKKIDAAIY 155

Query: 382 DKTTRKTYFFVGIWCWRFDEMTQTMDKGFPQRVVKHFPGIS 422
           +K T KT+FFV    WR+DE  Q++D G+P +++   PGIS
Sbjct: 156 EKDTGKTHFFVANEYWRYDENMQSVDAGYP-KIIDDLPGIS 195


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.141    0.445 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,125,268
Number of Sequences: 37866
Number of extensions: 924337
Number of successful extensions: 2397
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 37
Number of HSP's successfully gapped in prelim test: 16
Number of HSP's that attempted gapping in prelim test: 2142
Number of HSP's gapped (non-prelim): 88
length of query: 513
length of database: 18,247,518
effective HSP length: 107
effective length of query: 406
effective length of database: 14,195,856
effective search space: 5763517536
effective search space used: 5763517536
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.