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Search of human proteins with 71773110
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|71773110 apolipoprotein A-IV precursor [Homo sapiens]
(396 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|71773110 apolipoprotein A-IV precursor [Homo sapiens] 763 0.0
gi|63079709 apolipoprotein AV [Homo sapiens] 125 5e-29
gi|4557321 apolipoprotein A-I preproprotein [Homo sapiens] 107 2e-23
gi|4557325 apolipoprotein E precursor [Homo sapiens] 98 1e-20
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 66 5e-11
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 66 5e-11
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 66 5e-11
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 66 5e-11
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 66 5e-11
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 66 6e-11
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 65 1e-10
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 65 1e-10
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 65 1e-10
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 65 1e-10
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 65 1e-10
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 65 1e-10
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 65 1e-10
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 65 1e-10
gi|115648142 centrosomal protein 164kDa [Homo sapiens] 60 3e-09
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 60 3e-09
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 60 4e-09
gi|31982906 cingulin-like 1 [Homo sapiens] 59 6e-09
gi|134304846 Rb1-inducible coiled coil protein 1 isoform 2 [Homo... 57 2e-08
gi|134304842 Rb1-inducible coiled coil protein 1 isoform 1 [Homo... 57 2e-08
gi|64085252 hypothetical protein LOC145508 [Homo sapiens] 57 2e-08
gi|46592991 GRIP1 associated protein 1 isoform 1 [Homo sapiens] 57 3e-08
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 56 5e-08
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 56 5e-08
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 56 5e-08
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 56 5e-08
>gi|71773110 apolipoprotein A-IV precursor [Homo sapiens]
Length = 396
Score = 763 bits (1971), Expect = 0.0
Identities = 396/396 (100%), Positives = 396/396 (100%)
Query: 1 MFLKAVVLTLALVAVAGARAEVSADQVATVMWDYFSQLSNNAKEAVEHLQKSELTQQLNA 60
MFLKAVVLTLALVAVAGARAEVSADQVATVMWDYFSQLSNNAKEAVEHLQKSELTQQLNA
Sbjct: 1 MFLKAVVLTLALVAVAGARAEVSADQVATVMWDYFSQLSNNAKEAVEHLQKSELTQQLNA 60
Query: 61 LFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSEKLKEEIGKELEELRARLLPHANEV 120
LFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSEKLKEEIGKELEELRARLLPHANEV
Sbjct: 61 LFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSEKLKEEIGKELEELRARLLPHANEV 120
Query: 121 SQKIGDNLRELQQRLEPYADQLRTQVSTQAEQLRRQLTPYAQRMERVLRENADSLQASLR 180
SQKIGDNLRELQQRLEPYADQLRTQVSTQAEQLRRQLTPYAQRMERVLRENADSLQASLR
Sbjct: 121 SQKIGDNLRELQQRLEPYADQLRTQVSTQAEQLRRQLTPYAQRMERVLRENADSLQASLR 180
Query: 181 PHADELKAKIDQNVEELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEG 240
PHADELKAKIDQNVEELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEG
Sbjct: 181 PHADELKAKIDQNVEELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEG 240
Query: 241 LTFQMKKNAEELKARISASAEELRQRLAPLAEDVRGNLRGNTEGLQKSLAELGGHLDQQV 300
LTFQMKKNAEELKARISASAEELRQRLAPLAEDVRGNLRGNTEGLQKSLAELGGHLDQQV
Sbjct: 241 LTFQMKKNAEELKARISASAEELRQRLAPLAEDVRGNLRGNTEGLQKSLAELGGHLDQQV 300
Query: 301 EEFRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDKVNSFFSTFKE 360
EEFRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDKVNSFFSTFKE
Sbjct: 301 EEFRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDKVNSFFSTFKE 360
Query: 361 KESQDKTLSLPELEQQQEQQQEQQQEQVQMLAPLES 396
KESQDKTLSLPELEQQQEQQQEQQQEQVQMLAPLES
Sbjct: 361 KESQDKTLSLPELEQQQEQQQEQQQEQVQMLAPLES 396
>gi|63079709 apolipoprotein AV [Homo sapiens]
Length = 366
Score = 125 bits (315), Expect = 5e-29
Identities = 96/338 (28%), Positives = 168/338 (49%), Gaps = 18/338 (5%)
Query: 5 AVVLTLALVAVAGARAEVSADQVATVMWDYFSQLSNNAKEAVEHLQKSELTQQLNALFQD 64
A VLT AL ++ SA Q WDYFSQ S + K VE + + ++ ++ A +D
Sbjct: 5 AAVLTWALALLSA----FSATQARKGFWDYFSQTSGD-KGRVEQIHQQKMARE-PATLKD 58
Query: 65 KLGEVNTYAGDLQKKLVPFATELHERLAKDSEKLKEEIGKELEELRARLLPHANEVSQKI 124
L + +KL P + RL +D ++ ++ +ELEE++ARL P+ E + +
Sbjct: 59 SLEQDLNNMNKFLEKLRPLSGSEAPRLPQDPVGMRRQLQEELEEVKARLQPYMAEAHELV 118
Query: 125 GDNLRELQQRLEPYADQLRTQVSTQAEQLRRQLTPYAQRMERVLRENADSLQASLRPHAD 184
G NL L+Q+L+PY L QV+ + ++L+ QL + + L D A L+
Sbjct: 119 GWNLEGLRQQLKPYTMDLMEQVALRVQELQEQLRVVGEDTKAQLLGGVDEAWALLQ---- 174
Query: 185 ELKAKIDQNVEELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQ 244
L++++ + K PYA+ I + V+EL RS+AP+A + +L+ ++ L+ +
Sbjct: 175 GLQSRVVHHTGRFKELFHPYAESLVSGIGRHVQELHRSVAPHAPASPARLSRCVQVLSRK 234
Query: 245 MKKNAEELKARISASAEELRQRLAPLAEDVRGNLRGNTEGLQKSLAELGGHLDQQVEEFR 304
+ A+ L ARI + ++LR+ L+ G EG L + Q+++ FR
Sbjct: 235 LTLKAKALHARIQQNLDQLREELSRAFAGT-----GTEEGAGPDPQMLSEEVRQRLQAFR 289
Query: 305 RRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSF 342
+ F +A+ Q+ E+++Q+L P GH +F
Sbjct: 290 QDTYLQIAAFTRAIDQETEEVQQQLAP---PPPGHSAF 324
Score = 34.7 bits (78), Expect = 0.15
Identities = 20/87 (22%), Positives = 47/87 (54%), Gaps = 7/87 (8%)
Query: 265 QRLAPLAEDVRGNLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQ 324
++L PL+ L + G+++ L E ++EE + R++PY ++ + +E
Sbjct: 72 EKLRPLSGSEAPRLPQDPVGMRRQLQE-------ELEEVKARLQPYMAEAHELVGWNLEG 124
Query: 325 LRQKLGPHAGDVEGHLSFLEKDLRDKV 351
LRQ+L P+ D+ ++ ++L++++
Sbjct: 125 LRQQLKPYTMDLMEQVALRVQELQEQL 151
>gi|4557321 apolipoprotein A-I preproprotein [Homo sapiens]
Length = 267
Score = 107 bits (266), Expect = 2e-23
Identities = 67/265 (25%), Positives = 130/265 (49%), Gaps = 10/265 (3%)
Query: 3 LKAVVLTLALVAVAGARAEV--SADQVATVMWD--------YFSQLSNNAKEAVEHLQKS 52
+KA VLTLA++ + G++A D+ WD Y L ++ ++ V + S
Sbjct: 1 MKAAVLTLAVLFLTGSQARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGS 60
Query: 53 ELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSEKLKEEIGKELEELRAR 112
L +QLN D V + L+++L P E + L K++E L++E+ K+LEE++A+
Sbjct: 61 ALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAK 120
Query: 113 LLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVSTQAEQLRRQLTPYAQRMERVLRENA 172
+ P+ ++ +K + + +Q++EP +L+ + +L+ +L+P + M R +
Sbjct: 121 VQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHV 180
Query: 173 DSLQASLRPHADELKAKIDQNVEELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQE 232
D+L+ L P++DEL+ ++ +E LK E+ K + + L P +D ++
Sbjct: 181 DALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHLSTLSEKAKPALEDLRQ 240
Query: 233 KLNHQLEGLTFQMKKNAEELKARIS 257
L LE EE +++
Sbjct: 241 GLLPVLESFKVSFLSALEEYTKKLN 265
Score = 68.9 bits (167), Expect = 7e-12
Identities = 44/185 (23%), Positives = 87/185 (47%), Gaps = 15/185 (8%)
Query: 146 VSTQAEQLRRQLTPYAQRMERVLRENADSLQASLRPHADELKAKIDQNVEELKGRLTPYA 205
V++ +LR QL P Q +L + L+ ++ +++EE+K ++ PY
Sbjct: 77 VTSTFSKLREQLGPVTQEF-----------WDNLEKETEGLRQEMSKDLEEVKAKVQPYL 125
Query: 206 DEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELKARISASAEELRQ 265
D+F+ K + +E R+ + P + QE +L L ++ EE++ R A + LR
Sbjct: 126 DDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDALRT 185
Query: 266 RLAPLAEDVRGNLRGNTEGLQKS----LAELGGHLDQQVEEFRRRVEPYGENFNKALVQQ 321
LAP ++++R L E L+++ LAE + + + +P E+ + L+
Sbjct: 186 HLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHLSTLSEKAKPALEDLRQGLLPV 245
Query: 322 MEQLR 326
+E +
Sbjct: 246 LESFK 250
Score = 52.8 bits (125), Expect = 5e-07
Identities = 33/153 (21%), Positives = 71/153 (46%), Gaps = 7/153 (4%)
Query: 212 IDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELKARISASAEELRQRLAPLA 271
+ T +LR L P Q+ + L + EGL +M K+ EE+KA++ ++ +++
Sbjct: 77 VTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEM 136
Query: 272 EDVRGNLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLGP 331
E R + ++ AEL Q++ E + ++ P GE ++ LR L P
Sbjct: 137 ELYR-------QKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLAP 189
Query: 332 HAGDVEGHLSFLEKDLRDKVNSFFSTFKEKESQ 364
++ ++ L+ + L++ + + + K ++
Sbjct: 190 YSDELRQRLAARLEALKENGGARLAEYHAKATE 222
Score = 50.8 bits (120), Expect = 2e-06
Identities = 33/148 (22%), Positives = 74/148 (50%), Gaps = 9/148 (6%)
Query: 216 VEELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELKA--RISASAEELRQRLAPLAED 273
V++L +D+ Q EG + N + L ++++ +LR++L P+ ++
Sbjct: 35 VKDLATVYVDVLKDSGRDYVSQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQE 94
Query: 274 VRGNLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLGPHA 333
NL TEGL++ +++ +EE + +V+PY ++F K ++ME RQK+ P
Sbjct: 95 FWDNLEKETEGLRQEMSK-------DLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLR 147
Query: 334 GDVEGHLSFLEKDLRDKVNSFFSTFKEK 361
+++ +L++K++ +++
Sbjct: 148 AELQEGARQKLHELQEKLSPLGEEMRDR 175
>gi|4557325 apolipoprotein E precursor [Homo sapiens]
Length = 317
Score = 97.8 bits (242), Expect = 1e-20
Identities = 60/265 (22%), Positives = 131/265 (49%), Gaps = 18/265 (6%)
Query: 32 WDYFSQLSNNAKEAVEHLQKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERL 91
WDY + +++ E L S++TQ+L AL + + E+ Y +L+++L P A E RL
Sbjct: 52 WDYLRWVQTLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARL 111
Query: 92 AKDSEKLKEEIGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVSTQAE 151
+K+ + + +G ++E++ RL+ + EV +G + EL+ RL + +LR ++ A+
Sbjct: 112 SKELQAAQARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDAD 171
Query: 152 QLRRQLTPY-------AQRMERVLRENADSLQASLRPHADELKAKIDQNVEELKGRLTPY 204
L+++L Y A+R +RE L R A + + Q ++E R +
Sbjct: 172 DLQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQE---RAQAW 228
Query: 205 ADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELKARISASAEELR 264
+ + ++++ + +D +++ Q+ + ++++ A++++ + A L+
Sbjct: 229 GERLRARMEE--------MGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLK 280
Query: 265 QRLAPLAEDVRGNLRGNTEGLQKSL 289
PL ED++ G E +Q ++
Sbjct: 281 SWFEPLVEDMQRQWAGLVEKVQAAV 305
Score = 53.9 bits (128), Expect = 2e-07
Identities = 53/212 (25%), Positives = 97/212 (45%), Gaps = 25/212 (11%)
Query: 185 ELKAKIDQNVEELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQ 244
EL+A +D+ ++ELK Y E + ++ EE R L+ Q Q +L +E + +
Sbjct: 77 ELRALMDETMKELKA----YKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVCGR 132
Query: 245 MKKNAEELKARISASAEELRQRLAPLAEDVRGNLRGNTEGLQKSLA--ELGGH--LDQQV 300
+ + E++A + S EELR RLA +R L + + LQK LA + G ++ +
Sbjct: 133 LVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGL 192
Query: 301 EEFRRRVEPYGENFNKALVQQMEQLRQKLGPHAGD-VEGHLSFLEKDLRDKVNSFFSTFK 359
R R+ P LV+Q +G AG ++ + LR ++ S +
Sbjct: 193 SAIRERLGP--------LVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMGSRTR 244
Query: 360 EKESQDKTLSLPELEQQQEQQQEQQQEQVQML 391
++ L E+++Q + + + +EQ Q +
Sbjct: 245 DR--------LDEVKEQVAEVRAKLEEQAQQI 268
Score = 39.7 bits (91), Expect = 0.005
Identities = 35/149 (23%), Positives = 64/149 (42%), Gaps = 20/149 (13%)
Query: 226 YAQDTQEKLNHQL--EGLTFQMKKNAEELKARISASAEELRQRLAPLAEDVRGNLRGNTE 283
+ Q E++ +L +T +++ +E + A EL ++L P+AE+ R L ++
Sbjct: 57 WVQTLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARL---SK 113
Query: 284 GLQKSLAELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLGPH----------- 332
LQ + A LG + E+ R+ Y L Q E+LR +L H
Sbjct: 114 ELQAAQARLGADM----EDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRD 169
Query: 333 AGDVEGHLSFLEKDLRDKVNSFFSTFKEK 361
A D++ L+ + R+ S +E+
Sbjct: 170 ADDLQKRLAVYQAGAREGAERGLSAIRER 198
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 66.2 bits (160), Expect = 5e-11
Identities = 87/384 (22%), Positives = 171/384 (44%), Gaps = 47/384 (12%)
Query: 37 QLSNNAKEAVEHLQKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSE 96
Q+S +E + ++ ++ +++L E+ T LQ +L+ +L E+L ++E
Sbjct: 839 QVSRQEEEMMAKEEELVKVREKQLAAENRLTEMET----LQSQLMAEKLQLQEQLQAETE 894
Query: 97 KLKEEIGKELEELRARLLPHANEVSQKIGD-----------------NLRELQQRLEPYA 139
+ E EELRARL E+ + D +++QQ ++
Sbjct: 895 -----LCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELE 949
Query: 140 DQLRTQVSTQAEQLRRQLTPYAQ----RMERVLRENADSLQASLRPHADELKAKIDQNV- 194
+QL + S + + ++T A+ E+++ E+ + A + ++ A+ N+
Sbjct: 950 EQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLT 1009
Query: 195 --EELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEEL 252
EE L ++ + I E LRR + EK +LEG + + EL
Sbjct: 1010 EEEEKSKSLAKLKNKHEAMITDLEERLRRE--EKQRQELEKTRRKLEGDSTDLSDQIAEL 1067
Query: 253 KARISASAEELRQRLAPLAEDVRGNL-RGNTEGLQKSLA-ELGGHLDQQVEEFRRRVEPY 310
+A+I+ EL+ +LA E+++ L R E QK++A + L+ Q+ E + +E
Sbjct: 1068 QAQIA----ELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESE 1123
Query: 311 GENFNKALVQQMEQLRQKLGPHAGDVEGHL--SFLEKDLRDKVNSFFSTFK---EKESQD 365
+ NKA +Q L ++L ++E L + +++LR K + K E+E++
Sbjct: 1124 RASRNKA-EKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKT 1182
Query: 366 KTLSLPELEQQQEQQQEQQQEQVQ 389
+ E+ Q+ Q E+ EQ++
Sbjct: 1183 HEAQIQEMRQKHSQAVEELAEQLE 1206
Score = 57.8 bits (138), Expect = 2e-08
Identities = 80/346 (23%), Positives = 148/346 (42%), Gaps = 49/346 (14%)
Query: 78 KKLVPFATELHERLAKDSEKLKEEIGKELEELRARLLPHANEVSQKIGDNLRELQQRLEP 137
K L+ + + E +AK+ E +K + ++ RL SQ + + L +LQ++L
Sbjct: 835 KPLLQVSRQEEEMMAKEEELVK--VREKQLAAENRLTEMETLQSQLMAEKL-QLQEQL-- 889
Query: 138 YADQLRTQVSTQAEQLRRQLTPYAQRMERVLRENADSLQASLR--PHADELKAKIDQNVE 195
Q T++ +AE+LR +LT Q +E + + ++ H K K+ QN++
Sbjct: 890 ---QAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQ 946
Query: 196 ELKGRL---------------TPYADEFKVKIDQTV-EELRRSLAPYAQDTQEKLNHQLE 239
EL+ +L T A K++ +Q + E+ LA + ++++
Sbjct: 947 ELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTT 1006
Query: 240 GLTFQMKKNAE--ELKARISASAEELRQRL------APLAEDVRGNLRGNTEGLQKSLAE 291
LT + +K+ +LK + A +L +RL E R L G++ L +AE
Sbjct: 1007 NLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAE 1066
Query: 292 LGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQK--LGPHAGDVEGHLSFLEKDLRD 349
L Q+ E + ++ E AL + E+ QK ++E +S L++DL
Sbjct: 1067 ----LQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLES 1122
Query: 350 KVNSFFSTFKEKESQDKTL---------SLPELEQQQEQQQEQQQE 386
+ S K+K + L +L QQE + +++QE
Sbjct: 1123 ERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQE 1168
Score = 56.6 bits (135), Expect = 4e-08
Identities = 85/379 (22%), Positives = 167/379 (44%), Gaps = 58/379 (15%)
Query: 38 LSNNAKEAVEHLQKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSEK 97
L+ +EA+E QK+EL ++LN F+ ++ ++ + D+ K + HE EK
Sbjct: 1481 LARALEEAME--QKAEL-ERLNKQFRTEMEDLMSSKDDVGKSV-------HEL-----EK 1525
Query: 98 LKEEIGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVS---TQAEQLR 154
K + +++EE++ +L +E+ LR L+ L+ Q + Q+E+ +
Sbjct: 1526 SKRALEQQVEEMKTQLEELEDELQATEDAKLR-LEVNLQAMKAQFERDLQGRDEQSEEKK 1584
Query: 155 RQLTPYAQRMERVLRENADSLQASLRPHADELKAKIDQNVEELKGRLTPYADEFKVKIDQ 214
+QL + ME L + + R A + K++ ++++L+ + D D+
Sbjct: 1585 KQLVRQVREMEAELED-----ERKQRSMAVAARKKLEMDLKDLEAHI----DSANKNRDE 1635
Query: 215 TVEELRRSLAPYAQDTQEKLNH---QLEGLTFQMKKNAEELKARISASAEELRQRLAPLA 271
+++LR+ L +D +L+ E + Q K+N ++LK+ + A +L++ LA A
Sbjct: 1636 AIKQLRK-LQAQMKDCMRELDDTRASREEILAQAKENEKKLKS-MEAEMIQLQEELAA-A 1692
Query: 272 EDVRGNLRGNTEGLQKSLAELGG-----------------HLDQQVEEFRRRVEPYGENF 314
E + + + L +A G L++++EE + E +
Sbjct: 1693 ERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRL 1752
Query: 315 NKALVQQMEQLRQKLG---PHAGDVEGHLSFLE---KDLRDKVNSFFSTFKEKESQDKTL 368
KA +Q ++Q+ L HA E LE K+L+ K+ T K K T
Sbjct: 1753 KKANLQ-IDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITA 1811
Query: 369 SLPELEQQQEQQQEQQQEQ 387
++ Q +EQ + +E+
Sbjct: 1812 LEAKIAQLEEQLDNETKER 1830
Score = 54.3 bits (129), Expect = 2e-07
Identities = 81/345 (23%), Positives = 153/345 (44%), Gaps = 38/345 (11%)
Query: 61 LFQDKLGEVNTYAGDLQKKLVPFAT--ELHERLAKDSE---KLKEEIGKELEELRARLLP 115
L +D++ E T + ++K A HE + D E + +E+ +ELE+ R +L
Sbjct: 996 LLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEG 1055
Query: 116 HANEVSQKIGDNLRELQQRLEPYADQLRTQVSTQAEQLRRQLTPYAQRMERVLRENADSL 175
+ ++S D + ELQ ++ +L+ Q++ + E+L+ L RV E A
Sbjct: 1056 DSTDLS----DQIAELQAQIA----ELKMQLAKKEEELQAALA-------RVEEEAAQKN 1100
Query: 176 QASLRPHADELKAKIDQNVEELKGRLTPY--ADEFKVKIDQTVEELRRSLAPYAQDT--Q 231
A + EL+++I + E+L+ A++ K + + +E L+ L T Q
Sbjct: 1101 MALKKIR--ELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQ 1158
Query: 232 EKLNHQLEGLTFQMKKNAEELKARISASAEELRQRLAPLAEDVRGNL------RGNTEGL 285
++L + E +KK EE A +E+RQ+ + E++ L + N E
Sbjct: 1159 QELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKA 1218
Query: 286 QKSLAELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLGPH---AGDVEGHLSF 342
+++L G L +V+ + + E+ K + Q+++L+ K ++ ++
Sbjct: 1219 KQTLENERGELANEVKVLLQG-KGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTK 1277
Query: 343 LEKDLRDKVNSFFSTFKEKESQDKTLSLPELEQQQEQQQEQQQEQ 387
L+ +L D V S K S+ T LE Q + QE QE+
Sbjct: 1278 LQVEL-DNVTGLLSQSDSKSSK-LTKDFSALESQLQDTQELLQEE 1320
Score = 46.2 bits (108), Expect = 5e-05
Identities = 64/255 (25%), Positives = 121/255 (47%), Gaps = 21/255 (8%)
Query: 86 ELHERLAKDSEKLKEEIGKELEELRA---RLLPHANEVSQKIGDNLRELQQRLEPYADQL 142
E ++L K ++K+ + +EL++ RA +L A E +K+ E+ Q E A
Sbjct: 1635 EAIKQLRKLQAQMKDCM-RELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAE 1693
Query: 143 RTQVSTQAEQLRRQLTPYAQRMERVLRENADSLQASLRPHADELKAKIDQNVEELKGRLT 202
R + QA+Q R +L A + + A +L+ R A A++++ +EE +G
Sbjct: 1694 RAK--RQAQQERDEL---ADEIANSSGKGALALEEKRRLEARI--AQLEEELEEEQGNTE 1746
Query: 203 PYADEFK---VKIDQ--TVEELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELKARIS 257
D K ++IDQ T L RS A ++ +++L Q + L ++++ +K++
Sbjct: 1747 LINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYK 1806
Query: 258 ASAEELRQRLAPLAEDVRGNLRGNTEGLQKSLAELGGHLDQ---QVEEFRRRVEPYGENF 314
AS L ++A L E + + + K + L QV++ RR E Y +
Sbjct: 1807 ASITALEAKIAQLEEQLDNETK-ERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQA 1865
Query: 315 NKALVQQMEQLRQKL 329
+KA +++QL+++L
Sbjct: 1866 DKAST-RLKQLKRQL 1879
Score = 43.5 bits (101), Expect = 3e-04
Identities = 58/293 (19%), Positives = 124/293 (42%), Gaps = 39/293 (13%)
Query: 3 LKAVVLTLALVAVAGARAEVSADQVATVMWDYFSQLSNNAKEAVEHLQKSE-----LTQQ 57
++A ++ L A RA+ A Q + D + S A+E ++ E L ++
Sbjct: 1678 MEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEE 1737
Query: 58 LNA------LFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSEKLKEEIGKELEELRA 111
L L D+L + N + L L A+ +E ++++ ++ +EL+
Sbjct: 1738 LEEEQGNTELINDRLKKANLQIDQINTDL-----NLERSHAQKNENARQQLERQNKELKV 1792
Query: 112 RLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVSTQAEQLRRQLTPYAQRMERVLREN 171
+L V K ++ L+ ++ +QL + + + + +Q+ ++++ VL +
Sbjct: 1793 KLQEMEGTVKSKYKASITALEAKIAQLEEQLDNE-TKERQAACKQVRRTEKKLKDVLLQV 1851
Query: 172 ADSLQASLRPHADELKAKIDQNVEELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQ 231
D R +A++ K + D+ LK + K ++++ EE +R A ++
Sbjct: 1852 DDE-----RRNAEQYKDQADKASTRLK--------QLKRQLEEAEEEAQR-----ANASR 1893
Query: 232 EKLNHQLEGLTFQMKKNAEELKARISASAEELRQRLAPLAEDVRGNLRGNTEG 284
KL +LE T + A+ + +S+ +LR+ P R +G +G
Sbjct: 1894 RKLQRELEDAT----ETADAMNREVSSLKNKLRRGDLPFVVPRRMARKGAGDG 1942
Score = 43.1 bits (100), Expect = 4e-04
Identities = 80/349 (22%), Positives = 142/349 (40%), Gaps = 66/349 (18%)
Query: 51 KSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSEKLKEEIGKELEELR 110
K+ L Q+L+ L D L A +L+KK F L E ++ I + E R
Sbjct: 1415 KTRLQQELDDLLVD-LDHQRQSACNLEKKQKKFDQLLAE---------EKTISAKYAEER 1464
Query: 111 ARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVSTQAEQLRRQLTPYAQRMERVLRE 170
R A E K R L++ +E A+ E+L +Q + ME ++
Sbjct: 1465 DRAEAEAREKETKALSLARALEEAMEQKAE---------LERLNKQ---FRTEMEDLM-S 1511
Query: 171 NADSLQASLRPHADELKAKIDQNVEELKGRLTPYADEFKVKIDQTVE---ELRRSLAPYA 227
+ D + S+ ++ K ++Q VEE+K +L DE + D + L+ A +
Sbjct: 1512 SKDDVGKSVH-ELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFE 1570
Query: 228 QDTQEKLNHQLEGLTFQMKKNAEELKARISASAEELRQRLAPLAEDVRGNLRGNTEGLQK 287
+D Q + + Q E Q+ + E++A + +E +QR +A + L+
Sbjct: 1571 RDLQGR-DEQSEEKKKQLVRQVREMEAELE---DERKQRSMAVAA---------RKKLEM 1617
Query: 288 SLAELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDL 347
L +L H+D + NK + ++QLR KL D L D
Sbjct: 1618 DLKDLEAHID---------------SANKNRDEAIKQLR-KLQAQMKDCMRELD----DT 1657
Query: 348 RDKVNSFFSTFKEKESQDKTLSLPELEQQQE------QQQEQQQEQVQM 390
R + KE E + K++ ++ Q+E +++ QQE+ ++
Sbjct: 1658 RASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDEL 1706
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 66.2 bits (160), Expect = 5e-11
Identities = 95/440 (21%), Positives = 184/440 (41%), Gaps = 75/440 (17%)
Query: 17 GARAEVSADQVATVMWDYFSQLSNNAKEAVEHLQKSELTQQLNA--------LFQDKLGE 68
G + + ++A M D QL + A + LQ ++T + + D+ +
Sbjct: 938 GQQLQAERKKMAQQMLDLEEQLEEE-EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNK 996
Query: 69 VNTYAGDLQKKLVPFATEL--HERLAKDSEKLKEEIGKELEELRARLLPHANEVSQKIGD 126
++ L++++ T L E AK+ KLK + + EL RL + +K
Sbjct: 997 LSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRL-----KKEEKSRQ 1051
Query: 127 NLRELQQRLEPYADQLRTQVSTQAEQLRRQLTPYAQRMERVLRENADSLQASLRPHADEL 186
L +L+++LE A Q++ Q+ ++ L + + LQA+L DE+
Sbjct: 1052 ELEKLKRKLEGDASDFHEQIADLQAQIAE--------LKMQLAKKEEELQAALARLDDEI 1103
Query: 187 KAKID--QNVEELKGRLTPY-------------ADEFKVKIDQTVEELRRSLAPYAQDT- 230
K + + + EL+G ++ A++ K + + +E L+ L T
Sbjct: 1104 AQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTA 1163
Query: 231 -QEKLNHQLEGLTFQMKKNAEELKARISASAEELRQRLAPLAEDV----------RGNLR 279
Q++L + E +KK +E A +E+RQ+ A E++ + NL
Sbjct: 1164 TQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD 1223
Query: 280 GNTEGLQKSLAELGGHL------DQQVEEFRRRVEPY----------GENFNKALVQQME 323
N + L+K A+L G L Q+VE ++++E GE L ++
Sbjct: 1224 KNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVH 1283
Query: 324 QLRQKLGPHAG---DVEGHLSFLEKDLRDKVNSFFST--FKEKESQDK---TLSLPELEQ 375
+L+ ++ G + EG L KD+ + T ++E++ K + L +LE+
Sbjct: 1284 KLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEE 1343
Query: 376 QQEQQQEQQQEQVQMLAPLE 395
++ Q+Q E+++ LE
Sbjct: 1344 ERNSLQDQLDEEMEAKQNLE 1363
Score = 60.1 bits (144), Expect = 3e-09
Identities = 85/383 (22%), Positives = 159/383 (41%), Gaps = 75/383 (19%)
Query: 40 NNAKEAVEHLQKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSEKLK 99
N KE + + S+LT++ N L + E YA A E+ RLA ++L+
Sbjct: 873 NELKELEQ--KHSQLTEEKNLLQEQLQAETELYAE---------AEEMRVRLAAKKQELE 921
Query: 100 EEIGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVSTQAEQLRRQLTP 159
E L E+ AR L + Q++ +++ Q++ +QL + + + + ++T
Sbjct: 922 E----ILHEMEAR-LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTA 976
Query: 160 YAQ-------------------RMERVLRENADSLQASLRPHADELKAKIDQNVEELKGR 200
A+ + ++L E L +L +E KAK N+ +LK +
Sbjct: 977 EAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLA--EEEEKAK---NLTKLKNK 1031
Query: 201 LTPYADEFKVKID------QTVEELRRSLAPYAQDTQEK---LNHQLEGLTFQMKKNAEE 251
E +V++ Q +E+L+R L A D E+ L Q+ L Q+ K EE
Sbjct: 1032 HESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE 1091
Query: 252 LKARISASAEELRQRLAPLAEDVRGNLRGNTEGLQKSLAELGGHLDQQVEEF--RRRVEP 309
L+A ++ +E+ Q+ L K + EL GH+ E+ R
Sbjct: 1092 LQAALARLDDEIAQKNNAL----------------KKIRELEGHISDLQEDLDSERAARN 1135
Query: 310 YGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDKVNSFFSTFK---EKESQDK 366
E + L +++E L+ +L + +++LR K + K ++E++
Sbjct: 1136 KAEKQKRDLGEELEALKTELEDTLDS-----TATQQELRAKREQEVTVLKKALDEETRSH 1190
Query: 367 TLSLPELEQQQEQQQEQQQEQVQ 389
+ E+ Q+ Q E+ EQ++
Sbjct: 1191 EAQVQEMRQKHAQAVEELTEQLE 1213
Score = 55.8 bits (133), Expect = 6e-08
Identities = 78/363 (21%), Positives = 156/363 (42%), Gaps = 31/363 (8%)
Query: 42 AKEAVEHLQKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSEKLKEE 101
A+ E L+ E ++ N + + ++ ++ + D+ K + E+ + E EE
Sbjct: 1489 ARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHEL-----EKSKRALETQMEE 1543
Query: 102 IGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVSTQAEQLRRQLTPYA 161
+ +LEEL L + ++ N++ L+ + E Q + QL+RQL Y
Sbjct: 1544 MKTQLEELEDELQA-TEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE 1602
Query: 162 QRMERVLRENADSLQASLRPHAD--ELKAKIDQNV---EELKGRLTPYADEFKVKIDQTV 216
+E ++ A + A + D +L+ + D + EE +L + K + +
Sbjct: 1603 TELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK-DFQREL 1661
Query: 217 EELRRS---LAPYAQDTQEKLNHQLEGLTFQMKKN---AEELKARISASAEELRQRLAPL 270
E+ R S + A++ ++K LE Q++++ AE + + EEL + LA
Sbjct: 1662 EDARASRDEIFATAKENEKKAK-SLEADLMQLQEDLAAAERARKQADLEKEELAEELASS 1720
Query: 271 AEDVRGNLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLG 330
R L+ L+ +A+L ++++EE + +E + KA QQ EQL +L
Sbjct: 1721 LSG-RNALQDEKRRLEARIAQL----EEELEEEQGNMEAMSDRVRKA-TQQAEQLSNELA 1774
Query: 331 PHAGDVEGHLSFLE------KDLRDKVNSFFSTFKEKESQDKTLSLPELEQQQEQQQEQQ 384
+ + S + K+LR K++ K K ++ Q +EQ +++
Sbjct: 1775 TERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEA 1834
Query: 385 QEQ 387
+E+
Sbjct: 1835 REK 1837
Score = 48.9 bits (115), Expect = 8e-06
Identities = 54/214 (25%), Positives = 100/214 (46%), Gaps = 31/214 (14%)
Query: 89 ERLAKDSEKLKEEIGKEL--------------EELRARLLPHANEVSQKIG------DNL 128
ER K ++ KEE+ +EL L AR+ E+ ++ G D +
Sbjct: 1700 ERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRV 1759
Query: 129 RELQQRLEPYADQLRTQVST--QAEQLRRQLTPYAQRMERVLRENADSLQASLRPHADEL 186
R+ Q+ E +++L T+ ST + E R+QL + + L E ++++ + L
Sbjct: 1760 RKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAAL 1819
Query: 187 KAKIDQNVE--ELKGRLTPYADEFKVKIDQTVEEL------RRSLAPYAQDTQEKLNHQL 238
+AKI Q E E + R A + + D+ ++E+ R +A ++ EK N ++
Sbjct: 1820 EAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARV 1879
Query: 239 EGLTFQMKKNAEELKARISASAEELRQRLAPLAE 272
+ L Q+++ AEE RI+A+ +L++ L E
Sbjct: 1880 KQLKRQLEE-AEEESQRINANRRKLQRELDEATE 1912
Score = 47.0 bits (110), Expect = 3e-05
Identities = 78/375 (20%), Positives = 149/375 (39%), Gaps = 74/375 (19%)
Query: 90 RLAKDSEKLKEEIGKELEELRARLLPHANEVSQKIGDNLRELQ------QRLEPYADQLR 143
+L ++ L++++ +E+E + L H + ++ ++ D+ ++LQ + LE + +
Sbjct: 1340 QLEEERNSLQDQLDEEMEA-KQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQ 1398
Query: 144 TQVSTQAEQLRRQLTPY--AQRMERVLRENADSL------QASLRPHADELKAKIDQNVE 195
++ +Q + Y ++ + L++ D L Q L + ++ + K DQ +
Sbjct: 1399 KEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA 1458
Query: 196 ELKGRLTPYADEFKVKIDQTVEELRRSLA-----PYAQDTQEKLNHQLEGLTFQMK---- 246
E K + YADE + E+ ++L+ A + +E+L + L +M+
Sbjct: 1459 EEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVS 1518
Query: 247 ------KNAEEL---KARISASAEELRQRLAPL------AEDVRGNLRGNTEGLQKSLAE 291
KN EL K + EE++ +L L ED + L N + L+
Sbjct: 1519 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1578
Query: 292 LGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLE------- 344
D+Q EE RR+++ + L + +Q R +EG L LE
Sbjct: 1579 DLQARDEQNEEKRRQLQRQLHEYETELEDERKQ-RALAAAAKKKLEGDLKDLELQADSAI 1637
Query: 345 ------------------------KDLRDKVNSFFSTFKEKESQDKTLSLPELEQQQEQQ 380
+D R + F+T KE E + K+L E + Q Q+
Sbjct: 1638 KGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSL---EADLMQLQE 1694
Query: 381 QEQQQEQVQMLAPLE 395
E+ + A LE
Sbjct: 1695 DLAAAERARKQADLE 1709
Score = 40.4 bits (93), Expect = 0.003
Identities = 71/320 (22%), Positives = 141/320 (44%), Gaps = 47/320 (14%)
Query: 102 IGKELEELRARLLPHANEVSQ-KIGDNLRELQQRLEPY----ADQLRTQVSTQAEQLRRQ 156
IG+ R +L H E KI D + Q Y A R Q T + ++R
Sbjct: 763 IGQSKIFFRTGVLAHLEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRN 822
Query: 157 LTPYAQRME----RVLRENADSLQASLRPHADELKAKIDQNVEELKGRLTPYADEFKVKI 212
Y + R+ + LQ + + +E++AK D+ +++ K R + K
Sbjct: 823 CAAYLKLRNWQWWRLFTKVKPLLQVTRQE--EEMQAKEDE-LQKTKER--------QQKA 871
Query: 213 DQTVEELRRSLAPYAQDTQEK--LNHQLEGLTFQMKKNAEELKARISASAEELRQRLAPL 270
+ ++EL + ++Q T+EK L QL+ T ++ AEE++ R++A +EL + L +
Sbjct: 872 ENELKELEQK---HSQLTEEKNLLQEQLQAET-ELYAEAEEMRVRLAAKKQELEEILHEM 927
Query: 271 ------AEDVRGNLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQ 324
ED L+ + + + + +L L++ EE R+ + +A ++++E
Sbjct: 928 EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE--EEAARQKLQLEKVTAEAKIKKLED 985
Query: 325 LRQKLGPHAGDVEGHLSFLEKDLRDKVNSFFSTFKEKESQDKTLS---------LPELEQ 375
+ D LS K L ++++ + E+E + K L+ + ELE
Sbjct: 986 EILVM----DDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEV 1041
Query: 376 QQEQQQEQQQEQVQMLAPLE 395
+ +++++ +QE ++ LE
Sbjct: 1042 RLKKEEKSRQELEKLKRKLE 1061
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 66.2 bits (160), Expect = 5e-11
Identities = 95/440 (21%), Positives = 184/440 (41%), Gaps = 75/440 (17%)
Query: 17 GARAEVSADQVATVMWDYFSQLSNNAKEAVEHLQKSELTQQLNA--------LFQDKLGE 68
G + + ++A M D QL + A + LQ ++T + + D+ +
Sbjct: 945 GQQLQAERKKMAQQMLDLEEQLEEE-EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNK 1003
Query: 69 VNTYAGDLQKKLVPFATEL--HERLAKDSEKLKEEIGKELEELRARLLPHANEVSQKIGD 126
++ L++++ T L E AK+ KLK + + EL RL + +K
Sbjct: 1004 LSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRL-----KKEEKSRQ 1058
Query: 127 NLRELQQRLEPYADQLRTQVSTQAEQLRRQLTPYAQRMERVLRENADSLQASLRPHADEL 186
L +L+++LE A Q++ Q+ ++ L + + LQA+L DE+
Sbjct: 1059 ELEKLKRKLEGDASDFHEQIADLQAQIAE--------LKMQLAKKEEELQAALARLDDEI 1110
Query: 187 KAKID--QNVEELKGRLTPY-------------ADEFKVKIDQTVEELRRSLAPYAQDT- 230
K + + + EL+G ++ A++ K + + +E L+ L T
Sbjct: 1111 AQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTA 1170
Query: 231 -QEKLNHQLEGLTFQMKKNAEELKARISASAEELRQRLAPLAEDV----------RGNLR 279
Q++L + E +KK +E A +E+RQ+ A E++ + NL
Sbjct: 1171 TQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD 1230
Query: 280 GNTEGLQKSLAELGGHL------DQQVEEFRRRVEPY----------GENFNKALVQQME 323
N + L+K A+L G L Q+VE ++++E GE L ++
Sbjct: 1231 KNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVH 1290
Query: 324 QLRQKLGPHAG---DVEGHLSFLEKDLRDKVNSFFST--FKEKESQDK---TLSLPELEQ 375
+L+ ++ G + EG L KD+ + T ++E++ K + L +LE+
Sbjct: 1291 KLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEE 1350
Query: 376 QQEQQQEQQQEQVQMLAPLE 395
++ Q+Q E+++ LE
Sbjct: 1351 ERNSLQDQLDEEMEAKQNLE 1370
Score = 60.1 bits (144), Expect = 3e-09
Identities = 85/383 (22%), Positives = 159/383 (41%), Gaps = 75/383 (19%)
Query: 40 NNAKEAVEHLQKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSEKLK 99
N KE + + S+LT++ N L + E YA A E+ RLA ++L+
Sbjct: 880 NELKELEQ--KHSQLTEEKNLLQEQLQAETELYAE---------AEEMRVRLAAKKQELE 928
Query: 100 EEIGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVSTQAEQLRRQLTP 159
E L E+ AR L + Q++ +++ Q++ +QL + + + + ++T
Sbjct: 929 E----ILHEMEAR-LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTA 983
Query: 160 YAQ-------------------RMERVLRENADSLQASLRPHADELKAKIDQNVEELKGR 200
A+ + ++L E L +L +E KAK N+ +LK +
Sbjct: 984 EAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLA--EEEEKAK---NLTKLKNK 1038
Query: 201 LTPYADEFKVKID------QTVEELRRSLAPYAQDTQEK---LNHQLEGLTFQMKKNAEE 251
E +V++ Q +E+L+R L A D E+ L Q+ L Q+ K EE
Sbjct: 1039 HESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE 1098
Query: 252 LKARISASAEELRQRLAPLAEDVRGNLRGNTEGLQKSLAELGGHLDQQVEEF--RRRVEP 309
L+A ++ +E+ Q+ L K + EL GH+ E+ R
Sbjct: 1099 LQAALARLDDEIAQKNNAL----------------KKIRELEGHISDLQEDLDSERAARN 1142
Query: 310 YGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDKVNSFFSTFK---EKESQDK 366
E + L +++E L+ +L + +++LR K + K ++E++
Sbjct: 1143 KAEKQKRDLGEELEALKTELEDTLDS-----TATQQELRAKREQEVTVLKKALDEETRSH 1197
Query: 367 TLSLPELEQQQEQQQEQQQEQVQ 389
+ E+ Q+ Q E+ EQ++
Sbjct: 1198 EAQVQEMRQKHAQAVEELTEQLE 1220
Score = 55.8 bits (133), Expect = 6e-08
Identities = 78/363 (21%), Positives = 156/363 (42%), Gaps = 31/363 (8%)
Query: 42 AKEAVEHLQKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSEKLKEE 101
A+ E L+ E ++ N + + ++ ++ + D+ K + E+ + E EE
Sbjct: 1496 ARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHEL-----EKSKRALETQMEE 1550
Query: 102 IGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVSTQAEQLRRQLTPYA 161
+ +LEEL L + ++ N++ L+ + E Q + QL+RQL Y
Sbjct: 1551 MKTQLEELEDELQA-TEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE 1609
Query: 162 QRMERVLRENADSLQASLRPHAD--ELKAKIDQNV---EELKGRLTPYADEFKVKIDQTV 216
+E ++ A + A + D +L+ + D + EE +L + K + +
Sbjct: 1610 TELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK-DFQREL 1668
Query: 217 EELRRS---LAPYAQDTQEKLNHQLEGLTFQMKKN---AEELKARISASAEELRQRLAPL 270
E+ R S + A++ ++K LE Q++++ AE + + EEL + LA
Sbjct: 1669 EDARASRDEIFATAKENEKKAK-SLEADLMQLQEDLAAAERARKQADLEKEELAEELASS 1727
Query: 271 AEDVRGNLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLG 330
R L+ L+ +A+L ++++EE + +E + KA QQ EQL +L
Sbjct: 1728 LSG-RNALQDEKRRLEARIAQL----EEELEEEQGNMEAMSDRVRKA-TQQAEQLSNELA 1781
Query: 331 PHAGDVEGHLSFLE------KDLRDKVNSFFSTFKEKESQDKTLSLPELEQQQEQQQEQQ 384
+ + S + K+LR K++ K K ++ Q +EQ +++
Sbjct: 1782 TERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEA 1841
Query: 385 QEQ 387
+E+
Sbjct: 1842 REK 1844
Score = 48.9 bits (115), Expect = 8e-06
Identities = 54/214 (25%), Positives = 100/214 (46%), Gaps = 31/214 (14%)
Query: 89 ERLAKDSEKLKEEIGKEL--------------EELRARLLPHANEVSQKIG------DNL 128
ER K ++ KEE+ +EL L AR+ E+ ++ G D +
Sbjct: 1707 ERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRV 1766
Query: 129 RELQQRLEPYADQLRTQVST--QAEQLRRQLTPYAQRMERVLRENADSLQASLRPHADEL 186
R+ Q+ E +++L T+ ST + E R+QL + + L E ++++ + L
Sbjct: 1767 RKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAAL 1826
Query: 187 KAKIDQNVE--ELKGRLTPYADEFKVKIDQTVEEL------RRSLAPYAQDTQEKLNHQL 238
+AKI Q E E + R A + + D+ ++E+ R +A ++ EK N ++
Sbjct: 1827 EAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARV 1886
Query: 239 EGLTFQMKKNAEELKARISASAEELRQRLAPLAE 272
+ L Q+++ AEE RI+A+ +L++ L E
Sbjct: 1887 KQLKRQLEE-AEEESQRINANRRKLQRELDEATE 1919
Score = 47.0 bits (110), Expect = 3e-05
Identities = 78/375 (20%), Positives = 149/375 (39%), Gaps = 74/375 (19%)
Query: 90 RLAKDSEKLKEEIGKELEELRARLLPHANEVSQKIGDNLRELQ------QRLEPYADQLR 143
+L ++ L++++ +E+E + L H + ++ ++ D+ ++LQ + LE + +
Sbjct: 1347 QLEEERNSLQDQLDEEMEA-KQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQ 1405
Query: 144 TQVSTQAEQLRRQLTPY--AQRMERVLRENADSL------QASLRPHADELKAKIDQNVE 195
++ +Q + Y ++ + L++ D L Q L + ++ + K DQ +
Sbjct: 1406 KEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA 1465
Query: 196 ELKGRLTPYADEFKVKIDQTVEELRRSLA-----PYAQDTQEKLNHQLEGLTFQMK---- 246
E K + YADE + E+ ++L+ A + +E+L + L +M+
Sbjct: 1466 EEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVS 1525
Query: 247 ------KNAEEL---KARISASAEELRQRLAPL------AEDVRGNLRGNTEGLQKSLAE 291
KN EL K + EE++ +L L ED + L N + L+
Sbjct: 1526 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1585
Query: 292 LGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLE------- 344
D+Q EE RR+++ + L + +Q R +EG L LE
Sbjct: 1586 DLQARDEQNEEKRRQLQRQLHEYETELEDERKQ-RALAAAAKKKLEGDLKDLELQADSAI 1644
Query: 345 ------------------------KDLRDKVNSFFSTFKEKESQDKTLSLPELEQQQEQQ 380
+D R + F+T KE E + K+L E + Q Q+
Sbjct: 1645 KGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSL---EADLMQLQE 1701
Query: 381 QEQQQEQVQMLAPLE 395
E+ + A LE
Sbjct: 1702 DLAAAERARKQADLE 1716
Score = 40.4 bits (93), Expect = 0.003
Identities = 71/320 (22%), Positives = 141/320 (44%), Gaps = 47/320 (14%)
Query: 102 IGKELEELRARLLPHANEVSQ-KIGDNLRELQQRLEPY----ADQLRTQVSTQAEQLRRQ 156
IG+ R +L H E KI D + Q Y A R Q T + ++R
Sbjct: 770 IGQSKIFFRTGVLAHLEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRN 829
Query: 157 LTPYAQRME----RVLRENADSLQASLRPHADELKAKIDQNVEELKGRLTPYADEFKVKI 212
Y + R+ + LQ + + +E++AK D+ +++ K R + K
Sbjct: 830 CAAYLKLRNWQWWRLFTKVKPLLQVTRQE--EEMQAKEDE-LQKTKER--------QQKA 878
Query: 213 DQTVEELRRSLAPYAQDTQEK--LNHQLEGLTFQMKKNAEELKARISASAEELRQRLAPL 270
+ ++EL + ++Q T+EK L QL+ T ++ AEE++ R++A +EL + L +
Sbjct: 879 ENELKELEQK---HSQLTEEKNLLQEQLQAET-ELYAEAEEMRVRLAAKKQELEEILHEM 934
Query: 271 ------AEDVRGNLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQ 324
ED L+ + + + + +L L++ EE R+ + +A ++++E
Sbjct: 935 EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE--EEAARQKLQLEKVTAEAKIKKLED 992
Query: 325 LRQKLGPHAGDVEGHLSFLEKDLRDKVNSFFSTFKEKESQDKTLS---------LPELEQ 375
+ D LS K L ++++ + E+E + K L+ + ELE
Sbjct: 993 EILVM----DDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEV 1048
Query: 376 QQEQQQEQQQEQVQMLAPLE 395
+ +++++ +QE ++ LE
Sbjct: 1049 RLKKEEKSRQELEKLKRKLE 1068
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 66.2 bits (160), Expect = 5e-11
Identities = 95/440 (21%), Positives = 184/440 (41%), Gaps = 75/440 (17%)
Query: 17 GARAEVSADQVATVMWDYFSQLSNNAKEAVEHLQKSELTQQLNA--------LFQDKLGE 68
G + + ++A M D QL + A + LQ ++T + + D+ +
Sbjct: 945 GQQLQAERKKMAQQMLDLEEQLEEE-EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNK 1003
Query: 69 VNTYAGDLQKKLVPFATEL--HERLAKDSEKLKEEIGKELEELRARLLPHANEVSQKIGD 126
++ L++++ T L E AK+ KLK + + EL RL + +K
Sbjct: 1004 LSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRL-----KKEEKSRQ 1058
Query: 127 NLRELQQRLEPYADQLRTQVSTQAEQLRRQLTPYAQRMERVLRENADSLQASLRPHADEL 186
L +L+++LE A Q++ Q+ ++ L + + LQA+L DE+
Sbjct: 1059 ELEKLKRKLEGDASDFHEQIADLQAQIAE--------LKMQLAKKEEELQAALARLDDEI 1110
Query: 187 KAKID--QNVEELKGRLTPY-------------ADEFKVKIDQTVEELRRSLAPYAQDT- 230
K + + + EL+G ++ A++ K + + +E L+ L T
Sbjct: 1111 AQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTA 1170
Query: 231 -QEKLNHQLEGLTFQMKKNAEELKARISASAEELRQRLAPLAEDV----------RGNLR 279
Q++L + E +KK +E A +E+RQ+ A E++ + NL
Sbjct: 1171 TQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD 1230
Query: 280 GNTEGLQKSLAELGGHL------DQQVEEFRRRVEPY----------GENFNKALVQQME 323
N + L+K A+L G L Q+VE ++++E GE L ++
Sbjct: 1231 KNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVH 1290
Query: 324 QLRQKLGPHAG---DVEGHLSFLEKDLRDKVNSFFST--FKEKESQDK---TLSLPELEQ 375
+L+ ++ G + EG L KD+ + T ++E++ K + L +LE+
Sbjct: 1291 KLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEE 1350
Query: 376 QQEQQQEQQQEQVQMLAPLE 395
++ Q+Q E+++ LE
Sbjct: 1351 ERNSLQDQLDEEMEAKQNLE 1370
Score = 60.1 bits (144), Expect = 3e-09
Identities = 85/383 (22%), Positives = 159/383 (41%), Gaps = 75/383 (19%)
Query: 40 NNAKEAVEHLQKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSEKLK 99
N KE + + S+LT++ N L + E YA A E+ RLA ++L+
Sbjct: 880 NELKELEQ--KHSQLTEEKNLLQEQLQAETELYAE---------AEEMRVRLAAKKQELE 928
Query: 100 EEIGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVSTQAEQLRRQLTP 159
E L E+ AR L + Q++ +++ Q++ +QL + + + + ++T
Sbjct: 929 E----ILHEMEAR-LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTA 983
Query: 160 YAQ-------------------RMERVLRENADSLQASLRPHADELKAKIDQNVEELKGR 200
A+ + ++L E L +L +E KAK N+ +LK +
Sbjct: 984 EAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLA--EEEEKAK---NLTKLKNK 1038
Query: 201 LTPYADEFKVKID------QTVEELRRSLAPYAQDTQEK---LNHQLEGLTFQMKKNAEE 251
E +V++ Q +E+L+R L A D E+ L Q+ L Q+ K EE
Sbjct: 1039 HESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE 1098
Query: 252 LKARISASAEELRQRLAPLAEDVRGNLRGNTEGLQKSLAELGGHLDQQVEEF--RRRVEP 309
L+A ++ +E+ Q+ L K + EL GH+ E+ R
Sbjct: 1099 LQAALARLDDEIAQKNNAL----------------KKIRELEGHISDLQEDLDSERAARN 1142
Query: 310 YGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDKVNSFFSTFK---EKESQDK 366
E + L +++E L+ +L + +++LR K + K ++E++
Sbjct: 1143 KAEKQKRDLGEELEALKTELEDTLDS-----TATQQELRAKREQEVTVLKKALDEETRSH 1197
Query: 367 TLSLPELEQQQEQQQEQQQEQVQ 389
+ E+ Q+ Q E+ EQ++
Sbjct: 1198 EAQVQEMRQKHAQAVEELTEQLE 1220
Score = 55.8 bits (133), Expect = 6e-08
Identities = 78/363 (21%), Positives = 156/363 (42%), Gaps = 31/363 (8%)
Query: 42 AKEAVEHLQKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSEKLKEE 101
A+ E L+ E ++ N + + ++ ++ + D+ K + E+ + E EE
Sbjct: 1496 ARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHEL-----EKSKRALETQMEE 1550
Query: 102 IGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVSTQAEQLRRQLTPYA 161
+ +LEEL L + ++ N++ L+ + E Q + QL+RQL Y
Sbjct: 1551 MKTQLEELEDELQA-TEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE 1609
Query: 162 QRMERVLRENADSLQASLRPHAD--ELKAKIDQNV---EELKGRLTPYADEFKVKIDQTV 216
+E ++ A + A + D +L+ + D + EE +L + K + +
Sbjct: 1610 TELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK-DFQREL 1668
Query: 217 EELRRS---LAPYAQDTQEKLNHQLEGLTFQMKKN---AEELKARISASAEELRQRLAPL 270
E+ R S + A++ ++K LE Q++++ AE + + EEL + LA
Sbjct: 1669 EDARASRDEIFATAKENEKKAK-SLEADLMQLQEDLAAAERARKQADLEKEELAEELASS 1727
Query: 271 AEDVRGNLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLG 330
R L+ L+ +A+L ++++EE + +E + KA QQ EQL +L
Sbjct: 1728 LSG-RNALQDEKRRLEARIAQL----EEELEEEQGNMEAMSDRVRKA-TQQAEQLSNELA 1781
Query: 331 PHAGDVEGHLSFLE------KDLRDKVNSFFSTFKEKESQDKTLSLPELEQQQEQQQEQQ 384
+ + S + K+LR K++ K K ++ Q +EQ +++
Sbjct: 1782 TERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEA 1841
Query: 385 QEQ 387
+E+
Sbjct: 1842 REK 1844
Score = 48.9 bits (115), Expect = 8e-06
Identities = 54/214 (25%), Positives = 100/214 (46%), Gaps = 31/214 (14%)
Query: 89 ERLAKDSEKLKEEIGKEL--------------EELRARLLPHANEVSQKIG------DNL 128
ER K ++ KEE+ +EL L AR+ E+ ++ G D +
Sbjct: 1707 ERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRV 1766
Query: 129 RELQQRLEPYADQLRTQVST--QAEQLRRQLTPYAQRMERVLRENADSLQASLRPHADEL 186
R+ Q+ E +++L T+ ST + E R+QL + + L E ++++ + L
Sbjct: 1767 RKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAAL 1826
Query: 187 KAKIDQNVE--ELKGRLTPYADEFKVKIDQTVEEL------RRSLAPYAQDTQEKLNHQL 238
+AKI Q E E + R A + + D+ ++E+ R +A ++ EK N ++
Sbjct: 1827 EAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARV 1886
Query: 239 EGLTFQMKKNAEELKARISASAEELRQRLAPLAE 272
+ L Q+++ AEE RI+A+ +L++ L E
Sbjct: 1887 KQLKRQLEE-AEEESQRINANRRKLQRELDEATE 1919
Score = 47.0 bits (110), Expect = 3e-05
Identities = 78/375 (20%), Positives = 149/375 (39%), Gaps = 74/375 (19%)
Query: 90 RLAKDSEKLKEEIGKELEELRARLLPHANEVSQKIGDNLRELQ------QRLEPYADQLR 143
+L ++ L++++ +E+E + L H + ++ ++ D+ ++LQ + LE + +
Sbjct: 1347 QLEEERNSLQDQLDEEMEA-KQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQ 1405
Query: 144 TQVSTQAEQLRRQLTPY--AQRMERVLRENADSL------QASLRPHADELKAKIDQNVE 195
++ +Q + Y ++ + L++ D L Q L + ++ + K DQ +
Sbjct: 1406 KEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA 1465
Query: 196 ELKGRLTPYADEFKVKIDQTVEELRRSLA-----PYAQDTQEKLNHQLEGLTFQMK---- 246
E K + YADE + E+ ++L+ A + +E+L + L +M+
Sbjct: 1466 EEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVS 1525
Query: 247 ------KNAEEL---KARISASAEELRQRLAPL------AEDVRGNLRGNTEGLQKSLAE 291
KN EL K + EE++ +L L ED + L N + L+
Sbjct: 1526 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1585
Query: 292 LGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLE------- 344
D+Q EE RR+++ + L + +Q R +EG L LE
Sbjct: 1586 DLQARDEQNEEKRRQLQRQLHEYETELEDERKQ-RALAAAAKKKLEGDLKDLELQADSAI 1644
Query: 345 ------------------------KDLRDKVNSFFSTFKEKESQDKTLSLPELEQQQEQQ 380
+D R + F+T KE E + K+L E + Q Q+
Sbjct: 1645 KGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSL---EADLMQLQE 1701
Query: 381 QEQQQEQVQMLAPLE 395
E+ + A LE
Sbjct: 1702 DLAAAERARKQADLE 1716
Score = 40.4 bits (93), Expect = 0.003
Identities = 71/320 (22%), Positives = 141/320 (44%), Gaps = 47/320 (14%)
Query: 102 IGKELEELRARLLPHANEVSQ-KIGDNLRELQQRLEPY----ADQLRTQVSTQAEQLRRQ 156
IG+ R +L H E KI D + Q Y A R Q T + ++R
Sbjct: 770 IGQSKIFFRTGVLAHLEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRN 829
Query: 157 LTPYAQRME----RVLRENADSLQASLRPHADELKAKIDQNVEELKGRLTPYADEFKVKI 212
Y + R+ + LQ + + +E++AK D+ +++ K R + K
Sbjct: 830 CAAYLKLRNWQWWRLFTKVKPLLQVTRQE--EEMQAKEDE-LQKTKER--------QQKA 878
Query: 213 DQTVEELRRSLAPYAQDTQEK--LNHQLEGLTFQMKKNAEELKARISASAEELRQRLAPL 270
+ ++EL + ++Q T+EK L QL+ T ++ AEE++ R++A +EL + L +
Sbjct: 879 ENELKELEQK---HSQLTEEKNLLQEQLQAET-ELYAEAEEMRVRLAAKKQELEEILHEM 934
Query: 271 ------AEDVRGNLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQ 324
ED L+ + + + + +L L++ EE R+ + +A ++++E
Sbjct: 935 EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE--EEAARQKLQLEKVTAEAKIKKLED 992
Query: 325 LRQKLGPHAGDVEGHLSFLEKDLRDKVNSFFSTFKEKESQDKTLS---------LPELEQ 375
+ D LS K L ++++ + E+E + K L+ + ELE
Sbjct: 993 EILVM----DDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEV 1048
Query: 376 QQEQQQEQQQEQVQMLAPLE 395
+ +++++ +QE ++ LE
Sbjct: 1049 RLKKEEKSRQELEKLKRKLE 1068
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 66.2 bits (160), Expect = 5e-11
Identities = 95/440 (21%), Positives = 184/440 (41%), Gaps = 75/440 (17%)
Query: 17 GARAEVSADQVATVMWDYFSQLSNNAKEAVEHLQKSELTQQLNA--------LFQDKLGE 68
G + + ++A M D QL + A + LQ ++T + + D+ +
Sbjct: 938 GQQLQAERKKMAQQMLDLEEQLEEE-EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNK 996
Query: 69 VNTYAGDLQKKLVPFATEL--HERLAKDSEKLKEEIGKELEELRARLLPHANEVSQKIGD 126
++ L++++ T L E AK+ KLK + + EL RL + +K
Sbjct: 997 LSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRL-----KKEEKSRQ 1051
Query: 127 NLRELQQRLEPYADQLRTQVSTQAEQLRRQLTPYAQRMERVLRENADSLQASLRPHADEL 186
L +L+++LE A Q++ Q+ ++ L + + LQA+L DE+
Sbjct: 1052 ELEKLKRKLEGDASDFHEQIADLQAQIAE--------LKMQLAKKEEELQAALARLDDEI 1103
Query: 187 KAKID--QNVEELKGRLTPY-------------ADEFKVKIDQTVEELRRSLAPYAQDT- 230
K + + + EL+G ++ A++ K + + +E L+ L T
Sbjct: 1104 AQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTA 1163
Query: 231 -QEKLNHQLEGLTFQMKKNAEELKARISASAEELRQRLAPLAEDV----------RGNLR 279
Q++L + E +KK +E A +E+RQ+ A E++ + NL
Sbjct: 1164 TQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD 1223
Query: 280 GNTEGLQKSLAELGGHL------DQQVEEFRRRVEPY----------GENFNKALVQQME 323
N + L+K A+L G L Q+VE ++++E GE L ++
Sbjct: 1224 KNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVH 1283
Query: 324 QLRQKLGPHAG---DVEGHLSFLEKDLRDKVNSFFST--FKEKESQDK---TLSLPELEQ 375
+L+ ++ G + EG L KD+ + T ++E++ K + L +LE+
Sbjct: 1284 KLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEE 1343
Query: 376 QQEQQQEQQQEQVQMLAPLE 395
++ Q+Q E+++ LE
Sbjct: 1344 ERNSLQDQLDEEMEAKQNLE 1363
Score = 60.1 bits (144), Expect = 3e-09
Identities = 85/383 (22%), Positives = 159/383 (41%), Gaps = 75/383 (19%)
Query: 40 NNAKEAVEHLQKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSEKLK 99
N KE + + S+LT++ N L + E YA A E+ RLA ++L+
Sbjct: 873 NELKELEQ--KHSQLTEEKNLLQEQLQAETELYAE---------AEEMRVRLAAKKQELE 921
Query: 100 EEIGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVSTQAEQLRRQLTP 159
E L E+ AR L + Q++ +++ Q++ +QL + + + + ++T
Sbjct: 922 E----ILHEMEAR-LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTA 976
Query: 160 YAQ-------------------RMERVLRENADSLQASLRPHADELKAKIDQNVEELKGR 200
A+ + ++L E L +L +E KAK N+ +LK +
Sbjct: 977 EAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLA--EEEEKAK---NLTKLKNK 1031
Query: 201 LTPYADEFKVKID------QTVEELRRSLAPYAQDTQEK---LNHQLEGLTFQMKKNAEE 251
E +V++ Q +E+L+R L A D E+ L Q+ L Q+ K EE
Sbjct: 1032 HESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE 1091
Query: 252 LKARISASAEELRQRLAPLAEDVRGNLRGNTEGLQKSLAELGGHLDQQVEEF--RRRVEP 309
L+A ++ +E+ Q+ L K + EL GH+ E+ R
Sbjct: 1092 LQAALARLDDEIAQKNNAL----------------KKIRELEGHISDLQEDLDSERAARN 1135
Query: 310 YGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDKVNSFFSTFK---EKESQDK 366
E + L +++E L+ +L + +++LR K + K ++E++
Sbjct: 1136 KAEKQKRDLGEELEALKTELEDTLDS-----TATQQELRAKREQEVTVLKKALDEETRSH 1190
Query: 367 TLSLPELEQQQEQQQEQQQEQVQ 389
+ E+ Q+ Q E+ EQ++
Sbjct: 1191 EAQVQEMRQKHAQAVEELTEQLE 1213
Score = 55.8 bits (133), Expect = 6e-08
Identities = 78/363 (21%), Positives = 156/363 (42%), Gaps = 31/363 (8%)
Query: 42 AKEAVEHLQKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSEKLKEE 101
A+ E L+ E ++ N + + ++ ++ + D+ K + E+ + E EE
Sbjct: 1489 ARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHEL-----EKSKRALETQMEE 1543
Query: 102 IGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVSTQAEQLRRQLTPYA 161
+ +LEEL L + ++ N++ L+ + E Q + QL+RQL Y
Sbjct: 1544 MKTQLEELEDELQA-TEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE 1602
Query: 162 QRMERVLRENADSLQASLRPHAD--ELKAKIDQNV---EELKGRLTPYADEFKVKIDQTV 216
+E ++ A + A + D +L+ + D + EE +L + K + +
Sbjct: 1603 TELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK-DFQREL 1661
Query: 217 EELRRS---LAPYAQDTQEKLNHQLEGLTFQMKKN---AEELKARISASAEELRQRLAPL 270
E+ R S + A++ ++K LE Q++++ AE + + EEL + LA
Sbjct: 1662 EDARASRDEIFATAKENEKKAK-SLEADLMQLQEDLAAAERARKQADLEKEELAEELASS 1720
Query: 271 AEDVRGNLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLG 330
R L+ L+ +A+L ++++EE + +E + KA QQ EQL +L
Sbjct: 1721 LSG-RNALQDEKRRLEARIAQL----EEELEEEQGNMEAMSDRVRKA-TQQAEQLSNELA 1774
Query: 331 PHAGDVEGHLSFLE------KDLRDKVNSFFSTFKEKESQDKTLSLPELEQQQEQQQEQQ 384
+ + S + K+LR K++ K K ++ Q +EQ +++
Sbjct: 1775 TERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEA 1834
Query: 385 QEQ 387
+E+
Sbjct: 1835 REK 1837
Score = 48.9 bits (115), Expect = 8e-06
Identities = 54/214 (25%), Positives = 100/214 (46%), Gaps = 31/214 (14%)
Query: 89 ERLAKDSEKLKEEIGKEL--------------EELRARLLPHANEVSQKIG------DNL 128
ER K ++ KEE+ +EL L AR+ E+ ++ G D +
Sbjct: 1700 ERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRV 1759
Query: 129 RELQQRLEPYADQLRTQVST--QAEQLRRQLTPYAQRMERVLRENADSLQASLRPHADEL 186
R+ Q+ E +++L T+ ST + E R+QL + + L E ++++ + L
Sbjct: 1760 RKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAAL 1819
Query: 187 KAKIDQNVE--ELKGRLTPYADEFKVKIDQTVEEL------RRSLAPYAQDTQEKLNHQL 238
+AKI Q E E + R A + + D+ ++E+ R +A ++ EK N ++
Sbjct: 1820 EAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARV 1879
Query: 239 EGLTFQMKKNAEELKARISASAEELRQRLAPLAE 272
+ L Q+++ AEE RI+A+ +L++ L E
Sbjct: 1880 KQLKRQLEE-AEEESQRINANRRKLQRELDEATE 1912
Score = 47.0 bits (110), Expect = 3e-05
Identities = 78/375 (20%), Positives = 149/375 (39%), Gaps = 74/375 (19%)
Query: 90 RLAKDSEKLKEEIGKELEELRARLLPHANEVSQKIGDNLRELQ------QRLEPYADQLR 143
+L ++ L++++ +E+E + L H + ++ ++ D+ ++LQ + LE + +
Sbjct: 1340 QLEEERNSLQDQLDEEMEA-KQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQ 1398
Query: 144 TQVSTQAEQLRRQLTPY--AQRMERVLRENADSL------QASLRPHADELKAKIDQNVE 195
++ +Q + Y ++ + L++ D L Q L + ++ + K DQ +
Sbjct: 1399 KEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA 1458
Query: 196 ELKGRLTPYADEFKVKIDQTVEELRRSLA-----PYAQDTQEKLNHQLEGLTFQMK---- 246
E K + YADE + E+ ++L+ A + +E+L + L +M+
Sbjct: 1459 EEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVS 1518
Query: 247 ------KNAEEL---KARISASAEELRQRLAPL------AEDVRGNLRGNTEGLQKSLAE 291
KN EL K + EE++ +L L ED + L N + L+
Sbjct: 1519 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1578
Query: 292 LGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLE------- 344
D+Q EE RR+++ + L + +Q R +EG L LE
Sbjct: 1579 DLQARDEQNEEKRRQLQRQLHEYETELEDERKQ-RALAAAAKKKLEGDLKDLELQADSAI 1637
Query: 345 ------------------------KDLRDKVNSFFSTFKEKESQDKTLSLPELEQQQEQQ 380
+D R + F+T KE E + K+L E + Q Q+
Sbjct: 1638 KGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSL---EADLMQLQE 1694
Query: 381 QEQQQEQVQMLAPLE 395
E+ + A LE
Sbjct: 1695 DLAAAERARKQADLE 1709
Score = 40.4 bits (93), Expect = 0.003
Identities = 71/320 (22%), Positives = 141/320 (44%), Gaps = 47/320 (14%)
Query: 102 IGKELEELRARLLPHANEVSQ-KIGDNLRELQQRLEPY----ADQLRTQVSTQAEQLRRQ 156
IG+ R +L H E KI D + Q Y A R Q T + ++R
Sbjct: 763 IGQSKIFFRTGVLAHLEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRN 822
Query: 157 LTPYAQRME----RVLRENADSLQASLRPHADELKAKIDQNVEELKGRLTPYADEFKVKI 212
Y + R+ + LQ + + +E++AK D+ +++ K R + K
Sbjct: 823 CAAYLKLRNWQWWRLFTKVKPLLQVTRQE--EEMQAKEDE-LQKTKER--------QQKA 871
Query: 213 DQTVEELRRSLAPYAQDTQEK--LNHQLEGLTFQMKKNAEELKARISASAEELRQRLAPL 270
+ ++EL + ++Q T+EK L QL+ T ++ AEE++ R++A +EL + L +
Sbjct: 872 ENELKELEQK---HSQLTEEKNLLQEQLQAET-ELYAEAEEMRVRLAAKKQELEEILHEM 927
Query: 271 ------AEDVRGNLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQ 324
ED L+ + + + + +L L++ EE R+ + +A ++++E
Sbjct: 928 EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE--EEAARQKLQLEKVTAEAKIKKLED 985
Query: 325 LRQKLGPHAGDVEGHLSFLEKDLRDKVNSFFSTFKEKESQDKTLS---------LPELEQ 375
+ D LS K L ++++ + E+E + K L+ + ELE
Sbjct: 986 EILVM----DDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEV 1041
Query: 376 QQEQQQEQQQEQVQMLAPLE 395
+ +++++ +QE ++ LE
Sbjct: 1042 RLKKEEKSRQELEKLKRKLE 1061
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 65.9 bits (159), Expect = 6e-11
Identities = 85/399 (21%), Positives = 173/399 (43%), Gaps = 56/399 (14%)
Query: 37 QLSNNAKEAVEHLQKS-----ELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERL 91
QL A++ + L S EL Q L+A+ K + + Y +L K+ + EL+
Sbjct: 143 QLEGEARDLISRLHDSWKFAGELEQALSAVATQKK-KADRYIEELTKERDALSLELYRNT 201
Query: 92 AKDSEKLKEEIGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQL-RTQVSTQA 150
D E+LKE+ K E+L+ +I N++EL+++LE L + Q+ +A
Sbjct: 202 ITD-EELKEKNAKLQEKLQL-----VESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEA 255
Query: 151 EQLRRQLTPYAQRMERVLRENADSLQASLRPHADELKAKIDQNVEELKGRLTPYADEFKV 210
+ L ++L + +++ + EN L L +E + ++ ++E + ++ ++ +
Sbjct: 256 DHLGKELQSVSAKLQAQVEEN--ELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIRE 313
Query: 211 KIDQT---------VEELRRSLAPYAQDTQEKLN------HQLEGLTFQMKKNAEELKAR 255
+ ++ EE R + +EK+ H+ E + Q +K EE K R
Sbjct: 314 QEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIR 373
Query: 256 ISASAEELRQRLAPLAEDVRGN---LRGNTEGLQKSLAELGGH----------LDQQVEE 302
+E ++ E +R +R E +Q+ ++G + +Q E+
Sbjct: 374 EQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEK 433
Query: 303 FRRRVEPYGENFNKALVQQ---------MEQLRQKLGPHAGDV---EGHLSFLEKDLRDK 350
RR+ E E K Q+ M++ +K+G G + E + E+ +R +
Sbjct: 434 MRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQ 493
Query: 351 VNSFFSTFKE-KESQDKTLSLPELEQQQEQQQEQQQEQV 388
K+ +E ++K E+ Q+QE++ +Q+E++
Sbjct: 494 EEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKM 532
Score = 56.6 bits (135), Expect = 4e-08
Identities = 78/398 (19%), Positives = 176/398 (44%), Gaps = 53/398 (13%)
Query: 34 YFSQLSNNAKEAVEHLQKSELT----QQLNALFQDKLGEVNTYAGDLQKKLVPFATELHE 89
Y +L+ L ++ +T ++ NA Q+KL V + ++Q + +L
Sbjct: 182 YIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLER 241
Query: 90 -RLAKDSEKLKEE---IGKELEELRARLLPHA------NEVSQKIGDNLRELQQRLEPYA 139
+L ++L+ E +GKEL+ + A+L N ++Q+ + + +++++
Sbjct: 242 AKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQERE 301
Query: 140 DQLRTQ---VSTQAEQLRRQLTPYAQRMERVLR---------ENADSLQASLRPHADELK 187
++++ Q + Q E++RRQ ++ E++ R E L+ + ++++
Sbjct: 302 EKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQ-EKIR 360
Query: 188 AKIDQNVEELKGRLTPYADEFKVKIDQTVEELR------RSLAPYAQDTQEKLNHQLEGL 241
+ ++ EE K R E + K+ + E++R R Q+ +EK+ Q E +
Sbjct: 361 EQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKM 420
Query: 242 TFQMKKNAEELKARISASAEELRQRLAPLAEDVRGNLRGNTEGLQKSLAELG-------- 293
++ ++ +E + ++ E++R++ + E +R E +Q+ ++G
Sbjct: 421 -WEQEEEMQEQEEKMRRQEEKIREQEKKIREQEE-KIREQEEMMQEQEEKMGEQEGKMCE 478
Query: 294 --GHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDKV 351
+ +Q E+ RR+ E E K + +Q E++R++ E EK +
Sbjct: 479 QEAKMQEQEEKMRRQEEKIREQ-EKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEE 537
Query: 352 NSFFSTFKEKESQDKTLSLPELEQQQEQQQEQQQEQVQ 389
K +E ++K E ++QE + QQ+E++Q
Sbjct: 538 -------KMQEQEEKMRRQEEKMREQEVRLRQQEEKMQ 568
Score = 52.4 bits (124), Expect = 7e-07
Identities = 67/326 (20%), Positives = 154/326 (47%), Gaps = 58/326 (17%)
Query: 72 YAGDLQKKLVPFATELHERLAKDSEKLKEEIGKELEELRARLLPHANEVS-QKIGDNLRE 130
+AG+L++ L AT+ K +++ EE+ KE + L L + N ++ +++ + +
Sbjct: 161 FAGELEQALSAVATQ-----KKKADRYIEELTKERDALSLEL--YRNTITDEELKEKNAK 213
Query: 131 LQQRLEPYADQLRTQVSTQAEQLRRQLTPYAQRM-ERVLRENADSLQASLRPHADELKAK 189
LQ++L+ + ++++ ++L+R+L + ++ L+ AD L L+ + +L+A+
Sbjct: 214 LQEKLQ-LVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQ 272
Query: 190 IDQNVEELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQ--MKK 247
+++N EL RL +E + ++ ++E + Q+ +EK+ Q E + Q M
Sbjct: 273 VEEN--ELWNRLNQQQEEKMWRQEEKIQEREEKI----QEQEEKIREQEEKMRRQEEMMW 326
Query: 248 NAEELKARISASAEELRQRLAPLAEDV--RGNLRGNTEGLQKSLAELGGHLDQQVEEFRR 305
EE R E +++ L E + + +R E Q+ ++++ E +
Sbjct: 327 EKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQE---------EEKIREQEK 377
Query: 306 RVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDKVNSFFSTFKEKESQD 365
R E + + +Q E++R++ E+ +R++ E+ Q+
Sbjct: 378 RQEQEAKMW-----RQEEKIREQ---------------EEKIREQ---------EEMMQE 408
Query: 366 KTLSLPELEQQQEQQQEQQQEQVQML 391
+ + E E++ +Q+E+ QEQ + +
Sbjct: 409 QEEKMGEQEEKMWEQEEEMQEQEEKM 434
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 65.1 bits (157), Expect = 1e-10
Identities = 84/353 (23%), Positives = 146/353 (41%), Gaps = 58/353 (16%)
Query: 77 QKKLVPFATELHERLAKDSEKLKEEIGKELEELRARLLPHANEVSQKIGDNLRELQQRLE 136
QK+ E H++ A+ + + K ++ +EL LR + L + + + L+ L+
Sbjct: 2159 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ-LEETDHQKNLLDEELQRLKAEAT 2217
Query: 137 PYADQLRTQVSTQAEQLRRQLTPYAQRMERVLREN-------ADSLQASLRPHADELKAK 189
A Q R+QV + +R Q+ ++ R+ EN D+ Q L+ A+++K
Sbjct: 2218 EAARQ-RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK-- 2274
Query: 190 IDQNVEELKGRLTPYADEFKVKIDQTVEE--------LRRSLAPYAQDTQEKLNHQLEG- 240
V E RL+ A E ++ Q EE + L Q QE + E
Sbjct: 2275 ---QVAEEAARLSVAAQE-AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE 2330
Query: 241 LTFQMKKNAEELKARISASAEELRQRLAPLAEDVRGNLR----------GNTEGLQKSLA 290
L Q K+ A+E R+ E++ Q+LA + + L E L+ +A
Sbjct: 2331 LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2390
Query: 291 ELG---GHLDQQVEEFRRRVEPYGENFNK---------ALVQQMEQLRQKLGPHAGDVEG 338
E+ ++ + FR++ E GE ++ LVQ +E RQ+ A +
Sbjct: 2391 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2450
Query: 339 HLSFLEKDLRDKVNSFFSTFKEKESQDKTLSLPELEQQQEQQQEQQQEQVQML 391
++ LE++ KEK Q+ L + E+ Q QQEQ ++ Q L
Sbjct: 2451 AIAELERE------------KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL 2491
Score = 61.6 bits (148), Expect = 1e-09
Identities = 94/406 (23%), Positives = 174/406 (42%), Gaps = 63/406 (15%)
Query: 36 SQLSNNAKEAVEHL-QKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKD 94
+++ + K A + L QK+++ Q+L L + +L E + L ++L E E A+
Sbjct: 2165 AEMEKHKKFAEQTLRQKAQVEQELTTL-RLQLEETDHQKNLLDEELQRLKAEATEA-ARQ 2222
Query: 95 SEKLKEEIG------KELEELRARLLPHANEVSQKIGDN----LRELQQRLEPYADQL-R 143
+++EE+ +EL +L+AR+ + + DN L+E ++++ A++ R
Sbjct: 2223 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR 2282
Query: 144 TQVSTQAEQLRRQLTPYAQRMERVLRENADSLQASLRPHADELKAKIDQNVEELKGRLTP 203
V+ Q RQL +R L E + A LKA+ EL +
Sbjct: 2283 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA-----ELLQQQKE 2337
Query: 204 YADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELKARIS------ 257
A E ++ + E++ + LA Q Q L + + +M AE LK R++
Sbjct: 2338 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR-QLEMSAEAERLKLRVAEMSRAQ 2396
Query: 258 ASAEELRQRLAPLAEDVRGNLRG------------------------NTEGLQKSLAELG 293
A AEE QR AE++ L + E L++++AEL
Sbjct: 2397 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2456
Query: 294 GH---LDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDK 350
L Q+ + + + E + L+Q+ + L+Q + F+E++ + K
Sbjct: 2457 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE-KAK 2515
Query: 351 VNSFFSTFKEKESQDKTLSLPEL-EQQQEQQQEQQQEQVQMLAPLE 395
+ F QD+ +L E+QQ QQQ+ +QE+ +++A +E
Sbjct: 2516 LEQLF--------QDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2553
Score = 52.8 bits (125), Expect = 5e-07
Identities = 87/389 (22%), Positives = 173/389 (44%), Gaps = 54/389 (13%)
Query: 19 RAEVSADQVATVMWD------YFSQLSNNAKEAVEHLQKSELTQQ----LNALFQDKLGE 68
+A + A+ A ++ D + + + K+ E + + Q L L ++ L +
Sbjct: 2244 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2303
Query: 69 VNTYAGDLQKKLVPFATELHERLAKDSEKLKEEIGKELEELRARLLPHANE-VSQKIGDN 127
A + K+ + E RL ++E L+++ KEL + +AR L E ++Q++ +
Sbjct: 2304 QRALAEKMLKEKMQAVQEA-TRLKAEAELLQQQ--KELAQEQARRLQEDKEQMAQQLAEE 2360
Query: 128 LRELQQRLEPYADQLRTQVSTQAEQLRRQLTPYAQRMERVLRENADSLQASLRPHADELK 187
+ Q+ LE Q + ++S +AE+L+ ++ ++ R A+ R A+E+
Sbjct: 2361 TQGFQRTLEAER-QRQLEMSAEAERLKLRVAEMSRAQAR-----AEEDAQRFRKQAEEIG 2414
Query: 188 AKIDQN--VEELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQM 245
K+ + + K L + + + D E LR ++A ++ +EKL Q E Q+
Sbjct: 2415 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE-KEKL--QQEAKLLQL 2471
Query: 246 KKNAEELKARISASAEELRQRLAPLAEDV---RGNLRGNTEGLQKSLAELGGHLDQQVEE 302
K +EE++ + E+L Q L + + +L +++ A+L +V +
Sbjct: 2472 K--SEEMQ---TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAK 2526
Query: 303 FRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDKVNSFFSTFKEKE 362
++ E + QQMEQ RQ+L ++ +E+ R + + E+
Sbjct: 2527 AQQLREE-----QQRQQQQMEQERQRL----------VASMEEARRRQHEA------EEG 2565
Query: 363 SQDKTLSLPELEQQQEQQQEQQQEQVQML 391
+ K L +LEQQ+ QQ+E E+ Q L
Sbjct: 2566 VRRKQEELQQLEQQRRQQEELLAEENQRL 2594
Score = 52.4 bits (124), Expect = 7e-07
Identities = 92/396 (23%), Positives = 166/396 (41%), Gaps = 55/396 (13%)
Query: 37 QLSNNAKEAVEHLQKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSE 96
+L+ E L + Q+L A + T G+ Q++L+ +R A +
Sbjct: 1688 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1747
Query: 97 KLKEEIGKELEELRAR---LLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVSTQAEQL 153
+ ++E+ EL ++RA LL ++ + +QRLE A + R +++ +A +L
Sbjct: 1748 QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR-ELAEEAARL 1806
Query: 154 RRQLTPYAQRMERVLRENADSLQASLRP----------HADELKAKIDQNVEELKG---- 199
R L A+R ++ E+A +A A LK + + ++E +
Sbjct: 1807 RA-LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENER 1865
Query: 200 -------------RLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQMK 246
RL A + K I++ + +LR+ A D++ + L T + +
Sbjct: 1866 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK-----ASDSELERQKGLVEDTLRQR 1920
Query: 247 KNAEELKARISASAEELRQRLAPLAEDVRGNLRGNTEGL--QKSLAELGGHLDQQV--EE 302
+ EE + AS E+ A L ++ G +R N E K AEL +Q+ EE
Sbjct: 1921 RQVEEEILALKASFEKAAAGKAELELEL-GRIRSNAEDTLRSKEQAELEAARQRQLAAEE 1979
Query: 303 FRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLE--KDLRDKVNSFFS---- 356
RRR E E K+L + E RQ+ +VE + +E + LR++ +
Sbjct: 1980 ERRRREAE-ERVQKSLAAEEEAARQRKAA-LEEVERLKAKVEEARRLRERAEQESARQLQ 2037
Query: 357 -----TFKEKESQDKTLSLPELEQQQEQQQEQQQEQ 387
K ++++K + +++QE QQ QQEQ
Sbjct: 2038 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2073
Score = 50.4 bits (119), Expect = 3e-06
Identities = 81/355 (22%), Positives = 145/355 (40%), Gaps = 43/355 (12%)
Query: 2 FLKAVVLTLALVAVAGARAEVSADQVATVMWDYFSQLSNNAKEAVEHLQKSELTQQLNAL 61
FL+ + VA AR V+A + A + QL+ L + L +++ A+
Sbjct: 2265 FLQEEAEKMKQVAEEAARLSVAAQEAARLR-----QLAEEDLAQQRALAEKMLKEKMQAV 2319
Query: 62 FQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSEKLKEEIGKE-------LEELRARLL 114
+ + QK+L A E RL +D E++ +++ +E LE R R L
Sbjct: 2320 QEATRLKAEAELLQQQKEL---AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2376
Query: 115 PHANEVSQ---KIGDNLRELQQRLEPYADQLRTQVSTQAEQLRR------QLTPYAQRME 165
+ E + ++ + R Q R E A + R Q E+L R + Q +E
Sbjct: 2377 EMSAEAERLKLRVAEMSRA-QARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2435
Query: 166 RVLRENADSLQASLRPHADELKAKIDQNVEELKGRLTPYADEFKVKIDQTVEELRRSLAP 225
+ R+ +D LR EL+ + ++ +E K + V+ +Q ++E +
Sbjct: 2436 -IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2494
Query: 226 YAQDTQEKLNHQ---------LEGLTFQMKKNAEELKA---RISASAEELRQRLAPLAED 273
+ + L + LE L A++L+ R E+ RQRL E+
Sbjct: 2495 FLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE 2554
Query: 274 VRGNLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQK 328
R EG+++ EL QQ+E+ RR+ E N+ L +Q++ L ++
Sbjct: 2555 ARRRQHEAEEGVRRKQEEL-----QQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2604
Score = 48.9 bits (115), Expect = 8e-06
Identities = 67/312 (21%), Positives = 137/312 (43%), Gaps = 59/312 (18%)
Query: 89 ERLAKDSEKLKEEIGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVST 148
++ A++ E+L E + LE+ R HA +Q + +ELQQR++ + R + +
Sbjct: 1353 QQRAEERERLAE-VEAALEKQRQLAEAHAQAKAQAERE-AKELQQRMQEEVVR-REEAAV 1409
Query: 149 QAEQLRRQLTPYAQRMERVLRENADS-LQASLRPH--ADELKAKIDQNV----------E 195
A+Q +R + Q+ LR+++++ +QA R A+ + +I++ + E
Sbjct: 1410 DAQQQKRSIQEELQQ----LRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE 1465
Query: 196 ELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAE-ELKA 254
+G + + ++ + R+ AQ+ E+L Q++ + Q K+ AE EL +
Sbjct: 1466 RQRGGAEGELQALRARAEEAEAQKRQ-----AQEEAERLRRQVQDES-QRKRQAEVELAS 1519
Query: 255 RISASAEELRQRLAPLAEDVRGNLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENF 314
R+ A AE R++ Q++L Q +EE R + E
Sbjct: 1520 RVKAEAEAAREK-------------------QRAL--------QALEELRLQAEEAERRL 1552
Query: 315 NKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDKVNSFFSTFKEKESQDKTLSLPELE 374
+A V++ Q++ L E L +K E+ Q++ +++ +L
Sbjct: 1553 RQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL-----ERSLQEEHVAVAQLR 1607
Query: 375 QQQEQQQEQQQE 386
++ E++ +QQ E
Sbjct: 1608 EEAERRAQQQAE 1619
Score = 48.1 bits (113), Expect = 1e-05
Identities = 86/364 (23%), Positives = 147/364 (40%), Gaps = 31/364 (8%)
Query: 44 EAVEHLQKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSE--KLKEE 101
EA + +E +L AL ++ + D ++ L E+LA E +LK E
Sbjct: 1792 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE 1851
Query: 102 IGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVSTQAEQLRRQLTPYA 161
L+E A NE +++ ++ ++RLE A Q + + + QLR+
Sbjct: 1852 AEIALKEKEAE-----NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1906
Query: 162 QR----MERVLRENADSLQASLRPHADELKAKIDQNVEELK-GRLTPYADEFKVKIDQTV 216
+R +E LR+ + L A KA + EL+ GR+ A++ +Q
Sbjct: 1907 ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 1966
Query: 217 EELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELKARISASAEELRQRLAPLAEDVRG 276
E R A++ + + + Q AEE AR +A E +RL E+ R
Sbjct: 1967 LEAARQRQLAAEEERRRREAEER---VQKSLAAEEEAARQRKAALEEVERLKAKVEEAR- 2022
Query: 277 NLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENF-----NKALVQQMEQLRQKLGP 331
LR E Q+S +L L Q+ + R + E F + L Q ++Q + L
Sbjct: 2023 RLRERAE--QESARQL--QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2078
Query: 332 HAGDVEGHLSFLEKDLRDKVNSFFSTFKEKESQDKTLSLPELEQQQEQQQEQQQEQVQML 391
G+ E E+ +V + E+E+ + E E+ ++ +EQ Q + Q
Sbjct: 2079 LRGEAEAARRAAEEAEEARVQA------EREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2132
Query: 392 APLE 395
A E
Sbjct: 2133 AAAE 2136
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 65.1 bits (157), Expect = 1e-10
Identities = 84/353 (23%), Positives = 146/353 (41%), Gaps = 58/353 (16%)
Query: 77 QKKLVPFATELHERLAKDSEKLKEEIGKELEELRARLLPHANEVSQKIGDNLRELQQRLE 136
QK+ E H++ A+ + + K ++ +EL LR + L + + + L+ L+
Sbjct: 2163 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ-LEETDHQKNLLDEELQRLKAEAT 2221
Query: 137 PYADQLRTQVSTQAEQLRRQLTPYAQRMERVLREN-------ADSLQASLRPHADELKAK 189
A Q R+QV + +R Q+ ++ R+ EN D+ Q L+ A+++K
Sbjct: 2222 EAARQ-RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK-- 2278
Query: 190 IDQNVEELKGRLTPYADEFKVKIDQTVEE--------LRRSLAPYAQDTQEKLNHQLEG- 240
V E RL+ A E ++ Q EE + L Q QE + E
Sbjct: 2279 ---QVAEEAARLSVAAQE-AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE 2334
Query: 241 LTFQMKKNAEELKARISASAEELRQRLAPLAEDVRGNLR----------GNTEGLQKSLA 290
L Q K+ A+E R+ E++ Q+LA + + L E L+ +A
Sbjct: 2335 LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2394
Query: 291 ELG---GHLDQQVEEFRRRVEPYGENFNK---------ALVQQMEQLRQKLGPHAGDVEG 338
E+ ++ + FR++ E GE ++ LVQ +E RQ+ A +
Sbjct: 2395 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2454
Query: 339 HLSFLEKDLRDKVNSFFSTFKEKESQDKTLSLPELEQQQEQQQEQQQEQVQML 391
++ LE++ KEK Q+ L + E+ Q QQEQ ++ Q L
Sbjct: 2455 AIAELERE------------KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL 2495
Score = 61.6 bits (148), Expect = 1e-09
Identities = 94/406 (23%), Positives = 174/406 (42%), Gaps = 63/406 (15%)
Query: 36 SQLSNNAKEAVEHL-QKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKD 94
+++ + K A + L QK+++ Q+L L + +L E + L ++L E E A+
Sbjct: 2169 AEMEKHKKFAEQTLRQKAQVEQELTTL-RLQLEETDHQKNLLDEELQRLKAEATEA-ARQ 2226
Query: 95 SEKLKEEIG------KELEELRARLLPHANEVSQKIGDN----LRELQQRLEPYADQL-R 143
+++EE+ +EL +L+AR+ + + DN L+E ++++ A++ R
Sbjct: 2227 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR 2286
Query: 144 TQVSTQAEQLRRQLTPYAQRMERVLRENADSLQASLRPHADELKAKIDQNVEELKGRLTP 203
V+ Q RQL +R L E + A LKA+ EL +
Sbjct: 2287 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA-----ELLQQQKE 2341
Query: 204 YADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELKARIS------ 257
A E ++ + E++ + LA Q Q L + + +M AE LK R++
Sbjct: 2342 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR-QLEMSAEAERLKLRVAEMSRAQ 2400
Query: 258 ASAEELRQRLAPLAEDVRGNLRG------------------------NTEGLQKSLAELG 293
A AEE QR AE++ L + E L++++AEL
Sbjct: 2401 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2460
Query: 294 GH---LDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDK 350
L Q+ + + + E + L+Q+ + L+Q + F+E++ + K
Sbjct: 2461 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE-KAK 2519
Query: 351 VNSFFSTFKEKESQDKTLSLPEL-EQQQEQQQEQQQEQVQMLAPLE 395
+ F QD+ +L E+QQ QQQ+ +QE+ +++A +E
Sbjct: 2520 LEQLF--------QDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2557
Score = 52.8 bits (125), Expect = 5e-07
Identities = 87/389 (22%), Positives = 173/389 (44%), Gaps = 54/389 (13%)
Query: 19 RAEVSADQVATVMWD------YFSQLSNNAKEAVEHLQKSELTQQ----LNALFQDKLGE 68
+A + A+ A ++ D + + + K+ E + + Q L L ++ L +
Sbjct: 2248 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2307
Query: 69 VNTYAGDLQKKLVPFATELHERLAKDSEKLKEEIGKELEELRARLLPHANE-VSQKIGDN 127
A + K+ + E RL ++E L+++ KEL + +AR L E ++Q++ +
Sbjct: 2308 QRALAEKMLKEKMQAVQEA-TRLKAEAELLQQQ--KELAQEQARRLQEDKEQMAQQLAEE 2364
Query: 128 LRELQQRLEPYADQLRTQVSTQAEQLRRQLTPYAQRMERVLRENADSLQASLRPHADELK 187
+ Q+ LE Q + ++S +AE+L+ ++ ++ R A+ R A+E+
Sbjct: 2365 TQGFQRTLEAER-QRQLEMSAEAERLKLRVAEMSRAQAR-----AEEDAQRFRKQAEEIG 2418
Query: 188 AKIDQN--VEELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQM 245
K+ + + K L + + + D E LR ++A ++ +EKL Q E Q+
Sbjct: 2419 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE-KEKL--QQEAKLLQL 2475
Query: 246 KKNAEELKARISASAEELRQRLAPLAEDV---RGNLRGNTEGLQKSLAELGGHLDQQVEE 302
K +EE++ + E+L Q L + + +L +++ A+L +V +
Sbjct: 2476 K--SEEMQ---TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAK 2530
Query: 303 FRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDKVNSFFSTFKEKE 362
++ E + QQMEQ RQ+L ++ +E+ R + + E+
Sbjct: 2531 AQQLREE-----QQRQQQQMEQERQRL----------VASMEEARRRQHEA------EEG 2569
Query: 363 SQDKTLSLPELEQQQEQQQEQQQEQVQML 391
+ K L +LEQQ+ QQ+E E+ Q L
Sbjct: 2570 VRRKQEELQQLEQQRRQQEELLAEENQRL 2598
Score = 52.4 bits (124), Expect = 7e-07
Identities = 92/396 (23%), Positives = 166/396 (41%), Gaps = 55/396 (13%)
Query: 37 QLSNNAKEAVEHLQKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSE 96
+L+ E L + Q+L A + T G+ Q++L+ +R A +
Sbjct: 1692 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1751
Query: 97 KLKEEIGKELEELRAR---LLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVSTQAEQL 153
+ ++E+ EL ++RA LL ++ + +QRLE A + R +++ +A +L
Sbjct: 1752 QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR-ELAEEAARL 1810
Query: 154 RRQLTPYAQRMERVLRENADSLQASLRP----------HADELKAKIDQNVEELKG---- 199
R L A+R ++ E+A +A A LK + + ++E +
Sbjct: 1811 RA-LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENER 1869
Query: 200 -------------RLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQMK 246
RL A + K I++ + +LR+ A D++ + L T + +
Sbjct: 1870 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK-----ASDSELERQKGLVEDTLRQR 1924
Query: 247 KNAEELKARISASAEELRQRLAPLAEDVRGNLRGNTEGL--QKSLAELGGHLDQQV--EE 302
+ EE + AS E+ A L ++ G +R N E K AEL +Q+ EE
Sbjct: 1925 RQVEEEILALKASFEKAAAGKAELELEL-GRIRSNAEDTLRSKEQAELEAARQRQLAAEE 1983
Query: 303 FRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLE--KDLRDKVNSFFS---- 356
RRR E E K+L + E RQ+ +VE + +E + LR++ +
Sbjct: 1984 ERRRREAE-ERVQKSLAAEEEAARQRKAA-LEEVERLKAKVEEARRLRERAEQESARQLQ 2041
Query: 357 -----TFKEKESQDKTLSLPELEQQQEQQQEQQQEQ 387
K ++++K + +++QE QQ QQEQ
Sbjct: 2042 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2077
Score = 50.4 bits (119), Expect = 3e-06
Identities = 81/355 (22%), Positives = 145/355 (40%), Gaps = 43/355 (12%)
Query: 2 FLKAVVLTLALVAVAGARAEVSADQVATVMWDYFSQLSNNAKEAVEHLQKSELTQQLNAL 61
FL+ + VA AR V+A + A + QL+ L + L +++ A+
Sbjct: 2269 FLQEEAEKMKQVAEEAARLSVAAQEAARLR-----QLAEEDLAQQRALAEKMLKEKMQAV 2323
Query: 62 FQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSEKLKEEIGKE-------LEELRARLL 114
+ + QK+L A E RL +D E++ +++ +E LE R R L
Sbjct: 2324 QEATRLKAEAELLQQQKEL---AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2380
Query: 115 PHANEVSQ---KIGDNLRELQQRLEPYADQLRTQVSTQAEQLRR------QLTPYAQRME 165
+ E + ++ + R Q R E A + R Q E+L R + Q +E
Sbjct: 2381 EMSAEAERLKLRVAEMSRA-QARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2439
Query: 166 RVLRENADSLQASLRPHADELKAKIDQNVEELKGRLTPYADEFKVKIDQTVEELRRSLAP 225
+ R+ +D LR EL+ + ++ +E K + V+ +Q ++E +
Sbjct: 2440 -IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2498
Query: 226 YAQDTQEKLNHQ---------LEGLTFQMKKNAEELKA---RISASAEELRQRLAPLAED 273
+ + L + LE L A++L+ R E+ RQRL E+
Sbjct: 2499 FLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE 2558
Query: 274 VRGNLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQK 328
R EG+++ EL QQ+E+ RR+ E N+ L +Q++ L ++
Sbjct: 2559 ARRRQHEAEEGVRRKQEEL-----QQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2608
Score = 48.9 bits (115), Expect = 8e-06
Identities = 67/312 (21%), Positives = 137/312 (43%), Gaps = 59/312 (18%)
Query: 89 ERLAKDSEKLKEEIGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVST 148
++ A++ E+L E + LE+ R HA +Q + +ELQQR++ + R + +
Sbjct: 1357 QQRAEERERLAE-VEAALEKQRQLAEAHAQAKAQAERE-AKELQQRMQEEVVR-REEAAV 1413
Query: 149 QAEQLRRQLTPYAQRMERVLRENADS-LQASLRPH--ADELKAKIDQNV----------E 195
A+Q +R + Q+ LR+++++ +QA R A+ + +I++ + E
Sbjct: 1414 DAQQQKRSIQEELQQ----LRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE 1469
Query: 196 ELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAE-ELKA 254
+G + + ++ + R+ AQ+ E+L Q++ + Q K+ AE EL +
Sbjct: 1470 RQRGGAEGELQALRARAEEAEAQKRQ-----AQEEAERLRRQVQDES-QRKRQAEVELAS 1523
Query: 255 RISASAEELRQRLAPLAEDVRGNLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENF 314
R+ A AE R++ Q++L Q +EE R + E
Sbjct: 1524 RVKAEAEAAREK-------------------QRAL--------QALEELRLQAEEAERRL 1556
Query: 315 NKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDKVNSFFSTFKEKESQDKTLSLPELE 374
+A V++ Q++ L E L +K E+ Q++ +++ +L
Sbjct: 1557 RQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL-----ERSLQEEHVAVAQLR 1611
Query: 375 QQQEQQQEQQQE 386
++ E++ +QQ E
Sbjct: 1612 EEAERRAQQQAE 1623
Score = 48.1 bits (113), Expect = 1e-05
Identities = 86/364 (23%), Positives = 147/364 (40%), Gaps = 31/364 (8%)
Query: 44 EAVEHLQKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSE--KLKEE 101
EA + +E +L AL ++ + D ++ L E+LA E +LK E
Sbjct: 1796 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE 1855
Query: 102 IGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVSTQAEQLRRQLTPYA 161
L+E A NE +++ ++ ++RLE A Q + + + QLR+
Sbjct: 1856 AEIALKEKEAE-----NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1910
Query: 162 QR----MERVLRENADSLQASLRPHADELKAKIDQNVEELK-GRLTPYADEFKVKIDQTV 216
+R +E LR+ + L A KA + EL+ GR+ A++ +Q
Sbjct: 1911 ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 1970
Query: 217 EELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELKARISASAEELRQRLAPLAEDVRG 276
E R A++ + + + Q AEE AR +A E +RL E+ R
Sbjct: 1971 LEAARQRQLAAEEERRRREAEER---VQKSLAAEEEAARQRKAALEEVERLKAKVEEAR- 2026
Query: 277 NLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENF-----NKALVQQMEQLRQKLGP 331
LR E Q+S +L L Q+ + R + E F + L Q ++Q + L
Sbjct: 2027 RLRERAE--QESARQL--QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2082
Query: 332 HAGDVEGHLSFLEKDLRDKVNSFFSTFKEKESQDKTLSLPELEQQQEQQQEQQQEQVQML 391
G+ E E+ +V + E+E+ + E E+ ++ +EQ Q + Q
Sbjct: 2083 LRGEAEAARRAAEEAEEARVQA------EREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2136
Query: 392 APLE 395
A E
Sbjct: 2137 AAAE 2140
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 65.1 bits (157), Expect = 1e-10
Identities = 84/353 (23%), Positives = 146/353 (41%), Gaps = 58/353 (16%)
Query: 77 QKKLVPFATELHERLAKDSEKLKEEIGKELEELRARLLPHANEVSQKIGDNLRELQQRLE 136
QK+ E H++ A+ + + K ++ +EL LR + L + + + L+ L+
Sbjct: 2159 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ-LEETDHQKNLLDEELQRLKAEAT 2217
Query: 137 PYADQLRTQVSTQAEQLRRQLTPYAQRMERVLREN-------ADSLQASLRPHADELKAK 189
A Q R+QV + +R Q+ ++ R+ EN D+ Q L+ A+++K
Sbjct: 2218 EAARQ-RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK-- 2274
Query: 190 IDQNVEELKGRLTPYADEFKVKIDQTVEE--------LRRSLAPYAQDTQEKLNHQLEG- 240
V E RL+ A E ++ Q EE + L Q QE + E
Sbjct: 2275 ---QVAEEAARLSVAAQE-AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE 2330
Query: 241 LTFQMKKNAEELKARISASAEELRQRLAPLAEDVRGNLR----------GNTEGLQKSLA 290
L Q K+ A+E R+ E++ Q+LA + + L E L+ +A
Sbjct: 2331 LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2390
Query: 291 ELG---GHLDQQVEEFRRRVEPYGENFNK---------ALVQQMEQLRQKLGPHAGDVEG 338
E+ ++ + FR++ E GE ++ LVQ +E RQ+ A +
Sbjct: 2391 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2450
Query: 339 HLSFLEKDLRDKVNSFFSTFKEKESQDKTLSLPELEQQQEQQQEQQQEQVQML 391
++ LE++ KEK Q+ L + E+ Q QQEQ ++ Q L
Sbjct: 2451 AIAELERE------------KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL 2491
Score = 61.6 bits (148), Expect = 1e-09
Identities = 94/406 (23%), Positives = 174/406 (42%), Gaps = 63/406 (15%)
Query: 36 SQLSNNAKEAVEHL-QKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKD 94
+++ + K A + L QK+++ Q+L L + +L E + L ++L E E A+
Sbjct: 2165 AEMEKHKKFAEQTLRQKAQVEQELTTL-RLQLEETDHQKNLLDEELQRLKAEATEA-ARQ 2222
Query: 95 SEKLKEEIG------KELEELRARLLPHANEVSQKIGDN----LRELQQRLEPYADQL-R 143
+++EE+ +EL +L+AR+ + + DN L+E ++++ A++ R
Sbjct: 2223 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR 2282
Query: 144 TQVSTQAEQLRRQLTPYAQRMERVLRENADSLQASLRPHADELKAKIDQNVEELKGRLTP 203
V+ Q RQL +R L E + A LKA+ EL +
Sbjct: 2283 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA-----ELLQQQKE 2337
Query: 204 YADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELKARIS------ 257
A E ++ + E++ + LA Q Q L + + +M AE LK R++
Sbjct: 2338 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR-QLEMSAEAERLKLRVAEMSRAQ 2396
Query: 258 ASAEELRQRLAPLAEDVRGNLRG------------------------NTEGLQKSLAELG 293
A AEE QR AE++ L + E L++++AEL
Sbjct: 2397 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2456
Query: 294 GH---LDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDK 350
L Q+ + + + E + L+Q+ + L+Q + F+E++ + K
Sbjct: 2457 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE-KAK 2515
Query: 351 VNSFFSTFKEKESQDKTLSLPEL-EQQQEQQQEQQQEQVQMLAPLE 395
+ F QD+ +L E+QQ QQQ+ +QE+ +++A +E
Sbjct: 2516 LEQLF--------QDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2553
Score = 52.8 bits (125), Expect = 5e-07
Identities = 87/389 (22%), Positives = 173/389 (44%), Gaps = 54/389 (13%)
Query: 19 RAEVSADQVATVMWD------YFSQLSNNAKEAVEHLQKSELTQQ----LNALFQDKLGE 68
+A + A+ A ++ D + + + K+ E + + Q L L ++ L +
Sbjct: 2244 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2303
Query: 69 VNTYAGDLQKKLVPFATELHERLAKDSEKLKEEIGKELEELRARLLPHANE-VSQKIGDN 127
A + K+ + E RL ++E L+++ KEL + +AR L E ++Q++ +
Sbjct: 2304 QRALAEKMLKEKMQAVQEA-TRLKAEAELLQQQ--KELAQEQARRLQEDKEQMAQQLAEE 2360
Query: 128 LRELQQRLEPYADQLRTQVSTQAEQLRRQLTPYAQRMERVLRENADSLQASLRPHADELK 187
+ Q+ LE Q + ++S +AE+L+ ++ ++ R A+ R A+E+
Sbjct: 2361 TQGFQRTLEAER-QRQLEMSAEAERLKLRVAEMSRAQAR-----AEEDAQRFRKQAEEIG 2414
Query: 188 AKIDQN--VEELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQM 245
K+ + + K L + + + D E LR ++A ++ +EKL Q E Q+
Sbjct: 2415 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE-KEKL--QQEAKLLQL 2471
Query: 246 KKNAEELKARISASAEELRQRLAPLAEDV---RGNLRGNTEGLQKSLAELGGHLDQQVEE 302
K +EE++ + E+L Q L + + +L +++ A+L +V +
Sbjct: 2472 K--SEEMQ---TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAK 2526
Query: 303 FRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDKVNSFFSTFKEKE 362
++ E + QQMEQ RQ+L ++ +E+ R + + E+
Sbjct: 2527 AQQLREE-----QQRQQQQMEQERQRL----------VASMEEARRRQHEA------EEG 2565
Query: 363 SQDKTLSLPELEQQQEQQQEQQQEQVQML 391
+ K L +LEQQ+ QQ+E E+ Q L
Sbjct: 2566 VRRKQEELQQLEQQRRQQEELLAEENQRL 2594
Score = 52.4 bits (124), Expect = 7e-07
Identities = 92/396 (23%), Positives = 166/396 (41%), Gaps = 55/396 (13%)
Query: 37 QLSNNAKEAVEHLQKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSE 96
+L+ E L + Q+L A + T G+ Q++L+ +R A +
Sbjct: 1688 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1747
Query: 97 KLKEEIGKELEELRAR---LLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVSTQAEQL 153
+ ++E+ EL ++RA LL ++ + +QRLE A + R +++ +A +L
Sbjct: 1748 QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR-ELAEEAARL 1806
Query: 154 RRQLTPYAQRMERVLRENADSLQASLRP----------HADELKAKIDQNVEELKG---- 199
R L A+R ++ E+A +A A LK + + ++E +
Sbjct: 1807 RA-LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENER 1865
Query: 200 -------------RLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQMK 246
RL A + K I++ + +LR+ A D++ + L T + +
Sbjct: 1866 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK-----ASDSELERQKGLVEDTLRQR 1920
Query: 247 KNAEELKARISASAEELRQRLAPLAEDVRGNLRGNTEGL--QKSLAELGGHLDQQV--EE 302
+ EE + AS E+ A L ++ G +R N E K AEL +Q+ EE
Sbjct: 1921 RQVEEEILALKASFEKAAAGKAELELEL-GRIRSNAEDTLRSKEQAELEAARQRQLAAEE 1979
Query: 303 FRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLE--KDLRDKVNSFFS---- 356
RRR E E K+L + E RQ+ +VE + +E + LR++ +
Sbjct: 1980 ERRRREAE-ERVQKSLAAEEEAARQRKAA-LEEVERLKAKVEEARRLRERAEQESARQLQ 2037
Query: 357 -----TFKEKESQDKTLSLPELEQQQEQQQEQQQEQ 387
K ++++K + +++QE QQ QQEQ
Sbjct: 2038 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2073
Score = 50.4 bits (119), Expect = 3e-06
Identities = 81/355 (22%), Positives = 145/355 (40%), Gaps = 43/355 (12%)
Query: 2 FLKAVVLTLALVAVAGARAEVSADQVATVMWDYFSQLSNNAKEAVEHLQKSELTQQLNAL 61
FL+ + VA AR V+A + A + QL+ L + L +++ A+
Sbjct: 2265 FLQEEAEKMKQVAEEAARLSVAAQEAARLR-----QLAEEDLAQQRALAEKMLKEKMQAV 2319
Query: 62 FQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSEKLKEEIGKE-------LEELRARLL 114
+ + QK+L A E RL +D E++ +++ +E LE R R L
Sbjct: 2320 QEATRLKAEAELLQQQKEL---AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2376
Query: 115 PHANEVSQ---KIGDNLRELQQRLEPYADQLRTQVSTQAEQLRR------QLTPYAQRME 165
+ E + ++ + R Q R E A + R Q E+L R + Q +E
Sbjct: 2377 EMSAEAERLKLRVAEMSRA-QARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2435
Query: 166 RVLRENADSLQASLRPHADELKAKIDQNVEELKGRLTPYADEFKVKIDQTVEELRRSLAP 225
+ R+ +D LR EL+ + ++ +E K + V+ +Q ++E +
Sbjct: 2436 -IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2494
Query: 226 YAQDTQEKLNHQ---------LEGLTFQMKKNAEELKA---RISASAEELRQRLAPLAED 273
+ + L + LE L A++L+ R E+ RQRL E+
Sbjct: 2495 FLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE 2554
Query: 274 VRGNLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQK 328
R EG+++ EL QQ+E+ RR+ E N+ L +Q++ L ++
Sbjct: 2555 ARRRQHEAEEGVRRKQEEL-----QQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2604
Score = 48.9 bits (115), Expect = 8e-06
Identities = 67/312 (21%), Positives = 137/312 (43%), Gaps = 59/312 (18%)
Query: 89 ERLAKDSEKLKEEIGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVST 148
++ A++ E+L E + LE+ R HA +Q + +ELQQR++ + R + +
Sbjct: 1353 QQRAEERERLAE-VEAALEKQRQLAEAHAQAKAQAERE-AKELQQRMQEEVVR-REEAAV 1409
Query: 149 QAEQLRRQLTPYAQRMERVLRENADS-LQASLRPH--ADELKAKIDQNV----------E 195
A+Q +R + Q+ LR+++++ +QA R A+ + +I++ + E
Sbjct: 1410 DAQQQKRSIQEELQQ----LRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE 1465
Query: 196 ELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAE-ELKA 254
+G + + ++ + R+ AQ+ E+L Q++ + Q K+ AE EL +
Sbjct: 1466 RQRGGAEGELQALRARAEEAEAQKRQ-----AQEEAERLRRQVQDES-QRKRQAEVELAS 1519
Query: 255 RISASAEELRQRLAPLAEDVRGNLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENF 314
R+ A AE R++ Q++L Q +EE R + E
Sbjct: 1520 RVKAEAEAAREK-------------------QRAL--------QALEELRLQAEEAERRL 1552
Query: 315 NKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDKVNSFFSTFKEKESQDKTLSLPELE 374
+A V++ Q++ L E L +K E+ Q++ +++ +L
Sbjct: 1553 RQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL-----ERSLQEEHVAVAQLR 1607
Query: 375 QQQEQQQEQQQE 386
++ E++ +QQ E
Sbjct: 1608 EEAERRAQQQAE 1619
Score = 48.1 bits (113), Expect = 1e-05
Identities = 86/364 (23%), Positives = 147/364 (40%), Gaps = 31/364 (8%)
Query: 44 EAVEHLQKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSE--KLKEE 101
EA + +E +L AL ++ + D ++ L E+LA E +LK E
Sbjct: 1792 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE 1851
Query: 102 IGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVSTQAEQLRRQLTPYA 161
L+E A NE +++ ++ ++RLE A Q + + + QLR+
Sbjct: 1852 AEIALKEKEAE-----NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1906
Query: 162 QR----MERVLRENADSLQASLRPHADELKAKIDQNVEELK-GRLTPYADEFKVKIDQTV 216
+R +E LR+ + L A KA + EL+ GR+ A++ +Q
Sbjct: 1907 ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 1966
Query: 217 EELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELKARISASAEELRQRLAPLAEDVRG 276
E R A++ + + + Q AEE AR +A E +RL E+ R
Sbjct: 1967 LEAARQRQLAAEEERRRREAEER---VQKSLAAEEEAARQRKAALEEVERLKAKVEEAR- 2022
Query: 277 NLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENF-----NKALVQQMEQLRQKLGP 331
LR E Q+S +L L Q+ + R + E F + L Q ++Q + L
Sbjct: 2023 RLRERAE--QESARQL--QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2078
Query: 332 HAGDVEGHLSFLEKDLRDKVNSFFSTFKEKESQDKTLSLPELEQQQEQQQEQQQEQVQML 391
G+ E E+ +V + E+E+ + E E+ ++ +EQ Q + Q
Sbjct: 2079 LRGEAEAARRAAEEAEEARVQA------EREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2132
Query: 392 APLE 395
A E
Sbjct: 2133 AAAE 2136
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 65.1 bits (157), Expect = 1e-10
Identities = 84/353 (23%), Positives = 146/353 (41%), Gaps = 58/353 (16%)
Query: 77 QKKLVPFATELHERLAKDSEKLKEEIGKELEELRARLLPHANEVSQKIGDNLRELQQRLE 136
QK+ E H++ A+ + + K ++ +EL LR + L + + + L+ L+
Sbjct: 2127 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ-LEETDHQKNLLDEELQRLKAEAT 2185
Query: 137 PYADQLRTQVSTQAEQLRRQLTPYAQRMERVLREN-------ADSLQASLRPHADELKAK 189
A Q R+QV + +R Q+ ++ R+ EN D+ Q L+ A+++K
Sbjct: 2186 EAARQ-RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK-- 2242
Query: 190 IDQNVEELKGRLTPYADEFKVKIDQTVEE--------LRRSLAPYAQDTQEKLNHQLEG- 240
V E RL+ A E ++ Q EE + L Q QE + E
Sbjct: 2243 ---QVAEEAARLSVAAQE-AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE 2298
Query: 241 LTFQMKKNAEELKARISASAEELRQRLAPLAEDVRGNLR----------GNTEGLQKSLA 290
L Q K+ A+E R+ E++ Q+LA + + L E L+ +A
Sbjct: 2299 LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2358
Query: 291 ELG---GHLDQQVEEFRRRVEPYGENFNK---------ALVQQMEQLRQKLGPHAGDVEG 338
E+ ++ + FR++ E GE ++ LVQ +E RQ+ A +
Sbjct: 2359 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2418
Query: 339 HLSFLEKDLRDKVNSFFSTFKEKESQDKTLSLPELEQQQEQQQEQQQEQVQML 391
++ LE++ KEK Q+ L + E+ Q QQEQ ++ Q L
Sbjct: 2419 AIAELERE------------KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL 2459
Score = 61.6 bits (148), Expect = 1e-09
Identities = 94/406 (23%), Positives = 174/406 (42%), Gaps = 63/406 (15%)
Query: 36 SQLSNNAKEAVEHL-QKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKD 94
+++ + K A + L QK+++ Q+L L + +L E + L ++L E E A+
Sbjct: 2133 AEMEKHKKFAEQTLRQKAQVEQELTTL-RLQLEETDHQKNLLDEELQRLKAEATEA-ARQ 2190
Query: 95 SEKLKEEIG------KELEELRARLLPHANEVSQKIGDN----LRELQQRLEPYADQL-R 143
+++EE+ +EL +L+AR+ + + DN L+E ++++ A++ R
Sbjct: 2191 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR 2250
Query: 144 TQVSTQAEQLRRQLTPYAQRMERVLRENADSLQASLRPHADELKAKIDQNVEELKGRLTP 203
V+ Q RQL +R L E + A LKA+ EL +
Sbjct: 2251 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA-----ELLQQQKE 2305
Query: 204 YADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELKARIS------ 257
A E ++ + E++ + LA Q Q L + + +M AE LK R++
Sbjct: 2306 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR-QLEMSAEAERLKLRVAEMSRAQ 2364
Query: 258 ASAEELRQRLAPLAEDVRGNLRG------------------------NTEGLQKSLAELG 293
A AEE QR AE++ L + E L++++AEL
Sbjct: 2365 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2424
Query: 294 GH---LDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDK 350
L Q+ + + + E + L+Q+ + L+Q + F+E++ + K
Sbjct: 2425 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE-KAK 2483
Query: 351 VNSFFSTFKEKESQDKTLSLPEL-EQQQEQQQEQQQEQVQMLAPLE 395
+ F QD+ +L E+QQ QQQ+ +QE+ +++A +E
Sbjct: 2484 LEQLF--------QDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2521
Score = 52.8 bits (125), Expect = 5e-07
Identities = 87/389 (22%), Positives = 173/389 (44%), Gaps = 54/389 (13%)
Query: 19 RAEVSADQVATVMWD------YFSQLSNNAKEAVEHLQKSELTQQ----LNALFQDKLGE 68
+A + A+ A ++ D + + + K+ E + + Q L L ++ L +
Sbjct: 2212 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2271
Query: 69 VNTYAGDLQKKLVPFATELHERLAKDSEKLKEEIGKELEELRARLLPHANE-VSQKIGDN 127
A + K+ + E RL ++E L+++ KEL + +AR L E ++Q++ +
Sbjct: 2272 QRALAEKMLKEKMQAVQEA-TRLKAEAELLQQQ--KELAQEQARRLQEDKEQMAQQLAEE 2328
Query: 128 LRELQQRLEPYADQLRTQVSTQAEQLRRQLTPYAQRMERVLRENADSLQASLRPHADELK 187
+ Q+ LE Q + ++S +AE+L+ ++ ++ R A+ R A+E+
Sbjct: 2329 TQGFQRTLEAER-QRQLEMSAEAERLKLRVAEMSRAQAR-----AEEDAQRFRKQAEEIG 2382
Query: 188 AKIDQN--VEELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQM 245
K+ + + K L + + + D E LR ++A ++ +EKL Q E Q+
Sbjct: 2383 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE-KEKL--QQEAKLLQL 2439
Query: 246 KKNAEELKARISASAEELRQRLAPLAEDV---RGNLRGNTEGLQKSLAELGGHLDQQVEE 302
K +EE++ + E+L Q L + + +L +++ A+L +V +
Sbjct: 2440 K--SEEMQ---TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAK 2494
Query: 303 FRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDKVNSFFSTFKEKE 362
++ E + QQMEQ RQ+L ++ +E+ R + + E+
Sbjct: 2495 AQQLREE-----QQRQQQQMEQERQRL----------VASMEEARRRQHEA------EEG 2533
Query: 363 SQDKTLSLPELEQQQEQQQEQQQEQVQML 391
+ K L +LEQQ+ QQ+E E+ Q L
Sbjct: 2534 VRRKQEELQQLEQQRRQQEELLAEENQRL 2562
Score = 52.4 bits (124), Expect = 7e-07
Identities = 92/396 (23%), Positives = 166/396 (41%), Gaps = 55/396 (13%)
Query: 37 QLSNNAKEAVEHLQKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSE 96
+L+ E L + Q+L A + T G+ Q++L+ +R A +
Sbjct: 1656 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1715
Query: 97 KLKEEIGKELEELRAR---LLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVSTQAEQL 153
+ ++E+ EL ++RA LL ++ + +QRLE A + R +++ +A +L
Sbjct: 1716 QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR-ELAEEAARL 1774
Query: 154 RRQLTPYAQRMERVLRENADSLQASLRP----------HADELKAKIDQNVEELKG---- 199
R L A+R ++ E+A +A A LK + + ++E +
Sbjct: 1775 RA-LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENER 1833
Query: 200 -------------RLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQMK 246
RL A + K I++ + +LR+ A D++ + L T + +
Sbjct: 1834 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK-----ASDSELERQKGLVEDTLRQR 1888
Query: 247 KNAEELKARISASAEELRQRLAPLAEDVRGNLRGNTEGL--QKSLAELGGHLDQQV--EE 302
+ EE + AS E+ A L ++ G +R N E K AEL +Q+ EE
Sbjct: 1889 RQVEEEILALKASFEKAAAGKAELELEL-GRIRSNAEDTLRSKEQAELEAARQRQLAAEE 1947
Query: 303 FRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLE--KDLRDKVNSFFS---- 356
RRR E E K+L + E RQ+ +VE + +E + LR++ +
Sbjct: 1948 ERRRREAE-ERVQKSLAAEEEAARQRKAA-LEEVERLKAKVEEARRLRERAEQESARQLQ 2005
Query: 357 -----TFKEKESQDKTLSLPELEQQQEQQQEQQQEQ 387
K ++++K + +++QE QQ QQEQ
Sbjct: 2006 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2041
Score = 50.4 bits (119), Expect = 3e-06
Identities = 81/355 (22%), Positives = 145/355 (40%), Gaps = 43/355 (12%)
Query: 2 FLKAVVLTLALVAVAGARAEVSADQVATVMWDYFSQLSNNAKEAVEHLQKSELTQQLNAL 61
FL+ + VA AR V+A + A + QL+ L + L +++ A+
Sbjct: 2233 FLQEEAEKMKQVAEEAARLSVAAQEAARLR-----QLAEEDLAQQRALAEKMLKEKMQAV 2287
Query: 62 FQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSEKLKEEIGKE-------LEELRARLL 114
+ + QK+L A E RL +D E++ +++ +E LE R R L
Sbjct: 2288 QEATRLKAEAELLQQQKEL---AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2344
Query: 115 PHANEVSQ---KIGDNLRELQQRLEPYADQLRTQVSTQAEQLRR------QLTPYAQRME 165
+ E + ++ + R Q R E A + R Q E+L R + Q +E
Sbjct: 2345 EMSAEAERLKLRVAEMSRA-QARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2403
Query: 166 RVLRENADSLQASLRPHADELKAKIDQNVEELKGRLTPYADEFKVKIDQTVEELRRSLAP 225
+ R+ +D LR EL+ + ++ +E K + V+ +Q ++E +
Sbjct: 2404 -IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2462
Query: 226 YAQDTQEKLNHQ---------LEGLTFQMKKNAEELKA---RISASAEELRQRLAPLAED 273
+ + L + LE L A++L+ R E+ RQRL E+
Sbjct: 2463 FLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE 2522
Query: 274 VRGNLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQK 328
R EG+++ EL QQ+E+ RR+ E N+ L +Q++ L ++
Sbjct: 2523 ARRRQHEAEEGVRRKQEEL-----QQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2572
Score = 48.9 bits (115), Expect = 8e-06
Identities = 67/312 (21%), Positives = 137/312 (43%), Gaps = 59/312 (18%)
Query: 89 ERLAKDSEKLKEEIGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVST 148
++ A++ E+L E + LE+ R HA +Q + +ELQQR++ + R + +
Sbjct: 1321 QQRAEERERLAE-VEAALEKQRQLAEAHAQAKAQAERE-AKELQQRMQEEVVR-REEAAV 1377
Query: 149 QAEQLRRQLTPYAQRMERVLRENADS-LQASLRPH--ADELKAKIDQNV----------E 195
A+Q +R + Q+ LR+++++ +QA R A+ + +I++ + E
Sbjct: 1378 DAQQQKRSIQEELQQ----LRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE 1433
Query: 196 ELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAE-ELKA 254
+G + + ++ + R+ AQ+ E+L Q++ + Q K+ AE EL +
Sbjct: 1434 RQRGGAEGELQALRARAEEAEAQKRQ-----AQEEAERLRRQVQDES-QRKRQAEVELAS 1487
Query: 255 RISASAEELRQRLAPLAEDVRGNLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENF 314
R+ A AE R++ Q++L Q +EE R + E
Sbjct: 1488 RVKAEAEAAREK-------------------QRAL--------QALEELRLQAEEAERRL 1520
Query: 315 NKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDKVNSFFSTFKEKESQDKTLSLPELE 374
+A V++ Q++ L E L +K E+ Q++ +++ +L
Sbjct: 1521 RQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL-----ERSLQEEHVAVAQLR 1575
Query: 375 QQQEQQQEQQQE 386
++ E++ +QQ E
Sbjct: 1576 EEAERRAQQQAE 1587
Score = 48.1 bits (113), Expect = 1e-05
Identities = 86/364 (23%), Positives = 147/364 (40%), Gaps = 31/364 (8%)
Query: 44 EAVEHLQKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSE--KLKEE 101
EA + +E +L AL ++ + D ++ L E+LA E +LK E
Sbjct: 1760 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE 1819
Query: 102 IGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVSTQAEQLRRQLTPYA 161
L+E A NE +++ ++ ++RLE A Q + + + QLR+
Sbjct: 1820 AEIALKEKEAE-----NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1874
Query: 162 QR----MERVLRENADSLQASLRPHADELKAKIDQNVEELK-GRLTPYADEFKVKIDQTV 216
+R +E LR+ + L A KA + EL+ GR+ A++ +Q
Sbjct: 1875 ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 1934
Query: 217 EELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELKARISASAEELRQRLAPLAEDVRG 276
E R A++ + + + Q AEE AR +A E +RL E+ R
Sbjct: 1935 LEAARQRQLAAEEERRRREAEER---VQKSLAAEEEAARQRKAALEEVERLKAKVEEAR- 1990
Query: 277 NLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENF-----NKALVQQMEQLRQKLGP 331
LR E Q+S +L L Q+ + R + E F + L Q ++Q + L
Sbjct: 1991 RLRERAE--QESARQL--QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2046
Query: 332 HAGDVEGHLSFLEKDLRDKVNSFFSTFKEKESQDKTLSLPELEQQQEQQQEQQQEQVQML 391
G+ E E+ +V + E+E+ + E E+ ++ +EQ Q + Q
Sbjct: 2047 LRGEAEAARRAAEEAEEARVQA------EREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2100
Query: 392 APLE 395
A E
Sbjct: 2101 AAAE 2104
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 65.1 bits (157), Expect = 1e-10
Identities = 84/353 (23%), Positives = 146/353 (41%), Gaps = 58/353 (16%)
Query: 77 QKKLVPFATELHERLAKDSEKLKEEIGKELEELRARLLPHANEVSQKIGDNLRELQQRLE 136
QK+ E H++ A+ + + K ++ +EL LR + L + + + L+ L+
Sbjct: 2296 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ-LEETDHQKNLLDEELQRLKAEAT 2354
Query: 137 PYADQLRTQVSTQAEQLRRQLTPYAQRMERVLREN-------ADSLQASLRPHADELKAK 189
A Q R+QV + +R Q+ ++ R+ EN D+ Q L+ A+++K
Sbjct: 2355 EAARQ-RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK-- 2411
Query: 190 IDQNVEELKGRLTPYADEFKVKIDQTVEE--------LRRSLAPYAQDTQEKLNHQLEG- 240
V E RL+ A E ++ Q EE + L Q QE + E
Sbjct: 2412 ---QVAEEAARLSVAAQE-AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE 2467
Query: 241 LTFQMKKNAEELKARISASAEELRQRLAPLAEDVRGNLR----------GNTEGLQKSLA 290
L Q K+ A+E R+ E++ Q+LA + + L E L+ +A
Sbjct: 2468 LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2527
Query: 291 ELG---GHLDQQVEEFRRRVEPYGENFNK---------ALVQQMEQLRQKLGPHAGDVEG 338
E+ ++ + FR++ E GE ++ LVQ +E RQ+ A +
Sbjct: 2528 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2587
Query: 339 HLSFLEKDLRDKVNSFFSTFKEKESQDKTLSLPELEQQQEQQQEQQQEQVQML 391
++ LE++ KEK Q+ L + E+ Q QQEQ ++ Q L
Sbjct: 2588 AIAELERE------------KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL 2628
Score = 61.6 bits (148), Expect = 1e-09
Identities = 94/406 (23%), Positives = 174/406 (42%), Gaps = 63/406 (15%)
Query: 36 SQLSNNAKEAVEHL-QKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKD 94
+++ + K A + L QK+++ Q+L L + +L E + L ++L E E A+
Sbjct: 2302 AEMEKHKKFAEQTLRQKAQVEQELTTL-RLQLEETDHQKNLLDEELQRLKAEATEA-ARQ 2359
Query: 95 SEKLKEEIG------KELEELRARLLPHANEVSQKIGDN----LRELQQRLEPYADQL-R 143
+++EE+ +EL +L+AR+ + + DN L+E ++++ A++ R
Sbjct: 2360 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR 2419
Query: 144 TQVSTQAEQLRRQLTPYAQRMERVLRENADSLQASLRPHADELKAKIDQNVEELKGRLTP 203
V+ Q RQL +R L E + A LKA+ EL +
Sbjct: 2420 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA-----ELLQQQKE 2474
Query: 204 YADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELKARIS------ 257
A E ++ + E++ + LA Q Q L + + +M AE LK R++
Sbjct: 2475 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR-QLEMSAEAERLKLRVAEMSRAQ 2533
Query: 258 ASAEELRQRLAPLAEDVRGNLRG------------------------NTEGLQKSLAELG 293
A AEE QR AE++ L + E L++++AEL
Sbjct: 2534 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2593
Query: 294 GH---LDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDK 350
L Q+ + + + E + L+Q+ + L+Q + F+E++ + K
Sbjct: 2594 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE-KAK 2652
Query: 351 VNSFFSTFKEKESQDKTLSLPEL-EQQQEQQQEQQQEQVQMLAPLE 395
+ F QD+ +L E+QQ QQQ+ +QE+ +++A +E
Sbjct: 2653 LEQLF--------QDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2690
Score = 52.8 bits (125), Expect = 5e-07
Identities = 87/389 (22%), Positives = 173/389 (44%), Gaps = 54/389 (13%)
Query: 19 RAEVSADQVATVMWD------YFSQLSNNAKEAVEHLQKSELTQQ----LNALFQDKLGE 68
+A + A+ A ++ D + + + K+ E + + Q L L ++ L +
Sbjct: 2381 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2440
Query: 69 VNTYAGDLQKKLVPFATELHERLAKDSEKLKEEIGKELEELRARLLPHANE-VSQKIGDN 127
A + K+ + E RL ++E L+++ KEL + +AR L E ++Q++ +
Sbjct: 2441 QRALAEKMLKEKMQAVQEA-TRLKAEAELLQQQ--KELAQEQARRLQEDKEQMAQQLAEE 2497
Query: 128 LRELQQRLEPYADQLRTQVSTQAEQLRRQLTPYAQRMERVLRENADSLQASLRPHADELK 187
+ Q+ LE Q + ++S +AE+L+ ++ ++ R A+ R A+E+
Sbjct: 2498 TQGFQRTLEAER-QRQLEMSAEAERLKLRVAEMSRAQAR-----AEEDAQRFRKQAEEIG 2551
Query: 188 AKIDQN--VEELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQM 245
K+ + + K L + + + D E LR ++A ++ +EKL Q E Q+
Sbjct: 2552 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE-KEKL--QQEAKLLQL 2608
Query: 246 KKNAEELKARISASAEELRQRLAPLAEDV---RGNLRGNTEGLQKSLAELGGHLDQQVEE 302
K +EE++ + E+L Q L + + +L +++ A+L +V +
Sbjct: 2609 K--SEEMQ---TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAK 2663
Query: 303 FRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDKVNSFFSTFKEKE 362
++ E + QQMEQ RQ+L ++ +E+ R + + E+
Sbjct: 2664 AQQLREE-----QQRQQQQMEQERQRL----------VASMEEARRRQHEA------EEG 2702
Query: 363 SQDKTLSLPELEQQQEQQQEQQQEQVQML 391
+ K L +LEQQ+ QQ+E E+ Q L
Sbjct: 2703 VRRKQEELQQLEQQRRQQEELLAEENQRL 2731
Score = 52.4 bits (124), Expect = 7e-07
Identities = 92/396 (23%), Positives = 166/396 (41%), Gaps = 55/396 (13%)
Query: 37 QLSNNAKEAVEHLQKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSE 96
+L+ E L + Q+L A + T G+ Q++L+ +R A +
Sbjct: 1825 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1884
Query: 97 KLKEEIGKELEELRAR---LLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVSTQAEQL 153
+ ++E+ EL ++RA LL ++ + +QRLE A + R +++ +A +L
Sbjct: 1885 QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR-ELAEEAARL 1943
Query: 154 RRQLTPYAQRMERVLRENADSLQASLRP----------HADELKAKIDQNVEELKG---- 199
R L A+R ++ E+A +A A LK + + ++E +
Sbjct: 1944 RA-LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENER 2002
Query: 200 -------------RLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQMK 246
RL A + K I++ + +LR+ A D++ + L T + +
Sbjct: 2003 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK-----ASDSELERQKGLVEDTLRQR 2057
Query: 247 KNAEELKARISASAEELRQRLAPLAEDVRGNLRGNTEGL--QKSLAELGGHLDQQV--EE 302
+ EE + AS E+ A L ++ G +R N E K AEL +Q+ EE
Sbjct: 2058 RQVEEEILALKASFEKAAAGKAELELEL-GRIRSNAEDTLRSKEQAELEAARQRQLAAEE 2116
Query: 303 FRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLE--KDLRDKVNSFFS---- 356
RRR E E K+L + E RQ+ +VE + +E + LR++ +
Sbjct: 2117 ERRRREAE-ERVQKSLAAEEEAARQRKAA-LEEVERLKAKVEEARRLRERAEQESARQLQ 2174
Query: 357 -----TFKEKESQDKTLSLPELEQQQEQQQEQQQEQ 387
K ++++K + +++QE QQ QQEQ
Sbjct: 2175 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2210
Score = 50.4 bits (119), Expect = 3e-06
Identities = 81/355 (22%), Positives = 145/355 (40%), Gaps = 43/355 (12%)
Query: 2 FLKAVVLTLALVAVAGARAEVSADQVATVMWDYFSQLSNNAKEAVEHLQKSELTQQLNAL 61
FL+ + VA AR V+A + A + QL+ L + L +++ A+
Sbjct: 2402 FLQEEAEKMKQVAEEAARLSVAAQEAARLR-----QLAEEDLAQQRALAEKMLKEKMQAV 2456
Query: 62 FQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSEKLKEEIGKE-------LEELRARLL 114
+ + QK+L A E RL +D E++ +++ +E LE R R L
Sbjct: 2457 QEATRLKAEAELLQQQKEL---AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2513
Query: 115 PHANEVSQ---KIGDNLRELQQRLEPYADQLRTQVSTQAEQLRR------QLTPYAQRME 165
+ E + ++ + R Q R E A + R Q E+L R + Q +E
Sbjct: 2514 EMSAEAERLKLRVAEMSRA-QARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2572
Query: 166 RVLRENADSLQASLRPHADELKAKIDQNVEELKGRLTPYADEFKVKIDQTVEELRRSLAP 225
+ R+ +D LR EL+ + ++ +E K + V+ +Q ++E +
Sbjct: 2573 -IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2631
Query: 226 YAQDTQEKLNHQ---------LEGLTFQMKKNAEELKA---RISASAEELRQRLAPLAED 273
+ + L + LE L A++L+ R E+ RQRL E+
Sbjct: 2632 FLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE 2691
Query: 274 VRGNLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQK 328
R EG+++ EL QQ+E+ RR+ E N+ L +Q++ L ++
Sbjct: 2692 ARRRQHEAEEGVRRKQEEL-----QQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2741
Score = 48.9 bits (115), Expect = 8e-06
Identities = 67/312 (21%), Positives = 137/312 (43%), Gaps = 59/312 (18%)
Query: 89 ERLAKDSEKLKEEIGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVST 148
++ A++ E+L E + LE+ R HA +Q + +ELQQR++ + R + +
Sbjct: 1490 QQRAEERERLAE-VEAALEKQRQLAEAHAQAKAQAERE-AKELQQRMQEEVVR-REEAAV 1546
Query: 149 QAEQLRRQLTPYAQRMERVLRENADS-LQASLRPH--ADELKAKIDQNV----------E 195
A+Q +R + Q+ LR+++++ +QA R A+ + +I++ + E
Sbjct: 1547 DAQQQKRSIQEELQQ----LRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE 1602
Query: 196 ELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAE-ELKA 254
+G + + ++ + R+ AQ+ E+L Q++ + Q K+ AE EL +
Sbjct: 1603 RQRGGAEGELQALRARAEEAEAQKRQ-----AQEEAERLRRQVQDES-QRKRQAEVELAS 1656
Query: 255 RISASAEELRQRLAPLAEDVRGNLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENF 314
R+ A AE R++ Q++L Q +EE R + E
Sbjct: 1657 RVKAEAEAAREK-------------------QRAL--------QALEELRLQAEEAERRL 1689
Query: 315 NKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDKVNSFFSTFKEKESQDKTLSLPELE 374
+A V++ Q++ L E L +K E+ Q++ +++ +L
Sbjct: 1690 RQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL-----ERSLQEEHVAVAQLR 1744
Query: 375 QQQEQQQEQQQE 386
++ E++ +QQ E
Sbjct: 1745 EEAERRAQQQAE 1756
Score = 48.1 bits (113), Expect = 1e-05
Identities = 86/364 (23%), Positives = 147/364 (40%), Gaps = 31/364 (8%)
Query: 44 EAVEHLQKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSE--KLKEE 101
EA + +E +L AL ++ + D ++ L E+LA E +LK E
Sbjct: 1929 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE 1988
Query: 102 IGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVSTQAEQLRRQLTPYA 161
L+E A NE +++ ++ ++RLE A Q + + + QLR+
Sbjct: 1989 AEIALKEKEAE-----NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 2043
Query: 162 QR----MERVLRENADSLQASLRPHADELKAKIDQNVEELK-GRLTPYADEFKVKIDQTV 216
+R +E LR+ + L A KA + EL+ GR+ A++ +Q
Sbjct: 2044 ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 2103
Query: 217 EELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELKARISASAEELRQRLAPLAEDVRG 276
E R A++ + + + Q AEE AR +A E +RL E+ R
Sbjct: 2104 LEAARQRQLAAEEERRRREAEER---VQKSLAAEEEAARQRKAALEEVERLKAKVEEAR- 2159
Query: 277 NLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENF-----NKALVQQMEQLRQKLGP 331
LR E Q+S +L L Q+ + R + E F + L Q ++Q + L
Sbjct: 2160 RLRERAE--QESARQL--QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2215
Query: 332 HAGDVEGHLSFLEKDLRDKVNSFFSTFKEKESQDKTLSLPELEQQQEQQQEQQQEQVQML 391
G+ E E+ +V + E+E+ + E E+ ++ +EQ Q + Q
Sbjct: 2216 LRGEAEAARRAAEEAEEARVQA------EREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2269
Query: 392 APLE 395
A E
Sbjct: 2270 AAAE 2273
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 65.1 bits (157), Expect = 1e-10
Identities = 84/353 (23%), Positives = 146/353 (41%), Gaps = 58/353 (16%)
Query: 77 QKKLVPFATELHERLAKDSEKLKEEIGKELEELRARLLPHANEVSQKIGDNLRELQQRLE 136
QK+ E H++ A+ + + K ++ +EL LR + L + + + L+ L+
Sbjct: 2137 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ-LEETDHQKNLLDEELQRLKAEAT 2195
Query: 137 PYADQLRTQVSTQAEQLRRQLTPYAQRMERVLREN-------ADSLQASLRPHADELKAK 189
A Q R+QV + +R Q+ ++ R+ EN D+ Q L+ A+++K
Sbjct: 2196 EAARQ-RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK-- 2252
Query: 190 IDQNVEELKGRLTPYADEFKVKIDQTVEE--------LRRSLAPYAQDTQEKLNHQLEG- 240
V E RL+ A E ++ Q EE + L Q QE + E
Sbjct: 2253 ---QVAEEAARLSVAAQE-AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE 2308
Query: 241 LTFQMKKNAEELKARISASAEELRQRLAPLAEDVRGNLR----------GNTEGLQKSLA 290
L Q K+ A+E R+ E++ Q+LA + + L E L+ +A
Sbjct: 2309 LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2368
Query: 291 ELG---GHLDQQVEEFRRRVEPYGENFNK---------ALVQQMEQLRQKLGPHAGDVEG 338
E+ ++ + FR++ E GE ++ LVQ +E RQ+ A +
Sbjct: 2369 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2428
Query: 339 HLSFLEKDLRDKVNSFFSTFKEKESQDKTLSLPELEQQQEQQQEQQQEQVQML 391
++ LE++ KEK Q+ L + E+ Q QQEQ ++ Q L
Sbjct: 2429 AIAELERE------------KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL 2469
Score = 61.6 bits (148), Expect = 1e-09
Identities = 94/406 (23%), Positives = 174/406 (42%), Gaps = 63/406 (15%)
Query: 36 SQLSNNAKEAVEHL-QKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKD 94
+++ + K A + L QK+++ Q+L L + +L E + L ++L E E A+
Sbjct: 2143 AEMEKHKKFAEQTLRQKAQVEQELTTL-RLQLEETDHQKNLLDEELQRLKAEATEA-ARQ 2200
Query: 95 SEKLKEEIG------KELEELRARLLPHANEVSQKIGDN----LRELQQRLEPYADQL-R 143
+++EE+ +EL +L+AR+ + + DN L+E ++++ A++ R
Sbjct: 2201 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR 2260
Query: 144 TQVSTQAEQLRRQLTPYAQRMERVLRENADSLQASLRPHADELKAKIDQNVEELKGRLTP 203
V+ Q RQL +R L E + A LKA+ EL +
Sbjct: 2261 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA-----ELLQQQKE 2315
Query: 204 YADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELKARIS------ 257
A E ++ + E++ + LA Q Q L + + +M AE LK R++
Sbjct: 2316 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR-QLEMSAEAERLKLRVAEMSRAQ 2374
Query: 258 ASAEELRQRLAPLAEDVRGNLRG------------------------NTEGLQKSLAELG 293
A AEE QR AE++ L + E L++++AEL
Sbjct: 2375 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2434
Query: 294 GH---LDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDK 350
L Q+ + + + E + L+Q+ + L+Q + F+E++ + K
Sbjct: 2435 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE-KAK 2493
Query: 351 VNSFFSTFKEKESQDKTLSLPEL-EQQQEQQQEQQQEQVQMLAPLE 395
+ F QD+ +L E+QQ QQQ+ +QE+ +++A +E
Sbjct: 2494 LEQLF--------QDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2531
Score = 52.8 bits (125), Expect = 5e-07
Identities = 87/389 (22%), Positives = 173/389 (44%), Gaps = 54/389 (13%)
Query: 19 RAEVSADQVATVMWD------YFSQLSNNAKEAVEHLQKSELTQQ----LNALFQDKLGE 68
+A + A+ A ++ D + + + K+ E + + Q L L ++ L +
Sbjct: 2222 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2281
Query: 69 VNTYAGDLQKKLVPFATELHERLAKDSEKLKEEIGKELEELRARLLPHANE-VSQKIGDN 127
A + K+ + E RL ++E L+++ KEL + +AR L E ++Q++ +
Sbjct: 2282 QRALAEKMLKEKMQAVQEA-TRLKAEAELLQQQ--KELAQEQARRLQEDKEQMAQQLAEE 2338
Query: 128 LRELQQRLEPYADQLRTQVSTQAEQLRRQLTPYAQRMERVLRENADSLQASLRPHADELK 187
+ Q+ LE Q + ++S +AE+L+ ++ ++ R A+ R A+E+
Sbjct: 2339 TQGFQRTLEAER-QRQLEMSAEAERLKLRVAEMSRAQAR-----AEEDAQRFRKQAEEIG 2392
Query: 188 AKIDQN--VEELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQM 245
K+ + + K L + + + D E LR ++A ++ +EKL Q E Q+
Sbjct: 2393 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE-KEKL--QQEAKLLQL 2449
Query: 246 KKNAEELKARISASAEELRQRLAPLAEDV---RGNLRGNTEGLQKSLAELGGHLDQQVEE 302
K +EE++ + E+L Q L + + +L +++ A+L +V +
Sbjct: 2450 K--SEEMQ---TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAK 2504
Query: 303 FRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDKVNSFFSTFKEKE 362
++ E + QQMEQ RQ+L ++ +E+ R + + E+
Sbjct: 2505 AQQLREE-----QQRQQQQMEQERQRL----------VASMEEARRRQHEA------EEG 2543
Query: 363 SQDKTLSLPELEQQQEQQQEQQQEQVQML 391
+ K L +LEQQ+ QQ+E E+ Q L
Sbjct: 2544 VRRKQEELQQLEQQRRQQEELLAEENQRL 2572
Score = 52.4 bits (124), Expect = 7e-07
Identities = 92/396 (23%), Positives = 166/396 (41%), Gaps = 55/396 (13%)
Query: 37 QLSNNAKEAVEHLQKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSE 96
+L+ E L + Q+L A + T G+ Q++L+ +R A +
Sbjct: 1666 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1725
Query: 97 KLKEEIGKELEELRAR---LLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVSTQAEQL 153
+ ++E+ EL ++RA LL ++ + +QRLE A + R +++ +A +L
Sbjct: 1726 QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR-ELAEEAARL 1784
Query: 154 RRQLTPYAQRMERVLRENADSLQASLRP----------HADELKAKIDQNVEELKG---- 199
R L A+R ++ E+A +A A LK + + ++E +
Sbjct: 1785 RA-LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENER 1843
Query: 200 -------------RLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQMK 246
RL A + K I++ + +LR+ A D++ + L T + +
Sbjct: 1844 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK-----ASDSELERQKGLVEDTLRQR 1898
Query: 247 KNAEELKARISASAEELRQRLAPLAEDVRGNLRGNTEGL--QKSLAELGGHLDQQV--EE 302
+ EE + AS E+ A L ++ G +R N E K AEL +Q+ EE
Sbjct: 1899 RQVEEEILALKASFEKAAAGKAELELEL-GRIRSNAEDTLRSKEQAELEAARQRQLAAEE 1957
Query: 303 FRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLE--KDLRDKVNSFFS---- 356
RRR E E K+L + E RQ+ +VE + +E + LR++ +
Sbjct: 1958 ERRRREAE-ERVQKSLAAEEEAARQRKAA-LEEVERLKAKVEEARRLRERAEQESARQLQ 2015
Query: 357 -----TFKEKESQDKTLSLPELEQQQEQQQEQQQEQ 387
K ++++K + +++QE QQ QQEQ
Sbjct: 2016 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2051
Score = 50.4 bits (119), Expect = 3e-06
Identities = 81/355 (22%), Positives = 145/355 (40%), Gaps = 43/355 (12%)
Query: 2 FLKAVVLTLALVAVAGARAEVSADQVATVMWDYFSQLSNNAKEAVEHLQKSELTQQLNAL 61
FL+ + VA AR V+A + A + QL+ L + L +++ A+
Sbjct: 2243 FLQEEAEKMKQVAEEAARLSVAAQEAARLR-----QLAEEDLAQQRALAEKMLKEKMQAV 2297
Query: 62 FQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSEKLKEEIGKE-------LEELRARLL 114
+ + QK+L A E RL +D E++ +++ +E LE R R L
Sbjct: 2298 QEATRLKAEAELLQQQKEL---AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2354
Query: 115 PHANEVSQ---KIGDNLRELQQRLEPYADQLRTQVSTQAEQLRR------QLTPYAQRME 165
+ E + ++ + R Q R E A + R Q E+L R + Q +E
Sbjct: 2355 EMSAEAERLKLRVAEMSRA-QARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2413
Query: 166 RVLRENADSLQASLRPHADELKAKIDQNVEELKGRLTPYADEFKVKIDQTVEELRRSLAP 225
+ R+ +D LR EL+ + ++ +E K + V+ +Q ++E +
Sbjct: 2414 -IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2472
Query: 226 YAQDTQEKLNHQ---------LEGLTFQMKKNAEELKA---RISASAEELRQRLAPLAED 273
+ + L + LE L A++L+ R E+ RQRL E+
Sbjct: 2473 FLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE 2532
Query: 274 VRGNLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQK 328
R EG+++ EL QQ+E+ RR+ E N+ L +Q++ L ++
Sbjct: 2533 ARRRQHEAEEGVRRKQEEL-----QQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2582
Score = 48.9 bits (115), Expect = 8e-06
Identities = 67/312 (21%), Positives = 137/312 (43%), Gaps = 59/312 (18%)
Query: 89 ERLAKDSEKLKEEIGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVST 148
++ A++ E+L E + LE+ R HA +Q + +ELQQR++ + R + +
Sbjct: 1331 QQRAEERERLAE-VEAALEKQRQLAEAHAQAKAQAERE-AKELQQRMQEEVVR-REEAAV 1387
Query: 149 QAEQLRRQLTPYAQRMERVLRENADS-LQASLRPH--ADELKAKIDQNV----------E 195
A+Q +R + Q+ LR+++++ +QA R A+ + +I++ + E
Sbjct: 1388 DAQQQKRSIQEELQQ----LRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE 1443
Query: 196 ELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAE-ELKA 254
+G + + ++ + R+ AQ+ E+L Q++ + Q K+ AE EL +
Sbjct: 1444 RQRGGAEGELQALRARAEEAEAQKRQ-----AQEEAERLRRQVQDES-QRKRQAEVELAS 1497
Query: 255 RISASAEELRQRLAPLAEDVRGNLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENF 314
R+ A AE R++ Q++L Q +EE R + E
Sbjct: 1498 RVKAEAEAAREK-------------------QRAL--------QALEELRLQAEEAERRL 1530
Query: 315 NKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDKVNSFFSTFKEKESQDKTLSLPELE 374
+A V++ Q++ L E L +K E+ Q++ +++ +L
Sbjct: 1531 RQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL-----ERSLQEEHVAVAQLR 1585
Query: 375 QQQEQQQEQQQE 386
++ E++ +QQ E
Sbjct: 1586 EEAERRAQQQAE 1597
Score = 48.1 bits (113), Expect = 1e-05
Identities = 86/364 (23%), Positives = 147/364 (40%), Gaps = 31/364 (8%)
Query: 44 EAVEHLQKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSE--KLKEE 101
EA + +E +L AL ++ + D ++ L E+LA E +LK E
Sbjct: 1770 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE 1829
Query: 102 IGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVSTQAEQLRRQLTPYA 161
L+E A NE +++ ++ ++RLE A Q + + + QLR+
Sbjct: 1830 AEIALKEKEAE-----NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1884
Query: 162 QR----MERVLRENADSLQASLRPHADELKAKIDQNVEELK-GRLTPYADEFKVKIDQTV 216
+R +E LR+ + L A KA + EL+ GR+ A++ +Q
Sbjct: 1885 ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 1944
Query: 217 EELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELKARISASAEELRQRLAPLAEDVRG 276
E R A++ + + + Q AEE AR +A E +RL E+ R
Sbjct: 1945 LEAARQRQLAAEEERRRREAEER---VQKSLAAEEEAARQRKAALEEVERLKAKVEEAR- 2000
Query: 277 NLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENF-----NKALVQQMEQLRQKLGP 331
LR E Q+S +L L Q+ + R + E F + L Q ++Q + L
Sbjct: 2001 RLRERAE--QESARQL--QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2056
Query: 332 HAGDVEGHLSFLEKDLRDKVNSFFSTFKEKESQDKTLSLPELEQQQEQQQEQQQEQVQML 391
G+ E E+ +V + E+E+ + E E+ ++ +EQ Q + Q
Sbjct: 2057 LRGEAEAARRAAEEAEEARVQA------EREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2110
Query: 392 APLE 395
A E
Sbjct: 2111 AAAE 2114
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 65.1 bits (157), Expect = 1e-10
Identities = 84/353 (23%), Positives = 146/353 (41%), Gaps = 58/353 (16%)
Query: 77 QKKLVPFATELHERLAKDSEKLKEEIGKELEELRARLLPHANEVSQKIGDNLRELQQRLE 136
QK+ E H++ A+ + + K ++ +EL LR + L + + + L+ L+
Sbjct: 2145 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ-LEETDHQKNLLDEELQRLKAEAT 2203
Query: 137 PYADQLRTQVSTQAEQLRRQLTPYAQRMERVLREN-------ADSLQASLRPHADELKAK 189
A Q R+QV + +R Q+ ++ R+ EN D+ Q L+ A+++K
Sbjct: 2204 EAARQ-RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK-- 2260
Query: 190 IDQNVEELKGRLTPYADEFKVKIDQTVEE--------LRRSLAPYAQDTQEKLNHQLEG- 240
V E RL+ A E ++ Q EE + L Q QE + E
Sbjct: 2261 ---QVAEEAARLSVAAQE-AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE 2316
Query: 241 LTFQMKKNAEELKARISASAEELRQRLAPLAEDVRGNLR----------GNTEGLQKSLA 290
L Q K+ A+E R+ E++ Q+LA + + L E L+ +A
Sbjct: 2317 LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2376
Query: 291 ELG---GHLDQQVEEFRRRVEPYGENFNK---------ALVQQMEQLRQKLGPHAGDVEG 338
E+ ++ + FR++ E GE ++ LVQ +E RQ+ A +
Sbjct: 2377 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2436
Query: 339 HLSFLEKDLRDKVNSFFSTFKEKESQDKTLSLPELEQQQEQQQEQQQEQVQML 391
++ LE++ KEK Q+ L + E+ Q QQEQ ++ Q L
Sbjct: 2437 AIAELERE------------KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL 2477
Score = 61.6 bits (148), Expect = 1e-09
Identities = 94/406 (23%), Positives = 174/406 (42%), Gaps = 63/406 (15%)
Query: 36 SQLSNNAKEAVEHL-QKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKD 94
+++ + K A + L QK+++ Q+L L + +L E + L ++L E E A+
Sbjct: 2151 AEMEKHKKFAEQTLRQKAQVEQELTTL-RLQLEETDHQKNLLDEELQRLKAEATEA-ARQ 2208
Query: 95 SEKLKEEIG------KELEELRARLLPHANEVSQKIGDN----LRELQQRLEPYADQL-R 143
+++EE+ +EL +L+AR+ + + DN L+E ++++ A++ R
Sbjct: 2209 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR 2268
Query: 144 TQVSTQAEQLRRQLTPYAQRMERVLRENADSLQASLRPHADELKAKIDQNVEELKGRLTP 203
V+ Q RQL +R L E + A LKA+ EL +
Sbjct: 2269 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA-----ELLQQQKE 2323
Query: 204 YADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELKARIS------ 257
A E ++ + E++ + LA Q Q L + + +M AE LK R++
Sbjct: 2324 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR-QLEMSAEAERLKLRVAEMSRAQ 2382
Query: 258 ASAEELRQRLAPLAEDVRGNLRG------------------------NTEGLQKSLAELG 293
A AEE QR AE++ L + E L++++AEL
Sbjct: 2383 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2442
Query: 294 GH---LDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDK 350
L Q+ + + + E + L+Q+ + L+Q + F+E++ + K
Sbjct: 2443 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE-KAK 2501
Query: 351 VNSFFSTFKEKESQDKTLSLPEL-EQQQEQQQEQQQEQVQMLAPLE 395
+ F QD+ +L E+QQ QQQ+ +QE+ +++A +E
Sbjct: 2502 LEQLF--------QDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2539
Score = 52.8 bits (125), Expect = 5e-07
Identities = 87/389 (22%), Positives = 173/389 (44%), Gaps = 54/389 (13%)
Query: 19 RAEVSADQVATVMWD------YFSQLSNNAKEAVEHLQKSELTQQ----LNALFQDKLGE 68
+A + A+ A ++ D + + + K+ E + + Q L L ++ L +
Sbjct: 2230 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2289
Query: 69 VNTYAGDLQKKLVPFATELHERLAKDSEKLKEEIGKELEELRARLLPHANE-VSQKIGDN 127
A + K+ + E RL ++E L+++ KEL + +AR L E ++Q++ +
Sbjct: 2290 QRALAEKMLKEKMQAVQEA-TRLKAEAELLQQQ--KELAQEQARRLQEDKEQMAQQLAEE 2346
Query: 128 LRELQQRLEPYADQLRTQVSTQAEQLRRQLTPYAQRMERVLRENADSLQASLRPHADELK 187
+ Q+ LE Q + ++S +AE+L+ ++ ++ R A+ R A+E+
Sbjct: 2347 TQGFQRTLEAER-QRQLEMSAEAERLKLRVAEMSRAQAR-----AEEDAQRFRKQAEEIG 2400
Query: 188 AKIDQN--VEELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQM 245
K+ + + K L + + + D E LR ++A ++ +EKL Q E Q+
Sbjct: 2401 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE-KEKL--QQEAKLLQL 2457
Query: 246 KKNAEELKARISASAEELRQRLAPLAEDV---RGNLRGNTEGLQKSLAELGGHLDQQVEE 302
K +EE++ + E+L Q L + + +L +++ A+L +V +
Sbjct: 2458 K--SEEMQ---TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAK 2512
Query: 303 FRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDKVNSFFSTFKEKE 362
++ E + QQMEQ RQ+L ++ +E+ R + + E+
Sbjct: 2513 AQQLREE-----QQRQQQQMEQERQRL----------VASMEEARRRQHEA------EEG 2551
Query: 363 SQDKTLSLPELEQQQEQQQEQQQEQVQML 391
+ K L +LEQQ+ QQ+E E+ Q L
Sbjct: 2552 VRRKQEELQQLEQQRRQQEELLAEENQRL 2580
Score = 52.4 bits (124), Expect = 7e-07
Identities = 92/396 (23%), Positives = 166/396 (41%), Gaps = 55/396 (13%)
Query: 37 QLSNNAKEAVEHLQKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSE 96
+L+ E L + Q+L A + T G+ Q++L+ +R A +
Sbjct: 1674 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1733
Query: 97 KLKEEIGKELEELRAR---LLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVSTQAEQL 153
+ ++E+ EL ++RA LL ++ + +QRLE A + R +++ +A +L
Sbjct: 1734 QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR-ELAEEAARL 1792
Query: 154 RRQLTPYAQRMERVLRENADSLQASLRP----------HADELKAKIDQNVEELKG---- 199
R L A+R ++ E+A +A A LK + + ++E +
Sbjct: 1793 RA-LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENER 1851
Query: 200 -------------RLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQMK 246
RL A + K I++ + +LR+ A D++ + L T + +
Sbjct: 1852 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK-----ASDSELERQKGLVEDTLRQR 1906
Query: 247 KNAEELKARISASAEELRQRLAPLAEDVRGNLRGNTEGL--QKSLAELGGHLDQQV--EE 302
+ EE + AS E+ A L ++ G +R N E K AEL +Q+ EE
Sbjct: 1907 RQVEEEILALKASFEKAAAGKAELELEL-GRIRSNAEDTLRSKEQAELEAARQRQLAAEE 1965
Query: 303 FRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLE--KDLRDKVNSFFS---- 356
RRR E E K+L + E RQ+ +VE + +E + LR++ +
Sbjct: 1966 ERRRREAE-ERVQKSLAAEEEAARQRKAA-LEEVERLKAKVEEARRLRERAEQESARQLQ 2023
Query: 357 -----TFKEKESQDKTLSLPELEQQQEQQQEQQQEQ 387
K ++++K + +++QE QQ QQEQ
Sbjct: 2024 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2059
Score = 50.4 bits (119), Expect = 3e-06
Identities = 81/355 (22%), Positives = 145/355 (40%), Gaps = 43/355 (12%)
Query: 2 FLKAVVLTLALVAVAGARAEVSADQVATVMWDYFSQLSNNAKEAVEHLQKSELTQQLNAL 61
FL+ + VA AR V+A + A + QL+ L + L +++ A+
Sbjct: 2251 FLQEEAEKMKQVAEEAARLSVAAQEAARLR-----QLAEEDLAQQRALAEKMLKEKMQAV 2305
Query: 62 FQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSEKLKEEIGKE-------LEELRARLL 114
+ + QK+L A E RL +D E++ +++ +E LE R R L
Sbjct: 2306 QEATRLKAEAELLQQQKEL---AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2362
Query: 115 PHANEVSQ---KIGDNLRELQQRLEPYADQLRTQVSTQAEQLRR------QLTPYAQRME 165
+ E + ++ + R Q R E A + R Q E+L R + Q +E
Sbjct: 2363 EMSAEAERLKLRVAEMSRA-QARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2421
Query: 166 RVLRENADSLQASLRPHADELKAKIDQNVEELKGRLTPYADEFKVKIDQTVEELRRSLAP 225
+ R+ +D LR EL+ + ++ +E K + V+ +Q ++E +
Sbjct: 2422 -IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2480
Query: 226 YAQDTQEKLNHQ---------LEGLTFQMKKNAEELKA---RISASAEELRQRLAPLAED 273
+ + L + LE L A++L+ R E+ RQRL E+
Sbjct: 2481 FLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE 2540
Query: 274 VRGNLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQK 328
R EG+++ EL QQ+E+ RR+ E N+ L +Q++ L ++
Sbjct: 2541 ARRRQHEAEEGVRRKQEEL-----QQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2590
Score = 48.9 bits (115), Expect = 8e-06
Identities = 67/312 (21%), Positives = 137/312 (43%), Gaps = 59/312 (18%)
Query: 89 ERLAKDSEKLKEEIGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVST 148
++ A++ E+L E + LE+ R HA +Q + +ELQQR++ + R + +
Sbjct: 1339 QQRAEERERLAE-VEAALEKQRQLAEAHAQAKAQAERE-AKELQQRMQEEVVR-REEAAV 1395
Query: 149 QAEQLRRQLTPYAQRMERVLRENADS-LQASLRPH--ADELKAKIDQNV----------E 195
A+Q +R + Q+ LR+++++ +QA R A+ + +I++ + E
Sbjct: 1396 DAQQQKRSIQEELQQ----LRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE 1451
Query: 196 ELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAE-ELKA 254
+G + + ++ + R+ AQ+ E+L Q++ + Q K+ AE EL +
Sbjct: 1452 RQRGGAEGELQALRARAEEAEAQKRQ-----AQEEAERLRRQVQDES-QRKRQAEVELAS 1505
Query: 255 RISASAEELRQRLAPLAEDVRGNLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENF 314
R+ A AE R++ Q++L Q +EE R + E
Sbjct: 1506 RVKAEAEAAREK-------------------QRAL--------QALEELRLQAEEAERRL 1538
Query: 315 NKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDKVNSFFSTFKEKESQDKTLSLPELE 374
+A V++ Q++ L E L +K E+ Q++ +++ +L
Sbjct: 1539 RQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL-----ERSLQEEHVAVAQLR 1593
Query: 375 QQQEQQQEQQQE 386
++ E++ +QQ E
Sbjct: 1594 EEAERRAQQQAE 1605
Score = 48.1 bits (113), Expect = 1e-05
Identities = 86/364 (23%), Positives = 147/364 (40%), Gaps = 31/364 (8%)
Query: 44 EAVEHLQKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSE--KLKEE 101
EA + +E +L AL ++ + D ++ L E+LA E +LK E
Sbjct: 1778 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE 1837
Query: 102 IGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVSTQAEQLRRQLTPYA 161
L+E A NE +++ ++ ++RLE A Q + + + QLR+
Sbjct: 1838 AEIALKEKEAE-----NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1892
Query: 162 QR----MERVLRENADSLQASLRPHADELKAKIDQNVEELK-GRLTPYADEFKVKIDQTV 216
+R +E LR+ + L A KA + EL+ GR+ A++ +Q
Sbjct: 1893 ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 1952
Query: 217 EELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELKARISASAEELRQRLAPLAEDVRG 276
E R A++ + + + Q AEE AR +A E +RL E+ R
Sbjct: 1953 LEAARQRQLAAEEERRRREAEER---VQKSLAAEEEAARQRKAALEEVERLKAKVEEAR- 2008
Query: 277 NLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENF-----NKALVQQMEQLRQKLGP 331
LR E Q+S +L L Q+ + R + E F + L Q ++Q + L
Sbjct: 2009 RLRERAE--QESARQL--QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2064
Query: 332 HAGDVEGHLSFLEKDLRDKVNSFFSTFKEKESQDKTLSLPELEQQQEQQQEQQQEQVQML 391
G+ E E+ +V + E+E+ + E E+ ++ +EQ Q + Q
Sbjct: 2065 LRGEAEAARRAAEEAEEARVQA------EREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2118
Query: 392 APLE 395
A E
Sbjct: 2119 AAAE 2122
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 65.1 bits (157), Expect = 1e-10
Identities = 84/353 (23%), Positives = 146/353 (41%), Gaps = 58/353 (16%)
Query: 77 QKKLVPFATELHERLAKDSEKLKEEIGKELEELRARLLPHANEVSQKIGDNLRELQQRLE 136
QK+ E H++ A+ + + K ++ +EL LR + L + + + L+ L+
Sbjct: 2186 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ-LEETDHQKNLLDEELQRLKAEAT 2244
Query: 137 PYADQLRTQVSTQAEQLRRQLTPYAQRMERVLREN-------ADSLQASLRPHADELKAK 189
A Q R+QV + +R Q+ ++ R+ EN D+ Q L+ A+++K
Sbjct: 2245 EAARQ-RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK-- 2301
Query: 190 IDQNVEELKGRLTPYADEFKVKIDQTVEE--------LRRSLAPYAQDTQEKLNHQLEG- 240
V E RL+ A E ++ Q EE + L Q QE + E
Sbjct: 2302 ---QVAEEAARLSVAAQE-AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE 2357
Query: 241 LTFQMKKNAEELKARISASAEELRQRLAPLAEDVRGNLR----------GNTEGLQKSLA 290
L Q K+ A+E R+ E++ Q+LA + + L E L+ +A
Sbjct: 2358 LLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2417
Query: 291 ELG---GHLDQQVEEFRRRVEPYGENFNK---------ALVQQMEQLRQKLGPHAGDVEG 338
E+ ++ + FR++ E GE ++ LVQ +E RQ+ A +
Sbjct: 2418 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2477
Query: 339 HLSFLEKDLRDKVNSFFSTFKEKESQDKTLSLPELEQQQEQQQEQQQEQVQML 391
++ LE++ KEK Q+ L + E+ Q QQEQ ++ Q L
Sbjct: 2478 AIAELERE------------KEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL 2518
Score = 61.6 bits (148), Expect = 1e-09
Identities = 94/406 (23%), Positives = 174/406 (42%), Gaps = 63/406 (15%)
Query: 36 SQLSNNAKEAVEHL-QKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKD 94
+++ + K A + L QK+++ Q+L L + +L E + L ++L E E A+
Sbjct: 2192 AEMEKHKKFAEQTLRQKAQVEQELTTL-RLQLEETDHQKNLLDEELQRLKAEATEA-ARQ 2249
Query: 95 SEKLKEEIG------KELEELRARLLPHANEVSQKIGDN----LRELQQRLEPYADQL-R 143
+++EE+ +EL +L+AR+ + + DN L+E ++++ A++ R
Sbjct: 2250 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR 2309
Query: 144 TQVSTQAEQLRRQLTPYAQRMERVLRENADSLQASLRPHADELKAKIDQNVEELKGRLTP 203
V+ Q RQL +R L E + A LKA+ EL +
Sbjct: 2310 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA-----ELLQQQKE 2364
Query: 204 YADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELKARIS------ 257
A E ++ + E++ + LA Q Q L + + +M AE LK R++
Sbjct: 2365 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR-QLEMSAEAERLKLRVAEMSRAQ 2423
Query: 258 ASAEELRQRLAPLAEDVRGNLRG------------------------NTEGLQKSLAELG 293
A AEE QR AE++ L + E L++++AEL
Sbjct: 2424 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2483
Query: 294 GH---LDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDK 350
L Q+ + + + E + L+Q+ + L+Q + F+E++ + K
Sbjct: 2484 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE-KAK 2542
Query: 351 VNSFFSTFKEKESQDKTLSLPEL-EQQQEQQQEQQQEQVQMLAPLE 395
+ F QD+ +L E+QQ QQQ+ +QE+ +++A +E
Sbjct: 2543 LEQLF--------QDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2580
Score = 52.8 bits (125), Expect = 5e-07
Identities = 87/389 (22%), Positives = 173/389 (44%), Gaps = 54/389 (13%)
Query: 19 RAEVSADQVATVMWD------YFSQLSNNAKEAVEHLQKSELTQQ----LNALFQDKLGE 68
+A + A+ A ++ D + + + K+ E + + Q L L ++ L +
Sbjct: 2271 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2330
Query: 69 VNTYAGDLQKKLVPFATELHERLAKDSEKLKEEIGKELEELRARLLPHANE-VSQKIGDN 127
A + K+ + E RL ++E L+++ KEL + +AR L E ++Q++ +
Sbjct: 2331 QRALAEKMLKEKMQAVQEA-TRLKAEAELLQQQ--KELAQEQARRLQEDKEQMAQQLAEE 2387
Query: 128 LRELQQRLEPYADQLRTQVSTQAEQLRRQLTPYAQRMERVLRENADSLQASLRPHADELK 187
+ Q+ LE Q + ++S +AE+L+ ++ ++ R A+ R A+E+
Sbjct: 2388 TQGFQRTLEAER-QRQLEMSAEAERLKLRVAEMSRAQAR-----AEEDAQRFRKQAEEIG 2441
Query: 188 AKIDQN--VEELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQM 245
K+ + + K L + + + D E LR ++A ++ +EKL Q E Q+
Sbjct: 2442 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE-KEKL--QQEAKLLQL 2498
Query: 246 KKNAEELKARISASAEELRQRLAPLAEDV---RGNLRGNTEGLQKSLAELGGHLDQQVEE 302
K +EE++ + E+L Q L + + +L +++ A+L +V +
Sbjct: 2499 K--SEEMQ---TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAK 2553
Query: 303 FRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDKVNSFFSTFKEKE 362
++ E + QQMEQ RQ+L ++ +E+ R + + E+
Sbjct: 2554 AQQLREE-----QQRQQQQMEQERQRL----------VASMEEARRRQHEA------EEG 2592
Query: 363 SQDKTLSLPELEQQQEQQQEQQQEQVQML 391
+ K L +LEQQ+ QQ+E E+ Q L
Sbjct: 2593 VRRKQEELQQLEQQRRQQEELLAEENQRL 2621
Score = 52.4 bits (124), Expect = 7e-07
Identities = 92/396 (23%), Positives = 166/396 (41%), Gaps = 55/396 (13%)
Query: 37 QLSNNAKEAVEHLQKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSE 96
+L+ E L + Q+L A + T G+ Q++L+ +R A +
Sbjct: 1715 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1774
Query: 97 KLKEEIGKELEELRAR---LLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVSTQAEQL 153
+ ++E+ EL ++RA LL ++ + +QRLE A + R +++ +A +L
Sbjct: 1775 QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR-ELAEEAARL 1833
Query: 154 RRQLTPYAQRMERVLRENADSLQASLRP----------HADELKAKIDQNVEELKG---- 199
R L A+R ++ E+A +A A LK + + ++E +
Sbjct: 1834 RA-LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENER 1892
Query: 200 -------------RLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQMK 246
RL A + K I++ + +LR+ A D++ + L T + +
Sbjct: 1893 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK-----ASDSELERQKGLVEDTLRQR 1947
Query: 247 KNAEELKARISASAEELRQRLAPLAEDVRGNLRGNTEGL--QKSLAELGGHLDQQV--EE 302
+ EE + AS E+ A L ++ G +R N E K AEL +Q+ EE
Sbjct: 1948 RQVEEEILALKASFEKAAAGKAELELEL-GRIRSNAEDTLRSKEQAELEAARQRQLAAEE 2006
Query: 303 FRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLE--KDLRDKVNSFFS---- 356
RRR E E K+L + E RQ+ +VE + +E + LR++ +
Sbjct: 2007 ERRRREAE-ERVQKSLAAEEEAARQRKAA-LEEVERLKAKVEEARRLRERAEQESARQLQ 2064
Query: 357 -----TFKEKESQDKTLSLPELEQQQEQQQEQQQEQ 387
K ++++K + +++QE QQ QQEQ
Sbjct: 2065 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2100
Score = 50.4 bits (119), Expect = 3e-06
Identities = 81/355 (22%), Positives = 145/355 (40%), Gaps = 43/355 (12%)
Query: 2 FLKAVVLTLALVAVAGARAEVSADQVATVMWDYFSQLSNNAKEAVEHLQKSELTQQLNAL 61
FL+ + VA AR V+A + A + QL+ L + L +++ A+
Sbjct: 2292 FLQEEAEKMKQVAEEAARLSVAAQEAARLR-----QLAEEDLAQQRALAEKMLKEKMQAV 2346
Query: 62 FQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSEKLKEEIGKE-------LEELRARLL 114
+ + QK+L A E RL +D E++ +++ +E LE R R L
Sbjct: 2347 QEATRLKAEAELLQQQKEL---AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2403
Query: 115 PHANEVSQ---KIGDNLRELQQRLEPYADQLRTQVSTQAEQLRR------QLTPYAQRME 165
+ E + ++ + R Q R E A + R Q E+L R + Q +E
Sbjct: 2404 EMSAEAERLKLRVAEMSRA-QARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2462
Query: 166 RVLRENADSLQASLRPHADELKAKIDQNVEELKGRLTPYADEFKVKIDQTVEELRRSLAP 225
+ R+ +D LR EL+ + ++ +E K + V+ +Q ++E +
Sbjct: 2463 -IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2521
Query: 226 YAQDTQEKLNHQ---------LEGLTFQMKKNAEELKA---RISASAEELRQRLAPLAED 273
+ + L + LE L A++L+ R E+ RQRL E+
Sbjct: 2522 FLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE 2581
Query: 274 VRGNLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQK 328
R EG+++ EL QQ+E+ RR+ E N+ L +Q++ L ++
Sbjct: 2582 ARRRQHEAEEGVRRKQEEL-----QQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2631
Score = 48.9 bits (115), Expect = 8e-06
Identities = 67/312 (21%), Positives = 137/312 (43%), Gaps = 59/312 (18%)
Query: 89 ERLAKDSEKLKEEIGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVST 148
++ A++ E+L E + LE+ R HA +Q + +ELQQR++ + R + +
Sbjct: 1380 QQRAEERERLAE-VEAALEKQRQLAEAHAQAKAQAERE-AKELQQRMQEEVVR-REEAAV 1436
Query: 149 QAEQLRRQLTPYAQRMERVLRENADS-LQASLRPH--ADELKAKIDQNV----------E 195
A+Q +R + Q+ LR+++++ +QA R A+ + +I++ + E
Sbjct: 1437 DAQQQKRSIQEELQQ----LRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE 1492
Query: 196 ELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAE-ELKA 254
+G + + ++ + R+ AQ+ E+L Q++ + Q K+ AE EL +
Sbjct: 1493 RQRGGAEGELQALRARAEEAEAQKRQ-----AQEEAERLRRQVQDES-QRKRQAEVELAS 1546
Query: 255 RISASAEELRQRLAPLAEDVRGNLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENF 314
R+ A AE R++ Q++L Q +EE R + E
Sbjct: 1547 RVKAEAEAAREK-------------------QRAL--------QALEELRLQAEEAERRL 1579
Query: 315 NKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDKVNSFFSTFKEKESQDKTLSLPELE 374
+A V++ Q++ L E L +K E+ Q++ +++ +L
Sbjct: 1580 RQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL-----ERSLQEEHVAVAQLR 1634
Query: 375 QQQEQQQEQQQE 386
++ E++ +QQ E
Sbjct: 1635 EEAERRAQQQAE 1646
Score = 48.1 bits (113), Expect = 1e-05
Identities = 86/364 (23%), Positives = 147/364 (40%), Gaps = 31/364 (8%)
Query: 44 EAVEHLQKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSE--KLKEE 101
EA + +E +L AL ++ + D ++ L E+LA E +LK E
Sbjct: 1819 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE 1878
Query: 102 IGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVSTQAEQLRRQLTPYA 161
L+E A NE +++ ++ ++RLE A Q + + + QLR+
Sbjct: 1879 AEIALKEKEAE-----NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1933
Query: 162 QR----MERVLRENADSLQASLRPHADELKAKIDQNVEELK-GRLTPYADEFKVKIDQTV 216
+R +E LR+ + L A KA + EL+ GR+ A++ +Q
Sbjct: 1934 ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 1993
Query: 217 EELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELKARISASAEELRQRLAPLAEDVRG 276
E R A++ + + + Q AEE AR +A E +RL E+ R
Sbjct: 1994 LEAARQRQLAAEEERRRREAEER---VQKSLAAEEEAARQRKAALEEVERLKAKVEEAR- 2049
Query: 277 NLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENF-----NKALVQQMEQLRQKLGP 331
LR E Q+S +L L Q+ + R + E F + L Q ++Q + L
Sbjct: 2050 RLRERAE--QESARQL--QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2105
Query: 332 HAGDVEGHLSFLEKDLRDKVNSFFSTFKEKESQDKTLSLPELEQQQEQQQEQQQEQVQML 391
G+ E E+ +V + E+E+ + E E+ ++ +EQ Q + Q
Sbjct: 2106 LRGEAEAARRAAEEAEEARVQA------EREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2159
Query: 392 APLE 395
A E
Sbjct: 2160 AAAE 2163
>gi|115648142 centrosomal protein 164kDa [Homo sapiens]
Length = 1460
Score = 60.1 bits (144), Expect = 3e-09
Identities = 71/364 (19%), Positives = 157/364 (43%), Gaps = 25/364 (6%)
Query: 51 KSELTQQLNA-LFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSEKLKEEIGKELEEL 109
K E QQL L Q++ E+ ++ L L + + ++ +++EE + L L
Sbjct: 614 KQEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEARMREEESQRLSWL 673
Query: 110 RARLLPHANEVSQKIGDNLR-ELQQRLEPYADQLRTQVSTQAEQLRRQLTPYAQRMERVL 168
RA++ +Q D +R E + L+ ++L +Q + L ++ ++++ +
Sbjct: 674 RAQV----QSSTQADEDQIRAEQEASLQKLREELESQQKAERASLEQKNRQMLEQLKEEI 729
Query: 169 RENADSLQASLRPHADELKAKIDQNVE-ELKGRLTPYADEFKVKIDQTVEELR------- 220
+ S QA+L ++ ++ + +E E K + E ++++ L
Sbjct: 730 EASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAELERLCSSLEAKHREVV 789
Query: 221 RSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELKARISASAEELRQRLAPLAEDVRGNLRG 280
SL Q+ Q+K QL+ Q++ + ++ EL L ++V G
Sbjct: 790 SSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHER 849
Query: 281 NTEGLQKSLAELGGHLDQQ--VEEFRRRVEPYG------ENFNKALVQQMEQLRQKLGPH 332
+ +++ ++ +Q EE ++R E G E +A +++E +RQ+
Sbjct: 850 RLDKMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGELERLQRAHERELETVRQEQHKR 909
Query: 333 AGDVEGHLSFLEKDLRDKVNSFFSTFKEKESQDKTLSLPELEQQQEQQQEQQQEQVQMLA 392
D+ E+ L+D + K+ +++ L+L E++++ ++++QQ VQ
Sbjct: 910 LEDLRRRHREQERKLQDLELDLETRAKDVKAR---LALLEVQEETARREKQQLLDVQRQV 966
Query: 393 PLES 396
L+S
Sbjct: 967 ALKS 970
Score = 55.5 bits (132), Expect = 8e-08
Identities = 70/311 (22%), Positives = 125/311 (40%), Gaps = 33/311 (10%)
Query: 96 EKLKEEIGKELEELRARLLP----HANEVSQKIGDNLRE-LQQRLEPYADQLRTQVSTQA 150
E+L E K +EE A++L H E Q+ LRE L Q E +L Q
Sbjct: 585 EQLSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILRLHQQKEQSL 644
Query: 151 EQLRRQLTPYAQRMERVLRENADS--------LQASLRPHADELKAKIDQNVEELKGRLT 202
LR +L + E +RE +Q+S + D+++A+ + ++++L+ L
Sbjct: 645 SSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELE 704
Query: 203 PYADEFKVKIDQT----VEELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAE-ELKARIS 257
+ ++Q +E+L+ + + Q LN E Q+++ E E K ++
Sbjct: 705 SQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGERKEAVA 764
Query: 258 ASAEELRQRLAPLAEDVRGNLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENFNKA 317
+E L L + R LQK + E QQ EE K
Sbjct: 765 TLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEA-----QQKEE---------AQLQKC 810
Query: 318 LVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDKVNSFFSTFKEKESQDKTLSLPELEQQQ 377
L Q ++ QK H E LS L ++ R +V +K ++ + + +Q
Sbjct: 811 LGQVEHRVHQK-SYHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQY 869
Query: 378 EQQQEQQQEQV 388
E ++ +Q+ ++
Sbjct: 870 EAEERKQRAEL 880
Score = 49.3 bits (116), Expect = 6e-06
Identities = 78/365 (21%), Positives = 143/365 (39%), Gaps = 58/365 (15%)
Query: 37 QLSNNAKEAVEHLQKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSE 96
Q+ KE +E +KSE LNA + L ++ +K+ V
Sbjct: 720 QMLEQLKEEIEASEKSEQAA-LNAAKEKALQQLREQLEGERKEAVA-------------- 764
Query: 97 KLKEEIGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVSTQAEQLRRQ 156
L++E ELE L + L EV + ++E QQ+ E + QV + Q
Sbjct: 765 TLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYH 824
Query: 157 LTPYAQRMERVLRENADSLQASLRPHADELK-------AKIDQNVE--------ELKGRL 201
+ Y + +LRE ++ D++K AK + E EL G L
Sbjct: 825 VAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLGHL 884
Query: 202 TPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQ---LEGLTFQMKKNAEELKARISA 258
T + + ++ +E +R+ +D + + Q L+ L ++ A+++KAR++
Sbjct: 885 TGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLA- 943
Query: 259 SAEELRQRLAPLAEDVRGNLRGNTEGLQKSLA---ELGGHLDQQVEEFRRRVEPYGENFN 315
L + E+ + +Q+ +A E QQ+EE ++ +
Sbjct: 944 --------LLEVQEETARREKQQLLDVQRQVALKSEEATATHQQLEEAQKE--------H 987
Query: 316 KALVQQMEQLRQ---KLGPHAGDVEGHLSFLEKDLRDKVNSFFSTFKEKESQDKTLSLPE 372
L+Q +QLR+ +L +E + L+ + F S E E+Q K L E
Sbjct: 988 THLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSL--EAEAQKKQHLLRE 1045
Query: 373 LEQQQ 377
+ ++
Sbjct: 1046 VTVEE 1050
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 60.1 bits (144), Expect = 3e-09
Identities = 85/378 (22%), Positives = 166/378 (43%), Gaps = 44/378 (11%)
Query: 39 SNNAKEAVEHLQKSE--LTQQLNALFQDKLGE--VNTYAGDLQKKLVPFATELHERLAKD 94
+ N K+ E L+ SE L+QQ +L ++ G+ + T +Q L TE +RL+
Sbjct: 781 AENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQ 840
Query: 95 SEKLKEEIG---KELEE-----------LRARLLPHANEVSQK--IGDNLRELQQRLEPY 138
EKL+ EI K+LE L +LL ++ + + N +EL + +
Sbjct: 841 IEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKE 900
Query: 139 ADQLRTQVSTQAEQLRRQLTPYAQRMERVLRENADSLQASLRP---HADELKAKID---Q 192
L+ +S Q+ Q + + + +E+ D L + LR ++LK ++
Sbjct: 901 IATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTS 960
Query: 193 NVEELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEEL 252
NVE+ + +T + K Q EE+R+++ +++ E QLE +++K +EL
Sbjct: 961 NVEQYQAMVTSLEESLN-KEKQVTEEVRKNIEVRLKESAE-FQTQLEKKLMEVEKEKQEL 1018
Query: 253 KARISASAEELRQRLAPLAEDVRGNLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGE 312
+ + E + Q+L+ L + + E LQ++ L ++ RR +
Sbjct: 1019 QDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNE-----QQARRDCQEQA- 1072
Query: 313 NFNKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDKVNSFFSTFK--EKESQDKTLSL 370
K V+ + ++L HA DVE + +++V+ S + E+ +Q L
Sbjct: 1073 ---KIAVEAQNKYERELMLHAADVEA-----LQAAKEQVSKMASVRQHLEETTQKAESQL 1124
Query: 371 PELEQQQEQQQEQQQEQV 388
E + E+++ +++V
Sbjct: 1125 LECKASWEERERMLKDEV 1142
Score = 58.2 bits (139), Expect = 1e-08
Identities = 75/340 (22%), Positives = 149/340 (43%), Gaps = 26/340 (7%)
Query: 43 KEAVEHLQKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSEKLKEEI 102
K+ +E K + + + Q K + Y L +K V T+ ++L ++ +LK EI
Sbjct: 1325 KKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVH--TKRIQQLTEEIGRLKAEI 1382
Query: 103 GKELEEL--RARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVSTQAEQLRRQLTPY 160
+ L L+ E K+ +Q+ L+ ++ +V T Q+++ Y
Sbjct: 1383 ARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKT-ITQVKKIGRRY 1441
Query: 161 AQRMERVLRENADSLQASLRPHADELKAKID-QNVEELKGRLTPYADEFKVKIDQTVEEL 219
+ E + + ++ S + D + + Q ++ELK L + K ++ VE L
Sbjct: 1442 KTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSK-SLESQVENL 1500
Query: 220 RRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELKARISASAEELRQRLAPLAEDVRGNLR 279
+++L+ + + L Q L ++ + ++L+ R + E+LRQ++ E R +
Sbjct: 1501 QKTLSEKETEARN-LQEQTVQLQSELSRLRQDLQDR-TTQEEQLRQQITEKEEKTRKAI- 1557
Query: 280 GNTEGLQKSLAELGGHLDQ---QVEEFRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDV 336
+ +A L G DQ + EE ++R N AL QQ ++L ++
Sbjct: 1558 ---VAAKSKIAHLAGVKDQLTKENEELKQR--------NGALDQQKDELDVRITALKSQY 1606
Query: 337 EGHLSFLEKDLRDKVNSFFSTFKEKESQDKTLSLPELEQQ 376
EG +S LE++LR+ + E Q+ + +PE ++Q
Sbjct: 1607 EGRISRLERELREHQERHLE--QRDEPQEPSNKVPEQQRQ 1644
Score = 54.3 bits (129), Expect = 2e-07
Identities = 79/360 (21%), Positives = 150/360 (41%), Gaps = 48/360 (13%)
Query: 40 NNAKEAVEHLQK--SELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSEK 97
N K + EHLQK +L +L + + + +L + + L++ A DSE
Sbjct: 241 NGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIK--LSNLYKSAADDSEA 298
Query: 98 LKEEIGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVSTQAEQLRRQL 157
E+ + +EEL +LL A E ++ I D+L E++Q +Q+ +++
Sbjct: 299 KSNELTRAVEELH-KLLKEAGEANKAIQDHLLEVEQ---------------SKDQMEKEM 342
Query: 158 TPYAQRMERVLRENADSLQASLRPHADELKAKIDQNVEELKGRLTPYADEFKVKIDQTVE 217
R+E+ L ENA+ L ++ + L EE ++P A KI +
Sbjct: 343 LEKIGRLEKEL-ENANDLLSATKRKGAILS-------EEELAAMSPTAAAV-AKIVKPGM 393
Query: 218 ELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELKARISASAEELRQRLAPLAEDVRGN 277
+L Y + + L +LE ++ K +E+ + A A L+++
Sbjct: 394 KLTELYNAYVETQDQLLLEKLENK--RINKYLDEIVKEVEAKAPILKRQ----------- 440
Query: 278 LRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVE 337
R E QK++A L L+Q ++E +R E + ++ V + + R ++ D+
Sbjct: 441 -REEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEI--QVKDLS 497
Query: 338 GHLSFLEKDLRDKVNSFFSTFKEKESQDKTLSLPELEQ---QQEQQQEQQQEQVQMLAPL 394
+ L +L + + +E S D + S + Q +E QQ+ ++L L
Sbjct: 498 QQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVAL 557
Score = 50.8 bits (120), Expect = 2e-06
Identities = 79/318 (24%), Positives = 138/318 (43%), Gaps = 48/318 (15%)
Query: 89 ERLAKDSEKLKEEIGKELEELR--ARLLPHANEVSQKI---------GDNLRELQQRLEP 137
E L ++ ++L++ + E E+++ A+ + E+ +K LRE ++RLE
Sbjct: 1229 ELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQ 1288
Query: 138 YADQLRTQVSTQAEQLRRQLTPYAQRMERVLRENADSLQASLRPHADELKAKIDQNVEEL 197
Q++ +V +L + P Q L E + LQA K ++++V+
Sbjct: 1289 DLQQMQAKV----RKLELDILPL-QEANAELSEKSGMLQAE--------KKLLEEDVKRW 1335
Query: 198 KGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELKARIS 257
K R + K D EE R+ L+ T+ +++ LT ++ + E+ AR +
Sbjct: 1336 KARNQHLVSQQK---DPDTEEYRKLLSEKEVHTK-----RIQQLTEEIGRLKAEI-ARSN 1386
Query: 258 ASAEELRQRLAPLAEDVRGNLRGNTEGLQKSLAELGGHLDQ------QVEEFRRRVEPYG 311
AS + + L ED+ +R E +QK L + + QV++ RR +
Sbjct: 1387 ASLTNNQNLIQSLKEDLN-KVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQY 1445
Query: 312 ENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLE-KDLRDKVNSFFSTFKEKESQ----DK 366
E + ME Q G H E H+S E ++L++ +N + K ESQ K
Sbjct: 1446 EELKAQQDKVMETSAQSSGDHQ---EQHVSVQEMQELKETLNQAETKSKSLESQVENLQK 1502
Query: 367 TLSLPELEQQQEQQQEQQ 384
TLS E E + Q+Q Q
Sbjct: 1503 TLSEKETEARNLQEQTVQ 1520
Score = 48.1 bits (113), Expect = 1e-05
Identities = 80/362 (22%), Positives = 149/362 (41%), Gaps = 76/362 (20%)
Query: 68 EVNTYAGDLQKKLVPFATEL----------HERLAKDSEKLKEEIGKELEELRARLLPHA 117
E+N +Q KL F + HE+ +SE+ EI K L + RL+
Sbjct: 13 ELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNET 72
Query: 118 NEVS------QKIGDNLRELQQR---LEPYADQ---LRTQVSTQAEQLRRQ--------- 156
E +K+ + L+ L ++ LE D+ +++Q + E+L +
Sbjct: 73 RECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNE 132
Query: 157 --------LTPYAQRMERVLRENADSLQASLRPHADELKA----------KIDQNVEELK 198
LT +R+ L+E +++ + L+ DEL+A +++Q E L
Sbjct: 133 RLSQELEYLTEDVKRLNEKLKE-SNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLH 191
Query: 199 GRLTPYADEFKVKIDQ----------TVEELRRSLAPYAQDTQEKLNHQLEGL---TFQM 245
+ T E K K D+ + EL+ +L ++ +L Q+ GL +
Sbjct: 192 SQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEV-SRLEEQMNGLKTSNEHL 250
Query: 246 KKNAEELKARISASAEELRQRLAPLAEDVRGNLRGNTE--GLQKSLAE----LGGHLDQQ 299
+K+ E+L ++ +E +++ A + E L + + L KS A+ L +
Sbjct: 251 QKHVEDLLTKL----KEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRA 306
Query: 300 VEEFRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDKVNSFFSTFK 359
VEE + ++ GE NKA+ + ++ Q ++ + LEK+L + N S K
Sbjct: 307 VEELHKLLKEAGE-ANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKEL-ENANDLLSATK 364
Query: 360 EK 361
K
Sbjct: 365 RK 366
Score = 39.7 bits (91), Expect = 0.005
Identities = 74/316 (23%), Positives = 127/316 (40%), Gaps = 47/316 (14%)
Query: 39 SNNAKEAVEHLQKS-ELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSEK 97
SN AVE L K + + N QD L EV ++K+++ L + L ++
Sbjct: 300 SNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDL 359
Query: 98 LKEEIGKEL---EELRARLLPHANEVSQ--KIGDNLREL-----------------QQRL 135
L K EE A + P A V++ K G L EL +R+
Sbjct: 360 LSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRI 419
Query: 136 EPYADQLRTQVSTQAEQLRRQLTPYAQRMERVLRENADSLQASLRPHADELKAKIDQNVE 195
Y D++ +V +A L+RQ Y E A AS L K++Q ++
Sbjct: 420 NKYLDEIVKEVEAKAPILKRQREEY---------ERAQKAVAS-------LSVKLEQAMK 463
Query: 196 ELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQL----EGLTFQMKKNAEE 251
E++ RL D+ K +E R + +D +++ L E + ++ E
Sbjct: 464 EIQ-RLQEDTDKAN-KQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEV 521
Query: 252 LKARISASAEELRQRLAPLAEDVRGNLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYG 311
A IS+S+E + Q L L+ + L +L ELG +++ +E
Sbjct: 522 SSADISSSSEVISQHLVSYRN--IEELQQQNQRLLVALRELGETREREEQETTSSKITEL 579
Query: 312 ENFNKALVQQMEQLRQ 327
+ ++ + ++EQLR+
Sbjct: 580 QLKLESALTELEQLRK 595
Score = 37.0 bits (84), Expect = 0.031
Identities = 80/382 (20%), Positives = 159/382 (41%), Gaps = 75/382 (19%)
Query: 54 LTQQLNALFQD------KLGEVNTYAGDLQKKLVPFATE------LHERLAKDSE----- 96
L+Q+L L +D KL E NT G+LQ KL +RL ++ E
Sbjct: 134 LSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLHSQ 193
Query: 97 ----------------KLKEEIGKELEELRARLLPHANEVS--QKIGDNLRELQQRLEPY 138
L E G E+ EL+ L EVS ++ + L+ + L+ +
Sbjct: 194 NTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKH 253
Query: 139 ADQLRT-------QVSTQAEQLRRQLTPYAQRMERVLRENADSLQASLRPHADELKAKID 191
+ L T Q ++ E+ +L + ++ + + AD +A ++EL ++
Sbjct: 254 VEDLLTKLKEAKEQQASMEEKFHNELNAHI-KLSNLYKSAADDSEAK----SNELTRAVE 308
Query: 192 QNVEELK--GRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNA 249
+ + LK G + ++++Q+ +++ + + +++L + + L+ +K A
Sbjct: 309 ELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGA 368
Query: 250 ---EELKARISASAEELRQRLAP---LAEDVRGNLRGNTEGLQKSL--AELGGHLDQQVE 301
EE A +S +A + + + P L E + + L + L + +LD+ V+
Sbjct: 369 ILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVK 428
Query: 302 E-------FRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDKVNSF 354
E +R+ E Y E KA+ +L Q + + L++D DK N
Sbjct: 429 EVEAKAPILKRQREEY-ERAQKAVASLSVKLEQAM--------KEIQRLQED-TDKANK- 477
Query: 355 FSTFKEKESQDKTLSLPELEQQ 376
S+ E++++ + + +L QQ
Sbjct: 478 QSSVLERDNRRMEIQVKDLSQQ 499
Score = 35.8 bits (81), Expect = 0.069
Identities = 46/190 (24%), Positives = 84/190 (44%), Gaps = 15/190 (7%)
Query: 106 LEELRARLLPHA--NEVSQKIGDNLRELQQRLEPYADQLRTQVSTQAEQLRRQLTPYAQR 163
LE LP + N++ + + D E+ L+ ++ + + Q ++ ++L+ +R
Sbjct: 9 LERTELNKLPKSVQNKLEKFLADQQSEIDG-LKGRHEKFKVESEQQYFEIEKRLSHSQER 67
Query: 164 MERVLRENADSLQASLRPHADELKAKIDQNVEELKGRLTPYADEFKVKIDQTVEELRRSL 223
+ RE SL+ L ++LKA ++N E A + + I + L
Sbjct: 68 LVNETRE-CQSLRLELEKLNNQLKALTEKNKE------LEIAQDRNIAIQSQFTRTKEEL 120
Query: 224 APYAQD---TQEKLNHQLEGLTFQMKKNAEELKARISASAEELRQRLAPL-AEDVRGNLR 279
+D T E+L+ +LE LT +K+ E+LK + + EL+ +L L A DV R
Sbjct: 121 EAEKRDLIRTNERLSQELEYLTEDVKRLNEKLK-ESNTTKGELQLKLDELQASDVSVKYR 179
Query: 280 GNTEGLQKSL 289
+K L
Sbjct: 180 EKRLEQEKEL 189
Score = 29.6 bits (65), Expect = 5.0
Identities = 76/395 (19%), Positives = 153/395 (38%), Gaps = 55/395 (13%)
Query: 43 KEAVEHLQKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSEKLKEEI 102
+E E QK+ L+ + + E+ D K A + L +D+ +++ ++
Sbjct: 441 REEYERAQKA--VASLSVKLEQAMKEIQRLQEDTDK-----ANKQSSVLERDNRRMEIQV 493
Query: 103 GK----------ELEELRARLLPHANEVSQK-IGDNLRELQQRLEPYADQLRTQVSTQAE 151
ELEE R + EVS I + + Q L Y + ++ Q +
Sbjct: 494 KDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNI--EELQQQNQ 551
Query: 152 QLRRQLTPYAQRMERVLRENADS----LQASLRPHADELKA--KIDQNVEELKGRLTPYA 205
+L L + ER +E S LQ L EL+ K Q+ +L +
Sbjct: 552 RLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQR 611
Query: 206 DEFKVKIDQT-----------VEELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELKA 254
D +++ + QT ++++ + P T + ++ + ++ E ++A
Sbjct: 612 DMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAP---VPVIESTEAIEA 668
Query: 255 RISASAEELRQRLAPLAEDVRGNLRGNTEGLQK------SLAELGGHLDQQVEEFRRRVE 308
+ A+ ++L++ ++ N + E L+K L + Q++ +R E
Sbjct: 669 K--AALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYE 726
Query: 309 PYGENFN--KALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDK-----VNSFFSTFKEK 361
+N + + + + QKL E ++ + +DLR V + +K
Sbjct: 727 MLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKK 786
Query: 362 ESQDKTLSLPELEQQQEQQQEQQQEQVQMLAPLES 396
E + LS L QQ+E +Q+ Q +L L++
Sbjct: 787 EKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQT 821
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 59.7 bits (143), Expect = 4e-09
Identities = 88/363 (24%), Positives = 161/363 (44%), Gaps = 46/363 (12%)
Query: 38 LSNNAKEAVEHLQKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFAT---ELHERLAKD 94
L N+ ++ E L+K + +LNAL ++ + LQKKL EL E L +
Sbjct: 1069 LENDKQQLDERLKKKDF--ELNAL-NARIEDEQALGSQLQKKLKELQARIEELEEELEAE 1125
Query: 95 S------EKLKEEIGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVST 148
EKL+ ++ +ELEE+ RL S +I E+ ++ E ++R +
Sbjct: 1126 RTARAKVEKLRSDLSRELEEISERLEEAGGATSVQI-----EMNKKREAEFQKMRRDL-- 1178
Query: 149 QAEQLRRQLTPYAQRMERVLRENADSLQASLRPHADELKAKIDQNVEELKGRLTPYADEF 208
+ L+ + T A R +++ADS+ EL +ID N++ +K +L EF
Sbjct: 1179 EEATLQHEATAAALR-----KKHADSVA--------ELGEQID-NLQRVKQKLEKEKSEF 1224
Query: 209 KVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELKARISASAEELRQRLA 268
K+++D + + + A+ EK+ LE + + AEE + S +L + A
Sbjct: 1225 KLELDDVTSNMEQIIK--AKANLEKMCRTLEDQMNEHRSKAEETQ----RSVNDLTSQRA 1278
Query: 269 PLAEDVRGNLRGNTEGLQKSLAEL-GGHL--DQQVEEFRRRVEPYGENFNKALVQQMEQL 325
L + G L + + +++L G L QQ+E+ +R++E + N AL ++
Sbjct: 1279 KLQTE-NGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKN-ALAHALQSA 1336
Query: 326 RQ--KLGPHAGDVEGHLSFLEKDLRDKVNSFFSTFKEKESQDKTLSLPELEQQQEQQQEQ 383
R L + E + + K NS + ++ K D ELE+ +++ ++
Sbjct: 1337 RHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQR 1396
Query: 384 QQE 386
QE
Sbjct: 1397 LQE 1399
Score = 43.1 bits (100), Expect = 4e-04
Identities = 70/299 (23%), Positives = 129/299 (43%), Gaps = 51/299 (17%)
Query: 51 KSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHER------LAKDSEKLKEEIG- 103
K ++ LN + + +L N A + QK++ + L + + ++ LKE I
Sbjct: 1615 KKKMEGDLNEM-EIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAI 1673
Query: 104 ---------KELEELRARLLPHANEVSQKIGDN-LRELQQRLEPYADQLRTQVSTQAEQL 153
ELEELRA + E S+K+ + L E +R++ Q T + Q +++
Sbjct: 1674 VERRNNLLQAELEELRA--VVEQTERSRKLAEQELIETSERVQLLHSQ-NTSLINQKKKM 1730
Query: 154 RRQLTPYAQRMERVLRENADSLQASLRPHADELKAKIDQNVEELKGR--LTPYADEFKVK 211
L+ +E ++E ++ + + + D EELK + + + K
Sbjct: 1731 DADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMM-----AEELKKEQDTSAHLERMKKN 1785
Query: 212 IDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELKARISASAEELRQRLAPLA 271
++QT+++L+ L D E++ L+G KK ++L+AR+ EL A
Sbjct: 1786 MEQTIKDLQHRL-----DEAEQI--ALKG----GKKQLQKLEARVRELENELEAEQKRNA 1834
Query: 272 EDVRG---------NLRGNTEGLQKSLAELGGHLDQ---QVEEFRRRVEPYGENFNKAL 318
E V+G L TE +K+L L +D+ +V+ ++R+ E E N L
Sbjct: 1835 ESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNL 1893
Score = 34.3 bits (77), Expect = 0.20
Identities = 48/214 (22%), Positives = 97/214 (45%), Gaps = 25/214 (11%)
Query: 36 SQLSNNAKEAVEHLQKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELH-ERLAKD 94
SQL +EAV+ + +E + + + A +L+K+ T H ER+ K+
Sbjct: 1735 SQLQTEVEEAVQECRNAEEKAK------KAITDAAMMAEELKKEQ---DTSAHLERMKKN 1785
Query: 95 SEKLKEEIGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVST----QA 150
E+ +++ L+E L + QK+ +REL+ LE A+Q R S ++
Sbjct: 1786 MEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELE--AEQKRNAESVKGMRKS 1843
Query: 151 EQLRRQLTPYAQRMERV----LRENADSLQASLRPH---ADELKAKIDQNVEELKGRLTP 203
E+ ++LT Y +R L++ D LQ ++ + A+E + + + N+ + + ++
Sbjct: 1844 ERRIKELT-YQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFR-KVQH 1901
Query: 204 YADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQ 237
DE + + D ++ + A + LN +
Sbjct: 1902 ELDEAEERADIAESQVNKLRAKSRDIGTKGLNEE 1935
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 59.3 bits (142), Expect = 6e-09
Identities = 91/407 (22%), Positives = 181/407 (44%), Gaps = 57/407 (14%)
Query: 19 RAEVSADQVATVMWDYFSQLSNNAKEAVEHLQKSELTQQLNALFQDKLGEVNTYAGDLQK 78
+ ++ +Q T + D QLS E ++ ++SE ++ AL ++ L DLQ
Sbjct: 688 QVKMEREQHQTEIRDLQDQLSEMHDE-LDSAKRSE-DREKGALIEELLQAKQ----DLQD 741
Query: 79 KLVPFATELHERLAKDSEK--------LKEEIGKELEELRARLLPHANEVSQKIGDNLRE 130
L+ A E E L + E+ LKEE+ +E+ +L + Q + +++ E
Sbjct: 742 LLI--AKEEQEDLLRKRERELTALKGALKEEVSSHDQEMD-KLKEQYDAELQALRESVEE 798
Query: 131 LQQRLEPYADQLRTQVSTQAEQLRRQLTPYAQRMERVLRENADSLQASLRPHADELK--- 187
+ +E A + T QA R ++L+E + LQ ++EL+
Sbjct: 799 ATKNVEVLASRSNTSEQDQAGTEMRV---------KLLQEENEKLQG----RSEELERRV 845
Query: 188 AKIDQNVEELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEK------LNHQLEGL 241
A++ + +E+LKG + K K + + +L +L ++ +E L ++LE
Sbjct: 846 AQLQRQIEDLKGDEAKAKETLK-KYEGEIRQLEEALVHARKEEKEAVSARRALENELEAA 904
Query: 242 -------TFQMKKNAEELKARISASAEELRQRLAPLAEDVRGNLRGNTEGLQKSLAELGG 294
T + K+ +E+LK S E+LR RL E+ R +L E LQK +A++
Sbjct: 905 QGNLSQTTQEQKQLSEKLKEE-SEQKEQLR-RLKNEMENERWHLGKTIEKLQKEMADIVE 962
Query: 295 HLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKL------GPHAGDVEGHLSFLEKDLR 348
E + +++ Y E + L + QL++K A ++ + +E++LR
Sbjct: 963 ASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELR 1022
Query: 349 DKVNSFFSTFKEKESQDKTLSLPELEQQQEQQQEQQQEQVQMLAPLE 395
D + +++ ++TL +LE + E + + ++ +++ +E
Sbjct: 1023 DYQRAQDEALTKRQLLEQTLK--DLEYELEAKSHLKDDRSRLVKQME 1067
Score = 50.4 bits (119), Expect = 3e-06
Identities = 83/341 (24%), Positives = 136/341 (39%), Gaps = 63/341 (18%)
Query: 95 SEKLKEEIGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVSTQAEQLR 154
SEKLKEE ++ E+LR RL +G + +LQ+ + + RT +L+
Sbjct: 919 SEKLKEE-SEQKEQLR-RLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTL----ELQ 972
Query: 155 RQLTPYAQRMERVLRENADSL-QASLRPHADELKA-KIDQNVEELKGRLTPYA---DEFK 209
QL Y ++ R L E L + +L L A K+ + ++ L Y DE
Sbjct: 973 NQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEAL 1032
Query: 210 VK---IDQTVEELRRSLAP--YAQDTQEKLNHQLEGLTFQMKKNAEE-------LKARIS 257
K ++QT+++L L + +D + +L Q+E Q++ EE L RIS
Sbjct: 1033 TKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERIS 1092
Query: 258 ASAEELRQRLAPLAED---------------------------VRGNLRGNTEGL----Q 286
S E++ Q L ++ + G+ R + EGL +
Sbjct: 1093 RSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQME 1152
Query: 287 KSLAELGGHLDQQVEEFRRRVEPYGENFN---KALVQQMEQLRQKLGPHAGDVEGHLSFL 343
+AEL L+ + E R ++ K LV Q++ L D + LS
Sbjct: 1153 ARIAELEDRLESE-ERDRANLQLSNRRLERKVKELVMQVDDEHLSL----TDQKDQLSLR 1207
Query: 344 EKDLRDKVNSFFSTFKEKESQDKTLSLPELEQQQEQQQEQQ 384
K ++ +V ES K L ELE+Q + + Q
Sbjct: 1208 LKAMKRQVEEAEEEIDRLESSKKKLQ-RELEEQMDMNEHLQ 1247
Score = 37.7 bits (86), Expect = 0.018
Identities = 68/365 (18%), Positives = 155/365 (42%), Gaps = 36/365 (9%)
Query: 55 TQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSEKLKEEIGKELEELRARLL 114
T + Q++ + +G + + F + + + D K ++E+ ++ E A+ +
Sbjct: 499 TATATLMLQNRATATSPDSGAKKISVKTFPSASNTQATPDLLKGQQELTQQTNEETAKQI 558
Query: 115 PHANEVSQKIGDNLRELQQRLEPYADQLRTQVSTQA--EQLRRQLTPYAQRMERVLRENA 172
+ N + + DN ++++ ++++T S A Q Q ++ +L + +
Sbjct: 559 LY-NYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKS 617
Query: 173 D-SLQASLRPHADELKAKIDQNVEELKGRLTPYADEFKVKIDQTVE-------------- 217
+++ + +L+ K QN++E + R+ +E + + ++ VE
Sbjct: 618 KLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEG 677
Query: 218 ELRRSLAPYAQDTQEKLNHQLE--GLTFQMKKNAEEL-KARISASAEE--LRQRLAPLAE 272
ELR++L Q E+ HQ E L Q+ + +EL A+ S E+ L + L +
Sbjct: 678 ELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQ 737
Query: 273 DVRGNLRGNTE------GLQKSLAELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLR 326
D++ L E ++ L L G L ++V + ++ E ++ +++ LR
Sbjct: 738 DLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYD----AELQALR 793
Query: 327 QKLGPHAGDVEGHLSFLEKDLRDKVNSFFSTFKEKESQDKTLSLPELEQQQEQQQEQQQE 386
+ + +VE S +D+ + + K Q++ L ++ E++ Q Q
Sbjct: 794 ESVEEATKNVEVLASRSNTSEQDQAG---TEMRVKLLQEENEKLQGRSEELERRVAQLQR 850
Query: 387 QVQML 391
Q++ L
Sbjct: 851 QIEDL 855
>gi|134304846 Rb1-inducible coiled coil protein 1 isoform 2 [Homo
sapiens]
Length = 1591
Score = 57.4 bits (137), Expect = 2e-08
Identities = 82/401 (20%), Positives = 173/401 (43%), Gaps = 53/401 (13%)
Query: 30 VMWDY---FSQLSNNAKEAVEHLQKS--ELTQQLNALFQD---KLGEVNTYAGDLQKKLV 81
VM D+ +L ++ + +Q+S E+ Q+ Q+ K+ +++ L+ +L
Sbjct: 1006 VMTDHRVSLEELKKENQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELA 1065
Query: 82 PFATE-------LHERLAKDSEKLKEEIGKELEELRARLLPHANEVSQKIGDNLRELQQR 134
E L E A+ E LK + +E E LR + ++++QKI DN Q
Sbjct: 1066 LKEAETDEIKILLEESRAQQKETLKSLLEQETENLRTEI----SKLNQKIQDNNENYQVG 1121
Query: 135 LEPYADQLRTQVSTQAEQLRRQLTPYAQRMERVLR----------ENADSLQASLRPHAD 184
L +LRT ++ + +Q +L + +L+ A ++ +L+
Sbjct: 1122 LA----ELRTLMTIEKDQCISELISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQII 1177
Query: 185 ELKAKIDQNVEELKG----RLTPYADEFKVKIDQTVEELRRSLAPYAQDTQE---KLNHQ 237
EL++K+D + L+ ++T ++++ I ++ ++ ++ QD ++ KLN +
Sbjct: 1178 ELQSKLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCE 1237
Query: 238 ----LEGLTFQMKKNAEELKARISASAEELRQRLA--PLAEDVRGNLRGNTEGLQKSLAE 291
++ + K E ++ + + L ++A P + RG+ LQ+ L E
Sbjct: 1238 KDEAIQTALKEFKLEREVVEKELLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQE 1297
Query: 292 LGGHLDQQVEEFRRRVEPYGENFNKALV-QQMEQLRQKLGPHAGDVEGHLSFLEKDLRDK 350
+Q+EE +R +N +L+ +Q L E ++ DL DK
Sbjct: 1298 EKAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENIIN----DLSDK 1353
Query: 351 VNSFFSTFKEKESQDKTLSLPELEQQQEQQQEQQQEQVQML 391
+ S +++ +D SL E + +++++ +E+V L
Sbjct: 1354 LKSTMQ--QQERDKDLIESLSEDRARLLEEKKKLEEEVSKL 1392
Score = 55.5 bits (132), Expect = 8e-08
Identities = 70/354 (19%), Positives = 152/354 (42%), Gaps = 38/354 (10%)
Query: 48 HLQKSELTQQLNAL--FQDKLGEVNTYAGDLQKK---LVPFATELHERLAKDSEKLKEEI 102
HL++ E T Q+ + F+ + + +L+K+ ++ E H + ++ EK +E+
Sbjct: 987 HLKELEDTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESHAEIIQEKEKQLQEL 1046
Query: 103 GKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVSTQAEQLRRQLTPYAQ 162
++ +L E++ K + E++ LE Q + + + EQ L
Sbjct: 1047 KLKVSDLSDTRCKLEVELALKEAET-DEIKILLEESRAQQKETLKSLLEQETENLRTEIS 1105
Query: 163 RMERVLRENADSLQASLRPHADELKAKIDQNVEELKGRLTPYADEFKVKIDQTVE----- 217
++ + +++N ++ Q L + + DQ + EL R ++ K ++++
Sbjct: 1106 KLNQKIQDNNENYQVGLAELRTLMTIEKDQCISELISRHEEESNILKAELNKVTSLHNQA 1165
Query: 218 -ELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELKARISASAEEL---RQRLAPLAED 273
E+ ++L + Q KL+ +L L Q + + + + A + L RQ+L E
Sbjct: 1166 FEIEKNLKEQIIELQSKLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQ 1225
Query: 274 VRGNLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLG--P 331
R L +QK E + ++EF+ E K L+++++ L ++ P
Sbjct: 1226 DREQL------IQKLNCEKDEAIQTALKEFKLEREVV----EKELLEKVKHLENQIAKSP 1275
Query: 332 HAGDVEGHLSFLEKDLRDKVNSFFSTFKEKESQDKTLSLPELEQQQEQQQEQQQ 385
G S L +L++K+ ++K L +LE+Q++++ E+ Q
Sbjct: 1276 AIDSTRGDSSSLVAELQEKLQ-----------EEKAKFLEQLEEQEKRKNEEMQ 1318
>gi|134304842 Rb1-inducible coiled coil protein 1 isoform 1 [Homo
sapiens]
Length = 1594
Score = 57.4 bits (137), Expect = 2e-08
Identities = 82/401 (20%), Positives = 173/401 (43%), Gaps = 53/401 (13%)
Query: 30 VMWDY---FSQLSNNAKEAVEHLQKS--ELTQQLNALFQD---KLGEVNTYAGDLQKKLV 81
VM D+ +L ++ + +Q+S E+ Q+ Q+ K+ +++ L+ +L
Sbjct: 1006 VMTDHRVSLEELKKENQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELA 1065
Query: 82 PFATE-------LHERLAKDSEKLKEEIGKELEELRARLLPHANEVSQKIGDNLRELQQR 134
E L E A+ E LK + +E E LR + ++++QKI DN Q
Sbjct: 1066 LKEAETDEIKILLEESRAQQKETLKSLLEQETENLRTEI----SKLNQKIQDNNENYQVG 1121
Query: 135 LEPYADQLRTQVSTQAEQLRRQLTPYAQRMERVLR----------ENADSLQASLRPHAD 184
L +LRT ++ + +Q +L + +L+ A ++ +L+
Sbjct: 1122 LA----ELRTLMTIEKDQCISELISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQII 1177
Query: 185 ELKAKIDQNVEELKG----RLTPYADEFKVKIDQTVEELRRSLAPYAQDTQE---KLNHQ 237
EL++K+D + L+ ++T ++++ I ++ ++ ++ QD ++ KLN +
Sbjct: 1178 ELQSKLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCE 1237
Query: 238 ----LEGLTFQMKKNAEELKARISASAEELRQRLA--PLAEDVRGNLRGNTEGLQKSLAE 291
++ + K E ++ + + L ++A P + RG+ LQ+ L E
Sbjct: 1238 KDEAIQTALKEFKLEREVVEKELLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQE 1297
Query: 292 LGGHLDQQVEEFRRRVEPYGENFNKALV-QQMEQLRQKLGPHAGDVEGHLSFLEKDLRDK 350
+Q+EE +R +N +L+ +Q L E ++ DL DK
Sbjct: 1298 EKAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENIIN----DLSDK 1353
Query: 351 VNSFFSTFKEKESQDKTLSLPELEQQQEQQQEQQQEQVQML 391
+ S +++ +D SL E + +++++ +E+V L
Sbjct: 1354 LKSTMQ--QQERDKDLIESLSEDRARLLEEKKKLEEEVSKL 1392
Score = 55.5 bits (132), Expect = 8e-08
Identities = 70/354 (19%), Positives = 152/354 (42%), Gaps = 38/354 (10%)
Query: 48 HLQKSELTQQLNAL--FQDKLGEVNTYAGDLQKK---LVPFATELHERLAKDSEKLKEEI 102
HL++ E T Q+ + F+ + + +L+K+ ++ E H + ++ EK +E+
Sbjct: 987 HLKELEDTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESHAEIIQEKEKQLQEL 1046
Query: 103 GKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVSTQAEQLRRQLTPYAQ 162
++ +L E++ K + E++ LE Q + + + EQ L
Sbjct: 1047 KLKVSDLSDTRCKLEVELALKEAET-DEIKILLEESRAQQKETLKSLLEQETENLRTEIS 1105
Query: 163 RMERVLRENADSLQASLRPHADELKAKIDQNVEELKGRLTPYADEFKVKIDQTVE----- 217
++ + +++N ++ Q L + + DQ + EL R ++ K ++++
Sbjct: 1106 KLNQKIQDNNENYQVGLAELRTLMTIEKDQCISELISRHEEESNILKAELNKVTSLHNQA 1165
Query: 218 -ELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELKARISASAEEL---RQRLAPLAED 273
E+ ++L + Q KL+ +L L Q + + + + A + L RQ+L E
Sbjct: 1166 FEIEKNLKEQIIELQSKLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQ 1225
Query: 274 VRGNLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLG--P 331
R L +QK E + ++EF+ E K L+++++ L ++ P
Sbjct: 1226 DREQL------IQKLNCEKDEAIQTALKEFKLEREVV----EKELLEKVKHLENQIAKSP 1275
Query: 332 HAGDVEGHLSFLEKDLRDKVNSFFSTFKEKESQDKTLSLPELEQQQEQQQEQQQ 385
G S L +L++K+ ++K L +LE+Q++++ E+ Q
Sbjct: 1276 AIDSTRGDSSSLVAELQEKLQ-----------EEKAKFLEQLEEQEKRKNEEMQ 1318
>gi|64085252 hypothetical protein LOC145508 [Homo sapiens]
Length = 1094
Score = 57.4 bits (137), Expect = 2e-08
Identities = 90/408 (22%), Positives = 168/408 (41%), Gaps = 58/408 (14%)
Query: 25 DQVATVMWDYFSQLSNNAKEAVEHLQKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFA 84
D++ T ++ Q+ N KE + L K L ++ ++KL ++ ++ DL+ ++
Sbjct: 526 DELKTQLYAALQQIENLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQADLELEVKNSL 585
Query: 85 TELHERLAKDSEKLKEEIGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRT 144
+H RL + +K + +I +++ +A L E+ + + +L + E D
Sbjct: 586 DTIH-RLESELKK-QSKIQSQMKVEKAHLEEEIAELKKSQAQDKAKLLEMQESIKD---- 639
Query: 145 QVSTQAEQLRRQLTPYAQRMERVLRENAD-SLQASLRPH-----ADELKAKIDQNVEELK 198
+S L +L + + VL++ +D + QA R +LK + D + ELK
Sbjct: 640 -LSAIRADLANKLAEEERAKKAVLKDLSDLTAQAKSRDEETATIITQLKLERDVHQRELK 698
Query: 199 GRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNH--QLEGLTFQMKKNA------- 249
LT K K +Q ++EL + + ++ E NH L+ + + K A
Sbjct: 699 D-LTSSLQSVKTKHEQNIQELMKH---FKKEKSEAENHIRTLKAESLEEKNMAKIHRGQL 754
Query: 250 EELKARISASAEELRQRLAPLAEDVRGNLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEP 309
E+LK++ EEL Q E+ L+ + L+ L E H+ + E RR E
Sbjct: 755 EKLKSQCDRLTEELTQN-----ENENKKLKLKYQCLKDQLEEREKHISIEEEHLRRMEEA 809
Query: 310 YGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDKVNSFFS------------- 356
+ ++ L + EQ LG +++ KD +K+ F S
Sbjct: 810 RLQLKDQLLCLETEQ-ESILGVIGKEIDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLA 868
Query: 357 -----------TFKEKESQDKTL--SLPELEQQQEQQQEQQQEQVQML 391
KE+E+++K L L QQ E ++ ++Q L
Sbjct: 869 ESKTKLQWLCEELKERENREKNLRHQLMLCRQQLRNLTENKESELQCL 916
Score = 46.2 bits (108), Expect = 5e-05
Identities = 69/340 (20%), Positives = 141/340 (41%), Gaps = 36/340 (10%)
Query: 37 QLSNNAKEAVEHLQKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELH--ERLAKD 94
Q+ + KE H E ++ L ++ E+ +A D K+ + +EL E L ++
Sbjct: 418 QMLDRLKEIQNHFDTCEAERKHADL---QISELTRHAEDATKQAERYLSELQQSEALKEE 474
Query: 95 SEKLKEEIGKELEE------LRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVST 148
+EK +E++ + +E L+ + L A E + D L ++ D+L+TQ+
Sbjct: 475 AEKRREDLKLKAQESIRQWKLKHKKLERALEKQSETVDELTGKNNQILKEKDELKTQLYA 534
Query: 149 ---QAEQLRRQLTPYAQR---MERVLRENADSLQASLRPHADELKAKIDQNVE------- 195
Q E LR++L + E L + L+ ++ H +L+ ++ +++
Sbjct: 535 ALQQIENLRKELNDVLTKRALQEEELHSKEEKLR-DIKSHQADLELEVKNSLDTIHRLES 593
Query: 196 ELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELKAR 255
ELK + + + KV+ EE+ AQD + L Q + K+ ++A
Sbjct: 594 ELK-KQSKIQSQMKVEKAHLEEEIAELKKSQAQDKAKLLEMQ------ESIKDLSAIRAD 646
Query: 256 ISAS-AEELRQRLAPLAE--DVRGNLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGE 312
++ AEE R + A L + D+ + E + +L D E + +
Sbjct: 647 LANKLAEEERAKKAVLKDLSDLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSSL-Q 705
Query: 313 NFNKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDKVN 352
+ Q +++L + + E H+ L+ + ++ N
Sbjct: 706 SVKTKHEQNIQELMKHFKKEKSEAENHIRTLKAESLEEKN 745
Score = 34.7 bits (78), Expect = 0.15
Identities = 62/314 (19%), Positives = 126/314 (40%), Gaps = 37/314 (11%)
Query: 96 EKLKEEIGKELEELRA-RLLPH------------ANEVSQKIGDNLRELQQRLEPYADQL 142
E LKE + + +++LR+ RLL + A+++ G L P L
Sbjct: 77 EHLKESLEQSIDQLRSQRLLRNSGGRSISVTSLSASDLDGGTGSELHHF-----PPTSPL 131
Query: 143 RTQVSTQAEQLRRQLTPYAQRMERVLRENADSLQASLRPHADELKAKIDQNVEELKGRLT 202
+ Q + R T E SLR + E D EL R
Sbjct: 132 KDYGDPQGIKRMRSRTGVRFVQETDDMTQLHGFHQSLRDLSSEQIRLGDDFNRELSRRSR 191
Query: 203 PYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELKAR------I 256
A E K +++ E+L A + +++ +L+ L +M+ E ++ R +
Sbjct: 192 SDA-ETKRALEELTEKLNE--AQKQEVVSDRVERRLQELEREMRTERELVERRQDQLGLM 248
Query: 257 SASAEELRQRLAPLAEDVRGNLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENFNK 316
S +E ++ A++ G ++ + +L +Q E RR+ E +
Sbjct: 249 SLQLQEALKKQEAKADEHEGAIKNKLRQTETEKNQL-----EQELELSRRLLNQSEGSRE 303
Query: 317 ALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDKVNSFFSTFKEKESQDKTLSLPELEQQ 376
L+ Q+E+LR +L GD +G L+ + +++ S +++++ +D ++
Sbjct: 304 TLLHQVEELRTQLTKAEGDRKG----LQHQV-SQISKQQSNYQDEQGEDWRFRRGVEREK 358
Query: 377 QEQQQEQQQEQVQM 390
Q+ +++ +VQ+
Sbjct: 359 QDLEKQMSDLRVQL 372
>gi|46592991 GRIP1 associated protein 1 isoform 1 [Homo sapiens]
Length = 841
Score = 57.0 bits (136), Expect = 3e-08
Identities = 93/413 (22%), Positives = 174/413 (42%), Gaps = 73/413 (17%)
Query: 30 VMWDYFSQLSNNAKEAVEHLQK-----SELTQQLNALFQDKLGEVNTYAGDLQKKLVPFA 84
++W+ L ++ + LQ+ SE ++ F E T D + K+
Sbjct: 205 LLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKI---- 260
Query: 85 TELHERLAKD-------SEKLKEEI---GKELEELR----ARLLPHA-------NEVSQK 123
EL +R D ++KL++E+ + L ELR L HA ++VS +
Sbjct: 261 EELQQRKEADHKAQLARTQKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQ 320
Query: 124 IGDNLRELQQRLEPY---------ADQLRTQVSTQAEQLRRQLTPYAQRMERVLRENADS 174
D +++ L +Q++T + + LR Q T A +++ E D
Sbjct: 321 SADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYED- 379
Query: 175 LQASLRPHADELKAKIDQNVEELKGRLTPYADEF---KVKIDQTVEELRRS-------LA 224
L D+L +++ +++ RL E K ++ Q ++E R+S L
Sbjct: 380 ----LMGQKDDLNSQLQESLRA-NSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLD 434
Query: 225 PYAQDT-QEKLNH--QLEGLTFQMKKNAEELKARISASAEELRQRLAPLAEDVRGNLRGN 281
A +T QEK H +L + + +K ++AR EL + E++RG +R
Sbjct: 435 ELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREE 494
Query: 282 T------EGLQKSLAELGGH---LDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLGPH 332
E LQ+++ EL +D F RR++ E+ + +Q E L+Q H
Sbjct: 495 KARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEESLQQQQQEQEEALKQCREQH 554
Query: 333 AGDVEGHLSFLEKDLRDKVNSFFSTFKEKESQDKTLSLPELEQQQEQQQEQQQ 385
A +++G E++L+D + +E++ KT+S L+Q+ + + Q+
Sbjct: 555 AAELKGK----EEELQDVRDQLEQAQEERDCHLKTIS--SLKQEVKDTVDGQR 601
Score = 51.6 bits (122), Expect = 1e-06
Identities = 92/387 (23%), Positives = 167/387 (43%), Gaps = 70/387 (18%)
Query: 43 KEAVEHLQKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHE------RLAKDSE 96
K +E +K L +QL L K E + LQ++L + +L + RL + E
Sbjct: 195 KWEMEKEEKRLLWEQLQGLESSKQAETSR----LQEELAKLSEKLKKKQESFCRLQTEKE 250
Query: 97 KLKEEIGKELEELRARL-LPHANEVS--QKIGDNLRELQQRLEPYADQLRTQVSTQAEQL 153
L + ++EEL+ R H +++ QK+ L Q L DQ + + A L
Sbjct: 251 TLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAELRDQRQGERLEHAAAL 310
Query: 154 RR-------QLTPYAQRMERVLRENADSLQASLRPHADELKAKIDQNVEELKGRLTPYAD 206
R Q +++E +L EN ++L+ SL ++++ Q + L+ + T A
Sbjct: 311 RALQDQVSIQSADAQEQVEGLLAEN-NALRTSLAA-LEQIQTAKTQELNMLREQTTGLAA 368
Query: 207 EF-------------KVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQM---KKNAE 250
E K ++ ++E R+ + + QE + + E LT ++ +K+AE
Sbjct: 369 ELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQE-IGQEKEQLTQELQEARKSAE 427
Query: 251 ELKARISASAEELRQRLAPLAEDVRG-NLRGNTEGL------QKSLAELGGHLDQQVEEF 303
+ KA + A E Q + E++ LR E L ++ L EL +Q EE
Sbjct: 428 KRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERELRELHEDKKRQEEEL 487
Query: 304 RRRVEPYGENFNKALVQQMEQLRQ---KLGPHAGDVEGHLSFLEKDLRDKVNSFFSTFKE 360
R ++ KA +++E L+Q +L ++G + E+ L
Sbjct: 488 RGQIRE-----EKARTRELETLQQTVEELQAQVHSMDGAKGWFERRL------------- 529
Query: 361 KESQDKTLSLPELEQQQEQQQEQQQEQ 387
KE+++ SL + +Q+QE+ +Q +EQ
Sbjct: 530 KEAEE---SLQQQQQEQEEALKQCREQ 553
Score = 41.6 bits (96), Expect = 0.001
Identities = 59/232 (25%), Positives = 93/232 (40%), Gaps = 30/232 (12%)
Query: 50 QKSELTQQL------NALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSEKLKE--- 100
QK +L QL N+ ++L E+ L ++L +R A E E
Sbjct: 383 QKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQ 442
Query: 101 EIGKELEELRARLLPHANEV---SQKIGDNLRELQQRLEPYADQLRTQVSTQAEQLRR-- 155
E + EEL A L H EV + LREL + + ++LR Q+ + + R
Sbjct: 443 EKSQHKEELGAVRLRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELE 502
Query: 156 -------QLTPYAQRM-------ERVLRENADSLQASLRPHADELKAKIDQNVEELKGRL 201
+L M ER L+E +SLQ + + LK +Q+ ELKG+
Sbjct: 503 TLQQTVEELQAQVHSMDGAKGWFERRLKEAEESLQQQQQEQEEALKQCREQHAAELKGKE 562
Query: 202 TPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELK 253
D + +++Q EE L + QE + ++G KK + LK
Sbjct: 563 EELQD-VRDQLEQAQEERDCHLKTISSLKQE-VKDTVDGQRILEKKGSAALK 612
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 56.2 bits (134), Expect = 5e-08
Identities = 86/372 (23%), Positives = 167/372 (44%), Gaps = 46/372 (12%)
Query: 47 EHLQKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHER--LAKDSEKL------ 98
+ LQK + QQ +A ++GE+ L+++ A +L L ++E+
Sbjct: 884 QELQKVQELQQQSAR---EVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAA 940
Query: 99 -KEEIGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVSTQAEQLRRQL 157
K+E+ + EL AR+ E S+++ + LQQ ++ L + + + ++
Sbjct: 941 RKQELELVVSELEARV-GEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKV 999
Query: 158 TPYAQRM----ERVLRENADSLQASLRPHADELKAKIDQNVEELKGRLTPYADEFKVKID 213
T A+ + +L E+ +S + R ++ A+ E + ++ ++ ++K +
Sbjct: 1000 TTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSL-NKLRLKYE 1058
Query: 214 QTVEELRRSLAPYAQDTQE--KLNHQLEGLTFQMKKN-------AEELKARISASAEELR 264
T+ ++ L + QE KL +L+G + ++++ AEEL+A++ EEL+
Sbjct: 1059 ATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQ 1118
Query: 265 QRLAPLAEDVRGNLRGNTEGLQKSLAELGGHLDQQVE--EFRRRVEPYGENFNKALVQQM 322
LA AED G R L KSL E L + E E R E + L +++
Sbjct: 1119 AALA-RAED-EGGARAQ---LLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEEL 1173
Query: 323 EQLRQKLGPHAGDVEGHL--SFLEKDLRDKVNSFFSTFK---EKESQDKTLSLPELEQQQ 377
E LR G++E L + +++LR K + K E+E++ ++ EL Q+
Sbjct: 1174 EALR-------GELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRH 1226
Query: 378 EQQQEQQQEQVQ 389
Q + EQ++
Sbjct: 1227 GQALGELAEQLE 1238
Score = 42.0 bits (97), Expect = 0.001
Identities = 67/319 (21%), Positives = 148/319 (46%), Gaps = 31/319 (9%)
Query: 43 KEAVEHLQKSELTQQLNALFQD------KLGEVNTYAGDLQKKLVPFATE---LHERLAK 93
+EAV+ L+K + Q+ L+++ E+ + + +K+L E L E LA
Sbjct: 1666 EEAVKQLRKMQA--QMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAA 1723
Query: 94 DSEKLKEEIGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVSTQAEQL 153
S++ + + ++ +E+ A + + N I + R+L+ RL ++L + S +E L
Sbjct: 1724 -SDRARRQAQQDRDEM-ADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSN-SELL 1780
Query: 154 RRQLTPYAQRMERVLRENADSLQASLRPHADELKAKIDQNVEELKGRLTPYADEFKVKID 213
+ ++E + E S + S A+ + ++++ ++EL+GRL + +
Sbjct: 1781 NDRYRKLLLQVESLTTEL--SAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHK 1838
Query: 214 QTVEELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELKARISASAEELRQRLAPLAED 273
T+ L LA + +++ ++ L+ ++ + AE+ + EE R+ L +
Sbjct: 1839 MTIAALESKLAQAEEQLEQETRERI--LSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQ 1896
Query: 274 V-RGNLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENFN---KALVQQMEQLRQKL 329
+ +GNLR + L++ L E + + RRR++ E+ +++ +++ LR +L
Sbjct: 1897 LEKGNLR--VKQLKRQLEEAEEEA-SRAQAGRRRLQRELEDVTESAESMNREVTTLRNRL 1953
Query: 330 GPHAGDVEGHLSFLEKDLR 348
G L+F + +R
Sbjct: 1954 R------RGPLTFTTRTVR 1966
Score = 41.2 bits (95), Expect = 0.002
Identities = 73/292 (25%), Positives = 115/292 (39%), Gaps = 60/292 (20%)
Query: 105 ELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVSTQAEQLRRQLTPYAQRM 164
E+ + RA+ L E+ Q+ + ELQ R+ QL + + AEQLR + A+
Sbjct: 877 EVLQARAQELQKVQELQQQSAREVGELQGRVA----QLEEERARLAEQLRAEAELCAEAE 932
Query: 165 ERVLRENADSLQASLRPHADELKAKIDQNVEELKGRLTPYADEFKVKIDQTVEELRRSLA 224
E R + + L EL+A++ + E + T K ++ Q ++EL L
Sbjct: 933 ET--RGRLAARKQELELVVSELEARVGEEEECSRQMQTE-----KKRLQQHIQELEAHLE 985
Query: 225 PYAQDTQEKLNHQLEGLTFQ--MKKNAEELKARISASAEELRQRLAPLAEDVRGNLRGNT 282
+ ++KL QLE +T + MKK E+L L ED L
Sbjct: 986 A-EEGARQKL--QLEKVTTEAKMKKFEEDLL----------------LLEDQNSKLSKER 1026
Query: 283 EGLQKSLAELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSF 342
+ L+ LAE ++ E+ V+ + +LR K D+E L
Sbjct: 1027 KLLEDRLAEFSSQAAEEEEK----------------VKSLNKLRLKYEATIADMEDRLRK 1070
Query: 343 LEKDLRDKVNSFFSTFKEKESQDKTLSLPELEQQQEQQQEQQQEQVQMLAPL 394
EK + E E + L E + QEQ EQQQ ++ A L
Sbjct: 1071 EEKGRQ-----------ELEKLKRRLD-GESSELQEQMVEQQQRAEELRAQL 1110
Score = 40.4 bits (93), Expect = 0.003
Identities = 87/405 (21%), Positives = 163/405 (40%), Gaps = 87/405 (21%)
Query: 50 QKSELTQQLNAL---FQDKLGEVNTYAGDLQKKLVPFATELHERLAKDS-------EKLK 99
Q+ +L ++L AL +D L N +L+ K TEL + L +++ ++L+
Sbjct: 1165 QRRDLGEELEALRGELEDTLDSTNAQQ-ELRSKREQEVTELKKTLEEETRIHEAAVQELR 1223
Query: 100 EEIGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVST------QAEQL 153
+ G+ L EL +L E +++ + + LE +LR ++S+ + EQ
Sbjct: 1224 QRHGQALGELAEQL-----EQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQR 1278
Query: 154 RRQLTPYAQRM-------ERVLRENADSLQAS------LRPHADELKAKIDQNVEELKGR 200
RR+L Q + ER E A+ LQ + + +E ++K + +EL
Sbjct: 1279 RRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSST 1338
Query: 201 LTPYADEFKVKIDQTVEELRRSLAPYAQDTQ---------------EKLNHQLEGLTFQM 245
D ++ ++T +L A + + E+ +L+ Q+
Sbjct: 1339 EAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQL 1398
Query: 246 KK-------------NAEELKARISASAEELRQRLAPLAEDVRGNLRGNTEGLQKSLAEL 292
+ EE + R + AE L QRLA E V RG LQ+ L +
Sbjct: 1399 SEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRR-LQQELDDA 1457
Query: 293 GGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDKVN 352
L+QQ + LV +E+ ++K + + + LR
Sbjct: 1458 TMDLEQQ----------------RQLVSTLEKKQRKFDQLLAEEKAAV------LRAVEE 1495
Query: 353 SFFSTFKEKESQDKTLSLPE-LEQQQEQQQEQQQEQVQMLAPLES 396
+ + +E + + LSL LE++QE ++E +++ + A LE+
Sbjct: 1496 RERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEA 1540
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 56.2 bits (134), Expect = 5e-08
Identities = 86/372 (23%), Positives = 167/372 (44%), Gaps = 46/372 (12%)
Query: 47 EHLQKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHER--LAKDSEKL------ 98
+ LQK + QQ +A ++GE+ L+++ A +L L ++E+
Sbjct: 876 QELQKVQELQQQSAR---EVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAA 932
Query: 99 -KEEIGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVSTQAEQLRRQL 157
K+E+ + EL AR+ E S+++ + LQQ ++ L + + + ++
Sbjct: 933 RKQELELVVSELEARV-GEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKV 991
Query: 158 TPYAQRM----ERVLRENADSLQASLRPHADELKAKIDQNVEELKGRLTPYADEFKVKID 213
T A+ + +L E+ +S + R ++ A+ E + ++ ++ ++K +
Sbjct: 992 TTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSL-NKLRLKYE 1050
Query: 214 QTVEELRRSLAPYAQDTQE--KLNHQLEGLTFQMKKN-------AEELKARISASAEELR 264
T+ ++ L + QE KL +L+G + ++++ AEEL+A++ EEL+
Sbjct: 1051 ATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQ 1110
Query: 265 QRLAPLAEDVRGNLRGNTEGLQKSLAELGGHLDQQVE--EFRRRVEPYGENFNKALVQQM 322
LA AED G R L KSL E L + E E R E + L +++
Sbjct: 1111 AALA-RAED-EGGARAQ---LLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEEL 1165
Query: 323 EQLRQKLGPHAGDVEGHL--SFLEKDLRDKVNSFFSTFK---EKESQDKTLSLPELEQQQ 377
E LR G++E L + +++LR K + K E+E++ ++ EL Q+
Sbjct: 1166 EALR-------GELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRH 1218
Query: 378 EQQQEQQQEQVQ 389
Q + EQ++
Sbjct: 1219 GQALGELAEQLE 1230
Score = 42.0 bits (97), Expect = 0.001
Identities = 67/319 (21%), Positives = 148/319 (46%), Gaps = 31/319 (9%)
Query: 43 KEAVEHLQKSELTQQLNALFQD------KLGEVNTYAGDLQKKLVPFATE---LHERLAK 93
+EAV+ L+K + Q+ L+++ E+ + + +K+L E L E LA
Sbjct: 1658 EEAVKQLRKMQA--QMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAA 1715
Query: 94 DSEKLKEEIGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVSTQAEQL 153
S++ + + ++ +E+ A + + N I + R+L+ RL ++L + S +E L
Sbjct: 1716 -SDRARRQAQQDRDEM-ADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSN-SELL 1772
Query: 154 RRQLTPYAQRMERVLRENADSLQASLRPHADELKAKIDQNVEELKGRLTPYADEFKVKID 213
+ ++E + E S + S A+ + ++++ ++EL+GRL + +
Sbjct: 1773 NDRYRKLLLQVESLTTEL--SAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHK 1830
Query: 214 QTVEELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELKARISASAEELRQRLAPLAED 273
T+ L LA + +++ ++ L+ ++ + AE+ + EE R+ L +
Sbjct: 1831 MTIAALESKLAQAEEQLEQETRERI--LSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQ 1888
Query: 274 V-RGNLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENFN---KALVQQMEQLRQKL 329
+ +GNLR + L++ L E + + RRR++ E+ +++ +++ LR +L
Sbjct: 1889 LEKGNLR--VKQLKRQLEEAEEEA-SRAQAGRRRLQRELEDVTESAESMNREVTTLRNRL 1945
Query: 330 GPHAGDVEGHLSFLEKDLR 348
G L+F + +R
Sbjct: 1946 R------RGPLTFTTRTVR 1958
Score = 41.2 bits (95), Expect = 0.002
Identities = 73/292 (25%), Positives = 115/292 (39%), Gaps = 60/292 (20%)
Query: 105 ELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVSTQAEQLRRQLTPYAQRM 164
E+ + RA+ L E+ Q+ + ELQ R+ QL + + AEQLR + A+
Sbjct: 869 EVLQARAQELQKVQELQQQSAREVGELQGRVA----QLEEERARLAEQLRAEAELCAEAE 924
Query: 165 ERVLRENADSLQASLRPHADELKAKIDQNVEELKGRLTPYADEFKVKIDQTVEELRRSLA 224
E R + + L EL+A++ + E + T K ++ Q ++EL L
Sbjct: 925 ET--RGRLAARKQELELVVSELEARVGEEEECSRQMQTE-----KKRLQQHIQELEAHLE 977
Query: 225 PYAQDTQEKLNHQLEGLTFQ--MKKNAEELKARISASAEELRQRLAPLAEDVRGNLRGNT 282
+ ++KL QLE +T + MKK E+L L ED L
Sbjct: 978 A-EEGARQKL--QLEKVTTEAKMKKFEEDLL----------------LLEDQNSKLSKER 1018
Query: 283 EGLQKSLAELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSF 342
+ L+ LAE ++ E+ V+ + +LR K D+E L
Sbjct: 1019 KLLEDRLAEFSSQAAEEEEK----------------VKSLNKLRLKYEATIADMEDRLRK 1062
Query: 343 LEKDLRDKVNSFFSTFKEKESQDKTLSLPELEQQQEQQQEQQQEQVQMLAPL 394
EK + E E + L E + QEQ EQQQ ++ A L
Sbjct: 1063 EEKGRQ-----------ELEKLKRRLD-GESSELQEQMVEQQQRAEELRAQL 1102
Score = 40.4 bits (93), Expect = 0.003
Identities = 87/405 (21%), Positives = 163/405 (40%), Gaps = 87/405 (21%)
Query: 50 QKSELTQQLNAL---FQDKLGEVNTYAGDLQKKLVPFATELHERLAKDS-------EKLK 99
Q+ +L ++L AL +D L N +L+ K TEL + L +++ ++L+
Sbjct: 1157 QRRDLGEELEALRGELEDTLDSTNAQQ-ELRSKREQEVTELKKTLEEETRIHEAAVQELR 1215
Query: 100 EEIGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVST------QAEQL 153
+ G+ L EL +L E +++ + + LE +LR ++S+ + EQ
Sbjct: 1216 QRHGQALGELAEQL-----EQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQR 1270
Query: 154 RRQLTPYAQRM-------ERVLRENADSLQAS------LRPHADELKAKIDQNVEELKGR 200
RR+L Q + ER E A+ LQ + + +E ++K + +EL
Sbjct: 1271 RRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSST 1330
Query: 201 LTPYADEFKVKIDQTVEELRRSLAPYAQDTQ---------------EKLNHQLEGLTFQM 245
D ++ ++T +L A + + E+ +L+ Q+
Sbjct: 1331 EAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQL 1390
Query: 246 KK-------------NAEELKARISASAEELRQRLAPLAEDVRGNLRGNTEGLQKSLAEL 292
+ EE + R + AE L QRLA E V RG LQ+ L +
Sbjct: 1391 SEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRR-LQQELDDA 1449
Query: 293 GGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDKVN 352
L+QQ + LV +E+ ++K + + + LR
Sbjct: 1450 TMDLEQQ----------------RQLVSTLEKKQRKFDQLLAEEKAAV------LRAVEE 1487
Query: 353 SFFSTFKEKESQDKTLSLPE-LEQQQEQQQEQQQEQVQMLAPLES 396
+ + +E + + LSL LE++QE ++E +++ + A LE+
Sbjct: 1488 RERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEA 1532
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 56.2 bits (134), Expect = 5e-08
Identities = 86/372 (23%), Positives = 167/372 (44%), Gaps = 46/372 (12%)
Query: 47 EHLQKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHER--LAKDSEKL------ 98
+ LQK + QQ +A ++GE+ L+++ A +L L ++E+
Sbjct: 917 QELQKVQELQQQSAR---EVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAA 973
Query: 99 -KEEIGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVSTQAEQLRRQL 157
K+E+ + EL AR+ E S+++ + LQQ ++ L + + + ++
Sbjct: 974 RKQELELVVSELEARV-GEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKV 1032
Query: 158 TPYAQRM----ERVLRENADSLQASLRPHADELKAKIDQNVEELKGRLTPYADEFKVKID 213
T A+ + +L E+ +S + R ++ A+ E + ++ ++ ++K +
Sbjct: 1033 TTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSL-NKLRLKYE 1091
Query: 214 QTVEELRRSLAPYAQDTQE--KLNHQLEGLTFQMKKN-------AEELKARISASAEELR 264
T+ ++ L + QE KL +L+G + ++++ AEEL+A++ EEL+
Sbjct: 1092 ATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQ 1151
Query: 265 QRLAPLAEDVRGNLRGNTEGLQKSLAELGGHLDQQVE--EFRRRVEPYGENFNKALVQQM 322
LA AED G R L KSL E L + E E R E + L +++
Sbjct: 1152 AALA-RAED-EGGARAQ---LLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEEL 1206
Query: 323 EQLRQKLGPHAGDVEGHL--SFLEKDLRDKVNSFFSTFK---EKESQDKTLSLPELEQQQ 377
E LR G++E L + +++LR K + K E+E++ ++ EL Q+
Sbjct: 1207 EALR-------GELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRH 1259
Query: 378 EQQQEQQQEQVQ 389
Q + EQ++
Sbjct: 1260 GQALGELAEQLE 1271
Score = 42.0 bits (97), Expect = 0.001
Identities = 67/319 (21%), Positives = 148/319 (46%), Gaps = 31/319 (9%)
Query: 43 KEAVEHLQKSELTQQLNALFQD------KLGEVNTYAGDLQKKLVPFATE---LHERLAK 93
+EAV+ L+K + Q+ L+++ E+ + + +K+L E L E LA
Sbjct: 1699 EEAVKQLRKMQA--QMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAA 1756
Query: 94 DSEKLKEEIGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVSTQAEQL 153
S++ + + ++ +E+ A + + N I + R+L+ RL ++L + S +E L
Sbjct: 1757 -SDRARRQAQQDRDEM-ADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSN-SELL 1813
Query: 154 RRQLTPYAQRMERVLRENADSLQASLRPHADELKAKIDQNVEELKGRLTPYADEFKVKID 213
+ ++E + E S + S A+ + ++++ ++EL+GRL + +
Sbjct: 1814 NDRYRKLLLQVESLTTEL--SAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHK 1871
Query: 214 QTVEELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELKARISASAEELRQRLAPLAED 273
T+ L LA + +++ ++ L+ ++ + AE+ + EE R+ L +
Sbjct: 1872 MTIAALESKLAQAEEQLEQETRERI--LSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQ 1929
Query: 274 V-RGNLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENFN---KALVQQMEQLRQKL 329
+ +GNLR + L++ L E + + RRR++ E+ +++ +++ LR +L
Sbjct: 1930 LEKGNLR--VKQLKRQLEEAEEEA-SRAQAGRRRLQRELEDVTESAESMNREVTTLRNRL 1986
Query: 330 GPHAGDVEGHLSFLEKDLR 348
G L+F + +R
Sbjct: 1987 R------RGPLTFTTRTVR 1999
Score = 41.2 bits (95), Expect = 0.002
Identities = 73/292 (25%), Positives = 115/292 (39%), Gaps = 60/292 (20%)
Query: 105 ELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVSTQAEQLRRQLTPYAQRM 164
E+ + RA+ L E+ Q+ + ELQ R+ QL + + AEQLR + A+
Sbjct: 910 EVLQARAQELQKVQELQQQSAREVGELQGRVA----QLEEERARLAEQLRAEAELCAEAE 965
Query: 165 ERVLRENADSLQASLRPHADELKAKIDQNVEELKGRLTPYADEFKVKIDQTVEELRRSLA 224
E R + + L EL+A++ + E + T K ++ Q ++EL L
Sbjct: 966 ET--RGRLAARKQELELVVSELEARVGEEEECSRQMQTE-----KKRLQQHIQELEAHLE 1018
Query: 225 PYAQDTQEKLNHQLEGLTFQ--MKKNAEELKARISASAEELRQRLAPLAEDVRGNLRGNT 282
+ ++KL QLE +T + MKK E+L L ED L
Sbjct: 1019 A-EEGARQKL--QLEKVTTEAKMKKFEEDLL----------------LLEDQNSKLSKER 1059
Query: 283 EGLQKSLAELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSF 342
+ L+ LAE ++ E+ V+ + +LR K D+E L
Sbjct: 1060 KLLEDRLAEFSSQAAEEEEK----------------VKSLNKLRLKYEATIADMEDRLRK 1103
Query: 343 LEKDLRDKVNSFFSTFKEKESQDKTLSLPELEQQQEQQQEQQQEQVQMLAPL 394
EK + E E + L E + QEQ EQQQ ++ A L
Sbjct: 1104 EEKGRQ-----------ELEKLKRRLD-GESSELQEQMVEQQQRAEELRAQL 1143
Score = 40.4 bits (93), Expect = 0.003
Identities = 87/405 (21%), Positives = 163/405 (40%), Gaps = 87/405 (21%)
Query: 50 QKSELTQQLNAL---FQDKLGEVNTYAGDLQKKLVPFATELHERLAKDS-------EKLK 99
Q+ +L ++L AL +D L N +L+ K TEL + L +++ ++L+
Sbjct: 1198 QRRDLGEELEALRGELEDTLDSTNAQQ-ELRSKREQEVTELKKTLEEETRIHEAAVQELR 1256
Query: 100 EEIGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVST------QAEQL 153
+ G+ L EL +L E +++ + + LE +LR ++S+ + EQ
Sbjct: 1257 QRHGQALGELAEQL-----EQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQR 1311
Query: 154 RRQLTPYAQRM-------ERVLRENADSLQAS------LRPHADELKAKIDQNVEELKGR 200
RR+L Q + ER E A+ LQ + + +E ++K + +EL
Sbjct: 1312 RRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSST 1371
Query: 201 LTPYADEFKVKIDQTVEELRRSLAPYAQDTQ---------------EKLNHQLEGLTFQM 245
D ++ ++T +L A + + E+ +L+ Q+
Sbjct: 1372 EAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQL 1431
Query: 246 KK-------------NAEELKARISASAEELRQRLAPLAEDVRGNLRGNTEGLQKSLAEL 292
+ EE + R + AE L QRLA E V RG LQ+ L +
Sbjct: 1432 SEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRR-LQQELDDA 1490
Query: 293 GGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDKVN 352
L+QQ + LV +E+ ++K + + + LR
Sbjct: 1491 TMDLEQQ----------------RQLVSTLEKKQRKFDQLLAEEKAAV------LRAVEE 1528
Query: 353 SFFSTFKEKESQDKTLSLPE-LEQQQEQQQEQQQEQVQMLAPLES 396
+ + +E + + LSL LE++QE ++E +++ + A LE+
Sbjct: 1529 RERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEA 1573
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 56.2 bits (134), Expect = 5e-08
Identities = 80/348 (22%), Positives = 153/348 (43%), Gaps = 62/348 (17%)
Query: 88 HERLAKDSEKLKE------EIGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQ 141
H++L ++ L E E+ E EE+RARL Q++ + L +L+ R+E ++
Sbjct: 882 HQQLLEEKNILAEQLQAETELFAEAEEMRARLAAK----KQELEEILHDLESRVE--EEE 935
Query: 142 LRTQVSTQAEQLRRQLTPYAQRMERVLRENADSLQ----------ASLRPHADELKAKID 191
R Q+ + ++++ + Q +E L E + Q A ++ +E+ D
Sbjct: 936 ERNQI---LQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLED 992
Query: 192 QN-----------------------VEELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQ 228
QN EE L ++ +V I E L++ +
Sbjct: 993 QNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKE--EKTR 1050
Query: 229 DTQEKLNHQLEGLTFQMKKNAEELKARISASAEELRQRLAPLAEDVRGNL-RGNTEGLQK 287
EK +L+G T ++ EL+A+I +EL+ +LA E+++G L RG+ E L K
Sbjct: 1051 QELEKAKRKLDGETTDLQDQIAELQAQI----DELKLQLAKKEEELQGALARGDDETLHK 1106
Query: 288 SLA-ELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHL--SFLE 344
+ A ++ L Q+ E + E + NKA +Q L ++L ++E L + +
Sbjct: 1107 NNALKVVRELQAQIAELQEDFESEKASRNKA-EKQKRDLSEELEALKTELEDTLDTTAAQ 1165
Query: 345 KDLRDKVNSFFSTFK---EKESQDKTLSLPELEQQQEQQQEQQQEQVQ 389
++LR K + K E+E+++ + ++ Q+ E+ EQ++
Sbjct: 1166 QELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLE 1213
Score = 55.8 bits (133), Expect = 6e-08
Identities = 96/434 (22%), Positives = 181/434 (41%), Gaps = 87/434 (20%)
Query: 38 LSNNAKEAVEHLQ--KSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDS 95
L N K+ H+Q + +L ++ A + +L +V A K+ E+ ++S
Sbjct: 941 LQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEA-----KIKKMEEEILLLEDQNS 995
Query: 96 EKLKEEIGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVSTQAEQLRR 155
+ +KE+ K +E+ A E +K NL +++ + E L ++ + E+ R+
Sbjct: 996 KFIKEK--KLMEDRIAECSSQLAEEEEK-AKNLAKIRNKQEVMISDLEERLKKE-EKTRQ 1051
Query: 156 QLTPYAQRMERVLRENADSLQASLRPHADELKAKIDQNVEELKGRLTPYADE--FKVKID 213
+L ++++ + D + A L+ DELK ++ + EEL+G L DE K
Sbjct: 1052 ELEKAKRKLDGETTDLQDQI-AELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNAL 1110
Query: 214 QTVEELRRSLAPYAQDTQEK-------------LNHQLEGL------------------- 241
+ V EL+ +A +D + + L+ +LE L
Sbjct: 1111 KVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRT 1170
Query: 242 -----TFQMKKNAEELKARISASAEELRQRLAPLAEDV----------RGNLRGNTEGLQ 286
++KK EE A +++RQR A E++ + NL N +GL+
Sbjct: 1171 KREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLE 1230
Query: 287 KSLAELGGHLD--QQV----EEFRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHL 340
EL + QQV E R++++ + + A V + ++LR +L A ++ L
Sbjct: 1231 TDNKELACEVKVLQQVKAESEHKRKKLDAQVQELH-AKVSEGDRLRVELAEKASKLQNEL 1289
Query: 341 ----SFLEK-------------DLRDKVNSFFSTFKEKESQDKTLS--LPELEQQQEQQQ 381
+ LE+ L ++ +E+ Q LS + +LE+++ Q
Sbjct: 1290 DNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQ 1349
Query: 382 EQQQEQVQMLAPLE 395
EQQ+E+ + LE
Sbjct: 1350 EQQEEEEEARKNLE 1363
Score = 48.1 bits (113), Expect = 1e-05
Identities = 83/376 (22%), Positives = 152/376 (40%), Gaps = 76/376 (20%)
Query: 43 KEAVEHLQKSELTQQLNAL-----FQDKLGEVNTYAGDLQKKLVPFATELHERLAKDS-- 95
+EA ++L+K L Q D LG + + + +KKL+ A L +RL + +
Sbjct: 1356 EEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLE-EAKKKLLKDAEALSQRLEEKALA 1414
Query: 96 ----EKLKEEIGKELEELRARLLPHANEVSQKIGDNLRELQQRLEP-------YADQLRT 144
EK K + +EL++L L H +V+ + ++ Q L YA++ R
Sbjct: 1415 YDKLEKTKNRLQQELDDLTVDL-DHQRQVASNLEKKQKKFDQLLAEEKSISARYAEE-RD 1472
Query: 145 QVSTQAEQLRRQLTPYAQRMERVL--RENADSLQASLRPHADEL---------------- 186
+ +A + + A+ +E L +E + LR ++L
Sbjct: 1473 RAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEK 1532
Query: 187 -KAKIDQNVEELKGRLTPYADEFKVKIDQTVE---ELRRSLAPYAQDTQEKLNHQLEGLT 242
K ++Q VEE++ +L DE + D + ++ A + +D Q + + Q E
Sbjct: 1533 SKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTR-DEQNEEKK 1591
Query: 243 FQMKKNAEELKARISASAEELRQRLAPLAEDVRGNLRGNTEGLQKSLAELGGHLDQQVEE 302
+ K EL+A + +E +QR +A +++E
Sbjct: 1592 RLLIKQVRELEAELE---DERKQRALAVAS------------------------KKKMEI 1624
Query: 303 FRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDKVNSFFSTFKEKE 362
+ +E E NKA + ++QLR KL D + L ++ R + F+ KE E
Sbjct: 1625 DLKDLEAQIEAANKARDEVIKQLR-KLQAQMKDYQREL----EEARASRDEIFAQSKESE 1679
Query: 363 SQDKTLSLPELEQQQE 378
+ K+L L+ Q+E
Sbjct: 1680 KKLKSLEAEILQLQEE 1695
Score = 46.6 bits (109), Expect = 4e-05
Identities = 58/252 (23%), Positives = 112/252 (44%), Gaps = 19/252 (7%)
Query: 47 EHLQKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSEKLKEEIGKEL 106
E L SE ++ +D+L + T + + L+ L R+A+ E+L+EE +
Sbjct: 1694 EELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEE-QSNM 1752
Query: 107 EELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVSTQAEQLRRQLTPYAQRMER 166
E L R +V + E + +D R Q+ Q ++L+ +L Q +E
Sbjct: 1753 ELLNDRFRKTTLQVDTLNAELAAE--RSAAQKSDNARQQLERQNKELKAKL----QELEG 1806
Query: 167 VLRENADSLQASLRPHADELKAKIDQNVEE--LKGRLTPYADEFKVKIDQTVEELRRSLA 224
++ + ++L +L+ +++Q +E +L ++ +I VE+ RR
Sbjct: 1807 AVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHAD 1866
Query: 225 PYAQDTQEKLNHQLEGLTFQMKKNAEELKARISASAEELRQRLAPLAEDVRGNLRGNTEG 284
Y ++ EK N +++ L Q+++ AEE R +AS +L++ L E EG
Sbjct: 1867 QY-KEQMEKANARMKQLKRQLEE-AEEEATRANASRRKLQRELDDATE--------ANEG 1916
Query: 285 LQKSLAELGGHL 296
L + ++ L L
Sbjct: 1917 LSREVSTLKNRL 1928
Score = 42.4 bits (98), Expect = 7e-04
Identities = 53/254 (20%), Positives = 107/254 (42%), Gaps = 24/254 (9%)
Query: 76 LQKKLVPFATEL--HERLAKDSEKLKEEIGKELEEL---RARLLPHANEVSQKIG---DN 127
L+ +++ EL ER + +E+ ++E+ E+ ++ LL + +I +
Sbjct: 1685 LEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEE 1744
Query: 128 LRELQQRLEPYADQLRTQVSTQAEQLRRQLTPYAQRMERVLRENADSLQASLRPHADELK 187
L E Q +E D+ R + + Q + L +L ER + +D+ + L ELK
Sbjct: 1745 LEEEQSNMELLNDRFR-KTTLQVDTLNAELAA-----ERSAAQKSDNARQQLERQNKELK 1798
Query: 188 AKIDQNVEELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQ--EKLNHQLEGLTFQM 245
AK+ + +K + + KI Q E+L + A + + +L+ + Q+
Sbjct: 1799 AKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQV 1858
Query: 246 ---KKNAEELKARISASAEELRQRLAPLAEDVRGNLRGNT--EGLQKSL---AELGGHLD 297
+++A++ K ++ + ++Q L E R N LQ+ L E L
Sbjct: 1859 EDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLS 1918
Query: 298 QQVEEFRRRVEPYG 311
++V + R+ G
Sbjct: 1919 REVSTLKNRLRRGG 1932
Score = 39.3 bits (90), Expect = 0.006
Identities = 53/220 (24%), Positives = 105/220 (47%), Gaps = 36/220 (16%)
Query: 184 DELKAKIDQNVEELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEK--LNHQLEGL 241
+EL+AK D+ + ++K + T K++ +EE+ R + Q +EK L QL+
Sbjct: 852 EELQAK-DEELLKVKEKQT--------KVEGELEEMERK---HQQLLEEKNILAEQLQAE 899
Query: 242 TFQMKKNAEELKARISASAEELRQRLAPLAEDVRGN------LRGNTEGLQKSLAELGGH 295
T ++ AEE++AR++A +EL + L L V L+ + +Q + +L
Sbjct: 900 T-ELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQ 958
Query: 296 LDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDKVNSFF 355
LD+ EE R+ + +A +++ME+ L D +K + D++
Sbjct: 959 LDE--EEGARQKLQLEKVTAEAKIKKMEEEILLL----EDQNSKFIKEKKLMEDRIAECS 1012
Query: 356 STFKEKESQDKTLS---------LPELEQQQEQQQEQQQE 386
S E+E + K L+ + +LE++ +++++ +QE
Sbjct: 1013 SQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQE 1052
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.128 0.338
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,744,824
Number of Sequences: 37866
Number of extensions: 579041
Number of successful extensions: 8680
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 145
Number of HSP's successfully gapped in prelim test: 730
Number of HSP's that attempted gapping in prelim test: 4289
Number of HSP's gapped (non-prelim): 2788
length of query: 396
length of database: 18,247,518
effective HSP length: 104
effective length of query: 292
effective length of database: 14,309,454
effective search space: 4178360568
effective search space used: 4178360568
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.