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Search of human proteins with 71274172
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|71274172 ankyrin repeat domain 56 [Homo sapiens]
(793 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|71274172 ankyrin repeat domain 56 [Homo sapiens] 1609 0.0
gi|95147559 ankyrin repeat domain 43 [Homo sapiens] 136 9e-32
gi|54607077 ankyrin repeat domain 57 [Homo sapiens] 122 1e-27
gi|157743267 ankyrin repeat domain 58 [Homo sapiens] 101 2e-21
gi|239753839 PREDICTED: hypothetical protein [Homo sapiens] 56 1e-07
gi|169161029 PREDICTED: hypothetical protein [Homo sapiens] 56 1e-07
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e... 55 3e-07
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d... 55 3e-07
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ... 55 3e-07
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ... 55 3e-07
gi|163965366 nascent polypeptide-associated complex alpha subuni... 54 7e-07
gi|110832843 TBP-associated factor 4 [Homo sapiens] 53 1e-06
gi|157504499 ankyrin repeat domain 47 [Homo sapiens] 53 1e-06
gi|38176283 ankyrin repeat and SOCS box-containing protein 7 iso... 53 1e-06
gi|24497554 homeobox A13 [Homo sapiens] 53 1e-06
gi|30089994 ankyrin repeat and SOCS box-containing protein 7 iso... 53 1e-06
gi|30795231 brain abundant, membrane attached signal protein 1 [... 52 2e-06
gi|148596917 fibronectin type III and ankyrin repeat domains 1 [... 52 2e-06
gi|239508698 PREDICTED: similar to mucin [Homo sapiens] 51 5e-06
gi|78042577 MAP7 domain containing 1 [Homo sapiens] 51 5e-06
gi|48762934 alpha 2 type I collagen [Homo sapiens] 50 6e-06
gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens] 50 8e-06
gi|110556636 tankyrase 1-binding protein 1 [Homo sapiens] 50 1e-05
gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiqu... 49 1e-05
gi|150170670 piccolo isoform 2 [Homo sapiens] 49 1e-05
gi|150378539 piccolo isoform 1 [Homo sapiens] 49 1e-05
gi|13540521 basic helix-loop-helix domain containing, class B, 3... 49 1e-05
gi|226509740 SR-related CTD-associated factor 1 [Homo sapiens] 49 2e-05
gi|17981699 cyclin-dependent kinase inhibitor 2C [Homo sapiens] 49 2e-05
gi|4502751 cyclin-dependent kinase inhibitor 2C [Homo sapiens] 49 2e-05
>gi|71274172 ankyrin repeat domain 56 [Homo sapiens]
Length = 793
Score = 1609 bits (4166), Expect = 0.0
Identities = 793/793 (100%), Positives = 793/793 (100%)
Query: 1 MARELSQEALLDFLCQAGGRVTNAALLSHFKSFLRDPDASPSQHQHRRELFKGFVNSVAA 60
MARELSQEALLDFLCQAGGRVTNAALLSHFKSFLRDPDASPSQHQHRRELFKGFVNSVAA
Sbjct: 1 MARELSQEALLDFLCQAGGRVTNAALLSHFKSFLRDPDASPSQHQHRRELFKGFVNSVAA 60
Query: 61 VRQDPDGTKYVVLKRRYRDLLGEEGLQRPREPPAAAPSAGGAAPCSPRGARRGEPPQQQP 120
VRQDPDGTKYVVLKRRYRDLLGEEGLQRPREPPAAAPSAGGAAPCSPRGARRGEPPQQQP
Sbjct: 61 VRQDPDGTKYVVLKRRYRDLLGEEGLQRPREPPAAAPSAGGAAPCSPRGARRGEPPQQQP 120
Query: 121 RRRRREKEPEEEPAGAAARAADAACNGLPGSDSRRAPGKGGGSKGSPGQRPPVPAAAAAG 180
RRRRREKEPEEEPAGAAARAADAACNGLPGSDSRRAPGKGGGSKGSPGQRPPVPAAAAAG
Sbjct: 121 RRRRREKEPEEEPAGAAARAADAACNGLPGSDSRRAPGKGGGSKGSPGQRPPVPAAAAAG 180
Query: 181 AQARASCAAAKTQGRCCWECLQNNLAVLPGELGALPHSATAEEKPARALPAQDDRGASRE 240
AQARASCAAAKTQGRCCWECLQNNLAVLPGELGALPHSATAEEKPARALPAQDDRGASRE
Sbjct: 181 AQARASCAAAKTQGRCCWECLQNNLAVLPGELGALPHSATAEEKPARALPAQDDRGASRE 240
Query: 241 REEGALAEPAPVPAVAHSPPATVEAATSRASPPALLPGPAPRGDRPELLTPSSLHYSTLQ 300
REEGALAEPAPVPAVAHSPPATVEAATSRASPPALLPGPAPRGDRPELLTPSSLHYSTLQ
Sbjct: 241 REEGALAEPAPVPAVAHSPPATVEAATSRASPPALLPGPAPRGDRPELLTPSSLHYSTLQ 300
Query: 301 QQQQRTREWVARHPQVPEARDQGPIRAWSVLPDNFLQLPLEPGSTEPNSEPPDPCLSSHS 360
QQQQRTREWVARHPQVPEARDQGPIRAWSVLPDNFLQLPLEPGSTEPNSEPPDPCLSSHS
Sbjct: 301 QQQQRTREWVARHPQVPEARDQGPIRAWSVLPDNFLQLPLEPGSTEPNSEPPDPCLSSHS 360
Query: 361 LFPVVPDESWESWAGNPSLTVFRSIRCQLSLQDLDDFVDQESDGSEESSSGPKDSPGASE 420
LFPVVPDESWESWAGNPSLTVFRSIRCQLSLQDLDDFVDQESDGSEESSSGPKDSPGASE
Sbjct: 361 LFPVVPDESWESWAGNPSLTVFRSIRCQLSLQDLDDFVDQESDGSEESSSGPKDSPGASE 420
Query: 421 EGLQVVLGTPDRGKLRNPAGGLSVSRKEGSPSRSPQGLRNRGDGHISQQVPAGANGLAGH 480
EGLQVVLGTPDRGKLRNPAGGLSVSRKEGSPSRSPQGLRNRGDGHISQQVPAGANGLAGH
Sbjct: 421 EGLQVVLGTPDRGKLRNPAGGLSVSRKEGSPSRSPQGLRNRGDGHISQQVPAGANGLAGH 480
Query: 481 PLKPLPWPVPKLRRSLRRSSLAGRAKLSSSDEEYLDEGLLKRSRRPPRSRKPSKAGTAPS 540
PLKPLPWPVPKLRRSLRRSSLAGRAKLSSSDEEYLDEGLLKRSRRPPRSRKPSKAGTAPS
Sbjct: 481 PLKPLPWPVPKLRRSLRRSSLAGRAKLSSSDEEYLDEGLLKRSRRPPRSRKPSKAGTAPS 540
Query: 541 PRVDAGLSLKLAEVKAVVAERGWRHSLWVPSGEGSAALAPHRTSEHKSSLVPLDAREHEW 600
PRVDAGLSLKLAEVKAVVAERGWRHSLWVPSGEGSAALAPHRTSEHKSSLVPLDAREHEW
Sbjct: 541 PRVDAGLSLKLAEVKAVVAERGWRHSLWVPSGEGSAALAPHRTSEHKSSLVPLDAREHEW 600
Query: 601 IVKLASGSWIQVWTLFWEDPQLALHKDFLTGYTALHWIAKHGDLRALQDLVSGAKKAGIV 660
IVKLASGSWIQVWTLFWEDPQLALHKDFLTGYTALHWIAKHGDLRALQDLVSGAKKAGIV
Sbjct: 601 IVKLASGSWIQVWTLFWEDPQLALHKDFLTGYTALHWIAKHGDLRALQDLVSGAKKAGIV 660
Query: 661 LDVNVRSSCGYTPLHLAAIHGHQGVIKLLVQRLASRVNVRDSSGKKPWQYLTSNTSGEIW 720
LDVNVRSSCGYTPLHLAAIHGHQGVIKLLVQRLASRVNVRDSSGKKPWQYLTSNTSGEIW
Sbjct: 661 LDVNVRSSCGYTPLHLAAIHGHQGVIKLLVQRLASRVNVRDSSGKKPWQYLTSNTSGEIW 720
Query: 721 QLLGAPRGKPIFPVYPLVGSSSPTRKAKSKEISRSVTRKTSFAALLKSQHNKWKLANQYE 780
QLLGAPRGKPIFPVYPLVGSSSPTRKAKSKEISRSVTRKTSFAALLKSQHNKWKLANQYE
Sbjct: 721 QLLGAPRGKPIFPVYPLVGSSSPTRKAKSKEISRSVTRKTSFAALLKSQHNKWKLANQYE 780
Query: 781 KFHSPREREEYSD 793
KFHSPREREEYSD
Sbjct: 781 KFHSPREREEYSD 793
>gi|95147559 ankyrin repeat domain 43 [Homo sapiens]
Length = 549
Score = 136 bits (342), Expect = 9e-32
Identities = 74/178 (41%), Positives = 105/178 (58%), Gaps = 1/178 (0%)
Query: 589 SLVPLDAREHEWIVKLASGSWI-QVWTLFWEDPQLALHKDFLTGYTALHWIAKHGDLRAL 647
S VPL+ EHEW+V+ A G W Q+ L D LA +DF++G+TALHW AK GD
Sbjct: 303 SAVPLEPSEHEWLVRTAGGRWTHQLHGLLLRDRGLAAKRDFMSGFTALHWAAKSGDGEMA 362
Query: 648 QDLVSGAKKAGIVLDVNVRSSCGYTPLHLAAIHGHQGVIKLLVQRLASRVNVRDSSGKKP 707
LV A+++G +DVN RS GYTPLHLAA+HGH+ LLV RL ++V+VRD SG++
Sbjct: 363 LQLVEVARRSGAPVDVNARSHGGYTPLHLAALHGHEDAAVLLVVRLGAQVHVRDHSGRRA 422
Query: 708 WQYLTSNTSGEIWQLLGAPRGKPIFPVYPLVGSSSPTRKAKSKEISRSVTRKTSFAAL 765
+QYL +S + +LLG P + G S + +++ ++ T+ A L
Sbjct: 423 YQYLRPGSSYALRRLLGDPGLRGTTEPDATGGGSGSLAARRPVQVAATILSSTTSAFL 480
Score = 74.7 bits (182), Expect = 3e-13
Identities = 67/190 (35%), Positives = 86/190 (45%), Gaps = 19/190 (10%)
Query: 2 ARELSQEALLDFLCQAGGRVTNAALLSHFKSFLRDPDASPSQHQHRRELFKGFVNSVAAV 61
A +SQ A+L FL + GG+V N+ LLS FK L D P RR+ FK FVN+VA V
Sbjct: 11 AAGVSQAAVLGFLQEHGGKVRNSELLSRFKPLLDAGD--PRGRAARRDRFKQFVNNVAVV 68
Query: 62 RQDPDGTKYVVLKRRYRDLLGEEGLQRPREPPAAAPSAGGAAPCSPRGARR-GEPPQQQP 120
+ + DG K+VVL+++ R E P P AAA + + PR A G PP
Sbjct: 69 K-ELDGVKFVVLRKKPRPPEPEPAPFGP--PGAAAQPSKPTSTVLPRSASAPGAPPLV-- 123
Query: 121 RRRRREKEPEEEPAGAAARAADAACNGLPGSDSRRAPGKGGGSKGSPGQRPPVPAAAAAG 180
R P E P G P S+ + PG+ PP+PA A
Sbjct: 124 ----RVPRPVEPPGDLGLPTEPQDTPGGPASEPAQPPGERSAD-------PPLPALELAQ 172
Query: 181 AQARASCAAA 190
A R S AA
Sbjct: 173 ATERPSADAA 182
>gi|54607077 ankyrin repeat domain 57 [Homo sapiens]
Length = 525
Score = 122 bits (306), Expect = 1e-27
Identities = 66/157 (42%), Positives = 96/157 (61%), Gaps = 3/157 (1%)
Query: 572 GEGSAALAPHRTSEHKSS---LVPLDAREHEWIVKLASGSWIQVWTLFWEDPQLALHKDF 628
G+ +A ++E +SS V LD EH W++ + G W + L +P L + +DF
Sbjct: 240 GDSDSASVASSSAEEESSGGGSVTLDPLEHAWMLSASDGKWDSLEGLLTCEPGLLVKRDF 299
Query: 629 LTGYTALHWIAKHGDLRALQDLVSGAKKAGIVLDVNVRSSCGYTPLHLAAIHGHQGVIKL 688
+TG+T LHW AKHG L LV+ A K + ++++ R+S GYT LHLAA+HGH V+KL
Sbjct: 300 ITGFTCLHWAAKHGRQELLAMLVNFANKHQLPVNIDARTSGGYTALHLAAMHGHVEVVKL 359
Query: 689 LVQRLASRVNVRDSSGKKPWQYLTSNTSGEIWQLLGA 725
LV + V++RD SGKK QYL+ + + EI L+GA
Sbjct: 360 LVGAYDADVDIRDYSGKKASQYLSRSIAEEIKNLVGA 396
Score = 69.7 bits (169), Expect = 1e-11
Identities = 62/177 (35%), Positives = 76/177 (42%), Gaps = 41/177 (23%)
Query: 5 LSQEALLDFLCQAGGRVTNAALLSHFKSFLRDPDASPSQHQHRRELFKGFVNSVAAVRQD 64
L EA+L FL + GGR +A L+ HF+ L P Q R FK VN+VA VR D
Sbjct: 13 LGPEAVLRFLAERGGRALHAELVQHFRGAL---GGEPEQRARARAHFKELVNAVATVRVD 69
Query: 65 P-DGTKYVVLKRRYRDLLGEEGLQRPREPPAAAPSAGGAAPCSPRGARRGEPPQQQPRRR 123
P DG KYV LK+R+ + P EP G+PP+ Q
Sbjct: 70 PADGAKYVHLKKRF--------CEGPSEP-------------------SGDPPRIQV--- 99
Query: 124 RREKEPEEEPAGAAA--RAADAAC-NGLPGSDSRRAPGKGGGSKGSPGQRPPVPAAA 177
E E + PAG A R DAA LPG G G +P PP+ A A
Sbjct: 100 TAEPEAPDGPAGPEARDRLPDAAAPESLPGQGRE----LGEGEPPAPAHWPPLSAGA 152
>gi|157743267 ankyrin repeat domain 58 [Homo sapiens]
Length = 315
Score = 101 bits (252), Expect = 2e-21
Identities = 65/172 (37%), Positives = 86/172 (50%), Gaps = 18/172 (10%)
Query: 559 AERGW-----RHSLWVPSGEGSAALAPHRTSEHKSSLVPLDAREHEWIVKLASGSWIQVW 613
A GW L PSG GS+ L L+ REH WI+ A G + +
Sbjct: 84 APAGWLSEERAEELGGPSGPGSSRLC-------------LEPREHAWILAAAEGRYEVLR 130
Query: 614 TLFWEDPQLALHKDFLTGYTALHWIAKHGDLRALQDLVSGAKKAGIVLDVNVRSSCGYTP 673
L +P+L L D +TGY+ LHW+AKHG L + A + G+ LDV+ S G TP
Sbjct: 131 ELLEAEPELLLRGDPITGYSVLHWLAKHGRHEELILVHDFALRRGLRLDVSAPGSGGLTP 190
Query: 674 LHLAAIHGHQGVIKLLVQRLASRVNVRDSSGKKPWQYLTSNTSGEIWQLLGA 725
LHLAA+ GH VIK+LV L + RD SG + YL + + +L GA
Sbjct: 191 LHLAALQGHDMVIKVLVGALGADATRRDHSGHRACHYLRPDAPWRLRELSGA 242
>gi|239753839 PREDICTED: hypothetical protein [Homo sapiens]
Length = 257
Score = 55.8 bits (133), Expect = 1e-07
Identities = 64/216 (29%), Positives = 82/216 (37%), Gaps = 31/216 (14%)
Query: 76 RYRDLLGEEGLQRPREPPAAAPSA---------GGAAPCSPRGARRGEPPQQQPRRRRRE 126
RY+ LG G +R PP AP+A G C P + PP + R R
Sbjct: 38 RYQKTLGPAGARRGHSPPTVAPAASAGSQEHPGAGGPLCFPARSAAWGPPARASRAAGRR 97
Query: 127 KEPEEEPAGAAARAADAACNGLPGSDSRRAPGKGGGSKGSPGQRPPVPAAAAAGAQARAS 186
P P A R AA +RR+P G ++GSP A AA + S
Sbjct: 98 AGPAGPPCRAPGRGRAAA--------TRRSPAP-GTARGSPAGVERAGGATAASSAGTRS 148
Query: 187 CAAAKTQGRCCWECLQNNLAVL--PGELGALPHSATAEEKPARALPAQDDRGASREREEG 244
A + C L L PG ALP S ++ + A A+P GA R G
Sbjct: 149 VPARRLPPPCGGTSLGAGSRALRRPGS-AALPRSPSSSRRWA-AMPGP---GAPRPGAPG 203
Query: 245 ALAEPAPVPAVAHSPPATVEAATSRASPPALLPGPA 280
PV +PPA AA+ PPA+ PA
Sbjct: 204 TW----PVGFAVAAPPAA--AASVAPPPPAVAGAPA 233
>gi|169161029 PREDICTED: hypothetical protein [Homo sapiens]
Length = 268
Score = 55.8 bits (133), Expect = 1e-07
Identities = 62/193 (32%), Positives = 78/193 (40%), Gaps = 18/193 (9%)
Query: 90 REPPAAAPSAGGAAPCSPRGARRGEPPQQQPRRRRREKEPEEEPAGAAARAADAACNGLP 149
RE + GG +PR A G P+ + +R RR + A+ C
Sbjct: 64 REGSPGVSAQGGPLEGTPRPAAPGAAPRPRRQRLRRRR----------AKVGGWGCARAR 113
Query: 150 GSDSRRAPGKGGGSKGSPGQRPPVPAAAAAGAQARASCAAAKTQGRCCWECLQNNLAVLP 209
G D RRAPG+GG S G G P P A A A A+ K +GR Q L VLP
Sbjct: 114 GLD-RRAPGEGGRSPG--GGLEPSPGARGAVGAAPAAARHRKPRGR-SRRAPQMPLRVLP 169
Query: 210 GELGALPHSATAEEKPARALPAQDDRGASREREEGALAEPAPVPAVAHSP-PATVEAATS 268
L L + A R LP + + A+ P VP++ P A AAT
Sbjct: 170 PILPGLSRAGGA--TGGRGLPGRRGLPGRSGLQGAAVPPPVGVPSLRGRPWEALATAATP 227
Query: 269 RASPPALL-PGPA 280
R P LL GPA
Sbjct: 228 RRCPLQLLRAGPA 240
Score = 33.1 bits (74), Expect = 1.0
Identities = 39/132 (29%), Positives = 47/132 (35%), Gaps = 13/132 (9%)
Query: 75 RRYRDLLGEEGLQRPREPPAAAPSAGGAAP---CSPRGARRGEPPQQQPRRRRREKEPEE 131
RR R +G G R R AP GG +P P RG R R
Sbjct: 98 RRRRAKVGGWGCARARGLDRRAPGEGGRSPGGGLEPSPGARGAVGAAPAAARHR------ 151
Query: 132 EPAGAAARAADAACNGLPG--SDSRRAPGKGGGSKGSPGQRPPVPAAAAAGAQARASCAA 189
+P G + RA LP RA G GG +G PG+R + GA
Sbjct: 152 KPRGRSRRAPQMPLRVLPPILPGLSRAGGATGG-RGLPGRRGLPGRSGLQGAAVPPPVGV 210
Query: 190 AKTQGRCCWECL 201
+GR WE L
Sbjct: 211 PSLRGR-PWEAL 221
>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
[Homo sapiens]
Length = 1451
Score = 54.7 bits (130), Expect = 3e-07
Identities = 99/498 (19%), Positives = 160/498 (32%), Gaps = 99/498 (19%)
Query: 90 REPPA--AAPSAGGAAPCSPRGARRGEPPQQQPRRRRREKEPEEE--------PAGAAA- 138
+E PA AAP+ G +P+ PP ++ ++ E E EE PAG +
Sbjct: 231 KESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQ 290
Query: 139 ----------RAADAACNGLPGSDSRRA-PGKGGG-----SKGSPGQRPPVPAAAAAGAQ 182
RAA A G PG + A PGK G G P + + ++ ++
Sbjct: 291 VKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSE 350
Query: 183 ARASCAAAKTQGRCCWECLQNNLAVLPGELGALPHSATAEEKPARALPA---------QD 233
A A Q + + Q A P + P A P + PA ++
Sbjct: 351 EETPAAKALLQAKASGKTSQVGAASAPAK--ESPRKGAAPAPPGKTGPAVAKAQAGKREE 408
Query: 234 DRGASREREEGALAEPAPVPAVAHSPPATVEAATSRASPPALLPGPAPRGDRPELLTPSS 293
D +S E + PA +P +A ++ SP G AP R +
Sbjct: 409 DSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESP---RKGAAPAPPRKTGPAAAQ 465
Query: 294 LHYSTLQQQQQRTREWVARHPQVPEARDQGPIRAWSVLPDNFLQLPLEPGSTEPNSEPPD 353
+ ++ + + E + A + ++ P + G + P
Sbjct: 466 VQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVP 525
Query: 354 PCLSSHSLFPVVPDESWESWAGNPSLTVFRSIRCQLSLQDLDDFVDQESDGSEESSSGPK 413
P + P P W D ES E S S
Sbjct: 526 P----GKVGPATPSAQVGKWE-----------------------EDSESSSEESSDSSDG 558
Query: 414 DSPGASEEGLQVVLGT-----PDRGKLRNP---AGGLSVSRKEGSPSRSPQGLRNRGDGH 465
+ P A + LG P + P AG ++V K P + + D
Sbjct: 559 EVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSA 618
Query: 466 ISQQVPAGANGLAGHPLKPLPWPVPKLRRSLRRSSLAGRAKLSSSDEEYLDEGLLKRSRR 525
S++ PA P +P+ + ++++ AK++
Sbjct: 619 DSEEAPAAMTAAQAKP----ALKIPQTKACPKKTNTTASAKVA----------------- 657
Query: 526 PPR--SRKPSKAGTAPSP 541
P R ++ P KAGTA SP
Sbjct: 658 PVRVGTQAPRKAGTATSP 675
Score = 35.4 bits (80), Expect = 0.21
Identities = 46/185 (24%), Positives = 69/185 (37%), Gaps = 38/185 (20%)
Query: 399 DQESDGSEESSSGPKDSPG-------ASEEGLQV------VLGTPDRGKLRNP---AGGL 442
++ES+ SEE S +++P ASE+ LQV GTP +G P AG +
Sbjct: 267 EEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAV 326
Query: 443 SVSRKEGSPSRSPQG------------------LRNRGDGHISQQVPAGANGLAGHPLKP 484
+ K G P + L+ + G SQ A A
Sbjct: 327 ASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGA 386
Query: 485 LPWPVPKLRRSLRRSSLAGRAKLSSSDEEYLDEGLLKRSRRPPRSRKPS-KAGTAP---S 540
P P K ++ ++ R + S S E D ++ P + P +A +AP S
Sbjct: 387 APAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKES 446
Query: 541 PRVDA 545
PR A
Sbjct: 447 PRKGA 451
Score = 32.3 bits (72), Expect = 1.8
Identities = 53/214 (24%), Positives = 76/214 (35%), Gaps = 32/214 (14%)
Query: 87 QRPREPPAA-APSAGG-----------AAPCSPRGARRGEPPQQQPRRRR-REKEPEEEP 133
Q P AA APSA G AA R + +PP + P+ + P P
Sbjct: 789 QAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVP 848
Query: 134 AGAAARAADAACNGLPGSDSRRAPGKGGGSKGSPGQRPPVPAAAAAGAQARASCAAAKTQ 193
+ A A A P DS + + + + P+ Q RA+ A AK
Sbjct: 849 SVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTH--QIRAALAPAKES 906
Query: 194 GRCCWECLQNNLAVLPGELGALPHSATAEEKPARALPAQDDRGASREREEGALAEPAPVP 253
R + PG+ G P +A A + QDD G+S E + PA V
Sbjct: 907 PR------KGAAPTPPGKTG--PSAAQAGK--------QDDSGSSSEESDSDGEAPAAVT 950
Query: 254 AVAHSPPATVEAATSRA-SPPALLPGPAPRGDRP 286
+ P + +R+ + PA P A P
Sbjct: 951 SAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTP 984
>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
[Homo sapiens]
Length = 1488
Score = 54.7 bits (130), Expect = 3e-07
Identities = 99/498 (19%), Positives = 160/498 (32%), Gaps = 99/498 (19%)
Query: 90 REPPA--AAPSAGGAAPCSPRGARRGEPPQQQPRRRRREKEPEEE--------PAGAAA- 138
+E PA AAP+ G +P+ PP ++ ++ E E EE PAG +
Sbjct: 231 KESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQ 290
Query: 139 ----------RAADAACNGLPGSDSRRA-PGKGGG-----SKGSPGQRPPVPAAAAAGAQ 182
RAA A G PG + A PGK G G P + + ++ ++
Sbjct: 291 VKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSE 350
Query: 183 ARASCAAAKTQGRCCWECLQNNLAVLPGELGALPHSATAEEKPARALPA---------QD 233
A A Q + + Q A P + P A P + PA ++
Sbjct: 351 EETPAAKALLQAKASGKTSQVGAASAPAK--ESPRKGAAPAPPGKTGPAVAKAQAGKREE 408
Query: 234 DRGASREREEGALAEPAPVPAVAHSPPATVEAATSRASPPALLPGPAPRGDRPELLTPSS 293
D +S E + PA +P +A ++ SP G AP R +
Sbjct: 409 DSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESP---RKGAAPAPPRKTGPAAAQ 465
Query: 294 LHYSTLQQQQQRTREWVARHPQVPEARDQGPIRAWSVLPDNFLQLPLEPGSTEPNSEPPD 353
+ ++ + + E + A + ++ P + G + P
Sbjct: 466 VQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVP 525
Query: 354 PCLSSHSLFPVVPDESWESWAGNPSLTVFRSIRCQLSLQDLDDFVDQESDGSEESSSGPK 413
P + P P W D ES E S S
Sbjct: 526 P----GKVGPATPSAQVGKWE-----------------------EDSESSSEESSDSSDG 558
Query: 414 DSPGASEEGLQVVLGT-----PDRGKLRNP---AGGLSVSRKEGSPSRSPQGLRNRGDGH 465
+ P A + LG P + P AG ++V K P + + D
Sbjct: 559 EVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSA 618
Query: 466 ISQQVPAGANGLAGHPLKPLPWPVPKLRRSLRRSSLAGRAKLSSSDEEYLDEGLLKRSRR 525
S++ PA P +P+ + ++++ AK++
Sbjct: 619 DSEEAPAAMTAAQAKP----ALKIPQTKACPKKTNTTASAKVA----------------- 657
Query: 526 PPR--SRKPSKAGTAPSP 541
P R ++ P KAGTA SP
Sbjct: 658 PVRVGTQAPRKAGTATSP 675
Score = 35.4 bits (80), Expect = 0.21
Identities = 46/185 (24%), Positives = 69/185 (37%), Gaps = 38/185 (20%)
Query: 399 DQESDGSEESSSGPKDSPG-------ASEEGLQV------VLGTPDRGKLRNP---AGGL 442
++ES+ SEE S +++P ASE+ LQV GTP +G P AG +
Sbjct: 267 EEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAV 326
Query: 443 SVSRKEGSPSRSPQG------------------LRNRGDGHISQQVPAGANGLAGHPLKP 484
+ K G P + L+ + G SQ A A
Sbjct: 327 ASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGA 386
Query: 485 LPWPVPKLRRSLRRSSLAGRAKLSSSDEEYLDEGLLKRSRRPPRSRKPS-KAGTAP---S 540
P P K ++ ++ R + S S E D ++ P + P +A +AP S
Sbjct: 387 APAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKES 446
Query: 541 PRVDA 545
PR A
Sbjct: 447 PRKGA 451
Score = 34.3 bits (77), Expect = 0.46
Identities = 76/355 (21%), Positives = 127/355 (35%), Gaps = 50/355 (14%)
Query: 93 PAAAPSAGGAAPCSPRGARRGEPPQQQPRRRRREKEPEEEPAGAAARAADAACNGLPGSD 152
PA+ PS G A + + A+ G P++ E + EEE A + + +
Sbjct: 844 PASVPSVGKAVATAAQ-AQTG--PEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAA- 899
Query: 153 SRRAPGKGGGSKGSPGQRPPV--PAAAAAGAQARASCAAAKTQGRCCWECLQNNLAVLPG 210
AP K KG+ P P+AA AG Q + ++ ++ G
Sbjct: 900 --LAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDS--------------DG 943
Query: 211 ELGALPHSATAEEKPARALPAQDDRGASREREEGALAEPAPVPAVAHSPPATVEAATSRA 270
E A SA + P + +R + A A+ A P A + +T +++S +
Sbjct: 944 EAPAAVTSAQVIKPPL--IFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSES 1001
Query: 271 SPPALLPGPA--PRGDRPELLTPSSLHYSTLQQQQQRTREWVARHPQVPEARDQ-GPIRA 327
++P G R ++T + H + ++ + + Q GP A
Sbjct: 1002 EDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGP--A 1059
Query: 328 WSVLPDNFLQLPLEPGSTE------PNSEPP----DPCLSSHSLFPVVPDESWESWAGNP 377
V N LPL + + ++PP P S +P S +S +
Sbjct: 1060 TQVSKKNPASLPLTQAALKVLAQKASEAQPPVARTQPSSGVDSAVGTLPATSPQSTSVQA 1119
Query: 378 SLT----------VFRSIRCQLSLQDLDDFVDQESDGSEESSSGPKDSPGASEEG 422
T V ++ + S D +D D S GSEE GP+ + A G
Sbjct: 1120 KGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSS-GSEEDGEGPQGAKSAHTLG 1173
Score = 32.3 bits (72), Expect = 1.8
Identities = 53/214 (24%), Positives = 76/214 (35%), Gaps = 32/214 (14%)
Query: 87 QRPREPPAA-APSAGG-----------AAPCSPRGARRGEPPQQQPRRRR-REKEPEEEP 133
Q P AA APSA G AA R + +PP + P+ + P P
Sbjct: 789 QAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVP 848
Query: 134 AGAAARAADAACNGLPGSDSRRAPGKGGGSKGSPGQRPPVPAAAAAGAQARASCAAAKTQ 193
+ A A A P DS + + + + P+ Q RA+ A AK
Sbjct: 849 SVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTH--QIRAALAPAKES 906
Query: 194 GRCCWECLQNNLAVLPGELGALPHSATAEEKPARALPAQDDRGASREREEGALAEPAPVP 253
R + PG+ G P +A A + QDD G+S E + PA V
Sbjct: 907 PR------KGAAPTPPGKTG--PSAAQAGK--------QDDSGSSSEESDSDGEAPAAVT 950
Query: 254 AVAHSPPATVEAATSRA-SPPALLPGPAPRGDRP 286
+ P + +R+ + PA P A P
Sbjct: 951 SAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTP 984
>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a
[Homo sapiens]
Length = 1450
Score = 54.7 bits (130), Expect = 3e-07
Identities = 99/498 (19%), Positives = 160/498 (32%), Gaps = 99/498 (19%)
Query: 90 REPPA--AAPSAGGAAPCSPRGARRGEPPQQQPRRRRREKEPEEE--------PAGAAA- 138
+E PA AAP+ G +P+ PP ++ ++ E E EE PAG +
Sbjct: 231 KESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQ 290
Query: 139 ----------RAADAACNGLPGSDSRRA-PGKGGG-----SKGSPGQRPPVPAAAAAGAQ 182
RAA A G PG + A PGK G G P + + ++ ++
Sbjct: 291 VKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSE 350
Query: 183 ARASCAAAKTQGRCCWECLQNNLAVLPGELGALPHSATAEEKPARALPA---------QD 233
A A Q + + Q A P + P A P + PA ++
Sbjct: 351 EETPAAKALLQAKASGKTSQVGAASAPAK--ESPRKGAAPAPPGKTGPAVAKAQAGKREE 408
Query: 234 DRGASREREEGALAEPAPVPAVAHSPPATVEAATSRASPPALLPGPAPRGDRPELLTPSS 293
D +S E + PA +P +A ++ SP G AP R +
Sbjct: 409 DSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESP---RKGAAPAPPRKTGPAAAQ 465
Query: 294 LHYSTLQQQQQRTREWVARHPQVPEARDQGPIRAWSVLPDNFLQLPLEPGSTEPNSEPPD 353
+ ++ + + E + A + ++ P + G + P
Sbjct: 466 VQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVP 525
Query: 354 PCLSSHSLFPVVPDESWESWAGNPSLTVFRSIRCQLSLQDLDDFVDQESDGSEESSSGPK 413
P + P P W D ES E S S
Sbjct: 526 P----GKVGPATPSAQVGKWE-----------------------EDSESSSEESSDSSDG 558
Query: 414 DSPGASEEGLQVVLGT-----PDRGKLRNP---AGGLSVSRKEGSPSRSPQGLRNRGDGH 465
+ P A + LG P + P AG ++V K P + + D
Sbjct: 559 EVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSA 618
Query: 466 ISQQVPAGANGLAGHPLKPLPWPVPKLRRSLRRSSLAGRAKLSSSDEEYLDEGLLKRSRR 525
S++ PA P +P+ + ++++ AK++
Sbjct: 619 DSEEAPAAMTAAQAKP----ALKIPQTKACPKKTNTTASAKVA----------------- 657
Query: 526 PPR--SRKPSKAGTAPSP 541
P R ++ P KAGTA SP
Sbjct: 658 PVRVGTQAPRKAGTATSP 675
Score = 35.4 bits (80), Expect = 0.21
Identities = 46/185 (24%), Positives = 69/185 (37%), Gaps = 38/185 (20%)
Query: 399 DQESDGSEESSSGPKDSPG-------ASEEGLQV------VLGTPDRGKLRNP---AGGL 442
++ES+ SEE S +++P ASE+ LQV GTP +G P AG +
Sbjct: 267 EEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAV 326
Query: 443 SVSRKEGSPSRSPQG------------------LRNRGDGHISQQVPAGANGLAGHPLKP 484
+ K G P + L+ + G SQ A A
Sbjct: 327 ASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGA 386
Query: 485 LPWPVPKLRRSLRRSSLAGRAKLSSSDEEYLDEGLLKRSRRPPRSRKPS-KAGTAP---S 540
P P K ++ ++ R + S S E D ++ P + P +A +AP S
Sbjct: 387 APAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKES 446
Query: 541 PRVDA 545
PR A
Sbjct: 447 PRKGA 451
Score = 32.3 bits (72), Expect = 1.8
Identities = 53/214 (24%), Positives = 76/214 (35%), Gaps = 32/214 (14%)
Query: 87 QRPREPPAA-APSAGG-----------AAPCSPRGARRGEPPQQQPRRRR-REKEPEEEP 133
Q P AA APSA G AA R + +PP + P+ + P P
Sbjct: 789 QAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVP 848
Query: 134 AGAAARAADAACNGLPGSDSRRAPGKGGGSKGSPGQRPPVPAAAAAGAQARASCAAAKTQ 193
+ A A A P DS + + + + P+ Q RA+ A AK
Sbjct: 849 SVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTH--QIRAALAPAKES 906
Query: 194 GRCCWECLQNNLAVLPGELGALPHSATAEEKPARALPAQDDRGASREREEGALAEPAPVP 253
R + PG+ G P +A A + QDD G+S E + PA V
Sbjct: 907 PR------KGAAPTPPGKTG--PSAAQAGK--------QDDSGSSSEESDSDGEAPAAVT 950
Query: 254 AVAHSPPATVEAATSRA-SPPALLPGPAPRGDRP 286
+ P + +R+ + PA P A P
Sbjct: 951 SAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTP 984
>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c
[Homo sapiens]
Length = 958
Score = 54.7 bits (130), Expect = 3e-07
Identities = 99/498 (19%), Positives = 160/498 (32%), Gaps = 99/498 (19%)
Query: 90 REPPA--AAPSAGGAAPCSPRGARRGEPPQQQPRRRRREKEPEEE--------PAGAAA- 138
+E PA AAP+ G +P+ PP ++ ++ E E EE PAG +
Sbjct: 231 KESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQ 290
Query: 139 ----------RAADAACNGLPGSDSRRA-PGKGGG-----SKGSPGQRPPVPAAAAAGAQ 182
RAA A G PG + A PGK G G P + + ++ ++
Sbjct: 291 VKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSE 350
Query: 183 ARASCAAAKTQGRCCWECLQNNLAVLPGELGALPHSATAEEKPARALPA---------QD 233
A A Q + + Q A P + P A P + PA ++
Sbjct: 351 EETPAAKALLQAKASGKTSQVGAASAPAK--ESPRKGAAPAPPGKTGPAVAKAQAGKREE 408
Query: 234 DRGASREREEGALAEPAPVPAVAHSPPATVEAATSRASPPALLPGPAPRGDRPELLTPSS 293
D +S E + PA +P +A ++ SP G AP R +
Sbjct: 409 DSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESP---RKGAAPAPPRKTGPAAAQ 465
Query: 294 LHYSTLQQQQQRTREWVARHPQVPEARDQGPIRAWSVLPDNFLQLPLEPGSTEPNSEPPD 353
+ ++ + + E + A + ++ P + G + P
Sbjct: 466 VQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVP 525
Query: 354 PCLSSHSLFPVVPDESWESWAGNPSLTVFRSIRCQLSLQDLDDFVDQESDGSEESSSGPK 413
P + P P W D ES E S S
Sbjct: 526 P----GKVGPATPSAQVGKWE-----------------------EDSESSSEESSDSSDG 558
Query: 414 DSPGASEEGLQVVLGT-----PDRGKLRNP---AGGLSVSRKEGSPSRSPQGLRNRGDGH 465
+ P A + LG P + P AG ++V K P + + D
Sbjct: 559 EVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSA 618
Query: 466 ISQQVPAGANGLAGHPLKPLPWPVPKLRRSLRRSSLAGRAKLSSSDEEYLDEGLLKRSRR 525
S++ PA P +P+ + ++++ AK++
Sbjct: 619 DSEEAPAAMTAAQAKP----ALKIPQTKACPKKTNTTASAKVA----------------- 657
Query: 526 PPR--SRKPSKAGTAPSP 541
P R ++ P KAGTA SP
Sbjct: 658 PVRVGTQAPRKAGTATSP 675
Score = 35.4 bits (80), Expect = 0.21
Identities = 46/185 (24%), Positives = 69/185 (37%), Gaps = 38/185 (20%)
Query: 399 DQESDGSEESSSGPKDSPG-------ASEEGLQV------VLGTPDRGKLRNP---AGGL 442
++ES+ SEE S +++P ASE+ LQV GTP +G P AG +
Sbjct: 267 EEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAV 326
Query: 443 SVSRKEGSPSRSPQG------------------LRNRGDGHISQQVPAGANGLAGHPLKP 484
+ K G P + L+ + G SQ A A
Sbjct: 327 ASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGA 386
Query: 485 LPWPVPKLRRSLRRSSLAGRAKLSSSDEEYLDEGLLKRSRRPPRSRKPS-KAGTAP---S 540
P P K ++ ++ R + S S E D ++ P + P +A +AP S
Sbjct: 387 APAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKES 446
Query: 541 PRVDA 545
PR A
Sbjct: 447 PRKGA 451
>gi|163965366 nascent polypeptide-associated complex alpha subunit
isoform a [Homo sapiens]
Length = 2078
Score = 53.5 bits (127), Expect = 7e-07
Identities = 64/229 (27%), Positives = 81/229 (35%), Gaps = 31/229 (13%)
Query: 85 GLQRPREPPAAAPSAGGAAPCSPRGARRGEPPQQQPRRRRREKEPEEEPAGAAARAADAA 144
GL P PP AP+ A P SP+G PP+ P P P A +
Sbjct: 1139 GLATP--PPKGAPTTPAATPPSPKGGLATPPPKGAP------TTPAATPPSPKGGLATPS 1190
Query: 145 CNGLPGSDSRRAPG-KGGGSKGSPGQRPPVPAA---AAAGAQARASCAAAKTQGRCCWEC 200
G P + + P KGG + SP P PAA + G A S A T
Sbjct: 1191 PKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPS 1250
Query: 201 LQNNLAVLPGELGALPHSAT--------------AEEKPARALPAQDDRGASREREEGAL 246
+ A P + P +AT PA P G + +GA
Sbjct: 1251 PKGGPATPPPKGAPTPPAATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAP 1310
Query: 247 AEPAPVPAVAHSPPATVEAATSRASPPALLPGPAPRGDRPEL--LTPSS 293
PA P P T +PPA+ P P+P+G P L TPSS
Sbjct: 1311 TPPAATPPSPKGSPGT-PPPKGAPTPPAVTP-PSPKG-TPTLPATTPSS 1356
Score = 48.5 bits (114), Expect = 2e-05
Identities = 65/217 (29%), Positives = 79/217 (36%), Gaps = 28/217 (12%)
Query: 85 GLQRPREPPAAAPSAGGAAPCSPRGARRGEPPQQQPRRRRREKEPEEEPAGAAARAADAA 144
GL P P AP+ A P SP+G PP+ P P P A
Sbjct: 1116 GLATP--PHKGAPTTPAATPPSPKGGLATPPPKGAP------TTPAATPPSPKGGLATPP 1167
Query: 145 CNGLPGSDSRRAPG-KGGGSKGSPGQRPPVPAA---AAAGAQARASCAAAKTQGRCCWEC 200
G P + + P KGG + SP P PAA + G A S A T
Sbjct: 1168 PKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPS 1227
Query: 201 LQNNLAVLPGELGA--LPHSATAEEKPARALP----AQDDRGASREREEGALAEP----A 250
+ LA P GA P + K A P A A+ +G LA P A
Sbjct: 1228 PKGGLAT-PSPKGAPTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGGLATPPHKGA 1286
Query: 251 PVPAVAHSPPATVEAATS----RASPPALLPGPAPRG 283
P PAV P ATS +PPA P P+P+G
Sbjct: 1287 PNPAVVTPPSPKGGPATSPPKGAPTPPAATP-PSPKG 1322
Score = 45.4 bits (106), Expect = 2e-04
Identities = 49/194 (25%), Positives = 68/194 (35%), Gaps = 12/194 (6%)
Query: 93 PAAAPSAGGAAPCSPRGARRGEPPQQQPRRRRREKE-PEEEPAGAAARAADA-ACNGLPG 150
P AP+ P SP+G PP++ P P+E PA A + A A +
Sbjct: 861 PKGAPTPSAVTPLSPKGVTL--PPKETPTPSVVNLPFPKEGPATPAPKQAPALSMTSSSP 918
Query: 151 SDSRRAPG-KGGGSKGSPGQRPPVPAAAAAGAQARASCAAAKTQGRCCWECLQNNLAVLP 209
+R P KG + SP P PAA + + + K W
Sbjct: 919 KKARATPAPKGIPASPSPKGAPTPPAATPPSPKGGPATPSPK------WAPTPPAATPPS 972
Query: 210 GELGALPHSATAEEKPARALPAQDDRGASREREEGALAEPAPVPAVAHSPPATVEAATSR 269
+ G S P A P G + +GA PA P PA
Sbjct: 973 PKGGPATPSPKGAPTPPAATPPSPKGGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGA 1032
Query: 270 ASPPALLPGPAPRG 283
++PPA P P+P+G
Sbjct: 1033 STPPAATP-PSPKG 1045
Score = 41.6 bits (96), Expect = 0.003
Identities = 71/315 (22%), Positives = 108/315 (34%), Gaps = 49/315 (15%)
Query: 90 REPPAAAPSAGGAAPCSPRGARRGEP--PQQQPRRRRREKEPEEEPAGAAARAADAACNG 147
+ P +AP G A P S +G+P P P + P++ ++ + A A
Sbjct: 1445 KAPATSAPKGGPATPSS-----KGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAP 1499
Query: 148 LPGSDSRRAPGKGGGSKGSPGQRPPVPAAAAAGAQARASCAAAKTQGRCCWECLQNNLAV 207
+ AP SP + P P++ A+ + KT +
Sbjct: 1500 MG------APTLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKKTPA-----------TL 1542
Query: 208 LPGELGALPHSATAEEKPARALPAQDDRGASREREEGALA--------EPAPVPAVAHSP 259
P E P K A+P + A+ +E + + AP P P
Sbjct: 1543 APKEALIPPAMTVPSPKKTPAIPTPKEAPATPSSKEASSPPAVTPSTYKGAPSPKELLIP 1602
Query: 260 PATVEAATSRA-SPPALLPG--------PAPRGDRPEL-LTPSSLHYSTLQQQQQRTREW 309
PA + A +PPA+ P PAP+G +TPSSL S +
Sbjct: 1603 PAVTSPSPKEAPTPPAVTPPSPEKGPATPAPKGTPTSPPVTPSSLKDSPTSPASVTCKMG 1662
Query: 310 VARHPQVPEARDQGPIRAWSVLPDNFLQLPLE---PGSTEPNSEPPDPCLSSHSLFPVVP 366
VP+A P + L P P T P + P SS + P+ P
Sbjct: 1663 AT----VPQASKGLPAKKGPTALKEVLVAPAPESTPIITAPTRKGPQTKKSSATSPPICP 1718
Query: 367 DESWESWAGNPSLTV 381
D S ++ + P TV
Sbjct: 1719 DPSAKNGSKGPLSTV 1733
Score = 39.7 bits (91), Expect = 0.011
Identities = 55/215 (25%), Positives = 70/215 (32%), Gaps = 43/215 (20%)
Query: 89 PREP-PAAAPSAGGAAPCSPRGARRGEPPQQQPRRRRREKEPEEEPAGAAARAADAACNG 147
P P P AP+ A P SP+G P+ P P P A + G
Sbjct: 931 PASPSPKGAPTPPAATPPSPKGGPATPSPKWAPT------PPAATPPSPKGGPATPSPKG 984
Query: 148 LPGSDSRRAPG-KGGGSKGSPGQRPPVPAAAAAGAQARASCAAAKTQGRCCWECLQNNLA 206
P + P KGG + SP P PA +
Sbjct: 985 APTPPAATPPSPKGGPATPSPKGAPTPPAVTPPSPK------------------------ 1020
Query: 207 VLPGELGALPHSATAEEKPARALPAQDDRGASREREEGALAEPA---PVPAVAHSPPATV 263
G A P A PA P+ A+ +GA PA P P + P+
Sbjct: 1021 ---GSPAATPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKGGPATPSLK 1077
Query: 264 EAAT-SRASPPALLPGPA---PRG-DRPELLTPSS 293
A T A+PP+ GPA P+G P TP S
Sbjct: 1078 GAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPS 1112
Score = 38.9 bits (89), Expect = 0.019
Identities = 116/478 (24%), Positives = 157/478 (32%), Gaps = 79/478 (16%)
Query: 92 PPAAAPSA--GGAAPCSPRGARRGEPPQQQPRRRRREKEPEEEPAGAAARAADAACNGLP 149
PPAA P + GG A SP+GA PP P P+ PA + + A P
Sbjct: 965 PPAATPPSPKGGPATPSPKGAPT--PPAATP------PSPKGGPATPSPKGAPTPPAVTP 1016
Query: 150 GSD--SRRAPGKGGGSKGSPGQRPPVPAAAAA------GAQARASCAAAKTQGRCCWECL 201
S S A G+ P PP P + A GA + +G L
Sbjct: 1017 PSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKGGPATPSL 1076
Query: 202 QNN----LAVLPGELG--ALPHSATAEEKPARALPAQDDRGASREREEGALAEPAPVPAV 255
+ A P G A P A PA A P G + +GA PA P
Sbjct: 1077 KGAPTPPAATPPSPKGGPATPSPKGAPMPPA-ATPPSPKGGLATPPHKGAPTTPAATPP- 1134
Query: 256 AHSPPATVEAATSRASP--PALLPGPAPRGDRPELLTPSSLHYSTLQQQQQRTREWVARH 313
SP + + +P PA P P+P+G L TP T + +
Sbjct: 1135 --SPKGGLATPPPKGAPTTPAATP-PSPKGG---LATPPPKGAPTTPAATPPSPKGGLAT 1188
Query: 314 PQVPEARDQGPIRAWSVLPDNFLQLPLEPGS-TEPNSEPPDP----CLSSHSLFPVVPDE 368
P P+ P A P L P G+ T P + PP P S P P
Sbjct: 1189 PS-PKGAPTTP-AATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAA 1246
Query: 369 SWESWAGNPSLTVFRSIRCQLSLQDLDDFVDQESDGSEESSSGPKDSPGASEEGLQVVLG 428
+ S G P + G P A+ L+ L
Sbjct: 1247 TPPSPKGGP---------------------------ATPPPKGAPTPPAATPPSLKGGLA 1279
Query: 429 TPDRGKLRNPAGGLSVSRKEGSPSRSPQGLRNRGDGHISQQVPAGANGL---AGHPLKP- 484
TP NPA S K G + P+G + P G+ G G P P
Sbjct: 1280 TPPHKGAPNPAVVTPPSPKGGPATSPPKGAPT--PPAATPPSPKGSPGTPPPKGAPTPPA 1337
Query: 485 LPWPVPKLRRSLRRSSLAGRAKLSSSDEEYLDEGLLKRSRRPPRSRKPSKAGTAPSPR 542
+ P PK +L ++ + + ++ + EG + P S K A T PSP+
Sbjct: 1338 VTPPSPKGTPTLPATTPSSKGGPTTPSSK---EGPTPPAATP--SHKGGPAMTPPSPK 1390
Score = 37.0 bits (84), Expect = 0.072
Identities = 56/281 (19%), Positives = 82/281 (29%), Gaps = 20/281 (7%)
Query: 89 PREPPAAAPSAGGAAPCSPRGARRGEPPQQQPRRRRREKEPEEEPAGAAARAADAACNGL 148
P PS G SP P P + P + A + G
Sbjct: 1287 PNPAVVTPPSPKGGPATSPPKGAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTPPSPKGT 1346
Query: 149 PGSDSRRAPGKGGGSKGSPGQRPPVPAAAAAGAQARASCAAAKTQGRCCWECLQNNLAVL 208
P + KGG + S + P PAA + A + +G +
Sbjct: 1347 PTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPPSPKRG-----------PAI 1395
Query: 209 PGELGALPHSATAEEKPARALPAQDDRGASREREEGALAEPAPVPAVAHSPPATVEAATS 268
P G A P +A R + +G L PA P PAT
Sbjct: 1396 PSPKGDPTSPAVIPLSPKKAPATPVTREGAATPSKGDLTPPAVTPVSLKKAPATSAPKGG 1455
Query: 269 RASPPALLPGPAPRGDRPELLTPSSLHYSTLQQQQQRTREWVARHPQVPEARDQGPIRAW 328
A+P + P P P + +Q T + P P + A
Sbjct: 1456 PATPSSKGDPTLPAVTPPSPKEPPA-------PKQVATSSSPKKAPATPAPMGAPTLPA- 1507
Query: 329 SVLPDNFLQLPLEPGSTEPNSEPPDPCLSSHSLFPVVPDES 369
V+P + ++P P S P LS + + P E+
Sbjct: 1508 -VIPSSPKEVPATPSSRRDPIAPTATLLSKKTPATLAPKEA 1547
>gi|110832843 TBP-associated factor 4 [Homo sapiens]
Length = 1085
Score = 53.1 bits (126), Expect = 1e-06
Identities = 59/203 (29%), Positives = 68/203 (33%), Gaps = 34/203 (16%)
Query: 82 GEEGLQRPREPPAAAPSAGGAAPCSPRGARRGEPPQQQPRRRRREKEPEEEPAGAAARAA 141
G +RP P AP A P P G+ P P PE PAG A A
Sbjct: 106 GPPSPRRPLVPAGPAPPAAKLRP-PPEGSAGSCAPV--PAAAAVAAGPEPAPAGPAKPAG 162
Query: 142 DAACNGLPGSDSRRAPGKGGGSKGSPGQRPPVPAAAAAGAQARASCAAAKTQGRCCWECL 201
AA +R PG G G PG P PA A + L
Sbjct: 163 PAALA------ARAGPGPGPGPGPGPGPGPGKPAGPGAA------------------QTL 198
Query: 202 QNNLAVLPGELGALPHSATAEEKPARALPAQDDRGASREREE----GALAEPAPVPAVAH 257
+ A+L A P + PA LP + GA A PAP A
Sbjct: 199 NGSAALLNSHHAAAPAVSLVNNGPAALLPLPKPAAPGTVIQTPPFVGAAAPPAPA---AP 255
Query: 258 SPPATVEAATSRASPPALLPGPA 280
SPPA A A+PP P PA
Sbjct: 256 SPPAAPAPAAPAAAPPPPPPAPA 278
Score = 44.7 bits (104), Expect = 3e-04
Identities = 63/204 (30%), Positives = 82/204 (40%), Gaps = 36/204 (17%)
Query: 92 PPA-AAPSAGGA-APCSPRGARRGEPPQQQPRRRRREKEPEEEPAGAAARA------ADA 143
PPA AAPS A AP +P A PP R P PAG A A A
Sbjct: 249 PPAPAAPSPPAAPAPAAPAAAPPPPPPAPATLAR-----PPGHPAGPPTAAPAVPPPAAA 303
Query: 144 ACNGLPGSDSRRAPGKGG--GSKGSPGQRPPVPAAA-AAGAQA-------RASCAAAKTQ 193
G G+ AP GG G G PG P AAA A G +A +A+ AA+T
Sbjct: 304 QNGGSAGAAPAPAPAAGGPAGVSGQPG--PGAAAAAPAPGVKAESPKRVVQAAPPAAQTL 361
Query: 194 GRCCWECLQNNLAVLPGELGALPHSATAEEKPARALPAQDDRGASREREEGALAEPAPVP 253
++ + P GALP S A PA P +GA+ GA+ +
Sbjct: 362 AASGPASTAASMVIGPTMQGALP-SPAAVPPPAPGTPTGLPKGAA-----GAVTQ----- 410
Query: 254 AVAHSPPATVEAATSRASPPALLP 277
+++ +P AT + +P L P
Sbjct: 411 SLSRTPTATTSGIRATLTPTVLAP 434
Score = 38.9 bits (89), Expect = 0.019
Identities = 63/230 (27%), Positives = 75/230 (32%), Gaps = 28/230 (12%)
Query: 93 PAAAPSAGGAAPCSPRGARRGEPPQQQPRRRRREKEPEEEPAGAAARAADAACNGLPGSD 152
P P+A G +P PP P PA AA AA P +
Sbjct: 227 PLPKPAAPGTVIQTPPFVGAAAPPAPAA------PSPPAAPAPAAPAAAPPPPPPAPATL 280
Query: 153 SRRAPGKGGGSKGSPGQRPPVPAAAAAGAQARASCAAAKTQGRCCWECLQNNLAVLPGEL 212
+R PG G + PP PAAA G A A+ A A G Q PG
Sbjct: 281 AR-PPGHPAGPPTAAPAVPP-PAAAQNGGSAGAAPAPAPAAGGPAGVSGQPG----PGAA 334
Query: 213 GALPHSATAEEKPARAL----PAQDDRGASRERE-----------EGALAEPAPVPAVAH 257
A P E P R + PA AS +GAL PA VP A
Sbjct: 335 AAAPAPGVKAESPKRVVQAAPPAAQTLAASGPASTAASMVIGPTMQGALPSPAAVPPPAP 394
Query: 258 SPPATVEAATSRASPPALLPGP-APRGDRPELLTPSSLHYSTLQQQQQRT 306
P + + A +L P A LTP+ L Q Q T
Sbjct: 395 GTPTGLPKGAAGAVTQSLSRTPTATTSGIRATLTPTVLAPRLPQPPQNPT 444
Score = 34.7 bits (78), Expect = 0.36
Identities = 66/235 (28%), Positives = 81/235 (34%), Gaps = 39/235 (16%)
Query: 85 GLQRPREPPAAAPSAG---GAAPCSPRGARRGEPPQQQPRRRRREKEPEEEPAGAAARAA 141
G +P P A A AG G P G G+P + AAA A
Sbjct: 156 GPAKPAGPAALAARAGPGPGPGPGPGPGPGPGKPAGPGAAQTLNGSAALLNSHHAAAPAV 215
Query: 142 DAACNG-----------LPGSDSRRAPGKGGGSKGSPG--QRPPVPAAAAAGAQARASCA 188
NG PG+ + P G + +P P PA AA A
Sbjct: 216 SLVNNGPAALLPLPKPAAPGTVIQTPPFVGAAAPPAPAAPSPPAAPAPAAPAAAPPPPPP 275
Query: 189 AAKTQGRCCWECLQNNLAVLPGELGALPHSATAEE------KPARALPAQDDRGASRERE 242
A T R + A P A+P A A+ PA A A G S +
Sbjct: 276 APATLARP-----PGHPAGPPTAAPAVPPPAAAQNGGSAGAAPAPAPAAGGPAGVSGQPG 330
Query: 243 EGALAEPAPVPAV-AHSPPATVEAA-----TSRASPPA-----LLPGPAPRGDRP 286
GA A AP P V A SP V+AA T AS PA ++ GP +G P
Sbjct: 331 PGAAAA-APAPGVKAESPKRVVQAAPPAAQTLAASGPASTAASMVIGPTMQGALP 384
>gi|157504499 ankyrin repeat domain 47 [Homo sapiens]
Length = 821
Score = 53.1 bits (126), Expect = 1e-06
Identities = 111/422 (26%), Positives = 148/422 (35%), Gaps = 87/422 (20%)
Query: 96 APSAGGAAPCSPRGARRGEP-PQQQPR------------------RRRREKE------PE 130
APS G P SPRG+ R P P P RR RE E PE
Sbjct: 150 APSPGRGVPRSPRGSGRSSPAPNLAPASPGPAQLQLVREQMAAALRRLRELEDQARTLPE 209
Query: 131 EEPAGAAARAADAACNGLPGSDSRRAPGKGGGSKGSPGQRPPVP------AAAAAGAQAR 184
+ A RA A L G R P G ++ P + + A + G +AR
Sbjct: 210 LQEQVRALRAEKARL--LAG---RAQPEPDGEAETRPDKLAQLRRLTERLATSERGGRAR 264
Query: 185 ASCAAAKTQGRCCWECLQNNLAVLPGELGALPHSATAEEKPARALPAQDDRGASREREEG 244
AS A G + L VL GE+G+L + E A A+P RE G
Sbjct: 265 ASPRADSPDGLAAGRS-EGALQVLDGEVGSLDGTPQTREVAAEAVP--------ETREAG 315
Query: 245 ALAEPAPVPAVAHSPPATVEAATSRASPPALLPGPAPRGDRPELLTPSSLH--------- 295
A A P A + P TVEA ALL PA ELL S H
Sbjct: 316 AQAVPETREAGVEAAPETVEA--DAWVTEALLGLPAAAERELELLRASLEHQRGVSELLR 373
Query: 296 --YSTLQQQQQRTREWVA-RHPQVPEARDQGPIRAWS-----VLPDNFLQLPLEPGSTEP 347
L++ ++ E A Q+ EA Q P WS ++ + P + P
Sbjct: 374 GRLRELEEAREAAEEAAAGARAQLREATTQTP---WSCAEKAAQTESPAEAPSLTQESSP 430
Query: 348 NSEPPDPCLSSHSLFPVVPDESWESWAGNPS--------LTVFRSIRCQLSLQDLDDF-V 398
S D ++ + + + + PS + V S +D D
Sbjct: 431 GSMDGDRAVAPAGILKSIMKKRDGTPGAQPSSGPKSLQFVGVLNGEYESSSSEDASDSDG 490
Query: 399 DQESDGSE---ESSSGPKDSPGASEEGLQVVLGTPDRGKLRNPAGGLSVSRKEGSPSRSP 455
D E+ G+E SS DS G S+ G G P G +R+P E P +
Sbjct: 491 DSENGGAEPPGSSSGSGDDSGGGSDSGTP---GPPSGGDIRDPE-----PEAEAEPQQVA 542
Query: 456 QG 457
QG
Sbjct: 543 QG 544
>gi|38176283 ankyrin repeat and SOCS box-containing protein 7
isoform 2 [Homo sapiens]
Length = 318
Score = 52.8 bits (125), Expect = 1e-06
Identities = 28/84 (33%), Positives = 48/84 (57%), Gaps = 4/84 (4%)
Query: 626 KDFLTGYTALHWIAKHGDLRALQDLVSGAKKAGIVLDVNVRSSCGYTPLHLAAIHGHQGV 685
KD + G+TALH+ A HG R + ++ ++ I+ N +S+ G+TPLH+AA +G
Sbjct: 76 KDLIGGFTALHYAAMHGRARIARLMLESEYRSDII---NAKSNDGWTPLHVAAHYGRDSF 132
Query: 686 IKLLVQRLASRVNVRDSSGKKPWQ 709
++LL++ + V+ G P Q
Sbjct: 133 VRLLLE-FKAEVDPLSDKGTTPLQ 155
>gi|24497554 homeobox A13 [Homo sapiens]
Length = 388
Score = 52.8 bits (125), Expect = 1e-06
Identities = 70/284 (24%), Positives = 100/284 (35%), Gaps = 45/284 (15%)
Query: 95 AAPSAGGAAPCSPRGARRGEPPQQQPRRRRREKEPEEEPAGAAARAADAACNGLPGSDSR 154
AA +A AA + GA G P A AAA AA+ C L +
Sbjct: 38 AAAAAAAAAAAAAAGAGGGGFPHPAAAAAGGNFSVAAAAAAAAAAAANQ-CRNLMAHPAP 96
Query: 155 RAPGKGGGSKGSPGQRPPVPAAAAAGAQARASCAAAKTQGRCCWECLQNNLAVLPGELGA 214
APG +PG+ PP AAAAA A A A+ AAA + PG G
Sbjct: 97 LAPGAASAYSSAPGEAPPSAAAAAAAAAAAAAAAAAASSSGG------------PGPAGP 144
Query: 215 LPHSATAEEKPARALPAQDDRGASREREEGALAEPAPVPAVAHSPPATV----EAATSRA 270
A + P A+ + G A P + P A + A S A
Sbjct: 145 AGAEAAKQCSPC---------SAAAQSSSGPAALPYGYFGSGYYPCARMGPHPNAIKSCA 195
Query: 271 SPPALLPGPAPRGDRPELLTPSSLHYSTLQQQQQRTREWVARHPQVPEARDQGPIRAWSV 330
P + A + P++ +S+ R +E+ H + GP
Sbjct: 196 QPASAAAAAAFADKYMDTAGPAAEEFSS------RAKEFAFYH----QGYAAGPYHHHQP 245
Query: 331 LPDNFLQLPLEPGSTEPNSEPPDPCLSSHSLFPVVPDESWESWA 374
+P +L +P+ PG P +P +P ES++ WA
Sbjct: 246 MP-GYLDMPVVPGLGGPGESRHEPL--------GLPMESYQPWA 280
Score = 33.9 bits (76), Expect = 0.61
Identities = 32/99 (32%), Positives = 36/99 (36%), Gaps = 10/99 (10%)
Query: 94 AAAPSAGGAAPCSPRGARRGEPPQQQPRRRRREKEPEEEPAGAAARAADAACNGLPGSDS 153
AAA +A AA R P P E P AAA AA AA +
Sbjct: 74 AAAAAAAAAAANQCRNLMAHPAPLAPGAASAYSSAPGEAPPSAAAAAAAAA--------A 125
Query: 154 RRAPGKGGGSKGSPGQRPPVPAAAAAGAQARASCAAAKT 192
A S G PG P PA A A Q AAA++
Sbjct: 126 AAAAAAAASSSGGPG--PAGPAGAEAAKQCSPCSAAAQS 162
>gi|30089994 ankyrin repeat and SOCS box-containing protein 7
isoform 1 [Homo sapiens]
Length = 274
Score = 52.8 bits (125), Expect = 1e-06
Identities = 28/84 (33%), Positives = 48/84 (57%), Gaps = 4/84 (4%)
Query: 626 KDFLTGYTALHWIAKHGDLRALQDLVSGAKKAGIVLDVNVRSSCGYTPLHLAAIHGHQGV 685
KD + G+TALH+ A HG R + ++ ++ I+ N +S+ G+TPLH+AA +G
Sbjct: 76 KDLIGGFTALHYAAMHGRARIARLMLESEYRSDII---NAKSNDGWTPLHVAAHYGRDSF 132
Query: 686 IKLLVQRLASRVNVRDSSGKKPWQ 709
++LL++ + V+ G P Q
Sbjct: 133 VRLLLE-FKAEVDPLSDKGTTPLQ 155
>gi|30795231 brain abundant, membrane attached signal protein 1
[Homo sapiens]
Length = 227
Score = 52.4 bits (124), Expect = 2e-06
Identities = 60/219 (27%), Positives = 83/219 (37%), Gaps = 46/219 (21%)
Query: 83 EEGLQRPREPPAAAPSAGGAAPCSPRGARRG-EPPQQQPRRRRREKEPEEEPAGAAARAA 141
EEG + EP AAA P A+ G E P Q + EKE E++ A A A
Sbjct: 33 EEGTPKESEPQAAA---------EPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAP 83
Query: 142 DAACNGLPGS------------DSRRAPGKGGGSKGSPGQRPPVPAAAAAGAQARASCAA 189
A G+ + APG G G+ P AAAA A++ A A
Sbjct: 84 KAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAG-----GEAPKAAEAAAAPAESAAPAAG 138
Query: 190 ---AKTQGRCCWECLQNNLAVLPGELGALPHSATAEEKPARALPAQDDRGASREREEGAL 246
+K +G P + A P + A+E + PA D + S E +
Sbjct: 139 EEPSKEEGE-------------PKKTEA-PAAPAAQETKSDGAPASDSKPGSSEAAPSSK 184
Query: 247 AEPAPVPAVAHSPPATVEAATSRASPPALLPGPAPRGDR 285
PA A + +P A AA+ A P + PA D+
Sbjct: 185 ETPAATEAPSSTPKAQGPAAS--AEEPKPVEAPAANSDQ 221
Score = 37.4 bits (85), Expect = 0.055
Identities = 25/73 (34%), Positives = 32/73 (43%), Gaps = 6/73 (8%)
Query: 221 AEEKPARALPAQDDRGASREREEGALAEPAPVPAVAHSPPATVEAATSRASPP------A 274
AE K + P QD G + E+E A A A P T AA ++A PP
Sbjct: 49 AEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQ 108
Query: 275 LLPGPAPRGDRPE 287
PGPA G+ P+
Sbjct: 109 AAPGPAAGGEAPK 121
Score = 31.2 bits (69), Expect = 3.9
Identities = 32/137 (23%), Positives = 49/137 (35%), Gaps = 16/137 (11%)
Query: 154 RRAPGKGGGSKGSPGQRPPVPAAAAAGAQARASCAAAKTQGRCCWECLQNNLAVLPGELG 213
++A G +G+P + P AA A A+ +G+ E
Sbjct: 24 KKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKA-------------EEKE 70
Query: 214 ALPHSATAEEKPARALPAQDDRGASREREEGALAEP---APVPAVAHSPPATVEAATSRA 270
+A A+E+ +A P + + A + E E AP PA P EAA + A
Sbjct: 71 GEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPA 130
Query: 271 SPPALLPGPAPRGDRPE 287
A G P + E
Sbjct: 131 ESAAPAAGEEPSKEEGE 147
>gi|148596917 fibronectin type III and ankyrin repeat domains 1
[Homo sapiens]
Length = 345
Score = 52.0 bits (123), Expect = 2e-06
Identities = 37/96 (38%), Positives = 53/96 (55%), Gaps = 7/96 (7%)
Query: 629 LTGYTALHWIAKHGDLRALQDLVSGAKKAGIVLDVNVRSSCGYTPL-HLAAIHGHQGVIK 687
L G TALHW A G ++ ++ K G +DV V + G+TPL ++A+ G+Q V
Sbjct: 208 LGGCTALHWAADGGHCSVIEWMI----KDGCEVDV-VDTGSGWTPLMRVSAVSGNQRVAS 262
Query: 688 LLVQRLASRVNVRDSSGKKPWQYLTSNTSGEIWQLL 723
LL+ A+ VNV+D +GK P N E+ QLL
Sbjct: 263 LLIDAGAN-VNVKDRNGKTPLMVAVLNNHEELVQLL 297
Score = 33.9 bits (76), Expect = 0.61
Identities = 26/74 (35%), Positives = 36/74 (48%), Gaps = 7/74 (9%)
Query: 631 GYTALHWIAKHGDLRALQDLVSGAKKAGIVLDVNVRSSCGYTPLHLAAIHGHQGVIKLLV 690
G+TAL A+ G R ++ LVS DVN+++ G L LA GH V+K L
Sbjct: 144 GFTALMVAAQKGYTRLVKILVSNGT------DVNLKNGSGKDSLMLACYAGHLDVVKYL- 196
Query: 691 QRLASRVNVRDSSG 704
+R + RD G
Sbjct: 197 RRHGASWQARDLGG 210
Score = 30.4 bits (67), Expect = 6.7
Identities = 20/58 (34%), Positives = 35/58 (60%), Gaps = 2/58 (3%)
Query: 648 QDLVSGAKKAGIVLDVNVRSSCGYTPLHLAAIHGHQGVIKLLVQRLASRVNVRDSSGK 705
+DL+ + G V V+V + G+T L +AA G+ ++K+LV + VN+++ SGK
Sbjct: 123 EDLLVRILQGGRV-KVDVPNKFGFTALMVAAQKGYTRLVKILVSN-GTDVNLKNGSGK 178
>gi|239508698 PREDICTED: similar to mucin [Homo sapiens]
Length = 265
Score = 50.8 bits (120), Expect = 5e-06
Identities = 65/243 (26%), Positives = 84/243 (34%), Gaps = 57/243 (23%)
Query: 88 RPREPPAAAPSAGGAAPCSPRGARRGE---PPQQQPRRRRREKEPEEEPAGAAARAAD-- 142
RP++ P P+ G G RRG P Q + RE+E PA RA D
Sbjct: 34 RPQQQPQCQPAGG-------TGQRRGSGSSPSADQQGAQDREEEAAAAPAADQQRAQDRE 86
Query: 143 --AACNGLPGSDSRRA-----------PGKGGGSKGSPGQRPPVPAAAAAGAQARASCAA 189
AA P S R P G G + G P +A GAQ R AA
Sbjct: 87 EEAAAAPAPTSSGHRTEKRKPQQPQCRPAGGTGQRRGSGSSP---SADQQGAQDREEEAA 143
Query: 190 AKTQGRCCWECLQNNLAVLPGELGALPHSATAEEKPARALPAQDDRGASREREEGALAEP 249
A + P + P + T + + +R+ P+ D +GA ++REE A A P
Sbjct: 144 AAPAPTSRGHRTEKR---KPQQPQRRPAAGTGQRRGSRSSPSADQQGA-QDREEEAAAAP 199
Query: 250 APV-----------------PAVA--------HSPPATVEAATSRASPPALLPGPAPRGD 284
P PA SP A + A R A P P G
Sbjct: 200 VPTSRGHRTEKRKRQQPQCRPAAGTGQRRGSRSSPSADQQRAQDREEEAAAAPAPTSSGH 259
Query: 285 RPE 287
R E
Sbjct: 260 RTE 262
>gi|78042577 MAP7 domain containing 1 [Homo sapiens]
Length = 841
Score = 50.8 bits (120), Expect = 5e-06
Identities = 66/257 (25%), Positives = 96/257 (37%), Gaps = 32/257 (12%)
Query: 89 PREPPAAAPSAGGAAPCSPRGARR-----GEP----------PQQQPRRRRREKEPEEEP 133
P P + S AP RG RR G P P Q+ ++ +E+E E+E
Sbjct: 369 PLTPCSVTRSVHRCAPAGERGERRKPNAGGSPAPVRRRPEASPVQKKEKKDKERENEKEK 428
Query: 134 AGAAARAADAACNGLPGSDSRRAPGKGGGSKGSPGQRPPVPAAAAAGAQARASCAAAKTQ 193
+ A + LP S R S+ SP + P++ + AS +
Sbjct: 429 SALARERSLKKRQSLPASPRARLSASTA-SELSPKSKAR-PSSPSTSWHRPASPCPSPGP 486
Query: 194 GRCCWECLQNNLAVLPGELGALPHSATAEEKPARALP---AQDDRGASREREEGALAEPA 250
G + G + A+E P+ A P +Q R AS E+E A A PA
Sbjct: 487 GHTLPPKPPSPRGTTASPKGRVRRKEEAKESPSAAGPEDKSQSKRRASNEKESAAPASPA 546
Query: 251 PVPAVAHSPPATVEAATSRASPPALLPGPA-----PRGDRPELLTPSSLHYSTLQQQQQR 305
P PA P+ A + PPA P A P P +TPS T +++
Sbjct: 547 PSPA-----PSPTPAPPQKEQPPAETPTDAAVLTSPPAPAPP-VTPSKPMAGT-TDREEA 599
Query: 306 TREWVARHPQVPEARDQ 322
TR + Q E R++
Sbjct: 600 TRLLAEKRRQAREQRER 616
Score = 33.5 bits (75), Expect = 0.79
Identities = 26/110 (23%), Positives = 45/110 (40%), Gaps = 3/110 (2%)
Query: 216 PHSATAEEKPARALPAQDDRGASRE---REEGALAEPAPVPAVAHSPPATVEAATSRASP 272
P SA + P PA + +S++ E + P PA + EA + +P
Sbjct: 39 PMSALVPDTPPDTPPAMKNATSSKQLPLEPESPSGQVGPRPAPPQEESPSSEAKSRGPTP 98
Query: 273 PALLPGPAPRGDRPELLTPSSLHYSTLQQQQQRTREWVARHPQVPEARDQ 322
PA+ P A R +P+++ S +Q ++ RH E R++
Sbjct: 99 PAMGPRDARPPRRSSQPSPTAVPASDSPPTKQEVKKAGERHKLAKERREE 148
>gi|48762934 alpha 2 type I collagen [Homo sapiens]
Length = 1366
Score = 50.4 bits (119), Expect = 6e-06
Identities = 68/248 (27%), Positives = 84/248 (33%), Gaps = 35/248 (14%)
Query: 65 PDGTKYVVLKRRYRDLLGEEGLQRP------REPPAAAPSAGGAAPCSPRGARRGEPPQQ 118
P G V K R L GE GL P R PP + +AG P RG P
Sbjct: 560 PSGPAGEVGKPGERGLHGEFGLPGPAGPRGERGPPGESGAAGPTGPIGSRG------PSG 613
Query: 119 QPRRRRREKEPEEEPAGAAARAADAACNGLPGSDSRRAPGKGGGSKGSPGQRPPV----- 173
P + EP GA A + +GLPG G G KG PG R +
Sbjct: 614 PPGPDGNKGEPGV--VGAVGTAGPSGPSGLPGERGAAGIPGGKGEKGEPGLRGEIGNPGR 671
Query: 174 ----PAAAAAGAQARASCAAAKTQGRCCWECLQNNLAVLPGELG----ALPHSATAEEKP 225
A A GA A + + PGE G A P+
Sbjct: 672 DGARGAPGAVGAPGPAGATGDRGEAGAAGPAGPAGPRGSPGERGEVGPAGPNGFAGPAGA 731
Query: 226 ARALPAQDDRGASRER-EEGALAEPAPV----PAVAHSPPATVEAATSRASPPAL--LPG 278
A A+ +RGA + E G + PV PA + PP + PP + PG
Sbjct: 732 AGQPGAKGERGAKGPKGENGVVGPTGPVGAAGPAGPNGPPGPA-GSRGDGGPPGMTGFPG 790
Query: 279 PAPRGDRP 286
A R P
Sbjct: 791 AAGRTGPP 798
Score = 48.1 bits (113), Expect = 3e-05
Identities = 56/206 (27%), Positives = 69/206 (33%), Gaps = 33/206 (16%)
Query: 82 GEEGLQRPREPPAAAPSAGGAAPCSPRGARRGEPPQQQPRRRRREKEPEEEPAGAAARAA 141
G GL PR PP AA + G P G GEP Q P R PAG +A
Sbjct: 91 GPMGLMGPRGPPGAAGAPGPQGFQGPAG-EPGEPGQTGPAGARG-------PAGPPGKAG 142
Query: 142 DAACNGLPGSDSRRAPGKGGGSKGSPGQRPPVPAAAAAGAQARASCAAAKTQGRCCWECL 201
+ G PG R G++G PG P +P G + K
Sbjct: 143 EDGHPGKPGRPGERGVVGPQGARGFPG-TPGLP--GFKGIRGHNGLDGLKG--------- 190
Query: 202 QNNLAVLPGELGALPHSATAEEKPARALPAQDDRGASREREEGALAEPAPVPAVAHS--- 258
Q + GE GA + T + AR LP E G + P P A
Sbjct: 191 QPGAPGVKGEPGAPGENGTPGQTGARGLPG----------ERGRVGAPGPAGARGSDGSV 240
Query: 259 PPATVEAATSRASPPALLPGPAPRGD 284
P A PP P P+G+
Sbjct: 241 GPVGPAGPIGSAGPPGFPGAPGPKGE 266
Score = 39.7 bits (91), Expect = 0.011
Identities = 53/205 (25%), Positives = 66/205 (32%), Gaps = 21/205 (10%)
Query: 82 GEEGLQRPREPPAAAPSAGGAAPCSPRGARRGEPPQQQPRRRRREKEPEEEPAGAAARAA 141
G G P AG A P P G R G P ++ E PAG A
Sbjct: 679 GAVGAPGPAGATGDRGEAGAAGPAGPAGPR-GSPGERG----------EVGPAGPNGFAG 727
Query: 142 DAACNGLPGSDSRRAPGKGGGSKGSPGQRPPVPAAAAAGAQARASCAAAKTQGRCCWECL 201
A G PG+ R G G G PV AA AG A ++ G
Sbjct: 728 PAGAAGQPGAKGERGAKGPKGENGVVGPTGPVGAAGPAGPNGPPGPAGSRGDGG------ 781
Query: 202 QNNLAVLPGELGAL--PHSATAEEKPARALPAQDDRGASREREEGALAEPAPVPAVAHSP 259
+ PG G P + P PA + ++G + V AV P
Sbjct: 782 PPGMTGFPGAAGRTGPPGPSGISGPPGPPGPAGKEGLRGPRGDQGPVGRTGEVGAVG-PP 840
Query: 260 PATVEAATSRASPPALLPG-PAPRG 283
E S + A PG P P+G
Sbjct: 841 GFAGEKGPSGEAGTAGPPGTPGPQG 865
Score = 37.4 bits (85), Expect = 0.055
Identities = 29/105 (27%), Positives = 35/105 (33%), Gaps = 15/105 (14%)
Query: 82 GEEGLQRPREPPAAAPSAGGAAPCSPRGAR--RGEPPQQQPRRRRREKEPEEEPAGAAAR 139
G G P P A + G P P+G R +GEP ++ PR G
Sbjct: 976 GNRGETGPSGPVGPAGAVGPRGPSGPQGIRGDKGEPGEKGPR-------------GLPGL 1022
Query: 140 AADAACNGLPGSDSRRAPGKGGGSKGSPGQRPPVPAAAAAGAQAR 184
GLPG GS G G R P + AG R
Sbjct: 1023 KGHNGLQGLPGIAGHHGDQGAPGSVGPAGPRGPAGPSGPAGKDGR 1067
Score = 35.0 bits (79), Expect = 0.27
Identities = 29/93 (31%), Positives = 35/93 (37%), Gaps = 9/93 (9%)
Query: 78 RDLLGEEGLQRPREPPAAAPSAGGAAPCSPRG--ARRGEPPQQQPRRRRREKEPEEEPAG 135
R L G +G PP + ++G A P G R GEP PR G
Sbjct: 405 RGLPGADGRAGVMGPPGSRGASGPAGVRGPNGDAGRPGEPGLMGPRGLPGSP-------G 457
Query: 136 AAARAADAACNGLPGSDSRRAPGKGGGSKGSPG 168
A GLPG D R P G++G PG
Sbjct: 458 NIGPAGKEGPVGLPGIDGRPGPIGPAGARGEPG 490
Score = 33.9 bits (76), Expect = 0.61
Identities = 70/235 (29%), Positives = 81/235 (34%), Gaps = 60/235 (25%)
Query: 82 GEEGLQRPREPPAAAPSAGGAAPCSPRGARRGEPPQQQPRRRRREKEPEEEPAGAAARAA 141
G G P+ A +AG A P PRG G P P P P A
Sbjct: 256 GFPGAPGPKGEIGAVGNAGPAGPAGPRG-EVGLPGLSGP------VGPPGNPGANGLTGA 308
Query: 142 DAACNGLPGSDSRRAPGKGGGSKGSPGQRPPVPAAAAAGAQARASCAAAKTQGRCCWECL 201
A GLPG APG G +G PG PV AA A GA+
Sbjct: 309 KGAA-GLPGVAG--APGL-PGPRGIPG---PVGAAGATGAR------------------- 342
Query: 202 QNNLAVLPGELGALPHSATAEEKPARALPAQDDRGASRER-------EEGALAEPAPVPA 254
L PG G+ S E P A P Q G S E E G+ P P P
Sbjct: 343 --GLVGEPGPAGSKGESGNKGE-PGSAGP-QGPPGPSGEEGKRGPNGEAGSAGPPGP-PG 397
Query: 255 VAHSPPAT-VEAATSR-----------ASPPALLPGP---APRGDRPELLTPSSL 294
+ SP + + A R AS PA + GP A R P L+ P L
Sbjct: 398 LRGSPGSRGLPGADGRAGVMGPPGSRGASGPAGVRGPNGDAGRPGEPGLMGPRGL 452
Score = 33.1 bits (74), Expect = 1.0
Identities = 30/125 (24%), Positives = 38/125 (30%), Gaps = 27/125 (21%)
Query: 82 GEEGLQRPREPPAAAPSAGGAAPCSPRGAR--------------------------RGEP 115
GE G+ P P AA AG P P G+R G P
Sbjct: 748 GENGVVGPTGPVGAAGPAGPNGPPGPAGSRGDGGPPGMTGFPGAAGRTGPPGPSGISGPP 807
Query: 116 PQQQPRRRRREKEPEEEPAGAAARAADAACNGLPGSDSRRAPGKGGGSKGSPGQRPPVPA 175
P + + P + G R + G PG + P G+ G PG P
Sbjct: 808 GPPGPAGKEGLRGPRGDQ-GPVGRTGEVGAVGPPGFAGEKGPSGEAGTAGPPGTPGPQGL 866
Query: 176 AAAAG 180
A G
Sbjct: 867 LGAPG 871
Score = 32.7 bits (73), Expect = 1.4
Identities = 24/91 (26%), Positives = 33/91 (36%), Gaps = 5/91 (5%)
Query: 78 RDLLGEEGLQRPREPPAAAPSAGGAAPCSPRGARRGEPPQQQPRRRRREKEPEEEPAGAA 137
R L+GE G + G A P P G P ++ +R + P G
Sbjct: 342 RGLVGEPGPAGSKGESGNKGEPGSAGPQGPPG-----PSGEEGKRGPNGEAGSAGPPGPP 396
Query: 138 ARAADAACNGLPGSDSRRAPGKGGGSKGSPG 168
GLPG+D R GS+G+ G
Sbjct: 397 GLRGSPGSRGLPGADGRAGVMGPPGSRGASG 427
Score = 32.0 bits (71), Expect = 2.3
Identities = 32/109 (29%), Positives = 40/109 (36%), Gaps = 24/109 (22%)
Query: 80 LLGEEGLQRPREPPAAAPSAGGAAP---CSPRGARRGEPPQQQPRRRRREKEPEEEPAGA 136
+LG G + R P A + G P P GAR P G
Sbjct: 872 ILGLPGSRGERGLPGVAGAVGEPGPLGIAGPPGARGPPGAVGSP--------------GV 917
Query: 137 AARAADAACNGLPGSDSRRAPGKGG-----GSKGSPGQRPPVPAAAAAG 180
+A +G PG+D PG+ G G +G PG PV AA A G
Sbjct: 918 NGAPGEAGRDGNPGNDG--PPGRDGQPGHKGERGYPGNIGPVGAAGAPG 964
Score = 31.6 bits (70), Expect = 3.0
Identities = 27/94 (28%), Positives = 34/94 (36%), Gaps = 7/94 (7%)
Query: 82 GEEGLQRPREPPAAAPSAGGAAPCSPRGARR--GEPPQQQPRRRRREK-----EPEEEPA 134
GE GL PR P + + G A P G G P P R E + P
Sbjct: 442 GEPGLMGPRGLPGSPGNIGPAGKEGPVGLPGIDGRPGPIGPAGARGEPGNIGFPGPKGPT 501
Query: 135 GAAARAADAACNGLPGSDSRRAPGKGGGSKGSPG 168
G + D GL G+ P G++G PG
Sbjct: 502 GDPGKNGDKGHAGLAGARGAPGPDGNNGAQGPPG 535
Score = 31.2 bits (69), Expect = 3.9
Identities = 55/234 (23%), Positives = 71/234 (30%), Gaps = 33/234 (14%)
Query: 82 GEEGLQRPREPPAAAPS---------AGGAAPCSPRGARRGEPPQQQPRRRRRE------ 126
GE G P+ PP + AG A P P G R + P R
Sbjct: 361 GEPGSAGPQGPPGPSGEEGKRGPNGEAGSAGPPGPPGLRGSPGSRGLPGADGRAGVMGPP 420
Query: 127 -KEPEEEPAGAAARAADAACNGLPGSDSRRAPGKGGGSKGSPGQRPPVPAAAAAGAQARA 185
PAG DA G PG R G+ G G+ PV G
Sbjct: 421 GSRGASGPAGVRGPNGDAGRPGEPGLMGPRGLPGSPGNIGPAGKEGPVGLPGIDGRPGPI 480
Query: 186 SCAAAKTQGRCCWECLQNNLAVLPGELGALPHSATAEEKPARALPAQDDRGASR------ 239
A A+ + PG+ G H+ A AR P D ++
Sbjct: 481 GPAGARGEPGNIGFPGPKGPTGDPGKNGDKGHAGLA---GARGAPGPDGNNGAQGPPGPQ 537
Query: 240 --EREEGALAEPAPVPAVAHSPPATVEAATSRASPPAL-----LPGPA-PRGDR 285
+ +G P P P+ + L LPGPA PRG+R
Sbjct: 538 GVQGGKGEQGPPGPPGFQGLPGPSGPAGEVGKPGERGLHGEFGLPGPAGPRGER 591
>gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]
Length = 904
Score = 50.1 bits (118), Expect = 8e-06
Identities = 111/515 (21%), Positives = 164/515 (31%), Gaps = 58/515 (11%)
Query: 88 RPREPPAAAPSAGGAAPCSPRGARRGEPPQQQPRRRRREKEPEEEPAGAAARAADAACNG 147
R R PP P + P R RR P PRRR R P P N
Sbjct: 366 RSRSPPKKPPKRTSSPP---RKTRRLSPSASPPRRRHRPSPPATPPPKTRHSPTPQQSNR 422
Query: 148 LPGSDSRRAPGKGGGS----KGSPGQRPPVPAAAAAGAQARAS--------CAAAKTQGR 195
S +PG+ G KG+ + P PA + S AA Q R
Sbjct: 423 TRKSRVSVSPGRTSGKVTKHKGTEKRESPSPAPKPRKVELSESEEDKGGKMAAADSVQQR 482
Query: 196 CCWECLQNNLAVLPGELGALPHSATAEEKPARALPAQDDRGASREREEGALAEPAPVPAV 255
+ + G S++ +E+P R+ + G R A P+P
Sbjct: 483 RQYRRQNQQSSSDSGS-----SSSSEDERPKRSHVKNGEVGRRRRHSPSRSASPSPRKRQ 537
Query: 256 AHSPPATVEAATSRASPPALLPGPAPRGDRPELLTPSSLHYSTLQQQQQRTREWVARHPQ 315
+ P + P P+P TP+ R R R
Sbjct: 538 KETSPRGRRRRSPSPPPTRRRRSPSPAPPPRRRRTPTPPPRRRTPSPPPRRRSPSPRRYS 597
Query: 316 VPEARDQGPIRAWSVLPDNFLQLPLEPGSTEPNSEPPDPCLSSHSLFPVVPDESWESWAG 375
P R P S P P P + PP SHS P S +
Sbjct: 598 PPIQRRYSP----SPPPKRRTASPPPPPKRRASPSPPPKRRVSHSP-PPKQRSSPVTKRR 652
Query: 376 NPSL--------TVFRSIRCQLSLQDLDDFVDQESDGSEESSSGP-------------KD 414
+PSL + RS R S Q + ++SS P +
Sbjct: 653 SPSLSSKHRKGSSPSRSTREARSPQPNKRHSPSPRPRAPQTSSSPPPVRRGASSSPQRRQ 712
Query: 415 SPGASEEGLQVVLGTPDRGKLRNPAGGLSVSRKEGSPSRSPQGLRNRG-------DGHIS 467
SP S ++ V TP+ K++ A S + S SRS G +
Sbjct: 713 SPSPSTRPIRRVSRTPEPKKIKKAASPSPQSVRRVSSSRSVSGSPEPAAKKPPAPPSPVQ 772
Query: 468 QQVPAGANGLAGHPLKPL--PWPVPKLRRSLRRSSLAGRAKLSSSDEEYLDEGLLKRSRR 525
Q P+ N P+K P P P R+ + G+ K D+++ + K+ ++
Sbjct: 773 SQSPS-TNWSPAVPVKKAKSPTPSPSPPRNSDQEG-GGKKKKKKKDKKHKKDKKHKKHKK 830
Query: 526 PPRSRK-PSKAGTAPSPRVDAGLSLKLAEVKAVVA 559
+ + + A A +P A + LA+ + V A
Sbjct: 831 HKKEKAVAAAAAAAVTPAAIAAATTTLAQEEPVAA 865
Score = 43.1 bits (100), Expect = 0.001
Identities = 76/354 (21%), Positives = 128/354 (36%), Gaps = 46/354 (12%)
Query: 38 DASPSQHQHRRELFKGFVNSVAAVRQDPDGTKYVVLKRRYRDLLGEEGLQRPREPP-AAA 96
D+ + Q+RR+ + +S ++ + + K +K GE G +R P +A+
Sbjct: 477 DSVQQRRQYRRQNQQSSSDSGSSSSSEDERPKRSHVKN------GEVGRRRRHSPSRSAS 530
Query: 97 PSAGGAAP-CSPRGARRGEPPQQQPRRRRREKEPEEEPAGAAARAADAACNGLPGSDSRR 155
PS SPRG RR P P RRRR P P P RR
Sbjct: 531 PSPRKRQKETSPRGRRR-RSPSPPPTRRRRSPSPAPPPRRRRT----------PTPPPRR 579
Query: 156 APGKGGGSKGSPGQR---PPVPAAAAAGAQARASCAAAKTQGRCCWECLQNNLAVLPGEL 212
+ SP R PP+ + + A+ + + P
Sbjct: 580 RTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKRRTASPPPPPK-------RRASPSPPPK 632
Query: 213 GALPHSATAEEKPARALPAQDDRGASREREEGALAEP-----APVPAVAHSPPATVEAAT 267
+ HS +++ + + +S+ R+ + + +P P HSP A
Sbjct: 633 RRVSHSPPPKQRSSPVTKRRSPSLSSKHRKGSSPSRSTREARSPQPNKRHSPSPRPRAPQ 692
Query: 268 SRASPPALLPGPAPRGDRPELLTPSSLHYSTLQQQQQRTREWVARHPQVPEARDQGPIRA 327
+ +SPP + G + R + +PS+ + + + + A P R R+
Sbjct: 693 TSSSPPPVRRGASSSPQRRQSPSPSTRPIRRVSRTPEPKKIKKAASPSPQSVRRVSSSRS 752
Query: 328 WSVLPDNFLQLPLEPGSTEPNSEPPDPCLS---SHSLFPVVPDESWESWAGNPS 378
S P EP + +P + PP P S S + P VP + +S +PS
Sbjct: 753 VSGSP--------EPAAKKPPA-PPSPVQSQSPSTNWSPAVPVKKAKSPTPSPS 797
>gi|110556636 tankyrase 1-binding protein 1 [Homo sapiens]
Length = 1729
Score = 49.7 bits (117), Expect = 1e-05
Identities = 101/398 (25%), Positives = 135/398 (33%), Gaps = 72/398 (18%)
Query: 114 EPPQQQPRRRRRE--KEPEEE--PAGAAARA--ADAACNGLPGSDSRR------APGKGG 161
E P + P R E K PEE P+ A A AA + LP S+ AP
Sbjct: 223 EGPVKSPAECREEHSKTPEERSLPSDLAFNGDLAKAASSELPADISKPWIPSSPAPSSEN 282
Query: 162 GSKGSPGQRPPVPAAAAAGAQARASCAAAKTQGRCCWECLQNNLAVLPGELGALPHSATA 221
G SPG +PA A+ C + L+ A P A P A
Sbjct: 283 GGPASPG----LPAEASGSGPGSPHLHPPDKSSPCHSQLLE---AQTPEASQASPCPAVT 335
Query: 222 EEKPARALPAQDDRGASREREEGALAEPAPVPAVAHSPPATVEAATSRASPPALLPGPA- 280
P+ ALP D G+ G AE AP SPP V S PPA P P
Sbjct: 336 PSAPSAALP---DEGSRHTPSPGLPAEGAPEAPRPSSPPPEVLEPHSLDQPPATSPRPLI 392
Query: 281 ------------PRGDRPELLTPSSLHYSTLQQQQQRTREWVARHPQVPEARDQGPIRAW 328
P G E + L ++L Q+R E V + P + + G + A
Sbjct: 393 EVGELLDLTRTFPSGGEEEAKGDAHLRPTSL--VQRRFSEGVLQSPSQDQEKLGGSLAA- 449
Query: 329 SVLPDNFLQLPLEPGSTEPNSEPPDPCLSSHSLFPVVPDESWESWAGNPSLTVFRSIRCQ 388
LP GS P + S + + W L V+R
Sbjct: 450 ---------LPQGQGSQLALDRP----FGAESNWSLSQSFEWTFPTRPSGLGVWR----- 491
Query: 389 LSLQDLDDFVDQESDGSEESSSGPKDSPGASEEGLQVVLGTPDRGKLRNPAGGLSVSRKE 448
L E+ + E++ + + EEG + +G P+G S +
Sbjct: 492 --LDSPPPSPITEASEAAEAAEAGNLAVSSREEG----VSQQGQGAGSAPSGSGSSWVQG 545
Query: 449 GSPSRSPQGLRNRGDGHISQQVPAGANGLAGHPLKPLP 486
PS S L +GDG Q PA PL+PLP
Sbjct: 546 DDPSMS---LTQKGDGESQPQFPA-------VPLEPLP 573
Score = 30.0 bits (66), Expect = 8.8
Identities = 28/104 (26%), Positives = 38/104 (36%), Gaps = 15/104 (14%)
Query: 86 LQRPREPPAAAPSAGGAAPCSP------RGARRGEPPQQQPRRRR-------REKEPEEE 132
+ +P P + APS+ P SP G+ G P P + + PE
Sbjct: 267 ISKPWIPSSPAPSSENGGPASPGLPAEASGSGPGSPHLHPPDKSSPCHSQLLEAQTPEAS 326
Query: 133 PAG-AAARAADAACNGLPGSDSRRAPGKGGGSKGSP-GQRPPVP 174
A A A LP SR P G ++G+P RP P
Sbjct: 327 QASPCPAVTPSAPSAALPDEGSRHTPSPGLPAEGAPEAPRPSSP 370
>gi|116875852 HECT domain and ankyrin repeat containing, E3
ubiquitin protein ligase 1 [Homo sapiens]
Length = 909
Score = 49.3 bits (116), Expect = 1e-05
Identities = 31/93 (33%), Positives = 48/93 (51%), Gaps = 7/93 (7%)
Query: 631 GYTALHWIAKHGDLRALQDLVSGAKKAGIVLDVNVRSSCGYTPLHLAAIHGHQGVIKLLV 690
G TA+HW+A +G L DLV V DV+V + G T LH+A +GH+ ++ L+
Sbjct: 131 GLTAIHWLAVNGRTELLHDLVQH------VSDVDVEDAMGQTALHVACQNGHKTTVQCLL 184
Query: 691 QRLASRVNVRDSSGKKPWQYLTSNTSGEIWQLL 723
A +N + SG P + S+ + Q+L
Sbjct: 185 DSGAD-INRPNVSGATPLYFACSHGQRDTAQIL 216
Score = 37.0 bits (84), Expect = 0.072
Identities = 23/77 (29%), Positives = 43/77 (55%), Gaps = 7/77 (9%)
Query: 629 LTGYTALHWIAKHGDLRALQDLVSGAKKAGIVLDVNVRSSCGYTPLHLAAIHGHQGVIKL 688
++G T LH A++G + + L+ + DVN+ ++ G T +H A++G ++
Sbjct: 96 ISGCTPLHLAARNGQKKCMSKLLEYSA------DVNICNNEGLTAIHWLAVNGRTELLHD 149
Query: 689 LVQRLASRVNVRDSSGK 705
LVQ + S V+V D+ G+
Sbjct: 150 LVQHV-SDVDVEDAMGQ 165
Score = 36.2 bits (82), Expect = 0.12
Identities = 29/94 (30%), Positives = 44/94 (46%), Gaps = 10/94 (10%)
Query: 631 GYTALHWIAKHGDLRALQDLV-SGAKKAGIVLDVNVRSSCGYTPLHLAAIHGHQGVIKLL 689
G TALH ++G +Q L+ SGA D+N + G TPL+ A HG + ++L
Sbjct: 164 GQTALHVACQNGHKTTVQCLLDSGA-------DINRPNVSGATPLYFACSHGQRDTAQIL 216
Query: 690 VQRLASRVNVRDSSGKKPWQYLTSNTSGEIWQLL 723
+ R A + D +G P GE ++L
Sbjct: 217 LLRGAK--YLPDKNGVTPLDLCVQGGYGETCEVL 248
>gi|150170670 piccolo isoform 2 [Homo sapiens]
Length = 4935
Score = 49.3 bits (116), Expect = 1e-05
Identities = 67/283 (23%), Positives = 100/283 (35%), Gaps = 40/283 (14%)
Query: 86 LQRPREPPAAAPSAGGAAPCSPRGARRGEPPQQQPRRRRREKEPEEEPAGAAARAADAAC 145
L P +PP P+ G +PP QQP + + P + PA + A
Sbjct: 298 LPSPSKPPIQQPTPG-------------KPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQ 344
Query: 146 NGLPGSDSRRAPGKGGGSKGSPGQR--PPVPAAAAAGAQARAS-----CAAAKTQGRCCW 198
PG+ + P + G+ P Q P P A G++ +S A A+ G
Sbjct: 345 Q--PGTV--KPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPG---- 396
Query: 199 ECLQNNLAVLPGELGALPHSATAEEKPARALPAQDDRGASREREEGALAEPAP--VPAVA 256
+ A PG P KP P + + + +P P +PA
Sbjct: 397 --VGKTPAQQPGPAKP-PTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQ 453
Query: 257 HSPPATVEAATSRASPPALLPGPA-PRGDRPELLTPSSLHYSTLQQQQQRTREWVARHPQ 315
P T T PP+ LPGPA P +P P + + Q+ PQ
Sbjct: 454 AGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGS-TKPPPQ 512
Query: 316 VPEARDQGPIRAWSVLPDNFLQLPLEPGSTEPNSEPPDPCLSS 358
P P + S P + +PGS +P+++ P P S
Sbjct: 513 QPGPAKPSPQQPGSTKPPS-----QQPGSAKPSAQQPSPAKPS 550
>gi|150378539 piccolo isoform 1 [Homo sapiens]
Length = 5142
Score = 49.3 bits (116), Expect = 1e-05
Identities = 67/283 (23%), Positives = 100/283 (35%), Gaps = 40/283 (14%)
Query: 86 LQRPREPPAAAPSAGGAAPCSPRGARRGEPPQQQPRRRRREKEPEEEPAGAAARAADAAC 145
L P +PP P+ G +PP QQP + + P + PA + A
Sbjct: 298 LPSPSKPPIQQPTPG-------------KPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQ 344
Query: 146 NGLPGSDSRRAPGKGGGSKGSPGQR--PPVPAAAAAGAQARAS-----CAAAKTQGRCCW 198
PG+ + P + G+ P Q P P A G++ +S A A+ G
Sbjct: 345 Q--PGTV--KPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPG---- 396
Query: 199 ECLQNNLAVLPGELGALPHSATAEEKPARALPAQDDRGASREREEGALAEPAP--VPAVA 256
+ A PG P KP P + + + +P P +PA
Sbjct: 397 --VGKTPAQQPGPAKP-PTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQ 453
Query: 257 HSPPATVEAATSRASPPALLPGPA-PRGDRPELLTPSSLHYSTLQQQQQRTREWVARHPQ 315
P T T PP+ LPGPA P +P P + + Q+ PQ
Sbjct: 454 AGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGS-TKPPPQ 512
Query: 316 VPEARDQGPIRAWSVLPDNFLQLPLEPGSTEPNSEPPDPCLSS 358
P P + S P + +PGS +P+++ P P S
Sbjct: 513 QPGPAKPSPQQPGSTKPPS-----QQPGSAKPSAQQPSPAKPS 550
>gi|13540521 basic helix-loop-helix domain containing, class B, 3
[Homo sapiens]
Length = 482
Score = 49.3 bits (116), Expect = 1e-05
Identities = 79/317 (24%), Positives = 99/317 (31%), Gaps = 81/317 (25%)
Query: 87 QRPREPPAAAPSAGG--AAPCSPRGARRGEP--------PQQQPRRR------------- 123
Q P APSA G AAPC R ++ EP + QP
Sbjct: 183 QVPLSKGTGAPSAAGSAAAPCLERAGQKLEPLAYCVPVIQRTQPSAELAAENDTDTDSGY 242
Query: 124 --RREKEPEEEPAGAAARAADAACNGLPGSDS-----RRAPGKGGGSKGSPGQRPPVPAA 176
E P+ E A + PG DS + +GGGS G PG AA
Sbjct: 243 GGEAEARPDREKGKGAGASRVTIKQEPPGEDSPAPKRMKLDSRGGGSGGGPGGGAAAAAA 302
Query: 177 AAAGAQARASCAAAKTQGRCCWECLQNNLAVLPGELGA-LPHSATA-------------E 222
A G A+ A + L ++L G GA P A A
Sbjct: 303 ALLGPDPAAAAALLRPDA-----ALLSSLVAFGGGGGAPFPQPAAAAAPFCLPFCFLSPS 357
Query: 223 EKPARALPAQDDRGASREREEGALAEPAP-----VPAVAHSPPATVEAATSRASPP---- 273
A P D G + A A P P +PA A + A AA + A+ P
Sbjct: 358 AAAAYVQPFLDKSGLEKYLYPAAAAAPFPLLYPGIPAPAAAAAAAAAAAAAAAAFPCLSS 417
Query: 274 ALLPGPAPRGDRPELLTPSSLHYSTLQQQQQRTREWVARHPQVPEARDQGPIRAWSVLPD 333
L P P G L P A HPQ P R P
Sbjct: 418 VLSPPPEKAGAAAATLLP------------HEVAPLGAPHPQHPHGRTHLPFAG------ 459
Query: 334 NFLQLPLEPGSTEPNSE 350
P EPG+ E +++
Sbjct: 460 -----PREPGNPESSAQ 471
>gi|226509740 SR-related CTD-associated factor 1 [Homo sapiens]
Length = 1312
Score = 48.9 bits (115), Expect = 2e-05
Identities = 123/517 (23%), Positives = 170/517 (32%), Gaps = 108/517 (20%)
Query: 89 PREPPAAAPSAGGAAPCSPRGARRGEPPQQQPRRRRREKEPEEEPAGAAARAA------- 141
P EP + PS+ P SP E +++ E+E EEE G + +
Sbjct: 250 PFEPTGSNPSSSAGTP-SP------EEEEEEEEEEEEEEEDEEEEEGLSQSISRISETLA 302
Query: 142 -----DAACNGLPGSDSRRAPGKGGGSKGSPGQRPPVPAAAAAGAQARASCAAAKTQGRC 196
++ PG +S R + +PG P V + A GA R T+
Sbjct: 303 GIYDDNSLSQDFPGDESPRPDAQPTQPTPAPGTPPQVDSTRADGAMRRRVFVVG-TEAEA 361
Query: 197 CWECLQNNLAVLPGELGALPHSATAEEKPARALPAQDDRGASREREEGALAEPAPVPAVA 256
C E G++ +A P LP D E EEG + +P P +A
Sbjct: 362 CRE----------GKVSVEVVTAGGAALPPPLLPPGDS-----EIEEGEIVQPEEEPRLA 406
Query: 257 HS---------PPATVEAATSRASPPALLPGP-APRGD--------------------RP 286
S P +AT A P P P AP GD P
Sbjct: 407 LSLFRPGGRAARPTPAASATPTAQPLPQPPAPRAPEGDDFLSLHAESDGEGALQVDLGEP 466
Query: 287 ELLTPSS--------LHYSTLQQQQQRTREWVARHPQ-----VPEARDQGPIRAWSVLPD 333
P++ L L Q+++R R+ R P P A P R S
Sbjct: 467 APAPPAADSRWGGLDLRRKILTQRRERYRQ---RSPSPAPAPAPAAAAGPPTRKKSRRER 523
Query: 334 NFLQLPLEPGSTEPNSEPPDPCLSS--HSLFPVVPDESWESWAGNPSLTVFRSIRCQLSL 391
E S+ ++P P +S S D S A + + RS S
Sbjct: 524 KRSGEAKEAASSSSGTQPAPPAPASPWDSKKHRSRDRKPGSHASSSARRRSRSRSRSRST 583
Query: 392 QDLDDFVDQESDGSEESSSGPK-------DSPGASEEGLQVVLGTPDRGKLRNPAGGLSV 444
+ D+ GS S S K SP + RGK R+ GG S
Sbjct: 584 RRRSRSTDRRRGGSRRSRSREKRRRRRRSASPPPATSSSSSSRRERHRGKHRD--GGGSK 641
Query: 445 SRKEGSPSRSPQGLRNRGDGHISQQVPAGANGLAGHPLKPLPWPVPKLRRSLRRSSLAGR 504
+K+ S SR G + GDG S++ PA P P P R S G
Sbjct: 642 KKKKRSRSR---GEKRSGDG--SEKAPA-----------PAPPPSGSTSCGDRDSRRRGA 685
Query: 505 AKLSSSDEEYLDEGLLKRSRRPPRSRKPSKAGTAPSP 541
S D D +KR+ R K G +P+P
Sbjct: 686 VPPSIQDLTDHDLFAIKRTITVGRLDKSDPRGPSPAP 722
Score = 36.6 bits (83), Expect = 0.094
Identities = 41/184 (22%), Positives = 60/184 (32%), Gaps = 35/184 (19%)
Query: 109 GARRGEPPQQQPRRRRREKEPEEEPAGAAARAADAACNGLPGSDSRRAPGKGGGSKGSPG 168
G R G +++ E+E EEE A A A + S + G++ P
Sbjct: 1016 GVRGGAEEEEEEEEEEEEEEEEEEQQPATTTATSTAAAAPSTAPSAGSTAGDSGAEDGPA 1075
Query: 169 QR--------PPVPAAAAAGAQARASCAAAKTQGRCCWECLQNNLAVLPGELGALPHSAT 220
R PP+P AG +C + + L L + +
Sbjct: 1076 SRVSQLPTLPPPMPWNLPAGV-----------------DCTTSGVLALTALLFKMEEANL 1118
Query: 221 AEEKPARALPAQDDRGASREREEGALA-EPAPVPAVAHSPPATVEAATSRASPPALLPGP 279
A A+ L ++ S + +L PAPVP PP LLPG
Sbjct: 1119 ASRAKAQELIQATNQILSHRKPPSSLGMTPAPVPTSLGLPP---------GPSSYLLPGS 1169
Query: 280 APRG 283
P G
Sbjct: 1170 LPLG 1173
Score = 33.1 bits (74), Expect = 1.0
Identities = 50/217 (23%), Positives = 74/217 (34%), Gaps = 44/217 (20%)
Query: 106 SPRGARRGEPPQQQPRRRRREKEPEEEPAGAAARAADAACNGLPGSDSRRAPGKGGGSKG 165
+P + P +P++ + + A A A+ S +R+ GGGS G
Sbjct: 883 APTEMAKAAPGSTKPKKTKVK-------AKAGAKKTKGTKGKTKPSKTRKKVRSGGGSGG 935
Query: 166 SPGQRPPVPAAAAAGAQARASCAAAKTQGRCCWECLQNNLAVLPG--------------- 210
S GQ + A + +QA + A +T W + A +P
Sbjct: 936 SGGQVSLKKSKADSCSQAAGTKGAEETS----WSG-EERAAKVPSTPPPKAAPPPPALTP 990
Query: 211 ------------ELGALPHSATAEEKPARALPAQDDRGASREREEGALAEPAPVPAVAHS 258
E+ LP AT EE R +++ E EE E P A S
Sbjct: 991 DSQTVDSSCKTPEVSFLPEEAT-EEAGVRGGAEEEEEEEEEEEEEEEEEEQQPATTTATS 1049
Query: 259 P----PATVEAATSRASPPALLPGPAPRGDRPELLTP 291
P+T +A S A GPA R + L P
Sbjct: 1050 TAAAAPSTAPSAGSTAGDSGAEDGPASRVSQLPTLPP 1086
>gi|17981699 cyclin-dependent kinase inhibitor 2C [Homo sapiens]
Length = 168
Score = 48.5 bits (114), Expect = 2e-05
Identities = 29/75 (38%), Positives = 39/75 (52%), Gaps = 6/75 (8%)
Query: 630 TGYTALHWIAKHGDLRALQDLVSGAKKAGIVLDVNVRSSCGYTPLHLAAIHGHQGVIKLL 689
TG+ +H A+ G L LQ L+ DVN+ + G PLHLAA GH V++ L
Sbjct: 69 TGFAVIHDAARAGFLDTLQTLLE------FQADVNIEDNEGNLPLHLAAKEGHLRVVEFL 122
Query: 690 VQRLASRVNVRDSSG 704
V+ AS V R+ G
Sbjct: 123 VKHTASNVGHRNHKG 137
>gi|4502751 cyclin-dependent kinase inhibitor 2C [Homo sapiens]
Length = 168
Score = 48.5 bits (114), Expect = 2e-05
Identities = 29/75 (38%), Positives = 39/75 (52%), Gaps = 6/75 (8%)
Query: 630 TGYTALHWIAKHGDLRALQDLVSGAKKAGIVLDVNVRSSCGYTPLHLAAIHGHQGVIKLL 689
TG+ +H A+ G L LQ L+ DVN+ + G PLHLAA GH V++ L
Sbjct: 69 TGFAVIHDAARAGFLDTLQTLLE------FQADVNIEDNEGNLPLHLAAKEGHLRVVEFL 122
Query: 690 VQRLASRVNVRDSSG 704
V+ AS V R+ G
Sbjct: 123 VKHTASNVGHRNHKG 137
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.130 0.396
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,125,636
Number of Sequences: 37866
Number of extensions: 2270303
Number of successful extensions: 20078
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 255
Number of HSP's successfully gapped in prelim test: 1377
Number of HSP's that attempted gapping in prelim test: 13323
Number of HSP's gapped (non-prelim): 6567
length of query: 793
length of database: 18,247,518
effective HSP length: 110
effective length of query: 683
effective length of database: 14,082,258
effective search space: 9618182214
effective search space used: 9618182214
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.