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Search of human proteins with 70995241
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|70995241 ankyrin repeat domain 10 [Homo sapiens]
(420 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|70995241 ankyrin repeat domain 10 [Homo sapiens] 867 0.0
gi|110431370 espin [Homo sapiens] 101 1e-21
gi|32171201 ankyrin repeat domain 37 [Homo sapiens] 100 2e-21
gi|41327752 diabetes related ankyrin repeat protein [Homo sapiens] 87 3e-17
gi|169403959 ankyrin repeat domain 53 isoform a [Homo sapiens] 87 4e-17
gi|169403957 ankyrin repeat domain 53 isoform b [Homo sapiens] 87 4e-17
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 82 1e-15
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 82 1e-15
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 82 1e-15
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 82 1e-15
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 82 1e-15
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 82 1e-15
gi|38327522 cardiac ankyrin repeat protein [Homo sapiens] 82 1e-15
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 80 3e-15
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 80 3e-15
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 80 3e-15
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 78 1e-14
gi|155969701 espin-like [Homo sapiens] 78 1e-14
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi... 77 3e-14
gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiqu... 77 4e-14
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 76 5e-14
gi|18252778 ankyrin repeat and SOCS box-containing protein 2 [Ho... 75 9e-14
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 75 1e-13
gi|22208957 ankyrin repeat and SOCS box-containing protein 13 [H... 73 4e-13
gi|156142199 euchromatic histone-lysine N-methyltransferase 2 is... 73 6e-13
gi|156142197 euchromatic histone-lysine N-methyltransferase 2 is... 73 6e-13
gi|13443014 ankyrin repeat and SOCS box-containing 9 isoform 2 [... 72 7e-13
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 72 7e-13
gi|72534772 ankyrin repeat and SOCS box-containing 9 isoform 1 [... 72 9e-13
gi|55742857 ankyrin repeat domain 6 [Homo sapiens] 71 2e-12
>gi|70995241 ankyrin repeat domain 10 [Homo sapiens]
Length = 420
Score = 867 bits (2239), Expect = 0.0
Identities = 420/420 (100%), Positives = 420/420 (100%)
Query: 1 MSAAGAGAGVEAGFSSEELLSLRFPLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWT 60
MSAAGAGAGVEAGFSSEELLSLRFPLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWT
Sbjct: 1 MSAAGAGAGVEAGFSSEELLSLRFPLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWT 60
Query: 61 PVHWAAHFGKLECLVQLVRAGATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINK 120
PVHWAAHFGKLECLVQLVRAGATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINK
Sbjct: 61 PVHWAAHFGKLECLVQLVRAGATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINK 120
Query: 121 PDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNL 180
PDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNL
Sbjct: 121 PDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNL 180
Query: 181 QNCHLNHFYNNGILNGGHQNVFPNHISVGTNRKRCLEDSEDFGVKKARTEAQSLDSAVPL 240
QNCHLNHFYNNGILNGGHQNVFPNHISVGTNRKRCLEDSEDFGVKKARTEAQSLDSAVPL
Sbjct: 181 QNCHLNHFYNNGILNGGHQNVFPNHISVGTNRKRCLEDSEDFGVKKARTEAQSLDSAVPL 240
Query: 241 TNGDTEDDADKMHVDREFAVVTDMKNSSSVSNTLTNGCVINGHLDFPSTTPLSGMESRNG 300
TNGDTEDDADKMHVDREFAVVTDMKNSSSVSNTLTNGCVINGHLDFPSTTPLSGMESRNG
Sbjct: 241 TNGDTEDDADKMHVDREFAVVTDMKNSSSVSNTLTNGCVINGHLDFPSTTPLSGMESRNG 300
Query: 301 QCLTGTNGISSGLAPGQPFPSSQGSLCISGTEEPEKTLRANPELCGSLHLNGSPSSCIAS 360
QCLTGTNGISSGLAPGQPFPSSQGSLCISGTEEPEKTLRANPELCGSLHLNGSPSSCIAS
Sbjct: 301 QCLTGTNGISSGLAPGQPFPSSQGSLCISGTEEPEKTLRANPELCGSLHLNGSPSSCIAS 360
Query: 361 RPSWVEDIGDNLYYGHYHGFGDTAESIPELNSVVEHSKSVKVQERYDSAVLGTMHLHHGS 420
RPSWVEDIGDNLYYGHYHGFGDTAESIPELNSVVEHSKSVKVQERYDSAVLGTMHLHHGS
Sbjct: 361 RPSWVEDIGDNLYYGHYHGFGDTAESIPELNSVVEHSKSVKVQERYDSAVLGTMHLHHGS 420
>gi|110431370 espin [Homo sapiens]
Length = 854
Score = 101 bits (251), Expect = 1e-21
Identities = 60/166 (36%), Positives = 83/166 (50%), Gaps = 9/166 (5%)
Query: 25 PLHRACRDGDLATLCSLLQQT---PHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAG 81
PL+ AC++G L L+Q+ PHA G TP+H AA G +V LV
Sbjct: 175 PLYLACQEGHLEVTQYLVQECGADPHARAHD-----GMTPLHAAAQMGHSPVIVWLVSCT 229
Query: 82 ATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECI 141
+ T H AA GH + L WL+ G I+ D G TP+H AA +G LEC
Sbjct: 230 DVSLSEQDKDGATAMHFAASRGHTKVLSWLLLHGGEISA-DLWGGTPLHDAAENGELECC 288
Query: 142 SALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNLQNCHLNH 187
LV NGA +D+R+ G TAAD++ G C ++L ++N + H
Sbjct: 289 QILVVNGAELDVRDRDGYTAADLSDFNGHSHCTRYLRTVENLSVEH 334
Score = 65.9 bits (159), Expect = 7e-11
Identities = 38/89 (42%), Positives = 47/89 (52%), Gaps = 1/89 (1%)
Query: 61 PVHWAAHFGKLECLVQLVRAGATLNVSTTRYAQTPAHIAAFGGHPQCLVWLI-QAGANIN 119
PVH AA GKL CL LV A + R TPAH A+ GH CL WL+ Q G +
Sbjct: 39 PVHHAARAGKLHCLRFLVEEAALPAAARARNGATPAHDASATGHLACLQWLLSQGGCRVQ 98
Query: 120 KPDCEGETPIHKAARSGSLECISALVANG 148
D G T +H AAR G E ++ L+ +G
Sbjct: 99 DKDNSGATVLHLAARFGHPEVVNWLLHHG 127
Score = 61.2 bits (147), Expect = 2e-09
Identities = 50/161 (31%), Positives = 72/161 (44%), Gaps = 6/161 (3%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
P+H A R G L L L+++ A A+ + G TP H A+ G L CL L+ G
Sbjct: 39 PVHHAARAGKLHCLRFLVEEA--ALPAAARARNGATPAHDASATGHLACLQWLLSQGGCR 96
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLI-QAGANINKPDCEGETPIHKAARSGSLECISA 143
T H+AA GHP+ + WL+ G + G PIH AA G +
Sbjct: 97 VQDKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRL 156
Query: 144 LVANGAH-VDLRNASGLTAADIAQTQGFQECAQFLLNLQNC 183
LV + V+ + +G T +A +G E Q+L +Q C
Sbjct: 157 LVEHYPEGVNAQTKNGATPLYLACQEGHLEVTQYL--VQEC 195
Score = 41.2 bits (95), Expect = 0.002
Identities = 24/66 (36%), Positives = 32/66 (48%), Gaps = 1/66 (1%)
Query: 128 PIHKAARSGSLECISALVANGA-HVDLRNASGLTAADIAQTQGFQECAQFLLNLQNCHLN 186
P+H AAR+G L C+ LV A R +G T A A G C Q+LL+ C +
Sbjct: 39 PVHHAARAGKLHCLRFLVEEAALPAAARARNGATPAHDASATGHLACLQWLLSQGGCRVQ 98
Query: 187 HFYNNG 192
N+G
Sbjct: 99 DKDNSG 104
>gi|32171201 ankyrin repeat domain 37 [Homo sapiens]
Length = 158
Score = 100 bits (250), Expect = 2e-21
Identities = 49/112 (43%), Positives = 74/112 (66%)
Query: 70 KLECLVQLVRAGATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPI 129
+++ L L+ GA++N Q+P H+AA G L+W +Q GA++N+ D GE P+
Sbjct: 9 EVDGLKHLLETGASVNAPPDPCKQSPVHLAAGSGLACFLLWQLQTGADLNQQDVLGEAPL 68
Query: 130 HKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNLQ 181
HKAA+ GSLEC+S LVA+ A +DL N +G TA D+A + GF +CA+FL ++
Sbjct: 69 HKAAKVGSLECLSLLVASDAQIDLCNKNGQTAEDLAWSCGFPDCAKFLTTIK 120
Score = 40.0 bits (92), Expect = 0.004
Identities = 32/107 (29%), Positives = 47/107 (43%), Gaps = 12/107 (11%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
P+H A G C LL Q ++ G P+H AA G LECL LV + A +
Sbjct: 34 PVHLAAGSG---LACFLLWQLQTGADLNQQDVLGEAPLHKAAKVGSLECLSLLVASDAQI 90
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWL--------IQAGANINKPDC 123
++ + QT +A G P C +L I+A + ++ DC
Sbjct: 91 DL-CNKNGQTAEDLAWSCGFPDCAKFLTTIKCMQTIKASEHPDRNDC 136
>gi|41327752 diabetes related ankyrin repeat protein [Homo sapiens]
Length = 305
Score = 87.0 bits (214), Expect = 3e-17
Identities = 56/155 (36%), Positives = 81/155 (52%), Gaps = 6/155 (3%)
Query: 23 RFPLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGA 82
R LH AC G + LL A + + D TPV WA G L L QL+ GA
Sbjct: 145 RTALHWACLKGHSQLVNKLL--VAGATVDARD-LLDRTPVFWACRGGHLVILKQLLNQGA 201
Query: 83 TLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECIS 142
+N + + TP H+A HP CL LI+ GA++N D EG+T +H+A R GS + +
Sbjct: 202 RVN-ARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMK 260
Query: 143 ALVANGAHVDLRNASGLTAADIAQ--TQGFQECAQ 175
L+ GA + +RNA+ +T +A+ +G +E Q
Sbjct: 261 LLLLYGAELGVRNAASVTPVQLARDWQRGIREALQ 295
Score = 65.5 bits (158), Expect = 9e-11
Identities = 40/119 (33%), Positives = 61/119 (51%), Gaps = 1/119 (0%)
Query: 60 TPVHWAAHFGKLECLVQLVRAGATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANIN 119
T +HWA G + + +L+ AGAT++ +TP A GGH L L+ GA +N
Sbjct: 146 TALHWACLKGHSQLVNKLLVAGATVDARDL-LDRTPVFWACRGGHLVILKQLLNQGARVN 204
Query: 120 KPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
D G TP+H A R+ +C+ L+ GAH++ ++ G TA A G + + LL
Sbjct: 205 ARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLL 263
Score = 49.7 bits (117), Expect = 5e-06
Identities = 30/94 (31%), Positives = 44/94 (46%), Gaps = 1/94 (1%)
Query: 93 QTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVD 152
+T H A GH Q + L+ AGA ++ D TP+ A R G L + L+ GA V+
Sbjct: 145 RTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVN 204
Query: 153 LRNASGLTAADIAQTQGFQECAQFLLNLQNCHLN 186
R+ G T +A +C + L+ HLN
Sbjct: 205 ARDKIGSTPLHVAVRTRHPDCLEHLIEC-GAHLN 237
>gi|169403959 ankyrin repeat domain 53 isoform a [Homo sapiens]
Length = 530
Score = 86.7 bits (213), Expect = 4e-17
Identities = 45/124 (36%), Positives = 68/124 (54%), Gaps = 4/124 (3%)
Query: 58 GWTPVHWAAHFGKLECLVQLVRAGATLNVSTTRYAQTPAHIAAFGGHPQ----CLVWLIQ 113
G+T +H+AA +GKL CL LV T +QTP H+ + C+ +L++
Sbjct: 140 GFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLE 199
Query: 114 AGANINKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQEC 173
GA++N C G TP+H AAR G L+C+ LV +GA+V ++A G D + + C
Sbjct: 200 KGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRAC 259
Query: 174 AQFL 177
A+FL
Sbjct: 260 ARFL 263
>gi|169403957 ankyrin repeat domain 53 isoform b [Homo sapiens]
Length = 343
Score = 86.7 bits (213), Expect = 4e-17
Identities = 45/124 (36%), Positives = 68/124 (54%), Gaps = 4/124 (3%)
Query: 58 GWTPVHWAAHFGKLECLVQLVRAGATLNVSTTRYAQTPAHIAAFGGHPQ----CLVWLIQ 113
G+T +H+AA +GKL CL LV T +QTP H+ + C+ +L++
Sbjct: 140 GFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLE 199
Query: 114 AGANINKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQEC 173
GA++N C G TP+H AAR G L+C+ LV +GA+V ++A G D + + C
Sbjct: 200 KGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRAC 259
Query: 174 AQFL 177
A+FL
Sbjct: 260 ARFL 263
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 81.6 bits (200), Expect = 1e-15
Identities = 51/154 (33%), Positives = 78/154 (50%), Gaps = 4/154 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH AC+ + + LL+ +E G TP+H A+ G L + L++ GA+
Sbjct: 407 PLHIACKKNHVRVMELLLKTGASIDAVTES---GLTPLHVASFMGHLPIVKNLLQRGASP 463
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
NVS + +TP H+AA GH + +L+Q A +N + +TP+H AAR G + L
Sbjct: 464 NVSNVK-VETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLL 522
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
+ N A+ +L +G T IA +G E LL
Sbjct: 523 LENNANPNLATTAGHTPLHIAAREGHVETVLALL 556
Score = 73.2 bits (178), Expect = 4e-13
Identities = 43/146 (29%), Positives = 80/146 (54%), Gaps = 4/146 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A ++G + LL + + +L ++ G TP+H A G + L++ G +
Sbjct: 671 PLHLAAQEGHAEMVALLLSKQANGNLGNKS---GLTPLHLVAQEGHVPVADVLIKHGVMV 727
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
+ +TTR TP H+A+ G+ + + +L+Q A++N G +P+H+AA+ G + ++ L
Sbjct: 728 D-ATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLL 786
Query: 145 VANGAHVDLRNASGLTAADIAQTQGF 170
+ NGA + ++ G T IA+ G+
Sbjct: 787 LKNGASPNEVSSDGTTPLAIAKRLGY 812
Score = 72.4 bits (176), Expect = 7e-13
Identities = 48/154 (31%), Positives = 76/154 (49%), Gaps = 4/154 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A + G + LL++ H + A ++ G TP+H A H L+ + L+ G +
Sbjct: 572 PLHVAAKYGKVRVAELLLERDAHPNAAGKN---GLTPLHVAVHHNNLDIVKLLLPRGGSP 628
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
+ S TP HIAA + L+Q G + N +G TP+H AA+ G E ++ L
Sbjct: 629 H-SPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALL 687
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
++ A+ +L N SGLT + +G A L+
Sbjct: 688 LSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLI 721
Score = 70.1 bits (170), Expect = 4e-12
Identities = 44/152 (28%), Positives = 75/152 (49%), Gaps = 4/152 (2%)
Query: 28 RACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATLNVS 87
RA R G+L L+ + +++ G +H A+ G ++ +V+L+ L +
Sbjct: 51 RAARSGNLDKALDHLRNGVDINTCNQNGLNG---LHLASKEGHVKMVVELLHKEIILE-T 106
Query: 88 TTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVAN 147
TT+ T HIAA G + + L+ GAN+N +G TP++ AA+ LE + L+ N
Sbjct: 107 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 166
Query: 148 GAHVDLRNASGLTAADIAQTQGFQECAQFLLN 179
GA+ ++ G T +A QG + L+N
Sbjct: 167 GANQNVATEDGFTPLAVALQQGHENVVAHLIN 198
Score = 70.1 bits (170), Expect = 4e-12
Identities = 58/187 (31%), Positives = 84/187 (44%), Gaps = 13/187 (6%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A G L + +LLQ+ ++++ TP+H AA G E L++ A +
Sbjct: 440 PLHVASFMGHLPIVKNLLQRGASPNVSNVKVE---TPLHMAARAGHTEVAKYLLQNKAKV 496
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
N + QTP H AA GH + L++ AN N G TP+H AAR G +E + AL
Sbjct: 497 NAKA-KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLAL 555
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNLQNCHLNHFYNNGILNGGHQNVFPN 204
+ A G T +A G A+ LL ++ H N NG+ P
Sbjct: 556 LEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLE-RDAHPNAAGKNGLT--------PL 606
Query: 205 HISVGTN 211
H++V N
Sbjct: 607 HVAVHHN 613
Score = 70.1 bits (170), Expect = 4e-12
Identities = 44/157 (28%), Positives = 76/157 (48%), Gaps = 4/157 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A R+G + T+ +LL++ ++ G+TP+H AA +GK+ L+ A
Sbjct: 539 PLHIAAREGHVETVLALLEKEASQACMTKK---GFTPLHVAAKYGKVRVAELLLERDAHP 595
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
N + + TP H+A + + L+ G + + P G TP+H AA+ +E +L
Sbjct: 596 NAAG-KNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 654
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNLQ 181
+ G + + G+T +A +G E LL+ Q
Sbjct: 655 LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQ 691
Score = 69.7 bits (169), Expect = 5e-12
Identities = 47/157 (29%), Positives = 74/157 (47%), Gaps = 4/157 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A +L + LL + H ++ G+TP+H AA ++E L++ G +
Sbjct: 605 PLHVAVHHNNLDIVKLLLPRGGSPH---SPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA 661
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
N + + TP H+AA GH + + L+ AN N + G TP+H A+ G + L
Sbjct: 662 NAESVQ-GVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVL 720
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNLQ 181
+ +G VD G T +A G + +FLL Q
Sbjct: 721 IKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQ 757
Score = 68.9 bits (167), Expect = 8e-12
Identities = 65/229 (28%), Positives = 92/229 (40%), Gaps = 45/229 (19%)
Query: 22 LRFP-LHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRA 80
+R P LH A R+ D T LLQ P+ + S+ G+TP+H AAH+ L L+
Sbjct: 205 VRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKT---GFTPLHIAAHYENLNVAQLLLNR 261
Query: 81 GATLNVST--------------------------------TRYAQTPAHIAAFGGHPQCL 108
GA++N + T+ TP H AA GH +
Sbjct: 262 GASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 321
Query: 109 VWLIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQ 168
L+ GA I G +PIH AA+ L+C+ L+ A +D LT +A
Sbjct: 322 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHC 381
Query: 169 GFQECAQFLLNLQNCHLNHFYNNGILNGGHQNVFPNHISVGTNRKRCLE 217
G A+ LL+ N+ LNG P HI+ N R +E
Sbjct: 382 GHHRVAKVLLD-----KGAKPNSRALNG----FTPLHIACKKNHVRVME 421
Score = 66.6 bits (161), Expect = 4e-11
Identities = 47/154 (30%), Positives = 71/154 (46%), Gaps = 4/154 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A R G LLQ + ++D TP+H AA G + L+ A
Sbjct: 473 PLHMAARAGHTEVAKYLLQNKAKVNAKAKDD---QTPLHCAARIGHTNMVKLLLENNANP 529
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
N++TT TP HIAA GH + ++ L++ A+ +G TP+H AA+ G + L
Sbjct: 530 NLATTA-GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELL 588
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
+ AH + +GLT +A + + LL
Sbjct: 589 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL 622
Score = 66.2 bits (160), Expect = 5e-11
Identities = 47/154 (30%), Positives = 70/154 (45%), Gaps = 4/154 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A R+G + LL H + G +P+H AA L+C+ L++ A +
Sbjct: 308 PLHCAARNGHVRISEILLD---HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEI 364
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
+ T + TP H+AA GH + L+ GA N G TP+H A + + + L
Sbjct: 365 DDITLDHL-TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELL 423
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
+ GA +D SGLT +A G + LL
Sbjct: 424 LKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL 457
Score = 62.4 bits (150), Expect = 7e-10
Identities = 45/154 (29%), Positives = 71/154 (46%), Gaps = 4/154 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A + + SLLQ + A+ +S G TP+H AA G E + L+ A
Sbjct: 638 PLHIAAKQNQVEVARSLLQ---YGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 694
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
N+ + TP H+ A GH LI+ G ++ G TP+H A+ G+++ + L
Sbjct: 695 NLGN-KSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFL 753
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
+ + A V+ + G + A QG + LL
Sbjct: 754 LQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLL 787
Score = 60.8 bits (146), Expect = 2e-09
Identities = 48/154 (31%), Positives = 69/154 (44%), Gaps = 4/154 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
P+H A + L + LLQ + D TP+H AAH G L+ GA
Sbjct: 341 PIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL---TPLHVAAHCGHHRVAKVLLDKGAKP 397
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
N S TP HIA H + + L++ GA+I+ G TP+H A+ G L + L
Sbjct: 398 N-SRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 456
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
+ GA ++ N T +A G E A++LL
Sbjct: 457 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLL 490
Score = 57.8 bits (138), Expect = 2e-08
Identities = 34/120 (28%), Positives = 61/120 (50%), Gaps = 4/120 (3%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH ++G + L++ H + + G+TP+H A+H+G ++ + L++ A +
Sbjct: 704 PLHLVAQEGHVPVADVLIK---HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADV 760
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
N T + +P H AA GH + L++ GA+ N+ +G TP+ A R G + L
Sbjct: 761 NAKT-KLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 819
Score = 51.2 bits (121), Expect = 2e-06
Identities = 44/151 (29%), Positives = 72/151 (47%), Gaps = 15/151 (9%)
Query: 26 LHRACRDGDLATLCSLLQQTPHAHLASEDSFY-GWTPVHWAAHFGKLECLVQLVRAGATL 84
LH A ++G + + LL H + E + G T +H AA G+ E + +LV GA +
Sbjct: 82 LHLASKEGHVKMVVELL----HKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANV 137
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
N + + TP ++AA H + + +L++ GAN N +G TP+ A + G ++ L
Sbjct: 138 NAQSQK-GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHL 196
Query: 145 VANGA---------HVDLRNASGLTAADIAQ 166
+ G H+ RN TAA + Q
Sbjct: 197 INYGTKGKVRLPALHIAARNDDTRTAAVLLQ 227
Score = 50.1 bits (118), Expect = 4e-06
Identities = 44/156 (28%), Positives = 70/156 (44%), Gaps = 10/156 (6%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PL+ A ++ L + LL+ + ++A+ED G+TP+ A G + L+
Sbjct: 147 PLYMAAQENHLEVVKFLLENGANQNVATED---GFTPLAVALQQGHENVVAHLI------ 197
Query: 85 NVSTTRYAQTPA-HIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISA 143
N T + PA HIAA + L+Q N + G TP+H AA +L
Sbjct: 198 NYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQL 257
Query: 144 LVANGAHVDLRNASGLTAADIAQTQGFQECAQFLLN 179
L+ GA V+ +G+T IA +G + LL+
Sbjct: 258 LLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLD 293
Score = 29.6 bits (65), Expect = 5.4
Identities = 17/60 (28%), Positives = 29/60 (48%)
Query: 120 KPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLLN 179
K + T +AARSG+L+ + NG ++ N +GL +A +G + LL+
Sbjct: 40 KKKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLH 99
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 81.6 bits (200), Expect = 1e-15
Identities = 51/154 (33%), Positives = 78/154 (50%), Gaps = 4/154 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH AC+ + + LL+ +E G TP+H A+ G L + L++ GA+
Sbjct: 374 PLHIACKKNHVRVMELLLKTGASIDAVTES---GLTPLHVASFMGHLPIVKNLLQRGASP 430
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
NVS + +TP H+AA GH + +L+Q A +N + +TP+H AAR G + L
Sbjct: 431 NVSNVK-VETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLL 489
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
+ N A+ +L +G T IA +G E LL
Sbjct: 490 LENNANPNLATTAGHTPLHIAAREGHVETVLALL 523
Score = 73.2 bits (178), Expect = 4e-13
Identities = 43/146 (29%), Positives = 80/146 (54%), Gaps = 4/146 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A ++G + LL + + +L ++ G TP+H A G + L++ G +
Sbjct: 638 PLHLAAQEGHAEMVALLLSKQANGNLGNKS---GLTPLHLVAQEGHVPVADVLIKHGVMV 694
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
+ +TTR TP H+A+ G+ + + +L+Q A++N G +P+H+AA+ G + ++ L
Sbjct: 695 D-ATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLL 753
Query: 145 VANGAHVDLRNASGLTAADIAQTQGF 170
+ NGA + ++ G T IA+ G+
Sbjct: 754 LKNGASPNEVSSDGTTPLAIAKRLGY 779
Score = 72.4 bits (176), Expect = 7e-13
Identities = 48/154 (31%), Positives = 76/154 (49%), Gaps = 4/154 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A + G + LL++ H + A ++ G TP+H A H L+ + L+ G +
Sbjct: 539 PLHVAAKYGKVRVAELLLERDAHPNAAGKN---GLTPLHVAVHHNNLDIVKLLLPRGGSP 595
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
+ S TP HIAA + L+Q G + N +G TP+H AA+ G E ++ L
Sbjct: 596 H-SPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALL 654
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
++ A+ +L N SGLT + +G A L+
Sbjct: 655 LSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLI 688
Score = 70.1 bits (170), Expect = 4e-12
Identities = 44/152 (28%), Positives = 75/152 (49%), Gaps = 4/152 (2%)
Query: 28 RACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATLNVS 87
RA R G+L L+ + +++ G +H A+ G ++ +V+L+ L +
Sbjct: 18 RAARSGNLDKALDHLRNGVDINTCNQNGLNG---LHLASKEGHVKMVVELLHKEIILE-T 73
Query: 88 TTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVAN 147
TT+ T HIAA G + + L+ GAN+N +G TP++ AA+ LE + L+ N
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133
Query: 148 GAHVDLRNASGLTAADIAQTQGFQECAQFLLN 179
GA+ ++ G T +A QG + L+N
Sbjct: 134 GANQNVATEDGFTPLAVALQQGHENVVAHLIN 165
Score = 70.1 bits (170), Expect = 4e-12
Identities = 58/187 (31%), Positives = 84/187 (44%), Gaps = 13/187 (6%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A G L + +LLQ+ ++++ TP+H AA G E L++ A +
Sbjct: 407 PLHVASFMGHLPIVKNLLQRGASPNVSNVKVE---TPLHMAARAGHTEVAKYLLQNKAKV 463
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
N + QTP H AA GH + L++ AN N G TP+H AAR G +E + AL
Sbjct: 464 NAKA-KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLAL 522
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNLQNCHLNHFYNNGILNGGHQNVFPN 204
+ A G T +A G A+ LL ++ H N NG+ P
Sbjct: 523 LEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLE-RDAHPNAAGKNGLT--------PL 573
Query: 205 HISVGTN 211
H++V N
Sbjct: 574 HVAVHHN 580
Score = 70.1 bits (170), Expect = 4e-12
Identities = 44/157 (28%), Positives = 76/157 (48%), Gaps = 4/157 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A R+G + T+ +LL++ ++ G+TP+H AA +GK+ L+ A
Sbjct: 506 PLHIAAREGHVETVLALLEKEASQACMTKK---GFTPLHVAAKYGKVRVAELLLERDAHP 562
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
N + + TP H+A + + L+ G + + P G TP+H AA+ +E +L
Sbjct: 563 NAAG-KNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 621
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNLQ 181
+ G + + G+T +A +G E LL+ Q
Sbjct: 622 LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQ 658
Score = 69.7 bits (169), Expect = 5e-12
Identities = 47/157 (29%), Positives = 74/157 (47%), Gaps = 4/157 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A +L + LL + H ++ G+TP+H AA ++E L++ G +
Sbjct: 572 PLHVAVHHNNLDIVKLLLPRGGSPH---SPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA 628
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
N + + TP H+AA GH + + L+ AN N + G TP+H A+ G + L
Sbjct: 629 NAESVQ-GVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVL 687
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNLQ 181
+ +G VD G T +A G + +FLL Q
Sbjct: 688 IKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQ 724
Score = 68.9 bits (167), Expect = 8e-12
Identities = 65/229 (28%), Positives = 92/229 (40%), Gaps = 45/229 (19%)
Query: 22 LRFP-LHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRA 80
+R P LH A R+ D T LLQ P+ + S+ G+TP+H AAH+ L L+
Sbjct: 172 VRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKT---GFTPLHIAAHYENLNVAQLLLNR 228
Query: 81 GATLNVST--------------------------------TRYAQTPAHIAAFGGHPQCL 108
GA++N + T+ TP H AA GH +
Sbjct: 229 GASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 288
Query: 109 VWLIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQ 168
L+ GA I G +PIH AA+ L+C+ L+ A +D LT +A
Sbjct: 289 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHC 348
Query: 169 GFQECAQFLLNLQNCHLNHFYNNGILNGGHQNVFPNHISVGTNRKRCLE 217
G A+ LL+ N+ LNG P HI+ N R +E
Sbjct: 349 GHHRVAKVLLD-----KGAKPNSRALNG----FTPLHIACKKNHVRVME 388
Score = 66.6 bits (161), Expect = 4e-11
Identities = 47/154 (30%), Positives = 71/154 (46%), Gaps = 4/154 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A R G LLQ + ++D TP+H AA G + L+ A
Sbjct: 440 PLHMAARAGHTEVAKYLLQNKAKVNAKAKDD---QTPLHCAARIGHTNMVKLLLENNANP 496
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
N++TT TP HIAA GH + ++ L++ A+ +G TP+H AA+ G + L
Sbjct: 497 NLATTA-GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELL 555
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
+ AH + +GLT +A + + LL
Sbjct: 556 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL 589
Score = 66.2 bits (160), Expect = 5e-11
Identities = 47/154 (30%), Positives = 70/154 (45%), Gaps = 4/154 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A R+G + LL H + G +P+H AA L+C+ L++ A +
Sbjct: 275 PLHCAARNGHVRISEILLD---HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEI 331
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
+ T + TP H+AA GH + L+ GA N G TP+H A + + + L
Sbjct: 332 DDITLDHL-TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELL 390
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
+ GA +D SGLT +A G + LL
Sbjct: 391 LKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL 424
Score = 62.4 bits (150), Expect = 7e-10
Identities = 45/154 (29%), Positives = 71/154 (46%), Gaps = 4/154 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A + + SLLQ + A+ +S G TP+H AA G E + L+ A
Sbjct: 605 PLHIAAKQNQVEVARSLLQ---YGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 661
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
N+ + TP H+ A GH LI+ G ++ G TP+H A+ G+++ + L
Sbjct: 662 NLGN-KSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFL 720
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
+ + A V+ + G + A QG + LL
Sbjct: 721 LQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLL 754
Score = 60.8 bits (146), Expect = 2e-09
Identities = 48/154 (31%), Positives = 69/154 (44%), Gaps = 4/154 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
P+H A + L + LLQ + D TP+H AAH G L+ GA
Sbjct: 308 PIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL---TPLHVAAHCGHHRVAKVLLDKGAKP 364
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
N S TP HIA H + + L++ GA+I+ G TP+H A+ G L + L
Sbjct: 365 N-SRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 423
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
+ GA ++ N T +A G E A++LL
Sbjct: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLL 457
Score = 57.8 bits (138), Expect = 2e-08
Identities = 34/120 (28%), Positives = 61/120 (50%), Gaps = 4/120 (3%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH ++G + L++ H + + G+TP+H A+H+G ++ + L++ A +
Sbjct: 671 PLHLVAQEGHVPVADVLIK---HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADV 727
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
N T + +P H AA GH + L++ GA+ N+ +G TP+ A R G + L
Sbjct: 728 NAKT-KLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 51.2 bits (121), Expect = 2e-06
Identities = 44/151 (29%), Positives = 72/151 (47%), Gaps = 15/151 (9%)
Query: 26 LHRACRDGDLATLCSLLQQTPHAHLASEDSFY-GWTPVHWAAHFGKLECLVQLVRAGATL 84
LH A ++G + + LL H + E + G T +H AA G+ E + +LV GA +
Sbjct: 49 LHLASKEGHVKMVVELL----HKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANV 104
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
N + + TP ++AA H + + +L++ GAN N +G TP+ A + G ++ L
Sbjct: 105 NAQSQK-GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHL 163
Query: 145 VANGA---------HVDLRNASGLTAADIAQ 166
+ G H+ RN TAA + Q
Sbjct: 164 INYGTKGKVRLPALHIAARNDDTRTAAVLLQ 194
Score = 50.1 bits (118), Expect = 4e-06
Identities = 44/156 (28%), Positives = 70/156 (44%), Gaps = 10/156 (6%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PL+ A ++ L + LL+ + ++A+ED G+TP+ A G + L+
Sbjct: 114 PLYMAAQENHLEVVKFLLENGANQNVATED---GFTPLAVALQQGHENVVAHLI------ 164
Query: 85 NVSTTRYAQTPA-HIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISA 143
N T + PA HIAA + L+Q N + G TP+H AA +L
Sbjct: 165 NYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQL 224
Query: 144 LVANGAHVDLRNASGLTAADIAQTQGFQECAQFLLN 179
L+ GA V+ +G+T IA +G + LL+
Sbjct: 225 LLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLD 260
Score = 29.3 bits (64), Expect = 7.0
Identities = 16/58 (27%), Positives = 29/58 (50%)
Query: 122 DCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLLN 179
+ + T +AARSG+L+ + NG ++ N +GL +A +G + LL+
Sbjct: 9 EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLH 66
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 81.6 bits (200), Expect = 1e-15
Identities = 51/154 (33%), Positives = 78/154 (50%), Gaps = 4/154 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH AC+ + + LL+ +E G TP+H A+ G L + L++ GA+
Sbjct: 374 PLHIACKKNHVRVMELLLKTGASIDAVTES---GLTPLHVASFMGHLPIVKNLLQRGASP 430
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
NVS + +TP H+AA GH + +L+Q A +N + +TP+H AAR G + L
Sbjct: 431 NVSNVK-VETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLL 489
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
+ N A+ +L +G T IA +G E LL
Sbjct: 490 LENNANPNLATTAGHTPLHIAAREGHVETVLALL 523
Score = 73.2 bits (178), Expect = 4e-13
Identities = 43/146 (29%), Positives = 80/146 (54%), Gaps = 4/146 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A ++G + LL + + +L ++ G TP+H A G + L++ G +
Sbjct: 638 PLHLAAQEGHAEMVALLLSKQANGNLGNKS---GLTPLHLVAQEGHVPVADVLIKHGVMV 694
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
+ +TTR TP H+A+ G+ + + +L+Q A++N G +P+H+AA+ G + ++ L
Sbjct: 695 D-ATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLL 753
Query: 145 VANGAHVDLRNASGLTAADIAQTQGF 170
+ NGA + ++ G T IA+ G+
Sbjct: 754 LKNGASPNEVSSDGTTPLAIAKRLGY 779
Score = 72.4 bits (176), Expect = 7e-13
Identities = 48/154 (31%), Positives = 76/154 (49%), Gaps = 4/154 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A + G + LL++ H + A ++ G TP+H A H L+ + L+ G +
Sbjct: 539 PLHVAAKYGKVRVAELLLERDAHPNAAGKN---GLTPLHVAVHHNNLDIVKLLLPRGGSP 595
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
+ S TP HIAA + L+Q G + N +G TP+H AA+ G E ++ L
Sbjct: 596 H-SPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALL 654
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
++ A+ +L N SGLT + +G A L+
Sbjct: 655 LSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLI 688
Score = 70.1 bits (170), Expect = 4e-12
Identities = 44/152 (28%), Positives = 75/152 (49%), Gaps = 4/152 (2%)
Query: 28 RACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATLNVS 87
RA R G+L L+ + +++ G +H A+ G ++ +V+L+ L +
Sbjct: 18 RAARSGNLDKALDHLRNGVDINTCNQNGLNG---LHLASKEGHVKMVVELLHKEIILE-T 73
Query: 88 TTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVAN 147
TT+ T HIAA G + + L+ GAN+N +G TP++ AA+ LE + L+ N
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133
Query: 148 GAHVDLRNASGLTAADIAQTQGFQECAQFLLN 179
GA+ ++ G T +A QG + L+N
Sbjct: 134 GANQNVATEDGFTPLAVALQQGHENVVAHLIN 165
Score = 70.1 bits (170), Expect = 4e-12
Identities = 58/187 (31%), Positives = 84/187 (44%), Gaps = 13/187 (6%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A G L + +LLQ+ ++++ TP+H AA G E L++ A +
Sbjct: 407 PLHVASFMGHLPIVKNLLQRGASPNVSNVKVE---TPLHMAARAGHTEVAKYLLQNKAKV 463
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
N + QTP H AA GH + L++ AN N G TP+H AAR G +E + AL
Sbjct: 464 NAKA-KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLAL 522
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNLQNCHLNHFYNNGILNGGHQNVFPN 204
+ A G T +A G A+ LL ++ H N NG+ P
Sbjct: 523 LEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLE-RDAHPNAAGKNGLT--------PL 573
Query: 205 HISVGTN 211
H++V N
Sbjct: 574 HVAVHHN 580
Score = 70.1 bits (170), Expect = 4e-12
Identities = 44/157 (28%), Positives = 76/157 (48%), Gaps = 4/157 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A R+G + T+ +LL++ ++ G+TP+H AA +GK+ L+ A
Sbjct: 506 PLHIAAREGHVETVLALLEKEASQACMTKK---GFTPLHVAAKYGKVRVAELLLERDAHP 562
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
N + + TP H+A + + L+ G + + P G TP+H AA+ +E +L
Sbjct: 563 NAAG-KNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 621
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNLQ 181
+ G + + G+T +A +G E LL+ Q
Sbjct: 622 LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQ 658
Score = 69.7 bits (169), Expect = 5e-12
Identities = 47/157 (29%), Positives = 74/157 (47%), Gaps = 4/157 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A +L + LL + H ++ G+TP+H AA ++E L++ G +
Sbjct: 572 PLHVAVHHNNLDIVKLLLPRGGSPH---SPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA 628
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
N + + TP H+AA GH + + L+ AN N + G TP+H A+ G + L
Sbjct: 629 NAESVQ-GVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVL 687
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNLQ 181
+ +G VD G T +A G + +FLL Q
Sbjct: 688 IKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQ 724
Score = 68.9 bits (167), Expect = 8e-12
Identities = 65/229 (28%), Positives = 92/229 (40%), Gaps = 45/229 (19%)
Query: 22 LRFP-LHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRA 80
+R P LH A R+ D T LLQ P+ + S+ G+TP+H AAH+ L L+
Sbjct: 172 VRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKT---GFTPLHIAAHYENLNVAQLLLNR 228
Query: 81 GATLNVST--------------------------------TRYAQTPAHIAAFGGHPQCL 108
GA++N + T+ TP H AA GH +
Sbjct: 229 GASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 288
Query: 109 VWLIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQ 168
L+ GA I G +PIH AA+ L+C+ L+ A +D LT +A
Sbjct: 289 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHC 348
Query: 169 GFQECAQFLLNLQNCHLNHFYNNGILNGGHQNVFPNHISVGTNRKRCLE 217
G A+ LL+ N+ LNG P HI+ N R +E
Sbjct: 349 GHHRVAKVLLD-----KGAKPNSRALNG----FTPLHIACKKNHVRVME 388
Score = 66.6 bits (161), Expect = 4e-11
Identities = 47/154 (30%), Positives = 71/154 (46%), Gaps = 4/154 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A R G LLQ + ++D TP+H AA G + L+ A
Sbjct: 440 PLHMAARAGHTEVAKYLLQNKAKVNAKAKDD---QTPLHCAARIGHTNMVKLLLENNANP 496
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
N++TT TP HIAA GH + ++ L++ A+ +G TP+H AA+ G + L
Sbjct: 497 NLATTA-GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELL 555
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
+ AH + +GLT +A + + LL
Sbjct: 556 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL 589
Score = 66.2 bits (160), Expect = 5e-11
Identities = 47/154 (30%), Positives = 70/154 (45%), Gaps = 4/154 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A R+G + LL H + G +P+H AA L+C+ L++ A +
Sbjct: 275 PLHCAARNGHVRISEILLD---HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEI 331
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
+ T + TP H+AA GH + L+ GA N G TP+H A + + + L
Sbjct: 332 DDITLDHL-TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELL 390
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
+ GA +D SGLT +A G + LL
Sbjct: 391 LKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL 424
Score = 62.4 bits (150), Expect = 7e-10
Identities = 45/154 (29%), Positives = 71/154 (46%), Gaps = 4/154 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A + + SLLQ + A+ +S G TP+H AA G E + L+ A
Sbjct: 605 PLHIAAKQNQVEVARSLLQ---YGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 661
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
N+ + TP H+ A GH LI+ G ++ G TP+H A+ G+++ + L
Sbjct: 662 NLGN-KSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFL 720
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
+ + A V+ + G + A QG + LL
Sbjct: 721 LQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLL 754
Score = 60.8 bits (146), Expect = 2e-09
Identities = 48/154 (31%), Positives = 69/154 (44%), Gaps = 4/154 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
P+H A + L + LLQ + D TP+H AAH G L+ GA
Sbjct: 308 PIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL---TPLHVAAHCGHHRVAKVLLDKGAKP 364
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
N S TP HIA H + + L++ GA+I+ G TP+H A+ G L + L
Sbjct: 365 N-SRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 423
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
+ GA ++ N T +A G E A++LL
Sbjct: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLL 457
Score = 57.8 bits (138), Expect = 2e-08
Identities = 34/120 (28%), Positives = 61/120 (50%), Gaps = 4/120 (3%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH ++G + L++ H + + G+TP+H A+H+G ++ + L++ A +
Sbjct: 671 PLHLVAQEGHVPVADVLIK---HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADV 727
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
N T + +P H AA GH + L++ GA+ N+ +G TP+ A R G + L
Sbjct: 728 NAKT-KLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 51.2 bits (121), Expect = 2e-06
Identities = 44/151 (29%), Positives = 72/151 (47%), Gaps = 15/151 (9%)
Query: 26 LHRACRDGDLATLCSLLQQTPHAHLASEDSFY-GWTPVHWAAHFGKLECLVQLVRAGATL 84
LH A ++G + + LL H + E + G T +H AA G+ E + +LV GA +
Sbjct: 49 LHLASKEGHVKMVVELL----HKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANV 104
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
N + + TP ++AA H + + +L++ GAN N +G TP+ A + G ++ L
Sbjct: 105 NAQSQK-GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHL 163
Query: 145 VANGA---------HVDLRNASGLTAADIAQ 166
+ G H+ RN TAA + Q
Sbjct: 164 INYGTKGKVRLPALHIAARNDDTRTAAVLLQ 194
Score = 50.1 bits (118), Expect = 4e-06
Identities = 44/156 (28%), Positives = 70/156 (44%), Gaps = 10/156 (6%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PL+ A ++ L + LL+ + ++A+ED G+TP+ A G + L+
Sbjct: 114 PLYMAAQENHLEVVKFLLENGANQNVATED---GFTPLAVALQQGHENVVAHLI------ 164
Query: 85 NVSTTRYAQTPA-HIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISA 143
N T + PA HIAA + L+Q N + G TP+H AA +L
Sbjct: 165 NYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQL 224
Query: 144 LVANGAHVDLRNASGLTAADIAQTQGFQECAQFLLN 179
L+ GA V+ +G+T IA +G + LL+
Sbjct: 225 LLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLD 260
Score = 29.3 bits (64), Expect = 7.0
Identities = 16/58 (27%), Positives = 29/58 (50%)
Query: 122 DCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLLN 179
+ + T +AARSG+L+ + NG ++ N +GL +A +G + LL+
Sbjct: 9 EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLH 66
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 81.6 bits (200), Expect = 1e-15
Identities = 51/154 (33%), Positives = 78/154 (50%), Gaps = 4/154 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH AC+ + + LL+ +E G TP+H A+ G L + L++ GA+
Sbjct: 374 PLHIACKKNHVRVMELLLKTGASIDAVTES---GLTPLHVASFMGHLPIVKNLLQRGASP 430
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
NVS + +TP H+AA GH + +L+Q A +N + +TP+H AAR G + L
Sbjct: 431 NVSNVK-VETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLL 489
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
+ N A+ +L +G T IA +G E LL
Sbjct: 490 LENNANPNLATTAGHTPLHIAAREGHVETVLALL 523
Score = 73.2 bits (178), Expect = 4e-13
Identities = 43/146 (29%), Positives = 80/146 (54%), Gaps = 4/146 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A ++G + LL + + +L ++ G TP+H A G + L++ G +
Sbjct: 638 PLHLAAQEGHAEMVALLLSKQANGNLGNKS---GLTPLHLVAQEGHVPVADVLIKHGVMV 694
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
+ +TTR TP H+A+ G+ + + +L+Q A++N G +P+H+AA+ G + ++ L
Sbjct: 695 D-ATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLL 753
Query: 145 VANGAHVDLRNASGLTAADIAQTQGF 170
+ NGA + ++ G T IA+ G+
Sbjct: 754 LKNGASPNEVSSDGTTPLAIAKRLGY 779
Score = 72.4 bits (176), Expect = 7e-13
Identities = 48/154 (31%), Positives = 76/154 (49%), Gaps = 4/154 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A + G + LL++ H + A ++ G TP+H A H L+ + L+ G +
Sbjct: 539 PLHVAAKYGKVRVAELLLERDAHPNAAGKN---GLTPLHVAVHHNNLDIVKLLLPRGGSP 595
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
+ S TP HIAA + L+Q G + N +G TP+H AA+ G E ++ L
Sbjct: 596 H-SPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALL 654
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
++ A+ +L N SGLT + +G A L+
Sbjct: 655 LSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLI 688
Score = 70.1 bits (170), Expect = 4e-12
Identities = 44/152 (28%), Positives = 75/152 (49%), Gaps = 4/152 (2%)
Query: 28 RACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATLNVS 87
RA R G+L L+ + +++ G +H A+ G ++ +V+L+ L +
Sbjct: 18 RAARSGNLDKALDHLRNGVDINTCNQNGLNG---LHLASKEGHVKMVVELLHKEIILE-T 73
Query: 88 TTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVAN 147
TT+ T HIAA G + + L+ GAN+N +G TP++ AA+ LE + L+ N
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133
Query: 148 GAHVDLRNASGLTAADIAQTQGFQECAQFLLN 179
GA+ ++ G T +A QG + L+N
Sbjct: 134 GANQNVATEDGFTPLAVALQQGHENVVAHLIN 165
Score = 70.1 bits (170), Expect = 4e-12
Identities = 58/187 (31%), Positives = 84/187 (44%), Gaps = 13/187 (6%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A G L + +LLQ+ ++++ TP+H AA G E L++ A +
Sbjct: 407 PLHVASFMGHLPIVKNLLQRGASPNVSNVKVE---TPLHMAARAGHTEVAKYLLQNKAKV 463
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
N + QTP H AA GH + L++ AN N G TP+H AAR G +E + AL
Sbjct: 464 NAKA-KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLAL 522
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNLQNCHLNHFYNNGILNGGHQNVFPN 204
+ A G T +A G A+ LL ++ H N NG+ P
Sbjct: 523 LEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLE-RDAHPNAAGKNGLT--------PL 573
Query: 205 HISVGTN 211
H++V N
Sbjct: 574 HVAVHHN 580
Score = 70.1 bits (170), Expect = 4e-12
Identities = 44/157 (28%), Positives = 76/157 (48%), Gaps = 4/157 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A R+G + T+ +LL++ ++ G+TP+H AA +GK+ L+ A
Sbjct: 506 PLHIAAREGHVETVLALLEKEASQACMTKK---GFTPLHVAAKYGKVRVAELLLERDAHP 562
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
N + + TP H+A + + L+ G + + P G TP+H AA+ +E +L
Sbjct: 563 NAAG-KNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 621
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNLQ 181
+ G + + G+T +A +G E LL+ Q
Sbjct: 622 LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQ 658
Score = 69.7 bits (169), Expect = 5e-12
Identities = 47/157 (29%), Positives = 74/157 (47%), Gaps = 4/157 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A +L + LL + H ++ G+TP+H AA ++E L++ G +
Sbjct: 572 PLHVAVHHNNLDIVKLLLPRGGSPH---SPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA 628
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
N + + TP H+AA GH + + L+ AN N + G TP+H A+ G + L
Sbjct: 629 NAESVQ-GVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVL 687
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNLQ 181
+ +G VD G T +A G + +FLL Q
Sbjct: 688 IKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQ 724
Score = 68.9 bits (167), Expect = 8e-12
Identities = 65/229 (28%), Positives = 92/229 (40%), Gaps = 45/229 (19%)
Query: 22 LRFP-LHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRA 80
+R P LH A R+ D T LLQ P+ + S+ G+TP+H AAH+ L L+
Sbjct: 172 VRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKT---GFTPLHIAAHYENLNVAQLLLNR 228
Query: 81 GATLNVST--------------------------------TRYAQTPAHIAAFGGHPQCL 108
GA++N + T+ TP H AA GH +
Sbjct: 229 GASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 288
Query: 109 VWLIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQ 168
L+ GA I G +PIH AA+ L+C+ L+ A +D LT +A
Sbjct: 289 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHC 348
Query: 169 GFQECAQFLLNLQNCHLNHFYNNGILNGGHQNVFPNHISVGTNRKRCLE 217
G A+ LL+ N+ LNG P HI+ N R +E
Sbjct: 349 GHHRVAKVLLD-----KGAKPNSRALNG----FTPLHIACKKNHVRVME 388
Score = 66.6 bits (161), Expect = 4e-11
Identities = 47/154 (30%), Positives = 71/154 (46%), Gaps = 4/154 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A R G LLQ + ++D TP+H AA G + L+ A
Sbjct: 440 PLHMAARAGHTEVAKYLLQNKAKVNAKAKDD---QTPLHCAARIGHTNMVKLLLENNANP 496
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
N++TT TP HIAA GH + ++ L++ A+ +G TP+H AA+ G + L
Sbjct: 497 NLATTA-GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELL 555
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
+ AH + +GLT +A + + LL
Sbjct: 556 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL 589
Score = 66.2 bits (160), Expect = 5e-11
Identities = 47/154 (30%), Positives = 70/154 (45%), Gaps = 4/154 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A R+G + LL H + G +P+H AA L+C+ L++ A +
Sbjct: 275 PLHCAARNGHVRISEILLD---HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEI 331
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
+ T + TP H+AA GH + L+ GA N G TP+H A + + + L
Sbjct: 332 DDITLDHL-TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELL 390
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
+ GA +D SGLT +A G + LL
Sbjct: 391 LKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL 424
Score = 62.4 bits (150), Expect = 7e-10
Identities = 45/154 (29%), Positives = 71/154 (46%), Gaps = 4/154 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A + + SLLQ + A+ +S G TP+H AA G E + L+ A
Sbjct: 605 PLHIAAKQNQVEVARSLLQ---YGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 661
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
N+ + TP H+ A GH LI+ G ++ G TP+H A+ G+++ + L
Sbjct: 662 NLGN-KSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFL 720
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
+ + A V+ + G + A QG + LL
Sbjct: 721 LQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLL 754
Score = 60.8 bits (146), Expect = 2e-09
Identities = 48/154 (31%), Positives = 69/154 (44%), Gaps = 4/154 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
P+H A + L + LLQ + D TP+H AAH G L+ GA
Sbjct: 308 PIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL---TPLHVAAHCGHHRVAKVLLDKGAKP 364
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
N S TP HIA H + + L++ GA+I+ G TP+H A+ G L + L
Sbjct: 365 N-SRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 423
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
+ GA ++ N T +A G E A++LL
Sbjct: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLL 457
Score = 57.8 bits (138), Expect = 2e-08
Identities = 34/120 (28%), Positives = 61/120 (50%), Gaps = 4/120 (3%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH ++G + L++ H + + G+TP+H A+H+G ++ + L++ A +
Sbjct: 671 PLHLVAQEGHVPVADVLIK---HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADV 727
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
N T + +P H AA GH + L++ GA+ N+ +G TP+ A R G + L
Sbjct: 728 NAKT-KLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 51.2 bits (121), Expect = 2e-06
Identities = 44/151 (29%), Positives = 72/151 (47%), Gaps = 15/151 (9%)
Query: 26 LHRACRDGDLATLCSLLQQTPHAHLASEDSFY-GWTPVHWAAHFGKLECLVQLVRAGATL 84
LH A ++G + + LL H + E + G T +H AA G+ E + +LV GA +
Sbjct: 49 LHLASKEGHVKMVVELL----HKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANV 104
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
N + + TP ++AA H + + +L++ GAN N +G TP+ A + G ++ L
Sbjct: 105 NAQSQK-GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHL 163
Query: 145 VANGA---------HVDLRNASGLTAADIAQ 166
+ G H+ RN TAA + Q
Sbjct: 164 INYGTKGKVRLPALHIAARNDDTRTAAVLLQ 194
Score = 50.1 bits (118), Expect = 4e-06
Identities = 44/156 (28%), Positives = 70/156 (44%), Gaps = 10/156 (6%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PL+ A ++ L + LL+ + ++A+ED G+TP+ A G + L+
Sbjct: 114 PLYMAAQENHLEVVKFLLENGANQNVATED---GFTPLAVALQQGHENVVAHLI------ 164
Query: 85 NVSTTRYAQTPA-HIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISA 143
N T + PA HIAA + L+Q N + G TP+H AA +L
Sbjct: 165 NYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQL 224
Query: 144 LVANGAHVDLRNASGLTAADIAQTQGFQECAQFLLN 179
L+ GA V+ +G+T IA +G + LL+
Sbjct: 225 LLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLD 260
Score = 29.3 bits (64), Expect = 7.0
Identities = 16/58 (27%), Positives = 29/58 (50%)
Query: 122 DCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLLN 179
+ + T +AARSG+L+ + NG ++ N +GL +A +G + LL+
Sbjct: 9 EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLH 66
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 81.6 bits (200), Expect = 1e-15
Identities = 51/154 (33%), Positives = 78/154 (50%), Gaps = 4/154 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH AC+ + + LL+ +E G TP+H A+ G L + L++ GA+
Sbjct: 374 PLHIACKKNHVRVMELLLKTGASIDAVTES---GLTPLHVASFMGHLPIVKNLLQRGASP 430
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
NVS + +TP H+AA GH + +L+Q A +N + +TP+H AAR G + L
Sbjct: 431 NVSNVK-VETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLL 489
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
+ N A+ +L +G T IA +G E LL
Sbjct: 490 LENNANPNLATTAGHTPLHIAAREGHVETVLALL 523
Score = 73.2 bits (178), Expect = 4e-13
Identities = 43/146 (29%), Positives = 80/146 (54%), Gaps = 4/146 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A ++G + LL + + +L ++ G TP+H A G + L++ G +
Sbjct: 638 PLHLAAQEGHAEMVALLLSKQANGNLGNKS---GLTPLHLVAQEGHVPVADVLIKHGVMV 694
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
+ +TTR TP H+A+ G+ + + +L+Q A++N G +P+H+AA+ G + ++ L
Sbjct: 695 D-ATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLL 753
Query: 145 VANGAHVDLRNASGLTAADIAQTQGF 170
+ NGA + ++ G T IA+ G+
Sbjct: 754 LKNGASPNEVSSDGTTPLAIAKRLGY 779
Score = 72.4 bits (176), Expect = 7e-13
Identities = 48/154 (31%), Positives = 76/154 (49%), Gaps = 4/154 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A + G + LL++ H + A ++ G TP+H A H L+ + L+ G +
Sbjct: 539 PLHVAAKYGKVRVAELLLERDAHPNAAGKN---GLTPLHVAVHHNNLDIVKLLLPRGGSP 595
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
+ S TP HIAA + L+Q G + N +G TP+H AA+ G E ++ L
Sbjct: 596 H-SPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALL 654
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
++ A+ +L N SGLT + +G A L+
Sbjct: 655 LSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLI 688
Score = 70.1 bits (170), Expect = 4e-12
Identities = 44/152 (28%), Positives = 75/152 (49%), Gaps = 4/152 (2%)
Query: 28 RACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATLNVS 87
RA R G+L L+ + +++ G +H A+ G ++ +V+L+ L +
Sbjct: 18 RAARSGNLDKALDHLRNGVDINTCNQNGLNG---LHLASKEGHVKMVVELLHKEIILE-T 73
Query: 88 TTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVAN 147
TT+ T HIAA G + + L+ GAN+N +G TP++ AA+ LE + L+ N
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133
Query: 148 GAHVDLRNASGLTAADIAQTQGFQECAQFLLN 179
GA+ ++ G T +A QG + L+N
Sbjct: 134 GANQNVATEDGFTPLAVALQQGHENVVAHLIN 165
Score = 70.1 bits (170), Expect = 4e-12
Identities = 58/187 (31%), Positives = 84/187 (44%), Gaps = 13/187 (6%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A G L + +LLQ+ ++++ TP+H AA G E L++ A +
Sbjct: 407 PLHVASFMGHLPIVKNLLQRGASPNVSNVKVE---TPLHMAARAGHTEVAKYLLQNKAKV 463
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
N + QTP H AA GH + L++ AN N G TP+H AAR G +E + AL
Sbjct: 464 NAKA-KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLAL 522
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNLQNCHLNHFYNNGILNGGHQNVFPN 204
+ A G T +A G A+ LL ++ H N NG+ P
Sbjct: 523 LEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLE-RDAHPNAAGKNGLT--------PL 573
Query: 205 HISVGTN 211
H++V N
Sbjct: 574 HVAVHHN 580
Score = 70.1 bits (170), Expect = 4e-12
Identities = 44/157 (28%), Positives = 76/157 (48%), Gaps = 4/157 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A R+G + T+ +LL++ ++ G+TP+H AA +GK+ L+ A
Sbjct: 506 PLHIAAREGHVETVLALLEKEASQACMTKK---GFTPLHVAAKYGKVRVAELLLERDAHP 562
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
N + + TP H+A + + L+ G + + P G TP+H AA+ +E +L
Sbjct: 563 NAAG-KNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 621
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNLQ 181
+ G + + G+T +A +G E LL+ Q
Sbjct: 622 LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQ 658
Score = 69.7 bits (169), Expect = 5e-12
Identities = 47/157 (29%), Positives = 74/157 (47%), Gaps = 4/157 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A +L + LL + H ++ G+TP+H AA ++E L++ G +
Sbjct: 572 PLHVAVHHNNLDIVKLLLPRGGSPH---SPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA 628
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
N + + TP H+AA GH + + L+ AN N + G TP+H A+ G + L
Sbjct: 629 NAESVQ-GVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVL 687
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNLQ 181
+ +G VD G T +A G + +FLL Q
Sbjct: 688 IKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQ 724
Score = 68.9 bits (167), Expect = 8e-12
Identities = 65/229 (28%), Positives = 92/229 (40%), Gaps = 45/229 (19%)
Query: 22 LRFP-LHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRA 80
+R P LH A R+ D T LLQ P+ + S+ G+TP+H AAH+ L L+
Sbjct: 172 VRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKT---GFTPLHIAAHYENLNVAQLLLNR 228
Query: 81 GATLNVST--------------------------------TRYAQTPAHIAAFGGHPQCL 108
GA++N + T+ TP H AA GH +
Sbjct: 229 GASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 288
Query: 109 VWLIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQ 168
L+ GA I G +PIH AA+ L+C+ L+ A +D LT +A
Sbjct: 289 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHC 348
Query: 169 GFQECAQFLLNLQNCHLNHFYNNGILNGGHQNVFPNHISVGTNRKRCLE 217
G A+ LL+ N+ LNG P HI+ N R +E
Sbjct: 349 GHHRVAKVLLD-----KGAKPNSRALNG----FTPLHIACKKNHVRVME 388
Score = 66.6 bits (161), Expect = 4e-11
Identities = 47/154 (30%), Positives = 71/154 (46%), Gaps = 4/154 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A R G LLQ + ++D TP+H AA G + L+ A
Sbjct: 440 PLHMAARAGHTEVAKYLLQNKAKVNAKAKDD---QTPLHCAARIGHTNMVKLLLENNANP 496
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
N++TT TP HIAA GH + ++ L++ A+ +G TP+H AA+ G + L
Sbjct: 497 NLATTA-GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELL 555
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
+ AH + +GLT +A + + LL
Sbjct: 556 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL 589
Score = 66.2 bits (160), Expect = 5e-11
Identities = 47/154 (30%), Positives = 70/154 (45%), Gaps = 4/154 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A R+G + LL H + G +P+H AA L+C+ L++ A +
Sbjct: 275 PLHCAARNGHVRISEILLD---HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEI 331
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
+ T + TP H+AA GH + L+ GA N G TP+H A + + + L
Sbjct: 332 DDITLDHL-TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELL 390
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
+ GA +D SGLT +A G + LL
Sbjct: 391 LKTGASIDAVTESGLTPLHVASFMGHLPIVKNLL 424
Score = 62.4 bits (150), Expect = 7e-10
Identities = 45/154 (29%), Positives = 71/154 (46%), Gaps = 4/154 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A + + SLLQ + A+ +S G TP+H AA G E + L+ A
Sbjct: 605 PLHIAAKQNQVEVARSLLQ---YGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 661
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
N+ + TP H+ A GH LI+ G ++ G TP+H A+ G+++ + L
Sbjct: 662 NLGN-KSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFL 720
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
+ + A V+ + G + A QG + LL
Sbjct: 721 LQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLL 754
Score = 60.8 bits (146), Expect = 2e-09
Identities = 48/154 (31%), Positives = 69/154 (44%), Gaps = 4/154 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
P+H A + L + LLQ + D TP+H AAH G L+ GA
Sbjct: 308 PIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL---TPLHVAAHCGHHRVAKVLLDKGAKP 364
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
N S TP HIA H + + L++ GA+I+ G TP+H A+ G L + L
Sbjct: 365 N-SRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 423
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
+ GA ++ N T +A G E A++LL
Sbjct: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLL 457
Score = 57.8 bits (138), Expect = 2e-08
Identities = 34/120 (28%), Positives = 61/120 (50%), Gaps = 4/120 (3%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH ++G + L++ H + + G+TP+H A+H+G ++ + L++ A +
Sbjct: 671 PLHLVAQEGHVPVADVLIK---HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADV 727
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
N T + +P H AA GH + L++ GA+ N+ +G TP+ A R G + L
Sbjct: 728 NAKT-KLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 51.2 bits (121), Expect = 2e-06
Identities = 44/151 (29%), Positives = 72/151 (47%), Gaps = 15/151 (9%)
Query: 26 LHRACRDGDLATLCSLLQQTPHAHLASEDSFY-GWTPVHWAAHFGKLECLVQLVRAGATL 84
LH A ++G + + LL H + E + G T +H AA G+ E + +LV GA +
Sbjct: 49 LHLASKEGHVKMVVELL----HKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANV 104
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
N + + TP ++AA H + + +L++ GAN N +G TP+ A + G ++ L
Sbjct: 105 NAQSQK-GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHL 163
Query: 145 VANGA---------HVDLRNASGLTAADIAQ 166
+ G H+ RN TAA + Q
Sbjct: 164 INYGTKGKVRLPALHIAARNDDTRTAAVLLQ 194
Score = 50.1 bits (118), Expect = 4e-06
Identities = 44/156 (28%), Positives = 70/156 (44%), Gaps = 10/156 (6%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PL+ A ++ L + LL+ + ++A+ED G+TP+ A G + L+
Sbjct: 114 PLYMAAQENHLEVVKFLLENGANQNVATED---GFTPLAVALQQGHENVVAHLI------ 164
Query: 85 NVSTTRYAQTPA-HIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISA 143
N T + PA HIAA + L+Q N + G TP+H AA +L
Sbjct: 165 NYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQL 224
Query: 144 LVANGAHVDLRNASGLTAADIAQTQGFQECAQFLLN 179
L+ GA V+ +G+T IA +G + LL+
Sbjct: 225 LLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLD 260
Score = 29.3 bits (64), Expect = 7.0
Identities = 16/58 (27%), Positives = 29/58 (50%)
Query: 122 DCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLLN 179
+ + T +AARSG+L+ + NG ++ N +GL +A +G + LL+
Sbjct: 9 EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLH 66
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 81.6 bits (200), Expect = 1e-15
Identities = 47/155 (30%), Positives = 79/155 (50%), Gaps = 4/155 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH AC+ + + LL+ +E G TP+H AA G + + QL+ GA+
Sbjct: 403 PLHIACKKNRIKVMELLLKHGASIQAVTES---GLTPIHVAAFMGHVNIVSQLMHHGASP 459
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
N + R +T H+AA G + + +L+Q GA + + +TP+H +AR G + + L
Sbjct: 460 NTTNVR-GETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQL 518
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLLN 179
+ GA + SG T ++ +G ++ A FLL+
Sbjct: 519 LQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLD 553
Score = 80.9 bits (198), Expect = 2e-15
Identities = 51/154 (33%), Positives = 78/154 (50%), Gaps = 4/154 (2%)
Query: 26 LHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATLN 85
LH A R G + L+Q ++D TP+H +A GK + + QL++ GA+ N
Sbjct: 470 LHMAARSGQAEVVRYLVQDGAQVEAKAKDD---QTPLHISARLGKADIVQQLLQQGASPN 526
Query: 86 VSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALV 145
+TT TP H++A GH +L+ GA+++ +G TP+H AA+ G LE + L+
Sbjct: 527 AATTS-GYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLL 585
Query: 146 ANGAHVDLRNASGLTAADIAQTQGFQECAQFLLN 179
A D SGLT +A Q+ A LL+
Sbjct: 586 QKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLD 619
Score = 75.9 bits (185), Expect = 7e-14
Identities = 65/220 (29%), Positives = 98/220 (44%), Gaps = 17/220 (7%)
Query: 22 LRFP-LHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRA 80
+R P LH A R D LLQ +A + S+ G+TP+H AAH+G + L+
Sbjct: 201 VRLPALHIAARKDDTKAAALLLQNDNNADVESKS---GFTPLHIAAHYGNINVATLLLNR 257
Query: 81 GATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLEC 140
A ++ T R TP H+A+ G+ + L+ GA I+ +G TP+H ARSG +
Sbjct: 258 AAAVDF-TARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQV 316
Query: 141 ISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNLQNCHLNHFYNNGILNGGHQN 200
+ L+ A + + +GL+ +A C Q LL N ++ N L H
Sbjct: 317 VEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQ-HNVPVDD-VTNDYLTALHVA 374
Query: 201 VFPNHISVGTNRKRCLEDSEDFGVKKARTEAQSLDSAVPL 240
H V + L D KKA A++L+ PL
Sbjct: 375 AHCGHYKVA----KVLLD------KKANPNAKALNGFTPL 404
Score = 75.5 bits (184), Expect = 9e-14
Identities = 51/162 (31%), Positives = 82/162 (50%), Gaps = 5/162 (3%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A + G L LLQ++ A + G TP+H AAH+ + + L+ GA+
Sbjct: 568 PLHVAAKYGKLEVANLLLQKSASPDAAGKS---GLTPLHVAAHYDNQKVALLLLDQGASP 624
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
+ + + TP HIAA L++ GA+ N +G +H AA+ G ++ +S L
Sbjct: 625 HAAA-KNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLL 683
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNLQNCHLN 186
+ A+V+L N SGLT +A + A+ L+N Q H++
Sbjct: 684 LGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVN-QGAHVD 724
Score = 73.6 bits (179), Expect = 3e-13
Identities = 59/202 (29%), Positives = 85/202 (42%), Gaps = 20/202 (9%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A + LL Q H A+++ G+TP+H AA +++ L+ GA
Sbjct: 601 PLHVAAHYDNQKVALLLLDQGASPHAAAKN---GYTPLHIAAKKNQMDIATTLLEYGADA 657
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
N + TR H+AA GH + L+ AN+N + G TP+H AA+ + L
Sbjct: 658 N-AVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVL 716
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNLQNCHLNHFYNNG------ILNGGH 198
V GAHVD + G T + G + FLL + +N NG GH
Sbjct: 717 VNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQ-HSAKVNAKTKNGYTPLHQAAQQGH 775
Query: 199 ---------QNVFPNHISVGTN 211
N PN ++V N
Sbjct: 776 THIINVLLQNNASPNELTVNGN 797
Score = 72.4 bits (176), Expect = 7e-13
Identities = 42/121 (34%), Positives = 65/121 (53%), Gaps = 1/121 (0%)
Query: 58 GWTPVHWAAHFGKLECLVQLVRAGATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGAN 117
G+TP+H A +++ + L++ GA++ + T TP H+AAF GH + L+ GA+
Sbjct: 400 GFTPLHIACKKNRIKVMELLLKHGASIQ-AVTESGLTPIHVAAFMGHVNIVSQLMHHGAS 458
Query: 118 INKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFL 177
N + GET +H AARSG E + LV +GA V+ + T I+ G + Q L
Sbjct: 459 PNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQL 518
Query: 178 L 178
L
Sbjct: 519 L 519
Score = 67.8 bits (164), Expect = 2e-11
Identities = 42/145 (28%), Positives = 75/145 (51%), Gaps = 4/145 (2%)
Query: 26 LHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATLN 85
+H A ++G + + LL + + +L+++ G TP+H AA ++ LV GA ++
Sbjct: 668 VHLAAQEGHVDMVSLLLGRNANVNLSNKS---GLTPLHLAAQEDRVNVAEVLVNQGAHVD 724
Query: 86 VSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALV 145
T + TP H+ G+ + + +L+Q A +N G TP+H+AA+ G I+ L+
Sbjct: 725 AQT-KMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLL 783
Query: 146 ANGAHVDLRNASGLTAADIAQTQGF 170
N A + +G TA IA+ G+
Sbjct: 784 QNNASPNELTVNGNTALGIARRLGY 808
Score = 66.6 bits (161), Expect = 4e-11
Identities = 42/151 (27%), Positives = 72/151 (47%), Gaps = 4/151 (2%)
Query: 28 RACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATLNVS 87
RA R G L ++ ++ +++ G +H A+ G +E + +L++ A ++ +
Sbjct: 47 RAARAGHLEKALDYIKNGVDINICNQN---GLNALHLASKEGHVEVVSELLQREANVDAA 103
Query: 88 TTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVAN 147
T + T HIA+ G + + L+ GAN+N G TP++ AA+ LE + L+ N
Sbjct: 104 TKK-GNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDN 162
Query: 148 GAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
GA L G T +A QG + LL
Sbjct: 163 GASQSLATEDGFTPLAVALQQGHDQVVSLLL 193
Score = 60.5 bits (145), Expect = 3e-09
Identities = 34/115 (29%), Positives = 60/115 (52%), Gaps = 1/115 (0%)
Query: 65 AAHFGKLECLVQLVRAGATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCE 124
AA G LE + ++ G +N+ H+A+ GH + + L+Q AN++ +
Sbjct: 48 AARAGHLEKALDYIKNGVDINICNQN-GLNALHLASKEGHVEVVSELLQREANVDAATKK 106
Query: 125 GETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLLN 179
G T +H A+ +G E + LV NGA+V+ ++ +G T +A + E +FLL+
Sbjct: 107 GNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLD 161
Score = 60.1 bits (144), Expect = 4e-09
Identities = 52/172 (30%), Positives = 79/172 (45%), Gaps = 9/172 (5%)
Query: 7 GAGVEAGFSSEELLSLRFPLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAA 66
GA VEA ++ PLH + R G + LLQQ + A+ G+TP+H +A
Sbjct: 489 GAQVEAKAKDDQT-----PLHISARLGKADIVQQLLQQGASPNAATTS---GYTPLHLSA 540
Query: 67 HFGKLECLVQLVRAGATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGE 126
G + L+ GA+L++ TT+ TP H+AA G + L+Q A+ + G
Sbjct: 541 REGHEDVAAFLLDHGASLSI-TTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGL 599
Query: 127 TPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
TP+H AA + + L+ GA +G T IA + + A LL
Sbjct: 600 TPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLL 651
Score = 57.0 bits (136), Expect = 3e-08
Identities = 68/282 (24%), Positives = 119/282 (42%), Gaps = 37/282 (13%)
Query: 26 LHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATLN 85
LH A ++G + + LLQ+ + A++ G T +H A+ G+ E + LV GA +N
Sbjct: 78 LHLASKEGHVEVVSELLQREANVDAATKK---GNTALHIASLAGQAEVVKVLVTNGANVN 134
Query: 86 VSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALV 145
+ TP ++AA H + + +L+ GA+ + +G TP+ A + G + +S L+
Sbjct: 135 AQSQN-GFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLL 193
Query: 146 ANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNLQN------------CHLNHFYNN-- 191
N D + L A IA + + A LL N H+ Y N
Sbjct: 194 EN----DTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNIN 249
Query: 192 ---GILN-------GGHQNVFPNHISVGTNRKRCLEDSEDFGVKKARTEAQSLDSAVPLT 241
+LN ++ P H++ ++ D G A+ +A++ D PL
Sbjct: 250 VATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRG---AKIDAKTRDGLTPLH 306
Query: 242 NG--DTEDDADKMHVDREFAVVTDMKNSSSVSNTLTNGCVIN 281
G + +M +DR +++ KN S + T G +N
Sbjct: 307 CGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLN 348
Score = 56.2 bits (134), Expect = 5e-08
Identities = 42/145 (28%), Positives = 65/145 (44%), Gaps = 4/145 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH R G + LL + A + S+ G +P+H A L C+ L++ +
Sbjct: 304 PLHCGARSGHEQVVEMLLDRA--APILSKTK-NGLSPLHMATQGDHLNCVQLLLQHNVPV 360
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
+ T Y T H+AA GH + L+ AN N G TP+H A + ++ + L
Sbjct: 361 DDVTNDYL-TALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELL 419
Query: 145 VANGAHVDLRNASGLTAADIAQTQG 169
+ +GA + SGLT +A G
Sbjct: 420 LKHGASIQAVTESGLTPIHVAAFMG 444
Score = 52.0 bits (123), Expect = 1e-06
Identities = 34/120 (28%), Positives = 57/120 (47%), Gaps = 4/120 (3%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A ++ + L+ Q H ++ G+TP+H H+G ++ + L++ A +
Sbjct: 700 PLHLAAQEDRVNVAEVLVNQGAHVDAQTK---MGYTPLHVGCHYGNIKIVNFLLQHSAKV 756
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
N T + TP H AA GH + L+Q A+ N+ G T + A R G + + L
Sbjct: 757 NAKT-KNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTL 815
Score = 47.0 bits (110), Expect = 3e-05
Identities = 43/156 (27%), Positives = 67/156 (42%), Gaps = 10/156 (6%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PL+ A ++ L + LL LA+ED G+TP+ A G + + L L
Sbjct: 143 PLYMAAQENHLEVVKFLLDNGASQSLATED---GFTPLAVALQQGHDQVVSLL------L 193
Query: 85 NVSTTRYAQTPA-HIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISA 143
T + PA HIAA + L+Q N + G TP+H AA G++ +
Sbjct: 194 ENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATL 253
Query: 144 LVANGAHVDLRNASGLTAADIAQTQGFQECAQFLLN 179
L+ A VD + +T +A +G + LL+
Sbjct: 254 LLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLD 289
>gi|38327522 cardiac ankyrin repeat protein [Homo sapiens]
Length = 319
Score = 81.6 bits (200), Expect = 1e-15
Identities = 48/142 (33%), Positives = 75/142 (52%), Gaps = 4/142 (2%)
Query: 23 RFPLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGA 82
R LHRAC +G LA + L++ A + D T +HWA+ G L+ L L+ GA
Sbjct: 154 RTALHRACLEGHLAIVEKLMEAG--AQIEFRDMLES-TAIHWASRGGNLDVLKLLLNKGA 210
Query: 83 TLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECIS 142
++ + + T H+A GH +C LI A++N D EG+TP+H A R + I
Sbjct: 211 KIS-ARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIR 269
Query: 143 ALVANGAHVDLRNASGLTAADI 164
L+ GA ++++N +G T D+
Sbjct: 270 LLIMYGADLNIKNCAGKTPMDL 291
Score = 53.9 bits (128), Expect = 3e-07
Identities = 31/88 (35%), Positives = 45/88 (51%)
Query: 91 YAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAH 150
Y +T H A GH + L++AGA I D T IH A+R G+L+ + L+ GA
Sbjct: 152 YKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAK 211
Query: 151 VDLRNASGLTAADIAQTQGFQECAQFLL 178
+ R+ TA +A G ECA+ L+
Sbjct: 212 ISARDKLLSTALHVAVRTGHYECAEHLI 239
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 80.5 bits (197), Expect = 3e-15
Identities = 48/130 (36%), Positives = 71/130 (54%), Gaps = 5/130 (3%)
Query: 58 GWTPVHWAAHFGKLECLVQLVRAGATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGAN 117
G+TP+H A +++ + LV+ GA++ + T TP H+AAF GH ++ L+Q GA+
Sbjct: 377 GFTPLHIACKKNRIKVMELLVKYGASIQ-AITESGLTPIHVAAFMGHLNIVLLLLQNGAS 435
Query: 118 INKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFL 177
+ + GET +H AAR+G +E + L+ NGA VD R T IA G E Q L
Sbjct: 436 PDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLL 495
Query: 178 LNLQNCHLNH 187
L H+ H
Sbjct: 496 LQ----HMAH 501
Score = 78.2 bits (191), Expect = 1e-14
Identities = 53/163 (32%), Positives = 82/163 (50%), Gaps = 7/163 (4%)
Query: 22 LRFP-LHRACRDGDLATLCSLLQQTPHAHLASE-----DSFYGWTPVHWAAHFGKLECLV 75
+R P LH A R D + LLQ +A + S+ + G+TP+H AAH+G +
Sbjct: 170 VRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVAT 229
Query: 76 QLVRAGATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARS 135
L+ GA ++ T R TP H+A+ G+ + L+ G I+ +G TP+H AARS
Sbjct: 230 LLLNRGAAVDF-TARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARS 288
Query: 136 GSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
G + + L+ GA + R +GL+ +A EC + LL
Sbjct: 289 GHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLL 331
Score = 73.9 bits (180), Expect = 2e-13
Identities = 48/160 (30%), Positives = 80/160 (50%), Gaps = 4/160 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH AC+ + + L++ +E G TP+H AA G L ++ L++ GA+
Sbjct: 380 PLHIACKKNRIKVMELLVKYGASIQAITES---GLTPIHVAAFMGHLNIVLLLLQNGASP 436
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
+V+ R +T H+AA G + + L++ GA ++ E +TP+H A+R G E + L
Sbjct: 437 DVTNIR-GETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLL 495
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNLQNCH 184
+ + AH D +G T I+ +G + A LL H
Sbjct: 496 LQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAH 535
Score = 73.9 bits (180), Expect = 2e-13
Identities = 49/153 (32%), Positives = 77/153 (50%), Gaps = 4/153 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A + G L LLQ+ A A ++ G TP+H AAH+ + + L+ GA+
Sbjct: 545 PLHVAAKYGSLDVAKLLLQRRAAADSAGKN---GLTPLHVAAHYDNQKVALLLLEKGASP 601
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
+ +T + TP HIAA Q L+ GA N +G TP+H A++ G + ++ L
Sbjct: 602 H-ATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLL 660
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFL 177
+ GA++ + SGLT+ +A + A L
Sbjct: 661 LDKGANIHMSTKSGLTSLHLAAQEDKVNVADIL 693
Score = 70.9 bits (172), Expect = 2e-12
Identities = 45/146 (30%), Positives = 77/146 (52%), Gaps = 4/146 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A ++G + LL + + H++++ G T +H AA K+ L + GA
Sbjct: 644 PLHLASQEGHTDMVTLLLDKGANIHMSTKS---GLTSLHLAAQEDKVNVADILTKHGADQ 700
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
+ T + TP +A G+ + + +L++ GAN+N G TP+H+AA+ G I+ L
Sbjct: 701 DAHT-KLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVL 759
Query: 145 VANGAHVDLRNASGLTAADIAQTQGF 170
+ +GA + A+G TA IA+ G+
Sbjct: 760 LQHGAKPNATTANGNTALAIAKRLGY 785
Score = 69.3 bits (168), Expect = 6e-12
Identities = 46/163 (28%), Positives = 82/163 (50%), Gaps = 5/163 (3%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH + R+G + LL+ LA++ G+TP+H AA +G L+ L++ A
Sbjct: 512 PLHISAREGQVDVASVLLEAGAAHSLATKK---GFTPLHVAAKYGSLDVAKLLLQRRAAA 568
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
+ S + TP H+AA + + + L++ GA+ + G TP+H AA+ ++ S L
Sbjct: 569 D-SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTL 627
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNL-QNCHLN 186
+ GA ++ G+T +A +G + LL+ N H++
Sbjct: 628 LNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMS 670
Score = 68.9 bits (167), Expect = 8e-12
Identities = 49/168 (29%), Positives = 76/168 (45%), Gaps = 5/168 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A + LL++ H +++ G+TP+H AA +++ L+ GA
Sbjct: 578 PLHVAAHYDNQKVALLLLEKGASPHATAKN---GYTPLHIAAKKNQMQIASTLLNYGAET 634
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
N+ T+ TP H+A+ GH + L+ GANI+ G T +H AA+ + L
Sbjct: 635 NI-VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADIL 693
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNLQNCHLNHFYNNG 192
+GA D G T +A G + FLL Q ++N NG
Sbjct: 694 TKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLK-QGANVNAKTKNG 740
Score = 66.6 bits (161), Expect = 4e-11
Identities = 52/156 (33%), Positives = 77/156 (49%), Gaps = 8/156 (5%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASED--SFYGWTPVHWAAHFGKLECLVQLVRAGA 82
P+H A G L + LLQ AS D + G T +H AA G++E + L+R GA
Sbjct: 413 PIHVAAFMGHLNIVLLLLQNG-----ASPDVTNIRGETALHMAARAGQVEVVRCLLRNGA 467
Query: 83 TLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECIS 142
++ + R QTP HIA+ G + + L+Q A+ + G TP+H +AR G ++ S
Sbjct: 468 LVD-ARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVAS 526
Query: 143 ALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
L+ GA L G T +A G + A+ LL
Sbjct: 527 VLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL 562
Score = 65.5 bits (158), Expect = 9e-11
Identities = 42/151 (27%), Positives = 74/151 (49%), Gaps = 4/151 (2%)
Query: 28 RACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATLNVS 87
RA R G+L + L+ + +++ G +H AA G + + +L+ G++++ S
Sbjct: 16 RAARAGNLDKVVEYLKGGIDINTCNQN---GLNALHLAAKEGHVGLVQELLGRGSSVD-S 71
Query: 88 TTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVAN 147
T+ T HIA+ G + + L++ GANIN G TP++ AA+ ++ + L+ N
Sbjct: 72 ATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLEN 131
Query: 148 GAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
GA+ G T +A QG + LL
Sbjct: 132 GANQSTATEDGFTPLAVALQQGHNQAVAILL 162
Score = 62.4 bits (150), Expect = 7e-10
Identities = 48/153 (31%), Positives = 72/153 (47%), Gaps = 4/153 (2%)
Query: 26 LHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATLN 85
LH A R G + + LL+ + + TP+H A+ GK E + L++ A +
Sbjct: 447 LHMAARAGQVEVVRCLLRNGALVDARAREE---QTPLHIASRLGKTEIVQLLLQHMAHPD 503
Query: 86 VSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALV 145
+TT TP HI+A G L++AGA + +G TP+H AA+ GSL+ L+
Sbjct: 504 AATTN-GYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL 562
Query: 146 ANGAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
A D +GLT +A Q+ A LL
Sbjct: 563 QRRAAADSAGKNGLTPLHVAAHYDNQKVALLLL 595
Score = 61.6 bits (148), Expect = 1e-09
Identities = 49/158 (31%), Positives = 73/158 (46%), Gaps = 6/158 (3%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A R G + LL++ +++ G +P+H AA +EC+ L++ A +
Sbjct: 281 PLHCAARSGHDQVVELLLERGAPLLARTKN---GLSPLHMAAQGDHVECVKHLLQHKAPV 337
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
+ T Y T H+AA GH + L+ AN N G TP+H A + ++ + L
Sbjct: 338 DDVTLDYL-TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELL 396
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNLQN 182
V GA + SGLT +A G LL LQN
Sbjct: 397 VKYGASIQAITESGLTPIHVAAFMGHLNIV--LLLLQN 432
Score = 52.8 bits (125), Expect = 6e-07
Identities = 50/183 (27%), Positives = 87/183 (47%), Gaps = 11/183 (6%)
Query: 26 LHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATLN 85
LH A ++G + + LL + A++ G T +H A+ G+ E + LV+ GA +N
Sbjct: 47 LHLAAKEGHVGLVQELLGRGSSVDSATKK---GNTALHIASLAGQAEVVKVLVKEGANIN 103
Query: 86 VSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALV 145
+ TP ++AA H + +L++ GAN + +G TP+ A + G + ++ L+
Sbjct: 104 AQSQN-GFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL 162
Query: 146 ANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNLQNCHLNHFYNNGILNGGHQNVF-PN 204
N D + L A IA + + A L LQN H + ++N ++ F P
Sbjct: 163 EN----DTKGKVRLPALHIAARKDDTKSAALL--LQNDHNADVQSKMMVNRTTESGFTPL 216
Query: 205 HIS 207
HI+
Sbjct: 217 HIA 219
Score = 51.2 bits (121), Expect = 2e-06
Identities = 37/121 (30%), Positives = 59/121 (48%), Gaps = 8/121 (6%)
Query: 26 LHRACRDGDLATLCSLLQQTPHAHLASEDSF--YGWTPVHWAAHFGKLECLVQLVRAGAT 83
LH A ++ D + +L + H A +D+ G+TP+ A H+G ++ + L++ GA
Sbjct: 678 LHLAAQE-DKVNVADILTK----HGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGAN 732
Query: 84 LNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISA 143
+N T + TP H AA GH + L+Q GA N G T + A R G + +
Sbjct: 733 VNAKT-KNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDT 791
Query: 144 L 144
L
Sbjct: 792 L 792
Score = 47.8 bits (112), Expect = 2e-05
Identities = 44/164 (26%), Positives = 72/164 (43%), Gaps = 18/164 (10%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PL+ A ++ + + LL+ + A+ED G+TP+ A G + + L L
Sbjct: 112 PLYMAAQENHIDVVKYLLENGANQSTATED---GFTPLAVALQQGHNQAVAIL------L 162
Query: 85 NVSTTRYAQTPA-HIAAFGGHPQCLVWLIQAGAN--------INKPDCEGETPIHKAARS 135
T + PA HIAA + L+Q N +N+ G TP+H AA
Sbjct: 163 ENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHY 222
Query: 136 GSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLLN 179
G++ + L+ GA VD +G+T +A +G + LL+
Sbjct: 223 GNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLD 266
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 80.5 bits (197), Expect = 3e-15
Identities = 48/130 (36%), Positives = 71/130 (54%), Gaps = 5/130 (3%)
Query: 58 GWTPVHWAAHFGKLECLVQLVRAGATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGAN 117
G+TP+H A +++ + LV+ GA++ + T TP H+AAF GH ++ L+Q GA+
Sbjct: 398 GFTPLHIACKKNRIKVMELLVKYGASIQ-AITESGLTPIHVAAFMGHLNIVLLLLQNGAS 456
Query: 118 INKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFL 177
+ + GET +H AAR+G +E + L+ NGA VD R T IA G E Q L
Sbjct: 457 PDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLL 516
Query: 178 LNLQNCHLNH 187
L H+ H
Sbjct: 517 LQ----HMAH 522
Score = 78.2 bits (191), Expect = 1e-14
Identities = 53/163 (32%), Positives = 82/163 (50%), Gaps = 7/163 (4%)
Query: 22 LRFP-LHRACRDGDLATLCSLLQQTPHAHLASE-----DSFYGWTPVHWAAHFGKLECLV 75
+R P LH A R D + LLQ +A + S+ + G+TP+H AAH+G +
Sbjct: 191 VRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVAT 250
Query: 76 QLVRAGATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARS 135
L+ GA ++ T R TP H+A+ G+ + L+ G I+ +G TP+H AARS
Sbjct: 251 LLLNRGAAVDF-TARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARS 309
Query: 136 GSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
G + + L+ GA + R +GL+ +A EC + LL
Sbjct: 310 GHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLL 352
Score = 73.9 bits (180), Expect = 2e-13
Identities = 48/160 (30%), Positives = 80/160 (50%), Gaps = 4/160 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH AC+ + + L++ +E G TP+H AA G L ++ L++ GA+
Sbjct: 401 PLHIACKKNRIKVMELLVKYGASIQAITES---GLTPIHVAAFMGHLNIVLLLLQNGASP 457
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
+V+ R +T H+AA G + + L++ GA ++ E +TP+H A+R G E + L
Sbjct: 458 DVTNIR-GETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLL 516
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNLQNCH 184
+ + AH D +G T I+ +G + A LL H
Sbjct: 517 LQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAH 556
Score = 73.9 bits (180), Expect = 2e-13
Identities = 49/153 (32%), Positives = 77/153 (50%), Gaps = 4/153 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A + G L LLQ+ A A ++ G TP+H AAH+ + + L+ GA+
Sbjct: 566 PLHVAAKYGSLDVAKLLLQRRAAADSAGKN---GLTPLHVAAHYDNQKVALLLLEKGASP 622
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
+ +T + TP HIAA Q L+ GA N +G TP+H A++ G + ++ L
Sbjct: 623 H-ATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLL 681
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFL 177
+ GA++ + SGLT+ +A + A L
Sbjct: 682 LDKGANIHMSTKSGLTSLHLAAQEDKVNVADIL 714
Score = 70.9 bits (172), Expect = 2e-12
Identities = 45/146 (30%), Positives = 77/146 (52%), Gaps = 4/146 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A ++G + LL + + H++++ G T +H AA K+ L + GA
Sbjct: 665 PLHLASQEGHTDMVTLLLDKGANIHMSTKS---GLTSLHLAAQEDKVNVADILTKHGADQ 721
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
+ T + TP +A G+ + + +L++ GAN+N G TP+H+AA+ G I+ L
Sbjct: 722 DAHT-KLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVL 780
Query: 145 VANGAHVDLRNASGLTAADIAQTQGF 170
+ +GA + A+G TA IA+ G+
Sbjct: 781 LQHGAKPNATTANGNTALAIAKRLGY 806
Score = 69.3 bits (168), Expect = 6e-12
Identities = 46/163 (28%), Positives = 82/163 (50%), Gaps = 5/163 (3%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH + R+G + LL+ LA++ G+TP+H AA +G L+ L++ A
Sbjct: 533 PLHISAREGQVDVASVLLEAGAAHSLATKK---GFTPLHVAAKYGSLDVAKLLLQRRAAA 589
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
+ S + TP H+AA + + + L++ GA+ + G TP+H AA+ ++ S L
Sbjct: 590 D-SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTL 648
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNL-QNCHLN 186
+ GA ++ G+T +A +G + LL+ N H++
Sbjct: 649 LNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMS 691
Score = 68.9 bits (167), Expect = 8e-12
Identities = 49/168 (29%), Positives = 76/168 (45%), Gaps = 5/168 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A + LL++ H +++ G+TP+H AA +++ L+ GA
Sbjct: 599 PLHVAAHYDNQKVALLLLEKGASPHATAKN---GYTPLHIAAKKNQMQIASTLLNYGAET 655
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
N+ T+ TP H+A+ GH + L+ GANI+ G T +H AA+ + L
Sbjct: 656 NI-VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADIL 714
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNLQNCHLNHFYNNG 192
+GA D G T +A G + FLL Q ++N NG
Sbjct: 715 TKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLK-QGANVNAKTKNG 761
Score = 66.6 bits (161), Expect = 4e-11
Identities = 52/156 (33%), Positives = 77/156 (49%), Gaps = 8/156 (5%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASED--SFYGWTPVHWAAHFGKLECLVQLVRAGA 82
P+H A G L + LLQ AS D + G T +H AA G++E + L+R GA
Sbjct: 434 PIHVAAFMGHLNIVLLLLQNG-----ASPDVTNIRGETALHMAARAGQVEVVRCLLRNGA 488
Query: 83 TLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECIS 142
++ + R QTP HIA+ G + + L+Q A+ + G TP+H +AR G ++ S
Sbjct: 489 LVD-ARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVAS 547
Query: 143 ALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
L+ GA L G T +A G + A+ LL
Sbjct: 548 VLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL 583
Score = 65.5 bits (158), Expect = 9e-11
Identities = 42/151 (27%), Positives = 74/151 (49%), Gaps = 4/151 (2%)
Query: 28 RACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATLNVS 87
RA R G+L + L+ + +++ G +H AA G + + +L+ G++++ S
Sbjct: 37 RAARAGNLDKVVEYLKGGIDINTCNQN---GLNALHLAAKEGHVGLVQELLGRGSSVD-S 92
Query: 88 TTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVAN 147
T+ T HIA+ G + + L++ GANIN G TP++ AA+ ++ + L+ N
Sbjct: 93 ATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLEN 152
Query: 148 GAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
GA+ G T +A QG + LL
Sbjct: 153 GANQSTATEDGFTPLAVALQQGHNQAVAILL 183
Score = 62.4 bits (150), Expect = 7e-10
Identities = 48/153 (31%), Positives = 72/153 (47%), Gaps = 4/153 (2%)
Query: 26 LHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATLN 85
LH A R G + + LL+ + + TP+H A+ GK E + L++ A +
Sbjct: 468 LHMAARAGQVEVVRCLLRNGALVDARAREE---QTPLHIASRLGKTEIVQLLLQHMAHPD 524
Query: 86 VSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALV 145
+TT TP HI+A G L++AGA + +G TP+H AA+ GSL+ L+
Sbjct: 525 AATTN-GYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL 583
Query: 146 ANGAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
A D +GLT +A Q+ A LL
Sbjct: 584 QRRAAADSAGKNGLTPLHVAAHYDNQKVALLLL 616
Score = 61.6 bits (148), Expect = 1e-09
Identities = 49/158 (31%), Positives = 73/158 (46%), Gaps = 6/158 (3%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A R G + LL++ +++ G +P+H AA +EC+ L++ A +
Sbjct: 302 PLHCAARSGHDQVVELLLERGAPLLARTKN---GLSPLHMAAQGDHVECVKHLLQHKAPV 358
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
+ T Y T H+AA GH + L+ AN N G TP+H A + ++ + L
Sbjct: 359 DDVTLDYL-TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELL 417
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNLQN 182
V GA + SGLT +A G LL LQN
Sbjct: 418 VKYGASIQAITESGLTPIHVAAFMGHLNIV--LLLLQN 453
Score = 52.8 bits (125), Expect = 6e-07
Identities = 50/183 (27%), Positives = 87/183 (47%), Gaps = 11/183 (6%)
Query: 26 LHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATLN 85
LH A ++G + + LL + A++ G T +H A+ G+ E + LV+ GA +N
Sbjct: 68 LHLAAKEGHVGLVQELLGRGSSVDSATKK---GNTALHIASLAGQAEVVKVLVKEGANIN 124
Query: 86 VSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALV 145
+ TP ++AA H + +L++ GAN + +G TP+ A + G + ++ L+
Sbjct: 125 AQSQN-GFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL 183
Query: 146 ANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNLQNCHLNHFYNNGILNGGHQNVF-PN 204
N D + L A IA + + A L LQN H + ++N ++ F P
Sbjct: 184 EN----DTKGKVRLPALHIAARKDDTKSAALL--LQNDHNADVQSKMMVNRTTESGFTPL 237
Query: 205 HIS 207
HI+
Sbjct: 238 HIA 240
Score = 51.2 bits (121), Expect = 2e-06
Identities = 37/121 (30%), Positives = 59/121 (48%), Gaps = 8/121 (6%)
Query: 26 LHRACRDGDLATLCSLLQQTPHAHLASEDSF--YGWTPVHWAAHFGKLECLVQLVRAGAT 83
LH A ++ D + +L + H A +D+ G+TP+ A H+G ++ + L++ GA
Sbjct: 699 LHLAAQE-DKVNVADILTK----HGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGAN 753
Query: 84 LNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISA 143
+N T + TP H AA GH + L+Q GA N G T + A R G + +
Sbjct: 754 VNAKT-KNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDT 812
Query: 144 L 144
L
Sbjct: 813 L 813
Score = 47.8 bits (112), Expect = 2e-05
Identities = 44/164 (26%), Positives = 72/164 (43%), Gaps = 18/164 (10%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PL+ A ++ + + LL+ + A+ED G+TP+ A G + + L L
Sbjct: 133 PLYMAAQENHIDVVKYLLENGANQSTATED---GFTPLAVALQQGHNQAVAIL------L 183
Query: 85 NVSTTRYAQTPA-HIAAFGGHPQCLVWLIQAGAN--------INKPDCEGETPIHKAARS 135
T + PA HIAA + L+Q N +N+ G TP+H AA
Sbjct: 184 ENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHY 243
Query: 136 GSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLLN 179
G++ + L+ GA VD +G+T +A +G + LL+
Sbjct: 244 GNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLD 287
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 80.5 bits (197), Expect = 3e-15
Identities = 48/130 (36%), Positives = 71/130 (54%), Gaps = 5/130 (3%)
Query: 58 GWTPVHWAAHFGKLECLVQLVRAGATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGAN 117
G+TP+H A +++ + LV+ GA++ + T TP H+AAF GH ++ L+Q GA+
Sbjct: 398 GFTPLHIACKKNRIKVMELLVKYGASIQ-AITESGLTPIHVAAFMGHLNIVLLLLQNGAS 456
Query: 118 INKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFL 177
+ + GET +H AAR+G +E + L+ NGA VD R T IA G E Q L
Sbjct: 457 PDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLL 516
Query: 178 LNLQNCHLNH 187
L H+ H
Sbjct: 517 LQ----HMAH 522
Score = 78.2 bits (191), Expect = 1e-14
Identities = 53/163 (32%), Positives = 82/163 (50%), Gaps = 7/163 (4%)
Query: 22 LRFP-LHRACRDGDLATLCSLLQQTPHAHLASE-----DSFYGWTPVHWAAHFGKLECLV 75
+R P LH A R D + LLQ +A + S+ + G+TP+H AAH+G +
Sbjct: 191 VRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVAT 250
Query: 76 QLVRAGATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARS 135
L+ GA ++ T R TP H+A+ G+ + L+ G I+ +G TP+H AARS
Sbjct: 251 LLLNRGAAVDF-TARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARS 309
Query: 136 GSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
G + + L+ GA + R +GL+ +A EC + LL
Sbjct: 310 GHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLL 352
Score = 73.9 bits (180), Expect = 2e-13
Identities = 48/160 (30%), Positives = 80/160 (50%), Gaps = 4/160 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH AC+ + + L++ +E G TP+H AA G L ++ L++ GA+
Sbjct: 401 PLHIACKKNRIKVMELLVKYGASIQAITES---GLTPIHVAAFMGHLNIVLLLLQNGASP 457
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
+V+ R +T H+AA G + + L++ GA ++ E +TP+H A+R G E + L
Sbjct: 458 DVTNIR-GETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLL 516
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNLQNCH 184
+ + AH D +G T I+ +G + A LL H
Sbjct: 517 LQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAH 556
Score = 73.9 bits (180), Expect = 2e-13
Identities = 49/153 (32%), Positives = 77/153 (50%), Gaps = 4/153 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A + G L LLQ+ A A ++ G TP+H AAH+ + + L+ GA+
Sbjct: 566 PLHVAAKYGSLDVAKLLLQRRAAADSAGKN---GLTPLHVAAHYDNQKVALLLLEKGASP 622
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
+ +T + TP HIAA Q L+ GA N +G TP+H A++ G + ++ L
Sbjct: 623 H-ATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLL 681
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFL 177
+ GA++ + SGLT+ +A + A L
Sbjct: 682 LDKGANIHMSTKSGLTSLHLAAQEDKVNVADIL 714
Score = 70.9 bits (172), Expect = 2e-12
Identities = 45/146 (30%), Positives = 77/146 (52%), Gaps = 4/146 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A ++G + LL + + H++++ G T +H AA K+ L + GA
Sbjct: 665 PLHLASQEGHTDMVTLLLDKGANIHMSTKS---GLTSLHLAAQEDKVNVADILTKHGADQ 721
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
+ T + TP +A G+ + + +L++ GAN+N G TP+H+AA+ G I+ L
Sbjct: 722 DAHT-KLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVL 780
Query: 145 VANGAHVDLRNASGLTAADIAQTQGF 170
+ +GA + A+G TA IA+ G+
Sbjct: 781 LQHGAKPNATTANGNTALAIAKRLGY 806
Score = 69.3 bits (168), Expect = 6e-12
Identities = 46/163 (28%), Positives = 82/163 (50%), Gaps = 5/163 (3%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH + R+G + LL+ LA++ G+TP+H AA +G L+ L++ A
Sbjct: 533 PLHISAREGQVDVASVLLEAGAAHSLATKK---GFTPLHVAAKYGSLDVAKLLLQRRAAA 589
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
+ S + TP H+AA + + + L++ GA+ + G TP+H AA+ ++ S L
Sbjct: 590 D-SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTL 648
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNL-QNCHLN 186
+ GA ++ G+T +A +G + LL+ N H++
Sbjct: 649 LNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMS 691
Score = 68.9 bits (167), Expect = 8e-12
Identities = 49/168 (29%), Positives = 76/168 (45%), Gaps = 5/168 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A + LL++ H +++ G+TP+H AA +++ L+ GA
Sbjct: 599 PLHVAAHYDNQKVALLLLEKGASPHATAKN---GYTPLHIAAKKNQMQIASTLLNYGAET 655
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
N+ T+ TP H+A+ GH + L+ GANI+ G T +H AA+ + L
Sbjct: 656 NI-VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADIL 714
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNLQNCHLNHFYNNG 192
+GA D G T +A G + FLL Q ++N NG
Sbjct: 715 TKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLK-QGANVNAKTKNG 761
Score = 66.6 bits (161), Expect = 4e-11
Identities = 52/156 (33%), Positives = 77/156 (49%), Gaps = 8/156 (5%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASED--SFYGWTPVHWAAHFGKLECLVQLVRAGA 82
P+H A G L + LLQ AS D + G T +H AA G++E + L+R GA
Sbjct: 434 PIHVAAFMGHLNIVLLLLQNG-----ASPDVTNIRGETALHMAARAGQVEVVRCLLRNGA 488
Query: 83 TLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECIS 142
++ + R QTP HIA+ G + + L+Q A+ + G TP+H +AR G ++ S
Sbjct: 489 LVD-ARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVAS 547
Query: 143 ALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
L+ GA L G T +A G + A+ LL
Sbjct: 548 VLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL 583
Score = 65.5 bits (158), Expect = 9e-11
Identities = 42/151 (27%), Positives = 74/151 (49%), Gaps = 4/151 (2%)
Query: 28 RACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATLNVS 87
RA R G+L + L+ + +++ G +H AA G + + +L+ G++++ S
Sbjct: 37 RAARAGNLDKVVEYLKGGIDINTCNQN---GLNALHLAAKEGHVGLVQELLGRGSSVD-S 92
Query: 88 TTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVAN 147
T+ T HIA+ G + + L++ GANIN G TP++ AA+ ++ + L+ N
Sbjct: 93 ATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLEN 152
Query: 148 GAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
GA+ G T +A QG + LL
Sbjct: 153 GANQSTATEDGFTPLAVALQQGHNQAVAILL 183
Score = 62.4 bits (150), Expect = 7e-10
Identities = 48/153 (31%), Positives = 72/153 (47%), Gaps = 4/153 (2%)
Query: 26 LHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATLN 85
LH A R G + + LL+ + + TP+H A+ GK E + L++ A +
Sbjct: 468 LHMAARAGQVEVVRCLLRNGALVDARAREE---QTPLHIASRLGKTEIVQLLLQHMAHPD 524
Query: 86 VSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALV 145
+TT TP HI+A G L++AGA + +G TP+H AA+ GSL+ L+
Sbjct: 525 AATTN-GYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL 583
Query: 146 ANGAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
A D +GLT +A Q+ A LL
Sbjct: 584 QRRAAADSAGKNGLTPLHVAAHYDNQKVALLLL 616
Score = 61.6 bits (148), Expect = 1e-09
Identities = 49/158 (31%), Positives = 73/158 (46%), Gaps = 6/158 (3%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A R G + LL++ +++ G +P+H AA +EC+ L++ A +
Sbjct: 302 PLHCAARSGHDQVVELLLERGAPLLARTKN---GLSPLHMAAQGDHVECVKHLLQHKAPV 358
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
+ T Y T H+AA GH + L+ AN N G TP+H A + ++ + L
Sbjct: 359 DDVTLDYL-TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELL 417
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNLQN 182
V GA + SGLT +A G LL LQN
Sbjct: 418 VKYGASIQAITESGLTPIHVAAFMGHLNIV--LLLLQN 453
Score = 52.8 bits (125), Expect = 6e-07
Identities = 50/183 (27%), Positives = 87/183 (47%), Gaps = 11/183 (6%)
Query: 26 LHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATLN 85
LH A ++G + + LL + A++ G T +H A+ G+ E + LV+ GA +N
Sbjct: 68 LHLAAKEGHVGLVQELLGRGSSVDSATKK---GNTALHIASLAGQAEVVKVLVKEGANIN 124
Query: 86 VSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALV 145
+ TP ++AA H + +L++ GAN + +G TP+ A + G + ++ L+
Sbjct: 125 AQSQN-GFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL 183
Query: 146 ANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNLQNCHLNHFYNNGILNGGHQNVF-PN 204
N D + L A IA + + A L LQN H + ++N ++ F P
Sbjct: 184 EN----DTKGKVRLPALHIAARKDDTKSAALL--LQNDHNADVQSKMMVNRTTESGFTPL 237
Query: 205 HIS 207
HI+
Sbjct: 238 HIA 240
Score = 51.2 bits (121), Expect = 2e-06
Identities = 37/121 (30%), Positives = 59/121 (48%), Gaps = 8/121 (6%)
Query: 26 LHRACRDGDLATLCSLLQQTPHAHLASEDSF--YGWTPVHWAAHFGKLECLVQLVRAGAT 83
LH A ++ D + +L + H A +D+ G+TP+ A H+G ++ + L++ GA
Sbjct: 699 LHLAAQE-DKVNVADILTK----HGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGAN 753
Query: 84 LNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISA 143
+N T + TP H AA GH + L+Q GA N G T + A R G + +
Sbjct: 754 VNAKT-KNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDT 812
Query: 144 L 144
L
Sbjct: 813 L 813
Score = 47.8 bits (112), Expect = 2e-05
Identities = 44/164 (26%), Positives = 72/164 (43%), Gaps = 18/164 (10%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PL+ A ++ + + LL+ + A+ED G+TP+ A G + + L L
Sbjct: 133 PLYMAAQENHIDVVKYLLENGANQSTATED---GFTPLAVALQQGHNQAVAIL------L 183
Query: 85 NVSTTRYAQTPA-HIAAFGGHPQCLVWLIQAGAN--------INKPDCEGETPIHKAARS 135
T + PA HIAA + L+Q N +N+ G TP+H AA
Sbjct: 184 ENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHY 243
Query: 136 GSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLLN 179
G++ + L+ GA VD +G+T +A +G + LL+
Sbjct: 244 GNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLD 287
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 78.2 bits (191), Expect = 1e-14
Identities = 52/170 (30%), Positives = 79/170 (46%), Gaps = 6/170 (3%)
Query: 12 AGFSSEELLSLRFPLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKL 71
+GF + + + PLH A +G L LLQ + E G T + AA G
Sbjct: 532 SGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEK---GRTALDLAAFKGHT 588
Query: 72 ECLVQLVRAGATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGAN---INKPDCEGETP 128
EC+ L+ GA++ V +TP H + GH CL L++ N ++ D +G+TP
Sbjct: 589 ECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTP 648
Query: 129 IHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
+ A G ++ +S L+ A+VD + G TA G +EC Q LL
Sbjct: 649 LMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLL 698
Score = 69.7 bits (169), Expect = 5e-12
Identities = 45/154 (29%), Positives = 67/154 (43%), Gaps = 4/154 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH G +L+Q +D G TP+H AA +G E L+ +R
Sbjct: 284 PLHMTAVHGRFTRSQTLIQNGGEIDCVDKD---GNTPLHVAARYGH-ELLINTLRTSGAD 339
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
++ P H+AA H C L+ +G I+ PD G T +H AA G++ECI L
Sbjct: 340 TAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLL 399
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
++GA ++ G T A C + L+
Sbjct: 400 QSSGADFHKKDKCGRTPLHYAAANCHFHCIETLV 433
Score = 67.8 bits (164), Expect = 2e-11
Identities = 45/149 (30%), Positives = 77/149 (51%), Gaps = 7/149 (4%)
Query: 36 ATLCS--LLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLV-RAGATLNVSTTRYA 92
ATLC LLQ + + ++ G+ +H+AA +G +CL L+ R + S +
Sbjct: 486 ATLCLEFLLQNDANPSIRDKE---GYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGAT 542
Query: 93 QTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVD 152
++P H+AA+ GH Q L L+Q+ +++ D +G T + AA G EC+ AL+ GA +
Sbjct: 543 KSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIF 602
Query: 153 LR-NASGLTAADIAQTQGFQECAQFLLNL 180
++ N + T + G C + LL +
Sbjct: 603 VKDNVTKRTPLHASVINGHTLCLRLLLEI 631
Score = 65.9 bits (159), Expect = 7e-11
Identities = 47/157 (29%), Positives = 77/157 (49%), Gaps = 6/157 (3%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGW-TPVHWAAHFGKLECLVQLVRAGAT 83
PLHRA + L++ + + ++ W TP+H AA ++C ++ ++
Sbjct: 52 PLHRAVASRSEEAVQVLIKHSADVNARDKN----WQTPLHVAAANKAVKCAEVIIPLLSS 107
Query: 84 LNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISA 143
+NVS R +T H AA GH + + L+ GANIN D + +H AA G L+ ++
Sbjct: 108 VNVSD-RGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVAL 166
Query: 144 LVANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNL 180
L+ +GA V ++ G T A + G + LLNL
Sbjct: 167 LINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNL 203
Score = 65.5 bits (158), Expect = 9e-11
Identities = 49/163 (30%), Positives = 72/163 (44%), Gaps = 12/163 (7%)
Query: 23 RFPLHRACRDGDLATLCSLLQQTPHAHLASEDSFY----GWTPVHWAAHFGKLECLVQLV 78
R PLH A G L LLQ L+ ED + G+TP+HWA + G C+ L+
Sbjct: 712 RTPLHYAAARGHATWLSELLQMA----LSEEDCCFKDNQGYTPLHWACYNGNENCIEVLL 767
Query: 79 RAGATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQA--GANINKPDCEGETPIHKAARSG 136
+ TP H A H C L+ A + ++ D +G TP+ AA +
Sbjct: 768 EQKCFRKFIGNPF--TPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFAD 825
Query: 137 SLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLLN 179
+EC+ L+ + A V+ + SG TA +A G L+N
Sbjct: 826 HVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVN 868
Score = 64.7 bits (156), Expect = 2e-10
Identities = 46/141 (32%), Positives = 73/141 (51%), Gaps = 4/141 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A R G + +L +T A A + + P+H AA +C +L+ +G +
Sbjct: 317 PLHVAARYGHELLINTL--RTSGADTA-KCGIHSMFPLHLAALNAHSDCCRKLLSSGFEI 373
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
+ + ++ +T H AA GG+ +C+ L +GA+ +K D G TP+H AA + CI L
Sbjct: 374 D-TPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETL 432
Query: 145 VANGAHVDLRNASGLTAADIA 165
V GA+V+ + G TA A
Sbjct: 433 VTTGANVNETDDWGRTALHYA 453
Score = 62.8 bits (151), Expect = 6e-10
Identities = 53/187 (28%), Positives = 77/187 (41%), Gaps = 32/187 (17%)
Query: 24 FPLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGAT 83
FPLH A + LL + + D F G T +H AA G +EC+ L +GA
Sbjct: 349 FPLHLAALNAHSDCCRKLLSSG--FEIDTPDKF-GRTCLHAAAAGGNVECIKLLQSSGAD 405
Query: 84 LNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAA---------- 133
+ + +TP H AA H C+ L+ GAN+N+ D G T +H AA
Sbjct: 406 FH-KKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTI 464
Query: 134 ------RSGSLE------------CISALVANGAHVDLRNASGLTAADIAQTQGFQECAQ 175
S LE C+ L+ N A+ +R+ G + A G ++C +
Sbjct: 465 LGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLE 524
Query: 176 FLLNLQN 182
LL N
Sbjct: 525 LLLERTN 531
Score = 62.0 bits (149), Expect = 1e-09
Identities = 56/184 (30%), Positives = 80/184 (43%), Gaps = 14/184 (7%)
Query: 58 GWTPVHWAAHFGKLECLVQLVRAGATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGAN 117
G T +H AA G +E + L+ GA +N + + H AA+ GH + LI GA
Sbjct: 115 GRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRA-LHWAAYMGHLDVVALLINHGAE 173
Query: 118 INKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFL 177
+ D +G TP+H AA +G + + L+ G +D N G TA IA G L
Sbjct: 174 VTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNEL 233
Query: 178 LNLQNCHLNHFYNNGILNGGHQNVFPNHI-SVGTNRKRCLEDSEDFGVKKARTEAQSLDS 236
++ ++N NNG P H + T+ CLE + G A QS D
Sbjct: 234 ID-YGANVNQPNNNGFT--------PLHFAAASTHGALCLELLVNNG---ADVNIQSKDG 281
Query: 237 AVPL 240
PL
Sbjct: 282 KSPL 285
Score = 60.8 bits (146), Expect = 2e-09
Identities = 48/156 (30%), Positives = 75/156 (48%), Gaps = 7/156 (4%)
Query: 26 LHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAH--FGKLECLVQLVRAGAT 83
LH AC +G A + L+ + + + + G+TP+H+AA G L CL LV GA
Sbjct: 218 LHIACYNGQDAVVNELIDYGANVNQPNNN---GFTPLHFAAASTHGAL-CLELLVNNGAD 273
Query: 84 LNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISA 143
+N+ + + ++P H+ A G LIQ G I+ D +G TP+H AAR G I+
Sbjct: 274 VNIQS-KDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINT 332
Query: 144 LVANGAHVDLRNASGLTAADIAQTQGFQECAQFLLN 179
L +GA + +A +C + LL+
Sbjct: 333 LRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLS 368
Score = 57.8 bits (138), Expect = 2e-08
Identities = 37/129 (28%), Positives = 63/129 (48%), Gaps = 2/129 (1%)
Query: 60 TPVHWAAHFGKLECLVQLVRAGATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANIN 119
TP+H AA G E + L+ +GA +N + TP H A + + LI+ A++N
Sbjct: 18 TPLHVAAFLGDAEIIELLILSGARVNAKDNMWL-TPLHRAVASRSEEAVQVLIKHSADVN 76
Query: 120 KPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLLN 179
D +TP+H AA + +++C ++ + V++ + G TA A G E LL
Sbjct: 77 ARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLL- 135
Query: 180 LQNCHLNHF 188
+ ++N F
Sbjct: 136 AKGANINAF 144
Score = 55.8 bits (133), Expect = 7e-08
Identities = 29/88 (32%), Positives = 48/88 (54%)
Query: 93 QTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVD 152
+TP H+AAF G + + LI +GA +N D TP+H+A S S E + L+ + A V+
Sbjct: 17 RTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVN 76
Query: 153 LRNASGLTAADIAQTQGFQECAQFLLNL 180
R+ + T +A +CA+ ++ L
Sbjct: 77 ARDKNWQTPLHVAAANKAVKCAEVIIPL 104
Score = 39.7 bits (91), Expect = 0.005
Identities = 29/108 (26%), Positives = 46/108 (42%), Gaps = 11/108 (10%)
Query: 111 LIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGF 170
LI ++N D E TP+H AA G E I L+ +GA V+ ++ LT A
Sbjct: 2 LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRS 61
Query: 171 QECAQFLLNLQNCHLNHFYNNGILNGGHQN-VFPNHISVGTNRKRCLE 217
+E Q L+ ++ +N +N P H++ +C E
Sbjct: 62 EEAVQVLIK----------HSADVNARDKNWQTPLHVAAANKAVKCAE 99
>gi|155969701 espin-like [Homo sapiens]
Length = 1005
Score = 78.2 bits (191), Expect = 1e-14
Identities = 54/154 (35%), Positives = 77/154 (50%), Gaps = 5/154 (3%)
Query: 25 PLHRACRDGDLATLCSLLQQT-PHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGAT 83
PL+ AC++G L L++ HL + D G + +H AA G +V LV
Sbjct: 174 PLYLACQEGHLHLAQFLVKDCGADVHLRALD---GMSALHAAAARGHYSLVVWLVTFTDI 230
Query: 84 LNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISA 143
+ T H AA GGH L L+ G I + D G TP+H AA +G +EC
Sbjct: 231 GLTARDNEGATALHFAARGGHTPILDRLLLMGTPILR-DSWGGTPLHDAAENGQMECCQT 289
Query: 144 LVANGAHVDLRNASGLTAADIAQTQGFQECAQFL 177
LV++ LR+ G TAAD+A+ G ++CAQ+L
Sbjct: 290 LVSHHVDPSLRDEDGYTAADLAEYHGHRDCAQYL 323
Score = 74.7 bits (182), Expect = 1e-13
Identities = 53/154 (34%), Positives = 74/154 (48%), Gaps = 3/154 (1%)
Query: 26 LHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATLN 85
+H A R G L + L+Q+ ++ + G TP H AA G L L LVR G
Sbjct: 40 VHHATRAGHLDCVKFLVQRAQLP--GNQRAHNGATPAHDAAATGSLAELCWLVREGGCGL 97
Query: 86 VSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL- 144
+P H+AA GHP + WL+ G + EG P+H AA SG L C+ L
Sbjct: 98 QDQDASGVSPLHLAARFGHPVLVEWLLHEGHSATLETREGARPLHHAAVSGDLTCLKLLT 157
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
A+G+ V+ R SG + +A +G AQFL+
Sbjct: 158 AAHGSSVNRRTRSGASPLYLACQEGHLHLAQFLV 191
Score = 68.2 bits (165), Expect = 1e-11
Identities = 58/194 (29%), Positives = 87/194 (44%), Gaps = 11/194 (5%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
P H A G LA LC L+++ L +D+ G +P+H AA FG + L+ G +
Sbjct: 73 PAHDAAATGSLAELCWLVRE-GGCGLQDQDA-SGVSPLHLAARFGHPVLVEWLLHEGHSA 130
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQA-GANINKPDCEGETPIHKAARSGSLECISA 143
+ TR P H AA G CL L A G+++N+ G +P++ A + G L
Sbjct: 131 TLE-TREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQEGHLHLAQF 189
Query: 144 LVAN-GAHVDLRNASGLTAADIAQTQGFQECAQFLLNLQNCHLNHFYNNG------ILNG 196
LV + GA V LR G++A A +G +L+ + L N G G
Sbjct: 190 LVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIGLTARDNEGATALHFAARG 249
Query: 197 GHQNVFPNHISVGT 210
GH + + +GT
Sbjct: 250 GHTPILDRLLLMGT 263
Score = 57.8 bits (138), Expect = 2e-08
Identities = 47/165 (28%), Positives = 65/165 (39%), Gaps = 3/165 (1%)
Query: 29 ACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATLNVST 88
A +DGD+ATL LL+ ++ G VH A G L+C+ LV+
Sbjct: 9 AAKDGDVATLERLLEAGALGPGITDALGAGL--VHHATRAGHLDCVKFLVQRAQLPGNQR 66
Query: 89 TRYAQTPAHIAAFGGHPQCLVWLI-QAGANINKPDCEGETPIHKAARSGSLECISALVAN 147
TPAH AA G L WL+ + G + D G +P+H AAR G + L+
Sbjct: 67 AHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHE 126
Query: 148 GAHVDLRNASGLTAADIAQTQGFQECAQFLLNLQNCHLNHFYNNG 192
G L G A G C + L +N +G
Sbjct: 127 GHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSG 171
>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
sapiens]
Length = 1771
Score = 77.0 bits (188), Expect = 3e-14
Identities = 54/158 (34%), Positives = 77/158 (48%), Gaps = 6/158 (3%)
Query: 58 GWTPVHWAAHFGKLECLVQLVRAGATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGAN 117
GWT + WA + G+ + + L+ GA +V T Y+ P AA GH + L+Q GA
Sbjct: 104 GWTALMWACYKGRTDVVELLLSHGANPSV-TGLYSVYPIIWAAGRGHADIVHLLLQNGAK 162
Query: 118 INKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGF-QECAQF 176
+N D G TP+ AAR G LEC+ L+A GA VD A+ +TA +A G+ Q +
Sbjct: 163 VNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEI 222
Query: 177 LLNLQNCHLNHFYNNGIL----NGGHQNVFPNHISVGT 210
L N +L N L GH + + + GT
Sbjct: 223 LKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGT 260
Score = 61.6 bits (148), Expect = 1e-09
Identities = 38/122 (31%), Positives = 62/122 (50%), Gaps = 1/122 (0%)
Query: 57 YGWTPVHWAAHFGKLECLVQLVRAGATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGA 116
YG TP+ WAA G LEC+ L+ GA ++ + T +A GG+ Q + +++
Sbjct: 169 YGTTPLVWAARKGHLECVKHLLAMGADVDQEGAN-SMTALIVAVKGGYTQSVKEILKRNP 227
Query: 117 NINKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQF 176
N+N D +G T + A++ G E + L+ G +V++ + SG T A G E +
Sbjct: 228 NVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRA 287
Query: 177 LL 178
LL
Sbjct: 288 LL 289
Score = 43.5 bits (101), Expect = 4e-04
Identities = 27/87 (31%), Positives = 46/87 (52%)
Query: 93 QTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVD 152
QTP IAA G+ + + LI+ GAN N D + T + A++ G + + L+ G +++
Sbjct: 39 QTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLE 98
Query: 153 LRNASGLTAADIAQTQGFQECAQFLLN 179
R+ G TA A +G + + LL+
Sbjct: 99 HRDMGGWTALMWACYKGRTDVVELLLS 125
Score = 41.2 bits (95), Expect = 0.002
Identities = 46/183 (25%), Positives = 76/183 (41%), Gaps = 37/183 (20%)
Query: 29 ACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATLNVST 88
A + G ++ +L++ P+ +L +D G T + A+ G E + L+ AG +N+
Sbjct: 210 AVKGGYTQSVKEILKRNPNVNLTDKD---GNTALMIASKEGHTEIVQDLLDAGTYVNIPD 266
Query: 89 TRYAQTPAHIAAFGGHPQCLVWLIQAGANIN----------------------------K 120
R T A GGH + + L+Q A+I+
Sbjct: 267 -RSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCN 325
Query: 121 PDCE-----GETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQ 175
PD E GETP+ KA + ++E + L+ GA V + G T IA ++ A+
Sbjct: 326 PDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAE 385
Query: 176 FLL 178
LL
Sbjct: 386 LLL 388
Score = 40.4 bits (93), Expect = 0.003
Identities = 31/121 (25%), Positives = 53/121 (43%), Gaps = 1/121 (0%)
Query: 58 GWTPVHWAAHFGKLECLVQLVRAGATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGAN 117
G TP+ AA G LE + +L++ GA N+ T A+ GH + L++ G N
Sbjct: 38 GQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDN-WTALISASKEGHVHIVEELLKCGVN 96
Query: 118 INKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFL 177
+ D G T + A G + + L+++GA+ + + A +G + L
Sbjct: 97 LEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLL 156
Query: 178 L 178
L
Sbjct: 157 L 157
Score = 38.5 bits (88), Expect = 0.012
Identities = 28/119 (23%), Positives = 55/119 (46%), Gaps = 4/119 (3%)
Query: 29 ACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATLNVST 88
A R G + + +LLQ+ + +D+ T ++WA G + +++ + T
Sbjct: 276 AVRGGHVEIVRALLQKYADIDIRGQDNK---TALYWAVEKGNATMVRDILQCNPDTEICT 332
Query: 89 TRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVAN 147
+ +TP A + + + L+ GA ++ D +G+TP+H A R S + L+ N
Sbjct: 333 -KDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRN 390
>gi|116875852 HECT domain and ankyrin repeat containing, E3
ubiquitin protein ligase 1 [Homo sapiens]
Length = 909
Score = 76.6 bits (187), Expect = 4e-14
Identities = 46/154 (29%), Positives = 78/154 (50%), Gaps = 5/154 (3%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A R+G + LL+ + ++ + + G T +HW A G+ E L LV+ + +
Sbjct: 101 PLHLAARNGQKKCMSKLLEYSADVNICNNE---GLTAIHWLAVNGRTELLHDLVQHVSDV 157
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
+V QT H+A GH + L+ +GA+IN+P+ G TP++ A G + L
Sbjct: 158 DVEDAM-GQTALHVACQNGHKTTVQCLLDSGADINRPNVSGATPLYFACSHGQRDTAQIL 216
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
+ GA L + +G+T D+ G+ E + L+
Sbjct: 217 LLRGAKY-LPDKNGVTPLDLCVQGGYGETCEVLI 249
Score = 69.7 bits (169), Expect = 5e-12
Identities = 43/118 (36%), Positives = 65/118 (55%), Gaps = 1/118 (0%)
Query: 62 VHWAAHFGKLECLVQLVRAGATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKP 121
+H AA+ G +ECLV L++ GA N TP H+AA G +C+ L++ A++N
Sbjct: 69 LHIAANCGSVECLVLLLKKGANPNYQDISGC-TPLHLAARNGQKKCMSKLLEYSADVNIC 127
Query: 122 DCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLLN 179
+ EG T IH A +G E + LV + + VD+ +A G TA +A G + Q LL+
Sbjct: 128 NNEGLTAIHWLAVNGRTELLHDLVQHVSDVDVEDAMGQTALHVACQNGHKTTVQCLLD 185
Score = 66.6 bits (161), Expect = 4e-11
Identities = 44/153 (28%), Positives = 75/153 (49%), Gaps = 4/153 (2%)
Query: 26 LHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATLN 85
LH A G + L LL++ + + G TP+H AA G+ +C+ +L+ A +N
Sbjct: 69 LHIAANCGSVECLVLLLKKGANPNY---QDISGCTPLHLAARNGQKKCMSKLLEYSADVN 125
Query: 86 VSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALV 145
+ T H A G + L L+Q ++++ D G+T +H A ++G + L+
Sbjct: 126 ICNNE-GLTAIHWLAVNGRTELLHDLVQHVSDVDVEDAMGQTALHVACQNGHKTTVQCLL 184
Query: 146 ANGAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
+GA ++ N SG T A + G ++ AQ LL
Sbjct: 185 DSGADINRPNVSGATPLYFACSHGQRDTAQILL 217
Score = 62.8 bits (151), Expect = 6e-10
Identities = 34/78 (43%), Positives = 48/78 (61%)
Query: 84 LNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISA 143
+N + R ++ HIAA G +CLV L++ GAN N D G TP+H AAR+G +C+S
Sbjct: 57 VNYAFGRVKRSLLHIAANCGSVECLVLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSK 116
Query: 144 LVANGAHVDLRNASGLTA 161
L+ A V++ N GLTA
Sbjct: 117 LLEYSADVNICNNEGLTA 134
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 76.3 bits (186), Expect = 5e-14
Identities = 72/234 (30%), Positives = 103/234 (44%), Gaps = 25/234 (10%)
Query: 58 GWTPVHWAAHFGKLECLVQLVRAGATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGAN 117
G + +H A H G LE + L+ GA+LNV + Q P H AAF GH + L L+ GA+
Sbjct: 140 GRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQ-PLHWAAFLGHLEVLKLLVARGAD 198
Query: 118 INKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFL 177
+ D +G +H AA SG +E + L+ GA +D NA G TA IA G A L
Sbjct: 199 LGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIEL 258
Query: 178 LNLQNCHLNHFYNNGILNGGHQNVFPNHI-SVGTNRKRCLEDSEDFG------------- 223
+N ++N + G P H+ +V TN CLE + G
Sbjct: 259 VN-AGANVNQPNDKGFT--------PLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSP 309
Query: 224 VKKARTEAQSLDSAVPLTNGDTEDDADKMHVDREFAVVTDMKNSSSVSNTLTNG 277
+ A + S + + NG D ADK + V + +S +TNG
Sbjct: 310 LHMAAIHGRFTRSQILIQNGSEIDCADKFG-NTPLHVAARYGHELLISTLMTNG 362
Score = 75.9 bits (185), Expect = 7e-14
Identities = 65/205 (31%), Positives = 88/205 (42%), Gaps = 47/205 (22%)
Query: 24 FPLHRA--------CR----DGDLATLCSLLQQTPHAHLASED----SFYGWTPVHWAAH 67
FPLH A CR G L ++ S L H A D G T +H AA
Sbjct: 374 FPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNE-HVLSAGFDINTPDNLGRTCLHAAAS 432
Query: 68 FGKLECLVQLVRAGATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGET 127
G +ECL L+ +GA L ++ +TP H AA G QC V L+ AGA +N+ DC+G +
Sbjct: 433 GGNVECLNLLLSSGADLR-RRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCS 491
Query: 128 PIHKAARSGSLE----------------------------CISALVANGAHVDLRNASGL 159
P+H AA S + C+ L+ NGA LR+ G
Sbjct: 492 PLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGY 551
Query: 160 TAADIAQTQGFQECAQFLLNLQ-NC 183
TA A G ++ + LL + NC
Sbjct: 552 TAVHYAAAYGNRQNLELLLEMSFNC 576
Score = 69.7 bits (169), Expect = 5e-12
Identities = 47/161 (29%), Positives = 76/161 (47%), Gaps = 7/161 (4%)
Query: 59 WTPVHWAAHFGKLECLVQLVRAGATLNVSTTR--YAQTPAHIAAFGGHPQCLVWLIQAGA 116
WTP+H AA G + L L+ +G +++ Y QTP +A GH C+ L++ G+
Sbjct: 653 WTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGS 712
Query: 117 NINKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQF 176
+ D G T +H+ A +G +C++AL+ + A V R+ G T +A G +
Sbjct: 713 TADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRT 772
Query: 177 LLNLQNCHLNHFYNNGILNGGHQNVFPNHISVGTNRKRCLE 217
L LQ + G+ G+ P H + T + CLE
Sbjct: 773 L--LQAALSTDPLDAGVDYSGYS---PMHWASYTGHEDCLE 808
Score = 67.4 bits (163), Expect = 2e-11
Identities = 58/185 (31%), Positives = 88/185 (47%), Gaps = 9/185 (4%)
Query: 26 LHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHF--GKLECLVQLVRAGAT 83
LH AC G A L+ + + ++ G+TP+H AA G L CL LV GA
Sbjct: 243 LHIACYLGQDAVAIELVNAGANVNQPNDK---GFTPLHVAAVSTNGAL-CLELLVNNGAD 298
Query: 84 LNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISA 143
+N + + ++P H+AA G LIQ G+ I+ D G TP+H AAR G IS
Sbjct: 299 VNYQS-KEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLIST 357
Query: 144 LVANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNLQNCH--LNHFYNNGILNGGHQNV 201
L+ NGA R + +A GF +C + LL+ + ++ N +L+ G
Sbjct: 358 LMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDIN 417
Query: 202 FPNHI 206
P+++
Sbjct: 418 TPDNL 422
Score = 66.6 bits (161), Expect = 4e-11
Identities = 59/228 (25%), Positives = 97/228 (42%), Gaps = 17/228 (7%)
Query: 23 RFPLHRACRDGDLATLCSLLQQTPHAH-LASEDSFYGWTPVHWAAHFGKLECLVQLVRAG 81
R P+H A G A L +LLQ L + + G++P+HWA++ G +CL L+
Sbjct: 755 RTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHS 814
Query: 82 ATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQA-GANI-NKPDCEGETPIHKAARSGSLE 139
+ + TP H A L+ A GA I N D +G TP+H AA + ++
Sbjct: 815 PFSYLEGNPF--TPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVS 872
Query: 140 CISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNLQNCHLNHFYNNGILNGGHQ 199
+ L+ + A V+ + +G TA A G +FLL L +L+
Sbjct: 873 GLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLT------VLDENKN 926
Query: 200 NVFPNHISVGTNRKRC----LEDSEDFGVKKARTEAQSLDSAVPLTNG 243
H++ ++C L +++D G+ A A + + NG
Sbjct: 927 TAL--HLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNG 972
Score = 64.3 bits (155), Expect = 2e-10
Identities = 47/155 (30%), Positives = 78/155 (50%), Gaps = 4/155 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PL +A D+ + SLL Q + ++ ++ TP+H AA+ G + L L+ +GA +
Sbjct: 11 PLVQAIFSRDVEEVRSLLSQKENINVLDQERR---TPLHAAAYVGDVPILQLLLMSGANV 67
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
N T + TP H AA + + L L+ A++N D +TP+H AA + + +C AL
Sbjct: 68 NAKDTLWL-TPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEAL 126
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLLN 179
+ +++ + SG +A A G E LLN
Sbjct: 127 APLLSSLNVADRSGRSALHHAVHSGHLETVNLLLN 161
Score = 64.3 bits (155), Expect = 2e-10
Identities = 52/188 (27%), Positives = 78/188 (41%), Gaps = 25/188 (13%)
Query: 9 GVEAGFSSEELLSLRFPLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHF 68
G + + S+E S PLH A G L+Q A + +G TP+H AA +
Sbjct: 296 GADVNYQSKEGKS---PLHMAAIHGRFTRSQILIQNGSEIDCADK---FGNTPLHVAARY 349
Query: 69 GKLECLVQLVRAGATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQ--------------- 113
G E L+ + + P H+A G C L+
Sbjct: 350 GH-ELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEH 408
Query: 114 ---AGANINKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGF 170
AG +IN PD G T +H AA G++EC++ L+++GA + R+ G T A G
Sbjct: 409 VLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGS 468
Query: 171 QECAQFLL 178
+CA L+
Sbjct: 469 YQCAVTLV 476
Score = 63.2 bits (152), Expect = 4e-10
Identities = 45/152 (29%), Positives = 70/152 (46%), Gaps = 22/152 (14%)
Query: 25 PLHRACRDGDLATLCSLLQQ-TPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGAT 83
PLH A R G + +L+ A D F P+H A FG +C +L+ +G
Sbjct: 342 PLHVAARYGHELLISTLMTNGADTARRGIHDMF----PLHLAVLFGFSDCCRKLLSSGQL 397
Query: 84 LNVSTT-----------------RYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGE 126
++ ++ +T H AA GG+ +CL L+ +GA++ + D G
Sbjct: 398 YSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGR 457
Query: 127 TPIHKAARSGSLECISALVANGAHVDLRNASG 158
TP+H AA +GS +C LV GA V+ + G
Sbjct: 458 TPLHYAAANGSYQCAVTLVTAGAGVNEADCKG 489
Score = 63.2 bits (152), Expect = 4e-10
Identities = 44/158 (27%), Positives = 68/158 (43%), Gaps = 6/158 (3%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A +G L +L + + + G T + A G EC+ L GA+
Sbjct: 588 PLHLAAYNGHCEALKTLAETLVNLDVRDHK---GRTALFLATERGSTECVEVLTAHGASA 644
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGAN---INKPDCEGETPIHKAARSGSLECI 141
+ + TP H AA GH L LI +G + D G+TP+ A +G ++C+
Sbjct: 645 LIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCV 704
Query: 142 SALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLLN 179
L+ G+ D + G TA G ++C LL+
Sbjct: 705 HLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLD 742
Score = 62.0 bits (149), Expect = 1e-09
Identities = 48/156 (30%), Positives = 74/156 (47%), Gaps = 4/156 (2%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLHRA + L LL + A + + D + TP+H AA +C L ++L
Sbjct: 77 PLHRAAASRNEKVLGLLLAHS--ADVNARDKLWQ-TPLHVAAANRATKCAEALAPLLSSL 133
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
NV+ R ++ H A GH + + L+ GA++N D + P+H AA G LE + L
Sbjct: 134 NVAD-RSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLL 192
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNL 180
VA GA + ++ G A G E ++LL +
Sbjct: 193 VARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRM 228
Score = 54.7 bits (130), Expect = 2e-07
Identities = 31/93 (33%), Positives = 48/93 (51%), Gaps = 1/93 (1%)
Query: 58 GWTPVHWAAHFGKLECLVQLVRAGAT-LNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGA 116
G+T VH+AA +G + L L+ L + +P H+AA+ GH + L L +
Sbjct: 550 GYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLV 609
Query: 117 NINKPDCEGETPIHKAARSGSLECISALVANGA 149
N++ D +G T + A GS EC+ L A+GA
Sbjct: 610 NLDVRDHKGRTALFLATERGSTECVEVLTAHGA 642
Score = 52.8 bits (125), Expect = 6e-07
Identities = 30/88 (34%), Positives = 47/88 (53%)
Query: 93 QTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVD 152
+TP H AA+ G L L+ +GAN+N D TP+H+AA S + + + L+A+ A V+
Sbjct: 42 RTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVN 101
Query: 153 LRNASGLTAADIAQTQGFQECAQFLLNL 180
R+ T +A +CA+ L L
Sbjct: 102 ARDKLWQTPLHVAAANRATKCAEALAPL 129
Score = 47.0 bits (110), Expect = 3e-05
Identities = 41/136 (30%), Positives = 62/136 (45%), Gaps = 10/136 (7%)
Query: 45 TPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATLNVSTTRYAQTPAHIAAFGGH 104
TP +H A ED P+ + CL L+ GA ++ R T H AA G+
Sbjct: 509 TPSSHDAEEDE-----PLKESRRKEAFFCLEFLLDNGADPSLRD-RQGYTAVHYAAAYGN 562
Query: 105 PQCLVWLIQAGANINKPDCEGE---TPIHKAARSGSLECISALVANGAHVDLRNASGLTA 161
Q L L++ N + D E +P+H AA +G E + L ++D+R+ G TA
Sbjct: 563 RQNLELLLEMSFNCLE-DVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTA 621
Query: 162 ADIAQTQGFQECAQFL 177
+A +G EC + L
Sbjct: 622 LFLATERGSTECVEVL 637
Score = 45.4 bits (106), Expect = 9e-05
Identities = 42/161 (26%), Positives = 69/161 (42%), Gaps = 7/161 (4%)
Query: 23 RFPLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGA 82
R PLH A +++ L LLQ H + G T + AA G+ + L+ G
Sbjct: 859 RTPLHAAAFADNVSGLRMLLQ---HQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGK 915
Query: 83 TLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGAN---INKPDCEGETPIHKAARSGSLE 139
T H+A GH +C + ++ + IN + + P+H AAR+G
Sbjct: 916 ADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLAS 975
Query: 140 CISALVANGAHVDLRNASGLT-AADIAQTQGFQECAQFLLN 179
+ AL+++GA V + G T A A + +C +L+
Sbjct: 976 VVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLALILS 1016
Score = 35.0 bits (79), Expect = 0.13
Identities = 22/68 (32%), Positives = 34/68 (50%)
Query: 93 QTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVD 152
Q P A F + + L+ NIN D E TP+H AA G + + L+ +GA+V+
Sbjct: 9 QPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVN 68
Query: 153 LRNASGLT 160
++ LT
Sbjct: 69 AKDTLWLT 76
>gi|18252778 ankyrin repeat and SOCS box-containing protein 2 [Homo
sapiens]
Length = 587
Score = 75.5 bits (184), Expect = 9e-14
Identities = 48/155 (30%), Positives = 81/155 (52%), Gaps = 3/155 (1%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PL +A +DGD L +++++ + +E + GW P+H AA++G++ CL L RA
Sbjct: 60 PLIKAIKDGDEEALKTMIKEGKNL---AEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGT 116
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
T +T ++A GH CL+ L+QAGA + + ETP++KA + E + L
Sbjct: 117 IDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKIL 176
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLLN 179
V + A + R G TA + ++ E Q L++
Sbjct: 177 VQHNADTNHRCNRGWTALHESVSRNDLEVMQILVS 211
Score = 63.5 bits (153), Expect = 3e-10
Identities = 49/171 (28%), Positives = 78/171 (45%), Gaps = 7/171 (4%)
Query: 8 AGVEAGFSSEELLSLRFPLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAH 67
AG E S++ S PL++AC + + L+Q H + GWT +H +
Sbjct: 146 AGAEPDISNK---SRETPLYKACERKNAEAVKILVQ---HNADTNHRCNRGWTALHESVS 199
Query: 68 FGKLECLVQLVRAGATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGET 127
LE + LV GA + S Y TP +AA G + L +L + GA+IN + +
Sbjct: 200 RNDLEVMQILVSGGAKVE-SKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNAS 258
Query: 128 PIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
+++A ++ E + L++ GA + N GL IA +G Q LL
Sbjct: 259 ALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLL 309
Score = 54.3 bits (129), Expect = 2e-07
Identities = 42/154 (27%), Positives = 77/154 (50%), Gaps = 5/154 (3%)
Query: 26 LHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATLN 85
LH + DL + L+ + A + S+++ YG TP+ AA G+LE L L + GA +N
Sbjct: 194 LHESVSRNDLEVMQILV--SGGAKVESKNA-YGITPLFVAAQSGQLEALRFLAKYGADIN 250
Query: 86 VSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALV 145
+ A + A H + + +L+ GA+ NK + +G P+H A++ G+ + L+
Sbjct: 251 TQASDNASA-LYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLL 309
Query: 146 ANGAHVDLRNASGLTAADIAQTQGFQECAQFLLN 179
+ +R SG++ +A + E + LL+
Sbjct: 310 PVTSRTRIRR-SGVSPLHLAAERNHDEVLEALLS 342
Score = 36.6 bits (83), Expect = 0.044
Identities = 29/113 (25%), Positives = 50/113 (44%), Gaps = 5/113 (4%)
Query: 26 LHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATLN 85
L+ AC++ + LL Q A+ ++D G P+H A+ G + L+ T
Sbjct: 260 LYEACKNEHEEVVEFLLSQGADANKTNKD---GLLPLHIASKKGNYRIVQMLLPV--TSR 314
Query: 86 VSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSL 138
R +P H+AA H + L L+ A ++N P +++ RS +L
Sbjct: 315 TRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSAL 367
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 74.7 bits (182), Expect = 1e-13
Identities = 54/157 (34%), Positives = 83/157 (52%), Gaps = 9/157 (5%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A R G + +L+ T A A +G P+H AA G +C +L+ +G +
Sbjct: 342 PLHIAARYGHELLINTLI--TSGADTAKR-GIHGMFPLHLAALSGFSDCCRKLLSSGFDI 398
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
+ + +T H AA GG+ +CL L+ GA+ NK D G +P+H AA + + +C+ AL
Sbjct: 399 DTPDD-FGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFAL 457
Query: 145 VANGAHV---DLRNASGLTAADIAQTQGFQECAQFLL 178
V +GA V D R + L A + T G +C ++LL
Sbjct: 458 VGSGASVNDLDERGCTPLHYAATSDTDG--KCLEYLL 492
Score = 71.6 bits (174), Expect = 1e-12
Identities = 51/157 (32%), Positives = 77/157 (49%), Gaps = 6/157 (3%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGW-TPVHWAAHFGKLECLVQLVRAGAT 83
PLHRA + LL+ + + ++ W TP+H AA ++C LV +
Sbjct: 77 PLHRAVASCSEEAVQVLLKHSADVNARDKN----WQTPLHIAAANKAVKCAEALVPLLSN 132
Query: 84 LNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISA 143
+NVS R +T H AAF GH + + L+ GANIN D + IH AA G +E +
Sbjct: 133 VNVSD-RAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKL 191
Query: 144 LVANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNL 180
LV++GA V ++ T A + G ++LL+L
Sbjct: 192 LVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDL 228
Score = 70.1 bits (170), Expect = 4e-12
Identities = 47/149 (31%), Positives = 71/149 (47%), Gaps = 4/149 (2%)
Query: 23 RFPLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGA 82
R PL A G + + L+ Q A + +D TP+H AA G ECL L+
Sbjct: 584 RTPLDLAAFKGHVECVDVLINQG--ASILVKDYILKRTPIHAAATNGHSECLRLLIGNAE 641
Query: 83 TLNVSTTR--YAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLEC 140
N + QTP ++ GH C+ L+ GAN++ D G T +H+ A +G EC
Sbjct: 642 PQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEEC 701
Query: 141 ISALVANGAHVDLRNASGLTAADIAQTQG 169
+ AL+ +GA LR++ G T ++ G
Sbjct: 702 VDALLQHGAKCLLRDSRGRTPIHLSAACG 730
Score = 68.9 bits (167), Expect = 8e-12
Identities = 51/159 (32%), Positives = 79/159 (49%), Gaps = 7/159 (4%)
Query: 27 HRACRD--GDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
HR C L L++ + L+ D+ +P+H AA+ G + L LV++ L
Sbjct: 517 HRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDL 576
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPD-CEGETPIHKAARSGSLECISA 143
+V + +TP +AAF GH +C+ LI GA+I D TPIH AA +G EC+
Sbjct: 577 DVRNSS-GRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRL 635
Query: 144 LVANGAH---VDLRNASGLTAADIAQTQGFQECAQFLLN 179
L+ N VD+++ +G T ++ G +C LLN
Sbjct: 636 LIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLN 674
Score = 68.6 bits (166), Expect = 1e-11
Identities = 46/160 (28%), Positives = 72/160 (45%), Gaps = 5/160 (3%)
Query: 23 RFPLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGA 82
R P+H A +G L L+ + G TP+ + G +C+ L+ GA
Sbjct: 618 RTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGA 677
Query: 83 TLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECIS 142
++ ++ +T H A GH +C+ L+Q GA D G TPIH +A G + +
Sbjct: 678 NVDAKD-KWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLG 736
Query: 143 ALVANGAHVDLRNAS----GLTAADIAQTQGFQECAQFLL 178
AL+ + A +D A+ G TA A G + C + LL
Sbjct: 737 ALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLL 776
Score = 68.2 bits (165), Expect = 1e-11
Identities = 50/156 (32%), Positives = 72/156 (46%), Gaps = 5/156 (3%)
Query: 25 PLHRACRDGDLATLCSLLQQT-PHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGAT 83
PLH A A LL ++ S+D G TP+H A G+ ++++GA
Sbjct: 275 PLHFAAASTHGALCLELLVGNGADVNMKSKD---GKTPLHMTALHGRFSRSQTIIQSGAV 331
Query: 84 LNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISA 143
++ + TP HIAA GH + LI +GA+ K G P+H AA SG +C
Sbjct: 332 IDCED-KNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRK 390
Query: 144 LVANGAHVDLRNASGLTAADIAQTQGFQECAQFLLN 179
L+++G +D + G T A G EC LLN
Sbjct: 391 LLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLN 426
Score = 68.2 bits (165), Expect = 1e-11
Identities = 52/192 (27%), Positives = 86/192 (44%), Gaps = 37/192 (19%)
Query: 23 RFPLHRACRDGDLATLCSLLQQTPH--AHLASEDSFYGWTPVHWAAHFGKLECLVQLVRA 80
R P+H + G + L +LLQ A+ A+ D+ +G+T +HWA + G C+ L+
Sbjct: 720 RTPIHLSAACGHIGVLGALLQSAASMDANPATADN-HGYTALHWACYNGHETCVELLLEQ 778
Query: 81 ---------------------------------GATLNVSTTRYAQTPAHIAAFGGHPQC 107
GA++ +T +TP H AAF H +C
Sbjct: 779 EVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVEC 838
Query: 108 LVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVAN-GAHVDLRNASGLTAADIAQ 166
L L+ A +N D G+TP+ AA +G + LV++ A + L++ S TA +A
Sbjct: 839 LQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLAC 898
Query: 167 TQGFQECAQFLL 178
++G + A +L
Sbjct: 899 SKGHETSALLIL 910
Score = 66.2 bits (160), Expect = 5e-11
Identities = 45/148 (30%), Positives = 71/148 (47%), Gaps = 5/148 (3%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A G ++ + LL + E + YG TP+H A + G+ + +L+ GA +
Sbjct: 209 PLHAAASSGMISVVKYLLDLGVDMN---EPNAYGNTPLHVACYNGQDVVVNELIDCGAIV 265
Query: 85 NVSTTRYAQTPAHIAAFGGH-PQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISA 143
N + TP H AA H CL L+ GA++N +G+TP+H A G
Sbjct: 266 NQKNEK-GFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQT 324
Query: 144 LVANGAHVDLRNASGLTAADIAQTQGFQ 171
++ +GA +D + +G T IA G +
Sbjct: 325 IIQSGAVIDCEDKNGNTPLHIAARYGHE 352
Score = 65.1 bits (157), Expect = 1e-10
Identities = 39/113 (34%), Positives = 60/113 (53%), Gaps = 4/113 (3%)
Query: 59 WTPVHWAAHFGKLECLVQLVRAGATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANI 118
+TP+H AA G + + L+ G +N Y TP H+A + G + LI GA +
Sbjct: 207 YTPLHAAASSGMISVVKYLLDLGVDMN-EPNAYGNTPLHVACYNGQDVVVNELIDCGAIV 265
Query: 119 NKPDCEGETPIHKAARS--GSLECISALVANGAHVDLRNASGLTAADIAQTQG 169
N+ + +G TP+H AA S G+L C+ LV NGA V++++ G T + G
Sbjct: 266 NQKNEKGFTPLHFAAASTHGAL-CLELLVGNGADVNMKSKDGKTPLHMTALHG 317
Score = 64.7 bits (156), Expect = 2e-10
Identities = 50/168 (29%), Positives = 80/168 (47%), Gaps = 18/168 (10%)
Query: 25 PLHRACR-DGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGAT 83
PLH A D D L LL+ + + + G+ VH++A +G CL QL+ +
Sbjct: 474 PLHYAATSDTDGKCLEYLLRNDANPGIRDKQ---GYNAVHYSAAYGHRLCL-QLIASETP 529
Query: 84 LNV------------STTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHK 131
L+V S R +P H+AA+ GH Q L L+Q+ +++ + G TP+
Sbjct: 530 LDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDL 589
Query: 132 AARSGSLECISALVANGAHVDLRN-ASGLTAADIAQTQGFQECAQFLL 178
AA G +EC+ L+ GA + +++ T A T G EC + L+
Sbjct: 590 AAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLI 637
Score = 64.3 bits (155), Expect = 2e-10
Identities = 34/104 (32%), Positives = 55/104 (52%), Gaps = 1/104 (0%)
Query: 62 VHWAAHFGKLECLVQLVRAGATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKP 121
+HWAA+ G +E + LV GA + + + TP H AA G + +L+ G ++N+P
Sbjct: 177 IHWAAYMGHIEVVKLLVSHGAEVTCKDKK-SYTPLHAAASSGMISVVKYLLDLGVDMNEP 235
Query: 122 DCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIA 165
+ G TP+H A +G ++ L+ GA V+ +N G T A
Sbjct: 236 NAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFA 279
Score = 63.5 bits (153), Expect = 3e-10
Identities = 39/129 (30%), Positives = 71/129 (55%), Gaps = 2/129 (1%)
Query: 60 TPVHWAAHFGKLECLVQLVRAGATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANIN 119
TP+H AA+ G E + L+ +GA +N +++ TP H A + + L++ A++N
Sbjct: 43 TPLHAAAYLGDAEIIELLILSGARVNAKDSKWL-TPLHRAVASCSEEAVQVLLKHSADVN 101
Query: 120 KPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLLN 179
D +TP+H AA + +++C ALV ++V++ + +G TA A G E + LL+
Sbjct: 102 ARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLS 161
Query: 180 LQNCHLNHF 188
+ ++N F
Sbjct: 162 -RGANINAF 169
Score = 57.0 bits (136), Expect = 3e-08
Identities = 56/200 (28%), Positives = 81/200 (40%), Gaps = 50/200 (25%)
Query: 26 LHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATLN 85
LH A G+L L LL A +D F G +P+H+AA +CL LV +GA++N
Sbjct: 409 LHAAAAGGNLECLNLLLNTG--ADFNKKDKF-GRSPLHYAAANCNYQCLFALVGSGASVN 465
Query: 86 VSTTRYAQTPAHIAAFGGHP-QCLVWLIQAGANINKPDCEGE------------------ 126
R TP H AA +CL +L++ AN D +G
Sbjct: 466 DLDERGC-TPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLI 524
Query: 127 ---------------------------TPIHKAARSGSLECISALVANGAHVDLRNASGL 159
+P+H AA G + + LV + +D+RN+SG
Sbjct: 525 ASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGR 584
Query: 160 TAADIAQTQGFQECAQFLLN 179
T D+A +G EC L+N
Sbjct: 585 TPLDLAAFKGHVECVDVLIN 604
Score = 54.3 bits (129), Expect = 2e-07
Identities = 30/88 (34%), Positives = 48/88 (54%)
Query: 93 QTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVD 152
+TP H AA+ G + + LI +GA +N D + TP+H+A S S E + L+ + A V+
Sbjct: 42 RTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVN 101
Query: 153 LRNASGLTAADIAQTQGFQECAQFLLNL 180
R+ + T IA +CA+ L+ L
Sbjct: 102 ARDKNWQTPLHIAAANKAVKCAEALVPL 129
Score = 52.4 bits (124), Expect = 8e-07
Identities = 35/112 (31%), Positives = 54/112 (48%), Gaps = 1/112 (0%)
Query: 58 GWTPVHWAAHFGKLECLVQLVRAGATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGAN 117
G T +H AA G E + L+ GA +N + + H AA+ GH + + L+ GA
Sbjct: 140 GRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRA-IHWAAYMGHIEVVKLLVSHGAE 198
Query: 118 INKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQG 169
+ D + TP+H AA SG + + L+ G ++ NA G T +A G
Sbjct: 199 VTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNG 250
Score = 46.6 bits (109), Expect = 4e-05
Identities = 44/160 (27%), Positives = 69/160 (43%), Gaps = 7/160 (4%)
Query: 23 RFPLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGA 82
R PLH A + L LL +A + S DS G TP+ AA G+ + LV + +
Sbjct: 824 RTPLHAAAFTDHVECLQLLLSH--NAQVNSVDST-GKTPLMMAAENGQTNTVEMLVSSAS 880
Query: 83 TLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGAN---INKPDCEGETPIHKAARSGSLE 139
T H+A GH + +++ + IN + +TP+H AAR+G
Sbjct: 881 AELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTM 940
Query: 140 CISALVANGAHVDLRNASGLT-AADIAQTQGFQECAQFLL 178
+ L+ GA V + +G T A A + +C +L
Sbjct: 941 VVQELLGKGASVLAVDENGYTPALACAPNKDVADCLALIL 980
Score = 45.4 bits (106), Expect = 9e-05
Identities = 35/120 (29%), Positives = 52/120 (43%), Gaps = 11/120 (9%)
Query: 99 AAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASG 158
A F G P + LI ++N D E TP+H AA G E I L+ +GA V+ +++
Sbjct: 15 AIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKW 74
Query: 159 LTAADIAQTQGFQECAQFLLNLQNCHLNHFYNNGILNGGHQN-VFPNHISVGTNRKRCLE 217
LT A +E Q LL ++ +N +N P HI+ +C E
Sbjct: 75 LTPLHRAVASCSEEAVQVLLK----------HSADVNARDKNWQTPLHIAAANKAVKCAE 124
>gi|22208957 ankyrin repeat and SOCS box-containing protein 13 [Homo
sapiens]
Length = 278
Score = 73.2 bits (178), Expect = 4e-13
Identities = 48/133 (36%), Positives = 74/133 (55%), Gaps = 12/133 (9%)
Query: 60 TPVHWAAHFGKLECLVQLVRAGATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANIN 119
TPVH AA G+ L QL+ +GA +N T + TP H A+ G +C+ L+ AGA ++
Sbjct: 21 TPVHEAAQRGESLQLQQLIESGACVNQVTVD-SITPLHAASLQGQARCVQLLLAAGAQVD 79
Query: 120 KPDCEGETPIHKAARSGSLECISALVANGAHVD--LRNASGLTAADIAQTQGFQECAQFL 177
+ +G TP+ A SGS+EC+ L++ GA V+ L AS L A ++ G EC + L
Sbjct: 80 ARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTASPLHEACMS---GSSECVRLL 136
Query: 178 LNL------QNCH 184
+++ +CH
Sbjct: 137 IDVGANLEAHDCH 149
Score = 68.9 bits (167), Expect = 8e-12
Identities = 46/157 (29%), Positives = 77/157 (49%), Gaps = 5/157 (3%)
Query: 23 RFPLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGA 82
R P+H A + G+ L L++ + + DS TP+H A+ G+ C+ L+ AGA
Sbjct: 20 RTPVHEAAQRGESLQLQQLIESGACVNQVTVDSI---TPLHAASLQGQARCVQLLLAAGA 76
Query: 83 TLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECIS 142
++ TP A G +C+ L+ GA +N P +P+H+A SGS EC+
Sbjct: 77 QVDARNID-GSTPLCDACASGSIECVKLLLSYGAKVNPP-LYTASPLHEACMSGSSECVR 134
Query: 143 ALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLLN 179
L+ GA+++ + T +A + +C + LLN
Sbjct: 135 LLIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLN 171
Score = 65.1 bits (157), Expect = 1e-10
Identities = 42/128 (32%), Positives = 59/128 (46%), Gaps = 5/128 (3%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A G + LL + D G TP+ A G +EC+ L+ GA +
Sbjct: 55 PLHAASLQGQARCVQLLLAAGAQVDARNID---GSTPLCDACASGSIECVKLLLSYGAKV 111
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
N Y +P H A G +C+ LI GAN+ DC TP+H A L+C+ L
Sbjct: 112 NPPL--YTASPLHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVACAREHLDCVKVL 169
Query: 145 VANGAHVD 152
+ GA+V+
Sbjct: 170 LNAGANVN 177
Score = 49.7 bits (117), Expect = 5e-06
Identities = 43/142 (30%), Positives = 67/142 (47%), Gaps = 12/142 (8%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH AC G ++ C L A+L + D +G TP+H A L+C+ L+ AGA
Sbjct: 120 PLHEACMSG--SSECVRLLIDVGANLEAHDCHFG-TPLHVACAREHLDCVKVLLNAGA-- 174
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPI-HKAARSGSLECIS- 142
NV+ + +T H AA + + LI+ G NI D G+ P + + S +C
Sbjct: 175 NVNAAKLHETALHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKPSDYTWSSSAPAKCFEY 234
Query: 143 -----ALVANGAHVDLRNASGL 159
++ V+LR A+G+
Sbjct: 235 YEKTPLTLSQLCRVNLRKATGV 256
>gi|156142199 euchromatic histone-lysine N-methyltransferase 2
isoform b [Homo sapiens]
Length = 1176
Score = 72.8 bits (177), Expect = 6e-13
Identities = 46/139 (33%), Positives = 73/139 (52%), Gaps = 3/139 (2%)
Query: 26 LHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATLN 85
LH A + G+L + SLL T + ++DS GWTP+ WAA +E + L+ GA +
Sbjct: 721 LHHAAKIGNLE-MVSLLLSTGQVDVNAQDSG-GWTPIIWAAEHKHIEVIRMLLTRGADVT 778
Query: 86 VSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALV 145
+ T H A+F G L+ A +++ + G+TP+H AAR +C+ +
Sbjct: 779 L-TDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFL 837
Query: 146 ANGAHVDLRNASGLTAADI 164
+ GA+ +LRN G TA D+
Sbjct: 838 SRGANPELRNKEGDTAWDL 856
Score = 45.1 bits (105), Expect = 1e-04
Identities = 31/94 (32%), Positives = 42/94 (44%)
Query: 93 QTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVD 152
+TP H AA G + L+QAGANIN D + TP+ +A + LE +V G V
Sbjct: 652 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVY 711
Query: 153 LRNASGLTAADIAQTQGFQECAQFLLNLQNCHLN 186
+ G T A G E LL+ +N
Sbjct: 712 SKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVN 745
Score = 43.9 bits (102), Expect = 3e-04
Identities = 50/178 (28%), Positives = 75/178 (42%), Gaps = 7/178 (3%)
Query: 10 VEAGFSSEELLSLRFPLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFG 69
++ F S++ S R PLH A + G + LLQ + + + TP+ A
Sbjct: 640 LDPNFQSDQQ-SKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQR---TPLMEAVVNN 695
Query: 70 KLECLVQLVRAGATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAG-ANINKPDCEGETP 128
LE +V+ G + S T H AA G+ + + L+ G ++N D G TP
Sbjct: 696 HLEVARYMVQRGGCV-YSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTP 754
Query: 129 IHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNLQNCHLN 186
I AA +E I L+ GA V L + A G A+ LLN + C L+
Sbjct: 755 IIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNAR-CDLH 811
Score = 31.2 bits (69), Expect = 1.8
Identities = 19/76 (25%), Positives = 32/76 (42%)
Query: 108 LVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQT 167
L+ L N TP+H AA+ GS+E L+ GA+++ + T A
Sbjct: 634 LMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVV 693
Query: 168 QGFQECAQFLLNLQNC 183
E A++++ C
Sbjct: 694 NNHLEVARYMVQRGGC 709
>gi|156142197 euchromatic histone-lysine N-methyltransferase 2
isoform a [Homo sapiens]
Length = 1210
Score = 72.8 bits (177), Expect = 6e-13
Identities = 46/139 (33%), Positives = 73/139 (52%), Gaps = 3/139 (2%)
Query: 26 LHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATLN 85
LH A + G+L + SLL T + ++DS GWTP+ WAA +E + L+ GA +
Sbjct: 755 LHHAAKIGNLE-MVSLLLSTGQVDVNAQDSG-GWTPIIWAAEHKHIEVIRMLLTRGADVT 812
Query: 86 VSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALV 145
+ T H A+F G L+ A +++ + G+TP+H AAR +C+ +
Sbjct: 813 L-TDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFL 871
Query: 146 ANGAHVDLRNASGLTAADI 164
+ GA+ +LRN G TA D+
Sbjct: 872 SRGANPELRNKEGDTAWDL 890
Score = 45.1 bits (105), Expect = 1e-04
Identities = 31/94 (32%), Positives = 42/94 (44%)
Query: 93 QTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVD 152
+TP H AA G + L+QAGANIN D + TP+ +A + LE +V G V
Sbjct: 686 RTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVY 745
Query: 153 LRNASGLTAADIAQTQGFQECAQFLLNLQNCHLN 186
+ G T A G E LL+ +N
Sbjct: 746 SKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVN 779
Score = 43.9 bits (102), Expect = 3e-04
Identities = 50/178 (28%), Positives = 75/178 (42%), Gaps = 7/178 (3%)
Query: 10 VEAGFSSEELLSLRFPLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFG 69
++ F S++ S R PLH A + G + LLQ + + + TP+ A
Sbjct: 674 LDPNFQSDQQ-SKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQR---TPLMEAVVNN 729
Query: 70 KLECLVQLVRAGATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAG-ANINKPDCEGETP 128
LE +V+ G + S T H AA G+ + + L+ G ++N D G TP
Sbjct: 730 HLEVARYMVQRGGCV-YSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTP 788
Query: 129 IHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNLQNCHLN 186
I AA +E I L+ GA V L + A G A+ LLN + C L+
Sbjct: 789 IIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNAR-CDLH 845
Score = 31.2 bits (69), Expect = 1.8
Identities = 19/76 (25%), Positives = 32/76 (42%)
Query: 108 LVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQT 167
L+ L N TP+H AA+ GS+E L+ GA+++ + T A
Sbjct: 668 LMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVV 727
Query: 168 QGFQECAQFLLNLQNC 183
E A++++ C
Sbjct: 728 NNHLEVARYMVQRGGC 743
>gi|13443014 ankyrin repeat and SOCS box-containing 9 isoform 2
[Homo sapiens]
Length = 262
Score = 72.4 bits (176), Expect = 7e-13
Identities = 63/235 (26%), Positives = 110/235 (46%), Gaps = 18/235 (7%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
P+H A G +L +L+ Q ++ + D +P+H A G L C+ L++ GA +
Sbjct: 39 PMHEAAIHGHQLSLRNLISQGWAVNIITADHV---SPLHEACLGGHLSCVKILLKHGAQV 95
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
N T + TP A G C+ L+Q GA++ +P+ + +PIH+AAR G +EC+++L
Sbjct: 96 NGVTADW-HTPLFNACVSGSWDCVNLLLQHGASV-QPESDLASPIHEAARRGHVECVNSL 153
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNLQNCHLNHFYNNGILNGGHQNVFPN 204
+A G ++D + + T +A + C + LL + +N G P
Sbjct: 154 IAYGGNIDHKISHLGTPLYLACENQQRACVKKLLE----------SGADVNQGKGQDSPL 203
Query: 205 HISVGTNRKRCLEDSEDFGVKKARTEAQSLDSAVPLTNGDTEDDADKMHVDREFA 259
H T + DFG A T+A++ + P+ E ++ ++RE A
Sbjct: 204 HAVARTASEELACLLMDFG---ADTQAKNAEGKRPVELVPPESPLAQLFLEREGA 255
Score = 66.2 bits (160), Expect = 5e-11
Identities = 39/125 (31%), Positives = 63/125 (50%), Gaps = 2/125 (1%)
Query: 54 DSFYGWTPVHWAAHFGKLECLVQLVRAGATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQ 113
D+ W+P+H AA G L L+ G +N+ T + +P H A GGH C+ L++
Sbjct: 32 DAVSDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHV-SPLHEACLGGHLSCVKILLK 90
Query: 114 AGANINKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQEC 173
GA +N + TP+ A SGS +C++ L+ +GA V + + A+ +G EC
Sbjct: 91 HGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDLASPIHEAAR-RGHVEC 149
Query: 174 AQFLL 178
L+
Sbjct: 150 VNSLI 154
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 72.4 bits (176), Expect = 7e-13
Identities = 51/162 (31%), Positives = 82/162 (50%), Gaps = 4/162 (2%)
Query: 4 AGAGAGVEAGFSSEELLSLRFPLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVH 63
AG GA A ++E + L ACR+GD+ + L+ TP + + + TP+H
Sbjct: 7 AGGGAAC-ASAAAEAVEPAARELFEACRNGDVERVKRLV--TPEKVNSRDTAGRKSTPLH 63
Query: 64 WAAHFGKLECLVQLVRAGATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDC 123
+AA FG+ + + L++ GA + P H A GH + + L++ GA+ N D
Sbjct: 64 FAAGFGRKDVVEYLLQNGANVQARDDG-GLIPLHNACSFGHAEVVNLLLRHGADPNARDN 122
Query: 124 EGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIA 165
TP+H+AA G ++ L+ +GA +RN G TA D+A
Sbjct: 123 WNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLA 164
Score = 61.2 bits (147), Expect = 2e-09
Identities = 37/105 (35%), Positives = 54/105 (51%), Gaps = 1/105 (0%)
Query: 60 TPVHWAAHFGKLECLVQLVRAGATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANIN 119
TP+H AA + LE L++ GA +N + P H AA GH LI+ A +N
Sbjct: 681 TPLHLAAGYNNLEVAEYLLQHGADVNAQD-KGGLIPLHNAASYGHVDVAALLIKYNACVN 739
Query: 120 KPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADI 164
D TP+H+AA+ G + + L+A+GA L+N G T D+
Sbjct: 740 ATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDL 784
Score = 55.5 bits (132), Expect = 9e-08
Identities = 35/113 (30%), Positives = 58/113 (51%), Gaps = 1/113 (0%)
Query: 60 TPVHWAAHFGKLECLVQLVRAGATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANIN 119
TP+H AA + +++ + L++ GA ++ + P H A GH + L++ GA +N
Sbjct: 213 TPLHLAAGYNRVKIVQLLLQHGADVHAKD-KGDLVPLHNACSYGHYEVTELLVKHGACVN 271
Query: 120 KPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQE 172
D TP+H+AA +E S L++ GA L N +A D+A T +E
Sbjct: 272 AMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKE 324
Score = 55.1 bits (131), Expect = 1e-07
Identities = 32/107 (29%), Positives = 54/107 (50%), Gaps = 1/107 (0%)
Query: 60 TPVHWAAHFGKLECLVQLVRAGATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANIN 119
TP+H+AA + ++ + L++ GA ++ + P H A GH + L++ GA +N
Sbjct: 528 TPLHFAAGYNRVSVVEYLLQHGADVHAKD-KGGLVPLHNACSYGHYEVAELLVKHGAVVN 586
Query: 120 KPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQ 166
D TP+H+AA G E L+ +GA +N G T D+ +
Sbjct: 587 VADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVK 633
Score = 48.9 bits (115), Expect = 9e-06
Identities = 48/180 (26%), Positives = 72/180 (40%), Gaps = 25/180 (13%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH AC G L++ H + + + +TP+H AA GK E L++ GA
Sbjct: 562 PLHNACSYGHYEVAELLVK---HGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGAD- 617
Query: 85 NVSTTRYAQTPAHIAAFG-----------------GHPQCL--VWLIQAGANINKPDCEG 125
R TP + G CL V + + N+N D +G
Sbjct: 618 PTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQG 677
Query: 126 E--TPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNLQNC 183
TP+H AA +LE L+ +GA V+ ++ GL A + G + A L+ C
Sbjct: 678 RHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNAC 737
Score = 48.1 bits (113), Expect = 1e-05
Identities = 30/106 (28%), Positives = 54/106 (50%), Gaps = 2/106 (1%)
Query: 77 LVRAGATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSG 136
L+R GA +N T + TP H+A+ H + +++ A +N D G+T +H+AA G
Sbjct: 386 LLRKGANINEKTKEFL-TPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCG 444
Query: 137 SLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNLQN 182
L+ L++ G ++ + G TA + + Q+ Q ++L N
Sbjct: 445 HLQTCRLLLSYGCDPNIISLQGFTALQMG-NENVQQLLQEGISLGN 489
Score = 47.0 bits (110), Expect = 3e-05
Identities = 31/105 (29%), Positives = 47/105 (44%)
Query: 65 AAHFGKLECLVQLVRAGATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCE 124
A G +E + +LV + T TP H AA G + +L+Q GAN+ D
Sbjct: 31 ACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDG 90
Query: 125 GETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQG 169
G P+H A G E ++ L+ +GA + R+ T A +G
Sbjct: 91 GLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKG 135
Score = 47.0 bits (110), Expect = 3e-05
Identities = 47/176 (26%), Positives = 75/176 (42%), Gaps = 27/176 (15%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH A ++ + LLQ H + G P+H A +G E LV+ GA +
Sbjct: 529 PLHFAAGYNRVSVVEYLLQHGADVHAKDKG---GLVPLHNACSYGHYEVAELLVKHGAVV 585
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIH-------------- 130
NV+ + TP H AA G + L+Q GA+ K + +G TP+
Sbjct: 586 NVADL-WKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLR 644
Query: 131 ------KAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQ--ECAQFLL 178
AA+ G L + L ++ +V+ R+ G + + G+ E A++LL
Sbjct: 645 GDAALLDAAKKGCLARVKKL-SSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLL 699
Score = 45.1 bits (105), Expect = 1e-04
Identities = 43/179 (24%), Positives = 70/179 (39%), Gaps = 23/179 (12%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
PLH AC G + LL+ H + + +TP+H AA GK++ + L++ GA
Sbjct: 94 PLHNACSFGHAEVVNLLLR---HGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEP 150
Query: 85 NVSTT--RYAQTPAHIAA------------------FGGHPQCLVWLIQAGANINKPDCE 124
+ T R A A +A G + + L N + D
Sbjct: 151 TIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGR 210
Query: 125 GETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNLQNC 183
TP+H AA ++ + L+ +GA V ++ L A + G E + L+ C
Sbjct: 211 KSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGAC 269
Score = 43.9 bits (102), Expect = 3e-04
Identities = 27/85 (31%), Positives = 40/85 (47%)
Query: 94 TPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVDL 153
TP H AA + +L+Q GA+++ D G P+H A G E LV +GA V++
Sbjct: 528 TPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNV 587
Query: 154 RNASGLTAADIAQTQGFQECAQFLL 178
+ T A +G E + LL
Sbjct: 588 ADLWKFTPLHEAAAKGKYEICKLLL 612
Score = 43.9 bits (102), Expect = 3e-04
Identities = 31/112 (27%), Positives = 52/112 (46%), Gaps = 3/112 (2%)
Query: 70 KLECLVQLVRAGATLNVS---TTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGE 126
K CL ++ + + NV+ T TP H+AA + + +L+Q GA++N D G
Sbjct: 654 KKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGL 713
Query: 127 TPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
P+H AA G ++ + L+ A V+ + T A +G + LL
Sbjct: 714 IPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLL 765
Score = 40.8 bits (94), Expect = 0.002
Identities = 29/97 (29%), Positives = 43/97 (44%), Gaps = 6/97 (6%)
Query: 94 TPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVDL 153
TP H+AA + + L+Q GA+++ D P+H A G E LV +GA V+
Sbjct: 213 TPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNA 272
Query: 154 RNASGLTAADIAQTQGFQECAQFLLN------LQNCH 184
+ T A ++ E LL+ L NCH
Sbjct: 273 MDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCH 309
Score = 34.7 bits (78), Expect = 0.17
Identities = 22/63 (34%), Positives = 30/63 (47%), Gaps = 2/63 (3%)
Query: 118 INKPDCEGE--TPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQ 175
+N D G TP+H AA G + + L+ NGA+V R+ GL A + G E
Sbjct: 49 VNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVN 108
Query: 176 FLL 178
LL
Sbjct: 109 LLL 111
>gi|72534772 ankyrin repeat and SOCS box-containing 9 isoform 1
[Homo sapiens]
Length = 294
Score = 72.0 bits (175), Expect = 9e-13
Identities = 62/233 (26%), Positives = 109/233 (46%), Gaps = 18/233 (7%)
Query: 25 PLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATL 84
P+H A G +L +L+ Q ++ + D +P+H A G L C+ L++ GA +
Sbjct: 39 PMHEAAIHGHQLSLRNLISQGWAVNIITADHV---SPLHEACLGGHLSCVKILLKHGAQV 95
Query: 85 NVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISAL 144
N T + TP A G C+ L+Q GA++ +P+ + +PIH+AAR G +EC+++L
Sbjct: 96 NGVTADW-HTPLFNACVSGSWDCVNLLLQHGASV-QPESDLASPIHEAARRGHVECVNSL 153
Query: 145 VANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNLQNCHLNHFYNNGILNGGHQNVFPN 204
+A G ++D + + T +A + C + LL + +N G P
Sbjct: 154 IAYGGNIDHKISHLGTPLYLACENQQRACVKKLLE----------SGADVNQGKGQDSPL 203
Query: 205 HISVGTNRKRCLEDSEDFGVKKARTEAQSLDSAVPLTNGDTEDDADKMHVDRE 257
H T + DFG A T+A++ + P+ E ++ ++RE
Sbjct: 204 HAVARTASEELACLLMDFG---ADTQAKNAEGKRPVELVPPESPLAQLFLERE 253
Score = 66.2 bits (160), Expect = 5e-11
Identities = 39/125 (31%), Positives = 63/125 (50%), Gaps = 2/125 (1%)
Query: 54 DSFYGWTPVHWAAHFGKLECLVQLVRAGATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQ 113
D+ W+P+H AA G L L+ G +N+ T + +P H A GGH C+ L++
Sbjct: 32 DAVSDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHV-SPLHEACLGGHLSCVKILLK 90
Query: 114 AGANINKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQEC 173
GA +N + TP+ A SGS +C++ L+ +GA V + + A+ +G EC
Sbjct: 91 HGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDLASPIHEAAR-RGHVEC 149
Query: 174 AQFLL 178
L+
Sbjct: 150 VNSLI 154
>gi|55742857 ankyrin repeat domain 6 [Homo sapiens]
Length = 722
Score = 71.2 bits (173), Expect = 2e-12
Identities = 40/114 (35%), Positives = 67/114 (58%), Gaps = 2/114 (1%)
Query: 65 AAHFGKLECLVQLVRAGATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCE 124
AA+ G+ E +VQL+ GA V+ T++ +TP H+AA GH + L++AG +++ D
Sbjct: 17 AAYKGQTENVVQLINKGA--RVAVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQDDG 74
Query: 125 GETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
+T +H+A G+ E I+AL+ G +D ++ G TA A GF + A+ L+
Sbjct: 75 DQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLV 128
Score = 60.5 bits (145), Expect = 3e-09
Identities = 39/122 (31%), Positives = 63/122 (51%), Gaps = 1/122 (0%)
Query: 57 YGWTPVHWAAHFGKLECLVQLVRAGATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGA 116
+G TP+H AA+ G L + L++AG L+V QT H A G+ + + LI G
Sbjct: 41 HGRTPLHLAANKGHLPVVQILLKAGCDLDVQDDG-DQTALHRATVVGNTEIIAALIHEGC 99
Query: 117 NINKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQF 176
+++ D +G T +H+A+ G + LV GA+V +N +G TA +A + +
Sbjct: 100 ALDRQDKDGNTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRV 159
Query: 177 LL 178
LL
Sbjct: 160 LL 161
Score = 54.7 bits (130), Expect = 2e-07
Identities = 41/156 (26%), Positives = 66/156 (42%), Gaps = 4/156 (2%)
Query: 23 RFPLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGA 82
R PLH A G L + LL+ + + T +H A G E + L+ G
Sbjct: 43 RTPLHLAANKGHLPVVQILLKAGCDLDVQDDGD---QTALHRATVVGNTEIIAALIHEGC 99
Query: 83 TLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECIS 142
L+ + T H A++ G Q L++AGAN+ + G T +H A ++ +
Sbjct: 100 ALD-RQDKDGNTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTR 158
Query: 143 ALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
L+ G+ DL+N +G T +A + LL
Sbjct: 159 VLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLL 194
Score = 53.9 bits (128), Expect = 3e-07
Identities = 43/153 (28%), Positives = 71/153 (46%), Gaps = 4/153 (2%)
Query: 26 LHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWTPVHWAAHFGKLECLVQLVRAGATLN 85
LHRA G+ + +L+ + +D G T +H A+ G + LV+AGA +
Sbjct: 79 LHRATVVGNTEIIAALIHEGCALDRQDKD---GNTALHEASWHGFSQSAKLLVKAGANV- 134
Query: 86 VSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALV 145
++ + T H+A H Q L+ AG+ + + G+T +H AAR L I L+
Sbjct: 135 LAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLL 194
Query: 146 ANGAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
V +N +G TA +A ++ A+ LL
Sbjct: 195 TAFCSVHEKNQAGDTALHVAAALNHKKVAKILL 227
Score = 40.4 bits (93), Expect = 0.003
Identities = 28/95 (29%), Positives = 45/95 (47%), Gaps = 2/95 (2%)
Query: 98 IAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNAS 157
+AA+ G + +V LI GA + G TP+H AA G L + L+ G +D+++
Sbjct: 16 VAAYKGQTENVVQLINKGARVAVTK-HGRTPLHLAANKGHLPVVQILLKAGCDLDVQDDG 74
Query: 158 GLTAADIAQTQGFQECAQFLLNLQNCHLNHFYNNG 192
TA A G E L++ + C L+ +G
Sbjct: 75 DQTALHRATVVGNTEIIAALIH-EGCALDRQDKDG 108
Score = 35.8 bits (81), Expect = 0.075
Identities = 29/120 (24%), Positives = 51/120 (42%), Gaps = 1/120 (0%)
Query: 58 GWTPVHWAAHFGKLECLVQLVRAGATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGAN 117
G T +H A + L+ AG+ ++ T H+AA H + L+ A +
Sbjct: 141 GNTALHLACQNSHSQSTRVLLLAGSRADLKNNA-GDTCLHVAARYNHLSIIRLLLTAFCS 199
Query: 118 INKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFL 177
+++ + G+T +H AA + L+ GA + N +G T + A+ E A L
Sbjct: 200 VHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALLL 259
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.131 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,648,537
Number of Sequences: 37866
Number of extensions: 845983
Number of successful extensions: 4490
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 318
Number of HSP's successfully gapped in prelim test: 66
Number of HSP's that attempted gapping in prelim test: 2111
Number of HSP's gapped (non-prelim): 1414
length of query: 420
length of database: 18,247,518
effective HSP length: 105
effective length of query: 315
effective length of database: 14,271,588
effective search space: 4495550220
effective search space used: 4495550220
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.