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Search of human proteins with 7019483
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7019483 procollagen C-endopeptidase enhancer 2 [Homo
sapiens]
(415 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7019483 procollagen C-endopeptidase enhancer 2 [Homo sapiens] 859 0.0
gi|157653329 procollagen C-endopeptidase enhancer [Homo sapiens] 384 e-106
gi|6912724 tolloid-like 2 [Homo sapiens] 160 2e-39
gi|72384339 CUB domain containing protein 2 [Homo sapiens] 160 3e-39
gi|22547221 tolloid-like 1 [Homo sapiens] 158 1e-38
gi|4502421 bone morphogenetic protein 1 isoform 1 precursor [Hom... 152 4e-37
gi|5902808 bone morphogenetic protein 1 isoform 2 precursor [Hom... 152 4e-37
gi|5453579 bone morphogenetic protein 1 isoform 3 precursor [Hom... 152 4e-37
gi|126091152 cubilin [Homo sapiens] 149 3e-36
gi|13899255 membrane frizzled-related protein [Homo sapiens] 143 3e-34
gi|66864913 neuropilin 1 isoform c [Homo sapiens] 141 1e-33
gi|66912178 neuropilin 1 isoform b [Homo sapiens] 141 1e-33
gi|182508169 neuropilin 1 isoform a [Homo sapiens] 141 1e-33
gi|41872572 neuropilin 2 isoform 3 precursor [Homo sapiens] 131 1e-30
gi|41872567 neuropilin 2 isoform 5 precursor [Homo sapiens] 131 1e-30
gi|41872562 neuropilin 2 isoform 1 precursor [Homo sapiens] 131 1e-30
gi|41872557 neuropilin 2 isoform 6 precursor [Homo sapiens] 131 1e-30
gi|41872544 neuropilin 2 isoform 4 precursor [Homo sapiens] 131 1e-30
gi|41872533 neuropilin 2 isoform 2 precursor [Homo sapiens] 131 1e-30
gi|148231605 ovochymase 2 [Homo sapiens] 116 4e-26
gi|30520377 CUB and zona pellucida-like domains 1 [Homo sapiens] 108 7e-24
gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens] 101 1e-21
gi|11415040 matriptase [Homo sapiens] 100 2e-21
gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sap... 95 1e-19
gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo sa... 95 1e-19
gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sap... 95 1e-19
gi|73623026 mannan-binding lectin serine protease 1 isoform 3 [H... 92 7e-19
gi|21264359 mannan-binding lectin serine protease 1 isoform 2 pr... 92 7e-19
gi|21264357 mannan-binding lectin serine protease 1 isoform 1 pr... 92 7e-19
gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens] 91 2e-18
>gi|7019483 procollagen C-endopeptidase enhancer 2 [Homo sapiens]
Length = 415
Score = 859 bits (2219), Expect = 0.0
Identities = 415/415 (100%), Positives = 415/415 (100%)
Query: 1 MRGANAWAPLCLLLAAATQLSRQQSPERPVFTCGGILTGESGFIGSEGFPGVYPPNSKCT 60
MRGANAWAPLCLLLAAATQLSRQQSPERPVFTCGGILTGESGFIGSEGFPGVYPPNSKCT
Sbjct: 1 MRGANAWAPLCLLLAAATQLSRQQSPERPVFTCGGILTGESGFIGSEGFPGVYPPNSKCT 60
Query: 61 WKITVPEGKVVVLNFRFIDLESDNLCRYDFVDVYNGHANGQRIGRFCGTFRPGALVSSGN 120
WKITVPEGKVVVLNFRFIDLESDNLCRYDFVDVYNGHANGQRIGRFCGTFRPGALVSSGN
Sbjct: 61 WKITVPEGKVVVLNFRFIDLESDNLCRYDFVDVYNGHANGQRIGRFCGTFRPGALVSSGN 120
Query: 121 KMMVQMISDANTAGNGFMAMFSAAEPNERGDQYCGGLLDRPSGSFKTPNWPDRDYPAGVT 180
KMMVQMISDANTAGNGFMAMFSAAEPNERGDQYCGGLLDRPSGSFKTPNWPDRDYPAGVT
Sbjct: 121 KMMVQMISDANTAGNGFMAMFSAAEPNERGDQYCGGLLDRPSGSFKTPNWPDRDYPAGVT 180
Query: 181 CVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVAVFNGGEVNDARRIGKYCGDSPPAPIV 240
CVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVAVFNGGEVNDARRIGKYCGDSPPAPIV
Sbjct: 181 CVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVAVFNGGEVNDARRIGKYCGDSPPAPIV 240
Query: 241 SERNELLIQFLSDLSLTADGFIGHYIFRPKKLPTTTEQPVTTTFPVTTGLKPTVALCQQK 300
SERNELLIQFLSDLSLTADGFIGHYIFRPKKLPTTTEQPVTTTFPVTTGLKPTVALCQQK
Sbjct: 241 SERNELLIQFLSDLSLTADGFIGHYIFRPKKLPTTTEQPVTTTFPVTTGLKPTVALCQQK 300
Query: 301 CRRTGTLEGNYCSSDFVLAGTVITTITRDGSLHATVSIINIYKEGNLAIQQAGKNMSARL 360
CRRTGTLEGNYCSSDFVLAGTVITTITRDGSLHATVSIINIYKEGNLAIQQAGKNMSARL
Sbjct: 301 CRRTGTLEGNYCSSDFVLAGTVITTITRDGSLHATVSIINIYKEGNLAIQQAGKNMSARL 360
Query: 361 TVVCKQCPLLRRGLNYIIMGQVGEDGRGKIMPNSFIMMFKTKNQKLLDALKNKQC 415
TVVCKQCPLLRRGLNYIIMGQVGEDGRGKIMPNSFIMMFKTKNQKLLDALKNKQC
Sbjct: 361 TVVCKQCPLLRRGLNYIIMGQVGEDGRGKIMPNSFIMMFKTKNQKLLDALKNKQC 415
>gi|157653329 procollagen C-endopeptidase enhancer [Homo sapiens]
Length = 449
Score = 384 bits (985), Expect = e-106
Identities = 194/436 (44%), Positives = 272/436 (62%), Gaps = 29/436 (6%)
Query: 4 ANAWAPLCLLLAAATQLSRQQSPE--RPVFTCGGILTGESGFIGSEGFPGVYPPNSKCTW 61
A+ PL L A ++ Q+P RPVF CGG + GESG++ SEGFP +YPPN +C W
Sbjct: 7 ASLLGPL-LTACALLPFAQGQTPNYTRPVFLCGGDVKGESGYVASEGFPNLYPPNKECIW 65
Query: 62 KITVPEGKVVVLNFRFIDLESDNLCRYDFVDVYNGHA-NGQRIGRFCGTFRPGALVSSGN 120
ITVPEG+ V L+FR DLE CRYD ++V+ G +GQR+GRFCGTFRP LV+ GN
Sbjct: 66 TITVPEGQTVSLSFRVFDLELHPACRYDALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGN 125
Query: 121 KMMVQMISDANTAGNGFMAMFSAAEPNERGDQYCGGLLDRPSGSFKTPNWPDRDYPAGVT 180
++ ++M +D T G GF+ +S + Q+CGG L++ G+ TPNWP+ DYP G++
Sbjct: 126 QVTLRMTTDEGTGGRGFLLWYSGRATSGTEHQFCGGRLEKAQGTLTTPNWPESDYPPGIS 185
Query: 181 CVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVAVFNGGEVNDARRIGKYCGDSPPAPIV 240
C WHI+AP +Q+I L FEKFD+E D YCRYD V+VFNG +D+RR+GK+CGD+ P I
Sbjct: 186 CSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCGDAVPGSIS 245
Query: 241 SERNELLIQFLSDLSLTADGFIGHYIFRPK-------------------KLPTTTEQPVT 281
SE NELL+QF+SDLS+TADGF Y P+ KLP ++ P
Sbjct: 246 SEGNELLVQFVSDLSVTADGFSASYKTLPRGTAKEGQGPGPKRGTEPKVKLPPKSQPPEK 305
Query: 282 TTFPVTTGLKPTVALCQQKCRRTGTLEGNYCSSDFVLAGTVITTITRDG-SLHATVSIIN 340
T + PT C ++CRRTGTL+ N+C+S V+ TV + + G L TVS+I
Sbjct: 306 TEESPSAPDAPT---CPKQCRRTGTLQSNFCASSLVVTATVKSMVREPGEGLAVTVSLIG 362
Query: 341 IYKEGNLAIQQAGKNMSARLTVVCKQCPLLRRGLNYIIMGQVGEDGRGKIM-PNSFIMMF 399
YK G L + S + V CKQCP +++G++Y++MGQV E+ RG ++ P SF+++
Sbjct: 363 AYKTGGLDLPSPPTGASLKFYVPCKQCPPMKKGVSYLLMGQV-EENRGPVLPPESFVVLH 421
Query: 400 KTKNQKLLDALKNKQC 415
+ ++L L ++C
Sbjct: 422 RPNQDQILTNLSKRKC 437
>gi|6912724 tolloid-like 2 [Homo sapiens]
Length = 1015
Score = 160 bits (405), Expect = 2e-39
Identities = 84/234 (35%), Positives = 127/234 (54%), Gaps = 12/234 (5%)
Query: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVD 92
CG L +G + GFP YP S C W+I+V G+ +VLNF +DL LC YD+V+
Sbjct: 351 CGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLCWYDYVE 410
Query: 93 VYNGH-ANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNERGD 151
V +G+ +GRFCG P LVS+ +++ V+ S +N G GF A + A
Sbjct: 411 VRDGYWRKAPLLGRFCGDKIPEPLVSTDSRLWVEFRSSSNILGKGFFAAYEAT------- 463
Query: 152 QYCGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYD 211
CGG +++ +G ++PN+PD DY CVW I + + L F+ F++ER + C YD
Sbjct: 464 --CGGDMNKDAGQIQSPNYPD-DYRPSKECVWRITVSEGFHVGLTFQAFEIERHDSCAYD 520
Query: 212 YVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIGHY 265
Y+ V G ++ IG +CG P + S N L ++F+SD S+ GF ++
Sbjct: 521 YLEV-RDGPTEESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANF 573
Score = 155 bits (393), Expect = 5e-38
Identities = 85/269 (31%), Positives = 138/269 (51%), Gaps = 37/269 (13%)
Query: 32 TCGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFV 91
TCGG + ++G I S +P Y P+ +C W+ITV EG V L F+ ++E + C YD++
Sbjct: 463 TCGGDMNKDAGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQAFEIERHDSCAYDYL 522
Query: 92 DVYNGHANGQR-IGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMF-----SAAE 145
+V +G IG FCG +P + SS N++ ++ +SD + GF A F +
Sbjct: 523 EVRDGPTEESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANFFKEVDECSW 582
Query: 146 PNERGDQY-----------------------------CGGLLDRPSGSFKTPNWPDRDYP 176
P+ G ++ CGG + + +G+ +P WP ++YP
Sbjct: 583 PDHGGCEHRCVNTLGSYKCACDPGYELAADKKMCEVACGGFITKLNGTITSPGWP-KEYP 641
Query: 177 AGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVAVFNGGEVNDARRIGKYCGDSPP 236
CVW +VAP I L+FE F++E ++ C+YD+V V G DA+ G++CG P
Sbjct: 642 TNKNCVWQVVAPAQYRISLQFEVFELEGNDVCKYDFVEV-RSGLSPDAKLHGRFCGSETP 700
Query: 237 APIVSERNELLIQFLSDLSLTADGFIGHY 265
I S+ N + ++F SD +++ GF H+
Sbjct: 701 EVITSQSNNMRVEFKSDNTVSKRGFRAHF 729
Score = 134 bits (337), Expect = 2e-31
Identities = 75/237 (31%), Positives = 119/237 (50%), Gaps = 14/237 (5%)
Query: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVD 92
C ++ G + S +P YP +CTW I+ G V L F ++E C YD ++
Sbjct: 776 CAHKISSVEGTLASPNWPDKYPSRRECTWNISSTAGHRVKLTFNEFEIEQHQECAYDHLE 835
Query: 93 VYNG-HANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNERGD 151
+Y+G + +GRFCG+ +P V+SG+ M ++ SDA+ GF A+ S
Sbjct: 836 MYDGPDSLAPILGRFCGSKKPDPTVASGSSMFLRFYSDASVQRKGFQAVHSTE------- 888
Query: 152 QYCGGLLD---RPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYC 208
CGG L + + + D +YP+ C W IVA +EL F F+VE + C
Sbjct: 889 --CGGRLKAEVQTKELYSHAQFGDNNYPSEARCDWVIVAEDGYGVELTFRTFEVEEEADC 946
Query: 209 RYDYVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIGHY 265
YDY+ ++G + + A R+G++CG P I S + L+I+F +D ++ GF Y
Sbjct: 947 GYDYMEAYDGYD-SSAPRLGRFCGSGPLEEIYSAGDSLMIRFRTDDTINKKGFHARY 1002
Score = 65.5 bits (158), Expect = 9e-11
Identities = 29/94 (30%), Positives = 55/94 (58%), Gaps = 1/94 (1%)
Query: 53 YPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVDVYNGH-ANGQRIGRFCGTFR 111
YP ++C W I +G V L FR ++E + C YD+++ Y+G+ ++ R+GRFCG+
Sbjct: 913 YPSEARCDWVIVAEDGYGVELTFRTFEVEEEADCGYDYMEAYDGYDSSAPRLGRFCGSGP 972
Query: 112 PGALVSSGNKMMVQMISDANTAGNGFMAMFSAAE 145
+ S+G+ +M++ +D GF A +++ +
Sbjct: 973 LEEIYSAGDSLMIRFRTDDTINKKGFHARYTSTK 1006
>gi|72384339 CUB domain containing protein 2 [Homo sapiens]
Length = 449
Score = 160 bits (404), Expect = 3e-39
Identities = 96/257 (37%), Positives = 131/257 (50%), Gaps = 14/257 (5%)
Query: 11 CLLLAAATQLSRQQSPERPVFTCGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKV 70
CLLLA A Q+ CGG+L+ SG S FP +YP N++C+W I V EG
Sbjct: 8 CLLLAVALLGPGLQAQAMEGVKCGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSS 67
Query: 71 VVLNFRFIDLESDNLCRYDFVDVYNGHA--NGQRIGRFCGTFRPGALVSSGNKMMVQMIS 128
V+L F DLE + C +DF+++YNG + G +GRFCG P SS + M V S
Sbjct: 68 VLLTFHAFDLEYHDTCSFDFLEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHS 127
Query: 129 DANTAGNGFMAMFSAAEPNERGDQYCGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAP 188
D + A +GF A + CGG+L SG +P +P+ +YP + C W I A
Sbjct: 128 DKHVASHGFSAGYQ--------KDVCGGVLTGLSGVLTSPEYPN-NYPNSMECHWVIRAA 178
Query: 189 KNQLIELKFEKFDVERDNYCRYDYVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLI 248
++L F F VE + C YDYVAV G R YCG + P +VS +EL +
Sbjct: 179 GPAHVKLVFVDFQVEGNEECTYDYVAVLGG---PGPTRGHHYCGSTRPPTLVSLGHELQV 235
Query: 249 QFLSDLSLTADGFIGHY 265
F SD ++ GF +Y
Sbjct: 236 VFKSDFNIGGRGFKAYY 252
Score = 130 bits (326), Expect = 3e-30
Identities = 92/313 (29%), Positives = 135/313 (43%), Gaps = 40/313 (12%)
Query: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVD 92
CGG+LTG SG + S +P YP + +C W I V L F +E + C YD+V
Sbjct: 145 CGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVA 204
Query: 93 VYNGHANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNERGDQ 152
V G R +CG+ RP LVS G+++ V SD N G GF A + + E
Sbjct: 205 VLGG-PGPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFSGE------- 256
Query: 153 YCGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDN----YC 208
C + G+F +P +P YP + C W I P +++ F D+E N C
Sbjct: 257 -CQEVYMAMRGNFSSPQYPS-SYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTC 314
Query: 209 RYDYVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIGHYI-- 266
+D++A F+G +A +G +CG P P+ S N+LL+ +D S T GF YI
Sbjct: 315 DFDHLAAFDGAS-EEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAYIGG 373
Query: 267 ---------------FRPKKLPTTTEQPVTTTFPVTTGLKPTVALCQQKCRRTGTLE--- 308
+P+ L + + P P GL + C +G L
Sbjct: 374 QLGCGSGSTEGEGEALQPQSLQSPSSIPPVCPAPPMNGLLQLLLHWLHPCPLSGPLRLDG 433
Query: 309 -----GNYCSSDF 316
+YC + F
Sbjct: 434 TAPACFHYCRASF 446
>gi|22547221 tolloid-like 1 [Homo sapiens]
Length = 1013
Score = 158 bits (399), Expect = 1e-38
Identities = 89/268 (33%), Positives = 137/268 (51%), Gaps = 37/268 (13%)
Query: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVD 92
CGG + G I S +P Y P +C WKITV E V L F+ ++E + C YD+++
Sbjct: 462 CGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDYLE 521
Query: 93 VYNGHA-NGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMF-----SAAEP 146
V +G + N IGRFCG +P + S+ N + ++ +SD GF A F A+P
Sbjct: 522 VRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDECAKP 581
Query: 147 NERG-----------------------------DQYCGGLLDRPSGSFKTPNWPDRDYPA 177
+ G + CGGLL + +G+ TP WP ++YP
Sbjct: 582 DRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPGWP-KEYPP 640
Query: 178 GVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVAVFNGGEVNDARRIGKYCGDSPPA 237
CVW +VAP I +KFE F++E + C+YDYV +++G ++++ GK+CG P
Sbjct: 641 NKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSGLS-SESKLHGKFCGAEVPE 699
Query: 238 PIVSERNELLIQFLSDLSLTADGFIGHY 265
I S+ N + I+F SD +++ GF H+
Sbjct: 700 VITSQFNNMRIEFKSDNTVSKKGFKAHF 727
Score = 157 bits (398), Expect = 1e-38
Identities = 82/234 (35%), Positives = 130/234 (55%), Gaps = 12/234 (5%)
Query: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVD 92
CG L +G + S GFP YP + C W+++V G+ +VLNF +DL +LC YD+++
Sbjct: 349 CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIE 408
Query: 93 VYNGH-ANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNERGD 151
V +G+ +GRFCG P L S+ ++M ++ S +N G GF A++ A
Sbjct: 409 VRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEA-------- 460
Query: 152 QYCGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYD 211
CGG + + G ++PN+PD DY CVW I ++ + L F+ F++ER + C YD
Sbjct: 461 -ICGGEIRKNEGQIQSPNYPD-DYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYD 518
Query: 212 YVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIGHY 265
Y+ V +G N + IG++CG P I S N L ++F+SD ++ GF ++
Sbjct: 519 YLEVRDGTSEN-SPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANF 571
Score = 147 bits (372), Expect = 1e-35
Identities = 84/248 (33%), Positives = 127/248 (51%), Gaps = 16/248 (6%)
Query: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVD 92
C + SG I S +P YP +CTW+I+ G + L F ++E C YD ++
Sbjct: 774 CEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLE 833
Query: 93 VYNGHANGQRI-GRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNERGD 151
V++G I GR CG P LV++GNKM V+ +SDA+ GF A S
Sbjct: 834 VFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATHSTE------- 886
Query: 152 QYCGGLL---DRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYC 208
CGG L +P + + D +YP V C W +V+ + +EL F+ F+VE + C
Sbjct: 887 --CGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQTFEVEEEADC 944
Query: 209 RYDYVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIGHYIFR 268
YDYV +F+G + + A +G++CG PP I S + +LI F +D ++ GF H ++
Sbjct: 945 GYDYVELFDGLD-STAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGF--HIRYK 1001
Query: 269 PKKLPTTT 276
+ P TT
Sbjct: 1002 SIRYPDTT 1009
>gi|4502421 bone morphogenetic protein 1 isoform 1 precursor [Homo
sapiens]
Length = 730
Score = 152 bits (385), Expect = 4e-37
Identities = 82/268 (30%), Positives = 134/268 (50%), Gaps = 37/268 (13%)
Query: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVD 92
CGG + + G I S +P Y P+ C W+I V EG V L F+ ++E + C YD+++
Sbjct: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
Query: 93 VYNGHANGQR-IGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMF-----SAAEP 146
V +GH+ IGR+CG +P + S+ +++ ++ +SD + GF F + P
Sbjct: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRP 554
Query: 147 NERG-----------------------------DQYCGGLLDRPSGSFKTPNWPDRDYPA 177
N G + CGG L + +GS +P WP ++YP
Sbjct: 555 NRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWP-KEYPP 613
Query: 178 GVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVAVFNGGEVNDARRIGKYCGDSPPA 237
C+W +VAP I L+F+ F+ E ++ C+YD+V V G D++ GK+CG P
Sbjct: 614 NKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEV-RSGLTADSKLHGKFCGSEKPE 672
Query: 238 PIVSERNELLIQFLSDLSLTADGFIGHY 265
I S+ N + ++F SD +++ GF H+
Sbjct: 673 VITSQYNNMRVEFKSDNTVSKKGFKAHF 700
Score = 148 bits (373), Expect = 1e-35
Identities = 89/284 (31%), Positives = 137/284 (48%), Gaps = 31/284 (10%)
Query: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVD 92
CG L +G S +P Y + C W+I+V G+ ++LNF +DL LC YD+V+
Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
Query: 93 VYNGHANGQRI-GRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNERGD 151
V +G + GRFCG+ P +VS+ +++ V+ S +N G GF A++ A
Sbjct: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEA-------- 433
Query: 152 QYCGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYD 211
CGG + + G ++PN+PD DY C+W I + + L F+ F++ER + C YD
Sbjct: 434 -ICGGDVKKDYGHIQSPNYPD-DYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491
Query: 212 YVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIGHYIFRPKK 271
Y+ V G + IG+YCG P I S + L ++F+SD S+ GF ++
Sbjct: 492 YLEV-RDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKE--- 547
Query: 272 LPTTTEQPVTTTFPVTTGLKPTVALCQQKCRRTGTLEGNYCSSD 315
V +P C+Q+C TL CS D
Sbjct: 548 --------------VDECSRPNRGGCEQRC--LNTLGSYKCSCD 575
>gi|5902808 bone morphogenetic protein 1 isoform 2 precursor [Homo
sapiens]
Length = 823
Score = 152 bits (385), Expect = 4e-37
Identities = 82/268 (30%), Positives = 134/268 (50%), Gaps = 37/268 (13%)
Query: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVD 92
CGG + + G I S +P Y P+ C W+I V EG V L F+ ++E + C YD+++
Sbjct: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
Query: 93 VYNGHANGQR-IGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMF-----SAAEP 146
V +GH+ IGR+CG +P + S+ +++ ++ +SD + GF F + P
Sbjct: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRP 554
Query: 147 NERG-----------------------------DQYCGGLLDRPSGSFKTPNWPDRDYPA 177
N G + CGG L + +GS +P WP ++YP
Sbjct: 555 NRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWP-KEYPP 613
Query: 178 GVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVAVFNGGEVNDARRIGKYCGDSPPA 237
C+W +VAP I L+F+ F+ E ++ C+YD+V V G D++ GK+CG P
Sbjct: 614 NKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEV-RSGLTADSKLHGKFCGSEKPE 672
Query: 238 PIVSERNELLIQFLSDLSLTADGFIGHY 265
I S+ N + ++F SD +++ GF H+
Sbjct: 673 VITSQYNNMRVEFKSDNTVSKKGFKAHF 700
Score = 148 bits (373), Expect = 1e-35
Identities = 89/284 (31%), Positives = 137/284 (48%), Gaps = 31/284 (10%)
Query: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVD 92
CG L +G S +P Y + C W+I+V G+ ++LNF +DL LC YD+V+
Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
Query: 93 VYNGHANGQRI-GRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNERGD 151
V +G + GRFCG+ P +VS+ +++ V+ S +N G GF A++ A
Sbjct: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEA-------- 433
Query: 152 QYCGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYD 211
CGG + + G ++PN+PD DY C+W I + + L F+ F++ER + C YD
Sbjct: 434 -ICGGDVKKDYGHIQSPNYPD-DYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491
Query: 212 YVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIGHYIFRPKK 271
Y+ V G + IG+YCG P I S + L ++F+SD S+ GF ++
Sbjct: 492 YLEV-RDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKE--- 547
Query: 272 LPTTTEQPVTTTFPVTTGLKPTVALCQQKCRRTGTLEGNYCSSD 315
V +P C+Q+C TL CS D
Sbjct: 548 --------------VDECSRPNRGGCEQRC--LNTLGSYKCSCD 575
>gi|5453579 bone morphogenetic protein 1 isoform 3 precursor [Homo
sapiens]
Length = 986
Score = 152 bits (385), Expect = 4e-37
Identities = 82/268 (30%), Positives = 134/268 (50%), Gaps = 37/268 (13%)
Query: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVD 92
CGG + + G I S +P Y P+ C W+I V EG V L F+ ++E + C YD+++
Sbjct: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLE 494
Query: 93 VYNGHANGQR-IGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMF-----SAAEP 146
V +GH+ IGR+CG +P + S+ +++ ++ +SD + GF F + P
Sbjct: 495 VRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRP 554
Query: 147 NERG-----------------------------DQYCGGLLDRPSGSFKTPNWPDRDYPA 177
N G + CGG L + +GS +P WP ++YP
Sbjct: 555 NRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWP-KEYPP 613
Query: 178 GVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVAVFNGGEVNDARRIGKYCGDSPPA 237
C+W +VAP I L+F+ F+ E ++ C+YD+V V G D++ GK+CG P
Sbjct: 614 NKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEV-RSGLTADSKLHGKFCGSEKPE 672
Query: 238 PIVSERNELLIQFLSDLSLTADGFIGHY 265
I S+ N + ++F SD +++ GF H+
Sbjct: 673 VITSQYNNMRVEFKSDNTVSKKGFKAHF 700
Score = 149 bits (375), Expect = 6e-36
Identities = 80/233 (34%), Positives = 127/233 (54%), Gaps = 14/233 (6%)
Query: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVD 92
C +T SG I S +P YP +CTW I+ G V L F +D+ES C YD ++
Sbjct: 747 CDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHLE 806
Query: 93 VYNGH-ANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNERGD 151
V++G A +GRFCG+ +P ++++G++M ++ SD + GF A +
Sbjct: 807 VFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLRFYSDNSVQRKGFQASHATE------- 859
Query: 152 QYCGGLLD---RPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYC 208
CGG + + + + D +YP GV C W IVA + +EL F+ F+VE + C
Sbjct: 860 --CGGQVRADVKTKDLYSHAQFGDNNYPGGVDCEWVIVAEEGYGVELVFQTFEVEEETDC 917
Query: 209 RYDYVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGF 261
YDY+ +F+G + + A R+G+YCG PP + S + +L++F SD ++T GF
Sbjct: 918 GYDYMELFDGYD-STAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDTITKKGF 969
Score = 148 bits (373), Expect = 1e-35
Identities = 89/284 (31%), Positives = 137/284 (48%), Gaps = 31/284 (10%)
Query: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVD 92
CG L +G S +P Y + C W+I+V G+ ++LNF +DL LC YD+V+
Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
Query: 93 VYNGHANGQRI-GRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNERGD 151
V +G + GRFCG+ P +VS+ +++ V+ S +N G GF A++ A
Sbjct: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEA-------- 433
Query: 152 QYCGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYD 211
CGG + + G ++PN+PD DY C+W I + + L F+ F++ER + C YD
Sbjct: 434 -ICGGDVKKDYGHIQSPNYPD-DYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYD 491
Query: 212 YVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIGHYIFRPKK 271
Y+ V G + IG+YCG P I S + L ++F+SD S+ GF ++
Sbjct: 492 YLEV-RDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKE--- 547
Query: 272 LPTTTEQPVTTTFPVTTGLKPTVALCQQKCRRTGTLEGNYCSSD 315
V +P C+Q+C TL CS D
Sbjct: 548 --------------VDECSRPNRGGCEQRC--LNTLGSYKCSCD 575
Score = 61.6 bits (148), Expect = 1e-09
Identities = 28/94 (29%), Positives = 53/94 (56%), Gaps = 1/94 (1%)
Query: 53 YPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVDVYNGH-ANGQRIGRFCGTFR 111
YP C W I EG V L F+ ++E + C YD++++++G+ + R+GR+CG+
Sbjct: 884 YPGGVDCEWVIVAEEGYGVELVFQTFEVEEETDCGYDYMELFDGYDSTAPRLGRYCGSGP 943
Query: 112 PGALVSSGNKMMVQMISDANTAGNGFMAMFSAAE 145
P + S+G+ ++V+ SD GF +++ +
Sbjct: 944 PEEVYSAGDSVLVKFHSDDTITKKGFHLRYTSTK 977
>gi|126091152 cubilin [Homo sapiens]
Length = 3623
Score = 149 bits (377), Expect = 3e-36
Identities = 83/234 (35%), Positives = 124/234 (52%), Gaps = 12/234 (5%)
Query: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVD 92
CG LTGE G I S FP VYP C W I P+ +V++LNF ++ S C D+V+
Sbjct: 817 CGDELTGE-GVIRSPFFPNVYPGERTCRWTIHQPQSQVILLNFTVFEIGSSAHCETDYVE 875
Query: 93 VYNGHANGQ-RIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNERGD 151
+ + G ++CGT P + S N + V + ++T +GFMA FSA D
Sbjct: 876 IGSSSILGSPENKKYCGTDIPSFITSVYNFLYVTFVKSSSTENHGFMAKFSAE------D 929
Query: 152 QYCGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYD 211
CG +L +G+ ++P P+ YP G+ C WHI+ N LI L FE F +E C D
Sbjct: 930 LACGEILTESTGTIQSPGHPN-VYPHGINCTWHILVQPNHLIHLMFETFHLEFHYNCTND 988
Query: 212 YVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIGHY 265
Y+ V+ + + +G+YCG S P + S N L++ F++D L +GF+ +Y
Sbjct: 989 YLEVY---DTDSETSLGRYCGKSIPPSLTSSGNSLMLVFVTDSDLAYEGFLINY 1039
Score = 142 bits (359), Expect = 4e-34
Identities = 81/242 (33%), Positives = 128/242 (52%), Gaps = 10/242 (4%)
Query: 30 VFTCGGILTGESGFIGSEGFPGV-YPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRY 88
+ +CGG+ SG I S + YP + C + ITV + KV+ L F D+ C +
Sbjct: 3034 IISCGGVFNFSSGIITSPAYSYADYPNDMHCLYTITVSDDKVIELKFSDFDVVPSTSCSH 3093
Query: 89 DFVDVYNG-HANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPN 147
D++ +Y+G + + +G+FCG+ RP + SS N M++ +D+ G+ F
Sbjct: 3094 DYLAIYDGANTSDPLLGKFCGSKRPPNVKSSNNSMLLVFKTDSFQTAKGWKMSFRQTLGP 3153
Query: 148 ERGDQYCGGLLDRPSGSFKTPNWPDRD-YPAGVTCVWHIVAPKNQLIELKFEKFDVERDN 206
++G CGG L + +F +P+ Y + CVW I+AP N++I L F F +E +
Sbjct: 3154 QQG---CGGYLTGSNNTFASPDSDSNGMYDKNLNCVWIIIAPVNKVIHLTFNTFALEAAS 3210
Query: 207 Y---CRYDYVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIG 263
C YDYV +++G N A G +CG + PAP +S N L +QF+SDL+L +GF
Sbjct: 3211 TRQRCLYDYVKLYDGDSEN-ANLAGTFCGSTVPAPFISSGNFLTVQFISDLTLEREGFNA 3269
Query: 264 HY 265
Y
Sbjct: 3270 TY 3271
Score = 125 bits (313), Expect = 9e-29
Identities = 81/247 (32%), Positives = 119/247 (48%), Gaps = 15/247 (6%)
Query: 21 SRQQSPERPVF--TCGG-ILTGESGFIGSEGFPGVYPPNSKCTWKITV-PEGKVVVLNFR 76
SRQ R F CGG ILT + S FP YP N C+W I P + L+F
Sbjct: 1606 SRQNRGFRAQFRQACGGHILTSSFDTVSSPRFPANYPNNQNCSWIIQAQPPLNHITLSFT 1665
Query: 77 FIDLESDNLCRYDFVDVYNG-HANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGN 135
+LE C DFV++ +G H + GR+CGT P + S + + ++ +SD++ +
Sbjct: 1666 HFELERSTTCARDFVEILDGGHEDAPLRGRYCGTDMPHPITSFSSALTLRFVSDSSISAG 1725
Query: 136 GFMAMFSAAEPNERGDQYCGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIEL 195
GF +A+ CGG G F +P +PD YP V CVW+IV+ ++L
Sbjct: 1726 GFHTTVTASV------SACGGTFYMAEGIFNSPGYPD-IYPPNVECVWNIVSSPGNRLQL 1778
Query: 196 KFEKFDVERDNYCRYDYVAVFNGGEVNDARRIGKYCGDSPPAPIVS-ERNELLIQFLSDL 254
F F +E C D+V + G +G+YCG+S P S + L ++F+SD
Sbjct: 1779 SFISFQLEDSQDCSRDFVEIREGNAT--GHLVGRYCGNSFPLNYSSIVGHTLWVRFISDG 1836
Query: 255 SLTADGF 261
S + GF
Sbjct: 1837 SGSGTGF 1843
Score = 124 bits (312), Expect = 1e-28
Identities = 73/234 (31%), Positives = 110/234 (47%), Gaps = 12/234 (5%)
Query: 30 VFTCGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYD 89
V CGG G S G+P +YPPN +C W I G + L+F LE C D
Sbjct: 1735 VSACGGTFYMAEGIFNSPGYPDIYPPNVECVWNIVSSPGNRLQLSFISFQLEDSQDCSRD 1794
Query: 90 FVDVYNGHANGQRIGRFCGTFRPGALVS-SGNKMMVQMISDANTAGNGFMAMFSAAEPNE 148
FV++ G+A G +GR+CG P S G+ + V+ ISD + +G GF A F N+
Sbjct: 1795 FVEIREGNATGHLVGRYCGNSFPLNYSSIVGHTLWVRFISDGSGSGTGFQATFMKIFGND 1854
Query: 149 RGDQYCGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYC 208
+ G +P WP+ +YP W + + ++ + + D+E C
Sbjct: 1855 N--------IVGTHGKVASPFWPE-NYPHNSNYQWTVNVNASHVVHGRILEMDIEEIQNC 1905
Query: 209 RYDYVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFI 262
YD + +++G ++ AR IG YCG + S N L F SD S++ GF+
Sbjct: 1906 YYDKLRIYDGPSIH-ARLIGAYCGTQTES-FSSTGNSLTFHFYSDSSISGKGFL 1957
Score = 123 bits (309), Expect = 3e-28
Identities = 76/237 (32%), Positives = 111/237 (46%), Gaps = 17/237 (7%)
Query: 30 VFTCGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYD 89
V+ CGG L+G +G S GFP YPPN +C W I G + L D+E + C +D
Sbjct: 1388 VYGCGGELSGATGSFSSPGFPNRYPPNKECIWYIRTDPGSSIQLTIHDFDVEYHSRCNFD 1447
Query: 90 FVDVYNG-HANGQRIGRFC---GTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAE 145
+++Y G + RI + C P + S+GN++ ++ +D + G GF A + A
Sbjct: 1448 VLEIYGGPDFHSPRIAQLCTQRSPENPMQVSSTGNELAIRFKTDLSINGRGFNASWQAVT 1507
Query: 146 PNERGDQYCGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERD 205
CGG+ PSG +PN+P Y + C W I +N + L F FD+E
Sbjct: 1508 GG------CGGIFQAPSGEIHSPNYPS-PYRSNTDCSWVIRVDRNHRVLLNFTDFDLEPQ 1560
Query: 206 NYCRYDYVAVFNGGEVNDARRIGKYCGDSPPA-PIVSERNELLIQFLSDLSLTADGF 261
+ C Y G + R+ + CG A PIVS N L ++F S S GF
Sbjct: 1561 DSCIMAY-----DGLSSTMSRLARTCGREQLANPIVSSGNSLFLRFQSGPSRQNRGF 1612
Score = 122 bits (307), Expect = 5e-28
Identities = 76/245 (31%), Positives = 116/245 (47%), Gaps = 9/245 (3%)
Query: 29 PVFTCGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRY 88
P CG L+G +G Y + C W I GKV+ + F F LES + C +
Sbjct: 470 PQQVCGESLSGINGSFSYRSPDVGYVHDVNCFWVIKTEMGKVLRITFTFFRLESMDNCPH 529
Query: 89 DFVDVYNGHANGQ-RIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPN 147
+F+ VY+G ++ ++GRFCG+ P L+SS N + + S+ G GF + +P
Sbjct: 530 EFLQVYDGDSSSAFQLGRFCGSSLPHELLSSDNALYFHLYSEHLRNGRGFTVRWETQQPE 589
Query: 148 ERGDQYCGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNY 207
CGG+L P GS K+P +P +YP G CVW +V + L+ F +E +
Sbjct: 590 ------CGGILTGPYGSIKSPGYPG-NYPPGRDCVWIVVTSPDLLVTFTFGTLSLEHHDD 642
Query: 208 CRYDYVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIGHYIF 267
C DY+ + +G D +GK+C P+ + I F SD ++ GF Y+
Sbjct: 643 CNKDYLEIRDGPLYQDP-LLGKFCTTFSVPPLQTTGPFARIHFHSDSQISDQGFHITYLT 701
Query: 268 RPKKL 272
P L
Sbjct: 702 SPSDL 706
Score = 122 bits (307), Expect = 5e-28
Identities = 82/233 (35%), Positives = 115/233 (49%), Gaps = 19/233 (8%)
Query: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVD 92
CGGI SG I S +P Y N+ C+W I V V+LNF DLE + C +
Sbjct: 1510 CGGIFQAPSGEIHSPNYPSPYRSNTDCSWVIRVDRNHRVLLNFTDFDLEPQDSC----IM 1565
Query: 93 VYNGHANGQ-RIGRFCGTFR-PGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNERG 150
Y+G ++ R+ R CG + +VSSGN + ++ S + GF A F A
Sbjct: 1566 AYDGLSSTMSRLARTCGREQLANPIVSSGNSLFLRFQSGPSRQNRGFRAQFRQA------ 1619
Query: 151 DQYCGG-LLDRPSGSFKTPNWPDRDYPAGVTCVWHIVA-PKNQLIELKFEKFDVERDNYC 208
CGG +L + +P +P +YP C W I A P I L F F++ER C
Sbjct: 1620 ---CGGHILTSSFDTVSSPRFP-ANYPNNQNCSWIIQAQPPLNHITLSFTHFELERSTTC 1675
Query: 209 RYDYVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGF 261
D+V + +GG DA G+YCG P PI S + L ++F+SD S++A GF
Sbjct: 1676 ARDFVEILDGGH-EDAPLRGRYCGTDMPHPITSFSSALTLRFVSDSSISAGGF 1727
Score = 122 bits (307), Expect = 5e-28
Identities = 72/235 (30%), Positives = 118/235 (50%), Gaps = 10/235 (4%)
Query: 33 CGGILTGESGFIGSEGFPGV-YPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFV 91
CGG + G+SG + S G P + Y N C W + G + ++F +L++ + C DFV
Sbjct: 2336 CGGRVPGQSGVVESIGHPTLPYRDNLFCEWHLQGLSGHYLTISFEDFNLQNSSGCEKDFV 2395
Query: 92 DVYNGHANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNERGD 151
++++ H +G +GR+CG P ++ +S N +V+ ++D + +GF F E
Sbjct: 2396 EIWDNHTSGNILGRYCGNTIPDSIDTSSNTAVVRFVTDGSVTASGFRLRF------ESSM 2449
Query: 152 QYCGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYD 211
+ CGG L G+F +PN+P+ + P G C W I AP+ + I L F + C +
Sbjct: 2450 EECGGDLQGSIGTFTSPNYPNPN-PHGRICEWRITAPEGRRITLMFNNLRLATHPSCNNE 2508
Query: 212 YVAVFNGGEVNDARRIGKYCGD-SPPAPIVSERNELLIQFLSDLSLTADGFIGHY 265
+V VFNG N + ++ K C + I S N + + F +D S GF Y
Sbjct: 2509 HVIVFNGIRSN-SPQLEKLCSSVNVSNEIKSSGNTMKVIFFTDGSRPYGGFTASY 2562
Score = 122 bits (307), Expect = 5e-28
Identities = 69/239 (28%), Positives = 113/239 (47%), Gaps = 11/239 (4%)
Query: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVD 92
CGGI G+SG I S +P Y + C+ + P+G + L F D+E C +D V
Sbjct: 2689 CGGIQIGDSGVITSPNYPNAYDSLTHCSSLLEAPQGHTITLTFSDFDIEPHTTCAWDSVT 2748
Query: 93 VYNGHA-NGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNERGD 151
V NG + IG++CG P + S N+++V SD + G GF A ++
Sbjct: 2749 VRNGGSPESPIIGQYCGNSNPRTIQSGSNQLVVTFNSDHSLQGGGFYATWNTQTLG---- 2804
Query: 152 QYCGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEK--FDVERDNYCR 209
CGG+ +G+ ++P+WP +++P C W + K++ +E+ F+ D C+
Sbjct: 2805 --CGGIFHSDNGTIRSPHWP-QNFPENSRCSWTAITHKSKHLEISFDNNFLIPSGDGQCQ 2861
Query: 210 YDYVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIGHYIFR 268
+V V+ G E D + CG+ P P+++ N F S A GF ++ R
Sbjct: 2862 NSFVKVWAGTEEVDKALLATGCGNVAPGPVITPSNTFTAVFQSQ-EAPAQGFSASFVSR 2919
Score = 119 bits (298), Expect = 5e-27
Identities = 78/236 (33%), Positives = 120/236 (50%), Gaps = 12/236 (5%)
Query: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVD 92
CG ILT +G I S G P VYP CTW I V ++ L F LE C D+++
Sbjct: 932 CGEILTESTGTIQSPGHPNVYPHGINCTWHILVQPNHLIHLMFETFHLEFHYNCTNDYLE 991
Query: 93 VYNGHANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNERGDQ 152
VY+ + +GR+CG P +L SSGN +M+ ++D++ A GF+ + A Q
Sbjct: 992 VYDTDSE-TSLGRYCGKSIPPSLTSSGNSLMLVFVTDSDLAYEGFLINYEAISAATACLQ 1050
Query: 153 -YCGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVER--DNYCR 209
Y L G+F +PN+P+ +YP C++ I QLI + F F +E NY
Sbjct: 1051 DYTDDL-----GTFTSPNFPN-NYPNNWECIYRITVRTGQLIAVHFTNFSLEEAIGNYYT 1104
Query: 210 YDYVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIGHY 265
D++ + +GG + +G + G + P I+S N+L ++F SD T GF ++
Sbjct: 1105 -DFLEIRDGG-YEKSPLLGIFYGSNLPPTIISHSNKLWLKFKSDQIDTRSGFSAYW 1158
Score = 117 bits (294), Expect = 1e-26
Identities = 65/222 (29%), Positives = 115/222 (51%), Gaps = 10/222 (4%)
Query: 42 GFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVDVYNG-HANG 100
G + S G+P Y + CT +T P+ + L F + +E+ CR DF++V NG ++N
Sbjct: 3404 GNLRSPGWPDNYDNDKDCTVTLTAPQNHTISLFFHSLGIENSVECRNDFLEVRNGSNSNS 3463
Query: 101 QRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNERGDQYCGGLLDR 160
+G++CGT P + S N++ ++ SD+ T+ G+ +++++ CGG L
Sbjct: 3464 PLLGKYCGTLLPNPVFSQNNELYLRFKSDSVTSDRGYEIIWTSSPSG------CGGTLYG 3517
Query: 161 PSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVAVFNGGE 220
GSF +P +P YP C W +VAP +L+ + F ++ C +Y+ +++G
Sbjct: 3518 DRGSFTSPGYPG-TYPNNTYCEWVLVAPAGRLVTINFYFISIDDPGDCVQNYLTLYDGPN 3576
Query: 221 VNDARRIGKYC-GDSPPAPIVSERNELLIQFLSDLSLTADGF 261
+ G YC GD+ AP V+ N++ I+F +D + F
Sbjct: 3577 ASSPSS-GPYCGGDTSIAPFVASSNQVFIKFHADYARRPSAF 3617
Score = 114 bits (284), Expect = 2e-25
Identities = 80/248 (32%), Positives = 119/248 (47%), Gaps = 21/248 (8%)
Query: 32 TCGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFR--FIDLESDNLCRY- 88
+CGG L + G I S +P YP N C+W + V G + ++F F D+ C
Sbjct: 2091 SCGGYLHADRGIITSPKYPETYPSNLNCSWHVLVQSGLTIAVHFEQPFQIPNGDSSCNQG 2150
Query: 89 DFVDVYN---------GHANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMA 139
D++ + N G G G FCG+ L +S N+M VQ ISD + G GF
Sbjct: 2151 DYLVLRNGPDICSPPLGPPGGN--GHFCGSHASSTLFTSDNQMFVQFISDHSNEGQGFKI 2208
Query: 140 MFSAAEPNERGDQYCGGLLDRPSGSFKT-PNWPDRDYPAGVTCVWHIVAPKNQLIELKFE 198
+ A G+ Y + D S + T PN P +YP C+W + AP I+L+FE
Sbjct: 2209 KYEAKSLACGGNVY---IHDADSAGYVTSPNHP-HNYPPHADCIWILAAPPETRIQLQFE 2264
Query: 199 -KFDVERDNYCRYDYVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLT 257
+FD+E C +Y+ + +G + +DA + K+CG S P+ S + ++F SD S T
Sbjct: 2265 DRFDIEVTPNCTSNYLELRDGVD-SDAPILSKFCGTSLPSSQWSSGEVMYLRFRSDNSPT 2323
Query: 258 ADGFIGHY 265
GF Y
Sbjct: 2324 HVGFKAKY 2331
Score = 111 bits (277), Expect = 1e-24
Identities = 81/261 (31%), Positives = 122/261 (46%), Gaps = 21/261 (8%)
Query: 37 LTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVDVYNG 96
+ G G + S +P YP NS W + V VV +D+E C YD + +Y+G
Sbjct: 1856 IVGTHGKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMDIEEIQNCYYDKLRIYDG 1915
Query: 97 HA-NGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNER-----G 150
+ + + IG +CGT + + S+GN + SD++ +G GF+ + A + +
Sbjct: 1916 PSIHARLIGAYCGT-QTESFSSTGNSLTFHFYSDSSISGKGFLLEWFAVDAPDGVLPTIA 1974
Query: 151 DQYCGGLL---DRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNY 207
CGG L D P F +P WPD Y V C W I AP + +EL D+E
Sbjct: 1975 PGACGGFLRTGDAPVFLF-SPGWPD-SYSNRVDCTWLIQAP-DSTVELNILSLDIESHRT 2031
Query: 208 CRYDYVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGF------ 261
C YD + V G+ N A+++ CG P PI S + I+F SD S+T GF
Sbjct: 2032 CAYDSL-VIRDGDNNLAQQLAVLCGREIPGPIRSTGEYMFIRFTSDSSVTRAGFNASFHK 2090
Query: 262 -IGHYIFRPKKLPTTTEQPVT 281
G Y+ + + T+ + P T
Sbjct: 2091 SCGGYLHADRGIITSPKYPET 2111
Score = 110 bits (274), Expect = 3e-24
Identities = 67/242 (27%), Positives = 118/242 (48%), Gaps = 18/242 (7%)
Query: 27 ERPVFTCGGIL----TGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNF--RFIDL 80
E CGG + +G++ S P YPP++ C W + P + L F RF D+
Sbjct: 2211 EAKSLACGGNVYIHDADSAGYVTSPNHPHNYPPHADCIWILAAPPETRIQLQFEDRF-DI 2269
Query: 81 ESDNLCRYDFVDVYNG-HANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMA 139
E C +++++ +G ++ + +FCGT P + SSG M ++ SD + GF A
Sbjct: 2270 EVTPNCTSNYLELRDGVDSDAPILSKFCGTSLPSSQWSSGEVMYLRFRSDNSPTHVGFKA 2329
Query: 140 MFSAAEPNERGDQYCGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEK 199
+S A+ CGG + SG ++ P Y + C WH+ + + FE
Sbjct: 2330 KYSIAQ--------CGGRVPGQSGVVESIGHPTLPYRDNLFCEWHLQGLSGHYLTISFED 2381
Query: 200 FDVERDNYCRYDYVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTAD 259
F+++ + C D+V +++ +G+YCG++ P I + N +++F++D S+TA
Sbjct: 2382 FNLQNSSGCEKDFVEIWDNH--TSGNILGRYCGNTIPDSIDTSSNTAVVRFVTDGSVTAS 2439
Query: 260 GF 261
GF
Sbjct: 2440 GF 2441
Score = 110 bits (274), Expect = 3e-24
Identities = 75/242 (30%), Positives = 117/242 (48%), Gaps = 14/242 (5%)
Query: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVD 92
CGG L G G S +P P C W+IT PEG+ + L F + L + C + V
Sbjct: 2452 CGGDLQGSIGTFTSPNYPNPNPHGRICEWRITAPEGRRITLMFNNLRLATHPSCNNEHVI 2511
Query: 93 VYNG-HANGQRIGRFCGTFR-PGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNERG 150
V+NG +N ++ + C + + SSGN M V +D + GF A ++++E
Sbjct: 2512 VFNGIRSNSPQLEKLCSSVNVSNEIKSSGNTMKVIFFTDGSRPYGGFTASYTSSE----- 2566
Query: 151 DQYCGGLL-DRPSGSFKTPNWPD-RDYPAGVTCVWHIVAPK--NQLIELKFEKFDVERDN 206
D CGG L + P G+F +P + R+Y + C W + P N I + FE F +E
Sbjct: 2567 DAVCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSISIHFEDFYLESHQ 2626
Query: 207 YCRYDYVAVFNGGEVNDARRIGKYCGDSPPA-PIVSERNELLIQFLSDLSLTADGFIGHY 265
C++D V F G+ D + + CG S P P+V +++ I F+++ + GF Y
Sbjct: 2627 DCQFD-VLEFRVGDA-DGPLMWRLCGPSKPTLPLVIPYSQVWIHFVTNERVEHIGFHAKY 2684
Query: 266 IF 267
F
Sbjct: 2685 SF 2686
Score = 109 bits (273), Expect = 4e-24
Identities = 78/236 (33%), Positives = 116/236 (49%), Gaps = 18/236 (7%)
Query: 33 CGGIL--TGESGFIGSEGFPGV--YPPNSKCTWKITVPE--GKVVVLNFRFIDLESDNLC 86
CGG L T E F S G+ GV Y N C W ++ P + ++F LES C
Sbjct: 2570 CGGSLPNTPEGNFT-SPGYDGVRNYSRNLNCEWTLSNPNQGNSSISIHFEDFYLESHQDC 2628
Query: 87 RYDFVDVYNGHANGQRIGRFCGTFRPG-ALVSSGNKMMVQMISDANTAGNGFMAMFSAAE 145
++D ++ G A+G + R CG +P LV +++ + +++ GF A +S +
Sbjct: 2629 QFDVLEFRVGDADGPLMWRLCGPSKPTLPLVIPYSQVWIHFVTNERVEHIGFHAKYSFTD 2688
Query: 146 PNERGDQYCGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERD 205
CGG+ SG +PN+P+ Y + C + AP+ I L F FD+E
Sbjct: 2689 --------CGGIQIGDSGVITSPNYPNA-YDSLTHCSSLLEAPQGHTITLTFSDFDIEPH 2739
Query: 206 NYCRYDYVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGF 261
C +D V V NGG ++ IG+YCG+S P I S N+L++ F SD SL GF
Sbjct: 2740 TTCAWDSVTVRNGGS-PESPIIGQYCGNSNPRTIQSGSNQLVVTFNSDHSLQGGGF 2794
Score = 109 bits (272), Expect = 5e-24
Identities = 79/272 (29%), Positives = 121/272 (44%), Gaps = 23/272 (8%)
Query: 3 GANAWAPLCLLLAAATQLSRQQSPERP--------VFTCGGILTGESGFIGSEGFPGVYP 54
G AP ++ + T + QS E P V CG TG SG+I S +P Y
Sbjct: 2882 GCGNVAPGPVITPSNTFTAVFQSQEAPAQGFSASFVSRCGSNFTGPSGYIISPNYPKQYD 2941
Query: 55 PNSKCTWKITVPEGKVVVLNFRFIDLESDNL----CRYDFVDVYNGHA-NGQRIGRFCGT 109
N CT+ I VV+L F LE+ + C D V + G++ CG
Sbjct: 2942 NNMNCTYVIEANPLSVVLLTFVSFHLEARSAVTGSCVNDGVHIIRGYSVMSTPFATVCGD 3001
Query: 110 FRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNERGDQYCGGLLDRPSGSFKTPN 169
P L +G +++ S+ GF + CGG+ + SG +P
Sbjct: 3002 EMPAPLTIAG-PVLLNFYSNEQITDFGFKFSYRIIS--------CGGVFNFSSGIITSPA 3052
Query: 170 WPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVAVFNGGEVNDARRIGK 229
+ DYP + C++ I +++IELKF FDV C +DY+A+++G +D +GK
Sbjct: 3053 YSYADYPNDMHCLYTITVSDDKVIELKFSDFDVVPSTSCSHDYLAIYDGANTSDP-LLGK 3111
Query: 230 YCGDSPPAPIVSERNELLIQFLSDLSLTADGF 261
+CG P + S N +L+ F +D TA G+
Sbjct: 3112 FCGSKRPPNVKSSNNSMLLVFKTDSFQTAKGW 3143
Score = 105 bits (261), Expect = 1e-22
Identities = 68/230 (29%), Positives = 110/230 (47%), Gaps = 10/230 (4%)
Query: 38 TGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRY-DFVDVYNG 96
T + G S FP YP N +C ++ITV G+++ ++F LE Y DF+++ +G
Sbjct: 1053 TDDLGTFTSPNFPNNYPNNWECIYRITVRTGQLIAVHFTNFSLEEAIGNYYTDFLEIRDG 1112
Query: 97 -HANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNERGDQYCG 155
+ +G F G+ P ++S NK+ ++ SD +GF A + + CG
Sbjct: 1113 GYEKSPLLGIFYGSNLPPTIISHSNKLWLKFKSDQIDTRSGFSAYWDGSSTG------CG 1166
Query: 156 GLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVAV 215
G L SG+F +PN+P Y C W + + EL+F+ F +E C DY+AV
Sbjct: 1167 GNLTTSSGTFISPNYP-MPYYHSSECYWWLKSSHGSAFELEFKDFHLEHHPNCTLDYLAV 1225
Query: 216 FNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIGHY 265
++G N + + + CGD P I S + + I+ +D GF Y
Sbjct: 1226 YDGPSSN-SHLLTQLCGDEKPPLIRSSGDSMFIKLRTDEGQQGRGFKAEY 1274
Score = 97.8 bits (242), Expect = 2e-20
Identities = 67/243 (27%), Positives = 107/243 (44%), Gaps = 16/243 (6%)
Query: 24 QSPERPVFTCGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESD 83
Q PE CGGILTG G I S G+PG YPP C W + +V F + LE
Sbjct: 586 QQPE-----CGGILTGPYGSIKSPGYPGNYPPGRDCVWIVVTSPDLLVTFTFGTLSLEHH 640
Query: 84 NLCRYDFVDVYNGHA-NGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFS 142
+ C D++++ +G +G+FC TF L ++G + SD+ + GF +
Sbjct: 641 DDCNKDYLEIRDGPLYQDPLLGKFCTTFSVPPLQTTGPFARIHFHSDSQISDQGFHITYL 700
Query: 143 AAEPNERGDQYCGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDV 202
+ D CGG P G P + CV+ + P+ + I++ F ++
Sbjct: 701 TSP----SDLRCGGNYTDPEGELFLPEL-SGPFTHTRQCVYMMKQPQGEQIQINFTHVEL 755
Query: 203 ERDNYCRYDYVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFI 262
+ + +Y+ V +G + +GK CG+ + I S N + I+F D S+ F
Sbjct: 756 QCQSDSSQNYIEVRDGETL-----LGKVCGNGTISHIKSITNSVWIRFKIDASVEKASFR 810
Query: 263 GHY 265
Y
Sbjct: 811 AVY 813
Score = 96.7 bits (239), Expect = 4e-20
Identities = 65/222 (29%), Positives = 100/222 (45%), Gaps = 14/222 (6%)
Query: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVD 92
CGG LT SG S +P Y +S+C W + G L F+ LE C D++
Sbjct: 1165 CGGNLTTSSGTFISPNYPMPYYHSSECYWWLKSSHGSAFELEFKDFHLEHHPNCTLDYLA 1224
Query: 93 VYNG-HANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNERGD 151
VY+G +N + + CG +P + SSG+ M +++ +D G GF A + N
Sbjct: 1225 VYDGPSSNSHLLTQLCGDEKPPLIRSSGDSMFIKLRTDEGQQGRGFKAEYRQTCENVVIV 1284
Query: 152 QYCGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYD 211
G+L+ S PN Y C W I A + F FD+E C D
Sbjct: 1285 NQTYGILE----SIGYPN----PYSENQHCNWTIRATTGNTVNYTFLAFDLEHHINCSTD 1336
Query: 212 YVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSD 253
Y+ +++G R++G+YCG P P + ++L + L+D
Sbjct: 1337 YLELYDG-----PRQMGRYCGVDLPPPGSTTSSKLQVLLLTD 1373
Score = 91.7 bits (226), Expect = 1e-18
Identities = 64/213 (30%), Positives = 98/213 (46%), Gaps = 17/213 (7%)
Query: 33 CGGILTGESGFIGSEGFP--GVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNL---CR 87
CGG LTG + S G+Y N C W I P KV+ L F LE+ + C
Sbjct: 3157 CGGYLTGSNNTFASPDSDSNGMYDKNLNCVWIIIAPVNKVIHLTFNTFALEAASTRQRCL 3216
Query: 88 YDFVDVYNGHA-NGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEP 146
YD+V +Y+G + N G FCG+ P +SSGN + VQ ISD GF A ++
Sbjct: 3217 YDYVKLYDGDSENANLAGTFCGSTVPAPFISSGNFLTVQFISDLTLEREGFNATYTIM-- 3274
Query: 147 NERGDQYCGGLLDR--PSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVER 204
D CGG + + +PN D D P + C W I +P +Q +++ +
Sbjct: 3275 ----DMPCGGTYNATWTPQNISSPNSSDPDVPFSI-CTWVIDSPPHQQVKITVWALQLTS 3329
Query: 205 DNYCRYDYVAVFNGGEVNDARRIGKYCGDSPPA 237
+ C +Y+ + + + + R ++CG + A
Sbjct: 3330 QD-CTQNYLQLQDSPQGHGNSRF-QFCGRNASA 3360
Score = 88.2 bits (217), Expect = 1e-17
Identities = 59/233 (25%), Positives = 105/233 (45%), Gaps = 15/233 (6%)
Query: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVD 92
CGG T G + G + +C + + P+G+ + +NF ++L+ + ++++
Sbjct: 708 CGGNYTDPEGELFLPELSGPFTHTRQCVYMMKQPQGEQIQINFTHVELQCQSDSSQNYIE 767
Query: 93 VYNGHANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNERGDQ 152
V +G +G+ CG + S N + ++ DA+ F A++ A GD+
Sbjct: 768 VRDGET---LLGKVCGNGTISHIKSITNSVWIRFKIDASVEKASFRAVYQVA----CGDE 820
Query: 153 YCGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDY 212
G G ++P +P+ YP TC W I P++Q+I L F F++ +C DY
Sbjct: 821 LTG------EGVIRSPFFPN-VYPGERTCRWTIHQPQSQVILLNFTVFEIGSSAHCETDY 873
Query: 213 VAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIGHY 265
V + + + KYCG P+ I S N L + F+ S GF+ +
Sbjct: 874 VEI-GSSSILGSPENKKYCGTDIPSFITSVYNFLYVTFVKSSSTENHGFMAKF 925
Score = 71.6 bits (174), Expect = 1e-12
Identities = 34/99 (34%), Positives = 57/99 (57%), Gaps = 2/99 (2%)
Query: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVD 92
CGG L G+ G S G+PG YP N+ C W + P G++V +NF FI ++ C +++
Sbjct: 3511 CGGTLYGDRGSFTSPGYPGTYPNNTYCEWVLVAPAGRLVTINFYFISIDDPGDCVQNYLT 3570
Query: 93 VYNG-HANGQRIGRFCGTFRPGA-LVSSGNKMMVQMISD 129
+Y+G +A+ G +CG A V+S N++ ++ +D
Sbjct: 3571 LYDGPNASSPSSGPYCGGDTSIAPFVASSNQVFIKFHAD 3609
>gi|13899255 membrane frizzled-related protein [Homo sapiens]
Length = 579
Score = 143 bits (360), Expect = 3e-34
Identities = 87/292 (29%), Positives = 133/292 (45%), Gaps = 43/292 (14%)
Query: 15 AAATQLSRQQS--PERPVFTCGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVV 72
AA T +Q+S P TCGG+L+G GF S +P YPPN+ C W I V +
Sbjct: 124 AAGTPKGQQESGVSPSPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQ 183
Query: 73 LNFRFIDLESDNLCRYDFVDVYNGHANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANT 132
L + +ES C +D +++ + G + R CG P L ++ + ++V +SD++
Sbjct: 184 LKIEALSIESVASCLFDRLEL-SPEPEGPLL-RVCGRVPPPTLNTNASHLLVVFVSDSSV 241
Query: 133 AGNGFMAMFSAAEPNE--------RGDQY------------------------------C 154
G GF A + A P R DQ C
Sbjct: 242 EGFGFHAWYQAMAPGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGC 301
Query: 155 GGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVA 214
GG L G+F TP++ + YP + C WHI P IEL+F F +E + C++DYV
Sbjct: 302 GGNLTGLQGTFSTPSYL-QQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVE 360
Query: 215 VFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIGHYI 266
V+ +G++CG PP +VS +EL + F +D +++ GF Y+
Sbjct: 361 VYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYL 412
Score = 82.0 bits (201), Expect = 9e-16
Identities = 49/141 (34%), Positives = 69/141 (48%), Gaps = 6/141 (4%)
Query: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVD 92
CGG LTG G + + YP CTW I+VP G + L F LE+ + C++D+V+
Sbjct: 301 CGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVE 360
Query: 93 VYNGHANG--QRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNERG 150
VY ++G +GRFCG P LVSS +++ V +D + GF A + A E
Sbjct: 361 VYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENP 420
Query: 151 DQYCG-GLLDRPSGSFKTPNW 170
CG L +G K W
Sbjct: 421 ---CGPSELSCQAGGCKGVQW 438
>gi|66864913 neuropilin 1 isoform c [Homo sapiens]
Length = 609
Score = 141 bits (356), Expect = 1e-33
Identities = 87/243 (35%), Positives = 135/243 (55%), Gaps = 17/243 (6%)
Query: 33 CGGILTGES-GFIGSEGFPGVYPPNSKCTWKITVPEG-KVVVLNFR-FIDLESDNLCRYD 89
CG + ES G++ S G+P Y P+ KC W I P+ + +++NF DLE D C+YD
Sbjct: 27 CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLE-DRDCKYD 85
Query: 90 FVDVYNG-HANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNE 148
+V+V++G + NG G+FCG P +VSSG + ++ +SD T G GF + E +
Sbjct: 86 YVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRY---EIFK 142
Query: 149 RGDQYCGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDN-- 206
RG + C PSG K+P +P++ YP + C + + APK I L+FE FD+E D+
Sbjct: 143 RGPE-CSQNYTTPSGVIKSPGFPEK-YPNSLECTYIVFAPKMSEIILEFESFDLEPDSNP 200
Query: 207 ----YCRYDYVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFI 262
+CRYD + +++G + IG+YCG P I S L + F +D ++ +GF
Sbjct: 201 PGGMFCRYDRLEIWDGFP-DVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFS 259
Query: 263 GHY 265
+Y
Sbjct: 260 ANY 262
Score = 79.0 bits (193), Expect = 8e-15
Identities = 46/138 (33%), Positives = 69/138 (50%), Gaps = 7/138 (5%)
Query: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDN------LC 86
C T SG I S GFP YP + +CT+ + P+ ++L F DLE D+ C
Sbjct: 147 CSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFC 206
Query: 87 RYDFVDVYNGHAN-GQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAE 145
RYD +++++G + G IGR+CG PG + SS + + +D+ A GF A +S +
Sbjct: 207 RYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQ 266
Query: 146 PNERGDQYCGGLLDRPSG 163
+ D C L SG
Sbjct: 267 SSVSEDFKCMEALGMESG 284
>gi|66912178 neuropilin 1 isoform b [Homo sapiens]
Length = 644
Score = 141 bits (356), Expect = 1e-33
Identities = 87/243 (35%), Positives = 135/243 (55%), Gaps = 17/243 (6%)
Query: 33 CGGILTGES-GFIGSEGFPGVYPPNSKCTWKITVPEG-KVVVLNFR-FIDLESDNLCRYD 89
CG + ES G++ S G+P Y P+ KC W I P+ + +++NF DLE D C+YD
Sbjct: 27 CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLE-DRDCKYD 85
Query: 90 FVDVYNG-HANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNE 148
+V+V++G + NG G+FCG P +VSSG + ++ +SD T G GF + E +
Sbjct: 86 YVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRY---EIFK 142
Query: 149 RGDQYCGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDN-- 206
RG + C PSG K+P +P++ YP + C + + APK I L+FE FD+E D+
Sbjct: 143 RGPE-CSQNYTTPSGVIKSPGFPEK-YPNSLECTYIVFAPKMSEIILEFESFDLEPDSNP 200
Query: 207 ----YCRYDYVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFI 262
+CRYD + +++G + IG+YCG P I S L + F +D ++ +GF
Sbjct: 201 PGGMFCRYDRLEIWDGFP-DVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFS 259
Query: 263 GHY 265
+Y
Sbjct: 260 ANY 262
Score = 79.0 bits (193), Expect = 8e-15
Identities = 46/138 (33%), Positives = 69/138 (50%), Gaps = 7/138 (5%)
Query: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDN------LC 86
C T SG I S GFP YP + +CT+ + P+ ++L F DLE D+ C
Sbjct: 147 CSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFC 206
Query: 87 RYDFVDVYNGHAN-GQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAE 145
RYD +++++G + G IGR+CG PG + SS + + +D+ A GF A +S +
Sbjct: 207 RYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQ 266
Query: 146 PNERGDQYCGGLLDRPSG 163
+ D C L SG
Sbjct: 267 SSVSEDFKCMEALGMESG 284
>gi|182508169 neuropilin 1 isoform a [Homo sapiens]
Length = 923
Score = 141 bits (356), Expect = 1e-33
Identities = 87/243 (35%), Positives = 135/243 (55%), Gaps = 17/243 (6%)
Query: 33 CGGILTGES-GFIGSEGFPGVYPPNSKCTWKITVPEG-KVVVLNFR-FIDLESDNLCRYD 89
CG + ES G++ S G+P Y P+ KC W I P+ + +++NF DLE D C+YD
Sbjct: 27 CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLE-DRDCKYD 85
Query: 90 FVDVYNG-HANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNE 148
+V+V++G + NG G+FCG P +VSSG + ++ +SD T G GF + E +
Sbjct: 86 YVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRY---EIFK 142
Query: 149 RGDQYCGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDN-- 206
RG + C PSG K+P +P++ YP + C + + APK I L+FE FD+E D+
Sbjct: 143 RGPE-CSQNYTTPSGVIKSPGFPEK-YPNSLECTYIVFAPKMSEIILEFESFDLEPDSNP 200
Query: 207 ----YCRYDYVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFI 262
+CRYD + +++G + IG+YCG P I S L + F +D ++ +GF
Sbjct: 201 PGGMFCRYDRLEIWDGFP-DVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFS 259
Query: 263 GHY 265
+Y
Sbjct: 260 ANY 262
Score = 79.0 bits (193), Expect = 8e-15
Identities = 46/138 (33%), Positives = 69/138 (50%), Gaps = 7/138 (5%)
Query: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDN------LC 86
C T SG I S GFP YP + +CT+ + P+ ++L F DLE D+ C
Sbjct: 147 CSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMFC 206
Query: 87 RYDFVDVYNGHAN-GQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAE 145
RYD +++++G + G IGR+CG PG + SS + + +D+ A GF A +S +
Sbjct: 207 RYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQ 266
Query: 146 PNERGDQYCGGLLDRPSG 163
+ D C L SG
Sbjct: 267 SSVSEDFKCMEALGMESG 284
>gi|41872572 neuropilin 2 isoform 3 precursor [Homo sapiens]
Length = 909
Score = 131 bits (329), Expect = 1e-30
Identities = 80/259 (30%), Positives = 136/259 (52%), Gaps = 16/259 (6%)
Query: 17 ATQLSRQQSPERPVFTCGGILTG-ESGFIGSEGFPGVYPPNSKCTWKITVPE-GKVVVLN 74
A SR Q +P CGG L ++G+I S G+P YP + C W + PE + +VLN
Sbjct: 12 ALYFSRHQVRGQPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLN 71
Query: 75 FR-FIDLESDNLCRYDFVDVYNGHA-NGQRIGRFCGTFRPGALVSSGNKMMVQMISDANT 132
F ++E + C+YDF+++ +G + + +G+ CG P ++SSG+ + ++ SD
Sbjct: 72 FNPHFEIEKHD-CKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYAR 130
Query: 133 AGNGFMAMFSAAEPNERGDQYCGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQL 192
G GF + E + G + C P+G+ ++P +P++ YP + C + I+A
Sbjct: 131 QGAGFSLRY---EIFKTGSEDCSKNFTSPNGTIESPGFPEK-YPHNLDCTFTILAKPKME 186
Query: 193 IELKFEKFDVERDNY------CRYDYVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNEL 246
I L+F FD+E D C+YD++ +++G + IGKYCG P+ + S L
Sbjct: 187 IILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIP-HVGPLIGKYCGTKTPSELRSSTGIL 245
Query: 247 LIQFLSDLSLTADGFIGHY 265
+ F +D+++ DGF Y
Sbjct: 246 SLTFHTDMAVAKDGFSARY 264
Score = 71.6 bits (174), Expect = 1e-12
Identities = 45/138 (32%), Positives = 64/138 (46%), Gaps = 7/138 (5%)
Query: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNL------C 86
C T +G I S GFP YP N CT+ I ++L F DLE D L C
Sbjct: 149 CSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDC 208
Query: 87 RYDFVDVYNGHAN-GQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAE 145
+YD++D+++G + G IG++CGT P L SS + + +D A +GF A +
Sbjct: 209 KYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYYLVH 268
Query: 146 PNERGDQYCGGLLDRPSG 163
+ C L SG
Sbjct: 269 QEPLENFQCNVPLGMESG 286
>gi|41872567 neuropilin 2 isoform 5 precursor [Homo sapiens]
Length = 901
Score = 131 bits (329), Expect = 1e-30
Identities = 80/259 (30%), Positives = 136/259 (52%), Gaps = 16/259 (6%)
Query: 17 ATQLSRQQSPERPVFTCGGILTG-ESGFIGSEGFPGVYPPNSKCTWKITVPE-GKVVVLN 74
A SR Q +P CGG L ++G+I S G+P YP + C W + PE + +VLN
Sbjct: 12 ALYFSRHQVRGQPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLN 71
Query: 75 FR-FIDLESDNLCRYDFVDVYNGHA-NGQRIGRFCGTFRPGALVSSGNKMMVQMISDANT 132
F ++E + C+YDF+++ +G + + +G+ CG P ++SSG+ + ++ SD
Sbjct: 72 FNPHFEIEKHD-CKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYAR 130
Query: 133 AGNGFMAMFSAAEPNERGDQYCGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQL 192
G GF + E + G + C P+G+ ++P +P++ YP + C + I+A
Sbjct: 131 QGAGFSLRY---EIFKTGSEDCSKNFTSPNGTIESPGFPEK-YPHNLDCTFTILAKPKME 186
Query: 193 IELKFEKFDVERDNY------CRYDYVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNEL 246
I L+F FD+E D C+YD++ +++G + IGKYCG P+ + S L
Sbjct: 187 IILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIP-HVGPLIGKYCGTKTPSELRSSTGIL 245
Query: 247 LIQFLSDLSLTADGFIGHY 265
+ F +D+++ DGF Y
Sbjct: 246 SLTFHTDMAVAKDGFSARY 264
Score = 71.6 bits (174), Expect = 1e-12
Identities = 45/138 (32%), Positives = 64/138 (46%), Gaps = 7/138 (5%)
Query: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNL------C 86
C T +G I S GFP YP N CT+ I ++L F DLE D L C
Sbjct: 149 CSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDC 208
Query: 87 RYDFVDVYNGHAN-GQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAE 145
+YD++D+++G + G IG++CGT P L SS + + +D A +GF A +
Sbjct: 209 KYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYYLVH 268
Query: 146 PNERGDQYCGGLLDRPSG 163
+ C L SG
Sbjct: 269 QEPLENFQCNVPLGMESG 286
>gi|41872562 neuropilin 2 isoform 1 precursor [Homo sapiens]
Length = 931
Score = 131 bits (329), Expect = 1e-30
Identities = 80/259 (30%), Positives = 136/259 (52%), Gaps = 16/259 (6%)
Query: 17 ATQLSRQQSPERPVFTCGGILTG-ESGFIGSEGFPGVYPPNSKCTWKITVPE-GKVVVLN 74
A SR Q +P CGG L ++G+I S G+P YP + C W + PE + +VLN
Sbjct: 12 ALYFSRHQVRGQPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLN 71
Query: 75 FR-FIDLESDNLCRYDFVDVYNGHA-NGQRIGRFCGTFRPGALVSSGNKMMVQMISDANT 132
F ++E + C+YDF+++ +G + + +G+ CG P ++SSG+ + ++ SD
Sbjct: 72 FNPHFEIEKHD-CKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYAR 130
Query: 133 AGNGFMAMFSAAEPNERGDQYCGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQL 192
G GF + E + G + C P+G+ ++P +P++ YP + C + I+A
Sbjct: 131 QGAGFSLRY---EIFKTGSEDCSKNFTSPNGTIESPGFPEK-YPHNLDCTFTILAKPKME 186
Query: 193 IELKFEKFDVERDNY------CRYDYVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNEL 246
I L+F FD+E D C+YD++ +++G + IGKYCG P+ + S L
Sbjct: 187 IILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIP-HVGPLIGKYCGTKTPSELRSSTGIL 245
Query: 247 LIQFLSDLSLTADGFIGHY 265
+ F +D+++ DGF Y
Sbjct: 246 SLTFHTDMAVAKDGFSARY 264
Score = 71.6 bits (174), Expect = 1e-12
Identities = 45/138 (32%), Positives = 64/138 (46%), Gaps = 7/138 (5%)
Query: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNL------C 86
C T +G I S GFP YP N CT+ I ++L F DLE D L C
Sbjct: 149 CSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDC 208
Query: 87 RYDFVDVYNGHAN-GQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAE 145
+YD++D+++G + G IG++CGT P L SS + + +D A +GF A +
Sbjct: 209 KYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYYLVH 268
Query: 146 PNERGDQYCGGLLDRPSG 163
+ C L SG
Sbjct: 269 QEPLENFQCNVPLGMESG 286
>gi|41872557 neuropilin 2 isoform 6 precursor [Homo sapiens]
Length = 555
Score = 131 bits (329), Expect = 1e-30
Identities = 80/259 (30%), Positives = 136/259 (52%), Gaps = 16/259 (6%)
Query: 17 ATQLSRQQSPERPVFTCGGILTG-ESGFIGSEGFPGVYPPNSKCTWKITVPE-GKVVVLN 74
A SR Q +P CGG L ++G+I S G+P YP + C W + PE + +VLN
Sbjct: 12 ALYFSRHQVRGQPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLN 71
Query: 75 FR-FIDLESDNLCRYDFVDVYNGHA-NGQRIGRFCGTFRPGALVSSGNKMMVQMISDANT 132
F ++E + C+YDF+++ +G + + +G+ CG P ++SSG+ + ++ SD
Sbjct: 72 FNPHFEIEKHD-CKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYAR 130
Query: 133 AGNGFMAMFSAAEPNERGDQYCGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQL 192
G GF + E + G + C P+G+ ++P +P++ YP + C + I+A
Sbjct: 131 QGAGFSLRY---EIFKTGSEDCSKNFTSPNGTIESPGFPEK-YPHNLDCTFTILAKPKME 186
Query: 193 IELKFEKFDVERDNY------CRYDYVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNEL 246
I L+F FD+E D C+YD++ +++G + IGKYCG P+ + S L
Sbjct: 187 IILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIP-HVGPLIGKYCGTKTPSELRSSTGIL 245
Query: 247 LIQFLSDLSLTADGFIGHY 265
+ F +D+++ DGF Y
Sbjct: 246 SLTFHTDMAVAKDGFSARY 264
Score = 71.6 bits (174), Expect = 1e-12
Identities = 45/138 (32%), Positives = 64/138 (46%), Gaps = 7/138 (5%)
Query: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNL------C 86
C T +G I S GFP YP N CT+ I ++L F DLE D L C
Sbjct: 149 CSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDC 208
Query: 87 RYDFVDVYNGHAN-GQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAE 145
+YD++D+++G + G IG++CGT P L SS + + +D A +GF A +
Sbjct: 209 KYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYYLVH 268
Query: 146 PNERGDQYCGGLLDRPSG 163
+ C L SG
Sbjct: 269 QEPLENFQCNVPLGMESG 286
>gi|41872544 neuropilin 2 isoform 4 precursor [Homo sapiens]
Length = 906
Score = 131 bits (329), Expect = 1e-30
Identities = 80/259 (30%), Positives = 136/259 (52%), Gaps = 16/259 (6%)
Query: 17 ATQLSRQQSPERPVFTCGGILTG-ESGFIGSEGFPGVYPPNSKCTWKITVPE-GKVVVLN 74
A SR Q +P CGG L ++G+I S G+P YP + C W + PE + +VLN
Sbjct: 12 ALYFSRHQVRGQPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLN 71
Query: 75 FR-FIDLESDNLCRYDFVDVYNGHA-NGQRIGRFCGTFRPGALVSSGNKMMVQMISDANT 132
F ++E + C+YDF+++ +G + + +G+ CG P ++SSG+ + ++ SD
Sbjct: 72 FNPHFEIEKHD-CKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYAR 130
Query: 133 AGNGFMAMFSAAEPNERGDQYCGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQL 192
G GF + E + G + C P+G+ ++P +P++ YP + C + I+A
Sbjct: 131 QGAGFSLRY---EIFKTGSEDCSKNFTSPNGTIESPGFPEK-YPHNLDCTFTILAKPKME 186
Query: 193 IELKFEKFDVERDNY------CRYDYVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNEL 246
I L+F FD+E D C+YD++ +++G + IGKYCG P+ + S L
Sbjct: 187 IILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIP-HVGPLIGKYCGTKTPSELRSSTGIL 245
Query: 247 LIQFLSDLSLTADGFIGHY 265
+ F +D+++ DGF Y
Sbjct: 246 SLTFHTDMAVAKDGFSARY 264
Score = 71.6 bits (174), Expect = 1e-12
Identities = 45/138 (32%), Positives = 64/138 (46%), Gaps = 7/138 (5%)
Query: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNL------C 86
C T +G I S GFP YP N CT+ I ++L F DLE D L C
Sbjct: 149 CSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDC 208
Query: 87 RYDFVDVYNGHAN-GQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAE 145
+YD++D+++G + G IG++CGT P L SS + + +D A +GF A +
Sbjct: 209 KYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYYLVH 268
Query: 146 PNERGDQYCGGLLDRPSG 163
+ C L SG
Sbjct: 269 QEPLENFQCNVPLGMESG 286
>gi|41872533 neuropilin 2 isoform 2 precursor [Homo sapiens]
Length = 926
Score = 131 bits (329), Expect = 1e-30
Identities = 80/259 (30%), Positives = 136/259 (52%), Gaps = 16/259 (6%)
Query: 17 ATQLSRQQSPERPVFTCGGILTG-ESGFIGSEGFPGVYPPNSKCTWKITVPE-GKVVVLN 74
A SR Q +P CGG L ++G+I S G+P YP + C W + PE + +VLN
Sbjct: 12 ALYFSRHQVRGQPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLN 71
Query: 75 FR-FIDLESDNLCRYDFVDVYNGHA-NGQRIGRFCGTFRPGALVSSGNKMMVQMISDANT 132
F ++E + C+YDF+++ +G + + +G+ CG P ++SSG+ + ++ SD
Sbjct: 72 FNPHFEIEKHD-CKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYAR 130
Query: 133 AGNGFMAMFSAAEPNERGDQYCGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQL 192
G GF + E + G + C P+G+ ++P +P++ YP + C + I+A
Sbjct: 131 QGAGFSLRY---EIFKTGSEDCSKNFTSPNGTIESPGFPEK-YPHNLDCTFTILAKPKME 186
Query: 193 IELKFEKFDVERDNY------CRYDYVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNEL 246
I L+F FD+E D C+YD++ +++G + IGKYCG P+ + S L
Sbjct: 187 IILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIP-HVGPLIGKYCGTKTPSELRSSTGIL 245
Query: 247 LIQFLSDLSLTADGFIGHY 265
+ F +D+++ DGF Y
Sbjct: 246 SLTFHTDMAVAKDGFSARY 264
Score = 71.6 bits (174), Expect = 1e-12
Identities = 45/138 (32%), Positives = 64/138 (46%), Gaps = 7/138 (5%)
Query: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNL------C 86
C T +G I S GFP YP N CT+ I ++L F DLE D L C
Sbjct: 149 CSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDC 208
Query: 87 RYDFVDVYNGHAN-GQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAE 145
+YD++D+++G + G IG++CGT P L SS + + +D A +GF A +
Sbjct: 209 KYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYYLVH 268
Query: 146 PNERGDQYCGGLLDRPSG 163
+ C L SG
Sbjct: 269 QEPLENFQCNVPLGMESG 286
>gi|148231605 ovochymase 2 [Homo sapiens]
Length = 564
Score = 116 bits (290), Expect = 4e-26
Identities = 76/244 (31%), Positives = 119/244 (48%), Gaps = 18/244 (7%)
Query: 41 SGFIGSEGFPG----VYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVDVYNG 96
SG G FP Y +C W + VPE V+L+F +D+ES C + ++ +Y+
Sbjct: 319 SGAEGKLHFPESLHLYYESKQRCVWTLLVPEEMHVLLSFSHLDVES---CHHSYLSMYS- 374
Query: 97 HANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNERGDQYCGG 156
+ IG+FCG P +++ N + ++ +SDA GF + A +PN D C
Sbjct: 375 -LEDRPIGKFCGESLPSSILIGSNSLRLKFVSDATDNAAGFNLTYKALKPNYIPDSGCSY 433
Query: 157 L-LDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVAV 215
L + G ++ N+P+ +Y C W A K+ LI+L F+ ++E C DYV V
Sbjct: 434 LTVLFEEGLIQSLNYPE-NYSDKANCDWIFQASKHHLIKLSFQSLEIEESGDCTSDYVTV 492
Query: 216 FNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIGHYIFRPK----- 270
+ +V + I + CG P P++S + +LI F SD + T GF F PK
Sbjct: 493 HS--DVERKKEIARLCGYDVPTPVLSPSSIMLISFQSDENGTCRGFQATVSFIPKAGKKI 550
Query: 271 KLPT 274
+LPT
Sbjct: 551 ELPT 554
Score = 55.8 bits (133), Expect = 7e-08
Identities = 29/103 (28%), Positives = 48/103 (46%)
Query: 40 ESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVDVYNGHAN 99
E G I S +P Y + C W + ++ L+F+ +++E C D+V V++
Sbjct: 439 EEGLIQSLNYPENYSDKANCDWIFQASKHHLIKLSFQSLEIEESGDCTSDYVTVHSDVER 498
Query: 100 GQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFS 142
+ I R CG P ++S + M++ SD N GF A S
Sbjct: 499 KKEIARLCGYDVPTPVLSPSSIMLISFQSDENGTCRGFQATVS 541
>gi|30520377 CUB and zona pellucida-like domains 1 [Homo sapiens]
Length = 607
Score = 108 bits (271), Expect = 7e-24
Identities = 65/214 (30%), Positives = 107/214 (50%), Gaps = 8/214 (3%)
Query: 55 PNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVDVYNG-HANGQRIGRFCGT--FR 111
P+ CTW I PE K + + F ++ L+ D C + + V++G +NG +G+ C +
Sbjct: 54 PSENCTWTIERPENKSIRIIFSYVQLDPDGSCESENIKVFDGTSSNGPLLGQVCSKNDYV 113
Query: 112 PGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNERGDQYCGGLLDRPSGSFKTPNWP 171
P SS + + Q+++D+ + PN CGG LD GSF +PN+P
Sbjct: 114 P-VFESSSSTLTFQIVTDSARIQRTVFVFYYFFSPNISIPN-CGGYLDTLEGSFTSPNYP 171
Query: 172 DRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVAVFNGGEVNDARRIGKYC 231
+ +P CVWHI K+ I+L F++ +E D C++D++A+++G N IG+ C
Sbjct: 172 -KPHPELAYCVWHIQVEKDYKIKLNFKEIFLEIDKQCKFDFLAIYDGPSTNSG-LIGQVC 229
Query: 232 GDSPPAPIVSERNELLIQFLSDLSLTADGFIGHY 265
G P S N L + +D + + GF Y
Sbjct: 230 GRVTPT-FESSSNSLTVVLSTDYANSYRGFSASY 262
Score = 70.5 bits (171), Expect = 3e-12
Identities = 40/120 (33%), Positives = 60/120 (50%), Gaps = 2/120 (1%)
Query: 25 SPERPVFTCGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDN 84
SP + CGG L G S +P +P + C W I V + + LNF+ I LE D
Sbjct: 146 SPNISIPNCGGYLDTLEGSFTSPNYPKPHPELAYCVWHIQVEKDYKIKLNFKEIFLEIDK 205
Query: 85 LCRYDFVDVYNG-HANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSA 143
C++DF+ +Y+G N IG+ CG P SS N + V + +D + GF A +++
Sbjct: 206 QCKFDFLAIYDGPSTNSGLIGQVCGRVTP-TFESSSNSLTVVLSTDYANSYRGFSASYTS 264
>gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens]
Length = 3565
Score = 101 bits (252), Expect = 1e-21
Identities = 78/297 (26%), Positives = 127/297 (42%), Gaps = 65/297 (21%)
Query: 30 VFTCGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYD 89
+ TCGG L+ G I S GFPG YP N CTW+I++P G + F E++ +D
Sbjct: 1972 IATCGGTLSTLGGVILSPGFPGSYPNNLDCTWRISLPIGYGAHIQFLNFSTEAN----HD 2027
Query: 90 FVDVYNG-HANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAE--- 145
F+++ NG + IG+F GT P AL+S+ ++ ++ SD + GF + A E
Sbjct: 2028 FLEIQNGPYHTSPMIGQFSGTDLPAALLSTTHETLIHFYSDHSQNRQGFKLAYQAYELQN 2087
Query: 146 -----PNERG----------------------------------------------DQYC 154
P + G D C
Sbjct: 2088 CPDPPPFQNGYMINSDYSVGQSVSFECYPGYILIGHPVLTCQHGINRNWNYPFPRCDAPC 2147
Query: 155 GGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVA 214
G + +G+ +P +PD +YP C+W I P + + F E N DY+A
Sbjct: 2148 GYNVTSQNGTIYSPGFPD-EYPILKDCIWLITVPPGHGVYINFTLLQTEAVN----DYIA 2202
Query: 215 VFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIGHYIFRPKK 271
V++G + N + ++G + G++ S N++L++F SD S + + F+ KK
Sbjct: 2203 VWDGPDQN-SPQLGVFSGNTALETAYSSTNQVLLKFHSDFSNGGFFVLNFHAFQLKK 2258
Score = 90.5 bits (223), Expect = 3e-18
Identities = 78/296 (26%), Positives = 120/296 (40%), Gaps = 67/296 (22%)
Query: 33 CGG-ILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFV 91
CGG I SG I S G+P Y N CTW I GK + L+F D E +D +
Sbjct: 1278 CGGQIHAATSGRILSPGYPAPYDNNLHCTWIIEADPGKTISLHFIVFDTE----MAHDIL 1333
Query: 92 DVYNGHANGQ-RIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAA------ 144
V++G + + + G+ P + S+ N + +Q SD + +GF FS +
Sbjct: 1334 KVWDGPVDSDILLKEWSGSALPEDIHSTFNSLTLQFDSDFFISKSGFSIQFSTSIAATCN 1393
Query: 145 ------------EPNERGDQY-------------------------------------CG 155
+ E GD CG
Sbjct: 1394 DPGMPQNGTRYGDSREAGDTVTFQCDPGYQLQGQAKITCVQLNNRFFWQPDPPTCIAACG 1453
Query: 156 GLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVAV 215
G L P+G +PN+P + YP G C W + + +I L F+ F++E YD++ +
Sbjct: 1454 GNLTGPAGVILSPNYP-QPYPPGKECDWRVKVNPDFVIALIFKSFNMEPS----YDFLHI 1508
Query: 216 FNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIGHYIFRPKK 271
+ GE +++ IG Y G P I S N L + F SD S+ GF + +P++
Sbjct: 1509 YE-GEDSNSPLIGSYQGSQAPERIESSGNSLFLAFRSDASVGLSGFAIEFKEKPRE 1563
Score = 86.3 bits (212), Expect = 5e-17
Identities = 74/287 (25%), Positives = 111/287 (38%), Gaps = 65/287 (22%)
Query: 30 VFTCGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYD 89
V C G T G I S G+P Y N C WKI V EG + + E + +D
Sbjct: 1800 VVPCSGNFTQRRGTILSPGYPEPYGNNLNCIWKIIVTEGSGIQIQVISFATEQN----WD 1855
Query: 90 FVDVYN-GHANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGF------MAMFS 142
+++++ G R+G F GT P L S+ N++ + SD + A GF + + +
Sbjct: 1856 SLEIHDGGDVTAPRLGSFSGTTVPALLNSTSNQLYLHFQSDISVAAAGFHLEYKTVGLAA 1915
Query: 143 AAEPN------ERGDQY------------------------------------------C 154
EP + GD+Y C
Sbjct: 1916 CQEPALPSNSIKIGDRYMVNDVLSFQCEPGYTLQGRSHISCMPGTVRRWNYPSPLCIATC 1975
Query: 155 GGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVA 214
GG L G +P +P YP + C W I P ++F F E +D++
Sbjct: 1976 GGTLSTLGGVILSPGFPG-SYPNNLDCTWRISLPIGYGAHIQFLNFSTE----ANHDFLE 2030
Query: 215 VFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGF 261
+ N G + + IG++ G PA ++S +E LI F SD S GF
Sbjct: 2031 IQN-GPYHTSPMIGQFSGTDLPAALLSTTHETLIHFYSDHSQNRQGF 2076
Score = 80.9 bits (198), Expect = 2e-15
Identities = 78/316 (24%), Positives = 131/316 (41%), Gaps = 79/316 (25%)
Query: 23 QQSPERPVFTCGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLES 82
Q P + CGG LTG +G I S +P YPP +C W++ V V+ L F+ ++E
Sbjct: 1442 QPDPPTCIAACGGNLTGPAGVILSPNYPQPYPPGKECDWRVKVNPDFVIALIFKSFNMEP 1501
Query: 83 DNLCRYDFVDVYNGH-ANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMF 141
YDF+ +Y G +N IG + G+ P + SSGN + + SDA+ +GF F
Sbjct: 1502 S----YDFLHIYEGEDSNSPLIGSYQGSQAPERIESSGNSLFLAFRSDASVGLSGFAIEF 1557
Query: 142 SAAEPNER-------------GDQYCGG------------LLDRPS-----GSFKTPNWP 171
+P E G + G +LD S G+ P+W
Sbjct: 1558 K-EKPREACFDPGNIMNGTRVGTDFKLGSTITYQCDSGYKILDPSSITCVIGADGKPSWD 1616
Query: 172 D--------------------------RDYPAGVTCVWHIVAPKNQLIELKFEKFDVERD 205
+Y AG C++ I PK ++ +F F +
Sbjct: 1617 QVLPSCNAPCGGQYTGSEGVVLSPNYPHNYTAGQICLYSITVPKEFVVFGQFAYFQTALN 1676
Query: 206 NYCRYDYVAVFNGGEVNDARRI----GKYCGDSPPAPIVSERNELLIQFLSDLSLTADGF 261
D +F+G AR + G + G++ P ++ N++L++F + +A GF
Sbjct: 1677 -----DLAELFDGTHA-QARLLSSLSGSHSGETLP---LATSNQILLRFSAKSGASARGF 1727
Query: 262 IGHYIFRPKKLPTTTE 277
H+++ + +P T++
Sbjct: 1728 --HFVY--QAVPRTSD 1739
Score = 78.6 bits (192), Expect = 1e-14
Identities = 79/306 (25%), Positives = 119/306 (38%), Gaps = 69/306 (22%)
Query: 19 QLSRQQSPERP--VFTCGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFR 76
Q + Q S +P VF+C T SG I S +P Y N C W I G + L F
Sbjct: 569 QQNNQWSGNKPSCVFSCFFNFTASSGIILSPNYPEEYGNNMNCVWLIISEPGSRIHLIFN 628
Query: 77 FIDLESDNLCRYDFVDVY-NGHANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGN 135
D+E ++DF+ V +G ++ +G F G P L SSG+ + ++ SD +T G
Sbjct: 629 DFDVEP----QFDFLAVKDDGISDITVLGTFSGNEVPSQLASSGHIVRLEFQSDHSTTGR 684
Query: 136 GFMAMFSAAEPNE------------RGDQYCGG--------------------------- 156
GF ++ NE GD++ G
Sbjct: 685 GFNITYTTFGQNECHDPGIPINGRRFGDRFLLGSSVSFHCDDGFVKTQGSESITCILQDG 744
Query: 157 ---------LLDRPSGSFKT--------PNWPDRDYPAGVTCVWHIVAPKNQLIELKFEK 199
+ P G T P WP Y + C W I A I++ F++
Sbjct: 745 NVVWSSTVPRCEAPCGGHLTASSGVILPPGWPGY-YKDSLHCEWIIEAKPGHSIKITFDR 803
Query: 200 FDVERDNYCRYDYVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTAD 259
F E YD + V G + + IG+Y G P ++S N + + F +D S ++
Sbjct: 804 FQTE----VNYDTLEV-RDGPASSSPLIGEYHGTQAPQFLISTGNFMYLLFTTDNSRSSI 858
Query: 260 GFIGHY 265
GF+ HY
Sbjct: 859 GFLIHY 864
Score = 77.0 bits (188), Expect = 3e-14
Identities = 71/286 (24%), Positives = 112/286 (39%), Gaps = 67/286 (23%)
Query: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVD 92
CGG LT SG I G+PG Y + C W I G + + F E YD ++
Sbjct: 759 CGGHLTASSGVILPPGWPGYYKDSLHCEWIIEAKPGHSIKITFDRFQTE----VNYDTLE 814
Query: 93 VYNGHANGQ-RIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMF--------SA 143
V +G A+ IG + GT P L+S+GN M + +D + + GF+ + S
Sbjct: 815 VRDGPASSSPLIGEYHGTQAPQFLISTGNFMYLLFTTDNSRSSIGFLIHYESVTLESDSC 874
Query: 144 AEPN------------------------------------ERGDQY----------CGGL 157
+P ER Q+ CGG
Sbjct: 875 LDPGIPVNGHRHGGDFGIRSTVTFSCDPGYTLSDDEPLVCERNHQWNHALPSCDALCGGY 934
Query: 158 LDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVAVFN 217
+ SG+ +P +PD YP + C W I + +++ F F +E +DY+ +
Sbjct: 935 IQGKSGTVLSPGFPD-FYPNSLNCTWTIEVSHGKGVQMIFHTFHLESS----HDYLLITE 989
Query: 218 GGEVND--ARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGF 261
G ++ AR G + A + L +F+SD S++ +GF
Sbjct: 990 DGSFSEPVARLTGSVLPHTIKAGLFGNFTAQL-RFISDFSISYEGF 1034
Score = 76.6 bits (187), Expect = 4e-14
Identities = 76/295 (25%), Positives = 114/295 (38%), Gaps = 67/295 (22%)
Query: 25 SPERPVF---TCGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPE-GKVVVLNFRFIDL 80
S RP+ TCG L G SG I S +P Y N+ C W IT + KV+ L F +L
Sbjct: 401 SDHRPICRARTCGSNLRGPSGVITSPNYPVQYEDNAHCVWVITTTDPDKVIKLAFEEFEL 460
Query: 81 ESDNLCRYDFVDVYNGHANGQR---IGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGF 137
E YD + V + G + G+ P +VS N+M + + SD + GF
Sbjct: 461 ERG----YDTLTVGDAGKVGDTRSVLYVLTGSSVPDLIVSMSNQMWLHLQSDDSIGSPGF 516
Query: 138 MAMFSAAEPNERGDQYCGGLLDRPSGSF-------------------------KTPNWPD 172
A++ E GD R SF + W
Sbjct: 517 KAVYQEIEKGGCGDPGIPAYGKRTGSSFLHGDTLTFECPAAFELVGERVITCQQNNQWSG 576
Query: 173 R----------------------DYPA----GVTCVWHIVAPKNQLIELKFEKFDVERDN 206
+YP + CVW I++ I L F FDVE
Sbjct: 577 NKPSCVFSCFFNFTASSGIILSPNYPEEYGNNMNCVWLIISEPGSRIHLIFNDFDVEP-- 634
Query: 207 YCRYDYVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGF 261
++D++AV + G ++D +G + G+ P+ + S + + ++F SD S T GF
Sbjct: 635 --QFDFLAVKDDG-ISDITVLGTFSGNEVPSQLASSGHIVRLEFQSDHSTTGRGF 686
Score = 65.1 bits (157), Expect = 1e-10
Identities = 38/120 (31%), Positives = 59/120 (49%), Gaps = 5/120 (4%)
Query: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVD 92
CGG++ G +G I S GFP YP + CTW I E + L+F LE D +D +
Sbjct: 32 CGGLVQGPNGTIESPGFPHGYPNYANCTWIIITGERNRIQLSFHTFALEED----FDILS 87
Query: 93 VYNGH-ANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNERGD 151
VY+G G R G P ++VS+G+ + + +D + GF A++ + G+
Sbjct: 88 VYDGQPQQGNLKVRLSGFQLPSSIVSTGSILTLWFTTDFAVSAQGFKALYEVLPSHTCGN 147
Score = 62.0 bits (149), Expect = 1e-09
Identities = 36/118 (30%), Positives = 61/118 (51%), Gaps = 6/118 (5%)
Query: 152 QYCGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYD 211
Q CGGL+ P+G+ ++P +P YP C W I+ + I+L F F +E D +D
Sbjct: 30 QNCGGLVQGPNGTIESPGFP-HGYPNYANCTWIIITGERNRIQLSFHTFALEED----FD 84
Query: 212 YVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIGHYIFRP 269
++V++G ++ + G P+ IVS + L + F +D +++A GF Y P
Sbjct: 85 ILSVYDGQPQQGNLKV-RLSGFQLPSSIVSTGSILTLWFTTDFAVSAQGFKALYEVLP 141
Score = 59.7 bits (143), Expect = 5e-09
Identities = 41/121 (33%), Positives = 52/121 (42%), Gaps = 10/121 (8%)
Query: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVD 92
CGG L G S I S FP Y N+ CTW I G + L F LE YDF++
Sbjct: 208 CGGTLRGTSSSISSPHFPSEYENNADCTWTILAEPGDTIALVFTDFQLEEG----YDFLE 263
Query: 93 VYNGHANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMF---SAAEPNER 149
+ A + G P ++SS N + + SD+N GF A F A E R
Sbjct: 264 ISGTEAPSIWL---TGMNLPSPVISSKNWLRLHFTSDSNHRRKGFNAQFQVKKAIELKSR 320
Query: 150 G 150
G
Sbjct: 321 G 321
Score = 59.7 bits (143), Expect = 5e-09
Identities = 41/114 (35%), Positives = 60/114 (52%), Gaps = 7/114 (6%)
Query: 154 CGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPK-NQLIELKFEKFDVERDNYCRYDY 212
CG L PSG +PN+P + Y CVW I +++I+L FE+F++ER YD
Sbjct: 412 CGSNLRGPSGVITSPNYPVQ-YEDNAHCVWVITTTDPDKVIKLAFEEFELERG----YDT 466
Query: 213 VAVFNGGEVNDARRI-GKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIGHY 265
+ V + G+V D R + G S P IVS N++ + SD S+ + GF Y
Sbjct: 467 LTVGDAGKVGDTRSVLYVLTGSSVPDLIVSMSNQMWLHLQSDDSIGSPGFKAVY 520
Score = 59.3 bits (142), Expect = 6e-09
Identities = 37/113 (32%), Positives = 56/113 (49%), Gaps = 7/113 (6%)
Query: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVD 92
CGG + G+SG + S GFP YP + CTW I V GK V + F LES +D++
Sbjct: 931 CGGYIQGKSGTVLSPGFPDFYPNSLNCTWTIEVSHGKGVQMIFHTFHLESS----HDYLL 986
Query: 93 VYNGHANGQRIGRFCGTFRPGALVSS--GN-KMMVQMISDANTAGNGFMAMFS 142
+ + + + R G+ P + + GN ++ ISD + + GF FS
Sbjct: 987 ITEDGSFSEPVARLTGSVLPHTIKAGLFGNFTAQLRFISDFSISYEGFNITFS 1039
Score = 55.5 bits (132), Expect = 9e-08
Identities = 44/150 (29%), Positives = 68/150 (45%), Gaps = 17/150 (11%)
Query: 112 PGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNERGDQYCGGLLDRPSGSFKTPNWP 171
PG ++ G+ ++ ++S N A F A F AE CGG L S S +P++P
Sbjct: 173 PGYILE-GHAILTCIVSPGNGASWDFPAPFCRAEGA------CGGTLRGTSSSISSPHFP 225
Query: 172 DRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVAVFNGGEVNDARRIGKYC 231
+Y C W I+A I L F F +E YD++ + +G E G
Sbjct: 226 S-EYENNADCTWTILAEPGDTIALVFTDFQLEEG----YDFLEI-SGTEAPSIWLTGM-- 277
Query: 232 GDSPPAPIVSERNELLIQFLSDLSLTADGF 261
+ P+P++S +N L + F SD + GF
Sbjct: 278 --NLPSPVISSKNWLRLHFTSDSNHRRKGF 305
Score = 43.5 bits (101), Expect = 4e-04
Identities = 32/118 (27%), Positives = 53/118 (44%), Gaps = 7/118 (5%)
Query: 28 RPVFTCGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDL-ESDNLC 86
R V CG + G G + S FP Y N +C +KI GK + L R L E D L
Sbjct: 1100 RCVAECGASVKGNEGTLLSPNFPSNYDNNHECIYKIETEAGKGIHLRTRSFQLFEGDTLK 1159
Query: 87 RYDFVDVYNGHANGQRIGRFCGTFRPGALV-SSGNKMMVQMISDANTAGNGFMAMFSA 143
YD D ++ + +G F G ++ S+ N + ++ ++ + GF +++
Sbjct: 1160 VYDGKD-----SSSRPLGTFTKNELLGLILNSTSNHLWLEFNTNGSDTDQGFQLTYTS 1212
Score = 42.4 bits (98), Expect = 8e-04
Identities = 40/156 (25%), Positives = 73/156 (46%), Gaps = 16/156 (10%)
Query: 19 QLSRQQSPERPVFTCGG------ILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVV 72
+LS Q E + TC + TG SG I S G+PG Y + C+W I V +
Sbjct: 2302 KLSSQLQFEGSLPTCEAQCPANEVRTGSSGVILSPGYPGNYFNSQTCSWSIKVEPNYNIT 2361
Query: 73 LNFRFID-LESDNLCRYDFVDVYNGHANGQR---IGRFCGTFRPGALVSSGNKMMVQMIS 128
+ F+D +S+ ++D ++V++G ++GQ + S N++ ++ +
Sbjct: 2362 I---FVDTFQSEK--QFDALEVFDG-SSGQSPLLVVLSGNHTEQSNFTSRSNQLYLRWST 2415
Query: 129 DANTAGNGFMAMFSAAEPNERGDQYCGGLLDRPSGS 164
D T+ GF ++A + GG+L+R +G+
Sbjct: 2416 DHATSKKGFKIRYAAPYCSLTHPLKNGGILNRTAGA 2451
>gi|11415040 matriptase [Homo sapiens]
Length = 855
Score = 100 bits (249), Expect = 2e-21
Identities = 69/229 (30%), Positives = 105/229 (45%), Gaps = 25/229 (10%)
Query: 48 GFP-GVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVDVYN--GHANGQRIG 104
GFP YP +++C W + V+ L FR DL S + D V VYN +
Sbjct: 232 GFPDSPYPAHARCQWALRGDADSVLSLTFRSFDLASCDERGSDLVTVYNTLSPMEPHALV 291
Query: 105 RFCGTFRPG---ALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNERGDQYCGGLLDRP 161
+ CGT+ P SS N +++ +I++ GF A F CGG L +
Sbjct: 292 QLCGTYPPSYNLTFHSSQNVLLITLITNTERRHPGFEATFFQLPRMSS----CGGRLRKA 347
Query: 162 SGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNY----CRYDYVAVFN 217
G+F +P +P YP + C W+I P NQ ++++F+ F + C DYV +
Sbjct: 348 QGTFNSPYYPGH-YPPNIDCTWNIEVPNNQHVKVRFKFFYLLEPGVPAGTCPKDYVEI-- 404
Query: 218 GGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIGHYI 266
GE KYCG+ + S N++ ++F SD S T GF+ Y+
Sbjct: 405 NGE--------KYCGERSQFVVTSNSNKITVRFHSDQSYTDTGFLAEYL 445
Score = 66.6 bits (161), Expect = 4e-11
Identities = 38/121 (31%), Positives = 61/121 (50%), Gaps = 12/121 (9%)
Query: 32 TCGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNL----CR 87
+CGG L G S +PG YPPN CTW I VP + V + F+F L + C
Sbjct: 339 SCGGRLRKAQGTFNSPYYPGHYPPNIDCTWNIEVPNNQHVKVRFKFFYLLEPGVPAGTCP 398
Query: 88 YDFVDVYNGHANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPN 147
D+V++ NG+ ++CG + S+ NK+ V+ SD + GF+A + + + +
Sbjct: 399 KDYVEI-----NGE---KYCGERSQFVVTSNSNKITVRFHSDQSYTDTGFLAEYLSYDSS 450
Query: 148 E 148
+
Sbjct: 451 D 451
Score = 51.2 bits (121), Expect = 2e-06
Identities = 30/109 (27%), Positives = 48/109 (44%), Gaps = 3/109 (2%)
Query: 165 FKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVAVFNGGEVNDA 224
F TP +PD YPA C W + + ++ L F FD+ + D V V+N +
Sbjct: 228 FTTPGFPDSPYPAHARCQWALRGDADSVLSLTFRSFDLASCDERGSDLVTVYNTLSPMEP 287
Query: 225 RRIGKYCGDSPPA---PIVSERNELLIQFLSDLSLTADGFIGHYIFRPK 270
+ + CG PP+ S +N LLI +++ GF + P+
Sbjct: 288 HALVQLCGTYPPSYNLTFHSSQNVLLITLITNTERRHPGFEATFFQLPR 336
>gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sapiens]
Length = 3667
Score = 94.7 bits (234), Expect = 1e-19
Identities = 81/298 (27%), Positives = 120/298 (40%), Gaps = 67/298 (22%)
Query: 30 VFTCGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYD 89
+ CGGILT G I S G+P Y N C WKITVPEG + + E + +D
Sbjct: 1896 IVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHN----WD 1951
Query: 90 FVDVYN-GHANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGF------MAMFS 142
+D Y+ G N R+G + GT P L S+ N + + SD + + GF + + S
Sbjct: 1952 SLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDS 2011
Query: 143 AAEPN------ERGDQY------------------------------------------C 154
EP + GD+Y C
Sbjct: 2012 CPEPQTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLAQC 2071
Query: 155 GGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVA 214
GG + SG +P +P +YP+ + C W I P + L+F F E +DY+
Sbjct: 2072 GGAMSDFSGVILSPGFPG-NYPSSLDCTWTINLPIGFGVHLQFVNFSTE----TIHDYLE 2126
Query: 215 VFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIGHYIFRPKKL 272
V G + IG+ G P+ + S +E + F SD S GF H +++ +L
Sbjct: 2127 V-RSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGF--HIVYQAYQL 2181
Score = 83.2 bits (204), Expect = 4e-16
Identities = 76/284 (26%), Positives = 120/284 (42%), Gaps = 67/284 (23%)
Query: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVD 92
CGG ++ SG I S GFPG YP + CTW I +P G V L +F++ ++ + +D+++
Sbjct: 2071 CGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHL--QFVNFSTETI--HDYLE 2126
Query: 93 VYNGHANGQR-IGRFCGTFRPGALVS-------------SGNKM---------MVQMISD 129
V +G + IGR G P +L S S NK +Q D
Sbjct: 2127 VRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCPD 2186
Query: 130 ANTAGNGFMAM--FSAAE------------------------------PNERGDQYCGGL 157
NGF+ F+ + P R + CGG
Sbjct: 2187 PRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALCGGN 2246
Query: 158 LDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVAVFN 217
+ +G+ +P +PD +YP C W + P I + F E YD++ V++
Sbjct: 2247 ITAMNGTIYSPGYPD-EYPNFQDCFWLVRVPPGNGIYINFTVLQTEPI----YDFITVWD 2301
Query: 218 GGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGF 261
G + N + IG++ G++ + S N++LI+F SD T GF
Sbjct: 2302 GPDQNSPQ-IGQFSGNTALESVYSTSNQILIKFHSD--FTTSGF 2342
Score = 80.5 bits (197), Expect = 3e-15
Identities = 97/393 (24%), Positives = 145/393 (36%), Gaps = 91/393 (23%)
Query: 33 CGGILTGES-GFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFV 91
CGG GES G I S G+P Y N +C W I V G +V L F D E+ +D +
Sbjct: 1374 CGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEAS----HDIL 1429
Query: 92 DVYNG-HANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAA------ 144
V++G N + G+ P + S+ N + +Q +D + +GF FS++
Sbjct: 1430 RVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACR 1489
Query: 145 ------------EPNERGDQY-------------------------------------CG 155
+ E GD CG
Sbjct: 1490 DPGVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPCG 1549
Query: 156 GLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVAV 215
G L SG +PN+P YP C W I + +I L F F +E + YD++ +
Sbjct: 1550 GNLTGSSGFILSPNFP-HPYPHSRDCDWTITVNADYVISLAFISFSIEPN----YDFLYI 1604
Query: 216 FNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIGHYIFRPKKLPTT 275
++G + N + IG + P I S N + + F SD S++ GF Y KL +
Sbjct: 1605 YDGPDSN-SPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEY---KAKLRES 1660
Query: 276 TEQPVTTTFPVTTGLKPTVALCQQKCRRTGTLEGNYCSSDFVLAG-TVITTITRDG---- 330
P G+ + G+ YC + +VL G + +T I D
Sbjct: 1661 CFDPGNIMNGTRLGMD----------YKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPG 1710
Query: 331 ------SLHATVSIINIYKEGNLAIQQAGKNMS 357
S HA + EG + KN S
Sbjct: 1711 WNRALPSCHAPCGSRSTGSEGTVLSPNYPKNYS 1743
Score = 76.6 bits (187), Expect = 4e-14
Identities = 79/329 (24%), Positives = 124/329 (37%), Gaps = 72/329 (21%)
Query: 19 QLSRQQSPERPVFTCGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFI 78
QL RQ + ++TCGG L G +G I S GFP YP + CTW I E + + F+
Sbjct: 12 QLDRQTASGF-IYTCGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSF 70
Query: 79 DLESDNLCRYDFVDVYNGHANGQRI-GRFCGTFRPGALVSSGNKMMVQMISDANTAGNGF 137
LE + YD++ +Y+GH + R G P + S+ + +++ SD + +GF
Sbjct: 71 ALEEE----YDYLSLYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGF 126
Query: 138 MAMFSAAEPNERGDQ-----------------------YCGGLLDRP------SGSFKTP 168
+ + + G+ G +LD + S T
Sbjct: 127 KVYYEELQSSSCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTA 186
Query: 169 NWP----------------------------DRDYPAGVTCVWHIVAPKNQLIELKFEKF 200
+W +Y C W IVA I L F F
Sbjct: 187 SWDFPVPICRAEDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDF 246
Query: 201 DVERDNYCRYDYVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADG 260
+E +YDY+ + E ++ I G + P PI+S +N L + F++D + G
Sbjct: 247 QMEE----KYDYLEI----EGSEPPTIW-LSGMNIPPPIISNKNWLRLHFVTDSNHRYRG 297
Query: 261 FIGHYIFRPKKLPTTTEQPVTTTFPVTTG 289
F Y TT+ + TTG
Sbjct: 298 FSAPYQGSSTLTHTTSTGELEEHNRTTTG 326
Score = 75.5 bits (184), Expect = 8e-14
Identities = 84/314 (26%), Positives = 122/314 (38%), Gaps = 73/314 (23%)
Query: 23 QQSPERPVFTCGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLES 82
Q SP + CGG LTG SGFI S FP YP + C W ITV V+ L F +E
Sbjct: 1538 QPSPPVCIAPCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEP 1597
Query: 83 DNLCRYDFVDVYNG-HANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMF 141
+ YDF+ +Y+G +N IG F + P + SS N M + SD + + GF +
Sbjct: 1598 N----YDFLYIYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEY 1653
Query: 142 SAAEPNERGD---------------------QYC--GGLLDRPS------GSFKTPNW-- 170
A D YC G +L S G P W
Sbjct: 1654 KAKLRESCFDPGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNR 1713
Query: 171 --PDRDYPAGV----------------------TCVWHIVAPKNQLIELKFEKFDVERDN 206
P P G CV+ I PK ++ +F F
Sbjct: 1714 ALPSCHAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTS--- 1770
Query: 207 YCRYDYVAVFNGGEVND---ARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIG 263
+D V V++G + G + G+S P +S N++ I+F S +TA GF
Sbjct: 1771 --LHDVVEVYDGPTQQSSLLSSLSGSHSGESLP---LSSGNQITIRFTSVGPITAKGF-- 1823
Query: 264 HYIFRPKKLPTTTE 277
H++++ ++T+
Sbjct: 1824 HFVYQAVPRTSSTQ 1837
Score = 75.1 bits (183), Expect = 1e-13
Identities = 72/293 (24%), Positives = 110/293 (37%), Gaps = 67/293 (22%)
Query: 30 VFTCGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYD 89
+F C T G + S +P Y N C W I G + L+F DLES ++D
Sbjct: 678 IFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLES----QFD 733
Query: 90 FVDVYNGHA-NGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNE 148
F+ V +G + +G F G P L S+ + + ++ +D + +G GF ++ NE
Sbjct: 734 FLAVKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTFGHNE 793
Query: 149 ------------RGDQY----------------------------------------CG- 155
GD + CG
Sbjct: 794 CPDPGIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKCGA 853
Query: 156 ---GLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDY 212
G PSG +P WP Y + C W I A I++ FE+F E YD
Sbjct: 854 PCGGHFSAPSGVILSPGWPGY-YKDSLNCEWVIEAEPGHSIKITFERFQTE----LNYDV 908
Query: 213 VAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIGHY 265
+ V +G + + +G Y G P + S N + + F +D S + +GF HY
Sbjct: 909 LEVHDGPNLL-SPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHY 960
Score = 66.2 bits (160), Expect = 5e-11
Identities = 72/295 (24%), Positives = 115/295 (38%), Gaps = 67/295 (22%)
Query: 25 SPERPVF---TCGGILTGESGFIGSEGFPGVYPPNSKCTWKIT-VPEGKVVVLNFRFIDL 80
S RPV TCG L G SG S FP Y N++C W IT V KV+ +NF DL
Sbjct: 497 SDHRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDL 556
Query: 81 ESDNLCRYDFVDVYNGHANGQR---IGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGF 137
E YD + + +G G + G+F P +VS ++M + + +D + GF
Sbjct: 557 E----IGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGF 612
Query: 138 MAMFSAAEPNERGD------------------------QYCGGLLDRPSGSFKTPNWPDR 173
+ E GD Q+ L+ S + N
Sbjct: 613 KVNYKEIEKESCGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSA 672
Query: 174 DYPAGV-TCVWHIVAPKNQL--------------------------IELKFEKFDVERDN 206
+ P + C+ + AP + I L F FD+E
Sbjct: 673 NIPICIFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLE--- 729
Query: 207 YCRYDYVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGF 261
++D++AV G+ ++ +G + G P+ + S + L ++F +D S++ GF
Sbjct: 730 -SQFDFLAV-KDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGF 782
Score = 66.2 bits (160), Expect = 5e-11
Identities = 67/288 (23%), Positives = 104/288 (36%), Gaps = 71/288 (24%)
Query: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVD 92
CGG + SG I S G+PG Y + C W I G + + F E + YD ++
Sbjct: 855 CGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELN----YDVLE 910
Query: 93 VYNG-HANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGN---------------- 135
V++G + +G + GT P L SS N + + +D + + N
Sbjct: 911 VHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYSC 970
Query: 136 ------------------GFMAMFSA--------------------AEPNERGDQYCGGL 157
G FS + P D CGG
Sbjct: 971 LDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCGGD 1030
Query: 158 LDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVAVFN 217
+ PSG+ +P +P+ YP + C W + + ++ F F +E +DY+ +
Sbjct: 1031 VRGPSGTILSPGYPE-FYPNSLNCTWTVDVTHGKGVQFNFHTFHLED----HHDYLLITE 1085
Query: 218 GGEVND--ARRIGKYCGDSPPAPIVSERNELLIQ--FLSDLSLTADGF 261
G AR G D PP Q F+SD S++ +GF
Sbjct: 1086 NGSFTQPLARLTG---SDLPPTINAGLYGNFRAQLRFISDFSISYEGF 1130
Score = 65.5 bits (158), Expect = 9e-11
Identities = 41/114 (35%), Positives = 65/114 (57%), Gaps = 7/114 (6%)
Query: 154 CGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPK-NQLIELKFEKFDVERDNYCRYDY 212
CG L PSG+F +PN+P + Y + CVW I A N++I++ FE+FD+E YD
Sbjct: 508 CGSNLQGPSGTFTSPNFPFQ-YDSNAQCVWVITAVNTNKVIQINFEEFDLE----IGYDT 562
Query: 213 VAVFNGGEVNDARRIGK-YCGDSPPAPIVSERNELLIQFLSDLSLTADGFIGHY 265
+ + +GGEV D R + + G P IVS +++ + +D S+ + GF +Y
Sbjct: 563 LTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNY 616
Score = 57.4 bits (137), Expect = 2e-08
Identities = 37/113 (32%), Positives = 55/113 (48%), Gaps = 7/113 (6%)
Query: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVD 92
CGG + G SG I S G+P YP + CTW + V GK V NF LE +D++
Sbjct: 1027 CGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLED----HHDYLL 1082
Query: 93 VYNGHANGQRIGRFCGTFRPGALVSS--GN-KMMVQMISDANTAGNGFMAMFS 142
+ + Q + R G+ P + + GN + ++ ISD + + GF FS
Sbjct: 1083 ITENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFS 1135
Score = 40.4 bits (93), Expect = 0.003
Identities = 27/108 (25%), Positives = 47/108 (43%), Gaps = 12/108 (11%)
Query: 41 SGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVDVYNGHANG 100
+G I S G+P YP C W I+V +G + + F E + +D + VY+G
Sbjct: 2426 TGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKE----FDVLQVYDGPNIQ 2481
Query: 101 QRI-----GRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSA 143
+ G + F + S+G+++ +Q +D GF + A
Sbjct: 2482 SPVLISLSGDYSSAFN---ITSNGHEVFLQWSADHGNNKKGFRIRYIA 2526
Score = 37.4 bits (85), Expect = 0.025
Identities = 28/105 (26%), Positives = 44/105 (41%), Gaps = 5/105 (4%)
Query: 162 SGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVAVFNGGEV 221
+G +P +PD YP C W I K I + E F E++ +D + V++G +
Sbjct: 2426 TGVILSPGYPD-SYPNLQMCAWSISVEKGYNITMFVEFFQTEKE----FDVLQVYDGPNI 2480
Query: 222 NDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIGHYI 266
I S I S +E+ +Q+ +D GF YI
Sbjct: 2481 QSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYI 2525
>gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo
sapiens]
Length = 3538
Score = 94.7 bits (234), Expect = 1e-19
Identities = 81/298 (27%), Positives = 120/298 (40%), Gaps = 67/298 (22%)
Query: 30 VFTCGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYD 89
+ CGGILT G I S G+P Y N C WKITVPEG + + E + +D
Sbjct: 1832 IVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHN----WD 1887
Query: 90 FVDVYN-GHANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGF------MAMFS 142
+D Y+ G N R+G + GT P L S+ N + + SD + + GF + + S
Sbjct: 1888 SLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDS 1947
Query: 143 AAEPN------ERGDQY------------------------------------------C 154
EP + GD+Y C
Sbjct: 1948 CPEPQTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLAQC 2007
Query: 155 GGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVA 214
GG + SG +P +P +YP+ + C W I P + L+F F E +DY+
Sbjct: 2008 GGAMSDFSGVILSPGFPG-NYPSSLDCTWTINLPIGFGVHLQFVNFSTE----TIHDYLE 2062
Query: 215 VFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIGHYIFRPKKL 272
V G + IG+ G P+ + S +E + F SD S GF H +++ +L
Sbjct: 2063 V-RSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGF--HIVYQAYQL 2117
Score = 83.2 bits (204), Expect = 4e-16
Identities = 76/284 (26%), Positives = 120/284 (42%), Gaps = 67/284 (23%)
Query: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVD 92
CGG ++ SG I S GFPG YP + CTW I +P G V L +F++ ++ + +D+++
Sbjct: 2007 CGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHL--QFVNFSTETI--HDYLE 2062
Query: 93 VYNGHANGQR-IGRFCGTFRPGALVS-------------SGNKM---------MVQMISD 129
V +G + IGR G P +L S S NK +Q D
Sbjct: 2063 VRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCPD 2122
Query: 130 ANTAGNGFMAM--FSAAE------------------------------PNERGDQYCGGL 157
NGF+ F+ + P R + CGG
Sbjct: 2123 PRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALCGGN 2182
Query: 158 LDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVAVFN 217
+ +G+ +P +PD +YP C W + P I + F E YD++ V++
Sbjct: 2183 ITAMNGTIYSPGYPD-EYPNFQDCFWLVRVPPGNGIYINFTVLQTEPI----YDFITVWD 2237
Query: 218 GGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGF 261
G + N + IG++ G++ + S N++LI+F SD T GF
Sbjct: 2238 GPDQNSPQ-IGQFSGNTALESVYSTSNQILIKFHSD--FTTSGF 2278
Score = 80.5 bits (197), Expect = 3e-15
Identities = 97/393 (24%), Positives = 145/393 (36%), Gaps = 91/393 (23%)
Query: 33 CGGILTGES-GFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFV 91
CGG GES G I S G+P Y N +C W I V G +V L F D E+ +D +
Sbjct: 1310 CGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEAS----HDIL 1365
Query: 92 DVYNG-HANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAA------ 144
V++G N + G+ P + S+ N + +Q +D + +GF FS++
Sbjct: 1366 RVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACR 1425
Query: 145 ------------EPNERGDQY-------------------------------------CG 155
+ E GD CG
Sbjct: 1426 DPGVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPCG 1485
Query: 156 GLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVAV 215
G L SG +PN+P YP C W I + +I L F F +E + YD++ +
Sbjct: 1486 GNLTGSSGFILSPNFP-HPYPHSRDCDWTITVNADYVISLAFISFSIEPN----YDFLYI 1540
Query: 216 FNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIGHYIFRPKKLPTT 275
++G + N + IG + P I S N + + F SD S++ GF Y KL +
Sbjct: 1541 YDGPDSN-SPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEY---KAKLRES 1596
Query: 276 TEQPVTTTFPVTTGLKPTVALCQQKCRRTGTLEGNYCSSDFVLAG-TVITTITRDG---- 330
P G+ + G+ YC + +VL G + +T I D
Sbjct: 1597 CFDPGNIMNGTRLGMD----------YKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPG 1646
Query: 331 ------SLHATVSIINIYKEGNLAIQQAGKNMS 357
S HA + EG + KN S
Sbjct: 1647 WNRALPSCHAPCGSRSTGSEGTVLSPNYPKNYS 1679
Score = 77.8 bits (190), Expect = 2e-14
Identities = 87/375 (23%), Positives = 136/375 (36%), Gaps = 82/375 (21%)
Query: 30 VFTCGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYD 89
++TCGG L G +G I S GFP YP + CTW I E + + F+ LE + YD
Sbjct: 62 IYTCGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEE----YD 117
Query: 90 FVDVYNGHANGQRI-GRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNE 148
++ +Y+GH + R G P + S+ + +++ SD + +GF + + +
Sbjct: 118 YLSLYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSS 177
Query: 149 RGDQ-----------------------YCGGLLDRP------SGSFKTPNWP-------- 171
G+ G +LD + S T +W
Sbjct: 178 CGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRA 237
Query: 172 --------------------DRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYD 211
+Y C W IVA I L F F +E +YD
Sbjct: 238 EDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEE----KYD 293
Query: 212 YVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIGHY------ 265
Y+ + E ++ I G + P PI+S +N L + F++D + GF Y
Sbjct: 294 YLEI----EGSEPPTIW-LSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQVKKAI 348
Query: 266 IFRPKKLPTTTEQPVTTTFPVTT--GLKPTVALCQQKCRRTGTLEGNYCSSDFVLAGTVI 323
F+ + + + F + G+K LC G SDF L TV
Sbjct: 349 DFKSRGFKLFPGKDNSNKFSILNEGGIKTASNLCPDPGEPE---NGKRIGSDFSLGSTVQ 405
Query: 324 TTITRDGSLHATVSI 338
+ D L SI
Sbjct: 406 FSCDEDYVLQGAKSI 420
Score = 75.5 bits (184), Expect = 8e-14
Identities = 84/314 (26%), Positives = 122/314 (38%), Gaps = 73/314 (23%)
Query: 23 QQSPERPVFTCGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLES 82
Q SP + CGG LTG SGFI S FP YP + C W ITV V+ L F +E
Sbjct: 1474 QPSPPVCIAPCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEP 1533
Query: 83 DNLCRYDFVDVYNG-HANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMF 141
+ YDF+ +Y+G +N IG F + P + SS N M + SD + + GF +
Sbjct: 1534 N----YDFLYIYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEY 1589
Query: 142 SAAEPNERGD---------------------QYC--GGLLDRPS------GSFKTPNW-- 170
A D YC G +L S G P W
Sbjct: 1590 KAKLRESCFDPGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNR 1649
Query: 171 --PDRDYPAGV----------------------TCVWHIVAPKNQLIELKFEKFDVERDN 206
P P G CV+ I PK ++ +F F
Sbjct: 1650 ALPSCHAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTS--- 1706
Query: 207 YCRYDYVAVFNGGEVND---ARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIG 263
+D V V++G + G + G+S P +S N++ I+F S +TA GF
Sbjct: 1707 --LHDVVEVYDGPTQQSSLLSSLSGSHSGESLP---LSSGNQITIRFTSVGPITAKGF-- 1759
Query: 264 HYIFRPKKLPTTTE 277
H++++ ++T+
Sbjct: 1760 HFVYQAVPRTSSTQ 1773
Score = 75.1 bits (183), Expect = 1e-13
Identities = 72/293 (24%), Positives = 110/293 (37%), Gaps = 67/293 (22%)
Query: 30 VFTCGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYD 89
+F C T G + S +P Y N C W I G + L+F DLES ++D
Sbjct: 614 IFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLES----QFD 669
Query: 90 FVDVYNGHA-NGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNE 148
F+ V +G + +G F G P L S+ + + ++ +D + +G GF ++ NE
Sbjct: 670 FLAVKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTFGHNE 729
Query: 149 ------------RGDQY----------------------------------------CG- 155
GD + CG
Sbjct: 730 CPDPGIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKCGA 789
Query: 156 ---GLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDY 212
G PSG +P WP Y + C W I A I++ FE+F E YD
Sbjct: 790 PCGGHFSAPSGVILSPGWPGY-YKDSLNCEWVIEAEPGHSIKITFERFQTE----LNYDV 844
Query: 213 VAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIGHY 265
+ V +G + + +G Y G P + S N + + F +D S + +GF HY
Sbjct: 845 LEVHDGPNLL-SPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHY 896
Score = 66.2 bits (160), Expect = 5e-11
Identities = 72/295 (24%), Positives = 115/295 (38%), Gaps = 67/295 (22%)
Query: 25 SPERPVF---TCGGILTGESGFIGSEGFPGVYPPNSKCTWKIT-VPEGKVVVLNFRFIDL 80
S RPV TCG L G SG S FP Y N++C W IT V KV+ +NF DL
Sbjct: 433 SDHRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDL 492
Query: 81 ESDNLCRYDFVDVYNGHANGQR---IGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGF 137
E YD + + +G G + G+F P +VS ++M + + +D + GF
Sbjct: 493 E----IGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGF 548
Query: 138 MAMFSAAEPNERGD------------------------QYCGGLLDRPSGSFKTPNWPDR 173
+ E GD Q+ L+ S + N
Sbjct: 549 KVNYKEIEKESCGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSA 608
Query: 174 DYPAGV-TCVWHIVAPKNQL--------------------------IELKFEKFDVERDN 206
+ P + C+ + AP + I L F FD+E
Sbjct: 609 NIPICIFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLE--- 665
Query: 207 YCRYDYVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGF 261
++D++AV G+ ++ +G + G P+ + S + L ++F +D S++ GF
Sbjct: 666 -SQFDFLAV-KDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGF 718
Score = 66.2 bits (160), Expect = 5e-11
Identities = 67/288 (23%), Positives = 104/288 (36%), Gaps = 71/288 (24%)
Query: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVD 92
CGG + SG I S G+PG Y + C W I G + + F E + YD ++
Sbjct: 791 CGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELN----YDVLE 846
Query: 93 VYNG-HANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGN---------------- 135
V++G + +G + GT P L SS N + + +D + + N
Sbjct: 847 VHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYSC 906
Query: 136 ------------------GFMAMFSA--------------------AEPNERGDQYCGGL 157
G FS + P D CGG
Sbjct: 907 LDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCGGD 966
Query: 158 LDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVAVFN 217
+ PSG+ +P +P+ YP + C W + + ++ F F +E +DY+ +
Sbjct: 967 VRGPSGTILSPGYPE-FYPNSLNCTWTVDVTHGKGVQFNFHTFHLED----HHDYLLITE 1021
Query: 218 GGEVND--ARRIGKYCGDSPPAPIVSERNELLIQ--FLSDLSLTADGF 261
G AR G D PP Q F+SD S++ +GF
Sbjct: 1022 NGSFTQPLARLTG---SDLPPTINAGLYGNFRAQLRFISDFSISYEGF 1066
Score = 65.5 bits (158), Expect = 9e-11
Identities = 41/114 (35%), Positives = 65/114 (57%), Gaps = 7/114 (6%)
Query: 154 CGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPK-NQLIELKFEKFDVERDNYCRYDY 212
CG L PSG+F +PN+P + Y + CVW I A N++I++ FE+FD+E YD
Sbjct: 444 CGSNLQGPSGTFTSPNFPFQ-YDSNAQCVWVITAVNTNKVIQINFEEFDLE----IGYDT 498
Query: 213 VAVFNGGEVNDARRIGK-YCGDSPPAPIVSERNELLIQFLSDLSLTADGFIGHY 265
+ + +GGEV D R + + G P IVS +++ + +D S+ + GF +Y
Sbjct: 499 LTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNY 552
Score = 57.4 bits (137), Expect = 2e-08
Identities = 37/113 (32%), Positives = 55/113 (48%), Gaps = 7/113 (6%)
Query: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVD 92
CGG + G SG I S G+P YP + CTW + V GK V NF LE +D++
Sbjct: 963 CGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLED----HHDYLL 1018
Query: 93 VYNGHANGQRIGRFCGTFRPGALVSS--GN-KMMVQMISDANTAGNGFMAMFS 142
+ + Q + R G+ P + + GN + ++ ISD + + GF FS
Sbjct: 1019 ITENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFS 1071
Score = 40.4 bits (93), Expect = 0.003
Identities = 27/108 (25%), Positives = 47/108 (43%), Gaps = 12/108 (11%)
Query: 41 SGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVDVYNGHANG 100
+G I S G+P YP C W I+V +G + + F E + +D + VY+G
Sbjct: 2362 TGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKE----FDVLQVYDGPNIQ 2417
Query: 101 QRI-----GRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSA 143
+ G + F + S+G+++ +Q +D GF + A
Sbjct: 2418 SPVLISLSGDYSSAFN---ITSNGHEVFLQWSADHGNNKKGFRIRYIA 2462
Score = 37.4 bits (85), Expect = 0.025
Identities = 28/105 (26%), Positives = 44/105 (41%), Gaps = 5/105 (4%)
Query: 162 SGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVAVFNGGEV 221
+G +P +PD YP C W I K I + E F E++ +D + V++G +
Sbjct: 2362 TGVILSPGYPD-SYPNLQMCAWSISVEKGYNITMFVEFFQTEKE----FDVLQVYDGPNI 2416
Query: 222 NDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIGHYI 266
I S I S +E+ +Q+ +D GF YI
Sbjct: 2417 QSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYI 2461
>gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sapiens]
Length = 3707
Score = 94.7 bits (234), Expect = 1e-19
Identities = 81/298 (27%), Positives = 120/298 (40%), Gaps = 67/298 (22%)
Query: 30 VFTCGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYD 89
+ CGGILT G I S G+P Y N C WKITVPEG + + E + +D
Sbjct: 1936 IVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHN----WD 1991
Query: 90 FVDVYN-GHANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGF------MAMFS 142
+D Y+ G N R+G + GT P L S+ N + + SD + + GF + + S
Sbjct: 1992 SLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDS 2051
Query: 143 AAEPN------ERGDQY------------------------------------------C 154
EP + GD+Y C
Sbjct: 2052 CPEPQTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLAQC 2111
Query: 155 GGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVA 214
GG + SG +P +P +YP+ + C W I P + L+F F E +DY+
Sbjct: 2112 GGAMSDFSGVILSPGFPG-NYPSSLDCTWTINLPIGFGVHLQFVNFSTE----TIHDYLE 2166
Query: 215 VFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIGHYIFRPKKL 272
V G + IG+ G P+ + S +E + F SD S GF H +++ +L
Sbjct: 2167 V-RSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGF--HIVYQAYQL 2221
Score = 83.2 bits (204), Expect = 4e-16
Identities = 76/284 (26%), Positives = 120/284 (42%), Gaps = 67/284 (23%)
Query: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVD 92
CGG ++ SG I S GFPG YP + CTW I +P G V L +F++ ++ + +D+++
Sbjct: 2111 CGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHL--QFVNFSTETI--HDYLE 2166
Query: 93 VYNGHANGQR-IGRFCGTFRPGALVS-------------SGNKM---------MVQMISD 129
V +G + IGR G P +L S S NK +Q D
Sbjct: 2167 VRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCPD 2226
Query: 130 ANTAGNGFMAM--FSAAE------------------------------PNERGDQYCGGL 157
NGF+ F+ + P R + CGG
Sbjct: 2227 PRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALCGGN 2286
Query: 158 LDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVAVFN 217
+ +G+ +P +PD +YP C W + P I + F E YD++ V++
Sbjct: 2287 ITAMNGTIYSPGYPD-EYPNFQDCFWLVRVPPGNGIYINFTVLQTEPI----YDFITVWD 2341
Query: 218 GGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGF 261
G + N + IG++ G++ + S N++LI+F SD T GF
Sbjct: 2342 GPDQNSPQ-IGQFSGNTALESVYSTSNQILIKFHSD--FTTSGF 2382
Score = 80.5 bits (197), Expect = 3e-15
Identities = 97/393 (24%), Positives = 145/393 (36%), Gaps = 91/393 (23%)
Query: 33 CGGILTGES-GFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFV 91
CGG GES G I S G+P Y N +C W I V G +V L F D E+ +D +
Sbjct: 1414 CGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEAS----HDIL 1469
Query: 92 DVYNG-HANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAA------ 144
V++G N + G+ P + S+ N + +Q +D + +GF FS++
Sbjct: 1470 RVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACR 1529
Query: 145 ------------EPNERGDQY-------------------------------------CG 155
+ E GD CG
Sbjct: 1530 DPGVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPCG 1589
Query: 156 GLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVAV 215
G L SG +PN+P YP C W I + +I L F F +E + YD++ +
Sbjct: 1590 GNLTGSSGFILSPNFP-HPYPHSRDCDWTITVNADYVISLAFISFSIEPN----YDFLYI 1644
Query: 216 FNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIGHYIFRPKKLPTT 275
++G + N + IG + P I S N + + F SD S++ GF Y KL +
Sbjct: 1645 YDGPDSN-SPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEY---KAKLRES 1700
Query: 276 TEQPVTTTFPVTTGLKPTVALCQQKCRRTGTLEGNYCSSDFVLAG-TVITTITRDG---- 330
P G+ + G+ YC + +VL G + +T I D
Sbjct: 1701 CFDPGNIMNGTRLGMD----------YKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPG 1750
Query: 331 ------SLHATVSIINIYKEGNLAIQQAGKNMS 357
S HA + EG + KN S
Sbjct: 1751 WNRALPSCHAPCGSRSTGSEGTVLSPNYPKNYS 1783
Score = 76.3 bits (186), Expect = 5e-14
Identities = 75/318 (23%), Positives = 119/318 (37%), Gaps = 71/318 (22%)
Query: 30 VFTCGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYD 89
++TCGG L G +G I S GFP YP + CTW I E + + F+ LE + YD
Sbjct: 62 IYTCGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEE----YD 117
Query: 90 FVDVYNGHANGQRI-GRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNE 148
++ +Y+GH + R G P + S+ + +++ SD + +GF + + +
Sbjct: 118 YLSLYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSS 177
Query: 149 RGDQ-----------------------YCGGLLDRP------SGSFKTPNWP-------- 171
G+ G +LD + S T +W
Sbjct: 178 CGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRA 237
Query: 172 --------------------DRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYD 211
+Y C W IVA I L F F +E +YD
Sbjct: 238 EDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEE----KYD 293
Query: 212 YVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIGHYIFRPKK 271
Y+ + E ++ I G + P PI+S +N L + F++D + GF Y
Sbjct: 294 YLEI----EGSEPPTIW-LSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQGSSTL 348
Query: 272 LPTTTEQPVTTTFPVTTG 289
TT+ + TTG
Sbjct: 349 THTTSTGELEEHNRTTTG 366
Score = 75.5 bits (184), Expect = 8e-14
Identities = 84/314 (26%), Positives = 122/314 (38%), Gaps = 73/314 (23%)
Query: 23 QQSPERPVFTCGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLES 82
Q SP + CGG LTG SGFI S FP YP + C W ITV V+ L F +E
Sbjct: 1578 QPSPPVCIAPCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEP 1637
Query: 83 DNLCRYDFVDVYNG-HANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMF 141
+ YDF+ +Y+G +N IG F + P + SS N M + SD + + GF +
Sbjct: 1638 N----YDFLYIYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEY 1693
Query: 142 SAAEPNERGD---------------------QYC--GGLLDRPS------GSFKTPNW-- 170
A D YC G +L S G P W
Sbjct: 1694 KAKLRESCFDPGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNR 1753
Query: 171 --PDRDYPAGV----------------------TCVWHIVAPKNQLIELKFEKFDVERDN 206
P P G CV+ I PK ++ +F F
Sbjct: 1754 ALPSCHAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTS--- 1810
Query: 207 YCRYDYVAVFNGGEVND---ARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIG 263
+D V V++G + G + G+S P +S N++ I+F S +TA GF
Sbjct: 1811 --LHDVVEVYDGPTQQSSLLSSLSGSHSGESLP---LSSGNQITIRFTSVGPITAKGF-- 1863
Query: 264 HYIFRPKKLPTTTE 277
H++++ ++T+
Sbjct: 1864 HFVYQAVPRTSSTQ 1877
Score = 75.1 bits (183), Expect = 1e-13
Identities = 72/293 (24%), Positives = 110/293 (37%), Gaps = 67/293 (22%)
Query: 30 VFTCGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYD 89
+F C T G + S +P Y N C W I G + L+F DLES ++D
Sbjct: 718 IFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLES----QFD 773
Query: 90 FVDVYNGHA-NGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNE 148
F+ V +G + +G F G P L S+ + + ++ +D + +G GF ++ NE
Sbjct: 774 FLAVKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTFGHNE 833
Query: 149 ------------RGDQY----------------------------------------CG- 155
GD + CG
Sbjct: 834 CPDPGIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKCGA 893
Query: 156 ---GLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDY 212
G PSG +P WP Y + C W I A I++ FE+F E YD
Sbjct: 894 PCGGHFSAPSGVILSPGWPGY-YKDSLNCEWVIEAEPGHSIKITFERFQTE----LNYDV 948
Query: 213 VAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIGHY 265
+ V +G + + +G Y G P + S N + + F +D S + +GF HY
Sbjct: 949 LEVHDGPNLL-SPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHY 1000
Score = 66.2 bits (160), Expect = 5e-11
Identities = 72/295 (24%), Positives = 115/295 (38%), Gaps = 67/295 (22%)
Query: 25 SPERPVF---TCGGILTGESGFIGSEGFPGVYPPNSKCTWKIT-VPEGKVVVLNFRFIDL 80
S RPV TCG L G SG S FP Y N++C W IT V KV+ +NF DL
Sbjct: 537 SDHRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDL 596
Query: 81 ESDNLCRYDFVDVYNGHANGQR---IGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGF 137
E YD + + +G G + G+F P +VS ++M + + +D + GF
Sbjct: 597 E----IGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGF 652
Query: 138 MAMFSAAEPNERGD------------------------QYCGGLLDRPSGSFKTPNWPDR 173
+ E GD Q+ L+ S + N
Sbjct: 653 KVNYKEIEKESCGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSA 712
Query: 174 DYPAGV-TCVWHIVAPKNQL--------------------------IELKFEKFDVERDN 206
+ P + C+ + AP + I L F FD+E
Sbjct: 713 NIPICIFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLE--- 769
Query: 207 YCRYDYVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGF 261
++D++AV G+ ++ +G + G P+ + S + L ++F +D S++ GF
Sbjct: 770 -SQFDFLAV-KDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGF 822
Score = 66.2 bits (160), Expect = 5e-11
Identities = 67/288 (23%), Positives = 104/288 (36%), Gaps = 71/288 (24%)
Query: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVD 92
CGG + SG I S G+PG Y + C W I G + + F E + YD ++
Sbjct: 895 CGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELN----YDVLE 950
Query: 93 VYNG-HANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGN---------------- 135
V++G + +G + GT P L SS N + + +D + + N
Sbjct: 951 VHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYSC 1010
Query: 136 ------------------GFMAMFSA--------------------AEPNERGDQYCGGL 157
G FS + P D CGG
Sbjct: 1011 LDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCGGD 1070
Query: 158 LDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVAVFN 217
+ PSG+ +P +P+ YP + C W + + ++ F F +E +DY+ +
Sbjct: 1071 VRGPSGTILSPGYPE-FYPNSLNCTWTVDVTHGKGVQFNFHTFHLED----HHDYLLITE 1125
Query: 218 GGEVND--ARRIGKYCGDSPPAPIVSERNELLIQ--FLSDLSLTADGF 261
G AR G D PP Q F+SD S++ +GF
Sbjct: 1126 NGSFTQPLARLTG---SDLPPTINAGLYGNFRAQLRFISDFSISYEGF 1170
Score = 65.5 bits (158), Expect = 9e-11
Identities = 41/114 (35%), Positives = 65/114 (57%), Gaps = 7/114 (6%)
Query: 154 CGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPK-NQLIELKFEKFDVERDNYCRYDY 212
CG L PSG+F +PN+P + Y + CVW I A N++I++ FE+FD+E YD
Sbjct: 548 CGSNLQGPSGTFTSPNFPFQ-YDSNAQCVWVITAVNTNKVIQINFEEFDLE----IGYDT 602
Query: 213 VAVFNGGEVNDARRIGK-YCGDSPPAPIVSERNELLIQFLSDLSLTADGFIGHY 265
+ + +GGEV D R + + G P IVS +++ + +D S+ + GF +Y
Sbjct: 603 LTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNY 656
Score = 57.4 bits (137), Expect = 2e-08
Identities = 37/113 (32%), Positives = 55/113 (48%), Gaps = 7/113 (6%)
Query: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVD 92
CGG + G SG I S G+P YP + CTW + V GK V NF LE +D++
Sbjct: 1067 CGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLED----HHDYLL 1122
Query: 93 VYNGHANGQRIGRFCGTFRPGALVSS--GN-KMMVQMISDANTAGNGFMAMFS 142
+ + Q + R G+ P + + GN + ++ ISD + + GF FS
Sbjct: 1123 ITENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFS 1175
Score = 40.4 bits (93), Expect = 0.003
Identities = 27/108 (25%), Positives = 47/108 (43%), Gaps = 12/108 (11%)
Query: 41 SGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVDVYNGHANG 100
+G I S G+P YP C W I+V +G + + F E + +D + VY+G
Sbjct: 2466 TGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKE----FDVLQVYDGPNIQ 2521
Query: 101 QRI-----GRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSA 143
+ G + F + S+G+++ +Q +D GF + A
Sbjct: 2522 SPVLISLSGDYSSAFN---ITSNGHEVFLQWSADHGNNKKGFRIRYIA 2566
Score = 37.4 bits (85), Expect = 0.025
Identities = 28/105 (26%), Positives = 44/105 (41%), Gaps = 5/105 (4%)
Query: 162 SGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVAVFNGGEV 221
+G +P +PD YP C W I K I + E F E++ +D + V++G +
Sbjct: 2466 TGVILSPGYPD-SYPNLQMCAWSISVEKGYNITMFVEFFQTEKE----FDVLQVYDGPNI 2520
Query: 222 NDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIGHYI 266
I S I S +E+ +Q+ +D GF YI
Sbjct: 2521 QSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYI 2565
>gi|73623026 mannan-binding lectin serine protease 1 isoform 3 [Homo
sapiens]
Length = 380
Score = 92.4 bits (228), Expect = 7e-19
Identities = 80/265 (30%), Positives = 119/265 (44%), Gaps = 60/265 (22%)
Query: 42 GFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVDVYNGHANGQ 101
G I S G+P YP +S+ TW ITVP+G + L F +LES LC YD+V V Q
Sbjct: 29 GQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV---ETEDQ 85
Query: 102 RIGRFCG------TFRPG--ALVSSGNKMMVQMISDANTAG--NGFMAMFSAA---EPNE 148
+ FCG PG ++S G+ M + SD + GF A + A E E
Sbjct: 86 VLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDECKE 145
Query: 149 RGDQ----------YCGG-------------------------LLDRPSGSFKTPNWPDR 173
R D+ Y GG L + +G +P++P+
Sbjct: 146 REDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVITSPDFPN- 204
Query: 174 DYPAGVTCVWHIVAPKNQLIELKFEK-FDVE--RDNYCRYDYVAVFNGGEVNDARRIGKY 230
YP C++ I + ++ L+FE FD+E + C YDY+ + G +V +G +
Sbjct: 205 PYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVGPKV-----LGPF 259
Query: 231 CGDSPPAPIVSERNELLIQFLSDLS 255
CG+ P PI ++ + +LI F SD S
Sbjct: 260 CGEKAPEPISTQSHSVLILFHSDNS 284
Score = 51.6 bits (122), Expect = 1e-06
Identities = 33/112 (29%), Positives = 56/112 (50%), Gaps = 6/112 (5%)
Query: 36 ILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFI-DLES--DNLCRYDFVD 92
+ T +G I S FP YP +S+C + I + EG +V L F I D+E + C YD++
Sbjct: 189 LFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIK 248
Query: 93 VYNGHANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAA 144
+ G + +G FCG P + + + +++ SD + G+ + AA
Sbjct: 249 IKVG---PKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAA 297
Score = 49.3 bits (116), Expect = 6e-06
Identities = 36/119 (30%), Positives = 54/119 (45%), Gaps = 16/119 (13%)
Query: 158 LDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVAVFN 217
L+ G ++P +PD YP+ W+I P I+L F F++E C YDYV V
Sbjct: 24 LNNMFGQIQSPGYPD-SYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVET 82
Query: 218 GGEVNDARRIGKYCG----DSPPAP----IVSERNELLIQFLSDLSLTA--DGFIGHYI 266
+V + +CG D+ P ++S + + I F SD S GF HY+
Sbjct: 83 EDQV-----LATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYM 136
>gi|21264359 mannan-binding lectin serine protease 1 isoform 2
precursor [Homo sapiens]
Length = 728
Score = 92.4 bits (228), Expect = 7e-19
Identities = 80/265 (30%), Positives = 119/265 (44%), Gaps = 60/265 (22%)
Query: 42 GFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVDVYNGHANGQ 101
G I S G+P YP +S+ TW ITVP+G + L F +LES LC YD+V V Q
Sbjct: 29 GQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV---ETEDQ 85
Query: 102 RIGRFCG------TFRPG--ALVSSGNKMMVQMISDANTAG--NGFMAMFSAA---EPNE 148
+ FCG PG ++S G+ M + SD + GF A + A E E
Sbjct: 86 VLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDECKE 145
Query: 149 RGDQ----------YCGG-------------------------LLDRPSGSFKTPNWPDR 173
R D+ Y GG L + +G +P++P+
Sbjct: 146 REDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVITSPDFPN- 204
Query: 174 DYPAGVTCVWHIVAPKNQLIELKFEK-FDVE--RDNYCRYDYVAVFNGGEVNDARRIGKY 230
YP C++ I + ++ L+FE FD+E + C YDY+ + G +V +G +
Sbjct: 205 PYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVGPKV-----LGPF 259
Query: 231 CGDSPPAPIVSERNELLIQFLSDLS 255
CG+ P PI ++ + +LI F SD S
Sbjct: 260 CGEKAPEPISTQSHSVLILFHSDNS 284
Score = 51.6 bits (122), Expect = 1e-06
Identities = 33/112 (29%), Positives = 56/112 (50%), Gaps = 6/112 (5%)
Query: 36 ILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFI-DLES--DNLCRYDFVD 92
+ T +G I S FP YP +S+C + I + EG +V L F I D+E + C YD++
Sbjct: 189 LFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIK 248
Query: 93 VYNGHANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAA 144
+ G + +G FCG P + + + +++ SD + G+ + AA
Sbjct: 249 IKVG---PKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAA 297
Score = 49.3 bits (116), Expect = 6e-06
Identities = 36/119 (30%), Positives = 54/119 (45%), Gaps = 16/119 (13%)
Query: 158 LDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVAVFN 217
L+ G ++P +PD YP+ W+I P I+L F F++E C YDYV V
Sbjct: 24 LNNMFGQIQSPGYPD-SYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVET 82
Query: 218 GGEVNDARRIGKYCG----DSPPAP----IVSERNELLIQFLSDLSLTA--DGFIGHYI 266
+V + +CG D+ P ++S + + I F SD S GF HY+
Sbjct: 83 EDQV-----LATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYM 136
>gi|21264357 mannan-binding lectin serine protease 1 isoform 1
precursor [Homo sapiens]
Length = 699
Score = 92.4 bits (228), Expect = 7e-19
Identities = 80/265 (30%), Positives = 119/265 (44%), Gaps = 60/265 (22%)
Query: 42 GFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVDVYNGHANGQ 101
G I S G+P YP +S+ TW ITVP+G + L F +LES LC YD+V V Q
Sbjct: 29 GQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV---ETEDQ 85
Query: 102 RIGRFCG------TFRPG--ALVSSGNKMMVQMISDANTAG--NGFMAMFSAA---EPNE 148
+ FCG PG ++S G+ M + SD + GF A + A E E
Sbjct: 86 VLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDECKE 145
Query: 149 RGDQ----------YCGG-------------------------LLDRPSGSFKTPNWPDR 173
R D+ Y GG L + +G +P++P+
Sbjct: 146 REDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVITSPDFPN- 204
Query: 174 DYPAGVTCVWHIVAPKNQLIELKFEK-FDVE--RDNYCRYDYVAVFNGGEVNDARRIGKY 230
YP C++ I + ++ L+FE FD+E + C YDY+ + G +V +G +
Sbjct: 205 PYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVGPKV-----LGPF 259
Query: 231 CGDSPPAPIVSERNELLIQFLSDLS 255
CG+ P PI ++ + +LI F SD S
Sbjct: 260 CGEKAPEPISTQSHSVLILFHSDNS 284
Score = 51.6 bits (122), Expect = 1e-06
Identities = 33/112 (29%), Positives = 56/112 (50%), Gaps = 6/112 (5%)
Query: 36 ILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFI-DLES--DNLCRYDFVD 92
+ T +G I S FP YP +S+C + I + EG +V L F I D+E + C YD++
Sbjct: 189 LFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIK 248
Query: 93 VYNGHANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAA 144
+ G + +G FCG P + + + +++ SD + G+ + AA
Sbjct: 249 IKVG---PKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAA 297
Score = 49.3 bits (116), Expect = 6e-06
Identities = 36/119 (30%), Positives = 54/119 (45%), Gaps = 16/119 (13%)
Query: 158 LDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVAVFN 217
L+ G ++P +PD YP+ W+I P I+L F F++E C YDYV V
Sbjct: 24 LNNMFGQIQSPGYPD-SYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVET 82
Query: 218 GGEVNDARRIGKYCG----DSPPAP----IVSERNELLIQFLSDLSLTA--DGFIGHYI 266
+V + +CG D+ P ++S + + I F SD S GF HY+
Sbjct: 83 EDQV-----LATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYM 136
>gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens]
Length = 3487
Score = 90.9 bits (224), Expect = 2e-18
Identities = 74/287 (25%), Positives = 117/287 (40%), Gaps = 65/287 (22%)
Query: 30 VFTCGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYD 89
V CGG LT G I S GFP Y + C WKI VPEG + + E + +D
Sbjct: 1793 VVPCGGNLTERRGTILSPGFPEPYLNSLNCVWKIVVPEGAGIQIQVVSFVTEQN----WD 1848
Query: 90 FVDVYNGHANG-QRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGF------MAMFS 142
++V++G N +G F GT P L S+ N++ + SD + + GF + + S
Sbjct: 1849 SLEVFDGADNTVTMLGSFSGTTVPALLNSTSNQLYLHFYSDISVSAAGFHLEYKTVGLSS 1908
Query: 143 AAEPN------ERGDQY------------------------------------------C 154
EP + G++Y C
Sbjct: 1909 CPEPAVPSNGVKTGERYLVNDVVSFQCEPGYALQGHAHISCMPGTVRRWNYPPPLCIAQC 1968
Query: 155 GGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVA 214
GG ++ G +P +P +YP+ + C W I P ++F F E + +DY+
Sbjct: 1969 GGTVEEMEGVILSPGFPG-NYPSNMDCSWKIALPVGFGAHIQFLNFSTEPN----HDYIE 2023
Query: 215 VFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGF 261
+ N G +R +G++ G P+ ++S +E + F SD S GF
Sbjct: 2024 IRN-GPYETSRMMGRFSGSELPSSLLSTSHETTVYFHSDHSQNRPGF 2069
Score = 89.4 bits (220), Expect = 6e-18
Identities = 79/299 (26%), Positives = 121/299 (40%), Gaps = 67/299 (22%)
Query: 30 VFTCGGILTGE-SGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRY 88
V CGG + GE SG + S G+P Y N C W I G + L+F D E +
Sbjct: 1268 VAECGGTVRGEVSGQVLSPGYPAPYEHNLNCIWTIEAEAGCTIGLHFLVFDTEEV----H 1323
Query: 89 DFVDVYNGHA-NGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMF------ 141
D + +++G +G + G P L S+ N +++Q +D T+ GF F
Sbjct: 1324 DVLRIWDGPVESGVLLKELSGPALPKDLHSTFNSVVLQFSTDFFTSKQGFAIQFSVSTAT 1383
Query: 142 SAAEPN------------ERGDQY------------------------------------ 153
S +P E GD
Sbjct: 1384 SCNDPGIPQNGSRSGDSWEAGDSTVFQCDPGYALQGSAEISCVKIENRFFWQPSPPTCIA 1443
Query: 154 -CGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDY 212
CGG L PSG +PN+P+ YP G C W + + +I L F F++E YD+
Sbjct: 1444 PCGGDLTGPSGVILSPNYPE-PYPPGKECDWKVTVSPDYVIALVFNIFNLEPG----YDF 1498
Query: 213 VAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIGHYIFRPKK 271
+ +++G + + + IG + G P I S N L + F SD S++ GF+ Y P++
Sbjct: 1499 LHIYDGRD-SLSPLIGSFYGSQLPGRIESSSNSLFLAFRSDASVSNAGFVIDYTENPRE 1556
Score = 84.3 bits (207), Expect = 2e-16
Identities = 46/117 (39%), Positives = 63/117 (53%), Gaps = 5/117 (4%)
Query: 23 QQSPERPVFTCGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLES 82
Q SP + CGG LTG SG I S +P YPP +C WK+TV V+ L F +LE
Sbjct: 1435 QPSPPTCIAPCGGDLTGPSGVILSPNYPEPYPPGKECDWKVTVSPDYVIALVFNIFNLEP 1494
Query: 83 DNLCRYDFVDVYNGHAN-GQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFM 138
YDF+ +Y+G + IG F G+ PG + SS N + + SDA+ + GF+
Sbjct: 1495 G----YDFLHIYDGRDSLSPLIGSFYGSQLPGRIESSSNSLFLAFRSDASVSNAGFV 1547
Score = 72.0 bits (175), Expect = 9e-13
Identities = 74/320 (23%), Positives = 115/320 (35%), Gaps = 78/320 (24%)
Query: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVD 92
CGG LT SG I S G+PG Y C W I G + + F E YD ++
Sbjct: 752 CGGHLTSPSGTILSPGWPGFYKDALSCAWVIEAQPGYPIKITFDRFKTE----VNYDTLE 807
Query: 93 VYNGHA-NGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSA-------- 143
V +G + IG + GT P L+S+ N + + +D + + GF +
Sbjct: 808 VRDGRTYSAPLIGVYHGTQVPQFLISTSNYLYLLFSTDKSHSDIGFQLRYETITLQSDHC 867
Query: 144 ---------------------------------------AEPNERG-------DQYCGGL 157
EPN + + CGG
Sbjct: 868 LDPGIPVNGQRHGNDFYVGALVTFSCDSGYTLSDGEPLECEPNFQWSRALPSCEALCGGF 927
Query: 158 LDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVAVFN 217
+ SG+ +P +PD YP + C W I + + F F +E +DY+ +
Sbjct: 928 IQGSSGTILSPGFPD-FYPNNLNCTWIIETSHGKGVFFTFHTFHLESG----HDYLLITE 982
Query: 218 GGEVNDARRIGKYCGDSPPAPI---VSERNELLIQFLSDLSLTADGF---IGHYIFRPKK 271
G R + G PAPI + ++F+SD S++ +GF Y P
Sbjct: 983 NGSFTQPLR--QLTGSRLPAPISAGLYGNFTAQVRFISDFSMSYEGFNITFSEYDLEP-- 1038
Query: 272 LPTTTEQPVTTTFPVTTGLK 291
E+P + + GL+
Sbjct: 1039 ----CEEPEVPAYSIRKGLQ 1054
Score = 67.4 bits (163), Expect = 2e-11
Identities = 72/291 (24%), Positives = 112/291 (38%), Gaps = 69/291 (23%)
Query: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVD 92
CGG + G SG I S GFP YP N CTW I GK V F LES +D++
Sbjct: 924 CGGFIQGSSGTILSPGFPDFYPNNLNCTWIIETSHGKGVFFTFHTFHLESG----HDYLL 979
Query: 93 VYNGHANGQRIGRFCGTFRPGALVSS--GN-KMMVQMISDANTAGNGFMAMFSA--AEPN 147
+ + Q + + G+ P + + GN V+ ISD + + GF FS EP
Sbjct: 980 ITENGSFTQPLRQLTGSRLPAPISAGLYGNFTAQVRFISDFSMSYEGFNITFSEYDLEPC 1039
Query: 148 E----------RGDQY------------------------------------------CG 155
E +G Q+ CG
Sbjct: 1040 EEPEVPAYSIRKGLQFGVGDTLTFSCFPGYRLEGTARITCLGGRRRLWSSPLPRCVAECG 1099
Query: 156 GLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVAV 215
+ G+ +PN+P +Y C++ I + I+LK F++ D + V
Sbjct: 1100 NSVTGTQGTLLSPNFP-VNYNNNHECIYSIQTQPGKGIQLKARAFELSEG-----DVLKV 1153
Query: 216 FNGGEVNDARRIGKYC-GDSPPAPIVSERNELLIQFLSDLSLTADGFIGHY 265
++G N AR +G + + + S + L + F++D T+ GF H+
Sbjct: 1154 YDGNN-NSARLLGVFSHSEMMGVTLNSTSSSLWLDFITDAENTSKGFELHF 1203
Score = 67.0 bits (162), Expect = 3e-11
Identities = 73/288 (25%), Positives = 106/288 (36%), Gaps = 65/288 (22%)
Query: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLES--DNLCRYD- 89
C L G +G + S GFP YP + CTW IT E + L F+ LE D L +D
Sbjct: 26 CTFQLHGPNGTVESPGFPYGYPNYANCTWTITAEEQHRIQLVFQSFALEEDFDVLSVFDG 85
Query: 90 -----------------------------------FVDVYNGHANGQRI--------GRF 106
V HA + + GR
Sbjct: 86 PPQPENLRTRLTGFQLPATIVSAATTLSLRLISDYAVSAQGFHATYEVLPSHTCGNPGRL 145
Query: 107 CGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAE---------PNERGDQYCGGL 157
+ G+ + G+K+ G+ + + +E P+ R D CGG
Sbjct: 146 PNGIQQGSTFNLGDKVRYSCNLGFFLEGHAVLTCHAGSENSATWDFPLPSCRADDACGGT 205
Query: 158 LDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVAVFN 217
L SG +P++P +Y C W I+A I L F F +E YD++ V
Sbjct: 206 LRGQSGIISSPHFPS-EYHNNADCTWTILAELGDTIALVFIDFQLEDG----YDFLEV-T 259
Query: 218 GGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIGHY 265
G E + + G S PAP++S +N L + F SD + GF Y
Sbjct: 260 GTEGSSL----WFTGASLPAPVISSKNWLRLHFTSDGNHRQRGFSAQY 303
Score = 67.0 bits (162), Expect = 3e-11
Identities = 80/308 (25%), Positives = 114/308 (37%), Gaps = 68/308 (22%)
Query: 25 SPERPVFT---CGGILTGESGFIGSEGFPGVYPPNSKCTWKIT-VPEGKVVVLNFRFIDL 80
S RPV C L G SG I S FP Y N+ C W IT + KV+ L F DL
Sbjct: 394 SDHRPVCRARMCDAHLRGPSGIITSPNFPIQYDNNAHCVWIITALNPSKVIKLAFEEFDL 453
Query: 81 ESDNLCRYDFVDVYNGHANGQR---IGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGF 137
E YD + V +G +G + + GT P +VS+ ++M + +D + + GF
Sbjct: 454 ERG----YDTLTVGDGGQDGDQKTVLYILTGTSVPDLIVSTNHQMWLLFQTDGSGSSLGF 509
Query: 138 MAMFSAAEPNERGDQYCGGLLDRPSGSF-------------------------KTPNWPD 172
A + E GD R F K W
Sbjct: 510 KASYEEIEQGSCGDPGIPAYGRREGSRFHHGDTLKFECQPAFELVGQKAITCQKNNQWSA 569
Query: 173 R------------DYPAGVT--------------CVWHIVAPKNQLIELKFEKFDVERDN 206
+ P+GV CVW I+A I L F DVE
Sbjct: 570 KKPGCVFSCFFNFTSPSGVVLSPNYPEDYGNHLHCVWLILARPESRIHLAFNDIDVEP-- 627
Query: 207 YCRYDYVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGF-IGHY 265
++D++ V G +A +G + G+ P+ I S + ++F +D S GF I
Sbjct: 628 --QFDFL-VIKDGATAEAPVLGTFSGNQLPSSITSSGHVARLEFQTDHSTGKRGFNITFT 684
Query: 266 IFRPKKLP 273
FR + P
Sbjct: 685 TFRHNECP 692
Score = 65.5 bits (158), Expect = 9e-11
Identities = 37/113 (32%), Positives = 58/113 (51%), Gaps = 5/113 (4%)
Query: 26 PERPVFTCGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNL 85
P + CGG + G I S GFPG YP N C+WKI +P G + F E +
Sbjct: 1961 PPLCIAQCGGTVEEMEGVILSPGFPGNYPSNMDCSWKIALPVGFGAHIQFLNFSTEPN-- 2018
Query: 86 CRYDFVDVYNG-HANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGF 137
+D++++ NG + + +GRF G+ P +L+S+ ++ V SD + GF
Sbjct: 2019 --HDYIEIRNGPYETSRMMGRFSGSELPSSLLSTSHETTVYFHSDHSQNRPGF 2069
Score = 65.1 bits (157), Expect = 1e-10
Identities = 43/136 (31%), Positives = 71/136 (52%), Gaps = 9/136 (6%)
Query: 154 CGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYV 213
CGG L G+ +P +P+ Y + CVW IV P+ I+++ F E++ +D +
Sbjct: 1796 CGGNLTERRGTILSPGFPE-PYLNSLNCVWKIVVPEGAGIQIQVVSFVTEQN----WDSL 1850
Query: 214 AVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIGHYIFRPKKLP 273
VF+G + N +G + G + PA + S N+L + F SD+S++A GF H ++ L
Sbjct: 1851 EVFDGAD-NTVTMLGSFSGTTVPALLNSTSNQLYLHFYSDISVSAAGF--HLEYKTVGLS 1907
Query: 274 TTTEQPVTTTFPVTTG 289
+ E P + V TG
Sbjct: 1908 SCPE-PAVPSNGVKTG 1922
Score = 64.3 bits (155), Expect = 2e-10
Identities = 75/306 (24%), Positives = 112/306 (36%), Gaps = 69/306 (22%)
Query: 15 AAATQLSRQQSPERP--VFTCGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVV 72
A Q + Q S ++P VF+C T SG + S +P Y + C W I +
Sbjct: 558 AITCQKNNQWSAKKPGCVFSCFFNFTSPSGVVLSPNYPEDYGNHLHCVWLILARPESRIH 617
Query: 73 LNFRFIDLESDNLCRYDFVDVYNGH-ANGQRIGRFCG----------------------- 108
L F ID+E ++DF+ + +G A +G F G
Sbjct: 618 LAFNDIDVEP----QFDFLVIKDGATAEAPVLGTFSGNQLPSSITSSGHVARLEFQTDHS 673
Query: 109 -----------TFRPGALVSSGNKMMVQMISDANTAGNGFMAM----FSAAEPNE----- 148
TFR G + + D+ G+ + F + +E
Sbjct: 674 TGKRGFNITFTTFRHNECPDPGVPVNGKRFGDSLQLGSSISFLCDEGFLGTQGSETITCV 733
Query: 149 -------------RGDQYCGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIEL 195
R + CGG L PSG+ +P WP Y ++C W I A I++
Sbjct: 734 LKEGSVVWNSAVLRCEAPCGGHLTSPSGTILSPGWPG-FYKDALSCAWVIEAQPGYPIKI 792
Query: 196 KFEKFDVERDNYCRYDYVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLS 255
F++F E YD + V G A IG Y G P ++S N L + F +D S
Sbjct: 793 TFDRFKTE----VNYDTLEV-RDGRTYSAPLIGVYHGTQVPQFLISTSNYLYLLFSTDKS 847
Query: 256 LTADGF 261
+ GF
Sbjct: 848 HSDIGF 853
Score = 63.2 bits (152), Expect = 4e-10
Identities = 39/116 (33%), Positives = 51/116 (43%), Gaps = 7/116 (6%)
Query: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVD 92
CGG L G+SG I S FP Y N+ CTW I G + L F LE YDF++
Sbjct: 202 CGGTLRGQSGIISSPHFPSEYHNNADCTWTILAELGDTIALVFIDFQLEDG----YDFLE 257
Query: 93 VYNGHANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNE 148
V + F G P ++SS N + + SD N GF A + + E
Sbjct: 258 VTGTEGSSL---WFTGASLPAPVISSKNWLRLHFTSDGNHRQRGFSAQYQVKKQIE 310
Score = 62.4 bits (150), Expect = 7e-10
Identities = 38/112 (33%), Positives = 55/112 (49%), Gaps = 6/112 (5%)
Query: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVD 92
CGG +T +G + S GFP Y + C W ITVP G V LN + E DF+
Sbjct: 2182 CGGNITSSNGTVYSPGFPSPYSSSQDCVWLITVPIGHGVRLNLSLLQTEPSG----DFIT 2237
Query: 93 VYNG-HANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSA 143
+++G R+G F + + SS N+++++ DA T G F FSA
Sbjct: 2238 IWDGPQQTAPRLGVFTRSMAKKTVQSSSNQVLLKFHRDAATGGI-FAIAFSA 2288
Score = 58.5 bits (140), Expect = 1e-08
Identities = 42/137 (30%), Positives = 65/137 (47%), Gaps = 13/137 (9%)
Query: 152 QYCGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYD 211
Q C L P+G+ ++P +P YP C W I A + I+L F+ F +E D +D
Sbjct: 24 QNCTFQLHGPNGTVESPGFP-YGYPNYANCTWTITAEEQHRIQLVFQSFALEED----FD 78
Query: 212 YVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGF-------IGH 264
++VF+G + R + G PA IVS L ++ +SD +++A GF H
Sbjct: 79 VLSVFDGPPQPENLRT-RLTGFQLPATIVSAATTLSLRLISDYAVSAQGFHATYEVLPSH 137
Query: 265 YIFRPKKLPTTTEQPVT 281
P +LP +Q T
Sbjct: 138 TCGNPGRLPNGIQQGST 154
Score = 52.4 bits (124), Expect = 8e-07
Identities = 38/120 (31%), Positives = 55/120 (45%), Gaps = 7/120 (5%)
Query: 28 RPVFTCGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCR 87
R V CG +TG G + S FP Y N +C + I GK + L R +L
Sbjct: 1093 RCVAECGNSVTGTQGTLLSPNFPVNYNNNHECIYSIQTQPGKGIQLKARAFELSEG---- 1148
Query: 88 YDFVDVYNGHANGQR-IGRFCGTFRPG-ALVSSGNKMMVQMISDANTAGNGFMAMFSAAE 145
D + VY+G+ N R +G F + G L S+ + + + I+DA GF FS+ E
Sbjct: 1149 -DVLKVYDGNNNSARLLGVFSHSEMMGVTLNSTSSSLWLDFITDAENTSKGFELHFSSFE 1207
Score = 45.8 bits (107), Expect = 7e-05
Identities = 33/123 (26%), Positives = 55/123 (44%), Gaps = 15/123 (12%)
Query: 28 RPVFT--CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNL 85
RPV T CGG G G + S +P Y C + +TVP+ VV F F +
Sbjct: 1612 RPVCTAPCGGQYVGSDGVVLSPNYPQNYTSGQICLYFVTVPKDYVVFGQFAFF-----HT 1666
Query: 86 CRYDFVDVYNGHANGQRI-----GRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAM 140
D V+V++GH+ R+ G G P +++ N+++++ + GF +
Sbjct: 1667 ALNDVVEVHDGHSQHSRLLSSLSGSHTGESLP---LATSNQVLIKFSAKGLAPARGFHFV 1723
Query: 141 FSA 143
+ A
Sbjct: 1724 YQA 1726
Score = 40.4 bits (93), Expect = 0.003
Identities = 30/111 (27%), Positives = 51/111 (45%), Gaps = 8/111 (7%)
Query: 36 ILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVDVYN 95
+LT +G I S+ +PG YP C+W + V + L + E +YD ++++
Sbjct: 2360 LLTDSTGVILSQSYPGSYPQFQTCSWLVRVEPDYNISLTVEYFLSEK----QYDEFEIFD 2415
Query: 96 GHANGQR--IGRFCGTF-RPGALVSSGNKMMVQMISDANTAGNGFMAMFSA 143
G +GQ + G + P + SS N + ++ SD GF +SA
Sbjct: 2416 G-PSGQSPLLKALSGNYSAPLIVTSSSNSVYLRWSSDHAYNRKGFKIRYSA 2465
Score = 38.9 bits (89), Expect = 0.009
Identities = 31/127 (24%), Positives = 61/127 (48%), Gaps = 14/127 (11%)
Query: 154 CGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYV 213
CGG G +PN+P ++Y +G C++ + PK+ ++ +F F + D V
Sbjct: 1619 CGGQYVGSDGVVLSPNYP-QNYTSGQICLYFVTVPKDYVVFGQFAFFHTALN-----DVV 1672
Query: 214 AVFNGGEVND---ARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIGHYIFRPK 270
V +G + + G + G+S P ++ N++LI+F + A GF H++++
Sbjct: 1673 EVHDGHSQHSRLLSSLSGSHTGESLP---LATSNQVLIKFSAKGLAPARGF--HFVYQAV 1727
Query: 271 KLPTTTE 277
+ T+
Sbjct: 1728 PRTSATQ 1734
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.138 0.430
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,745,591
Number of Sequences: 37866
Number of extensions: 774068
Number of successful extensions: 2866
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 86
Number of HSP's successfully gapped in prelim test: 13
Number of HSP's that attempted gapping in prelim test: 1963
Number of HSP's gapped (non-prelim): 418
length of query: 415
length of database: 18,247,518
effective HSP length: 105
effective length of query: 310
effective length of database: 14,271,588
effective search space: 4424192280
effective search space used: 4424192280
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.